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Search of human proteins with 111074524
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|111074524 Src homology 2 domain containing F [Homo sapiens]
(423 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|111074524 Src homology 2 domain containing F [Homo sapiens] 876 0.0
gi|106879210 Src homology 2 domain containing adaptor protein B ... 271 6e-73
gi|58219064 Src homology 2 domain containing E [Homo sapiens] 248 1e-65
gi|222537752 Src homology 2 domain containing transforming prote... 245 6e-65
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 68 1e-11
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 62 8e-10
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 62 8e-10
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 62 8e-10
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 62 8e-10
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 62 8e-10
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 59 8e-09
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 59 8e-09
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 58 1e-08
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 58 1e-08
gi|38787970 tensin like C1 domain containing phosphatase isoform... 58 2e-08
gi|38787957 tensin like C1 domain containing phosphatase isoform... 58 2e-08
gi|38787941 tensin like C1 domain containing phosphatase isoform... 58 2e-08
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 57 3e-08
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 57 3e-08
gi|157820785 SH2 domain containing 7 [Homo sapiens] 54 2e-07
gi|4503787 fyn-related kinase [Homo sapiens] 53 6e-07
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 52 8e-07
gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 52 1e-06
gi|222446609 rai-like protein [Homo sapiens] 52 1e-06
gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 52 1e-06
gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 52 1e-06
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 51 2e-06
gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 51 2e-06
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 50 3e-06
gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 50 5e-06
>gi|111074524 Src homology 2 domain containing F [Homo sapiens]
Length = 423
Score = 876 bits (2263), Expect = 0.0
Identities = 423/423 (100%), Positives = 423/423 (100%)
Query: 1 MQQEGGPVRSAPCRTGTLEGSRQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHR 60
MQQEGGPVRSAPCRTGTLEGSRQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHR
Sbjct: 1 MQQEGGPVRSAPCRTGTLEGSRQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHR 60
Query: 61 EPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEG 120
EPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEG
Sbjct: 61 EPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEG 120
Query: 121 SAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATPEGE 180
SAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATPEGE
Sbjct: 121 SAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATPEGE 180
Query: 181 GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS 240
GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS
Sbjct: 181 GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS 240
Query: 241 LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL 300
LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL
Sbjct: 241 LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL 300
Query: 301 SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLS 360
SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLS
Sbjct: 301 SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLS 360
Query: 361 LKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
LKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI
Sbjct: 361 LKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
Query: 421 RTL 423
RTL
Sbjct: 421 RTL 423
>gi|106879210 Src homology 2 domain containing adaptor protein B
[Homo sapiens]
Length = 509
Score = 271 bits (694), Expect = 6e-73
Identities = 174/406 (42%), Positives = 217/406 (53%), Gaps = 69/406 (16%)
Query: 22 RQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHREPISSSPQPVANGPKQKKKSN 81
R +P + SPK L + + PL CA S P A G K+
Sbjct: 169 RPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWS----PTACGGKKLLNKC 224
Query: 82 WRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPY 141
S +D++ I +DY+DPFD + + AG E+ GYMEPY
Sbjct: 225 AASAAEESGAGKKDKV-----TIADDYSDPFDAKNDLKSKAGKG-------ESAGYMEPY 272
Query: 142 EAQKMMAEIRGSKETATQP--LPLYDTPYEPEEDGATPEGEGAPWPR--ESRLPEDDERP 197
EAQ++M E + + +Q + LYDTPYEPE + E PR ES+LP+DD+RP
Sbjct: 273 EAQRIMTEFQRQESVRSQHKGIQLYDTPYEPEGQSVDSDSESTVSPRLRESKLPQDDDRP 332
Query: 198 PEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPE 257
+EY D PW + +
Sbjct: 333 ADEY-----------------------DQPWE----------------------WNRVTI 347
Query: 258 PSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALP 317
P+L +AQF G EK SP R R G K K S E LGE DPA+P
Sbjct: 348 PAL---AAQFNGNEKRQSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAVP 404
Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
LE Q+WYHGAISR DAENLLRLCKE SYLVRNS+TSK+D+SLSL+S+QGFMHMKL++TKE
Sbjct: 405 LEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKE 464
Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
KYVLGQNSPPF SVPE++H+Y +RKLPIKGAEH+SLLYPVA+RTL
Sbjct: 465 -KYVLGQNSPPFDSVPEVIHYYTTRKLPIKGAEHLSLLYPVAVRTL 509
>gi|58219064 Src homology 2 domain containing E [Homo sapiens]
Length = 495
Score = 248 bits (632), Expect = 1e-65
Identities = 158/402 (39%), Positives = 208/402 (51%), Gaps = 108/402 (26%)
Query: 52 PLNSHCAHREPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADP 111
P +S + S+S P + GP+ K +II+ ++ + ILEDYADP
Sbjct: 162 PSSSSSSSSSSSSASSSPSSLGPELDKG---------KIIKQQETV-----IILEDYADP 207
Query: 112 FDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIR-------------------- 151
+D + T +G A E+V ENDGYMEPY+AQ+M+ EIR
Sbjct: 208 YDAKRT-KGQRDA----ERVGENDGYMEPYDAQQMITEIRRRGSKDPLVKALQLLDSPCE 262
Query: 152 ---------------GSKETATQPLPLYDTPYEPEEDGATPEGEGAPWPRESRLPEDDER 196
SK+ +P LYDTPYEP E G P EG P +SRLPE+DER
Sbjct: 263 PADGGLKSETLAKRRSSKDLLGKPPQLYDTPYEPAEGG--PRAEGKARPPDSRLPENDER 320
Query: 197 PPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLP 256
P EY+QPWEWKKE+I +A +V
Sbjct: 321 PAAEYEQPWEWKKEQIVRALSV-------------------------------------- 342
Query: 257 EPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPAL 316
QFEG E+ REE R R + K KP + S GE DP L
Sbjct: 343 ---------QFEGAERPSF---REETVRQHHRQKSWTQKILKPALSDHSE--GEKVDPGL 388
Query: 317 PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
PLE Q WYHGAISR +AE+ L+ CKEA YLVRNSE+ + +S++LK+SQG +H+ +++TK
Sbjct: 389 PLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTK 448
Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
++KY L Q S F S+PE+VH+Y++ KLP KGAEHM+LLYPV
Sbjct: 449 DNKYTLNQTSAVFDSIPEVVHYYSNEKLPFKGAEHMTLLYPV 490
>gi|222537752 Src homology 2 domain containing transforming protein
D [Homo sapiens]
Length = 340
Score = 245 bits (625), Expect = 6e-65
Identities = 149/367 (40%), Positives = 199/367 (54%), Gaps = 93/367 (25%)
Query: 67 PQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAIL----------EDYADPFDVQE 116
P P G + + + R+I++ R A+L +Y DPFD Q
Sbjct: 55 PDPAGPGDSKNPGDAKYGSPKHRLIKVEAADMARAKALLGGPGEELEADTEYLDPFDAQ- 113
Query: 117 TGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGAT 176
P P +DGYMEPY+AQ +M+E+ G + + LYDTPYE E+D T
Sbjct: 114 -----------PHPAPPDDGYMEPYDAQWVMSELPG------RGVQLYDTPYE-EQDPET 155
Query: 177 PEGE-GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQL 235
+G PR+SR+P++DERP +EYDQPWEWKK+ IS+AFAV
Sbjct: 156 ADGPPSGQKPRQSRMPQEDERPADEYDQPWEWKKDHISRAFAV----------------- 198
Query: 236 DSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPK 295
QF+ PE +PG ++ R PP P+
Sbjct: 199 ------------------------------QFDSPEWE-RTPGSAKELRRPP------PR 221
Query: 296 SAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKN 355
S +P E DPALPLE Q W+HG ++R DAE+LL LCKE SYLVR SET+
Sbjct: 222 SPQP---------AERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQ 272
Query: 356 DFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL 415
D SLSL+SSQGF+H+K +RT+E++ VLGQ+S PF SVPE+V HY+SR LP++GAEH++LL
Sbjct: 273 DCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALL 332
Query: 416 YPVAIRT 422
YPV +T
Sbjct: 333 YPVVTQT 339
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 68.2 bits (165), Expect = 1e-11
Identities = 46/120 (38%), Positives = 67/120 (55%), Gaps = 8/120 (6%)
Query: 302 MEPSSPLGEWTDPALP--LENQVWYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFS 358
+EPS P ++ P+L WY+G ++R AE L E +L+R+SE+S NDFS
Sbjct: 259 LEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFS 318
Query: 359 LSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
+SLK+ H K+ + KE Y +GQ FS++ E+V HY +K PI +E LY V
Sbjct: 319 VSLKAQGKNKHFKV-QLKETVYCIGQRK--FSTMEELVEHY--KKAPIFTSEQGEKLYLV 373
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 62.4 bits (150), Expect = 8e-10
Identities = 34/89 (38%), Positives = 52/89 (58%), Gaps = 3/89 (3%)
Query: 314 PALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
P LE WYHG +SR+ AE LL S+LVR SE+S S+SL+ H +++
Sbjct: 149 PVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRIN 208
Query: 374 RTKEHK-YVLGQNSPPFSSVPEIVHHYAS 401
T + K YV ++ FS++ E+VHH+++
Sbjct: 209 TTADGKVYVTAESR--FSTLAELVHHHST 235
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 62.4 bits (150), Expect = 8e-10
Identities = 34/89 (38%), Positives = 52/89 (58%), Gaps = 3/89 (3%)
Query: 314 PALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
P LE WYHG +SR+ AE LL S+LVR SE+S S+SL+ H +++
Sbjct: 164 PVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRIN 223
Query: 374 RTKEHK-YVLGQNSPPFSSVPEIVHHYAS 401
T + K YV ++ FS++ E+VHH+++
Sbjct: 224 TTADGKVYVTAESR--FSTLAELVHHHST 250
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 62.4 bits (150), Expect = 8e-10
Identities = 34/89 (38%), Positives = 52/89 (58%), Gaps = 3/89 (3%)
Query: 314 PALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
P LE WYHG +SR+ AE LL S+LVR SE+S S+SL+ H +++
Sbjct: 143 PVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRIN 202
Query: 374 RTKEHK-YVLGQNSPPFSSVPEIVHHYAS 401
T + K YV ++ FS++ E+VHH+++
Sbjct: 203 TTADGKVYVTAESR--FSTLAELVHHHST 229
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 62.4 bits (150), Expect = 8e-10
Identities = 34/89 (38%), Positives = 52/89 (58%), Gaps = 3/89 (3%)
Query: 314 PALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
P LE WYHG +SR+ AE LL S+LVR SE+S S+SL+ H +++
Sbjct: 149 PVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRIN 208
Query: 374 RTKEHK-YVLGQNSPPFSSVPEIVHHYAS 401
T + K YV ++ FS++ E+VHH+++
Sbjct: 209 TTADGKVYVTAESR--FSTLAELVHHHST 235
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 62.4 bits (150), Expect = 8e-10
Identities = 34/89 (38%), Positives = 52/89 (58%), Gaps = 3/89 (3%)
Query: 314 PALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
P LE WYHG +SR+ AE LL S+LVR SE+S S+SL+ H +++
Sbjct: 128 PVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRIN 187
Query: 374 RTKEHK-YVLGQNSPPFSSVPEIVHHYAS 401
T + K YV ++ FS++ E+VHH+++
Sbjct: 188 TTADGKVYVTAESR--FSTLAELVHHHST 214
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 58.9 bits (141), Expect = 8e-09
Identities = 38/97 (39%), Positives = 58/97 (59%), Gaps = 6/97 (6%)
Query: 323 WYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
WY+G ++R AE L E +L+R+SE+S +DFS+SLK+S H K+ + ++ Y
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKV-QLVDNVYC 343
Query: 382 LGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
+GQ F ++ E+V HY +K PI +EH LY V
Sbjct: 344 IGQRR--FHTMDELVEHY--KKAPIFTSEHGEKLYLV 376
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 58.9 bits (141), Expect = 8e-09
Identities = 38/97 (39%), Positives = 58/97 (59%), Gaps = 6/97 (6%)
Query: 323 WYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
WY+G ++R AE L E +L+R+SE+S +DFS+SLK+S H K+ + ++ Y
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKV-QLVDNVYC 343
Query: 382 LGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
+GQ F ++ E+V HY +K PI +EH LY V
Sbjct: 344 IGQRR--FHTMDELVEHY--KKAPIFTSEHGEKLYLV 376
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 58.2 bits (139), Expect = 1e-08
Identities = 31/88 (35%), Positives = 48/88 (54%), Gaps = 1/88 (1%)
Query: 314 PALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
P LE WYHG +SR AE LL S+LVR SE+S S+SL+ H +++
Sbjct: 118 PVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRIN 177
Query: 374 RTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
+ K + S F+++ E+VHH+++
Sbjct: 178 TASDGKLYVSSES-RFNTLAELVHHHST 204
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 58.2 bits (139), Expect = 1e-08
Identities = 31/88 (35%), Positives = 48/88 (54%), Gaps = 1/88 (1%)
Query: 314 PALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
P LE WYHG +SR AE LL S+LVR SE+S S+SL+ H +++
Sbjct: 137 PVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRIN 196
Query: 374 RTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
+ K + S F+++ E+VHH+++
Sbjct: 197 TASDGKLYVSSES-RFNTLAELVHHHST 223
>gi|38787970 tensin like C1 domain containing phosphatase isoform 3
[Homo sapiens]
Length = 1285
Score = 57.8 bits (138), Expect = 2e-08
Identities = 91/373 (24%), Positives = 131/373 (35%), Gaps = 77/373 (20%)
Query: 20 GSRQGSPGHRKRASPKGSLSSAQPHSWMLTP--------SPLNSHCAHREPISSSPQPV- 70
G R PGH A P S S +P SW P SP ++ C+ +S P+
Sbjct: 730 GDRYPLPGHLASAGPLASAESLEPVSWREGPSGHSTLPRSPRDAPCSASSELSGPSTPLH 789
Query: 71 ANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEK 130
+ P Q K+S R TR RL P + P AG APE
Sbjct: 790 TSSPVQGKESTRRQDTRSPTSAPTQRLSP------GEALPPV-------SQAGTGKAPE- 835
Query: 131 VPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATPEGEGAPWPRESRL 190
+P G P PL +P P P + WP+E R
Sbjct: 836 LPSGSG-----------------------PEPLAPSPVSP----TFPPSSPSDWPQE-RS 867
Query: 191 P---EDDERP--------PEEYDQPWEWKKERISKAFAVDI-KVIKDLPW---PPPVGQL 235
P D P P PW+ + + V +PW P Q
Sbjct: 868 PGGHSDGASPRSPVPTTLPGLRHAPWQGPRGPPDSPDGSPLTPVPSQMPWLVASPEPPQS 927
Query: 236 DSSPSLP-DGDRDISGPAS-PLPEPSLEDSSAQFEGP----EKSCLSPGREEKGRLPPRL 289
+P+ P D +G + PLPE Q GP + S + G P L
Sbjct: 928 SPTPAFPLAASYDTNGLSQPPLPEKRHLPGPGQQPGPWGPEQASSPARGISHHVTFAPLL 987
Query: 290 SAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRN 349
S P++ +P + E S + D ++ WY +SR A LL+ ++L+R+
Sbjct: 988 SDNVPQTPEPPTQESQSNVKFVQD-----TSKFWYKPHLSRDQAIALLKDKDPGAFLIRD 1042
Query: 350 SETSKNDFSLSLK 362
S + + + L+LK
Sbjct: 1043 SHSFQGAYGLALK 1055
>gi|38787957 tensin like C1 domain containing phosphatase isoform 2
[Homo sapiens]
Length = 1409
Score = 57.8 bits (138), Expect = 2e-08
Identities = 91/373 (24%), Positives = 131/373 (35%), Gaps = 77/373 (20%)
Query: 20 GSRQGSPGHRKRASPKGSLSSAQPHSWMLTP--------SPLNSHCAHREPISSSPQPV- 70
G R PGH A P S S +P SW P SP ++ C+ +S P+
Sbjct: 854 GDRYPLPGHLASAGPLASAESLEPVSWREGPSGHSTLPRSPRDAPCSASSELSGPSTPLH 913
Query: 71 ANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEK 130
+ P Q K+S R TR RL P + P AG APE
Sbjct: 914 TSSPVQGKESTRRQDTRSPTSAPTQRLSP------GEALPPV-------SQAGTGKAPE- 959
Query: 131 VPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATPEGEGAPWPRESRL 190
+P G P PL +P P P + WP+E R
Sbjct: 960 LPSGSG-----------------------PEPLAPSPVSP----TFPPSSPSDWPQE-RS 991
Query: 191 P---EDDERP--------PEEYDQPWEWKKERISKAFAVDI-KVIKDLPW---PPPVGQL 235
P D P P PW+ + + V +PW P Q
Sbjct: 992 PGGHSDGASPRSPVPTTLPGLRHAPWQGPRGPPDSPDGSPLTPVPSQMPWLVASPEPPQS 1051
Query: 236 DSSPSLP-DGDRDISGPAS-PLPEPSLEDSSAQFEGP----EKSCLSPGREEKGRLPPRL 289
+P+ P D +G + PLPE Q GP + S + G P L
Sbjct: 1052 SPTPAFPLAASYDTNGLSQPPLPEKRHLPGPGQQPGPWGPEQASSPARGISHHVTFAPLL 1111
Query: 290 SAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRN 349
S P++ +P + E S + D ++ WY +SR A LL+ ++L+R+
Sbjct: 1112 SDNVPQTPEPPTQESQSNVKFVQD-----TSKFWYKPHLSRDQAIALLKDKDPGAFLIRD 1166
Query: 350 SETSKNDFSLSLK 362
S + + + L+LK
Sbjct: 1167 SHSFQGAYGLALK 1179
>gi|38787941 tensin like C1 domain containing phosphatase isoform 1
[Homo sapiens]
Length = 1419
Score = 57.8 bits (138), Expect = 2e-08
Identities = 91/373 (24%), Positives = 131/373 (35%), Gaps = 77/373 (20%)
Query: 20 GSRQGSPGHRKRASPKGSLSSAQPHSWMLTP--------SPLNSHCAHREPISSSPQPV- 70
G R PGH A P S S +P SW P SP ++ C+ +S P+
Sbjct: 864 GDRYPLPGHLASAGPLASAESLEPVSWREGPSGHSTLPRSPRDAPCSASSELSGPSTPLH 923
Query: 71 ANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEK 130
+ P Q K+S R TR RL P + P AG APE
Sbjct: 924 TSSPVQGKESTRRQDTRSPTSAPTQRLSP------GEALPPV-------SQAGTGKAPE- 969
Query: 131 VPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATPEGEGAPWPRESRL 190
+P G P PL +P P P + WP+E R
Sbjct: 970 LPSGSG-----------------------PEPLAPSPVSP----TFPPSSPSDWPQE-RS 1001
Query: 191 P---EDDERP--------PEEYDQPWEWKKERISKAFAVDI-KVIKDLPW---PPPVGQL 235
P D P P PW+ + + V +PW P Q
Sbjct: 1002 PGGHSDGASPRSPVPTTLPGLRHAPWQGPRGPPDSPDGSPLTPVPSQMPWLVASPEPPQS 1061
Query: 236 DSSPSLP-DGDRDISGPAS-PLPEPSLEDSSAQFEGP----EKSCLSPGREEKGRLPPRL 289
+P+ P D +G + PLPE Q GP + S + G P L
Sbjct: 1062 SPTPAFPLAASYDTNGLSQPPLPEKRHLPGPGQQPGPWGPEQASSPARGISHHVTFAPLL 1121
Query: 290 SAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRN 349
S P++ +P + E S + D ++ WY +SR A LL+ ++L+R+
Sbjct: 1122 SDNVPQTPEPPTQESQSNVKFVQD-----TSKFWYKPHLSRDQAIALLKDKDPGAFLIRD 1176
Query: 350 SETSKNDFSLSLK 362
S + + + L+LK
Sbjct: 1177 SHSFQGAYGLALK 1189
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 57.0 bits (136), Expect = 3e-08
Identities = 26/89 (29%), Positives = 53/89 (59%), Gaps = 3/89 (3%)
Query: 317 PLENQVWYHGAISRTDAENLLRLCKEA-SYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
P E ++W+HG IS+ +A NLL + S+LVR S+ + D+SL ++++ K+ T
Sbjct: 345 PHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPT 404
Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
+++++G ++S+ +I+ HY ++
Sbjct: 405 PNNQFMMGGRY--YNSIGDIIDHYRKEQI 431
Score = 53.1 bits (126), Expect = 5e-07
Identities = 38/105 (36%), Positives = 54/105 (51%), Gaps = 9/105 (8%)
Query: 317 PLENQVWYHGAISRTDAENLLRLC-KEASYLVRNSETSKNDFSLSLKSSQGFM-HMKLSR 374
P NQ WYHG + RT AE LR K SYL+R S+ F LS S + H ++
Sbjct: 176 PPTNQ-WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIA 234
Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
Y+ G+ FSS+ +++ +Y+ +KG + LLYPVA
Sbjct: 235 MCGDYYIGGRR---FSSLSDLIGYYSHVSCLLKGEK---LLYPVA 273
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 57.0 bits (136), Expect = 3e-08
Identities = 26/89 (29%), Positives = 53/89 (59%), Gaps = 3/89 (3%)
Query: 317 PLENQVWYHGAISRTDAENLLRLCKEA-SYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
P E ++W+HG IS+ +A NLL + S+LVR S+ + D+SL ++++ K+ T
Sbjct: 168 PHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPT 227
Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
+++++G ++S+ +I+ HY ++
Sbjct: 228 PNNQFMMGGRY--YNSIGDIIDHYRKEQI 254
Score = 52.4 bits (124), Expect = 8e-07
Identities = 35/99 (35%), Positives = 51/99 (51%), Gaps = 8/99 (8%)
Query: 323 WYHGAISRTDAENLLRLC-KEASYLVRNSETSKNDFSLSLKSSQGFM-HMKLSRTKEHKY 380
WYHG + RT AE LR K SYL+R S+ F LS S + H ++ Y
Sbjct: 4 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 63
Query: 381 VLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
+ G+ FSS+ +++ +Y+ +KG + LLYPVA
Sbjct: 64 IGGRR---FSSLSDLIGYYSHVSCLLKGEK---LLYPVA 96
>gi|157820785 SH2 domain containing 7 [Homo sapiens]
Length = 451
Score = 54.3 bits (129), Expect = 2e-07
Identities = 38/130 (29%), Positives = 65/130 (50%), Gaps = 6/130 (4%)
Query: 275 LSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAE 334
LS GR+ +G + A + A ME +P + ALP W+HG I+R E
Sbjct: 8 LSLGRDPEGAGDSQALAELQELALKWFMETQAPF-ILQNGALP----PWFHGFITRKQTE 62
Query: 335 NLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPE 394
LLR S+L+R S+ + + LS + S H +++ + +Y++ ++ S++ E
Sbjct: 63 QLLRDKALGSFLIRLSDRATG-YILSYRGSDRCRHFVINQLRNRRYIISGDTQSHSTLAE 121
Query: 395 IVHHYASRKL 404
+VHHY +L
Sbjct: 122 LVHHYQEAQL 131
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 52.8 bits (125), Expect = 6e-07
Identities = 31/84 (36%), Positives = 46/84 (54%), Gaps = 3/84 (3%)
Query: 318 LENQVWYHGAISRTDAENLLRLC--KEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
L+ + W+ GAI R+DAE L K S+L+R SE+ K +FSLS+ H ++ R
Sbjct: 111 LQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRL 170
Query: 376 KEHKYVLGQNSPPFSSVPEIVHHY 399
E + L + FS++ E V HY
Sbjct: 171 DEGGFFLTRRR-IFSTLNEFVSHY 193
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 52.4 bits (124), Expect = 8e-07
Identities = 32/102 (31%), Positives = 50/102 (49%), Gaps = 5/102 (4%)
Query: 317 PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
PL Q WYHGAI R +A+ LL+ K+ +LVR S ++ LS+ S H +
Sbjct: 454 PLAEQDWYHGAIPRIEAQELLK--KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVD 511
Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
G FS++P+++ H+ + K I + LL P+
Sbjct: 512 NMYRFEGTG---FSNIPQLIDHHYTTKQVITKKSGVVLLNPI 550
>gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 2 [Homo sapiens]
Length = 454
Score = 52.0 bits (123), Expect = 1e-06
Identities = 37/130 (28%), Positives = 69/130 (53%), Gaps = 6/130 (4%)
Query: 293 NPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSET 352
+P + P +P++ + + L++ WY G ISR + LR + ++LVR++ T
Sbjct: 33 DPPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDAST 92
Query: 353 SKN-DFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSP-PFSSVPEIVHHYASRKLPIKGAE 410
+ D++L+L+ +K+ ++ KY G + P FSSV E+++HY + L +
Sbjct: 93 KMHGDYTLTLRKGGNNKLIKIFH-RDGKY--GFSDPLTFSSVVELINHYRNESLAQYNPK 149
Query: 411 -HMSLLYPVA 419
+ LLYPV+
Sbjct: 150 LDVKLLYPVS 159
Score = 37.7 bits (86), Expect = 0.020
Identities = 28/101 (27%), Positives = 52/101 (51%), Gaps = 3/101 (2%)
Query: 319 ENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH 378
+ + W G+ +R AENLLR ++ ++LVR S + + ++ S+ H +++T
Sbjct: 350 DEKTWNVGSSNRNKAENLLRGKRDGTFLVRES-SKQGCYACSVVVDGEVKHCVINKTAT- 407
Query: 379 KYVLGQNSPPFSSVPEIVHHYASRKL-PIKGAEHMSLLYPV 418
Y + +SS+ E+V HY L + +++L YPV
Sbjct: 408 GYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 448
>gi|222446609 rai-like protein [Homo sapiens]
Length = 630
Score = 51.6 bits (122), Expect = 1e-06
Identities = 46/152 (30%), Positives = 70/152 (46%), Gaps = 34/152 (22%)
Query: 290 SAGNPKSAKPL-----------SMEPSSPLGEWTDPALP-LENQVW----YHGAISRTDA 333
SAGN +SA+PL +++P + + +LP ++ Q+W YHG +SR A
Sbjct: 477 SAGNQRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAA 536
Query: 334 ENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL------SRTKEHKYVLGQNSP 387
E+L L K+ +LVR S TS + LS H+ L RTK+H
Sbjct: 537 ESL--LVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDH--------- 585
Query: 388 PFSSVPEIVHHYASRKLP-IKGAEHMSLLYPV 418
F +V ++ ++ LP I +SL PV
Sbjct: 586 VFDNVGHLIRYHMDNSLPIISSGSEVSLKQPV 617
>gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 51.6 bits (122), Expect = 1e-06
Identities = 41/137 (29%), Positives = 73/137 (53%), Gaps = 12/137 (8%)
Query: 286 PPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASY 345
PP L PK KP++ S+ D ++ L++ WY G ISR + + LR + ++
Sbjct: 34 PPALP---PKPPKPMT---SAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTF 87
Query: 346 LVRNSETS-KNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSP-PFSSVPEIVHHYASRK 403
LVR++ T + D++L+L+ +K+ ++ KY G + P F+SV E+++HY
Sbjct: 88 LVRDASTKMQGDYTLTLRKGGNNKLIKIYH-RDGKY--GFSDPLTFNSVVELINHYHHES 144
Query: 404 LPIKGAE-HMSLLYPVA 419
L + + L+YPV+
Sbjct: 145 LAQYNPKLDVKLMYPVS 161
Score = 32.7 bits (73), Expect = 0.64
Identities = 29/108 (26%), Positives = 51/108 (47%), Gaps = 4/108 (3%)
Query: 313 DPALP-LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMK 371
D LP + + W+ I+R AE+LL + ++L+R S + K ++ S+ + H
Sbjct: 347 DENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRES-SKKGCYACSVVADGEVKHCV 405
Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL-PIKGAEHMSLLYPV 418
+ T Y + +SS+ E+V HY L + ++ L YPV
Sbjct: 406 IYST-ARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPV 452
>gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 51.6 bits (122), Expect = 1e-06
Identities = 41/137 (29%), Positives = 73/137 (53%), Gaps = 12/137 (8%)
Query: 286 PPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASY 345
PP L PK KP++ S+ D ++ L++ WY G ISR + + LR + ++
Sbjct: 34 PPALP---PKPPKPMT---SAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTF 87
Query: 346 LVRNSETS-KNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSP-PFSSVPEIVHHYASRK 403
LVR++ T + D++L+L+ +K+ ++ KY G + P F+SV E+++HY
Sbjct: 88 LVRDASTKMQGDYTLTLRKGGNNKLIKIYH-RDGKY--GFSDPLTFNSVVELINHYHHES 144
Query: 404 LPIKGAE-HMSLLYPVA 419
L + + L+YPV+
Sbjct: 145 LAQYNPKLDVKLMYPVS 161
Score = 32.7 bits (73), Expect = 0.64
Identities = 29/108 (26%), Positives = 51/108 (47%), Gaps = 4/108 (3%)
Query: 313 DPALP-LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMK 371
D LP + + W+ I+R AE+LL + ++L+R S + K ++ S+ + H
Sbjct: 347 DENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRES-SKKGCYACSVVADGEVKHCV 405
Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL-PIKGAEHMSLLYPV 418
+ T Y + +SS+ E+V HY L + ++ L YPV
Sbjct: 406 IYST-ARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPV 452
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 51.2 bits (121), Expect = 2e-06
Identities = 36/111 (32%), Positives = 64/111 (57%), Gaps = 11/111 (9%)
Query: 312 TDPAL---PLENQVWYHGAISRTDAEN-LLRLCKEASYLVRNSETSKNDFSLSLKSSQGF 367
TDP P E++ WY+ ++SR +AE+ L+R+ ++ ++L+R E S + ++++ ++
Sbjct: 632 TDPVPNPNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGS-DSYAITFRARGKV 690
Query: 368 MHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
H +++R H +VLG S F S+ E+V +Y L K M L YPV
Sbjct: 691 KHCRINRDGRH-FVLG-TSAYFESLVELVSYYEKHSLYRK----MRLRYPV 735
Score = 47.8 bits (112), Expect = 2e-05
Identities = 34/92 (36%), Positives = 47/92 (51%), Gaps = 11/92 (11%)
Query: 323 WYHGAIS-RTDAENLLR-LC-----KEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
W+H + RT AE LL+ C K+ ++LVR SET ND++LS S H ++ T
Sbjct: 532 WFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRST 591
Query: 376 KEH---KYVLGQNSPPFSSVPEIVHHYASRKL 404
E KY L N FSS+ ++ HY L
Sbjct: 592 MEGGTLKYYLTDNL-TFSSIYALIQHYRETHL 622
>gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 3 [Homo sapiens]
Length = 424
Score = 50.8 bits (120), Expect = 2e-06
Identities = 37/130 (28%), Positives = 69/130 (53%), Gaps = 6/130 (4%)
Query: 293 NPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSET 352
N ++ P +P++ + + L++ WY G ISR + LR + ++LVR++ T
Sbjct: 3 NLQTLPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDAST 62
Query: 353 SKN-DFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSP-PFSSVPEIVHHYASRKLPIKGAE 410
+ D++L+L+ +K+ ++ KY G + P FSSV E+++HY + L +
Sbjct: 63 KMHGDYTLTLRKGGNNKLIKIFH-RDGKY--GFSDPLTFSSVVELINHYRNESLAQYNPK 119
Query: 411 -HMSLLYPVA 419
+ LLYPV+
Sbjct: 120 LDVKLLYPVS 129
Score = 37.7 bits (86), Expect = 0.020
Identities = 28/101 (27%), Positives = 52/101 (51%), Gaps = 3/101 (2%)
Query: 319 ENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH 378
+ + W G+ +R AENLLR ++ ++LVR S + + ++ S+ H +++T
Sbjct: 320 DEKTWNVGSSNRNKAENLLRGKRDGTFLVRES-SKQGCYACSVVVDGEVKHCVINKTAT- 377
Query: 379 KYVLGQNSPPFSSVPEIVHHYASRKL-PIKGAEHMSLLYPV 418
Y + +SS+ E+V HY L + +++L YPV
Sbjct: 378 GYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 418
>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
Length = 330
Score = 50.4 bits (119), Expect = 3e-06
Identities = 25/82 (30%), Positives = 45/82 (54%), Gaps = 2/82 (2%)
Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
W+H +SR AENLL + +++R S++S DFS+S++ H K+ R + Y L
Sbjct: 58 WFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL 117
Query: 383 GQNSPPFSSVPEIVHHYASRKL 404
+ F S+ ++V +Y + +
Sbjct: 118 W--TEKFPSLNKLVDYYRTNSI 137
>gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 1 [Homo sapiens]
Length = 724
Score = 49.7 bits (117), Expect = 5e-06
Identities = 36/124 (29%), Positives = 66/124 (53%), Gaps = 6/124 (4%)
Query: 299 PLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKN-DF 357
P +P++ + + L++ WY G ISR + LR + ++LVR++ T + D+
Sbjct: 309 PKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDY 368
Query: 358 SLSLKSSQGFMHMKLSRTKEHKYVLGQNSP-PFSSVPEIVHHYASRKLPIKGAE-HMSLL 415
+L+L+ +K+ ++ KY G + P FSSV E+++HY + L + + LL
Sbjct: 369 TLTLRKGGNNKLIKIFH-RDGKY--GFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLL 425
Query: 416 YPVA 419
YPV+
Sbjct: 426 YPVS 429
Score = 37.7 bits (86), Expect = 0.020
Identities = 28/101 (27%), Positives = 52/101 (51%), Gaps = 3/101 (2%)
Query: 319 ENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH 378
+ + W G+ +R AENLLR ++ ++LVR S + + ++ S+ H +++T
Sbjct: 620 DEKTWNVGSSNRNKAENLLRGKRDGTFLVRES-SKQGCYACSVVVDGEVKHCVINKTAT- 677
Query: 379 KYVLGQNSPPFSSVPEIVHHYASRKL-PIKGAEHMSLLYPV 418
Y + +SS+ E+V HY L + +++L YPV
Sbjct: 678 GYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 718
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.130 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,829,421
Number of Sequences: 37866
Number of extensions: 1364509
Number of successful extensions: 5867
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 97
Number of HSP's successfully gapped in prelim test: 395
Number of HSP's that attempted gapping in prelim test: 5202
Number of HSP's gapped (non-prelim): 999
length of query: 423
length of database: 18,247,518
effective HSP length: 105
effective length of query: 318
effective length of database: 14,271,588
effective search space: 4538364984
effective search space used: 4538364984
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.