Guide to the Human Genome
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Search of human proteins with 169202933

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|169202933 PREDICTED: similar to hCG21066 [Homo sapiens]
         (451 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|169202933 PREDICTED: similar to hCG21066 [Homo sapiens]            939   0.0  
gi|169203543 PREDICTED: similar to hCG21066 [Homo sapiens]            939   0.0  
gi|239744413 PREDICTED: hypothetical protein LOC390213 [Homo sap...   455   e-128
gi|47078261 double C2-like domains, alpha [Homo sapiens]              317   1e-86
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]            197   2e-50
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]             197   2e-50
gi|6005997 double C2-like domains, beta [Homo sapiens]                191   2e-48
gi|211059429 synaptotagmin II [Homo sapiens]                          102   7e-22
gi|31543670 synaptotagmin II [Homo sapiens]                           102   7e-22
gi|209447073 synaptotagmin I [Homo sapiens]                           100   4e-21
gi|5032139 synaptotagmin I [Homo sapiens]                             100   4e-21
gi|209447070 synaptotagmin I [Homo sapiens]                           100   4e-21
gi|45504376 synaptotagmin VI [Homo sapiens]                            99   6e-21
gi|238550198 synaptotagmin III [Homo sapiens]                          93   4e-19
gi|238550196 synaptotagmin III [Homo sapiens]                          93   4e-19
gi|14150054 synaptotagmin III [Homo sapiens]                           93   4e-19
gi|39752671 synaptotagmin X [Homo sapiens]                             93   6e-19
gi|92859638 synaptotagmin V [Homo sapiens]                             91   2e-18
gi|150170670 piccolo isoform 2 [Homo sapiens]                          91   2e-18
gi|150378539 piccolo isoform 1 [Homo sapiens]                          91   2e-18
gi|38570146 synaptotagmin VII [Homo sapiens]                           91   2e-18
gi|28376627 synaptotagmin IX [Homo sapiens]                            90   4e-18
gi|40068038 B/K protein [Homo sapiens]                                 87   3e-17
gi|24308219 synaptotagmin IV [Homo sapiens]                            85   2e-16
gi|94536846 synaptotagmin VIII [Homo sapiens]                          82   8e-16
gi|45387945 family with sequence similarity 62 (C2 domain contai...    78   1e-14
gi|193804862 synaptotagmin-like 4 [Homo sapiens]                       77   3e-14
gi|193804860 synaptotagmin-like 4 [Homo sapiens]                       77   3e-14
gi|4506067 protein kinase C, alpha [Homo sapiens]                      73   6e-13
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]            72   8e-13

>gi|169202933 PREDICTED: similar to hCG21066 [Homo sapiens]
          Length = 451

 Score =  939 bits (2427), Expect = 0.0
 Identities = 451/451 (100%), Positives = 451/451 (100%)

Query: 1   MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA 60
           MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA
Sbjct: 1   MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA 60

Query: 61  SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD 120
           SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD
Sbjct: 61  SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD 120

Query: 121 AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC 180
           AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC
Sbjct: 121 AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC 180

Query: 181 VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLAKRPKSLDTACGMSLYEV 240
           VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLAKRPKSLDTACGMSLYEV
Sbjct: 181 VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLAKRPKSLDTACGMSLYEV 240

Query: 241 VPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPSAPDPKHNSARSMEEVE 300
           VPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPSAPDPKHNSARSMEEVE
Sbjct: 241 VPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPSAPDPKHNSARSMEEVE 300

Query: 301 TEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSK 360
           TEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSK
Sbjct: 301 TEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSK 360

Query: 361 FKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGE 420
           FKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGE
Sbjct: 361 FKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGE 420

Query: 421 RLRHWLECLGHSDHRLELWHPLDSKPVQLSD 451
           RLRHWLECLGHSDHRLELWHPLDSKPVQLSD
Sbjct: 421 RLRHWLECLGHSDHRLELWHPLDSKPVQLSD 451


>gi|169203543 PREDICTED: similar to hCG21066 [Homo sapiens]
          Length = 451

 Score =  939 bits (2427), Expect = 0.0
 Identities = 451/451 (100%), Positives = 451/451 (100%)

Query: 1   MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA 60
           MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA
Sbjct: 1   MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA 60

Query: 61  SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD 120
           SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD
Sbjct: 61  SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD 120

Query: 121 AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC 180
           AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC
Sbjct: 121 AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC 180

Query: 181 VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLAKRPKSLDTACGMSLYEV 240
           VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLAKRPKSLDTACGMSLYEV
Sbjct: 181 VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLAKRPKSLDTACGMSLYEV 240

Query: 241 VPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPSAPDPKHNSARSMEEVE 300
           VPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPSAPDPKHNSARSMEEVE
Sbjct: 241 VPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPSAPDPKHNSARSMEEVE 300

Query: 301 TEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSK 360
           TEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSK
Sbjct: 301 TEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSK 360

Query: 361 FKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGE 420
           FKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGE
Sbjct: 361 FKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGE 420

Query: 421 RLRHWLECLGHSDHRLELWHPLDSKPVQLSD 451
           RLRHWLECLGHSDHRLELWHPLDSKPVQLSD
Sbjct: 421 RLRHWLECLGHSDHRLELWHPLDSKPVQLSD 451


>gi|239744413 PREDICTED: hypothetical protein LOC390213 [Homo
           sapiens]
          Length = 431

 Score =  455 bits (1171), Expect = e-128
 Identities = 222/222 (100%), Positives = 222/222 (100%)

Query: 1   MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA 60
           MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA
Sbjct: 55  MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA 114

Query: 61  SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD 120
           SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD
Sbjct: 115 SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD 174

Query: 121 AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC 180
           AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC
Sbjct: 175 AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC 234

Query: 181 VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRL 222
           VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRL
Sbjct: 235 VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRL 276



 Score =  329 bits (844), Expect = 3e-90
 Identities = 155/158 (98%), Positives = 157/158 (99%)

Query: 294 RSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP 353
           R +EEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP
Sbjct: 274 RRLEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP 333

Query: 354 NAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
           NAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL
Sbjct: 334 NAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 393

Query: 414 GSHASGERLRHWLECLGHSDHRLELWHPLDSKPVQLSD 451
           GSHASGERLRHWLECLGHSDHRL+LWHPLDSKPVQLSD
Sbjct: 394 GSHASGERLRHWLECLGHSDHRLKLWHPLDSKPVQLSD 431



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 31/114 (27%), Positives = 50/114 (43%), Gaps = 12/114 (10%)

Query: 280 PRVPSAPDPKHNSARSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDA 339
           P++   P+P+ +S  S             G +  +L + +    L     R   L P+ A
Sbjct: 121 PQLQPDPEPEGDSDDSTA----------LGTLEFTLLFEADNSALHCTAHRAKGLKPL-A 169

Query: 340 NGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSG-PREELAQKTL 392
           +G +D +V+  L P A K S+ +T   R T  P + E   Y G  R++   KTL
Sbjct: 170 SGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTL 223



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 26/85 (30%), Positives = 40/85 (47%), Gaps = 2/85 (2%)

Query: 86  GTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQLRTHTVRG 144
           G +  +L + +    L     R   L P+ A+G +D +V+  L P A K S+ +T   R 
Sbjct: 289 GHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRK 348

Query: 145 TRVPVWEETLTYHGFTRQDAECKTL 169
           T  P + E   Y G  R++   KTL
Sbjct: 349 TLNPEFNEEFFYSG-PREELAQKTL 372


>gi|47078261 double C2-like domains, alpha [Homo sapiens]
          Length = 400

 Score =  317 bits (813), Expect = 1e-86
 Identities = 199/449 (44%), Positives = 251/449 (55%), Gaps = 77/449 (17%)

Query: 9   GQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAE---------PA-LHPPNLRPA 58
           G    +++QEHMAI+V PGPIRPIR IS YFP   P  E         PA L P  L P 
Sbjct: 6   GDRMTINIQEHMAINVCPGPIRPIRQISDYFPRG-PGPEGGGGGGGEAPAHLVPLALAPP 64

Query: 59  AASAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLA-SG 117
           AA    + P+   + +   DSDD+TALGTLEF LL++  +  LHC+  RAKGLKP+  +G
Sbjct: 65  AALLGATTPEDGAEVDSY-DSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNG 123

Query: 118 SADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQ 177
            AD YVK +LLPGA KA++L+T T R T  PVW E LTY G T  D   K LR       
Sbjct: 124 LADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRI------ 177

Query: 178 AVCVRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLAKRPKSLDTACGMSL 237
           AVC    +   ++    +GE+RVPLR+L P++ + F+ICLE++     P S+        
Sbjct: 178 AVCDEDKLSHNEF----IGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSA------ 227

Query: 238 YEVVPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPSAPDPKHNSARSME 297
                       A    SC L                                   + +E
Sbjct: 228 ------------ALRGISCYL-----------------------------------KELE 240

Query: 298 EVET-EVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAG 356
           + E  +   EE G +LLSL YSS++ GLLVG+LRCAHLA MD NGYSDP+V+ +L P+  
Sbjct: 241 QAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVD 300

Query: 357 KKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSH 416
           KKSK KT V +KTLNPEFNEEFFY      LA KTL V+VWDYD+G ++DFIGGV LG  
Sbjct: 301 KKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPG 360

Query: 417 ASGERLRHWLECLGHSDHRLELWHPLDSK 445
           A GE  +HW +CL   D  LE WH L S+
Sbjct: 361 ARGEARKHWSDCLQQPDAALERWHTLTSE 389


>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
          Length = 694

 Score =  197 bits (500), Expect = 2e-50
 Identities = 95/165 (57%), Positives = 122/165 (73%), Gaps = 5/165 (3%)

Query: 292 SARSM-----EEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPF 346
           SAR M     E+VE     EE G +L+SL YS+QQGGL+VG++RC HLA MDANGYSDPF
Sbjct: 530 SARGMALYEEEQVERVGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPF 589

Query: 347 VRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADD 406
           V+L+L P+ GKK+K KT + +KTLNPEFNEEFFY     +LA+K+L +SVWDYD+G ++D
Sbjct: 590 VKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSND 649

Query: 407 FIGGVQLGSHASGERLRHWLECLGHSDHRLELWHPLDSKPVQLSD 451
           +IGG QLG  A GERL+HW ECL + D ++E WH L ++    SD
Sbjct: 650 YIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQNENHVSSD 694



 Score =  154 bits (390), Expect = 1e-37
 Identities = 91/198 (45%), Positives = 125/198 (63%), Gaps = 19/198 (9%)

Query: 51  HP--PNLRPAAASAVRSAPQLQPDPEPEG------DSDDSTALGTLEFTLLFEADNSALH 102
           HP  P  + +AA+   +A +  P PE E       DSD++T LG LEF+LL++ DNS+L 
Sbjct: 351 HPSGPYSQASAAAPQPAAARQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQ 410

Query: 103 CTAHRAKGLKPLAS-GSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTR 161
           CT  +AKGLKP+ S G AD YVK +LLPGASK+++LRT T+R TR P+W ETL YHG T 
Sbjct: 411 CTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITD 470

Query: 162 QDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRR 221
           +D + KTLR       +VC        ++    +GE R  L+KL PN+ ++F+ICLE+  
Sbjct: 471 EDMQRKTLRI------SVCDEDKFGHNEF----IGETRFSLKKLKPNQRKNFNICLERVI 520

Query: 222 LAKRPKSLDTACGMSLYE 239
             KR  +  +A GM+LYE
Sbjct: 521 PMKRAGTTGSARGMALYE 538



 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 46/130 (35%), Positives = 66/130 (50%), Gaps = 5/130 (3%)

Query: 281 RVPSAPDPKHNSARSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDAN 340
           R P  P+ +   A S +  E        G +  SL Y      L   +++   L PMD+N
Sbjct: 370 RQPPPPEEEEEEANSYDSDEATTL----GALEFSLLYDQDNSSLQCTIIKAKGLKPMDSN 425

Query: 341 GYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSG-PREELAQKTLLVSVWDY 399
           G +DP+V+L L P A K +K +T   R T NP +NE   Y G   E++ +KTL +SV D 
Sbjct: 426 GLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDE 485

Query: 400 DLGTADDFIG 409
           D    ++FIG
Sbjct: 486 DKFGHNEFIG 495


>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
          Length = 690

 Score =  197 bits (500), Expect = 2e-50
 Identities = 95/165 (57%), Positives = 122/165 (73%), Gaps = 5/165 (3%)

Query: 292 SARSM-----EEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPF 346
           SAR M     E+VE     EE G +L+SL YS+QQGGL+VG++RC HLA MDANGYSDPF
Sbjct: 526 SARGMALYEEEQVERVGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPF 585

Query: 347 VRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADD 406
           V+L+L P+ GKK+K KT + +KTLNPEFNEEFFY     +LA+K+L +SVWDYD+G ++D
Sbjct: 586 VKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSND 645

Query: 407 FIGGVQLGSHASGERLRHWLECLGHSDHRLELWHPLDSKPVQLSD 451
           +IGG QLG  A GERL+HW ECL + D ++E WH L ++    SD
Sbjct: 646 YIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQNENHVSSD 690



 Score =  154 bits (390), Expect = 1e-37
 Identities = 91/198 (45%), Positives = 125/198 (63%), Gaps = 19/198 (9%)

Query: 51  HP--PNLRPAAASAVRSAPQLQPDPEPEG------DSDDSTALGTLEFTLLFEADNSALH 102
           HP  P  + +AA+   +A +  P PE E       DSD++T LG LEF+LL++ DNS+L 
Sbjct: 347 HPSGPYSQASAAAPQPAAARQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQ 406

Query: 103 CTAHRAKGLKPLAS-GSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTR 161
           CT  +AKGLKP+ S G AD YVK +LLPGASK+++LRT T+R TR P+W ETL YHG T 
Sbjct: 407 CTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITD 466

Query: 162 QDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRR 221
           +D + KTLR       +VC        ++    +GE R  L+KL PN+ ++F+ICLE+  
Sbjct: 467 EDMQRKTLRI------SVCDEDKFGHNEF----IGETRFSLKKLKPNQRKNFNICLERVI 516

Query: 222 LAKRPKSLDTACGMSLYE 239
             KR  +  +A GM+LYE
Sbjct: 517 PMKRAGTTGSARGMALYE 534



 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 46/130 (35%), Positives = 66/130 (50%), Gaps = 5/130 (3%)

Query: 281 RVPSAPDPKHNSARSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDAN 340
           R P  P+ +   A S +  E        G +  SL Y      L   +++   L PMD+N
Sbjct: 366 RQPPPPEEEEEEANSYDSDEATTL----GALEFSLLYDQDNSSLQCTIIKAKGLKPMDSN 421

Query: 341 GYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSG-PREELAQKTLLVSVWDY 399
           G +DP+V+L L P A K +K +T   R T NP +NE   Y G   E++ +KTL +SV D 
Sbjct: 422 GLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDE 481

Query: 400 DLGTADDFIG 409
           D    ++FIG
Sbjct: 482 DKFGHNEFIG 491


>gi|6005997 double C2-like domains, beta [Homo sapiens]
          Length = 412

 Score =  191 bits (484), Expect = 2e-48
 Identities = 88/140 (62%), Positives = 111/140 (79%)

Query: 306 EECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSV 365
           EE G +L+SL YSSQ+ GLLVG++RCAHLA MDANGYSDP+V+ +L P+  KKSK KT+V
Sbjct: 265 EERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAV 324

Query: 366 HRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHW 425
            +KTLNPEFNEEF Y     +LA+K+L V+VWDYD+G ++DFIGGV LG HA GERL+HW
Sbjct: 325 KKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHW 384

Query: 426 LECLGHSDHRLELWHPLDSK 445
            +CL + D R+E WH L S+
Sbjct: 385 FDCLKNKDKRIERWHTLTSE 404



 Score =  184 bits (467), Expect = 1e-46
 Identities = 116/257 (45%), Positives = 148/257 (57%), Gaps = 55/257 (21%)

Query: 9   GQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHF----YPFAEP-ALHPPN--LRPAAAS 61
           G+   +S+QEHMAIDV PGPIRPI+ IS YFP F     P A P A  PP+   RPA A 
Sbjct: 7   GEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPARPAVAG 66

Query: 62  AVRSAPQ----------------------------------LQPDPEPEGD---SDDSTA 84
           A R +P                                     P+ EP+ D   SDD TA
Sbjct: 67  AGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYESDDCTA 126

Query: 85  LGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQLRTHTVR 143
           LGTL+F+LL++ +N+ALHCT  +AKGLKP+  +G AD YVK +LLPGASKA++LRT T+R
Sbjct: 127 LGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLR 186

Query: 144 GTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSLGELRVPLR 203
            T  P W ETLTY+G T +D   KTLR       +VC        ++    +GE RVPL+
Sbjct: 187 NTLNPTWNETLTYYGITDEDMIRKTLRI------SVCDEDKFRHNEF----IGETRVPLK 236

Query: 204 KLVPNRARSFDICLEKR 220
           KL PN  ++F+ICLEK+
Sbjct: 237 KLKPNHTKTFNICLEKQ 253



 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 48/136 (35%), Positives = 68/136 (50%), Gaps = 6/136 (4%)

Query: 280 PRVPSAPDPKHNSARSMEEVETEVAWE--EC---GHVLLSLCYSSQQGGLLVGVLRCAHL 334
           P     P P    A+  E+      +E  +C   G +  SL Y  +   L   + +   L
Sbjct: 94  PGPSPGPSPARPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGL 153

Query: 335 APMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSG-PREELAQKTLL 393
            PMD NG +DP+V+L L P A K +K +T   R TLNP +NE   Y G   E++ +KTL 
Sbjct: 154 KPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLR 213

Query: 394 VSVWDYDLGTADDFIG 409
           +SV D D    ++FIG
Sbjct: 214 ISVCDEDKFRHNEFIG 229



 Score = 28.9 bits (63), Expect = 10.0
 Identities = 20/64 (31%), Positives = 29/64 (45%), Gaps = 4/64 (6%)

Query: 115 ASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTY---HG-FTRQDAECKTLR 170
           A+G +D YVK  L P   K S+ +T   + T  P + E   Y   HG   ++  E     
Sbjct: 298 ANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWD 357

Query: 171 SDLG 174
            D+G
Sbjct: 358 YDIG 361


>gi|211059429 synaptotagmin II [Homo sapiens]
          Length = 419

 Score =  102 bits (254), Expect = 7e-22
 Identities = 53/137 (38%), Positives = 79/137 (57%)

Query: 306 EECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSV 365
           E+ G +  SL Y    G L V +L   +L  MD  G SDP+V++ L  N  +  K KT+V
Sbjct: 269 EKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTV 328

Query: 366 HRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHW 425
            +KTLNP FNE F +  P E++ +  ++V+V DYD    ++ IG + +GS+A+G  LRHW
Sbjct: 329 KKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHW 388

Query: 426 LECLGHSDHRLELWHPL 442
            + L +    +  WH L
Sbjct: 389 SDMLANPRRPIAQWHSL 405



 Score =  100 bits (249), Expect = 3e-21
 Identities = 56/135 (41%), Positives = 80/135 (59%), Gaps = 4/135 (2%)

Query: 298 EVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGK 357
           E E E   E  G +  SL Y  Q   L VGVL+ A L  +D  G SDP+V++FL P+  K
Sbjct: 130 EGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPD--K 187

Query: 358 KSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHA 417
           K K++T VHRKTLNP FNE F +  P +EL  KTL+++++D+D  +  D IG V++  + 
Sbjct: 188 KKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNT 247

Query: 418 --SGERLRHWLECLG 430
              G+ +  W +  G
Sbjct: 248 VDLGQPIEEWRDLQG 262



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 38/131 (29%), Positives = 59/131 (45%), Gaps = 15/131 (11%)

Query: 74  EPEGDSD-DSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGA 131
           E EG+ + +   LG L+F+L ++   + L     +A  L  L   G++D YVK  LLP  
Sbjct: 128 EGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDK 187

Query: 132 SKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQ 191
            K  + + H  R T  P + ET T+          K    +LGG   V        R  +
Sbjct: 188 KKKYETKVH--RKTLNPAFNETFTF----------KVPYQELGGKTLVMAIYDF-DRFSK 234

Query: 192 APSLGELRVPL 202
              +GE++VP+
Sbjct: 235 HDIIGEVKVPM 245


>gi|31543670 synaptotagmin II [Homo sapiens]
          Length = 419

 Score =  102 bits (254), Expect = 7e-22
 Identities = 53/137 (38%), Positives = 79/137 (57%)

Query: 306 EECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSV 365
           E+ G +  SL Y    G L V +L   +L  MD  G SDP+V++ L  N  +  K KT+V
Sbjct: 269 EKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTV 328

Query: 366 HRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHW 425
            +KTLNP FNE F +  P E++ +  ++V+V DYD    ++ IG + +GS+A+G  LRHW
Sbjct: 329 KKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHW 388

Query: 426 LECLGHSDHRLELWHPL 442
            + L +    +  WH L
Sbjct: 389 SDMLANPRRPIAQWHSL 405



 Score =  100 bits (249), Expect = 3e-21
 Identities = 56/135 (41%), Positives = 80/135 (59%), Gaps = 4/135 (2%)

Query: 298 EVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGK 357
           E E E   E  G +  SL Y  Q   L VGVL+ A L  +D  G SDP+V++FL P+  K
Sbjct: 130 EGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPD--K 187

Query: 358 KSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHA 417
           K K++T VHRKTLNP FNE F +  P +EL  KTL+++++D+D  +  D IG V++  + 
Sbjct: 188 KKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNT 247

Query: 418 --SGERLRHWLECLG 430
              G+ +  W +  G
Sbjct: 248 VDLGQPIEEWRDLQG 262



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 38/131 (29%), Positives = 59/131 (45%), Gaps = 15/131 (11%)

Query: 74  EPEGDSD-DSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGA 131
           E EG+ + +   LG L+F+L ++   + L     +A  L  L   G++D YVK  LLP  
Sbjct: 128 EGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDK 187

Query: 132 SKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQ 191
            K  + + H  R T  P + ET T+          K    +LGG   V        R  +
Sbjct: 188 KKKYETKVH--RKTLNPAFNETFTF----------KVPYQELGGKTLVMAIYDF-DRFSK 234

Query: 192 APSLGELRVPL 202
              +GE++VP+
Sbjct: 235 HDIIGEVKVPM 245


>gi|209447073 synaptotagmin I [Homo sapiens]
          Length = 422

 Score =  100 bits (248), Expect = 4e-21
 Identities = 53/113 (46%), Positives = 72/113 (63%), Gaps = 2/113 (1%)

Query: 297 EEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAG 356
           EE E     E+ G +  SL Y  Q   LLVG+++ A L  +D  G SDP+V++FL P+  
Sbjct: 132 EEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPD-- 189

Query: 357 KKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIG 409
           KK KF+T VHRKTLNP FNE+F +  P  EL  KTL+++V+D+D  +  D IG
Sbjct: 190 KKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIG 242



 Score = 99.4 bits (246), Expect = 6e-21
 Identities = 53/149 (35%), Positives = 82/149 (55%), Gaps = 1/149 (0%)

Query: 294 RSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP 353
           R ++  E E   E+ G +  SL Y    G L V +L   +L  MD  G SDP+V++ L  
Sbjct: 261 RDLQSAEKEEQ-EKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQ 319

Query: 354 NAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
           N  +  K KT++ + TLNP +NE F +  P E++ +  ++V+V DYD    +D IG V +
Sbjct: 320 NGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFV 379

Query: 414 GSHASGERLRHWLECLGHSDHRLELWHPL 442
           G +++G  LRHW + L +    +  WH L
Sbjct: 380 GYNSTGAELRHWSDMLANPRRPIAQWHTL 408



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 38/132 (28%), Positives = 59/132 (44%), Gaps = 14/132 (10%)

Query: 72  DPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPG 130
           D E + +  +   LG L+++L ++  N+ L     +A  L  L   G++D YVK  LLP 
Sbjct: 130 DGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPD 189

Query: 131 ASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQW 190
             K  + + H  R T  PV+ E  T+          K   S+LGG   V        R  
Sbjct: 190 KKKKFETKVH--RKTLNPVFNEQFTF----------KVPYSELGGKTLVMAVYDF-DRFS 236

Query: 191 QAPSLGELRVPL 202
           +   +GE +VP+
Sbjct: 237 KHDIIGEFKVPM 248


>gi|5032139 synaptotagmin I [Homo sapiens]
          Length = 422

 Score =  100 bits (248), Expect = 4e-21
 Identities = 53/113 (46%), Positives = 72/113 (63%), Gaps = 2/113 (1%)

Query: 297 EEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAG 356
           EE E     E+ G +  SL Y  Q   LLVG+++ A L  +D  G SDP+V++FL P+  
Sbjct: 132 EEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPD-- 189

Query: 357 KKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIG 409
           KK KF+T VHRKTLNP FNE+F +  P  EL  KTL+++V+D+D  +  D IG
Sbjct: 190 KKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIG 242



 Score = 99.4 bits (246), Expect = 6e-21
 Identities = 53/149 (35%), Positives = 82/149 (55%), Gaps = 1/149 (0%)

Query: 294 RSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP 353
           R ++  E E   E+ G +  SL Y    G L V +L   +L  MD  G SDP+V++ L  
Sbjct: 261 RDLQSAEKEEQ-EKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQ 319

Query: 354 NAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
           N  +  K KT++ + TLNP +NE F +  P E++ +  ++V+V DYD    +D IG V +
Sbjct: 320 NGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFV 379

Query: 414 GSHASGERLRHWLECLGHSDHRLELWHPL 442
           G +++G  LRHW + L +    +  WH L
Sbjct: 380 GYNSTGAELRHWSDMLANPRRPIAQWHTL 408



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 38/132 (28%), Positives = 59/132 (44%), Gaps = 14/132 (10%)

Query: 72  DPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPG 130
           D E + +  +   LG L+++L ++  N+ L     +A  L  L   G++D YVK  LLP 
Sbjct: 130 DGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPD 189

Query: 131 ASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQW 190
             K  + + H  R T  PV+ E  T+          K   S+LGG   V        R  
Sbjct: 190 KKKKFETKVH--RKTLNPVFNEQFTF----------KVPYSELGGKTLVMAVYDF-DRFS 236

Query: 191 QAPSLGELRVPL 202
           +   +GE +VP+
Sbjct: 237 KHDIIGEFKVPM 248


>gi|209447070 synaptotagmin I [Homo sapiens]
          Length = 422

 Score =  100 bits (248), Expect = 4e-21
 Identities = 53/113 (46%), Positives = 72/113 (63%), Gaps = 2/113 (1%)

Query: 297 EEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAG 356
           EE E     E+ G +  SL Y  Q   LLVG+++ A L  +D  G SDP+V++FL P+  
Sbjct: 132 EEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPD-- 189

Query: 357 KKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIG 409
           KK KF+T VHRKTLNP FNE+F +  P  EL  KTL+++V+D+D  +  D IG
Sbjct: 190 KKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIG 242



 Score = 99.4 bits (246), Expect = 6e-21
 Identities = 53/149 (35%), Positives = 82/149 (55%), Gaps = 1/149 (0%)

Query: 294 RSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP 353
           R ++  E E   E+ G +  SL Y    G L V +L   +L  MD  G SDP+V++ L  
Sbjct: 261 RDLQSAEKEEQ-EKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQ 319

Query: 354 NAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
           N  +  K KT++ + TLNP +NE F +  P E++ +  ++V+V DYD    +D IG V +
Sbjct: 320 NGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFV 379

Query: 414 GSHASGERLRHWLECLGHSDHRLELWHPL 442
           G +++G  LRHW + L +    +  WH L
Sbjct: 380 GYNSTGAELRHWSDMLANPRRPIAQWHTL 408



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 38/132 (28%), Positives = 59/132 (44%), Gaps = 14/132 (10%)

Query: 72  DPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPG 130
           D E + +  +   LG L+++L ++  N+ L     +A  L  L   G++D YVK  LLP 
Sbjct: 130 DGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPD 189

Query: 131 ASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQW 190
             K  + + H  R T  PV+ E  T+          K   S+LGG   V        R  
Sbjct: 190 KKKKFETKVH--RKTLNPVFNEQFTF----------KVPYSELGGKTLVMAVYDF-DRFS 236

Query: 191 QAPSLGELRVPL 202
           +   +GE +VP+
Sbjct: 237 KHDIIGEFKVPM 248


>gi|45504376 synaptotagmin VI [Homo sapiens]
          Length = 425

 Score = 99.4 bits (246), Expect = 6e-21
 Identities = 50/136 (36%), Positives = 76/136 (55%)

Query: 307 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVH 366
           + G ++ SLCY    G L + V++C +L  MD  GYSDP+V++ L  +  +  K KT++ 
Sbjct: 276 DLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIK 335

Query: 367 RKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWL 426
           + TLNP +NE   +  P E + Q +LL+SV DYD    ++ IG  ++G  A G    HW 
Sbjct: 336 KNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIGVCRVGITAEGLGRDHWN 395

Query: 427 ECLGHSDHRLELWHPL 442
           E L +    +  WH L
Sbjct: 396 EMLAYPRKPIAHWHSL 411



 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 49/117 (41%), Positives = 72/117 (61%), Gaps = 3/117 (2%)

Query: 297 EEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAG 356
           E+ ++E A + CG +  SL Y  +   L+V +L+   L   D  G SDP+V+++L P+  
Sbjct: 135 EDAKSE-ATKSCGKINFSLRYDYETETLIVRILKAFDLPAKDFCGSSDPYVKIYLLPD-- 191

Query: 357 KKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
           +K K +T VHRKTLNP F+E F +  P EELA + L +SV+D+D  +  D IG V L
Sbjct: 192 RKCKLQTRVHRKTLNPTFDENFHFPVPYEELADRKLHLSVFDFDRFSRHDMIGEVIL 248



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 1/79 (1%)

Query: 79  SDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQL 137
           + +S  LG + F+L +      L  T  + + LK +  +G +D YVK +LL    +  + 
Sbjct: 271 TSESVDLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKK 330

Query: 138 RTHTVRGTRVPVWEETLTY 156
           +T   + T  PV+ E + +
Sbjct: 331 KTTIKKNTLNPVYNEAIIF 349



 Score = 33.5 bits (75), Expect = 0.40
 Identities = 32/109 (29%), Positives = 48/109 (44%), Gaps = 9/109 (8%)

Query: 55  LRPAA---ASAVRSAPQLQPDPEPEGD---SDDSTALGTLEFTLLFEADNSALHCTAHRA 108
           L PAA    S  R  P+L      +G+   S+ + + G + F+L ++ +   L     +A
Sbjct: 109 LPPAAEQPTSIGRIKPELYKQKSVDGEDAKSEATKSCGKINFSLRYDYETETLIVRILKA 168

Query: 109 KGLKPLA-SGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTY 156
             L      GS+D YVK  LLP      Q R H  R T  P ++E   +
Sbjct: 169 FDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVH--RKTLNPTFDENFHF 215


>gi|238550198 synaptotagmin III [Homo sapiens]
          Length = 590

 Score = 93.2 bits (230), Expect = 4e-19
 Identities = 49/106 (46%), Positives = 68/106 (64%), Gaps = 2/106 (1%)

Query: 308 CGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHR 367
           CG +  +L Y      L+V +L+   L   D+NG+SDP+V+++L P+  +K KF+T VHR
Sbjct: 300 CGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPD--RKKKFQTKVHR 357

Query: 368 KTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
           KTLNP FNE F +S P  ELAQ+ L  SV+D+D  +  D IG V L
Sbjct: 358 KTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVL 403



 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 46/137 (33%), Positives = 71/137 (51%), Gaps = 1/137 (0%)

Query: 307 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVH 366
           + G +  SLCY    G L V +++ ++L  MD  G+SDP+V+  L     +  K KTS+ 
Sbjct: 431 DLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIK 490

Query: 367 RKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLR-HW 425
           + TLNP +NE   +    E +    L ++V DYD    ++ IG  ++G  A+    R HW
Sbjct: 491 KNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHW 550

Query: 426 LECLGHSDHRLELWHPL 442
            E L +    +E WH L
Sbjct: 551 AEMLANPRKPVEHWHQL 567



 Score = 37.7 bits (86), Expect = 0.021
 Identities = 25/82 (30%), Positives = 41/82 (50%), Gaps = 2/82 (2%)

Query: 76  EGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKA 134
           EG S+ +  LG L F+L +      L  T  +A  LK +  +G +D YVKA+L+    + 
Sbjct: 424 EGGSEKAD-LGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRL 482

Query: 135 SQLRTHTVRGTRVPVWEETLTY 156
            + +T   + T  P + E L +
Sbjct: 483 KKRKTSIKKNTLNPTYNEALVF 504



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 25/81 (30%), Positives = 35/81 (43%), Gaps = 3/81 (3%)

Query: 77  GDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLAS-GSADAYVKANLLPGASKAS 135
           G++      G + F L +   +  L     +A  L    S G +D YVK  LLP   K  
Sbjct: 292 GEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKF 351

Query: 136 QLRTHTVRGTRVPVWEETLTY 156
           Q + H  R T  PV+ ET  +
Sbjct: 352 QTKVH--RKTLNPVFNETFQF 370


>gi|238550196 synaptotagmin III [Homo sapiens]
          Length = 590

 Score = 93.2 bits (230), Expect = 4e-19
 Identities = 49/106 (46%), Positives = 68/106 (64%), Gaps = 2/106 (1%)

Query: 308 CGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHR 367
           CG +  +L Y      L+V +L+   L   D+NG+SDP+V+++L P+  +K KF+T VHR
Sbjct: 300 CGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPD--RKKKFQTKVHR 357

Query: 368 KTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
           KTLNP FNE F +S P  ELAQ+ L  SV+D+D  +  D IG V L
Sbjct: 358 KTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVL 403



 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 46/137 (33%), Positives = 71/137 (51%), Gaps = 1/137 (0%)

Query: 307 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVH 366
           + G +  SLCY    G L V +++ ++L  MD  G+SDP+V+  L     +  K KTS+ 
Sbjct: 431 DLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIK 490

Query: 367 RKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLR-HW 425
           + TLNP +NE   +    E +    L ++V DYD    ++ IG  ++G  A+    R HW
Sbjct: 491 KNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHW 550

Query: 426 LECLGHSDHRLELWHPL 442
            E L +    +E WH L
Sbjct: 551 AEMLANPRKPVEHWHQL 567



 Score = 37.7 bits (86), Expect = 0.021
 Identities = 25/82 (30%), Positives = 41/82 (50%), Gaps = 2/82 (2%)

Query: 76  EGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKA 134
           EG S+ +  LG L F+L +      L  T  +A  LK +  +G +D YVKA+L+    + 
Sbjct: 424 EGGSEKAD-LGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRL 482

Query: 135 SQLRTHTVRGTRVPVWEETLTY 156
            + +T   + T  P + E L +
Sbjct: 483 KKRKTSIKKNTLNPTYNEALVF 504



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 25/81 (30%), Positives = 35/81 (43%), Gaps = 3/81 (3%)

Query: 77  GDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLAS-GSADAYVKANLLPGASKAS 135
           G++      G + F L +   +  L     +A  L    S G +D YVK  LLP   K  
Sbjct: 292 GEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKF 351

Query: 136 QLRTHTVRGTRVPVWEETLTY 156
           Q + H  R T  PV+ ET  +
Sbjct: 352 QTKVH--RKTLNPVFNETFQF 370


>gi|14150054 synaptotagmin III [Homo sapiens]
          Length = 590

 Score = 93.2 bits (230), Expect = 4e-19
 Identities = 49/106 (46%), Positives = 68/106 (64%), Gaps = 2/106 (1%)

Query: 308 CGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHR 367
           CG +  +L Y      L+V +L+   L   D+NG+SDP+V+++L P+  +K KF+T VHR
Sbjct: 300 CGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPD--RKKKFQTKVHR 357

Query: 368 KTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
           KTLNP FNE F +S P  ELAQ+ L  SV+D+D  +  D IG V L
Sbjct: 358 KTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVL 403



 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 46/137 (33%), Positives = 71/137 (51%), Gaps = 1/137 (0%)

Query: 307 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVH 366
           + G +  SLCY    G L V +++ ++L  MD  G+SDP+V+  L     +  K KTS+ 
Sbjct: 431 DLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIK 490

Query: 367 RKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLR-HW 425
           + TLNP +NE   +    E +    L ++V DYD    ++ IG  ++G  A+    R HW
Sbjct: 491 KNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHW 550

Query: 426 LECLGHSDHRLELWHPL 442
            E L +    +E WH L
Sbjct: 551 AEMLANPRKPVEHWHQL 567



 Score = 37.7 bits (86), Expect = 0.021
 Identities = 25/82 (30%), Positives = 41/82 (50%), Gaps = 2/82 (2%)

Query: 76  EGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKA 134
           EG S+ +  LG L F+L +      L  T  +A  LK +  +G +D YVKA+L+    + 
Sbjct: 424 EGGSEKAD-LGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRL 482

Query: 135 SQLRTHTVRGTRVPVWEETLTY 156
            + +T   + T  P + E L +
Sbjct: 483 KKRKTSIKKNTLNPTYNEALVF 504



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 25/81 (30%), Positives = 35/81 (43%), Gaps = 3/81 (3%)

Query: 77  GDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLAS-GSADAYVKANLLPGASKAS 135
           G++      G + F L +   +  L     +A  L    S G +D YVK  LLP   K  
Sbjct: 292 GEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKF 351

Query: 136 QLRTHTVRGTRVPVWEETLTY 156
           Q + H  R T  PV+ ET  +
Sbjct: 352 QTKVH--RKTLNPVFNETFQF 370


>gi|39752671 synaptotagmin X [Homo sapiens]
          Length = 523

 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 48/140 (34%), Positives = 73/140 (52%)

Query: 307 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVH 366
           + G ++ SLCY    G + + V++C +L  MD  G SDP+V++ L     +  K KT+  
Sbjct: 363 DLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTTTK 422

Query: 367 RKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWL 426
           + TLNP +NE   +  P E + Q +L ++V DYD    ++ IG  + G  A G    HW 
Sbjct: 423 KNTLNPVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWN 482

Query: 427 ECLGHSDHRLELWHPLDSKP 446
           E L +    +  WHPL   P
Sbjct: 483 EMLAYHRKPITHWHPLLELP 502



 Score = 75.9 bits (185), Expect = 7e-14
 Identities = 41/106 (38%), Positives = 64/106 (60%), Gaps = 2/106 (1%)

Query: 308 CGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHR 367
           CG +  +L Y  +   L+V +++   L   D  G SDP+V+++L P+  +K KF+T VHR
Sbjct: 232 CGKLNFTLQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKMYLLPD--RKKKFQTRVHR 289

Query: 368 KTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
           KTLNP F+E F +    ++L+ + L  SV+D+D  +  D IG V L
Sbjct: 290 KTLNPLFDETFQFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVIL 335



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 32/97 (32%), Positives = 49/97 (50%), Gaps = 6/97 (6%)

Query: 64  RSAPQL--QPDPEPEGDSDDSTAL-GTLEFTLLFEADNSALHCTAHRAKGLKPLA-SGSA 119
           R  P+L  Q   + EG+ ++   + G L FTL ++ +N  L     +A  L     +G++
Sbjct: 208 RIKPELYKQKSVDSEGNQNEDVKICGKLNFTLQYDYENELLVVKIIKALDLPAKDFTGTS 267

Query: 120 DAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTY 156
           D YVK  LLP   K  Q R H  R T  P+++ET  +
Sbjct: 268 DPYVKMYLLPDRKKKFQTRVH--RKTLNPLFDETFQF 302



 Score = 37.4 bits (85), Expect = 0.028
 Identities = 21/77 (27%), Positives = 40/77 (51%), Gaps = 1/77 (1%)

Query: 81  DSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQLRT 139
           +S  LG + F+L +      +  T  + + LK +  +GS+D YVK +L+    +  + +T
Sbjct: 360 ESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKT 419

Query: 140 HTVRGTRVPVWEETLTY 156
            T + T  PV+ E + +
Sbjct: 420 TTKKNTLNPVYNEAIIF 436


>gi|92859638 synaptotagmin V [Homo sapiens]
          Length = 386

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 50/123 (40%), Positives = 76/123 (61%), Gaps = 4/123 (3%)

Query: 307 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVH 366
           E G +  SL Y  Q G LLVG+L+   LA +D  G SDP+VR++L P+  K+ +++T VH
Sbjct: 108 ELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPD--KRRRYETKVH 165

Query: 367 RKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQ--LGSHASGERLRH 424
           R+TLNP F E F +  P  EL  + L+++V+D+D  + +D IG V+  + S   G  ++ 
Sbjct: 166 RQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQA 225

Query: 425 WLE 427
           W E
Sbjct: 226 WRE 228



 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 49/137 (35%), Positives = 74/137 (54%)

Query: 306 EECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSV 365
           E+ G +  SL Y    G L V VL   +L  MD  G SDP+V++ L     K  K KT++
Sbjct: 238 EKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTI 297

Query: 366 HRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHW 425
            + TLNP +NE F +  P +++ +  + ++V DYD    ++ IG V +G+ A G  LRHW
Sbjct: 298 KKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRHW 357

Query: 426 LECLGHSDHRLELWHPL 442
            + L +    +  WH L
Sbjct: 358 ADMLANPRRPIAQWHSL 374



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 39/137 (28%), Positives = 61/137 (44%), Gaps = 15/137 (10%)

Query: 68  QLQPDPEPEGDS-DDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKA 125
           +L+P P   G    D   LG L+++L ++  +  L     +A GL  L   GS+D YV+ 
Sbjct: 91  ELEPAPSGPGQQVADKHELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRV 150

Query: 126 NLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPM 185
            LLP   +  + + H  R T  P + ET  +          K    +LGG   V      
Sbjct: 151 YLLPDKRRRYETKVH--RQTLNPHFGETFAF----------KVPYVELGGRVLVMAVYDF 198

Query: 186 VQRQWQAPSLGELRVPL 202
             R  +  ++GE+RVP+
Sbjct: 199 -DRFSRNDAIGEVRVPM 214


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 93/317 (29%), Positives = 144/317 (45%), Gaps = 52/317 (16%)

Query: 113  PLASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEET-LTYHGFTRQDAECKTLRS 171
            P  SG   AY+ A +LPG S  ++     + G +V  W    LT    ++   E +++ S
Sbjct: 4524 PGHSGEIGAYI-AKILPGGS--AEQTGKLMEGMQVLEWNGIPLT----SKTYEEVQSIIS 4576

Query: 172  DLGGHQAVCVRGP--MVQRQWQAPSLGELRVPLRKLVPNRARSFD-----ICLEKRRLAK 224
               G   +CVR    M+     +  L EL  P + +   ++   D       L+K  L +
Sbjct: 4577 QQSGEAEICVRLDLNMLSDSENSQHL-ELHEPPKAVDKAKSPGVDPKQLAAELQKVSLQQ 4635

Query: 225  RPKSLDTACGMSLYEVVPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPS 284
             P  L +        V  G+    G TS  S  +  P                 QP  PS
Sbjct: 4636 SPLVLSSV-------VEKGSHVHSGPTSAGSSSVPSPG----------------QPGSPS 4672

Query: 285  APDPKHNSARSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSD 344
                KH S++  +  +  V+    G + L + Y    G L++ +L+  +L P D NGYSD
Sbjct: 4673 VSKKKHGSSKPTDGTKV-VSHPITGEIQLQINYDL--GNLIIHILQARNLVPRDNNGYSD 4729

Query: 345  PFVRLFLHP---------NAGKKSKFKTSVHRKTLNPEFNEEFFY-SGPREELAQKTLLV 394
            PFV+++L P         NA  + K +T   +K+LNPE+N+   Y S   E+L +KTL V
Sbjct: 4730 PFVKVYLLPGRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEV 4789

Query: 395  SVWDYDLGTADDFIGGV 411
            +VWDYD  +++DF+G V
Sbjct: 4790 TVWDYDRFSSNDFLGEV 4806



 Score = 35.8 bits (81), Expect = 0.082
 Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 12/94 (12%)

Query: 86   GTLEFTLLFEADNSALHCTAHRAKGLKPLAS-GSADAYVKANLLPG---------ASKAS 135
            G ++  + ++  N  +H    +A+ L P  + G +D +VK  LLPG         AS   
Sbjct: 4696 GEIQLQINYDLGNLIIHIL--QARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEY 4753

Query: 136  QLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTL 169
            + RT  V+ +  P W +T+ Y   + +  + KTL
Sbjct: 4754 KRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTL 4787


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 93/317 (29%), Positives = 144/317 (45%), Gaps = 52/317 (16%)

Query: 113  PLASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEET-LTYHGFTRQDAECKTLRS 171
            P  SG   AY+ A +LPG S  ++     + G +V  W    LT    ++   E +++ S
Sbjct: 4524 PGHSGEIGAYI-AKILPGGS--AEQTGKLMEGMQVLEWNGIPLT----SKTYEEVQSIIS 4576

Query: 172  DLGGHQAVCVRGP--MVQRQWQAPSLGELRVPLRKLVPNRARSFD-----ICLEKRRLAK 224
               G   +CVR    M+     +  L EL  P + +   ++   D       L+K  L +
Sbjct: 4577 QQSGEAEICVRLDLNMLSDSENSQHL-ELHEPPKAVDKAKSPGVDPKQLAAELQKVSLQQ 4635

Query: 225  RPKSLDTACGMSLYEVVPGAPPPGGATSCCSCRLAKPKWLKPTKVAWTGHFTQRQPRVPS 284
             P  L +        V  G+    G TS  S  +  P                 QP  PS
Sbjct: 4636 SPLVLSSV-------VEKGSHVHSGPTSAGSSSVPSPG----------------QPGSPS 4672

Query: 285  APDPKHNSARSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSD 344
                KH S++  +  +  V+    G + L + Y    G L++ +L+  +L P D NGYSD
Sbjct: 4673 VSKKKHGSSKPTDGTKV-VSHPITGEIQLQINYDL--GNLIIHILQARNLVPRDNNGYSD 4729

Query: 345  PFVRLFLHP---------NAGKKSKFKTSVHRKTLNPEFNEEFFY-SGPREELAQKTLLV 394
            PFV+++L P         NA  + K +T   +K+LNPE+N+   Y S   E+L +KTL V
Sbjct: 4730 PFVKVYLLPGRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEV 4789

Query: 395  SVWDYDLGTADDFIGGV 411
            +VWDYD  +++DF+G V
Sbjct: 4790 TVWDYDRFSSNDFLGEV 4806



 Score = 35.8 bits (81), Expect = 0.082
 Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 12/94 (12%)

Query: 86   GTLEFTLLFEADNSALHCTAHRAKGLKPLAS-GSADAYVKANLLPG---------ASKAS 135
            G ++  + ++  N  +H    +A+ L P  + G +D +VK  LLPG         AS   
Sbjct: 4696 GEIQLQINYDLGNLIIHIL--QARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEY 4753

Query: 136  QLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTL 169
            + RT  V+ +  P W +T+ Y   + +  + KTL
Sbjct: 4754 KRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTL 4787


>gi|38570146 synaptotagmin VII [Homo sapiens]
          Length = 403

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 43/134 (32%), Positives = 74/134 (55%)

Query: 309 GHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRK 368
           G +LLSLCY+     ++V +++  +L  MD  G SDP+V+++L     +  K KT   ++
Sbjct: 268 GELLLSLCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKR 327

Query: 369 TLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLEC 428
            LNP FNE F +  P E+L + T++++V D D  + +D IG + L   +    ++HW + 
Sbjct: 328 NLNPIFNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKSGPGEVKHWKDM 387

Query: 429 LGHSDHRLELWHPL 442
           +      +  WH L
Sbjct: 388 IARPRQPVAQWHQL 401



 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 44/118 (37%), Positives = 68/118 (57%), Gaps = 3/118 (2%)

Query: 297 EEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAG 356
           +E     + E  G +  S+ Y+ Q+  L V +++   L   D +G SDPFV+++L P+  
Sbjct: 125 DEAHEGCSRENLGRIQFSVGYNFQESTLTVKIMKAQELPAKDFSGTSDPFVKIYLLPD-- 182

Query: 357 KKSKFKTSVHRKTLNPEFNEEFFYSG-PREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
           KK K +T V RK LNP +NE F + G P E++ Q+ L + V DYD  + +D IG V +
Sbjct: 183 KKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSI 240



 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 38/149 (25%), Positives = 65/149 (43%), Gaps = 15/149 (10%)

Query: 66  APQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLA-SGSADAYVK 124
           +P  + D   EG S ++  LG ++F++ +    S L     +A+ L     SG++D +VK
Sbjct: 119 SPGSEEDEAHEGCSREN--LGRIQFSVGYNFQESTLTVKIMKAQELPAKDFSGTSDPFVK 176

Query: 125 ANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGP 184
             LLP   K  +L T   R    P W ET  + GF  +    + L   +  +       P
Sbjct: 177 IYLLP--DKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDP 234

Query: 185 MVQRQWQAPSLGELRVPLRKLVPNRARSF 213
                     +GE+ +PL K+   + ++F
Sbjct: 235 ----------IGEVSIPLNKVDLTQMQTF 253



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 1/79 (1%)

Query: 79  SDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQL 137
           SD S + G L  +L +    +++     +A+ LK +   G++D YVK  L+    +  + 
Sbjct: 261 SDGSGSRGELLLSLCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKK 320

Query: 138 RTHTVRGTRVPVWEETLTY 156
           +T T++    P++ E+  +
Sbjct: 321 KTVTMKRNLNPIFNESFAF 339


>gi|28376627 synaptotagmin IX [Homo sapiens]
          Length = 491

 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 48/139 (34%), Positives = 72/139 (51%)

Query: 307 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVH 366
           + G ++ SLCY    G L + +++  +L  MD  G SDP+V++ L  +  +  K KTS  
Sbjct: 352 DLGELMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTK 411

Query: 367 RKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWL 426
           R TLNP +NE   +  P E + Q  L ++V DYD    ++ IG  Q+G+ A      HW 
Sbjct: 412 RNTLNPVYNEAIVFDVPPENIDQIHLSIAVMDYDRVGHNEIIGVCQVGNEAERLGRDHWS 471

Query: 427 ECLGHSDHRLELWHPLDSK 445
           E L +    +  WH L  K
Sbjct: 472 EMLSYPRKPIAHWHSLVEK 490



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 40/104 (38%), Positives = 61/104 (58%), Gaps = 2/104 (1%)

Query: 308 CGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHR 367
           CG +   L Y      L+V + +  +L   D +G SDP+V+++L P+  +K+K +T VHR
Sbjct: 221 CGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPD--RKTKHQTKVHR 278

Query: 368 KTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGV 411
           KTLNP F+E F +  P  +L  + L  SV+D+D  +  D IG V
Sbjct: 279 KTLNPVFDEVFLFPVPYNDLEARKLHFSVYDFDRFSRHDLIGQV 322



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 24/79 (30%), Positives = 43/79 (54%), Gaps = 1/79 (1%)

Query: 79  SDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQL 137
           ++D+  LG L F+L +      L  T  +A+ LK +  +G++D YVK +L+    +  + 
Sbjct: 347 TNDNVDLGELMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKR 406

Query: 138 RTHTVRGTRVPVWEETLTY 156
           +T T R T  PV+ E + +
Sbjct: 407 KTSTKRNTLNPVYNEAIVF 425



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 28/82 (34%), Positives = 39/82 (47%), Gaps = 3/82 (3%)

Query: 76  EGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLA-SGSADAYVKANLLPGASKA 134
           +G   +S A G L F L ++ D   L    H+A  L     SG++D YVK  LLP     
Sbjct: 212 DGRRSNSKACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTK 271

Query: 135 SQLRTHTVRGTRVPVWEETLTY 156
            Q + H  R T  PV++E   +
Sbjct: 272 HQTKVH--RKTLNPVFDEVFLF 291


>gi|40068038 B/K protein [Homo sapiens]
          Length = 474

 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 50/140 (35%), Positives = 76/140 (54%), Gaps = 1/140 (0%)

Query: 307 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVH 366
           E G +LLSL Y    G L V V+R   L   D +  SDPFV++ L          KTS  
Sbjct: 321 ELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFL 380

Query: 367 RKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASG-ERLRHW 425
           R T++P +NE F +  P+EEL   +L+ +V+ +++ +++DFIG + +G ++SG     HW
Sbjct: 381 RGTIDPFYNESFSFKVPQEELENASLVFTVFGHNMKSSNDFIGRIVIGQYSSGPSETNHW 440

Query: 426 LECLGHSDHRLELWHPLDSK 445
              L      +E WH L S+
Sbjct: 441 RRMLNTHRTAVEQWHSLRSR 460



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 33/114 (28%), Positives = 56/114 (49%), Gaps = 9/114 (7%)

Query: 307 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDAN-------GYSDPFVRLFLHPNAGKKS 359
           + G +  S  Y      L V V+    L P  ++        +S+P+V++ L P+  +K+
Sbjct: 184 QLGMLHFSTQYDLLHNHLTVRVIEARDLPPPISHDGSRQDMAHSNPYVKICLLPD--QKN 241

Query: 360 KFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
             +T V RKT  P F E + +  P  E  ++TLL++V D+D  +    IG V +
Sbjct: 242 SKQTGVKRKTQKPVFEERYTFEIPFLEAQRRTLLLTVVDFDKFSRHCVIGKVSV 295



 Score = 30.8 bits (68), Expect = 2.6
 Identities = 26/99 (26%), Positives = 44/99 (44%), Gaps = 2/99 (2%)

Query: 79  SDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQL 137
           S +   LG L  +L +      L+    RAK L     S  +D +VK  L+ G       
Sbjct: 316 SQNEVELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTK 375

Query: 138 RTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGH 176
           +T  +RGT  P + E+ ++    +++ E  +L   + GH
Sbjct: 376 KTSFLRGTIDPFYNESFSFK-VPQEELENASLVFTVFGH 413


>gi|24308219 synaptotagmin IV [Homo sapiens]
          Length = 425

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 49/134 (36%), Positives = 71/134 (52%)

Query: 309 GHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRK 368
           G +L+SLCY S    L V VL+  HL   D +G SDP+V++ L+    + SK KT V + 
Sbjct: 289 GELLISLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTHVKKC 348

Query: 369 TLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLEC 428
           T N  FNE F +  P E L   ++   V D + G+ ++ IG + LG+ A G    HW E 
Sbjct: 349 TPNAVFNELFVFDIPCEGLEDISVEFLVLDSERGSRNEVIGQLVLGAAAEGTGGEHWKEI 408

Query: 429 LGHSDHRLELWHPL 442
             +   ++  WH L
Sbjct: 409 CDYPRRQIAKWHVL 422



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 40/122 (32%), Positives = 64/122 (52%), Gaps = 4/122 (3%)

Query: 292 SARSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGY-SDPFVRLF 350
           S +S   + +E   E+ G +  SL Y+ ++   +V +     L  MD     SDP++++ 
Sbjct: 138 SLKSSTSLTSEEKQEKLGTLFFSLEYNFERKAFVVNIKEARGLPAMDEQSMTSDPYIKMT 197

Query: 351 LHPNAGKKSKFKTSVHRKTLNPEFNEEF-FYSGPREELAQKTLLVSVWDYDLGTADDFIG 409
           + P   KK K KT V RKTL+P F+E F FY  P  ++ +  L  ++  +D  + DD IG
Sbjct: 198 ILPE--KKHKVKTRVLRKTLDPAFDETFTFYGIPYTQIQELALHFTILSFDRFSRDDIIG 255

Query: 410 GV 411
            V
Sbjct: 256 EV 257



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 36/121 (29%), Positives = 60/121 (49%), Gaps = 18/121 (14%)

Query: 54  NLRPAAASAVRSA-PQLQPDPEPEGDSDDSTA-------------LGTLEFTLLFEADNS 99
           NL+P + S + +A P+L  + E E  S +S               LGTL F+L +  +  
Sbjct: 109 NLKPGSPSDLENATPKLFLEGEKESVSPESLKSSTSLTSEEKQEKLGTLFFSLEYNFERK 168

Query: 100 ALHCTAHRAKGLKPL--ASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYH 157
           A       A+GL  +   S ++D Y+K  +LP   K  +++T  +R T  P ++ET T++
Sbjct: 169 AFVVNIKEARGLPAMDEQSMTSDPYIKMTILP--EKKHKVKTRVLRKTLDPAFDETFTFY 226

Query: 158 G 158
           G
Sbjct: 227 G 227



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 28/103 (27%), Positives = 44/103 (42%), Gaps = 5/103 (4%)

Query: 82  STALGTLEFTLLFEADNSALHCTAHRAKGL-KPLASGSADAYVKANLLPGASKASQLRTH 140
           S+  G L  +L +++  + L     +A+ L K   SG +D YVK NL     + S+ +TH
Sbjct: 285 SSGRGELLISLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTH 344

Query: 141 TVRGTRVPVWEETLTY----HGFTRQDAECKTLRSDLGGHQAV 179
             + T   V+ E   +     G      E   L S+ G    V
Sbjct: 345 VKKCTPNAVFNELFVFDIPCEGLEDISVEFLVLDSERGSRNEV 387


>gi|94536846 synaptotagmin VIII [Homo sapiens]
          Length = 401

 Score = 82.4 bits (202), Expect = 8e-16
 Identities = 48/137 (35%), Positives = 71/137 (51%), Gaps = 4/137 (2%)

Query: 306 EECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSV 365
           E+ G +  SL Y    G L V VL    L P    G ++P+V++ L  N  K  K KT+ 
Sbjct: 244 EQVGELCFSLRYVPSSGRLTVVVLEARGLRP----GLAEPYVKVQLMLNQRKWKKRKTAT 299

Query: 366 HRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHW 425
            + T  P FNE F +  P  ++    L+++VWD  L    + +G V LG+ ASG+ L+HW
Sbjct: 300 KKGTAAPYFNEAFTFLVPFSQVQNVDLVLAVWDRSLPLRTEPVGKVHLGARASGQPLQHW 359

Query: 426 LECLGHSDHRLELWHPL 442
            + L H+   +   HPL
Sbjct: 360 ADMLAHARRPIAQRHPL 376



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 36/122 (29%), Positives = 61/122 (50%), Gaps = 7/122 (5%)

Query: 306 EECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSV 365
           ++ G + LSL +      + VG+ + A L P    G  DP+ R+ +   AG + +  T V
Sbjct: 116 QQWGRLQLSLEFDFGSQEIRVGLRQAADLRP---GGTVDPYARVSVSTQAGHRHE--TKV 170

Query: 366 HRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQ--LGSHASGERLR 423
           HR TL P F+E   +  P+ EL   TL V ++++   +  + +G ++  LG+      L 
Sbjct: 171 HRGTLCPVFDETCCFHIPQAELPGATLQVQLFNFKRFSGHEPLGELRLPLGTVDLQHVLE 230

Query: 424 HW 425
           HW
Sbjct: 231 HW 232



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 36/135 (26%), Positives = 60/135 (44%), Gaps = 16/135 (11%)

Query: 69  LQPDPEP-EGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSADAYVKANL 127
           +QPD +  E    D+   G L+ +L F+  +  +     +A  L+P   G+ D Y + ++
Sbjct: 101 VQPDVDGLESSPGDAQQWGRLQLSLEFDFGSQEIRVGLRQAADLRP--GGTVDPYARVSV 158

Query: 128 LPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQ 187
              A    + + H  RGT  PV++ET  +H   + +    TL+  L   +      P   
Sbjct: 159 STQAGHRHETKVH--RGTLCPVFDETCCFH-IPQAELPGATLQVQLFNFKRFSGHEP--- 212

Query: 188 RQWQAPSLGELRVPL 202
                  LGELR+PL
Sbjct: 213 -------LGELRLPL 220



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 23/72 (31%), Positives = 36/72 (50%), Gaps = 3/72 (4%)

Query: 85  LGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSADAYVKANLLPGASKASQLRTHTVRG 144
           +G L F+L +   +  L      A+GL+P   G A+ YVK  L+    K  + +T T +G
Sbjct: 246 VGELCFSLRYVPSSGRLTVVVLEARGLRP---GLAEPYVKVQLMLNQRKWKKRKTATKKG 302

Query: 145 TRVPVWEETLTY 156
           T  P + E  T+
Sbjct: 303 TAAPYFNEAFTF 314


>gi|45387945 family with sequence similarity 62 (C2 domain
           containing) member B [Homo sapiens]
          Length = 893

 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 84/316 (26%), Positives = 128/316 (40%), Gaps = 84/316 (26%)

Query: 145 TRVPVWEETLTY--HGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSLGELRVPL 202
           T  PVWEE  T+  H   RQD E +                  V+ +    SLG L+VPL
Sbjct: 551 TNEPVWEENFTFFIHNPKRQDLEVE------------------VRDEQHQCSLGNLKVPL 592

Query: 203 RKLV-----------------PNRARSFDICL-----EKRRL---------AKRPKSLDT 231
            +L+                 PN      I L     EKR            KRP     
Sbjct: 593 SQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKE 652

Query: 232 ACGMSLYEVVPGAPPPGGATSCCSCRL------------AKPKWLKP-----------TK 268
               S+   + G+P PGG+ +  S  +            A+P    P           + 
Sbjct: 653 GRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSL 712

Query: 269 VAWTGHFTQRQPR--------VPSAPDPKHNSARSMEEVETEVAWEECGHVLLSLCYSSQ 320
           +A  GH + ++P         +P A        R +E   T +     G + L++ +SSQ
Sbjct: 713 LASPGHISVKEPTPSIASDISLPIATQELRQRLRQLEN-GTTLGQSPLGQIQLTIRHSSQ 771

Query: 321 QGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFY 380
           +  L+V V  C +L     +G SDP+VR++L P+  +  + KT V +KTLNP F++ F +
Sbjct: 772 RNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDF 830

Query: 381 SGPREELAQKTLLVSV 396
           S    E+ ++TL V+V
Sbjct: 831 SVSLPEVQRRTLDVAV 846



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 18/80 (22%), Positives = 39/80 (48%)

Query: 77  GDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSADAYVKANLLPGASKASQ 136
           G +   + LG ++ T+   +  + L    H  + L   +   +D YV+  LLP   ++ +
Sbjct: 751 GTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGR 810

Query: 137 LRTHTVRGTRVPVWEETLTY 156
            +TH  + T  PV++++  +
Sbjct: 811 RKTHVSKKTLNPVFDQSFDF 830


>gi|193804862 synaptotagmin-like 4 [Homo sapiens]
          Length = 671

 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 47/128 (36%), Positives = 68/128 (53%), Gaps = 6/128 (4%)

Query: 322 GGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYS 381
           G L V +    +L    A G SD FV+ +L P   K SK KT V +KTLNP +N  F Y+
Sbjct: 526 GELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYN 585

Query: 382 GPR-EELAQKTLLVSVWDYDLGTADDFIGGVQL--GSHASGERLRHWLECLGHSDHRLEL 438
           G R E+L    L ++VWD +   ++DF+GGV+L  G+  S   +  W++  G     + L
Sbjct: 586 GVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTG---EEVSL 642

Query: 439 WHPLDSKP 446
           W  +   P
Sbjct: 643 WQKMRQYP 650



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 45/125 (36%), Positives = 66/125 (52%), Gaps = 3/125 (2%)

Query: 309 GHVLLSLCYSSQQGGLLVGVLRCAHLAPMD-ANGYSDPFVRLFLHPNAGKKSKFKTSVHR 367
           G +  SL Y  Q   L+V V  C  LA  D A   S+P+V+ +L P+  ++ K KTS+ R
Sbjct: 358 GRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKR 417

Query: 368 KTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIG--GVQLGSHASGERLRHW 425
            T+NP ++E   Y  P   LAQ+TL  SVW +     + F+G   +Q+ S    ++L H 
Sbjct: 418 DTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHC 477

Query: 426 LECLG 430
           L   G
Sbjct: 478 LPLHG 482



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 18/51 (35%), Positives = 31/51 (60%)

Query: 115 ASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAE 165
           A G++D++VK  LLP  +KAS+ +T  ++ T  P +  T  Y+G   +D +
Sbjct: 543 AGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQ 593



 Score = 36.6 bits (83), Expect = 0.048
 Identities = 24/82 (29%), Positives = 37/82 (45%), Gaps = 2/82 (2%)

Query: 77  GDSDDSTALGTLEFTLLFEADNSAL--HCTAHRAKGLKPLASGSADAYVKANLLPGASKA 134
           GD  +    G + F+L +E    +L  H            A   ++ YVK  LLP  S+ 
Sbjct: 349 GDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQ 408

Query: 135 SQLRTHTVRGTRVPVWEETLTY 156
            + +T   R T  P+++ETL Y
Sbjct: 409 GKRKTSIKRDTINPLYDETLRY 430


>gi|193804860 synaptotagmin-like 4 [Homo sapiens]
          Length = 671

 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 47/128 (36%), Positives = 68/128 (53%), Gaps = 6/128 (4%)

Query: 322 GGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYS 381
           G L V +    +L    A G SD FV+ +L P   K SK KT V +KTLNP +N  F Y+
Sbjct: 526 GELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYN 585

Query: 382 GPR-EELAQKTLLVSVWDYDLGTADDFIGGVQL--GSHASGERLRHWLECLGHSDHRLEL 438
           G R E+L    L ++VWD +   ++DF+GGV+L  G+  S   +  W++  G     + L
Sbjct: 586 GVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTG---EEVSL 642

Query: 439 WHPLDSKP 446
           W  +   P
Sbjct: 643 WQKMRQYP 650



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 45/125 (36%), Positives = 66/125 (52%), Gaps = 3/125 (2%)

Query: 309 GHVLLSLCYSSQQGGLLVGVLRCAHLAPMD-ANGYSDPFVRLFLHPNAGKKSKFKTSVHR 367
           G +  SL Y  Q   L+V V  C  LA  D A   S+P+V+ +L P+  ++ K KTS+ R
Sbjct: 358 GRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKR 417

Query: 368 KTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIG--GVQLGSHASGERLRHW 425
            T+NP ++E   Y  P   LAQ+TL  SVW +     + F+G   +Q+ S    ++L H 
Sbjct: 418 DTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHC 477

Query: 426 LECLG 430
           L   G
Sbjct: 478 LPLHG 482



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 18/51 (35%), Positives = 31/51 (60%)

Query: 115 ASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAE 165
           A G++D++VK  LLP  +KAS+ +T  ++ T  P +  T  Y+G   +D +
Sbjct: 543 AGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQ 593



 Score = 36.6 bits (83), Expect = 0.048
 Identities = 24/82 (29%), Positives = 37/82 (45%), Gaps = 2/82 (2%)

Query: 77  GDSDDSTALGTLEFTLLFEADNSAL--HCTAHRAKGLKPLASGSADAYVKANLLPGASKA 134
           GD  +    G + F+L +E    +L  H            A   ++ YVK  LLP  S+ 
Sbjct: 349 GDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQ 408

Query: 135 SQLRTHTVRGTRVPVWEETLTY 156
            + +T   R T  P+++ETL Y
Sbjct: 409 GKRKTSIKRDTINPLYDETLRY 430


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 49/134 (36%), Positives = 67/134 (50%), Gaps = 19/134 (14%)

Query: 282 VPSAPDPKHNSARSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANG 341
           VPS     H   R    ++ EVA E+                L V V    +L PMD NG
Sbjct: 147 VPSLCGMDHTEKRGRIYLKAEVADEK----------------LHVTVRDAKNLIPMDPNG 190

Query: 342 YSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEF-FYSGPREELAQKTLLVSVWDYD 400
            SDP+V+L L P+   +SK KT   R TLNP++NE F F   P ++   + L V +WD+D
Sbjct: 191 LSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDK--DRRLSVEIWDWD 248

Query: 401 LGTADDFIGGVQLG 414
             T +DF+G +  G
Sbjct: 249 RTTRNDFMGSLSFG 262



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 24/63 (38%), Positives = 34/63 (53%), Gaps = 1/63 (1%)

Query: 95  EADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEET 153
           E  +  LH T   AK L P+  +G +D YVK  L+P     S+ +T T+R T  P W E+
Sbjct: 167 EVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNES 226

Query: 154 LTY 156
            T+
Sbjct: 227 FTF 229


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score = 72.4 bits (176), Expect = 8e-13
 Identities = 41/111 (36%), Positives = 62/111 (55%), Gaps = 2/111 (1%)

Query: 324 LLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGP 383
           L+V V    +L PMD NG SDP+V+L L P+   +SK KT   + +LNPE+NE F +   
Sbjct: 173 LIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQ-L 231

Query: 384 REELAQKTLLVSVWDYDLGTADDFIGGVQLG-SHASGERLRHWLECLGHSD 433
           +E    + L V +WD+DL + +DF+G +  G S      +  W + L   +
Sbjct: 232 KESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEE 282



 Score = 37.7 bits (86), Expect = 0.021
 Identities = 20/61 (32%), Positives = 30/61 (49%), Gaps = 1/61 (1%)

Query: 97  DNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLT 155
           D   L      AK L P+  +G +D YVK  L+P     S+ +T T++ +  P W ET  
Sbjct: 169 DRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFR 228

Query: 156 Y 156
           +
Sbjct: 229 F 229


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,262,932
Number of Sequences: 37866
Number of extensions: 1079097
Number of successful extensions: 4025
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 88
Number of HSP's successfully gapped in prelim test: 91
Number of HSP's that attempted gapping in prelim test: 3540
Number of HSP's gapped (non-prelim): 464
length of query: 451
length of database: 18,247,518
effective HSP length: 106
effective length of query: 345
effective length of database: 14,233,722
effective search space: 4910634090
effective search space used: 4910634090
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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