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Search of human proteins with 171906559
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|171906559 peripheral benzodiazepine receptor-associated
protein 1 isoform a [Homo sapiens]
(1857 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|171906559 peripheral benzodiazepine receptor-associated prote... 3755 0.0
gi|171906567 peripheral benzodiazepine receptor-associated prote... 3591 0.0
gi|140561070 RIM-binding protein 2 [Homo sapiens] 425 e-118
gi|191252814 RIMS binding protein 3B [Homo sapiens] 370 e-102
gi|191252806 RIMS binding protein 3C [Homo sapiens] 369 e-101
gi|153792195 DKFZP434H0735 protein [Homo sapiens] 369 e-101
gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo sapi... 81 8e-15
gi|148746195 trichohyalin [Homo sapiens] 81 8e-15
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 80 2e-14
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 75 6e-13
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 75 6e-13
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 75 6e-13
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 75 6e-13
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 75 6e-13
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 75 6e-13
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 75 6e-13
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 75 6e-13
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 73 2e-12
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 73 3e-12
gi|58530840 desmoplakin isoform I [Homo sapiens] 72 4e-12
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 71 9e-12
gi|157042792 coiled-coil domain containing 64B [Homo sapiens] 71 1e-11
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 70 2e-11
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 69 3e-11
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 69 3e-11
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 69 3e-11
gi|221139761 zinc finger protein 853 [Homo sapiens] 69 4e-11
gi|154354987 hook homolog 2 isoform 2 [Homo sapiens] 69 4e-11
gi|21735548 centrosomal protein 2 [Homo sapiens] 69 6e-11
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 69 6e-11
>gi|171906559 peripheral benzodiazepine receptor-associated protein 1
isoform a [Homo sapiens]
Length = 1857
Score = 3755 bits (9738), Expect = 0.0
Identities = 1857/1857 (100%), Positives = 1857/1857 (100%)
Query: 1 MEQLTTLPRPGDPGAMEPWALPTWHSWTPGRGGEPSSAAPSIADTPPAALQLQELRSEES 60
MEQLTTLPRPGDPGAMEPWALPTWHSWTPGRGGEPSSAAPSIADTPPAALQLQELRSEES
Sbjct: 1 MEQLTTLPRPGDPGAMEPWALPTWHSWTPGRGGEPSSAAPSIADTPPAALQLQELRSEES 60
Query: 61 SKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGD 120
SKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGD
Sbjct: 61 SKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGD 120
Query: 121 RPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERA 180
RPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERA
Sbjct: 121 RPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERA 180
Query: 181 RKLQETNLRVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRE 240
RKLQETNLRVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRE
Sbjct: 181 RKLQETNLRVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRE 240
Query: 241 LQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPAL 300
LQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPAL
Sbjct: 241 LQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPAL 300
Query: 301 QARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARK 360
QARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARK
Sbjct: 301 QARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARK 360
Query: 361 KQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSA 420
KQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSA
Sbjct: 361 KQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSA 420
Query: 421 LRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ 480
LRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ
Sbjct: 421 LRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ 480
Query: 481 REHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALD 540
REHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALD
Sbjct: 481 REHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALD 540
Query: 541 CGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKK 600
CGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKK
Sbjct: 541 CGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKK 600
Query: 601 AESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAAPEGSRGGARIQVFLA 660
AESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAAPEGSRGGARIQVFLA
Sbjct: 601 AESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAAPEGSRGGARIQVFLA 660
Query: 661 RYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSD 720
RYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSD
Sbjct: 661 RYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSD 720
Query: 721 DDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDELSLSP 780
DDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDELSLSP
Sbjct: 721 DDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDELSLSP 780
Query: 781 SPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVNGELRQALGPGAP 840
SPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVNGELRQALGPGAP
Sbjct: 781 SPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVNGELRQALGPGAP 840
Query: 841 PKAVLENLDLWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEI 900
PKAVLENLDLWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEI
Sbjct: 841 PKAVLENLDLWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEI 900
Query: 901 TWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWE 960
TWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWE
Sbjct: 901 TWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWE 960
Query: 961 RLEQRAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYA 1020
RLEQRAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYA
Sbjct: 961 RLEQRAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYA 1020
Query: 1021 IYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAP 1080
IYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAP
Sbjct: 1021 IYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAP 1080
Query: 1081 ASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMA 1140
ASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMA
Sbjct: 1081 ASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMA 1140
Query: 1141 KGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACP 1200
KGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACP
Sbjct: 1141 KGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACP 1200
Query: 1201 ASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDI 1260
ASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDI
Sbjct: 1201 ASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDI 1260
Query: 1261 QEEEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELP 1320
QEEEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELP
Sbjct: 1261 QEEEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELP 1320
Query: 1321 LQQFCSKKLFSIPEEEEEEEEDEEEEKSGAGCSSRDPGPPEPALLGLGCDSGQPRRPGQC 1380
LQQFCSKKLFSIPEEEEEEEEDEEEEKSGAGCSSRDPGPPEPALLGLGCDSGQPRRPGQC
Sbjct: 1321 LQQFCSKKLFSIPEEEEEEEEDEEEEKSGAGCSSRDPGPPEPALLGLGCDSGQPRRPGQC 1380
Query: 1381 PLSPESSRAGDCLEDMPGLVGGSSRRRGGGSPEKPPSRRRPPDPREHCSRLLSNNGPQAS 1440
PLSPESSRAGDCLEDMPGLVGGSSRRRGGGSPEKPPSRRRPPDPREHCSRLLSNNGPQAS
Sbjct: 1381 PLSPESSRAGDCLEDMPGLVGGSSRRRGGGSPEKPPSRRRPPDPREHCSRLLSNNGPQAS 1440
Query: 1441 GRLGPTRERGGLPVIEGPRTGLEASGRGRLGPSRRCSRGRALEPGLASCLSPKCLEISIE 1500
GRLGPTRERGGLPVIEGPRTGLEASGRGRLGPSRRCSRGRALEPGLASCLSPKCLEISIE
Sbjct: 1441 GRLGPTRERGGLPVIEGPRTGLEASGRGRLGPSRRCSRGRALEPGLASCLSPKCLEISIE 1500
Query: 1501 YDSEDEQEAGSGGISITSSCYPGDGEAWGTATVGRPRGPPKANSGPKPYPRLPAWEKGEP 1560
YDSEDEQEAGSGGISITSSCYPGDGEAWGTATVGRPRGPPKANSGPKPYPRLPAWEKGEP
Sbjct: 1501 YDSEDEQEAGSGGISITSSCYPGDGEAWGTATVGRPRGPPKANSGPKPYPRLPAWEKGEP 1560
Query: 1561 ERRGRSATGRAKEPLSRATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETL 1620
ERRGRSATGRAKEPLSRATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETL
Sbjct: 1561 ERRGRSATGRAKEPLSRATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETL 1620
Query: 1621 AYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRT 1680
AYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRT
Sbjct: 1621 AYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRT 1680
Query: 1681 GYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSK 1740
GYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSK
Sbjct: 1681 GYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSK 1740
Query: 1741 KAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITV 1800
KAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITV
Sbjct: 1741 KAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITV 1800
Query: 1801 FGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGLDREPRTPQAESQRTRRRRVQC 1857
FGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGLDREPRTPQAESQRTRRRRVQC
Sbjct: 1801 FGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGLDREPRTPQAESQRTRRRRVQC 1857
>gi|171906567 peripheral benzodiazepine receptor-associated protein 1
isoform b [Homo sapiens]
Length = 1797
Score = 3591 bits (9312), Expect = 0.0
Identities = 1788/1857 (96%), Positives = 1792/1857 (96%), Gaps = 60/1857 (3%)
Query: 1 MEQLTTLPRPGDPGAMEPWALPTWHSWTPGRGGEPSSAAPSIADTPPAALQLQELRSEES 60
MEQLTTLPRPGDPGAMEPWALPTWHSWTPGRGGEPSSAAPSIADTPPAALQLQELRSEES
Sbjct: 1 MEQLTTLPRPGDPGAMEPWALPTWHSWTPGRGGEPSSAAPSIADTPPAALQLQELRSEES 60
Query: 61 SKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGD 120
SKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGD
Sbjct: 61 SKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGD 120
Query: 121 RPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERA 180
RPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVI A
Sbjct: 121 RPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVI-------A 173
Query: 181 RKLQETNLRVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRE 240
++L+E RAR L ET +
Sbjct: 174 KRLEE---------------------------RARKLQETNLRV---------------- 190
Query: 241 LQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPAL 300
EGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPAL
Sbjct: 191 ----------EGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPAL 240
Query: 301 QARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARK 360
QARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARK
Sbjct: 241 QARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARK 300
Query: 361 KQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSA 420
KQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSA
Sbjct: 301 KQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSA 360
Query: 421 LRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ 480
LRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ
Sbjct: 361 LRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ 420
Query: 481 REHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALD 540
REHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALD
Sbjct: 421 REHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALD 480
Query: 541 CGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKK 600
CGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKK
Sbjct: 481 CGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKK 540
Query: 601 AESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAAPEGSRGGARIQVFLA 660
AESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAAPEGSRGGARIQVFLA
Sbjct: 541 AESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAAPEGSRGGARIQVFLA 600
Query: 661 RYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSD 720
RYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSD
Sbjct: 601 RYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSD 660
Query: 721 DDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDELSLSP 780
DDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDELSLSP
Sbjct: 661 DDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDELSLSP 720
Query: 781 SPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVNGELRQALGPGAP 840
SPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVNGELRQALGPGAP
Sbjct: 721 SPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVNGELRQALGPGAP 780
Query: 841 PKAVLENLDLWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEI 900
PKAVLENLDLWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEI
Sbjct: 781 PKAVLENLDLWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEI 840
Query: 901 TWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWE 960
TWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWE
Sbjct: 841 TWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWE 900
Query: 961 RLEQRAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYA 1020
RLEQRAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYA
Sbjct: 901 RLEQRAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYA 960
Query: 1021 IYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAP 1080
IYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAP
Sbjct: 961 IYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAP 1020
Query: 1081 ASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMA 1140
ASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMA
Sbjct: 1021 ASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMA 1080
Query: 1141 KGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACP 1200
KGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACP
Sbjct: 1081 KGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACP 1140
Query: 1201 ASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDI 1260
ASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDI
Sbjct: 1141 ASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDI 1200
Query: 1261 QEEEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELP 1320
QEEEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELP
Sbjct: 1201 QEEEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELP 1260
Query: 1321 LQQFCSKKLFSIPEEEEEEEEDEEEEKSGAGCSSRDPGPPEPALLGLGCDSGQPRRPGQC 1380
LQQFCSKKLFSIPEEEEEEEEDEEEEKSGAGCSSRDPGPPEPALLGLGCDSGQPRRPGQC
Sbjct: 1261 LQQFCSKKLFSIPEEEEEEEEDEEEEKSGAGCSSRDPGPPEPALLGLGCDSGQPRRPGQC 1320
Query: 1381 PLSPESSRAGDCLEDMPGLVGGSSRRRGGGSPEKPPSRRRPPDPREHCSRLLSNNGPQAS 1440
PLSPESSRAGDCLEDMPGLVGGSSRRRGGGSPEKPPSRRRPPDPREHCSRLLSNNGPQAS
Sbjct: 1321 PLSPESSRAGDCLEDMPGLVGGSSRRRGGGSPEKPPSRRRPPDPREHCSRLLSNNGPQAS 1380
Query: 1441 GRLGPTRERGGLPVIEGPRTGLEASGRGRLGPSRRCSRGRALEPGLASCLSPKCLEISIE 1500
GRLGPTRERGGLPVIEGPRTGLEASGRGRLGPSRRCSRGRALEPGLASCLSPKCLEISIE
Sbjct: 1381 GRLGPTRERGGLPVIEGPRTGLEASGRGRLGPSRRCSRGRALEPGLASCLSPKCLEISIE 1440
Query: 1501 YDSEDEQEAGSGGISITSSCYPGDGEAWGTATVGRPRGPPKANSGPKPYPRLPAWEKGEP 1560
YDSEDEQEAGSGGISITSSCYPGDGEAWGTATVGRPRGPPKANSGPKPYPRLPAWEKGEP
Sbjct: 1441 YDSEDEQEAGSGGISITSSCYPGDGEAWGTATVGRPRGPPKANSGPKPYPRLPAWEKGEP 1500
Query: 1561 ERRGRSATGRAKEPLSRATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETL 1620
ERRGRSATGRAKEPLSRATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETL
Sbjct: 1501 ERRGRSATGRAKEPLSRATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETL 1560
Query: 1621 AYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRT 1680
AYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRT
Sbjct: 1561 AYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRT 1620
Query: 1681 GYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSK 1740
GYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSK
Sbjct: 1621 GYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSK 1680
Query: 1741 KAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITV 1800
KAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITV
Sbjct: 1681 KAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITV 1740
Query: 1801 FGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGLDREPRTPQAESQRTRRRRVQC 1857
FGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGLDREPRTPQAESQRTRRRRVQC
Sbjct: 1741 FGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGLDREPRTPQAESQRTRRRRVQC 1797
>gi|140561070 RIM-binding protein 2 [Homo sapiens]
Length = 1052
Score = 425 bits (1093), Expect = e-118
Identities = 301/865 (34%), Positives = 438/865 (50%), Gaps = 116/865 (13%)
Query: 441 MREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQAR 500
MRE A+RRQQL++EH+QA L KQ+E+ LQ +++
Sbjct: 1 MREAAERRQQLQLEHDQALAVLSAKQQEIDLLQ------------------------KSK 36
Query: 501 VRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALDCGSLGDCPPPPCCCSIPQPC 560
VRELEE+CR+Q+EQF+LL+++L+ FR H G +DLL +
Sbjct: 37 VRELEEKCRTQSEQFNLLSRDLEKFRQHAGKIDLLGGS---------------------- 74
Query: 561 RGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKKAESL--SNSSHSESIHNSPK 618
P D+ P S+P P + G+ K ES +S+ E I P+
Sbjct: 75 -AVAPLDISTAP----------SKPFPQFMNGLATSLGKGQESAIGGSSAIGEYIRPLPQ 123
Query: 619 SCPTPEVDTA---------SEVEELEADSVSLLPAAPEGSRGGARIQVFLARYSYNPFEG 669
PE +A S E+D + + R ++ + +ARYSYNPF+G
Sbjct: 124 PGDRPEPLSAKPTFLSRSGSARCRSESDMENERNSNTSKQRYSGKVHLCVARYSYNPFDG 183
Query: 670 PNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSDDDLLTSLPP 729
PNENPEAELPLTAG+Y+Y+YG+MDEDGF+EGEL+DG+RGLVPSNFV+ V D++
Sbjct: 184 PNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQDNE------- 236
Query: 730 ELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDEL--SLSPSPEGLGE 787
+ L+ + G E + G G+ + P + D +L + + +GE
Sbjct: 237 --SRLASTLGNEQDQNFINHSGIGLEGEHILDLHSPTHIDAGITDNSAGTLDVNIDDIGE 294
Query: 788 PPAVPYPRRLVVLKQLAHSVVLAWEP---PPEQVELHGFHICVNGELRQALGPGAPPKAV 844
VPYPR++ ++KQLA SV++ WEP PP + +++ V+ E R L G+ KA+
Sbjct: 295 -DIVPYPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKAL 353
Query: 845 LENLDLWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEITWVP 904
+E L++ A ISVQ +TSRGSSD L+C L VG V PS LRV +T SA+++W+P
Sbjct: 354 IEKLNMAACTYRISVQCVTSRGSSDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSWLP 413
Query: 905 GNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWERLEQ 964
NSN +H I+LN EE + Y F +LRP Y+ +V A+ P Q PW+ E+ E+
Sbjct: 414 TNSNYSHVIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAK-PHQMPWQLPLEQREK 472
Query: 965 RAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYAIYAD 1024
+ A ++F+TLPAGPP P DV ++ G +P + +SW P + G SNG VTGY +YA
Sbjct: 473 KEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGYGVYAK 532
Query: 1025 GQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAPASLP 1084
GQ++ EV PTA S VEL +L+ L+ + V VRT+S GES DS A + P L
Sbjct: 533 GQRVAEVIFPTADSTAVELVRLRSLE-AKGVTVRTLSAQGESVDSAVAAVPPEL------ 585
Query: 1085 ARVSCPSPHPSPEARA-PLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMAKGS 1143
+ P+PHP P ++ PLAS+ G P + +H P + +P G
Sbjct: 586 --LVPPTPHPRPAPQSKPLASS----GVPETKDEHLGPHARMDEAWEQSRAPG--PVHGH 637
Query: 1144 HEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACPASS 1203
+PP + + + + T ++T+ + AA +A+ SS
Sbjct: 638 MLEPPVGPGRRSPSPSRILPQPQGTPVSTTVAKAMAREAAQRVAESSRLEKRSVFLERSS 697
Query: 1204 STQGARAQQAPNTEMCQGGDPGSGLRPRAEKED---TAELG-----VHLVNSLVDHGRNS 1255
+ Q A + + D R A +D +ELG H + R S
Sbjct: 698 AGQYAASDEE------DAYDSPDFKRRGASVDDFLKGSELGKQPHCCHGDEYHTESSRGS 751
Query: 1256 DLSDIQEEEEEE--EEEEEEELGSR 1278
DLSDI EE+EEE E + E+ G R
Sbjct: 752 DLSDIMEEDEEELYSEMQLEDGGRR 776
Score = 207 bits (526), Expect = 1e-52
Identities = 127/275 (46%), Positives = 157/275 (57%), Gaps = 47/275 (17%)
Query: 1565 RSATGRAKEPLSRATETGEARGQDGSGRRGPQ-KRGVRVLRPSTAELVP-----ARSP-- 1616
R +G + L A D GRR P+ G + RP T + SP
Sbjct: 776 RRPSGTSHNALKILGNPASAGRVDHMGRRFPRGSAGPQRSRPVTVPSIDDYGRDRLSPDF 835
Query: 1617 ---SET-LAYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFY 1672
SET + LP RIFVALFDYDP++MSPNPDA EEELPF+EGQI+KV+GDKDADGFY
Sbjct: 836 YEESETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFY 895
Query: 1673 QGEGGGRTGYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGP 1732
+GE R G IPCNMV+E+ D QLL++G+L + +E
Sbjct: 896 RGETCARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVE----------------K 939
Query: 1733 PPKPRRSKKAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPF 1792
+ RRS + S + MVA +DY+P+ESSPN+DVEAEL F
Sbjct: 940 IERSRRSGRRHS-------------------VSTRRMVALYDYDPRESSPNVDVEAELTF 980
Query: 1793 RAGDVITVFGGMDDDGFYYGELNGQRGLVPSNFLE 1827
GD+ITVFG +D+DGFYYGELNGQ+GLVPSNFLE
Sbjct: 981 CTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLE 1015
Score = 70.9 bits (172), Expect = 1e-11
Identities = 36/62 (58%), Positives = 45/62 (72%), Gaps = 2/62 (3%)
Query: 1767 HSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGE-LNGQRGLVPSNF 1825
H VA + YNP + PN + EAELP AG + V+G MD+DGFY GE L+GQRGLVPSNF
Sbjct: 170 HLCVARYSYNPFDG-PNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNF 228
Query: 1826 LE 1827
++
Sbjct: 229 VD 230
Score = 69.3 bits (168), Expect = 3e-11
Identities = 36/75 (48%), Positives = 49/75 (65%), Gaps = 2/75 (2%)
Query: 648 GSRGGARIQVFLARYSYNPFEG-PNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGR 706
G R + +A Y Y+P E PN + EAEL G+ I ++G +DEDGF+ GEL +G+
Sbjct: 947 GRRHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGEL-NGQ 1005
Query: 707 RGLVPSNFVERVSDD 721
+GLVPSNF+E V DD
Sbjct: 1006 KGLVPSNFLEEVPDD 1020
Score = 66.6 bits (161), Expect = 2e-10
Identities = 35/67 (52%), Positives = 41/67 (61%), Gaps = 1/67 (1%)
Query: 1628 RIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNM 1687
R VAL+DYDP SPN D E EL F G I+ VFG+ D DGFY GE G+ G +P N
Sbjct: 955 RRMVALYDYDPRESSPNVDV-EAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNF 1013
Query: 1688 VAEVAVD 1694
+ EV D
Sbjct: 1014 LEEVPDD 1020
Score = 54.3 bits (129), Expect = 1e-06
Identities = 28/69 (40%), Positives = 40/69 (57%), Gaps = 3/69 (4%)
Query: 656 QVFLARYSYNPFE-GPNENP-EAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSN 713
++F+A + Y+P PN + E ELP G+ I +YG+ D DGF+ GE R GL+P N
Sbjct: 851 RIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGETC-ARLGLIPCN 909
Query: 714 FVERVSDDD 722
V + DD
Sbjct: 910 MVSEIQADD 918
Score = 48.9 bits (115), Expect = 5e-05
Identities = 28/63 (44%), Positives = 37/63 (58%), Gaps = 3/63 (4%)
Query: 1627 VRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGE-GGGRTGYIPC 1685
V + VA + Y+P PN + E ELP G+ L V+GD D DGFY+GE G+ G +P
Sbjct: 169 VHLCVARYSYNPFD-GPNENP-EAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPS 226
Query: 1686 NMV 1688
N V
Sbjct: 227 NFV 229
>gi|191252814 RIMS binding protein 3B [Homo sapiens]
Length = 1639
Score = 370 bits (949), Expect = e-102
Identities = 368/1148 (32%), Positives = 519/1148 (45%), Gaps = 220/1148 (19%)
Query: 123 NLELLRALGELRQRCAILKEENQMLRKSSFP-ETEEKVRRLKRKNAELAVIAKRLEERAR 181
N L +AL L +RC L+EEN+ LR++ P + +EKV+RLK K AEL +A+RL +RAR
Sbjct: 377 NWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRAR 436
Query: 182 KLQETNLRVVSAPLPRPGTS-LELCRKALARQRARDLSETASALLAKDKQIAALQRECRE 240
+LQETNLR VSAP+P + LELC+ ARQRARDLSE ASA LAKDKQI L++EC
Sbjct: 437 ELQETNLRAVSAPIPGESCAGLELCQ-VFARQRARDLSEQASAPLAKDKQIEELRQECHL 495
Query: 241 LQARLTL-------VGKEGP--QWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLP 291
LQAR+ G+ GP QWL+VRD DRL RESQREVLRLQRQ+ L+
Sbjct: 496 LQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQ--------- 546
Query: 292 PSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKC 351
Q GA P A G++ E E +++ LE EL ++R++C
Sbjct: 547 ---------QGNGGA-WPEAGGQSATCE------------EVRRQMLALERELDQRRREC 584
Query: 352 ESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLL 411
+ L +A +RR EE E QL+ A +NA L EEN RL + +VE EN+E+RG L
Sbjct: 585 QELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLG 644
Query: 412 GVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRR 471
QERD++ GL + EQ+L+ R+QQL+ + ++A L +E++
Sbjct: 645 RACQERDAS-----GLIA-----EQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQA 694
Query: 472 LQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR---LH 528
LQ + Q+ ES + R + R + S +++Q R L
Sbjct: 695 LQCRPGHPPEQPWETSQMPESQVKGS----RRPKFHARPEDYAVSQPNRDIQEKREASLE 750
Query: 529 PGPLDLLTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPA 588
P+ L SA S+PQ SE PA
Sbjct: 751 ESPVALGESA----------------SVPQ-----------------------VSETVPA 771
Query: 589 TLTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSL-LPAAPE 647
+ + +KK S SNSS S+ + S PT + DTASEV++LE DSVSL L
Sbjct: 772 S-----QPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGS 826
Query: 648 GSRGGARIQVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRR 707
+ ++++F+A+Y+YNPFEGPN++PE ELPLTAG+YIYI+G+MDEDGF+EGEL DGRR
Sbjct: 827 AAPAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRR 886
Query: 708 GLVPSNFVERVSDDDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRP 767
GLVPSNFVE++ D + LP + DL G S + Q
Sbjct: 887 GLVPSNFVEQIPDSYIPGCLPAKSPDL---------------------GPSQLPAGQDEA 925
Query: 768 EEEDAGDELSLSPSPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICV 827
EED+ LS +G+ + R L + ++ +A E + E C
Sbjct: 926 LEEDS----LLSGKAQGMVD-------RGLCQMVRVGSKTEVATEILDTKTE-----ACQ 969
Query: 828 NGELRQALGPGAPPKAVLENLD-LWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPS 886
G L Q++G + +L L P+ + +Q +T+ +S + + VV
Sbjct: 970 LG-LLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTA--TSANITWVYSSHRHPHVVYL 1026
Query: 887 QLRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVE 946
R H LT G H P YW T + V
Sbjct: 1027 DDREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTM---------SSTVT 1077
Query: 947 AQLPPQGPWEPGWERLEQRAAT---LQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPV 1003
GP P E L +R A+ L + LP A G S G+ + +
Sbjct: 1078 FDTLLAGPPYPPLEVLVERHASPGVLVVSWLPVTIDSA--------GSSNGVQVTGY--- 1126
Query: 1004 TIDAAGTSNGVRVTGYAIYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPH 1063
A ++G++V A G ++ E SQLQ+ ++V VRTMS
Sbjct: 1127 ----AVYADGLKVCEVADATAGSTVL------------EFSQLQVPLTWQKVSVRTMSLC 1170
Query: 1064 GESADSIPAPITPALA-----PASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQH 1118
GES DS+PA I P + P +C GDPS+ +
Sbjct: 1171 GESLDSVPAQIPEDFFMCHRWPETPPFSYTC--------------------GDPST-YRV 1209
Query: 1119 PAPLGTQEPPGAPPASPSREMAKGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKD 1178
P+ Q+ APP++ + GS +P A + A R + S LG +
Sbjct: 1210 TFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLE-----AFFEEPPRRQSPVSNLGSEG 1264
Query: 1179 --PGPAAPSLAKQEAEWTAGEACPASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKED 1236
P A S A++ AE A E C Q + P + Q G+ + + +
Sbjct: 1265 ECPSSGAGSQAQELAE--AWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTSKS 1322
Query: 1237 TAELGVHL 1244
A +HL
Sbjct: 1323 PAPGFIHL 1330
Score = 127 bits (319), Expect = 1e-28
Identities = 97/265 (36%), Positives = 130/265 (49%), Gaps = 37/265 (13%)
Query: 1577 RATETGEARGQDGSGRRGPQ----KRGVRVLRPSTAELVPARS----------PSETLAY 1622
R TE E R + R Q KRG ++ PS+A L PA S P +
Sbjct: 1391 RGTERREERREPEPHSRQGQALGVKRGCQLHEPSSA-LCPAPSAKVIKMPRGGPQQLGTG 1449
Query: 1623 QHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGY 1682
+ P R+FVAL DY+P+ MS N A EEEL F++ Q+L+V+G +D FY E + G
Sbjct: 1450 ANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGN 1509
Query: 1683 IPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSKKA 1742
IP +VAE+ V G +Q R + SP G+ P V G
Sbjct: 1510 IPGRLVAEMEV----GTEQT-DRRWRSP-----AQGHLPSVAHLEDFQG---------LT 1550
Query: 1743 ESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFG 1802
+G + G K +P L P M+AA DY+P + + L RAGDV+ V+G
Sbjct: 1551 IPQGSSLVLQGNSKRLP---LWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYG 1607
Query: 1803 GMDDDGFYYGELNGQRGLVPSNFLE 1827
MDD GFYYGEL G RGLVP++ L+
Sbjct: 1608 PMDDQGFYYGELGGHRGLVPAHLLD 1632
Score = 70.5 bits (171), Expect = 1e-11
Identities = 36/59 (61%), Positives = 44/59 (74%), Gaps = 2/59 (3%)
Query: 1770 VAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGEL-NGQRGLVPSNFLE 1827
+A ++YNP E PN E ELP AGD I +FG MD+DGFY GEL +G+RGLVPSNF+E
Sbjct: 838 MAQYNYNPFEG-PNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVE 895
Score = 58.2 bits (139), Expect = 8e-08
Identities = 65/219 (29%), Positives = 90/219 (41%), Gaps = 41/219 (18%)
Query: 1540 PKANSGPKPY----PRLPAWEKGE------PERRGRSA-------TGRAKEPLSRATETG 1582
PK ++ P+ Y P EK E P G SA T A +PLS+ T +
Sbjct: 723 PKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQ 782
Query: 1583 EARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETLAYQH--------LPVRIFVALF 1634
+GS + R + +E+ S +LA + ++IF+A +
Sbjct: 783 SNSSSEGS-MWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQY 841
Query: 1635 DYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGE-GGGRTGYIPCNMVAEV-- 1691
+Y+P PN D E ELP G + +FGD D DGFY+GE GR G +P N V ++
Sbjct: 842 NYNPFE-GPN-DHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPD 899
Query: 1692 --------AVDSPAGRQQLL--QRGYLSPDILLEGSGNG 1720
A G QL Q L D LL G G
Sbjct: 900 SYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQG 938
Score = 48.9 bits (115), Expect = 5e-05
Identities = 24/65 (36%), Positives = 40/65 (61%), Gaps = 2/65 (3%)
Query: 656 QVFLARYSYNPFEGP-NENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNF 714
++ +A Y+P +G + L L AG+ + +YG MD+ GF+ GEL G RGLVP++
Sbjct: 1572 KIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGEL-GGHRGLVPAHL 1630
Query: 715 VERVS 719
++ +S
Sbjct: 1631 LDHMS 1635
Score = 48.1 bits (113), Expect = 8e-05
Identities = 86/370 (23%), Positives = 141/370 (38%), Gaps = 63/370 (17%)
Query: 296 PGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLE 355
P P L A P +P A + L + E E E+ + E R++ L
Sbjct: 6 PSP-LGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARER--QLR 62
Query: 356 QEARKKQRR-CEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVT 414
+EA +++R+ + L + ++ R ++E + A ++ + W+ AE R +
Sbjct: 63 EEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLH 122
Query: 415 QERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQ 474
+ERD +R+++ LQ +L E+++ R R EV Q R RLQ+
Sbjct: 123 RERDGVVRQARELQRQL--AEELVN--RGHCSRPGASEVSAAQCRC----------RLQE 168
Query: 475 AQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDL 534
A+ + + +G AR+R L Q + E+ L L FR HP
Sbjct: 169 VLAQLRWQTDG----------EQAARIRYL--QAALEVERQLFLKYILAHFRGHP----- 211
Query: 535 LTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRC-TPK-----SSEPAPA 588
+L P P S+ +P LP S G C PK S + +
Sbjct: 212 --------ALSGSPDPQAVHSLEEP----------LPQTSSGSCHAPKPACQLGSLDSLS 253
Query: 589 TLTGVPRRTAKKAESLSNSSHSE--SIHNSPKSCPTPEVDTASEVEEL--EADSVSLLPA 644
GV R+ S +SS S H S C P + + +A P+
Sbjct: 254 AEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPS 313
Query: 645 APEGSRGGAR 654
+P+ S G+R
Sbjct: 314 SPDTSTPGSR 323
Score = 46.2 bits (108), Expect = 3e-04
Identities = 22/66 (33%), Positives = 35/66 (53%), Gaps = 1/66 (1%)
Query: 1628 RIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNM 1687
+I +A DYDP G+ L R G ++ V+G D GFY GE GG G +P ++
Sbjct: 1572 KIMIAALDYDPGDGQMGGQ-GKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHL 1630
Query: 1688 VAEVAV 1693
+ +++
Sbjct: 1631 LDHMSL 1636
Score = 45.1 bits (105), Expect = 7e-04
Identities = 66/247 (26%), Positives = 108/247 (43%), Gaps = 19/247 (7%)
Query: 114 LNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIA 173
LN+ DR E R + L QR +L++ N ++PE + + ++ +
Sbjct: 520 LNVRDLDRLQRESQREVLRL-QRQLMLQQGNG----GAWPEAGGQSATCEEVRRQMLALE 574
Query: 174 KRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAA 233
+ L++R R+ QE L +AP R G E +A + A L+E L AK +
Sbjct: 575 RELDQRRRECQE--LGTQAAPARRRGEEAETQLQAALLKNAW-LAEENGRLQAKTDWVRK 631
Query: 234 LQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPS 293
++ E E++ L +E + + +LL+++ R R Q+Q+ Q+ L PS
Sbjct: 632 VEAENSEVRGHLGRACQERDASGLIAE--QLLQQAARGQDR-QQQLQRDPQKALCDLHPS 688
Query: 294 WPPGPALQARAGAPAPGAPGEAT----PQEDADNLPVILGEPEKEQRVQQLESELSKKRK 349
W ALQ R G P P P E + Q P PE + V Q ++ +KR+
Sbjct: 689 WKEIQALQCRPGHP-PEQPWETSQMPESQVKGSRRPKFHARPE-DYAVSQPNRDIQEKRE 746
Query: 350 KCESLEQ 356
SLE+
Sbjct: 747 --ASLEE 751
Score = 37.4 bits (85), Expect = 0.14
Identities = 60/258 (23%), Positives = 100/258 (38%), Gaps = 35/258 (13%)
Query: 289 PLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKR 348
PLPP PP P+ + P G E+ P E P LG E + L L
Sbjct: 331 PLPP--PPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLA 388
Query: 349 KKCESLEQEARKKQRR-CE-ELELQLRQAQNENARLVEENSRLSGRATEKEQVEWE--NA 404
++C +L++E ++ +R C + + ++++ + + A L RL+ RA E ++ +A
Sbjct: 389 RRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARELQETNLRAVSA 448
Query: 405 ELRGQ-LLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLS-- 461
+ G+ G+ + A ++++ L + + K + E+ Q L+ S
Sbjct: 449 PIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDL 508
Query: 462 --------------------LREKQEEVRR------LQQAQAEAQREHEGAVQLLESTLD 495
RE Q EV R LQQ A E G E
Sbjct: 509 HTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRR 568
Query: 496 SMQARVRELEEQCRSQTE 513
M A REL+++ R E
Sbjct: 569 QMLALERELDQRRRECQE 586
>gi|191252806 RIMS binding protein 3C [Homo sapiens]
Length = 1639
Score = 369 bits (946), Expect = e-101
Identities = 367/1148 (31%), Positives = 519/1148 (45%), Gaps = 220/1148 (19%)
Query: 123 NLELLRALGELRQRCAILKEENQMLRKSSFP-ETEEKVRRLKRKNAELAVIAKRLEERAR 181
N L +AL L +RC L+EEN+ LR++ P + +EKV+RLK K AEL +A+RL +RAR
Sbjct: 377 NWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRAR 436
Query: 182 KLQETNLRVVSAPLPRPGTS-LELCRKALARQRARDLSETASALLAKDKQIAALQRECRE 240
+LQETNLR VSAP+P + LELC+ ARQRARDLSE ASA LAKDKQI L++EC
Sbjct: 437 ELQETNLRAVSAPIPGESCAGLELCQ-VFARQRARDLSEQASAPLAKDKQIEELRQECHL 495
Query: 241 LQARLTL-------VGKEGP--QWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLP 291
LQAR+ G+ GP QWL+VRD DRL RESQREVLRLQRQ+ L+
Sbjct: 496 LQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQ--------- 546
Query: 292 PSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKC 351
Q GA P A G++ E E +++ LE EL ++R++C
Sbjct: 547 ---------QGNGGA-WPEAGGQSATCE------------EVRRQMLALERELDQRRREC 584
Query: 352 ESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLL 411
+ L +A +RR EE E QL+ A +NA L EEN RL + +VE EN+E+RG L
Sbjct: 585 QELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLG 644
Query: 412 GVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRR 471
QERD++ GL + EQ+L+ R+QQL+ + ++A L +E++
Sbjct: 645 RACQERDAS-----GLIA-----EQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQA 694
Query: 472 LQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR---LH 528
LQ + Q+ ES + R + R + S +++Q R L
Sbjct: 695 LQCRPGHPPEQPWETSQMPESQVKGS----RRPKFHARPEDYAVSQPNRDIQEKREASLE 750
Query: 529 PGPLDLLTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPA 588
P+ L SA S+PQ SE PA
Sbjct: 751 ESPVALGESA----------------SVPQ-----------------------VSETVPA 771
Query: 589 TLTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSL-LPAAPE 647
+ + +KK S SNSS S+ + S PT + DTASEV++LE DSVSL L
Sbjct: 772 S-----QPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGS 826
Query: 648 GSRGGARIQVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRR 707
+ ++++F+A+Y+YNPFEGPN++PE ELPLTAG+YIYI+G+MDEDGF+EGEL DGRR
Sbjct: 827 AAPAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRR 886
Query: 708 GLVPSNFVERVSDDDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRP 767
GLVPSNFVE++ D + LP + DL G S + Q
Sbjct: 887 GLVPSNFVEQIPDSYIPGCLPAKSPDL---------------------GPSQLPAGQDEA 925
Query: 768 EEEDAGDELSLSPSPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICV 827
EED+ LS +G+ + R L + ++ +A E + E C
Sbjct: 926 LEEDS----LLSGKAQGMVD-------RGLCQMVRVGSKTEVATEILDTKTE-----ACQ 969
Query: 828 NGELRQALGPGAPPKAVLENLD-LWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPS 886
G L Q++G + +L L P+ + +Q +T+ +S + + VV
Sbjct: 970 LG-LLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTA--TSANITWVYSSHRHPHVVYL 1026
Query: 887 QLRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVE 946
R H LT G H P YW T + V
Sbjct: 1027 DDREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTM---------SSTVT 1077
Query: 947 AQLPPQGPWEPGWERLEQRAAT---LQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPV 1003
GP P + L +R A+ L + LP A G S G+ + +
Sbjct: 1078 FDTLLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSA--------GSSNGVQVTGY--- 1126
Query: 1004 TIDAAGTSNGVRVTGYAIYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPH 1063
A ++G++V A G ++E SQLQ+ ++V VRTMS
Sbjct: 1127 ----AVYADGLKVCEVADATAGSTVLE------------FSQLQVPLTWQKVSVRTMSLC 1170
Query: 1064 GESADSIPAPITPALA-----PASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQH 1118
GES DS+PA I P + P +C GDPS+ +
Sbjct: 1171 GESLDSVPAQIPEDFFMCHRWPETPPFSYTC--------------------GDPST-YRV 1209
Query: 1119 PAPLGTQEPPGAPPASPSREMAKGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKD 1178
P+ Q+ APP++ + GS +P A + A R + S LG +
Sbjct: 1210 TFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLE-----AFFEEPPRRQSPVSNLGSEG 1264
Query: 1179 --PGPAAPSLAKQEAEWTAGEACPASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKED 1236
P A S A++ AE A E C Q + P + Q G+ + + +
Sbjct: 1265 ECPSSGAGSQAQELAE--AWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTSKS 1322
Query: 1237 TAELGVHL 1244
A +HL
Sbjct: 1323 PAPGFIHL 1330
Score = 127 bits (318), Expect = 1e-28
Identities = 97/265 (36%), Positives = 130/265 (49%), Gaps = 37/265 (13%)
Query: 1577 RATETGEARGQDGSGRRGPQ----KRGVRVLRPSTAELVPARS----------PSETLAY 1622
R TE E R + R Q KRG ++ PS+A L PA S P +
Sbjct: 1391 RGTERREERREPEPHSRQGQALGVKRGCQLHEPSSA-LCPAPSAKVIKMPRGGPQQLGTG 1449
Query: 1623 QHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGY 1682
+ P R+FVAL DY+P+ MS N A EEEL F++ Q+L+V+G +D FY E + G
Sbjct: 1450 ANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGN 1509
Query: 1683 IPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSKKA 1742
IP +VAE+ V G +Q R + SP G+ P V G
Sbjct: 1510 IPGRLVAEMEV----GTEQT-DRRWRSP-----AQGHLPSVAHLEDFQG---------LI 1550
Query: 1743 ESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFG 1802
+G + G K +P L P M+AA DY+P + + L RAGDV+ V+G
Sbjct: 1551 IPQGSSLVLQGNSKRLP---LWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYG 1607
Query: 1803 GMDDDGFYYGELNGQRGLVPSNFLE 1827
MDD GFYYGEL G RGLVP++ L+
Sbjct: 1608 PMDDQGFYYGELGGHRGLVPAHLLD 1632
Score = 70.5 bits (171), Expect = 1e-11
Identities = 36/59 (61%), Positives = 44/59 (74%), Gaps = 2/59 (3%)
Query: 1770 VAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGEL-NGQRGLVPSNFLE 1827
+A ++YNP E PN E ELP AGD I +FG MD+DGFY GEL +G+RGLVPSNF+E
Sbjct: 838 MAQYNYNPFEG-PNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVE 895
Score = 58.2 bits (139), Expect = 8e-08
Identities = 65/219 (29%), Positives = 90/219 (41%), Gaps = 41/219 (18%)
Query: 1540 PKANSGPKPY----PRLPAWEKGE------PERRGRSA-------TGRAKEPLSRATETG 1582
PK ++ P+ Y P EK E P G SA T A +PLS+ T +
Sbjct: 723 PKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQ 782
Query: 1583 EARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETLAYQH--------LPVRIFVALF 1634
+GS + R + +E+ S +LA + ++IF+A +
Sbjct: 783 SNSSSEGS-MWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQY 841
Query: 1635 DYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGE-GGGRTGYIPCNMVAEV-- 1691
+Y+P PN D E ELP G + +FGD D DGFY+GE GR G +P N V ++
Sbjct: 842 NYNPFE-GPN-DHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPD 899
Query: 1692 --------AVDSPAGRQQLL--QRGYLSPDILLEGSGNG 1720
A G QL Q L D LL G G
Sbjct: 900 SYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQG 938
Score = 48.9 bits (115), Expect = 5e-05
Identities = 24/65 (36%), Positives = 40/65 (61%), Gaps = 2/65 (3%)
Query: 656 QVFLARYSYNPFEGP-NENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNF 714
++ +A Y+P +G + L L AG+ + +YG MD+ GF+ GEL G RGLVP++
Sbjct: 1572 KIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGEL-GGHRGLVPAHL 1630
Query: 715 VERVS 719
++ +S
Sbjct: 1631 LDHMS 1635
Score = 48.1 bits (113), Expect = 8e-05
Identities = 86/370 (23%), Positives = 141/370 (38%), Gaps = 63/370 (17%)
Query: 296 PGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLE 355
P P L A P +P A + L + E E E+ + E R++ L
Sbjct: 6 PSP-LGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARER--QLR 62
Query: 356 QEARKKQRR-CEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVT 414
+EA +++R+ + L + ++ R ++E + A ++ + W+ AE R +
Sbjct: 63 EEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLH 122
Query: 415 QERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQ 474
+ERD +R+++ LQ +L E+++ R R EV Q R RLQ+
Sbjct: 123 RERDGVVRQARELQRQL--AEELVN--RGHCSRPGASEVSAAQCRC----------RLQE 168
Query: 475 AQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDL 534
A+ + + +G AR+R L Q + E+ L L FR HP
Sbjct: 169 VLAQLRWQTDG----------EQAARIRYL--QAALEVERQLFLKYILAHFRGHP----- 211
Query: 535 LTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRC-TPK-----SSEPAPA 588
+L P P S+ +P LP S G C PK S + +
Sbjct: 212 --------ALSGSPDPQAVHSLEEP----------LPQTSSGSCHAPKPACQLGSLDSLS 253
Query: 589 TLTGVPRRTAKKAESLSNSSHSE--SIHNSPKSCPTPEVDTASEVEEL--EADSVSLLPA 644
GV R+ S +SS S H S C P + + +A P+
Sbjct: 254 AEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPS 313
Query: 645 APEGSRGGAR 654
+P+ S G+R
Sbjct: 314 SPDTSTPGSR 323
Score = 46.2 bits (108), Expect = 3e-04
Identities = 22/66 (33%), Positives = 35/66 (53%), Gaps = 1/66 (1%)
Query: 1628 RIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNM 1687
+I +A DYDP G+ L R G ++ V+G D GFY GE GG G +P ++
Sbjct: 1572 KIMIAALDYDPGDGQMGGQ-GKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHL 1630
Query: 1688 VAEVAV 1693
+ +++
Sbjct: 1631 LDHMSL 1636
Score = 45.1 bits (105), Expect = 7e-04
Identities = 66/247 (26%), Positives = 108/247 (43%), Gaps = 19/247 (7%)
Query: 114 LNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIA 173
LN+ DR E R + L QR +L++ N ++PE + + ++ +
Sbjct: 520 LNVRDLDRLQRESQREVLRL-QRQLMLQQGNG----GAWPEAGGQSATCEEVRRQMLALE 574
Query: 174 KRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAA 233
+ L++R R+ QE L +AP R G E +A + A L+E L AK +
Sbjct: 575 RELDQRRRECQE--LGTQAAPARRRGEEAETQLQAALLKNAW-LAEENGRLQAKTDWVRK 631
Query: 234 LQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPS 293
++ E E++ L +E + + +LL+++ R R Q+Q+ Q+ L PS
Sbjct: 632 VEAENSEVRGHLGRACQERDASGLIAE--QLLQQAARGQDR-QQQLQRDPQKALCDLHPS 688
Query: 294 WPPGPALQARAGAPAPGAPGEAT----PQEDADNLPVILGEPEKEQRVQQLESELSKKRK 349
W ALQ R G P P P E + Q P PE + V Q ++ +KR+
Sbjct: 689 WKEIQALQCRPGHP-PEQPWETSQMPESQVKGSRRPKFHARPE-DYAVSQPNRDIQEKRE 746
Query: 350 KCESLEQ 356
SLE+
Sbjct: 747 --ASLEE 751
Score = 37.4 bits (85), Expect = 0.14
Identities = 60/258 (23%), Positives = 100/258 (38%), Gaps = 35/258 (13%)
Query: 289 PLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKR 348
PLPP PP P+ + P G E+ P E P LG E + L L
Sbjct: 331 PLPP--PPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLA 388
Query: 349 KKCESLEQEARKKQRR-CE-ELELQLRQAQNENARLVEENSRLSGRATEKEQVEWE--NA 404
++C +L++E ++ +R C + + ++++ + + A L RL+ RA E ++ +A
Sbjct: 389 RRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARELQETNLRAVSA 448
Query: 405 ELRGQ-LLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLS-- 461
+ G+ G+ + A ++++ L + + K + E+ Q L+ S
Sbjct: 449 PIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDL 508
Query: 462 --------------------LREKQEEVRR------LQQAQAEAQREHEGAVQLLESTLD 495
RE Q EV R LQQ A E G E
Sbjct: 509 HTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRR 568
Query: 496 SMQARVRELEEQCRSQTE 513
M A REL+++ R E
Sbjct: 569 QMLALERELDQRRRECQE 586
>gi|153792195 DKFZP434H0735 protein [Homo sapiens]
Length = 1639
Score = 369 bits (946), Expect = e-101
Identities = 377/1203 (31%), Positives = 531/1203 (44%), Gaps = 219/1203 (18%)
Query: 123 NLELLRALGELRQRCAILKEENQMLRKSSFP-ETEEKVRRLKRKNAELAVIAKRLEERAR 181
N L +AL L +RC L+ EN+ LR++ P + +EKV+RLK K AEL +A+RL +RAR
Sbjct: 377 NWLLAKALWVLARRCYTLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRAR 436
Query: 182 KLQETNLRVVSAPLPRPGTS-LELCRKALARQRARDLSETASALLAKDKQIAALQRECRE 240
KLQETNLR VSAP+P + LELC+ ARQRARDLSE ASA LAKDKQI L++EC
Sbjct: 437 KLQETNLRAVSAPIPGESCAGLELCQ-VFARQRARDLSEQASAPLAKDKQIEELRQECHL 495
Query: 241 LQARLTL-------VGKEGP--QWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLP 291
LQAR+ G+ GP QWL+VRD DRL RESQREVLRLQRQ+ L+
Sbjct: 496 LQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQ--------- 546
Query: 292 PSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKC 351
Q GA P A G++ E E +++ LE EL ++R++C
Sbjct: 547 ---------QGNGGA-WPEAGGQSATCE------------EVRRQMLALERELDQRRREC 584
Query: 352 ESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLL 411
+ L +A +RR EE E QL+ A +NA L EEN RL + +VE EN+E+RG L
Sbjct: 585 QELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLG 644
Query: 412 GVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRR 471
QERD++ GL + EQ+L+ R+QQL+ + ++A L +E++
Sbjct: 645 RACQERDAS-----GLIA-----EQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQA 694
Query: 472 LQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR---LH 528
LQ + Q+ ES + R + R + S +++Q R L
Sbjct: 695 LQCRPGHPPEQPWETSQMPESQVKGS----RRPKFHARPEDYAVSQPNRDIQEKREASLE 750
Query: 529 PGPLDLLTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPA 588
P+ L SA S+PQ SE PA
Sbjct: 751 ESPVALGESA----------------SVPQ-----------------------VSETVPA 771
Query: 589 TLTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSL-LPAAPE 647
+ + +KK S SNSS S+ + S PT + DTASEV++LE DSVSL L
Sbjct: 772 S-----QPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGS 826
Query: 648 GSRGGARIQVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRR 707
+ ++++F+A+Y+YNPFEGPN++PE ELPLTAG+YIYI+G+MDEDGF+EGEL DGRR
Sbjct: 827 AAPAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRR 886
Query: 708 GLVPSNFVERVSDDDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRP 767
GLVPSNFVE++ D + LP + DL G S + Q
Sbjct: 887 GLVPSNFVEQIPDSYIPGCLPAKSPDL---------------------GPSQLPAGQDEA 925
Query: 768 EEEDAGDELSLSPSPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICV 827
EED+ LS +G+ + R L + ++ +A E + E C
Sbjct: 926 LEEDS----LLSGKAQGVVD-------RGLCQMVRVGSKTEVATEILDTKTE-----ACQ 969
Query: 828 NGELRQALGPGAPPKAVLENLD-LWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPS 886
G L Q++G + +L L P+ + +Q +T+ +S + + VV
Sbjct: 970 LG-LLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTA--TSANITWVYSSHRHPHVVYL 1026
Query: 887 QLRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVE 946
R H LT G H P YW T + V
Sbjct: 1027 DDREHALTPAGVSCYTFQGLCPGTHYRARVEVRLPRDLLQVYWGTM---------SSTVT 1077
Query: 947 AQLPPQGPWEPGWERLEQRAAT---LQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPV 1003
GP P + L +R A+ L + LP A G S G+ + +
Sbjct: 1078 FDTLLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSA--------GSSNGVQVTGY--- 1126
Query: 1004 TIDAAGTSNGVRVTGYAIYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPH 1063
A ++G++V A G ++E SQLQ+ ++V VRTMS
Sbjct: 1127 ----AVYADGLKVCEVADATAGSTLLE------------FSQLQVPLTWQKVSVRTMSLC 1170
Query: 1064 GESADSIPAPIT---------PALAPASLPA------RVSCPSPHPSPEARAPLASASP- 1107
GES DS+PA I P P S RV+ P P A ASP
Sbjct: 1171 GESLDSVPAQIPEDFFMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLSLAPPSAKASPH 1230
Query: 1108 GPGDPSSPLQHPAPLGTQEPPGAPPASPSREM-AKGSHEDPPAPCSQEEAGAAVLGTSEE 1166
PG P +EPP SP + ++G A +E A G ++
Sbjct: 1231 NPGSCGEPQAKFLEAFFEEPPRR--QSPVSNLGSEGECPSSGAGSQAQELAEAWEGCRKD 1288
Query: 1167 RTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACPASSSTQGARAQQAPNTEMCQGGDPGS 1226
S + P + K+ G + + R + P E CQ + +
Sbjct: 1289 LLFQKSPQNHRPPSVSDQPGEKENCSQHMGTSKSPAPGFIHLRTECGPRKEPCQ--EKAA 1346
Query: 1227 GLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDIQEEEEE-----------EEEEEEEEL 1275
R +K+D + + + SD ++ +EE+E EE E E
Sbjct: 1347 LERVLRQKQDAQGFTPPQLGASQQYA--SDFHNVLKEEQEALCLDLWGTERREERREPEP 1404
Query: 1276 GSR 1278
SR
Sbjct: 1405 HSR 1407
Score = 128 bits (322), Expect = 5e-29
Identities = 95/261 (36%), Positives = 127/261 (48%), Gaps = 33/261 (12%)
Query: 1577 RATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARS----------PSETLAYQHLP 1626
R E E G+ KRG ++ PS+A L PA S P + + P
Sbjct: 1395 RREERREPEPHSRQGQALGVKRGCQLHEPSSA-LCPAPSAKVIKMPRGGPQQLGTGANTP 1453
Query: 1627 VRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCN 1686
R+FVAL DY+P+ MS N A EEEL F++ Q+L+V+G +D FY E + G IP
Sbjct: 1454 ARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGR 1513
Query: 1687 MVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSKKAESEG 1746
+VAE+ V G +Q R + SP GN P V G +G
Sbjct: 1514 LVAEMEV----GTEQT-DRRWRSP-----AQGNLPSVAHLEDFQG---------LTIPQG 1554
Query: 1747 PAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDD 1806
+ G K +P L P M+AA DY+P + + L RAGDV+ V+G MDD
Sbjct: 1555 SSLVLQGNSKRLP---LWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDD 1611
Query: 1807 DGFYYGELNGQRGLVPSNFLE 1827
GFYYGEL G RGLVP++ L+
Sbjct: 1612 QGFYYGELGGHRGLVPAHLLD 1632
Score = 70.5 bits (171), Expect = 1e-11
Identities = 36/59 (61%), Positives = 44/59 (74%), Gaps = 2/59 (3%)
Query: 1770 VAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGEL-NGQRGLVPSNFLE 1827
+A ++YNP E PN E ELP AGD I +FG MD+DGFY GEL +G+RGLVPSNF+E
Sbjct: 838 MAQYNYNPFEG-PNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVE 895
Score = 57.8 bits (138), Expect = 1e-07
Identities = 65/219 (29%), Positives = 90/219 (41%), Gaps = 41/219 (18%)
Query: 1540 PKANSGPKPY----PRLPAWEKGE------PERRGRSA-------TGRAKEPLSRATETG 1582
PK ++ P+ Y P EK E P G SA T A +PLS+ T +
Sbjct: 723 PKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQ 782
Query: 1583 EARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETLAYQH--------LPVRIFVALF 1634
+GS + R + +E+ S +LA + ++IF+A +
Sbjct: 783 SNSSSEGS-MWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQY 841
Query: 1635 DYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGE-GGGRTGYIPCNMVAEV-- 1691
+Y+P PN D E ELP G + +FGD D DGFY+GE GR G +P N V ++
Sbjct: 842 NYNPFE-GPN-DHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQIPD 899
Query: 1692 --------AVDSPAGRQQLL--QRGYLSPDILLEGSGNG 1720
A G QL Q L D LL G G
Sbjct: 900 SYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQG 938
Score = 48.9 bits (115), Expect = 5e-05
Identities = 24/65 (36%), Positives = 40/65 (61%), Gaps = 2/65 (3%)
Query: 656 QVFLARYSYNPFEGP-NENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNF 714
++ +A Y+P +G + L L AG+ + +YG MD+ GF+ GEL G RGLVP++
Sbjct: 1572 KIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGEL-GGHRGLVPAHL 1630
Query: 715 VERVS 719
++ +S
Sbjct: 1631 LDHMS 1635
Score = 48.1 bits (113), Expect = 8e-05
Identities = 86/370 (23%), Positives = 141/370 (38%), Gaps = 63/370 (17%)
Query: 296 PGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLE 355
P P L A P +P A + L + E E E+ + E R++ L
Sbjct: 6 PSP-LGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARER--QLR 62
Query: 356 QEARKKQRR-CEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVT 414
+EA +++R+ + L + ++ R ++E + A ++ + W+ AE R +
Sbjct: 63 EEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLH 122
Query: 415 QERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQ 474
+ERD +R+++ LQ +L E+++ R R EV Q R RLQ+
Sbjct: 123 RERDGVVRQARELQRQL--AEELVN--RGHCSRPGASEVSAAQCRC----------RLQE 168
Query: 475 AQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDL 534
A+ + + +G AR+R L Q + E+ L L FR HP
Sbjct: 169 VLAQLRWQTDG----------EQAARIRYL--QAALEVERQLFLKYILAHFRGHP----- 211
Query: 535 LTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRC-TPK-----SSEPAPA 588
+L P P S+ +P LP S G C PK S + +
Sbjct: 212 --------ALSGSPDPQAVHSLEEP----------LPQTSSGSCHAPKPACQLGSLDSLS 253
Query: 589 TLTGVPRRTAKKAESLSNSSHSE--SIHNSPKSCPTPEVDTASEVEEL--EADSVSLLPA 644
GV R+ S +SS S H S C P + + +A P+
Sbjct: 254 AEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPS 313
Query: 645 APEGSRGGAR 654
+P+ S G+R
Sbjct: 314 SPDTSTPGSR 323
Score = 46.2 bits (108), Expect = 3e-04
Identities = 22/66 (33%), Positives = 35/66 (53%), Gaps = 1/66 (1%)
Query: 1628 RIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNM 1687
+I +A DYDP G+ L R G ++ V+G D GFY GE GG G +P ++
Sbjct: 1572 KIMIAALDYDPGDGQMGGQ-GKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHL 1630
Query: 1688 VAEVAV 1693
+ +++
Sbjct: 1631 LDHMSL 1636
Score = 45.1 bits (105), Expect = 7e-04
Identities = 66/247 (26%), Positives = 108/247 (43%), Gaps = 19/247 (7%)
Query: 114 LNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIA 173
LN+ DR E R + L QR +L++ N ++PE + + ++ +
Sbjct: 520 LNVRDLDRLQRESQREVLRL-QRQLMLQQGNG----GAWPEAGGQSATCEEVRRQMLALE 574
Query: 174 KRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAA 233
+ L++R R+ QE L +AP R G E +A + A L+E L AK +
Sbjct: 575 RELDQRRRECQE--LGAQAAPARRRGEEAETQLQAALLKNAW-LAEENGRLQAKTDWVRK 631
Query: 234 LQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPS 293
++ E E++ L +E + + +LL+++ R R Q+Q+ Q+ L PS
Sbjct: 632 VEAENSEVRGHLGRACQERDASGLIAE--QLLQQAARGQDR-QQQLQRDPQKALCDLHPS 688
Query: 294 WPPGPALQARAGAPAPGAPGEAT----PQEDADNLPVILGEPEKEQRVQQLESELSKKRK 349
W ALQ R G P P P E + Q P PE + V Q ++ +KR+
Sbjct: 689 WKEIQALQCRPGHP-PEQPWETSQMPESQVKGSRRPKFHARPE-DYAVSQPNRDIQEKRE 746
Query: 350 KCESLEQ 356
SLE+
Sbjct: 747 --ASLEE 751
Score = 34.7 bits (78), Expect = 0.89
Identities = 59/258 (22%), Positives = 99/258 (38%), Gaps = 35/258 (13%)
Query: 289 PLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKR 348
PLPP PP P+ + P G E+ P E P LG E + L L
Sbjct: 331 PLPP--PPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLA 388
Query: 349 KKCESLEQEARKKQRR-CE-ELELQLRQAQNENARLVEENSRLSGRATEKEQVEWE--NA 404
++C +L+ E ++ +R C + + ++++ + + A L RL+ RA + ++ +A
Sbjct: 389 RRCYTLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARKLQETNLRAVSA 448
Query: 405 ELRGQ-LLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLS-- 461
+ G+ G+ + A ++++ L + + K + E+ Q L+ S
Sbjct: 449 PIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDL 508
Query: 462 --------------------LREKQEEVRR------LQQAQAEAQREHEGAVQLLESTLD 495
RE Q EV R LQQ A E G E
Sbjct: 509 HTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRR 568
Query: 496 SMQARVRELEEQCRSQTE 513
M A REL+++ R E
Sbjct: 569 QMLALERELDQRRRECQE 586
>gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo
sapiens]
Length = 1002
Score = 81.3 bits (199), Expect = 8e-15
Identities = 121/448 (27%), Positives = 193/448 (43%), Gaps = 65/448 (14%)
Query: 120 DRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEER 179
DR N EL + LR + N+ L++ E EEK+R L + A + + LEE
Sbjct: 283 DRYNKELTKERDALRLELYKNTQSNEDLKQEK-SELEEKLRVLVTEKAGMQL---NLEEL 338
Query: 180 ARKLQETNLRV--VSAPLPRPGTSLELC-----RKALARQRARDLSETASALLAKDKQIA 232
+KL+ T L + S+ P + +L R L + + + +DK
Sbjct: 339 QKKLEMTELLLQQFSSRCEAPDANQQLQQAMEERAQLEAHLGQVMESVRQLQMERDKYAE 398
Query: 233 ALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRE----SQREVLRLQRQIA-LRNQRET 287
L+ E + R+ + ++ +H LRE S V L+ +A LRNQ
Sbjct: 399 NLKGESAMWRQRMQQMSEQ----VHT------LREEKECSMSRVQELETSLAELRNQMAE 448
Query: 288 LPLPPSWPPGPA-----LQARAG---APAPGAPGEATPQ-EDADNLPVILGEPEKE---- 334
P PP P GP+ LQA A G G+ Q +D + L + E E+
Sbjct: 449 PP-PPEPPAGPSEVEQQLQAEAEHLRKELEGLAGQLQAQVQDNEGLSRLNREQEERLLEL 507
Query: 335 QRVQQLESELSKKRKKCESLEQEARKKQRRC----EELELQLRQAQNENARLVEENSRLS 390
+R +L E ++ R++ Q R R EL+ QL + Q+ +L EN ++
Sbjct: 508 ERAAELWGEQAEARRQILETMQNDRTTISRALSQNRELKEQLAELQSGFVKLTNENMEIT 567
Query: 391 GRATEKEQVEWENAELRGQLLGVTQERDSALR-----KSQGLQSKLESLEQVLKHMREVA 445
++ V+ E G+ LG QE+ S L+ KSQ QS + +Q L H+++
Sbjct: 568 SALQSEQHVKRE----LGKKLGELQEKLSELKETVELKSQEAQSLQQQRDQYLGHLQQYV 623
Query: 446 QRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELE 505
QQL E E L + + V +LQQ +A+ + E A Q L+ T + ++A ++
Sbjct: 624 AAYQQLTSEKEVLHNQLLLQTQLVDQLQQQEAQGKAVAEMARQELQETQERLEAATQQ-N 682
Query: 506 EQCRSQTEQFSLLAQELQAFRLHPGPLD 533
+Q R+ Q SL+A HPG D
Sbjct: 683 QQLRA---QLSLMA--------HPGEGD 699
Score = 48.5 bits (114), Expect = 6e-05
Identities = 108/478 (22%), Positives = 188/478 (39%), Gaps = 68/478 (14%)
Query: 89 QQASSSGPACQRPE-DEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAI-LKEENQM 146
QQ SS C+ P+ +++++ ++ + + +E +R L R + A LK E+ M
Sbjct: 350 QQFSSR---CEAPDANQQLQQAMEERAQLEAHLGQVMESVRQLQMERDKYAENLKGESAM 406
Query: 147 LRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPG---TSLE 203
R+ + E+V L+ E R++E L E ++ P P P + +E
Sbjct: 407 WRQR-MQQMSEQVHTLRE---EKECSMSRVQELETSLAELRNQMAEPPPPEPPAGPSEVE 462
Query: 204 LCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDR 263
+A A ++L A L A+ + L R RE + RL + + W + R
Sbjct: 463 QQLQAEAEHLRKELEGLAGQLQAQVQDNEGLSRLNREQEERLLELERAAELWGEQAEARR 522
Query: 264 LLRES-QREVLRLQRQIALRNQRETLPLPPSWPPG------------PALQARAGAPAPG 310
+ E+ Q + + R AL RE G ALQ+
Sbjct: 523 QILETMQNDRTTISR--ALSQNRELKEQLAELQSGFVKLTNENMEITSALQSEQHVKREL 580
Query: 311 APGEATPQEDADNLP--VILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEEL 368
QE L V L E + QQ + L ++ + +Q +K+ +L
Sbjct: 581 GKKLGELQEKLSELKETVELKSQEAQSLQQQRDQYLGHLQQYVAAYQQLTSEKEVLHNQL 640
Query: 369 ELQLR-----QAQNENARLVEENSRLSGRATEK--EQVEWENAELRGQL--LGVTQERDS 419
LQ + Q Q + V E +R + T++ E +N +LR QL + E D
Sbjct: 641 LLQTQLVDQLQQQEAQGKAVAEMARQELQETQERLEAATQQNQQLRAQLSLMAHPGEGDG 700
Query: 420 ALRKSQGLQSKLE----SLEQVLKHMREVAQRRQQL---------EVEHEQARL--SLRE 464
R+ + + + E ++ Q + + E + R+ + E EQARL L+E
Sbjct: 701 LDREEEEDEEEEEEEAVAVPQPMPSIPEDLESREAMVAFFNSAVASAEEEQARLRGQLKE 760
Query: 465 KQEEVRRLQQAQAEAQREHEGAV---------------QLLESTLDSMQARVRELEEQ 507
++ RRL A AQ+E E A + L+ ++ +Q+R EL ++
Sbjct: 761 QRVRCRRLAHLLASAQKEPEAAAPAPGTGGDSVCGETHRALQGAMEKLQSRFMELMQE 818
Score = 40.8 bits (94), Expect = 0.012
Identities = 50/231 (21%), Positives = 85/231 (36%), Gaps = 34/231 (14%)
Query: 335 QRVQQLESELSKKRKKCESLEQEARKKQRRCEEL---------------------ELQLR 373
Q + L SE ++ + + AR+K+ E+L Q +
Sbjct: 221 QTIGILVSEKAELQTALAHTQHAARQKEGESEDLASRLQYSRRRVGELERALSAVSTQQK 280
Query: 374 QAQNENARLVEENS----RLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQS 429
+A N L +E L E ++ E +EL +L + E+ + LQ
Sbjct: 281 KADRYNKELTKERDALRLELYKNTQSNEDLKQEKSELEEKLRVLVTEKAGMQLNLEELQK 340
Query: 430 KLESLEQVLKHMR------EVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREH 483
KLE E +L+ + Q+ QQ E Q L + E VR+LQ + +
Sbjct: 341 KLEMTELLLQQFSSRCEAPDANQQLQQAMEERAQLEAHLGQVMESVRQLQMERDKYAENL 400
Query: 484 EGAVQLLESTLDSMQARV---RELEEQCRSQTEQFSLLAQELQAFRLHPGP 531
+G + + M +V RE +E S+ ++ EL+ P P
Sbjct: 401 KGESAMWRQRMQQMSEQVHTLREEKECSMSRVQELETSLAELRNQMAEPPP 451
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 81.3 bits (199), Expect = 8e-15
Identities = 112/446 (25%), Positives = 189/446 (42%), Gaps = 50/446 (11%)
Query: 81 EACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAIL 140
E L ++ P QR EE E K + EL R E Q+ L
Sbjct: 250 ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ---------ELRRERQEEEQQQQRL 300
Query: 141 KEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGT 200
+ E Q+ RK E++ R +++ +R ++ R+ +E + +
Sbjct: 301 RREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERR 360
Query: 201 SLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRD 260
+L R+ +R + L L +++Q+ Q+ RE Q R
Sbjct: 361 EQQLRREQEEERREQQLRREQQ--LRREQQLRREQQLRREQQLRRE-------------- 404
Query: 261 FDRLLRESQ-REVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQE 319
+L RE Q R +L+R+ LR ++E Q E +
Sbjct: 405 -QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQR--------LKREQEERR 455
Query: 320 DADNLPVILGEPEKEQRVQQLESELSKKRK-KCESLEQEARKKQRRCEELELQLRQAQNE 378
D E+E+R QQL+ + ++R+ + LE+E R++Q+ E +L+ Q +
Sbjct: 456 DWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERR 515
Query: 379 NARLV--EENSRLSGRATEKEQVEWENAELRGQLLGVTQER--DSALRKSQGLQSKLESL 434
RL EE RL R ++Q+ E E R QLL +E+ + R+ + + + E
Sbjct: 516 EQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERR 575
Query: 435 EQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQR------EHEGAVQ 488
+Q+LK RE +R+Q+L+ E E+ RL R K+EEV RL+Q + QR E E Q
Sbjct: 576 DQLLK--REEERRQQRLKREQEE-RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQ 632
Query: 489 LLESTLDSMQARVRELEEQCRSQTEQ 514
LL+S + + R ++L + + + EQ
Sbjct: 633 LLKSE-EQEERRQQQLRREQQERREQ 657
Score = 72.8 bits (177), Expect = 3e-12
Identities = 109/435 (25%), Positives = 187/435 (42%), Gaps = 31/435 (7%)
Query: 105 EVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKR 164
E ++ + +L R + EL R E ++R EE Q L+ ETEE +
Sbjct: 152 EEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQ-LQSCKGHETEEFPDEEQL 210
Query: 165 KNAELAVIAKR-LEERARKLQETNLRVVSAPLPRPGTSLE-LCRKALAR------QRARD 216
+ EL + ++ EE+ ++ +E RV + E + RK + QR R+
Sbjct: 211 RRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE 270
Query: 217 LSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQ 276
L E L ++Q L+RE +E + + + +E Q L R + RE Q E Q
Sbjct: 271 LQEEEEQLRKLERQ--ELRRERQEEEQQQQRLRRE--QQLR-RKQEEERREQQEERREQQ 325
Query: 277 RQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQR 336
+ + +R L Q R QE+ + E E+E+R
Sbjct: 326 ERREQQEERREQQLRREQEERREQQLRR------------EQEEERREQQLRREQEEERR 373
Query: 337 VQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEK 396
QQL E +R++ EQ+ R++Q+ E +L+ Q +L E + E+
Sbjct: 374 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433
Query: 397 EQVEWENAELRGQLLGVTQE--RDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVE 454
+ + E E R Q L QE RD R+ + + + E +Q LK +E +R + L++E
Sbjct: 434 HEQKHEQ-ERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLE 492
Query: 455 HEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRS--QT 512
E+ R +++++RR Q+ + E + + + + L+ L S Q RE EE+ +
Sbjct: 493 EEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR 552
Query: 513 EQFSLLAQELQAFRL 527
E+ L QE + RL
Sbjct: 553 EEEKRLEQERREQRL 567
Score = 67.0 bits (162), Expect = 2e-10
Identities = 121/475 (25%), Positives = 202/475 (42%), Gaps = 72/475 (15%)
Query: 99 QRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEK 158
+ PE+E + LK++ +R +L R E R++ +EE + L + E EE+
Sbjct: 623 EEPEEERRQQLLKSEEQE---ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEE 679
Query: 159 VRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQRARDLS 218
R + E +R++ R K Q ++ S R RK ++R ++
Sbjct: 680 RREQELAEEEQEQARERIKSRIPKWQ---WQLESEADARQSKVYSRPRKQEGQRRRQEQE 736
Query: 219 ETA----SALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDR-LLRESQREVL 273
E S L ++++ A Q++ E + T QW +R R S R L
Sbjct: 737 EKRRRRESELQWQEEERAHRQQQEEEQRRDFTW------QWQAEEKSERGRQRLSARPPL 790
Query: 274 RLQRQIALR----NQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQ----------- 318
R QR+ LR QRE LP + R E Q
Sbjct: 791 REQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850
Query: 319 EDADNLPVILGEPEKEQRVQ----------QLESELSKKRKKC---ESLEQEARKKQRRC 365
E+ D L E ++ +R Q QLE E ++R +L+++ RK+Q+
Sbjct: 851 EEEDGLQ----EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL 906
Query: 366 EELELQLRQAQNENARLVEENSRLSGRAT---EKEQVEWENAELRGQLLGVTQERDSALR 422
+E E +L++ + E R E+ + E+EQ+ E E R + QER+ R
Sbjct: 907 QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR-----QERERQYR 961
Query: 423 KSQGLQSKLESL--EQVLKHMREVAQR--RQQLEVEHEQARLSLREKQEEVRRLQ----- 473
K + LQ K E L E+ K R+ ++ R++ E++ E+ +L LRE++E+ RR +
Sbjct: 962 KDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQL-LREEREKRRRQEWERQY 1020
Query: 474 QAQAEAQREHEGAVQLLESTLDS--MQARVRELEEQCRSQTEQFSLLAQELQAFR 526
+ + E Q+E E QLL + +Q R R+ E+ Q E+ LL +E + R
Sbjct: 1021 RKKDELQQEEE---QLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRR 1072
Score = 63.2 bits (152), Expect = 2e-09
Identities = 50/187 (26%), Positives = 93/187 (49%), Gaps = 8/187 (4%)
Query: 333 KEQRVQQLESELSKKRKKCESLEQ-EARKKQRRCEELELQLRQAQNENARLVEENSRLSG 391
+ Q+ Q+ E EL++ ++ E E+ E R +QRR EEL Q ++ Q R EE S
Sbjct: 137 RRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSC 196
Query: 392 RATEKEQVEWENAELRGQLLGV----TQERDSALRKSQGLQSKLESLEQVLKHMREVAQR 447
+ E E+ E R +LL + +E+ R+ Q + E ++ K + +
Sbjct: 197 KGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKE 256
Query: 448 RQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQ 507
++L+ E Q + L+E++E++R+L++ + +R+ E + + L Q R+ EE+
Sbjct: 257 EEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEE---EQQQQRLRREQQLRRKQEEE 313
Query: 508 CRSQTEQ 514
R Q E+
Sbjct: 314 RREQQEE 320
Score = 62.8 bits (151), Expect = 3e-09
Identities = 110/423 (26%), Positives = 184/423 (43%), Gaps = 61/423 (14%)
Query: 125 ELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQ 184
+LLR E R+R + E Q +K + EE++ R +R+ +RL+ER R+ +
Sbjct: 1002 QLLREEREKRRR---QEWERQYRKKDELQQEEEQLLREEREK-------RRLQERERQYR 1051
Query: 185 ETNLRVVSAPLPRPGTSLELCRKA-LARQ--RARDLSETASALLAKDKQIAALQ---REC 238
E + G E R+ L RQ + +L + LL ++ + Q R+C
Sbjct: 1052 EEE-ELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQC 1110
Query: 239 RE---LQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWP 295
RE LQ + +E + ++ +R RE + EV + + Q+ LR +
Sbjct: 1111 REEEELQQEEEQLLREEREKRRRQELERQYREEE-EVQQEEEQL-LREE----------- 1157
Query: 296 PGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLE 355
P + R E QE+ L E+E+R Q+ E + ++ E L+
Sbjct: 1158 --PEKRRRQELERQYREEEELQQEEEQLL-----REEQEKRRQERERQYREE----EELQ 1206
Query: 356 QEARKKQRRCEELELQLR-QAQNENARLVEENSRLSGRATEKEQV-EWENAELRGQ---- 409
++ RK++ R E+ L+ Q + E V +N ++ + E EQ + E+++LR +
Sbjct: 1207 RQKRKQRYRDEDQRSDLKWQWEPEKENAVRDN-KVYCKGRENEQFRQLEDSQLRDRQSQQ 1265
Query: 410 ----LLGVTQERD--SALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR 463
LLG QERD R+ Q EQ+ + ++ A+RR + E +Q LR
Sbjct: 1266 DLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL---LR 1322
Query: 464 EKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQ 523
E++EE RR Q+ + RE E +Q E Q R R+ E+ EQ +E Q
Sbjct: 1323 EEREEKRRRQETDRKF-REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQ 1381
Query: 524 AFR 526
R
Sbjct: 1382 RLR 1384
Score = 62.4 bits (150), Expect = 4e-09
Identities = 107/481 (22%), Positives = 191/481 (39%), Gaps = 47/481 (9%)
Query: 89 QQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLR 148
QQ S +R ++E E LK + + L+ E R+ + +EE + +
Sbjct: 529 QQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQ 588
Query: 149 KSSFPETEEKVRRLKRKNAELAVIAKRLEERARK---LQETNLRVVSAPLPRPGTSLELC 205
+ + E +RLKR+ E +R E+R ++ +E +++ + +L
Sbjct: 589 RLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLR 648
Query: 206 RKALARQRAR----DLSETASALLAKDKQIAALQRECRE---LQARLTLVGKEGPQWLHV 258
R+ R+ R + E L ++ + ++E E QAR + + P+W
Sbjct: 649 REQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRI-PKWQWQ 707
Query: 259 RDFDRLLRES--------QREVLRLQRQIALRNQRET-LPLPPSWPPGPALQARAGAPAP 309
+ + R+S Q R Q Q R +RE+ L Q
Sbjct: 708 LESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDF 767
Query: 310 GAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKK---CESLEQEARKKQRRCE 366
+A + + + P +EQR +QL +E ++R++ E E+E R++QRR
Sbjct: 768 TWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRER 827
Query: 367 ELELQL-------------RQAQNENARLVEENSRLSGRATEKEQVEW-----ENAELRG 408
E ELQ +Q Q E L E+ R + ++Q +W E + R
Sbjct: 828 EKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ-KWRWQLEEERKRRR 886
Query: 409 QLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQ-- 466
L LRK Q L + E E++ + RE +R++Q E+ +L E+Q
Sbjct: 887 HTLYAKPALQEQLRKEQQLLQEEE--EELQREEREKRRRQEQERQYREEEQLQQEEEQLL 944
Query: 467 -EEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAF 525
EE + ++ + E Q + +Q E L + R +E+ + E+ L +E Q
Sbjct: 945 REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLL 1004
Query: 526 R 526
R
Sbjct: 1005 R 1005
Score = 61.6 bits (148), Expect = 7e-09
Identities = 106/444 (23%), Positives = 183/444 (41%), Gaps = 71/444 (15%)
Query: 121 RPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNA---ELAVIAKRLE 177
R L L E R+R + EE Q + PE EEK +R +++ EL + + +
Sbjct: 781 RQRLSARPPLREQRER-QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839
Query: 178 ----ERARKLQETNLRVVSAPLPRPGTSLELCRK-----ALARQRARDLSETASAL---L 225
ERA++LQE + R +K R+R R AL L
Sbjct: 840 LQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL 899
Query: 226 AKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQR 285
K++Q+ LQ E ELQ + Q R+ ++L +E + ++LR +R+ R +R
Sbjct: 900 RKEQQL--LQEEEEELQREEREKRRRQEQERQYREEEQLQQEEE-QLLREEREKRRRQER 956
Query: 286 ETLPLPPSWPPGPALQARAGAPAPGAPGEATPQE------DADNLPVILGEPEKEQRVQQ 339
E + LQ + P + QE + + L + +E+R ++
Sbjct: 957 ER-----QYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011
Query: 340 LESELSKKRKKCESLEQEAR------KKQRRCEELELQLRQA---QNENARLVEENSRLS 390
E ++ +K + L+QE +++RR +E E Q R+ Q E +L+ E
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR 1071
Query: 391 GRAT-------------EKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQV 437
R E+EQ+ E E R + QER+ R+ + LQ + E L
Sbjct: 1072 RRQELERQYRKEEELQQEEEQLLREEPEKRRR-----QERERQCREEEELQQEEEQL--- 1123
Query: 438 LKHMREVAQRRQQLEVEH--------EQARLSLREKQEEVRRLQQAQAEAQREHEGAVQL 489
+RE ++R++ E+E +Q L ++ E RR Q+ + + + E E +
Sbjct: 1124 ---LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE 1180
Query: 490 LESTLDSMQARVRELEEQCRSQTE 513
+ + + R +E E Q R + E
Sbjct: 1181 EQLLREEQEKRRQERERQYREEEE 1204
Score = 59.7 bits (143), Expect = 3e-08
Identities = 94/442 (21%), Positives = 187/442 (42%), Gaps = 44/442 (9%)
Query: 102 EDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRR 161
E+EE++ + L R EL R + R+ + +EE Q+LR+ +++ R
Sbjct: 1112 EEEELQQEEEQLLREEREKRRRQELER---QYREEEEVQQEEEQLLREEPEKRRRQELER 1168
Query: 162 LKRKNAELAVIAKRL--EERARKLQETNLRVVSAPLPRPGTSLELCRKALARQRARDLSE 219
R+ EL ++L EE+ ++ QE R E ++ +QR RD +
Sbjct: 1169 QYREEEELQQEEEQLLREEQEKRRQERE---------RQYREEEELQRQKRKQRYRDEDQ 1219
Query: 220 TASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRL---- 275
+ + + +E ++ G+E Q+ + D R+SQ+++ L
Sbjct: 1220 RSDLKWQWEPE-----KENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274
Query: 276 QRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQ 335
Q + + +R +P L+ A + ++ + ++ E E+++
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLEREEQKEA-----KRRDRKSQEEKQLLREEREEKR 1329
Query: 336 RVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATE 395
R Q+ + + ++ + + E++ ++Q R + + + Q + + +EE RL + E
Sbjct: 1330 RRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERE 1389
Query: 396 KEQVEWENAELRGQLLG--VTQERDSALRKSQGLQSKLE-------SLEQVLKHMREVAQ 446
++ ++ E +LR Q + Q+RD R+ + S+ E +QV + RE
Sbjct: 1390 RKFLK-EEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE--- 1445
Query: 447 RRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLD-SMQARVRELE 505
R+ LE E + + R+ +EE + LQ+ + + E + LE Q R R+
Sbjct: 1446 -RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFR 1504
Query: 506 EQ-CRSQTEQFSLLAQELQAFR 526
EQ RSQ + L +E Q R
Sbjct: 1505 EQELRSQEPERKFLEEEQQLHR 1526
Score = 59.7 bits (143), Expect = 3e-08
Identities = 93/449 (20%), Positives = 178/449 (39%), Gaps = 75/449 (16%)
Query: 98 CQRPEDEEVEAFLKAKLNMSFGDRPNLE-LLRALGELRQRCAILKEENQMLRKSSFPETE 156
C+ E+E+ ++L DR + + L LGE ++R + R FPE E
Sbjct: 1242 CKGRENEQFRQLEDSQLR----DRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEE 1297
Query: 157 E-------KVRRLKRKNAELAVIAKRLEERARKLQETNLRV----------VSAPLPRPG 199
+ + +R RK+ E + + E R+ QET+ + PL R
Sbjct: 1298 QLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQE 1357
Query: 200 TSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVR 259
+ + L Q E L +++++ +RE + L+ L +E Q L +
Sbjct: 1358 RDRKFREEELRHQ------EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLR-Q 1410
Query: 260 DFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQE 319
D DR RE ++++ R +R R + + + QE
Sbjct: 1411 DRDRKFREEEQQLSRQERDRKFREEEQ---------------------------QVRRQE 1443
Query: 320 DADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQ-------RRCEELELQL 372
E + + QQL E +K ++ E L QE ++Q R+ E E QL
Sbjct: 1444 R---------ERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQL 1494
Query: 373 RQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLE 432
R+ + + +E L + E++ +E E R Q + + LR+ + Q + +
Sbjct: 1495 RRQERDRKFREQE---LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQ 1551
Query: 433 SLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLES 492
++ + ++ Q R++ ++ ++ R ++++VRR +Q + + E + Q +
Sbjct: 1552 DRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQ 1611
Query: 493 TLDSMQARVRELEEQCRSQTEQFSLLAQE 521
L + R +EQ + E+ L QE
Sbjct: 1612 QLRQERDRKFREDEQLLQEREEQQLHRQE 1640
Score = 59.3 bits (142), Expect = 3e-08
Identities = 106/432 (24%), Positives = 164/432 (37%), Gaps = 54/432 (12%)
Query: 140 LKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPG 199
L+ E + R E E + +RLKR+ E KR EE R QE + +
Sbjct: 425 LRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER 484
Query: 200 TSLELCRKALAR---------QRARDLSETASALLAKDKQIAALQRECRELQARLTLVGK 250
L + R Q R+ E L + ++ LQ+ R Q +L +
Sbjct: 485 RERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQ-QLRREQE 543
Query: 251 EGPQWLHVRDFDRLLRESQREVLRLQRQIA------LRNQRETLPLPPSWPPGPALQARA 304
E + L R+ ++ L + +RE RL+R+ L+ + E L+ R
Sbjct: 544 ERREQLLKREEEKRLEQERREQ-RLKREQEERRDQLLKREEERRQQRLKREQEERLEQRL 602
Query: 305 GAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCE-SLEQEARKKQR 363
E QE+ + EPE+E+R Q L+SE ++R++ + EQ+ R++QR
Sbjct: 603 KREEV----ERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR 658
Query: 364 -----RCEELELQLRQAQNENAR---LVEENSRLSGRATEKEQVEWE-----NAELRGQL 410
E LE +L++ E R L EE + + +W+ A+ R
Sbjct: 659 LKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK 718
Query: 411 LGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHE-------------- 456
+ + R+ Q + K E L+ E RQQ E E
Sbjct: 719 VYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE 778
Query: 457 --QARLSLREKQEEVRRLQ-QAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTE 513
+ RLS R E R Q +A+ QRE + E Q R RE E Q + E
Sbjct: 779 RGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEE 838
Query: 514 QFSL--LAQELQ 523
Q AQ+LQ
Sbjct: 839 QLQRRERAQQLQ 850
Score = 58.2 bits (139), Expect = 8e-08
Identities = 112/442 (25%), Positives = 179/442 (40%), Gaps = 69/442 (15%)
Query: 132 ELRQ-RCAILKEENQML--RKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNL 188
+LRQ R +EE Q+L R+ +E+ R+ + +L R +ER RK +E L
Sbjct: 1454 QLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQL-----RRQERDRKFREQEL 1508
Query: 189 RVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLV 248
R S E RK L ++ + L +++Q+ +R + Q R
Sbjct: 1509 R-----------SQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKF 1557
Query: 249 GKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPA 308
+E Q R+ +L R+ + RL+ Q R ++E + L+ + G
Sbjct: 1558 -REEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE----QQLRRQEGQQQ 1612
Query: 309 PGAPGEATPQEDADNLP---------------VILGEPE--KEQRVQQLESELSKKRKKC 351
+ +ED L + EP+ +++R QQL + +K ++
Sbjct: 1613 LRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREE 1672
Query: 352 ESLEQEARKKQ-------RRCEELELQLRQAQNENARLVEENS----RLSGRATEKEQV- 399
E L QE ++Q R+ E E QLR+ + E L EE L + E+EQ+
Sbjct: 1673 EQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLR 1732
Query: 400 -EWENAELRGQ-----LLGVTQ---ERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQ 450
E E +LR Q +L Q ER+ + Q K EQ L+ RE Q R Q
Sbjct: 1733 QETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQ-LRQEREEQQLRSQ 1791
Query: 451 LEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRE--LEEQC 508
+ LR+++EE + Q + R E +QL E Q R R+ EEQ
Sbjct: 1792 ESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQF 1851
Query: 509 ----RSQTEQFSLLAQELQAFR 526
+S+ E+ L +E Q R
Sbjct: 1852 ATQEKSRREEQELWQEEEQKRR 1873
Score = 57.4 bits (137), Expect = 1e-07
Identities = 96/396 (24%), Positives = 170/396 (42%), Gaps = 58/396 (14%)
Query: 140 LKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPG 199
L++E Q+L+ E EE+++R +R+ +R E+ + +E L+ L R
Sbjct: 899 LRKEQQLLQ-----EEEEELQREEREKR------RRQEQERQYREEEQLQQEEEQLLREE 947
Query: 200 TSLELCRKALARQRARD--LSETASALLAKDKQIAALQ------RECRELQARLTLVGKE 251
R+ RQ +D L + LL ++ + Q RE ELQ + +E
Sbjct: 948 REKRR-RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLRE 1006
Query: 252 GPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGA 311
+ ++++R R+ ++ L+ + + LR +RE L Q R
Sbjct: 1007 EREKRRRQEWERQYRK--KDELQQEEEQLLREEREKRRLQER-----ERQYRE------- 1052
Query: 312 PGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKK--QRRCEELE 369
E Q++ + L LGE + +R Q+LE + K+ + + EQ R++ +RR +E E
Sbjct: 1053 --EEELQQEEEQL---LGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERE 1107
Query: 370 LQLRQA----QNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQ 425
Q R+ Q E L EE + + E++ E E V QE + LR+
Sbjct: 1108 RQCREEEELQQEEEQLLREEREKRRRQELERQYREEEE---------VQQEEEQLLREEP 1158
Query: 426 GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQ--EEVRRLQQAQAEAQREH 483
+ + E LE+ + E+ Q +QL E ++ R RE+Q EE +Q + + R+
Sbjct: 1159 EKRRRQE-LERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDE 1217
Query: 484 EGAVQLLESTLDSMQARVRELEEQCRS-QTEQFSLL 518
+ L + VR+ + C+ + EQF L
Sbjct: 1218 DQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQL 1253
Score = 52.4 bits (124), Expect = 4e-06
Identities = 91/415 (21%), Positives = 169/415 (40%), Gaps = 43/415 (10%)
Query: 132 ELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRL--EERARKLQETNLR 189
+ R+ + +EE Q+L + +++ R RK EL ++L EE ++ ++ R
Sbjct: 1049 QYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERER 1108
Query: 190 VVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVG 249
+L R+ ++R ++L ++ L RE E + R L
Sbjct: 1109 QCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELER 1168
Query: 250 KEGPQWLHVRDFDRLLRESQR--------------EVLRLQRQIALRNQRETLPLPPSWP 295
+ + ++ ++LLRE Q E+ R +R+ R++ + L W
Sbjct: 1169 QYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWE 1228
Query: 296 PGPALQARAGAP-APGAPGEATPQ-EDADNLPVILGEPEKEQRVQQLESELSKKRKKCES 353
P R G E Q ED+ L + + +Q +Q L E ++ +
Sbjct: 1229 PEKENAVRDNKVYCKGRENEQFRQLEDSQ-----LRDRQSQQDLQHLLGEQQERDR---- 1279
Query: 354 LEQEARKKQRRCEEL--ELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLL 411
EQE R+ Q+R E QL + + + A+ + S+ EK+ + E E R +
Sbjct: 1280 -EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQ-----EEKQLLREEREEKRRR-- 1331
Query: 412 GVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRR 471
QE D R+ + L + E EQ L+ + R++ E+ H++ E+++ +RR
Sbjct: 1332 ---QETDRKFREEEQLLQERE--EQPLRRQERDRKFREE-ELRHQEQGRKFLEEEQRLRR 1385
Query: 472 LQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR 526
++ + + E + Q E L + R EEQ S+ E+ +E Q R
Sbjct: 1386 QERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVR 1440
Score = 47.4 bits (111), Expect = 1e-04
Identities = 111/491 (22%), Positives = 191/491 (38%), Gaps = 108/491 (21%)
Query: 99 QRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPET--- 155
Q E+EEV+ + L R EL R + R+ + +EE Q+LR+
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQELER---QYREEEELQQEEEQLLREEQEKRRQER 1195
Query: 156 ------EEKVRRLKRKNA-----------------------ELAVIAK-RLEERARKLQE 185
EE+++R KRK + V K R E+ R+L++
Sbjct: 1196 ERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLED 1255
Query: 186 TNLRVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARL 245
+ LR S + + L Q+ RD + +D+ ++ RE Q
Sbjct: 1256 SQLR--------DRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEA 1307
Query: 246 TLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAG 305
++ ++ +LLRE + E R Q + E L LQ R
Sbjct: 1308 KRRDRKS------QEEKQLLREEREEKRRRQETDRKFREEEQL-----------LQEREE 1350
Query: 306 APAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRC 365
P + +E+ L E+ ++ + E L ++ ++ + L++E +Q RC
Sbjct: 1351 QPLRRQERDRKFREEE------LRHQEQGRKFLEEEQRLRRQERERKFLKEE---QQLRC 1401
Query: 366 EELELQLRQAQNENARLVEENSRLSGRAT------EKEQVEWENAELR--GQLLGVTQER 417
+E E QLRQ ++ R EE +LS + E++QV + E + + + QER
Sbjct: 1402 QEREQQLRQDRDRKFR--EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQER 1459
Query: 418 DSALRKSQGLQSK---------------LESLEQVLKHMREVAQRRQQLEVEHEQARLSL 462
R+ + L + LE +Q+ + R+ R Q+L + E R L
Sbjct: 1460 HRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ-EPERKFL 1518
Query: 463 RE-----KQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSL 517
E +Q+ R+ Q + + +R+ G + + RE EEQ R + E+ L
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERG-----QQRRQDRDRKFRE-EEQLRQEREEQQL 1572
Query: 518 LAQEL-QAFRL 527
QE + FRL
Sbjct: 1573 SRQERDRKFRL 1583
Score = 43.9 bits (102), Expect = 0.001
Identities = 101/422 (23%), Positives = 168/422 (39%), Gaps = 80/422 (18%)
Query: 132 ELRQRCAILKEENQMLRKS---SFPETEEKVRRLK--RKNAELAVIAKRLEERARKLQET 186
+LRQ +EE Q+ R+ F E+KVRR + RK E +R E + + QE
Sbjct: 1562 QLRQE----REEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQER 1617
Query: 187 NLRV-VSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARL 245
+ + L + +L R+ +R R E L ++++ R+ +
Sbjct: 1618 DRKFREDEQLLQEREEQQLHRQ----ERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEE 1673
Query: 246 TLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETL---PLPPSWPPGPALQA 302
L+ + Q L ++ DR RE ++++ R +R+ + + L L + L+
Sbjct: 1674 QLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLR- 1732
Query: 303 RAGAPAPGAPGEATPQEDA---DNLPVILGE----PEKEQRVQQLESELSKKRKKCESLE 355
+ T QE + IL E PE+E++ Q E +K ++ E L
Sbjct: 1733 -----------QETEQEQLRRQERYRKILEEEQLRPEREEQ-QLRRQERDRKFREEEQLR 1780
Query: 356 QEARKKQRRCEELELQLRQAQNENARLVEENSRLSGR----ATEKEQVEWENAELRGQLL 411
QE ++Q R +E + + R+ + E+ R R E+EQ++ E E R
Sbjct: 1781 QEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQR---- 1836
Query: 412 GVTQERDSALRKSQ--GLQSKLESLEQVL-------------KHMREVAQRRQQLEVEHE 456
+ QERD R + Q K EQ L + +RE RRQQ
Sbjct: 1837 -LRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQ------ 1889
Query: 457 QARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLE---STLDSMQARVRELEEQCRSQTE 513
+EE R Q + ++Q E +G +LLE S+ R L E + Q
Sbjct: 1890 ---------KEEQRHRQVGEIKSQ-EGKGHGRLLEPGTHQFASVPVRSSPLYEYIQEQRS 1939
Query: 514 QF 515
Q+
Sbjct: 1940 QY 1941
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 80.1 bits (196), Expect = 2e-14
Identities = 132/514 (25%), Positives = 216/514 (42%), Gaps = 65/514 (12%)
Query: 102 EDEEVEAFLKA-KLNMSFGDRPNLELLRALGELRQRCAILKEENQM----LRKSSFPETE 156
E EE+ A L+A K +S E + AL + R +L E + L++S
Sbjct: 1023 EQEELLARLEAEKEELS-------EEIAALQQERDEGLLLAESEKQQALSLKESEKTALS 1075
Query: 157 EKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQRARD 216
EK+ + A +++ +R + A+ QE + V+A L L R+ A A++
Sbjct: 1076 EKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNA-LTSELRDLRAQREEAAAAHAQE 1134
Query: 217 LSETASALLAKDKQIAALQRECRELQARLTLV--GKEGPQWLHVRDFDRLLRESQREVLR 274
+ KQ + RE EL+ +L L+ ++G + + + R LRESQ E
Sbjct: 1135 VRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLR-RELLEAQRKLRESQ-EGRE 1192
Query: 275 LQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAP-GEATPQEDADNLPVILGEPEK 333
+QRQ A +R G + R A + +++ + + L +K
Sbjct: 1193 VQRQEAGELRRSL---------GEGAKEREALRRSNEELRSAVKKAESERISLKLANEDK 1243
Query: 334 EQRVQQLES-------ELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEEN 386
EQ++ LE E + R + +E+ + +R +EL Q++ +EN RL E
Sbjct: 1244 EQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGREL 1303
Query: 387 SRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQ 446
+ L GR E+ E E+ R + LG+ Q R +G ++ LE + Q L +VAQ
Sbjct: 1304 AELQGRLALGERAEKES---RRETLGLRQ------RLLKG-EASLEVMRQEL----QVAQ 1349
Query: 447 RR-QQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELE 505
R+ Q+ E E L EE R ++ Q + R E ++L + ++ + +R
Sbjct: 1350 RKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLE--LKLEAARAEAAELGLRLSA 1407
Query: 506 EQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALDCG-SLGDCPPPPCCCSIPQPCRGSG 564
+ R+Q + L E+Q R L L SAL G LG P P P+P GS
Sbjct: 1408 AEGRAQGLEAELARVEVQR-RAAEAQLGGLRSALRRGLGLGRAPSP-----APRPVPGSP 1461
Query: 565 PKDLDLPPGSPG-------RCTPKSSEPAPATLT 591
+D G C+P S P+P T
Sbjct: 1462 ARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPAT 1495
Score = 66.6 bits (161), Expect = 2e-10
Identities = 130/536 (24%), Positives = 221/536 (41%), Gaps = 70/536 (13%)
Query: 28 TPGRGGEPSSA-APSIADTPPAAL----------QLQELRSEESSKPKGDGSSRPVGGTD 76
+PGRG P +P+ +D+ AL Q+Q++R + G+ R
Sbjct: 500 SPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDS 559
Query: 77 PEGAEACLPSLGQQASSSGPACQRPED--EEVEAFLKAKLNMSFGDRPNLELLRALGELR 134
A L + + A Q ED EV+ A +S R L +L +
Sbjct: 560 ESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLS---REKSNLAHSLQVAQ 616
Query: 135 QRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARK-LQETNLRVVSA 193
Q+ L++E + L+ + +E++RR + + E A + R R+ L+ ++ ++
Sbjct: 617 QQAEELRQEREKLQAA-----QEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQL 671
Query: 194 PLPRPGTSLELC--RKALARQRA-RDLSETASALLAKDKQIAALQRECRELQARLT-LVG 249
R + EL R+AL+R RD+ + A +A+ A R EL+ +T L
Sbjct: 672 EGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRV--ELELSMTKLRA 729
Query: 250 KEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAP 309
+E + L ++ L L R +A + ++ ALQ R
Sbjct: 730 EEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKS-----------ALQGRQRQ--- 775
Query: 310 GAPGEAT-PQEDADNLPVILGEPE------------KEQRVQQLESELSKKRKKCESLEQ 356
A EAT +E+ + L + E E EQ + LE +L R + L++
Sbjct: 776 -AEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQE 834
Query: 357 EARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQE 416
+ + R+ E +L QA+ E R VE R A EKE + E+A L QL+ +E
Sbjct: 835 QLAQLSRQLSGREQELEQARREAQRQVEALERA---AREKEALAKEHAGLAVQLVAAERE 891
Query: 417 RDSALRKSQGLQSKLESLE----QVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRL 472
+ ++ L+ + E+LE +V + + ++ RR+QLE E + L+ E+ L
Sbjct: 892 GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 951
Query: 473 QQ----AQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQA 524
+Q Q +A + E Q L QA +R EQ + E L +E +A
Sbjct: 952 RQQIIATQEKASLDKELMAQKLVQAEREAQASLR---EQRAAHEEDLQRLQREKEA 1004
Score = 64.3 bits (155), Expect = 1e-09
Identities = 149/581 (25%), Positives = 233/581 (40%), Gaps = 99/581 (17%)
Query: 8 PRPGDP-------GAMEPWALPTWHSWTPGRGGEPSSAAPSIA----DTPPAALQ----- 51
P PG P G+ E P+ +PG +P S P+ + D P A++
Sbjct: 1456 PVPGSPARDAPAEGSGEGLNSPSTLECSPG--SQPPSPGPATSPASPDLDPEAVRGALRE 1513
Query: 52 -LQELRSEESSKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFL 110
LQELRS + + D + + AE + + A+S Q+ E EA
Sbjct: 1514 FLQELRSAQRER---DELRTQTSALNRQLAE--MEAERDSATSRARQLQKAVAESEEARR 1568
Query: 111 KAKLNMSFGDRPNLELLR--ALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAE 168
+S G + L L R+R A L + + R S TE ++R + K ++
Sbjct: 1569 SVDGRLS-GVQAELALQEESVRRSERERRATLDQVATLER--SLQATESELRASQEKISK 1625
Query: 169 LAVIAKRLEERARKLQE----TNLRVVSAPLPRPGTSLELCRKALA----RQRARDLSET 220
+ +LE R+L+E + R V L R EL R L +A+ L +
Sbjct: 1626 MKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDR 1685
Query: 221 ASALLAK--DKQIAA--LQRECRELQARLTLVGK-EGPQWLHVRDFDRLLRESQREV--- 272
+L + D ++ A LQ L L V + EG VR L +S +
Sbjct: 1686 VDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNST 1745
Query: 273 ----LRLQRQI-ALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVI 327
L LQ+ + A + R+ L +AR + + G + E AD +
Sbjct: 1746 RDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVAD---LE 1802
Query: 328 LGEPEKEQRVQQLESELSKKRK-------KCESLEQEARKKQRRCEELELQLRQAQNENA 380
L E E ++QQL L ++++ + L+ E R Q R L+ L Q + E
Sbjct: 1803 LQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKR 1862
Query: 381 RLVE-----ENSRLSGRAT----EKEQVEW---------ENAELRGQLLGVTQERDSALR 422
+ E R++ R T E+E++ E L L G E A R
Sbjct: 1863 EVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQR 1922
Query: 423 KSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQRE 482
+ Q L++++ LEQ + QLEV+ +Q +L L Q+EV RL+ AQA+ +R
Sbjct: 1923 QIQQLEAQVVVLEQ--------SHSPAQLEVDAQQQQLEL---QQEVERLRSAQAQTER- 1970
Query: 483 HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQ 523
LE+ + + RVR LEEQ + Q L QEL+
Sbjct: 1971 ------TLEARERAHRQRVRGLEEQVSTLKGQ---LQQELR 2002
Score = 54.3 bits (129), Expect = 1e-06
Identities = 104/429 (24%), Positives = 176/429 (41%), Gaps = 42/429 (9%)
Query: 128 RALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQ--E 185
R L +L + ++L +E +R++ T ++ L+ + AE+A + E +L+
Sbjct: 666 RQLEQLEGKRSVLAKELVEVREALSRATLQR-DMLQAEKAEVAEALTKAEAGRVELELSM 724
Query: 186 TNLRVVSAPLPRPGTSLELCRKALARQR------ARDLSETASALLAKDKQIAALQRECR 239
T LR A L + L ++LA+ + L E SAL + +Q R
Sbjct: 725 TKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAR 784
Query: 240 ELQARLTLV---------GKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPL 290
E Q RL + G EG L V + + E Q LR +R L+ Q L
Sbjct: 785 EEQERLEELRLEQEVARQGLEGS--LRVAEQAQEALEQQLPTLRHERS-QLQEQLAQLSR 841
Query: 291 PPSWPPGPALQARAGAPAP-------GAPGEATPQEDADNLPVILGEPEKEQRVQQLESE 343
S QAR A EA +E A L V L E+E R L E
Sbjct: 842 QLSGREQELEQARREAQRQVEALERAAREKEALAKEHA-GLAVQLVAAEREGRT--LSEE 898
Query: 344 LSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQ---VE 400
++ R + E+LE + QR+ +LE + Q + E L+ L+G Q
Sbjct: 899 ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIAT 958
Query: 401 WENAELRGQLLG---VTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQ 457
E A L +L+ V ER++ + + E L++ L+ +E A R E+E E+
Sbjct: 959 QEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQR-LQREKEAAWR----ELEAER 1013
Query: 458 ARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSL 517
A+L + ++E+ L + +AE + E L + + + E ++ + + +
Sbjct: 1014 AQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTA 1073
Query: 518 LAQELQAFR 526
L+++L R
Sbjct: 1074 LSEKLMGTR 1082
Score = 50.1 bits (118), Expect = 2e-05
Identities = 98/417 (23%), Positives = 154/417 (36%), Gaps = 65/417 (15%)
Query: 125 ELLRALGELRQRCAILKEENQMLRKS-----SFPETEEKVRRLKRKNAELAVIAKRLEER 179
+LL+ GEL + ++E L S E + + L + E + K L E+
Sbjct: 320 DLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREK 379
Query: 180 ARKLQETNLRVVSAPLPRPGTSLELCRKALARQRA------RDLSETASALLAKDKQIAA 233
Q+ + A L T L L K L +Q +DL+E AL
Sbjct: 380 DLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEAL--------- 430
Query: 234 LQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPS 293
E LQ + L ++G E ++ LR Q L + + L S
Sbjct: 431 ---ESLRLQEQAALETEDG--------------EGLQQTLRDLAQAVLSDSESGVQLSGS 473
Query: 294 WPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCES 353
A + G G+ TP P P + + ++ S
Sbjct: 474 ERTADA----SNGSLRGLSGQRTPS------PPRRSSPGRGRSPRRGPSPACSDSSTLAL 523
Query: 354 LEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGV 413
+ K+Q + +++ + +Q+ L +LS +E+ +E + LR + G
Sbjct: 524 IHSALHKRQLQVQDMRGRYEASQDLLGTL---RKQLSDSESERRALEEQLQRLRDKTDGA 580
Query: 414 TQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQ 473
Q + A R+ Q L+S E L + ++ Q QQ E Q R L+ QEE+RR +
Sbjct: 581 MQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQR 640
Query: 474 QAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQF----SLLAQELQAFR 526
+ E E AVQ ARVR E+ Q EQ S+LA+EL R
Sbjct: 641 D---RLEEEQEDAVQ--------DGARVRRELERSHRQLEQLEGKRSVLAKELVEVR 686
Score = 48.9 bits (115), Expect = 5e-05
Identities = 86/391 (21%), Positives = 156/391 (39%), Gaps = 69/391 (17%)
Query: 177 EERARKLQETNLRVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQR 236
E R+ + + LR ++ L R +E R + A RAR L K +A +
Sbjct: 1517 ELRSAQRERDELRTQTSALNRQLAEMEAERDS-ATSRARQLQ----------KAVAESEE 1565
Query: 237 ECRELQARLTLVGKE-GPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWP 295
R + RL+ V E Q VR +R R + +V L+R +
Sbjct: 1566 ARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESE---------- 1615
Query: 296 PGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEK-----EQRVQQLESELSKKRKK 350
L+A + E + D L +L E E + + LE EL + R
Sbjct: 1616 ----LRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLG 1671
Query: 351 CESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQL 410
E +A+ Q R + L+ Q+ ++ + L RL+G + E+ E LR ++
Sbjct: 1672 LSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESE---GALRDKV 1728
Query: 411 LGVTQ-------------ERDSALRKS--------QGLQSKLESLEQVLKHMREVAQRRQ 449
G+T+ +++ L+K+ Q LQ +L++ Q L R+ +
Sbjct: 1729 RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLG 1788
Query: 450 Q-----------LEVEHEQARLSLREKQEEVRRLQQAQAEAQ---REHEGAVQLLESTLD 495
+ LE++ +A L++ +E +R+ Q+ +A A ++ + +LL+ L
Sbjct: 1789 EQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLG 1848
Query: 496 SMQARVRELEEQCRSQTEQFSLLAQELQAFR 526
S+Q + +LE + R L ++ A R
Sbjct: 1849 SLQRALAQLEAEKREVERSALRLEKDRVALR 1879
Score = 41.6 bits (96), Expect = 0.007
Identities = 64/267 (23%), Positives = 112/267 (41%), Gaps = 39/267 (14%)
Query: 225 LAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRES------QREVLRLQRQ 278
LA+D QI +L RE+ R L E P L + LL Q+E+ R++
Sbjct: 38 LAQDAQITSLPALIREIVTR-NLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDL 96
Query: 279 IAL-RNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRV 337
+A R +R+ L + + A+ R PGE QE P L E R
Sbjct: 97 LAQSRAERDELAIKYN-----AVSERLEQALRLEPGELETQE-----PRGLVRQSVELR- 145
Query: 338 QQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKE 397
+QL+ E + R+K ++ ++ +++ + + L+ ++ Q + R E +L R+ E E
Sbjct: 146 RQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKK---RCSELEQQLLERSGELE 202
Query: 398 QVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQ 457
Q + E SQ L+S L LE+ + +AQ L + +Q
Sbjct: 203 QQRLRDTE-----------------HSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQ 245
Query: 458 ARLSLREKQEEVRRLQQAQAEAQREHE 484
A + + E++R++ ++E E
Sbjct: 246 AGSANQALSEDIRKVTNDWTRCRKELE 272
Score = 38.1 bits (87), Expect = 0.080
Identities = 40/136 (29%), Positives = 57/136 (41%), Gaps = 18/136 (13%)
Query: 372 LRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKL 431
L Q EN L +E SR+ + E EL + V++ + ALR G +L
Sbjct: 76 LLSLQEENQLLQQELSRVEDLLAQSRA---ERDELAIKYNAVSERLEQALRLEPG---EL 129
Query: 432 ESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLE 491
E+ E + V RRQ L+E+Q RR QA E Q+ VQ L+
Sbjct: 130 ETQEPRGLVRQSVELRRQ------------LQEEQASYRRKLQAYQEGQQRQAQLVQRLQ 177
Query: 492 STLDSMQARVRELEEQ 507
+ + R ELE+Q
Sbjct: 178 GKILQYKKRCSELEQQ 193
Score = 37.7 bits (86), Expect = 0.11
Identities = 56/237 (23%), Positives = 106/237 (44%), Gaps = 48/237 (20%)
Query: 329 GEPEKEQRVQQLESELSKKRKKCESLEQEARKK-----QRRCEELE---------LQLRQ 374
G+ + Q VQ+L+ ++ + +K+C LEQ+ ++ Q+R + E ++L +
Sbjct: 165 GQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEE 224
Query: 375 AQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVT----------QERDSALRKS 424
Q +A L + N+ L + +Q N L + VT + R++A R+
Sbjct: 225 EQQRSASLAQVNAML---REQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRRE 281
Query: 425 Q--------GLQSKLESL-EQVLKHMREVAQ-----RRQQLEVEHEQARLSLREKQEEV- 469
+ S+L L QV+ R V++ R L++ E AR S ++ +
Sbjct: 282 EESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLG 341
Query: 470 ----RRLQQAQAEAQREHEGAVQL-LESTLDSMQARVREL-EEQCRSQTEQFSLLAQ 520
RL +++AEA E + +Q LE L R ++L ++Q +S ++ L A+
Sbjct: 342 LSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSAR 398
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 75.1 bits (183), Expect = 6e-13
Identities = 111/454 (24%), Positives = 184/454 (40%), Gaps = 33/454 (7%)
Query: 99 QRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAIL-----KEENQMLRKSSFP 153
QR + EE LKA + + LEL LG +R + E + R+
Sbjct: 1919 QRRQVEEEILALKASFEKAAAGKAELEL--ELGRIRSNAEDTLRSKEQAELEAARQRQLA 1976
Query: 154 ETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQR 213
EE+ RR + + ++ A+ R RK + + A + E + ARQ
Sbjct: 1977 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036
Query: 214 ARDLSETASALLAKDKQIA-ALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREV 272
L A++K A A+Q++ +ELQ L Q + R E E
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2096
Query: 273 LRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPE 332
R+Q + R + QA+A A A A + + + + E
Sbjct: 2097 -RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2155
Query: 333 KEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGR 392
++ Q ++E+ K +K E ++ + ++ L LQL + ++ L EE RL
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2215
Query: 393 ATE----KEQVEWENAELRGQL--LGVTQERDSALRKSQGLQSKLES---LEQVLKHMRE 443
ATE + QVE E +R Q+ L + R A ++ L+ K + L++ + M++
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2275
Query: 444 VAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ-REHEGAVQ----------LLES 492
VA+ +L V ++A LR+ EE Q+A AE +E AVQ LL+
Sbjct: 2276 VAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334
Query: 493 TLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR 526
+ Q + R L+E +Q LA+E Q F+
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQ---LAEETQGFQ 2365
Score = 73.2 bits (178), Expect = 2e-12
Identities = 109/464 (23%), Positives = 198/464 (42%), Gaps = 61/464 (13%)
Query: 90 QASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRK 149
+A ++ A QR + EE ++ ++ L L+A E R IL++++ R
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQME-------ELSKLKARIEAENRALILRDKDNTQR- 2264
Query: 150 SSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKAL 209
E EK++++ + A L+V A+ R R+L E +L A + L K
Sbjct: 2265 -FLQEEAEKMKQVAEEAARLSVAAQEAA-RLRQLAEEDLAQQRALAEKM-----LKEKMQ 2317
Query: 210 ARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQ 269
A Q A L A LL + K++A Q + R LQ + ++ + + F R L E++
Sbjct: 2318 AVQEATRLKAEAE-LLQQQKELA--QEQARRLQEDKEQMAQQLAE--ETQGFQRTL-EAE 2371
Query: 270 REVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILG 329
R QRQ+ + + E L L A +RA A A +EDA
Sbjct: 2372 R-----QRQLEMSAEAERLKLRV------AEMSRAQARA---------EEDAQRFRK--Q 2409
Query: 330 EPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRL 389
E +++ + E +K ++LE + ++ E L + + + E +L +E L
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 390 SGRATEKEQVEWENAELRGQLL--GVTQERDSALRKSQGLQSKLESLEQVL--------- 438
++ E + V+ E Q L E+DS L++ + ++ + LEQ+
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2529
Query: 439 ------KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLES 492
+ +++ Q RQ+L E+AR E +E VRR Q+ + +++ +LL
Sbjct: 2530 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2589
Query: 493 TLDSMQARVRELEEQCRSQ-TEQFSLLAQELQAFRLHPGPLDLL 535
++ +++ LEEQ R+ + A ++ A + P D L
Sbjct: 2590 ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2633
Score = 67.8 bits (164), Expect = 9e-11
Identities = 104/429 (24%), Positives = 173/429 (40%), Gaps = 61/429 (14%)
Query: 129 ALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNL 188
A G +QR A E +++R + E E+ R+L + ELA + + +K QE
Sbjct: 1701 AEGTAQQRLAA---EQELIRLRAETEQGEQQRQLLEE--ELARLQREAAAATQKRQELEA 1755
Query: 189 RVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLV 248
+ R + L KA A + +R SE + L + A RE E ARL +
Sbjct: 1756 ELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRAL 1809
Query: 249 GKEGPQWLHVRDFD---------RLLRESQREV-----LRLQRQIALRNQRETLPLPPSW 294
+E + + + D R+L E + L+ + +IAL+ +
Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869
Query: 295 PPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESL 354
A Q R E Q AD E+R+ QL + ++ + L
Sbjct: 1870 AEDEAFQRRRLE-------EQAAQHKADI----------EERLAQLRKASDSELERQKGL 1912
Query: 355 EQEARKKQRRCEE----LELQLRQAQNENARLVEENSRLSGRATE----KEQVEWENAEL 406
++ +++R+ EE L+ +A A L E R+ A + KEQ E E A
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 407 RGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQAR-LSLREK 465
R QL +E + +Q L + E+ + + + ++L+ + E+AR L R +
Sbjct: 1973 R-QL--AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2029
Query: 466 QEEVRRLQQAQAEAQRE-------HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLL 518
QE R+LQ AQ AQ+ H AVQ E L + + + +Q R + E
Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089
Query: 519 AQELQAFRL 527
A+E + R+
Sbjct: 2090 AEEAEEARV 2098
Score = 60.5 bits (145), Expect = 2e-08
Identities = 94/367 (25%), Positives = 150/367 (40%), Gaps = 68/367 (18%)
Query: 174 KRLEERARKLQETNLRVVSAPLPRPGTSLELCR--KALARQRARDLSETASALLAKDKQI 231
+RL E+ R + L V A L + E KA A + A++L + + + ++
Sbjct: 1348 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1407
Query: 232 AA-LQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQI-ALRNQRETLP 289
A Q++ R +Q L + + + + R ++R LR++ +I +R Q E
Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKA--RQAEAAERSRLRIEEEIRVVRLQLEATE 1465
Query: 290 LPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRK 349
G RA A A + QE+A+ L + ++ QR +Q E EL+ R
Sbjct: 1466 RQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQV--QDESQRKRQAEVELAS-RV 1521
Query: 350 KCESLEQEARKKQR----------RCEELELQLRQAQNENARLVEENSRLSGRATEKEQV 399
K E+ + AR+KQR + EE E +LRQA+ E AR V+ + R+ E E
Sbjct: 1522 KAEA--EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE-- 1577
Query: 400 EWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQAR 459
LQSK S A++ QLE ++
Sbjct: 1578 ---------------------------LQSKRASF----------AEKTAQLERSLQEEH 1600
Query: 460 LSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRE---LEEQCRSQTEQFS 516
+++ + +EE R Q QAEA+R E A E L+ Q + E L Q +Q S
Sbjct: 1601 VAVAQLREEAERRAQQQAEAERAREEA----ERELERWQLKANEALRLRLQAEEVAQQKS 1656
Query: 517 LLAQELQ 523
L E +
Sbjct: 1657 LAQAEAE 1663
Score = 57.8 bits (138), Expect = 1e-07
Identities = 95/391 (24%), Positives = 160/391 (40%), Gaps = 44/391 (11%)
Query: 132 ELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVV 191
E QR A + E Q R S +T + R L+ ++ +A + + E RA++ E
Sbjct: 1568 ETAQRSA--EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625
Query: 192 SAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKE 251
A L+ R +A ++++ S A+ A Q+E E +AR GK
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE----AEKQKEEAEREARRR--GKA 1679
Query: 252 GPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGA 311
Q + R+ E QR++ Q L ++E + L A
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR----------------AETE 1723
Query: 312 PGEATPQEDADNLPVILGEPEKE-QRVQQLESELSKKRKKCESL---EQEARKKQRRCEE 367
GE Q + L + E Q+ Q+LE+EL+K R + E L + A ++ R E
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783
Query: 368 LELQLRQAQNENAR-LVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQG 426
Q +A+ R L EE +RL A E A+ + QL E D+A ++++
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALA--------EEAKRQRQLA----EEDAARQRAEA 1831
Query: 427 ---LQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREH 483
L KL ++ + + E ++ E E+E+ R ++ + RRL++ A+ + +
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891
Query: 484 EGAVQLLESTLDSMQARVRELEEQCRSQTEQ 514
E + L DS R + L E Q Q
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQ 1922
Score = 51.6 bits (122), Expect = 7e-06
Identities = 103/485 (21%), Positives = 194/485 (40%), Gaps = 70/485 (14%)
Query: 76 DPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQ 135
D E A C + +Q + EVE K +S E + AL E
Sbjct: 1012 DKEPARECAQRIAEQQKAQA---------EVEGLGKGVARLS----AEAEKVLALPEPSP 1058
Query: 136 RCAILKEENQM-LRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAP 194
L+ E ++ L K + + K K L + + E + E L+ A
Sbjct: 1059 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA- 1117
Query: 195 LPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQ 254
+P LE + +L + RA+ ++ + +D ++ Q LQ R E +
Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRD-ELRGAQEVGERLQQRHGERDVEVER 1176
Query: 255 WLH-----VRDFDRLLRES---QREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGA 306
W + + +L ++ QRE+ +L RQ LR RE+ P G LQ
Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQ--LRYYRESAD-----PLGAWLQ----- 1224
Query: 307 PAPGAPGEATPQEDADNLPVILGEPEKEQ--RVQQLESELSKKRKKCESLEQEARKKQRR 364
QE +P+ + +EQ + Q L E+ + +K E ++ A++
Sbjct: 1225 ------DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1278
Query: 365 CEELELQL----------------RQAQNENARLVEENSRLSGRATEKEQVEWENAELRG 408
++ ELQL + Q+ + +++E L +E + + +
Sbjct: 1279 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1338
Query: 409 QLLGVTQERDSALRKSQGLQ-SKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREK-Q 466
+ L +E + + + + +L +E L+ R++A+ Q + + E+ L+++ Q
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 467 EEVRRLQQAQAEAQRE----HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQEL 522
EEV R ++A +AQ++ E QL +S+ +QA+ R+ E RS+ + +E+
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR----IEEEI 1454
Query: 523 QAFRL 527
+ RL
Sbjct: 1455 RVVRL 1459
Score = 45.1 bits (105), Expect = 7e-04
Identities = 120/502 (23%), Positives = 203/502 (40%), Gaps = 86/502 (17%)
Query: 34 EPSSAAPSIADTPPAAL-QLQELRSEESSK-PKGDGSSRPVGGTDPEGAEACLPSLGQQA 91
EPS AAP++ L +L+++RS + K S + GT +GAE L + +Q
Sbjct: 1055 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQL 1112
Query: 92 SSSGPA-CQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKS 150
+ PE E +A LK + +P + LR ELR +E + L++
Sbjct: 1113 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR--DELRGA----QEVGERLQQR 1166
Query: 151 SFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALA 210
E + +V R + + A+L LE L +T++R L + G L R++
Sbjct: 1167 H-GERDVEVERWRERVAQL------LERWQAVLAQTDVR--QRELEQLGRQLRYYRESAD 1217
Query: 211 R-----QRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLL 265
Q AR E A+ D Q A++ + R+ QA L + + G + V + R
Sbjct: 1218 PLGAWLQDARRRQEQIQAMPLADSQ--AVREQLRQEQALLEEIERHGEK---VEECQRFA 1272
Query: 266 RESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLP 325
++ + + Q+ + L P P + ++G+ E+ QE D
Sbjct: 1273 KQYINAIKDYELQLVTYKAQ----LEPVASPAKKPKVQSGS-------ESVIQEYVD--- 1318
Query: 326 VILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEE 385
+ E Q +S+ ++ E E+E +Q+R EE E R A+ E A L ++
Sbjct: 1319 LRTHYSELTTLTSQYIKFISETLRRME--EEERLAEQQRAEERE---RLAEVE-AALEKQ 1372
Query: 386 NSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVA 445
A K Q E E EL+ + M+E
Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQ-------------------------------QRMQEEV 1401
Query: 446 QRRQQLEVEHEQARLSLREKQEEVRRLQQ-AQAEAQREHEGAVQLLESTLDSMQARVREL 504
RR++ V+ +Q + S+ QEE+++L+Q ++AE Q + A S L ++ +R +
Sbjct: 1402 VRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVV 1457
Query: 505 EEQCRSQTEQFSLLAQELQAFR 526
Q + Q ELQA R
Sbjct: 1458 RLQLEATERQRGGAEGELQALR 1479
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 75.1 bits (183), Expect = 6e-13
Identities = 111/454 (24%), Positives = 184/454 (40%), Gaps = 33/454 (7%)
Query: 99 QRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAIL-----KEENQMLRKSSFP 153
QR + EE LKA + + LEL LG +R + E + R+
Sbjct: 1923 QRRQVEEEILALKASFEKAAAGKAELEL--ELGRIRSNAEDTLRSKEQAELEAARQRQLA 1980
Query: 154 ETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQR 213
EE+ RR + + ++ A+ R RK + + A + E + ARQ
Sbjct: 1981 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2040
Query: 214 ARDLSETASALLAKDKQIA-ALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREV 272
L A++K A A+Q++ +ELQ L Q + R E E
Sbjct: 2041 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2100
Query: 273 LRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPE 332
R+Q + R + QA+A A A A + + + + E
Sbjct: 2101 -RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2159
Query: 333 KEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGR 392
++ Q ++E+ K +K E ++ + ++ L LQL + ++ L EE RL
Sbjct: 2160 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2219
Query: 393 ATE----KEQVEWENAELRGQL--LGVTQERDSALRKSQGLQSKLES---LEQVLKHMRE 443
ATE + QVE E +R Q+ L + R A ++ L+ K + L++ + M++
Sbjct: 2220 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2279
Query: 444 VAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ-REHEGAVQ----------LLES 492
VA+ +L V ++A LR+ EE Q+A AE +E AVQ LL+
Sbjct: 2280 VAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2338
Query: 493 TLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR 526
+ Q + R L+E +Q LA+E Q F+
Sbjct: 2339 QKELAQEQARRLQEDKEQMAQQ---LAEETQGFQ 2369
Score = 73.2 bits (178), Expect = 2e-12
Identities = 109/464 (23%), Positives = 198/464 (42%), Gaps = 61/464 (13%)
Query: 90 QASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRK 149
+A ++ A QR + EE ++ ++ L L+A E R IL++++ R
Sbjct: 2217 KAEATEAARQRSQVEEELFSVRVQME-------ELSKLKARIEAENRALILRDKDNTQR- 2268
Query: 150 SSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKAL 209
E EK++++ + A L+V A+ R R+L E +L A + L K
Sbjct: 2269 -FLQEEAEKMKQVAEEAARLSVAAQEAA-RLRQLAEEDLAQQRALAEKM-----LKEKMQ 2321
Query: 210 ARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQ 269
A Q A L A LL + K++A Q + R LQ + ++ + + F R L E++
Sbjct: 2322 AVQEATRLKAEAE-LLQQQKELA--QEQARRLQEDKEQMAQQLAE--ETQGFQRTL-EAE 2375
Query: 270 REVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILG 329
R QRQ+ + + E L L A +RA A A +EDA
Sbjct: 2376 R-----QRQLEMSAEAERLKLRV------AEMSRAQARA---------EEDAQRFRK--Q 2413
Query: 330 EPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRL 389
E +++ + E +K ++LE + ++ E L + + + E +L +E L
Sbjct: 2414 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2473
Query: 390 SGRATEKEQVEWENAELRGQLL--GVTQERDSALRKSQGLQSKLESLEQVL--------- 438
++ E + V+ E Q L E+DS L++ + ++ + LEQ+
Sbjct: 2474 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2533
Query: 439 ------KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLES 492
+ +++ Q RQ+L E+AR E +E VRR Q+ + +++ +LL
Sbjct: 2534 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2593
Query: 493 TLDSMQARVRELEEQCRSQ-TEQFSLLAQELQAFRLHPGPLDLL 535
++ +++ LEEQ R+ + A ++ A + P D L
Sbjct: 2594 ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2637
Score = 67.8 bits (164), Expect = 9e-11
Identities = 104/429 (24%), Positives = 173/429 (40%), Gaps = 61/429 (14%)
Query: 129 ALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNL 188
A G +QR A E +++R + E E+ R+L + ELA + + +K QE
Sbjct: 1705 AEGTAQQRLAA---EQELIRLRAETEQGEQQRQLLEE--ELARLQREAAAATQKRQELEA 1759
Query: 189 RVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLV 248
+ R + L KA A + +R SE + L + A RE E ARL +
Sbjct: 1760 ELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRAL 1813
Query: 249 GKEGPQWLHVRDFD---------RLLRESQREV-----LRLQRQIALRNQRETLPLPPSW 294
+E + + + D R+L E + L+ + +IAL+ +
Sbjct: 1814 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1873
Query: 295 PPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESL 354
A Q R E Q AD E+R+ QL + ++ + L
Sbjct: 1874 AEDEAFQRRRLE-------EQAAQHKADI----------EERLAQLRKASDSELERQKGL 1916
Query: 355 EQEARKKQRRCEE----LELQLRQAQNENARLVEENSRLSGRATE----KEQVEWENAEL 406
++ +++R+ EE L+ +A A L E R+ A + KEQ E E A
Sbjct: 1917 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1976
Query: 407 RGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQAR-LSLREK 465
R QL +E + +Q L + E+ + + + ++L+ + E+AR L R +
Sbjct: 1977 R-QL--AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2033
Query: 466 QEEVRRLQQAQAEAQRE-------HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLL 518
QE R+LQ AQ AQ+ H AVQ E L + + + +Q R + E
Sbjct: 2034 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2093
Query: 519 AQELQAFRL 527
A+E + R+
Sbjct: 2094 AEEAEEARV 2102
Score = 60.5 bits (145), Expect = 2e-08
Identities = 94/367 (25%), Positives = 150/367 (40%), Gaps = 68/367 (18%)
Query: 174 KRLEERARKLQETNLRVVSAPLPRPGTSLELCR--KALARQRARDLSETASALLAKDKQI 231
+RL E+ R + L V A L + E KA A + A++L + + + ++
Sbjct: 1352 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1411
Query: 232 AA-LQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQI-ALRNQRETLP 289
A Q++ R +Q L + + + + R ++R LR++ +I +R Q E
Sbjct: 1412 AVDAQQQKRSIQEELQQLRQSSEAEIQAKA--RQAEAAERSRLRIEEEIRVVRLQLEATE 1469
Query: 290 LPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRK 349
G RA A A + QE+A+ L + ++ QR +Q E EL+ R
Sbjct: 1470 RQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQV--QDESQRKRQAEVELAS-RV 1525
Query: 350 KCESLEQEARKKQR----------RCEELELQLRQAQNENARLVEENSRLSGRATEKEQV 399
K E+ + AR+KQR + EE E +LRQA+ E AR V+ + R+ E E
Sbjct: 1526 KAEA--EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE-- 1581
Query: 400 EWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQAR 459
LQSK S A++ QLE ++
Sbjct: 1582 ---------------------------LQSKRASF----------AEKTAQLERSLQEEH 1604
Query: 460 LSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRE---LEEQCRSQTEQFS 516
+++ + +EE R Q QAEA+R E A E L+ Q + E L Q +Q S
Sbjct: 1605 VAVAQLREEAERRAQQQAEAERAREEA----ERELERWQLKANEALRLRLQAEEVAQQKS 1660
Query: 517 LLAQELQ 523
L E +
Sbjct: 1661 LAQAEAE 1667
Score = 57.8 bits (138), Expect = 1e-07
Identities = 95/391 (24%), Positives = 160/391 (40%), Gaps = 44/391 (11%)
Query: 132 ELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVV 191
E QR A + E Q R S +T + R L+ ++ +A + + E RA++ E
Sbjct: 1572 ETAQRSA--EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1629
Query: 192 SAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKE 251
A L+ R +A ++++ S A+ A Q+E E +AR GK
Sbjct: 1630 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE----AEKQKEEAEREARRR--GKA 1683
Query: 252 GPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGA 311
Q + R+ E QR++ Q L ++E + L A
Sbjct: 1684 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR----------------AETE 1727
Query: 312 PGEATPQEDADNLPVILGEPEKE-QRVQQLESELSKKRKKCESL---EQEARKKQRRCEE 367
GE Q + L + E Q+ Q+LE+EL+K R + E L + A ++ R E
Sbjct: 1728 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1787
Query: 368 LELQLRQAQNENAR-LVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQG 426
Q +A+ R L EE +RL A E A+ + QL E D+A ++++
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARLRALA--------EEAKRQRQLA----EEDAARQRAEA 1835
Query: 427 ---LQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREH 483
L KL ++ + + E ++ E E+E+ R ++ + RRL++ A+ + +
Sbjct: 1836 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1895
Query: 484 EGAVQLLESTLDSMQARVRELEEQCRSQTEQ 514
E + L DS R + L E Q Q
Sbjct: 1896 EERLAQLRKASDSELERQKGLVEDTLRQRRQ 1926
Score = 51.6 bits (122), Expect = 7e-06
Identities = 103/485 (21%), Positives = 194/485 (40%), Gaps = 70/485 (14%)
Query: 76 DPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQ 135
D E A C + +Q + EVE K +S E + AL E
Sbjct: 1016 DKEPARECAQRIAEQQKAQA---------EVEGLGKGVARLS----AEAEKVLALPEPSP 1062
Query: 136 RCAILKEENQM-LRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAP 194
L+ E ++ L K + + K K L + + E + E L+ A
Sbjct: 1063 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA- 1121
Query: 195 LPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQ 254
+P LE + +L + RA+ ++ + +D ++ Q LQ R E +
Sbjct: 1122 VPATLPELEATKASLKKLRAQAEAQQPTFDALRD-ELRGAQEVGERLQQRHGERDVEVER 1180
Query: 255 WLH-----VRDFDRLLRES---QREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGA 306
W + + +L ++ QRE+ +L RQ LR RE+ P G LQ
Sbjct: 1181 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQ--LRYYRESAD-----PLGAWLQ----- 1228
Query: 307 PAPGAPGEATPQEDADNLPVILGEPEKEQ--RVQQLESELSKKRKKCESLEQEARKKQRR 364
QE +P+ + +EQ + Q L E+ + +K E ++ A++
Sbjct: 1229 ------DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1282
Query: 365 CEELELQL----------------RQAQNENARLVEENSRLSGRATEKEQVEWENAELRG 408
++ ELQL + Q+ + +++E L +E + + +
Sbjct: 1283 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1342
Query: 409 QLLGVTQERDSALRKSQGLQ-SKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREK-Q 466
+ L +E + + + + +L +E L+ R++A+ Q + + E+ L+++ Q
Sbjct: 1343 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1402
Query: 467 EEVRRLQQAQAEAQRE----HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQEL 522
EEV R ++A +AQ++ E QL +S+ +QA+ R+ E RS+ + +E+
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR----IEEEI 1458
Query: 523 QAFRL 527
+ RL
Sbjct: 1459 RVVRL 1463
Score = 45.1 bits (105), Expect = 7e-04
Identities = 120/502 (23%), Positives = 203/502 (40%), Gaps = 86/502 (17%)
Query: 34 EPSSAAPSIADTPPAAL-QLQELRSEESSK-PKGDGSSRPVGGTDPEGAEACLPSLGQQA 91
EPS AAP++ L +L+++RS + K S + GT +GAE L + +Q
Sbjct: 1059 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQL 1116
Query: 92 SSSGPA-CQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKS 150
+ PE E +A LK + +P + LR ELR +E + L++
Sbjct: 1117 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR--DELRGA----QEVGERLQQR 1170
Query: 151 SFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALA 210
E + +V R + + A+L LE L +T++R L + G L R++
Sbjct: 1171 H-GERDVEVERWRERVAQL------LERWQAVLAQTDVR--QRELEQLGRQLRYYRESAD 1221
Query: 211 R-----QRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLL 265
Q AR E A+ D Q A++ + R+ QA L + + G + V + R
Sbjct: 1222 PLGAWLQDARRRQEQIQAMPLADSQ--AVREQLRQEQALLEEIERHGEK---VEECQRFA 1276
Query: 266 RESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLP 325
++ + + Q+ + L P P + ++G+ E+ QE D
Sbjct: 1277 KQYINAIKDYELQLVTYKAQ----LEPVASPAKKPKVQSGS-------ESVIQEYVD--- 1322
Query: 326 VILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEE 385
+ E Q +S+ ++ E E+E +Q+R EE E R A+ E A L ++
Sbjct: 1323 LRTHYSELTTLTSQYIKFISETLRRME--EEERLAEQQRAEERE---RLAEVE-AALEKQ 1376
Query: 386 NSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVA 445
A K Q E E EL+ + M+E
Sbjct: 1377 RQLAEAHAQAKAQAEREAKELQ-------------------------------QRMQEEV 1405
Query: 446 QRRQQLEVEHEQARLSLREKQEEVRRLQQ-AQAEAQREHEGAVQLLESTLDSMQARVREL 504
RR++ V+ +Q + S+ QEE+++L+Q ++AE Q + A S L ++ +R +
Sbjct: 1406 VRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVV 1461
Query: 505 EEQCRSQTEQFSLLAQELQAFR 526
Q + Q ELQA R
Sbjct: 1462 RLQLEATERQRGGAEGELQALR 1483
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 75.1 bits (183), Expect = 6e-13
Identities = 111/454 (24%), Positives = 184/454 (40%), Gaps = 33/454 (7%)
Query: 99 QRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAIL-----KEENQMLRKSSFP 153
QR + EE LKA + + LEL LG +R + E + R+
Sbjct: 1919 QRRQVEEEILALKASFEKAAAGKAELEL--ELGRIRSNAEDTLRSKEQAELEAARQRQLA 1976
Query: 154 ETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQR 213
EE+ RR + + ++ A+ R RK + + A + E + ARQ
Sbjct: 1977 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036
Query: 214 ARDLSETASALLAKDKQIA-ALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREV 272
L A++K A A+Q++ +ELQ L Q + R E E
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2096
Query: 273 LRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPE 332
R+Q + R + QA+A A A A + + + + E
Sbjct: 2097 -RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2155
Query: 333 KEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGR 392
++ Q ++E+ K +K E ++ + ++ L LQL + ++ L EE RL
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2215
Query: 393 ATE----KEQVEWENAELRGQL--LGVTQERDSALRKSQGLQSKLES---LEQVLKHMRE 443
ATE + QVE E +R Q+ L + R A ++ L+ K + L++ + M++
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2275
Query: 444 VAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ-REHEGAVQ----------LLES 492
VA+ +L V ++A LR+ EE Q+A AE +E AVQ LL+
Sbjct: 2276 VAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334
Query: 493 TLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR 526
+ Q + R L+E +Q LA+E Q F+
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQ---LAEETQGFQ 2365
Score = 73.2 bits (178), Expect = 2e-12
Identities = 109/464 (23%), Positives = 198/464 (42%), Gaps = 61/464 (13%)
Query: 90 QASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRK 149
+A ++ A QR + EE ++ ++ L L+A E R IL++++ R
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQME-------ELSKLKARIEAENRALILRDKDNTQR- 2264
Query: 150 SSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKAL 209
E EK++++ + A L+V A+ R R+L E +L A + L K
Sbjct: 2265 -FLQEEAEKMKQVAEEAARLSVAAQEAA-RLRQLAEEDLAQQRALAEKM-----LKEKMQ 2317
Query: 210 ARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQ 269
A Q A L A LL + K++A Q + R LQ + ++ + + F R L E++
Sbjct: 2318 AVQEATRLKAEAE-LLQQQKELA--QEQARRLQEDKEQMAQQLAE--ETQGFQRTL-EAE 2371
Query: 270 REVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILG 329
R QRQ+ + + E L L A +RA A A +EDA
Sbjct: 2372 R-----QRQLEMSAEAERLKLRV------AEMSRAQARA---------EEDAQRFRK--Q 2409
Query: 330 EPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRL 389
E +++ + E +K ++LE + ++ E L + + + E +L +E L
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 390 SGRATEKEQVEWENAELRGQLL--GVTQERDSALRKSQGLQSKLESLEQVL--------- 438
++ E + V+ E Q L E+DS L++ + ++ + LEQ+
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2529
Query: 439 ------KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLES 492
+ +++ Q RQ+L E+AR E +E VRR Q+ + +++ +LL
Sbjct: 2530 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2589
Query: 493 TLDSMQARVRELEEQCRSQ-TEQFSLLAQELQAFRLHPGPLDLL 535
++ +++ LEEQ R+ + A ++ A + P D L
Sbjct: 2590 ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2633
Score = 67.8 bits (164), Expect = 9e-11
Identities = 104/429 (24%), Positives = 173/429 (40%), Gaps = 61/429 (14%)
Query: 129 ALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNL 188
A G +QR A E +++R + E E+ R+L + ELA + + +K QE
Sbjct: 1701 AEGTAQQRLAA---EQELIRLRAETEQGEQQRQLLEE--ELARLQREAAAATQKRQELEA 1755
Query: 189 RVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLV 248
+ R + L KA A + +R SE + L + A RE E ARL +
Sbjct: 1756 ELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRAL 1809
Query: 249 GKEGPQWLHVRDFD---------RLLRESQREV-----LRLQRQIALRNQRETLPLPPSW 294
+E + + + D R+L E + L+ + +IAL+ +
Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869
Query: 295 PPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESL 354
A Q R E Q AD E+R+ QL + ++ + L
Sbjct: 1870 AEDEAFQRRRLE-------EQAAQHKADI----------EERLAQLRKASDSELERQKGL 1912
Query: 355 EQEARKKQRRCEE----LELQLRQAQNENARLVEENSRLSGRATE----KEQVEWENAEL 406
++ +++R+ EE L+ +A A L E R+ A + KEQ E E A
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 407 RGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQAR-LSLREK 465
R QL +E + +Q L + E+ + + + ++L+ + E+AR L R +
Sbjct: 1973 R-QL--AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2029
Query: 466 QEEVRRLQQAQAEAQRE-------HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLL 518
QE R+LQ AQ AQ+ H AVQ E L + + + +Q R + E
Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089
Query: 519 AQELQAFRL 527
A+E + R+
Sbjct: 2090 AEEAEEARV 2098
Score = 60.5 bits (145), Expect = 2e-08
Identities = 94/367 (25%), Positives = 150/367 (40%), Gaps = 68/367 (18%)
Query: 174 KRLEERARKLQETNLRVVSAPLPRPGTSLELCR--KALARQRARDLSETASALLAKDKQI 231
+RL E+ R + L V A L + E KA A + A++L + + + ++
Sbjct: 1348 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1407
Query: 232 AA-LQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQI-ALRNQRETLP 289
A Q++ R +Q L + + + + R ++R LR++ +I +R Q E
Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKA--RQAEAAERSRLRIEEEIRVVRLQLEATE 1465
Query: 290 LPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRK 349
G RA A A + QE+A+ L + ++ QR +Q E EL+ R
Sbjct: 1466 RQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQV--QDESQRKRQAEVELAS-RV 1521
Query: 350 KCESLEQEARKKQR----------RCEELELQLRQAQNENARLVEENSRLSGRATEKEQV 399
K E+ + AR+KQR + EE E +LRQA+ E AR V+ + R+ E E
Sbjct: 1522 KAEA--EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE-- 1577
Query: 400 EWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQAR 459
LQSK S A++ QLE ++
Sbjct: 1578 ---------------------------LQSKRASF----------AEKTAQLERSLQEEH 1600
Query: 460 LSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRE---LEEQCRSQTEQFS 516
+++ + +EE R Q QAEA+R E A E L+ Q + E L Q +Q S
Sbjct: 1601 VAVAQLREEAERRAQQQAEAERAREEA----ERELERWQLKANEALRLRLQAEEVAQQKS 1656
Query: 517 LLAQELQ 523
L E +
Sbjct: 1657 LAQAEAE 1663
Score = 57.8 bits (138), Expect = 1e-07
Identities = 95/391 (24%), Positives = 160/391 (40%), Gaps = 44/391 (11%)
Query: 132 ELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVV 191
E QR A + E Q R S +T + R L+ ++ +A + + E RA++ E
Sbjct: 1568 ETAQRSA--EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625
Query: 192 SAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKE 251
A L+ R +A ++++ S A+ A Q+E E +AR GK
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE----AEKQKEEAEREARRR--GKA 1679
Query: 252 GPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGA 311
Q + R+ E QR++ Q L ++E + L A
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR----------------AETE 1723
Query: 312 PGEATPQEDADNLPVILGEPEKE-QRVQQLESELSKKRKKCESL---EQEARKKQRRCEE 367
GE Q + L + E Q+ Q+LE+EL+K R + E L + A ++ R E
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783
Query: 368 LELQLRQAQNENAR-LVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQG 426
Q +A+ R L EE +RL A E A+ + QL E D+A ++++
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALA--------EEAKRQRQLA----EEDAARQRAEA 1831
Query: 427 ---LQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREH 483
L KL ++ + + E ++ E E+E+ R ++ + RRL++ A+ + +
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891
Query: 484 EGAVQLLESTLDSMQARVRELEEQCRSQTEQ 514
E + L DS R + L E Q Q
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQ 1922
Score = 51.6 bits (122), Expect = 7e-06
Identities = 103/485 (21%), Positives = 194/485 (40%), Gaps = 70/485 (14%)
Query: 76 DPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQ 135
D E A C + +Q + EVE K +S E + AL E
Sbjct: 1012 DKEPARECAQRIAEQQKAQA---------EVEGLGKGVARLS----AEAEKVLALPEPSP 1058
Query: 136 RCAILKEENQM-LRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAP 194
L+ E ++ L K + + K K L + + E + E L+ A
Sbjct: 1059 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA- 1117
Query: 195 LPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQ 254
+P LE + +L + RA+ ++ + +D ++ Q LQ R E +
Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRD-ELRGAQEVGERLQQRHGERDVEVER 1176
Query: 255 WLH-----VRDFDRLLRES---QREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGA 306
W + + +L ++ QRE+ +L RQ LR RE+ P G LQ
Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQ--LRYYRESAD-----PLGAWLQ----- 1224
Query: 307 PAPGAPGEATPQEDADNLPVILGEPEKEQ--RVQQLESELSKKRKKCESLEQEARKKQRR 364
QE +P+ + +EQ + Q L E+ + +K E ++ A++
Sbjct: 1225 ------DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1278
Query: 365 CEELELQL----------------RQAQNENARLVEENSRLSGRATEKEQVEWENAELRG 408
++ ELQL + Q+ + +++E L +E + + +
Sbjct: 1279 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1338
Query: 409 QLLGVTQERDSALRKSQGLQ-SKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREK-Q 466
+ L +E + + + + +L +E L+ R++A+ Q + + E+ L+++ Q
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 467 EEVRRLQQAQAEAQRE----HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQEL 522
EEV R ++A +AQ++ E QL +S+ +QA+ R+ E RS+ + +E+
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR----IEEEI 1454
Query: 523 QAFRL 527
+ RL
Sbjct: 1455 RVVRL 1459
Score = 45.1 bits (105), Expect = 7e-04
Identities = 120/502 (23%), Positives = 203/502 (40%), Gaps = 86/502 (17%)
Query: 34 EPSSAAPSIADTPPAAL-QLQELRSEESSK-PKGDGSSRPVGGTDPEGAEACLPSLGQQA 91
EPS AAP++ L +L+++RS + K S + GT +GAE L + +Q
Sbjct: 1055 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQL 1112
Query: 92 SSSGPA-CQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKS 150
+ PE E +A LK + +P + LR ELR +E + L++
Sbjct: 1113 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR--DELRGA----QEVGERLQQR 1166
Query: 151 SFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALA 210
E + +V R + + A+L LE L +T++R L + G L R++
Sbjct: 1167 H-GERDVEVERWRERVAQL------LERWQAVLAQTDVR--QRELEQLGRQLRYYRESAD 1217
Query: 211 R-----QRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLL 265
Q AR E A+ D Q A++ + R+ QA L + + G + V + R
Sbjct: 1218 PLGAWLQDARRRQEQIQAMPLADSQ--AVREQLRQEQALLEEIERHGEK---VEECQRFA 1272
Query: 266 RESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLP 325
++ + + Q+ + L P P + ++G+ E+ QE D
Sbjct: 1273 KQYINAIKDYELQLVTYKAQ----LEPVASPAKKPKVQSGS-------ESVIQEYVD--- 1318
Query: 326 VILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEE 385
+ E Q +S+ ++ E E+E +Q+R EE E R A+ E A L ++
Sbjct: 1319 LRTHYSELTTLTSQYIKFISETLRRME--EEERLAEQQRAEERE---RLAEVE-AALEKQ 1372
Query: 386 NSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVA 445
A K Q E E EL+ + M+E
Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQ-------------------------------QRMQEEV 1401
Query: 446 QRRQQLEVEHEQARLSLREKQEEVRRLQQ-AQAEAQREHEGAVQLLESTLDSMQARVREL 504
RR++ V+ +Q + S+ QEE+++L+Q ++AE Q + A S L ++ +R +
Sbjct: 1402 VRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVV 1457
Query: 505 EEQCRSQTEQFSLLAQELQAFR 526
Q + Q ELQA R
Sbjct: 1458 RLQLEATERQRGGAEGELQALR 1479
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 75.1 bits (183), Expect = 6e-13
Identities = 111/454 (24%), Positives = 184/454 (40%), Gaps = 33/454 (7%)
Query: 99 QRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAIL-----KEENQMLRKSSFP 153
QR + EE LKA + + LEL LG +R + E + R+
Sbjct: 1887 QRRQVEEEILALKASFEKAAAGKAELEL--ELGRIRSNAEDTLRSKEQAELEAARQRQLA 1944
Query: 154 ETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQR 213
EE+ RR + + ++ A+ R RK + + A + E + ARQ
Sbjct: 1945 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2004
Query: 214 ARDLSETASALLAKDKQIA-ALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREV 272
L A++K A A+Q++ +ELQ L Q + R E E
Sbjct: 2005 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2064
Query: 273 LRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPE 332
R+Q + R + QA+A A A A + + + + E
Sbjct: 2065 -RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2123
Query: 333 KEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGR 392
++ Q ++E+ K +K E ++ + ++ L LQL + ++ L EE RL
Sbjct: 2124 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2183
Query: 393 ATE----KEQVEWENAELRGQL--LGVTQERDSALRKSQGLQSKLES---LEQVLKHMRE 443
ATE + QVE E +R Q+ L + R A ++ L+ K + L++ + M++
Sbjct: 2184 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2243
Query: 444 VAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ-REHEGAVQ----------LLES 492
VA+ +L V ++A LR+ EE Q+A AE +E AVQ LL+
Sbjct: 2244 VAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2302
Query: 493 TLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR 526
+ Q + R L+E +Q LA+E Q F+
Sbjct: 2303 QKELAQEQARRLQEDKEQMAQQ---LAEETQGFQ 2333
Score = 73.2 bits (178), Expect = 2e-12
Identities = 109/464 (23%), Positives = 198/464 (42%), Gaps = 61/464 (13%)
Query: 90 QASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRK 149
+A ++ A QR + EE ++ ++ L L+A E R IL++++ R
Sbjct: 2181 KAEATEAARQRSQVEEELFSVRVQME-------ELSKLKARIEAENRALILRDKDNTQR- 2232
Query: 150 SSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKAL 209
E EK++++ + A L+V A+ R R+L E +L A + L K
Sbjct: 2233 -FLQEEAEKMKQVAEEAARLSVAAQEAA-RLRQLAEEDLAQQRALAEKM-----LKEKMQ 2285
Query: 210 ARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQ 269
A Q A L A LL + K++A Q + R LQ + ++ + + F R L E++
Sbjct: 2286 AVQEATRLKAEAE-LLQQQKELA--QEQARRLQEDKEQMAQQLAE--ETQGFQRTL-EAE 2339
Query: 270 REVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILG 329
R QRQ+ + + E L L A +RA A A +EDA
Sbjct: 2340 R-----QRQLEMSAEAERLKLRV------AEMSRAQARA---------EEDAQRFRK--Q 2377
Query: 330 EPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRL 389
E +++ + E +K ++LE + ++ E L + + + E +L +E L
Sbjct: 2378 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2437
Query: 390 SGRATEKEQVEWENAELRGQLL--GVTQERDSALRKSQGLQSKLESLEQVL--------- 438
++ E + V+ E Q L E+DS L++ + ++ + LEQ+
Sbjct: 2438 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2497
Query: 439 ------KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLES 492
+ +++ Q RQ+L E+AR E +E VRR Q+ + +++ +LL
Sbjct: 2498 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2557
Query: 493 TLDSMQARVRELEEQCRSQ-TEQFSLLAQELQAFRLHPGPLDLL 535
++ +++ LEEQ R+ + A ++ A + P D L
Sbjct: 2558 ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2601
Score = 67.8 bits (164), Expect = 9e-11
Identities = 104/429 (24%), Positives = 173/429 (40%), Gaps = 61/429 (14%)
Query: 129 ALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNL 188
A G +QR A E +++R + E E+ R+L + ELA + + +K QE
Sbjct: 1669 AEGTAQQRLAA---EQELIRLRAETEQGEQQRQLLEE--ELARLQREAAAATQKRQELEA 1723
Query: 189 RVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLV 248
+ R + L KA A + +R SE + L + A RE E ARL +
Sbjct: 1724 ELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRAL 1777
Query: 249 GKEGPQWLHVRDFD---------RLLRESQREV-----LRLQRQIALRNQRETLPLPPSW 294
+E + + + D R+L E + L+ + +IAL+ +
Sbjct: 1778 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1837
Query: 295 PPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESL 354
A Q R E Q AD E+R+ QL + ++ + L
Sbjct: 1838 AEDEAFQRRRLE-------EQAAQHKADI----------EERLAQLRKASDSELERQKGL 1880
Query: 355 EQEARKKQRRCEE----LELQLRQAQNENARLVEENSRLSGRATE----KEQVEWENAEL 406
++ +++R+ EE L+ +A A L E R+ A + KEQ E E A
Sbjct: 1881 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1940
Query: 407 RGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQAR-LSLREK 465
R QL +E + +Q L + E+ + + + ++L+ + E+AR L R +
Sbjct: 1941 R-QL--AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 1997
Query: 466 QEEVRRLQQAQAEAQRE-------HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLL 518
QE R+LQ AQ AQ+ H AVQ E L + + + +Q R + E
Sbjct: 1998 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2057
Query: 519 AQELQAFRL 527
A+E + R+
Sbjct: 2058 AEEAEEARV 2066
Score = 60.5 bits (145), Expect = 2e-08
Identities = 94/367 (25%), Positives = 150/367 (40%), Gaps = 68/367 (18%)
Query: 174 KRLEERARKLQETNLRVVSAPLPRPGTSLELCR--KALARQRARDLSETASALLAKDKQI 231
+RL E+ R + L V A L + E KA A + A++L + + + ++
Sbjct: 1316 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1375
Query: 232 AA-LQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQI-ALRNQRETLP 289
A Q++ R +Q L + + + + R ++R LR++ +I +R Q E
Sbjct: 1376 AVDAQQQKRSIQEELQQLRQSSEAEIQAKA--RQAEAAERSRLRIEEEIRVVRLQLEATE 1433
Query: 290 LPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRK 349
G RA A A + QE+A+ L + ++ QR +Q E EL+ R
Sbjct: 1434 RQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQV--QDESQRKRQAEVELAS-RV 1489
Query: 350 KCESLEQEARKKQR----------RCEELELQLRQAQNENARLVEENSRLSGRATEKEQV 399
K E+ + AR+KQR + EE E +LRQA+ E AR V+ + R+ E E
Sbjct: 1490 KAEA--EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE-- 1545
Query: 400 EWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQAR 459
LQSK S A++ QLE ++
Sbjct: 1546 ---------------------------LQSKRASF----------AEKTAQLERSLQEEH 1568
Query: 460 LSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRE---LEEQCRSQTEQFS 516
+++ + +EE R Q QAEA+R E A E L+ Q + E L Q +Q S
Sbjct: 1569 VAVAQLREEAERRAQQQAEAERAREEA----ERELERWQLKANEALRLRLQAEEVAQQKS 1624
Query: 517 LLAQELQ 523
L E +
Sbjct: 1625 LAQAEAE 1631
Score = 57.8 bits (138), Expect = 1e-07
Identities = 95/391 (24%), Positives = 160/391 (40%), Gaps = 44/391 (11%)
Query: 132 ELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVV 191
E QR A + E Q R S +T + R L+ ++ +A + + E RA++ E
Sbjct: 1536 ETAQRSA--EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1593
Query: 192 SAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKE 251
A L+ R +A ++++ S A+ A Q+E E +AR GK
Sbjct: 1594 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE----AEKQKEEAEREARRR--GKA 1647
Query: 252 GPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGA 311
Q + R+ E QR++ Q L ++E + L A
Sbjct: 1648 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR----------------AETE 1691
Query: 312 PGEATPQEDADNLPVILGEPEKE-QRVQQLESELSKKRKKCESL---EQEARKKQRRCEE 367
GE Q + L + E Q+ Q+LE+EL+K R + E L + A ++ R E
Sbjct: 1692 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1751
Query: 368 LELQLRQAQNENAR-LVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQG 426
Q +A+ R L EE +RL A E A+ + QL E D+A ++++
Sbjct: 1752 KSKQRLEAEAGRFRELAEEAARLRALA--------EEAKRQRQLA----EEDAARQRAEA 1799
Query: 427 ---LQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREH 483
L KL ++ + + E ++ E E+E+ R ++ + RRL++ A+ + +
Sbjct: 1800 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1859
Query: 484 EGAVQLLESTLDSMQARVRELEEQCRSQTEQ 514
E + L DS R + L E Q Q
Sbjct: 1860 EERLAQLRKASDSELERQKGLVEDTLRQRRQ 1890
Score = 51.6 bits (122), Expect = 7e-06
Identities = 103/485 (21%), Positives = 194/485 (40%), Gaps = 70/485 (14%)
Query: 76 DPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQ 135
D E A C + +Q + EVE K +S E + AL E
Sbjct: 980 DKEPARECAQRIAEQQKAQA---------EVEGLGKGVARLS----AEAEKVLALPEPSP 1026
Query: 136 RCAILKEENQM-LRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAP 194
L+ E ++ L K + + K K L + + E + E L+ A
Sbjct: 1027 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA- 1085
Query: 195 LPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQ 254
+P LE + +L + RA+ ++ + +D ++ Q LQ R E +
Sbjct: 1086 VPATLPELEATKASLKKLRAQAEAQQPTFDALRD-ELRGAQEVGERLQQRHGERDVEVER 1144
Query: 255 WLH-----VRDFDRLLRES---QREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGA 306
W + + +L ++ QRE+ +L RQ LR RE+ P G LQ
Sbjct: 1145 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQ--LRYYRESAD-----PLGAWLQ----- 1192
Query: 307 PAPGAPGEATPQEDADNLPVILGEPEKEQ--RVQQLESELSKKRKKCESLEQEARKKQRR 364
QE +P+ + +EQ + Q L E+ + +K E ++ A++
Sbjct: 1193 ------DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1246
Query: 365 CEELELQL----------------RQAQNENARLVEENSRLSGRATEKEQVEWENAELRG 408
++ ELQL + Q+ + +++E L +E + + +
Sbjct: 1247 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1306
Query: 409 QLLGVTQERDSALRKSQGLQ-SKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREK-Q 466
+ L +E + + + + +L +E L+ R++A+ Q + + E+ L+++ Q
Sbjct: 1307 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1366
Query: 467 EEVRRLQQAQAEAQRE----HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQEL 522
EEV R ++A +AQ++ E QL +S+ +QA+ R+ E RS+ + +E+
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR----IEEEI 1422
Query: 523 QAFRL 527
+ RL
Sbjct: 1423 RVVRL 1427
Score = 45.1 bits (105), Expect = 7e-04
Identities = 120/502 (23%), Positives = 203/502 (40%), Gaps = 86/502 (17%)
Query: 34 EPSSAAPSIADTPPAAL-QLQELRSEESSK-PKGDGSSRPVGGTDPEGAEACLPSLGQQA 91
EPS AAP++ L +L+++RS + K S + GT +GAE L + +Q
Sbjct: 1023 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQL 1080
Query: 92 SSSGPA-CQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKS 150
+ PE E +A LK + +P + LR ELR +E + L++
Sbjct: 1081 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR--DELRGA----QEVGERLQQR 1134
Query: 151 SFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALA 210
E + +V R + + A+L LE L +T++R L + G L R++
Sbjct: 1135 H-GERDVEVERWRERVAQL------LERWQAVLAQTDVR--QRELEQLGRQLRYYRESAD 1185
Query: 211 R-----QRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLL 265
Q AR E A+ D Q A++ + R+ QA L + + G + V + R
Sbjct: 1186 PLGAWLQDARRRQEQIQAMPLADSQ--AVREQLRQEQALLEEIERHGEK---VEECQRFA 1240
Query: 266 RESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLP 325
++ + + Q+ + L P P + ++G+ E+ QE D
Sbjct: 1241 KQYINAIKDYELQLVTYKAQ----LEPVASPAKKPKVQSGS-------ESVIQEYVD--- 1286
Query: 326 VILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEE 385
+ E Q +S+ ++ E E+E +Q+R EE E R A+ E A L ++
Sbjct: 1287 LRTHYSELTTLTSQYIKFISETLRRME--EEERLAEQQRAEERE---RLAEVE-AALEKQ 1340
Query: 386 NSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVA 445
A K Q E E EL+ + M+E
Sbjct: 1341 RQLAEAHAQAKAQAEREAKELQ-------------------------------QRMQEEV 1369
Query: 446 QRRQQLEVEHEQARLSLREKQEEVRRLQQ-AQAEAQREHEGAVQLLESTLDSMQARVREL 504
RR++ V+ +Q + S+ QEE+++L+Q ++AE Q + A S L ++ +R +
Sbjct: 1370 VRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVV 1425
Query: 505 EEQCRSQTEQFSLLAQELQAFR 526
Q + Q ELQA R
Sbjct: 1426 RLQLEATERQRGGAEGELQALR 1447
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 75.1 bits (183), Expect = 6e-13
Identities = 111/454 (24%), Positives = 184/454 (40%), Gaps = 33/454 (7%)
Query: 99 QRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAIL-----KEENQMLRKSSFP 153
QR + EE LKA + + LEL LG +R + E + R+
Sbjct: 2056 QRRQVEEEILALKASFEKAAAGKAELEL--ELGRIRSNAEDTLRSKEQAELEAARQRQLA 2113
Query: 154 ETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQR 213
EE+ RR + + ++ A+ R RK + + A + E + ARQ
Sbjct: 2114 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2173
Query: 214 ARDLSETASALLAKDKQIA-ALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREV 272
L A++K A A+Q++ +ELQ L Q + R E E
Sbjct: 2174 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2233
Query: 273 LRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPE 332
R+Q + R + QA+A A A A + + + + E
Sbjct: 2234 -RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2292
Query: 333 KEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGR 392
++ Q ++E+ K +K E ++ + ++ L LQL + ++ L EE RL
Sbjct: 2293 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2352
Query: 393 ATE----KEQVEWENAELRGQL--LGVTQERDSALRKSQGLQSKLES---LEQVLKHMRE 443
ATE + QVE E +R Q+ L + R A ++ L+ K + L++ + M++
Sbjct: 2353 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2412
Query: 444 VAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ-REHEGAVQ----------LLES 492
VA+ +L V ++A LR+ EE Q+A AE +E AVQ LL+
Sbjct: 2413 VAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2471
Query: 493 TLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR 526
+ Q + R L+E +Q LA+E Q F+
Sbjct: 2472 QKELAQEQARRLQEDKEQMAQQ---LAEETQGFQ 2502
Score = 73.2 bits (178), Expect = 2e-12
Identities = 109/464 (23%), Positives = 198/464 (42%), Gaps = 61/464 (13%)
Query: 90 QASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRK 149
+A ++ A QR + EE ++ ++ L L+A E R IL++++ R
Sbjct: 2350 KAEATEAARQRSQVEEELFSVRVQME-------ELSKLKARIEAENRALILRDKDNTQR- 2401
Query: 150 SSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKAL 209
E EK++++ + A L+V A+ R R+L E +L A + L K
Sbjct: 2402 -FLQEEAEKMKQVAEEAARLSVAAQEAA-RLRQLAEEDLAQQRALAEKM-----LKEKMQ 2454
Query: 210 ARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQ 269
A Q A L A LL + K++A Q + R LQ + ++ + + F R L E++
Sbjct: 2455 AVQEATRLKAEAE-LLQQQKELA--QEQARRLQEDKEQMAQQLAE--ETQGFQRTL-EAE 2508
Query: 270 REVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILG 329
R QRQ+ + + E L L A +RA A A +EDA
Sbjct: 2509 R-----QRQLEMSAEAERLKLRV------AEMSRAQARA---------EEDAQRFRK--Q 2546
Query: 330 EPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRL 389
E +++ + E +K ++LE + ++ E L + + + E +L +E L
Sbjct: 2547 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2606
Query: 390 SGRATEKEQVEWENAELRGQLL--GVTQERDSALRKSQGLQSKLESLEQVL--------- 438
++ E + V+ E Q L E+DS L++ + ++ + LEQ+
Sbjct: 2607 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2666
Query: 439 ------KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLES 492
+ +++ Q RQ+L E+AR E +E VRR Q+ + +++ +LL
Sbjct: 2667 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2726
Query: 493 TLDSMQARVRELEEQCRSQ-TEQFSLLAQELQAFRLHPGPLDLL 535
++ +++ LEEQ R+ + A ++ A + P D L
Sbjct: 2727 ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2770
Score = 67.8 bits (164), Expect = 9e-11
Identities = 104/429 (24%), Positives = 173/429 (40%), Gaps = 61/429 (14%)
Query: 129 ALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNL 188
A G +QR A E +++R + E E+ R+L + ELA + + +K QE
Sbjct: 1838 AEGTAQQRLAA---EQELIRLRAETEQGEQQRQLLEE--ELARLQREAAAATQKRQELEA 1892
Query: 189 RVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLV 248
+ R + L KA A + +R SE + L + A RE E ARL +
Sbjct: 1893 ELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRAL 1946
Query: 249 GKEGPQWLHVRDFD---------RLLRESQREV-----LRLQRQIALRNQRETLPLPPSW 294
+E + + + D R+L E + L+ + +IAL+ +
Sbjct: 1947 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 2006
Query: 295 PPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESL 354
A Q R E Q AD E+R+ QL + ++ + L
Sbjct: 2007 AEDEAFQRRRLE-------EQAAQHKADI----------EERLAQLRKASDSELERQKGL 2049
Query: 355 EQEARKKQRRCEE----LELQLRQAQNENARLVEENSRLSGRATE----KEQVEWENAEL 406
++ +++R+ EE L+ +A A L E R+ A + KEQ E E A
Sbjct: 2050 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 2109
Query: 407 RGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQAR-LSLREK 465
R QL +E + +Q L + E+ + + + ++L+ + E+AR L R +
Sbjct: 2110 R-QL--AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2166
Query: 466 QEEVRRLQQAQAEAQRE-------HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLL 518
QE R+LQ AQ AQ+ H AVQ E L + + + +Q R + E
Sbjct: 2167 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2226
Query: 519 AQELQAFRL 527
A+E + R+
Sbjct: 2227 AEEAEEARV 2235
Score = 60.5 bits (145), Expect = 2e-08
Identities = 94/367 (25%), Positives = 150/367 (40%), Gaps = 68/367 (18%)
Query: 174 KRLEERARKLQETNLRVVSAPLPRPGTSLELCR--KALARQRARDLSETASALLAKDKQI 231
+RL E+ R + L V A L + E KA A + A++L + + + ++
Sbjct: 1485 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1544
Query: 232 AA-LQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQI-ALRNQRETLP 289
A Q++ R +Q L + + + + R ++R LR++ +I +R Q E
Sbjct: 1545 AVDAQQQKRSIQEELQQLRQSSEAEIQAKA--RQAEAAERSRLRIEEEIRVVRLQLEATE 1602
Query: 290 LPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRK 349
G RA A A + QE+A+ L + ++ QR +Q E EL+ R
Sbjct: 1603 RQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQV--QDESQRKRQAEVELAS-RV 1658
Query: 350 KCESLEQEARKKQR----------RCEELELQLRQAQNENARLVEENSRLSGRATEKEQV 399
K E+ + AR+KQR + EE E +LRQA+ E AR V+ + R+ E E
Sbjct: 1659 KAEA--EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE-- 1714
Query: 400 EWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQAR 459
LQSK S A++ QLE ++
Sbjct: 1715 ---------------------------LQSKRASF----------AEKTAQLERSLQEEH 1737
Query: 460 LSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRE---LEEQCRSQTEQFS 516
+++ + +EE R Q QAEA+R E A E L+ Q + E L Q +Q S
Sbjct: 1738 VAVAQLREEAERRAQQQAEAERAREEA----ERELERWQLKANEALRLRLQAEEVAQQKS 1793
Query: 517 LLAQELQ 523
L E +
Sbjct: 1794 LAQAEAE 1800
Score = 57.8 bits (138), Expect = 1e-07
Identities = 95/391 (24%), Positives = 160/391 (40%), Gaps = 44/391 (11%)
Query: 132 ELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVV 191
E QR A + E Q R S +T + R L+ ++ +A + + E RA++ E
Sbjct: 1705 ETAQRSA--EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1762
Query: 192 SAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKE 251
A L+ R +A ++++ S A+ A Q+E E +AR GK
Sbjct: 1763 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE----AEKQKEEAEREARRR--GKA 1816
Query: 252 GPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGA 311
Q + R+ E QR++ Q L ++E + L A
Sbjct: 1817 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR----------------AETE 1860
Query: 312 PGEATPQEDADNLPVILGEPEKE-QRVQQLESELSKKRKKCESL---EQEARKKQRRCEE 367
GE Q + L + E Q+ Q+LE+EL+K R + E L + A ++ R E
Sbjct: 1861 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1920
Query: 368 LELQLRQAQNENAR-LVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQG 426
Q +A+ R L EE +RL A E A+ + QL E D+A ++++
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRALA--------EEAKRQRQLA----EEDAARQRAEA 1968
Query: 427 ---LQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREH 483
L KL ++ + + E ++ E E+E+ R ++ + RRL++ A+ + +
Sbjct: 1969 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 2028
Query: 484 EGAVQLLESTLDSMQARVRELEEQCRSQTEQ 514
E + L DS R + L E Q Q
Sbjct: 2029 EERLAQLRKASDSELERQKGLVEDTLRQRRQ 2059
Score = 51.6 bits (122), Expect = 7e-06
Identities = 103/485 (21%), Positives = 194/485 (40%), Gaps = 70/485 (14%)
Query: 76 DPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQ 135
D E A C + +Q + EVE K +S E + AL E
Sbjct: 1149 DKEPARECAQRIAEQQKAQA---------EVEGLGKGVARLS----AEAEKVLALPEPSP 1195
Query: 136 RCAILKEENQM-LRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAP 194
L+ E ++ L K + + K K L + + E + E L+ A
Sbjct: 1196 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA- 1254
Query: 195 LPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQ 254
+P LE + +L + RA+ ++ + +D ++ Q LQ R E +
Sbjct: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRD-ELRGAQEVGERLQQRHGERDVEVER 1313
Query: 255 WLH-----VRDFDRLLRES---QREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGA 306
W + + +L ++ QRE+ +L RQ LR RE+ P G LQ
Sbjct: 1314 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQ--LRYYRESAD-----PLGAWLQ----- 1361
Query: 307 PAPGAPGEATPQEDADNLPVILGEPEKEQ--RVQQLESELSKKRKKCESLEQEARKKQRR 364
QE +P+ + +EQ + Q L E+ + +K E ++ A++
Sbjct: 1362 ------DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1415
Query: 365 CEELELQL----------------RQAQNENARLVEENSRLSGRATEKEQVEWENAELRG 408
++ ELQL + Q+ + +++E L +E + + +
Sbjct: 1416 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1475
Query: 409 QLLGVTQERDSALRKSQGLQ-SKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREK-Q 466
+ L +E + + + + +L +E L+ R++A+ Q + + E+ L+++ Q
Sbjct: 1476 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1535
Query: 467 EEVRRLQQAQAEAQRE----HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQEL 522
EEV R ++A +AQ++ E QL +S+ +QA+ R+ E RS+ + +E+
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR----IEEEI 1591
Query: 523 QAFRL 527
+ RL
Sbjct: 1592 RVVRL 1596
Score = 45.1 bits (105), Expect = 7e-04
Identities = 120/502 (23%), Positives = 203/502 (40%), Gaps = 86/502 (17%)
Query: 34 EPSSAAPSIADTPPAAL-QLQELRSEESSK-PKGDGSSRPVGGTDPEGAEACLPSLGQQA 91
EPS AAP++ L +L+++RS + K S + GT +GAE L + +Q
Sbjct: 1192 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQL 1249
Query: 92 SSSGPA-CQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKS 150
+ PE E +A LK + +P + LR ELR +E + L++
Sbjct: 1250 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR--DELRGA----QEVGERLQQR 1303
Query: 151 SFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALA 210
E + +V R + + A+L LE L +T++R L + G L R++
Sbjct: 1304 H-GERDVEVERWRERVAQL------LERWQAVLAQTDVR--QRELEQLGRQLRYYRESAD 1354
Query: 211 R-----QRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLL 265
Q AR E A+ D Q A++ + R+ QA L + + G + V + R
Sbjct: 1355 PLGAWLQDARRRQEQIQAMPLADSQ--AVREQLRQEQALLEEIERHGEK---VEECQRFA 1409
Query: 266 RESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLP 325
++ + + Q+ + L P P + ++G+ E+ QE D
Sbjct: 1410 KQYINAIKDYELQLVTYKAQ----LEPVASPAKKPKVQSGS-------ESVIQEYVD--- 1455
Query: 326 VILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEE 385
+ E Q +S+ ++ E E+E +Q+R EE E R A+ E A L ++
Sbjct: 1456 LRTHYSELTTLTSQYIKFISETLRRME--EEERLAEQQRAEERE---RLAEVE-AALEKQ 1509
Query: 386 NSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVA 445
A K Q E E EL+ + M+E
Sbjct: 1510 RQLAEAHAQAKAQAEREAKELQ-------------------------------QRMQEEV 1538
Query: 446 QRRQQLEVEHEQARLSLREKQEEVRRLQQ-AQAEAQREHEGAVQLLESTLDSMQARVREL 504
RR++ V+ +Q + S+ QEE+++L+Q ++AE Q + A S L ++ +R +
Sbjct: 1539 VRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVV 1594
Query: 505 EEQCRSQTEQFSLLAQELQAFR 526
Q + Q ELQA R
Sbjct: 1595 RLQLEATERQRGGAEGELQALR 1616
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 75.1 bits (183), Expect = 6e-13
Identities = 111/454 (24%), Positives = 184/454 (40%), Gaps = 33/454 (7%)
Query: 99 QRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAIL-----KEENQMLRKSSFP 153
QR + EE LKA + + LEL LG +R + E + R+
Sbjct: 1897 QRRQVEEEILALKASFEKAAAGKAELEL--ELGRIRSNAEDTLRSKEQAELEAARQRQLA 1954
Query: 154 ETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQR 213
EE+ RR + + ++ A+ R RK + + A + E + ARQ
Sbjct: 1955 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2014
Query: 214 ARDLSETASALLAKDKQIA-ALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREV 272
L A++K A A+Q++ +ELQ L Q + R E E
Sbjct: 2015 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2074
Query: 273 LRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPE 332
R+Q + R + QA+A A A A + + + + E
Sbjct: 2075 -RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2133
Query: 333 KEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGR 392
++ Q ++E+ K +K E ++ + ++ L LQL + ++ L EE RL
Sbjct: 2134 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2193
Query: 393 ATE----KEQVEWENAELRGQL--LGVTQERDSALRKSQGLQSKLES---LEQVLKHMRE 443
ATE + QVE E +R Q+ L + R A ++ L+ K + L++ + M++
Sbjct: 2194 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2253
Query: 444 VAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ-REHEGAVQ----------LLES 492
VA+ +L V ++A LR+ EE Q+A AE +E AVQ LL+
Sbjct: 2254 VAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2312
Query: 493 TLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR 526
+ Q + R L+E +Q LA+E Q F+
Sbjct: 2313 QKELAQEQARRLQEDKEQMAQQ---LAEETQGFQ 2343
Score = 73.2 bits (178), Expect = 2e-12
Identities = 109/464 (23%), Positives = 198/464 (42%), Gaps = 61/464 (13%)
Query: 90 QASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRK 149
+A ++ A QR + EE ++ ++ L L+A E R IL++++ R
Sbjct: 2191 KAEATEAARQRSQVEEELFSVRVQME-------ELSKLKARIEAENRALILRDKDNTQR- 2242
Query: 150 SSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKAL 209
E EK++++ + A L+V A+ R R+L E +L A + L K
Sbjct: 2243 -FLQEEAEKMKQVAEEAARLSVAAQEAA-RLRQLAEEDLAQQRALAEKM-----LKEKMQ 2295
Query: 210 ARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQ 269
A Q A L A LL + K++A Q + R LQ + ++ + + F R L E++
Sbjct: 2296 AVQEATRLKAEAE-LLQQQKELA--QEQARRLQEDKEQMAQQLAE--ETQGFQRTL-EAE 2349
Query: 270 REVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILG 329
R QRQ+ + + E L L A +RA A A +EDA
Sbjct: 2350 R-----QRQLEMSAEAERLKLRV------AEMSRAQARA---------EEDAQRFRK--Q 2387
Query: 330 EPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRL 389
E +++ + E +K ++LE + ++ E L + + + E +L +E L
Sbjct: 2388 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2447
Query: 390 SGRATEKEQVEWENAELRGQLL--GVTQERDSALRKSQGLQSKLESLEQVL--------- 438
++ E + V+ E Q L E+DS L++ + ++ + LEQ+
Sbjct: 2448 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2507
Query: 439 ------KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLES 492
+ +++ Q RQ+L E+AR E +E VRR Q+ + +++ +LL
Sbjct: 2508 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2567
Query: 493 TLDSMQARVRELEEQCRSQ-TEQFSLLAQELQAFRLHPGPLDLL 535
++ +++ LEEQ R+ + A ++ A + P D L
Sbjct: 2568 ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2611
Score = 67.8 bits (164), Expect = 9e-11
Identities = 104/429 (24%), Positives = 173/429 (40%), Gaps = 61/429 (14%)
Query: 129 ALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNL 188
A G +QR A E +++R + E E+ R+L + ELA + + +K QE
Sbjct: 1679 AEGTAQQRLAA---EQELIRLRAETEQGEQQRQLLEE--ELARLQREAAAATQKRQELEA 1733
Query: 189 RVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLV 248
+ R + L KA A + +R SE + L + A RE E ARL +
Sbjct: 1734 ELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRAL 1787
Query: 249 GKEGPQWLHVRDFD---------RLLRESQREV-----LRLQRQIALRNQRETLPLPPSW 294
+E + + + D R+L E + L+ + +IAL+ +
Sbjct: 1788 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1847
Query: 295 PPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESL 354
A Q R E Q AD E+R+ QL + ++ + L
Sbjct: 1848 AEDEAFQRRRLE-------EQAAQHKADI----------EERLAQLRKASDSELERQKGL 1890
Query: 355 EQEARKKQRRCEE----LELQLRQAQNENARLVEENSRLSGRATE----KEQVEWENAEL 406
++ +++R+ EE L+ +A A L E R+ A + KEQ E E A
Sbjct: 1891 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1950
Query: 407 RGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQAR-LSLREK 465
R QL +E + +Q L + E+ + + + ++L+ + E+AR L R +
Sbjct: 1951 R-QL--AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2007
Query: 466 QEEVRRLQQAQAEAQRE-------HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLL 518
QE R+LQ AQ AQ+ H AVQ E L + + + +Q R + E
Sbjct: 2008 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2067
Query: 519 AQELQAFRL 527
A+E + R+
Sbjct: 2068 AEEAEEARV 2076
Score = 60.5 bits (145), Expect = 2e-08
Identities = 94/367 (25%), Positives = 150/367 (40%), Gaps = 68/367 (18%)
Query: 174 KRLEERARKLQETNLRVVSAPLPRPGTSLELCR--KALARQRARDLSETASALLAKDKQI 231
+RL E+ R + L V A L + E KA A + A++L + + + ++
Sbjct: 1326 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1385
Query: 232 AA-LQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQI-ALRNQRETLP 289
A Q++ R +Q L + + + + R ++R LR++ +I +R Q E
Sbjct: 1386 AVDAQQQKRSIQEELQQLRQSSEAEIQAKA--RQAEAAERSRLRIEEEIRVVRLQLEATE 1443
Query: 290 LPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRK 349
G RA A A + QE+A+ L + ++ QR +Q E EL+ R
Sbjct: 1444 RQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQV--QDESQRKRQAEVELAS-RV 1499
Query: 350 KCESLEQEARKKQR----------RCEELELQLRQAQNENARLVEENSRLSGRATEKEQV 399
K E+ + AR+KQR + EE E +LRQA+ E AR V+ + R+ E E
Sbjct: 1500 KAEA--EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE-- 1555
Query: 400 EWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQAR 459
LQSK S A++ QLE ++
Sbjct: 1556 ---------------------------LQSKRASF----------AEKTAQLERSLQEEH 1578
Query: 460 LSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRE---LEEQCRSQTEQFS 516
+++ + +EE R Q QAEA+R E A E L+ Q + E L Q +Q S
Sbjct: 1579 VAVAQLREEAERRAQQQAEAERAREEA----ERELERWQLKANEALRLRLQAEEVAQQKS 1634
Query: 517 LLAQELQ 523
L E +
Sbjct: 1635 LAQAEAE 1641
Score = 57.8 bits (138), Expect = 1e-07
Identities = 95/391 (24%), Positives = 160/391 (40%), Gaps = 44/391 (11%)
Query: 132 ELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVV 191
E QR A + E Q R S +T + R L+ ++ +A + + E RA++ E
Sbjct: 1546 ETAQRSA--EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1603
Query: 192 SAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKE 251
A L+ R +A ++++ S A+ A Q+E E +AR GK
Sbjct: 1604 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE----AEKQKEEAEREARRR--GKA 1657
Query: 252 GPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGA 311
Q + R+ E QR++ Q L ++E + L A
Sbjct: 1658 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR----------------AETE 1701
Query: 312 PGEATPQEDADNLPVILGEPEKE-QRVQQLESELSKKRKKCESL---EQEARKKQRRCEE 367
GE Q + L + E Q+ Q+LE+EL+K R + E L + A ++ R E
Sbjct: 1702 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1761
Query: 368 LELQLRQAQNENAR-LVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQG 426
Q +A+ R L EE +RL A E A+ + QL E D+A ++++
Sbjct: 1762 KSKQRLEAEAGRFRELAEEAARLRALA--------EEAKRQRQLA----EEDAARQRAEA 1809
Query: 427 ---LQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREH 483
L KL ++ + + E ++ E E+E+ R ++ + RRL++ A+ + +
Sbjct: 1810 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1869
Query: 484 EGAVQLLESTLDSMQARVRELEEQCRSQTEQ 514
E + L DS R + L E Q Q
Sbjct: 1870 EERLAQLRKASDSELERQKGLVEDTLRQRRQ 1900
Score = 51.6 bits (122), Expect = 7e-06
Identities = 103/485 (21%), Positives = 194/485 (40%), Gaps = 70/485 (14%)
Query: 76 DPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQ 135
D E A C + +Q + EVE K +S E + AL E
Sbjct: 990 DKEPARECAQRIAEQQKAQA---------EVEGLGKGVARLS----AEAEKVLALPEPSP 1036
Query: 136 RCAILKEENQM-LRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAP 194
L+ E ++ L K + + K K L + + E + E L+ A
Sbjct: 1037 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA- 1095
Query: 195 LPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQ 254
+P LE + +L + RA+ ++ + +D ++ Q LQ R E +
Sbjct: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRD-ELRGAQEVGERLQQRHGERDVEVER 1154
Query: 255 WLH-----VRDFDRLLRES---QREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGA 306
W + + +L ++ QRE+ +L RQ LR RE+ P G LQ
Sbjct: 1155 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQ--LRYYRESAD-----PLGAWLQ----- 1202
Query: 307 PAPGAPGEATPQEDADNLPVILGEPEKEQ--RVQQLESELSKKRKKCESLEQEARKKQRR 364
QE +P+ + +EQ + Q L E+ + +K E ++ A++
Sbjct: 1203 ------DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1256
Query: 365 CEELELQL----------------RQAQNENARLVEENSRLSGRATEKEQVEWENAELRG 408
++ ELQL + Q+ + +++E L +E + + +
Sbjct: 1257 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1316
Query: 409 QLLGVTQERDSALRKSQGLQ-SKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREK-Q 466
+ L +E + + + + +L +E L+ R++A+ Q + + E+ L+++ Q
Sbjct: 1317 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1376
Query: 467 EEVRRLQQAQAEAQRE----HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQEL 522
EEV R ++A +AQ++ E QL +S+ +QA+ R+ E RS+ + +E+
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR----IEEEI 1432
Query: 523 QAFRL 527
+ RL
Sbjct: 1433 RVVRL 1437
Score = 45.1 bits (105), Expect = 7e-04
Identities = 120/502 (23%), Positives = 203/502 (40%), Gaps = 86/502 (17%)
Query: 34 EPSSAAPSIADTPPAAL-QLQELRSEESSK-PKGDGSSRPVGGTDPEGAEACLPSLGQQA 91
EPS AAP++ L +L+++RS + K S + GT +GAE L + +Q
Sbjct: 1033 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQL 1090
Query: 92 SSSGPA-CQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKS 150
+ PE E +A LK + +P + LR ELR +E + L++
Sbjct: 1091 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR--DELRGA----QEVGERLQQR 1144
Query: 151 SFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALA 210
E + +V R + + A+L LE L +T++R L + G L R++
Sbjct: 1145 H-GERDVEVERWRERVAQL------LERWQAVLAQTDVR--QRELEQLGRQLRYYRESAD 1195
Query: 211 R-----QRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLL 265
Q AR E A+ D Q A++ + R+ QA L + + G + V + R
Sbjct: 1196 PLGAWLQDARRRQEQIQAMPLADSQ--AVREQLRQEQALLEEIERHGEK---VEECQRFA 1250
Query: 266 RESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLP 325
++ + + Q+ + L P P + ++G+ E+ QE D
Sbjct: 1251 KQYINAIKDYELQLVTYKAQ----LEPVASPAKKPKVQSGS-------ESVIQEYVD--- 1296
Query: 326 VILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEE 385
+ E Q +S+ ++ E E+E +Q+R EE E R A+ E A L ++
Sbjct: 1297 LRTHYSELTTLTSQYIKFISETLRRME--EEERLAEQQRAEERE---RLAEVE-AALEKQ 1350
Query: 386 NSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVA 445
A K Q E E EL+ + M+E
Sbjct: 1351 RQLAEAHAQAKAQAEREAKELQ-------------------------------QRMQEEV 1379
Query: 446 QRRQQLEVEHEQARLSLREKQEEVRRLQQ-AQAEAQREHEGAVQLLESTLDSMQARVREL 504
RR++ V+ +Q + S+ QEE+++L+Q ++AE Q + A S L ++ +R +
Sbjct: 1380 VRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVV 1435
Query: 505 EEQCRSQTEQFSLLAQELQAFR 526
Q + Q ELQA R
Sbjct: 1436 RLQLEATERQRGGAEGELQALR 1457
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 75.1 bits (183), Expect = 6e-13
Identities = 111/454 (24%), Positives = 184/454 (40%), Gaps = 33/454 (7%)
Query: 99 QRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAIL-----KEENQMLRKSSFP 153
QR + EE LKA + + LEL LG +R + E + R+
Sbjct: 1905 QRRQVEEEILALKASFEKAAAGKAELEL--ELGRIRSNAEDTLRSKEQAELEAARQRQLA 1962
Query: 154 ETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQR 213
EE+ RR + + ++ A+ R RK + + A + E + ARQ
Sbjct: 1963 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2022
Query: 214 ARDLSETASALLAKDKQIA-ALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREV 272
L A++K A A+Q++ +ELQ L Q + R E E
Sbjct: 2023 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2082
Query: 273 LRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPE 332
R+Q + R + QA+A A A A + + + + E
Sbjct: 2083 -RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2141
Query: 333 KEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGR 392
++ Q ++E+ K +K E ++ + ++ L LQL + ++ L EE RL
Sbjct: 2142 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2201
Query: 393 ATE----KEQVEWENAELRGQL--LGVTQERDSALRKSQGLQSKLES---LEQVLKHMRE 443
ATE + QVE E +R Q+ L + R A ++ L+ K + L++ + M++
Sbjct: 2202 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2261
Query: 444 VAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ-REHEGAVQ----------LLES 492
VA+ +L V ++A LR+ EE Q+A AE +E AVQ LL+
Sbjct: 2262 VAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2320
Query: 493 TLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR 526
+ Q + R L+E +Q LA+E Q F+
Sbjct: 2321 QKELAQEQARRLQEDKEQMAQQ---LAEETQGFQ 2351
Score = 73.2 bits (178), Expect = 2e-12
Identities = 109/464 (23%), Positives = 198/464 (42%), Gaps = 61/464 (13%)
Query: 90 QASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRK 149
+A ++ A QR + EE ++ ++ L L+A E R IL++++ R
Sbjct: 2199 KAEATEAARQRSQVEEELFSVRVQME-------ELSKLKARIEAENRALILRDKDNTQR- 2250
Query: 150 SSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKAL 209
E EK++++ + A L+V A+ R R+L E +L A + L K
Sbjct: 2251 -FLQEEAEKMKQVAEEAARLSVAAQEAA-RLRQLAEEDLAQQRALAEKM-----LKEKMQ 2303
Query: 210 ARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQ 269
A Q A L A LL + K++A Q + R LQ + ++ + + F R L E++
Sbjct: 2304 AVQEATRLKAEAE-LLQQQKELA--QEQARRLQEDKEQMAQQLAE--ETQGFQRTL-EAE 2357
Query: 270 REVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILG 329
R QRQ+ + + E L L A +RA A A +EDA
Sbjct: 2358 R-----QRQLEMSAEAERLKLRV------AEMSRAQARA---------EEDAQRFRK--Q 2395
Query: 330 EPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRL 389
E +++ + E +K ++LE + ++ E L + + + E +L +E L
Sbjct: 2396 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2455
Query: 390 SGRATEKEQVEWENAELRGQLL--GVTQERDSALRKSQGLQSKLESLEQVL--------- 438
++ E + V+ E Q L E+DS L++ + ++ + LEQ+
Sbjct: 2456 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2515
Query: 439 ------KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLES 492
+ +++ Q RQ+L E+AR E +E VRR Q+ + +++ +LL
Sbjct: 2516 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2575
Query: 493 TLDSMQARVRELEEQCRSQ-TEQFSLLAQELQAFRLHPGPLDLL 535
++ +++ LEEQ R+ + A ++ A + P D L
Sbjct: 2576 ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2619
Score = 67.8 bits (164), Expect = 9e-11
Identities = 104/429 (24%), Positives = 173/429 (40%), Gaps = 61/429 (14%)
Query: 129 ALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNL 188
A G +QR A E +++R + E E+ R+L + ELA + + +K QE
Sbjct: 1687 AEGTAQQRLAA---EQELIRLRAETEQGEQQRQLLEE--ELARLQREAAAATQKRQELEA 1741
Query: 189 RVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLV 248
+ R + L KA A + +R SE + L + A RE E ARL +
Sbjct: 1742 ELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRAL 1795
Query: 249 GKEGPQWLHVRDFD---------RLLRESQREV-----LRLQRQIALRNQRETLPLPPSW 294
+E + + + D R+L E + L+ + +IAL+ +
Sbjct: 1796 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1855
Query: 295 PPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESL 354
A Q R E Q AD E+R+ QL + ++ + L
Sbjct: 1856 AEDEAFQRRRLE-------EQAAQHKADI----------EERLAQLRKASDSELERQKGL 1898
Query: 355 EQEARKKQRRCEE----LELQLRQAQNENARLVEENSRLSGRATE----KEQVEWENAEL 406
++ +++R+ EE L+ +A A L E R+ A + KEQ E E A
Sbjct: 1899 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1958
Query: 407 RGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQAR-LSLREK 465
R QL +E + +Q L + E+ + + + ++L+ + E+AR L R +
Sbjct: 1959 R-QL--AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2015
Query: 466 QEEVRRLQQAQAEAQRE-------HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLL 518
QE R+LQ AQ AQ+ H AVQ E L + + + +Q R + E
Sbjct: 2016 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2075
Query: 519 AQELQAFRL 527
A+E + R+
Sbjct: 2076 AEEAEEARV 2084
Score = 60.5 bits (145), Expect = 2e-08
Identities = 94/367 (25%), Positives = 150/367 (40%), Gaps = 68/367 (18%)
Query: 174 KRLEERARKLQETNLRVVSAPLPRPGTSLELCR--KALARQRARDLSETASALLAKDKQI 231
+RL E+ R + L V A L + E KA A + A++L + + + ++
Sbjct: 1334 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1393
Query: 232 AA-LQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQI-ALRNQRETLP 289
A Q++ R +Q L + + + + R ++R LR++ +I +R Q E
Sbjct: 1394 AVDAQQQKRSIQEELQQLRQSSEAEIQAKA--RQAEAAERSRLRIEEEIRVVRLQLEATE 1451
Query: 290 LPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRK 349
G RA A A + QE+A+ L + ++ QR +Q E EL+ R
Sbjct: 1452 RQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQV--QDESQRKRQAEVELAS-RV 1507
Query: 350 KCESLEQEARKKQR----------RCEELELQLRQAQNENARLVEENSRLSGRATEKEQV 399
K E+ + AR+KQR + EE E +LRQA+ E AR V+ + R+ E E
Sbjct: 1508 KAEA--EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE-- 1563
Query: 400 EWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQAR 459
LQSK S A++ QLE ++
Sbjct: 1564 ---------------------------LQSKRASF----------AEKTAQLERSLQEEH 1586
Query: 460 LSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRE---LEEQCRSQTEQFS 516
+++ + +EE R Q QAEA+R E A E L+ Q + E L Q +Q S
Sbjct: 1587 VAVAQLREEAERRAQQQAEAERAREEA----ERELERWQLKANEALRLRLQAEEVAQQKS 1642
Query: 517 LLAQELQ 523
L E +
Sbjct: 1643 LAQAEAE 1649
Score = 57.8 bits (138), Expect = 1e-07
Identities = 95/391 (24%), Positives = 160/391 (40%), Gaps = 44/391 (11%)
Query: 132 ELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVV 191
E QR A + E Q R S +T + R L+ ++ +A + + E RA++ E
Sbjct: 1554 ETAQRSA--EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1611
Query: 192 SAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKE 251
A L+ R +A ++++ S A+ A Q+E E +AR GK
Sbjct: 1612 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE----AEKQKEEAEREARRR--GKA 1665
Query: 252 GPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGA 311
Q + R+ E QR++ Q L ++E + L A
Sbjct: 1666 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR----------------AETE 1709
Query: 312 PGEATPQEDADNLPVILGEPEKE-QRVQQLESELSKKRKKCESL---EQEARKKQRRCEE 367
GE Q + L + E Q+ Q+LE+EL+K R + E L + A ++ R E
Sbjct: 1710 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1769
Query: 368 LELQLRQAQNENAR-LVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQG 426
Q +A+ R L EE +RL A E A+ + QL E D+A ++++
Sbjct: 1770 KSKQRLEAEAGRFRELAEEAARLRALA--------EEAKRQRQLA----EEDAARQRAEA 1817
Query: 427 ---LQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREH 483
L KL ++ + + E ++ E E+E+ R ++ + RRL++ A+ + +
Sbjct: 1818 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1877
Query: 484 EGAVQLLESTLDSMQARVRELEEQCRSQTEQ 514
E + L DS R + L E Q Q
Sbjct: 1878 EERLAQLRKASDSELERQKGLVEDTLRQRRQ 1908
Score = 51.6 bits (122), Expect = 7e-06
Identities = 103/485 (21%), Positives = 194/485 (40%), Gaps = 70/485 (14%)
Query: 76 DPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQ 135
D E A C + +Q + EVE K +S E + AL E
Sbjct: 998 DKEPARECAQRIAEQQKAQA---------EVEGLGKGVARLS----AEAEKVLALPEPSP 1044
Query: 136 RCAILKEENQM-LRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAP 194
L+ E ++ L K + + K K L + + E + E L+ A
Sbjct: 1045 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA- 1103
Query: 195 LPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQ 254
+P LE + +L + RA+ ++ + +D ++ Q LQ R E +
Sbjct: 1104 VPATLPELEATKASLKKLRAQAEAQQPTFDALRD-ELRGAQEVGERLQQRHGERDVEVER 1162
Query: 255 WLH-----VRDFDRLLRES---QREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGA 306
W + + +L ++ QRE+ +L RQ LR RE+ P G LQ
Sbjct: 1163 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQ--LRYYRESAD-----PLGAWLQ----- 1210
Query: 307 PAPGAPGEATPQEDADNLPVILGEPEKEQ--RVQQLESELSKKRKKCESLEQEARKKQRR 364
QE +P+ + +EQ + Q L E+ + +K E ++ A++
Sbjct: 1211 ------DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1264
Query: 365 CEELELQL----------------RQAQNENARLVEENSRLSGRATEKEQVEWENAELRG 408
++ ELQL + Q+ + +++E L +E + + +
Sbjct: 1265 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1324
Query: 409 QLLGVTQERDSALRKSQGLQ-SKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREK-Q 466
+ L +E + + + + +L +E L+ R++A+ Q + + E+ L+++ Q
Sbjct: 1325 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1384
Query: 467 EEVRRLQQAQAEAQRE----HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQEL 522
EEV R ++A +AQ++ E QL +S+ +QA+ R+ E RS+ + +E+
Sbjct: 1385 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR----IEEEI 1440
Query: 523 QAFRL 527
+ RL
Sbjct: 1441 RVVRL 1445
Score = 45.1 bits (105), Expect = 7e-04
Identities = 120/502 (23%), Positives = 203/502 (40%), Gaps = 86/502 (17%)
Query: 34 EPSSAAPSIADTPPAAL-QLQELRSEESSK-PKGDGSSRPVGGTDPEGAEACLPSLGQQA 91
EPS AAP++ L +L+++RS + K S + GT +GAE L + +Q
Sbjct: 1041 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQL 1098
Query: 92 SSSGPA-CQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKS 150
+ PE E +A LK + +P + LR ELR +E + L++
Sbjct: 1099 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR--DELRGA----QEVGERLQQR 1152
Query: 151 SFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALA 210
E + +V R + + A+L LE L +T++R L + G L R++
Sbjct: 1153 H-GERDVEVERWRERVAQL------LERWQAVLAQTDVR--QRELEQLGRQLRYYRESAD 1203
Query: 211 R-----QRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLL 265
Q AR E A+ D Q A++ + R+ QA L + + G + V + R
Sbjct: 1204 PLGAWLQDARRRQEQIQAMPLADSQ--AVREQLRQEQALLEEIERHGEK---VEECQRFA 1258
Query: 266 RESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLP 325
++ + + Q+ + L P P + ++G+ E+ QE D
Sbjct: 1259 KQYINAIKDYELQLVTYKAQ----LEPVASPAKKPKVQSGS-------ESVIQEYVD--- 1304
Query: 326 VILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEE 385
+ E Q +S+ ++ E E+E +Q+R EE E R A+ E A L ++
Sbjct: 1305 LRTHYSELTTLTSQYIKFISETLRRME--EEERLAEQQRAEERE---RLAEVE-AALEKQ 1358
Query: 386 NSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVA 445
A K Q E E EL+ + M+E
Sbjct: 1359 RQLAEAHAQAKAQAEREAKELQ-------------------------------QRMQEEV 1387
Query: 446 QRRQQLEVEHEQARLSLREKQEEVRRLQQ-AQAEAQREHEGAVQLLESTLDSMQARVREL 504
RR++ V+ +Q + S+ QEE+++L+Q ++AE Q + A S L ++ +R +
Sbjct: 1388 VRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVV 1443
Query: 505 EEQCRSQTEQFSLLAQELQAFR 526
Q + Q ELQA R
Sbjct: 1444 RLQLEATERQRGGAEGELQALR 1465
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 75.1 bits (183), Expect = 6e-13
Identities = 111/454 (24%), Positives = 184/454 (40%), Gaps = 33/454 (7%)
Query: 99 QRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAIL-----KEENQMLRKSSFP 153
QR + EE LKA + + LEL LG +R + E + R+
Sbjct: 1946 QRRQVEEEILALKASFEKAAAGKAELEL--ELGRIRSNAEDTLRSKEQAELEAARQRQLA 2003
Query: 154 ETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQR 213
EE+ RR + + ++ A+ R RK + + A + E + ARQ
Sbjct: 2004 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2063
Query: 214 ARDLSETASALLAKDKQIA-ALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREV 272
L A++K A A+Q++ +ELQ L Q + R E E
Sbjct: 2064 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2123
Query: 273 LRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPE 332
R+Q + R + QA+A A A A + + + + E
Sbjct: 2124 -RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2182
Query: 333 KEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGR 392
++ Q ++E+ K +K E ++ + ++ L LQL + ++ L EE RL
Sbjct: 2183 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2242
Query: 393 ATE----KEQVEWENAELRGQL--LGVTQERDSALRKSQGLQSKLES---LEQVLKHMRE 443
ATE + QVE E +R Q+ L + R A ++ L+ K + L++ + M++
Sbjct: 2243 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2302
Query: 444 VAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ-REHEGAVQ----------LLES 492
VA+ +L V ++A LR+ EE Q+A AE +E AVQ LL+
Sbjct: 2303 VAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2361
Query: 493 TLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR 526
+ Q + R L+E +Q LA+E Q F+
Sbjct: 2362 QKELAQEQARRLQEDKEQMAQQ---LAEETQGFQ 2392
Score = 73.2 bits (178), Expect = 2e-12
Identities = 109/464 (23%), Positives = 198/464 (42%), Gaps = 61/464 (13%)
Query: 90 QASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRK 149
+A ++ A QR + EE ++ ++ L L+A E R IL++++ R
Sbjct: 2240 KAEATEAARQRSQVEEELFSVRVQME-------ELSKLKARIEAENRALILRDKDNTQR- 2291
Query: 150 SSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKAL 209
E EK++++ + A L+V A+ R R+L E +L A + L K
Sbjct: 2292 -FLQEEAEKMKQVAEEAARLSVAAQEAA-RLRQLAEEDLAQQRALAEKM-----LKEKMQ 2344
Query: 210 ARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQ 269
A Q A L A LL + K++A Q + R LQ + ++ + + F R L E++
Sbjct: 2345 AVQEATRLKAEAE-LLQQQKELA--QEQARRLQEDKEQMAQQLAE--ETQGFQRTL-EAE 2398
Query: 270 REVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILG 329
R QRQ+ + + E L L A +RA A A +EDA
Sbjct: 2399 R-----QRQLEMSAEAERLKLRV------AEMSRAQARA---------EEDAQRFRK--Q 2436
Query: 330 EPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRL 389
E +++ + E +K ++LE + ++ E L + + + E +L +E L
Sbjct: 2437 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2496
Query: 390 SGRATEKEQVEWENAELRGQLL--GVTQERDSALRKSQGLQSKLESLEQVL--------- 438
++ E + V+ E Q L E+DS L++ + ++ + LEQ+
Sbjct: 2497 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2556
Query: 439 ------KHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLES 492
+ +++ Q RQ+L E+AR E +E VRR Q+ + +++ +LL
Sbjct: 2557 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2616
Query: 493 TLDSMQARVRELEEQCRSQ-TEQFSLLAQELQAFRLHPGPLDLL 535
++ +++ LEEQ R+ + A ++ A + P D L
Sbjct: 2617 ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2660
Score = 67.8 bits (164), Expect = 9e-11
Identities = 104/429 (24%), Positives = 173/429 (40%), Gaps = 61/429 (14%)
Query: 129 ALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNL 188
A G +QR A E +++R + E E+ R+L + ELA + + +K QE
Sbjct: 1728 AEGTAQQRLAA---EQELIRLRAETEQGEQQRQLLEE--ELARLQREAAAATQKRQELEA 1782
Query: 189 RVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLV 248
+ R + L KA A + +R SE + L + A RE E ARL +
Sbjct: 1783 ELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRAL 1836
Query: 249 GKEGPQWLHVRDFD---------RLLRESQREV-----LRLQRQIALRNQRETLPLPPSW 294
+E + + + D R+L E + L+ + +IAL+ +
Sbjct: 1837 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1896
Query: 295 PPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESL 354
A Q R E Q AD E+R+ QL + ++ + L
Sbjct: 1897 AEDEAFQRRRLE-------EQAAQHKADI----------EERLAQLRKASDSELERQKGL 1939
Query: 355 EQEARKKQRRCEE----LELQLRQAQNENARLVEENSRLSGRATE----KEQVEWENAEL 406
++ +++R+ EE L+ +A A L E R+ A + KEQ E E A
Sbjct: 1940 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1999
Query: 407 RGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQAR-LSLREK 465
R QL +E + +Q L + E+ + + + ++L+ + E+AR L R +
Sbjct: 2000 R-QL--AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2056
Query: 466 QEEVRRLQQAQAEAQRE-------HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLL 518
QE R+LQ AQ AQ+ H AVQ E L + + + +Q R + E
Sbjct: 2057 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2116
Query: 519 AQELQAFRL 527
A+E + R+
Sbjct: 2117 AEEAEEARV 2125
Score = 60.5 bits (145), Expect = 2e-08
Identities = 94/367 (25%), Positives = 150/367 (40%), Gaps = 68/367 (18%)
Query: 174 KRLEERARKLQETNLRVVSAPLPRPGTSLELCR--KALARQRARDLSETASALLAKDKQI 231
+RL E+ R + L V A L + E KA A + A++L + + + ++
Sbjct: 1375 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1434
Query: 232 AA-LQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQI-ALRNQRETLP 289
A Q++ R +Q L + + + + R ++R LR++ +I +R Q E
Sbjct: 1435 AVDAQQQKRSIQEELQQLRQSSEAEIQAKA--RQAEAAERSRLRIEEEIRVVRLQLEATE 1492
Query: 290 LPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRK 349
G RA A A + QE+A+ L + ++ QR +Q E EL+ R
Sbjct: 1493 RQRGGAEGELQALRARAEEAEAQ-KRQAQEEAERLRRQV--QDESQRKRQAEVELAS-RV 1548
Query: 350 KCESLEQEARKKQR----------RCEELELQLRQAQNENARLVEENSRLSGRATEKEQV 399
K E+ + AR+KQR + EE E +LRQA+ E AR V+ + R+ E E
Sbjct: 1549 KAEA--EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE-- 1604
Query: 400 EWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQAR 459
LQSK S A++ QLE ++
Sbjct: 1605 ---------------------------LQSKRASF----------AEKTAQLERSLQEEH 1627
Query: 460 LSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRE---LEEQCRSQTEQFS 516
+++ + +EE R Q QAEA+R E A E L+ Q + E L Q +Q S
Sbjct: 1628 VAVAQLREEAERRAQQQAEAERAREEA----ERELERWQLKANEALRLRLQAEEVAQQKS 1683
Query: 517 LLAQELQ 523
L E +
Sbjct: 1684 LAQAEAE 1690
Score = 57.8 bits (138), Expect = 1e-07
Identities = 95/391 (24%), Positives = 160/391 (40%), Gaps = 44/391 (11%)
Query: 132 ELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVV 191
E QR A + E Q R S +T + R L+ ++ +A + + E RA++ E
Sbjct: 1595 ETAQRSA--EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1652
Query: 192 SAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKE 251
A L+ R +A ++++ S A+ A Q+E E +AR GK
Sbjct: 1653 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE----AEKQKEEAEREARRR--GKA 1706
Query: 252 GPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGA 311
Q + R+ E QR++ Q L ++E + L A
Sbjct: 1707 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR----------------AETE 1750
Query: 312 PGEATPQEDADNLPVILGEPEKE-QRVQQLESELSKKRKKCESL---EQEARKKQRRCEE 367
GE Q + L + E Q+ Q+LE+EL+K R + E L + A ++ R E
Sbjct: 1751 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1810
Query: 368 LELQLRQAQNENAR-LVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQG 426
Q +A+ R L EE +RL A E A+ + QL E D+A ++++
Sbjct: 1811 KSKQRLEAEAGRFRELAEEAARLRALA--------EEAKRQRQLA----EEDAARQRAEA 1858
Query: 427 ---LQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREH 483
L KL ++ + + E ++ E E+E+ R ++ + RRL++ A+ + +
Sbjct: 1859 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1918
Query: 484 EGAVQLLESTLDSMQARVRELEEQCRSQTEQ 514
E + L DS R + L E Q Q
Sbjct: 1919 EERLAQLRKASDSELERQKGLVEDTLRQRRQ 1949
Score = 51.6 bits (122), Expect = 7e-06
Identities = 103/485 (21%), Positives = 194/485 (40%), Gaps = 70/485 (14%)
Query: 76 DPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQ 135
D E A C + +Q + EVE K +S E + AL E
Sbjct: 1039 DKEPARECAQRIAEQQKAQA---------EVEGLGKGVARLS----AEAEKVLALPEPSP 1085
Query: 136 RCAILKEENQM-LRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAP 194
L+ E ++ L K + + K K L + + E + E L+ A
Sbjct: 1086 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA- 1144
Query: 195 LPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQ 254
+P LE + +L + RA+ ++ + +D ++ Q LQ R E +
Sbjct: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRD-ELRGAQEVGERLQQRHGERDVEVER 1203
Query: 255 WLH-----VRDFDRLLRES---QREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGA 306
W + + +L ++ QRE+ +L RQ LR RE+ P G LQ
Sbjct: 1204 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQ--LRYYRESAD-----PLGAWLQ----- 1251
Query: 307 PAPGAPGEATPQEDADNLPVILGEPEKEQ--RVQQLESELSKKRKKCESLEQEARKKQRR 364
QE +P+ + +EQ + Q L E+ + +K E ++ A++
Sbjct: 1252 ------DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1305
Query: 365 CEELELQL----------------RQAQNENARLVEENSRLSGRATEKEQVEWENAELRG 408
++ ELQL + Q+ + +++E L +E + + +
Sbjct: 1306 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1365
Query: 409 QLLGVTQERDSALRKSQGLQ-SKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREK-Q 466
+ L +E + + + + +L +E L+ R++A+ Q + + E+ L+++ Q
Sbjct: 1366 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1425
Query: 467 EEVRRLQQAQAEAQRE----HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQEL 522
EEV R ++A +AQ++ E QL +S+ +QA+ R+ E RS+ + +E+
Sbjct: 1426 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR----IEEEI 1481
Query: 523 QAFRL 527
+ RL
Sbjct: 1482 RVVRL 1486
Score = 45.1 bits (105), Expect = 7e-04
Identities = 120/502 (23%), Positives = 203/502 (40%), Gaps = 86/502 (17%)
Query: 34 EPSSAAPSIADTPPAAL-QLQELRSEESSK-PKGDGSSRPVGGTDPEGAEACLPSLGQQA 91
EPS AAP++ L +L+++RS + K S + GT +GAE L + +Q
Sbjct: 1082 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQL 1139
Query: 92 SSSGPA-CQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKS 150
+ PE E +A LK + +P + LR ELR +E + L++
Sbjct: 1140 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR--DELRGA----QEVGERLQQR 1193
Query: 151 SFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALA 210
E + +V R + + A+L LE L +T++R L + G L R++
Sbjct: 1194 H-GERDVEVERWRERVAQL------LERWQAVLAQTDVR--QRELEQLGRQLRYYRESAD 1244
Query: 211 R-----QRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLL 265
Q AR E A+ D Q A++ + R+ QA L + + G + V + R
Sbjct: 1245 PLGAWLQDARRRQEQIQAMPLADSQ--AVREQLRQEQALLEEIERHGEK---VEECQRFA 1299
Query: 266 RESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLP 325
++ + + Q+ + L P P + ++G+ E+ QE D
Sbjct: 1300 KQYINAIKDYELQLVTYKAQ----LEPVASPAKKPKVQSGS-------ESVIQEYVD--- 1345
Query: 326 VILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEE 385
+ E Q +S+ ++ E E+E +Q+R EE E R A+ E A L ++
Sbjct: 1346 LRTHYSELTTLTSQYIKFISETLRRME--EEERLAEQQRAEERE---RLAEVE-AALEKQ 1399
Query: 386 NSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVA 445
A K Q E E EL+ + M+E
Sbjct: 1400 RQLAEAHAQAKAQAEREAKELQ-------------------------------QRMQEEV 1428
Query: 446 QRRQQLEVEHEQARLSLREKQEEVRRLQQ-AQAEAQREHEGAVQLLESTLDSMQARVREL 504
RR++ V+ +Q + S+ QEE+++L+Q ++AE Q + A S L ++ +R +
Sbjct: 1429 VRREEAAVDAQQQKRSI---QEELQQLRQSSEAEIQAKARQAEAAERSRL-RIEEEIRVV 1484
Query: 505 EEQCRSQTEQFSLLAQELQAFR 526
Q + Q ELQA R
Sbjct: 1485 RLQLEATERQRGGAEGELQALR 1506
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 73.2 bits (178), Expect = 2e-12
Identities = 112/448 (25%), Positives = 186/448 (41%), Gaps = 66/448 (14%)
Query: 124 LELLRALGELRQRCAILKEENQMLRKS-------------SFPETEEKVRRLKRKNAELA 170
L L RAL E ++ A L+ N+ R S E E+ R L+++ E+
Sbjct: 1479 LSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK 1538
Query: 171 VIAKRLE------ERARKLQETNLRVVSAPLPRPGTSLELCRKALARQRARDLSETASAL 224
+ LE E A+ E NL+ + A R + + +Q R + E + L
Sbjct: 1539 TQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL 1598
Query: 225 LAKDKQ----IAA---LQRECRELQARLTLVGKEGPQWL-HVRDFDRLLRESQREV--LR 274
+ KQ +AA L+ + ++L+A + K + + +R +++ RE+ R
Sbjct: 1599 EDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTR 1658
Query: 275 LQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQED--ADNLPVILGE-- 330
R+ L +E S A A A +A + D AD + G+
Sbjct: 1659 ASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA 1718
Query: 331 ---PEK---EQRVQQLESELSKKRKKCESLEQEARKKQRRCEE----LELQLRQAQ-NEN 379
EK E R+ QLE EL +++ E + +K + ++ L L+ AQ NEN
Sbjct: 1719 LALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNEN 1778
Query: 380 AR--LVEENSRLSGRATEKE------------QVEWENAELRGQLLGVTQERDSALRKSQ 425
AR L +N L + E E +E + A+L QL T+ER +A ++ +
Sbjct: 1779 ARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVR 1838
Query: 426 GLQSKLES-LEQVLKHMREVAQRRQQLE---VEHEQARLSLREKQEEVRRLQQAQAEAQR 481
+ KL+ L QV R Q + Q + +Q + L E +EE +R ++ + QR
Sbjct: 1839 RTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQR 1898
Query: 482 EHEGAVQLLESTLDSMQARVRELEEQCR 509
E E A + T D+M V L+ + R
Sbjct: 1899 ELEDATE----TADAMNREVSSLKNKLR 1922
Score = 62.4 bits (150), Expect = 4e-09
Identities = 86/415 (20%), Positives = 172/415 (41%), Gaps = 55/415 (13%)
Query: 141 KEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGT 200
+EE M ++ + EK + + E+ + +L +LQE +
Sbjct: 843 QEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQE-----------QLQA 891
Query: 201 SLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLT--------LVGKEG 252
ELC +A E + L AK ++ L+ C +L+AR+ L ++
Sbjct: 892 ETELCAEA---------EELRARLTAKKQE---LEEICHDLEARVEEEEERCQHLQAEKK 939
Query: 253 PQWLHVRDFDRLLRE--SQREVLRLQR-------------QIALRNQRETLPLPPSWPPG 297
++++ + L E S R+ L+L++ QI L +Q L
Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLED 999
Query: 298 PALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCES---- 353
+ ++ + + +I E+ +R ++ EL K R+K E
Sbjct: 1000 RIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTD 1059
Query: 354 LEQEARKKQRRCEELELQLRQAQNEN----ARLVEENSRLSGRATEKEQVEWENAELRGQ 409
L + + Q + EL++QL + + E AR+ EE ++ + + ++E + +EL+
Sbjct: 1060 LSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQED 1119
Query: 410 LLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEV 469
L R+ A ++ + L +LE+L+ L+ + +Q+L + EQ L++ EE
Sbjct: 1120 LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE 1179
Query: 470 RRLQQAQAEAQRE-HEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQ 523
+ +AQ + R+ H AV+ L L+ + LE+ ++ + LA E++
Sbjct: 1180 AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVK 1234
Score = 58.2 bits (139), Expect = 8e-08
Identities = 105/421 (24%), Positives = 175/421 (41%), Gaps = 82/421 (19%)
Query: 135 QRCAILKEENQMLRK-----SSFPETEEKVRRL-KRKNAELAVIAKRLEERARKLQETNL 188
Q C + KE+ + + ++ E EEK + L K KN A+I LEER R+ ++
Sbjct: 986 QNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITD-LEERLRREEKQR- 1043
Query: 189 RVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAA-LQRECRELQARLTL 247
LE R+ L + DLS+ + L A+ ++ L ++ ELQA L
Sbjct: 1044 -----------QELEKTRRKLEGD-STDLSDQIAELQAQIAELKMQLAKKEEELQAALAR 1091
Query: 248 VGKEGPQ----WLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQAR 303
V +E Q +R+ + + E Q + L+ + A RN+ E Q R
Sbjct: 1092 VEEEAAQKNMALKKIRELESQISELQED---LESERASRNKAEK-------------QKR 1135
Query: 304 AGAPAPGAPGEATPQEDADNLPVILGEPE----KEQRVQQLESELSKKRKKCESLEQEAR 359
G EA E D L + E +EQ V L+ L ++ K E+ QE R
Sbjct: 1136 D----LGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMR 1191
Query: 360 KKQRRC-EELELQLRQAQN-----ENARLVEENSR----------LSGRAT---EKEQVE 400
+K + EEL QL Q + E A+ EN R L G+ ++++VE
Sbjct: 1192 QKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVE 1251
Query: 401 WENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKH--------------MREVAQ 446
+ EL+ + + R K LQ +L+++ +L + Q
Sbjct: 1252 AQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQ 1311
Query: 447 RRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEE 506
Q+L E + +LSL K ++V + + E E E A LE + ++ A+V ++++
Sbjct: 1312 DTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKK 1371
Query: 507 Q 507
+
Sbjct: 1372 K 1372
Score = 57.4 bits (137), Expect = 1e-07
Identities = 88/397 (22%), Positives = 176/397 (44%), Gaps = 43/397 (10%)
Query: 154 ETEEKVRRLKRKNAELAVIAKRLEERAR---KLQETNLRVVSAPLPRPGTSLELCRKALA 210
ET E+V+R +K+ E +++R EE+ KL++T R+ L L+ R++
Sbjct: 1381 ETAEEVKRKLQKDLE--GLSQRHEEKVAAYDKLEKTKTRL-QQELDDLLVDLDHQRQSAC 1437
Query: 211 RQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQR 270
+ + LLA++K I+A E R+ +A KE R + + E +
Sbjct: 1438 NLEKKQ--KKFDQLLAEEKTISAKYAEERD-RAEAEAREKETKALSLARALEEAM-EQKA 1493
Query: 271 EVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGE 330
E+ RL +Q R + E L + G ++ + + ++ + + L E
Sbjct: 1494 ELERLNKQF--RTEMEDL-MSSKDDVGKSVHELEKS-------KRALEQQVEEMKTQLEE 1543
Query: 331 PEKEQRVQQ---LESELSKKRKKCESLEQEARKKQRRCEELELQL-RQAQNENARLVEEN 386
E E + + L E++ + K + E++ + + + EE + QL RQ + A L +E
Sbjct: 1544 LEDELQATEDAKLRLEVNLQAMKAQ-FERDLQGRDEQSEEKKKQLVRQVREMEAELEDER 1602
Query: 387 SRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLE-----------SLE 435
+ S ++++E + +L + + RD A+++ + LQ++++ S E
Sbjct: 1603 KQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE 1662
Query: 436 QVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAE-----AQREHEGAVQLL 490
++L +E ++ + +E E Q + L + R+ QQ + E A +GA+ L
Sbjct: 1663 EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALE 1722
Query: 491 ESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRL 527
E ++AR+ +LEE+ + L+ L+ L
Sbjct: 1723 EKR--RLEARIAQLEEELEEEQGNTELINDRLKKANL 1757
Score = 44.7 bits (104), Expect = 9e-04
Identities = 101/426 (23%), Positives = 176/426 (41%), Gaps = 58/426 (13%)
Query: 100 RPEDEEVEAFLKAKLNMSFGDRPNL-----ELLRALGELRQRCAILKEENQMLRKSSFPE 154
R E+++ + K + + GD +L EL + EL+ + A +EE Q E
Sbjct: 1037 RREEKQRQELEKTRRKLE-GDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEE 1095
Query: 155 TEEK---VRRLKRKNAELAVIAKRLE-ERA-RKLQETNLRVVSAPLPRPGTSLE-LCRKA 208
+K +++++ ++++ + + LE ERA R E R + L T LE
Sbjct: 1096 AAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDST 1155
Query: 209 LARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRES 268
A+Q R E +L K L+ E + +A++ + ++ Q V + L ++
Sbjct: 1156 AAQQELRSKREQEVNILKK-----TLEEEAKTHEAQIQEMRQKHSQ--AVEELAEQLEQT 1208
Query: 269 QREVLRLQR-QIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVI 327
+R L++ + L N+R L LQ + + EA QE L V
Sbjct: 1209 KRVKANLEKAKQTLENERGELANEVK----VLLQGKGDSEHKRKKVEAQLQE----LQVK 1260
Query: 328 LGEPEKEQ-----RVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARL 382
E E+ + +V +L+ EL + ++ K + LE QL+ Q L
Sbjct: 1261 FNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQE---LL 1317
Query: 383 VEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMR 442
EEN + +T+ +QVE E R QL +E + A L+ ++ +L
Sbjct: 1318 QEENRQKLSLSTKLKQVEDEKNSFREQL----EEEEEA---KHNLEKQIATLH------A 1364
Query: 443 EVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAE--AQREHE--GAVQLLESTLDSMQ 498
+VA ++++E + E EEV+R Q E +QR E A LE T +Q
Sbjct: 1365 QVADMKKKME-----DSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQ 1419
Query: 499 ARVREL 504
+ +L
Sbjct: 1420 QELDDL 1425
Score = 34.3 bits (77), Expect = 1.2
Identities = 25/105 (23%), Positives = 46/105 (43%), Gaps = 3/105 (2%)
Query: 422 RKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQR 481
R+ + + +K E L +V + R ++E Q + QE+++ + AEA+
Sbjct: 842 RQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEE 901
Query: 482 ---EHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQ 523
Q LE ++ARV E EE+C+ + + Q +Q
Sbjct: 902 LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 72.8 bits (177), Expect = 3e-12
Identities = 136/582 (23%), Positives = 236/582 (40%), Gaps = 95/582 (16%)
Query: 142 EENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTS 201
EE Q + + E ++K+RRL ++L K ++ + K E + ++S L +
Sbjct: 961 EELQQEARKAITEQKQKMRRL---GSDLTSAQKEMKTK-HKAYENAVGILSRRLQEALAA 1016
Query: 202 LELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDF 261
E L + RA+ S +S LA ++I AL+ E + + TL+ KE + + +
Sbjct: 1017 KEAADAELGQLRAQGGSSDSS--LALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQ 1074
Query: 262 DRLLRESQREVLRLQRQIA-----------LRNQRETLPLPPSWPPGPAL---QARAGAP 307
+ L ES+ +VL L+ ++ L + L L G Q+ A
Sbjct: 1075 E--LEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALR 1132
Query: 308 APGAPGE-ATPQEDAD----NLPV--ILGEPEKEQR-----VQQLESELSKKRKKCESLE 355
+ E A + +AD NL V +L E+E R VQ L++ L K+++K SL+
Sbjct: 1133 EHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLK 1192
Query: 356 Q-------EARKKQRRCEELELQLRQAQNE-----------NARLVEENSRLSGRATEKE 397
+ EA +R + L+L + + E A + R + E
Sbjct: 1193 EQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIA 1252
Query: 398 QVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLE-QVLKHMREVAQRRQQLEVEHE 456
Q + E AE R QL + ++ D L K ++E+L+ +V + RE+ +QQL++ +
Sbjct: 1253 QFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQ 1312
Query: 457 QARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFS 516
Q R L Q+ ++ ++ AQ + + + + +QA+V EL+ ++ +Q
Sbjct: 1313 QGRKELEGLQQLLQNVKSELEMAQED----LSMTQKDKFMLQAKVSELKNNMKTLLQQNQ 1368
Query: 517 LLAQELQ--AFRLHPGPLDLLTSALDCG--SLGDCPPPPCCCSIPQPCRGSGPKDLDLPP 572
L +L+ A + P +S+ + DCP P S ++L PP
Sbjct: 1369 QLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVP-----------ASLLEELLRPP 1417
Query: 573 GSPGRCTPKSSEPAPATLTGVPRRTAKKAESLSN--SSHSESIHNSPKSCPTPEVDTASE 630
P S+ L ++ ++ +SL H+ ++H S S E TAS
Sbjct: 1418 -------PAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHALTVHESLSSWTPLEPATASP 1470
Query: 631 VEELEADSVSLLPAAPEGSRGGARIQVFLARYSYNPFEGPNE 672
V P G G R S EGP E
Sbjct: 1471 V--------------PPGGHAGPRGDPQRHSQSRASKEGPGE 1498
Score = 61.2 bits (147), Expect = 9e-09
Identities = 95/407 (23%), Positives = 170/407 (41%), Gaps = 50/407 (12%)
Query: 140 LKEENQMLRKSSFPETEEKVRRLKRKNAELAVI----AKRLEERARKLQETNLR-VVSAP 194
LK EN L + TE + R +K K A + A L++ A +Q + +V
Sbjct: 613 LKLENVSLSQQL---TETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEED 669
Query: 195 LPRPGTSLELCRKALARQR------ARDLSETASALLAKDKQIAALQRECRELQARLTLV 248
L R E R+ L R + L + LL +D+Q+ ALQ+E +L +LTL
Sbjct: 670 LQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLT 729
Query: 249 GKEGPQ---------WLHVRDFDRLLRESQREVLRLQRQIAL-RNQRETLPLPPSWPPGP 298
+E Q H + L E Q E + I L +N++ L
Sbjct: 730 -QEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSG 788
Query: 299 ALQARAGAPAPGAPGEATPQ---EDADNLPVILGEPEKEQR--------VQQLESELSKK 347
+ GA E T + + + L + G+ E Q+ +Q+++ + ++
Sbjct: 789 KEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQ 848
Query: 348 RKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSG--RATEKE-------- 397
+ E+ ++A K + EL+ ++ +E L +E ++ G R E E
Sbjct: 849 KVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREV 908
Query: 398 -QVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHE 456
QV A+L G L +ERD Q LQ E + V + + ++Q+E +
Sbjct: 909 AQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEAL---KKQIEELQQ 965
Query: 457 QARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRE 503
+AR ++ E+++++RRL AQ+E + + E+ + + R++E
Sbjct: 966 EARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQE 1012
Score = 53.5 bits (127), Expect = 2e-06
Identities = 49/195 (25%), Positives = 88/195 (45%), Gaps = 29/195 (14%)
Query: 353 SLEQEARKKQRRCEELELQLRQAQNENARLVE----ENSRLSGRATEKE----------- 397
+L QEAR R + ++ Q A L+E EN LS + TE +
Sbjct: 583 ALAQEARV---RLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIA 639
Query: 398 -QVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHE 456
Q++ A++ Q Q +++ + LQ +LE E + ++ +A LE + E
Sbjct: 640 AQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLE 699
Query: 457 QARLSLREKQEEVRRLQQAQA----------EAQREHEGAVQLLESTLDSMQARVRELEE 506
Q +L+L ++ +++ LQQ EA + E ++ L++ D +QAR+ EL+
Sbjct: 700 QVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQG 759
Query: 507 QCRSQTEQFSLLAQE 521
+ S+ + LL E
Sbjct: 760 EAASREDTICLLQNE 774
Score = 33.9 bits (76), Expect = 1.5
Identities = 34/132 (25%), Positives = 60/132 (45%), Gaps = 16/132 (12%)
Query: 393 ATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLE 452
A ++Q + N E+R + RDS S E+ E++L+ ++E + QLE
Sbjct: 370 AEHQDQGQEVNGEVRSR-------RDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLE 422
Query: 453 VEHEQARLSLREKQEEVRRLQ------QAQAEAQREHEGAVQLLESTLDSMQARVRELEE 506
+A +L+EK E +L QAQ E + L S +D+++ +LE
Sbjct: 423 ALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLE- 481
Query: 507 QCRSQTEQFSLL 518
R+ T+ ++L
Sbjct: 482 --RAMTDLQNML 491
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 72.4 bits (176), Expect = 4e-12
Identities = 88/387 (22%), Positives = 165/387 (42%), Gaps = 67/387 (17%)
Query: 154 ETEEKVRRLKRKNAELAVIAKRLEER----ARKLQETNLRVVSAPLPRPGTSLELCRKAL 209
+ EE++ RLKR +E + K+LEE R L+E +++ + S+ R
Sbjct: 1572 KVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSED 1631
Query: 210 ARQRARDLSETASALLAKDKQIAALQRECRELQA--RLTLVGKEGPQWLHVR-------- 259
++ RD+ + L K + L+R E++A R L +E + H+R
Sbjct: 1632 DLRQQRDVLD--GHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAI 1689
Query: 260 -DFDRLLRESQREVLRLQ--------RQIALRNQRETLPLPPSWPPGPALQARAGAPAPG 310
D R L ES+ E+ RLQ + L + L L R G
Sbjct: 1690 EDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYD-------DLRRGRSEAD 1742
Query: 311 APGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELEL 370
+ AT E L + R +L+ ++ +++ E+L QE K Q++ E
Sbjct: 1743 SDKNATILELRSQLQI------SNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASN 1796
Query: 371 QLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSK 430
++++++N+ ++V+E L + EQ D A + Q L+ +
Sbjct: 1797 RIQESKNQCTQVVQERESLLVKIKVLEQ-------------------DKA--RLQRLEDE 1835
Query: 431 LESLEQVLKHMREVAQR----RQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGA 486
L + L+ V QR +QQ++ + Q + K+E +R+++ + +++RE
Sbjct: 1836 LNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS- 1894
Query: 487 VQLLESTLDSMQARVRELEEQCRSQTE 513
L S ++ +QA ++ +EE+CR + E
Sbjct: 1895 ---LRSEIERLQAEIKRIEERCRRKLE 1918
Score = 51.6 bits (122), Expect = 7e-06
Identities = 100/463 (21%), Positives = 186/463 (40%), Gaps = 97/463 (20%)
Query: 142 EENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLE-------ERARKLQETNL--RVVS 192
+E M ++ ++ RL R+N +L RL E+ R+ +E L +
Sbjct: 1222 KEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACG 1281
Query: 193 APLPRPGTSLELCRKALARQRARD-------LSETASALLAKDKQIAALQRECRELQARL 245
+ + + LE+ K + +QR+ D L E A + K+K+I L+ E +E R
Sbjct: 1282 SEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKR- 1340
Query: 246 TLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRET-LPLPPSWPPGPALQARA 304
+W + + ++ E+ I+L+NQ ET + + + +Q
Sbjct: 1341 --------RWEYENELSKVRNNYDEEI------ISLKNQFETEINITKTTIHQLTMQKEE 1386
Query: 305 GAPAPGAPGEATPQED-----------------ADNLPVILGEPEKE--------QRVQQ 339
A + +E+ +NL + + +++ QR QQ
Sbjct: 1387 DTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQ 1446
Query: 340 LESELS-----------KKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSR 388
LE EL + ++ + + + K + E L+ + + N+ L +EN+R
Sbjct: 1447 LEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENAR 1506
Query: 389 L----------SGRATEK----EQVEWENAELRGQLLGVTQER---DSALRKSQG----L 427
L + ATE + E E LR V+QER D + + Q L
Sbjct: 1507 LQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKEL 1566
Query: 428 QSKLESLEQVLKHMREVAQ----RRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREH 483
Q + + +E+ L ++ A +R++LE E E R SL+E+ ++ L Q +A
Sbjct: 1567 QLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVK 1626
Query: 484 EGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR 526
+ + L D + +RE + R+Q E+ L+ E++A R
Sbjct: 1627 KRSEDDLRQQRDVLDGHLREKQ---RTQ-EELRRLSSEVEALR 1665
Score = 47.8 bits (112), Expect = 1e-04
Identities = 51/215 (23%), Positives = 90/215 (41%), Gaps = 21/215 (9%)
Query: 332 EKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSR--- 388
E+ R+++ SE S KRKK E E E ++ + + +++ Q E A +V++ S
Sbjct: 1575 EELNRLKRTASEDSCKRKKLEE-ELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDL 1633
Query: 389 ------LSGRATEKEQVEWENAEL-------RGQLLGVTQERDSALRKSQGLQSKLESLE 435
L G EK++ + E L R QLL + A +++ Q +E
Sbjct: 1634 RQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKS 1693
Query: 436 QVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRR----LQQAQAEAQREHEGAVQLLE 491
+ L + +R Q L + L L E+ +R L++ ++EA + + L
Sbjct: 1694 RSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELR 1753
Query: 492 STLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR 526
S L R EL+ + L QE++ F+
Sbjct: 1754 SQLQISNNRTLELQGLINDLQRERENLRQEIEKFQ 1788
Score = 34.3 bits (77), Expect = 1.2
Identities = 27/111 (24%), Positives = 55/111 (49%), Gaps = 13/111 (11%)
Query: 333 KEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGR 392
KE+ ++++ESE K ++ SL E + Q + +E + R+ ++ R E S+L
Sbjct: 1874 KEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTR--ETQSQLE-- 1929
Query: 393 ATEKEQVEWENAELRGQLLGVTQER--------DSALRKSQGLQSKLESLE 435
TE+ + + E +LR + G +E D++ GL+ K+ +++
Sbjct: 1930 -TERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQ 1979
Score = 31.2 bits (69), Expect = 9.8
Identities = 38/190 (20%), Positives = 76/190 (40%), Gaps = 30/190 (15%)
Query: 338 QQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKE 397
+ L SE+S KR K E +++ A ++ ELQL + L+ + + +
Sbjct: 931 KNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSG 990
Query: 398 QVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQ 457
+ E A++ + + + R L ++LK + ++ + ++EV E+
Sbjct: 991 VILQEAADVHARYIELLTRSGDYYR----------FLSEMLKSLEDLKLKNTKIEVLEEE 1040
Query: 458 ARLSLREKQEEVRR-------LQQAQAEA-------------QREHEGAVQLLESTLDSM 497
RL+ E + LQ+ QAE +R+ E + + LD
Sbjct: 1041 LRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKC 1100
Query: 498 QARVRELEEQ 507
+++EL E+
Sbjct: 1101 YGQIKELNEK 1110
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 71.2 bits (173), Expect = 9e-12
Identities = 93/438 (21%), Positives = 179/438 (40%), Gaps = 32/438 (7%)
Query: 90 QASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLEL----LRALGELRQRCAILKEENQ 145
+ ++SG C PEDE+ KA R LE +R L + + +Q
Sbjct: 85 ETTTSG-GCHSPEDEQ-----KASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQ 138
Query: 146 MLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELC 205
K E + + RL + + L A + ++ + + R SLEL
Sbjct: 139 HAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELY 198
Query: 206 RKALARQRARDLS-ETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRL 264
R + + ++ + + L + + + +Q +EL+ +L PQ + D L
Sbjct: 199 RNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL 258
Query: 265 LRESQREVLRLQRQIA---LRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDA 321
+E Q +LQ Q+ L N+ W +Q R E QE
Sbjct: 259 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQER----------EEKIQEQE 308
Query: 322 DNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEE-LELQLRQAQNENA 380
+ I + EK +R +++ E +K ++ E + E +K R EE + Q + + E
Sbjct: 309 EK---IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 365
Query: 381 RLVEENSRLSGRATEKEQVEWENAE-LRGQLLGVTQERDSALRKSQGLQSKLESLEQVLK 439
R EE R + E+E W E +R Q + ++ + + + + + E + + +
Sbjct: 366 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEE 425
Query: 440 HMREVAQRRQQLEVEHEQARLSLREKQEEVRR---LQQAQAEAQREHEGAVQLLESTLDS 496
M+E ++ ++ E + + +RE++E++R + Q Q E E EG + E+ +
Sbjct: 426 EMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQE 485
Query: 497 MQARVRELEEQCRSQTEQ 514
+ ++R EE+ R Q ++
Sbjct: 486 QEEKMRRQEEKIREQEKK 503
Score = 63.9 bits (154), Expect = 1e-09
Identities = 91/428 (21%), Positives = 191/428 (44%), Gaps = 36/428 (8%)
Query: 89 QQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRAL---GELRQRCAILKEENQ 145
+QA S+ ++ D +E K + D +LEL R EL+++ A L+E+ Q
Sbjct: 166 EQALSAVATQKKKADRYIEELTKER------DALSLELYRNTITDEELKEKNAKLQEKLQ 219
Query: 146 MLRKSSFPETEEKVRRLKRK--NAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLE 203
++ +S E + V+ LKRK A+L + ++L+ A L + L+ VSA L E
Sbjct: 220 LV-ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGK-ELQSVSAKLQAQVEENE 277
Query: 204 LCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLH---VRD 260
L + L +Q+ + + ++++I + + RE + ++ +E W +R
Sbjct: 278 LWNR-LNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRR--QEEMMWEKEEKMRR 334
Query: 261 FDRLLRESQREVLRLQRQIALRNQ-RETLPLPPSWPPGPALQARAGAPAPGAPGEATPQE 319
+ ++ E + ++ L+ ++ + + RE + R A E +E
Sbjct: 335 QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 394
Query: 320 DADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNEN 379
+ + E+E+ +Q+ E ++ ++ +K E+E ++++ + E ++R+ Q +
Sbjct: 395 QEEKIR------EQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIRE-QEKK 447
Query: 380 ARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLK 439
R EE R E+E++ E E G+ G E+++ K Q + K+ E+ ++
Sbjct: 448 IREQEEKIR------EQEEMMQEQEEKMGEQEGKMCEQEA---KMQEQEEKMRRQEEKIR 498
Query: 440 HMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQA 499
+ + +++ E E+ EK E Q E +E E ++ E + +
Sbjct: 499 EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEV 558
Query: 500 RVRELEEQ 507
R+R+ EE+
Sbjct: 559 RLRQQEEK 566
Score = 43.1 bits (100), Expect = 0.003
Identities = 62/315 (19%), Positives = 123/315 (39%), Gaps = 23/315 (7%)
Query: 132 ELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVV 191
EL R +EE ++ E EEK++ + K E +R EE + +E R
Sbjct: 277 ELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQE 336
Query: 192 SAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKE 251
+ EL K +++ R+ E + + RE + R K
Sbjct: 337 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQE-----------EEKIREQEKRQEQEAKM 385
Query: 252 GPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGA 311
Q +R+ + +RE Q E+++ Q + + + R
Sbjct: 386 WRQEEKIREQEEKIRE-QEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQ 444
Query: 312 PGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQ 371
+ QE+ + + E+E+++ + E ++ ++ K + E++ R+++ + E E +
Sbjct: 445 EKKIREQEEKIREQEEMMQ-EQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKK 503
Query: 372 LRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKL 431
+R+ Q E R EE + E+E+ WE E + QE++ +R+ + K+
Sbjct: 504 IRE-QEEKIREQEEMMQ------EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ---EEKM 553
Query: 432 ESLEQVLKHMREVAQ 446
E L+ E Q
Sbjct: 554 REQEVRLRQQEEKMQ 568
Score = 32.0 bits (71), Expect = 5.8
Identities = 26/92 (28%), Positives = 47/92 (51%), Gaps = 10/92 (10%)
Query: 1263 EEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCE-----TDSDEEILEQIL 1317
E+EE +E+EE++G + +Q A +E + Q + E + +E+I EQ
Sbjct: 457 EQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ-- 514
Query: 1318 ELPLQQFCSKKLFSIPEE--EEEEEEDEEEEK 1347
+ Q +K++ E+ E+EE+ E+EEK
Sbjct: 515 -EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 545
Score = 31.2 bits (69), Expect = 9.8
Identities = 22/86 (25%), Positives = 43/86 (50%), Gaps = 6/86 (6%)
Query: 1262 EEEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELPL 1321
+E EE+ +E+EE++ + ++Q +E + Q + E + E+I EL
Sbjct: 298 QEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE------EKIRELEE 351
Query: 1322 QQFCSKKLFSIPEEEEEEEEDEEEEK 1347
+ +K+ E+ +EEE+ E+EK
Sbjct: 352 KMHEQEKIREQEEKRQEEEKIREQEK 377
>gi|157042792 coiled-coil domain containing 64B [Homo sapiens]
Length = 508
Score = 70.9 bits (172), Expect = 1e-11
Identities = 100/329 (30%), Positives = 139/329 (42%), Gaps = 50/329 (15%)
Query: 256 LHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQA----RAGAPAPGA 311
L ++ D LL ++L L+R LR Q ETL Q R G A GA
Sbjct: 54 LQQKEKDLLLAAELGKML-LERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGA 112
Query: 312 PGEATPQE---DADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEEL 368
EA E D + L LGE QR +Q +S + R E EQ R Q
Sbjct: 113 EWEARAVELEGDVEALRAQLGE----QRSEQQDSGRERARALSELSEQNLRLSQ------ 162
Query: 369 ELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQ 428
QL QA L E L G+ + AELR +L +S ++Q LQ
Sbjct: 163 --QLAQASQTEQELQRELDALRGQCQAQALA---GAELRTRL-------ESLQGENQMLQ 210
Query: 429 SKLESLEQVLKHMREVAQRRQ-QLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAV 487
S+ + LE ++ +RE ++ + +L+ HE+ L RE++E L++A++EA
Sbjct: 211 SRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGE------ 264
Query: 488 QLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALDCGSLGDC 547
S L +Q RV ELEE+ R Q S A LQ+ H LD + GD
Sbjct: 265 --ALSALRRLQRRVSELEEESRLQDADVS--AASLQSELAH--SLDDGDQGQGADAPGDT 318
Query: 548 P----PPPCCCSIPQPCRGSGPKDLDLPP 572
P P S PQP S P+++ PP
Sbjct: 319 PTTRSPKTRKASSPQP---SPPEEILEPP 344
Score = 55.1 bits (131), Expect = 6e-07
Identities = 95/392 (24%), Positives = 164/392 (41%), Gaps = 66/392 (16%)
Query: 81 EACLPSLGQQASS---SGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRC 137
EA LG+Q S SG R E E L+ ++ + EL R L LR +C
Sbjct: 126 EALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQC 185
Query: 138 ---AILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAP 194
A+ E + +S E + R + A++ + + +E+ +LQ T+ ++
Sbjct: 186 QAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLR 245
Query: 195 LPRPGTSLELCRKALARQRAR-DLSETASALLAKDKQIAALQRECRELQARLTLVGKEGP 253
R SLEL +RAR + E SAL ++++ L+ E R
Sbjct: 246 RERREHSLEL-------ERARSEAGEALSALRRLQRRVSELEEESR-------------- 284
Query: 254 QWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQAR-AGAPAPGAP 312
++D D Q E L + +Q + P P + + R A +P P P
Sbjct: 285 ----LQDADVSAASLQSE---LAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPP 337
Query: 313 GEAT--PQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQE-ARKKQRRCEELE 369
E P++ P + E EKE V +L+ E+S ++ + +SL +E R+K+ R +E
Sbjct: 338 EEILEPPKKRTSLSPAEILE-EKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQE-- 394
Query: 370 LQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDS-------ALR 422
+ L +++++ + EL QL V+ ERDS A+R
Sbjct: 395 --------------DPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIR 440
Query: 423 KSQGLQSKLESLE---QVLKHMREVAQRRQQL 451
+ L +LE+ + QV+ + +QR+++L
Sbjct: 441 QKVALTQELEAWQDDMQVVIGQQLRSQRQKEL 472
Score = 49.7 bits (117), Expect = 3e-05
Identities = 66/245 (26%), Positives = 100/245 (40%), Gaps = 41/245 (16%)
Query: 289 PLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVIL--------GEPEKEQRVQQL 340
P PS+P GP G A+P D P +L G P E+ + L
Sbjct: 4 PDGPSFPSGPL------------SGGASPSGDEGFFPFVLERRDSFLGGGPGPEEP-EDL 50
Query: 341 ESELSKKRKKCESLEQEARKKQRRCEELELQLR----QAQNENARLVEENSRLSGRATEK 396
+L +K K + + R EEL QL Q RL +EN L R
Sbjct: 51 ALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELR-RGLAA 109
Query: 397 EQVEWEN--AELRGQLLGVTQERDSALRKSQGLQ--SKLESLEQVLKHMREVAQRRQQLE 452
EWE EL G + ALR G Q + +S + + + E++++ +L
Sbjct: 110 RGAEWEARAVELEGDV--------EALRAQLGEQRSEQQDSGRERARALSELSEQNLRLS 161
Query: 453 VEHEQARLSLREKQEEVRRLQ---QAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCR 509
+ QA + +E Q E+ L+ QAQA A E ++ L+ +Q+R ++LE Q R
Sbjct: 162 QQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIR 221
Query: 510 SQTEQ 514
E+
Sbjct: 222 GLREE 226
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 69.7 bits (169), Expect = 2e-11
Identities = 97/376 (25%), Positives = 133/376 (35%), Gaps = 96/376 (25%)
Query: 1057 VRTMSPHGESADSIPAPITPALAPA-----------------SLPARVSCPSPHPSPEAR 1099
V + P G + + PAP+ P AP+ S+P+ PS P P A
Sbjct: 635 VPPLQPMGPTCPT-PAPVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGPMPSAGPMPSA- 692
Query: 1100 APLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMAKGSHEDP------------ 1147
P+ SA PGP ++ L P PP P P A GS+EDP
Sbjct: 693 GPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPG-PENHRA-GSNEDPILAPSGTPPPTI 750
Query: 1148 ----------PAPC----SQEEAGAAVLGTSEERTASTSTLGE-------KDPGPAAPSL 1186
P P +EEA + + S + E P A P
Sbjct: 751 PPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPP 810
Query: 1187 AKQEAEWTAGEACPASSSTQGARAQQAP------------------NTEMCQGGDPGSGL 1228
TA PA + A P ++ G PG G
Sbjct: 811 IAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGG 870
Query: 1229 RPRAEKEDTAELGVHLVNSLVDHGRNSDLSDIQEEEEEEEEEEEEELGSRTCSFQKQVAG 1288
P E++ L V +NS SD +EEEEEEEEEEEEE F+++
Sbjct: 871 PPALEED----LTVININS----------SDEEEEEEEEEEEEEEEEEEEEEDFEEE--- 913
Query: 1289 NSIRENGAKSQPDPFCETDSDEEILEQILELPLQQFCSKKLFSIPEEEEEEEEDEEEEKS 1348
+ + + F E + +EE E+ E + ++ EEEEE EE E+ E
Sbjct: 914 -------EEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFG 966
Query: 1349 GAGCSSRDPGPPEPAL 1364
AG + PP P L
Sbjct: 967 TAGGEVEEGAPPPPTL 982
Score = 41.2 bits (95), Expect = 0.010
Identities = 34/127 (26%), Positives = 52/127 (40%), Gaps = 10/127 (7%)
Query: 289 PLPPSWPPGPALQARAGAPAP-----GAPGEATPQEDADNLPVIL-----GEPEKEQRVQ 338
PLPP PP P + P P G PG P ++L VI E E+E+ +
Sbjct: 838 PLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEE 897
Query: 339 QLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQ 398
+ E E ++ + E E++ + EE E + + E +EE E+E
Sbjct: 898 EEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEEL 957
Query: 399 VEWENAE 405
E E+ E
Sbjct: 958 EEVEDLE 964
Score = 39.3 bits (90), Expect = 0.036
Identities = 26/73 (35%), Positives = 35/73 (47%), Gaps = 2/73 (2%)
Query: 973 TLPAG--PPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYAIYADGQKIME 1030
TLP PP++P VQ EP P PG+L+ P T + G + A+ + G+ E
Sbjct: 981 TLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVERE 1040
Query: 1031 VASPTAGSVLVEL 1043
SP AG EL
Sbjct: 1041 GESPAAGPPPQEL 1053
Score = 35.4 bits (80), Expect = 0.52
Identities = 44/149 (29%), Positives = 51/149 (34%), Gaps = 33/149 (22%)
Query: 1064 GESADSIPAPIT--PALAPASLPARVSCPSPHPSP------------EAR--------AP 1101
GE + P P T PAL P P +V P P P P E R AP
Sbjct: 970 GEVEEGAPPPPTLPPALPPPESPPKVQ-PEPEPEPGLLLEVEEPGTEEERGADTAPTLAP 1028
Query: 1102 LASASPGP--GDPSSPLQHPAPLG-TQEPPGAPPASPSREMAKGSHEDPPAPCSQEEAGA 1158
A S G + SP P P +E P APP E GS + P P + E
Sbjct: 1029 EALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAE--- 1085
Query: 1159 AVLGTSEERTASTSTLGEKDPGPAAPSLA 1187
E L EK+ A LA
Sbjct: 1086 ----EEMETETEAEALQEKEQDDTAAMLA 1110
Score = 32.0 bits (71), Expect = 5.8
Identities = 37/173 (21%), Positives = 63/173 (36%), Gaps = 11/173 (6%)
Query: 452 EVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQ 511
E E E+ E++EE ++ + + + E + E + + ELEE+ +
Sbjct: 890 EEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEE 949
Query: 512 TEQFSLLAQELQAFRLHPGPLDLLTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLP 571
E+ +E++ L+ T+ G + + PPP P S PK P
Sbjct: 950 DEEEEEELEEVE-------DLEFGTAG---GEVEEGAPPPPTLPPALPPPESPPKVQPEP 999
Query: 572 PGSPGRCTPKSSEPAPATLTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPE 624
PG + EP G E+L + E SP + P P+
Sbjct: 1000 EPEPGLLL-EVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQ 1051
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 69.3 bits (168), Expect = 3e-11
Identities = 105/449 (23%), Positives = 176/449 (39%), Gaps = 71/449 (15%)
Query: 110 LKAKLNMSFGDRPNLELLRALGELRQR-----CAILKEENQMLRK-------------SS 151
L+A L G R L+L + E + + +L+++N L K S
Sbjct: 980 LEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQ 1039
Query: 152 FPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKAL-A 210
E EEKV+ L + + +E+R RK ++ + G S EL + +
Sbjct: 1040 AAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQ 1099
Query: 211 RQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQR 270
+QRA +L A L R+ ELQA L EG + + LRE+Q
Sbjct: 1100 QQRAEELR-------------AQLGRKEEELQAALARAEDEGGARAQLL---KSLREAQA 1143
Query: 271 EVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGE 330
+ Q + T G L+A G E D L +
Sbjct: 1144 ALAEAQEDLESERVARTKAEKQRRDLGEELEALRG-------------ELEDTLDSTNAQ 1190
Query: 331 PEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLS 390
E + +Q +EL K +LE+E R + +EL + QA E A +E+ R
Sbjct: 1191 QELRSKREQEVTELKK------TLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK 1244
Query: 391 GRATEKEQ--VEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLE----QVLKHMREV 444
G A EK + +E E +ELR +L + R ++ + L+ +L+ ++ + E
Sbjct: 1245 G-AWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEA 1303
Query: 445 AQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLE----------STL 494
A++ Q+ + E E +L E + + RL + + + + A +LL+ S +
Sbjct: 1304 AEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRV 1363
Query: 495 DSMQARVRELEEQCRSQTEQFSLLAQELQ 523
+M+A L EQ + +ELQ
Sbjct: 1364 RAMEAEAAGLREQLEEEAAARERAGRELQ 1392
Score = 65.5 bits (158), Expect = 5e-10
Identities = 121/472 (25%), Positives = 194/472 (41%), Gaps = 62/472 (13%)
Query: 100 RPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKV 159
R E E L+A+L + ++ +++ EL + C + ++ LR + E E+++
Sbjct: 1524 REELERQNRALRAELEALLSSKDDVG--KSVHELERACRVAEQAANDLR-AQVTELEDEL 1580
Query: 160 RRLKRKNAELAVIAKRL---------------EERARKL--QETNLRVVSAPLPRPGTSL 202
+ L V + L EER R+L Q + V + T
Sbjct: 1581 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLA 1640
Query: 203 ELCRKALARQRARDLSETASALLAKD---KQIAALQRECREL--QARLTLVGKEGPQWLH 257
RK L + ++ ASA K+ KQ+ +Q + +EL + T +E +
Sbjct: 1641 VAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSRE-EIFSQ 1699
Query: 258 VRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQAR---AGAPAPGAPGE 314
R+ ++ L+ + EVLRLQ ++A ++ A Q R A A G +
Sbjct: 1700 NRESEKRLKGLEAEVLRLQEELAASDRARR----------QAQQDRDEMADEVANGNLSK 1749
Query: 315 ATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKK-----CESLEQEA---RKKQRRCE 366
A E+ L LG+ E+E +Q SEL R + ESL E R + E
Sbjct: 1750 AAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAE 1809
Query: 367 ELELQL-RQAQNENARLVEENSRLSGRATEKEQV---EWENAELRGQLLGVTQERDSALR 422
QL RQ Q RL EE++ RA K + E + A+ QL T+ER + +
Sbjct: 1810 SGRQQLERQIQELRGRLGEEDA--GARARHKMTIAALESKLAQAEEQLEQETRERILSGK 1867
Query: 423 KSQGLQSKLESLEQVLKHMREVA-QRRQQLE---VEHEQARLSLREKQEEVRRLQQAQAE 478
+ + +L+ + ++ R VA Q R QLE + +Q + L E +EE R Q +
Sbjct: 1868 LVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRR 1927
Query: 479 AQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPG 530
QRE E + + +SM V L + R F+ Q FRL G
Sbjct: 1928 LQRELEDVTE----SAESMNREVTTLRNRLRRGPLTFTTRTVR-QVFRLEEG 1974
Score = 59.7 bits (143), Expect = 3e-08
Identities = 88/340 (25%), Positives = 143/340 (42%), Gaps = 61/340 (17%)
Query: 224 LLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIA-LR 282
L K K + + R+ LQAR + K L ++S REV LQ ++A L
Sbjct: 862 LFTKVKPLLQVTRQDEVLQARAQELQK----------VQELQQQSAREVGELQGRVAQLE 911
Query: 283 NQRETLPLPPSWPPGPALQARAGAPAPGAPGE------ATPQE---DADNLPVILGEPEK 333
+R L A Q RA A E A QE L +GE E+
Sbjct: 912 EERARL----------AEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEE 961
Query: 334 ------------EQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENAR 381
+Q +Q+LE+ L + + L+ E + + ++ E L +++N++
Sbjct: 962 CSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSK 1021
Query: 382 LVEENSRL-------SGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESL 434
L +E L S +A E+E+ +LR + + + LRK + + +LE L
Sbjct: 1022 LSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKL 1081
Query: 435 EQVLK-HMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLEST 493
++ L E+ ++ + + E+ R L K+EE LQ A A A+ E QLL+S
Sbjct: 1082 KRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEE---LQAALARAEDEGGARAQLLKS- 1137
Query: 494 LDSMQARVRELEEQCRSQ-------TEQFSLLAQELQAFR 526
L QA + E +E S+ +Q L +EL+A R
Sbjct: 1138 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALR 1177
Score = 59.7 bits (143), Expect = 3e-08
Identities = 97/403 (24%), Positives = 154/403 (38%), Gaps = 80/403 (19%)
Query: 128 RALGELRQRCAILKEENQMLRK------SSFPETEEKVRRLKRKNAELAVIAKRLEERAR 181
R +GEL+ R A L+EE L + E EE RL + EL ++ LE R
Sbjct: 898 REVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVG 957
Query: 182 KLQETNLRVVSAPLPRPGTSLELCRKALARQRAR---DLSETASALLAKDKQIAALQREC 238
+ +E C + + ++ R + E + L A++ LQ E
Sbjct: 958 EEEE-------------------CSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEK 998
Query: 239 RELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGP 298
+A++ + D LL E Q L +R++
Sbjct: 999 VTTEAKMKKF-----------EEDLLLLEDQNSKLSKERKL------------------- 1028
Query: 299 ALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEA 358
L+ R + A E + + L + + E + +E L K+ K QE
Sbjct: 1029 -LEDRLAEFSSQAAEEEEKVKSLNKLRL-----KYEATIADMEDRLRKEEKG----RQEL 1078
Query: 359 RKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAE----LRGQLLGVT 414
K +RR + +L++ E + EE GR E+ Q AE R QLL
Sbjct: 1079 EKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSL 1138
Query: 415 QERDSALRKSQ-GLQSKLESLEQVLKHMREVAQRRQQLEVEHE------QARLSLREKQE 467
+E +AL ++Q L+S+ + + K R++ + + L E E A+ LR K+E
Sbjct: 1139 REAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKRE 1198
Query: 468 -EVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCR 509
EV L++ E R HE AVQ L + E EQ R
Sbjct: 1199 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQAR 1241
Score = 53.9 bits (128), Expect = 1e-06
Identities = 103/466 (22%), Positives = 175/466 (37%), Gaps = 66/466 (14%)
Query: 104 EEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETE-EKVRRL 162
E+ L+A+++ + +L+ R GE R+R L+ + R E +L
Sbjct: 1248 EKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKL 1307
Query: 163 KRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALAR----QRARDLS 218
+R AEL ++ L E K + + S L + A+ R R +
Sbjct: 1308 QRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAME 1367
Query: 219 ETASALLAK-DKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQR 277
A+ L + +++ AA +R RELQ + +W R +E + L
Sbjct: 1368 AEAAGLREQLEEEAAARERAGRELQTAQAQLS----EW-------RRRQEEEAGALEAGE 1416
Query: 278 QIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRV 337
+ R RE L L + G Q++ D+ + L ++
Sbjct: 1417 EARRRAAREAEALTQR------LAEKTETVDRLERGRRRLQQELDDATMDL------EQQ 1464
Query: 338 QQLESELSKKRKKCESL-EQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEK 396
+QL S L KK++K + L +E R EE E + + AR + L +
Sbjct: 1465 RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAR 1524
Query: 397 EQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMR-------------E 443
E++E +N LR +L + +D + L+ EQ +R E
Sbjct: 1525 EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAE 1584
Query: 444 VAQRR-----QQLEVEHEQARLSLREKQEEVRR---LQQAQAEAQREHE--------GAV 487
A+ R Q L+ +HE+ E EE RR Q AE +R+ E A
Sbjct: 1585 DAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAAR 1644
Query: 488 QLLESTLDSMQARV-------RELEEQCRSQTEQFSLLAQELQAFR 526
+ LE L+ ++A++ E +Q R Q L +E++ R
Sbjct: 1645 KKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR 1690
Score = 35.8 bits (81), Expect = 0.40
Identities = 34/116 (29%), Positives = 57/116 (49%), Gaps = 15/116 (12%)
Query: 422 RKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ- 480
R+ + LQ++ + L++V +E+ Q++ EV Q R++ E +E R +Q +AEA+
Sbjct: 874 RQDEVLQARAQELQKV----QEL-QQQSAREVGELQGRVAQLE-EERARLAEQLRAEAEL 927
Query: 481 ----REHEGAV----QLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLH 528
E G + Q LE + ++ARV E EE R + L Q +Q H
Sbjct: 928 CAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAH 983
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 69.3 bits (168), Expect = 3e-11
Identities = 105/449 (23%), Positives = 176/449 (39%), Gaps = 71/449 (15%)
Query: 110 LKAKLNMSFGDRPNLELLRALGELRQR-----CAILKEENQMLRK-------------SS 151
L+A L G R L+L + E + + +L+++N L K S
Sbjct: 972 LEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQ 1031
Query: 152 FPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKAL-A 210
E EEKV+ L + + +E+R RK ++ + G S EL + +
Sbjct: 1032 AAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQ 1091
Query: 211 RQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQR 270
+QRA +L A L R+ ELQA L EG + + LRE+Q
Sbjct: 1092 QQRAEELR-------------AQLGRKEEELQAALARAEDEGGARAQLL---KSLREAQA 1135
Query: 271 EVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGE 330
+ Q + T G L+A G E D L +
Sbjct: 1136 ALAEAQEDLESERVARTKAEKQRRDLGEELEALRG-------------ELEDTLDSTNAQ 1182
Query: 331 PEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLS 390
E + +Q +EL K +LE+E R + +EL + QA E A +E+ R
Sbjct: 1183 QELRSKREQEVTELKK------TLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK 1236
Query: 391 GRATEKEQ--VEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLE----QVLKHMREV 444
G A EK + +E E +ELR +L + R ++ + L+ +L+ ++ + E
Sbjct: 1237 G-AWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEA 1295
Query: 445 AQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLE----------STL 494
A++ Q+ + E E +L E + + RL + + + + A +LL+ S +
Sbjct: 1296 AEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRV 1355
Query: 495 DSMQARVRELEEQCRSQTEQFSLLAQELQ 523
+M+A L EQ + +ELQ
Sbjct: 1356 RAMEAEAAGLREQLEEEAAARERAGRELQ 1384
Score = 65.5 bits (158), Expect = 5e-10
Identities = 121/472 (25%), Positives = 194/472 (41%), Gaps = 62/472 (13%)
Query: 100 RPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKV 159
R E E L+A+L + ++ +++ EL + C + ++ LR + E E+++
Sbjct: 1516 REELERQNRALRAELEALLSSKDDVG--KSVHELERACRVAEQAANDLR-AQVTELEDEL 1572
Query: 160 RRLKRKNAELAVIAKRL---------------EERARKL--QETNLRVVSAPLPRPGTSL 202
+ L V + L EER R+L Q + V + T
Sbjct: 1573 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLA 1632
Query: 203 ELCRKALARQRARDLSETASALLAKD---KQIAALQRECREL--QARLTLVGKEGPQWLH 257
RK L + ++ ASA K+ KQ+ +Q + +EL + T +E +
Sbjct: 1633 VAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSRE-EIFSQ 1691
Query: 258 VRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQAR---AGAPAPGAPGE 314
R+ ++ L+ + EVLRLQ ++A ++ A Q R A A G +
Sbjct: 1692 NRESEKRLKGLEAEVLRLQEELAASDRARR----------QAQQDRDEMADEVANGNLSK 1741
Query: 315 ATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKK-----CESLEQEA---RKKQRRCE 366
A E+ L LG+ E+E +Q SEL R + ESL E R + E
Sbjct: 1742 AAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAE 1801
Query: 367 ELELQL-RQAQNENARLVEENSRLSGRATEKEQV---EWENAELRGQLLGVTQERDSALR 422
QL RQ Q RL EE++ RA K + E + A+ QL T+ER + +
Sbjct: 1802 SGRQQLERQIQELRGRLGEEDA--GARARHKMTIAALESKLAQAEEQLEQETRERILSGK 1859
Query: 423 KSQGLQSKLESLEQVLKHMREVA-QRRQQLE---VEHEQARLSLREKQEEVRRLQQAQAE 478
+ + +L+ + ++ R VA Q R QLE + +Q + L E +EE R Q +
Sbjct: 1860 LVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRR 1919
Query: 479 AQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPG 530
QRE E + + +SM V L + R F+ Q FRL G
Sbjct: 1920 LQRELEDVTE----SAESMNREVTTLRNRLRRGPLTFTTRTVR-QVFRLEEG 1966
Score = 59.7 bits (143), Expect = 3e-08
Identities = 88/340 (25%), Positives = 143/340 (42%), Gaps = 61/340 (17%)
Query: 224 LLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIA-LR 282
L K K + + R+ LQAR + K L ++S REV LQ ++A L
Sbjct: 854 LFTKVKPLLQVTRQDEVLQARAQELQK----------VQELQQQSAREVGELQGRVAQLE 903
Query: 283 NQRETLPLPPSWPPGPALQARAGAPAPGAPGE------ATPQE---DADNLPVILGEPEK 333
+R L A Q RA A E A QE L +GE E+
Sbjct: 904 EERARL----------AEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEE 953
Query: 334 ------------EQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENAR 381
+Q +Q+LE+ L + + L+ E + + ++ E L +++N++
Sbjct: 954 CSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSK 1013
Query: 382 LVEENSRL-------SGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESL 434
L +E L S +A E+E+ +LR + + + LRK + + +LE L
Sbjct: 1014 LSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKL 1073
Query: 435 EQVLK-HMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLEST 493
++ L E+ ++ + + E+ R L K+EE LQ A A A+ E QLL+S
Sbjct: 1074 KRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEE---LQAALARAEDEGGARAQLLKS- 1129
Query: 494 LDSMQARVRELEEQCRSQ-------TEQFSLLAQELQAFR 526
L QA + E +E S+ +Q L +EL+A R
Sbjct: 1130 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALR 1169
Score = 59.7 bits (143), Expect = 3e-08
Identities = 97/403 (24%), Positives = 154/403 (38%), Gaps = 80/403 (19%)
Query: 128 RALGELRQRCAILKEENQMLRK------SSFPETEEKVRRLKRKNAELAVIAKRLEERAR 181
R +GEL+ R A L+EE L + E EE RL + EL ++ LE R
Sbjct: 890 REVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVG 949
Query: 182 KLQETNLRVVSAPLPRPGTSLELCRKALARQRAR---DLSETASALLAKDKQIAALQREC 238
+ +E C + + ++ R + E + L A++ LQ E
Sbjct: 950 EEEE-------------------CSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEK 990
Query: 239 RELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGP 298
+A++ + D LL E Q L +R++
Sbjct: 991 VTTEAKMKKF-----------EEDLLLLEDQNSKLSKERKL------------------- 1020
Query: 299 ALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEA 358
L+ R + A E + + L + + E + +E L K+ K QE
Sbjct: 1021 -LEDRLAEFSSQAAEEEEKVKSLNKLRL-----KYEATIADMEDRLRKEEKG----RQEL 1070
Query: 359 RKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAE----LRGQLLGVT 414
K +RR + +L++ E + EE GR E+ Q AE R QLL
Sbjct: 1071 EKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSL 1130
Query: 415 QERDSALRKSQ-GLQSKLESLEQVLKHMREVAQRRQQLEVEHE------QARLSLREKQE 467
+E +AL ++Q L+S+ + + K R++ + + L E E A+ LR K+E
Sbjct: 1131 REAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKRE 1190
Query: 468 -EVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCR 509
EV L++ E R HE AVQ L + E EQ R
Sbjct: 1191 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQAR 1233
Score = 53.9 bits (128), Expect = 1e-06
Identities = 103/466 (22%), Positives = 175/466 (37%), Gaps = 66/466 (14%)
Query: 104 EEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETE-EKVRRL 162
E+ L+A+++ + +L+ R GE R+R L+ + R E +L
Sbjct: 1240 EKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKL 1299
Query: 163 KRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALAR----QRARDLS 218
+R AEL ++ L E K + + S L + A+ R R +
Sbjct: 1300 QRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAME 1359
Query: 219 ETASALLAK-DKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQR 277
A+ L + +++ AA +R RELQ + +W R +E + L
Sbjct: 1360 AEAAGLREQLEEEAAARERAGRELQTAQAQLS----EW-------RRRQEEEAGALEAGE 1408
Query: 278 QIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRV 337
+ R RE L L + G Q++ D+ + L ++
Sbjct: 1409 EARRRAAREAEALTQR------LAEKTETVDRLERGRRRLQQELDDATMDL------EQQ 1456
Query: 338 QQLESELSKKRKKCESL-EQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEK 396
+QL S L KK++K + L +E R EE E + + AR + L +
Sbjct: 1457 RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAR 1516
Query: 397 EQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMR-------------E 443
E++E +N LR +L + +D + L+ EQ +R E
Sbjct: 1517 EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAE 1576
Query: 444 VAQRR-----QQLEVEHEQARLSLREKQEEVRR---LQQAQAEAQREHE--------GAV 487
A+ R Q L+ +HE+ E EE RR Q AE +R+ E A
Sbjct: 1577 DAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAAR 1636
Query: 488 QLLESTLDSMQARV-------RELEEQCRSQTEQFSLLAQELQAFR 526
+ LE L+ ++A++ E +Q R Q L +E++ R
Sbjct: 1637 KKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR 1682
Score = 35.8 bits (81), Expect = 0.40
Identities = 34/116 (29%), Positives = 57/116 (49%), Gaps = 15/116 (12%)
Query: 422 RKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ- 480
R+ + LQ++ + L++V +E+ Q++ EV Q R++ E +E R +Q +AEA+
Sbjct: 866 RQDEVLQARAQELQKV----QEL-QQQSAREVGELQGRVAQLE-EERARLAEQLRAEAEL 919
Query: 481 ----REHEGAV----QLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLH 528
E G + Q LE + ++ARV E EE R + L Q +Q H
Sbjct: 920 CAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAH 975
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 69.3 bits (168), Expect = 3e-11
Identities = 105/449 (23%), Positives = 176/449 (39%), Gaps = 71/449 (15%)
Query: 110 LKAKLNMSFGDRPNLELLRALGELRQR-----CAILKEENQMLRK-------------SS 151
L+A L G R L+L + E + + +L+++N L K S
Sbjct: 1013 LEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQ 1072
Query: 152 FPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKAL-A 210
E EEKV+ L + + +E+R RK ++ + G S EL + +
Sbjct: 1073 AAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQ 1132
Query: 211 RQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQR 270
+QRA +L A L R+ ELQA L EG + + LRE+Q
Sbjct: 1133 QQRAEELR-------------AQLGRKEEELQAALARAEDEGGARAQLL---KSLREAQA 1176
Query: 271 EVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGE 330
+ Q + T G L+A G E D L +
Sbjct: 1177 ALAEAQEDLESERVARTKAEKQRRDLGEELEALRG-------------ELEDTLDSTNAQ 1223
Query: 331 PEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLS 390
E + +Q +EL K +LE+E R + +EL + QA E A +E+ R
Sbjct: 1224 QELRSKREQEVTELKK------TLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK 1277
Query: 391 GRATEKEQ--VEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLE----QVLKHMREV 444
G A EK + +E E +ELR +L + R ++ + L+ +L+ ++ + E
Sbjct: 1278 G-AWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEA 1336
Query: 445 AQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLE----------STL 494
A++ Q+ + E E +L E + + RL + + + + A +LL+ S +
Sbjct: 1337 AEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRV 1396
Query: 495 DSMQARVRELEEQCRSQTEQFSLLAQELQ 523
+M+A L EQ + +ELQ
Sbjct: 1397 RAMEAEAAGLREQLEEEAAARERAGRELQ 1425
Score = 65.5 bits (158), Expect = 5e-10
Identities = 121/472 (25%), Positives = 194/472 (41%), Gaps = 62/472 (13%)
Query: 100 RPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKV 159
R E E L+A+L + ++ +++ EL + C + ++ LR + E E+++
Sbjct: 1557 REELERQNRALRAELEALLSSKDDVG--KSVHELERACRVAEQAANDLR-AQVTELEDEL 1613
Query: 160 RRLKRKNAELAVIAKRL---------------EERARKL--QETNLRVVSAPLPRPGTSL 202
+ L V + L EER R+L Q + V + T
Sbjct: 1614 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLA 1673
Query: 203 ELCRKALARQRARDLSETASALLAKD---KQIAALQRECREL--QARLTLVGKEGPQWLH 257
RK L + ++ ASA K+ KQ+ +Q + +EL + T +E +
Sbjct: 1674 VAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSRE-EIFSQ 1732
Query: 258 VRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQAR---AGAPAPGAPGE 314
R+ ++ L+ + EVLRLQ ++A ++ A Q R A A G +
Sbjct: 1733 NRESEKRLKGLEAEVLRLQEELAASDRARR----------QAQQDRDEMADEVANGNLSK 1782
Query: 315 ATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKK-----CESLEQEA---RKKQRRCE 366
A E+ L LG+ E+E +Q SEL R + ESL E R + E
Sbjct: 1783 AAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAE 1842
Query: 367 ELELQL-RQAQNENARLVEENSRLSGRATEKEQV---EWENAELRGQLLGVTQERDSALR 422
QL RQ Q RL EE++ RA K + E + A+ QL T+ER + +
Sbjct: 1843 SGRQQLERQIQELRGRLGEEDA--GARARHKMTIAALESKLAQAEEQLEQETRERILSGK 1900
Query: 423 KSQGLQSKLESLEQVLKHMREVA-QRRQQLE---VEHEQARLSLREKQEEVRRLQQAQAE 478
+ + +L+ + ++ R VA Q R QLE + +Q + L E +EE R Q +
Sbjct: 1901 LVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRR 1960
Query: 479 AQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPG 530
QRE E + + +SM V L + R F+ Q FRL G
Sbjct: 1961 LQRELEDVTE----SAESMNREVTTLRNRLRRGPLTFTTRTVR-QVFRLEEG 2007
Score = 59.7 bits (143), Expect = 3e-08
Identities = 88/340 (25%), Positives = 143/340 (42%), Gaps = 61/340 (17%)
Query: 224 LLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIA-LR 282
L K K + + R+ LQAR + K L ++S REV LQ ++A L
Sbjct: 895 LFTKVKPLLQVTRQDEVLQARAQELQK----------VQELQQQSAREVGELQGRVAQLE 944
Query: 283 NQRETLPLPPSWPPGPALQARAGAPAPGAPGE------ATPQE---DADNLPVILGEPEK 333
+R L A Q RA A E A QE L +GE E+
Sbjct: 945 EERARL----------AEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEE 994
Query: 334 ------------EQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENAR 381
+Q +Q+LE+ L + + L+ E + + ++ E L +++N++
Sbjct: 995 CSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSK 1054
Query: 382 LVEENSRL-------SGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESL 434
L +E L S +A E+E+ +LR + + + LRK + + +LE L
Sbjct: 1055 LSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKL 1114
Query: 435 EQVLK-HMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLEST 493
++ L E+ ++ + + E+ R L K+EE LQ A A A+ E QLL+S
Sbjct: 1115 KRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEE---LQAALARAEDEGGARAQLLKS- 1170
Query: 494 LDSMQARVRELEEQCRSQ-------TEQFSLLAQELQAFR 526
L QA + E +E S+ +Q L +EL+A R
Sbjct: 1171 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALR 1210
Score = 59.7 bits (143), Expect = 3e-08
Identities = 97/403 (24%), Positives = 154/403 (38%), Gaps = 80/403 (19%)
Query: 128 RALGELRQRCAILKEENQMLRK------SSFPETEEKVRRLKRKNAELAVIAKRLEERAR 181
R +GEL+ R A L+EE L + E EE RL + EL ++ LE R
Sbjct: 931 REVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVG 990
Query: 182 KLQETNLRVVSAPLPRPGTSLELCRKALARQRAR---DLSETASALLAKDKQIAALQREC 238
+ +E C + + ++ R + E + L A++ LQ E
Sbjct: 991 EEEE-------------------CSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEK 1031
Query: 239 RELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGP 298
+A++ + D LL E Q L +R++
Sbjct: 1032 VTTEAKMKKF-----------EEDLLLLEDQNSKLSKERKL------------------- 1061
Query: 299 ALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEA 358
L+ R + A E + + L + + E + +E L K+ K QE
Sbjct: 1062 -LEDRLAEFSSQAAEEEEKVKSLNKLRL-----KYEATIADMEDRLRKEEKG----RQEL 1111
Query: 359 RKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAE----LRGQLLGVT 414
K +RR + +L++ E + EE GR E+ Q AE R QLL
Sbjct: 1112 EKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSL 1171
Query: 415 QERDSALRKSQ-GLQSKLESLEQVLKHMREVAQRRQQLEVEHE------QARLSLREKQE 467
+E +AL ++Q L+S+ + + K R++ + + L E E A+ LR K+E
Sbjct: 1172 REAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKRE 1231
Query: 468 -EVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCR 509
EV L++ E R HE AVQ L + E EQ R
Sbjct: 1232 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQAR 1274
Score = 53.9 bits (128), Expect = 1e-06
Identities = 103/466 (22%), Positives = 175/466 (37%), Gaps = 66/466 (14%)
Query: 104 EEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETE-EKVRRL 162
E+ L+A+++ + +L+ R GE R+R L+ + R E +L
Sbjct: 1281 EKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKL 1340
Query: 163 KRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALAR----QRARDLS 218
+R AEL ++ L E K + + S L + A+ R R +
Sbjct: 1341 QRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAME 1400
Query: 219 ETASALLAK-DKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQR 277
A+ L + +++ AA +R RELQ + +W R +E + L
Sbjct: 1401 AEAAGLREQLEEEAAARERAGRELQTAQAQLS----EW-------RRRQEEEAGALEAGE 1449
Query: 278 QIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRV 337
+ R RE L L + G Q++ D+ + L ++
Sbjct: 1450 EARRRAAREAEALTQR------LAEKTETVDRLERGRRRLQQELDDATMDL------EQQ 1497
Query: 338 QQLESELSKKRKKCESL-EQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEK 396
+QL S L KK++K + L +E R EE E + + AR + L +
Sbjct: 1498 RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAR 1557
Query: 397 EQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMR-------------E 443
E++E +N LR +L + +D + L+ EQ +R E
Sbjct: 1558 EELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAE 1617
Query: 444 VAQRR-----QQLEVEHEQARLSLREKQEEVRR---LQQAQAEAQREHE--------GAV 487
A+ R Q L+ +HE+ E EE RR Q AE +R+ E A
Sbjct: 1618 DAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAAR 1677
Query: 488 QLLESTLDSMQARV-------RELEEQCRSQTEQFSLLAQELQAFR 526
+ LE L+ ++A++ E +Q R Q L +E++ R
Sbjct: 1678 KKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR 1723
Score = 35.8 bits (81), Expect = 0.40
Identities = 34/116 (29%), Positives = 57/116 (49%), Gaps = 15/116 (12%)
Query: 422 RKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ- 480
R+ + LQ++ + L++V +E+ Q++ EV Q R++ E +E R +Q +AEA+
Sbjct: 907 RQDEVLQARAQELQKV----QEL-QQQSAREVGELQGRVAQLE-EERARLAEQLRAEAEL 960
Query: 481 ----REHEGAV----QLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLH 528
E G + Q LE + ++ARV E EE R + L Q +Q H
Sbjct: 961 CAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAH 1016
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 68.9 bits (167), Expect = 4e-11
Identities = 64/256 (25%), Positives = 124/256 (48%), Gaps = 29/256 (11%)
Query: 276 QRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQ 335
QR++ L+ Q E P P P LQ P P + PQ+D L + EK Q
Sbjct: 86 QRELQLQ-QLEQQPEPQQQPQHEQLQQ----PQPHLELQQQPQQDGQQQLSQL-QQEKHQ 139
Query: 336 RV--QQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRA 393
V Q+L+ EL ++ + L+ + ++Q+R ++ + QL+ Q + +++++ +L +
Sbjct: 140 SVHHQELKPELQLMHQQ-QQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQV 198
Query: 394 TEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEV 453
E++ + Q++ L++ Q LQ + + +Q + +E Q++QQL +
Sbjct: 199 QEQQ---------------LLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLL 243
Query: 454 EHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTE 513
+Q +L Q+++ + QQAQ + Q + QL + L Q ++++ ++Q Q +
Sbjct: 244 LQQQGQL-----QQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQ 298
Query: 514 QFSLLAQELQAFRLHP 529
Q L Q+LQ L P
Sbjct: 299 QEQLQQQQLQPPPLEP 314
Score = 62.0 bits (149), Expect = 5e-09
Identities = 50/197 (25%), Positives = 109/197 (55%), Gaps = 12/197 (6%)
Query: 332 EKEQRVQQLESEL-SKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLS 390
+++QR+QQ + +L +++ ++ + L+Q+ + +Q+ E+ LQ +Q Q + +L+++ +L
Sbjct: 165 QEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQ 224
Query: 391 GRATEKEQVEWENAELRGQLLGVTQE---RDSALRKSQG-LQSKLESLEQVLKHMREVAQ 446
+ +++Q E + + QLL + Q+ + L++ Q LQ +L +Q + + Q
Sbjct: 225 QQQFQQQQ---EQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQ 281
Query: 447 RRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEE 506
+++QL+ + +Q L +++Q + ++LQ E + E E ++L+ L S Q ELE+
Sbjct: 282 QQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQ----ELEQ 337
Query: 507 QCRSQTEQFSLLAQELQ 523
Q + Q L Q+ Q
Sbjct: 338 QRQELERQQELERQQEQ 354
Score = 57.0 bits (136), Expect = 2e-07
Identities = 55/230 (23%), Positives = 113/230 (49%), Gaps = 41/230 (17%)
Query: 314 EATPQEDADNLPVILGEPEKEQRVQ--QLESELSKKRKKCESLEQEARKKQRRCEELELQ 371
E + A V+ + + +Q+VQ QL + ++ ++ + L+Q+ + +Q++ ++ + Q
Sbjct: 175 EQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQ 234
Query: 372 LRQAQNENARLVEENSRLSGRATEKEQ-------VEWENAELRGQLLGVTQERDSALRKS 424
L+Q Q L+++ +L + +++Q +E + A+L+ QLL QE+ ++
Sbjct: 235 LQQQQQ--LLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQ 292
Query: 425 QGLQSKLESL-----------------------------EQVLKHMREVAQRRQQLEVEH 455
Q LQ + E L EQ L+ R+ +R+Q+LE +
Sbjct: 293 QLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQ 352
Query: 456 EQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELE 505
EQ +L L+ QEE+++L+Q + Q++ E LE T + A+ +E++
Sbjct: 353 EQRQLQLK-LQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQ 401
Score = 53.9 bits (128), Expect = 1e-06
Identities = 61/261 (23%), Positives = 122/261 (46%), Gaps = 29/261 (11%)
Query: 293 SWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCE 352
S P PA+ A GA E P + L + +PE +Q+ Q +L + + E
Sbjct: 62 SSPQRPAVSAPVGASEIAE--ETRPGQRELQLQQLEQQPEPQQQPQH--EQLQQPQPHLE 117
Query: 353 SLEQEARKKQRRCEELELQLRQAQNENA-----RLVEENSRLSGRATEKEQVEWENAELR 407
+Q + Q++ +L+ + Q+ + +L+ + +L + +++Q + E
Sbjct: 118 LQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQE-- 175
Query: 408 GQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARL------- 460
QL + L++ + LQ +++ +Q+L+ +E Q+ QQL + EQ +
Sbjct: 176 -QLQTQQAQEQQVLQQQEQLQQQVQE-QQLLQQQQEQLQQ-QQLLQQQEQLQQQQFQQQQ 232
Query: 461 -SLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRE---LEEQCRSQTEQFS 516
L+++Q+ + QQ Q + Q + QL + L+ QA++++ L++Q + Q +Q
Sbjct: 233 EQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQ 292
Query: 517 LLAQ----ELQAFRLHPGPLD 533
L Q +LQ +L P PL+
Sbjct: 293 QLLQQQQEQLQQQQLQPPPLE 313
>gi|154354987 hook homolog 2 isoform 2 [Homo sapiens]
Length = 717
Score = 68.9 bits (167), Expect = 4e-11
Identities = 107/447 (23%), Positives = 174/447 (38%), Gaps = 56/447 (12%)
Query: 128 RALGELRQRCAILKEENQMLRKSS--FPETEEKVRRLKRKNAELAVIAKRLEERARKLQE 185
+AL L Q LK+E LR+SS + E + +R+ EL + L + R+L+E
Sbjct: 281 QALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGEL----RELRRQVRQLEE 336
Query: 186 TNL------RVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECR 239
N R + L R G+ R L QR R + E + + ECR
Sbjct: 337 RNAGHAERTRQLEDELRRAGS----LRAQLEAQR-RQVQELQGQRQEEAMKAEKWLFECR 391
Query: 240 ELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPA 299
L+ + V KE + L RD LRE+ E+ Q Q Q + P S P
Sbjct: 392 NLEEKYESVTKEKERLLAERDS---LREANEELRCAQLQPRGLTQADPSLDPTSTP---- 444
Query: 300 LQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEAR 359
+ A P E + +N + E +R ++L+ L + LE + R
Sbjct: 445 VDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHR 504
Query: 360 KKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERD- 418
Q++ EL Q+ Q L E+ + K ++E +L L + ++R+
Sbjct: 505 LNQQQLSELRAQVEDLQKA---LQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREY 561
Query: 419 ----------SALRKSQGLQSKLESLEQVLKHMREVAQR--------RQQLEVEHEQA-- 458
S R+ + LQ L+ + L+ M E +R Q +E + A
Sbjct: 562 IEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAG 621
Query: 459 --------RLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRS 510
R LRE+ +R L+ +++ + E +LL S +M +++ + R+
Sbjct: 622 APPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERA 681
Query: 511 QTEQFSLLAQELQAFRLHPGPLDLLTS 537
S LAQ+ A GPL L S
Sbjct: 682 PAHAQSFLAQQRLATNSRRGPLGRLAS 708
Score = 61.2 bits (147), Expect = 9e-09
Identities = 97/438 (22%), Positives = 170/438 (38%), Gaps = 69/438 (15%)
Query: 132 ELRQRCAILKEENQML--RKSSFPETEEKVR-RLKRKNAE--LAVIAKRL---EERARKL 183
EL+QRC L+ + +L K S + +R R+ R E + AK+L + + +L
Sbjct: 189 ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQL 248
Query: 184 QETNLRVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQA 243
QE N R+ S G E R A + +L AL + ++ AL+ E EL+
Sbjct: 249 QEENFRLES------GREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ 302
Query: 244 RLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQAR 303
G+ R LRE +R+V +L+ + A G A + R
Sbjct: 303 SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNA----------------GHAERTR 346
Query: 304 AGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQR 363
G Q +A V + ++++ + E L + R E E ++K+R
Sbjct: 347 QLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKER 406
Query: 364 RCEELEL------QLRQAQNENARLVEENSRLSGRATEKEQVEWE--NAELRGQLLGVTQ 415
E + +LR AQ + L + + L +T + + E AELR LL +
Sbjct: 407 LLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQL 466
Query: 416 ERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEH-------------------- 455
E R+ + + E L+ +H+ + + R LE +H
Sbjct: 467 ENKRLCRQEAADRERQEELQ---RHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKA 523
Query: 456 --------EQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQ 507
E + L R+ +E +++L +A E QR+ E +L T S R+ EL+
Sbjct: 524 LQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHN 583
Query: 508 CRSQTEQFSLLAQELQAF 525
+ + + + + +
Sbjct: 584 LQKKDADLRAMEERYRRY 601
Score = 45.1 bits (105), Expect = 7e-04
Identities = 57/242 (23%), Positives = 101/242 (41%), Gaps = 53/242 (21%)
Query: 356 QEARKKQRRCEELELQLRQAQNENARLVEENSRLSGR--------------------ATE 395
+E + Q+RC +LE QL E L +EN+ L R ++
Sbjct: 185 EEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQ 244
Query: 396 KEQVEWENAELRG-----QLLGVTQERDSA--LRKSQGLQS---KLESLEQVLKHMREVA 445
EQ++ EN L +L ER+ A ++Q L S + ++L+ + +R+ +
Sbjct: 245 LEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSS 304
Query: 446 QRRQQLEVEHEQARL---SLREKQEEVRRLQQ---AQAEAQREHEGAVQ---LLESTLDS 496
+R QLE R LRE + +VR+L++ AE R+ E ++ L + L++
Sbjct: 305 ERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEA 364
Query: 497 MQARVRELEEQ--------------CRSQTEQFSLLAQELQAFRLHPGPLDLLTSALDCG 542
+ +V+EL+ Q CR+ E++ + +E + L L C
Sbjct: 365 QRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCA 424
Query: 543 SL 544
L
Sbjct: 425 QL 426
Score = 38.9 bits (89), Expect = 0.047
Identities = 44/175 (25%), Positives = 77/175 (44%), Gaps = 41/175 (23%)
Query: 389 LSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKL-------------ESLE 435
LS A E ++++ +L QL+ +++E+ S +++ GL+ ++ + L
Sbjct: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
Query: 436 QVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRL-----------QQAQA------E 478
+ + ++ + +LE E RL E + EV L Q+AQA E
Sbjct: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE 299
Query: 479 AQREHEGAVQLLESTLDSMQAR----------VRELEEQCRSQTEQFSLLAQELQ 523
++ E A Q LE+TL S + R VR+LEE+ E+ L EL+
Sbjct: 300 LRQSSERAGQ-LEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELR 353
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 68.6 bits (166), Expect = 6e-11
Identities = 103/470 (21%), Positives = 200/470 (42%), Gaps = 63/470 (13%)
Query: 78 EGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRC 137
E +A + QAS++G + + LK K +R + L+ GEL+
Sbjct: 1358 EHLQAAVVEARAQASAAG--ILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQ 1415
Query: 138 AILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPR 197
+EN L + E EE+V L+ + EL E+ R++Q+ L ++S L +
Sbjct: 1416 GKALQENLALLTQTLAEREEEVETLRGQIQEL--------EKQREMQKAALELLSLDLKK 1467
Query: 198 PGTSLELCRKALAR-QRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWL 256
++L ++ + ++ R + E + + +Q +QRE
Sbjct: 1468 RNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQRE------------------- 1508
Query: 257 HVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEAT 316
+R+ ++ RE+QR VL + Q+ +++ + ++++ G T
Sbjct: 1509 QIRELEKD-RETQRNVL--EHQLLELEKKDQM-----------IESQRGQVQDLKKQLVT 1554
Query: 317 PQEDADNLPVILGEPEKEQR-VQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQA 375
+ A L + E +Q+ +++LE + +R L + ++ + + Q+
Sbjct: 1555 LECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDL 1614
Query: 376 QNENARLVEE-NSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESL 434
++ + L E R +++EQ+E EL+ Q +TQ+ + R+ Q L + E +
Sbjct: 1615 ESHSTVLARELQERDQEVKSQREQIE----ELQRQKEHLTQDLE---RRDQELMLQKERI 1667
Query: 435 EQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTL 494
QVL+ R ++ + LE + EQ +LSLRE+ E+ +Q E E +G + +L
Sbjct: 1668 -QVLEDQR--TRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSL 1724
Query: 495 DSMQARVRELEEQCRSQTEQF-------SLLAQELQAFRLHPGPLDLLTS 537
+ M+ +R+ E++ Q E L Q+LQ G LL S
Sbjct: 1725 EHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLS 1774
Score = 67.4 bits (163), Expect = 1e-10
Identities = 99/417 (23%), Positives = 175/417 (41%), Gaps = 55/417 (13%)
Query: 132 ELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLE------ERARKLQE 185
EL++R +K + + + + + E + L+R++ EL + +R++ R K+ E
Sbjct: 1624 ELQERDQEVKSQREQIEELQ-RQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILE 1682
Query: 186 TNLRVVSAPLPRPGTSLELCRKALARQRARD-----------LSETASALLAKDKQIAAL 234
+L + L G L R+ L ++RA + L L K+K++
Sbjct: 1683 EDLEQIKLSLRERGRELTTQRQ-LMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQ 1741
Query: 235 QRECRELQARLTLVGKEGPQWLH--VRDFDRLLRESQREVLRLQRQIALRNQRETLPLPP 292
Q ELQ + ++ Q LH V + LL + ++E++ LQ+Q L+ RE L
Sbjct: 1742 QEHIHELQELKDQLEQQ-LQGLHRKVGETSLLLSQREQEIVVLQQQ--LQEAREQGELKE 1798
Query: 293 SWPPGPALQARAGAPAPGAPGEATPQEDA----------DNLPVILGEPEK-EQRVQQLE 341
+A+ EA QE + + G E+ +++
Sbjct: 1799 QSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERH 1858
Query: 342 SELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEW 401
EL +++ LE+E + RR + LE L + E+ +E + L+ + EQ +
Sbjct: 1859 GELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESRE--QEKALLALQQQCAEQAQE 1916
Query: 402 ENAELRG------QLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQ-LEVE 454
E R Q V +ERD L L + Q +H E A+ R + L+
Sbjct: 1917 HEVETRALQDSWLQAQAVLKERDQELEA-------LRAESQSSRHQEEAARARAEALQEA 1969
Query: 455 HEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQ 511
+A +L+ K++ + QAE R E + L+++LD+ QA R+LEE R Q
Sbjct: 1970 LGKAHAALQGKEQHLLE----QAELSRSLEASTATLQASLDACQAHSRQLEEALRIQ 2022
Score = 65.5 bits (158), Expect = 5e-10
Identities = 165/696 (23%), Positives = 273/696 (39%), Gaps = 111/696 (15%)
Query: 43 ADTPPAALQ--LQELRSEESSKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQR 100
A+ A LQ L++++ E+ K SR E A L L Q+A R
Sbjct: 671 AEEAGAELQADLRDIQEEKEEIQKKLSESRH----QQEAATTQLEQLHQEAKRQEEVLAR 726
Query: 101 PEDEEV-----EAFLKAKLNMSFGDRPNL-ELLRALGELRQRCAILKEENQMLRKSSFPE 154
E+ +A L+ +L DR +L E L+ L ++ L +SS E
Sbjct: 727 AVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKE-----------LLESSLFE 775
Query: 155 TEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQRA 214
+++ ++ +L V + + + A+++ + +R + L + E R A ARQ A
Sbjct: 776 AQQQNSVIEVTKGQLEVQIQTVTQ-AKEVIQGEVRCLKLELDTERSQAEQERDAAARQLA 834
Query: 215 RDLSETASAL----LAKDKQI----------------------AALQRECRELQARLTLV 248
+ E +AL A +K++ +L+RE EL+ RL
Sbjct: 835 QAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRL--- 891
Query: 249 GKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQR----ETLPLPPSWPPGPALQARA 304
KE + R +Q E Q Q+ +R ETL L A Q
Sbjct: 892 -KEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETL-LQTQKELADASQQLE 949
Query: 305 GAPAPGAPGEATPQEDADNLPVILGEPEKE--QRVQQLESELSKKRKKCESLEQEARKKQ 362
+ QE L L E ++E + +Q +L+ +++ SL Q+ Q
Sbjct: 950 RLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQ 1009
Query: 363 RRCEELELQLRQAQNENARLVEENSRLSGRATEK-----EQVEWENAEL------RGQLL 411
++ E+L+ QL AQ+++ RLVE+ + R T++ +++E E A L + Q L
Sbjct: 1010 KQVEDLKSQL-VAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRL 1068
Query: 412 GVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRR 471
V QE DS Q +L +L Q M+E +++L + E R ++EK+ +
Sbjct: 1069 LVLQEADSIR------QQELSALRQ---DMQEAQGEQKELSAQMELLRQEVKEKEADFLA 1119
Query: 472 LQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGP 531
+ E Q L ++L + +A+ +L+ + RS Q LA E Q
Sbjct: 1120 QEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQ 1179
Query: 532 LDL--LTSALDCGSLGDCPPPPCCCSIPQPCRG--SGPKDLDLPPGSPGRCTPKSSEPAP 587
L L SAL +LG C S P+ G S P L P G A
Sbjct: 1180 AQLASLYSALQ-QALGS-----VCESRPELSGGGDSAPSVWGLEPDQNG---------AR 1224
Query: 588 ATLTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAAPE 647
+ P TA AE+++++ H +H +V++LE L E
Sbjct: 1225 SLFKRGPLLTALSAEAVASALH--KLHQDLWKTQQTRDVLRDQVQKLEE---RLTDTEAE 1279
Query: 648 GSRGGARIQVFLARYSYN-----PFEGPNENPEAEL 678
S+ +Q + S N +EG + E+EL
Sbjct: 1280 KSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESEL 1315
Score = 60.5 bits (145), Expect = 2e-08
Identities = 114/463 (24%), Positives = 181/463 (39%), Gaps = 54/463 (11%)
Query: 103 DEEVEAFLKAKLNMSFGDRPNLELLRAL-GELRQRCAILKEENQMLRKSSFPETEEKVRR 161
D+E+EA + + + E AL G L Q LKE R + +E+ RR
Sbjct: 1816 DQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE-----RHGELQDHKEQARR 1870
Query: 162 LKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQRARDLSETA 221
L+ ELAV +R++ L V L E AL +Q A E
Sbjct: 1871 LEE---ELAVEGRRVQA---------LEEVLGDLRAESREQEKALLALQQQCAEQAQEHE 1918
Query: 222 SALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIAL 281
A Q +E L + E H + R E+ +E L
Sbjct: 1919 VETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQ 1978
Query: 282 RNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKE-----QR 336
++ L A A A + E+A L + GE + + +
Sbjct: 1979 GKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEA--LRIQEGEIQDQDLRYQED 2036
Query: 337 VQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEK 396
VQQL+ L+++ ++E R +Q R + LE L Q EN +++E L G+ E+
Sbjct: 2037 VQQLQQALAQR-------DEELRHQQEREQLLEKSLAQRVQEN--MIQEKQNL-GQEREE 2086
Query: 397 EQVEWENAELRGQLLGVTQERDSALRKSQGLQ-SKLESL----------EQVLKHMREVA 445
E++ + +R L + Q+ L + Q + LE+L EQ LK +
Sbjct: 2087 EEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLK--LDSL 2144
Query: 446 QRRQQLEVEHEQARLSLREKQE-EVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVREL 504
+ R Q E+E QA L E +E E R Q A + + + +V L+ +QA V E
Sbjct: 2145 EPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLER 2204
Query: 505 EEQCRSQTEQFSLLAQELQAFRLH-PGPLDLLTSALDCGSLGD 546
+ + + ++ L + L+ RLH PG TS + GS G+
Sbjct: 2205 DSEQQRLQDELELTRRALEKERLHSPG----ATSTAELGSRGE 2243
Score = 60.1 bits (144), Expect = 2e-08
Identities = 69/327 (21%), Positives = 143/327 (43%), Gaps = 22/327 (6%)
Query: 210 ARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHV----RDFDRLL 265
A +R+++L + S D + A LQ EL A LT K+ + + R+ +L
Sbjct: 260 AHERSQELIQLKSQ---GDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL 316
Query: 266 RESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLP 325
+ E++ + ++ Q E L L + G G E ++
Sbjct: 317 ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIF 376
Query: 326 VILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEE 385
+ ++ + + S L+++R+ + L Q+ Q L+ Q Q + E L +
Sbjct: 377 SQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQR 436
Query: 386 NSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVA 445
+L+G E++ + + +L+G++ +++ER+ + + L+ +LE LEQ +R V
Sbjct: 437 LQKLTG---ERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVN 493
Query: 446 QRRQ--------QLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSM 497
Q Q E + E+ L++RE++ RLQ+ + + ++ L + +++
Sbjct: 494 VELQLQGDSAQGQKEEQQEELHLAVRERE----RLQEMLMGLEAKQSESLSELITLREAL 549
Query: 498 QARVRELEEQCRSQTEQFSLLAQELQA 524
++ E E + QTE + LA+ Q+
Sbjct: 550 ESSHLEGELLRQEQTEVTAALARAEQS 576
Score = 58.9 bits (141), Expect = 4e-08
Identities = 98/433 (22%), Positives = 171/433 (39%), Gaps = 84/433 (19%)
Query: 143 ENQML---RKSSFPETEE-KVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRP 198
E+Q+L +K E++ +V+ LK++ L +A LEE K++ + R
Sbjct: 1525 EHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRE 1584
Query: 199 GTSLELCRKALARQRARDLSETASALLAKDKQIAALQRE----CRELQARLTLVGKEGPQ 254
+ L L DL E + L A+ QI L+ RELQ R V + Q
Sbjct: 1585 TQRVALTHLTL------DLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQ 1638
Query: 255 W-------------LHVRDFDRLLRESQREVLRLQR--------------QIALRNQRET 287
L RD + +L++ + +VL QR +++LR +
Sbjct: 1639 IEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRE 1698
Query: 288 LPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKK 347
L +Q RA G + +++ +IL + EKE QQ + +
Sbjct: 1699 LTTQRQ-----LMQERA---EEGKGPSKAQRGSLEHMKLILRDKEKEVECQQ--EHIHEL 1748
Query: 348 RKKCESLEQEARKKQRRCEELELQLRQAQNE----------------------NARLVEE 385
++ + LEQ+ + R+ E L L Q + E ++L E
Sbjct: 1749 QELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEA 1808
Query: 386 NSRLSGRATEKEQVEWENAELRGQ----------LLGVTQERDSALRKSQG-LQSKLESL 434
L+ R E E ++ E + +GQ L G ++ L++ G LQ E
Sbjct: 1809 QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQA 1868
Query: 435 EQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTL 494
++ + + +R Q LE R RE+++ + LQQ AE +EHE + L+ +
Sbjct: 1869 RRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSW 1928
Query: 495 DSMQARVRELEEQ 507
QA ++E +++
Sbjct: 1929 LQAQAVLKERDQE 1941
Score = 57.8 bits (138), Expect = 1e-07
Identities = 106/428 (24%), Positives = 181/428 (42%), Gaps = 74/428 (17%)
Query: 130 LGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLR 189
L E +R L E+N L ++ + EE L+ A+L I + EE +KL E+ +
Sbjct: 647 LAEAEKRREALWEKNTHL-EAQLQKAEEAGAELQ---ADLRDIQEEKEEIQKKLSESRHQ 702
Query: 190 VVSAPLPRPGTSLELCRKALARQR---ARDLSETASALLAK---DKQIAALQRECRELQA 243
+A T LE + RQ AR + E + + K + ++ A++R+ ++L
Sbjct: 703 QEAAT-----TQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAE 757
Query: 244 RLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRET----------LPLPPS 293
+L + + L F+ + S EV + Q ++ ++ + L L
Sbjct: 758 QLQGLSS-AKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELD 816
Query: 294 WPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCES 353
A Q R A A E QE G+ EQ+ E E+++ R+K E
Sbjct: 817 TERSQAEQERDAAARQLAQAE---QE---------GKTALEQQKAAHEKEVNQLREKWE- 863
Query: 354 LEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGV 413
+++ +EL L + E L RL + TE E ++ + E R Q
Sbjct: 864 -----KERSWHQQELAKALESLEREKMEL---EMRLKEQQTEMEAIQAQREEERTQA--- 912
Query: 414 TQERDSALRKSQGLQSKLES---LEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVR 470
+SAL + Q L+++ E LE +L+ +E+A QQLE + ++ ++QE
Sbjct: 913 ----ESALCQMQ-LETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTG 967
Query: 471 RLQQAQAEAQRE---------------HEGAVQLLESTLDSMQARVRELEEQCRSQTEQF 515
LQ EAQRE E + LL+ +D +Q +V +L+ Q +Q +
Sbjct: 968 ILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMD-LQKQVEDLKSQLVAQDDSQ 1026
Query: 516 SLLAQELQ 523
L+ QE+Q
Sbjct: 1027 RLVEQEVQ 1034
Score = 56.2 bits (134), Expect = 3e-07
Identities = 112/532 (21%), Positives = 208/532 (39%), Gaps = 130/532 (24%)
Query: 99 QRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFP---ET 155
Q+ +++E L+ +L + EL A + R A L+EE+ L + +
Sbjct: 958 QKLKEQETTGILQTQLQEA-----QRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQV 1012
Query: 156 EEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELC-----RKALA 210
E+ +L ++ ++ + ++E+ R+ QE N + L R SL L ++ L
Sbjct: 1013 EDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNR--IQKELEREKASLTLSLMEKEQRLLV 1070
Query: 211 RQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQ- 269
Q A + + + L +D Q A Q E +EL A++ L+ +E + ++ D L +E+Q
Sbjct: 1071 LQEADSIRQQELSALRQDMQEA--QGEQKELSAQMELLRQEVKE----KEADFLAQEAQL 1124
Query: 270 --------------------REVLRLQRQIALRNQRETLP-LPPSWPPGPALQARAGAP- 307
+E Q Q+ LR+ L L PG QA+A
Sbjct: 1125 LEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLAS 1184
Query: 308 -------APGAPGEATPQEDA--DNLPVILG-EPEK------------------------ 333
A G+ E+ P+ D+ P + G EP++
Sbjct: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244
Query: 334 -------------------------EQRVQQLESELSKKRKKCESLEQEARKKQRRCEEL 368
E+R+ E+E S+ + + L+++ + Q +
Sbjct: 1245 LHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKW 1304
Query: 369 ELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQ 428
E + ++E L E + L R + E + E +G ER+ + L
Sbjct: 1305 EGKQNSLESELMELHETMASLQSRL---RRAELQRMEAQG-------ERELLQAAKENLT 1354
Query: 429 SKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVR-------------RLQQA 475
+++E L+ + R A LE + AR +L+ K EEV L+ A
Sbjct: 1355 AQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVA 1414
Query: 476 QAEAQREHEGAV-QLL---ESTLDSMQARVRELEEQCRSQTEQFSLLAQELQ 523
Q +A +E+ + Q L E +++++ +++ELE+Q Q LL+ +L+
Sbjct: 1415 QGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK 1466
Score = 53.9 bits (128), Expect = 1e-06
Identities = 100/421 (23%), Positives = 164/421 (38%), Gaps = 94/421 (22%)
Query: 126 LLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQE 185
L +A ELRQ+ +L E++ RL+R N EL + + + + QE
Sbjct: 468 LQKAREELRQQLEVL---------------EQEAWRLRRVNVELQLQGDSAQGQKEEQQE 512
Query: 186 TNLRVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARL 245
L L R+R R L E L AK + L +
Sbjct: 513 ---------------ELHLA----VRERER-LQEMLMGLEAKQSE---------SLSELI 543
Query: 246 TLVGKEGPQWLHVRDFDRLLRESQREV----LRLQRQIA-LRNQRETLPLPPSWPPGPAL 300
TL +E + H+ LLR+ Q EV R ++ IA L + TL
Sbjct: 544 TL--REALESSHLE--GELLRQEQTEVTAALARAEQSIAELSSSENTLKT-------EVA 592
Query: 301 QARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARK 360
RA A A EA + L + Q++ QLE E + E+ EQ
Sbjct: 593 DLRAAAVKLSALNEA----------LALDKVGLNQQLLQLEEENQSVCSRMEAAEQAR-- 640
Query: 361 KQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSA 420
L++ L +A+ L E+N+ L + + E+ AEL+ L + +E++
Sbjct: 641 -----NALQVDLAEAEKRREALWEKNTHLEAQLQKAEEA---GAELQADLRDIQEEKEEI 692
Query: 421 LRK-------SQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQ 473
+K + ++LE L Q K EV R Q + + + +L + + V R +
Sbjct: 693 QKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDR 752
Query: 474 QAQAEAQREHEGAVQLLESTLDSMQAR-------VRELEEQCRSQTEQFSLLAQELQAFR 526
Q AE + A +LLES+L Q + +LE Q ++ T+ ++ E++ +
Sbjct: 753 QDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLK 812
Query: 527 L 527
L
Sbjct: 813 L 813
Score = 52.8 bits (125), Expect = 3e-06
Identities = 96/420 (22%), Positives = 173/420 (41%), Gaps = 40/420 (9%)
Query: 97 ACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETE 156
A + D+E+EA L+A+ S R E RA E Q ++ E
Sbjct: 1933 AVLKERDQELEA-LRAESQSS---RHQEEAARARAEALQEALGKAHAALQGKEQHLLEQA 1988
Query: 157 EKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLP----RPGTSLELCRKALARQ 212
E R L+ A L + +R+L+E LR+ + R ++ ++ALA Q
Sbjct: 1989 ELSRSLEASTATLQASLDACQAHSRQLEEA-LRIQEGEIQDQDLRYQEDVQQLQQALA-Q 2046
Query: 213 RARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQ----WLH--VRDFDRLLR 266
R +L +K +A +E +Q + L G+E + LH VR+ L
Sbjct: 2047 RDEELRHQQEREQLLEKSLAQRVQE-NMIQEKQNL-GQEREEEEIRGLHQSVRELQLTLA 2104
Query: 267 ESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPV 326
+ ++E+L L R+ RN E LP P + + P Q + + L
Sbjct: 2105 QKEQEILEL-RETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRL------QRELERLQA 2157
Query: 327 ILGEPEKEQ-----RVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNE--- 378
L + E + + Q L L++ + SL++ A Q E + + ++ Q+E
Sbjct: 2158 ALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELEL 2217
Query: 379 NARLVEENSRLSGRATEKEQV--EWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQ 436
R +E+ S AT ++ E G++ GV E + Q + +LE L+Q
Sbjct: 2218 TRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQ 2277
Query: 437 VLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDS 496
+ + R +L+ + Q R +L + + E R+L++ A + G++++ ++T S
Sbjct: 2278 AVARLE---IDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQ--AGSLEISKATASS 2332
Score = 48.1 bits (113), Expect = 8e-05
Identities = 55/210 (26%), Positives = 91/210 (43%), Gaps = 24/210 (11%)
Query: 334 EQRVQQLESELSKKRKKCESLEQEARKK-------QRRCEELELQLRQAQNENARLVEEN 386
++++ Q + E SK K SLE E + Q R ELQ +AQ E L
Sbjct: 1291 QRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAK 1350
Query: 387 SRLSGRATEKEQVEWENAELRGQLLGVTQE-----RDSALRKSQGLQSKLESLEQVLKHM 441
L+ + E Q A + G+ +E R + K++ ++S+ E + + +
Sbjct: 1351 ENLTAQ-VEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQG 1409
Query: 442 REVAQRRQQLEVEHEQARLSLREKQEEVRRL--QQAQAEAQRE-HEGAVQLLESTL---- 494
+ + L+ +L E++EEV L Q + E QRE + A++LL L
Sbjct: 1410 ELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRN 1469
Query: 495 ---DSMQARVRELEEQCRSQTEQFSLLAQE 521
D Q +++EL E+CRS E + QE
Sbjct: 1470 QEVDLQQEQIQEL-EKCRSVLEHLPMAVQE 1498
Score = 33.1 bits (74), Expect = 2.6
Identities = 27/96 (28%), Positives = 46/96 (47%), Gaps = 9/96 (9%)
Query: 161 RLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQRARDLSET 220
RL+R N +L +++E RKL+ +R A SLE+ + + +D
Sbjct: 2288 RLQRHNVQLRSTLEQVERERRKLKREAMRAAQAG------SLEISKATASSPTQQDGRGQ 2341
Query: 221 ASALLAKDKQIAALQRECRELQARLTLVGKEGPQWL 256
++ K +A LQ+E LQA+LTL K+ ++
Sbjct: 2342 KNS---DAKCVAELQKEVVLLQAQLTLERKQKQDYI 2374
Score = 31.6 bits (70), Expect = 7.5
Identities = 49/212 (23%), Positives = 84/212 (39%), Gaps = 47/212 (22%)
Query: 330 EPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRL 389
E +E + +L L +++++CESL + +L L + +A N L E+
Sbjct: 89 ENVEEPNLDELLVRLEEEQQRCESLAEVN-------TQLRLHMEKADVVNKALRED---- 137
Query: 390 SGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKH--------M 441
EK V+W A RD +RK Q + E + LK
Sbjct: 138 ----VEKLTVDWSRA------------RDELMRKESQWQMEQEFFKGYLKGEHGRLLSLW 181
Query: 442 REVAQ-RRQQLEVEHEQARLSLREKQEEVRR--------LQQAQAEAQREHEGAVQL--- 489
REV RR LE++ R + K E VR L+ RE G+ ++
Sbjct: 182 REVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGR 241
Query: 490 LESTLDSMQARVRELEEQCRSQTEQFSLLAQE 521
+ L + A+ +ELE++ ++++ L +
Sbjct: 242 EPAQLLLLLAKTQELEKEAHERSQELIQLKSQ 273
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 68.6 bits (166), Expect = 6e-11
Identities = 104/464 (22%), Positives = 180/464 (38%), Gaps = 83/464 (17%)
Query: 89 QQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLR 148
Q+A + E++ V A KAKL + +E L E ++ + E +
Sbjct: 1049 QEAHQQALGDLQAEEDRVSALTKAKLRLE----QQVEDLECSLEQEKKLRMDTERAKRKL 1104
Query: 149 KSSFPETEEKV-----------RRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPR 197
+ T+E V +LK+K++EL+ ++ R+E+ +++ A + +
Sbjct: 1105 EGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDE---------QLLGAQMQK 1155
Query: 198 PGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVG------KE 251
L+ A A + +L +A +KQ A RE EL RL G +E
Sbjct: 1156 KIKELQ----ARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQRE 1211
Query: 252 GPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGA 311
G + + RL RE + LR + +A +++ A
Sbjct: 1212 GCRKREA-ELGRLRRELEEAALRHEATVAALRRKQ------------------------A 1246
Query: 312 PGEATPQEDADNLPVILGEPEKEQ------------RVQQLESELSKKRKKCESLEQEAR 359
G A E D+L + + EKE+ V+ L + K C + E +
Sbjct: 1247 EGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLS 1306
Query: 360 KKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDS 419
+ + + EEL+ QL A + RL E+ LS EKE + + + + +E
Sbjct: 1307 EAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRR 1366
Query: 420 ALRKSQGLQSKLESLEQVLKH----MREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQA 475
L + +S L Q L+H +RE Q ++ E + E RL + E + +
Sbjct: 1367 QLEEESKAKSALAHAVQALRHDCDLLRE--QHEEEAEAQAELQRLLSKANAEVAQWRSKY 1424
Query: 476 QAEA-QREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLL 518
+A+A QR E LE + R++E EE + + S L
Sbjct: 1425 EADAIQRTEE-----LEEAKKKLALRLQEAEEGVEAANAKCSSL 1463
Score = 62.4 bits (150), Expect = 4e-09
Identities = 115/477 (24%), Positives = 207/477 (43%), Gaps = 61/477 (12%)
Query: 80 AEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFG---DRPNLELLRALGELRQR 136
AE + + + SS A R + E + L+ + S D+ L RAL E R
Sbjct: 1449 AEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERR-- 1506
Query: 137 CAILKEENQMLRKSSFPETEEK-----VRRLKRKNAELAVIAKRLEERARKLQETNLRVV 191
++E +M R+ + E + + RL+ + E + L+ + LQE + +
Sbjct: 1507 ----RQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQE-EISDL 1561
Query: 192 SAPLPRPGTS---LELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLV 248
+ + G S LE +KAL ++ SE +AL + + + + +Q L+ V
Sbjct: 1562 TDQVSLSGKSIQELEKTKKALEGEK----SEIQAALEEAEGALELEETKTLRIQLELSQV 1617
Query: 249 GKEGPQWLHVRDFD--RLLRESQREVLRLQRQI--ALRNQRETLPLPPSWPPG-PALQAR 303
E + L +D + L R QR V LQ + R + E L L L+ +
Sbjct: 1618 KAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQ 1677
Query: 304 AGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKK-RKKCESLEQEARKKQ 362
G A +AT + A L + + ++EQ + E L+ + ++ ++LE+ A
Sbjct: 1678 LGH----ATRQATEAQAATRL--MQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLA 1731
Query: 363 RRCEELELQLRQAQNENA----RLVEENSRLS-------GRATEKEQVEWENAELRGQLL 411
EEL L Q + L+E RL+ G +K+++E + A+L G++
Sbjct: 1732 AELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVE 1791
Query: 412 GVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRR 471
QER A K++ + + + LK ++ + ++++ EQ ++RE Q R
Sbjct: 1792 EAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQ---TVRELQA---R 1845
Query: 472 LQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLH 528
L++A+ A R + VQ LE A+VRELE + ++ ++ A+ L+ R H
Sbjct: 1846 LEEAEQAALRGGKKQVQKLE-------AKVRELEAELDAEQKKH---AEALKGVRKH 1892
Score = 60.5 bits (145), Expect = 2e-08
Identities = 89/408 (21%), Positives = 176/408 (43%), Gaps = 52/408 (12%)
Query: 130 LGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQE--TN 187
L + +RC +L + L + E E++ + NA+LA ++LE+ +L++ +
Sbjct: 947 LADAEERCHLLIKSKVQL-EGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDD 1005
Query: 188 LRVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTL 247
L++ A + K + ++L+E +AL D+ +A L +E + LQ
Sbjct: 1006 LKLTLAKAEK--------EKQATENKVKNLTEEMAAL---DESVARLTKEKKALQE---- 1050
Query: 248 VGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAP 307
H + L E R + ++ L Q E L +
Sbjct: 1051 --------AHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKR 1102
Query: 308 APGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCE-------SLEQEARK 360
+ T + AD + + E+++++ +SELS+ + E ++++ ++
Sbjct: 1103 KLEGDLKLTQESVAD---AAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKE 1159
Query: 361 KQRRCEELELQLRQAQNENARLVEENSRLSGRATE-KEQVEWENAELRGQLLGVTQERDS 419
Q R EELE +L + AR+ ++ + + E E++E GQ G ++R++
Sbjct: 1160 LQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREG-CRKREA 1218
Query: 420 ALRKSQGLQSKLESLEQVLKHMREVAQ-RRQQLEVEHEQARLSLREKQEEVRRLQQAQAE 478
L + L+ +LE E L+H VA RR+Q E E L E+ + ++R++Q +
Sbjct: 1219 ELGR---LRRELE--EAALRHEATVAALRRKQAEGAAE-----LGEQVDSLQRVRQKLEK 1268
Query: 479 AQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFS---LLAQELQ 523
+ E V L + ++++ E+ CR+ +Q S + +ELQ
Sbjct: 1269 EKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQ 1316
Score = 57.4 bits (137), Expect = 1e-07
Identities = 106/462 (22%), Positives = 180/462 (38%), Gaps = 89/462 (19%)
Query: 87 LGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGD-RPNLELL-RALGELRQRCAILKEEN 144
LG+Q S Q+ E E K++L M D N+E L RA + C +++
Sbjct: 1252 LGEQVDSLQRVRQKLEKE------KSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQ- 1304
Query: 145 QMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLEL 204
E + KV L+R+ A+ + RL+ + +L L + + L
Sbjct: 1305 -------LSEAKIKVEELQRQLADASTQRGRLQTESGELSRL-LEEKECLISQLSRGKAL 1356
Query: 205 CRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRL 264
++L R R L E + A A + AL+ +C L
Sbjct: 1357 AAQSLEELR-RQLEEESKAKSALAHAVQALRHDCD------------------------L 1391
Query: 265 LRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNL 324
LRE E Q ++ QR L ++A A A + + DA
Sbjct: 1392 LREQHEEEAEAQAEL----QR--------------LLSKANAEV--AQWRSKYEADAIQR 1431
Query: 325 PVILGEPEKEQ--RVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARL 382
L E +K+ R+Q+ E + KC SLE+ + Q E++ L+L +A + A L
Sbjct: 1432 TEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAAL 1491
Query: 383 VEENSRLS------GRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQ 436
++ L R E+ Q E E A+ + LG R G + LE+LE
Sbjct: 1492 DKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGT-----ELFRLRHGHEEALEALET 1546
Query: 437 VLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQ---REHEGAVQLLES- 492
+ + + + + L + + S++E ++ + L+ ++E Q E EGA++L E+
Sbjct: 1547 LKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETK 1606
Query: 493 ------TLDSMQARV----RELEEQCRSQTEQFSLLAQELQA 524
L ++A V E +E+C + + LQA
Sbjct: 1607 TLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQA 1648
Score = 52.4 bits (124), Expect = 4e-06
Identities = 98/455 (21%), Positives = 184/455 (40%), Gaps = 55/455 (12%)
Query: 102 EDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRR 161
++EEV A L A+ + EL + + +L+ A ++E Q TE KV+
Sbjct: 977 DEEEVNADLAARRRKL--EDECTELKKDIDDLKLTLAKAEKEKQA--------TENKVKN 1026
Query: 162 LKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQRARDLSETA 221
L + A L RL + + LQE + + + L + A+ R E
Sbjct: 1027 LTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTK---AKLRLEQQVEDL 1083
Query: 222 SALLAKDKQIAA-LQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIA 280
L ++K++ +R R+L+ L L + +D +L + +++ L Q++
Sbjct: 1084 ECSLEQEKKLRMDTERAKRKLEGDLKLTQESVAD--AAQDKQQLEEKLKKKDSELS-QLS 1140
Query: 281 LRNQRETLPLPPSWPPGPALQARAGAPAPGAPGE--ATPQEDADNLPVILGEPEKEQRVQ 338
LR + E L LQARA E A + + E +R++
Sbjct: 1141 LRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLE 1200
Query: 339 QLESELSKKRKKCESLEQEARKKQRRCEELELQ-------LRQAQNENARLVEENSRLSG 391
+ + +R+ C E E + +R EE L+ LR+ Q E A + E
Sbjct: 1201 EAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQ 1260
Query: 392 RA-----TEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLE----SLEQVLKHMR 442
R EK ++ E +L + +T+ + SA + + + +L +E++ + +
Sbjct: 1261 RVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLA 1320
Query: 443 EVAQRRQQLEVEHEQARLSLREKQ-----------------EEVRRLQQAQAEAQREHEG 485
+ + +R +L+ E + L EK+ EE+RR + +++A+
Sbjct: 1321 DASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAH 1380
Query: 486 AVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQ 520
AVQ L D ++ + EE+ +Q E LL++
Sbjct: 1381 AVQALRHDCDLLR---EQHEEEAEAQAELQRLLSK 1412
Score = 48.5 bits (114), Expect = 6e-05
Identities = 90/391 (23%), Positives = 157/391 (40%), Gaps = 65/391 (16%)
Query: 125 ELLRALGELRQRCAILKEENQM----LRKSSFPETE---EKVRRLKRKNAELAVIAKRLE 177
E+ R L E + CA L+ +Q L+ S ET E +R K+ +L + +L
Sbjct: 1620 EVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLG 1679
Query: 178 ERARKLQETNL--RVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQ 235
R+ E R++ A L E + ++ A +L E A AL +++ + L
Sbjct: 1680 HATRQATEAQAATRLMQAQLKE-----EQAGRDEEQRLAAELHEQAQAL---ERRASLLA 1731
Query: 236 RECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWP 295
E EL+A L ++G + + + LL ++R L + L NQ++ L
Sbjct: 1732 AELEELRAAL----EQGERSRRLAE-QELLEATERLNLLHSQNTGLLNQKKKLEAD---- 1782
Query: 296 PGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLE 355
L +G A +E A +E + +Q S ++ KK +LE
Sbjct: 1783 ----LAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK--TLE 1836
Query: 356 QEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQ 415
Q R+ Q R EE E + L G + +++E + EL +L
Sbjct: 1837 QTVRELQARLEEAE----------------QAALRGGKKQVQKLEAKVRELEAEL----- 1875
Query: 416 ERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQA 475
D+ +K + LK +R+ +R ++L + E+ R +L Q+ V +LQ
Sbjct: 1876 --DAEQKKHA----------EALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSK 1923
Query: 476 QAEAQREHEGAVQLLESTLDSMQARVRELEE 506
+R+ E A Q + L + EL++
Sbjct: 1924 VKSYKRQFEEAEQQANTNLAKYRKAQHELDD 1954
Score = 35.0 bits (79), Expect = 0.68
Identities = 31/148 (20%), Positives = 64/148 (43%), Gaps = 5/148 (3%)
Query: 370 LQLRQAQNENARLVEENSRLSGRATEKEQVEWE----NAELRGQLLGVTQERDSALRKSQ 425
L L QA++ + E RL G ++W NA + + + LR +Q
Sbjct: 834 LTLLQARSRGRLMRLEYQRLLGGRDALFTIQWNIRAFNAVKNWSWMKLFFKMKPLLRSAQ 893
Query: 426 GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEG 485
+ +L +L L+ +R + E E+ +S+ +++ ++ QA+ + + E
Sbjct: 894 A-EEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEE 952
Query: 486 AVQLLESTLDSMQARVRELEEQCRSQTE 513
LL + ++ +V+EL E+ + E
Sbjct: 953 RCHLLIKSKVQLEGKVKELSERLEDEEE 980
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.131 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,844,081
Number of Sequences: 37866
Number of extensions: 6318866
Number of successful extensions: 78528
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 744
Number of HSP's successfully gapped in prelim test: 2710
Number of HSP's that attempted gapping in prelim test: 36599
Number of HSP's gapped (non-prelim): 30759
length of query: 1857
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1740
effective length of database: 13,817,196
effective search space: 24041921040
effective search space used: 24041921040
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.