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Search of human proteins with 166235136
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2
[Homo sapiens]
(910 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2 ... 1906 0.0
gi|166235138 seizure related 6 homolog (mouse)-like 2 isoform 3 ... 1658 0.0
gi|6912612 seizure related 6 homolog (mouse)-like 2 isoform 1 [H... 1649 0.0
gi|166235140 seizure related 6 homolog (mouse)-like 2 isoform 4 ... 1319 0.0
gi|148839346 seizure related 6 homolog isoform 2 [Homo sapiens] 795 0.0
gi|32261332 seizure related 6 homolog (mouse)-like precursor [Ho... 792 0.0
gi|148839280 seizure related 6 homolog isoform 1 [Homo sapiens] 779 0.0
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 232 1e-60
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 226 1e-58
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 224 4e-58
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 224 4e-58
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 212 1e-54
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 104 3e-22
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi... 104 3e-22
gi|148886654 polydom [Homo sapiens] 99 2e-20
gi|168693643 decay accelerating factor for complement isoform 2 ... 97 7e-20
gi|10835143 decay accelerating factor for complement isoform 1 p... 97 7e-20
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ... 94 8e-19
gi|157419154 selectin P precursor [Homo sapiens] 90 8e-18
gi|42544177 complement component (3d/Epstein Barr virus) recepto... 84 5e-16
gi|54792123 complement component (3d/Epstein Barr virus) recepto... 84 5e-16
gi|27502413 CD46 antigen, complement regulatory protein isoform ... 82 2e-15
gi|27502402 CD46 antigen, complement regulatory protein isoform ... 82 2e-15
gi|27502425 CD46 antigen, complement regulatory protein isoform ... 82 2e-15
gi|27502423 CD46 antigen, complement regulatory protein isoform ... 82 2e-15
gi|27502421 CD46 antigen, complement regulatory protein isoform ... 82 3e-15
gi|27502417 CD46 antigen, complement regulatory protein isoform ... 82 3e-15
gi|27502415 CD46 antigen, complement regulatory protein isoform ... 82 3e-15
gi|27502407 CD46 antigen, complement regulatory protein isoform ... 82 3e-15
gi|24432108 CD46 antigen, complement regulatory protein isoform ... 82 3e-15
>gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2
[Homo sapiens]
Length = 910
Score = 1906 bits (4937), Expect = 0.0
Identities = 910/910 (100%), Positives = 910/910 (100%)
Query: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 60
MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
Sbjct: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 60
Query: 61 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP 120
RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP
Sbjct: 61 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP 120
Query: 121 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEG 180
ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEG
Sbjct: 121 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEG 180
Query: 181 EGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGL 240
EGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGL
Sbjct: 181 EGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGL 240
Query: 241 APRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGD 300
APRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGD
Sbjct: 241 APRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGD 300
Query: 301 VSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGR 360
VSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGR
Sbjct: 301 VSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGR 360
Query: 361 IVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS 420
IVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS
Sbjct: 361 IVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS 420
Query: 421 DMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPE 480
DMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPE
Sbjct: 421 DMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPE 480
Query: 481 YRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLS 540
YRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLS
Sbjct: 481 YRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLS 540
Query: 541 PDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQ 600
PDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQ
Sbjct: 541 PDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQ 600
Query: 601 PRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHG 660
PRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHG
Sbjct: 601 PRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHG 660
Query: 661 DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD 720
DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD
Sbjct: 661 DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD 720
Query: 721 AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENG 780
AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENG
Sbjct: 721 AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENG 780
Query: 781 YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQL 840
YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQL
Sbjct: 781 YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQL 840
Query: 841 EGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYEA 900
EGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYEA
Sbjct: 841 EGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYEA 900
Query: 901 GDTREYEVSI 910
GDTREYEVSI
Sbjct: 901 GDTREYEVSI 910
>gi|166235138 seizure related 6 homolog (mouse)-like 2 isoform 3
[Homo sapiens]
Length = 840
Score = 1658 bits (4294), Expect = 0.0
Identities = 814/910 (89%), Positives = 818/910 (89%), Gaps = 70/910 (7%)
Query: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 60
MGTPRAQHPPPPQLLFLILLSCPWIQGL P E L E
Sbjct: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGL---------------PLKEEEILPE------- 38
Query: 61 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP 120
PGS+ PT+A+ + L L R E G
Sbjct: 39 ---------PGSET-PTVASEALAELLHGALLRRGPEMGY-------------------- 68
Query: 121 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEG 180
PGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEG
Sbjct: 69 ------------------LPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEG 110
Query: 181 EGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGL 240
EGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGL
Sbjct: 111 EGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGL 170
Query: 241 APRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGD 300
APRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGD
Sbjct: 171 APRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGD 230
Query: 301 VSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGR 360
VSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGR
Sbjct: 231 VSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGR 290
Query: 361 IVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS 420
IVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS
Sbjct: 291 IVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS 350
Query: 421 DMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPE 480
DMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPE
Sbjct: 351 DMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPE 410
Query: 481 YRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLS 540
YRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLS
Sbjct: 411 YRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLS 470
Query: 541 PDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQ 600
PDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQ
Sbjct: 471 PDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQ 530
Query: 601 PRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHG 660
PRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHG
Sbjct: 531 PRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHG 590
Query: 661 DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD 720
DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD
Sbjct: 591 DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD 650
Query: 721 AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENG 780
AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENG
Sbjct: 651 AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENG 710
Query: 781 YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQL 840
YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQL
Sbjct: 711 YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQL 770
Query: 841 EGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYEA 900
EGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYEA
Sbjct: 771 EGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYEA 830
Query: 901 GDTREYEVSI 910
GDTREYEVSI
Sbjct: 831 GDTREYEVSI 840
>gi|6912612 seizure related 6 homolog (mouse)-like 2 isoform 1 [Homo
sapiens]
Length = 853
Score = 1649 bits (4270), Expect = 0.0
Identities = 814/923 (88%), Positives = 818/923 (88%), Gaps = 83/923 (8%)
Query: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 60
MGTPRAQHPPPPQLLFLILLSCPWIQGL P E L E
Sbjct: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGL---------------PLKEEEILPE------- 38
Query: 61 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP 120
PGS+ PT+A+ + L L R E G
Sbjct: 39 ---------PGSET-PTVASEALAELLHGALLRRGPEMGY-------------------- 68
Query: 121 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEG 180
PGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEG
Sbjct: 69 ------------------LPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEG 110
Query: 181 EGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGL 240
EGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGL
Sbjct: 111 EGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGL 170
Query: 241 APRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGD 300
APRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGD
Sbjct: 171 APRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGD 230
Query: 301 VSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGR 360
VSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGR
Sbjct: 231 VSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGR 290
Query: 361 IVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS 420
IVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS
Sbjct: 291 IVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS 350
Query: 421 DMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPE 480
DMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPE
Sbjct: 351 DMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPE 410
Query: 481 YRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLS 540
YRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLS
Sbjct: 411 YRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLS 470
Query: 541 PDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQ 600
PDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQ
Sbjct: 471 PDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQ 530
Query: 601 PRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHG 660
PRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHG
Sbjct: 531 PRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHG 590
Query: 661 DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD 720
DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD
Sbjct: 591 DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD 650
Query: 721 AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENG 780
AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENG
Sbjct: 651 AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENG 710
Query: 781 YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK----------- 829
YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK
Sbjct: 711 YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDNRK 770
Query: 830 --VTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPI 887
VTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPI
Sbjct: 771 LEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPI 830
Query: 888 TVESDFSNPLYEAGDTREYEVSI 910
TVESDFSNPLYEAGDTREYEVSI
Sbjct: 831 TVESDFSNPLYEAGDTREYEVSI 853
>gi|166235140 seizure related 6 homolog (mouse)-like 2 isoform 4
[Homo sapiens]
Length = 809
Score = 1319 bits (3414), Expect = 0.0
Identities = 626/639 (97%), Positives = 626/639 (97%), Gaps = 13/639 (2%)
Query: 285 AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS 344
AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS
Sbjct: 171 AYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS 230
Query: 345 CMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 404
CMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL
Sbjct: 231 CMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 290
Query: 405 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC 464
MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC
Sbjct: 291 MVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC 350
Query: 465 FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 524
FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK
Sbjct: 351 FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 410
Query: 525 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFD 584
AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFD
Sbjct: 411 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFD 470
Query: 585 GDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC 644
GDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC
Sbjct: 471 GDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC 530
Query: 645 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMT 704
PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMT
Sbjct: 531 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMT 590
Query: 705 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 764
CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC
Sbjct: 591 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 650
Query: 765 ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ 824
ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ
Sbjct: 651 ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ 710
Query: 825 PPLCK-------------VTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQ 871
PPLCK VTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQ
Sbjct: 711 PPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQ 770
Query: 872 GKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI 910
GKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI
Sbjct: 771 GKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI 809
Score = 427 bits (1097), Expect = e-119
Identities = 320/859 (37%), Positives = 411/859 (47%), Gaps = 185/859 (21%)
Query: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 60
MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
Sbjct: 1 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL 60
Query: 61 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP 120
RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP
Sbjct: 61 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP 120
Query: 121 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSP---------- 170
ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSP
Sbjct: 121 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPP 180
Query: 171 ---------------------------------VLCNNNIS---EGE---------GYVE 185
++C N GE G +
Sbjct: 181 RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIH 240
Query: 186 SPDLGSPVSRTLG-----LLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGL 240
+ LG VS G L C + I G + + + ++L ++ + L++ GGSP L
Sbjct: 241 NATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP-L 299
Query: 241 AP-------------RLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYL 287
+P L++++ L + +P N LLL + ++A+
Sbjct: 300 SPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLL-------------SLRFEAFE 346
Query: 288 LSCGFPPRPAHGDVSVTD--LHPGGTATFHCDSGYQLQ---GEETLICLNGTRPSWNGET 342
F P AHG+V+ TD PG ATF C GY L+ + C++ T P WN
Sbjct: 347 EDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 406
Query: 343 PSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDND 402
P+C A CGG + + G ++SP+ + P C W + E +R+ L E +++ E D
Sbjct: 407 PACKAMCGGEL-SEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-GD 464
Query: 403 RLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSET-PANPLL---LSLRF-E 457
L + G P + V+ P R L+S L ++ + P NP L L F E
Sbjct: 465 MLTLFDGDGPSARVLAQL-RGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKE 523
Query: 458 AFEEDRC-FAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHW 516
D C P G T + + G + T+ C PGY L + + C + W
Sbjct: 524 VPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL---GSDILTC--QWDLSW 578
Query: 517 NDTEPACKAM--CG--GELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEIL 572
+ PAC+ + C GE++ +P C+ G
Sbjct: 579 SAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPG---------------Y 623
Query: 573 NVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFV 632
++ MLT + D + + ++ P L+++ P L G
Sbjct: 624 SLEGAAMLTCYSRDTGTPKWSDRV-------------PKCALKYE-------PCLNPG-- 661
Query: 633 LHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC--QWDL 690
VP N G++T G L + C G+EL+G +TC
Sbjct: 662 -----VPEN-----------GYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS 705
Query: 691 SWSAAPPACQ------------KIMTCADPGEIANGHRTASDAGFPV--------GSHVQ 730
W++ PP C+ ++ DP G A P+ G ++
Sbjct: 706 QWTSQPPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIY 765
Query: 731 YRCLPGYSLEGAAMLTCYS 749
Y L G SL G + YS
Sbjct: 766 YTKLQGKSLFGFSGSHSYS 784
>gi|148839346 seizure related 6 homolog isoform 2 [Homo sapiens]
Length = 993
Score = 795 bits (2053), Expect = 0.0
Identities = 428/952 (44%), Positives = 571/952 (59%), Gaps = 87/952 (9%)
Query: 37 PEPGSETPTVASEALAELLHGALLRRGPEMGYLPGSDR-DPTLATPPAGQTLAVPS-LPR 94
PE G T A L L H LL + G G + P L P PS LPR
Sbjct: 51 PERGVHFVTTAP-TLKLLNHHPLLEEFLQEGLEKGDEELRPALPFQPDPPAPFTPSPLPR 109
Query: 95 ATEPGTGPLTTAVTP-------NGVRGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGP- 146
+ P+ T+ TP GP +PE +P TAP PP P+ P LGP
Sbjct: 110 LANQDSRPVFTSPTPAMAAVPTQPQSKEGPWSPESESPMLRITAPLPPGPSMAVPTLGPG 169
Query: 147 ------------------------------------------------EGGEEETTTTII 158
G +EETTTT
Sbjct: 170 EIASTTPPSRAWTPTQEGPGDMGRPWVAEVVSQGAGIGIQGTITSSTASGDDEETTTTTT 229
Query: 159 TTTTVTTTVTSPVLCNNNISEGEGYVESP-DLGSPVSRTLGLLDCTYSIHVYPGYGIEIQ 217
TT TTV +P C+ N S EG ++SP DL SP +GL DC + I VYPGYG+EI+
Sbjct: 230 IITTTITTVQTPGPCSWNFSGPEGSLDSPTDLSSPTD--VGL-DCFFYISVYPGYGVEIK 286
Query: 218 VQTLNLSQEEELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGG 277
VQ ++L +E E + + G G P P LAN S L GQV+RSPT++ L FQS P G
Sbjct: 287 VQNISL-REGETVTVEGLGGPDPLP--LANQSFLLRGQVIRSPTHQAALRFQSLPPPAGP 343
Query: 278 G-FRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRP 336
G F HYQAYLLSC FP RPA+GDV+VT LHPGG+A FHC +GYQL+G L CLN T+P
Sbjct: 344 GTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQP 403
Query: 337 SWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS 396
W+ + P C+A+CGG I NAT GRIVSP G NLTC W++EA EG+RLHLHFE+VS
Sbjct: 404 FWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVS 463
Query: 397 LDEDNDRLMVRSGGSPLSPVIYDS-DMDDVPERGLISDAQSLYVELLSETPANPLLLSLR 455
L ED+DRL++R+G + +P +YDS +++ +P GL+S + +VEL +++ ++LR
Sbjct: 464 LAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALR 523
Query: 456 FEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH 515
+EAF++ C+ PF+ +GN +++ P Y G FSC PGY LE IECVDP +P
Sbjct: 524 YEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSI--IIECVDPHDPQ 581
Query: 516 WNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR 575
WN+TEPAC+A+C GE+++ AGVVLSP+WP+ Y GQDC+WGVHV+E+KRI+L + +L +
Sbjct: 582 WNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIG 641
Query: 576 EGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHF 635
GD+LT +DGD +ARVL Q GP+ +L +S D+T+QFQ+ PG G QGFV+HF
Sbjct: 642 PGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHF 701
Query: 636 KEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAA 695
EVPRNDTCPELP GW++ S +L+ GTV+TYQC PGY+++GS +L CQWDL+WS
Sbjct: 702 FEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSED 761
Query: 696 PPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTP 755
P+CQ++ +C DPG++ + R S FPVG+ VQY C G+ L G+++LTC+ R G+P
Sbjct: 762 LPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSP 821
Query: 756 KWSDRVPKCAL-KYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCV 814
KWSDR PKC L + +PC PENG ++ K + AG ++ F C G+ L G+ +I CV
Sbjct: 822 KWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCV 881
Query: 815 PGHPSQWTSQPPLCK--------------VTQTTDPSRQLEGGNLALAILLPLGLVIVLG 860
PGHPS W+ PP+C+ V + S L+ ++A AI LPL +++L
Sbjct: 882 PGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASSTLDAAHIAAAIFLPLVAMVLLV 941
Query: 861 SGVYIYYTKLQGKSLFGF--SGSHSYSPITVESDFSNPLYEAGDTREYEVSI 910
GVY Y+++LQGKS Y+ IT+ES F NP YE G+TREYEVSI
Sbjct: 942 GGVYFYFSRLQGKSSLQLPRPRPRPYNRITIESAFDNPTYETGETREYEVSI 993
>gi|32261332 seizure related 6 homolog (mouse)-like precursor [Homo
sapiens]
Length = 1024
Score = 792 bits (2046), Expect = 0.0
Identities = 398/841 (47%), Positives = 537/841 (63%), Gaps = 53/841 (6%)
Query: 115 AGPTAPELLTPPPGT-------TAPPPPSPASPGPPLGPEGGEE---------------- 151
A PT P L P T T P P P PGP + E +E
Sbjct: 192 AVPTTPAPLQISPFTSQPYVAHTLPQRPEPGEPGPDMAQEAPQEDTSPMALMDKGENELT 251
Query: 152 --------ETTTTIITTTTVTTTVTSPVLCNNNISEGEGYVESPDLGSPVSRTLGLLDCT 203
ETTT+ I TTTV TT +P LC+ + S EGY++S D P+ L+CT
Sbjct: 252 GSASEESQETTTSTIITTTVITTEQAPALCSVSFSNPEGYIDSSDY--PLLPLNNFLECT 309
Query: 204 YSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNR 263
Y++ VY GYG+E+QV+++NLS + ELL + G P L +LAN ++L EGQV+RSPTN
Sbjct: 310 YNVTVYTGYGVELQVKSVNLS-DGELLSIRGVDGPTLT--VLANQTLLVEGQVIRSPTNT 366
Query: 264 LLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQ 323
+ ++F++ + G F++HYQA++LSC FP RP GDV+V DLH GG A FHC GY+LQ
Sbjct: 367 ISVYFRTFQDDGLGTFQLHYQAFMLSCNFPRRPDSGDVTVMDLHSGGVAHFHCHLGYELQ 426
Query: 324 GEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAA 383
G + L C+N ++P W+ + P C A CGG +HNAT+GR++SP + C W IEA
Sbjct: 427 GAKMLTCINASKPHWSSQEPICSAPCGGAVHNATIGRVLSPSYPENTNGSQFCIWTIEAP 486
Query: 384 EGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS-DMDDVPERGLISDAQSLYVELL 442
EG++LHLHFER+ L D DR+ V SG + S ++YDS + VP GL+S+ ++ +E
Sbjct: 487 EGQKLHLHFERLLL-HDKDRMTVHSGQTNKSALLYDSLQTESVPFEGLLSEGNTIRIEFT 545
Query: 443 SETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGP 502
S+ ++RFEAFE+ C+ P++ +GN TT+DP Y G + F+C PG++LE
Sbjct: 546 SDQARAASTFNIRFEAFEKGHCYEPYIQNGNFTTSDPTYNIGTIVEFTCDPGHSLEQG-- 603
Query: 503 PNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEE 562
P IEC++ +P+WNDTEP C+AMCGGELS AGVVLSP+WP+ Y G+DC+W +HV EE
Sbjct: 604 PAIIECINVRDPYWNDTEPLCRAMCGGELSAVAGVVLSPNWPEPYVEGEDCIWKIHVGEE 663
Query: 563 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGP 622
KRI L ++ LN+ D+LT++DGD +L Q G ++L SS PDLT+QF + P
Sbjct: 664 KRIFLDIQFLNLSNSDILTIYDGDEVMPHILGQYLGNSGPQKLYSSTPDLTIQFHSDPAG 723
Query: 623 PNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSD 682
G GQGF++++ EV RND+C +LP + GW+T SH +L+RG +TYQC+PGY+++GSD
Sbjct: 724 LIFGKGQGFIMNYIEVSRNDSCSDLPEIQNGWKTTSHTELVRGARITYQCDPGYDIVGSD 783
Query: 683 ILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGA 742
LTCQWDLSWS+ PP C+KIM C DPGE+ + R SD VG+ +QY C PG+ LEG+
Sbjct: 784 TLTCQWDLSWSSDPPFCEKIMYCTDPGEVDHSTRLISDPVLLVGTTIQYTCNPGFVLEGS 843
Query: 743 AMLTCYSRDTGTPKWSDRVPKCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYE 801
++LTCYSR+TGTP W+ R+P C + C NPG+PENGYQ LYK Y GESL F CYE
Sbjct: 844 SLLTCYSRETGTPIWTSRLPHCVSEESLACDNPGLPENGYQILYKRLYLPGESLTFMCYE 903
Query: 802 GFELIGEVTITCVPGHPSQWTSQPPLCKVTQTT----------DPSRQLEGGNLALAILL 851
GFEL+GEVTI C+ G PS W P+CKV Q + LEGGN+ALAI +
Sbjct: 904 GFELMGEVTIRCILGQPSHWNGPLPVCKVNQDSFEHALEVAEAAAETSLEGGNMALAIFI 963
Query: 852 PLGLVIVLGSGVYIYYTKLQGKS--LFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVS 909
P+ ++ +L G YIY T+ + S SH YS ITVE++F NP+YE G+TREYEVS
Sbjct: 964 PVLIISLLLGGAYIYITRCRYYSNLRLPLMYSHPYSQITVETEFDNPIYETGETREYEVS 1023
Query: 910 I 910
I
Sbjct: 1024 I 1024
>gi|148839280 seizure related 6 homolog isoform 1 [Homo sapiens]
Length = 994
Score = 779 bits (2012), Expect = 0.0
Identities = 420/943 (44%), Positives = 562/943 (59%), Gaps = 87/943 (9%)
Query: 37 PEPGSETPTVASEALAELLHGALLRRGPEMGYLPGSDR-DPTLATPPAGQTLAVPS-LPR 94
PE G T A L L H LL + G G + P L P PS LPR
Sbjct: 51 PERGVHFVTTAP-TLKLLNHHPLLEEFLQEGLEKGDEELRPALPFQPDPPAPFTPSPLPR 109
Query: 95 ATEPGTGPLTTAVTP-------NGVRGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGP- 146
+ P+ T+ TP GP +PE +P TAP PP P+ P LGP
Sbjct: 110 LANQDSRPVFTSPTPAMAAVPTQPQSKEGPWSPESESPMLRITAPLPPGPSMAVPTLGPG 169
Query: 147 ------------------------------------------------EGGEEETTTTII 158
G +EETTTT
Sbjct: 170 EIASTTPPSRAWTPTQEGPGDMGRPWVAEVVSQGAGIGIQGTITSSTASGDDEETTTTTT 229
Query: 159 TTTTVTTTVTSPVLCNNNISEGEGYVESP-DLGSPVSRTLGLLDCTYSIHVYPGYGIEIQ 217
TT TTV +P C+ N S EG ++SP DL SP +GL DC + I VYPGYG+EI+
Sbjct: 230 IITTTITTVQTPGPCSWNFSGPEGSLDSPTDLSSPTD--VGL-DCFFYISVYPGYGVEIK 286
Query: 218 VQTLNLSQEEELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGG 277
VQ ++L +E E + + G G P P LAN S L GQV+RSPT++ L FQS P G
Sbjct: 287 VQNISL-REGETVTVEGLGGPDPLP--LANQSFLLRGQVIRSPTHQAALRFQSLPPPAGP 343
Query: 278 G-FRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRP 336
G F HYQAYLLSC FP RPA+GDV+VT LHPGG+A FHC +GYQL+G L CLN T+P
Sbjct: 344 GTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQP 403
Query: 337 SWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS 396
W+ + P C+A+CGG I NAT GRIVSP G NLTC W++EA EG+RLHLHFE+VS
Sbjct: 404 FWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVS 463
Query: 397 LDEDNDRLMVRSGGSPLSPVIYDS-DMDDVPERGLISDAQSLYVELLSETPANPLLLSLR 455
L ED+DRL++R+G + +P +YDS +++ +P GL+S + +VEL +++ ++LR
Sbjct: 464 LAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALR 523
Query: 456 FEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH 515
+EAF++ C+ PF+ +GN +++ P Y G FSC PGY LE IECVDP +P
Sbjct: 524 YEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSI--IIECVDPHDPQ 581
Query: 516 WNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR 575
WN+TEPAC+A+C GE+++ AGVVLSP+WP+ Y GQDC+WGVHV+E+KRI+L + +L +
Sbjct: 582 WNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIG 641
Query: 576 EGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHF 635
GD+LT +DGD +ARVL Q GP+ +L +S D+T+QFQ+ PG G QGFV+HF
Sbjct: 642 PGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHF 701
Query: 636 KEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAA 695
EVPRNDTCPELP GW++ S +L+ GTV+TYQC PGY+++GS +L CQWDL+WS
Sbjct: 702 FEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSED 761
Query: 696 PPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTP 755
P+CQ++ +C DPG++ + R S FPVG+ VQY C G+ L G+++LTC+ R G+P
Sbjct: 762 LPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSP 821
Query: 756 KWSDRVPKCAL-KYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCV 814
KWSDR PKC L + +PC PENG ++ K + AG ++ F C G+ L G+ +I CV
Sbjct: 822 KWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCV 881
Query: 815 PGHPSQWTSQPPLCK--------------VTQTTDPSRQLEGGNLALAILLPLGLVIVLG 860
PGHPS W+ PP+C+ V + S L+ ++A AI LPL +++L
Sbjct: 882 PGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASSTLDAAHIAAAIFLPLVAMVLLV 941
Query: 861 SGVYIYYTKLQGKSLFGF--SGSHSYSPITVESDFSNPLYEAG 901
GVY Y+++LQGKS Y+ IT+ES F NP YE G
Sbjct: 942 GGVYFYFSRLQGKSSLQLPRPRPRPYNRITIESAFDNPTYETG 984
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 232 bits (591), Expect = 1e-60
Identities = 158/518 (30%), Positives = 253/518 (48%), Gaps = 21/518 (4%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C N+++ +G + SP+ PV+ +C YSI PG GI+++ + LS+ + L V
Sbjct: 1098 CGNSVTGTQGTLLSPNF--PVNYNNNH-ECIYSIQTQPGKGIQLKARAFELSEGDVLKVY 1154
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAY-LLSCG 291
G + + ++S M+G L S ++ L L F + GF +H+ ++ L+ C
Sbjct: 1155 DGNNNSARLLGVFSHSEMMGV--TLNSTSSSLWLDFITDAENTSKGFELHFSSFELIKCE 1212
Query: 292 FPPRPAHGDVSVTDLH-PGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 350
P P G + H G + +F CD GY L+G E L+CL+G R +W+ P+C+A CG
Sbjct: 1213 DPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAECG 1272
Query: 351 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 410
GT+ G+++SP NL C W IEA G + LHF +E +D L + G
Sbjct: 1273 GTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIWDGP 1332
Query: 411 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 470
++ + +P + L S S+ ++ ++ + +++F C P +
Sbjct: 1333 VESGVLLKELSGPALP-KDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIP 1391
Query: 471 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVD-PTEPHWNDTEPACKAMCGG 529
N + + + G F C PGYAL+ I CV W + P C A CGG
Sbjct: 1392 Q-NGSRSGDSWEAGDSTVFQCDPGYALQGSA---EISCVKIENRFFWQPSPPTCIAPCGG 1447
Query: 530 ELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDGDGP 588
+L+ P+GV+LSP++P+ Y PG++C W V V + I L I N+ G D L ++DG
Sbjct: 1448 DLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDS 1507
Query: 589 SARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELP 648
+ ++ G Q R+ SS L L F++ N GFV+ + E PR ++C +
Sbjct: 1508 LSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSN----AGFVIDYTENPR-ESCFDPG 1562
Query: 649 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC 686
+ G R S DL G+ +TY C GYE+ G+ L+C
Sbjct: 1563 SIKNGTRVGS--DLKLGSSVTYYCHGGYEVEGTSTLSC 1598
Score = 202 bits (513), Expect = 2e-51
Identities = 187/722 (25%), Positives = 295/722 (40%), Gaps = 80/722 (11%)
Query: 179 EGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSP 238
E G V SP +P L +C ++I G I + + + ++L + G P
Sbjct: 1278 EVSGQVLSPGYPAPYEHNL---NCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIWDG--P 1332
Query: 239 GLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQ-AYLLSCGFPPRPA 297
+ LL S + L S N ++L F + GF I + + SC P P
Sbjct: 1333 VESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQ 1392
Query: 298 HGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGETPSCMASCGGTIHNA 356
+G S G + F CD GY LQG + C+ R W P+C+A CGG +
Sbjct: 1393 NGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGGDLTGP 1452
Query: 357 TLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPV 416
+ G I+SP P C W + + + L F +L+ D L + G LSP+
Sbjct: 1453 S-GVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDSLSPL 1511
Query: 417 IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTT 476
I +P R + S + SL++ S+ + + + + CF P N T
Sbjct: 1512 IGSFYGSQLPGR-IESSSNSLFLAFRSDASVSNAGFVIDYTENPRESCFDPGSIK-NGTR 1569
Query: 477 TDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAG 536
+ + G+ T+ C GY +E + I D +P WN+ P C A CGG+ G
Sbjct: 1570 VGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDG-KPVWNNPRPVCTAPCGGQYVGSDG 1628
Query: 537 VVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQL 596
VVLSP++PQ+Y+ GQ C++ V V ++ + Q + D++ + DG +R+L+ L
Sbjct: 1629 VVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSL 1688
Query: 597 RGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT--CPELPPPEWG 653
G L L++ + ++F A P +GF ++ VPR C +P P +G
Sbjct: 1689 SGSHTGESLPLATSNQVLIKFSAKGLAP----ARGFHFVYQAVPRTSATQCSSVPEPRYG 1744
Query: 654 WRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPACQKIMTCADPG 709
R S D G ++ ++C GY L GS + C W+ + P C ++ C G
Sbjct: 1745 KRLGS--DFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTC--VVPCG--G 1798
Query: 710 EIANGHRTASDAGF----------------PVGSHVQYRCLPGYS---------LEGA-- 742
+ T GF P G+ +Q + + + +GA
Sbjct: 1799 NLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADN 1858
Query: 743 --------------AMLTCYSRDTGTPKWSDRVPKCA---LKYE-----PCLNPGVPENG 780
A+L S +SD A L+Y+ C P VP NG
Sbjct: 1859 TVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNG 1918
Query: 781 YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQL 840
+T Y + + F C G+ L G I+C+PG +W PPLC + Q ++
Sbjct: 1919 VKT--GERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLC-IAQCGGTVEEM 1975
Query: 841 EG 842
EG
Sbjct: 1976 EG 1977
Score = 199 bits (506), Expect = 1e-50
Identities = 190/743 (25%), Positives = 304/743 (40%), Gaps = 81/743 (10%)
Query: 144 LGPEGGEEETTTTIITTTTV---TTTVTSPVLCNNNISEGEGYVESPDLGSPVSRTLGLL 200
LG +G E T T ++ +V + + C +++ G + SP G P L
Sbjct: 722 LGTQGSE--TITCVLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSP--GWP-GFYKDAL 776
Query: 201 DCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSP 260
C + I PGY I+I + L + G + AP L+ Q L S
Sbjct: 777 SCAWVIEAQPGYPIKITFDRFKTEVNYDTLEVRDGRTYS-AP-LIGVYHGTQVPQFLIST 834
Query: 261 TNRLLLHFQSPRVPRGGGFRIHYQAYLLS---CGFPPRPAHGDVSVTDLHPGGTATFHCD 317
+N L L F + + GF++ Y+ L C P P +G D + G TF CD
Sbjct: 835 SNYLYLLFSTDKSHSDIGFQLRYETITLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCD 894
Query: 318 SGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCR 377
SGY L E L C + W+ PSC A CGG I ++ G I+SP NL C
Sbjct: 895 SGYTLSDGEPLECEPNFQ--WSRALPSCEALCGGFIQGSS-GTILSPGFPDFYPNNLNCT 951
Query: 378 WVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPV--IYDSDMDDVPERGLISDAQ 435
W+IE + G+ + F L+ +D L++ GS P+ + S + GL +
Sbjct: 952 WIIETSHGKGVFFTFHTFHLESGHDYLLITENGSFTQPLRQLTGSRLPAPISAGLYGNFT 1011
Query: 436 SLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGY 495
+ V +S+ + ++ F ++ + C P + ++ ++ G TFSC PGY
Sbjct: 1012 A-QVRFISDFSMSYEGFNITFSEYDLEPCEEPEVPAYSIRK-GLQFGVGDTLTFSCFPGY 1069
Query: 496 ALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVW 555
LE I C+ W+ P C A CG ++ G +LSP++P +Y+ +C++
Sbjct: 1070 RLEGTA---RITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIY 1126
Query: 556 GVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRR-RLLSSGPDLTL 614
+ Q K I L+ + EGD+L ++DG+ SAR+L + L S+ L L
Sbjct: 1127 SIQTQPGKGIQLKARAFELSEGDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWL 1186
Query: 615 QFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEP 674
F +GF LHF C + P++G++ G G+ +++ C+P
Sbjct: 1187 DFITDA----ENTSKGFELHFSSF-ELIKCEDPGTPKFGYKVHDEGH-FAGSSVSFSCDP 1240
Query: 675 GYELLGSDILTC------QWDLSWSAAPPACQKIMTCADPGEIANGHRTA---------- 718
GY L GS+ L C WD C + G++ + A
Sbjct: 1241 GYSLRGSEELLCLSGERRTWDRPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIW 1300
Query: 719 ---SDAGFPVGSH-----------------------VQYRCLPGYSLEG------AAMLT 746
++AG +G H V + L G +L +++
Sbjct: 1301 TIEAEAGCTIGLHFLVFDTEEVHDVLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVL 1360
Query: 747 CYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELI 806
+S D T K + C +PG+P+NG ++ ++AG+S F C G+ L
Sbjct: 1361 QFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQNGSRS--GDSWEAGDSTVFQCDPGYALQ 1418
Query: 807 GEVTITCVP-GHPSQWTSQPPLC 828
G I+CV + W PP C
Sbjct: 1419 GSAEISCVKIENRFFWQPSPPTC 1441
Score = 176 bits (446), Expect = 9e-44
Identities = 169/712 (23%), Positives = 281/712 (39%), Gaps = 76/712 (10%)
Query: 172 LCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVY-PGYGIEIQVQTLNLSQEEELL 230
+C+ ++ G + SP+ C + I P I++ + +L + + L
Sbjct: 404 MCDAHLRGPSGIITSPNFPIQYDNNA---HCVWIITALNPSKVIKLAFEEFDLERGYDTL 460
Query: 231 VLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-S 289
+ GG G +L + ++ S +++ L FQ+ GF+ Y+ S
Sbjct: 461 TVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGS 520
Query: 290 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASC 349
CG P PA+G + H G T F C ++L G++ + C + W+ + P C+ SC
Sbjct: 521 CGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQ--WSAKKPGCVFSC 578
Query: 350 GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSG 409
+ + G ++SP G +L C W+I A R+HL F + ++ D L+++ G
Sbjct: 579 FFNFTSPS-GVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDG 637
Query: 410 GSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFL 469
+ +PV+ + +P + S +E ++ ++ F F + C P +
Sbjct: 638 ATAEAPVLGTFSGNQLPS-SITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNECPDPGV 696
Query: 470 AHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGG 529
D + G+ +F C G+ L G + WN C+A CGG
Sbjct: 697 PVNGKRFGD-SLQLGSSISFLCDEGF-LGTQGSETITCVLKEGSVVWNSAVLRCEAPCGG 754
Query: 530 ELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDGDGP 588
L+ P+G +LSP WP Y C W + Q I + + D L + DG
Sbjct: 755 HLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYDTLEVRDGRTY 814
Query: 589 SARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP-RNDTCPEL 647
SA ++ G Q + L+S+ L L F + G F L ++ + ++D C +
Sbjct: 815 SAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIG----FQLRYETITLQSDHCLDP 870
Query: 648 PPPEWGWRTASHG-DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM--- 703
P G R HG D G ++T+ C+ GY L + L C+ + WS A P+C+ +
Sbjct: 871 GIPVNGQR---HGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEALCGGF 927
Query: 704 ------TCADPG---------------EIANG-------HRTASDAGFPV------GSHV 729
T PG E ++G H ++G GS
Sbjct: 928 IQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITENGSFT 987
Query: 730 Q-YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYE------------PCLNPGV 776
Q R L G L Y T ++ + ++ YE PC P V
Sbjct: 988 QPLRQLTGSRLPAPISAGLYGNFTAQVRF---ISDFSMSYEGFNITFSEYDLEPCEEPEV 1044
Query: 777 PENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 828
P Y + G++L F C+ G+ L G ITC+ G W+S P C
Sbjct: 1045 P--AYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRC 1094
Score = 172 bits (436), Expect = 1e-42
Identities = 186/761 (24%), Positives = 281/761 (36%), Gaps = 129/761 (16%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C +G V SP+ P + T G + C Y + V Y + Q + + + + V
Sbjct: 1619 CGGQYVGSDGVVLSPNY--PQNYTSGQI-CLYFVTVPKDYVVFGQFAFFHTALNDVVEVH 1675
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPT-NRLLLHFQSPRVPRGGGFRIHYQAY----L 287
G RLL++ S G+ L T N++L+ F + + GF YQA
Sbjct: 1676 DGHSQHS---RLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSA 1732
Query: 288 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN--GTRPSWNGETPSC 345
C P P +G +D G F C+SGY LQG + CL G WN P+C
Sbjct: 1733 TQCSSVPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTC 1792
Query: 346 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 405
+ CGG + G I+SP +L C W I EG + + +++ D L
Sbjct: 1793 VVPCGGNLTERR-GTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLE 1851
Query: 406 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 465
V G ++ VP L S + LY+ S+ + L ++ C
Sbjct: 1852 VFDGADNTVTMLGSFSGTTVPAL-LNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCP 1910
Query: 466 APFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKA 525
P + V T + Y + +F C PGYAL+ I C+ T WN P C A
Sbjct: 1911 EPAVPSNGVKTGE-RYLVNDVVSFQCEPGYALQGHAH---ISCMPGTVRRWNYPPPLCIA 1966
Query: 526 MCGGELSEPAGVVLSPDWPQSYSPGQDCVW--------GVHVQEEKRILLQVEILNVREG 577
CGG + E GV+LSP +P +Y DC W G H+Q +
Sbjct: 1967 QCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQ-------FLNFSTEPNH 2019
Query: 578 DMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLG--------- 628
D + + +G ++R++ + G + LLS+ + T+ F + PG
Sbjct: 2020 DYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYS 2079
Query: 629 -------QGFVLHFKEVPRNDTCP--------------------ELPPPEWGWRTASHGD 661
+GF L E+ R ++ P E P PE G
Sbjct: 2080 HQISSFLRGFDL--SELERTNSTPPVAASYVWDLDPGCEAYELQECPDPEPFANGIVRGA 2137
Query: 662 LIR-GTVLTYQCEPGYELLGSDILTCQ--WDLSWSAAPPACQKIMTCADPGEIANGHRTA 718
G +T++C PGY+L G +LTCQ + +W P C+ + C G I + + T
Sbjct: 2138 GYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCE--VPCG--GNITSSNGTV 2193
Query: 719 SDAGFPVGSHVQYRCL--------PGYSLEGAAMLTCYSRDTGTPKW---SDRVPKCALK 767
GFP C+ G L + + T S D T W P+ +
Sbjct: 2194 YSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFIT-IWDGPQQTAPRLGVF 2252
Query: 768 YEPCLNPGVPENGYQTLYKHH--------------------------------------Y 789
V + Q L K H +
Sbjct: 2253 TRSMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEF 2312
Query: 790 QAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV 830
G+ +R+ C GF L+G +TC G Q+ PP+C+V
Sbjct: 2313 NIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEV 2353
Score = 168 bits (425), Expect = 2e-41
Identities = 168/715 (23%), Positives = 274/715 (38%), Gaps = 84/715 (11%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C + E EG + SP G P + + DC++ I + G+G IQ + + + +
Sbjct: 1968 CGGTVEEMEGVILSP--GFPGNYPSNM-DCSWKIALPVGFGAHIQFLNFSTEPNHDYIEI 2024
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQ-------- 284
G P R++ S L S ++ ++F S GF++ YQ
Sbjct: 2025 RNG--PYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQI 2082
Query: 285 ----------------------------------AY-LLSCGFPPRPAHGDVSVTDLHPG 309
AY L C P A+G V + G
Sbjct: 2083 SSFLRGFDLSELERTNSTPPVAASYVWDLDPGCEAYELQECPDPEPFANGIVRGAGYNVG 2142
Query: 310 GTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGA 369
+ TF C GYQL G L C +GT +W+ P C CGG I ++ G + SP
Sbjct: 2143 QSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNITSSN-GTVYSPGFPSP 2201
Query: 370 VGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSP--VIYDSDMDDVPE 427
+ C W+I G + L+ + + D + + G +P ++ M
Sbjct: 2202 YSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSM----A 2257
Query: 428 RGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP-FLAHGNVTTTDPEYRPGAL 486
+ + + + + A + ++ F A+ +C P L + V T + E+ G +
Sbjct: 2258 KKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDI 2317
Query: 487 ATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGE--LSEPAGVVLSPDWP 544
+ CLPG+ L + C T + P C+ C L++ GV+LS +P
Sbjct: 2318 VRYRCLPGFTLV---GNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYP 2374
Query: 545 QSYSPGQDCVWGVHVQEEKRILLQVE-ILNVREGDMLTLFDGDGPSARVLAQLRGPQPRR 603
SY Q C W V V+ + I L VE L+ ++ D +FDG + +L L G
Sbjct: 2375 GSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAP 2434
Query: 604 RLL-SSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDL 662
++ SS + L++ + G + + +PR P G+
Sbjct: 2435 LIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYCSLPR--------APLHGFILGQTSTQ 2486
Query: 663 IRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPACQKIMTCADPGEIANGHRTA 718
G++ + C GY L+G + C Q WS A P CQ ++C P NG
Sbjct: 2487 PGGSI-HFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQ-ALSCGLPEAPKNGMVFG 2544
Query: 719 SDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR--VPKCALKYEPCLNPGV 776
+ + VG+ Y C GY L+ A T DTG WS+R P+C P ++
Sbjct: 2545 KE--YTVGTKAMYSCSEGYHLQAGAEATAECLDTGL--WSNRNVPPQCVPVTCPDVSSIS 2600
Query: 777 PENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV 830
E+G ++ +++ YQ L C G+ G+ I C P C++
Sbjct: 2601 VEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRI 2655
Score = 140 bits (354), Expect = 4e-33
Identities = 153/572 (26%), Positives = 237/572 (41%), Gaps = 68/572 (11%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C + G VESP G P +CT++I + I++ Q+ L ++ ++L +
Sbjct: 26 CTFQLHGPNGTVESP--GFPYGYP-NYANCTWTITAEEQHRIQLVFQSFALEEDFDVLSV 82
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-SCG 291
G P L + + S L L S GF Y+ +CG
Sbjct: 83 FDG--PPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEVLPSHTCG 140
Query: 292 FPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPS--WNGETPSCMA-- 347
P R +G + + G + C+ G+ L+G L C G+ S W+ PSC A
Sbjct: 141 NPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADD 200
Query: 348 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 407
+CGGT+ + G I SP N C W I A G + L F L++ D L V
Sbjct: 201 ACGGTLRGQS-GIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGYDFLEVT 259
Query: 408 ---------SGGSPLSPVI---------YDSDMDDVPERGLISDAQ-SLYVELLSETPAN 448
+G S +PVI + SD + +RG + Q +EL S
Sbjct: 260 GTEGSSLWFTGASLPAPVISSKNWLRLHFTSD-GNHRQRGFSAQYQVKKQIELKSR---G 315
Query: 449 PLLLSLRFEAFEEDRCFAPFLAHGNVTTTDP-----------EYRPGALATFSCLPGYAL 497
L+ + + + ++ G+ DP ++R G+ F+C GY L
Sbjct: 316 VKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDL 375
Query: 498 EPPGPPNAIECVDPTE--PHWNDTEPACKA-MCGGELSEPAGVVLSPDWPQSYSPGQDCV 554
+ I C+ ++ W+D P C+A MC L P+G++ SP++P Y CV
Sbjct: 376 Q---GSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNNAHCV 432
Query: 555 WGV-HVQEEKRILLQVEILNVREG-DMLTLFDG--DGPSARVLAQLRGPQPRRRLLSSGP 610
W + + K I L E ++ G D LT+ DG DG VL L G ++S+
Sbjct: 433 WIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNH 492
Query: 611 DLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTAS---HGDLIRGTV 667
+ L FQ G GF ++E+ + +C + P +G R S HGD
Sbjct: 493 QMWLLFQT----DGSGSSLGFKASYEEIEQG-SCGDPGIPAYGRREGSRFHHGD-----T 542
Query: 668 LTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 699
L ++C+P +EL+G +TCQ + WSA P C
Sbjct: 543 LKFECQPAFELVGQKAITCQKNNQWSAKKPGC 574
Score = 138 bits (347), Expect = 3e-32
Identities = 192/840 (22%), Positives = 296/840 (35%), Gaps = 152/840 (18%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C + G + SP S DCT++I G I + L + L +
Sbjct: 202 CGGTLRGQSGIISSPHFPSEYHNNA---DCTWTILAELGDTIALVFIDFQLEDGYDFLEV 258
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPT----NRLLLHFQSPRVPRGGGFRIHYQAYLL 288
G SS+ G L +P N L LHF S R GF YQ
Sbjct: 259 TG----------TEGSSLWFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQ 308
Query: 289 ---------------------------------SCGFPPRPAHGDVSVTDLHPGGTATFH 315
C P P G +D G + F
Sbjct: 309 IELKSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFT 368
Query: 316 CDSGYQLQGEETLICLNGTR--PSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPN 373
C+ GY LQG + + C+ + +W+ P C A G I SP N
Sbjct: 369 CNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNN 428
Query: 374 LTCRWVIEAAEGRR-LHLHFERVSLDEDNDRLMVRSGGSP--LSPVIYDSDMDDVPERGL 430
C W+I A + + L FE L+ D L V GG V+Y VP+ +
Sbjct: 429 AHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPDL-I 487
Query: 431 ISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFL-AHGNVTTTDPEYRPGALATF 489
+S +++ ++ + L +E E+ C P + A+G + G F
Sbjct: 488 VSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDPGIPAYGR--REGSRFHHGDTLKF 545
Query: 490 SCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSP 549
C P + L AI C + W+ +P C C + P+GVVLSP++P+ Y
Sbjct: 546 ECQPAFELVGQ---KAITCQKNNQ--WSAKKPGCVFSCFFNFTSPSGVVLSPNYPEDYGN 600
Query: 550 GQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSS 608
CVW + + E RI L ++V + D L + DG A VL G Q + SS
Sbjct: 601 HLHCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSS 660
Query: 609 GPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIR-GTV 667
G L+FQ G F R++ CP+ P G R GD ++ G+
Sbjct: 661 GHVARLEFQTDHSTGKRGFNITFTTF-----RHNECPDPGVPVNGKR---FGDSLQLGSS 712
Query: 668 LTYQCEPGY-ELLGSDILTC---QWDLSWSAAPPACQKIMTCADP--GEIANGHRTASDA 721
+++ C+ G+ GS+ +TC + + W++A ++ C P G + + T
Sbjct: 713 ISFLCDEGFLGTQGSETITCVLKEGSVVWNSA------VLRCEAPCGGHLTSPSGTILSP 766
Query: 722 GFPVGSHVQYRCL------PGYSLE-----------------------GAAMLTCYSRDT 752
G+P C PGY ++ A ++ Y T
Sbjct: 767 GWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYDTLEVRDGRTYSAPLIGVY-HGT 825
Query: 753 GTPKW------------------SD-----RVPKCALKYEPCLNPGVPENGYQTLYKHHY 789
P++ SD R L+ + CL+PG+P NG + + + +
Sbjct: 826 QVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETITLQSDHCLDPGIPVNGQR--HGNDF 883
Query: 790 QAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV-----TQTTDPSRQLEGGN 844
G + F C G+ L + C P QW+ P C+ Q + + G
Sbjct: 884 YVGALVTFSCDSGYTLSDGEPLECEPNF--QWSRALPSCEALCGGFIQGSSGTILSPGFP 941
Query: 845 LALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYEAGDTR 904
L +I G +++T F H Y IT F+ PL + +R
Sbjct: 942 DFYPNNLNCTWIIETSHGKGVFFT----FHTFHLESGHDYLLITENGSFTQPLRQLTGSR 997
Score = 118 bits (295), Expect = 3e-26
Identities = 159/627 (25%), Positives = 226/627 (36%), Gaps = 88/627 (14%)
Query: 287 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSC 345
++SCG P P +G T G TA F C+SGY L G C+ NG W+G C
Sbjct: 2655 IISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGL---WSGSEVRC 2711
Query: 346 MASCGGTIHNATLGRIVSPEP---GGAVGPNLTCRW--VIEAAEGRRLHLHFERVSLDED 400
+A GT PEP G G N + R V + G RL R+ +
Sbjct: 2712 LAGHCGT-----------PEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDH 2760
Query: 401 NDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFE 460
+ SG +P ++ P + D+ ++ + L+
Sbjct: 2761 H-----WSGKTPFCVLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCG 2815
Query: 461 EDRCFAPFLAHGNVTTT----DP-----------EYRPGALATFSCLPGYALEPPGPPNA 505
D + L H + T+ DP + PG + FSC G+ L +
Sbjct: 2816 LDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLR-----GS 2870
Query: 506 IECVDPTEPHWNDTEPACKAMCGGELSEP--AGVVLSPDWPQSYSPGQDCVWGVHVQEEK 563
E W+ ++P C + G P A VV S S S +C G +
Sbjct: 2871 SERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATG-- 2928
Query: 564 RILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDL----TLQFQAP 619
L R + + G P V+ P L G D T+ +Q
Sbjct: 2929 --------LLSRHCSVNGTWTGSDPECLVI-NCGDPGIPANGLRLGNDFRYNKTVTYQCV 2979
Query: 620 PGPPNPGLGQGFVLHFKEVPRNDTCPEL------PPPEWGWRTASHGDLIRGTVLTYQCE 673
PG + K+ N T P PPP D + G+ +TY C
Sbjct: 2980 PGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGSSVTYACL 3039
Query: 674 PGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRC 733
GY+L + TC+ + SW+ P C + C DPG + G R D GF S V + C
Sbjct: 3040 EGYQLSLPAVFTCEGNGSWTGELPQCFPVF-CGDPGVPSRGRR--EDRGFSYRSSVSFSC 3096
Query: 734 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCA-LKYEPCLNPGVPENGYQTLYKHHYQAG 792
P L G+ C S T WS P C C +PGVP+ G Q YQ G
Sbjct: 3097 HPPLVLVGSPRRFCQSDGT----WSGTQPSCIDPTLTTCADPGVPQFGIQN-NSQGYQVG 3151
Query: 793 ESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLP 852
++ F C +G+ L G T TC+P W+ PP C P
Sbjct: 3152 STVLFRCQKGYLLQGSTTRTCLPN--LTWSGTPPDCVPHHCRQPETPTHAN--------- 3200
Query: 853 LGLVIVLGSGVYIYYTKLQGKSLFGFS 879
+G + + G + Y+ +G SL G S
Sbjct: 3201 VGALDLPSMGYTLIYSCQEGFSLKGGS 3227
Score = 102 bits (253), Expect = 2e-21
Identities = 139/573 (24%), Positives = 200/573 (34%), Gaps = 129/573 (22%)
Query: 287 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 346
L+SCG P P H +S G + C L G T +C G W G P C
Sbjct: 2771 LVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMC--GLDGHWTGSLPHCS 2828
Query: 347 ASCGGTI-------HNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDE 399
+ G H LG S +PG + + V+ + R +
Sbjct: 2829 GTSVGVCGDPGIPAHGIRLGD--SFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQP 2886
Query: 400 DNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY--------VELLSE------- 444
+ + + G+P + + SD GL+ + +Y LLS
Sbjct: 2887 ECGVISCGNPGTPSNARVVFSD-------GLVFSSSIVYECREGYYATGLLSRHCSVNGT 2939
Query: 445 -TPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPP 503
T ++P L + C P + N ++R T+ C+PGY +E
Sbjct: 2940 WTGSDPECLVIN--------CGDPGIP-ANGLRLGNDFRYNKTVTYQCVPGYMMESHRV- 2989
Query: 504 NAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEK 563
+ + C + WN T+P CKA+ + +P ++ P G D +WG V
Sbjct: 2990 SVLSCTK--DRTWNGTKPVCKAL----MCKPPPLI-----PNGKVVGSDFMWGSSVTYA- 3037
Query: 564 RILLQVEILNVREGDMLTL-----FDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQA 618
EG L+L +G+G L P F
Sbjct: 3038 ----------CLEGYQLSLPAVFTCEGNGSWTGEL----------------PQCFPVFCG 3071
Query: 619 PPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYEL 678
PG P+ G R G R +V ++ C P L
Sbjct: 3072 DPGVPSRG----------------------------RREDRGFSYRSSV-SFSCHPPLVL 3102
Query: 679 LGSDILTCQWDLSWSAAPPAC--QKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPG 736
+GS CQ D +WS P+C + TCADPG G + S G+ VGS V +RC G
Sbjct: 3103 VGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQ-GYQVGSTVLFRCQKG 3161
Query: 737 YSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLR 796
Y L+G+ TC T WS P C + C P P + G +L
Sbjct: 3162 YLLQGSTTRTCLPNLT----WSGTPPDCVPHH--CRQPETPTHANVGALDLP-SMGYTLI 3214
Query: 797 FFCYEGFELIG-EVTITCVPGHPSQWTSQPPLC 828
+ C EGF L G TC WT +PP+C
Sbjct: 3215 YSCQEGFSLKGGSEHRTCKAD--GSWTGKPPIC 3245
Score = 99.0 bits (245), Expect = 2e-20
Identities = 100/396 (25%), Positives = 156/396 (39%), Gaps = 17/396 (4%)
Query: 171 VLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELL 230
V C NI+ G V SP SP S + DC + I V G+G+ + + L + +
Sbjct: 2180 VPCGGNITSSNGTVYSPGFPSPYSSSQ---DCVWLITVPIGHGVRLNLSLLQTEPSGDFI 2236
Query: 231 VLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSC 290
+ G APRL + + + + ++S +N++LL F GG F I + AY L+
Sbjct: 2237 TI-WDGPQQTAPRLGVFTRSMAK-KTVQSSSNQVLLKFHRD-AATGGIFAIAFSAYPLTK 2293
Query: 291 GFPPRPAHGDVSVT---DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMA 347
PP VT + + G + C G+ L G E L C GT + G P C
Sbjct: 2294 CPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEV 2353
Query: 348 SC-GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMV 406
C + + G I+S G+ TC W++ + L E ++ D +
Sbjct: 2354 HCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEI 2413
Query: 407 RSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFA 466
G S SP++ + + S + S+Y+ S+ N +R+ A C
Sbjct: 2414 FDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSA---PYCSL 2470
Query: 467 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH-WNDTEPACKA 525
P +PG F C GY L G AI P H W++ P C+A
Sbjct: 2471 PRAPLHGFILGQTSTQPGGSIHFGCNAGYRL--VGHSMAICTRHPQGYHLWSEAIPLCQA 2528
Query: 526 M-CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQ 560
+ CG + G+V ++ C G H+Q
Sbjct: 2529 LSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQ 2564
Score = 60.8 bits (146), Expect = 5e-09
Identities = 57/215 (26%), Positives = 89/215 (41%), Gaps = 20/215 (9%)
Query: 527 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDG 585
C +L P G V SP +P Y +C W + +E+ RI L + + E D+L++FDG
Sbjct: 26 CTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEEDFDVLSVFDG 85
Query: 586 DGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC- 644
+ +L G Q ++S+ L+L+ + QGF ++ +P + TC
Sbjct: 86 PPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVS----AQGFHATYEVLP-SHTCG 140
Query: 645 --PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPA 698
LP T + GD +R Y C G+ L G +LTC + +W P+
Sbjct: 141 NPGRLPNGIQQGSTFNLGDKVR-----YSCNLGFFLEGHAVLTCHAGSENSATWDFPLPS 195
Query: 699 CQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRC 733
C+ C G + S FP H C
Sbjct: 196 CRADDACG--GTLRGQSGIISSPHFPSEYHNNADC 228
Score = 47.4 bits (111), Expect = 6e-05
Identities = 49/159 (30%), Positives = 63/159 (39%), Gaps = 19/159 (11%)
Query: 211 GYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSMLGEGQVLR-SPTNRLLLHFQ 269
G + I Q + S + VL G PG P + G V+R S + L
Sbjct: 2750 GMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGN 2809
Query: 270 SPRVPRGGGFRIHYQAYLLSC--------GFPPRPAHGDVSVTDLHPGGTATFHCDSGYQ 321
S R+ G H+ L C G P PAHG PG F C++G+
Sbjct: 2810 STRMC---GLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHV 2866
Query: 322 LQGEETLIC-LNGTRPSWNGETPSC-MASCG--GTIHNA 356
L+G C NG SW+G P C + SCG GT NA
Sbjct: 2867 LRGSSERTCQANG---SWSGSQPECGVISCGNPGTPSNA 2902
Score = 38.5 bits (88), Expect = 0.029
Identities = 18/64 (28%), Positives = 28/64 (43%)
Query: 284 QAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETP 343
+ +++CG P PA+G D T T+ C GY ++ + +WNG P
Sbjct: 2946 ECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKP 3005
Query: 344 SCMA 347
C A
Sbjct: 3006 VCKA 3009
Score = 32.0 bits (71), Expect = 2.7
Identities = 17/56 (30%), Positives = 31/56 (55%), Gaps = 2/56 (3%)
Query: 844 NLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYE 899
++A AIL+P +I+ G +Y+Y + + K F+G + V + F NP+Y+
Sbjct: 3410 SVAAAILVPFIALIIAGFVLYLYKHRRRPK--VPFNGYAGHENTNVRATFENPMYD 3463
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 226 bits (575), Expect = 1e-58
Identities = 166/535 (31%), Positives = 247/535 (46%), Gaps = 25/535 (4%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C ++ EG + SP+ S +C Y I G GI ++ ++ L + + L V
Sbjct: 1105 CGASVKGNEGTLLSPNFPSNYDNNH---ECIYKIETEAGKGIHLRTRSFQLFEGDTLKVY 1161
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAY-LLSCG 291
G S + +LG +L S +N L L F + GF++ Y ++ L+ C
Sbjct: 1162 DGKDSSSRPLGTFTKNELLG--LILNSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLVKCE 1219
Query: 292 FPPRPAHGDVSVTDLHPGGTATFH-CDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 350
P P +G + H T + C+ GY + G TL CL+G R W+ PSC+A CG
Sbjct: 1220 DPGIPNYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIAECG 1279
Query: 351 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 410
G IH AT GRI+SP NL C W+IEA G+ + LHF + +D L V G
Sbjct: 1280 GQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMAHDILKVWDGP 1339
Query: 411 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 470
++ + +PE + S SL ++ S+ + S++F C P +
Sbjct: 1340 VDSDILLKEWSGSALPE-DIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAATCNDPGMP 1398
Query: 471 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEP-HWNDTEPACKAMCGG 529
N T G TF C PGY L+ I CV W P C A CGG
Sbjct: 1399 Q-NGTRYGDSREAGDTVTFQCDPGYQLQGQA---KITCVQLNNRFFWQPDPPTCIAACGG 1454
Query: 530 ELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDGDGP 588
L+ PAGV+LSP++PQ Y PG++C W V V + I L + N+ D L +++G+
Sbjct: 1455 NLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHIYEGEDS 1514
Query: 589 SARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELP 648
++ ++ +G Q R+ SSG L L F++ + GL GF + FKE PR + C +
Sbjct: 1515 NSPLIGSYQGSQAPERIESSGNSLFLAFRS---DASVGL-SGFAIEFKEKPR-EACFDPG 1569
Query: 649 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPAC 699
G R + D G+ +TYQC+ GY++L +TC SW P+C
Sbjct: 1570 NIMNGTRVGT--DFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSC 1622
Score = 211 bits (538), Expect = 2e-54
Identities = 197/736 (26%), Positives = 304/736 (41%), Gaps = 107/736 (14%)
Query: 171 VLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELL 230
V C+ N ++ G + SP P L +C + I V G GI+IQV + Q + L
Sbjct: 1801 VPCSGNFTQRRGTILSPGYPEPYGNNL---NCIWKIIVTEGSGIQIQVISFATEQNWDSL 1857
Query: 231 VLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAY-LLS 289
+ GG APRL + S +L S +N+L LHFQS GF + Y+ L +
Sbjct: 1858 EIHDGGDV-TAPRLGSFSGTTVPA-LLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAA 1915
Query: 290 CGFPPRPAHGDVSVTDLHP-GGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMAS 348
C P P++ + + D + +F C+ GY LQG + C+ GT WN +P C+A+
Sbjct: 1916 CQEPALPSNS-IKIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIAT 1974
Query: 349 CGGTIHNATLGRIV-SPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 407
CGGT+ +TLG ++ SP G+ NL C W I G H+ F S + ++D L ++
Sbjct: 1975 CGGTL--STLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEANHDFLEIQ 2032
Query: 408 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRC-FA 466
+G SP+I D+P L+S + S+ N L ++A+E C
Sbjct: 2033 NGPYHTSPMIGQFSGTDLPA-ALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNCPDP 2091
Query: 467 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM 526
P +G + +D Y G +F C PGY L G P + C +WN P C A
Sbjct: 2092 PPFQNGYMINSD--YSVGQSVSFECYPGYILI--GHP-VLTCQHGINRNWNYPFPRCDAP 2146
Query: 527 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRI-----LLQVEILNVREGDMLT 581
CG ++ G + SP +P Y +DC+W + V + LLQ E +N D +
Sbjct: 2147 CGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVN----DYIA 2202
Query: 582 LFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFK--EVP 639
++DG ++ L G SS + L+F + + G FVL+F ++
Sbjct: 2203 VWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHS-----DFSNGGFFVLNFHAFQLK 2257
Query: 640 RNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQW--DLSWSAAPP 697
+ P +P E D G + YQC PGY L+G+DILTC+ L + + P
Sbjct: 2258 KCQPPPAVPQAE---MLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLP 2314
Query: 698 ACQK--------------IMTCADPGEIANGHRTA-------------------SDAGFP 724
C+ I++ PG N + S+ F
Sbjct: 2315 TCEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQFD 2374
Query: 725 V------------------GSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV----P 762
G+H + ++ + +S D T K ++ P
Sbjct: 2375 ALEVFDGSSGQSPLLVVLSGNHTEQ---SNFTSRSNQLYLRWSTDHATSKKGFKIRYAAP 2431
Query: 763 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQ 820
C+L + P N G+ L + G + +FC G+ ++G TC P Q
Sbjct: 2432 YCSLTH-PLKNGGI-------LNRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQ 2483
Query: 821 WTSQPPLCKVTQTTDP 836
W S PLC+ P
Sbjct: 2484 WDSLTPLCQAVSCGIP 2499
Score = 208 bits (529), Expect = 2e-53
Identities = 159/557 (28%), Positives = 248/557 (44%), Gaps = 38/557 (6%)
Query: 182 GYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLA 241
G + SP +P L CT+ I PG I + + ++L + G P +
Sbjct: 1288 GRILSPGYPAPYDNNL---HCTWIIEADPGKTISLHFIVFDTEMAHDILKVWDG--PVDS 1342
Query: 242 PRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CGFPPRPAHGD 300
LL S + + S N L L F S GF I + + + C P P +G
Sbjct: 1343 DILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAATCNDPGMPQNGT 1402
Query: 301 VSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGETPSCMASCGGTIHNATLG 359
G T TF CD GYQLQG+ + C+ R W + P+C+A+CGG + G
Sbjct: 1403 RYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACGGNL-TGPAG 1461
Query: 360 RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYD 419
I+SP P C W ++ + L F+ +++ D L + G SP+I
Sbjct: 1462 VILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHIYEGEDSNSPLIGS 1521
Query: 420 SDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV---TT 476
PER + S SL++ S+ ++ F+ + CF P GN+ T
Sbjct: 1522 YQGSQAPER-IESSGNSLFLAFRSDASVGLSGFAIEFKEKPREACFDP----GNIMNGTR 1576
Query: 477 TDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTE--PHWNDTEPACKAMCGGELSEP 534
+++ G+ T+ C GY + P ++I CV + P W+ P+C A CGG+ +
Sbjct: 1577 VGTDFKLGSTITYQCDSGYKILDP---SSITCVIGADGKPSWDQVLPSCNAPCGGQYTGS 1633
Query: 535 AGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLA 594
GVVLSP++P +Y+ GQ C++ + V +E + Q D+ LFDG AR+L+
Sbjct: 1634 EGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAELFDGTHAQARLLS 1693
Query: 595 QLRGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPR-NDT-CPELPPPE 651
L G L L++ + L+F A G +GF ++ VPR +DT C +P P
Sbjct: 1694 SLSGSHSGETLPLATSNQILLRFSAKSG----ASARGFHFVYQAVPRTSDTQCSSVPEPR 1749
Query: 652 WGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD----LSWSAAPPACQKIMTCAD 707
+G R S + G+++ ++C PGY L GS L CQ W+ P+C ++ C+
Sbjct: 1750 YGRRIGS--EFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSC--VVPCS- 1804
Query: 708 PGEIANGHRTASDAGFP 724
G T G+P
Sbjct: 1805 -GNFTQRRGTILSPGYP 1820
Score = 187 bits (474), Expect = 5e-47
Identities = 187/740 (25%), Positives = 291/740 (39%), Gaps = 89/740 (12%)
Query: 152 ETTTTIITTTTVTTTVTSP---VLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHV 208
E+ T I+ V + T P C +++ G + P +L C + I
Sbjct: 735 ESITCILQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSL---HCEWIIEA 791
Query: 209 YPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHF 268
PG+ I+I + L + G P + L+ Q L S N + L F
Sbjct: 792 KPGHSIKITFDRFQTEVNYDTLEVRDG--PASSSPLIGEYHGTQAPQFLISTGNFMYLLF 849
Query: 269 QSPRVPRGGGFRIHYQAYLL---SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGE 325
+ GF IHY++ L SC P P +G D T TF CD GY L +
Sbjct: 850 TTDNSRSSIGFLIHYESVTLESDSCLDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDD 909
Query: 326 ETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEG 385
E L+C + WN PSC A CGG I + G ++SP +L C W IE + G
Sbjct: 910 EPLVCERNHQ--WNHALPSCDALCGGYIQGKS-GTVLSPGFPDFYPNSLNCTWTIEVSHG 966
Query: 386 RRLHLHFERVSLDEDNDRLMVRSGGSPLSPV--IYDSDMDDVPERGLISDAQSLYVELLS 443
+ + + F L+ +D L++ GS PV + S + + GL + + + +S
Sbjct: 967 KGVQMIFHTFHLESSHDYLLITEDGSFSEPVARLTGSVLPHTIKAGLFGNFTA-QLRFIS 1025
Query: 444 ETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPP 503
+ + ++ F ++ + C P + + + G TFSC GY LE
Sbjct: 1026 DFSISYEGFNITFSEYDLEPCDDPGVPAFS-RRIGFHFGVGDSLTFSCFLGYRLEGA--- 1081
Query: 504 NAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEK 563
+ C+ W+ P C A CG + G +LSP++P +Y +C++ + + K
Sbjct: 1082 TKLTCLGGGRRVWSAPLPRCVAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGK 1141
Query: 564 RILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPD-LTLQFQAPPGP 622
I L+ + EGD L ++DG S+R L + +L+S + L L+F
Sbjct: 1142 GIHLRTRSFQLFEGDTLKVYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSD 1201
Query: 623 PNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSD 682
+ QGF L + C + P +G+R G TV+ Y C PGY + GS+
Sbjct: 1202 TD----QGFQLTYTSFDL-VKCEDPGIPNYGYRIRDEGH-FTDTVVLYSCNPGYAMHGSN 1255
Query: 683 ILTCQWDLS-----WSAAPPACQKIMTC-------------------------------- 705
LTC LS W P+C I C
Sbjct: 1256 TLTC---LSGDRRVWDKPLPSC--IAECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIE 1310
Query: 706 ADPGEIANGHRTASDAGF----------PVGSHVQYRCLPGYSLEG------AAMLTCYS 749
ADPG+ + H D PV S + + G +L ++ +
Sbjct: 1311 ADPGKTISLHFIVFDTEMAHDILKVWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFD 1370
Query: 750 RDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEV 809
D K + C +PG+P+NG T Y +AG+++ F C G++L G+
Sbjct: 1371 SDFFISKSGFSIQFSTSIAATCNDPGMPQNG--TRYGDSREAGDTVTFQCDPGYQLQGQA 1428
Query: 810 TITCVP-GHPSQWTSQPPLC 828
ITCV + W PP C
Sbjct: 1429 KITCVQLNNRFFWQPDPPTC 1448
Score = 178 bits (452), Expect = 2e-44
Identities = 154/585 (26%), Positives = 250/585 (42%), Gaps = 29/585 (4%)
Query: 149 GEEETTTTIITTTTVTTTVTSPVL----CNNNISEGEGYVESPDLGSPVSRTLGLLDCTY 204
G + T +T T + P+ C +N+ G + SP+ PV C +
Sbjct: 384 GSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNY--PVQYEDNA-HCVW 440
Query: 205 SIHVY-PGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNR 263
I P I++ + L + + L + G G +L + ++ S +N+
Sbjct: 441 VITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQ 500
Query: 264 LLLHFQSPRVPRGGGFRIHYQAYLL-SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQL 322
+ LH QS GF+ YQ CG P PA+G + + G T TF C + ++L
Sbjct: 501 MWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTFECPAAFEL 560
Query: 323 QGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEA 382
GE + C + W+G PSC+ SC A+ G I+SP G N+ C W+I +
Sbjct: 561 VGERVITCQQNNQ--WSGNKPSCVFSCFFNF-TASSGIILSPNYPEEYGNNMNCVWLIIS 617
Query: 383 AEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELL 442
G R+HL F ++ D L V+ G V+ ++VP + L S + +E
Sbjct: 618 EPGSRIHLIFNDFDVEPQFDFLAVKDDGISDITVLGTFSGNEVPSQ-LASSGHIVRLEFQ 676
Query: 443 SETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGP 502
S+ ++ + F ++ C P + D + G+ +F C G+ ++ G
Sbjct: 677 SDHSTTGRGFNITYTTFGQNECHDPGIPINGRRFGD-RFLLGSSVSFHCDDGF-VKTQGS 734
Query: 503 PNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEE 562
+ + W+ T P C+A CGG L+ +GV+L P WP Y C W + +
Sbjct: 735 ESITCILQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPG 794
Query: 563 KRILLQVEILNVREG-DMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPG 621
I + + D L + DG S+ ++ + G Q + L+S+G + L F
Sbjct: 795 HSIKITFDRFQTEVNYDTLEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTT--- 851
Query: 622 PPNPGLGQGFVLHFKEVP-RNDTCPELPPPEWGWRTASHGDL-IRGTVLTYQCEPGYELL 679
N GF++H++ V +D+C + P G R GD IR TV T+ C+PGY L
Sbjct: 852 -DNSRSSIGFLIHYESVTLESDSCLDPGIPVNGHRHG--GDFGIRSTV-TFSCDPGYTLS 907
Query: 680 GSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 724
+ L C+ + W+ A P+C + C G I T GFP
Sbjct: 908 DDEPLVCERNHQWNHALPSCDAL--CG--GYIQGKSGTVLSPGFP 948
Score = 178 bits (452), Expect = 2e-44
Identities = 177/722 (24%), Positives = 274/722 (37%), Gaps = 95/722 (13%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C + EG V SP+ P + T G + C YSI V + + Q + + +
Sbjct: 1626 CGGQYTGSEGVVLSPNY--PHNYTAGQI-CLYSITVPKEFVVFGQFAYFQTALNDLAELF 1682
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPT-NRLLLHFQSPRVPRGGGFRIHYQAYLLS-- 289
G + RLL++ S G+ L T N++LL F + GF YQA +
Sbjct: 1683 DGTHAQA---RLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAVPRTSD 1739
Query: 290 --CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN--GTRPSWNGETPSC 345
C P P +G ++ G F C+ GY LQG L C + WN PSC
Sbjct: 1740 TQCSSVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSC 1799
Query: 346 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 405
+ C G G I+SP G NL C W I EG + + + +++ D L
Sbjct: 1800 VVPCSGNFTQRR-GTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLE 1858
Query: 406 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 465
+ GG +P + VP L S + LY+ S+ L ++ C
Sbjct: 1859 IHDGGDVTAPRLGSFSGTTVPAL-LNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQ 1917
Query: 466 APFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKA 525
P L ++ D Y + +F C PGY L+ + I C+ T WN P C A
Sbjct: 1918 EPALPSNSIKIGD-RYMVNDVLSFQCEPGYTLQGR---SHISCMPGTVRRWNYPSPLCIA 1973
Query: 526 MCGGELSEPAGVVLSPDWPQSYSPGQDCVW--------GVHVQEEKRILLQVEILNVREG 577
CGG LS GV+LSP +P SY DC W G H+Q +
Sbjct: 1974 TCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQ-------FLNFSTEANH 2026
Query: 578 DMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKE 637
D L + +G ++ ++ Q G LLS+ + + F + QGF L ++
Sbjct: 2027 DFLEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNR----QGFKLAYQA 2082
Query: 638 VPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDL--SWSAA 695
+ CP+ PP + G+ S D G ++++C PGY L+G +LTCQ + +W+
Sbjct: 2083 YELQN-CPDPPPFQNGYMINS--DYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYP 2139
Query: 696 PPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCL------PGYSL---------- 739
P C C NG T GFP + C+ PG+ +
Sbjct: 2140 FPRCD--APCGYNVTSQNG--TIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTE 2195
Query: 740 -------------EGAAMLTCYSRDTGTPKWSDRVPKCALKY------------------ 768
+ + L +S +T + LK+
Sbjct: 2196 AVNDYIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGFFVLNFHAFQ 2255
Query: 769 -EPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 827
+ C P ++ G+ +++ C+ G+ L+G +TC Q+ P
Sbjct: 2256 LKKCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPT 2315
Query: 828 CK 829
C+
Sbjct: 2316 CE 2317
Score = 172 bits (437), Expect = 1e-42
Identities = 175/716 (24%), Positives = 269/716 (37%), Gaps = 86/716 (12%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C N + G + SP+ + +C + I PG I + ++ + + L +
Sbjct: 585 CFFNFTASSGIILSPNYPEEYGNNM---NCVWLIISEPGSRIHLIFNDFDVEPQFDFLAV 641
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAY-LLSCG 291
G + +L S L S + + L FQS G GF I Y + C
Sbjct: 642 KDDGISDIT--VLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECH 699
Query: 292 FPPRPAHGDVSVTDLHPGGTATFHCDSGY-QLQGEETLIC-LNGTRPSWNGETPSCMASC 349
P P +G G + +FHCD G+ + QG E++ C L W+ P C A C
Sbjct: 700 DPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPC 759
Query: 350 GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSG 409
GG + A+ G I+ P G +L C W+IEA G + + F+R + + D L VR G
Sbjct: 760 GGHL-TASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVNYDTLEVRDG 818
Query: 410 GSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEA--FEEDRCFAP 467
+ SP+I + P+ LIS +Y+ ++ + + + +E+ E D C P
Sbjct: 819 PASSSPLIGEYHGTQAPQ-FLISTGNFMYLLFTTDNSRSSIGFLIHYESVTLESDSCLDP 877
Query: 468 FL-----AHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPA 522
+ HG ++ + TFSC PGY L P V WN P+
Sbjct: 878 GIPVNGHRHGG------DFGIRSTVTFSCDPGYTLSDDEP-----LVCERNHQWNHALPS 926
Query: 523 CKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTL 582
C A+CGG + +G VLSP +P Y +C W + V K + + ++ L
Sbjct: 927 CDALCGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLL 986
Query: 583 FDGDGPSARVLAQLRG---PQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP 639
DG + +A+L G P + L L+F + +GF + F E
Sbjct: 987 ITEDGSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISY----EGFNITFSEYD 1042
Query: 640 RNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPP 697
+ C + P + R H + G LT+ C GY L G+ LTC WSA P
Sbjct: 1043 L-EPCDDPGVPAFSRRIGFHFGV--GDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLP 1099
Query: 698 AC------------QKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAML 745
C +++ P N H G + R EG +
Sbjct: 1100 RCVAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEGDTLK 1159
Query: 746 TCYSRD---------------------TGTPKW-------SDRVPKCALKYE-----PCL 772
+D T W SD L Y C
Sbjct: 1160 VYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLVKCE 1219
Query: 773 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 828
+PG+P GY+ + H+ + + C G+ + G T+TC+ G W P C
Sbjct: 1220 DPGIPNYGYRIRDEGHF-TDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSC 1274
Score = 160 bits (405), Expect = 5e-39
Identities = 196/791 (24%), Positives = 294/791 (37%), Gaps = 133/791 (16%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C N++ G + SP+ P +C + + V P + I + ++ N+ + L +
Sbjct: 1452 CGGNLTGPAGVILSPNYPQPYPPGK---ECDWRVKVNPDFVIALIFKSFNMEPSYDFLHI 1508
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPT------NRLLLHFQSPRVPRGGGFRIHYQAY 286
G +NS ++G Q ++P N L L F+S GF I ++
Sbjct: 1509 YEGED--------SNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEK 1560
Query: 287 LLSCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETP 343
F P V TD G T T+ CDSGY++ ++ C+ G +PSW+ P
Sbjct: 1561 PREACFDPGNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLP 1620
Query: 344 SCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDR 403
SC A CGG + + G ++SP C + I + + F
Sbjct: 1621 SCNAPCGGQ-YTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQ------- 1672
Query: 404 LMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 463
+ L+ + D R L S + S E L +N +LL ++ R
Sbjct: 1673 -------TALNDLAELFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASAR 1725
Query: 464 CFAPFLAHGNVTTTDP----------------EYRPGALATFSCLPGYALEPPGPPNAIE 507
F F+ T+D E+ G++ F C PGY L+ A+
Sbjct: 1726 GFH-FVYQAVPRTSDTQCSSVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGS---TALH 1781
Query: 508 C--VDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRI 565
C V WNDT P+C C G ++ G +LSP +P+ Y +C+W + V E I
Sbjct: 1782 CQSVPNALAQWNDTIPSCVVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGI 1841
Query: 566 LLQV-EILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPN 624
+QV + D L + DG +A L G L S+ L L FQ+
Sbjct: 1842 QIQVISFATEQNWDSLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVA- 1900
Query: 625 PGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGD-LIRGTVLTYQCEPGYELLGSDI 683
GF L +K V C E P + GD + VL++QCEPGY L G
Sbjct: 1901 ---AAGFHLEYKTVGLA-ACQEPALPS---NSIKIGDRYMVNDVLSFQCEPGYTLQGRSH 1953
Query: 684 LTCQWDL--SWSAAPPACQKIMTCAD--------------PGEIANGHRTASDAGFPVG- 726
++C W+ P C I TC PG N P+G
Sbjct: 1954 ISCMPGTVRRWNYPSPLC--IATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGY 2011
Query: 727 -SHVQ-------------------YRCLP------GYSLEGAAMLTCYSR------DTGT 754
+H+Q Y P G L A + T + D
Sbjct: 2012 GAHIQFLNFSTEANHDFLEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQ 2071
Query: 755 PKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCV 814
+ ++ A + + C +P +NGY + Y G+S+ F CY G+ LIG +TC
Sbjct: 2072 NRQGFKLAYQAYELQNCPDPPPFQNGY--MINSDYSVGQSVSFECYPGYILIGHPVLTCQ 2129
Query: 815 PGHPSQWTSQPPLC------KVTQTT----DPSRQLEGGNLALAILLPLGLVIVLGSGVY 864
G W P C VT P E L I L + + G GVY
Sbjct: 2130 HGINRNWNYPFPRCDAPCGYNVTSQNGTIYSPGFPDEYPILKDCIWL---ITVPPGHGVY 2186
Query: 865 IYYTKLQGKSL 875
I +T LQ +++
Sbjct: 2187 INFTLLQTEAV 2197
Score = 139 bits (350), Expect = 1e-32
Identities = 155/573 (27%), Positives = 226/573 (39%), Gaps = 69/573 (12%)
Query: 173 CNNNISEGEGYVESPDL--GSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELL 230
C + G +ESP G P +CT+ I I++ T L ++ ++L
Sbjct: 32 CGGLVQGPNGTIESPGFPHGYP-----NYANCTWIIITGERNRIQLSFHTFALEEDFDIL 86
Query: 231 VLAGGGSP--GLAPRLLA---NSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQA 285
+ G L RL SS++ G +L L F + GF+ Y+
Sbjct: 87 SVYDGQPQQGNLKVRLSGFQLPSSIVSTGSILT-------LWFTTDFAVSAQGFKALYEV 139
Query: 286 YLL-SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL--NGTRPSWNGET 342
+CG P G + T + G + C GY L+G L C+ G SW+
Sbjct: 140 LPSHTCGNPGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPA 199
Query: 343 PSCMA--SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDED 400
P C A +CGGT+ T I SP N C W I A G + L F L+E
Sbjct: 200 PFCRAEGACGGTL-RGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEG 258
Query: 401 NDRLMVRSGGSPL---------SPVIYDSD------MDDVPERGLISDAQ---------- 435
D L + +P SPVI + D R +AQ
Sbjct: 259 YDFLEISGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIELK 318
Query: 436 SLYVELLSETPAN--PLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLP 493
S V++L + +LS A D C P + R GA FSC
Sbjct: 319 SRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQFSCED 378
Query: 494 GYALEPPGPPNAIEC--VDPTEPHWNDTEPACKA-MCGGELSEPAGVVLSPDWPQSYSPG 550
Y L+ +I C V T W+D P C+A CG L P+GV+ SP++P Y
Sbjct: 379 NYVLQ---GSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDN 435
Query: 551 QDCVWGVHVQE-EKRILLQVEILNVREG-DMLTLFDGD--GPSARVLAQLRGPQPRRRLL 606
CVW + + +K I L E + G D LT+ D G + VL L G ++
Sbjct: 436 AHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIV 495
Query: 607 SSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGT 666
S + L Q+ +P GF ++E+ + C + P +G RT S + G
Sbjct: 496 SMSNQMWLHLQSDDSIGSP----GFKAVYQEIEKGG-CGDPGIPAYGKRTGS--SFLHGD 548
Query: 667 VLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 699
LT++C +EL+G ++TCQ + WS P+C
Sbjct: 549 TLTFECPAAFELVGERVITCQQNNQWSGNKPSC 581
Score = 136 bits (343), Expect = 8e-32
Identities = 164/689 (23%), Positives = 261/689 (37%), Gaps = 60/689 (8%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C N++ G + SP G P + L DC + I V PG+G+ I L + + +
Sbjct: 2147 CGYNVTSQNGTIYSP--GFPDEYPI-LKDCIWLITVPPGHGVYINFTLLQTEAVNDYIAV 2203
Query: 233 AGG---GSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS 289
G SP L + + ++ L + S TN++LL F S GG F +++ A+ L
Sbjct: 2204 WDGPDQNSPQLG--VFSGNTAL---ETAYSSTNQVLLKFHSD-FSNGGFFVLNFHAFQLK 2257
Query: 290 -CGFPPRPAHGDVSVTD--LHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 346
C PP ++ D G + C GY L G + L C ++ + G P+C
Sbjct: 2258 KCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCE 2317
Query: 347 ASC-GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 405
A C + + G I+SP G + TC W I+ + + + ++ D L
Sbjct: 2318 AQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQFDALE 2377
Query: 406 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 465
V G S SP++ + + S + LY+ ++ + +R+ A C
Sbjct: 2378 VFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAA---PYCS 2434
Query: 466 APFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH-WNDTEPACK 524
G+ + C PGY + G NA +P + W+ P C+
Sbjct: 2435 LTHPLKNGGILNRTAGAVGSKVHYFCKPGYRMV--GHSNATCRRNPLGMYQWDSLTPLCQ 2492
Query: 525 AM-CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLF 583
A+ CG S G ++ +C G ++ ++ V + D L
Sbjct: 2493 AVSCGIPESPGNGSFTGNEFTLDSKVVYECHEGFKLESSQQATA------VCQEDGLWSN 2546
Query: 584 DGDGPSAR------VLAQLRGPQPRRRLLSSGPDLTLQ--FQAPPGPPNPGL-------- 627
G P+ + + AQL R + S + Q PG G
Sbjct: 2547 KGKPPTCKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQAN 2606
Query: 628 GQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQ 687
G + + R +C L P G + + + G + C GY L+GS + C
Sbjct: 2607 GTWNIGDERPSCRVISCGSLSFPPNGNKIGTL--TVYGATAIFTCNTGYTLVGSHVRECL 2664
Query: 688 WDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTC 747
+ WS + C C P I NGH S GF V Y+C PG+ L G ++ C
Sbjct: 2665 ANGLWSGSETRCLA-GHCGSPDPIVNGH--ISGDGFSYRDTVVYQCNPGFRLVGTSVRIC 2721
Query: 748 YSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIG 807
KWS + P C C +PG P +G+ + + + F C G+ L G
Sbjct: 2722 LQDH----KWSGQTPVCVPI--TCGHPGNPAHGFTN--GSEFNLNDVVNFTCNTGYLLQG 2773
Query: 808 EVTITCVPGHPSQWTSQPPLCKVTQTTDP 836
C QW+S P C+V +DP
Sbjct: 2774 VSRAQCRSN--GQWSSPLPTCRVVNCSDP 2800
Score = 124 bits (310), Expect = 5e-28
Identities = 144/597 (24%), Positives = 232/597 (38%), Gaps = 88/597 (14%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C + + SP S DCT++I PG I + L + + L +
Sbjct: 208 CGGTLRGTSSSISSPHFPSEYENNA---DCTWTILAEPGDTIALVFTDFQLEEGYDFLEI 264
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPT----NRLLLHFQSPRVPRGGGFRIHYQAY-- 286
+G +P S+ G L SP N L LHF S R GF +Q
Sbjct: 265 SGTEAP----------SIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKA 314
Query: 287 --LLSCGFPPRPAH------------GDVSVTDLHP------------------GGTATF 314
L S G P+ G V+D+ P G F
Sbjct: 315 IELKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQF 374
Query: 315 HCDSGYQLQGEETLIC--LNGTRPSWNGETPSCMA-SCGGTIHNATLGRIVSPEPGGAVG 371
C+ Y LQG +++ C + T +W+ P C A +CG + + G I SP
Sbjct: 375 SCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPS-GVITSPNYPVQYE 433
Query: 372 PNLTCRWVIEAAEGRR-LHLHFERVSLDEDNDRLMVRSGGS--PLSPVIYDSDMDDVPER 428
N C WVI + + + L FE L+ D L V G V+Y VP+
Sbjct: 434 DNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDL 493
Query: 429 GLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFL-AHGNVTTTDPEYRPGALA 487
++S + +++ L S+ ++ E+ C P + A+G T + G
Sbjct: 494 -IVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGK--RTGSSFLHGDTL 550
Query: 488 TFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSY 547
TF C + L I C + W+ +P+C C + +G++LSP++P+ Y
Sbjct: 551 TFECPAAFELVGE---RVITCQQNNQ--WSGNKPSCVFSCFFNFTASSGIILSPNYPEEY 605
Query: 548 SPGQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDGPSARVLAQLRGPQPRRRLL 606
+CVW + + RI L +V + D L + D VL G + +L
Sbjct: 606 GNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAVKDDGISDITVLGTFSGNEVPSQLA 665
Query: 607 SSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGT 666
SSG + L+FQ+ + G+GF + + +N+ C + P G R + G+
Sbjct: 666 SSGHIVRLEFQS----DHSTTGRGFNITYTTFGQNE-CHDPGIPINGRRFGDR--FLLGS 718
Query: 667 VLTYQCEPGY-ELLGSDILTC---QWDLSWSAAPPACQKIMTCADPGEIANGHRTAS 719
+++ C+ G+ + GS+ +TC ++ WS+ P C+ GH TAS
Sbjct: 719 SVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCE---------APCGGHLTAS 766
Score = 97.4 bits (241), Expect = 5e-20
Identities = 137/572 (23%), Positives = 200/572 (34%), Gaps = 112/572 (19%)
Query: 348 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 407
+CGG + G I SP C W+I E R+ L F +L+ED D L V
Sbjct: 31 NCGGLVQGPN-GTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEEDFDILSVY 89
Query: 408 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 467
G + +P ++S L + ++ + +E C P
Sbjct: 90 DGQPQQGNLKVRLSGFQLPS-SIVSTGSILTLWFTTDFAVSAQGFKALYEVLPSHTCGNP 148
Query: 468 F-----LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTE-PHWNDTEP 521
+ HG + G +SCLPGY LE I V P W+ P
Sbjct: 149 GEILKGVLHGT------RFNIGDKIRYSCLPGYILEGHAILTCI--VSPGNGASWDFPAP 200
Query: 522 ACKA--MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-D 578
C+A CGG L + + SP +P Y DC W + + I L + EG D
Sbjct: 201 FCRAEGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYD 260
Query: 579 MLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLH---- 634
L + + PS L + P P ++SS L L F + G F +
Sbjct: 261 FLEISGTEAPSI-WLTGMNLPSP---VISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIE 316
Query: 635 -----FKEVPR------------------NDTCPELPPPEWGWRTASHGDLIRGTVLTYQ 671
K +P +D CP+ PE G R S + G + +
Sbjct: 317 LKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRV-GANVQFS 375
Query: 672 CEPGYELLGSDILTCQ----WDLSWSAAPPACQK-------------------------- 701
CE Y L GS +TCQ +WS P C+
Sbjct: 376 CEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDN 435
Query: 702 -----IMTCADPG----------EIANGH--RTASDAGFPVGSHVQYRCLPG-------Y 737
++T DP E+ G+ T DAG + L G
Sbjct: 436 AHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIV 495
Query: 738 SLEGAAMLTCYSRDT-GTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLR 796
S+ L S D+ G+P + + ++ C +PG+P G +T + G++L
Sbjct: 496 SMSNQMWLHLQSDDSIGSPGF--KAVYQEIEKGGCGDPGIPAYGKRT--GSSFLHGDTLT 551
Query: 797 FFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 828
F C FEL+GE ITC +QW+ P C
Sbjct: 552 FECPAAFELVGERVITCQQN--NQWSGNKPSC 581
Score = 92.0 bits (227), Expect = 2e-18
Identities = 58/184 (31%), Positives = 83/184 (45%), Gaps = 15/184 (8%)
Query: 648 PPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD 707
P P + G R TV+ YQC PG+ L+G+ + C D WS P C I TC
Sbjct: 2684 PDPIVNGHISGDGFSYRDTVV-YQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPI-TCGH 2741
Query: 708 PGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALK 767
PG A+G S+ F + V + C GY L+G + C S +WS +P C +
Sbjct: 2742 PGNPAHGFTNGSE--FNLNDVVNFTCNTGYLLQGVSRAQCRSNG----QWSSPLPTC--R 2793
Query: 768 YEPCLNPGVPENGY---QTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ 824
C +PG EN Q + ++ G S+ + C +GF L+G +TC+ W
Sbjct: 2794 VVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMAN--GLWDRS 2851
Query: 825 PPLC 828
P C
Sbjct: 2852 LPKC 2855
Score = 87.8 bits (216), Expect = 4e-17
Identities = 90/359 (25%), Positives = 143/359 (39%), Gaps = 41/359 (11%)
Query: 470 AHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM-CG 528
AHG+ D ++ +L FSC G+ L G P ++ + W+ +P C+A+ CG
Sbjct: 2928 AHGSRLGDD--FKTKSLLRFSCEMGHQLR--GSPERTCLLNGS---WSGLQPVCEAVSCG 2980
Query: 529 GELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGP 588
+ G+++S D S W + + L R + G P
Sbjct: 2981 NPGTPTNGMIVSSDGILFSSSVIYACWEGY---------KTSGLMTRHCTANGTWTGTAP 3031
Query: 589 SARVLAQLRGPQPRRRLLSSGPDLT----LQFQAPPGPPNPGLGQGFVLHFKEVPRNDT- 643
+++ P + G D T + +Q PG + + K+ N +
Sbjct: 3032 DCTIIS-CGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSK 3090
Query: 644 -------CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAP 696
CP+ PP + G T D G+ ++Y C GY+L S IL+C+ W
Sbjct: 3091 PVCKAVLCPQPPPVQNG--TVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEI 3148
Query: 697 PACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPK 756
P C + C DPG A G S F S V ++C + L G++ C + T
Sbjct: 3149 PQCLPVF-CGDPGIPAEGR--LSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGT---- 3201
Query: 757 WSDRVPKCA-LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCV 814
WS P C + C +PG P G Q Y+ G ++ F C +G+ + G T TC+
Sbjct: 3202 WSGIQPTCIDPAHNTCPDPGTPHFGIQN-SSRGYEVGSTVFFRCRKGYHIQGSTTRTCL 3259
Score = 82.8 bits (203), Expect = 1e-15
Identities = 56/180 (31%), Positives = 75/180 (41%), Gaps = 13/180 (7%)
Query: 665 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC--QKIMTCADPGEIANGHRTASDAG 722
G V+ Y C L+G+D CQ D WS A P C C DPG A+G R D
Sbjct: 2879 GAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGDD-- 2936
Query: 723 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 782
F S +++ C G+ L G+ TC + WS P C + C NPG P NG
Sbjct: 2937 FKTKSLLRFSCEMGHQLRGSPERTCLLNGS----WSGLQPVC--EAVSCGNPGTPTNG-M 2989
Query: 783 TLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEG 842
+ S+ + C+EG++ G +T C WT P C + DP G
Sbjct: 2990 IVSSDGILFSSSVIYACWEGYKTSGLMTRHCTAN--GTWTGTAPDCTIISCGDPGTLANG 3047
Score = 82.4 bits (202), Expect = 2e-15
Identities = 132/589 (22%), Positives = 202/589 (34%), Gaps = 135/589 (22%)
Query: 288 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMA 347
+SCG P PA+ ++ G + C L G +T +C + W+G P C
Sbjct: 2858 ISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSH--WSGALPHCTG 2915
Query: 348 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAA--EGRRLHLHFERVSLDEDNDRLM 405
+ G G +P G +G + + ++ + G +L ER L
Sbjct: 2916 NNPGFC-----GDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCL-------- 2962
Query: 406 VRSGGSPLSPVIYDSDMDD--VPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 463
+ S L PV + P G+I + + L S + +
Sbjct: 2963 LNGSWSGLQPVCEAVSCGNPGTPTNGMIVSSDGI---LFSSSVIYACWEGYKTSGLMTRH 3019
Query: 464 CFAPFLAHGNVTTTDPEYR------PGALA---------------TFSCLPGYALEPPGP 502
C A+G T T P+ PG LA ++ C PGY +E
Sbjct: 3020 C----TANGTWTGTAPDCTIISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTS 3075
Query: 503 PNAIECVDPTEPHWNDTEPACKA-MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQE 561
I C + WN ++P CKA +C G V D+ S C+ G +
Sbjct: 3076 AT-IRCTK--DGRWNPSKPVCKAVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDGYQLSH 3132
Query: 562 EKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPG 621
+L E V +G++ P F PG
Sbjct: 3133 SA--ILSCEGRGVWKGEI------------------------------PQCLPVFCGDPG 3160
Query: 622 PPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGS 681
P G G +K + + +QC+ + L+GS
Sbjct: 3161 IPAEGRLSGKSFTYK-----------------------------SEVFFQCKSPFILVGS 3191
Query: 682 DILTCQWDLSWSAAPPAC--QKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSL 739
CQ D +WS P C TC DPG G + +S G+ VGS V +RC GY +
Sbjct: 3192 SRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSS-RGYEVGSTVFFRCRKGYHI 3250
Query: 740 EGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFC 799
+G+ TC + T + ++ +P + E + V T G +L + C
Sbjct: 3251 QGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTF-------GYTLVYTC 3303
Query: 800 YEGFELI-GEVTITCVPGHPSQWTSQPPLCK----------VTQTTDPS 837
+ GF L G TC +WT + P+CK VT+T PS
Sbjct: 3304 HPGFFLAGGSEHRTCKA--DMKWTGKSPVCKSKGVREVNETVTKTPVPS 3350
Score = 79.3 bits (194), Expect = 1e-14
Identities = 58/200 (29%), Positives = 87/200 (43%), Gaps = 12/200 (6%)
Query: 643 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 702
+C P G +S G L +V+ Y C GY+ G C + +W+ P C I
Sbjct: 2978 SCGNPGTPTNGMIVSSDGILFSSSVI-YACWEGYKTSGLMTRHCTANGTWTGTAPDCT-I 3035
Query: 703 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 762
++C DPG +ANG + +D F V Y+C PGY +E T R T +W+ P
Sbjct: 3036 ISCGDPGTLANGIQFGTD--FTFNKTVSYQCNPGYVMEAVTSATI--RCTKDGRWNPSKP 3091
Query: 763 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 822
C K C P +NG T+ ++ G S+ + C +G++L ++C W
Sbjct: 3092 VC--KAVLCPQPPPVQNG--TVEGSDFRWGSSISYSCMDGYQLSHSAILSC--EGRGVWK 3145
Query: 823 SQPPLCKVTQTTDPSRQLEG 842
+ P C DP EG
Sbjct: 3146 GEIPQCLPVFCGDPGIPAEG 3165
Score = 70.9 bits (172), Expect = 5e-12
Identities = 53/179 (29%), Positives = 72/179 (40%), Gaps = 12/179 (6%)
Query: 665 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 724
G + Y C+ G+ LLGS LTC + W + P C I +C PG AN T F
Sbjct: 2821 GMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAI-SCGHPGVPANAVLTGE--LFT 2877
Query: 725 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEP-CLNPGVPENGYQT 783
G+ V Y C SL G C WS +P C C +PG P +G +
Sbjct: 2878 YGAVVHYSCRGSESLIGNDTRVCQE----DSHWSGALPHCTGNNPGFCGDPGTPAHG--S 2931
Query: 784 LYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEG 842
++ LRF C G +L G TC+ W+ P+C+ +P G
Sbjct: 2932 RLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLN--GSWSGLQPVCEAVSCGNPGTPTNG 2988
Score = 61.2 bits (147), Expect = 4e-09
Identities = 47/191 (24%), Positives = 82/191 (42%), Gaps = 15/191 (7%)
Query: 654 WRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAP--PACQKIMTCADPGEI 711
WR S G + C PGY L G +L CQ + +W+ P+C ++++C
Sbjct: 2571 WRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSC-RVISCGSLSFP 2629
Query: 712 ANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPC 771
NG++ + + G+ + C GY+L G+ + C + WS +C + C
Sbjct: 2630 PNGNKIGTLTVY--GATAIFTCNTGYTLVGSHVRECLANGL----WSGSETRCLAGH--C 2681
Query: 772 LNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVT 831
+P NG+ + Y+ +++ + C GF L+G C+ H +W+ Q P+C
Sbjct: 2682 GSPDPIVNGHISGDGFSYR--DTVVYQCNPGFRLVGTSVRICLQDH--KWSGQTPVCVPI 2737
Query: 832 QTTDPSRQLEG 842
P G
Sbjct: 2738 TCGHPGNPAHG 2748
Score = 43.5 bits (101), Expect = 9e-04
Identities = 42/179 (23%), Positives = 70/179 (39%), Gaps = 16/179 (8%)
Query: 657 ASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANG-- 714
A GD I +Q E GY+ L ++S + AP M P +
Sbjct: 240 AEPGDTIALVFTDFQLEEGYDFL---------EISGTEAPSIWLTGMNLPSPVISSKNWL 290
Query: 715 --HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCL 772
H T+ G + Q++ L+ + S+D AL + C
Sbjct: 291 RLHFTSDSNHRRKGFNAQFQVKKAIELKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCP 350
Query: 773 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQWTSQPPLCK 829
+PG+PENG + + G +++F C + + L G +ITC V + W+ P+C+
Sbjct: 351 DPGIPENG-RRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICR 408
Score = 43.1 bits (100), Expect = 0.001
Identities = 22/72 (30%), Positives = 37/72 (51%), Gaps = 5/72 (6%)
Query: 288 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC-M 346
++CG P PAHG + ++ + F C++GY LQG C + + W+ P+C +
Sbjct: 2737 ITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQ--WSSPLPTCRV 2794
Query: 347 ASCG--GTIHNA 356
+C G + NA
Sbjct: 2795 VNCSDPGFVENA 2806
Score = 33.9 bits (76), Expect = 0.71
Identities = 21/54 (38%), Positives = 27/54 (50%), Gaps = 7/54 (12%)
Query: 309 GGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMA-SCG--GTIHNATL 358
G + +HC G+ L G L C+ NG W+ P C+A SCG G NA L
Sbjct: 2821 GMSILYHCKKGFYLLGSSALTCMANGL---WDRSLPKCLAISCGHPGVPANAVL 2871
Score = 33.9 bits (76), Expect = 0.71
Identities = 20/63 (31%), Positives = 29/63 (46%), Gaps = 4/63 (6%)
Query: 287 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQG--EETLICLNGTRPSWNGETPS 344
++SCG P A+G TD T ++ C+ GY ++ T+ C R WN P
Sbjct: 3035 IISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGR--WNPSKPV 3092
Query: 345 CMA 347
C A
Sbjct: 3093 CKA 3095
Score = 33.1 bits (74), Expect = 1.2
Identities = 32/118 (27%), Positives = 45/118 (38%), Gaps = 9/118 (7%)
Query: 236 GSPGL-APRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-----S 289
G PG+ A L+ S + +V + +L S RV + G Q + +
Sbjct: 3157 GDPGIPAEGRLSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNT 3216
Query: 290 CGFPPRPAHG-DVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 346
C P P G S G T F C GY +QG T CL +W+G C+
Sbjct: 3217 CPDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCL--ANLTWSGIQTECI 3272
Score = 33.1 bits (74), Expect = 1.2
Identities = 20/76 (26%), Positives = 35/76 (46%), Gaps = 2/76 (2%)
Query: 824 QPPLCKVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHS 883
Q PL ++ G++A AIL+P +I+ G Y+Y + + K + H
Sbjct: 3468 QDPLNPDQDSSSHYHGTSSGSVAAAILVPFFALILSGFAFYLYKHRTRPKVQYNGYAGHE 3527
Query: 884 YSPITVESDFSNPLYE 899
S ++ F NP+Y+
Sbjct: 3528 NS--NGQASFENPMYD 3541
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 224 bits (570), Expect = 4e-58
Identities = 181/670 (27%), Positives = 291/670 (43%), Gaps = 36/670 (5%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C +S+ G + SP +L DCT++I++ G+G+ +Q + + L +
Sbjct: 2071 CGGAMSDFSGVILSPGFPGNYPSSL---DCTWTINLPIGFGVHLQFVNFSTETIHDYLEV 2127
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGF 292
G S ++ S L S T+ L+F S GF I YQAY L
Sbjct: 2128 RSGSSE--TSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCP 2185
Query: 293 PPRP-AHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGG 351
PRP +G V D G T +F C GY L G L CL+G +WN P C A CGG
Sbjct: 2186 DPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGG 2245
Query: 352 TIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGS 411
I A G I SP C W++ G ++++F + + D + V G
Sbjct: 2246 NI-TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPD 2304
Query: 412 PLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPF-LA 470
SP I + E + S + + ++ S+ + + L + A++ C P +
Sbjct: 2305 QNSPQIGQFSGNTALE-SVYSTSNQILIKFHSDFTTSGFFV-LSYHAYQLRVCQPPPPVP 2362
Query: 471 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAI-ECVDPTEPHWNDTEPACKAMC-G 528
+ + T D E+ G + + CLPG+ L NAI C + P C+ +C
Sbjct: 2363 NAEILTEDDEFEIGDIIRYQCLPGFTLVG----NAILTCRLGERLQMDGAPPVCQVLCPA 2418
Query: 529 GELS-EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNV-REGDMLTLFDGD 586
EL + GV+LSP +P SY Q C W + V++ I + VE +E D+L ++DG
Sbjct: 2419 NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGP 2478
Query: 587 GPSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 645
+ VL L G + S+G ++ LQ+ A G G ++ + P +
Sbjct: 2479 NIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPES---- 2534
Query: 646 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDL----SWSAAPPACQK 701
PP + + G L +V+ + C+ G+ L+G C+ +W A PACQ
Sbjct: 2535 ---PPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQA 2589
Query: 702 IMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV 761
I +C P NG +D + VG+ V Y C GY L + T + GT ++
Sbjct: 2590 I-SCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKT 2646
Query: 762 PKCALKYEPCLNPGVPENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ 820
P+C + P +N + E+G ++ + HY+ + F C G+ +G +I C+P
Sbjct: 2647 PRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWS 2706
Query: 821 WTSQPPLCKV 830
W ++ P C++
Sbjct: 2707 WRNERPYCQI 2716
Score = 212 bits (540), Expect = 1e-54
Identities = 194/740 (26%), Positives = 292/740 (39%), Gaps = 79/740 (10%)
Query: 168 TSPVLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEE 227
T V C +++ +G + SP P L +C + I V G GI++QV +
Sbjct: 1894 TCIVPCGGILTKRKGTILSPGYPEPYDNNL---NCVWKITVPEGAGIQVQVVSFATEHNW 1950
Query: 228 ELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYL 287
+ L GG APRL + S +L S +N L L+FQS GF + Y A
Sbjct: 1951 DSLDFYDGGDNN-APRLGSYSGTTIP-HLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG 2008
Query: 288 L-SCGFPPRPAHGDVSVTDLHP-GGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 345
L SC P P+ G + + D + G +F CD GY LQG + C+ G WN P C
Sbjct: 2009 LDSCPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2067
Query: 346 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 405
+A CGG + + + G I+SP G +L C W I G +HL F S + +D L
Sbjct: 2068 LAQCGGAMSDFS-GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLE 2126
Query: 406 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 465
VRSG S S VI +P L S + S+ N + ++A++ C
Sbjct: 2127 VRSGSSETSTVIGRLSGPQIPS-SLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCP 2185
Query: 466 APF-LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 524
P +G V D + G +F C PGY L +A+ C+ +WN P C+
Sbjct: 2186 DPRPFRNGFVIGND--FTVGQTISFECFPGYTLIGN---SALTCLHGVSRNWNHPLPRCE 2240
Query: 525 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-GDMLTLF 583
A+CGG ++ G + SP +P Y QDC W V V I + +L D +T++
Sbjct: 2241 ALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVW 2300
Query: 584 DGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT 643
DG ++ + Q G + S+ + ++F + GF + +
Sbjct: 2301 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH------SDFTTSGFFVLSYHAYQLRV 2354
Query: 644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQ- 700
C PP + G ++ YQC PG+ L+G+ ILTC+ L APP CQ
Sbjct: 2355 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQV 2414
Query: 701 -------------------------KIMTCADPGEIANGHRTA-------SDAGFPV--- 725
+ CA + G+ ++ F V
Sbjct: 2415 LCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQV 2474
Query: 726 --GSHVQ----------YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLN 773
G ++Q Y + G + +S D G K R+ A C
Sbjct: 2475 YDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY---CST 2531
Query: 774 PGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS--QWTSQPPLCKVT 831
P P +GY + + Q +R+ C GF L+G+ + C W + P C+
Sbjct: 2532 PESPPHGY-IISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAI 2590
Query: 832 QTTDPSRQLEGGNLALAILL 851
P GG L L+
Sbjct: 2591 SCGIPKAPTNGGILTTDYLV 2610
Score = 207 bits (528), Expect = 3e-53
Identities = 186/714 (26%), Positives = 298/714 (41%), Gaps = 82/714 (11%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C + S G + SP +L +C + I PG+ I+I + ++L +
Sbjct: 855 CGGHFSAPSGVILSPGWPGYYKDSL---NCEWVIEAEPGHSIKITFERFQTELNYDVLEV 911
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL---S 289
G P L LL + + Q L S +N + L F + GF+IHY++ + S
Sbjct: 912 HDG--PNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYS 969
Query: 290 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASC 349
C P P HG D G T +F CDSGY+L EE L+C W+ P+C A C
Sbjct: 970 CLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHW--WSHPLPTCDALC 1027
Query: 350 GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSG 409
GG + + G I+SP +L C W ++ G+ + +F L++ +D L++
Sbjct: 1028 GGDVRGPS-GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITEN 1086
Query: 410 GSPLSPV--IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 467
GS P+ + SD+ GL + ++ + +S+ + ++ F + + C P
Sbjct: 1087 GSFTQPLARLTGSDLPPTINAGLYGNFRA-QLRFISDFSISYEGFNITFSEYNLEPCEDP 1145
Query: 468 FLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMC 527
+ + + G TFSC GY LE + I C+ W+ P C A C
Sbjct: 1146 GIPQYG-SRIGFNFGIGDTLTFSCSSGYRLEGT---SEIICLGGGRRVWSAPLPRCVAEC 1201
Query: 528 GGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDG 587
G + G++LSP++P +Y +C++ + VQ K I + ++ +GD+L ++DG
Sbjct: 1202 GASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKD 1261
Query: 588 PSARVLAQLRGPQPRRRLLSS-GPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPE 646
+ +L G R LSS L L+F + G +GF L + + C +
Sbjct: 1262 KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNS----DTEGTDEGFQLVYTSFELSH-CED 1316
Query: 647 LPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQKIMT 704
P++G++ + G G+ + Y C PGY L GS +L C +W P+C I
Sbjct: 1317 PGIPQFGYKISDQGH-FAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC--IAE 1373
Query: 705 CADPGEIANGHRTASDAGFPVGSHVQYRCL------PG--YSLEGAAMLTCYSRDT---- 752
C + + R S G+P RC+ PG SL+ A T S D
Sbjct: 1374 CGGRFKGESSGRILS-PGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVW 1432
Query: 753 GTPKWSDRVPK--------------------------------CALKYE-----PCLNPG 775
P +D + K A+++ C +PG
Sbjct: 1433 DGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPG 1492
Query: 776 VPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ-WTSQPPLC 828
VP NG T + G+++ F C G+EL GE ITC+ W PP+C
Sbjct: 1493 VPMNG--TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1544
Score = 206 bits (524), Expect = 8e-53
Identities = 190/781 (24%), Positives = 318/781 (40%), Gaps = 96/781 (12%)
Query: 179 EGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSP 238
E G + SP P L C + I V PG + +Q + ++L + G
Sbjct: 1381 ESSGRILSPGYPFPYDNNLR---CMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPE 1437
Query: 239 GLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CGFPPRPA 297
+ S++ EG + S N + + F + GF I + + + + C P P
Sbjct: 1438 NDMLLKEISGSLIPEG--IHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPM 1495
Query: 298 HGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGETPSCMASCGGTIHNA 356
+G + PG T F CD GY+LQGEE + C+ R W P C+A CGG + +
Sbjct: 1496 NGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGS 1555
Query: 357 TLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPV 416
+ G I+SP + C W I + L F S++ + D L + G SP+
Sbjct: 1556 S-GFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPL 1614
Query: 417 IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV-- 474
I +PER + S + ++++ S+ + L ++A + CF P GN+
Sbjct: 1615 IGSFQDSKLPER-IESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP----GNIMN 1669
Query: 475 -TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHWNDTEPACKAMCGGEL 531
T +Y+ G+ T+ C GY L+ + + C+ D P WN P+C A CG
Sbjct: 1670 GTRLGMDYKLGSTVTYYCDAGYVLQGY---STLTCIMGDDGRPGWNRALPSCHAPCGSRS 1726
Query: 532 SEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSAR 591
+ G VLSP++P++YS G +CV+ + V +E + Q D++ ++DG +
Sbjct: 1727 TGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSS 1786
Query: 592 VLAQLRGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT--CPELP 648
+L+ L G L LSSG +T++F + P +GF ++ VPR + C +P
Sbjct: 1787 LLSSLSGSHSGESLPLSSGNQITIRFTS----VGPITAKGFHFVYQAVPRTSSTQCSSVP 1842
Query: 649 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC--------QWDLSWSAAPPACQ 700
P +G R + + G+ + + C PGY L GS + C QW+ S C
Sbjct: 1843 EPRFGRRIGN--EFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG 1900
Query: 701 KIMTCADPGEIANGHRTASDAGF--------PVGSHVQYRCLPGYSLE------------ 740
I+T ++ G+ D P G+ +Q + + ++ E
Sbjct: 1901 GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVV-SFATEHNWDSLDFYDGG 1959
Query: 741 --GAAMLTCYS--------------------RDTGTPKWSDRVPKCALKYEPCLNPGVPE 778
A L YS D + A+ + C P P
Sbjct: 1960 DNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPS 2019
Query: 779 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSR 838
+G + Y G+ + F C +G+ L G ITC+PG +W P+C + Q
Sbjct: 2020 SGIK--IGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC-LAQCGGAMS 2076
Query: 839 QLEG--------GNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGF----SGSHSYSP 886
G GN ++ + + +G GV++ + +++ + SGS S
Sbjct: 2077 DFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETST 2136
Query: 887 I 887
+
Sbjct: 2137 V 2137
Score = 182 bits (463), Expect = 9e-46
Identities = 154/570 (27%), Positives = 238/570 (41%), Gaps = 29/570 (5%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C + + EG + SP+ +C YSI V G GI I +T +L+Q + L +
Sbjct: 1201 CGASATNNEGILLSPNYPLNYENNH---ECIYSIQVQAGKGINISARTFHLAQGDVLKIY 1257
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CG 291
G +SM G L S +N+L L F S GF++ Y ++ LS C
Sbjct: 1258 DGKDKTTHLLGAFTGASM--RGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCE 1315
Query: 292 FPPRPAHG-DVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 350
P P G +S G T + C+ GY L G L C+ G R +W+ PSC+A CG
Sbjct: 1316 DPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECG 1375
Query: 351 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 410
G + GRI+SP NL C W+IE G + L F + +D L V G
Sbjct: 1376 GRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGP 1435
Query: 411 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 470
++ + +PE G+ S + ++ ++ + +++F + C P +
Sbjct: 1436 PENDMLLKEISGSLIPE-GIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVP 1494
Query: 471 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH-WNDTEPACKAMCGG 529
N T PG F C PGY L+ I C+ + W + P C A CGG
Sbjct: 1495 M-NGTRNGDGREPGDTVVFQCDPGYELQ---GEERITCIQVENRYFWQPSPPVCIAPCGG 1550
Query: 530 ELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDGDGP 588
L+ +G +LSP++P Y +DC W + V + I L ++ D L ++DG
Sbjct: 1551 NLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDS 1610
Query: 589 SARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELP 648
++ ++ + + R+ SS + L F++ GF L +K R ++C
Sbjct: 1611 NSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSY----TGFHLEYKAKLR-ESC--FD 1663
Query: 649 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPACQKIMT 704
P T D G+ +TY C+ GY L G LTC W+ A P+C
Sbjct: 1664 PGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH--AP 1721
Query: 705 CADPGEIANGHRTASDAGFPVGSHVQYRCL 734
C + G T +P V + C+
Sbjct: 1722 CGSRSTGSEG--TVLSPNYPKNYSVGHNCV 1749
Score = 171 bits (432), Expect = 4e-42
Identities = 193/787 (24%), Positives = 301/787 (38%), Gaps = 119/787 (15%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C N++ G++ SP+ P + DC ++I V Y I + + ++ + L +
Sbjct: 1548 CGGNLTGSSGFILSPNFPHPYPHSR---DCDWTITVNADYVISLAFISFSIEPNYDFLYI 1604
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSP------TNRLLLHFQSPRVPRGGGFRIHYQAY 286
G +NS ++G Q + P +N + L F+S GF + Y+A
Sbjct: 1605 YDGPD--------SNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK 1656
Query: 287 LL-SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETP 343
L SC P +G D G T T++CD+GY LQG TL C+ G RP WN P
Sbjct: 1657 LRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716
Query: 344 SCMASCGGTIHNATLGRIVSPE--PGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN 401
SC A CG + G ++SP +VG N + F + SL +
Sbjct: 1717 SCHAPCGSR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL---H 1772
Query: 402 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAF-- 459
D + V G + S ++ E +S + + S P ++A
Sbjct: 1773 DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPR 1832
Query: 460 -EEDRCFA-PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIEC--VDPTEPH 515
+C + P G E+ G+ F C PGY L AI C V +
Sbjct: 1833 TSSTQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGYILHGS---IAIRCETVPNSLAQ 1887
Query: 516 WNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQV-EILNV 574
WND+ P C CGG L++ G +LSP +P+ Y +CVW + V E I +QV
Sbjct: 1888 WNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATE 1947
Query: 575 REGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLH 634
D L +DG +A L G L S+ +L L FQ+ GF L
Sbjct: 1948 HNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVS----AAGFHLE 2003
Query: 635 FKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSW 692
+ + D+CPE P G + + G V+++QC+ GY L G +TC W
Sbjct: 2004 YTAIGL-DSCPEPQTPSSGIKIGDR--YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRW 2060
Query: 693 SAAPPACQK------------IMTCADPGEIANGHRTASDAGFPVGS--HVQYRCLPGYS 738
+ P C I++ PG + P+G H+Q+ +
Sbjct: 2061 NYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET 2120
Query: 739 LEGAAMLTCYSRDTGTP-------------------------------KWSDRVPKCALK 767
+ + S +T T K + A +
Sbjct: 2121 IHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQ 2180
Query: 768 YEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 827
+ C +P NG+ + + + G+++ F C+ G+ LIG +TC+ G W P
Sbjct: 2181 LQSCPDPRPFRNGF--VIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPR 2238
Query: 828 CKVTQTTDPSRQLEGGNLAL---AILLP------------LGLV-IVLGSGVYIYYTKLQ 871
C+ L GGN+ I P LV + G+G+YI +T LQ
Sbjct: 2239 CEA---------LCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQ 2289
Query: 872 GKSLFGF 878
+ ++ F
Sbjct: 2290 TEPIYDF 2296
Score = 167 bits (422), Expect = 5e-41
Identities = 138/556 (24%), Positives = 231/556 (41%), Gaps = 23/556 (4%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIH-VYPGYGIEIQVQTLNLSQEEELLV 231
C +N+ G SP+ C + I V I+I + +L + L
Sbjct: 508 CGSNLQGPSGTFTSPNFPFQYDSNA---QCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564
Query: 232 LAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-SC 290
+ GG G +L + ++ S ++++ LH Q+ GF+++Y+ SC
Sbjct: 565 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 624
Query: 291 GFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 350
G P P +G F C G++L GE++++C + W+ P C+ C
Sbjct: 625 GDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ--WSANIPICIFPCL 682
Query: 351 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 410
A +G ++SP+ G NL C W I + G R+HL F L+ D L V+ G
Sbjct: 683 SNF-TAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD 741
Query: 411 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 470
SP SP++ +VP L S++ L +E ++ + ++ + F + C P +
Sbjct: 742 SPESPILGTFTGAEVPSH-LTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP 800
Query: 471 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGE 530
N ++ G+ + C G+ ++ G + + W+ P C A CGG
Sbjct: 801 I-NARRFGDNFQLGSSISVICEEGF-IKTQGTETITCILMDGKVMWSGLIPKCGAPCGGH 858
Query: 531 LSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDGPS 589
S P+GV+LSP WP Y +C W + + I + E D+L + DG
Sbjct: 859 FSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLL 918
Query: 590 ARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRND-TCPELP 648
+ +L G Q + L SS + L F N GF +H++ V N +C +
Sbjct: 919 SPLLGSYNGTQVPQFLFSSSNFIYLLFTT----DNSRSNNGFKIHYESVTVNTYSCLDPG 974
Query: 649 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADP 708
P G R D G+ +++ C+ GY L + L C+ + WS P C + C
Sbjct: 975 IPVHGRRYGH--DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL--CG-- 1028
Query: 709 GEIANGHRTASDAGFP 724
G++ T G+P
Sbjct: 1029 GDVRGPSGTILSPGYP 1044
Score = 122 bits (307), Expect = 1e-27
Identities = 105/424 (24%), Positives = 179/424 (42%), Gaps = 32/424 (7%)
Query: 290 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSC-M 346
C P P +G +D G T F CD Y LQG +++ C + +W+ P C +
Sbjct: 446 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 505
Query: 347 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRR-LHLHFERVSLDEDNDRLM 405
+CG + + G SP N C WVI A + + ++FE L+ D L
Sbjct: 506 KTCGSNLQGPS-GTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564
Query: 406 VRSGGSPLSP-----VIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFE 460
+ GG P V+ S + D+ ++S + +++ L ++ + + ++ E
Sbjct: 565 IGDGGEVGDPRTVLQVLTGSFVPDL----IVSMSSQMWLHLQTDESVGSVGFKVNYKEIE 620
Query: 461 EDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 520
++ C P + D + + F C G+ L +I C + + W+
Sbjct: 621 KESCGDPGTPLYGIREGD-GFSNRDVLRFECQFGFELI---GEKSIVCQENNQ--WSANI 674
Query: 521 PACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDM 579
P C C + P G VLSPD+P+ Y +C+W + RI L ++ + D
Sbjct: 675 PICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDF 734
Query: 580 LTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP 639
L + DGD P + +L G + L S+ L L+FQA + G+GF + +
Sbjct: 735 LAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQA----DHSMSGRGFNITYNTFG 790
Query: 640 RNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGY-ELLGSDILTC---QWDLSWSAA 695
N+ CP+ P R + L G+ ++ CE G+ + G++ +TC + WS
Sbjct: 791 HNE-CPDPGIPINARRFGDNFQL--GSSISVICEEGFIKTQGTETITCILMDGKVMWSGL 847
Query: 696 PPAC 699
P C
Sbjct: 848 IPKC 851
Score = 89.0 bits (219), Expect = 2e-17
Identities = 62/203 (30%), Positives = 85/203 (41%), Gaps = 12/203 (5%)
Query: 641 NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 700
N + P +P HG+ GTV+ Y C PGY L GS +L CQ + W P C
Sbjct: 2892 NCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2951
Query: 701 KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 760
I C PG N S + GS V Y C SL G + TC WS
Sbjct: 2952 MI-DCGHPGVPPNA--VLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG----HWSGS 3004
Query: 761 VPKCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS 819
P C+ C +PG P G+ + + +++ ++R+ C G+ L G TC+
Sbjct: 3005 QPHCSGDATGTCGDPGTP--GHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLAN--G 3060
Query: 820 QWTSQPPLCKVTQTTDPSRQLEG 842
WT + P CK Q +P G
Sbjct: 3061 SWTGRQPECKAVQCGNPGTTANG 3083
Score = 85.9 bits (211), Expect = 2e-16
Identities = 63/195 (32%), Positives = 89/195 (45%), Gaps = 21/195 (10%)
Query: 656 TASHGDLIR--GTVLT----YQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPG 709
T ++G + R GT + Y C GY L G + C + +WS P C I++C DPG
Sbjct: 3079 TTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNC-TIISCGDPG 3137
Query: 710 EIANGHRTASDAGFPVGSHVQYRCLPGYSLE--GAAMLTCYSRDTGTPKWSDRVPKCALK 767
ANG R D + VG +V Y C PGY++E G+ + TC T WS +P C +
Sbjct: 3138 IPANGLRYGDD--YVVGQNVSYMCQPGYTMELNGSRIRTCTINGT----WSGVMPTC--R 3189
Query: 768 YEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 827
C P NG L ++ G S+ + C G+EL +TCV W+ + P
Sbjct: 3190 AVTCPTPPQISNG--RLEGTNFDWGFSISYICSPGYELSFPAVLTCVGN--GTWSGEVPQ 3245
Query: 828 CKVTQTTDPSRQLEG 842
C DP +G
Sbjct: 3246 CLPKFCGDPGIPAQG 3260
Score = 83.2 bits (204), Expect = 1e-15
Identities = 62/187 (33%), Positives = 82/187 (43%), Gaps = 13/187 (6%)
Query: 643 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 702
TCP P G ++ D G ++Y C PGYEL +LTC + +WS P C
Sbjct: 3192 TCPTPPQISNGRLEGTNFDW--GFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP- 3248
Query: 703 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 762
C DPG A G R F S V + C + L G++ C + T WS P
Sbjct: 3249 KFCGDPGIPAQGKREGK--SFIYQSEVSFSCNFPFILVGSSTRICQADGT----WSGSSP 3302
Query: 763 KCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 821
C + C NPGVP +G Q +Q G ++F C +G L G T TC+P W
Sbjct: 3303 HCIEPTQTSCENPGVPRHGSQN-NTFGFQVGSVVQFHCKKGHLLQGSTTRTCLP--DLTW 3359
Query: 822 TSQPPLC 828
+ P C
Sbjct: 3360 SGIQPEC 3366
Score = 82.4 bits (202), Expect = 2e-15
Identities = 53/167 (31%), Positives = 74/167 (44%), Gaps = 14/167 (8%)
Query: 664 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF 723
R TV+ YQC PG+ L+GS + CQ D +WS P+C + +C PG G S GF
Sbjct: 2796 RDTVV-YQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV-SCGHPGSPIYGR--TSGNGF 2851
Query: 724 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT 783
V + C GY ++G C + +WS P C K C +PG+P N +
Sbjct: 2852 NFNDVVTFSCNIGYLMQGPTKAQCQA----NRQWSHPPPMC--KVVNCSDPGIPANSKRE 2905
Query: 784 LYKHH--YQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 828
H + G + + C G+ L G + C P QW P C
Sbjct: 2906 SKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN--GQWDKPLPEC 2950
Score = 73.6 bits (179), Expect = 8e-13
Identities = 63/245 (25%), Positives = 97/245 (39%), Gaps = 37/245 (15%)
Query: 643 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 702
+C ELP P G + + G+ + C+ G+ L+GS + C WS + C
Sbjct: 2718 SCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLA- 2774
Query: 703 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 762
C P I NG + G+ V Y+C PG+ L G+++ C WS ++P
Sbjct: 2775 GHCGIPELIVNGQVIGENYGYR--DTVVYQCNPGFRLIGSSVRICQQDHN----WSGQLP 2828
Query: 763 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 822
C C +PG P G + + + + + F C G+ + G C QW+
Sbjct: 2829 SCVPV--SCGHPGSPIYGRTS--GNGFNFNDVVTFSCNIGYLMQGPTKAQCQANR--QWS 2882
Query: 823 SQPPLCKVTQTTDP--------SRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKS 874
PP+CKV +DP ++E GN G ++Y G
Sbjct: 2883 HPPPMCKVVNCSDPGIPANSKRESKIEHGNFTY--------------GTVVFYDCNPGYF 2928
Query: 875 LFGFS 879
LFG S
Sbjct: 2929 LFGSS 2933
Score = 69.7 bits (169), Expect = 1e-11
Identities = 76/278 (27%), Positives = 113/278 (40%), Gaps = 16/278 (5%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C + G +ESP G P G +CT+ I I+I Q+ L +E + L L
Sbjct: 25 CGGTLKGLNGTIESP--GFPYGYPNGA-NCTWVIIAEERNRIQIVFQSFALEEEYDYLSL 81
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CG 291
G R L + S + L S GF+++Y+ S CG
Sbjct: 82 YDGHPHPTNFRTRLTGFHLPPP--VTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 139
Query: 292 FPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETPSCMA-- 347
P P G + T G + C +GY L G L C+ + SW+ P C A
Sbjct: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 199
Query: 348 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 407
+CGGT+ ++ G I SP N C W I A G + L F ++E D L +
Sbjct: 200 ACGGTMRGSS-GIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI- 257
Query: 408 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSET 445
G P P I+ S M+ P +IS+ L + ++++
Sbjct: 258 EGSEP--PTIWLSGMNIPPP--IISNKNWLRLHFVTDS 291
Score = 68.2 bits (165), Expect = 3e-11
Identities = 61/259 (23%), Positives = 104/259 (40%), Gaps = 12/259 (4%)
Query: 348 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 407
+CGGT+ G I SP C WVI A E R+ + F+ +L+E+ D L +
Sbjct: 24 TCGGTLKGLN-GTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLY 82
Query: 408 SGGSPLSPVIYDSDMDDVPERGLISDAQSLY-VELLSETPANPLLLSLRFEAFEEDRCFA 466
G P + + + ++ +S++ + L S+ + + +E + C
Sbjct: 83 DGHP--HPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 140
Query: 467 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHWNDTEPACK 524
P + V + G +SC+ GY L+ G P + C+ W+ P C+
Sbjct: 141 PGVPPKGVLY-GTRFDVGDKIRYSCVTGYILD--GHPQ-LTCIANSVNTASWDFPVPICR 196
Query: 525 A--MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTL 582
A CGG + +G++ SP +P Y DC W + + I L + E
Sbjct: 197 AEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLE 256
Query: 583 FDGDGPSARVLAQLRGPQP 601
+G P L+ + P P
Sbjct: 257 IEGSEPPTIWLSGMNIPPP 275
Score = 57.4 bits (137), Expect = 6e-08
Identities = 95/374 (25%), Positives = 147/374 (39%), Gaps = 72/374 (19%)
Query: 171 VLC--NNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEE 228
VLC N + G + SP G P S L C +SI V GY I + V+ +E +
Sbjct: 2414 VLCPANELRLDSTGVILSP--GYPDSYP-NLQMCAWSISVEKGYNITMFVEFFQTEKEFD 2470
Query: 229 LLVLAGGGSPGL-APRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYL 287
+L + G P + +P L++ S + S + + L + + GFRI Y A+
Sbjct: 2471 VLQVYDG--PNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY 2528
Query: 288 LSCGFPPRPAHGDV-SVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRP--SWNGETPS 344
C P P HG + S T + CD G++L G+ + +C + +W+ P+
Sbjct: 2529 --CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPA 2586
Query: 345 CMA-SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDR 403
C A SC G +P GG LT +++ G R+ D R
Sbjct: 2587 CQAISC---------GIPKAPTNGGI----LTTDYLV----GTRV------TYFCNDGYR 2623
Query: 404 LMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 463
L + L+ + SD G S+ ++TP ++ +F
Sbjct: 2624 LSSKE----LTTAVCQSD-------GTWSNH--------NKTPRCVVVTCPSINSF---- 2660
Query: 464 CFAPFLAHGN---VTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 520
L HG V + EY+ + FSC PGY P +IEC+ W +
Sbjct: 2661 ----ILEHGRWRIVNGSHYEYKTKVV--FSCDPGYHGLGPA---SIECLPNGTWSWRNER 2711
Query: 521 PACKAMCGGELSEP 534
P C+ + GEL P
Sbjct: 2712 PYCQIISCGELPTP 2725
Score = 57.0 bits (136), Expect = 8e-08
Identities = 53/212 (25%), Positives = 83/212 (39%), Gaps = 14/212 (6%)
Query: 527 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDG 585
CGG L G + SP +P Y G +C W + +E RI + + + E D L+L+DG
Sbjct: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 84
Query: 586 DGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 645
+L G + S+ +L+ + GF ++++E+ ++ +C
Sbjct: 85 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVS----AHGFKVYYEEL-QSSSCG 139
Query: 646 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD----LSWSAAPPACQK 701
P G + D+ G + Y C GY L G LTC + SW P C+
Sbjct: 140 NPGVPPKGVLYGTRFDV--GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197
Query: 702 IMTCADPGEIANGHRTASDAGFPVGSHVQYRC 733
C G + S FP H C
Sbjct: 198 EDACG--GTMRGSSGIISSPSFPNEYHNNADC 227
Score = 53.5 bits (127), Expect = 9e-07
Identities = 44/136 (32%), Positives = 57/136 (41%), Gaps = 13/136 (9%)
Query: 236 GSPGLAPRLLANSSMLGEGQVLR-SPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-----S 289
G PG+ P + + G + S T + L QS R + G Q + +
Sbjct: 2956 GHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGT 3015
Query: 290 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMA- 347
CG P P HG ++ T + CD+GY L G E CL NG SW G P C A
Sbjct: 3016 CGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANG---SWTGRQPECKAV 3072
Query: 348 SCG--GTIHNATLGRI 361
CG GT N + RI
Sbjct: 3073 QCGNPGTTANGKVFRI 3088
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/63 (44%), Positives = 33/63 (52%), Gaps = 2/63 (3%)
Query: 705 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 764
C DPGE NG R SD F +GS VQ+ C Y L+GA +TC WSD P C
Sbjct: 446 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503
Query: 765 ALK 767
+K
Sbjct: 504 KVK 506
Score = 52.0 bits (123), Expect = 3e-06
Identities = 40/130 (30%), Positives = 59/130 (45%), Gaps = 14/130 (10%)
Query: 639 PRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPA 698
P +C P G + + G + G+V+ + C+ G+ L GS TC DL+WS P
Sbjct: 3307 PTQTSCENPGVPRHGSQNNTFGFQV-GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPE 3365
Query: 699 CQKIMTCADPGEIANGHRTASDAGFPVGSH---VQYRCLPGYSLEGAA-MLTCYSRDTGT 754
C +C P A+ A+ G + SH + Y C PG+ L G C S +T
Sbjct: 3366 CIP-HSCKQPETPAH----ANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNT-- 3418
Query: 755 PKWSDRVPKC 764
W+ +VP C
Sbjct: 3419 --WTGKVPIC 3426
Score = 48.5 bits (114), Expect = 3e-05
Identities = 45/187 (24%), Positives = 71/187 (37%), Gaps = 18/187 (9%)
Query: 705 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 764
C+ P +G+ S G + S V++ C G+ L G + C G W VP C
Sbjct: 2529 CSTPESPPHGY-IISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2587
Query: 765 ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ 824
+ C P P NG + Y G + +FC +G+ L + T V W++
Sbjct: 2588 --QAISCGIPKAPTNG--GILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNH 2643
Query: 825 PPLCKVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS-GSHS 883
+ T PS + +L G ++ Y Y TK+ +F G H
Sbjct: 2644 NKTPRCVVVTCPSIN--------SFILEHGRWRIVNGSHYEYKTKV----VFSCDPGYHG 2691
Query: 884 YSPITVE 890
P ++E
Sbjct: 2692 LGPASIE 2698
Score = 44.3 bits (103), Expect = 5e-04
Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 4/66 (6%)
Query: 766 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPG--HPSQWTS 823
L+ C NPGVP G LY + G+ +R+ C G+ L G +TC+ + + W
Sbjct: 133 LQSSSCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 190
Query: 824 QPPLCK 829
P+C+
Sbjct: 191 PVPICR 196
Score = 44.3 bits (103), Expect = 5e-04
Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 2/61 (3%)
Query: 704 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 763
+C +PG G F VG ++Y C+ GY L+G LTC + T W VP
Sbjct: 137 SCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 194
Query: 764 C 764
C
Sbjct: 195 C 195
Score = 42.0 bits (97), Expect = 0.003
Identities = 22/65 (33%), Positives = 36/65 (55%), Gaps = 5/65 (7%)
Query: 288 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCM 346
++C PP+ ++G + T+ G + ++ C GY+L L C+ NGT W+GE P C+
Sbjct: 3191 VTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCL 3247
Query: 347 AS-CG 350
CG
Sbjct: 3248 PKFCG 3252
Score = 41.2 bits (95), Expect = 0.004
Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 4/63 (6%)
Query: 766 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQP 825
++ E C +PG P G + + + LRF C GFELIGE +I C +QW++
Sbjct: 619 IEKESCGDPGTPLYGIRE--GDGFSNRDVLRFECQFGFELIGEKSIVCQEN--NQWSANI 674
Query: 826 PLC 828
P+C
Sbjct: 675 PIC 677
Score = 41.2 bits (95), Expect = 0.004
Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 2/81 (2%)
Query: 287 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 346
++SCG P P +G+ T G TA F CD G+ L G CL+ W+ C+
Sbjct: 2716 IISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSS--GLWSESETRCL 2773
Query: 347 ASCGGTIHNATLGRIVSPEPG 367
A G G+++ G
Sbjct: 2774 AGHCGIPELIVNGQVIGENYG 2794
Score = 40.4 bits (93), Expect = 0.008
Identities = 39/148 (26%), Positives = 55/148 (37%), Gaps = 27/148 (18%)
Query: 769 EPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ--WTSQPP 826
E C +PG NG T Y+ G ++ ++C G+ L G T+TC+ G + W P
Sbjct: 1659 ESCFDPGNIMNG--TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1716
Query: 827 LC-------------KVTQTTDPSRQLEGGNLALAILLPLGLVIV---------LGSGVY 864
C V P G N +I +P V+ L V
Sbjct: 1717 SCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVE 1776
Query: 865 IYYTKLQGKSLF-GFSGSHSYSPITVES 891
+Y Q SL SGSHS + + S
Sbjct: 1777 VYDGPTQQSSLLSSLSGSHSGESLPLSS 1804
Score = 40.4 bits (93), Expect = 0.008
Identities = 22/59 (37%), Positives = 27/59 (45%), Gaps = 3/59 (5%)
Query: 289 SCGFPPRPAHGDVSVT-DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 346
SC P P HG + T G FHC G+ LQG T CL +W+G P C+
Sbjct: 3311 SCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDL--TWSGIQPECI 3367
Score = 38.5 bits (88), Expect = 0.029
Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 4/62 (6%)
Query: 771 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQWTSQPPLC 828
C +PG PENG + + G +++F C E + L G +ITC + + W+ P+C
Sbjct: 446 CPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503
Query: 829 KV 830
KV
Sbjct: 504 KV 505
Score = 38.5 bits (88), Expect = 0.029
Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 3/62 (4%)
Query: 290 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-AS 348
CG P +G V + T + C+ G++L G IC +W+G+ PSC+ S
Sbjct: 2777 CGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDH--NWSGQLPSCVPVS 2834
Query: 349 CG 350
CG
Sbjct: 2835 CG 2836
Score = 38.5 bits (88), Expect = 0.029
Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 6/78 (7%)
Query: 287 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGY--QLQGEETLIC-LNGTRPSWNGETP 343
++SCG P PA+G D G ++ C GY +L G C +NGT W+G P
Sbjct: 3130 IISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMP 3186
Query: 344 SCMASCGGTIHNATLGRI 361
+C A T + GR+
Sbjct: 3187 TCRAVTCPTPPQISNGRL 3204
Score = 35.8 bits (81), Expect = 0.19
Identities = 18/58 (31%), Positives = 24/58 (41%), Gaps = 2/58 (3%)
Query: 288 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 345
+SCG P P +G S + TF C+ GY +QG C W+ P C
Sbjct: 2833 VSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQC--QANRQWSHPPPMC 2888
Score = 35.0 bits (79), Expect = 0.32
Identities = 20/70 (28%), Positives = 29/70 (41%), Gaps = 4/70 (5%)
Query: 284 QAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGET 342
+ ++ CG P P + +S G T + C L G+ + C LNG W+G
Sbjct: 2949 ECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG---HWSGSQ 3005
Query: 343 PSCMASCGGT 352
P C GT
Sbjct: 3006 PHCSGDATGT 3015
Score = 34.3 bits (77), Expect = 0.54
Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 4/61 (6%)
Query: 289 SCGFPPRPAHGDVSVTDLHPGG-TATFHCDSGYQLQ-GEETLICLNGTRPSWNGETPSCM 346
SC P PAH +V DL G T + C G+ L G E +C + +W G+ P C
Sbjct: 3370 SCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDN--TWTGKVPICE 3427
Query: 347 A 347
A
Sbjct: 3428 A 3428
Score = 32.7 bits (73), Expect = 1.6
Identities = 20/73 (27%), Positives = 39/73 (53%), Gaps = 5/73 (6%)
Query: 830 VTQTTDPSRQLEGGN---LALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSP 886
+++ ++ S Q G N +A+AIL+P +I G G Y+Y + K+ ++G +
Sbjct: 3573 MSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKT--QYTGCSVHEN 3630
Query: 887 ITVESDFSNPLYE 899
++ F NP+Y+
Sbjct: 3631 NNGQAAFENPMYD 3643
Score = 31.6 bits (70), Expect = 3.5
Identities = 15/52 (28%), Positives = 27/52 (51%), Gaps = 7/52 (13%)
Query: 656 TASHGDLI------RGTVLTYQCEPGYELLG-SDILTCQWDLSWSAAPPACQ 700
T +H +++ G L Y C+PG+ L G ++ C+ D +W+ P C+
Sbjct: 3376 TPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICE 3427
Score = 31.2 bits (69), Expect = 4.6
Identities = 28/80 (35%), Positives = 35/80 (43%), Gaps = 11/80 (13%)
Query: 287 LLSCGFPPRPAHGDVSVTDLHPG---GTATFH-CDSGYQLQGEETLICL-NGTRPSWNGE 341
+++C P PA+ H GT F+ C+ GY L G LIC NG W+
Sbjct: 2890 VVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNG---QWDKP 2946
Query: 342 TPSC-MASCG--GTIHNATL 358
P C M CG G NA L
Sbjct: 2947 LPECIMIDCGHPGVPPNAVL 2966
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 224 bits (570), Expect = 4e-58
Identities = 181/670 (27%), Positives = 291/670 (43%), Gaps = 36/670 (5%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C +S+ G + SP +L DCT++I++ G+G+ +Q + + L +
Sbjct: 2111 CGGAMSDFSGVILSPGFPGNYPSSL---DCTWTINLPIGFGVHLQFVNFSTETIHDYLEV 2167
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGF 292
G S ++ S L S T+ L+F S GF I YQAY L
Sbjct: 2168 RSGSSE--TSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCP 2225
Query: 293 PPRP-AHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGG 351
PRP +G V D G T +F C GY L G L CL+G +WN P C A CGG
Sbjct: 2226 DPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGG 2285
Query: 352 TIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGS 411
I A G I SP C W++ G ++++F + + D + V G
Sbjct: 2286 NI-TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPD 2344
Query: 412 PLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPF-LA 470
SP I + E + S + + ++ S+ + + L + A++ C P +
Sbjct: 2345 QNSPQIGQFSGNTALE-SVYSTSNQILIKFHSDFTTSGFFV-LSYHAYQLRVCQPPPPVP 2402
Query: 471 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAI-ECVDPTEPHWNDTEPACKAMC-G 528
+ + T D E+ G + + CLPG+ L NAI C + P C+ +C
Sbjct: 2403 NAEILTEDDEFEIGDIIRYQCLPGFTLVG----NAILTCRLGERLQMDGAPPVCQVLCPA 2458
Query: 529 GELS-EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNV-REGDMLTLFDGD 586
EL + GV+LSP +P SY Q C W + V++ I + VE +E D+L ++DG
Sbjct: 2459 NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGP 2518
Query: 587 GPSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 645
+ VL L G + S+G ++ LQ+ A G G ++ + P +
Sbjct: 2519 NIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPES---- 2574
Query: 646 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDL----SWSAAPPACQK 701
PP + + G L +V+ + C+ G+ L+G C+ +W A PACQ
Sbjct: 2575 ---PPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQA 2629
Query: 702 IMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV 761
I +C P NG +D + VG+ V Y C GY L + T + GT ++
Sbjct: 2630 I-SCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKT 2686
Query: 762 PKCALKYEPCLNPGVPENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ 820
P+C + P +N + E+G ++ + HY+ + F C G+ +G +I C+P
Sbjct: 2687 PRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWS 2746
Query: 821 WTSQPPLCKV 830
W ++ P C++
Sbjct: 2747 WRNERPYCQI 2756
Score = 212 bits (540), Expect = 1e-54
Identities = 194/740 (26%), Positives = 292/740 (39%), Gaps = 79/740 (10%)
Query: 168 TSPVLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEE 227
T V C +++ +G + SP P L +C + I V G GI++QV +
Sbjct: 1934 TCIVPCGGILTKRKGTILSPGYPEPYDNNL---NCVWKITVPEGAGIQVQVVSFATEHNW 1990
Query: 228 ELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYL 287
+ L GG APRL + S +L S +N L L+FQS GF + Y A
Sbjct: 1991 DSLDFYDGGDNN-APRLGSYSGTTIP-HLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG 2048
Query: 288 L-SCGFPPRPAHGDVSVTDLHP-GGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 345
L SC P P+ G + + D + G +F CD GY LQG + C+ G WN P C
Sbjct: 2049 LDSCPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2107
Query: 346 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 405
+A CGG + + + G I+SP G +L C W I G +HL F S + +D L
Sbjct: 2108 LAQCGGAMSDFS-GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLE 2166
Query: 406 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 465
VRSG S S VI +P L S + S+ N + ++A++ C
Sbjct: 2167 VRSGSSETSTVIGRLSGPQIPS-SLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCP 2225
Query: 466 APF-LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 524
P +G V D + G +F C PGY L +A+ C+ +WN P C+
Sbjct: 2226 DPRPFRNGFVIGND--FTVGQTISFECFPGYTLIGN---SALTCLHGVSRNWNHPLPRCE 2280
Query: 525 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-GDMLTLF 583
A+CGG ++ G + SP +P Y QDC W V V I + +L D +T++
Sbjct: 2281 ALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVW 2340
Query: 584 DGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT 643
DG ++ + Q G + S+ + ++F + GF + +
Sbjct: 2341 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH------SDFTTSGFFVLSYHAYQLRV 2394
Query: 644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQ- 700
C PP + G ++ YQC PG+ L+G+ ILTC+ L APP CQ
Sbjct: 2395 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQV 2454
Query: 701 -------------------------KIMTCADPGEIANGHRTA-------SDAGFPV--- 725
+ CA + G+ ++ F V
Sbjct: 2455 LCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQV 2514
Query: 726 --GSHVQ----------YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLN 773
G ++Q Y + G + +S D G K R+ A C
Sbjct: 2515 YDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY---CST 2571
Query: 774 PGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS--QWTSQPPLCKVT 831
P P +GY + + Q +R+ C GF L+G+ + C W + P C+
Sbjct: 2572 PESPPHGY-IISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAI 2630
Query: 832 QTTDPSRQLEGGNLALAILL 851
P GG L L+
Sbjct: 2631 SCGIPKAPTNGGILTTDYLV 2650
Score = 207 bits (528), Expect = 3e-53
Identities = 186/714 (26%), Positives = 298/714 (41%), Gaps = 82/714 (11%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C + S G + SP +L +C + I PG+ I+I + ++L +
Sbjct: 895 CGGHFSAPSGVILSPGWPGYYKDSL---NCEWVIEAEPGHSIKITFERFQTELNYDVLEV 951
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL---S 289
G P L LL + + Q L S +N + L F + GF+IHY++ + S
Sbjct: 952 HDG--PNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYS 1009
Query: 290 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASC 349
C P P HG D G T +F CDSGY+L EE L+C W+ P+C A C
Sbjct: 1010 CLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHW--WSHPLPTCDALC 1067
Query: 350 GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSG 409
GG + + G I+SP +L C W ++ G+ + +F L++ +D L++
Sbjct: 1068 GGDVRGPS-GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITEN 1126
Query: 410 GSPLSPV--IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 467
GS P+ + SD+ GL + ++ + +S+ + ++ F + + C P
Sbjct: 1127 GSFTQPLARLTGSDLPPTINAGLYGNFRA-QLRFISDFSISYEGFNITFSEYNLEPCEDP 1185
Query: 468 FLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMC 527
+ + + G TFSC GY LE + I C+ W+ P C A C
Sbjct: 1186 GIPQYG-SRIGFNFGIGDTLTFSCSSGYRLEGT---SEIICLGGGRRVWSAPLPRCVAEC 1241
Query: 528 GGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDG 587
G + G++LSP++P +Y +C++ + VQ K I + ++ +GD+L ++DG
Sbjct: 1242 GASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKD 1301
Query: 588 PSARVLAQLRGPQPRRRLLSS-GPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPE 646
+ +L G R LSS L L+F + G +GF L + + C +
Sbjct: 1302 KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNS----DTEGTDEGFQLVYTSFELSH-CED 1356
Query: 647 LPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQKIMT 704
P++G++ + G G+ + Y C PGY L GS +L C +W P+C I
Sbjct: 1357 PGIPQFGYKISDQGH-FAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC--IAE 1413
Query: 705 CADPGEIANGHRTASDAGFPVGSHVQYRCL------PG--YSLEGAAMLTCYSRDT---- 752
C + + R S G+P RC+ PG SL+ A T S D
Sbjct: 1414 CGGRFKGESSGRILS-PGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVW 1472
Query: 753 GTPKWSDRVPK--------------------------------CALKYE-----PCLNPG 775
P +D + K A+++ C +PG
Sbjct: 1473 DGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPG 1532
Query: 776 VPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ-WTSQPPLC 828
VP NG T + G+++ F C G+EL GE ITC+ W PP+C
Sbjct: 1533 VPMNG--TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1584
Score = 206 bits (524), Expect = 8e-53
Identities = 190/781 (24%), Positives = 318/781 (40%), Gaps = 96/781 (12%)
Query: 179 EGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSP 238
E G + SP P L C + I V PG + +Q + ++L + G
Sbjct: 1421 ESSGRILSPGYPFPYDNNLR---CMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPE 1477
Query: 239 GLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CGFPPRPA 297
+ S++ EG + S N + + F + GF I + + + + C P P
Sbjct: 1478 NDMLLKEISGSLIPEG--IHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPM 1535
Query: 298 HGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGETPSCMASCGGTIHNA 356
+G + PG T F CD GY+LQGEE + C+ R W P C+A CGG + +
Sbjct: 1536 NGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGS 1595
Query: 357 TLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPV 416
+ G I+SP + C W I + L F S++ + D L + G SP+
Sbjct: 1596 S-GFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPL 1654
Query: 417 IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV-- 474
I +PER + S + ++++ S+ + L ++A + CF P GN+
Sbjct: 1655 IGSFQDSKLPER-IESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP----GNIMN 1709
Query: 475 -TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHWNDTEPACKAMCGGEL 531
T +Y+ G+ T+ C GY L+ + + C+ D P WN P+C A CG
Sbjct: 1710 GTRLGMDYKLGSTVTYYCDAGYVLQGY---STLTCIMGDDGRPGWNRALPSCHAPCGSRS 1766
Query: 532 SEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSAR 591
+ G VLSP++P++YS G +CV+ + V +E + Q D++ ++DG +
Sbjct: 1767 TGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSS 1826
Query: 592 VLAQLRGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT--CPELP 648
+L+ L G L LSSG +T++F + P +GF ++ VPR + C +P
Sbjct: 1827 LLSSLSGSHSGESLPLSSGNQITIRFTS----VGPITAKGFHFVYQAVPRTSSTQCSSVP 1882
Query: 649 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC--------QWDLSWSAAPPACQ 700
P +G R + + G+ + + C PGY L GS + C QW+ S C
Sbjct: 1883 EPRFGRRIGN--EFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG 1940
Query: 701 KIMTCADPGEIANGHRTASDAGF--------PVGSHVQYRCLPGYSLE------------ 740
I+T ++ G+ D P G+ +Q + + ++ E
Sbjct: 1941 GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVV-SFATEHNWDSLDFYDGG 1999
Query: 741 --GAAMLTCYS--------------------RDTGTPKWSDRVPKCALKYEPCLNPGVPE 778
A L YS D + A+ + C P P
Sbjct: 2000 DNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPS 2059
Query: 779 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSR 838
+G + Y G+ + F C +G+ L G ITC+PG +W P+C + Q
Sbjct: 2060 SGIK--IGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC-LAQCGGAMS 2116
Query: 839 QLEG--------GNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGF----SGSHSYSP 886
G GN ++ + + +G GV++ + +++ + SGS S
Sbjct: 2117 DFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETST 2176
Query: 887 I 887
+
Sbjct: 2177 V 2177
Score = 182 bits (463), Expect = 9e-46
Identities = 154/570 (27%), Positives = 238/570 (41%), Gaps = 29/570 (5%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C + + EG + SP+ +C YSI V G GI I +T +L+Q + L +
Sbjct: 1241 CGASATNNEGILLSPNYPLNYENNH---ECIYSIQVQAGKGINISARTFHLAQGDVLKIY 1297
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CG 291
G +SM G L S +N+L L F S GF++ Y ++ LS C
Sbjct: 1298 DGKDKTTHLLGAFTGASM--RGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCE 1355
Query: 292 FPPRPAHG-DVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 350
P P G +S G T + C+ GY L G L C+ G R +W+ PSC+A CG
Sbjct: 1356 DPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECG 1415
Query: 351 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 410
G + GRI+SP NL C W+IE G + L F + +D L V G
Sbjct: 1416 GRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGP 1475
Query: 411 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 470
++ + +PE G+ S + ++ ++ + +++F + C P +
Sbjct: 1476 PENDMLLKEISGSLIPE-GIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVP 1534
Query: 471 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH-WNDTEPACKAMCGG 529
N T PG F C PGY L+ I C+ + W + P C A CGG
Sbjct: 1535 M-NGTRNGDGREPGDTVVFQCDPGYELQ---GEERITCIQVENRYFWQPSPPVCIAPCGG 1590
Query: 530 ELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDGDGP 588
L+ +G +LSP++P Y +DC W + V + I L ++ D L ++DG
Sbjct: 1591 NLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDS 1650
Query: 589 SARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELP 648
++ ++ + + R+ SS + L F++ GF L +K R ++C
Sbjct: 1651 NSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSY----TGFHLEYKAKLR-ESC--FD 1703
Query: 649 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPACQKIMT 704
P T D G+ +TY C+ GY L G LTC W+ A P+C
Sbjct: 1704 PGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH--AP 1761
Query: 705 CADPGEIANGHRTASDAGFPVGSHVQYRCL 734
C + G T +P V + C+
Sbjct: 1762 CGSRSTGSEG--TVLSPNYPKNYSVGHNCV 1789
Score = 171 bits (432), Expect = 4e-42
Identities = 193/787 (24%), Positives = 301/787 (38%), Gaps = 119/787 (15%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C N++ G++ SP+ P + DC ++I V Y I + + ++ + L +
Sbjct: 1588 CGGNLTGSSGFILSPNFPHPYPHSR---DCDWTITVNADYVISLAFISFSIEPNYDFLYI 1644
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSP------TNRLLLHFQSPRVPRGGGFRIHYQAY 286
G +NS ++G Q + P +N + L F+S GF + Y+A
Sbjct: 1645 YDGPD--------SNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK 1696
Query: 287 LL-SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETP 343
L SC P +G D G T T++CD+GY LQG TL C+ G RP WN P
Sbjct: 1697 LRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1756
Query: 344 SCMASCGGTIHNATLGRIVSPE--PGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN 401
SC A CG + G ++SP +VG N + F + SL +
Sbjct: 1757 SCHAPCGSR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL---H 1812
Query: 402 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAF-- 459
D + V G + S ++ E +S + + S P ++A
Sbjct: 1813 DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPR 1872
Query: 460 -EEDRCFA-PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIEC--VDPTEPH 515
+C + P G E+ G+ F C PGY L AI C V +
Sbjct: 1873 TSSTQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGYILHGS---IAIRCETVPNSLAQ 1927
Query: 516 WNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQV-EILNV 574
WND+ P C CGG L++ G +LSP +P+ Y +CVW + V E I +QV
Sbjct: 1928 WNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATE 1987
Query: 575 REGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLH 634
D L +DG +A L G L S+ +L L FQ+ GF L
Sbjct: 1988 HNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVS----AAGFHLE 2043
Query: 635 FKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSW 692
+ + D+CPE P G + + G V+++QC+ GY L G +TC W
Sbjct: 2044 YTAIGL-DSCPEPQTPSSGIKIGDR--YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRW 2100
Query: 693 SAAPPACQK------------IMTCADPGEIANGHRTASDAGFPVGS--HVQYRCLPGYS 738
+ P C I++ PG + P+G H+Q+ +
Sbjct: 2101 NYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET 2160
Query: 739 LEGAAMLTCYSRDTGTP-------------------------------KWSDRVPKCALK 767
+ + S +T T K + A +
Sbjct: 2161 IHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQ 2220
Query: 768 YEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 827
+ C +P NG+ + + + G+++ F C+ G+ LIG +TC+ G W P
Sbjct: 2221 LQSCPDPRPFRNGF--VIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPR 2278
Query: 828 CKVTQTTDPSRQLEGGNLAL---AILLP------------LGLV-IVLGSGVYIYYTKLQ 871
C+ L GGN+ I P LV + G+G+YI +T LQ
Sbjct: 2279 CEA---------LCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQ 2329
Query: 872 GKSLFGF 878
+ ++ F
Sbjct: 2330 TEPIYDF 2336
Score = 167 bits (422), Expect = 5e-41
Identities = 138/556 (24%), Positives = 231/556 (41%), Gaps = 23/556 (4%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIH-VYPGYGIEIQVQTLNLSQEEELLV 231
C +N+ G SP+ C + I V I+I + +L + L
Sbjct: 548 CGSNLQGPSGTFTSPNFPFQYDSNA---QCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 604
Query: 232 LAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-SC 290
+ GG G +L + ++ S ++++ LH Q+ GF+++Y+ SC
Sbjct: 605 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 664
Query: 291 GFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 350
G P P +G F C G++L GE++++C + W+ P C+ C
Sbjct: 665 GDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ--WSANIPICIFPCL 722
Query: 351 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 410
A +G ++SP+ G NL C W I + G R+HL F L+ D L V+ G
Sbjct: 723 SNF-TAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD 781
Query: 411 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 470
SP SP++ +VP L S++ L +E ++ + ++ + F + C P +
Sbjct: 782 SPESPILGTFTGAEVPSH-LTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP 840
Query: 471 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGE 530
N ++ G+ + C G+ ++ G + + W+ P C A CGG
Sbjct: 841 I-NARRFGDNFQLGSSISVICEEGF-IKTQGTETITCILMDGKVMWSGLIPKCGAPCGGH 898
Query: 531 LSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDGPS 589
S P+GV+LSP WP Y +C W + + I + E D+L + DG
Sbjct: 899 FSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLL 958
Query: 590 ARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRND-TCPELP 648
+ +L G Q + L SS + L F N GF +H++ V N +C +
Sbjct: 959 SPLLGSYNGTQVPQFLFSSSNFIYLLFTT----DNSRSNNGFKIHYESVTVNTYSCLDPG 1014
Query: 649 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADP 708
P G R D G+ +++ C+ GY L + L C+ + WS P C + C
Sbjct: 1015 IPVHGRRYGH--DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL--CG-- 1068
Query: 709 GEIANGHRTASDAGFP 724
G++ T G+P
Sbjct: 1069 GDVRGPSGTILSPGYP 1084
Score = 122 bits (307), Expect = 1e-27
Identities = 105/424 (24%), Positives = 179/424 (42%), Gaps = 32/424 (7%)
Query: 290 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSC-M 346
C P P +G +D G T F CD Y LQG +++ C + +W+ P C +
Sbjct: 486 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKV 545
Query: 347 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRR-LHLHFERVSLDEDNDRLM 405
+CG + + G SP N C WVI A + + ++FE L+ D L
Sbjct: 546 KTCGSNLQGPS-GTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 604
Query: 406 VRSGGSPLSP-----VIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFE 460
+ GG P V+ S + D+ ++S + +++ L ++ + + ++ E
Sbjct: 605 IGDGGEVGDPRTVLQVLTGSFVPDL----IVSMSSQMWLHLQTDESVGSVGFKVNYKEIE 660
Query: 461 EDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 520
++ C P + D + + F C G+ L +I C + + W+
Sbjct: 661 KESCGDPGTPLYGIREGD-GFSNRDVLRFECQFGFELI---GEKSIVCQENNQ--WSANI 714
Query: 521 PACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDM 579
P C C + P G VLSPD+P+ Y +C+W + RI L ++ + D
Sbjct: 715 PICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDF 774
Query: 580 LTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVP 639
L + DGD P + +L G + L S+ L L+FQA + G+GF + +
Sbjct: 775 LAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQA----DHSMSGRGFNITYNTFG 830
Query: 640 RNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGY-ELLGSDILTC---QWDLSWSAA 695
N+ CP+ P R + L G+ ++ CE G+ + G++ +TC + WS
Sbjct: 831 HNE-CPDPGIPINARRFGDNFQL--GSSISVICEEGFIKTQGTETITCILMDGKVMWSGL 887
Query: 696 PPAC 699
P C
Sbjct: 888 IPKC 891
Score = 89.0 bits (219), Expect = 2e-17
Identities = 62/203 (30%), Positives = 85/203 (41%), Gaps = 12/203 (5%)
Query: 641 NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 700
N + P +P HG+ GTV+ Y C PGY L GS +L CQ + W P C
Sbjct: 2932 NCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2991
Query: 701 KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 760
I C PG N S + GS V Y C SL G + TC WS
Sbjct: 2992 MI-DCGHPGVPPNA--VLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG----HWSGS 3044
Query: 761 VPKCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS 819
P C+ C +PG P G+ + + +++ ++R+ C G+ L G TC+
Sbjct: 3045 QPHCSGDATGTCGDPGTP--GHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLAN--G 3100
Query: 820 QWTSQPPLCKVTQTTDPSRQLEG 842
WT + P CK Q +P G
Sbjct: 3101 SWTGRQPECKAVQCGNPGTTANG 3123
Score = 85.9 bits (211), Expect = 2e-16
Identities = 63/195 (32%), Positives = 89/195 (45%), Gaps = 21/195 (10%)
Query: 656 TASHGDLIR--GTVLT----YQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPG 709
T ++G + R GT + Y C GY L G + C + +WS P C I++C DPG
Sbjct: 3119 TTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNC-TIISCGDPG 3177
Query: 710 EIANGHRTASDAGFPVGSHVQYRCLPGYSLE--GAAMLTCYSRDTGTPKWSDRVPKCALK 767
ANG R D + VG +V Y C PGY++E G+ + TC T WS +P C +
Sbjct: 3178 IPANGLRYGDD--YVVGQNVSYMCQPGYTMELNGSRIRTCTINGT----WSGVMPTC--R 3229
Query: 768 YEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 827
C P NG L ++ G S+ + C G+EL +TCV W+ + P
Sbjct: 3230 AVTCPTPPQISNG--RLEGTNFDWGFSISYICSPGYELSFPAVLTCVGN--GTWSGEVPQ 3285
Query: 828 CKVTQTTDPSRQLEG 842
C DP +G
Sbjct: 3286 CLPKFCGDPGIPAQG 3300
Score = 83.2 bits (204), Expect = 1e-15
Identities = 62/187 (33%), Positives = 82/187 (43%), Gaps = 13/187 (6%)
Query: 643 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 702
TCP P G ++ D G ++Y C PGYEL +LTC + +WS P C
Sbjct: 3232 TCPTPPQISNGRLEGTNFDW--GFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP- 3288
Query: 703 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 762
C DPG A G R F S V + C + L G++ C + T WS P
Sbjct: 3289 KFCGDPGIPAQGKREGK--SFIYQSEVSFSCNFPFILVGSSTRICQADGT----WSGSSP 3342
Query: 763 KCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 821
C + C NPGVP +G Q +Q G ++F C +G L G T TC+P W
Sbjct: 3343 HCIEPTQTSCENPGVPRHGSQN-NTFGFQVGSVVQFHCKKGHLLQGSTTRTCLP--DLTW 3399
Query: 822 TSQPPLC 828
+ P C
Sbjct: 3400 SGIQPEC 3406
Score = 82.4 bits (202), Expect = 2e-15
Identities = 53/167 (31%), Positives = 74/167 (44%), Gaps = 14/167 (8%)
Query: 664 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF 723
R TV+ YQC PG+ L+GS + CQ D +WS P+C + +C PG G S GF
Sbjct: 2836 RDTVV-YQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV-SCGHPGSPIYGR--TSGNGF 2891
Query: 724 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT 783
V + C GY ++G C + +WS P C K C +PG+P N +
Sbjct: 2892 NFNDVVTFSCNIGYLMQGPTKAQCQA----NRQWSHPPPMC--KVVNCSDPGIPANSKRE 2945
Query: 784 LYKHH--YQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 828
H + G + + C G+ L G + C P QW P C
Sbjct: 2946 SKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN--GQWDKPLPEC 2990
Score = 73.6 bits (179), Expect = 8e-13
Identities = 63/245 (25%), Positives = 97/245 (39%), Gaps = 37/245 (15%)
Query: 643 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 702
+C ELP P G + + G+ + C+ G+ L+GS + C WS + C
Sbjct: 2758 SCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLA- 2814
Query: 703 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 762
C P I NG + G+ V Y+C PG+ L G+++ C WS ++P
Sbjct: 2815 GHCGIPELIVNGQVIGENYGYR--DTVVYQCNPGFRLIGSSVRICQQDHN----WSGQLP 2868
Query: 763 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 822
C C +PG P G + + + + + F C G+ + G C QW+
Sbjct: 2869 SCVPV--SCGHPGSPIYGRTS--GNGFNFNDVVTFSCNIGYLMQGPTKAQCQANR--QWS 2922
Query: 823 SQPPLCKVTQTTDP--------SRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKS 874
PP+CKV +DP ++E GN G ++Y G
Sbjct: 2923 HPPPMCKVVNCSDPGIPANSKRESKIEHGNFTY--------------GTVVFYDCNPGYF 2968
Query: 875 LFGFS 879
LFG S
Sbjct: 2969 LFGSS 2973
Score = 69.7 bits (169), Expect = 1e-11
Identities = 76/278 (27%), Positives = 113/278 (40%), Gaps = 16/278 (5%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C + G +ESP G P G +CT+ I I+I Q+ L +E + L L
Sbjct: 65 CGGTLKGLNGTIESP--GFPYGYPNGA-NCTWVIIAEERNRIQIVFQSFALEEEYDYLSL 121
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CG 291
G R L + S + L S GF+++Y+ S CG
Sbjct: 122 YDGHPHPTNFRTRLTGFHLPPP--VTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 179
Query: 292 FPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETPSCMA-- 347
P P G + T G + C +GY L G L C+ + SW+ P C A
Sbjct: 180 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 239
Query: 348 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 407
+CGGT+ ++ G I SP N C W I A G + L F ++E D L +
Sbjct: 240 ACGGTMRGSS-GIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI- 297
Query: 408 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSET 445
G P P I+ S M+ P +IS+ L + ++++
Sbjct: 298 EGSEP--PTIWLSGMNIPPP--IISNKNWLRLHFVTDS 331
Score = 68.6 bits (166), Expect = 3e-11
Identities = 64/269 (23%), Positives = 108/269 (40%), Gaps = 16/269 (5%)
Query: 342 TPSCMA----SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSL 397
T SC+ +CGGT+ G I SP C WVI A E R+ + F+ +L
Sbjct: 54 TVSCVKGFIYTCGGTLKGLN-GTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFAL 112
Query: 398 DEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-VELLSETPANPLLLSLRF 456
+E+ D L + G P + + + ++ +S++ + L S+ + + +
Sbjct: 113 EEEYDYLSLYDGHP--HPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 170
Query: 457 EAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEP 514
E + C P + V + G +SC+ GY L+ G P + C+
Sbjct: 171 EELQSSSCGNPGVPPKGVLY-GTRFDVGDKIRYSCVTGYILD--GHPQ-LTCIANSVNTA 226
Query: 515 HWNDTEPACKA--MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEIL 572
W+ P C+A CGG + +G++ SP +P Y DC W + + I L
Sbjct: 227 SWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDF 286
Query: 573 NVREGDMLTLFDGDGPSARVLAQLRGPQP 601
+ E +G P L+ + P P
Sbjct: 287 QMEEKYDYLEIEGSEPPTIWLSGMNIPPP 315
Score = 57.4 bits (137), Expect = 6e-08
Identities = 95/374 (25%), Positives = 147/374 (39%), Gaps = 72/374 (19%)
Query: 171 VLC--NNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEE 228
VLC N + G + SP G P S L C +SI V GY I + V+ +E +
Sbjct: 2454 VLCPANELRLDSTGVILSP--GYPDSYP-NLQMCAWSISVEKGYNITMFVEFFQTEKEFD 2510
Query: 229 LLVLAGGGSPGL-APRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYL 287
+L + G P + +P L++ S + S + + L + + GFRI Y A+
Sbjct: 2511 VLQVYDG--PNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY 2568
Query: 288 LSCGFPPRPAHGDV-SVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRP--SWNGETPS 344
C P P HG + S T + CD G++L G+ + +C + +W+ P+
Sbjct: 2569 --CSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPA 2626
Query: 345 CMA-SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDR 403
C A SC G +P GG LT +++ G R+ D R
Sbjct: 2627 CQAISC---------GIPKAPTNGGI----LTTDYLV----GTRV------TYFCNDGYR 2663
Query: 404 LMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDR 463
L + L+ + SD G S+ ++TP ++ +F
Sbjct: 2664 LSSKE----LTTAVCQSD-------GTWSNH--------NKTPRCVVVTCPSINSF---- 2700
Query: 464 CFAPFLAHGN---VTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 520
L HG V + EY+ + FSC PGY P +IEC+ W +
Sbjct: 2701 ----ILEHGRWRIVNGSHYEYKTKVV--FSCDPGYHGLGPA---SIECLPNGTWSWRNER 2751
Query: 521 PACKAMCGGELSEP 534
P C+ + GEL P
Sbjct: 2752 PYCQIISCGELPTP 2765
Score = 57.0 bits (136), Expect = 8e-08
Identities = 53/212 (25%), Positives = 83/212 (39%), Gaps = 14/212 (6%)
Query: 527 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDG 585
CGG L G + SP +P Y G +C W + +E RI + + + E D L+L+DG
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDG 124
Query: 586 DGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 645
+L G + S+ +L+ + GF ++++E+ ++ +C
Sbjct: 125 HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVS----AHGFKVYYEEL-QSSSCG 179
Query: 646 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD----LSWSAAPPACQK 701
P G + D+ G + Y C GY L G LTC + SW P C+
Sbjct: 180 NPGVPPKGVLYGTRFDV--GDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237
Query: 702 IMTCADPGEIANGHRTASDAGFPVGSHVQYRC 733
C G + S FP H C
Sbjct: 238 EDACG--GTMRGSSGIISSPSFPNEYHNNADC 267
Score = 53.5 bits (127), Expect = 9e-07
Identities = 44/136 (32%), Positives = 57/136 (41%), Gaps = 13/136 (9%)
Query: 236 GSPGLAPRLLANSSMLGEGQVLR-SPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-----S 289
G PG+ P + + G + S T + L QS R + G Q + +
Sbjct: 2996 GHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGT 3055
Query: 290 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMA- 347
CG P P HG ++ T + CD+GY L G E CL NG SW G P C A
Sbjct: 3056 CGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANG---SWTGRQPECKAV 3112
Query: 348 SCG--GTIHNATLGRI 361
CG GT N + RI
Sbjct: 3113 QCGNPGTTANGKVFRI 3128
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/63 (44%), Positives = 33/63 (52%), Gaps = 2/63 (3%)
Query: 705 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 764
C DPGE NG R SD F +GS VQ+ C Y L+GA +TC WSD P C
Sbjct: 486 CPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 543
Query: 765 ALK 767
+K
Sbjct: 544 KVK 546
Score = 52.0 bits (123), Expect = 3e-06
Identities = 40/130 (30%), Positives = 59/130 (45%), Gaps = 14/130 (10%)
Query: 639 PRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPA 698
P +C P G + + G + G+V+ + C+ G+ L GS TC DL+WS P
Sbjct: 3347 PTQTSCENPGVPRHGSQNNTFGFQV-GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPE 3405
Query: 699 CQKIMTCADPGEIANGHRTASDAGFPVGSH---VQYRCLPGYSLEGAA-MLTCYSRDTGT 754
C +C P A+ A+ G + SH + Y C PG+ L G C S +T
Sbjct: 3406 CIP-HSCKQPETPAH----ANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNT-- 3458
Query: 755 PKWSDRVPKC 764
W+ +VP C
Sbjct: 3459 --WTGKVPIC 3466
Score = 48.5 bits (114), Expect = 3e-05
Identities = 45/187 (24%), Positives = 71/187 (37%), Gaps = 18/187 (9%)
Query: 705 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC 764
C+ P +G+ S G + S V++ C G+ L G + C G W VP C
Sbjct: 2569 CSTPESPPHGY-IISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC 2627
Query: 765 ALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQ 824
+ C P P NG + Y G + +FC +G+ L + T V W++
Sbjct: 2628 --QAISCGIPKAPTNG--GILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNH 2683
Query: 825 PPLCKVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS-GSHS 883
+ T PS + +L G ++ Y Y TK+ +F G H
Sbjct: 2684 NKTPRCVVVTCPSIN--------SFILEHGRWRIVNGSHYEYKTKV----VFSCDPGYHG 2731
Query: 884 YSPITVE 890
P ++E
Sbjct: 2732 LGPASIE 2738
Score = 44.3 bits (103), Expect = 5e-04
Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 4/66 (6%)
Query: 766 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPG--HPSQWTS 823
L+ C NPGVP G LY + G+ +R+ C G+ L G +TC+ + + W
Sbjct: 173 LQSSSCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 230
Query: 824 QPPLCK 829
P+C+
Sbjct: 231 PVPICR 236
Score = 44.3 bits (103), Expect = 5e-04
Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 2/61 (3%)
Query: 704 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 763
+C +PG G F VG ++Y C+ GY L+G LTC + T W VP
Sbjct: 177 SCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPI 234
Query: 764 C 764
C
Sbjct: 235 C 235
Score = 42.0 bits (97), Expect = 0.003
Identities = 22/65 (33%), Positives = 36/65 (55%), Gaps = 5/65 (7%)
Query: 288 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCM 346
++C PP+ ++G + T+ G + ++ C GY+L L C+ NGT W+GE P C+
Sbjct: 3231 VTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCL 3287
Query: 347 AS-CG 350
CG
Sbjct: 3288 PKFCG 3292
Score = 41.2 bits (95), Expect = 0.004
Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 4/63 (6%)
Query: 766 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQP 825
++ E C +PG P G + + + LRF C GFELIGE +I C +QW++
Sbjct: 659 IEKESCGDPGTPLYGIRE--GDGFSNRDVLRFECQFGFELIGEKSIVCQEN--NQWSANI 714
Query: 826 PLC 828
P+C
Sbjct: 715 PIC 717
Score = 41.2 bits (95), Expect = 0.004
Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 2/81 (2%)
Query: 287 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 346
++SCG P P +G+ T G TA F CD G+ L G CL+ W+ C+
Sbjct: 2756 IISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSS--GLWSESETRCL 2813
Query: 347 ASCGGTIHNATLGRIVSPEPG 367
A G G+++ G
Sbjct: 2814 AGHCGIPELIVNGQVIGENYG 2834
Score = 40.4 bits (93), Expect = 0.008
Identities = 39/148 (26%), Positives = 55/148 (37%), Gaps = 27/148 (18%)
Query: 769 EPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ--WTSQPP 826
E C +PG NG T Y+ G ++ ++C G+ L G T+TC+ G + W P
Sbjct: 1699 ESCFDPGNIMNG--TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1756
Query: 827 LC-------------KVTQTTDPSRQLEGGNLALAILLPLGLVIV---------LGSGVY 864
C V P G N +I +P V+ L V
Sbjct: 1757 SCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVE 1816
Query: 865 IYYTKLQGKSLF-GFSGSHSYSPITVES 891
+Y Q SL SGSHS + + S
Sbjct: 1817 VYDGPTQQSSLLSSLSGSHSGESLPLSS 1844
Score = 40.4 bits (93), Expect = 0.008
Identities = 22/59 (37%), Positives = 27/59 (45%), Gaps = 3/59 (5%)
Query: 289 SCGFPPRPAHGDVSVT-DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 346
SC P P HG + T G FHC G+ LQG T CL +W+G P C+
Sbjct: 3351 SCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDL--TWSGIQPECI 3407
Score = 38.5 bits (88), Expect = 0.029
Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 4/62 (6%)
Query: 771 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQWTSQPPLC 828
C +PG PENG + + G +++F C E + L G +ITC + + W+ P+C
Sbjct: 486 CPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 543
Query: 829 KV 830
KV
Sbjct: 544 KV 545
Score = 38.5 bits (88), Expect = 0.029
Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 3/62 (4%)
Query: 290 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-AS 348
CG P +G V + T + C+ G++L G IC +W+G+ PSC+ S
Sbjct: 2817 CGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDH--NWSGQLPSCVPVS 2874
Query: 349 CG 350
CG
Sbjct: 2875 CG 2876
Score = 38.5 bits (88), Expect = 0.029
Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 6/78 (7%)
Query: 287 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGY--QLQGEETLIC-LNGTRPSWNGETP 343
++SCG P PA+G D G ++ C GY +L G C +NGT W+G P
Sbjct: 3170 IISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMP 3226
Query: 344 SCMASCGGTIHNATLGRI 361
+C A T + GR+
Sbjct: 3227 TCRAVTCPTPPQISNGRL 3244
Score = 35.8 bits (81), Expect = 0.19
Identities = 18/58 (31%), Positives = 24/58 (41%), Gaps = 2/58 (3%)
Query: 288 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 345
+SCG P P +G S + TF C+ GY +QG C W+ P C
Sbjct: 2873 VSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQC--QANRQWSHPPPMC 2928
Score = 35.0 bits (79), Expect = 0.32
Identities = 20/70 (28%), Positives = 29/70 (41%), Gaps = 4/70 (5%)
Query: 284 QAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGET 342
+ ++ CG P P + +S G T + C L G+ + C LNG W+G
Sbjct: 2989 ECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG---HWSGSQ 3045
Query: 343 PSCMASCGGT 352
P C GT
Sbjct: 3046 PHCSGDATGT 3055
Score = 34.3 bits (77), Expect = 0.54
Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 4/61 (6%)
Query: 289 SCGFPPRPAHGDVSVTDLHPGG-TATFHCDSGYQLQ-GEETLICLNGTRPSWNGETPSCM 346
SC P PAH +V DL G T + C G+ L G E +C + +W G+ P C
Sbjct: 3410 SCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDN--TWTGKVPICE 3467
Query: 347 A 347
A
Sbjct: 3468 A 3468
Score = 32.7 bits (73), Expect = 1.6
Identities = 20/73 (27%), Positives = 39/73 (53%), Gaps = 5/73 (6%)
Query: 830 VTQTTDPSRQLEGGN---LALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSP 886
+++ ++ S Q G N +A+AIL+P +I G G Y+Y + K+ ++G +
Sbjct: 3613 MSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKT--QYTGCSVHEN 3670
Query: 887 ITVESDFSNPLYE 899
++ F NP+Y+
Sbjct: 3671 NNGQAAFENPMYD 3683
Score = 31.6 bits (70), Expect = 3.5
Identities = 15/52 (28%), Positives = 27/52 (51%), Gaps = 7/52 (13%)
Query: 656 TASHGDLI------RGTVLTYQCEPGYELLG-SDILTCQWDLSWSAAPPACQ 700
T +H +++ G L Y C+PG+ L G ++ C+ D +W+ P C+
Sbjct: 3416 TPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICE 3467
Score = 31.2 bits (69), Expect = 4.6
Identities = 28/80 (35%), Positives = 35/80 (43%), Gaps = 11/80 (13%)
Query: 287 LLSCGFPPRPAHGDVSVTDLHPG---GTATFH-CDSGYQLQGEETLICL-NGTRPSWNGE 341
+++C P PA+ H GT F+ C+ GY L G LIC NG W+
Sbjct: 2930 VVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNG---QWDKP 2986
Query: 342 TPSC-MASCG--GTIHNATL 358
P C M CG G NA L
Sbjct: 2987 LPECIMIDCGHPGVPPNAVL 3006
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 212 bits (540), Expect = 1e-54
Identities = 194/740 (26%), Positives = 292/740 (39%), Gaps = 79/740 (10%)
Query: 168 TSPVLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEE 227
T V C +++ +G + SP P L +C + I V G GI++QV +
Sbjct: 1830 TCIVPCGGILTKRKGTILSPGYPEPYDNNL---NCVWKITVPEGAGIQVQVVSFATEHNW 1886
Query: 228 ELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYL 287
+ L GG APRL + S +L S +N L L+FQS GF + Y A
Sbjct: 1887 DSLDFYDGGDNN-APRLGSYSGTTIP-HLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG 1944
Query: 288 L-SCGFPPRPAHGDVSVTDLHP-GGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 345
L SC P P+ G + + D + G +F CD GY LQG + C+ G WN P C
Sbjct: 1945 LDSCPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2003
Query: 346 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLM 405
+A CGG + + + G I+SP G +L C W I G +HL F S + +D L
Sbjct: 2004 LAQCGGAMSDFS-GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLE 2062
Query: 406 VRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCF 465
VRSG S S VI +P L S + S+ N + ++A++ C
Sbjct: 2063 VRSGSSETSTVIGRLSGPQIPS-SLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCP 2121
Query: 466 APF-LAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACK 524
P +G V D + G +F C PGY L +A+ C+ +WN P C+
Sbjct: 2122 DPRPFRNGFVIGND--FTVGQTISFECFPGYTLIGN---SALTCLHGVSRNWNHPLPRCE 2176
Query: 525 AMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-GDMLTLF 583
A+CGG ++ G + SP +P Y QDC W V V I + +L D +T++
Sbjct: 2177 ALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVW 2236
Query: 584 DGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT 643
DG ++ + Q G + S+ + ++F + GF + +
Sbjct: 2237 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFH------SDFTTSGFFVLSYHAYQLRV 2290
Query: 644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQ- 700
C PP + G ++ YQC PG+ L+G+ ILTC+ L APP CQ
Sbjct: 2291 CQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQV 2350
Query: 701 -------------------------KIMTCADPGEIANGHRTA-------SDAGFPV--- 725
+ CA + G+ ++ F V
Sbjct: 2351 LCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQV 2410
Query: 726 --GSHVQ----------YRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLN 773
G ++Q Y + G + +S D G K R+ A C
Sbjct: 2411 YDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFY---CST 2467
Query: 774 PGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS--QWTSQPPLCKVT 831
P P +GY + + Q +R+ C GF L+G+ + C W + P C+
Sbjct: 2468 PESPPHGY-IISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAI 2526
Query: 832 QTTDPSRQLEGGNLALAILL 851
P GG L L+
Sbjct: 2527 SCGIPKAPTNGGILTTDYLV 2546
Score = 207 bits (528), Expect = 3e-53
Identities = 186/714 (26%), Positives = 298/714 (41%), Gaps = 82/714 (11%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C + S G + SP +L +C + I PG+ I+I + ++L +
Sbjct: 791 CGGHFSAPSGVILSPGWPGYYKDSL---NCEWVIEAEPGHSIKITFERFQTELNYDVLEV 847
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL---S 289
G P L LL + + Q L S +N + L F + GF+IHY++ + S
Sbjct: 848 HDG--PNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYS 905
Query: 290 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASC 349
C P P HG D G T +F CDSGY+L EE L+C W+ P+C A C
Sbjct: 906 CLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHW--WSHPLPTCDALC 963
Query: 350 GGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSG 409
GG + + G I+SP +L C W ++ G+ + +F L++ +D L++
Sbjct: 964 GGDVRGPS-GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITEN 1022
Query: 410 GSPLSPV--IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 467
GS P+ + SD+ GL + ++ + +S+ + ++ F + + C P
Sbjct: 1023 GSFTQPLARLTGSDLPPTINAGLYGNFRA-QLRFISDFSISYEGFNITFSEYNLEPCEDP 1081
Query: 468 FLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMC 527
+ + + G TFSC GY LE + I C+ W+ P C A C
Sbjct: 1082 GIPQYG-SRIGFNFGIGDTLTFSCSSGYRLEGT---SEIICLGGGRRVWSAPLPRCVAEC 1137
Query: 528 GGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDG 587
G + G++LSP++P +Y +C++ + VQ K I + ++ +GD+L ++DG
Sbjct: 1138 GASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKD 1197
Query: 588 PSARVLAQLRGPQPRRRLLSS-GPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPE 646
+ +L G R LSS L L+F + G +GF L + + C +
Sbjct: 1198 KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNS----DTEGTDEGFQLVYTSFELSH-CED 1252
Query: 647 LPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSWSAAPPACQKIMT 704
P++G++ + G G+ + Y C PGY L GS +L C +W P+C I
Sbjct: 1253 PGIPQFGYKISDQGH-FAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSC--IAE 1309
Query: 705 CADPGEIANGHRTASDAGFPVGSHVQYRCL------PG--YSLEGAAMLTCYSRDT---- 752
C + + R S G+P RC+ PG SL+ A T S D
Sbjct: 1310 CGGRFKGESSGRILS-PGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVW 1368
Query: 753 GTPKWSDRVPK--------------------------------CALKYE-----PCLNPG 775
P +D + K A+++ C +PG
Sbjct: 1369 DGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPG 1428
Query: 776 VPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ-WTSQPPLC 828
VP NG T + G+++ F C G+EL GE ITC+ W PP+C
Sbjct: 1429 VPMNG--TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1480
Score = 206 bits (524), Expect = 8e-53
Identities = 190/781 (24%), Positives = 318/781 (40%), Gaps = 96/781 (12%)
Query: 179 EGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSP 238
E G + SP P L C + I V PG + +Q + ++L + G
Sbjct: 1317 ESSGRILSPGYPFPYDNNLR---CMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPE 1373
Query: 239 GLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CGFPPRPA 297
+ S++ EG + S N + + F + GF I + + + + C P P
Sbjct: 1374 NDMLLKEISGSLIPEG--IHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPM 1431
Query: 298 HGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLN-GTRPSWNGETPSCMASCGGTIHNA 356
+G + PG T F CD GY+LQGEE + C+ R W P C+A CGG + +
Sbjct: 1432 NGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGS 1491
Query: 357 TLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPV 416
+ G I+SP + C W I + L F S++ + D L + G SP+
Sbjct: 1492 S-GFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPL 1550
Query: 417 IYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV-- 474
I +PER + S + ++++ S+ + L ++A + CF P GN+
Sbjct: 1551 IGSFQDSKLPER-IESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDP----GNIMN 1605
Query: 475 -TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEPHWNDTEPACKAMCGGEL 531
T +Y+ G+ T+ C GY L+ + + C+ D P WN P+C A CG
Sbjct: 1606 GTRLGMDYKLGSTVTYYCDAGYVLQGY---STLTCIMGDDGRPGWNRALPSCHAPCGSRS 1662
Query: 532 SEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSAR 591
+ G VLSP++P++YS G +CV+ + V +E + Q D++ ++DG +
Sbjct: 1663 TGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSS 1722
Query: 592 VLAQLRGPQPRRRL-LSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDT--CPELP 648
+L+ L G L LSSG +T++F + P +GF ++ VPR + C +P
Sbjct: 1723 LLSSLSGSHSGESLPLSSGNQITIRFTS----VGPITAKGFHFVYQAVPRTSSTQCSSVP 1778
Query: 649 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC--------QWDLSWSAAPPACQ 700
P +G R + + G+ + + C PGY L GS + C QW+ S C
Sbjct: 1779 EPRFGRRIGN--EFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG 1836
Query: 701 KIMTCADPGEIANGHRTASDAGF--------PVGSHVQYRCLPGYSLE------------ 740
I+T ++ G+ D P G+ +Q + + ++ E
Sbjct: 1837 GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVV-SFATEHNWDSLDFYDGG 1895
Query: 741 --GAAMLTCYS--------------------RDTGTPKWSDRVPKCALKYEPCLNPGVPE 778
A L YS D + A+ + C P P
Sbjct: 1896 DNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPS 1955
Query: 779 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSR 838
+G + Y G+ + F C +G+ L G ITC+PG +W P+C + Q
Sbjct: 1956 SGIK--IGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC-LAQCGGAMS 2012
Query: 839 QLEG--------GNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGF----SGSHSYSP 886
G GN ++ + + +G GV++ + +++ + SGS S
Sbjct: 2013 DFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETST 2072
Query: 887 I 887
+
Sbjct: 2073 V 2073
Score = 204 bits (519), Expect = 3e-52
Identities = 180/667 (26%), Positives = 280/667 (41%), Gaps = 41/667 (6%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C +S+ G + SP +L DCT++I++ G+G+ +Q + + L +
Sbjct: 2007 CGGAMSDFSGVILSPGFPGNYPSSL---DCTWTINLPIGFGVHLQFVNFSTETIHDYLEV 2063
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGF 292
G S ++ S L S T+ L+F S GF I YQAY L
Sbjct: 2064 RSGSSE--TSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCP 2121
Query: 293 PPRP-AHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGG 351
PRP +G V D G T +F C GY L G L CL+G +WN P C A CGG
Sbjct: 2122 DPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGG 2181
Query: 352 TIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGS 411
I A G I SP C W++ G ++++F + + D + V G
Sbjct: 2182 NI-TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPD 2240
Query: 412 PLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPF-LA 470
SP I + E + S + + ++ S+ + + L + A++ C P +
Sbjct: 2241 QNSPQIGQFSGNTALE-SVYSTSNQILIKFHSDFTTSGFFV-LSYHAYQLRVCQPPPPVP 2298
Query: 471 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAI-ECVDPTEPHWNDTEPACKAMC-G 528
+ + T D E+ G + + CLPG+ L NAI C + P C+ +C
Sbjct: 2299 NAEILTEDDEFEIGDIIRYQCLPGFTLVG----NAILTCRLGERLQMDGAPPVCQVLCPA 2354
Query: 529 GELS-EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNV-REGDMLTLFDGD 586
EL + GV+LSP +P SY Q C W + V++ I + VE +E D+L ++DG
Sbjct: 2355 NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGP 2414
Query: 587 GPSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCP 645
+ VL L G + S+G ++ LQ+ A G G ++ + P +
Sbjct: 2415 NIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPES---- 2470
Query: 646 ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDL----SWSAAPPACQK 701
PP + + G L +V+ + C+ G+ L+G C+ +W A PACQ
Sbjct: 2471 ---PPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQA 2525
Query: 702 IMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV 761
I +C P NG +D + VG+ V Y C GY L + T + GT ++
Sbjct: 2526 I-SCGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKT 2582
Query: 762 PKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 821
P+C + C P NG + + Y G + F C GF L+G C+ W
Sbjct: 2583 PRCVV--ISCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSS--GLW 2636
Query: 822 TSQPPLC 828
+ C
Sbjct: 2637 SESETRC 2643
Score = 182 bits (463), Expect = 9e-46
Identities = 154/570 (27%), Positives = 238/570 (41%), Gaps = 29/570 (5%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C + + EG + SP+ +C YSI V G GI I +T +L+Q + L +
Sbjct: 1137 CGASATNNEGILLSPNYPLNYENNH---ECIYSIQVQAGKGINISARTFHLAQGDVLKIY 1193
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CG 291
G +SM G L S +N+L L F S GF++ Y ++ LS C
Sbjct: 1194 DGKDKTTHLLGAFTGASM--RGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCE 1251
Query: 292 FPPRPAHG-DVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 350
P P G +S G T + C+ GY L G L C+ G R +W+ PSC+A CG
Sbjct: 1252 DPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECG 1311
Query: 351 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 410
G + GRI+SP NL C W+IE G + L F + +D L V G
Sbjct: 1312 GRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGP 1371
Query: 411 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 470
++ + +PE G+ S + ++ ++ + +++F + C P +
Sbjct: 1372 PENDMLLKEISGSLIPE-GIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVP 1430
Query: 471 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPH-WNDTEPACKAMCGG 529
N T PG F C PGY L+ I C+ + W + P C A CGG
Sbjct: 1431 M-NGTRNGDGREPGDTVVFQCDPGYELQ---GEERITCIQVENRYFWQPSPPVCIAPCGG 1486
Query: 530 ELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-DMLTLFDGDGP 588
L+ +G +LSP++P Y +DC W + V + I L ++ D L ++DG
Sbjct: 1487 NLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDS 1546
Query: 589 SARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELP 648
++ ++ + + R+ SS + L F++ GF L +K R ++C
Sbjct: 1547 NSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSY----TGFHLEYKAKLR-ESC--FD 1599
Query: 649 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPACQKIMT 704
P T D G+ +TY C+ GY L G LTC W+ A P+C
Sbjct: 1600 PGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH--AP 1657
Query: 705 CADPGEIANGHRTASDAGFPVGSHVQYRCL 734
C + G T +P V + C+
Sbjct: 1658 CGSRSTGSEG--TVLSPNYPKNYSVGHNCV 1685
Score = 171 bits (432), Expect = 4e-42
Identities = 193/787 (24%), Positives = 301/787 (38%), Gaps = 119/787 (15%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C N++ G++ SP+ P + DC ++I V Y I + + ++ + L +
Sbjct: 1484 CGGNLTGSSGFILSPNFPHPYPHSR---DCDWTITVNADYVISLAFISFSIEPNYDFLYI 1540
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSP------TNRLLLHFQSPRVPRGGGFRIHYQAY 286
G +NS ++G Q + P +N + L F+S GF + Y+A
Sbjct: 1541 YDGPD--------SNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK 1592
Query: 287 LL-SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETP 343
L SC P +G D G T T++CD+GY LQG TL C+ G RP WN P
Sbjct: 1593 LRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1652
Query: 344 SCMASCGGTIHNATLGRIVSPE--PGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN 401
SC A CG + G ++SP +VG N + F + SL +
Sbjct: 1653 SCHAPCGSR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL---H 1708
Query: 402 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAF-- 459
D + V G + S ++ E +S + + S P ++A
Sbjct: 1709 DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPR 1768
Query: 460 -EEDRCFA-PFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIEC--VDPTEPH 515
+C + P G E+ G+ F C PGY L AI C V +
Sbjct: 1769 TSSTQCSSVPEPRFGR--RIGNEFAVGSSVLFDCNPGYILHGS---IAIRCETVPNSLAQ 1823
Query: 516 WNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQV-EILNV 574
WND+ P C CGG L++ G +LSP +P+ Y +CVW + V E I +QV
Sbjct: 1824 WNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATE 1883
Query: 575 REGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLH 634
D L +DG +A L G L S+ +L L FQ+ GF L
Sbjct: 1884 HNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVS----AAGFHLE 1939
Query: 635 FKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD--LSW 692
+ + D+CPE P G + + G V+++QC+ GY L G +TC W
Sbjct: 1940 YTAIGL-DSCPEPQTPSSGIKIGDR--YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRW 1996
Query: 693 SAAPPACQK------------IMTCADPGEIANGHRTASDAGFPVGS--HVQYRCLPGYS 738
+ P C I++ PG + P+G H+Q+ +
Sbjct: 1997 NYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET 2056
Query: 739 LEGAAMLTCYSRDTGTP-------------------------------KWSDRVPKCALK 767
+ + S +T T K + A +
Sbjct: 2057 IHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQ 2116
Query: 768 YEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 827
+ C +P NG+ + + + G+++ F C+ G+ LIG +TC+ G W P
Sbjct: 2117 LQSCPDPRPFRNGF--VIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPR 2174
Query: 828 CKVTQTTDPSRQLEGGNLAL---AILLP------------LGLV-IVLGSGVYIYYTKLQ 871
C+ L GGN+ I P LV + G+G+YI +T LQ
Sbjct: 2175 CEA---------LCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQ 2225
Query: 872 GKSLFGF 878
+ ++ F
Sbjct: 2226 TEPIYDF 2232
Score = 167 bits (422), Expect = 5e-41
Identities = 138/556 (24%), Positives = 231/556 (41%), Gaps = 23/556 (4%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIH-VYPGYGIEIQVQTLNLSQEEELLV 231
C +N+ G SP+ C + I V I+I + +L + L
Sbjct: 444 CGSNLQGPSGTFTSPNFPFQYDSNA---QCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 500
Query: 232 LAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-SC 290
+ GG G +L + ++ S ++++ LH Q+ GF+++Y+ SC
Sbjct: 501 IGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESC 560
Query: 291 GFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCG 350
G P P +G F C G++L GE++++C + W+ P C+ C
Sbjct: 561 GDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQ--WSANIPICIFPCL 618
Query: 351 GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGG 410
A +G ++SP+ G NL C W I + G R+HL F L+ D L V+ G
Sbjct: 619 SNF-TAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGD 677
Query: 411 SPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLA 470
SP SP++ +VP L S++ L +E ++ + ++ + F + C P +
Sbjct: 678 SPESPILGTFTGAEVPSH-LTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIP 736
Query: 471 HGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGE 530
N ++ G+ + C G+ ++ G + + W+ P C A CGG
Sbjct: 737 I-NARRFGDNFQLGSSISVICEEGF-IKTQGTETITCILMDGKVMWSGLIPKCGAPCGGH 794
Query: 531 LSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDGPS 589
S P+GV+LSP WP Y +C W + + I + E D+L + DG
Sbjct: 795 FSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLL 854
Query: 590 ARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRND-TCPELP 648
+ +L G Q + L SS + L F N GF +H++ V N +C +
Sbjct: 855 SPLLGSYNGTQVPQFLFSSSNFIYLLFTT----DNSRSNNGFKIHYESVTVNTYSCLDPG 910
Query: 649 PPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADP 708
P G R D G+ +++ C+ GY L + L C+ + WS P C + C
Sbjct: 911 IPVHGRRYGH--DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL--CG-- 964
Query: 709 GEIANGHRTASDAGFP 724
G++ T G+P
Sbjct: 965 GDVRGPSGTILSPGYP 980
Score = 131 bits (330), Expect = 2e-30
Identities = 154/572 (26%), Positives = 231/572 (40%), Gaps = 68/572 (11%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C + G +ESP G P G +CT+ I I+I Q+ L +E + L L
Sbjct: 65 CGGTLKGLNGTIESP--GFPYGYPNGA-NCTWVIIAEERNRIQIVFQSFALEEEYDYLSL 121
Query: 233 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLS-CG 291
G R L + S + L S GF+++Y+ S CG
Sbjct: 122 YDGHPHPTNFRTRLTGFHLPPP--VTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 179
Query: 292 FPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGT--RPSWNGETPSCMA-- 347
P P G + T G + C +GY L G L C+ + SW+ P C A
Sbjct: 180 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 239
Query: 348 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVR 407
+CGGT+ ++ G I SP N C W I A G + L F ++E D L +
Sbjct: 240 ACGGTMRGSS-GIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI- 297
Query: 408 SGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFE----EDR 463
G P P I+ S M+ P +IS+ L + ++++ S ++ + + R
Sbjct: 298 EGSEP--PTIWLSGMNIPPP--IISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKSR 353
Query: 464 CFAPF-----------LAHGNVTTT-----DP-----------EYRPGALATFSCLPGYA 496
F F L G + T DP ++ G+ FSC Y
Sbjct: 354 GFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYV 413
Query: 497 LEPPGPPNAIECVDPTE--PHWNDTEPACKA-MCGGELSEPAGVVLSPDWPQSYSPGQDC 553
L+ +I C E W+D P CK CG L P+G SP++P Y C
Sbjct: 414 LQ---GAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQC 470
Query: 554 VWGV-HVQEEKRILLQVEILNVREG-DMLTLFDGD--GPSARVLAQLRGPQPRRRLLSSG 609
VW + V K I + E ++ G D LT+ DG G VL L G ++S
Sbjct: 471 VWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMS 530
Query: 610 PDLTLQFQAPPGPPNPGLGQ-GFVLHFKEVPRNDTCPELPPPEWGWRTASHGD-LIRGTV 667
+ L Q + +G GF +++KE+ + ++C + P +G R GD V
Sbjct: 531 SQMWLHLQT-----DESVGSVGFKVNYKEIEK-ESCGDPGTPLYGIR---EGDGFSNRDV 581
Query: 668 LTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 699
L ++C+ G+EL+G + CQ + WSA P C
Sbjct: 582 LRFECQFGFELIGEKSIVCQENNQWSANIPIC 613
Score = 128 bits (321), Expect = 3e-29
Identities = 132/581 (22%), Positives = 224/581 (38%), Gaps = 88/581 (15%)
Query: 173 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL 232
C + G + SP + DCT++I PG I + + ++ + L +
Sbjct: 241 CGGTMRGSSGIISSPSFPNEYHNNA---DCTWTIVAEPGDTISLIFTDFQMEEKYDYLEI 297
Query: 233 AGGGSP-------GLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQA 285
G P + P +++N N L LHF + R GF YQ
Sbjct: 298 EGSEPPTIWLSGMNIPPPIISNK-------------NWLRLHFVTDSNHRYRGFSAPYQV 344
Query: 286 Y-----------------------LLS----------CGFPPRPAHGDVSVTDLHPGGTA 312
+L+ C P P +G +D G T
Sbjct: 345 KKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTV 404
Query: 313 TFHCDSGYQLQGEETLIC--LNGTRPSWNGETPSC-MASCGGTIHNATLGRIVSPEPGGA 369
F CD Y LQG +++ C + +W+ P C + +CG + + G SP
Sbjct: 405 QFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPS-GTFTSPNFPFQ 463
Query: 370 VGPNLTCRWVIEAAEGRR-LHLHFERVSLDEDNDRLMVRSGGSPLSP-----VIYDSDMD 423
N C WVI A + + ++FE L+ D L + GG P V+ S +
Sbjct: 464 YDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVP 523
Query: 424 DVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRP 483
D+ ++S + +++ L ++ + + ++ E++ C P + D +
Sbjct: 524 DL----IVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGD-GFSN 578
Query: 484 GALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDW 543
+ F C G+ L +I C + + W+ P C C + P G VLSPD+
Sbjct: 579 RDVLRFECQFGFELI---GEKSIVCQENNQ--WSANIPICIFPCLSNFTAPMGTVLSPDY 633
Query: 544 PQSYSPGQDCVWGVHVQEEKRILLQVEILNVR-EGDMLTLFDGDGPSARVLAQLRGPQPR 602
P+ Y +C+W + RI L ++ + D L + DGD P + +L G +
Sbjct: 634 PEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVP 693
Query: 603 RRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDL 662
L S+ L L+FQA + G+GF + + N+ CP+ P R + L
Sbjct: 694 SHLTSNSHILRLEFQA----DHSMSGRGFNITYNTFGHNE-CPDPGIPINARRFGDNFQL 748
Query: 663 IRGTVLTYQCEPGY-ELLGSDILTC---QWDLSWSAAPPAC 699
G+ ++ CE G+ + G++ +TC + WS P C
Sbjct: 749 --GSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 787
Score = 92.0 bits (227), Expect = 2e-18
Identities = 106/445 (23%), Positives = 163/445 (36%), Gaps = 75/445 (16%)
Query: 342 TPSCMA----SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSL 397
T SC+ +CGGT+ G I SP C WVI A E R+ + F+ +L
Sbjct: 54 TVSCVKGFIYTCGGTLKGLN-GTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFAL 112
Query: 398 DEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-VELLSETPANPLLLSLRF 456
+E+ D L + G P + + + ++ +S++ + L S+ + + +
Sbjct: 113 EEEYDYLSLYDGHP--HPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 170
Query: 457 EAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECV--DPTEP 514
E + C P + V + G +SC+ GY L+ G P + C+
Sbjct: 171 EELQSSSCGNPGVPPKGVLY-GTRFDVGDKIRYSCVTGYILD--GHPQ-LTCIANSVNTA 226
Query: 515 HWNDTEPACKA--MCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEIL 572
W+ P C+A CGG + +G++ SP +P Y DC W + + I L
Sbjct: 227 SWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDF 286
Query: 573 NVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFV 632
+ E +G P L+ + P P ++S+ L L F G +
Sbjct: 287 QMEEKYDYLEIEGSEPPTIWLSGMNIPPP---IISNKNWLRLHFVTDSNHRYRGFSAPYQ 343
Query: 633 LH---------FKEVPRNDTCPELPP-PEWGWRTASHGDLIRGTVLTYQCEPGYELLGSD 682
+ FK P D + E G +TAS+
Sbjct: 344 VKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASN----------------------- 380
Query: 683 ILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGA 742
C DPGE NG R SD F +GS VQ+ C Y L+GA
Sbjct: 381 ---------------------LCPDPGEPENGKRIGSD--FSLGSTVQFSCDEDYVLQGA 417
Query: 743 AMLTCYSRDTGTPKWSDRVPKCALK 767
+TC WSD P C +K
Sbjct: 418 KSITCQRIAEVFAAWSDHRPVCKVK 442
Score = 89.0 bits (219), Expect = 2e-17
Identities = 62/203 (30%), Positives = 85/203 (41%), Gaps = 12/203 (5%)
Query: 641 NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 700
N + P +P HG+ GTV+ Y C PGY L GS +L CQ + W P C
Sbjct: 2763 NCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2822
Query: 701 KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 760
I C PG N S + GS V Y C SL G + TC WS
Sbjct: 2823 MI-DCGHPGVPPNA--VLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG----HWSGS 2875
Query: 761 VPKCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPS 819
P C+ C +PG P G+ + + +++ ++R+ C G+ L G TC+
Sbjct: 2876 QPHCSGDATGTCGDPGTP--GHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLAN--G 2931
Query: 820 QWTSQPPLCKVTQTTDPSRQLEG 842
WT + P CK Q +P G
Sbjct: 2932 SWTGRQPECKAVQCGNPGTTANG 2954
Score = 85.9 bits (211), Expect = 2e-16
Identities = 63/195 (32%), Positives = 89/195 (45%), Gaps = 21/195 (10%)
Query: 656 TASHGDLIR--GTVLT----YQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPG 709
T ++G + R GT + Y C GY L G + C + +WS P C I++C DPG
Sbjct: 2950 TTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNC-TIISCGDPG 3008
Query: 710 EIANGHRTASDAGFPVGSHVQYRCLPGYSLE--GAAMLTCYSRDTGTPKWSDRVPKCALK 767
ANG R D + VG +V Y C PGY++E G+ + TC T WS +P C +
Sbjct: 3009 IPANGLRYGDD--YVVGQNVSYMCQPGYTMELNGSRIRTCTINGT----WSGVMPTC--R 3060
Query: 768 YEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 827
C P NG L ++ G S+ + C G+EL +TCV W+ + P
Sbjct: 3061 AVTCPTPPQISNG--RLEGTNFDWGFSISYICSPGYELSFPAVLTCVGN--GTWSGEVPQ 3116
Query: 828 CKVTQTTDPSRQLEG 842
C DP +G
Sbjct: 3117 CLPKFCGDPGIPAQG 3131
Score = 83.2 bits (204), Expect = 1e-15
Identities = 62/187 (33%), Positives = 82/187 (43%), Gaps = 13/187 (6%)
Query: 643 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 702
TCP P G ++ D G ++Y C PGYEL +LTC + +WS P C
Sbjct: 3063 TCPTPPQISNGRLEGTNFDW--GFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP- 3119
Query: 703 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 762
C DPG A G R F S V + C + L G++ C + T WS P
Sbjct: 3120 KFCGDPGIPAQGKREGK--SFIYQSEVSFSCNFPFILVGSSTRICQADGT----WSGSSP 3173
Query: 763 KCALKYE-PCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 821
C + C NPGVP +G Q +Q G ++F C +G L G T TC+P W
Sbjct: 3174 HCIEPTQTSCENPGVPRHGSQN-NTFGFQVGSVVQFHCKKGHLLQGSTTRTCLP--DLTW 3230
Query: 822 TSQPPLC 828
+ P C
Sbjct: 3231 SGIQPEC 3237
Score = 82.4 bits (202), Expect = 2e-15
Identities = 53/167 (31%), Positives = 74/167 (44%), Gaps = 14/167 (8%)
Query: 664 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF 723
R TV+ YQC PG+ L+GS + CQ D +WS P+C + +C PG G S GF
Sbjct: 2667 RDTVV-YQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV-SCGHPGSPIYGR--TSGNGF 2722
Query: 724 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT 783
V + C GY ++G C + +WS P C K C +PG+P N +
Sbjct: 2723 NFNDVVTFSCNIGYLMQGPTKAQCQA----NRQWSHPPPMC--KVVNCSDPGIPANSKRE 2776
Query: 784 LYKHH--YQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 828
H + G + + C G+ L G + C P QW P C
Sbjct: 2777 SKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN--GQWDKPLPEC 2821
Score = 73.6 bits (179), Expect = 8e-13
Identities = 63/245 (25%), Positives = 97/245 (39%), Gaps = 37/245 (15%)
Query: 643 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 702
+C ELP P G + + G+ + C+ G+ L+GS + C WS + C
Sbjct: 2589 SCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLA- 2645
Query: 703 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 762
C P I NG + G+ V Y+C PG+ L G+++ C WS ++P
Sbjct: 2646 GHCGIPELIVNGQVIGENYGYR--DTVVYQCNPGFRLIGSSVRICQQDHN----WSGQLP 2699
Query: 763 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 822
C C +PG P G + + + + + F C G+ + G C QW+
Sbjct: 2700 SCVPV--SCGHPGSPIYGRTS--GNGFNFNDVVTFSCNIGYLMQGPTKAQCQANR--QWS 2753
Query: 823 SQPPLCKVTQTTDP--------SRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKS 874
PP+CKV +DP ++E GN G ++Y G
Sbjct: 2754 HPPPMCKVVNCSDPGIPANSKRESKIEHGNFTY--------------GTVVFYDCNPGYF 2799
Query: 875 LFGFS 879
LFG S
Sbjct: 2800 LFGSS 2804
Score = 53.5 bits (127), Expect = 9e-07
Identities = 44/136 (32%), Positives = 57/136 (41%), Gaps = 13/136 (9%)
Query: 236 GSPGLAPRLLANSSMLGEGQVLR-SPTNRLLLHFQSPRVPRGGGFRIHYQAYLL-----S 289
G PG+ P + + G + S T + L QS R + G Q + +
Sbjct: 2827 GHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGT 2886
Query: 290 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCMA- 347
CG P P HG ++ T + CD+GY L G E CL NG SW G P C A
Sbjct: 2887 CGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANG---SWTGRQPECKAV 2943
Query: 348 SCG--GTIHNATLGRI 361
CG GT N + RI
Sbjct: 2944 QCGNPGTTANGKVFRI 2959
Score = 52.0 bits (123), Expect = 3e-06
Identities = 40/130 (30%), Positives = 59/130 (45%), Gaps = 14/130 (10%)
Query: 639 PRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPA 698
P +C P G + + G + G+V+ + C+ G+ L GS TC DL+WS P
Sbjct: 3178 PTQTSCENPGVPRHGSQNNTFGFQV-GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPE 3236
Query: 699 CQKIMTCADPGEIANGHRTASDAGFPVGSH---VQYRCLPGYSLEGAA-MLTCYSRDTGT 754
C +C P A+ A+ G + SH + Y C PG+ L G C S +T
Sbjct: 3237 CIP-HSCKQPETPAH----ANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNT-- 3289
Query: 755 PKWSDRVPKC 764
W+ +VP C
Sbjct: 3290 --WTGKVPIC 3297
Score = 44.3 bits (103), Expect = 5e-04
Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 4/66 (6%)
Query: 766 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPG--HPSQWTS 823
L+ C NPGVP G LY + G+ +R+ C G+ L G +TC+ + + W
Sbjct: 173 LQSSSCGNPGVPPKG--VLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 230
Query: 824 QPPLCK 829
P+C+
Sbjct: 231 PVPICR 236
Score = 42.0 bits (97), Expect = 0.003
Identities = 22/65 (33%), Positives = 36/65 (55%), Gaps = 5/65 (7%)
Query: 288 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCM 346
++C PP+ ++G + T+ G + ++ C GY+L L C+ NGT W+GE P C+
Sbjct: 3062 VTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGT---WSGEVPQCL 3118
Query: 347 AS-CG 350
CG
Sbjct: 3119 PKFCG 3123
Score = 41.2 bits (95), Expect = 0.004
Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 4/63 (6%)
Query: 766 LKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQP 825
++ E C +PG P G + + + LRF C GFELIGE +I C +QW++
Sbjct: 555 IEKESCGDPGTPLYGIRE--GDGFSNRDVLRFECQFGFELIGEKSIVCQEN--NQWSANI 610
Query: 826 PLC 828
P+C
Sbjct: 611 PIC 613
Score = 40.8 bits (94), Expect = 0.006
Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 2/81 (2%)
Query: 287 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 346
++SCG P P +G+ T G TA F CD G+ L G CL+ W+ C+
Sbjct: 2587 VISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSS--GLWSESETRCL 2644
Query: 347 ASCGGTIHNATLGRIVSPEPG 367
A G G+++ G
Sbjct: 2645 AGHCGIPELIVNGQVIGENYG 2665
Score = 40.4 bits (93), Expect = 0.008
Identities = 39/148 (26%), Positives = 55/148 (37%), Gaps = 27/148 (18%)
Query: 769 EPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQ--WTSQPP 826
E C +PG NG T Y+ G ++ ++C G+ L G T+TC+ G + W P
Sbjct: 1595 ESCFDPGNIMNG--TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALP 1652
Query: 827 LC-------------KVTQTTDPSRQLEGGNLALAILLPLGLVIV---------LGSGVY 864
C V P G N +I +P V+ L V
Sbjct: 1653 SCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVE 1712
Query: 865 IYYTKLQGKSLF-GFSGSHSYSPITVES 891
+Y Q SL SGSHS + + S
Sbjct: 1713 VYDGPTQQSSLLSSLSGSHSGESLPLSS 1740
Score = 40.4 bits (93), Expect = 0.008
Identities = 22/59 (37%), Positives = 27/59 (45%), Gaps = 3/59 (5%)
Query: 289 SCGFPPRPAHGDVSVT-DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 346
SC P P HG + T G FHC G+ LQG T CL +W+G P C+
Sbjct: 3182 SCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDL--TWSGIQPECI 3238
Score = 38.5 bits (88), Expect = 0.029
Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 4/62 (6%)
Query: 771 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC--VPGHPSQWTSQPPLC 828
C +PG PENG + + G +++F C E + L G +ITC + + W+ P+C
Sbjct: 382 CPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 439
Query: 829 KV 830
KV
Sbjct: 440 KV 441
Score = 38.5 bits (88), Expect = 0.029
Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 3/62 (4%)
Query: 290 CGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-AS 348
CG P +G V + T + C+ G++L G IC +W+G+ PSC+ S
Sbjct: 2648 CGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQD--HNWSGQLPSCVPVS 2705
Query: 349 CG 350
CG
Sbjct: 2706 CG 2707
Score = 38.5 bits (88), Expect = 0.029
Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 6/78 (7%)
Query: 287 LLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGY--QLQGEETLIC-LNGTRPSWNGETP 343
++SCG P PA+G D G ++ C GY +L G C +NGT W+G P
Sbjct: 3001 IISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGT---WSGVMP 3057
Query: 344 SCMASCGGTIHNATLGRI 361
+C A T + GR+
Sbjct: 3058 TCRAVTCPTPPQISNGRL 3075
Score = 35.8 bits (81), Expect = 0.19
Identities = 18/58 (31%), Positives = 24/58 (41%), Gaps = 2/58 (3%)
Query: 288 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 345
+SCG P P +G S + TF C+ GY +QG C W+ P C
Sbjct: 2704 VSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQC--QANRQWSHPPPMC 2759
Score = 35.0 bits (79), Expect = 0.32
Identities = 20/70 (28%), Positives = 29/70 (41%), Gaps = 4/70 (5%)
Query: 284 QAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGET 342
+ ++ CG P P + +S G T + C L G+ + C LNG W+G
Sbjct: 2820 ECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNG---HWSGSQ 2876
Query: 343 PSCMASCGGT 352
P C GT
Sbjct: 2877 PHCSGDATGT 2886
Score = 34.3 bits (77), Expect = 0.54
Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 4/61 (6%)
Query: 289 SCGFPPRPAHGDVSVTDLHPGG-TATFHCDSGYQLQ-GEETLICLNGTRPSWNGETPSCM 346
SC P PAH +V DL G T + C G+ L G E +C + +W G+ P C
Sbjct: 3241 SCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDN--TWTGKVPICE 3298
Query: 347 A 347
A
Sbjct: 3299 A 3299
Score = 32.7 bits (73), Expect = 1.6
Identities = 20/73 (27%), Positives = 39/73 (53%), Gaps = 5/73 (6%)
Query: 830 VTQTTDPSRQLEGGN---LALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSP 886
+++ ++ S Q G N +A+AIL+P +I G G Y+Y + K+ ++G +
Sbjct: 3444 MSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKT--QYTGCSVHEN 3501
Query: 887 ITVESDFSNPLYE 899
++ F NP+Y+
Sbjct: 3502 NNGQAAFENPMYD 3514
Score = 31.6 bits (70), Expect = 3.5
Identities = 15/52 (28%), Positives = 27/52 (51%), Gaps = 7/52 (13%)
Query: 656 TASHGDLI------RGTVLTYQCEPGYELLG-SDILTCQWDLSWSAAPPACQ 700
T +H +++ G L Y C+PG+ L G ++ C+ D +W+ P C+
Sbjct: 3247 TPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICE 3298
Score = 31.2 bits (69), Expect = 4.6
Identities = 28/80 (35%), Positives = 35/80 (43%), Gaps = 11/80 (13%)
Query: 287 LLSCGFPPRPAHGDVSVTDLHPG---GTATFH-CDSGYQLQGEETLICL-NGTRPSWNGE 341
+++C P PA+ H GT F+ C+ GY L G LIC NG W+
Sbjct: 2761 VVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNG---QWDKP 2817
Query: 342 TPSC-MASCG--GTIHNATL 358
P C M CG G NA L
Sbjct: 2818 LPECIMIDCGHPGVPPNAVL 2837
>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
Length = 2489
Score = 104 bits (260), Expect = 3e-22
Identities = 149/630 (23%), Positives = 229/630 (36%), Gaps = 120/630 (19%)
Query: 290 CGFPPRPAHGDVSVT---DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC- 345
C PP HG+ + + + PG + C+ GY L+G +L C + W+ E P C
Sbjct: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCT--PQGDWSPEAPRCA 1704
Query: 346 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRL------HLHF------- 392
+ SC + GR++ P + L + EG RL H
Sbjct: 1705 VKSCDDFLGQLPHGRVLFP-----LNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLW 1759
Query: 393 -------ERVSLDEDNDRLMVRSGGSPLSPVIYDSDM----DDVPERGL---------IS 432
E + L R G+P + Y ++ D P+RG+ I
Sbjct: 1760 NNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIR 1819
Query: 433 DAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCL 492
+ + +PA LS+R + F PF A + D E+ G + C
Sbjct: 1820 CTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQF-PF-ASPTIPINDFEFPVGTSLNYECR 1877
Query: 493 PGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSY----- 547
PGY G +I C++ W+ E C+ G EP ++ + +
Sbjct: 1878 PGYF----GKMFSISCLENLV--WSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVN 1931
Query: 548 -----------SPGQDC-VWGVHVQEEKRILLQVEILNVR-------------------E 576
SP C V G +V +K+ + EI++
Sbjct: 1932 YSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPI-CEIISCEPPPTISNGDFYSNNRTSFHN 1990
Query: 577 GDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFK 636
G ++T GP L +L G R + + D + + P P +
Sbjct: 1991 GTVVTYQCHTGPDGEQLFELVG---ERSIYCTSKDDQVGVWSSPPP-------------R 2034
Query: 637 EVPRND-TCPELPPPEWGWRTASHGDLIRGT-VLTYQCEPGYELLGSDILTCQWDLSWSA 694
+ N T PE+ E R + T ++ ++C+PG+ ++GS + CQ + W
Sbjct: 2035 CISTNKCTAPEV---ENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGP 2091
Query: 695 APPACQKIMTCADPGEIANGHRTAS-DAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTG 753
P C ++ C P EI +G T S F G V Y C P Y L GAA L C T
Sbjct: 2092 KLPHCSRV--CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHC----TP 2145
Query: 754 TPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC 813
WS P+C +K +P + L + Q G + F C EGF L G C
Sbjct: 2146 QGDWSPEAPRCTVKSCDDFLGQLPHG--RVLLPLNLQLGAKVSFVCDEGFRLKGRSASHC 2203
Query: 814 V-PGHPSQWTSQPPLCKVTQTTDPSRQLEG 842
V G + W S P+C+ +P L G
Sbjct: 2204 VLAGMKALWNSSVPVCEQIFCPNPPAILNG 2233
Score = 87.4 bits (215), Expect = 5e-17
Identities = 143/603 (23%), Positives = 229/603 (37%), Gaps = 113/603 (18%)
Query: 305 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC---MASCGGTIHNAT-LG 359
+L G F CD G+QL+G C L G WN P C I N G
Sbjct: 1275 NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTG 1334
Query: 360 RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYD 419
+ + P G N TC H +R + + +R P ++
Sbjct: 1335 KPLEVFPFGKA-VNYTC------------DPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 1381
Query: 420 SDMDDVPERGLISDAQS----LYVELLSETPAN--PLLLSLRFEAFEE--DRCFAPFLAH 471
S P G++ Q+ L+ +L ++T A+ P+ SL++E E R F+
Sbjct: 1382 SP---APRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 1438
Query: 472 GNV--------------TTTDP---------EYRPGALATFSCLPGYALEPPGPPNAIEC 508
V T DP + + G+ +SC G+ L ++ EC
Sbjct: 1439 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH---SSAEC 1495
Query: 509 V-DPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRIL 566
+ HW+ P C+ + CG + G +S + +++ G + ++ R +
Sbjct: 1496 ILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN-RENFHYGSVVTYRCNLGSRGRKV 1554
Query: 567 LQV----EILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP------DLTLQF 616
++ I D + ++ G P + + P +L S + ++F
Sbjct: 1555 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 1614
Query: 617 QAPPGPPNPGLGQGFVLHFKEVPRNDTC-------PELP--------PPE--WGWRTASH 659
+ PG FV+ + PR C PELP PPE G T SH
Sbjct: 1615 RCQPG---------FVM---KGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSH 1662
Query: 660 GDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRT 717
D G + Y CEPGY+L G+ L C WS P C + +C D G++ +G R
Sbjct: 1663 QDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC-AVKSCDDFLGQLPHG-RV 1720
Query: 718 ASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVP 777
+G+ V + C G+ L+G+++ C + W++ VP C ++ C NP
Sbjct: 1721 LFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRS-LWNNSVPVC--EHIFCPNPPAI 1777
Query: 778 ENGYQT-LYKHHYQAGESLRFFCYE------GFELIGEVTITCV--PGHPSQWTSQPPLC 828
NG T G+ + + C F LIGE TI C P W+S P C
Sbjct: 1778 LNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRC 1837
Query: 829 KVT 831
+++
Sbjct: 1838 ELS 1840
Score = 87.0 bits (214), Expect = 7e-17
Identities = 142/602 (23%), Positives = 228/602 (37%), Gaps = 113/602 (18%)
Query: 305 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC---MASCGGTIHNAT-LG 359
+L G F CD G+QL+G C L G WN P C I N G
Sbjct: 375 NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTG 434
Query: 360 RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYD 419
+ + P G N TC H +R + + +R P ++
Sbjct: 435 KPLEVFPFGKT-VNYTC------------DPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 481
Query: 420 SDMDDVPERGLISDAQS----LYVELLSETPAN--PLLLSLRFEAFEE--DRCFAPFLAH 471
S P G++ Q+ L+ +L ++T A+ P+ SL++E E R F+
Sbjct: 482 SP---APRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 538
Query: 472 GNV--------------TTTDP---------EYRPGALATFSCLPGYALEPPGPPNAIEC 508
V T DP + + G+ +SC G+ L ++ EC
Sbjct: 539 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH---SSAEC 595
Query: 509 V-DPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQ----DCVWGVHVQEE 562
+ HW+ P C+ + CG + G +S + +++ G C G ++
Sbjct: 596 ILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTN-RENFHYGSVVTYRCNPGSGGRKV 654
Query: 563 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP------DLTLQF 616
++ + I D + ++ G P + + P +L S + ++F
Sbjct: 655 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 714
Query: 617 QAPPGPPNPGLGQGFVLHFKEVPRNDTC-------PELP--------PPE--WGWRTASH 659
+ PG FV+ + PR C PELP PP+ RT
Sbjct: 715 RCQPG---------FVM---KGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRD 762
Query: 660 GDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRT 717
D G + Y CEPGY+L G+ + C WS A P C+ + +C D G++ NG R
Sbjct: 763 KDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE-VKSCDDFMGQLLNG-RV 820
Query: 718 ASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVP 777
+G+ V + C G+ L+G++ C + W+ VP C + C +P V
Sbjct: 821 LFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES-LWNSSVPVCEQIF--CPSPPVI 877
Query: 778 ENGYQT-LYKHHYQAGESLRFFC------YEGFELIGEVTITCV--PGHPSQWTSQPPLC 828
NG T + G+++ + C F+LIGE TI C P W+S P C
Sbjct: 878 PNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 937
Query: 829 KV 830
+
Sbjct: 938 GI 939
Score = 87.0 bits (214), Expect = 7e-17
Identities = 142/602 (23%), Positives = 228/602 (37%), Gaps = 113/602 (18%)
Query: 305 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC---MASCGGTIHNAT-LG 359
+L G F CD G+QL+G C L G WN P C I N G
Sbjct: 825 NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTG 884
Query: 360 RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYD 419
+ + P G N TC H +R + + +R P ++
Sbjct: 885 KPLEVFPFGKT-VNYTC------------DPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 931
Query: 420 SDMDDVPERGLISDAQS----LYVELLSETPAN--PLLLSLRFEAFEE--DRCFAPFLAH 471
S P G++ Q+ L+ +L ++T A+ P+ SL++E E R F+
Sbjct: 932 SP---APRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 988
Query: 472 GNV--------------TTTDP---------EYRPGALATFSCLPGYALEPPGPPNAIEC 508
V T DP + + G+ +SC G+ L ++ EC
Sbjct: 989 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH---SSAEC 1045
Query: 509 V-DPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQ----DCVWGVHVQEE 562
+ HW+ P C+ + CG + G +S + +++ G C G ++
Sbjct: 1046 ILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTN-RENFHYGSVVTYRCNPGSGGRKV 1104
Query: 563 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP------DLTLQF 616
++ + I D + ++ G P + + P +L S + ++F
Sbjct: 1105 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 1164
Query: 617 QAPPGPPNPGLGQGFVLHFKEVPRNDTC-------PELP--------PPE--WGWRTASH 659
+ PG FV+ + PR C PELP PP+ RT
Sbjct: 1165 RCQPG---------FVM---KGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRD 1212
Query: 660 GDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRT 717
D G + Y CEPGY+L G+ + C WS A P C+ + +C D G++ NG R
Sbjct: 1213 KDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE-VKSCDDFMGQLLNG-RV 1270
Query: 718 ASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVP 777
+G+ V + C G+ L+G++ C + W+ VP C + C +P V
Sbjct: 1271 LFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES-LWNSSVPVCEQIF--CPSPPVI 1327
Query: 778 ENGYQT-LYKHHYQAGESLRFFC------YEGFELIGEVTITCV--PGHPSQWTSQPPLC 828
NG T + G+++ + C F+LIGE TI C P W+S P C
Sbjct: 1328 PNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 1387
Query: 829 KV 830
+
Sbjct: 1388 GI 1389
Score = 85.5 bits (210), Expect = 2e-16
Identities = 67/254 (26%), Positives = 109/254 (42%), Gaps = 41/254 (16%)
Query: 648 PPPEWGWRTASHGDLI--------RGTVLTYQCEPG------YELLGSDILTCQWDLS-- 691
PPP T S+GD GTV+TYQC G +EL+G + C
Sbjct: 1971 PPP-----TISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQV 2025
Query: 692 --WSAAPPACQKIMTCADPGEIANGHRTASDAGF-PVGSHVQYRCLPGYSLEGAAMLTCY 748
WS+ PP C C P E+ N R + F + +++RC PG+ + G+ + C
Sbjct: 2026 GVWSSPPPRCISTNKCTAP-EVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQ 2084
Query: 749 SRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGE 808
+ +W ++P C+ +P P + + ++ ++ G+ + + C ++L G
Sbjct: 2085 TNG----RWGPKLPHCSRVCQP--PPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGA 2138
Query: 809 VTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYT 868
++ C P W+ + P C V D QL G +LLPL L + G + +
Sbjct: 2139 ASLHCTP--QGDWSPEAPRCTVKSCDDFLGQLPHGR----VLLPLNLQL----GAKVSFV 2188
Query: 869 KLQGKSLFGFSGSH 882
+G L G S SH
Sbjct: 2189 CDEGFRLKGRSASH 2202
Score = 81.3 bits (199), Expect = 4e-15
Identities = 136/577 (23%), Positives = 213/577 (36%), Gaps = 103/577 (17%)
Query: 289 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 346
SC PP P +G V V TD+ G + C +G++L G + C L+G W+ + P C
Sbjct: 553 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
Query: 347 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS-----LDEDN 401
G G +S ++ + GR++ FE V ++
Sbjct: 613 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV---FELVGEPSIYCTSND 669
Query: 402 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-----VE------LLSETPANPL 450
D++ + SG +P + +V L+SD +SL+ VE + + P
Sbjct: 670 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 729
Query: 451 LLSLRFEAFEEDRCF-----APFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPN 504
+L E C P + H T D + + PG +SC PGY L
Sbjct: 730 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA--- 786
Query: 505 AIECVDPTEPHWNDTEPACKA-MCGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEE 562
++ C + W+ P C+ C + + G VL P V++Q
Sbjct: 787 SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP---------------VNLQLG 829
Query: 563 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGP 622
++ + EG L G S VLA + L +S + Q P P
Sbjct: 830 AKVDFVCD-----EGFQL---KGSSASYCVLAGMES------LWNSSVPVCEQIFCPSPP 875
Query: 623 PNP-GLGQGFVLHFKEVPR--NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL 679
P G G L + N TC P P+ RGT ++L+
Sbjct: 876 VIPNGRHTGKPLEVFPFGKTVNYTCD--PHPD------------RGT--------SFDLI 913
Query: 680 GSDILTCQWDLS----WSAAPPACQKIMTCADPGE--IANGHRTASDAGFPVGSHVQYRC 733
G + C D WS+ P C + C P A + + FP+G+ ++Y C
Sbjct: 914 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 973
Query: 734 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGE 793
P Y +TC WS PK K + C P P NG + Q G
Sbjct: 974 RPEY-YGRPFSITCLDNLV----WSS--PKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGS 1025
Query: 794 SLRFFCYEGFELIGEVTITCV-PGHPSQWTSQPPLCK 829
+ + C G LIG + C+ G+ + W+++PP+C+
Sbjct: 1026 RINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 1062
Score = 81.3 bits (199), Expect = 4e-15
Identities = 136/577 (23%), Positives = 213/577 (36%), Gaps = 103/577 (17%)
Query: 289 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 346
SC PP P +G V V TD+ G + C +G++L G + C L+G W+ + P C
Sbjct: 1003 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 1062
Query: 347 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS-----LDEDN 401
G G +S ++ + GR++ FE V ++
Sbjct: 1063 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV---FELVGEPSIYCTSND 1119
Query: 402 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-----VE------LLSETPANPL 450
D++ + SG +P + +V L+SD +SL+ VE + + P
Sbjct: 1120 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 1179
Query: 451 LLSLRFEAFEEDRCF-----APFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPN 504
+L E C P + H T D + + PG +SC PGY L
Sbjct: 1180 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA--- 1236
Query: 505 AIECVDPTEPHWNDTEPACKA-MCGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEE 562
++ C + W+ P C+ C + + G VL P V++Q
Sbjct: 1237 SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP---------------VNLQLG 1279
Query: 563 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGP 622
++ + EG L G S VLA + L +S + Q P P
Sbjct: 1280 AKVDFVCD-----EGFQL---KGSSASYCVLAGMES------LWNSSVPVCEQIFCPSPP 1325
Query: 623 PNP-GLGQGFVLHFKEVPR--NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL 679
P G G L + N TC P P+ RGT ++L+
Sbjct: 1326 VIPNGRHTGKPLEVFPFGKAVNYTCD--PHPD------------RGT--------SFDLI 1363
Query: 680 GSDILTCQWDLS----WSAAPPACQKIMTCADPGE--IANGHRTASDAGFPVGSHVQYRC 733
G + C D WS+ P C + C P A + + FP+G+ ++Y C
Sbjct: 1364 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 1423
Query: 734 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGE 793
P Y +TC WS PK K + C P P NG + Q G
Sbjct: 1424 RPEY-YGRPFSITCLDNLV----WSS--PKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGS 1475
Query: 794 SLRFFCYEGFELIGEVTITCV-PGHPSQWTSQPPLCK 829
+ + C G LIG + C+ G+ + W+++PP+C+
Sbjct: 1476 RINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1512
Score = 80.9 bits (198), Expect = 5e-15
Identities = 64/242 (26%), Positives = 102/242 (42%), Gaps = 33/242 (13%)
Query: 632 VLHFKEVPRNDTCPELPPPEWGWRTASHGDLIR--------GTVLTYQCEPG------YE 677
V+ E P D P PP T ++GD I G+V+TY+C PG +E
Sbjct: 152 VIWDNETPICDRIPCGLPP-----TITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFE 206
Query: 678 LLGSDILTCQWDLS----WSAAPPACQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYR 732
L+G + C + WS P C C P + NG + + F + V++R
Sbjct: 207 LVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPN-VENGILVSDNRSLFSLNEVVEFR 265
Query: 733 CLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAG 792
C PG+ ++G + C + + KW +P C+ +P P V K ++ G
Sbjct: 266 CQPGFVMKGPRRVKCQALN----KWEPELPSCSRVCQP--PPDVLHAERTQRDKDNFSPG 319
Query: 793 ESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLP 852
+ + + C G++L G ++ C P W+ P C+V D QL G + + L
Sbjct: 320 QEVFYSCEPGYDLRGAASMRCTP--QGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQ 377
Query: 853 LG 854
LG
Sbjct: 378 LG 379
Score = 80.5 bits (197), Expect = 7e-15
Identities = 137/577 (23%), Positives = 212/577 (36%), Gaps = 103/577 (17%)
Query: 289 SCGFPPRPAHGDVSVTD-LHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 346
SC PP P +G V V + G + C GY+L G + C ++G W+ ETP C
Sbjct: 103 SCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICD 162
Query: 347 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS-----LDEDN 401
G T G +S ++ + GR++ FE V ++
Sbjct: 163 RIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKV---FELVGEPSIYCTSND 219
Query: 402 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-----VE------LLSETPANPL 450
D++ + SG +P + +V L+SD +SL+ VE + + P
Sbjct: 220 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 279
Query: 451 LLSLRFEAFEEDRCF-----APFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPN 504
+L E C P + H T D + + PG +SC PGY L
Sbjct: 280 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA--- 336
Query: 505 AIECVDPTEPHWNDTEPACKA-MCGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEE 562
++ C + W+ P C+ C + + G VL P V++Q
Sbjct: 337 SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP---------------VNLQLG 379
Query: 563 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGP 622
++ + EG L G S VLA + L +S + Q P P
Sbjct: 380 AKVDFVCD-----EGFQL---KGSSASYCVLAGMES------LWNSSVPVCEQIFCPSPP 425
Query: 623 PNP-GLGQGFVLHFKEVPR--NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL 679
P G G L + N TC P P+ RGT ++L+
Sbjct: 426 VIPNGRHTGKPLEVFPFGKTVNYTCD--PHPD------------RGT--------SFDLI 463
Query: 680 GSDILTCQWDLS----WSAAPPACQKIMTCADPGE--IANGHRTASDAGFPVGSHVQYRC 733
G + C D WS+ P C + C P A + + FP+G+ ++Y C
Sbjct: 464 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 523
Query: 734 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGE 793
P Y +TC WS PK K + C P P NG + Q G
Sbjct: 524 RPEY-YGRPFSITCLDNLV----WSS--PKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGS 575
Query: 794 SLRFFCYEGFELIGEVTITCV-PGHPSQWTSQPPLCK 829
+ + C G LIG + C+ G+ + W+++PP+C+
Sbjct: 576 RINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
Score = 79.3 bits (194), Expect = 1e-14
Identities = 60/227 (26%), Positives = 97/227 (42%), Gaps = 34/227 (14%)
Query: 647 LPPPEWGWRTASHGDLIR--------GTVLTYQCEPG------YELLGSDILTCQWDLS- 691
LPP T ++GD I G+V+TY+C PG +EL+G + C +
Sbjct: 618 LPP------TIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 671
Query: 692 ---WSAAPPACQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPGYSLEGAAMLTC 747
WS P C C P + NG + + F + V++RC PG+ ++G + C
Sbjct: 672 VGIWSGPAPQCIIPNKCTPPN-VENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 730
Query: 748 YSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIG 807
+ + KW +P C+ +P P V K ++ G+ + + C G++L G
Sbjct: 731 QALN----KWEPELPSCSRVCQP--PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG 784
Query: 808 EVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLPLG 854
++ C P W+ P C+V D QL G + + L LG
Sbjct: 785 AASMRCTP--QGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLG 829
Score = 79.3 bits (194), Expect = 1e-14
Identities = 60/227 (26%), Positives = 97/227 (42%), Gaps = 34/227 (14%)
Query: 647 LPPPEWGWRTASHGDLIR--------GTVLTYQCEPG------YELLGSDILTCQWDLS- 691
LPP T ++GD I G+V+TY+C PG +EL+G + C +
Sbjct: 1068 LPP------TIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 1121
Query: 692 ---WSAAPPACQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPGYSLEGAAMLTC 747
WS P C C P + NG + + F + V++RC PG+ ++G + C
Sbjct: 1122 VGIWSGPAPQCIIPNKCTPPN-VENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 1180
Query: 748 YSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIG 807
+ + KW +P C+ +P P V K ++ G+ + + C G++L G
Sbjct: 1181 QALN----KWEPELPSCSRVCQP--PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG 1234
Query: 808 EVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLPLG 854
++ C P W+ P C+V D QL G + + L LG
Sbjct: 1235 AASMRCTP--QGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLG 1279
Score = 78.2 bits (191), Expect = 3e-14
Identities = 65/255 (25%), Positives = 109/255 (42%), Gaps = 42/255 (16%)
Query: 647 LPPPEWGWRTASHGDLIR--------GTVLTYQCEPG------YELLGSDILTCQWDLS- 691
LPP T ++GD I G+V+TY+C G +EL+G + C +
Sbjct: 1518 LPP------TIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQ 1571
Query: 692 ---WSAAPPACQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPGYSLEGAAMLTC 747
WS P C C P + NG + + F + V++RC PG+ ++G + C
Sbjct: 1572 VGIWSGPAPQCIIPNKCTPPN-VENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 1630
Query: 748 YSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIG 807
+ + KW +P C+ +P P + + ++ ++ G+ + + C G++L G
Sbjct: 1631 QALN----KWEPELPSCSRVCQP--PPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRG 1684
Query: 808 EVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYY 867
++ C P W+ + P C V D QL G +L PL L + G + +
Sbjct: 1685 AASLHCTP--QGDWSPEAPRCAVKSCDDFLGQLPHGR----VLFPLNLQL----GAKVSF 1734
Query: 868 TKLQGKSLFGFSGSH 882
+G L G S SH
Sbjct: 1735 VCDEGFRLKGSSVSH 1749
Score = 74.7 bits (182), Expect = 4e-13
Identities = 95/386 (24%), Positives = 154/386 (39%), Gaps = 59/386 (15%)
Query: 484 GALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPD 542
G+ +SC GY L G +A + W++ P C + CG + G +S +
Sbjct: 124 GSQIKYSCTKGYRLI--GSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTN 181
Query: 543 WPQSYSPGQ----DCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRG 598
+++ G C G ++ ++ + I D + ++ G P + +
Sbjct: 182 -RENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 240
Query: 599 PQPRRRLLSSGP------DLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC-------P 645
P +L S + ++F+ PG FV+ + PR C P
Sbjct: 241 PNVENGILVSDNRSLFSLNEVVEFRCQPG---------FVM---KGPRRVKCQALNKWEP 288
Query: 646 ELP--------PPE--WGWRTASHGDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSA 694
ELP PP+ RT D G + Y CEPGY+L G+ + C WS
Sbjct: 289 ELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 348
Query: 695 APPACQKIMTCAD-PGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTG 753
A P C+ + +C D G++ NG R +G+ V + C G+ L+G++ C
Sbjct: 349 AAPTCE-VKSCDDFMGQLLNG-RVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 406
Query: 754 TPKWSDRVPKCALKYEPCLNPGVPENGYQT-LYKHHYQAGESLRFFC------YEGFELI 806
+ W+ VP C + C +P V NG T + G+++ + C F+LI
Sbjct: 407 S-LWNSSVPVCEQIF--CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 463
Query: 807 GEVTITCV--PGHPSQWTSQPPLCKV 830
GE TI C P W+S P C +
Sbjct: 464 GESTIRCTSDPQGNGVWSSPAPRCGI 489
Score = 72.0 bits (175), Expect = 2e-12
Identities = 130/584 (22%), Positives = 205/584 (35%), Gaps = 72/584 (12%)
Query: 305 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM----------------- 346
+L G +F CD G++L+G C L G R WN P C
Sbjct: 1725 NLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTG 1784
Query: 347 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERV-SLDEDNDRLM 405
G + + P P + NL I H V S L
Sbjct: 1785 TPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDP----HGNGVWSSPAPRCELS 1840
Query: 406 VRSGGSPL-------SPVIYDSDMDDVPERGLISDAQSLYV-ELLSETPANPLLLSLRFE 457
VR+G SP I +D + L + + Y ++ S + L+ S +
Sbjct: 1841 VRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVED 1900
Query: 458 AFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWN 517
C P + + + + G+ +SC G+ L G P+ V W+
Sbjct: 1901 NCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLI--GSPSTTCLVSGNNVTWD 1958
Query: 518 DTEPACKAMCGGELSEPAGVVLSPDWPQ----SYSPGQDCVWGVHVQEEKRILLQV---- 569
P C+ + EP + + D+ S+ G + H + L ++
Sbjct: 1959 KKAPICEIIS----CEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGER 2014
Query: 570 EILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP----DLT--LQFQAPPGPP 623
I + D + ++ P + P+ + G LT ++F+ PG
Sbjct: 2015 SIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFV 2074
Query: 624 NPGLGQ-GFVLHFKEVPRNDTCPEL--PPPE--WGWRTASHGDLIR-GTVLTYQCEPGYE 677
G + + P+ C + PPPE G T SH D G + Y CEP Y+
Sbjct: 2075 MVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYD 2134
Query: 678 LLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRTASDAGFPVGSHVQYRCLPG 736
L G+ L C WS P C + +C D G++ +G R +G+ V + C G
Sbjct: 2135 LRGAASLHCTPQGDWSPEAPRC-TVKSCDDFLGQLPHG-RVLLPLNLQLGAKVSFVCDEG 2192
Query: 737 YSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKH-HYQAGESL 795
+ L+G + C W+ VP C + C NP NG T G+ +
Sbjct: 2193 FRLKGRSASHCVLAGM-KALWNSSVPVCEQIF--CPNPPAILNGRHTGTPFGDIPYGKEI 2249
Query: 796 RFFCYE------GFELIGEVTITCV--PGHPSQWTSQPPLCKVT 831
+ C F LIGE +I C P W+S P C+++
Sbjct: 2250 SYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELS 2293
Score = 70.1 bits (170), Expect = 9e-12
Identities = 63/237 (26%), Positives = 93/237 (39%), Gaps = 26/237 (10%)
Query: 619 PPGPPNPGL----GQGFVLHFKEVPRNDTCPELPPPEW-----GWRTASHGDLIRGTVLT 669
P GPP PGL G + + + PEW + GT L
Sbjct: 11 PVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLN 70
Query: 670 YQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHV 729
Y+C PGY I+ C + W+ A C++ +C +P + NG G GS +
Sbjct: 71 YECRPGYSGRPFSII-CLKNSVWTGAKDRCRR-KSCRNPPDPVNG-MVHVIKGIQFGSQI 127
Query: 730 QYRCLPGYSLEGAAMLTC-YSRDTGTPKWSDRVPKCALKYEPC-LNPGVPENGYQTLYKH 787
+Y C GY L G++ TC S DT W + P C PC L P + + + +
Sbjct: 128 KYSCTKGYRLIGSSSATCIISGDTVI--WDNETPIC--DRIPCGLPPTITNGDFISTNRE 183
Query: 788 HYQAGESLRFFCYEG------FELIGEVTITCVPGHPSQ--WTSQPPLCKVTQTTDP 836
++ G + + C G FEL+GE +I C W+ P C + P
Sbjct: 184 NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 240
Score = 66.2 bits (160), Expect = 1e-10
Identities = 48/184 (26%), Positives = 77/184 (41%), Gaps = 15/184 (8%)
Query: 665 GTVLTYQCEPGYELLGSDILTCQ---WDLSWSAAPPACQKIMTCADPGEIANGHRTASDA 721
G +++ C+ G+ L G C W+++ P C++I C +P I NG T +
Sbjct: 2182 GAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIF-CPNPPAILNGRHTGTPF 2240
Query: 722 G-FPVGSHVQYRCLPG------YSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEP-CLN 773
G P G + Y C ++L G + + C S G WS P+C L C +
Sbjct: 2241 GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPH 2300
Query: 774 PGVPENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQ 832
P +NG Y + Y G ++ + C G+ L+G+ I C W+ CK
Sbjct: 2301 PPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCT--DQGIWSQLDHYCKEVN 2358
Query: 833 TTDP 836
+ P
Sbjct: 2359 CSFP 2362
Score = 52.4 bits (124), Expect = 2e-06
Identities = 37/135 (27%), Positives = 57/135 (42%), Gaps = 9/135 (6%)
Query: 644 CPELPPPEWGWRTASHGDL-IRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 702
CP P + G H L + G ++Y C+PGY L+G + C WS C+++
Sbjct: 2298 CPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEV 2357
Query: 703 MTCADPGEIANG--HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 760
C+ P NG + G +V +C GY+LEG+ C + D +W
Sbjct: 2358 -NCSFP-LFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADD----RWDPP 2411
Query: 761 VPKCALKYEPCLNPG 775
+ KC + L G
Sbjct: 2412 LAKCTSRTHDALIVG 2426
Score = 50.8 bits (120), Expect = 6e-06
Identities = 74/282 (26%), Positives = 114/282 (40%), Gaps = 40/282 (14%)
Query: 289 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 346
SC PP P +G V V TD+ G + C +G++L G + C L+G W+ + P C
Sbjct: 1453 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1512
Query: 347 -ASCG--GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS-----LD 398
CG TI N I + G +T R + + GR++ FE V
Sbjct: 1513 RIPCGLPPTIANGDF--ISTNRENFHYGSVVTYRCNL-GSRGRKV---FELVGEPSIYCT 1566
Query: 399 EDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-----VE------LLSETPA 447
++D++ + SG +P + +V L+SD +SL+ VE + + P
Sbjct: 1567 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 1626
Query: 448 NPLLLSLRFEAFEEDRCF-----APFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPG 501
+L E C P + HG T + + + PG +SC PGY L
Sbjct: 1627 RVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAA 1686
Query: 502 PPNAIECVDPTEPHWNDTEPACKA-MCGGELSE-PAGVVLSP 541
++ C + W+ P C C L + P G VL P
Sbjct: 1687 ---SLHCT--PQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFP 1723
Score = 46.6 bits (109), Expect = 1e-04
Identities = 24/64 (37%), Positives = 36/64 (56%), Gaps = 3/64 (4%)
Query: 289 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSC- 345
SCG PP P +G V + TD G T + C+ G++L G + CL +G +W+ + P C
Sbjct: 1906 SCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICE 1965
Query: 346 MASC 349
+ SC
Sbjct: 1966 IISC 1969
Score = 41.2 bits (95), Expect = 0.004
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 11/87 (12%)
Query: 288 LSCGFPPRPAHGDVSVT---DLHPGGTATFHCDSG------YQLQGEETLICLNGTRP-- 336
+ CG PP A+GD T + H G T+ C+ G ++L GE ++ C +
Sbjct: 614 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 673
Query: 337 SWNGETPSCMASCGGTIHNATLGRIVS 363
W+G P C+ T N G +VS
Sbjct: 674 IWSGPAPQCIIPNKCTPPNVENGILVS 700
Score = 41.2 bits (95), Expect = 0.004
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 11/87 (12%)
Query: 288 LSCGFPPRPAHGDVSVT---DLHPGGTATFHCDSG------YQLQGEETLICLNGTRP-- 336
+ CG PP A+GD T + H G T+ C+ G ++L GE ++ C +
Sbjct: 1064 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 1123
Query: 337 SWNGETPSCMASCGGTIHNATLGRIVS 363
W+G P C+ T N G +VS
Sbjct: 1124 IWSGPAPQCIIPNKCTPPNVENGILVS 1150
Score = 40.8 bits (94), Expect = 0.006
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 11/87 (12%)
Query: 288 LSCGFPPRPAHGDVSVT---DLHPGGTATFHCDSG------YQLQGEETLICLNGTRP-- 336
+ CG PP A+GD T + H G T+ C+ G ++L GE ++ C +
Sbjct: 1514 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVG 1573
Query: 337 SWNGETPSCMASCGGTIHNATLGRIVS 363
W+G P C+ T N G +VS
Sbjct: 1574 IWSGPAPQCIIPNKCTPPNVENGILVS 1600
>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
Length = 2039
Score = 104 bits (260), Expect = 3e-22
Identities = 149/630 (23%), Positives = 229/630 (36%), Gaps = 120/630 (19%)
Query: 290 CGFPPRPAHGDVSVT---DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC- 345
C PP HG+ + + + PG + C+ GY L+G +L C + W+ E P C
Sbjct: 1197 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCT--PQGDWSPEAPRCA 1254
Query: 346 MASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRL------HLHF------- 392
+ SC + GR++ P + L + EG RL H
Sbjct: 1255 VKSCDDFLGQLPHGRVLFP-----LNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLW 1309
Query: 393 -------ERVSLDEDNDRLMVRSGGSPLSPVIYDSDM----DDVPERGL---------IS 432
E + L R G+P + Y ++ D P+RG+ I
Sbjct: 1310 NNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIR 1369
Query: 433 DAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCL 492
+ + +PA LS+R + F PF A + D E+ G + C
Sbjct: 1370 CTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQF-PF-ASPTIPINDFEFPVGTSLNYECR 1427
Query: 493 PGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSY----- 547
PGY G +I C++ W+ E C+ G EP ++ + +
Sbjct: 1428 PGYF----GKMFSISCLENLV--WSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVN 1481
Query: 548 -----------SPGQDC-VWGVHVQEEKRILLQVEILNVR-------------------E 576
SP C V G +V +K+ + EI++
Sbjct: 1482 YSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPI-CEIISCEPPPTISNGDFYSNNRTSFHN 1540
Query: 577 GDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFK 636
G ++T GP L +L G R + + D + + P P +
Sbjct: 1541 GTVVTYQCHTGPDGEQLFELVG---ERSIYCTSKDDQVGVWSSPPP-------------R 1584
Query: 637 EVPRND-TCPELPPPEWGWRTASHGDLIRGT-VLTYQCEPGYELLGSDILTCQWDLSWSA 694
+ N T PE+ E R + T ++ ++C+PG+ ++GS + CQ + W
Sbjct: 1585 CISTNKCTAPEV---ENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGP 1641
Query: 695 APPACQKIMTCADPGEIANGHRTAS-DAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTG 753
P C ++ C P EI +G T S F G V Y C P Y L GAA L C T
Sbjct: 1642 KLPHCSRV--CQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHC----TP 1695
Query: 754 TPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC 813
WS P+C +K +P + L + Q G + F C EGF L G C
Sbjct: 1696 QGDWSPEAPRCTVKSCDDFLGQLPHG--RVLLPLNLQLGAKVSFVCDEGFRLKGRSASHC 1753
Query: 814 V-PGHPSQWTSQPPLCKVTQTTDPSRQLEG 842
V G + W S P+C+ +P L G
Sbjct: 1754 VLAGMKALWNSSVPVCEQIFCPNPPAILNG 1783
Score = 87.4 bits (215), Expect = 5e-17
Identities = 143/603 (23%), Positives = 229/603 (37%), Gaps = 113/603 (18%)
Query: 305 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC---MASCGGTIHNAT-LG 359
+L G F CD G+QL+G C L G WN P C I N G
Sbjct: 825 NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTG 884
Query: 360 RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYD 419
+ + P G N TC H +R + + +R P ++
Sbjct: 885 KPLEVFPFGKA-VNYTC------------DPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 931
Query: 420 SDMDDVPERGLISDAQS----LYVELLSETPAN--PLLLSLRFEAFEE--DRCFAPFLAH 471
S P G++ Q+ L+ +L ++T A+ P+ SL++E E R F+
Sbjct: 932 SP---APRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 988
Query: 472 GNV--------------TTTDP---------EYRPGALATFSCLPGYALEPPGPPNAIEC 508
V T DP + + G+ +SC G+ L ++ EC
Sbjct: 989 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH---SSAEC 1045
Query: 509 V-DPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRIL 566
+ HW+ P C+ + CG + G +S + +++ G + ++ R +
Sbjct: 1046 ILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTN-RENFHYGSVVTYRCNLGSRGRKV 1104
Query: 567 LQV----EILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP------DLTLQF 616
++ I D + ++ G P + + P +L S + ++F
Sbjct: 1105 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 1164
Query: 617 QAPPGPPNPGLGQGFVLHFKEVPRNDTC-------PELP--------PPE--WGWRTASH 659
+ PG FV+ + PR C PELP PPE G T SH
Sbjct: 1165 RCQPG---------FVM---KGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSH 1212
Query: 660 GDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRT 717
D G + Y CEPGY+L G+ L C WS P C + +C D G++ +G R
Sbjct: 1213 QDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC-AVKSCDDFLGQLPHG-RV 1270
Query: 718 ASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVP 777
+G+ V + C G+ L+G+++ C + W++ VP C ++ C NP
Sbjct: 1271 LFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRS-LWNNSVPVC--EHIFCPNPPAI 1327
Query: 778 ENGYQT-LYKHHYQAGESLRFFCYE------GFELIGEVTITCV--PGHPSQWTSQPPLC 828
NG T G+ + + C F LIGE TI C P W+S P C
Sbjct: 1328 LNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRC 1387
Query: 829 KVT 831
+++
Sbjct: 1388 ELS 1390
Score = 87.0 bits (214), Expect = 7e-17
Identities = 142/602 (23%), Positives = 228/602 (37%), Gaps = 113/602 (18%)
Query: 305 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC---MASCGGTIHNAT-LG 359
+L G F CD G+QL+G C L G WN P C I N G
Sbjct: 375 NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTG 434
Query: 360 RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYD 419
+ + P G N TC H +R + + +R P ++
Sbjct: 435 KPLEVFPFGKT-VNYTC------------DPHPDRGTSFDLIGESTIRCTSDPQGNGVWS 481
Query: 420 SDMDDVPERGLISDAQS----LYVELLSETPAN--PLLLSLRFEAFEE--DRCFAPFLAH 471
S P G++ Q+ L+ +L ++T A+ P+ SL++E E R F+
Sbjct: 482 SP---APRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLD 538
Query: 472 GNV--------------TTTDP---------EYRPGALATFSCLPGYALEPPGPPNAIEC 508
V T DP + + G+ +SC G+ L ++ EC
Sbjct: 539 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH---SSAEC 595
Query: 509 V-DPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQ----DCVWGVHVQEE 562
+ HW+ P C+ + CG + G +S + +++ G C G ++
Sbjct: 596 ILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTN-RENFHYGSVVTYRCNPGSGGRKV 654
Query: 563 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP------DLTLQF 616
++ + I D + ++ G P + + P +L S + ++F
Sbjct: 655 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 714
Query: 617 QAPPGPPNPGLGQGFVLHFKEVPRNDTC-------PELP--------PPE--WGWRTASH 659
+ PG FV+ + PR C PELP PP+ RT
Sbjct: 715 RCQPG---------FVM---KGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRD 762
Query: 660 GDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRT 717
D G + Y CEPGY+L G+ + C WS A P C+ + +C D G++ NG R
Sbjct: 763 KDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE-VKSCDDFMGQLLNG-RV 820
Query: 718 ASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVP 777
+G+ V + C G+ L+G++ C + W+ VP C + C +P V
Sbjct: 821 LFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES-LWNSSVPVCEQIF--CPSPPVI 877
Query: 778 ENGYQT-LYKHHYQAGESLRFFC------YEGFELIGEVTITCV--PGHPSQWTSQPPLC 828
NG T + G+++ + C F+LIGE TI C P W+S P C
Sbjct: 878 PNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC 937
Query: 829 KV 830
+
Sbjct: 938 GI 939
Score = 85.5 bits (210), Expect = 2e-16
Identities = 67/254 (26%), Positives = 109/254 (42%), Gaps = 41/254 (16%)
Query: 648 PPPEWGWRTASHGDLI--------RGTVLTYQCEPG------YELLGSDILTCQWDLS-- 691
PPP T S+GD GTV+TYQC G +EL+G + C
Sbjct: 1521 PPP-----TISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQV 1575
Query: 692 --WSAAPPACQKIMTCADPGEIANGHRTASDAGF-PVGSHVQYRCLPGYSLEGAAMLTCY 748
WS+ PP C C P E+ N R + F + +++RC PG+ + G+ + C
Sbjct: 1576 GVWSSPPPRCISTNKCTAP-EVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQ 1634
Query: 749 SRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGE 808
+ +W ++P C+ +P P + + ++ ++ G+ + + C ++L G
Sbjct: 1635 TNG----RWGPKLPHCSRVCQP--PPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGA 1688
Query: 809 VTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYT 868
++ C P W+ + P C V D QL G +LLPL L + G + +
Sbjct: 1689 ASLHCTP--QGDWSPEAPRCTVKSCDDFLGQLPHGR----VLLPLNLQL----GAKVSFV 1738
Query: 869 KLQGKSLFGFSGSH 882
+G L G S SH
Sbjct: 1739 CDEGFRLKGRSASH 1752
Score = 81.3 bits (199), Expect = 4e-15
Identities = 136/577 (23%), Positives = 213/577 (36%), Gaps = 103/577 (17%)
Query: 289 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 346
SC PP P +G V V TD+ G + C +G++L G + C L+G W+ + P C
Sbjct: 553 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
Query: 347 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS-----LDEDN 401
G G +S ++ + GR++ FE V ++
Sbjct: 613 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKV---FELVGEPSIYCTSND 669
Query: 402 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-----VE------LLSETPANPL 450
D++ + SG +P + +V L+SD +SL+ VE + + P
Sbjct: 670 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 729
Query: 451 LLSLRFEAFEEDRCF-----APFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPN 504
+L E C P + H T D + + PG +SC PGY L
Sbjct: 730 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA--- 786
Query: 505 AIECVDPTEPHWNDTEPACKA-MCGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEE 562
++ C + W+ P C+ C + + G VL P V++Q
Sbjct: 787 SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP---------------VNLQLG 829
Query: 563 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGP 622
++ + EG L G S VLA + L +S + Q P P
Sbjct: 830 AKVDFVCD-----EGFQL---KGSSASYCVLAGMES------LWNSSVPVCEQIFCPSPP 875
Query: 623 PNP-GLGQGFVLHFKEVPR--NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL 679
P G G L + N TC P P+ RGT ++L+
Sbjct: 876 VIPNGRHTGKPLEVFPFGKAVNYTCD--PHPD------------RGT--------SFDLI 913
Query: 680 GSDILTCQWDLS----WSAAPPACQKIMTCADPGE--IANGHRTASDAGFPVGSHVQYRC 733
G + C D WS+ P C + C P A + + FP+G+ ++Y C
Sbjct: 914 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 973
Query: 734 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGE 793
P Y +TC WS PK K + C P P NG + Q G
Sbjct: 974 RPEY-YGRPFSITCLDNLV----WSS--PKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGS 1025
Query: 794 SLRFFCYEGFELIGEVTITCV-PGHPSQWTSQPPLCK 829
+ + C G LIG + C+ G+ + W+++PP+C+
Sbjct: 1026 RINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1062
Score = 80.9 bits (198), Expect = 5e-15
Identities = 64/242 (26%), Positives = 102/242 (42%), Gaps = 33/242 (13%)
Query: 632 VLHFKEVPRNDTCPELPPPEWGWRTASHGDLIR--------GTVLTYQCEPG------YE 677
V+ E P D P PP T ++GD I G+V+TY+C PG +E
Sbjct: 152 VIWDNETPICDRIPCGLPP-----TITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFE 206
Query: 678 LLGSDILTCQWDLS----WSAAPPACQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYR 732
L+G + C + WS P C C P + NG + + F + V++R
Sbjct: 207 LVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPN-VENGILVSDNRSLFSLNEVVEFR 265
Query: 733 CLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAG 792
C PG+ ++G + C + + KW +P C+ +P P V K ++ G
Sbjct: 266 CQPGFVMKGPRRVKCQALN----KWEPELPSCSRVCQP--PPDVLHAERTQRDKDNFSPG 319
Query: 793 ESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLP 852
+ + + C G++L G ++ C P W+ P C+V D QL G + + L
Sbjct: 320 QEVFYSCEPGYDLRGAASMRCTP--QGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQ 377
Query: 853 LG 854
LG
Sbjct: 378 LG 379
Score = 80.5 bits (197), Expect = 7e-15
Identities = 137/577 (23%), Positives = 212/577 (36%), Gaps = 103/577 (17%)
Query: 289 SCGFPPRPAHGDVSVTD-LHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 346
SC PP P +G V V + G + C GY+L G + C ++G W+ ETP C
Sbjct: 103 SCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICD 162
Query: 347 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS-----LDEDN 401
G T G +S ++ + GR++ FE V ++
Sbjct: 163 RIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKV---FELVGEPSIYCTSND 219
Query: 402 DRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-----VE------LLSETPANPL 450
D++ + SG +P + +V L+SD +SL+ VE + + P
Sbjct: 220 DQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 279
Query: 451 LLSLRFEAFEEDRCF-----APFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPN 504
+L E C P + H T D + + PG +SC PGY L
Sbjct: 280 CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA--- 336
Query: 505 AIECVDPTEPHWNDTEPACKA-MCGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEE 562
++ C + W+ P C+ C + + G VL P V++Q
Sbjct: 337 SMRCT--PQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFP---------------VNLQLG 379
Query: 563 KRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGP 622
++ + EG L G S VLA + L +S + Q P P
Sbjct: 380 AKVDFVCD-----EGFQL---KGSSASYCVLAGMES------LWNSSVPVCEQIFCPSPP 425
Query: 623 PNP-GLGQGFVLHFKEVPR--NDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELL 679
P G G L + N TC P P+ RGT ++L+
Sbjct: 426 VIPNGRHTGKPLEVFPFGKTVNYTCD--PHPD------------RGT--------SFDLI 463
Query: 680 GSDILTCQWDLS----WSAAPPACQKIMTCADPGE--IANGHRTASDAGFPVGSHVQYRC 733
G + C D WS+ P C + C P A + + FP+G+ ++Y C
Sbjct: 464 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 523
Query: 734 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGE 793
P Y +TC WS PK K + C P P NG + Q G
Sbjct: 524 RPEY-YGRPFSITCLDNLV----WSS--PKDVCKRKSCKTPPDPVNGMVHVIT-DIQVGS 575
Query: 794 SLRFFCYEGFELIGEVTITCV-PGHPSQWTSQPPLCK 829
+ + C G LIG + C+ G+ + W+++PP+C+
Sbjct: 576 RINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
Score = 79.3 bits (194), Expect = 1e-14
Identities = 60/227 (26%), Positives = 97/227 (42%), Gaps = 34/227 (14%)
Query: 647 LPPPEWGWRTASHGDLIR--------GTVLTYQCEPG------YELLGSDILTCQWDLS- 691
LPP T ++GD I G+V+TY+C PG +EL+G + C +
Sbjct: 618 LPP------TIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 671
Query: 692 ---WSAAPPACQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPGYSLEGAAMLTC 747
WS P C C P + NG + + F + V++RC PG+ ++G + C
Sbjct: 672 VGIWSGPAPQCIIPNKCTPPN-VENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 730
Query: 748 YSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIG 807
+ + KW +P C+ +P P V K ++ G+ + + C G++L G
Sbjct: 731 QALN----KWEPELPSCSRVCQP--PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG 784
Query: 808 EVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLPLG 854
++ C P W+ P C+V D QL G + + L LG
Sbjct: 785 AASMRCTP--QGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLG 829
Score = 78.2 bits (191), Expect = 3e-14
Identities = 65/255 (25%), Positives = 109/255 (42%), Gaps = 42/255 (16%)
Query: 647 LPPPEWGWRTASHGDLIR--------GTVLTYQCEPG------YELLGSDILTCQWDLS- 691
LPP T ++GD I G+V+TY+C G +EL+G + C +
Sbjct: 1068 LPP------TIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQ 1121
Query: 692 ---WSAAPPACQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPGYSLEGAAMLTC 747
WS P C C P + NG + + F + V++RC PG+ ++G + C
Sbjct: 1122 VGIWSGPAPQCIIPNKCTPPN-VENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC 1180
Query: 748 YSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIG 807
+ + KW +P C+ +P P + + ++ ++ G+ + + C G++L G
Sbjct: 1181 QALN----KWEPELPSCSRVCQP--PPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRG 1234
Query: 808 EVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYY 867
++ C P W+ + P C V D QL G +L PL L + G + +
Sbjct: 1235 AASLHCTP--QGDWSPEAPRCAVKSCDDFLGQLPHGR----VLFPLNLQL----GAKVSF 1284
Query: 868 TKLQGKSLFGFSGSH 882
+G L G S SH
Sbjct: 1285 VCDEGFRLKGSSVSH 1299
Score = 74.7 bits (182), Expect = 4e-13
Identities = 95/386 (24%), Positives = 154/386 (39%), Gaps = 59/386 (15%)
Query: 484 GALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPD 542
G+ +SC GY L G +A + W++ P C + CG + G +S +
Sbjct: 124 GSQIKYSCTKGYRLI--GSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFISTN 181
Query: 543 WPQSYSPGQ----DCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRG 598
+++ G C G ++ ++ + I D + ++ G P + +
Sbjct: 182 -RENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 240
Query: 599 PQPRRRLLSSGP------DLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTC-------P 645
P +L S + ++F+ PG FV+ + PR C P
Sbjct: 241 PNVENGILVSDNRSLFSLNEVVEFRCQPG---------FVM---KGPRRVKCQALNKWEP 288
Query: 646 ELP--------PPE--WGWRTASHGDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSA 694
ELP PP+ RT D G + Y CEPGY+L G+ + C WS
Sbjct: 289 ELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 348
Query: 695 APPACQKIMTCAD-PGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTG 753
A P C+ + +C D G++ NG R +G+ V + C G+ L+G++ C
Sbjct: 349 AAPTCE-VKSCDDFMGQLLNG-RVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME 406
Query: 754 TPKWSDRVPKCALKYEPCLNPGVPENGYQT-LYKHHYQAGESLRFFC------YEGFELI 806
+ W+ VP C + C +P V NG T + G+++ + C F+LI
Sbjct: 407 S-LWNSSVPVCEQIF--CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 463
Query: 807 GEVTITCV--PGHPSQWTSQPPLCKV 830
GE TI C P W+S P C +
Sbjct: 464 GESTIRCTSDPQGNGVWSSPAPRCGI 489
Score = 72.0 bits (175), Expect = 2e-12
Identities = 130/584 (22%), Positives = 205/584 (35%), Gaps = 72/584 (12%)
Query: 305 DLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM----------------- 346
+L G +F CD G++L+G C L G R WN P C
Sbjct: 1275 NLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTG 1334
Query: 347 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERV-SLDEDNDRLM 405
G + + P P + NL I H V S L
Sbjct: 1335 TPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDP----HGNGVWSSPAPRCELS 1390
Query: 406 VRSGGSPL-------SPVIYDSDMDDVPERGLISDAQSLYV-ELLSETPANPLLLSLRFE 457
VR+G SP I +D + L + + Y ++ S + L+ S +
Sbjct: 1391 VRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVED 1450
Query: 458 AFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWN 517
C P + + + + G+ +SC G+ L G P+ V W+
Sbjct: 1451 NCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLI--GSPSTTCLVSGNNVTWD 1508
Query: 518 DTEPACKAMCGGELSEPAGVVLSPDWPQ----SYSPGQDCVWGVHVQEEKRILLQV---- 569
P C+ + EP + + D+ S+ G + H + L ++
Sbjct: 1509 KKAPICEIIS----CEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGER 1564
Query: 570 EILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP----DLT--LQFQAPPGPP 623
I + D + ++ P + P+ + G LT ++F+ PG
Sbjct: 1565 SIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFV 1624
Query: 624 NPGLGQ-GFVLHFKEVPRNDTCPEL--PPPE--WGWRTASHGDLIR-GTVLTYQCEPGYE 677
G + + P+ C + PPPE G T SH D G + Y CEP Y+
Sbjct: 1625 MVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYD 1684
Query: 678 LLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEIANGHRTASDAGFPVGSHVQYRCLPG 736
L G+ L C WS P C + +C D G++ +G R +G+ V + C G
Sbjct: 1685 LRGAASLHCTPQGDWSPEAPRC-TVKSCDDFLGQLPHG-RVLLPLNLQLGAKVSFVCDEG 1742
Query: 737 YSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKH-HYQAGESL 795
+ L+G + C W+ VP C + C NP NG T G+ +
Sbjct: 1743 FRLKGRSASHCVLAGM-KALWNSSVPVCEQIF--CPNPPAILNGRHTGTPFGDIPYGKEI 1799
Query: 796 RFFCYE------GFELIGEVTITCV--PGHPSQWTSQPPLCKVT 831
+ C F LIGE +I C P W+S P C+++
Sbjct: 1800 SYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELS 1843
Score = 70.1 bits (170), Expect = 9e-12
Identities = 63/237 (26%), Positives = 93/237 (39%), Gaps = 26/237 (10%)
Query: 619 PPGPPNPGL----GQGFVLHFKEVPRNDTCPELPPPEW-----GWRTASHGDLIRGTVLT 669
P GPP PGL G + + + PEW + GT L
Sbjct: 11 PVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDEFEFPIGTYLN 70
Query: 670 YQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHV 729
Y+C PGY I+ C + W+ A C++ +C +P + NG G GS +
Sbjct: 71 YECRPGYSGRPFSII-CLKNSVWTGAKDRCRR-KSCRNPPDPVNG-MVHVIKGIQFGSQI 127
Query: 730 QYRCLPGYSLEGAAMLTC-YSRDTGTPKWSDRVPKCALKYEPC-LNPGVPENGYQTLYKH 787
+Y C GY L G++ TC S DT W + P C PC L P + + + +
Sbjct: 128 KYSCTKGYRLIGSSSATCIISGDTVI--WDNETPIC--DRIPCGLPPTITNGDFISTNRE 183
Query: 788 HYQAGESLRFFCYEG------FELIGEVTITCVPGHPSQ--WTSQPPLCKVTQTTDP 836
++ G + + C G FEL+GE +I C W+ P C + P
Sbjct: 184 NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP 240
Score = 66.2 bits (160), Expect = 1e-10
Identities = 48/184 (26%), Positives = 77/184 (41%), Gaps = 15/184 (8%)
Query: 665 GTVLTYQCEPGYELLGSDILTCQ---WDLSWSAAPPACQKIMTCADPGEIANGHRTASDA 721
G +++ C+ G+ L G C W+++ P C++I C +P I NG T +
Sbjct: 1732 GAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIF-CPNPPAILNGRHTGTPF 1790
Query: 722 G-FPVGSHVQYRCLPG------YSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEP-CLN 773
G P G + Y C ++L G + + C S G WS P+C L C +
Sbjct: 1791 GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPH 1850
Query: 774 PGVPENG-YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQ 832
P +NG Y + Y G ++ + C G+ L+G+ I C W+ CK
Sbjct: 1851 PPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCT--DQGIWSQLDHYCKEVN 1908
Query: 833 TTDP 836
+ P
Sbjct: 1909 CSFP 1912
Score = 52.4 bits (124), Expect = 2e-06
Identities = 37/135 (27%), Positives = 57/135 (42%), Gaps = 9/135 (6%)
Query: 644 CPELPPPEWGWRTASHGDL-IRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 702
CP P + G H L + G ++Y C+PGY L+G + C WS C+++
Sbjct: 1848 CPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEV 1907
Query: 703 MTCADPGEIANG--HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDR 760
C+ P NG + G +V +C GY+LEG+ C + D +W
Sbjct: 1908 -NCSFP-LFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADD----RWDPP 1961
Query: 761 VPKCALKYEPCLNPG 775
+ KC + L G
Sbjct: 1962 LAKCTSRTHDALIVG 1976
Score = 50.8 bits (120), Expect = 6e-06
Identities = 74/282 (26%), Positives = 114/282 (40%), Gaps = 40/282 (14%)
Query: 289 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCM 346
SC PP P +G V V TD+ G + C +G++L G + C L+G W+ + P C
Sbjct: 1003 SCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1062
Query: 347 -ASCG--GTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVS-----LD 398
CG TI N I + G +T R + + GR++ FE V
Sbjct: 1063 RIPCGLPPTIANGDF--ISTNRENFHYGSVVTYRCNL-GSRGRKV---FELVGEPSIYCT 1116
Query: 399 EDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLY-----VE------LLSETPA 447
++D++ + SG +P + +V L+SD +SL+ VE + + P
Sbjct: 1117 SNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR 1176
Query: 448 NPLLLSLRFEAFEEDRCF-----APFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPG 501
+L E C P + HG T + + + PG +SC PGY L
Sbjct: 1177 RVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAA 1236
Query: 502 PPNAIECVDPTEPHWNDTEPACKA-MCGGELSE-PAGVVLSP 541
++ C + W+ P C C L + P G VL P
Sbjct: 1237 ---SLHCT--PQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFP 1273
Score = 46.6 bits (109), Expect = 1e-04
Identities = 24/64 (37%), Positives = 36/64 (56%), Gaps = 3/64 (4%)
Query: 289 SCGFPPRPAHGDVSV-TDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSC- 345
SCG PP P +G V + TD G T + C+ G++L G + CL +G +W+ + P C
Sbjct: 1456 SCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICE 1515
Query: 346 MASC 349
+ SC
Sbjct: 1516 IISC 1519
Score = 41.2 bits (95), Expect = 0.004
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 11/87 (12%)
Query: 288 LSCGFPPRPAHGDVSVT---DLHPGGTATFHCDSG------YQLQGEETLICLNGTRP-- 336
+ CG PP A+GD T + H G T+ C+ G ++L GE ++ C +
Sbjct: 614 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 673
Query: 337 SWNGETPSCMASCGGTIHNATLGRIVS 363
W+G P C+ T N G +VS
Sbjct: 674 IWSGPAPQCIIPNKCTPPNVENGILVS 700
Score = 40.8 bits (94), Expect = 0.006
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 11/87 (12%)
Query: 288 LSCGFPPRPAHGDVSVT---DLHPGGTATFHCDSG------YQLQGEETLICLNGTRP-- 336
+ CG PP A+GD T + H G T+ C+ G ++L GE ++ C +
Sbjct: 1064 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVG 1123
Query: 337 SWNGETPSCMASCGGTIHNATLGRIVS 363
W+G P C+ T N G +VS
Sbjct: 1124 IWSGPAPQCIIPNKCTPPNVENGILVS 1150
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 98.6 bits (244), Expect = 2e-20
Identities = 139/581 (23%), Positives = 216/581 (37%), Gaps = 98/581 (16%)
Query: 288 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMA 347
+ C P +G S TDLH G T T+ C+ G++L+G L CL W+ + PSC A
Sbjct: 2496 IECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLE--TGDWDVDAPSCNA 2553
Query: 348 SCGGTIHNATLGRIVSPEP---GGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRL 404
IH SP+P G G + + +I ++ F + +
Sbjct: 2554 -----IH------CDSPQPIENGFVEGADYSYGAII-------IYSCFPGFQVAGHAMQT 2595
Query: 405 MVRSGGSPLSPVIYDSDMD-----DVPERGLISDAQSLY------VELLSETPANPLLLS 453
SG S P D D + + D Q + +E+ TP P L
Sbjct: 2596 CEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLG 2655
Query: 454 LRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTE 513
+ +E + + T + G + +++C PGY L G P I D T
Sbjct: 2656 AVAKTWENTK--------ESPATHSSNFLYGTMVSYTCNPGYELL--GNPVLICQEDGT- 2704
Query: 514 PHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEIL 572
WN + P+C ++ C + G + + + C G H+ + L +E
Sbjct: 2705 --WNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPG-HILAGSDLRLCLENR 2761
Query: 573 NVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLT----LQFQAPPGPPNPGLG 628
+ G P ++ + P P G + T L ++ PG G
Sbjct: 2762 K---------WSGASPRCEAIS-CKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTE 2811
Query: 629 QGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQ------CEPGYELLGSD 682
+ K ++ P P + S +RG T+Q C G+ L G+
Sbjct: 2812 RRTCQDDKNWDEDE--PICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGAR 2869
Query: 683 ILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGA 742
C + SWS A P C + CA P ++ANG D GF V + C GY L GA
Sbjct: 2870 SRVCLANGSWSGATPDCVPV-RCATPPQLANGVTEGLDYGFM--KEVTFHCHEGYILHGA 2926
Query: 743 AMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE-------NGYQTLYKHHYQAGESL 795
LTC S W +P C +P +N G PE NG+ ++ H Q
Sbjct: 2927 PKLTCQS----DGNWDAEIPLC----KP-VNCGPPEDLAHGFPNGFSFIHGGHIQ----- 2972
Query: 796 RFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDP 836
+ C+ G++L G + C+ W+ P C + + P
Sbjct: 2973 -YQCFPGYKLHGNSSRRCLSN--GSWSGSSPSCLPCRCSTP 3010
Score = 95.1 bits (235), Expect = 3e-19
Identities = 58/164 (35%), Positives = 81/164 (49%), Gaps = 14/164 (8%)
Query: 668 LTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGS 727
+T+ C GY L G+ LTCQ D +W A P C K + C P ++A+G + F G
Sbjct: 2913 VTFHCHEGYILHGAPKLTCQSDGNWDAEIPLC-KPVNCGPPEDLAHGF--PNGFSFIHGG 2969
Query: 728 HVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKH 787
H+QY+C PGY L G + C S + WS P C PC P Y T+
Sbjct: 2970 HIQYQCFPGYKLHGNSSRRCLSNGS----WSGSSPSCL----PC-RCSTPVIEYGTVNGT 3020
Query: 788 HYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVT 831
+ G++ R C++GF+L+G ITC QW+S P C+ T
Sbjct: 3021 DFDCGKAARIQCFKGFKLLGLSEITCEA--DGQWSSGFPHCEHT 3062
Score = 91.3 bits (225), Expect = 4e-18
Identities = 62/234 (26%), Positives = 97/234 (41%), Gaps = 54/234 (23%)
Query: 643 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 702
+C PP E G+ +A D G+ +TYQC GY LLG + C + SW+ P+C +
Sbjct: 1689 SCGVPPPLENGFHSAD--DFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDV 1746
Query: 703 MTCA----------------------------------------DPGEIANGHRTASDAG 722
CA PG NGH +S
Sbjct: 1747 DECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGH--SSGEI 1804
Query: 723 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 782
+ VG+ V + C GY L G +TC + +W+ +P C K C P +PENG
Sbjct: 1805 YTVGAEVTFSCQEGYQLMGVTKITCLE----SGEWNHLIPYC--KAVSCGKPAIPENG-- 1856
Query: 783 TLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDP 836
+ + + G + + C +G+ L G+ +C+ S W+ PP+C+ + + P
Sbjct: 1857 CIEELAFTFGSKVTYRCNKGYTLAGDKESSCLAN--SSWSHSPPVCEPVKCSSP 1908
Score = 89.4 bits (220), Expect = 1e-17
Identities = 63/195 (32%), Positives = 86/195 (44%), Gaps = 14/195 (7%)
Query: 643 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 702
+C E P E G+ + G + V YQC PGY+ +GS + CQ + W + P
Sbjct: 2203 SCGEPPKVENGFLEHTTGRIFESEV-RYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVP 2261
Query: 703 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV- 761
+ C P I NG + F VGS VQ+ C GY L G + TC + KW+ +
Sbjct: 2262 LDCGKPPPIQNGFMKGEN--FEVGSKVQFFCNEGYELVGDSSWTCQK----SGKWNKKSN 2315
Query: 762 PKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 821
PKC C P + EN Q + K + F C EG L G + C+P QW
Sbjct: 2316 PKC--MPAKCPEPPLLEN--QLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPS--QQW 2369
Query: 822 TSQPPLCKVTQTTDP 836
P+CK+ T P
Sbjct: 2370 NDSFPVCKIVLCTPP 2384
Score = 86.7 bits (213), Expect = 9e-17
Identities = 66/233 (28%), Positives = 95/233 (40%), Gaps = 51/233 (21%)
Query: 644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM 703
CP L RTAS DL G+ + C+PG++L+G+ + C W+ P C++I
Sbjct: 1631 CPRLGGSVPHLRTASE-DLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERI- 1688
Query: 704 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 763
+C P + NG +A D F GS V Y+C GY L G + + C T W+ P
Sbjct: 1689 SCGVPPPLENGFHSADD--FYAGSTVTYQCNNGYYLLGDSRMFC----TDNGSWNGVSPS 1742
Query: 764 C-----------ALKYEPCLN----------------------------PGVPENGYQTL 784
C ++ CLN PG PENG+ +
Sbjct: 1743 CLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSS- 1801
Query: 785 YKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPS 837
Y G + F C EG++L+G ITC+ +W P CK P+
Sbjct: 1802 -GEIYTVGAEVTFSCQEGYQLMGVTKITCL--ESGEWNHLIPYCKAVSCGKPA 1851
Score = 86.7 bits (213), Expect = 9e-17
Identities = 58/191 (30%), Positives = 85/191 (44%), Gaps = 22/191 (11%)
Query: 657 ASHG-DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGH 715
A+H + + GT+++Y C PGYELLG+ +L CQ D +W+ + P+C I C P NG
Sbjct: 2669 ATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISI-ECDLPTAPENGF 2727
Query: 716 RTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC----ALKYEPC 771
++ +GS VQY C PG+ L G+ + C KWS P+C K P
Sbjct: 2728 LRFTETS--MGSAVQYSCKPGHILAGSDLRLCLE----NRKWSGASPRCEAISCKKPNPV 2781
Query: 772 LNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVT 831
+N + + Y L +Y+ C G+ L G TC W P+C
Sbjct: 2782 MNGSIKGSNYTYLSTLYYE--------CDPGYVLNGTERRTC--QDDKNWDEDEPICIPV 2831
Query: 832 QTTDPSRQLEG 842
+ P G
Sbjct: 2832 DCSSPPVSANG 2842
Score = 84.7 bits (208), Expect = 3e-16
Identities = 67/196 (34%), Positives = 83/196 (42%), Gaps = 16/196 (8%)
Query: 643 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 702
+C + PE G+ S + + YQCEPGYEL G+ CQ + WS C K
Sbjct: 3240 SCGKPESPEHGFVVGSKYTF--ESTIIYQCEPGYELEGNRERVCQENRQWSGGVAIC-KE 3296
Query: 703 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 762
C P E NG A G +V Y C GYSLEG + C T WS VP
Sbjct: 3297 TRCETPLEFLNG--KADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGT----WSHPVP 3350
Query: 763 KCALKYEPCLNPGV-PENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 821
C K PC P V PEN L + + +++ C EGF L G ITC P W
Sbjct: 3351 LC--KPNPCPVPFVIPENA--LLSEKEFYVDQNVSIKCREGFLLQGHGIITCNP--DETW 3404
Query: 822 TSQPPLCKVTQTTDPS 837
T C+ P+
Sbjct: 3405 TQTSAKCEKISCGPPA 3420
Score = 82.0 bits (201), Expect = 2e-15
Identities = 52/159 (32%), Positives = 73/159 (45%), Gaps = 14/159 (8%)
Query: 670 YQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHV 729
Y C+PG+EL+G+ C + W P C K + C P EI NG + +D + G V
Sbjct: 2464 YTCKPGFELVGNTTTLCGENGHWLGGKPTC-KAIECLKPKEILNGKFSYTDLHY--GQTV 2520
Query: 730 QYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHY 789
Y C G+ LEG + LTC T W P C + C +P ENG+ + Y
Sbjct: 2521 TYSCNRGFRLEGPSALTCLE----TGDWDVDAPSCNAIH--CDSPQPIENGF--VEGADY 2572
Query: 790 QAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLC 828
G + + C+ GF++ G TC S W+S P C
Sbjct: 2573 SYGAIIIYSCFPGFQVAGHAMQTC---EESGWSSSIPTC 2608
Score = 80.1 bits (196), Expect = 9e-15
Identities = 51/194 (26%), Positives = 88/194 (45%), Gaps = 14/194 (7%)
Query: 644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM 703
C E P G+ + S+ G ++ Y C G+ + G TC+ WS+ P C +
Sbjct: 2146 CGEPPSIMNGYASGSNYSF--GAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPV- 2202
Query: 704 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 763
+C +P ++ NG G S V+Y+C PGY G+ + C + W P
Sbjct: 2203 SCGEPPKVENGF-LEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQA----NRHWHSESPL 2257
Query: 764 CALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTS 823
+ + C P +NG+ + +++ G ++FFC EG+EL+G+ + TC +W
Sbjct: 2258 MCVPLD-CGKPPPIQNGF--MKGENFEVGSKVQFFCNEGYELVGDSSWTCQKS--GKWNK 2312
Query: 824 QP-PLCKVTQTTDP 836
+ P C + +P
Sbjct: 2313 KSNPKCMPAKCPEP 2326
Score = 76.6 bits (187), Expect = 1e-13
Identities = 50/172 (29%), Positives = 78/172 (45%), Gaps = 13/172 (7%)
Query: 665 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 724
G+ +TY+C GY L G +C + SWS +PP C+ + C+ P I NG S G
Sbjct: 1866 GSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPV-KCSSPENINNGKYILS--GLT 1922
Query: 725 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTL 784
S Y C GYSL+G +++ C T + W P C L + C P ++ T
Sbjct: 1923 YLSTASYSCDTGYSLQGPSIIEC----TASGIWDRAPPACHLVF--CGEPPAIKDAVIT- 1975
Query: 785 YKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDP 836
+++ ++ + C EG+ L G TI C+ +W+ C +P
Sbjct: 1976 -GNNFTFRNTVTYTCKEGYTLAGLDTIECLA--DGKWSRSDQQCLAVSCDEP 2024
Score = 76.6 bits (187), Expect = 1e-13
Identities = 54/176 (30%), Positives = 75/176 (42%), Gaps = 12/176 (6%)
Query: 667 VLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVG 726
V+T+ C+ G+ L G +L C W+ + P C KI+ C P I+ G S A G
Sbjct: 2344 VVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVC-KIVLCTPPPLISFGVPIPSSA-LHFG 2401
Query: 727 SHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYK 786
S V+Y C+ G+ L G + C T WS +P+C C P NG +
Sbjct: 2402 STVKYSCVGGFFLRGNSTTLCQPDGT----WSSPLPECV--PVECPQPEEIPNGIIDVQG 2455
Query: 787 HHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEG 842
Y + + + C GFEL+G T C G W P CK + P L G
Sbjct: 2456 LAYLS--TALYTCKPGFELVGNTTTLC--GENGHWLGGKPTCKAIECLKPKEILNG 2507
Score = 72.0 bits (175), Expect = 2e-12
Identities = 53/174 (30%), Positives = 73/174 (41%), Gaps = 17/174 (9%)
Query: 665 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 724
G +T+ C+ GY+L+G +TC W+ P C K ++C P NG + F
Sbjct: 1808 GAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYC-KAVSCGKPAIPENG--CIEELAFT 1864
Query: 725 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEP--CLNPGVPENGYQ 782
GS V YRC GY+L G +C + + WS P C EP C +P NG
Sbjct: 1865 FGSKVTYRCNKGYTLAGDKESSCLANSS----WSHSPPVC----EPVKCSSPENINNGKY 1916
Query: 783 TLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDP 836
L Y + S + C G+ L G I C W PP C + +P
Sbjct: 1917 ILSGLTYLSTAS--YSCDTGYSLQGPSIIECTAS--GIWDRAPPACHLVFCGEP 1966
Score = 71.2 bits (173), Expect = 4e-12
Identities = 53/179 (29%), Positives = 70/179 (39%), Gaps = 14/179 (7%)
Query: 665 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 724
G+ + Y C G+ L G+ CQ D +WS+ P C + C P EI NG G
Sbjct: 2401 GSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPV-ECPQPEEIPNG--IIDVQGLA 2457
Query: 725 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTL 784
S Y C PG+ L G C W P C K CL P NG +
Sbjct: 2458 YLSTALYTCKPGFELVGNTTTLCGENG----HWLGGKPTC--KAIECLKPKEILNGKFSY 2511
Query: 785 YKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEGG 843
HY G+++ + C GF L G +TC+ W P C P + +E G
Sbjct: 2512 TDLHY--GQTVTYSCNRGFRLEGPSALTCL--ETGDWDVDAPSCNAIHCDSP-QPIENG 2565
Score = 70.9 bits (172), Expect = 5e-12
Identities = 83/357 (23%), Positives = 132/357 (36%), Gaps = 42/357 (11%)
Query: 487 ATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAM-CGGELSEPAGVVLSPDWPQ 545
A++SC GY+L+ P + IEC W+ PAC + CG + V+ ++
Sbjct: 1927 ASYSCDTGYSLQGP---SIIECT--ASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTF 1981
Query: 546 SYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRL 605
+ C G + I + R D P + P+ RL
Sbjct: 1982 RNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPP---IVDHASPETAHRL 2038
Query: 606 --------------LSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPE 651
L+ L Q PP + HF E P + + L
Sbjct: 2039 FGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSIL---- 2094
Query: 652 WGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI-MTCADPGE 710
+ S G+V++++C G+ L S + C W+ +P + Q I + C +P
Sbjct: 2095 ---ESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPS 2151
Query: 711 IANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEP 770
I NG+ AS + + G+ V Y C G+ ++G TC T +WS +P C
Sbjct: 2152 IMNGY--ASGSNYSFGAMVAYSCNKGFYIKGEKKSTC----EATGQWSSPIPTC--HPVS 2203
Query: 771 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 827
C P ENG+ E +R+ C G++ +G C W S+ PL
Sbjct: 2204 CGEPPKVENGFLEHTTGRIFESE-VRYQCNPGYKSVGSPVFVCQANR--HWHSESPL 2257
Score = 68.6 bits (166), Expect = 3e-11
Identities = 125/591 (21%), Positives = 214/591 (36%), Gaps = 92/591 (15%)
Query: 288 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMA 347
+ C P +G ++ L TA++ CD+GY LQG + C W+ P+C
Sbjct: 1903 VKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECT--ASGIWDRAPPAC-- 1958
Query: 348 SCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVI--EAAEGRRLHLHFERVSLDEDN---D 402
H G + + G N T R + EG L LD D
Sbjct: 1959 ------HLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTL------AGLDTIECLAD 2006
Query: 403 RLMVRSGGSPLS-----PVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLS---- 453
RS L+ P I D + R L D Y N LL
Sbjct: 2007 GKWSRSDQQCLAVSCDEPPIVDHASPETAHR-LFGDIAFYYCSDGYSLADNSQLLCNAQG 2065
Query: 454 --LRFEAFEEDRCFA------PFLAHGNV-TTTDPEYRPGALATFSCLPGYALEPPGPPN 504
+ E + RC A P +++ + + + ++ G++ +F C+ G+ L
Sbjct: 2066 KWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSA--- 2122
Query: 505 AIECVDPTEPHWNDTEPACKAM---CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQE 561
IEC+ + WN + + + + CG S G ++ C G +++
Sbjct: 2123 KIECMRGGQ--WNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKG 2180
Query: 562 EKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGP----DLTLQFQ 617
EK+ + + P+ ++ P+ L + +++Q
Sbjct: 2181 EKKSTCEA----------TGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQ 2230
Query: 618 APPGPPNPGLGQGFVLHFKEVPRNDT--------CPELPPPEWGWRTASHGDLIRGTVLT 669
PG + G FV +++ C + PP + G+ + ++ G+ +
Sbjct: 2231 CNPGYKSVG-SPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEV--GSKVQ 2287
Query: 670 YQCEPGYELLGSDILTCQWDLSWS-AAPPACQKIMTCADPGEIANGHRTASDAGFPVGSH 728
+ C GYEL+G TCQ W+ + P C C +P + N + VG
Sbjct: 2288 FFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMP-AKCPEPPLLEN-QLVLKELTTEVGV- 2344
Query: 729 VQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKY---EPCLNPGVPENGYQTLY 785
V + C G+ L+G ++L C + +W+D P C + P ++ GVP +
Sbjct: 2345 VTFSCKEGHVLQGPSVLKCLP----SQQWNDSFPVCKIVLCTPPPLISFGVP------IP 2394
Query: 786 KHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDP 836
G ++++ C GF L G T C P W+S P C + P
Sbjct: 2395 SSALHFGSTVKYSCVGGFFLRGNSTTLCQP--DGTWSSPLPECVPVECPQP 2443
Score = 67.8 bits (164), Expect = 4e-11
Identities = 50/165 (30%), Positives = 72/165 (43%), Gaps = 13/165 (7%)
Query: 665 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 724
G + Y C GY L G C + +WS P C K C P I + S+ F
Sbjct: 3318 GPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLC-KPNPCPVPFVIPE-NALLSEKEFY 3375
Query: 725 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTL 784
V +V +C G+ L+G ++TC +T W+ KC + C P EN
Sbjct: 3376 VDQNVSIKCREGFLLQGHGIITCNPDET----WTQTSAKC--EKISCGPPAHVENAIARG 3429
Query: 785 YKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 829
HYQ G+ + + CY G+ L G + C+ WTS PP+C+
Sbjct: 3430 V--HYQYGDMITYSCYSGYMLEGFLRSVCLEN--GTWTS-PPICR 3469
Score = 61.2 bits (147), Expect = 4e-09
Identities = 36/125 (28%), Positives = 57/125 (45%), Gaps = 5/125 (4%)
Query: 644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM 703
CP L PPE G+ + + +C PG++L+GS I+ C + WS + C ++
Sbjct: 378 CPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYC-RVR 436
Query: 704 TCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPK 763
TC + +GH + S + C GY LEG+ LTC G +W P+
Sbjct: 437 TCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC----QGNSQWDGPEPR 492
Query: 764 CALKY 768
C ++
Sbjct: 493 CVERH 497
Score = 58.2 bits (139), Expect = 4e-08
Identities = 47/173 (27%), Positives = 68/173 (39%), Gaps = 12/173 (6%)
Query: 671 QCEPGYEL-LGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHV 729
+C GY + +D TCQ D W +C C P I H F V V
Sbjct: 3147 RCLEGYTMDTDTDTFTCQKDGRWFPERISCSP-KKCPLPENIT--HILVHGDDFSVNRQV 3203
Query: 730 QYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHY 789
C GY+ EG + C T P +SD + C P PE+G+ K+ +
Sbjct: 3204 SVSCAEGYTFEGVNISVCQLDGTWEPPFSDE----SCSPVSCGKPESPEHGFVVGSKYTF 3259
Query: 790 QAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEG 842
++ ++ + C G+EL G C QW+ +CK T+ P L G
Sbjct: 3260 ES--TIIYQCEPGYELEGNRERVCQENR--QWSGGVAICKETRCETPLEFLNG 3308
Score = 57.4 bits (137), Expect = 6e-08
Identities = 43/189 (22%), Positives = 75/189 (39%), Gaps = 14/189 (7%)
Query: 648 PPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD 707
PP + + I G + YQC PGY+L G+ C + SWS + P+C C+
Sbjct: 2951 PPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLP-CRCST 3009
Query: 708 PGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALK 767
P + T + F G + +C G+ L G + +TC +WS P C +
Sbjct: 3010 P---VIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITC----EADGQWSSGFPHC--E 3060
Query: 768 YEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPL 827
+ C + + N + + + + + C G+ + G + C W+ P+
Sbjct: 3061 HTSCGSLPMIPNAF--ISETSSWKENVITYSCRSGYVIQGSSDLICT--EKGVWSQPYPV 3116
Query: 828 CKVTQTTDP 836
C+ P
Sbjct: 3117 CEPLSCGSP 3125
Score = 56.2 bits (134), Expect = 1e-07
Identities = 24/59 (40%), Positives = 35/59 (59%), Gaps = 2/59 (3%)
Query: 288 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 346
+SCG PP +G S D + G T T+ C++GY L G+ + C + SWNG +PSC+
Sbjct: 1688 ISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTD--NGSWNGVSPSCL 1744
Score = 54.3 bits (129), Expect = 5e-07
Identities = 53/187 (28%), Positives = 71/187 (37%), Gaps = 20/187 (10%)
Query: 648 PPPEWGWRTASHGDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPP----ACQKI 702
P PE HGD ++ C GY G +I CQ D +W PP +C +
Sbjct: 3182 PLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWE--PPFSDESCSPV 3239
Query: 703 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 762
+C P +G S F S + Y+C PGY LEG C +WS V
Sbjct: 3240 -SCGKPESPEHGFVVGSKYTFE--STIIYQCEPGYELEGNRERVCQE----NRQWSGGVA 3292
Query: 763 KCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWT 822
C K C P NG + + G ++ + C G+ L G C W+
Sbjct: 3293 IC--KETRCETPLEFLNGKADI--ENRTTGPNVVYSCNRGYSLEGPSEAHCTEN--GTWS 3346
Query: 823 SQPPLCK 829
PLCK
Sbjct: 3347 HPVPLCK 3353
Score = 53.1 bits (126), Expect = 1e-06
Identities = 37/128 (28%), Positives = 51/128 (39%), Gaps = 7/128 (5%)
Query: 643 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC--Q 700
TCP L P+ G + S +++ T C+ GY L GSD LTCQ + W P C +
Sbjct: 437 TCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVER 496
Query: 701 KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGA-AMLTCYSRDTGTPKWSD 759
T P ++ G+ C G+ L G ML C T + KW+
Sbjct: 497 HCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRC----TTSGKWNV 552
Query: 760 RVPKCALK 767
V K
Sbjct: 553 GVQAAVCK 560
Score = 45.1 bits (105), Expect = 3e-04
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 9/85 (10%)
Query: 764 CALKYEPCLNPGVPENGY--QTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQW 821
C L + P L P PENGY Q +H+ A +R C+ GF+L+G I C+P W
Sbjct: 373 CELVHCPALKP--PENGYFIQNTCNNHFNAACGVR--CHPGFDLVGSSIILCLPN--GLW 426
Query: 822 TSQPPLCKVTQTTDPSRQLEGGNLA 846
+ C+V +T RQ + G+++
Sbjct: 427 SGSESYCRV-RTCPHLRQPKHGHIS 450
Score = 41.6 bits (96), Expect = 0.003
Identities = 24/64 (37%), Positives = 27/64 (42%), Gaps = 3/64 (4%)
Query: 288 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMA 347
+ C P P +G S G TF C GYQL G + CL WN P C A
Sbjct: 1787 IKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLES--GEWNHLIPYCKA 1844
Query: 348 -SCG 350
SCG
Sbjct: 1845 VSCG 1848
Score = 40.0 bits (92), Expect = 0.010
Identities = 63/257 (24%), Positives = 86/257 (33%), Gaps = 77/257 (29%)
Query: 305 DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC-MASCG------GTIHNA- 356
DL PG CD G+QL G CLN + W P C SCG H+A
Sbjct: 1647 DLKPGSKVNLFCDPGFQLVGNPVQYCLN--QGQWTQPLPHCERISCGVPPPLENGFHSAD 1704
Query: 357 -----------------TLG--RIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSL 397
LG R+ + G G + +C V E A G H +++
Sbjct: 1705 DFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNV 1764
Query: 398 DEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFE 457
D GS + + P G D ++ + + P NP
Sbjct: 1765 D-----------GSYICSCV-------PPYTG---DGKNCAEPIKCKAPGNP-------- 1795
Query: 458 AFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWN 517
N ++ Y GA TFSC GY L I C++ E WN
Sbjct: 1796 --------------ENGHSSGEIYTVGAEVTFSCQEGYQLM---GVTKITCLESGE--WN 1836
Query: 518 DTEPACKAMCGGELSEP 534
P CKA+ G+ + P
Sbjct: 1837 HLIPYCKAVSCGKPAIP 1853
Score = 39.3 bits (90), Expect = 0.017
Identities = 19/58 (32%), Positives = 27/58 (46%), Gaps = 2/58 (3%)
Query: 288 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 345
+SCG P P +G + G T+ C+ GY L G++ CL SW+ P C
Sbjct: 1845 VSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCL--ANSSWSHSPPVC 1900
Score = 38.5 bits (88), Expect = 0.029
Identities = 18/58 (31%), Positives = 27/58 (46%), Gaps = 2/58 (3%)
Query: 288 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 345
+SCG P P HG V + T + C+ GY+L+G +C + W+G C
Sbjct: 3239 VSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQ--WSGGVAIC 3294
Score = 37.0 bits (84), Expect = 0.084
Identities = 18/60 (30%), Positives = 31/60 (51%), Gaps = 4/60 (6%)
Query: 289 SCGFPPRPAHGDVSVT--DLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 346
+C +P HG +S + ++ T CD GY+L+G + L C ++ W+G P C+
Sbjct: 437 TCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQ--WDGPEPRCV 494
Score = 36.6 bits (83), Expect = 0.11
Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 6/80 (7%)
Query: 275 RGGGFR---IHYQAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL 331
RGG + + Q + CG PP +G S ++ G + C+ G+ ++GE+ C
Sbjct: 2128 RGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTC- 2186
Query: 332 NGTRPSWNGETPSC-MASCG 350
W+ P+C SCG
Sbjct: 2187 -EATGQWSSPIPTCHPVSCG 2205
Score = 36.6 bits (83), Expect = 0.11
Identities = 22/63 (34%), Positives = 28/63 (44%), Gaps = 3/63 (4%)
Query: 289 SCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC-MA 347
SCG P + +S T T+ C SGY +QG LIC + W+ P C
Sbjct: 3063 SCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTE--KGVWSQPYPVCEPL 3120
Query: 348 SCG 350
SCG
Sbjct: 3121 SCG 3123
Score = 35.4 bits (80), Expect = 0.24
Identities = 20/65 (30%), Positives = 31/65 (47%), Gaps = 3/65 (4%)
Query: 286 YLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 345
+L+ CG PP ++ + T T+ C GY L G +T+ CL + W+ C
Sbjct: 1959 HLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGK--WSRSDQQC 2016
Query: 346 MA-SC 349
+A SC
Sbjct: 2017 LAVSC 2021
Score = 33.1 bits (74), Expect = 1.2
Identities = 19/62 (30%), Positives = 31/62 (50%), Gaps = 5/62 (8%)
Query: 287 LLSCGFPPRPAHG-DVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPS 344
++ C PP + G + + LH G T + C G+ L+G T +C +GT W+ P
Sbjct: 2378 IVLCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGT---WSSPLPE 2434
Query: 345 CM 346
C+
Sbjct: 2435 CV 2436
Score = 33.1 bits (74), Expect = 1.2
Identities = 22/63 (34%), Positives = 27/63 (42%), Gaps = 5/63 (7%)
Query: 288 LSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCM 346
+SCG P + G T+ C SGY L+G +CL NGT W P C
Sbjct: 3414 ISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGT---WT-SPPICR 3469
Query: 347 ASC 349
A C
Sbjct: 3470 AVC 3472
Score = 30.8 bits (68), Expect = 6.0
Identities = 19/70 (27%), Positives = 26/70 (37%), Gaps = 2/70 (2%)
Query: 280 RIHYQAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTR--PS 337
R Q +SC PP H G A ++C GY L L+C + P
Sbjct: 2011 RSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPP 2070
Query: 338 WNGETPSCMA 347
+ P C+A
Sbjct: 2071 EGQDMPRCIA 2080
>gi|168693643 decay accelerating factor for complement isoform 2
precursor [Homo sapiens]
Length = 440
Score = 97.1 bits (240), Expect = 7e-20
Identities = 60/168 (35%), Positives = 85/168 (50%), Gaps = 8/168 (4%)
Query: 665 GTVLTYQCEPGY--ELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAG 722
GTV+ Y+C PGY E S LTC +L WS A C+K +C +PGEI NG G
Sbjct: 122 GTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKK-KSCPNPGEIRNGQIDVP-GG 179
Query: 723 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 782
G+ + + C GY L G+ C + +WSD +P+C Y C P +NG
Sbjct: 180 ILFGATISFSCNTGYKLFGSTSSFCLISGSSV-QWSDPLPECREIY--CPAPPQIDNGII 236
Query: 783 TLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 829
+ HY +S+ + C +GF +IGE +I C V +W+ PP C+
Sbjct: 237 QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECR 284
Score = 65.9 bits (159), Expect = 2e-10
Identities = 55/186 (29%), Positives = 79/186 (42%), Gaps = 18/186 (9%)
Query: 666 TVLTYQCEPGYELLGS--DILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTA---SD 720
TV+TY+CE + + D + C WS C + +C P + + +
Sbjct: 59 TVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNR--SCEVPTRLNSASLKQPYITQ 116
Query: 721 AGFPVGSHVQYRCLPGYSLEG--AAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 778
FPVG+ V+Y C PGY E + LTC KWS V C K + C NPG
Sbjct: 117 NYFPVGTVVEYECRPGYRREPSLSPKLTCLQ----NLKWSTAVEFC--KKKSCPNPGEIR 170
Query: 779 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKVTQTTDPS 837
NG Q G ++ F C G++L G + C + G QW+ P C+ P
Sbjct: 171 NG-QIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPP 229
Query: 838 RQLEGG 843
Q++ G
Sbjct: 230 -QIDNG 234
Score = 48.5 bits (114), Expect = 3e-05
Identities = 31/109 (28%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 660 GDLIRGTVLTYQCEPGYELLGSDILTC---QWDLSWSAAPPACQKIMTCADPGEIANGHR 716
G ++ G +++ C GY+L GS C + WS P C++I C P +I NG
Sbjct: 178 GGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIY-CPAPPQIDNGII 236
Query: 717 TASDAGFPVGSHVQYRCLPGYSLEGAAMLTC-YSRDTGTPKWSDRVPKC 764
+ V Y C G+++ G + C + D G +WS P+C
Sbjct: 237 QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEG--EWSGPPPEC 283
Score = 36.2 bits (82), Expect = 0.14
Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 10/63 (15%)
Query: 289 SCGFPPRPAHGDVSVTDLHPGG-----TATFHCDSGYQLQGEETLICL-NGTRPSWNGET 342
SC P +G + V PGG T +F C++GY+L G + CL +G+ W+
Sbjct: 162 SCPNPGEIRNGQIDV----PGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217
Query: 343 PSC 345
P C
Sbjct: 218 PEC 220
>gi|10835143 decay accelerating factor for complement isoform 1
preproprotein [Homo sapiens]
Length = 381
Score = 97.1 bits (240), Expect = 7e-20
Identities = 60/168 (35%), Positives = 85/168 (50%), Gaps = 8/168 (4%)
Query: 665 GTVLTYQCEPGY--ELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAG 722
GTV+ Y+C PGY E S LTC +L WS A C+K +C +PGEI NG G
Sbjct: 122 GTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKK-KSCPNPGEIRNGQIDVP-GG 179
Query: 723 FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQ 782
G+ + + C GY L G+ C + +WSD +P+C Y C P +NG
Sbjct: 180 ILFGATISFSCNTGYKLFGSTSSFCLISGSSV-QWSDPLPECREIY--CPAPPQIDNGII 236
Query: 783 TLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCK 829
+ HY +S+ + C +GF +IGE +I C V +W+ PP C+
Sbjct: 237 QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECR 284
Score = 65.9 bits (159), Expect = 2e-10
Identities = 55/186 (29%), Positives = 79/186 (42%), Gaps = 18/186 (9%)
Query: 666 TVLTYQCEPGYELLGS--DILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTA---SD 720
TV+TY+CE + + D + C WS C + +C P + + +
Sbjct: 59 TVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNR--SCEVPTRLNSASLKQPYITQ 116
Query: 721 AGFPVGSHVQYRCLPGYSLEG--AAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPE 778
FPVG+ V+Y C PGY E + LTC KWS V C K + C NPG
Sbjct: 117 NYFPVGTVVEYECRPGYRREPSLSPKLTCLQ----NLKWSTAVEFC--KKKSCPNPGEIR 170
Query: 779 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKVTQTTDPS 837
NG Q G ++ F C G++L G + C + G QW+ P C+ P
Sbjct: 171 NG-QIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPP 229
Query: 838 RQLEGG 843
Q++ G
Sbjct: 230 -QIDNG 234
Score = 48.5 bits (114), Expect = 3e-05
Identities = 31/109 (28%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 660 GDLIRGTVLTYQCEPGYELLGSDILTC---QWDLSWSAAPPACQKIMTCADPGEIANGHR 716
G ++ G +++ C GY+L GS C + WS P C++I C P +I NG
Sbjct: 178 GGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIY-CPAPPQIDNGII 236
Query: 717 TASDAGFPVGSHVQYRCLPGYSLEGAAMLTC-YSRDTGTPKWSDRVPKC 764
+ V Y C G+++ G + C + D G +WS P+C
Sbjct: 237 QGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEG--EWSGPPPEC 283
Score = 36.2 bits (82), Expect = 0.14
Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 10/63 (15%)
Query: 289 SCGFPPRPAHGDVSVTDLHPGG-----TATFHCDSGYQLQGEETLICL-NGTRPSWNGET 342
SC P +G + V PGG T +F C++GY+L G + CL +G+ W+
Sbjct: 162 SCPNPGEIRNGQIDV----PGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL 217
Query: 343 PSC 345
P C
Sbjct: 218 PEC 220
>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
sapiens]
Length = 569
Score = 93.6 bits (231), Expect = 8e-19
Identities = 94/372 (25%), Positives = 145/372 (38%), Gaps = 26/372 (6%)
Query: 489 FSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYS 548
+SC GY L G +A + W++ P C + G A + + +
Sbjct: 121 YSCPKGYRLI--GSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFH 178
Query: 549 PGQ----DCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRR 604
G C G ++ ++ + I + D + ++ G P + + P
Sbjct: 179 YGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENG 238
Query: 605 LL-SSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELP--------PPE--WG 653
+L S L + PG G H K N PELP PP+
Sbjct: 239 ILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHA 298
Query: 654 WRTASHGDLIR-GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCAD-PGEI 711
RT D G + Y CEPGY+L GS L C WS A P C+ + +C D G++
Sbjct: 299 ERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCE-VKSCDDFLGQL 357
Query: 712 ANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPC 771
NGH +G+ V + C G+ L+G++ C + W+ VP C K C
Sbjct: 358 PNGH-VLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES-LWNSSVPVCERK--SC 413
Query: 772 LNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCV-PGHPSQWTSQPPLCKV 830
P VP NG + G + + C G LIG + C+ G+ + W+ +PP+C+
Sbjct: 414 ETPPVPVNGMVHVIT-DIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQ 472
Query: 831 TQTTDPSRQLEG 842
+P L G
Sbjct: 473 IFCPNPPAILNG 484
Score = 73.9 bits (180), Expect = 6e-13
Identities = 59/229 (25%), Positives = 97/229 (42%), Gaps = 28/229 (12%)
Query: 665 GTVLTYQCEPG------YELLGSDILTCQWDLS----WSAAPPACQKIMTCADPGEIANG 714
G+V+TY C G +EL+G + C WS P C C P + NG
Sbjct: 180 GSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPN-VENG 238
Query: 715 HRTASDAG-FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLN 773
+ + F + V++RC PG+ ++G + + C + + KW +P C+ +P
Sbjct: 239 ILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALN----KWEPELPSCSRVCQP--P 292
Query: 774 PGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQT 833
P V K ++ G+ + + C G++L G + C P W+ P C+V
Sbjct: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTP--QGDWSPAAPRCEVKSC 350
Query: 834 TDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSH 882
D QL G+ +L PL L + G + + +G L G S S+
Sbjct: 351 DDFLGQLPNGH----VLFPLNLQL----GAKVDFVCDEGFQLKGSSASY 391
Score = 69.3 bits (168), Expect = 2e-11
Identities = 118/519 (22%), Positives = 182/519 (35%), Gaps = 111/519 (21%)
Query: 289 SCGFPPRPAHGDVSVT-DLHPGGTATFHCDSGYQLQGEETLICL-NGTRPSWNGETPSCM 346
SC PP P +G V D+ + C GY+L G + C+ +G W+ +TP C
Sbjct: 95 SCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVC- 153
Query: 347 ASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMV 406
RI+ P + T R + H+ V N +
Sbjct: 154 ------------DRIICGLPPTIANGDFTSI--------SREYFHYGSVVTYHCN----L 189
Query: 407 RSGGSPL-----SPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEE 461
S G + P IY + DD + G+ S PA ++
Sbjct: 190 GSRGKKVFELVGEPSIYCTSKDD--QVGIWSG------------PAPQCIIP-------- 227
Query: 462 DRCFAPFLAHGNVTTTDPE-YRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTE 520
++C P + +G + + + + + F C PG+ ++ P + ++C + W
Sbjct: 228 NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGP---SHVKCQALNK--WEPEL 282
Query: 521 PACKAMCGGELSEPAGVVLSPDWPQ----SYSPGQDCVWGVHVQEEKRILLQVEILNVRE 576
P+C +C +P VL + Q ++SPGQ+ + + R + +
Sbjct: 283 PSCSRVC-----QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHC--TPQ 335
Query: 577 GDMLTL-----------FDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNP 625
GD F G P+ VL L L G + F G
Sbjct: 336 GDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLN--------LQLGAKV--DFVCDEGFQLK 385
Query: 626 GLGQGF-VLHFKEVPRNDTCP-------ELPPPEWGWRTASHGDLIRGTVLTYQCEPGYE 677
G + VL E N + P E PP D+ G+ + Y C G+
Sbjct: 386 GSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHR 445
Query: 678 LLGSDILTCQWD---LSWSAAPPACQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRC 733
L+G C WS PP CQ+I C +P I NG T + G P G V Y C
Sbjct: 446 LIGHSSAECILSGNTAHWSMKPPICQQIF-CPNPPAILNGRHTGTPLGDIPYGKEVSYTC 504
Query: 734 LP------GYSLEGAAMLTCYSRDTGTPKWSDRVPKCAL 766
P ++L G + + S G WS P+C L
Sbjct: 505 DPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCEL 543
Score = 66.6 bits (161), Expect = 1e-10
Identities = 56/203 (27%), Positives = 79/203 (38%), Gaps = 15/203 (7%)
Query: 636 KEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWD---LSW 692
K+ + +C P P G R + Y C GY L+GS TC + W
Sbjct: 88 KDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQI-KYSCPKGYRLIGSSSATCIISGNTVIW 146
Query: 693 SAAPPACQKIMTCADPGEIANGHRTA-SDAGFPVGSHVQYRCLPG------YSLEGAAML 745
P C +I+ C P IANG T+ S F GS V Y C G + L G +
Sbjct: 147 DNKTPVCDRII-CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSI 205
Query: 746 TCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFEL 805
C S+D WS P+C + C P V + + + E + F C GF +
Sbjct: 206 YCTSKDDQVGIWSGPAPQCIIP-NKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGM 264
Query: 806 IGEVTITCVPGHPSQWTSQPPLC 828
G + C ++W + P C
Sbjct: 265 KGPSHVKCQA--LNKWEPELPSC 285
Score = 65.1 bits (157), Expect = 3e-10
Identities = 48/181 (26%), Positives = 78/181 (43%), Gaps = 15/181 (8%)
Query: 665 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANG-HRTASDAGF 723
GT L Y+C PGY I+ C + W++A C++ +C +P + NG D F
Sbjct: 58 GTYLNYECRPGYSGRPFSII-CLKNSVWTSAKDKCKR-KSCRNPPDPVNGMAHVIKDIQF 115
Query: 724 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT 783
S ++Y C GY L G++ TC T W ++ P C + L P + + +
Sbjct: 116 --RSQIKYSCPKGYRLIGSSSATCII-SGNTVIWDNKTPVCD-RIICGLPPTIANGDFTS 171
Query: 784 LYKHHYQAGESLRFFCYEG------FELIGEVTITCV--PGHPSQWTSQPPLCKVTQTTD 835
+ + ++ G + + C G FEL+GE +I C W+ P C +
Sbjct: 172 ISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCT 231
Query: 836 P 836
P
Sbjct: 232 P 232
Score = 58.9 bits (141), Expect = 2e-08
Identities = 34/110 (30%), Positives = 55/110 (50%), Gaps = 9/110 (8%)
Query: 720 DAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPEN 779
D FP+G+++ Y C PGYS +++ C W+ KC K + C NP P N
Sbjct: 52 DFEFPIGTYLNYECRPGYSGRPFSII-CLKNSV----WTSAKDKC--KRKSCRNPPDPVN 104
Query: 780 GYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLC 828
G + K Q +++ C +G+ LIG + TC + G+ W ++ P+C
Sbjct: 105 GMAHVIK-DIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVC 153
>gi|157419154 selectin P precursor [Homo sapiens]
Length = 830
Score = 90.1 bits (222), Expect = 8e-18
Identities = 138/585 (23%), Positives = 212/585 (36%), Gaps = 109/585 (18%)
Query: 286 YLLSCGFPPRPAHGDVSVTDLHPGGT------ATFHCDSGYQLQGEETLICLNGTRPSWN 339
Y+ CG P H V + HP G +FHC GYQ+ G L CL W
Sbjct: 196 YVRECGELELPQH--VLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECL--ASGIWT 251
Query: 340 GETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDE 399
+ P C+A A + PE G N+TC LH + +
Sbjct: 252 NKPPQCLA--------AQCPPLKIPERG-----NMTC-------------LHSAKAFQHQ 285
Query: 400 DNDRLMVRSGGSPLSPVIYDSDMDDV--PERGLISDAQSLYVELLSETPANPLLLSLRFE 457
+ G + + P + V + Q ++E SE +
Sbjct: 286 SSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMD--------- 336
Query: 458 AFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWN 517
C P A + G+ F C PGY + + + C+D HW+
Sbjct: 337 ------CVHPLTA----------FAYGSSCKFECQPGYRVRGL---DMLRCID--SGHWS 375
Query: 518 DTEPACKAMCGGELSEPA--GVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR 575
P C+A+ L P + SP +++ +C + E +L +I+
Sbjct: 376 APLPTCEAISCEPLESPVHGSMDCSPSL-RAFQYDTNCSFRC---AEGFMLRGADIVRC- 430
Query: 576 EGDMLTLFDGDGPSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPG-PPNPGL---GQG 630
D L + P + L P P R+ S P ++Q+ N GL G
Sbjct: 431 --DNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGAS 488
Query: 631 FVL-----HFKEVP---RNDTCPELPPPEWGWRTASH--GDLIRGTVLTYQCEPGYELLG 680
+ ++ VP + C L P+ G T G + + C+ GY L G
Sbjct: 489 VLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSG 548
Query: 681 SDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD--AGFPVGSHVQYRCLPGYS 738
+ L C W+ +PP C+ I C + G SD F VGS + C G+
Sbjct: 549 PERLDCTRSGRWTDSPPMCEAI-KCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFK 607
Query: 739 LEGAAMLTCYSRDTGTPKWSDRVPKC----ALKYEPCLNPGVPENGYQTLY-KHH---YQ 790
LEG + C T + +WS P C +L P + G T+Y +HH +
Sbjct: 608 LEGPNNVEC----TTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFG 663
Query: 791 AGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTD 835
+ F C GF LIG+ T++C P QWT+ P C+ + ++
Sbjct: 664 FNTTCYFGCNAGFTLIGDSTLSCRPS--GQWTAVTPACRAVKCSE 706
Score = 66.2 bits (160), Expect = 1e-10
Identities = 60/219 (27%), Positives = 88/219 (40%), Gaps = 22/219 (10%)
Query: 644 CPELPPPEWGWRTASHG--DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQK 701
C L P G H G+ ++C+PGY + G D+L C WSA P C+
Sbjct: 324 CQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEA 383
Query: 702 IMTCADPGEIANGHRTASDA--GFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSD 759
I +C +G S + F ++ +RC G+ L GA ++ C +W+
Sbjct: 384 I-SCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRC----DNLGQWTA 438
Query: 760 RVPKC-ALKYEPCLNPGVPENGYQTLYKHHYQA---GESLRFFCYEGFELIGEVTITCVP 815
P C AL+ C + VP N + H + A F C EG L+G + C+
Sbjct: 439 PAPVCQALQ---CQDLPVP-NEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLA 494
Query: 816 GHPSQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLPLG 854
W S PP C+ T L N + + PLG
Sbjct: 495 --TGNWNSVPPECQAIPCTP---LLSPQNGTMTCVQPLG 528
Score = 60.8 bits (146), Expect = 5e-09
Identities = 59/224 (26%), Positives = 88/224 (39%), Gaps = 20/224 (8%)
Query: 644 CPELPPPEWGWRTAS--HGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQK 701
CPEL PE G S G+ G+ + C+ G++L G + + C WSA PP C+
Sbjct: 572 CPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKG 631
Query: 702 IMTCADPGEIANGHRTASD---------AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDT 752
I + PG T F + + C G++L G + L+C R +
Sbjct: 632 IASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSC--RPS 689
Query: 753 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTIT 812
G +W+ P C L+ P + ++ G F C EG L G
Sbjct: 690 G--QWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTA 747
Query: 813 CVP-GHPSQWTSQPPLCKV-TQTTDPSRQLEGGNLALAILLPLG 854
C GH W++ P C+ T + GG +A I L +G
Sbjct: 748 CQENGH---WSTTVPTCQAGPLTIQEALTYFGGAVASTIGLIMG 788
Score = 59.7 bits (143), Expect = 1e-08
Identities = 41/153 (26%), Positives = 60/153 (39%), Gaps = 18/153 (11%)
Query: 697 PACQKIMTCADPGEIANGHRTASDAGFPVG-----SHVQYRCLPGYSLEGAAMLTCYSRD 751
P C+ + C GE+ + P+G S + C GY + G + L C +
Sbjct: 192 PECEYVREC---GELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASG 248
Query: 752 TGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHH--YQAGESLRFFCYEGFELIGEV 809
W+++ P+C P L +PE G T +Q S F C EGF L+G
Sbjct: 249 I----WTNKPPQCLAAQCPPLK--IPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPE 302
Query: 810 TITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEG 842
+ C WT+ P+CK Q EG
Sbjct: 303 VVQCTAS--GVWTAPAPVCKAVQCQHLEAPSEG 333
Score = 34.3 bits (77), Expect = 0.54
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 11/55 (20%)
Query: 307 HPGG-----TATFHCDSGYQLQGEETLICLNGTRPS--WNGETPSCMASCGGTIH 354
HPG T F C++G+ L G+ TL C RPS W TP+C A +H
Sbjct: 658 HPGTFGFNTTCYFGCNAGFTLIGDSTLSC----RPSGQWTAVTPACRAVKCSELH 708
>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
isoform 2 [Homo sapiens]
Length = 1033
Score = 84.3 bits (207), Expect = 5e-16
Identities = 65/247 (26%), Positives = 97/247 (39%), Gaps = 14/247 (5%)
Query: 644 CPELPPPEWGWR-TASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQK- 701
CP P + G++ +H ++ C PG+ + GS ++ C D +W P C K
Sbjct: 788 CPN-PEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKK 846
Query: 702 -IMTCADPGEIANGHRTASD-AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSD 759
+ C P + NG+ T + A F G + Y C GY L G A+L C T WS
Sbjct: 847 AFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGT----WSQ 902
Query: 760 RVPKCALKYEPCLNPGVPENGYQTLY-KHHYQAGESLRFFCYEGFELIGEVTITCVPGHP 818
P C K C +P + + L + YQ G + C +G+ L G C H
Sbjct: 903 PAPHC--KEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDH- 959
Query: 819 SQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGF 878
QW +C+ + G + L L+ + L ++ YYT K F
Sbjct: 960 -QWNPPLAVCRSRSLAPVLCGIAAGLILLTFLIVITLYVISKHRARNYYTDTSQKEAFHL 1018
Query: 879 SGSHSYS 885
YS
Sbjct: 1019 EAREVYS 1025
Score = 78.6 bits (192), Expect = 3e-14
Identities = 58/216 (26%), Positives = 97/216 (44%), Gaps = 20/216 (9%)
Query: 635 FKEVPRNDTCPELPPPEW--GWRTASHGD-LIRGTVLTYQCEPGYELLGSDILTCQWDL- 690
FK++P PPP G T + + G ++Y+C+ G+ LLG L C+ D
Sbjct: 708 FKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSK 767
Query: 691 ---SWSAAPPACQK---IMTCADPGEIANGHR-TASDAGFPVGSHVQYRCLPGYSLEGAA 743
SWS P C + + C +P E+ +G++ + + + V C PG+ + G+
Sbjct: 768 GHGSWSGPSPQCLRSPPVTRCPNP-EVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 826
Query: 744 MLTCYSRDTGTPKWSDRVPKCALK-YEPCLNPGVPENGYQTLYK-HHYQAGESLRFFCYE 801
++ C++ +T W VP C K + C P NG T + G S+ + C +
Sbjct: 827 VIRCHTDNT----WVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQ 882
Query: 802 GFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPS 837
G+ L+GE + C H W+ P CK + P+
Sbjct: 883 GYLLVGEALLLCT--HEGTWSQPAPHCKEVNCSSPA 916
Score = 76.3 bits (186), Expect = 1e-13
Identities = 56/168 (33%), Positives = 74/168 (44%), Gaps = 14/168 (8%)
Query: 672 CEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDA-GFPVGSHVQ 730
C GY+L GS CQ + W C++I TC P I NG T S FP G+ V
Sbjct: 495 CGEGYKLSGSVYQECQGTIPWFMEIRLCKEI-TCPPPPVIYNGAHTGSSLEDFPYGTTVT 553
Query: 731 YRCLPG------YSLEGAAMLTCYSRDTGTPKWSDRVPKCALKY--EPCLNPGVPENGYQ 782
Y C PG +SL G + + C S D WS P C L C + + NGY+
Sbjct: 554 YTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHI-ANGYK 612
Query: 783 TLYKH-HYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 829
K Y +++ F CY GF L G I C + W + P+C+
Sbjct: 613 ISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKA--DNTWDPEIPVCE 658
Score = 75.9 bits (185), Expect = 2e-13
Identities = 139/606 (22%), Positives = 205/606 (33%), Gaps = 141/606 (23%)
Query: 306 LHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCMA-------------SCGG 351
L G TA F CD GY+LQG + C + G +W + P C G
Sbjct: 232 LRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGN 290
Query: 352 TIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFER-VSLDEDNDRLMVRSGG 410
++ N + G IV+ TC + EG L E + D+ + SG
Sbjct: 291 SLANVSYGSIVT----------YTCD--PDPEEGVNFILIGESTLRCTVDSQKTGTWSGP 338
Query: 411 SP---LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 467
+P LS + ++S + Y ++T + + ++ RC A
Sbjct: 339 APRCELSTSAVQCPHPQILRGRMVSGQKDRYT--YNDTVIFACMFGFTLKGSKQIRCNAQ 396
Query: 468 FLAHGNVTTTDPE-------------------YRPGALATFSCLPGYALEPPGPPNAIEC 508
+ + E + PG +SC PGY L +I+C
Sbjct: 397 GTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGE---ESIQC 453
Query: 509 VDPTEPHWNDTEPACK-AMCGGE----LSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEK 563
+E W P CK A C L++P + PD S G V+ + +
Sbjct: 454 T--SEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQG 511
Query: 564 RILLQVEILNVRE------------------------GDMLTLFDGDGPSARVLAQLRGP 599
I +EI +E G +T GP V L G
Sbjct: 512 TIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGE 571
Query: 600 QPRRRLLSSGPDLTLQFQAPPGP--------PNPGLGQGFVLHFKEVPR--NDTCPELPP 649
R + T AP + + G+ + KE P NDT
Sbjct: 572 STIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDT------ 625
Query: 650 PEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPG 709
+T++C G+ L GS + C+ D +W P C+K TC
Sbjct: 626 ------------------VTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEK-ETCQ--- 663
Query: 710 EIANGHRTASDAGFPVGSHVQY---RCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCAL 766
H S P GS V+ C GY L G A C + G W ++P C
Sbjct: 664 -----HVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGI--WFKKIPLC-- 714
Query: 767 KYEPCLNPGVPENGYQT-LYKHHYQAGESLRFFCYEGFELIGEVTITC---VPGHPSQWT 822
K C P V NG T + ++ G + + C +GF L+GE + C GH S W+
Sbjct: 715 KVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGS-WS 773
Query: 823 SQPPLC 828
P C
Sbjct: 774 GPSPQC 779
Score = 74.3 bits (181), Expect = 5e-13
Identities = 60/240 (25%), Positives = 94/240 (39%), Gaps = 22/240 (9%)
Query: 615 QFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTA-SHGDLIRGTVLTYQCE 673
+ Q PP GQG V CP PP G S ++ G+++TY C+
Sbjct: 247 RLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCD 306
Query: 674 PGYE------LLGSDILTCQWDL----SWSAAPPACQ---KIMTCADPGEIANGHRTASD 720
P E L+G L C D +WS P C+ + C P + +
Sbjct: 307 PDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQK 366
Query: 721 AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENG 780
+ V + C+ G++L+G+ + C ++ T W P C + E P +
Sbjct: 367 DRYTYNDTVIFACMFGFTLKGSKQIRCNAQGT----WEPSAPVC--EKECQAPPNILNGQ 420
Query: 781 YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQL 840
+ + + G S+++ C G+ L+GE +I C WT P CKV RQL
Sbjct: 421 KEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCT--SEGVWTPPVPQCKVAACEATGRQL 478
Score = 69.7 bits (169), Expect = 1e-11
Identities = 61/227 (26%), Positives = 96/227 (42%), Gaps = 33/227 (14%)
Query: 629 QGFVLHFKEVP--RNDTCPELPPPEWGWRTASH-GDLIRGTVLTYQCEPG------YELL 679
QG + F E+ + TCP P G T S D GT +TY C PG + L+
Sbjct: 510 QGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLI 569
Query: 680 GSDILTC----QWDLSWSAAPPACQKIMTCADPG--EIANGHR-TASDAGFPVGSHVQYR 732
G + C Q +WS P C+ + IANG++ + +A + V ++
Sbjct: 570 GESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFK 629
Query: 733 CLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAG 792
C G++L+G++ + C + +T W +P C + E C ++ Q+L AG
Sbjct: 630 CYSGFTLKGSSQIRCKADNT----WDPEIPVC--EKETC------QHVRQSL--QELPAG 675
Query: 793 ---ESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDP 836
E + C +G++L G C W + PLCKV P
Sbjct: 676 SRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPP 722
Score = 69.3 bits (168), Expect = 2e-11
Identities = 51/193 (26%), Positives = 84/193 (43%), Gaps = 18/193 (9%)
Query: 648 PPPEWGWRTASHGDLIR-GTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPACQ-- 700
PPP R + + I GTV+ Y C + L+G L C + D +W P C+
Sbjct: 26 PPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYF 85
Query: 701 -KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSD 759
K +C +P + G++ + G V + C +S+ G + C + + P
Sbjct: 86 NKYSSCPEP-IVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGP---T 141
Query: 760 RVPKCALKYEPCLNPGVP--ENGYQTLYK-HHYQAGESLRFFCYEGFELIGEVTITCVPG 816
R+P C + P P +P NG+ T G S+ + C G+ L+GE I C+
Sbjct: 142 RLPTCVSVF-PLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSS 200
Query: 817 HPSQWTSQPPLCK 829
+W++ PP C+
Sbjct: 201 --GKWSAVPPTCE 211
Score = 68.2 bits (165), Expect = 3e-11
Identities = 58/208 (27%), Positives = 87/208 (41%), Gaps = 14/208 (6%)
Query: 643 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAP-PACQK 701
+CPE P G++ G +T+ C+ + + G+ + CQ + W P C
Sbjct: 90 SCPE-PIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVS 148
Query: 702 I--MTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWS 758
+ + C I NGH T+ + G G V Y C GY L G ++ C S + KWS
Sbjct: 149 VFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLS----SGKWS 204
Query: 759 DRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCV-PGH 817
P C + C + G NG + + G + FFC EG+ L G + CV G
Sbjct: 205 AVPPTC--EEARCKSLGRFPNG-KVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQ 261
Query: 818 PSQWTSQPPLCKVTQTTDPSRQLEGGNL 845
WT P+C+ P L G ++
Sbjct: 262 GVAWTKM-PVCEEIFCPSPPPILNGRHI 288
Score = 68.2 bits (165), Expect = 3e-11
Identities = 60/200 (30%), Positives = 84/200 (42%), Gaps = 20/200 (10%)
Query: 644 CPELPPPEWGWRTASH-GDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 702
CP LP G T+ + G + G +TY CE GY L+G I+ C WSA PP C++
Sbjct: 154 CPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEE- 212
Query: 703 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 762
C G NG + VG + C GY L+G C G W+ ++P
Sbjct: 213 ARCKSLGRFPNG-KVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGV-AWT-KMP 269
Query: 763 KCALKYEPCLNPGVPENGY---QTLYKHHYQAGESLRFFC----YEG--FELIGEVTITC 813
C + C +P NG +L Y G + + C EG F LIGE T+ C
Sbjct: 270 VCEEIF--CPSPPPILNGRHIGNSLANVSY--GSIVTYTCDPDPEEGVNFILIGESTLRC 325
Query: 814 V--PGHPSQWTSQPPLCKVT 831
W+ P C+++
Sbjct: 326 TVDSQKTGTWSGPAPRCELS 345
Score = 67.0 bits (162), Expect = 8e-11
Identities = 65/201 (32%), Positives = 86/201 (42%), Gaps = 27/201 (13%)
Query: 664 RGTVLTYQCEPGYELLGSDILTCQWDLS--WSAAPPACQKIMTCADPGEIANGHRTASDA 721
R ++ C+ GY+L G CQ + W P C K++ C P I NG T A
Sbjct: 677 RVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLC-KVIHCHPPPVIVNGKHTGMMA 735
Query: 722 -GFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEP---CLNPGVP 777
F G+ V Y C G+ L G L C S G WS P+C L+ P C NP V
Sbjct: 736 ENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQC-LRSPPVTRCPNPEV- 793
Query: 778 ENGYQTLYKHH--YQAGESLRFFCYEGFELIGEVTITC------VPGHPS----QWTSQP 825
++GY+ L K H Y + + C GF + G I C VPG P+ + P
Sbjct: 794 KHGYK-LNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCP 852
Query: 826 PLCKVTQTTDPSRQLEGGNLA 846
P K P+ GGN+A
Sbjct: 853 PPPKT-----PNGNHTGGNIA 868
Score = 63.5 bits (153), Expect = 8e-10
Identities = 49/162 (30%), Positives = 67/162 (41%), Gaps = 17/162 (10%)
Query: 670 YQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD-AGFPVGSH 728
+ C G+ L GS + C +W + P C+K C P I NG + F G+
Sbjct: 377 FACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK--ECQAPPNILNGQKEDRHMVRFDPGTS 434
Query: 729 VQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHH 788
++Y C PGY L G + C S W+ VP+C K C G Q L K
Sbjct: 435 IKYSCNPGYVLVGEESIQCTSEGV----WTPPVPQC--KVAAC-----EATGRQLLTKPQ 483
Query: 789 YQ-AGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 829
+Q + C EG++L G V C P W + LCK
Sbjct: 484 HQFVRPDVNSSCGEGYKLSGSVYQECQGTIP--WFMEIRLCK 523
Score = 63.2 bits (152), Expect = 1e-09
Identities = 53/176 (30%), Positives = 70/176 (39%), Gaps = 20/176 (11%)
Query: 665 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 724
GT + Y C PGY L+G + + C + W+ P C K+ C G T F
Sbjct: 432 GTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC-KVAACEATGRQL---LTKPQHQF- 486
Query: 725 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT- 783
V V C GY L G+ C GT W + C K C P V NG T
Sbjct: 487 VRPDVNSSCGEGYKLSGSVYQEC----QGTIPWFMEIRLC--KEITCPPPPVIYNGAHTG 540
Query: 784 LYKHHYQAGESLRFFCYEG------FELIGEVTITCVPGHPSQ--WTSQPPLCKVT 831
+ G ++ + C G F LIGE TI C + W+ PLCK++
Sbjct: 541 SSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLS 596
Score = 60.5 bits (145), Expect = 7e-09
Identities = 34/113 (30%), Positives = 50/113 (44%), Gaps = 3/113 (2%)
Query: 703 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 762
++C P I NG + VG+ ++Y C + L G L C ++D W P
Sbjct: 21 ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
Query: 763 KCAL--KYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC 813
KC KY C P VP GY+ Y+ G+S+ F C F + G ++ C
Sbjct: 81 KCEYFNKYSSCPEPIVP-GGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWC 132
Score = 39.3 bits (90), Expect = 0.017
Identities = 19/67 (28%), Positives = 35/67 (52%), Gaps = 2/67 (2%)
Query: 298 HGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNAT 357
H +V + PG + T+ C+SGY L GE+ + CL+ + W+ P+C + ++
Sbjct: 165 HTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK--WSAVPPTCEEARCKSLGRFP 222
Query: 358 LGRIVSP 364
G++ P
Sbjct: 223 NGKVKEP 229
Score = 37.4 bits (85), Expect = 0.064
Identities = 19/67 (28%), Positives = 33/67 (49%), Gaps = 5/67 (7%)
Query: 287 LLSCGFPP---RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTR--PSWNGE 341
++ C PP H + + G ++ CD G+ L GE+ L C + ++ SW+G
Sbjct: 716 VIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGP 775
Query: 342 TPSCMAS 348
+P C+ S
Sbjct: 776 SPQCLRS 782
Score = 37.0 bits (84), Expect = 0.084
Identities = 18/61 (29%), Positives = 30/61 (49%), Gaps = 5/61 (8%)
Query: 288 LSCGFPPRPAHGDVS---VTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS 344
+ C PP+ +G+ + + PG + + CD GY L GE L+C + +W+ P
Sbjct: 849 IGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTH--EGTWSQPAPH 906
Query: 345 C 345
C
Sbjct: 907 C 907
Score = 36.6 bits (83), Expect = 0.11
Identities = 18/62 (29%), Positives = 32/62 (51%), Gaps = 4/62 (6%)
Query: 288 LSCGFPPRPAHGDVSV--TDLHPGGTATFHCDSGYQLQGEETLICLNGTR--PSWNGETP 343
+SCG PP +G +S T + G + C ++L GE++L+C+ + +W+ P
Sbjct: 21 ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
Query: 344 SC 345
C
Sbjct: 81 KC 82
Score = 35.4 bits (80), Expect = 0.24
Identities = 21/67 (31%), Positives = 31/67 (46%), Gaps = 6/67 (8%)
Query: 290 CGFPPRPAHG---DVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC- 345
C PP +G D + PG + + C+ GY L GEE++ C + W P C
Sbjct: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCT--SEGVWTPPVPQCK 467
Query: 346 MASCGGT 352
+A+C T
Sbjct: 468 VAACEAT 474
>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
isoform 1 [Homo sapiens]
Length = 1092
Score = 84.3 bits (207), Expect = 5e-16
Identities = 65/247 (26%), Positives = 97/247 (39%), Gaps = 14/247 (5%)
Query: 644 CPELPPPEWGWR-TASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQK- 701
CP P + G++ +H ++ C PG+ + GS ++ C D +W P C K
Sbjct: 847 CPN-PEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKK 905
Query: 702 -IMTCADPGEIANGHRTASD-AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSD 759
+ C P + NG+ T + A F G + Y C GY L G A+L C T WS
Sbjct: 906 AFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGT----WSQ 961
Query: 760 RVPKCALKYEPCLNPGVPENGYQTLY-KHHYQAGESLRFFCYEGFELIGEVTITCVPGHP 818
P C K C +P + + L + YQ G + C +G+ L G C H
Sbjct: 962 PAPHC--KEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDH- 1018
Query: 819 SQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGF 878
QW +C+ + G + L L+ + L ++ YYT K F
Sbjct: 1019 -QWNPPLAVCRSRSLAPVLCGIAAGLILLTFLIVITLYVISKHRARNYYTDTSQKEAFHL 1077
Query: 879 SGSHSYS 885
YS
Sbjct: 1078 EAREVYS 1084
Score = 79.7 bits (195), Expect = 1e-14
Identities = 147/642 (22%), Positives = 218/642 (33%), Gaps = 154/642 (23%)
Query: 306 LHPGGTATFHCDSGYQLQGEETLIC-LNGTRPSWNGETPSCMA-------------SCGG 351
L G TA F CD GY+LQG + C + G +W + P C G
Sbjct: 232 LRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMPVCEEIFCPSPPPILNGRHIGN 290
Query: 352 TIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFER-VSLDEDNDRLMVRSGG 410
++ N + G IV+ TC + EG L E + D+ + SG
Sbjct: 291 SLANVSYGSIVT----------YTCD--PDPEEGVNFILIGESTLRCTVDSQKTGTWSGP 338
Query: 411 SP---LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAP 467
+P LS + ++S + Y ++T + + ++ RC A
Sbjct: 339 APRCELSTSAVQCPHPQILRGRMVSGQKDRYT--YNDTVIFACMFGFTLKGSKQIRCNAQ 396
Query: 468 FLAHGNVTTTDPE-------------------YRPGALATFSCLPGYALEPPGPPNAIEC 508
+ + E + PG +SC PGY L +I+C
Sbjct: 397 GTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGE---ESIQC 453
Query: 509 VDPTEPHWNDTEPACK-AMCGGE----LSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEK 563
+E W P CK A C L++P + PD S G V+ + +
Sbjct: 454 T--SEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQG 511
Query: 564 RILLQVEILNVRE------------------------GDMLTLFDGDGPSARVLAQLRGP 599
I +EI +E G +T GP V L G
Sbjct: 512 TIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGE 571
Query: 600 QPRRRLLSSGPDLTLQFQAPPGP--------PNPGLGQGFVLHFKEVPR--NDTC----- 644
R + T AP + + G+ + KE P NDT
Sbjct: 572 STIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCY 631
Query: 645 --------------------PELPPPEWGWRTAS---HGD--------LIRGTVLTYQCE 673
PE+P E G ++ HG + G + Y C+
Sbjct: 632 SGFTLKGSSQIRCKADNTWDPEIPVCEKGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCD 691
Query: 674 PGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQY-- 731
PGY L+G+ + C +WS + P C++ TC H S P GS V+
Sbjct: 692 PGYLLVGNKSIHCMPSGNWSPSAPRCEE--TCQ--------HVRQSLQELPAGSRVELVN 741
Query: 732 -RCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT-LYKHHY 789
C GY L G A C + G W ++P C K C P V NG T + ++
Sbjct: 742 TSCQDGYQLTGHAYQMCQDAENGI--WFKKIPLC--KVIHCHPPPVIVNGKHTGMMAENF 797
Query: 790 QAGESLRFFCYEGFELIGEVTITC---VPGHPSQWTSQPPLC 828
G + + C +GF L+GE + C GH S W+ P C
Sbjct: 798 LYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGS-WSGPSPQC 838
Score = 77.4 bits (189), Expect = 6e-14
Identities = 68/224 (30%), Positives = 91/224 (40%), Gaps = 28/224 (12%)
Query: 672 CEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDA-GFPVGSHVQ 730
C GY+L GS CQ + W C++I TC P I NG T S FP G+ V
Sbjct: 495 CGEGYKLSGSVYQECQGTIPWFMEIRLCKEI-TCPPPPVIYNGAHTGSSLEDFPYGTTVT 553
Query: 731 YRCLPG------YSLEGAAMLTCYSRDTGTPKWSDRVPKCALKY--EPCLNPGVPENGYQ 782
Y C PG +SL G + + C S D WS P C L C + + NGY+
Sbjct: 554 YTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHI-ANGYK 612
Query: 783 TLYKH-HYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPS---R 838
K Y +++ F CY GF L G I C + W + P+C+ + P
Sbjct: 613 ISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKA--DNTWDPEIPVCEKGCQSPPGLHHG 670
Query: 839 QLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSH 882
+ GGN + SG+ + YT G L G H
Sbjct: 671 RHTGGNTVFFV-----------SGMTVDYTCDPGYLLVGNKSIH 703
Score = 74.3 bits (181), Expect = 5e-13
Identities = 60/240 (25%), Positives = 94/240 (39%), Gaps = 22/240 (9%)
Query: 615 QFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTA-SHGDLIRGTVLTYQCE 673
+ Q PP GQG V CP PP G S ++ G+++TY C+
Sbjct: 247 RLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCD 306
Query: 674 PGYE------LLGSDILTCQWDL----SWSAAPPACQ---KIMTCADPGEIANGHRTASD 720
P E L+G L C D +WS P C+ + C P + +
Sbjct: 307 PDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQK 366
Query: 721 AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENG 780
+ V + C+ G++L+G+ + C ++ T W P C + E P +
Sbjct: 367 DRYTYNDTVIFACMFGFTLKGSKQIRCNAQGT----WEPSAPVC--EKECQAPPNILNGQ 420
Query: 781 YQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQL 840
+ + + G S+++ C G+ L+GE +I C WT P CKV RQL
Sbjct: 421 KEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCT--SEGVWTPPVPQCKVAACEATGRQL 478
Score = 73.9 bits (180), Expect = 6e-13
Identities = 59/221 (26%), Positives = 100/221 (45%), Gaps = 28/221 (12%)
Query: 629 QGFVLHFKEVP--RNDTCPELPPPEWGWRTASH-GDLIRGTVLTYQCEPG------YELL 679
QG + F E+ + TCP P G T S D GT +TY C PG + L+
Sbjct: 510 QGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLI 569
Query: 680 GSDILTC----QWDLSWSAAPPACQKIMTCADPG--EIANGHR-TASDAGFPVGSHVQYR 732
G + C Q +WS P C+ + IANG++ + +A + V ++
Sbjct: 570 GESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFK 629
Query: 733 CLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKC--ALKYEPCLNPGVPENGYQTLYKHHYQ 790
C G++L+G++ + C + +T W +P C + P L+ G G T++ +
Sbjct: 630 CYSGFTLKGSSQIRCKADNT----WDPEIPVCEKGCQSPPGLHHG-RHTGGNTVF---FV 681
Query: 791 AGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVT 831
+G ++ + C G+ L+G +I C+P W+ P C+ T
Sbjct: 682 SGMTVDYTCDPGYLLVGNKSIHCMPS--GNWSPSAPRCEET 720
Score = 69.3 bits (168), Expect = 2e-11
Identities = 51/193 (26%), Positives = 84/193 (43%), Gaps = 18/193 (9%)
Query: 648 PPPEWGWRTASHGDLIR-GTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPACQ-- 700
PPP R + + I GTV+ Y C + L+G L C + D +W P C+
Sbjct: 26 PPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYF 85
Query: 701 -KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSD 759
K +C +P + G++ + G V + C +S+ G + C + + P
Sbjct: 86 NKYSSCPEP-IVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGP---T 141
Query: 760 RVPKCALKYEPCLNPGVP--ENGYQTLYK-HHYQAGESLRFFCYEGFELIGEVTITCVPG 816
R+P C + P P +P NG+ T G S+ + C G+ L+GE I C+
Sbjct: 142 RLPTCVSVF-PLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSS 200
Query: 817 HPSQWTSQPPLCK 829
+W++ PP C+
Sbjct: 201 --GKWSAVPPTCE 211
Score = 68.2 bits (165), Expect = 3e-11
Identities = 58/208 (27%), Positives = 87/208 (41%), Gaps = 14/208 (6%)
Query: 643 TCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAP-PACQK 701
+CPE P G++ G +T+ C+ + + G+ + CQ + W P C
Sbjct: 90 SCPE-PIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVS 148
Query: 702 I--MTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWS 758
+ + C I NGH T+ + G G V Y C GY L G ++ C S + KWS
Sbjct: 149 VFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLS----SGKWS 204
Query: 759 DRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCV-PGH 817
P C + C + G NG + + G + FFC EG+ L G + CV G
Sbjct: 205 AVPPTC--EEARCKSLGRFPNG-KVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQ 261
Query: 818 PSQWTSQPPLCKVTQTTDPSRQLEGGNL 845
WT P+C+ P L G ++
Sbjct: 262 GVAWTKM-PVCEEIFCPSPPPILNGRHI 288
Score = 68.2 bits (165), Expect = 3e-11
Identities = 60/200 (30%), Positives = 84/200 (42%), Gaps = 20/200 (10%)
Query: 644 CPELPPPEWGWRTASH-GDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKI 702
CP LP G T+ + G + G +TY CE GY L+G I+ C WSA PP C++
Sbjct: 154 CPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEE- 212
Query: 703 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 762
C G NG + VG + C GY L+G C G W+ ++P
Sbjct: 213 ARCKSLGRFPNG-KVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGV-AWT-KMP 269
Query: 763 KCALKYEPCLNPGVPENGY---QTLYKHHYQAGESLRFFC----YEG--FELIGEVTITC 813
C + C +P NG +L Y G + + C EG F LIGE T+ C
Sbjct: 270 VCEEIF--CPSPPPILNGRHIGNSLANVSY--GSIVTYTCDPDPEEGVNFILIGESTLRC 325
Query: 814 V--PGHPSQWTSQPPLCKVT 831
W+ P C+++
Sbjct: 326 TVDSQKTGTWSGPAPRCELS 345
Score = 67.0 bits (162), Expect = 8e-11
Identities = 65/201 (32%), Positives = 86/201 (42%), Gaps = 27/201 (13%)
Query: 664 RGTVLTYQCEPGYELLGSDILTCQWDLS--WSAAPPACQKIMTCADPGEIANGHRTASDA 721
R ++ C+ GY+L G CQ + W P C K++ C P I NG T A
Sbjct: 736 RVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLC-KVIHCHPPPVIVNGKHTGMMA 794
Query: 722 -GFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEP---CLNPGVP 777
F G+ V Y C G+ L G L C S G WS P+C L+ P C NP V
Sbjct: 795 ENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQC-LRSPPVTRCPNPEV- 852
Query: 778 ENGYQTLYKHH--YQAGESLRFFCYEGFELIGEVTITC------VPGHPS----QWTSQP 825
++GY+ L K H Y + + C GF + G I C VPG P+ + P
Sbjct: 853 KHGYK-LNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCP 911
Query: 826 PLCKVTQTTDPSRQLEGGNLA 846
P K P+ GGN+A
Sbjct: 912 PPPKT-----PNGNHTGGNIA 927
Score = 63.5 bits (153), Expect = 8e-10
Identities = 49/162 (30%), Positives = 67/162 (41%), Gaps = 17/162 (10%)
Query: 670 YQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD-AGFPVGSH 728
+ C G+ L GS + C +W + P C+K C P I NG + F G+
Sbjct: 377 FACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK--ECQAPPNILNGQKEDRHMVRFDPGTS 434
Query: 729 VQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHH 788
++Y C PGY L G + C S W+ VP+C K C G Q L K
Sbjct: 435 IKYSCNPGYVLVGEESIQCTSEGV----WTPPVPQC--KVAAC-----EATGRQLLTKPQ 483
Query: 789 YQ-AGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCK 829
+Q + C EG++L G V C P W + LCK
Sbjct: 484 HQFVRPDVNSSCGEGYKLSGSVYQECQGTIP--WFMEIRLCK 523
Score = 63.2 bits (152), Expect = 1e-09
Identities = 53/176 (30%), Positives = 70/176 (39%), Gaps = 20/176 (11%)
Query: 665 GTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFP 724
GT + Y C PGY L+G + + C + W+ P C K+ C G T F
Sbjct: 432 GTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC-KVAACEATGRQL---LTKPQHQF- 486
Query: 725 VGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT- 783
V V C GY L G+ C GT W + C K C P V NG T
Sbjct: 487 VRPDVNSSCGEGYKLSGSVYQEC----QGTIPWFMEIRLC--KEITCPPPPVIYNGAHTG 540
Query: 784 LYKHHYQAGESLRFFCYEG------FELIGEVTITCVPGHPSQ--WTSQPPLCKVT 831
+ G ++ + C G F LIGE TI C + W+ PLCK++
Sbjct: 541 SSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLS 596
Score = 60.5 bits (145), Expect = 7e-09
Identities = 34/113 (30%), Positives = 50/113 (44%), Gaps = 3/113 (2%)
Query: 703 MTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVP 762
++C P I NG + VG+ ++Y C + L G L C ++D W P
Sbjct: 21 ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
Query: 763 KCAL--KYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC 813
KC KY C P VP GY+ Y+ G+S+ F C F + G ++ C
Sbjct: 81 KCEYFNKYSSCPEPIVP-GGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWC 132
Score = 39.3 bits (90), Expect = 0.017
Identities = 19/67 (28%), Positives = 35/67 (52%), Gaps = 2/67 (2%)
Query: 298 HGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNAT 357
H +V + PG + T+ C+SGY L GE+ + CL+ + W+ P+C + ++
Sbjct: 165 HTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGK--WSAVPPTCEEARCKSLGRFP 222
Query: 358 LGRIVSP 364
G++ P
Sbjct: 223 NGKVKEP 229
Score = 37.4 bits (85), Expect = 0.064
Identities = 19/67 (28%), Positives = 33/67 (49%), Gaps = 5/67 (7%)
Query: 287 LLSCGFPP---RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTR--PSWNGE 341
++ C PP H + + G ++ CD G+ L GE+ L C + ++ SW+G
Sbjct: 775 VIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGP 834
Query: 342 TPSCMAS 348
+P C+ S
Sbjct: 835 SPQCLRS 841
Score = 37.0 bits (84), Expect = 0.084
Identities = 18/61 (29%), Positives = 30/61 (49%), Gaps = 5/61 (8%)
Query: 288 LSCGFPPRPAHGDVS---VTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPS 344
+ C PP+ +G+ + + PG + + CD GY L GE L+C + +W+ P
Sbjct: 908 IGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTH--EGTWSQPAPH 965
Query: 345 C 345
C
Sbjct: 966 C 966
Score = 36.6 bits (83), Expect = 0.11
Identities = 18/62 (29%), Positives = 32/62 (51%), Gaps = 4/62 (6%)
Query: 288 LSCGFPPRPAHGDVSV--TDLHPGGTATFHCDSGYQLQGEETLICLNGTR--PSWNGETP 343
+SCG PP +G +S T + G + C ++L GE++L+C+ + +W+ P
Sbjct: 21 ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
Query: 344 SC 345
C
Sbjct: 81 KC 82
Score = 35.4 bits (80), Expect = 0.24
Identities = 21/67 (31%), Positives = 31/67 (46%), Gaps = 6/67 (8%)
Query: 290 CGFPPRPAHG---DVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSC- 345
C PP +G D + PG + + C+ GY L GEE++ C + W P C
Sbjct: 410 CQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCT--SEGVWTPPVPQCK 467
Query: 346 MASCGGT 352
+A+C T
Sbjct: 468 VAACEAT 474
Score = 32.3 bits (72), Expect = 2.1
Identities = 20/69 (28%), Positives = 27/69 (39%), Gaps = 17/69 (24%)
Query: 290 CGFPPRPAHGDVSVTDLHPGGTATFH---------CDSGYQLQGEETLICLNGTRPSWNG 340
C PP HG H GG F CD GY L G +++ C+ +W+
Sbjct: 661 CQSPPGLHHGR------HTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCM--PSGNWSP 712
Query: 341 ETPSCMASC 349
P C +C
Sbjct: 713 SAPRCEETC 721
>gi|27502413 CD46 antigen, complement regulatory protein isoform 7
precursor [Homo sapiens]
Length = 378
Score = 82.4 bits (202), Expect = 2e-15
Identities = 69/208 (33%), Positives = 94/208 (45%), Gaps = 26/208 (12%)
Query: 642 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 698
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 699 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 752
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 753 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 809
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 810 TITCVPGHPSQWTSQPPLCKVTQTTDPS 837
TI C S T PP+ K + PS
Sbjct: 267 TIVC----DSNSTWDPPVPKCLKVLPPS 290
Score = 53.5 bits (127), Expect = 9e-07
Identities = 36/125 (28%), Positives = 52/125 (41%), Gaps = 12/125 (9%)
Query: 723 FPVGSHVQYRCLPGYSLEG--AAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 778
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 779 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKVTQTTDPS 837
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+ T P
Sbjct: 114 NGT-------YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPP 166
Query: 838 RQLEG 842
+ G
Sbjct: 167 KIKNG 171
Score = 36.6 bits (83), Expect = 0.11
Identities = 19/70 (27%), Positives = 35/70 (50%), Gaps = 3/70 (4%)
Query: 664 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM--TCADPGEIANGHRTASDA 721
+ TV+ ++C+ G+ L GSD + C + +W P C K++ + P +++ T+S
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTT 307
Query: 722 GFPVGSHVQY 731
P S Y
Sbjct: 308 KSPASSASGY 317
Score = 34.7 bits (78), Expect = 0.42
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 314 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 345
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
Score = 34.7 bits (78), Expect = 0.42
Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 311 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 346
T F CD G+ L G +T++C + +W+ P C+
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCL 284
>gi|27502402 CD46 antigen, complement regulatory protein isoform 1
precursor [Homo sapiens]
Length = 392
Score = 82.4 bits (202), Expect = 2e-15
Identities = 69/208 (33%), Positives = 94/208 (45%), Gaps = 26/208 (12%)
Query: 642 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 698
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 699 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 752
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 753 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 809
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 810 TITCVPGHPSQWTSQPPLCKVTQTTDPS 837
TI C S T PP+ K + PS
Sbjct: 267 TIVC----DSNSTWDPPVPKCLKVLPPS 290
Score = 53.5 bits (127), Expect = 9e-07
Identities = 36/125 (28%), Positives = 52/125 (41%), Gaps = 12/125 (9%)
Query: 723 FPVGSHVQYRCLPGYSLEG--AAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 778
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 779 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKVTQTTDPS 837
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+ T P
Sbjct: 114 NGT-------YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPP 166
Query: 838 RQLEG 842
+ G
Sbjct: 167 KIKNG 171
Score = 36.2 bits (82), Expect = 0.14
Identities = 18/66 (27%), Positives = 34/66 (51%), Gaps = 3/66 (4%)
Query: 664 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM--TCADPGEIANGHRTASDA 721
+ TV+ ++C+ G+ L GSD + C + +W P C K++ + P +++ T+S
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTT 307
Query: 722 GFPVGS 727
P S
Sbjct: 308 KSPASS 313
Score = 34.7 bits (78), Expect = 0.42
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 314 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 345
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
Score = 34.7 bits (78), Expect = 0.42
Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 311 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 346
T F CD G+ L G +T++C + +W+ P C+
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCL 284
>gi|27502425 CD46 antigen, complement regulatory protein isoform 8
precursor [Homo sapiens]
Length = 385
Score = 82.4 bits (202), Expect = 2e-15
Identities = 69/208 (33%), Positives = 94/208 (45%), Gaps = 26/208 (12%)
Query: 642 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 698
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 699 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 752
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 753 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 809
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 810 TITCVPGHPSQWTSQPPLCKVTQTTDPS 837
TI C S T PP+ K + PS
Sbjct: 267 TIVC----DSNSTWDPPVPKCLKVLPPS 290
Score = 53.5 bits (127), Expect = 9e-07
Identities = 36/125 (28%), Positives = 52/125 (41%), Gaps = 12/125 (9%)
Query: 723 FPVGSHVQYRCLPGYSLEG--AAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 778
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 779 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKVTQTTDPS 837
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+ T P
Sbjct: 114 NGT-------YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPP 166
Query: 838 RQLEG 842
+ G
Sbjct: 167 KIKNG 171
Score = 36.6 bits (83), Expect = 0.11
Identities = 19/70 (27%), Positives = 35/70 (50%), Gaps = 3/70 (4%)
Query: 664 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM--TCADPGEIANGHRTASDA 721
+ TV+ ++C+ G+ L GSD + C + +W P C K++ + P +++ T+S
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTT 307
Query: 722 GFPVGSHVQY 731
P S Y
Sbjct: 308 KSPASSASGY 317
Score = 34.7 bits (78), Expect = 0.42
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 314 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 345
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
Score = 34.7 bits (78), Expect = 0.42
Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 311 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 346
T F CD G+ L G +T++C + +W+ P C+
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCL 284
>gi|27502423 CD46 antigen, complement regulatory protein isoform 2
precursor [Homo sapiens]
Length = 399
Score = 82.4 bits (202), Expect = 2e-15
Identities = 69/208 (33%), Positives = 94/208 (45%), Gaps = 26/208 (12%)
Query: 642 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 698
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 699 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 752
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 753 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 809
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 810 TITCVPGHPSQWTSQPPLCKVTQTTDPS 837
TI C S T PP+ K + PS
Sbjct: 267 TIVC----DSNSTWDPPVPKCLKVLPPS 290
Score = 53.5 bits (127), Expect = 9e-07
Identities = 36/125 (28%), Positives = 52/125 (41%), Gaps = 12/125 (9%)
Query: 723 FPVGSHVQYRCLPGYSLEG--AAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 778
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 779 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKVTQTTDPS 837
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+ T P
Sbjct: 114 NGT-------YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPP 166
Query: 838 RQLEG 842
+ G
Sbjct: 167 KIKNG 171
Score = 36.2 bits (82), Expect = 0.14
Identities = 18/66 (27%), Positives = 34/66 (51%), Gaps = 3/66 (4%)
Query: 664 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIM--TCADPGEIANGHRTASDA 721
+ TV+ ++C+ G+ L GSD + C + +W P C K++ + P +++ T+S
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTT 307
Query: 722 GFPVGS 727
P S
Sbjct: 308 KSPASS 313
Score = 34.7 bits (78), Expect = 0.42
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 314 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 345
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
Score = 34.7 bits (78), Expect = 0.42
Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 311 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM 346
T F CD G+ L G +T++C + +W+ P C+
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCL 284
>gi|27502421 CD46 antigen, complement regulatory protein isoform 13
precursor [Homo sapiens]
Length = 373
Score = 81.6 bits (200), Expect = 3e-15
Identities = 67/209 (32%), Positives = 93/209 (44%), Gaps = 24/209 (11%)
Query: 642 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 698
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 699 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 752
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 753 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 809
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 810 TITCVPGHPSQWTSQPPLCKVTQTTDPSR 838
TI C S W P C T+ ++
Sbjct: 267 TIVC--DSNSTWDPPVPKCLKVSTSSTTK 293
Score = 53.5 bits (127), Expect = 9e-07
Identities = 36/125 (28%), Positives = 52/125 (41%), Gaps = 12/125 (9%)
Query: 723 FPVGSHVQYRCLPGYSLEG--AAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 778
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 779 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKVTQTTDPS 837
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+ T P
Sbjct: 114 NGT-------YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPP 166
Query: 838 RQLEG 842
+ G
Sbjct: 167 KIKNG 171
Score = 36.6 bits (83), Expect = 0.11
Identities = 18/56 (32%), Positives = 30/56 (53%), Gaps = 4/56 (7%)
Query: 664 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCA---DPGEIANGHR 716
+ TV+ ++C+ G+ L GSD + C + +W P C K+ T + P A+G R
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGPR 303
Score = 35.0 bits (79), Expect = 0.32
Identities = 14/56 (25%), Positives = 24/56 (42%), Gaps = 2/56 (3%)
Query: 311 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEP 366
T F CD G+ L G +T++C + +W+ P C+ + + P P
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRP 304
Score = 34.7 bits (78), Expect = 0.42
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 314 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 345
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
>gi|27502417 CD46 antigen, complement regulatory protein isoform 10
precursor [Homo sapiens]
Length = 370
Score = 81.6 bits (200), Expect = 3e-15
Identities = 67/209 (32%), Positives = 93/209 (44%), Gaps = 24/209 (11%)
Query: 642 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 698
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 699 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 752
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 753 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 809
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 810 TITCVPGHPSQWTSQPPLCKVTQTTDPSR 838
TI C S W P C T+ ++
Sbjct: 267 TIVC--DSNSTWDPPVPKCLKVSTSSTTK 293
Score = 53.5 bits (127), Expect = 9e-07
Identities = 36/125 (28%), Positives = 52/125 (41%), Gaps = 12/125 (9%)
Query: 723 FPVGSHVQYRCLPGYSLEG--AAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 778
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 779 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKVTQTTDPS 837
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+ T P
Sbjct: 114 NGT-------YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPP 166
Query: 838 RQLEG 842
+ G
Sbjct: 167 KIKNG 171
Score = 36.2 bits (82), Expect = 0.14
Identities = 17/55 (30%), Positives = 30/55 (54%), Gaps = 4/55 (7%)
Query: 664 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCA---DPGEIANGH 715
+ TV+ ++C+ G+ L GSD + C + +W P C K+ T + P A+G+
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGY 302
Score = 35.8 bits (81), Expect = 0.19
Identities = 20/71 (28%), Positives = 32/71 (45%), Gaps = 4/71 (5%)
Query: 311 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-ASCGGTIHNATLGRIVSPEPGGA 369
T F CD G+ L G +T++C + +W+ P C+ S T + P+P
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEEG 308
Query: 370 VGPNLTCRWVI 380
+ +L WVI
Sbjct: 309 ILDSLDV-WVI 318
Score = 34.7 bits (78), Expect = 0.42
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 314 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 345
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
>gi|27502415 CD46 antigen, complement regulatory protein isoform 9
precursor [Homo sapiens]
Length = 363
Score = 81.6 bits (200), Expect = 3e-15
Identities = 67/209 (32%), Positives = 93/209 (44%), Gaps = 24/209 (11%)
Query: 642 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 698
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 699 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 752
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 753 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 809
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 810 TITCVPGHPSQWTSQPPLCKVTQTTDPSR 838
TI C S W P C T+ ++
Sbjct: 267 TIVC--DSNSTWDPPVPKCLKVSTSSTTK 293
Score = 53.5 bits (127), Expect = 9e-07
Identities = 36/125 (28%), Positives = 52/125 (41%), Gaps = 12/125 (9%)
Query: 723 FPVGSHVQYRCLPGYSLEG--AAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 778
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 779 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKVTQTTDPS 837
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+ T P
Sbjct: 114 NGT-------YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPP 166
Query: 838 RQLEG 842
+ G
Sbjct: 167 KIKNG 171
Score = 36.2 bits (82), Expect = 0.14
Identities = 17/55 (30%), Positives = 30/55 (54%), Gaps = 4/55 (7%)
Query: 664 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCA---DPGEIANGH 715
+ TV+ ++C+ G+ L GSD + C + +W P C K+ T + P A+G+
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGY 302
Score = 35.8 bits (81), Expect = 0.19
Identities = 20/71 (28%), Positives = 32/71 (45%), Gaps = 4/71 (5%)
Query: 311 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCM-ASCGGTIHNATLGRIVSPEPGGA 369
T F CD G+ L G +T++C + +W+ P C+ S T + P+P
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEEG 308
Query: 370 VGPNLTCRWVI 380
+ +L WVI
Sbjct: 309 ILDSLDV-WVI 318
Score = 34.7 bits (78), Expect = 0.42
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 314 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 345
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
>gi|27502407 CD46 antigen, complement regulatory protein isoform 3
precursor [Homo sapiens]
Length = 377
Score = 81.6 bits (200), Expect = 3e-15
Identities = 67/209 (32%), Positives = 93/209 (44%), Gaps = 24/209 (11%)
Query: 642 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 698
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 699 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 752
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 753 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 809
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 810 TITCVPGHPSQWTSQPPLCKVTQTTDPSR 838
TI C S W P C T+ ++
Sbjct: 267 TIVC--DSNSTWDPPVPKCLKVSTSSTTK 293
Score = 53.5 bits (127), Expect = 9e-07
Identities = 36/125 (28%), Positives = 52/125 (41%), Gaps = 12/125 (9%)
Query: 723 FPVGSHVQYRCLPGYSLEG--AAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 778
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 779 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKVTQTTDPS 837
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+ T P
Sbjct: 114 NGT-------YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPP 166
Query: 838 RQLEG 842
+ G
Sbjct: 167 KIKNG 171
Score = 36.6 bits (83), Expect = 0.11
Identities = 18/56 (32%), Positives = 30/56 (53%), Gaps = 4/56 (7%)
Query: 664 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCA---DPGEIANGHR 716
+ TV+ ++C+ G+ L GSD + C + +W P C K+ T + P A+G R
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGPR 303
Score = 35.0 bits (79), Expect = 0.32
Identities = 14/56 (25%), Positives = 24/56 (42%), Gaps = 2/56 (3%)
Query: 311 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEP 366
T F CD G+ L G +T++C + +W+ P C+ + + P P
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRP 304
Score = 34.7 bits (78), Expect = 0.42
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 314 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 345
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
>gi|24432108 CD46 antigen, complement regulatory protein isoform 4
precursor [Homo sapiens]
Length = 384
Score = 81.6 bits (200), Expect = 3e-15
Identities = 67/209 (32%), Positives = 93/209 (44%), Gaps = 24/209 (11%)
Query: 642 DTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPA 698
+TCP + P G ++G G + + C GY L+G +IL C+ S WS PP
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156
Query: 699 CQKIMTCADPGEIANGHRTASDAG-FPVGSHVQYRCLPG-----YSLEGAAMLTCYSRDT 752
C+K++ C P +I NG T S+ F V Y C P +SL G + + C
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSV 215
Query: 753 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTL---YKHHYQAGESLRFFCYEGFELIGEV 809
WS P+C K C P V ENG Q K +Y+A ++ F C +GF L G
Sbjct: 216 ----WSRAAPEC--KVVKCRFP-VVENGKQISGFGKKFYYKA--TVMFECDKGFYLDGSD 266
Query: 810 TITCVPGHPSQWTSQPPLCKVTQTTDPSR 838
TI C S W P C T+ ++
Sbjct: 267 TIVC--DSNSTWDPPVPKCLKVSTSSTTK 293
Score = 53.5 bits (127), Expect = 9e-07
Identities = 36/125 (28%), Positives = 52/125 (41%), Gaps = 12/125 (9%)
Query: 723 FPVGSHVQYRCLPGYSLEG--AAMLTCYSRDTGTPKWSDRVPK--CALKYEPCLNPGVPE 778
+ +G V Y+C GY A C T P D + C +P VP
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 779 NGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITC-VPGHPSQWTSQPPLCKVTQTTDPS 837
NG Y+ G + F C EG+ LIGE + C + G + W+ +PP+C+ T P
Sbjct: 114 NGT-------YEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPP 166
Query: 838 RQLEG 842
+ G
Sbjct: 167 KIKNG 171
Score = 36.6 bits (83), Expect = 0.11
Identities = 18/56 (32%), Positives = 30/56 (53%), Gaps = 4/56 (7%)
Query: 664 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCA---DPGEIANGHR 716
+ TV+ ++C+ G+ L GSD + C + +W P C K+ T + P A+G R
Sbjct: 249 KATVM-FECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGPR 303
Score = 35.0 bits (79), Expect = 0.32
Identities = 14/56 (25%), Positives = 24/56 (42%), Gaps = 2/56 (3%)
Query: 311 TATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEP 366
T F CD G+ L G +T++C + +W+ P C+ + + P P
Sbjct: 251 TVMFECDKGFYLDGSDTIVC--DSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRP 304
Score = 34.7 bits (78), Expect = 0.42
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 314 FHCDSGYQLQGEETLIC-LNGTRPSWNGETPSC 345
F C+ GY L GEE L C L G+ W+G+ P C
Sbjct: 125 FICNEGYYLIGEEILYCELKGSVAIWSGKPPIC 157
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.137 0.436
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,907,571
Number of Sequences: 37866
Number of extensions: 3173882
Number of successful extensions: 33498
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 355
Number of HSP's successfully gapped in prelim test: 1003
Number of HSP's that attempted gapping in prelim test: 17275
Number of HSP's gapped (non-prelim): 10357
length of query: 910
length of database: 18,247,518
effective HSP length: 111
effective length of query: 799
effective length of database: 14,044,392
effective search space: 11221469208
effective search space used: 11221469208
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.