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Search of human proteins with 169202933
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169202933 PREDICTED: similar to hCG21066 [Homo sapiens]
(451 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169202933 PREDICTED: similar to hCG21066 [Homo sapiens] 939 0.0
gi|169203543 PREDICTED: similar to hCG21066 [Homo sapiens] 939 0.0
gi|239744413 PREDICTED: hypothetical protein LOC390213 [Homo sap... 455 e-128
gi|47078261 double C2-like domains, alpha [Homo sapiens] 317 1e-86
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens] 197 2e-50
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens] 197 2e-50
gi|6005997 double C2-like domains, beta [Homo sapiens] 191 2e-48
gi|211059429 synaptotagmin II [Homo sapiens] 102 7e-22
gi|31543670 synaptotagmin II [Homo sapiens] 102 7e-22
gi|209447073 synaptotagmin I [Homo sapiens] 100 4e-21
gi|5032139 synaptotagmin I [Homo sapiens] 100 4e-21
gi|209447070 synaptotagmin I [Homo sapiens] 100 4e-21
gi|45504376 synaptotagmin VI [Homo sapiens] 99 6e-21
gi|238550198 synaptotagmin III [Homo sapiens] 93 4e-19
gi|238550196 synaptotagmin III [Homo sapiens] 93 4e-19
gi|14150054 synaptotagmin III [Homo sapiens] 93 4e-19
gi|39752671 synaptotagmin X [Homo sapiens] 93 6e-19
gi|92859638 synaptotagmin V [Homo sapiens] 91 2e-18
gi|150170670 piccolo isoform 2 [Homo sapiens] 91 2e-18
gi|150378539 piccolo isoform 1 [Homo sapiens] 91 2e-18
gi|38570146 synaptotagmin VII [Homo sapiens] 91 2e-18
gi|28376627 synaptotagmin IX [Homo sapiens] 90 4e-18
gi|40068038 B/K protein [Homo sapiens] 87 3e-17
gi|24308219 synaptotagmin IV [Homo sapiens] 85 2e-16
gi|94536846 synaptotagmin VIII [Homo sapiens] 82 8e-16
gi|45387945 family with sequence similarity 62 (C2 domain contai... 78 1e-14
gi|193804862 synaptotagmin-like 4 [Homo sapiens] 77 3e-14
gi|193804860 synaptotagmin-like 4 [Homo sapiens] 77 3e-14
gi|4506067 protein kinase C, alpha [Homo sapiens] 73 6e-13
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 72 8e-13
>gi|169202933 PREDICTED: similar to hCG21066 [Homo sapiens]
Length = 451
Score = 939 bits (2427), Expect = 0.0
Identities = 451/451 (100%), Positives = 451/451 (100%)
Query: 1 MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA 60
MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA
Sbjct: 1 MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA 60
Query: 61 SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD 120
SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD
Sbjct: 61 SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD 120
Query: 121 AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC 180
AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC
Sbjct: 121 AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC 180
Query: 181 VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLAKRPKSLDTACGMSLYEV 240
VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLAKRPKSLDTACGMSLYEV
Sbjct: 181 VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLAKRPKSLDTACGMSLYEV 240
Query: 241 VPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPSAPDPKHNSARSMEEVE 300
VPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPSAPDPKHNSARSMEEVE
Sbjct: 241 VPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPSAPDPKHNSARSMEEVE 300
Query: 301 TEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSK 360
TEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSK
Sbjct: 301 TEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSK 360
Query: 361 FKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGE 420
FKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGE
Sbjct: 361 FKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGE 420
Query: 421 RLRHWLECLGHSDHRLELWHPLDSKPVQLSD 451
RLRHWLECLGHSDHRLELWHPLDSKPVQLSD
Sbjct: 421 RLRHWLECLGHSDHRLELWHPLDSKPVQLSD 451
>gi|169203543 PREDICTED: similar to hCG21066 [Homo sapiens]
Length = 451
Score = 939 bits (2427), Expect = 0.0
Identities = 451/451 (100%), Positives = 451/451 (100%)
Query: 1 MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA 60
MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA
Sbjct: 1 MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA 60
Query: 61 SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD 120
SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD
Sbjct: 61 SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD 120
Query: 121 AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC 180
AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC
Sbjct: 121 AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC 180
Query: 181 VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLAKRPKSLDTACGMSLYEV 240
VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLAKRPKSLDTACGMSLYEV
Sbjct: 181 VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLAKRPKSLDTACGMSLYEV 240
Query: 241 VPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPSAPDPKHNSARSMEEVE 300
VPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPSAPDPKHNSARSMEEVE
Sbjct: 241 VPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPSAPDPKHNSARSMEEVE 300
Query: 301 TEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSK 360
TEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSK
Sbjct: 301 TEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSK 360
Query: 361 FKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGE 420
FKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGE
Sbjct: 361 FKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGE 420
Query: 421 RLRHWLECLGHSDHRLELWHPLDSKPVQLSD 451
RLRHWLECLGHSDHRLELWHPLDSKPVQLSD
Sbjct: 421 RLRHWLECLGHSDHRLELWHPLDSKPVQLSD 451
>gi|239744413 PREDICTED: hypothetical protein LOC390213 [Homo
sapiens]
Length = 431
Score = 455 bits (1171), Expect = e-128
Identities = 222/222 (100%), Positives = 222/222 (100%)
Query: 1 MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA 60
MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA
Sbjct: 55 MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA 114
Query: 61 SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD 120
SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD
Sbjct: 115 SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD 174
Query: 121 AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC 180
AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC
Sbjct: 175 AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC 234
Query: 181 VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRL 222
VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRL
Sbjct: 235 VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRL 276
Score = 329 bits (844), Expect = 3e-90
Identities = 155/158 (98%), Positives = 157/158 (99%)
Query: 294 RSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP 353
R +EEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP
Sbjct: 274 RRLEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP 333
Query: 354 NAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
NAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL
Sbjct: 334 NAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 393
Query: 414 GSHASGERLRHWLECLGHSDHRLELWHPLDSKPVQLSD 451
GSHASGERLRHWLECLGHSDHRL+LWHPLDSKPVQLSD
Sbjct: 394 GSHASGERLRHWLECLGHSDHRLKLWHPLDSKPVQLSD 431
Score = 35.4 bits (80), Expect = 0.11
Identities = 31/114 (27%), Positives = 50/114 (43%), Gaps = 12/114 (10%)
Query: 280 PRVPSAPDPKHNSARSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDA 339
P++ P+P+ +S S G + +L + + L R L P+ A
Sbjct: 121 PQLQPDPEPEGDSDDSTA----------LGTLEFTLLFEADNSALHCTAHRAKGLKPL-A 169
Query: 340 NGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSG-PREELAQKTL 392
+G +D +V+ L P A K S+ +T R T P + E Y G R++ KTL
Sbjct: 170 SGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTL 223
Score = 35.0 bits (79), Expect = 0.14
Identities = 26/85 (30%), Positives = 40/85 (47%), Gaps = 2/85 (2%)
Query: 86 GTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQLRTHTVRG 144
G + +L + + L R L P+ A+G +D +V+ L P A K S+ +T R
Sbjct: 289 GHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRK 348
Query: 145 TRVPVWEETLTYHGFTRQDAECKTL 169
T P + E Y G R++ KTL
Sbjct: 349 TLNPEFNEEFFYSG-PREELAQKTL 372
>gi|47078261 double C2-like domains, alpha [Homo sapiens]
Length = 400
Score = 317 bits (813), Expect = 1e-86
Identities = 199/449 (44%), Positives = 251/449 (55%), Gaps = 77/449 (17%)
Query: 9 GQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAE---------PA-LHPPNLRPA 58
G +++QEHMAI+V PGPIRPIR IS YFP P E PA L P L P
Sbjct: 6 GDRMTINIQEHMAINVCPGPIRPIRQISDYFPRG-PGPEGGGGGGGEAPAHLVPLALAPP 64
Query: 59 AASAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLA-SG 117
AA + P+ + + DSDD+TALGTLEF LL++ + LHC+ RAKGLKP+ +G
Sbjct: 65 AALLGATTPEDGAEVDSY-DSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNG 123
Query: 118 SADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQ 177
AD YVK +LLPGA KA++L+T T R T PVW E LTY G T D K LR
Sbjct: 124 LADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRI------ 177
Query: 178 AVCVRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLAKRPKSLDTACGMSL 237
AVC + ++ +GE+RVPLR+L P++ + F+ICLE++ P S+
Sbjct: 178 AVCDEDKLSHNEF----IGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSA------ 227
Query: 238 YEVVPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPSAPDPKHNSARSME 297
A SC L + +E
Sbjct: 228 ------------ALRGISCYL-----------------------------------KELE 240
Query: 298 EVET-EVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAG 356
+ E + EE G +LLSL YSS++ GLLVG+LRCAHLA MD NGYSDP+V+ +L P+
Sbjct: 241 QAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVD 300
Query: 357 KKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSH 416
KKSK KT V +KTLNPEFNEEFFY LA KTL V+VWDYD+G ++DFIGGV LG
Sbjct: 301 KKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPG 360
Query: 417 ASGERLRHWLECLGHSDHRLELWHPLDSK 445
A GE +HW +CL D LE WH L S+
Sbjct: 361 ARGEARKHWSDCLQQPDAALERWHTLTSE 389
>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
Length = 694
Score = 197 bits (500), Expect = 2e-50
Identities = 95/165 (57%), Positives = 122/165 (73%), Gaps = 5/165 (3%)
Query: 292 SARSM-----EEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPF 346
SAR M E+VE EE G +L+SL YS+QQGGL+VG++RC HLA MDANGYSDPF
Sbjct: 530 SARGMALYEEEQVERVGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPF 589
Query: 347 VRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADD 406
V+L+L P+ GKK+K KT + +KTLNPEFNEEFFY +LA+K+L +SVWDYD+G ++D
Sbjct: 590 VKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSND 649
Query: 407 FIGGVQLGSHASGERLRHWLECLGHSDHRLELWHPLDSKPVQLSD 451
+IGG QLG A GERL+HW ECL + D ++E WH L ++ SD
Sbjct: 650 YIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQNENHVSSD 694
Score = 154 bits (390), Expect = 1e-37
Identities = 91/198 (45%), Positives = 125/198 (63%), Gaps = 19/198 (9%)
Query: 51 HP--PNLRPAAASAVRSAPQLQPDPEPEG------DSDDSTALGTLEFTLLFEADNSALH 102
HP P + +AA+ +A + P PE E DSD++T LG LEF+LL++ DNS+L
Sbjct: 351 HPSGPYSQASAAAPQPAAARQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQ 410
Query: 103 CTAHRAKGLKPLAS-GSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTR 161
CT +AKGLKP+ S G AD YVK +LLPGASK+++LRT T+R TR P+W ETL YHG T
Sbjct: 411 CTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITD 470
Query: 162 QDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRR 221
+D + KTLR +VC ++ +GE R L+KL PN+ ++F+ICLE+
Sbjct: 471 EDMQRKTLRI------SVCDEDKFGHNEF----IGETRFSLKKLKPNQRKNFNICLERVI 520
Query: 222 LAKRPKSLDTACGMSLYE 239
KR + +A GM+LYE
Sbjct: 521 PMKRAGTTGSARGMALYE 538
Score = 78.2 bits (191), Expect = 1e-14
Identities = 46/130 (35%), Positives = 66/130 (50%), Gaps = 5/130 (3%)
Query: 281 RVPSAPDPKHNSARSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDAN 340
R P P+ + A S + E G + SL Y L +++ L PMD+N
Sbjct: 370 RQPPPPEEEEEEANSYDSDEATTL----GALEFSLLYDQDNSSLQCTIIKAKGLKPMDSN 425
Query: 341 GYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSG-PREELAQKTLLVSVWDY 399
G +DP+V+L L P A K +K +T R T NP +NE Y G E++ +KTL +SV D
Sbjct: 426 GLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDE 485
Query: 400 DLGTADDFIG 409
D ++FIG
Sbjct: 486 DKFGHNEFIG 495
>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
Length = 690
Score = 197 bits (500), Expect = 2e-50
Identities = 95/165 (57%), Positives = 122/165 (73%), Gaps = 5/165 (3%)
Query: 292 SARSM-----EEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPF 346
SAR M E+VE EE G +L+SL YS+QQGGL+VG++RC HLA MDANGYSDPF
Sbjct: 526 SARGMALYEEEQVERVGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPF 585
Query: 347 VRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADD 406
V+L+L P+ GKK+K KT + +KTLNPEFNEEFFY +LA+K+L +SVWDYD+G ++D
Sbjct: 586 VKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSND 645
Query: 407 FIGGVQLGSHASGERLRHWLECLGHSDHRLELWHPLDSKPVQLSD 451
+IGG QLG A GERL+HW ECL + D ++E WH L ++ SD
Sbjct: 646 YIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQNENHVSSD 690
Score = 154 bits (390), Expect = 1e-37
Identities = 91/198 (45%), Positives = 125/198 (63%), Gaps = 19/198 (9%)
Query: 51 HP--PNLRPAAASAVRSAPQLQPDPEPEG------DSDDSTALGTLEFTLLFEADNSALH 102
HP P + +AA+ +A + P PE E DSD++T LG LEF+LL++ DNS+L
Sbjct: 347 HPSGPYSQASAAAPQPAAARQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQ 406
Query: 103 CTAHRAKGLKPLAS-GSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTR 161
CT +AKGLKP+ S G AD YVK +LLPGASK+++LRT T+R TR P+W ETL YHG T
Sbjct: 407 CTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITD 466
Query: 162 QDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRR 221
+D + KTLR +VC ++ +GE R L+KL PN+ ++F+ICLE+
Sbjct: 467 EDMQRKTLRI------SVCDEDKFGHNEF----IGETRFSLKKLKPNQRKNFNICLERVI 516
Query: 222 LAKRPKSLDTACGMSLYE 239
KR + +A GM+LYE
Sbjct: 517 PMKRAGTTGSARGMALYE 534
Score = 78.2 bits (191), Expect = 1e-14
Identities = 46/130 (35%), Positives = 66/130 (50%), Gaps = 5/130 (3%)
Query: 281 RVPSAPDPKHNSARSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDAN 340
R P P+ + A S + E G + SL Y L +++ L PMD+N
Sbjct: 366 RQPPPPEEEEEEANSYDSDEATTL----GALEFSLLYDQDNSSLQCTIIKAKGLKPMDSN 421
Query: 341 GYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSG-PREELAQKTLLVSVWDY 399
G +DP+V+L L P A K +K +T R T NP +NE Y G E++ +KTL +SV D
Sbjct: 422 GLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDE 481
Query: 400 DLGTADDFIG 409
D ++FIG
Sbjct: 482 DKFGHNEFIG 491
>gi|6005997 double C2-like domains, beta [Homo sapiens]
Length = 412
Score = 191 bits (484), Expect = 2e-48
Identities = 88/140 (62%), Positives = 111/140 (79%)
Query: 306 EECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSV 365
EE G +L+SL YSSQ+ GLLVG++RCAHLA MDANGYSDP+V+ +L P+ KKSK KT+V
Sbjct: 265 EERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAV 324
Query: 366 HRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHW 425
+KTLNPEFNEEF Y +LA+K+L V+VWDYD+G ++DFIGGV LG HA GERL+HW
Sbjct: 325 KKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHW 384
Query: 426 LECLGHSDHRLELWHPLDSK 445
+CL + D R+E WH L S+
Sbjct: 385 FDCLKNKDKRIERWHTLTSE 404
Score = 184 bits (467), Expect = 1e-46
Identities = 116/257 (45%), Positives = 148/257 (57%), Gaps = 55/257 (21%)
Query: 9 GQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHF----YPFAEP-ALHPPN--LRPAAAS 61
G+ +S+QEHMAIDV PGPIRPI+ IS YFP F P A P A PP+ RPA A
Sbjct: 7 GEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPARPAVAG 66
Query: 62 AVRSAPQ----------------------------------LQPDPEPEGD---SDDSTA 84
A R +P P+ EP+ D SDD TA
Sbjct: 67 AGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYESDDCTA 126
Query: 85 LGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQLRTHTVR 143
LGTL+F+LL++ +N+ALHCT +AKGLKP+ +G AD YVK +LLPGASKA++LRT T+R
Sbjct: 127 LGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLR 186
Query: 144 GTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSLGELRVPLR 203
T P W ETLTY+G T +D KTLR +VC ++ +GE RVPL+
Sbjct: 187 NTLNPTWNETLTYYGITDEDMIRKTLRI------SVCDEDKFRHNEF----IGETRVPLK 236
Query: 204 KLVPNRARSFDICLEKR 220
KL PN ++F+ICLEK+
Sbjct: 237 KLKPNHTKTFNICLEKQ 253
Score = 75.5 bits (184), Expect = 9e-14
Identities = 48/136 (35%), Positives = 68/136 (50%), Gaps = 6/136 (4%)
Query: 280 PRVPSAPDPKHNSARSMEEVETEVAWE--EC---GHVLLSLCYSSQQGGLLVGVLRCAHL 334
P P P A+ E+ +E +C G + SL Y + L + + L
Sbjct: 94 PGPSPGPSPARPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGL 153
Query: 335 APMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSG-PREELAQKTLL 393
PMD NG +DP+V+L L P A K +K +T R TLNP +NE Y G E++ +KTL
Sbjct: 154 KPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLR 213
Query: 394 VSVWDYDLGTADDFIG 409
+SV D D ++FIG
Sbjct: 214 ISVCDEDKFRHNEFIG 229
Score = 28.9 bits (63), Expect = 10.0
Identities = 20/64 (31%), Positives = 29/64 (45%), Gaps = 4/64 (6%)
Query: 115 ASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTY---HG-FTRQDAECKTLR 170
A+G +D YVK L P K S+ +T + T P + E Y HG ++ E
Sbjct: 298 ANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWD 357
Query: 171 SDLG 174
D+G
Sbjct: 358 YDIG 361
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 102 bits (254), Expect = 7e-22
Identities = 53/137 (38%), Positives = 79/137 (57%)
Query: 306 EECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSV 365
E+ G + SL Y G L V +L +L MD G SDP+V++ L N + K KT+V
Sbjct: 269 EKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTV 328
Query: 366 HRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHW 425
+KTLNP FNE F + P E++ + ++V+V DYD ++ IG + +GS+A+G LRHW
Sbjct: 329 KKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHW 388
Query: 426 LECLGHSDHRLELWHPL 442
+ L + + WH L
Sbjct: 389 SDMLANPRRPIAQWHSL 405
Score = 100 bits (249), Expect = 3e-21
Identities = 56/135 (41%), Positives = 80/135 (59%), Gaps = 4/135 (2%)
Query: 298 EVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGK 357
E E E E G + SL Y Q L VGVL+ A L +D G SDP+V++FL P+ K
Sbjct: 130 EGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPD--K 187
Query: 358 KSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHA 417
K K++T VHRKTLNP FNE F + P +EL KTL+++++D+D + D IG V++ +
Sbjct: 188 KKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNT 247
Query: 418 --SGERLRHWLECLG 430
G+ + W + G
Sbjct: 248 VDLGQPIEEWRDLQG 262
Score = 38.5 bits (88), Expect = 0.013
Identities = 38/131 (29%), Positives = 59/131 (45%), Gaps = 15/131 (11%)
Query: 74 EPEGDSD-DSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGA 131
E EG+ + + LG L+F+L ++ + L +A L L G++D YVK LLP
Sbjct: 128 EGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDK 187
Query: 132 SKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQ 191
K + + H R T P + ET T+ K +LGG V R +
Sbjct: 188 KKKYETKVH--RKTLNPAFNETFTF----------KVPYQELGGKTLVMAIYDF-DRFSK 234
Query: 192 APSLGELRVPL 202
+GE++VP+
Sbjct: 235 HDIIGEVKVPM 245
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 102 bits (254), Expect = 7e-22
Identities = 53/137 (38%), Positives = 79/137 (57%)
Query: 306 EECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSV 365
E+ G + SL Y G L V +L +L MD G SDP+V++ L N + K KT+V
Sbjct: 269 EKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTV 328
Query: 366 HRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHW 425
+KTLNP FNE F + P E++ + ++V+V DYD ++ IG + +GS+A+G LRHW
Sbjct: 329 KKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHW 388
Query: 426 LECLGHSDHRLELWHPL 442
+ L + + WH L
Sbjct: 389 SDMLANPRRPIAQWHSL 405
Score = 100 bits (249), Expect = 3e-21
Identities = 56/135 (41%), Positives = 80/135 (59%), Gaps = 4/135 (2%)
Query: 298 EVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGK 357
E E E E G + SL Y Q L VGVL+ A L +D G SDP+V++FL P+ K
Sbjct: 130 EGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPD--K 187
Query: 358 KSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHA 417
K K++T VHRKTLNP FNE F + P +EL KTL+++++D+D + D IG V++ +
Sbjct: 188 KKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNT 247
Query: 418 --SGERLRHWLECLG 430
G+ + W + G
Sbjct: 248 VDLGQPIEEWRDLQG 262
Score = 38.5 bits (88), Expect = 0.013
Identities = 38/131 (29%), Positives = 59/131 (45%), Gaps = 15/131 (11%)
Query: 74 EPEGDSD-DSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGA 131
E EG+ + + LG L+F+L ++ + L +A L L G++D YVK LLP
Sbjct: 128 EGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDK 187
Query: 132 SKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQ 191
K + + H R T P + ET T+ K +LGG V R +
Sbjct: 188 KKKYETKVH--RKTLNPAFNETFTF----------KVPYQELGGKTLVMAIYDF-DRFSK 234
Query: 192 APSLGELRVPL 202
+GE++VP+
Sbjct: 235 HDIIGEVKVPM 245
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 100 bits (248), Expect = 4e-21
Identities = 53/113 (46%), Positives = 72/113 (63%), Gaps = 2/113 (1%)
Query: 297 EEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAG 356
EE E E+ G + SL Y Q LLVG+++ A L +D G SDP+V++FL P+
Sbjct: 132 EEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPD-- 189
Query: 357 KKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIG 409
KK KF+T VHRKTLNP FNE+F + P EL KTL+++V+D+D + D IG
Sbjct: 190 KKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIG 242
Score = 99.4 bits (246), Expect = 6e-21
Identities = 53/149 (35%), Positives = 82/149 (55%), Gaps = 1/149 (0%)
Query: 294 RSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP 353
R ++ E E E+ G + SL Y G L V +L +L MD G SDP+V++ L
Sbjct: 261 RDLQSAEKEEQ-EKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQ 319
Query: 354 NAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
N + K KT++ + TLNP +NE F + P E++ + ++V+V DYD +D IG V +
Sbjct: 320 NGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFV 379
Query: 414 GSHASGERLRHWLECLGHSDHRLELWHPL 442
G +++G LRHW + L + + WH L
Sbjct: 380 GYNSTGAELRHWSDMLANPRRPIAQWHTL 408
Score = 41.2 bits (95), Expect = 0.002
Identities = 38/132 (28%), Positives = 59/132 (44%), Gaps = 14/132 (10%)
Query: 72 DPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPG 130
D E + + + LG L+++L ++ N+ L +A L L G++D YVK LLP
Sbjct: 130 DGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPD 189
Query: 131 ASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQW 190
K + + H R T PV+ E T+ K S+LGG V R
Sbjct: 190 KKKKFETKVH--RKTLNPVFNEQFTF----------KVPYSELGGKTLVMAVYDF-DRFS 236
Query: 191 QAPSLGELRVPL 202
+ +GE +VP+
Sbjct: 237 KHDIIGEFKVPM 248
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 100 bits (248), Expect = 4e-21
Identities = 53/113 (46%), Positives = 72/113 (63%), Gaps = 2/113 (1%)
Query: 297 EEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAG 356
EE E E+ G + SL Y Q LLVG+++ A L +D G SDP+V++FL P+
Sbjct: 132 EEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPD-- 189
Query: 357 KKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIG 409
KK KF+T VHRKTLNP FNE+F + P EL KTL+++V+D+D + D IG
Sbjct: 190 KKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIG 242
Score = 99.4 bits (246), Expect = 6e-21
Identities = 53/149 (35%), Positives = 82/149 (55%), Gaps = 1/149 (0%)
Query: 294 RSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP 353
R ++ E E E+ G + SL Y G L V +L +L MD G SDP+V++ L
Sbjct: 261 RDLQSAEKEEQ-EKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQ 319
Query: 354 NAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
N + K KT++ + TLNP +NE F + P E++ + ++V+V DYD +D IG V +
Sbjct: 320 NGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFV 379
Query: 414 GSHASGERLRHWLECLGHSDHRLELWHPL 442
G +++G LRHW + L + + WH L
Sbjct: 380 GYNSTGAELRHWSDMLANPRRPIAQWHTL 408
Score = 41.2 bits (95), Expect = 0.002
Identities = 38/132 (28%), Positives = 59/132 (44%), Gaps = 14/132 (10%)
Query: 72 DPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPG 130
D E + + + LG L+++L ++ N+ L +A L L G++D YVK LLP
Sbjct: 130 DGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPD 189
Query: 131 ASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQW 190
K + + H R T PV+ E T+ K S+LGG V R
Sbjct: 190 KKKKFETKVH--RKTLNPVFNEQFTF----------KVPYSELGGKTLVMAVYDF-DRFS 236
Query: 191 QAPSLGELRVPL 202
+ +GE +VP+
Sbjct: 237 KHDIIGEFKVPM 248
>gi|209447070 synaptotagmin I [Homo sapiens]
Length = 422
Score = 100 bits (248), Expect = 4e-21
Identities = 53/113 (46%), Positives = 72/113 (63%), Gaps = 2/113 (1%)
Query: 297 EEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAG 356
EE E E+ G + SL Y Q LLVG+++ A L +D G SDP+V++FL P+
Sbjct: 132 EEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPD-- 189
Query: 357 KKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIG 409
KK KF+T VHRKTLNP FNE+F + P EL KTL+++V+D+D + D IG
Sbjct: 190 KKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIG 242
Score = 99.4 bits (246), Expect = 6e-21
Identities = 53/149 (35%), Positives = 82/149 (55%), Gaps = 1/149 (0%)
Query: 294 RSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP 353
R ++ E E E+ G + SL Y G L V +L +L MD G SDP+V++ L
Sbjct: 261 RDLQSAEKEEQ-EKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQ 319
Query: 354 NAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
N + K KT++ + TLNP +NE F + P E++ + ++V+V DYD +D IG V +
Sbjct: 320 NGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFV 379
Query: 414 GSHASGERLRHWLECLGHSDHRLELWHPL 442
G +++G LRHW + L + + WH L
Sbjct: 380 GYNSTGAELRHWSDMLANPRRPIAQWHTL 408
Score = 41.2 bits (95), Expect = 0.002
Identities = 38/132 (28%), Positives = 59/132 (44%), Gaps = 14/132 (10%)
Query: 72 DPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPG 130
D E + + + LG L+++L ++ N+ L +A L L G++D YVK LLP
Sbjct: 130 DGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPD 189
Query: 131 ASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQW 190
K + + H R T PV+ E T+ K S+LGG V R
Sbjct: 190 KKKKFETKVH--RKTLNPVFNEQFTF----------KVPYSELGGKTLVMAVYDF-DRFS 236
Query: 191 QAPSLGELRVPL 202
+ +GE +VP+
Sbjct: 237 KHDIIGEFKVPM 248
>gi|45504376 synaptotagmin VI [Homo sapiens]
Length = 425
Score = 99.4 bits (246), Expect = 6e-21
Identities = 50/136 (36%), Positives = 76/136 (55%)
Query: 307 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVH 366
+ G ++ SLCY G L + V++C +L MD GYSDP+V++ L + + K KT++
Sbjct: 276 DLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIK 335
Query: 367 RKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWL 426
+ TLNP +NE + P E + Q +LL+SV DYD ++ IG ++G A G HW
Sbjct: 336 KNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIGVCRVGITAEGLGRDHWN 395
Query: 427 ECLGHSDHRLELWHPL 442
E L + + WH L
Sbjct: 396 EMLAYPRKPIAHWHSL 411
Score = 85.9 bits (211), Expect = 7e-17
Identities = 49/117 (41%), Positives = 72/117 (61%), Gaps = 3/117 (2%)
Query: 297 EEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAG 356
E+ ++E A + CG + SL Y + L+V +L+ L D G SDP+V+++L P+
Sbjct: 135 EDAKSE-ATKSCGKINFSLRYDYETETLIVRILKAFDLPAKDFCGSSDPYVKIYLLPD-- 191
Query: 357 KKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
+K K +T VHRKTLNP F+E F + P EELA + L +SV+D+D + D IG V L
Sbjct: 192 RKCKLQTRVHRKTLNPTFDENFHFPVPYEELADRKLHLSVFDFDRFSRHDMIGEVIL 248
Score = 35.4 bits (80), Expect = 0.11
Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 1/79 (1%)
Query: 79 SDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQL 137
+ +S LG + F+L + L T + + LK + +G +D YVK +LL + +
Sbjct: 271 TSESVDLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKK 330
Query: 138 RTHTVRGTRVPVWEETLTY 156
+T + T PV+ E + +
Sbjct: 331 KTTIKKNTLNPVYNEAIIF 349
Score = 33.5 bits (75), Expect = 0.40
Identities = 32/109 (29%), Positives = 48/109 (44%), Gaps = 9/109 (8%)
Query: 55 LRPAA---ASAVRSAPQLQPDPEPEGD---SDDSTALGTLEFTLLFEADNSALHCTAHRA 108
L PAA S R P+L +G+ S+ + + G + F+L ++ + L +A
Sbjct: 109 LPPAAEQPTSIGRIKPELYKQKSVDGEDAKSEATKSCGKINFSLRYDYETETLIVRILKA 168
Query: 109 KGLKPLA-SGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTY 156
L GS+D YVK LLP Q R H R T P ++E +
Sbjct: 169 FDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVH--RKTLNPTFDENFHF 215
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 93.2 bits (230), Expect = 4e-19
Identities = 49/106 (46%), Positives = 68/106 (64%), Gaps = 2/106 (1%)
Query: 308 CGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHR 367
CG + +L Y L+V +L+ L D+NG+SDP+V+++L P+ +K KF+T VHR
Sbjct: 300 CGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPD--RKKKFQTKVHR 357
Query: 368 KTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
KTLNP FNE F +S P ELAQ+ L SV+D+D + D IG V L
Sbjct: 358 KTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVL 403
Score = 83.2 bits (204), Expect = 4e-16
Identities = 46/137 (33%), Positives = 71/137 (51%), Gaps = 1/137 (0%)
Query: 307 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVH 366
+ G + SLCY G L V +++ ++L MD G+SDP+V+ L + K KTS+
Sbjct: 431 DLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIK 490
Query: 367 RKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLR-HW 425
+ TLNP +NE + E + L ++V DYD ++ IG ++G A+ R HW
Sbjct: 491 KNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHW 550
Query: 426 LECLGHSDHRLELWHPL 442
E L + +E WH L
Sbjct: 551 AEMLANPRKPVEHWHQL 567
Score = 37.7 bits (86), Expect = 0.021
Identities = 25/82 (30%), Positives = 41/82 (50%), Gaps = 2/82 (2%)
Query: 76 EGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKA 134
EG S+ + LG L F+L + L T +A LK + +G +D YVKA+L+ +
Sbjct: 424 EGGSEKAD-LGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRL 482
Query: 135 SQLRTHTVRGTRVPVWEETLTY 156
+ +T + T P + E L +
Sbjct: 483 KKRKTSIKKNTLNPTYNEALVF 504
Score = 31.6 bits (70), Expect = 1.5
Identities = 25/81 (30%), Positives = 35/81 (43%), Gaps = 3/81 (3%)
Query: 77 GDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLAS-GSADAYVKANLLPGASKAS 135
G++ G + F L + + L +A L S G +D YVK LLP K
Sbjct: 292 GEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKF 351
Query: 136 QLRTHTVRGTRVPVWEETLTY 156
Q + H R T PV+ ET +
Sbjct: 352 QTKVH--RKTLNPVFNETFQF 370
>gi|238550196 synaptotagmin III [Homo sapiens]
Length = 590
Score = 93.2 bits (230), Expect = 4e-19
Identities = 49/106 (46%), Positives = 68/106 (64%), Gaps = 2/106 (1%)
Query: 308 CGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHR 367
CG + +L Y L+V +L+ L D+NG+SDP+V+++L P+ +K KF+T VHR
Sbjct: 300 CGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPD--RKKKFQTKVHR 357
Query: 368 KTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
KTLNP FNE F +S P ELAQ+ L SV+D+D + D IG V L
Sbjct: 358 KTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVL 403
Score = 83.2 bits (204), Expect = 4e-16
Identities = 46/137 (33%), Positives = 71/137 (51%), Gaps = 1/137 (0%)
Query: 307 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVH 366
+ G + SLCY G L V +++ ++L MD G+SDP+V+ L + K KTS+
Sbjct: 431 DLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIK 490
Query: 367 RKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLR-HW 425
+ TLNP +NE + E + L ++V DYD ++ IG ++G A+ R HW
Sbjct: 491 KNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHW 550
Query: 426 LECLGHSDHRLELWHPL 442
E L + +E WH L
Sbjct: 551 AEMLANPRKPVEHWHQL 567
Score = 37.7 bits (86), Expect = 0.021
Identities = 25/82 (30%), Positives = 41/82 (50%), Gaps = 2/82 (2%)
Query: 76 EGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKA 134
EG S+ + LG L F+L + L T +A LK + +G +D YVKA+L+ +
Sbjct: 424 EGGSEKAD-LGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRL 482
Query: 135 SQLRTHTVRGTRVPVWEETLTY 156
+ +T + T P + E L +
Sbjct: 483 KKRKTSIKKNTLNPTYNEALVF 504
Score = 31.6 bits (70), Expect = 1.5
Identities = 25/81 (30%), Positives = 35/81 (43%), Gaps = 3/81 (3%)
Query: 77 GDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLAS-GSADAYVKANLLPGASKAS 135
G++ G + F L + + L +A L S G +D YVK LLP K
Sbjct: 292 GEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKF 351
Query: 136 QLRTHTVRGTRVPVWEETLTY 156
Q + H R T PV+ ET +
Sbjct: 352 QTKVH--RKTLNPVFNETFQF 370
>gi|14150054 synaptotagmin III [Homo sapiens]
Length = 590
Score = 93.2 bits (230), Expect = 4e-19
Identities = 49/106 (46%), Positives = 68/106 (64%), Gaps = 2/106 (1%)
Query: 308 CGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHR 367
CG + +L Y L+V +L+ L D+NG+SDP+V+++L P+ +K KF+T VHR
Sbjct: 300 CGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPD--RKKKFQTKVHR 357
Query: 368 KTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
KTLNP FNE F +S P ELAQ+ L SV+D+D + D IG V L
Sbjct: 358 KTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVL 403
Score = 83.2 bits (204), Expect = 4e-16
Identities = 46/137 (33%), Positives = 71/137 (51%), Gaps = 1/137 (0%)
Query: 307 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVH 366
+ G + SLCY G L V +++ ++L MD G+SDP+V+ L + K KTS+
Sbjct: 431 DLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIK 490
Query: 367 RKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLR-HW 425
+ TLNP +NE + E + L ++V DYD ++ IG ++G A+ R HW
Sbjct: 491 KNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHW 550
Query: 426 LECLGHSDHRLELWHPL 442
E L + +E WH L
Sbjct: 551 AEMLANPRKPVEHWHQL 567
Score = 37.7 bits (86), Expect = 0.021
Identities = 25/82 (30%), Positives = 41/82 (50%), Gaps = 2/82 (2%)
Query: 76 EGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKA 134
EG S+ + LG L F+L + L T +A LK + +G +D YVKA+L+ +
Sbjct: 424 EGGSEKAD-LGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRL 482
Query: 135 SQLRTHTVRGTRVPVWEETLTY 156
+ +T + T P + E L +
Sbjct: 483 KKRKTSIKKNTLNPTYNEALVF 504
Score = 31.6 bits (70), Expect = 1.5
Identities = 25/81 (30%), Positives = 35/81 (43%), Gaps = 3/81 (3%)
Query: 77 GDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLAS-GSADAYVKANLLPGASKAS 135
G++ G + F L + + L +A L S G +D YVK LLP K
Sbjct: 292 GEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKF 351
Query: 136 QLRTHTVRGTRVPVWEETLTY 156
Q + H R T PV+ ET +
Sbjct: 352 QTKVH--RKTLNPVFNETFQF 370
>gi|39752671 synaptotagmin X [Homo sapiens]
Length = 523
Score = 92.8 bits (229), Expect = 6e-19
Identities = 48/140 (34%), Positives = 73/140 (52%)
Query: 307 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVH 366
+ G ++ SLCY G + + V++C +L MD G SDP+V++ L + K KT+
Sbjct: 363 DLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTTTK 422
Query: 367 RKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWL 426
+ TLNP +NE + P E + Q +L ++V DYD ++ IG + G A G HW
Sbjct: 423 KNTLNPVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWN 482
Query: 427 ECLGHSDHRLELWHPLDSKP 446
E L + + WHPL P
Sbjct: 483 EMLAYHRKPITHWHPLLELP 502
Score = 75.9 bits (185), Expect = 7e-14
Identities = 41/106 (38%), Positives = 64/106 (60%), Gaps = 2/106 (1%)
Query: 308 CGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHR 367
CG + +L Y + L+V +++ L D G SDP+V+++L P+ +K KF+T VHR
Sbjct: 232 CGKLNFTLQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKMYLLPD--RKKKFQTRVHR 289
Query: 368 KTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
KTLNP F+E F + ++L+ + L SV+D+D + D IG V L
Sbjct: 290 KTLNPLFDETFQFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVIL 335
Score = 42.0 bits (97), Expect = 0.001
Identities = 32/97 (32%), Positives = 49/97 (50%), Gaps = 6/97 (6%)
Query: 64 RSAPQL--QPDPEPEGDSDDSTAL-GTLEFTLLFEADNSALHCTAHRAKGLKPLA-SGSA 119
R P+L Q + EG+ ++ + G L FTL ++ +N L +A L +G++
Sbjct: 208 RIKPELYKQKSVDSEGNQNEDVKICGKLNFTLQYDYENELLVVKIIKALDLPAKDFTGTS 267
Query: 120 DAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTY 156
D YVK LLP K Q R H R T P+++ET +
Sbjct: 268 DPYVKMYLLPDRKKKFQTRVH--RKTLNPLFDETFQF 302
Score = 37.4 bits (85), Expect = 0.028
Identities = 21/77 (27%), Positives = 40/77 (51%), Gaps = 1/77 (1%)
Query: 81 DSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQLRT 139
+S LG + F+L + + T + + LK + +GS+D YVK +L+ + + +T
Sbjct: 360 ESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKT 419
Query: 140 HTVRGTRVPVWEETLTY 156
T + T PV+ E + +
Sbjct: 420 TTKKNTLNPVYNEAIIF 436
>gi|92859638 synaptotagmin V [Homo sapiens]
Length = 386
Score = 91.3 bits (225), Expect = 2e-18
Identities = 50/123 (40%), Positives = 76/123 (61%), Gaps = 4/123 (3%)
Query: 307 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVH 366
E G + SL Y Q G LLVG+L+ LA +D G SDP+VR++L P+ K+ +++T VH
Sbjct: 108 ELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPD--KRRRYETKVH 165
Query: 367 RKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQ--LGSHASGERLRH 424
R+TLNP F E F + P EL + L+++V+D+D + +D IG V+ + S G ++
Sbjct: 166 RQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQA 225
Query: 425 WLE 427
W E
Sbjct: 226 WRE 228
Score = 90.9 bits (224), Expect = 2e-18
Identities = 49/137 (35%), Positives = 74/137 (54%)
Query: 306 EECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSV 365
E+ G + SL Y G L V VL +L MD G SDP+V++ L K K KT++
Sbjct: 238 EKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTI 297
Query: 366 HRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHW 425
+ TLNP +NE F + P +++ + + ++V DYD ++ IG V +G+ A G LRHW
Sbjct: 298 KKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRHW 357
Query: 426 LECLGHSDHRLELWHPL 442
+ L + + WH L
Sbjct: 358 ADMLANPRRPIAQWHSL 374
Score = 40.0 bits (92), Expect = 0.004
Identities = 39/137 (28%), Positives = 61/137 (44%), Gaps = 15/137 (10%)
Query: 68 QLQPDPEPEGDS-DDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKA 125
+L+P P G D LG L+++L ++ + L +A GL L GS+D YV+
Sbjct: 91 ELEPAPSGPGQQVADKHELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRV 150
Query: 126 NLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPM 185
LLP + + + H R T P + ET + K +LGG V
Sbjct: 151 YLLPDKRRRYETKVH--RQTLNPHFGETFAF----------KVPYVELGGRVLVMAVYDF 198
Query: 186 VQRQWQAPSLGELRVPL 202
R + ++GE+RVP+
Sbjct: 199 -DRFSRNDAIGEVRVPM 214
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 91.3 bits (225), Expect = 2e-18
Identities = 93/317 (29%), Positives = 144/317 (45%), Gaps = 52/317 (16%)
Query: 113 PLASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEET-LTYHGFTRQDAECKTLRS 171
P SG AY+ A +LPG S ++ + G +V W LT ++ E +++ S
Sbjct: 4524 PGHSGEIGAYI-AKILPGGS--AEQTGKLMEGMQVLEWNGIPLT----SKTYEEVQSIIS 4576
Query: 172 DLGGHQAVCVRGP--MVQRQWQAPSLGELRVPLRKLVPNRARSFD-----ICLEKRRLAK 224
G +CVR M+ + L EL P + + ++ D L+K L +
Sbjct: 4577 QQSGEAEICVRLDLNMLSDSENSQHL-ELHEPPKAVDKAKSPGVDPKQLAAELQKVSLQQ 4635
Query: 225 RPKSLDTACGMSLYEVVPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPS 284
P L + V G+ G TS S + P QP PS
Sbjct: 4636 SPLVLSSV-------VEKGSHVHSGPTSAGSSSVPSPG----------------QPGSPS 4672
Query: 285 APDPKHNSARSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSD 344
KH S++ + + V+ G + L + Y G L++ +L+ +L P D NGYSD
Sbjct: 4673 VSKKKHGSSKPTDGTKV-VSHPITGEIQLQINYDL--GNLIIHILQARNLVPRDNNGYSD 4729
Query: 345 PFVRLFLHP---------NAGKKSKFKTSVHRKTLNPEFNEEFFY-SGPREELAQKTLLV 394
PFV+++L P NA + K +T +K+LNPE+N+ Y S E+L +KTL V
Sbjct: 4730 PFVKVYLLPGRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEV 4789
Query: 395 SVWDYDLGTADDFIGGV 411
+VWDYD +++DF+G V
Sbjct: 4790 TVWDYDRFSSNDFLGEV 4806
Score = 35.8 bits (81), Expect = 0.082
Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 12/94 (12%)
Query: 86 GTLEFTLLFEADNSALHCTAHRAKGLKPLAS-GSADAYVKANLLPG---------ASKAS 135
G ++ + ++ N +H +A+ L P + G +D +VK LLPG AS
Sbjct: 4696 GEIQLQINYDLGNLIIHIL--QARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEY 4753
Query: 136 QLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTL 169
+ RT V+ + P W +T+ Y + + + KTL
Sbjct: 4754 KRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTL 4787
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 91.3 bits (225), Expect = 2e-18
Identities = 93/317 (29%), Positives = 144/317 (45%), Gaps = 52/317 (16%)
Query: 113 PLASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEET-LTYHGFTRQDAECKTLRS 171
P SG AY+ A +LPG S ++ + G +V W LT ++ E +++ S
Sbjct: 4524 PGHSGEIGAYI-AKILPGGS--AEQTGKLMEGMQVLEWNGIPLT----SKTYEEVQSIIS 4576
Query: 172 DLGGHQAVCVRGP--MVQRQWQAPSLGELRVPLRKLVPNRARSFD-----ICLEKRRLAK 224
G +CVR M+ + L EL P + + ++ D L+K L +
Sbjct: 4577 QQSGEAEICVRLDLNMLSDSENSQHL-ELHEPPKAVDKAKSPGVDPKQLAAELQKVSLQQ 4635
Query: 225 RPKSLDTACGMSLYEVVPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPS 284
P L + V G+ G TS S + P QP PS
Sbjct: 4636 SPLVLSSV-------VEKGSHVHSGPTSAGSSSVPSPG----------------QPGSPS 4672
Query: 285 APDPKHNSARSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSD 344
KH S++ + + V+ G + L + Y G L++ +L+ +L P D NGYSD
Sbjct: 4673 VSKKKHGSSKPTDGTKV-VSHPITGEIQLQINYDL--GNLIIHILQARNLVPRDNNGYSD 4729
Query: 345 PFVRLFLHP---------NAGKKSKFKTSVHRKTLNPEFNEEFFY-SGPREELAQKTLLV 394
PFV+++L P NA + K +T +K+LNPE+N+ Y S E+L +KTL V
Sbjct: 4730 PFVKVYLLPGRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEV 4789
Query: 395 SVWDYDLGTADDFIGGV 411
+VWDYD +++DF+G V
Sbjct: 4790 TVWDYDRFSSNDFLGEV 4806
Score = 35.8 bits (81), Expect = 0.082
Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 12/94 (12%)
Query: 86 GTLEFTLLFEADNSALHCTAHRAKGLKPLAS-GSADAYVKANLLPG---------ASKAS 135
G ++ + ++ N +H +A+ L P + G +D +VK LLPG AS
Sbjct: 4696 GEIQLQINYDLGNLIIHIL--QARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEY 4753
Query: 136 QLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTL 169
+ RT V+ + P W +T+ Y + + + KTL
Sbjct: 4754 KRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTL 4787
>gi|38570146 synaptotagmin VII [Homo sapiens]
Length = 403
Score = 91.3 bits (225), Expect = 2e-18
Identities = 43/134 (32%), Positives = 74/134 (55%)
Query: 309 GHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRK 368
G +LLSLCY+ ++V +++ +L MD G SDP+V+++L + K KT ++
Sbjct: 268 GELLLSLCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKR 327
Query: 369 TLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLEC 428
LNP FNE F + P E+L + T++++V D D + +D IG + L + ++HW +
Sbjct: 328 NLNPIFNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKSGPGEVKHWKDM 387
Query: 429 LGHSDHRLELWHPL 442
+ + WH L
Sbjct: 388 IARPRQPVAQWHQL 401
Score = 79.7 bits (195), Expect = 5e-15
Identities = 44/118 (37%), Positives = 68/118 (57%), Gaps = 3/118 (2%)
Query: 297 EEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAG 356
+E + E G + S+ Y+ Q+ L V +++ L D +G SDPFV+++L P+
Sbjct: 125 DEAHEGCSRENLGRIQFSVGYNFQESTLTVKIMKAQELPAKDFSGTSDPFVKIYLLPD-- 182
Query: 357 KKSKFKTSVHRKTLNPEFNEEFFYSG-PREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
KK K +T V RK LNP +NE F + G P E++ Q+ L + V DYD + +D IG V +
Sbjct: 183 KKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSI 240
Score = 42.4 bits (98), Expect = 9e-04
Identities = 38/149 (25%), Positives = 65/149 (43%), Gaps = 15/149 (10%)
Query: 66 APQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLA-SGSADAYVK 124
+P + D EG S ++ LG ++F++ + S L +A+ L SG++D +VK
Sbjct: 119 SPGSEEDEAHEGCSREN--LGRIQFSVGYNFQESTLTVKIMKAQELPAKDFSGTSDPFVK 176
Query: 125 ANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGP 184
LLP K +L T R P W ET + GF + + L + + P
Sbjct: 177 IYLLP--DKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDP 234
Query: 185 MVQRQWQAPSLGELRVPLRKLVPNRARSF 213
+GE+ +PL K+ + ++F
Sbjct: 235 ----------IGEVSIPLNKVDLTQMQTF 253
Score = 32.0 bits (71), Expect = 1.2
Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 79 SDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQL 137
SD S + G L +L + +++ +A+ LK + G++D YVK L+ + +
Sbjct: 261 SDGSGSRGELLLSLCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKK 320
Query: 138 RTHTVRGTRVPVWEETLTY 156
+T T++ P++ E+ +
Sbjct: 321 KTVTMKRNLNPIFNESFAF 339
>gi|28376627 synaptotagmin IX [Homo sapiens]
Length = 491
Score = 90.1 bits (222), Expect = 4e-18
Identities = 48/139 (34%), Positives = 72/139 (51%)
Query: 307 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVH 366
+ G ++ SLCY G L + +++ +L MD G SDP+V++ L + + K KTS
Sbjct: 352 DLGELMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTK 411
Query: 367 RKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWL 426
R TLNP +NE + P E + Q L ++V DYD ++ IG Q+G+ A HW
Sbjct: 412 RNTLNPVYNEAIVFDVPPENIDQIHLSIAVMDYDRVGHNEIIGVCQVGNEAERLGRDHWS 471
Query: 427 ECLGHSDHRLELWHPLDSK 445
E L + + WH L K
Sbjct: 472 EMLSYPRKPIAHWHSLVEK 490
Score = 74.3 bits (181), Expect = 2e-13
Identities = 40/104 (38%), Positives = 61/104 (58%), Gaps = 2/104 (1%)
Query: 308 CGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHR 367
CG + L Y L+V + + +L D +G SDP+V+++L P+ +K+K +T VHR
Sbjct: 221 CGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPD--RKTKHQTKVHR 278
Query: 368 KTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGV 411
KTLNP F+E F + P +L + L SV+D+D + D IG V
Sbjct: 279 KTLNPVFDEVFLFPVPYNDLEARKLHFSVYDFDRFSRHDLIGQV 322
Score = 42.7 bits (99), Expect = 7e-04
Identities = 24/79 (30%), Positives = 43/79 (54%), Gaps = 1/79 (1%)
Query: 79 SDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQL 137
++D+ LG L F+L + L T +A+ LK + +G++D YVK +L+ + +
Sbjct: 347 TNDNVDLGELMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKR 406
Query: 138 RTHTVRGTRVPVWEETLTY 156
+T T R T PV+ E + +
Sbjct: 407 KTSTKRNTLNPVYNEAIVF 425
Score = 41.6 bits (96), Expect = 0.001
Identities = 28/82 (34%), Positives = 39/82 (47%), Gaps = 3/82 (3%)
Query: 76 EGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLA-SGSADAYVKANLLPGASKA 134
+G +S A G L F L ++ D L H+A L SG++D YVK LLP
Sbjct: 212 DGRRSNSKACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTK 271
Query: 135 SQLRTHTVRGTRVPVWEETLTY 156
Q + H R T PV++E +
Sbjct: 272 HQTKVH--RKTLNPVFDEVFLF 291
>gi|40068038 B/K protein [Homo sapiens]
Length = 474
Score = 87.0 bits (214), Expect = 3e-17
Identities = 50/140 (35%), Positives = 76/140 (54%), Gaps = 1/140 (0%)
Query: 307 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVH 366
E G +LLSL Y G L V V+R L D + SDPFV++ L KTS
Sbjct: 321 ELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFL 380
Query: 367 RKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASG-ERLRHW 425
R T++P +NE F + P+EEL +L+ +V+ +++ +++DFIG + +G ++SG HW
Sbjct: 381 RGTIDPFYNESFSFKVPQEELENASLVFTVFGHNMKSSNDFIGRIVIGQYSSGPSETNHW 440
Query: 426 LECLGHSDHRLELWHPLDSK 445
L +E WH L S+
Sbjct: 441 RRMLNTHRTAVEQWHSLRSR 460
Score = 44.7 bits (104), Expect = 2e-04
Identities = 33/114 (28%), Positives = 56/114 (49%), Gaps = 9/114 (7%)
Query: 307 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDAN-------GYSDPFVRLFLHPNAGKKS 359
+ G + S Y L V V+ L P ++ +S+P+V++ L P+ +K+
Sbjct: 184 QLGMLHFSTQYDLLHNHLTVRVIEARDLPPPISHDGSRQDMAHSNPYVKICLLPD--QKN 241
Query: 360 KFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
+T V RKT P F E + + P E ++TLL++V D+D + IG V +
Sbjct: 242 SKQTGVKRKTQKPVFEERYTFEIPFLEAQRRTLLLTVVDFDKFSRHCVIGKVSV 295
Score = 30.8 bits (68), Expect = 2.6
Identities = 26/99 (26%), Positives = 44/99 (44%), Gaps = 2/99 (2%)
Query: 79 SDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQL 137
S + LG L +L + L+ RAK L S +D +VK L+ G
Sbjct: 316 SQNEVELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTK 375
Query: 138 RTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGH 176
+T +RGT P + E+ ++ +++ E +L + GH
Sbjct: 376 KTSFLRGTIDPFYNESFSFK-VPQEELENASLVFTVFGH 413
>gi|24308219 synaptotagmin IV [Homo sapiens]
Length = 425
Score = 84.7 bits (208), Expect = 2e-16
Identities = 49/134 (36%), Positives = 71/134 (52%)
Query: 309 GHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRK 368
G +L+SLCY S L V VL+ HL D +G SDP+V++ L+ + SK KT V +
Sbjct: 289 GELLISLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTHVKKC 348
Query: 369 TLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLEC 428
T N FNE F + P E L ++ V D + G+ ++ IG + LG+ A G HW E
Sbjct: 349 TPNAVFNELFVFDIPCEGLEDISVEFLVLDSERGSRNEVIGQLVLGAAAEGTGGEHWKEI 408
Query: 429 LGHSDHRLELWHPL 442
+ ++ WH L
Sbjct: 409 CDYPRRQIAKWHVL 422
Score = 62.0 bits (149), Expect = 1e-09
Identities = 40/122 (32%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 292 SARSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGY-SDPFVRLF 350
S +S + +E E+ G + SL Y+ ++ +V + L MD SDP++++
Sbjct: 138 SLKSSTSLTSEEKQEKLGTLFFSLEYNFERKAFVVNIKEARGLPAMDEQSMTSDPYIKMT 197
Query: 351 LHPNAGKKSKFKTSVHRKTLNPEFNEEF-FYSGPREELAQKTLLVSVWDYDLGTADDFIG 409
+ P KK K KT V RKTL+P F+E F FY P ++ + L ++ +D + DD IG
Sbjct: 198 ILPE--KKHKVKTRVLRKTLDPAFDETFTFYGIPYTQIQELALHFTILSFDRFSRDDIIG 255
Query: 410 GV 411
V
Sbjct: 256 EV 257
Score = 47.4 bits (111), Expect = 3e-05
Identities = 36/121 (29%), Positives = 60/121 (49%), Gaps = 18/121 (14%)
Query: 54 NLRPAAASAVRSA-PQLQPDPEPEGDSDDSTA-------------LGTLEFTLLFEADNS 99
NL+P + S + +A P+L + E E S +S LGTL F+L + +
Sbjct: 109 NLKPGSPSDLENATPKLFLEGEKESVSPESLKSSTSLTSEEKQEKLGTLFFSLEYNFERK 168
Query: 100 ALHCTAHRAKGLKPL--ASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYH 157
A A+GL + S ++D Y+K +LP K +++T +R T P ++ET T++
Sbjct: 169 AFVVNIKEARGLPAMDEQSMTSDPYIKMTILP--EKKHKVKTRVLRKTLDPAFDETFTFY 226
Query: 158 G 158
G
Sbjct: 227 G 227
Score = 35.0 bits (79), Expect = 0.14
Identities = 28/103 (27%), Positives = 44/103 (42%), Gaps = 5/103 (4%)
Query: 82 STALGTLEFTLLFEADNSALHCTAHRAKGL-KPLASGSADAYVKANLLPGASKASQLRTH 140
S+ G L +L +++ + L +A+ L K SG +D YVK NL + S+ +TH
Sbjct: 285 SSGRGELLISLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTH 344
Query: 141 TVRGTRVPVWEETLTY----HGFTRQDAECKTLRSDLGGHQAV 179
+ T V+ E + G E L S+ G V
Sbjct: 345 VKKCTPNAVFNELFVFDIPCEGLEDISVEFLVLDSERGSRNEV 387
>gi|94536846 synaptotagmin VIII [Homo sapiens]
Length = 401
Score = 82.4 bits (202), Expect = 8e-16
Identities = 48/137 (35%), Positives = 71/137 (51%), Gaps = 4/137 (2%)
Query: 306 EECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSV 365
E+ G + SL Y G L V VL L P G ++P+V++ L N K K KT+
Sbjct: 244 EQVGELCFSLRYVPSSGRLTVVVLEARGLRP----GLAEPYVKVQLMLNQRKWKKRKTAT 299
Query: 366 HRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHW 425
+ T P FNE F + P ++ L+++VWD L + +G V LG+ ASG+ L+HW
Sbjct: 300 KKGTAAPYFNEAFTFLVPFSQVQNVDLVLAVWDRSLPLRTEPVGKVHLGARASGQPLQHW 359
Query: 426 LECLGHSDHRLELWHPL 442
+ L H+ + HPL
Sbjct: 360 ADMLAHARRPIAQRHPL 376
Score = 47.8 bits (112), Expect = 2e-05
Identities = 36/122 (29%), Positives = 61/122 (50%), Gaps = 7/122 (5%)
Query: 306 EECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSV 365
++ G + LSL + + VG+ + A L P G DP+ R+ + AG + + T V
Sbjct: 116 QQWGRLQLSLEFDFGSQEIRVGLRQAADLRP---GGTVDPYARVSVSTQAGHRHE--TKV 170
Query: 366 HRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQ--LGSHASGERLR 423
HR TL P F+E + P+ EL TL V ++++ + + +G ++ LG+ L
Sbjct: 171 HRGTLCPVFDETCCFHIPQAELPGATLQVQLFNFKRFSGHEPLGELRLPLGTVDLQHVLE 230
Query: 424 HW 425
HW
Sbjct: 231 HW 232
Score = 42.7 bits (99), Expect = 7e-04
Identities = 36/135 (26%), Positives = 60/135 (44%), Gaps = 16/135 (11%)
Query: 69 LQPDPEP-EGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSADAYVKANL 127
+QPD + E D+ G L+ +L F+ + + +A L+P G+ D Y + ++
Sbjct: 101 VQPDVDGLESSPGDAQQWGRLQLSLEFDFGSQEIRVGLRQAADLRP--GGTVDPYARVSV 158
Query: 128 LPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQ 187
A + + H RGT PV++ET +H + + TL+ L + P
Sbjct: 159 STQAGHRHETKVH--RGTLCPVFDETCCFH-IPQAELPGATLQVQLFNFKRFSGHEP--- 212
Query: 188 RQWQAPSLGELRVPL 202
LGELR+PL
Sbjct: 213 -------LGELRLPL 220
Score = 39.7 bits (91), Expect = 0.006
Identities = 23/72 (31%), Positives = 36/72 (50%), Gaps = 3/72 (4%)
Query: 85 LGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSADAYVKANLLPGASKASQLRTHTVRG 144
+G L F+L + + L A+GL+P G A+ YVK L+ K + +T T +G
Sbjct: 246 VGELCFSLRYVPSSGRLTVVVLEARGLRP---GLAEPYVKVQLMLNQRKWKKRKTATKKG 302
Query: 145 TRVPVWEETLTY 156
T P + E T+
Sbjct: 303 TAAPYFNEAFTF 314
>gi|45387945 family with sequence similarity 62 (C2 domain
containing) member B [Homo sapiens]
Length = 893
Score = 78.2 bits (191), Expect = 1e-14
Identities = 84/316 (26%), Positives = 128/316 (40%), Gaps = 84/316 (26%)
Query: 145 TRVPVWEETLTY--HGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSLGELRVPL 202
T PVWEE T+ H RQD E + V+ + SLG L+VPL
Sbjct: 551 TNEPVWEENFTFFIHNPKRQDLEVE------------------VRDEQHQCSLGNLKVPL 592
Query: 203 RKLV-----------------PNRARSFDICL-----EKRRL---------AKRPKSLDT 231
+L+ PN I L EKR KRP
Sbjct: 593 SQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKE 652
Query: 232 ACGMSLYEVVPGAPPPGGATSCCSCRL------------AKPKWLKP-----------TK 268
S+ + G+P PGG+ + S + A+P P +
Sbjct: 653 GRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSL 712
Query: 269 VAWTGHFTQRQPR--------VPSAPDPKHNSARSMEEVETEVAWEECGHVLLSLCYSSQ 320
+A GH + ++P +P A R +E T + G + L++ +SSQ
Sbjct: 713 LASPGHISVKEPTPSIASDISLPIATQELRQRLRQLEN-GTTLGQSPLGQIQLTIRHSSQ 771
Query: 321 QGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFY 380
+ L+V V C +L +G SDP+VR++L P+ + + KT V +KTLNP F++ F +
Sbjct: 772 RNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDF 830
Query: 381 SGPREELAQKTLLVSV 396
S E+ ++TL V+V
Sbjct: 831 SVSLPEVQRRTLDVAV 846
Score = 39.3 bits (90), Expect = 0.007
Identities = 18/80 (22%), Positives = 39/80 (48%)
Query: 77 GDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSADAYVKANLLPGASKASQ 136
G + + LG ++ T+ + + L H + L + +D YV+ LLP ++ +
Sbjct: 751 GTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGR 810
Query: 137 LRTHTVRGTRVPVWEETLTY 156
+TH + T PV++++ +
Sbjct: 811 RKTHVSKKTLNPVFDQSFDF 830
>gi|193804862 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 77.0 bits (188), Expect = 3e-14
Identities = 47/128 (36%), Positives = 68/128 (53%), Gaps = 6/128 (4%)
Query: 322 GGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYS 381
G L V + +L A G SD FV+ +L P K SK KT V +KTLNP +N F Y+
Sbjct: 526 GELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYN 585
Query: 382 GPR-EELAQKTLLVSVWDYDLGTADDFIGGVQL--GSHASGERLRHWLECLGHSDHRLEL 438
G R E+L L ++VWD + ++DF+GGV+L G+ S + W++ G + L
Sbjct: 586 GVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTG---EEVSL 642
Query: 439 WHPLDSKP 446
W + P
Sbjct: 643 WQKMRQYP 650
Score = 72.0 bits (175), Expect = 1e-12
Identities = 45/125 (36%), Positives = 66/125 (52%), Gaps = 3/125 (2%)
Query: 309 GHVLLSLCYSSQQGGLLVGVLRCAHLAPMD-ANGYSDPFVRLFLHPNAGKKSKFKTSVHR 367
G + SL Y Q L+V V C LA D A S+P+V+ +L P+ ++ K KTS+ R
Sbjct: 358 GRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKR 417
Query: 368 KTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIG--GVQLGSHASGERLRHW 425
T+NP ++E Y P LAQ+TL SVW + + F+G +Q+ S ++L H
Sbjct: 418 DTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHC 477
Query: 426 LECLG 430
L G
Sbjct: 478 LPLHG 482
Score = 38.9 bits (89), Expect = 0.010
Identities = 18/51 (35%), Positives = 31/51 (60%)
Query: 115 ASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAE 165
A G++D++VK LLP +KAS+ +T ++ T P + T Y+G +D +
Sbjct: 543 AGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQ 593
Score = 36.6 bits (83), Expect = 0.048
Identities = 24/82 (29%), Positives = 37/82 (45%), Gaps = 2/82 (2%)
Query: 77 GDSDDSTALGTLEFTLLFEADNSAL--HCTAHRAKGLKPLASGSADAYVKANLLPGASKA 134
GD + G + F+L +E +L H A ++ YVK LLP S+
Sbjct: 349 GDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQ 408
Query: 135 SQLRTHTVRGTRVPVWEETLTY 156
+ +T R T P+++ETL Y
Sbjct: 409 GKRKTSIKRDTINPLYDETLRY 430
>gi|193804860 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 77.0 bits (188), Expect = 3e-14
Identities = 47/128 (36%), Positives = 68/128 (53%), Gaps = 6/128 (4%)
Query: 322 GGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYS 381
G L V + +L A G SD FV+ +L P K SK KT V +KTLNP +N F Y+
Sbjct: 526 GELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYN 585
Query: 382 GPR-EELAQKTLLVSVWDYDLGTADDFIGGVQL--GSHASGERLRHWLECLGHSDHRLEL 438
G R E+L L ++VWD + ++DF+GGV+L G+ S + W++ G + L
Sbjct: 586 GVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTG---EEVSL 642
Query: 439 WHPLDSKP 446
W + P
Sbjct: 643 WQKMRQYP 650
Score = 72.0 bits (175), Expect = 1e-12
Identities = 45/125 (36%), Positives = 66/125 (52%), Gaps = 3/125 (2%)
Query: 309 GHVLLSLCYSSQQGGLLVGVLRCAHLAPMD-ANGYSDPFVRLFLHPNAGKKSKFKTSVHR 367
G + SL Y Q L+V V C LA D A S+P+V+ +L P+ ++ K KTS+ R
Sbjct: 358 GRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKR 417
Query: 368 KTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIG--GVQLGSHASGERLRHW 425
T+NP ++E Y P LAQ+TL SVW + + F+G +Q+ S ++L H
Sbjct: 418 DTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHC 477
Query: 426 LECLG 430
L G
Sbjct: 478 LPLHG 482
Score = 38.9 bits (89), Expect = 0.010
Identities = 18/51 (35%), Positives = 31/51 (60%)
Query: 115 ASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAE 165
A G++D++VK LLP +KAS+ +T ++ T P + T Y+G +D +
Sbjct: 543 AGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQ 593
Score = 36.6 bits (83), Expect = 0.048
Identities = 24/82 (29%), Positives = 37/82 (45%), Gaps = 2/82 (2%)
Query: 77 GDSDDSTALGTLEFTLLFEADNSAL--HCTAHRAKGLKPLASGSADAYVKANLLPGASKA 134
GD + G + F+L +E +L H A ++ YVK LLP S+
Sbjct: 349 GDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQ 408
Query: 135 SQLRTHTVRGTRVPVWEETLTY 156
+ +T R T P+++ETL Y
Sbjct: 409 GKRKTSIKRDTINPLYDETLRY 430
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 72.8 bits (177), Expect = 6e-13
Identities = 49/134 (36%), Positives = 67/134 (50%), Gaps = 19/134 (14%)
Query: 282 VPSAPDPKHNSARSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANG 341
VPS H R ++ EVA E+ L V V +L PMD NG
Sbjct: 147 VPSLCGMDHTEKRGRIYLKAEVADEK----------------LHVTVRDAKNLIPMDPNG 190
Query: 342 YSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEF-FYSGPREELAQKTLLVSVWDYD 400
SDP+V+L L P+ +SK KT R TLNP++NE F F P ++ + L V +WD+D
Sbjct: 191 LSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDK--DRRLSVEIWDWD 248
Query: 401 LGTADDFIGGVQLG 414
T +DF+G + G
Sbjct: 249 RTTRNDFMGSLSFG 262
Score = 47.4 bits (111), Expect = 3e-05
Identities = 24/63 (38%), Positives = 34/63 (53%), Gaps = 1/63 (1%)
Query: 95 EADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEET 153
E + LH T AK L P+ +G +D YVK L+P S+ +T T+R T P W E+
Sbjct: 167 EVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNES 226
Query: 154 LTY 156
T+
Sbjct: 227 FTF 229
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 72.4 bits (176), Expect = 8e-13
Identities = 41/111 (36%), Positives = 62/111 (55%), Gaps = 2/111 (1%)
Query: 324 LLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGP 383
L+V V +L PMD NG SDP+V+L L P+ +SK KT + +LNPE+NE F +
Sbjct: 173 LIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQ-L 231
Query: 384 REELAQKTLLVSVWDYDLGTADDFIGGVQLG-SHASGERLRHWLECLGHSD 433
+E + L V +WD+DL + +DF+G + G S + W + L +
Sbjct: 232 KESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEE 282
Score = 37.7 bits (86), Expect = 0.021
Identities = 20/61 (32%), Positives = 30/61 (49%), Gaps = 1/61 (1%)
Query: 97 DNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLT 155
D L AK L P+ +G +D YVK L+P S+ +T T++ + P W ET
Sbjct: 169 DRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFR 228
Query: 156 Y 156
+
Sbjct: 229 F 229
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,262,932
Number of Sequences: 37866
Number of extensions: 1079097
Number of successful extensions: 4025
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 88
Number of HSP's successfully gapped in prelim test: 91
Number of HSP's that attempted gapping in prelim test: 3540
Number of HSP's gapped (non-prelim): 464
length of query: 451
length of database: 18,247,518
effective HSP length: 106
effective length of query: 345
effective length of database: 14,233,722
effective search space: 4910634090
effective search space used: 4910634090
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.