Search of human proteins with 16306588

Search of human proteins with 16306588

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|16306588 F-box and leucine-rich repeat protein 4 [Homo
sapiens]
         (621 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|16306588 F-box and leucine-rich repeat protein 4 [Homo sapiens]   1270   0.0  
gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens]    119   1e-26
gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens]   112   1e-24
gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens]      93   6e-19
gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1 ...    81   3e-15
gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2 ...    70   6e-12
gi|16306576 F-box and leucine-rich repeat protein 6 isoform 1 [H...    69   1e-11
gi|190194416 F-box and leucine-rich repeat protein 15 [Homo sapi...    67   4e-11
gi|61742136 F-box and leucine-rich repeat protein 6 isoform 2 [H...    67   6e-11
gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens]    63   7e-10
gi|254039600 F-box and leucine-rich repeat protein 17 [Homo sapi...    61   4e-09
gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo ...    57   5e-08
gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens]     56   9e-08
gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens]     56   9e-08
gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo ...    56   1e-07
gi|164663798 antagonist of mitotic exit network 1 homolog [Homo ...    53   7e-07
gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens]    52   1e-06
gi|157168349 F-box and leucine-rich repeat protein 19 [Homo sapi...    40   0.005
gi|16306574 F-box and leucine-rich repeat protein 5 isoform 2 [H...    40   0.006
gi|16306572 F-box and leucine-rich repeat protein 5 isoform 1 [H...    40   0.006
gi|30089926 F-box only protein 11 isoform 1 [Homo sapiens]             39   0.011
gi|30089924 F-box only protein 11 isoform 2 [Homo sapiens]             39   0.011
gi|30089922 F-box only protein 11 isoform 3 [Homo sapiens]             39   0.011
gi|8922303 ATP5S-like [Homo sapiens]                                   38   0.024
gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [...    37   0.054
gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [...    36   0.092
gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens]    36   0.12 
gi|5453880 acidic (leucine-rich) nuclear phosphoprotein 32 famil...    36   0.12 
gi|222136647 F-box protein 47 [Homo sapiens]                           35   0.21 
gi|113205085 leucine rich repeat containing 31 [Homo sapiens]          35   0.27 

>gi|16306588 F-box and leucine-rich repeat protein 4 [Homo sapiens]
          Length = 621

 Score = 1270 bits (3287), Expect = 0.0
 Identities = 621/621 (100%), Positives = 621/621 (100%)

Query: 1   MSPVFPMLTVLTMFYYICLRRRARTATRGEMMNTHRAIESNSQTSPLNAEVVQYAKEVVD 60
           MSPVFPMLTVLTMFYYICLRRRARTATRGEMMNTHRAIESNSQTSPLNAEVVQYAKEVVD
Sbjct: 1   MSPVFPMLTVLTMFYYICLRRRARTATRGEMMNTHRAIESNSQTSPLNAEVVQYAKEVVD 60

Query: 61  FSSHYGSENSMSYTMWNLAGVPNVFPSSGDFTQTAVFRTYGTWWDQCPSASLPFKRTPPN 120
           FSSHYGSENSMSYTMWNLAGVPNVFPSSGDFTQTAVFRTYGTWWDQCPSASLPFKRTPPN
Sbjct: 61  FSSHYGSENSMSYTMWNLAGVPNVFPSSGDFTQTAVFRTYGTWWDQCPSASLPFKRTPPN 120

Query: 121 FQSQDYVELTFEQQVYPTAVHVLETYHPGAVIRILACSANPYSPNPPAEVRWEILWSERP 180
           FQSQDYVELTFEQQVYPTAVHVLETYHPGAVIRILACSANPYSPNPPAEVRWEILWSERP
Sbjct: 121 FQSQDYVELTFEQQVYPTAVHVLETYHPGAVIRILACSANPYSPNPPAEVRWEILWSERP 180

Query: 181 TKVNASQARQFKPCIKQINFPTNLIRLEVNSSLLEYYTELDAVVLHGVKDKPVLSLKTSL 240
           TKVNASQARQFKPCIKQINFPTNLIRLEVNSSLLEYYTELDAVVLHGVKDKPVLSLKTSL
Sbjct: 181 TKVNASQARQFKPCIKQINFPTNLIRLEVNSSLLEYYTELDAVVLHGVKDKPVLSLKTSL 240

Query: 241 IDMNDIEDDAYAEKDGCGMDSLNKKFSSAVLGEGPNNGYFDKLPYELIQLILNHLTLPDL 300
           IDMNDIEDDAYAEKDGCGMDSLNKKFSSAVLGEGPNNGYFDKLPYELIQLILNHLTLPDL
Sbjct: 241 IDMNDIEDDAYAEKDGCGMDSLNKKFSSAVLGEGPNNGYFDKLPYELIQLILNHLTLPDL 300

Query: 301 CRLAQTCKLLSQHCCDPLQYIHLNLQPYWAKLDDTSLEFLQSRCTLVQWLNLSWTGNRGF 360
           CRLAQTCKLLSQHCCDPLQYIHLNLQPYWAKLDDTSLEFLQSRCTLVQWLNLSWTGNRGF
Sbjct: 301 CRLAQTCKLLSQHCCDPLQYIHLNLQPYWAKLDDTSLEFLQSRCTLVQWLNLSWTGNRGF 360

Query: 361 ISVAGFSRFLKVCGSELVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFN 420
           ISVAGFSRFLKVCGSELVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFN
Sbjct: 361 ISVAGFSRFLKVCGSELVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFN 420

Query: 421 HIAKLCSLKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKK 480
           HIAKLCSLKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKK
Sbjct: 421 HIAKLCSLKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKK 480

Query: 481 LRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFL 540
           LRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFL
Sbjct: 481 LRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFL 540

Query: 541 TANRSVCDTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDN 600
           TANRSVCDTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDN
Sbjct: 541 TANRSVCDTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDN 600

Query: 601 RAVLELNASFPKVFIKKSFTQ 621
           RAVLELNASFPKVFIKKSFTQ
Sbjct: 601 RAVLELNASFPKVFIKKSFTQ 621


>gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens]
          Length = 423

 Score =  119 bits (297), Expect = 1e-26
 Identities = 104/394 (26%), Positives = 169/394 (42%), Gaps = 63/394 (15%)

Query: 282 KLPYELIQLILNHLTLPDLCRLAQTCKLLSQHCCDPLQYIHLNLQPYWAKLD-------- 333
           KLP EL+  I + L +  LCR AQ  K  +    D   +  ++L  +   ++        
Sbjct: 14  KLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFNFQIDVEGRVVENIS 73

Query: 334 -------------------DTSLEFLQSRCTLVQWLNLSWTGNRGFISVAGFSRFLKVCG 374
                              D+SL+     C  ++ LNL+        +    SRF     
Sbjct: 74  KRCGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFC---- 129

Query: 375 SELVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCSLKRLVLY 434
           S+L  L+L+    +  + L+ ISE C NL+ LNLS CD++       + + C   + +L 
Sbjct: 130 SKLKHLDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALVRGCRGLKALLL 189

Query: 435 R--TKVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIA--------------------- 471
           R  T++E  AL  I N+C EL  L+L SC  I D  V+                      
Sbjct: 190 RGCTQLEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQICRGCHRLQALCLSGCSNLTD 249

Query: 472 ---SMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRL 528
              + +G  C +L+ L+  RC ++T+ G   LA  C  LE++DL  C  +  ST    +L
Sbjct: 250 ASLTALGLNCPRLQILEAARCSHLTDAGFTLLARNCHELEKMDLEECILITDST--LIQL 307

Query: 529 AHQLPNLQKLFLTANRSVCDTDIDELA---CNCTRLQQLDILGTRMVSPASLRKLLESCK 585
           +   P LQ L L+    + D  I  L+   C   RL+ L++    +++  +L  L E+C+
Sbjct: 308 SIHCPKLQALSLSHCELITDDGILHLSNSTCGHERLRVLELDNCLLITDVALEHL-ENCR 366

Query: 586 DLSLLDVSFCSQIDNRAVLELNASFPKVFIKKSF 619
            L  L++  C Q+    +  + A  P V +   F
Sbjct: 367 GLERLELYDCQQVTRAGIKRMRAQLPHVKVHAYF 400



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 42/168 (25%), Positives = 80/168 (47%), Gaps = 10/168 (5%)

Query: 433 LYRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNI 492
           L   K+ +  LL I +F   L  ++L  C  I     I ++ G+  +++   DL+  +  
Sbjct: 10  LINKKLPKELLLRIFSF---LDIVTLCRCAQISKAWNILALDGSNWQRI---DLFNFQID 63

Query: 493 TENGIAE-LASGCP-LLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTD 550
            E  + E ++  C   L +L L  C  +  S+      A    N++ L L     + D+ 
Sbjct: 64  VEGRVVENISKRCGGFLRKLSLRGCIGVGDSS--LKTFAQNCRNIEHLNLNGCTKITDST 121

Query: 551 IDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQI 598
              L+  C++L+ LD+     ++ +SL+ + E C++L  L++S+C QI
Sbjct: 122 CYSLSRFCSKLKHLDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQI 169


>gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens]
          Length = 436

 Score =  112 bits (280), Expect = 1e-24
 Identities = 101/394 (25%), Positives = 164/394 (41%), Gaps = 63/394 (15%)

Query: 282 KLPYELIQLILNHLTLPDLCRLAQTCKLLSQHCCDPLQYIHLNLQPYWAKLD-------- 333
           KLP EL+  I + L +  LCR AQ  +  +    D   +  ++L  +   ++        
Sbjct: 27  KLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENIS 86

Query: 334 -------------------DTSLEFLQSRCTLVQWLNLSWTGNRGFISVAGFSRFLKVCG 374
                              D +L      C  ++ LNL+        +    S+F     
Sbjct: 87  KRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFC---- 142

Query: 375 SELVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLC-SLKRLVL 433
           S+L  L+L+    +    L+ +SE CP L+ LN+S CD++       + + C  LK L L
Sbjct: 143 SKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFL 202

Query: 434 YR-TKVEQTALLSILNFCSELQHLSLGSCVMIED------------------------YD 468
              T++E  AL  I   C EL  L+L +C+ I D                         D
Sbjct: 203 KGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITD 262

Query: 469 VIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRL 528
            I + +G  C +LR L++ RC  +T+ G   LA  C  LE++DL  C  +  ST    +L
Sbjct: 263 AILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDST--LIQL 320

Query: 529 AHQLPNLQKLFLTANRSVCDTDIDEL---ACNCTRLQQLDILGTRMVSPASLRKLLESCK 585
           +   P LQ L L+    + D  I  L   AC   +L+ +++    +++ ASL   L+SC 
Sbjct: 321 SIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEH-LKSCH 379

Query: 586 DLSLLDVSFCSQIDNRAVLELNASFPKVFIKKSF 619
            L  +++  C QI    +  L    P + +   F
Sbjct: 380 SLERIELYDCQQITRAGIKRLRTHLPNIKVHAYF 413


>gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens]
          Length = 491

 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 99/377 (26%), Positives = 157/377 (41%), Gaps = 84/377 (22%)

Query: 281 DKLPYELIQLILNHLTLPDLCRLAQTCKLLSQHCCDPLQYIHLNLQPYWAKLDDTSLEFL 340
           D+LP   +  I + L    LCR A+ C+       DP  +  + L      +D  +L+ L
Sbjct: 115 DRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVD-RALKVL 173

Query: 341 QSR--------CTLVQWLNLSWTG---NRGFISVAGFSRFLKVCGSELVRLELS-CSHFL 388
             R        C +++ + +S      +RG  ++A        C  EL RLE+S C +  
Sbjct: 174 TRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQ-------CCPELRRLEVSGCYNIS 226

Query: 389 NETCLEVISEMCPNLQALNLSSCDK----------------------------------L 414
           NE   +V+S +CPNL+ L++S C K                                  L
Sbjct: 227 NEAVFDVVS-LCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVL 285

Query: 415 PPQAFNHIAKLCS-LKRLVLYR-TKVEQTALLSILNFCSELQHLSLGSCVMIEDY----- 467
             +  + IA  C+ L  L L R  ++    L  ++ +C+ ++ LS+  C  + D+     
Sbjct: 286 EDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREI 345

Query: 468 -------------------DVIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLE 508
                              DV    +   C KLR L+   C+ IT++G+  LA  C  L+
Sbjct: 346 AKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLK 405

Query: 509 ELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILG 568
            LD+G CP L S TG    LA    NL++L L +  S+    +  +A NC  LQ L++  
Sbjct: 406 SLDIGKCP-LVSDTG-LECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQD 463

Query: 569 TRMVSPASLRKLLESCK 585
              VS  +LR +   CK
Sbjct: 464 CE-VSVEALRFVKRHCK 479



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 27/105 (25%), Positives = 49/105 (46%), Gaps = 7/105 (6%)

Query: 332 LDDTSLEFLQSRCTLVQWLNLSWTGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNET 391
           + D  +E+L   CT ++ L++   G    +S  G       C + L RL L     +   
Sbjct: 389 ITDHGVEYLAKNCTKLKSLDI---GKCPLVSDTGLECLALNCFN-LKRLSLKSCESITGQ 444

Query: 392 CLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCSLKRLVLYRT 436
            L++++  C +LQ LN+  C+ +  +A   + + C  KR V+  T
Sbjct: 445 GLQIVAANCFDLQTLNVQDCE-VSVEALRFVKRHC--KRCVIEHT 486


>gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1
           [Homo sapiens]
          Length = 735

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 64/245 (26%), Positives = 104/245 (42%), Gaps = 32/245 (13%)

Query: 365 GFSRFLKVCGSELVR-LELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIA 423
           G  +FL    S  +R L LS    L++  +  +SE CPNL  L+L +C+ L  Q   +I 
Sbjct: 468 GLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIV 527

Query: 424 KLCSLKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRT 483
            + SL  + L  T +    L  +                             ++ KKL+ 
Sbjct: 528 NIFSLVSIDLSGTDISNEGLNVL-----------------------------SRHKKLKE 558

Query: 484 LDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTAN 543
           L +  C  IT++GI        +LE LD+ +C  L  S      LA    NL  L +   
Sbjct: 559 LSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQL--SDMIIKALAIYCINLTSLSIAGC 616

Query: 544 RSVCDTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAV 603
             + D+ ++ L+  C  L  LDI G  +++   L  L   CK L +L + +C+ I  +A 
Sbjct: 617 PKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAA 676

Query: 604 LELNA 608
             +++
Sbjct: 677 QRMSS 681



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 53/209 (25%), Positives = 93/209 (44%), Gaps = 5/209 (2%)

Query: 400 CPNLQALNLSSCDKLPPQAFNHIAKLC-SLKRLVLYRTKVEQTALLSILNFCSELQHLSL 458
           C NLQ LN+S C     ++  HI++ C  +  L L  T +    +  +      LQ+LSL
Sbjct: 244 CRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSL 303

Query: 459 GSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTL 518
             C    D  +    +G  C KL  LDL  C  I+  G   +A+ C  +  L +   PTL
Sbjct: 304 AYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTL 363

Query: 519 QSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILGTRMVSPASLR 578
             +  C   L  +   +  L  T    + D      A +  +L+++   G + V+ AS +
Sbjct: 364 --TDNCVKALVEKCSRITSLVFTGAPHISDCTF--RALSACKLRKIRFEGNKRVTDASFK 419

Query: 579 KLLESCKDLSLLDVSFCSQIDNRAVLELN 607
            + ++  +LS + ++ C  I + ++  L+
Sbjct: 420 FIDKNYPNLSHIYMADCKGITDSSLRSLS 448


>gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2
           [Homo sapiens]
          Length = 690

 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 49/160 (30%), Positives = 77/160 (48%), Gaps = 7/160 (4%)

Query: 365 GFSRFLKVCGSELVR-LELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIA 423
           G  +FL    S  +R L LS    L++  +  +SE CPNL  L+L +C+ L  Q   +I 
Sbjct: 468 GLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIV 527

Query: 424 KLCSLKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIED-----YDVIASMIGAKC 478
            + SL  + L  T +     L++L+   +L+ LS+  C  I D      D    M+ AKC
Sbjct: 528 NIFSLVSIDLSGTDISNEG-LNVLSRHKKLKELSVSECYRITDDGIQITDSAMEMLSAKC 586

Query: 479 KKLRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTL 518
             L  LD+  C  +T+  + +L  GC  L  L + +C  +
Sbjct: 587 HYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNI 626



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 53/209 (25%), Positives = 93/209 (44%), Gaps = 5/209 (2%)

Query: 400 CPNLQALNLSSCDKLPPQAFNHIAKLC-SLKRLVLYRTKVEQTALLSILNFCSELQHLSL 458
           C NLQ LN+S C     ++  HI++ C  +  L L  T +    +  +      LQ+LSL
Sbjct: 244 CRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSL 303

Query: 459 GSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTL 518
             C    D  +    +G  C KL  LDL  C  I+  G   +A+ C  +  L +   PTL
Sbjct: 304 AYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTL 363

Query: 519 QSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILGTRMVSPASLR 578
             +  C   L  +   +  L  T    + D      A +  +L+++   G + V+ AS +
Sbjct: 364 --TDNCVKALVEKCSRITSLVFTGAPHISDCTF--RALSACKLRKIRFEGNKRVTDASFK 419

Query: 579 KLLESCKDLSLLDVSFCSQIDNRAVLELN 607
            + ++  +LS + ++ C  I + ++  L+
Sbjct: 420 FIDKNYPNLSHIYMADCKGITDSSLRSLS 448



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 67/304 (22%), Positives = 131/304 (43%), Gaps = 26/304 (8%)

Query: 315 CDPLQYIHLNLQPYWAKLDDTSLEFLQSRCTLVQWLNLSWTGNRGFISVAGFSRFLKVCG 374
           C  + ++ +N  P    L D  ++ L  +C+ +   +L +TG    IS   F R L  C 
Sbjct: 349 CTGIMHLTINDMP---TLTDNCVKALVEKCSRIT--SLVFTG-APHISDCTF-RALSACK 401

Query: 375 SELVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCSLKRLVLY 434
              +R E   +  + +   + I +  PNL  + ++ C  +   +   ++ L  L  L L 
Sbjct: 402 LRKIRFE--GNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLA 459

Query: 435 R-TKVEQTALLSILN--FCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKN 491
              ++    L   L+      ++ L+L +CV + D  V+   +  +C  L  L L  C++
Sbjct: 460 NCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMK--LSERCPNLNYLSLRNCEH 517

Query: 492 ITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTA-------NR 544
           +T  GI  + +   L+  +DL             +R  H+   L++L ++          
Sbjct: 518 LTAQGIGYIVNIFSLVS-IDLSGTDISNEGLNVLSR--HK--KLKELSVSECYRITDDGI 572

Query: 545 SVCDTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVL 604
            + D+ ++ L+  C  L  LDI G  +++   L  L   CK L +L + +C+ I  +A  
Sbjct: 573 QITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQ 632

Query: 605 ELNA 608
            +++
Sbjct: 633 RMSS 636


>gi|16306576 F-box and leucine-rich repeat protein 6 isoform 1 [Homo
           sapiens]
          Length = 539

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 84/353 (23%), Positives = 142/353 (40%), Gaps = 39/353 (11%)

Query: 273 EGPNNGYFDKLPYELIQLILNHLT-----LPDLCRLAQTCKLLSQHCCDPLQYIHLNL-Q 326
           EGP+ G+ D++P E++  I   L      +P L R A+ C+   +    P  +  + L  
Sbjct: 105 EGPDAGWGDRIPLEILVQIFGLLVAADGPMPFLGRAARVCRRWQEAASQPALWHTVTLSS 164

Query: 327 PYWAKLDDTSLEFLQSRCTLVQWLNLSWTGNRGFISVAGFSRFLKVCGSELVRLELSCSH 386
           P   +     ++  +     ++WL                +RF     S+L RL L    
Sbjct: 165 PLVGRPAKGGVKAEKKLLASLEWLMP--------------NRF-----SQLQRLTLIHWK 205

Query: 387 FLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAK-LCSLKRLVLYRTKVEQTALLS 445
                 L+++ E CP L  L LS C  +   A   +AK  C L  L L  + VE TA++S
Sbjct: 206 SQVHPVLKLVGECCPRLTFLKLSGCHGVTADALVMLAKACCQLHSLDLQHSMVESTAVVS 265

Query: 446 ILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGI------AE 499
            L          L      +   ++ +++G+ C +L+ L++     I  N I        
Sbjct: 266 FLEEAGSRMR-KLWLTYSSQTTAILGALLGSCCPQLQVLEV--STGINRNSIPLQLPVEA 322

Query: 500 LASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTAN--RSVCDTDIDELACN 557
           L  GCP L+ L L     L    G         P+L++L L ++    V +  +  L   
Sbjct: 323 LQKGCPQLQVLRLLNLMWLPKPPGRGVAPGPGFPSLEELCLASSTCNFVSNEVLGRLLHG 382

Query: 558 CTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLELNASF 610
              L+ LD+ G   ++PA L+ L   C++L  L +      D   + +  + F
Sbjct: 383 SPNLRLLDLRGCARITPAGLQDL--PCRELEQLHLGLYGTSDRLTLAKEGSPF 433



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 70/308 (22%), Positives = 122/308 (39%), Gaps = 43/308 (13%)

Query: 314 CCDPLQYIHLNLQPYWAKLDDTSLEFLQSRCTLVQWLNLSWTGNRGFISVAGFSRFLKVC 373
           CC  L ++ L+       +   +L  L   C  +  L+L        +       FL+  
Sbjct: 218 CCPRLTFLKLS---GCHGVTADALVMLAKACCQLHSLDLQ----HSMVESTAVVSFLEEA 270

Query: 374 GSELVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCD-------KLPPQAFNHIAKLC 426
           GS + +L L+ S         ++   CP LQ L +S+         +LP +A        
Sbjct: 271 GSRMRKLWLTYSSQTTAILGALLGSCCPQLQVLEVSTGINRNSIPLQLPVEALQKGCPQL 330

Query: 427 SLKRLV--LYRTKVEQTALLSILNFCSELQHLSLGS--CVMIEDYDVIASMIGAKCKKLR 482
            + RL+  ++  K     +     F S L+ L L S  C  + + +V+  ++      LR
Sbjct: 331 QVLRLLNLMWLPKPPGRGVAPGPGFPS-LEELCLASSTCNFVSN-EVLGRLLHGS-PNLR 387

Query: 483 TLDLWRCKNITENGIAELASGCPLLEELDLGWCPTL-------QSSTGCFTRLAHQLPNL 535
            LDL  C  IT  G+ +L   C  LE+L LG   T        + S     +  H L  L
Sbjct: 388 LLDLRGCARITPAGLQDLP--CRELEQLHLGLYGTSDRLTLAKEGSPFLTQKWCHTLREL 445

Query: 536 QKLFLTANRSVCDTDIDELAC--------NCTRLQQLDILGTRMVSPASLRKLLESCKDL 587
                 + +   + D+++           +   L  L++ GTR V+P+++  ++ SC  L
Sbjct: 446 D----LSGQGFSEKDLEQALAAFLSTPGGSHPALCSLNLRGTR-VTPSTVSSVISSCPGL 500

Query: 588 SLLDVSFC 595
             L++  C
Sbjct: 501 LYLNLESC 508



 Score = 30.0 bits (66), Expect = 6.6
 Identities = 33/107 (30%), Positives = 42/107 (39%), Gaps = 7/107 (6%)

Query: 315 CDPLQYIHLNLQPYWAKLD---DTSLEFLQSRCTLVQWLNLSWTGNRGFISVAGFSRFLK 371
           C  L+ +HL L     +L    + S    Q  C  ++ L+LS  G          + FL 
Sbjct: 407 CRELEQLHLGLYGTSDRLTLAKEGSPFLTQKWCHTLRELDLSGQGFSEKDLEQALAAFLS 466

Query: 372 VCGSE---LVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLP 415
             G     L  L L  +     T   VIS  CP L  LNL SC  LP
Sbjct: 467 TPGGSHPALCSLNLRGTRVTPSTVSSVISS-CPGLLYLNLESCRCLP 512


>gi|190194416 F-box and leucine-rich repeat protein 15 [Homo
           sapiens]
          Length = 300

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 50/164 (30%), Positives = 73/164 (44%), Gaps = 3/164 (1%)

Query: 443 LLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELAS 502
           L+ +L    +L+ ++LG C  +    + A   G  C +L+ L L  C  +    +  LA 
Sbjct: 106 LVPVLARNPQLRSVALGGCGQLSRRALGALAEG--CPRLQRLSLAHCDWVDGLALRGLAD 163

Query: 503 GCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQ 562
            CP LEELDL  C  L+     +     +   L+ L L  N +V D  + ELA NC  L 
Sbjct: 164 RCPALEELDLTACRQLKDEAIVYLA-QRRGAGLRSLSLAVNANVGDAAVQELARNCPELH 222

Query: 563 QLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLEL 606
            LD+ G   V    +R L E C  L  L V  C  +   ++  L
Sbjct: 223 HLDLTGCLRVGSDGVRTLAEYCPVLRSLRVRHCHHVAESSLSRL 266



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 44/167 (26%), Positives = 70/167 (41%), Gaps = 27/167 (16%)

Query: 388 LNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCSLKRLVLYRTKVEQTALLSIL 447
           L+   L  ++E CP LQ L+L+ CD                         V+  AL  + 
Sbjct: 127 LSRRALGALAEGCPRLQRLSLAHCD------------------------WVDGLALRGLA 162

Query: 448 NFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLL 507
           + C  L+ L L +C  ++D + I  +   +   LR+L L    N+ +  + ELA  CP L
Sbjct: 163 DRCPALEELDLTACRQLKD-EAIVYLAQRRGAGLRSLSLAVNANVGDAAVQELARNCPEL 221

Query: 508 EELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDEL 554
             LDL  C  L+  +     LA   P L+ L +     V ++ +  L
Sbjct: 222 HHLDLTGC--LRVGSDGVRTLAEYCPVLRSLRVRHCHHVAESSLSRL 266



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 34/127 (26%), Positives = 63/127 (49%), Gaps = 5/127 (3%)

Query: 377 LVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKL--CSLKRLVL- 433
           L RL L+   +++   L  +++ CP L+ L+L++C +L  +A  ++A+     L+ L L 
Sbjct: 142 LQRLSLAHCDWVDGLALRGLADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLA 201

Query: 434 YRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNIT 493
               V   A+  +   C EL HL L  C+ +    V    +   C  LR+L +  C ++ 
Sbjct: 202 VNANVGDAAVQELARNCPELHHLDLTGCLRVGSDGV--RTLAEYCPVLRSLRVRHCHHVA 259

Query: 494 ENGIAEL 500
           E+ ++ L
Sbjct: 260 ESSLSRL 266


>gi|61742136 F-box and leucine-rich repeat protein 6 isoform 2 [Homo
           sapiens]
          Length = 533

 Score = 66.6 bits (161), Expect = 6e-11
 Identities = 84/353 (23%), Positives = 144/353 (40%), Gaps = 45/353 (12%)

Query: 273 EGPNNGYFDKLPYELIQLILNHLT-----LPDLCRLAQTCKLLSQHCCDPLQYIHLNL-Q 326
           EGP+ G+ D++P E++  I   L      +P L R A+ C+   +    P  +  + L  
Sbjct: 105 EGPDAGWGDRIPLEILVQIFGLLVAADGPMPFLGRAARVCRRWQEAASQPALWHTVTLSS 164

Query: 327 PYWAKLDDTSLEFLQSRCTLVQWLNLSWTGNRGFISVAGFSRFLKVCGSELVRLELSCSH 386
           P   +     ++  +     ++WL                +RF     S+L RL L   H
Sbjct: 165 PLVGRPAKGGVKAEKKLLASLEWLMP--------------NRF-----SQLQRLTL--IH 203

Query: 387 FLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAK-LCSLKRLVLYRTKVEQTALLS 445
           + +    +++ E CP L  L LS C  +   A   +AK  C L  L L  + VE TA++S
Sbjct: 204 WKS----QLVGECCPRLTFLKLSGCHGVTADALVMLAKACCQLHSLDLQHSMVESTAVVS 259

Query: 446 ILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGI------AE 499
            L          L      +   ++ +++G+ C +L+ L++     I  N I        
Sbjct: 260 FLEEAGSRMR-KLWLTYSSQTTAILGALLGSCCPQLQVLEV--STGINRNSIPLQLPVEA 316

Query: 500 LASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTAN--RSVCDTDIDELACN 557
           L  GCP L+ L L     L    G         P+L++L L ++    V +  +  L   
Sbjct: 317 LQKGCPQLQVLRLLNLMWLPKPPGRGVAPGPGFPSLEELCLASSTCNFVSNEVLGRLLHG 376

Query: 558 CTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLELNASF 610
              L+ LD+ G   ++PA L+ L   C++L  L +      D   + +  + F
Sbjct: 377 SPNLRLLDLRGCARITPAGLQDL--PCRELEQLHLGLYGTSDRLTLAKEGSPF 427



 Score = 30.0 bits (66), Expect = 6.6
 Identities = 33/107 (30%), Positives = 42/107 (39%), Gaps = 7/107 (6%)

Query: 315 CDPLQYIHLNLQPYWAKLD---DTSLEFLQSRCTLVQWLNLSWTGNRGFISVAGFSRFLK 371
           C  L+ +HL L     +L    + S    Q  C  ++ L+LS  G          + FL 
Sbjct: 401 CRELEQLHLGLYGTSDRLTLAKEGSPFLTQKWCHTLRELDLSGQGFSEKDLEQALAAFLS 460

Query: 372 VCGSE---LVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLP 415
             G     L  L L  +     T   VIS  CP L  LNL SC  LP
Sbjct: 461 TPGGSHPALCSLNLRGTRVTPSTVSSVISS-CPGLLYLNLESCRCLP 506


>gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens]
          Length = 418

 Score = 63.2 bits (152), Expect = 7e-10
 Identities = 57/221 (25%), Positives = 106/221 (47%), Gaps = 15/221 (6%)

Query: 393 LEVISEMCPNLQALNLSSCDKLPPQAFNH--IAKLCSLKRLVLYRTK-VEQTALLSILNF 449
           L  + +   N+++LNLS C  L      H  + ++ SL+ L L   K +  ++L  I  +
Sbjct: 82  LSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQY 141

Query: 450 CSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAEL-------AS 502
              L+ L LG C  I +  ++  +I    ++L++L+L  C+++++ GI  L       A 
Sbjct: 142 LKGLEVLELGGCSNITNTGLL--LIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAE 199

Query: 503 GCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQ 562
           GC  LE+L L  C  L   +     ++  L  L+ L L+    + D  +  L+ +   L+
Sbjct: 200 GCLGLEQLTLQDCQKLTDLS--LKHISRGLTGLRLLNLSFCGGISDAGLLHLS-HMGSLR 256

Query: 563 QLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAV 603
            L++     +S   +  L      LS LDVSFC ++ ++++
Sbjct: 257 SLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSL 297



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 72/264 (27%), Positives = 122/264 (46%), Gaps = 21/264 (7%)

Query: 350 LNLSWTGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNETCLEVISEMCPNLQALNLS 409
           LNLS        S+   +++LK  G E++ L   CS+  N T L +I+     L++LNL 
Sbjct: 122 LNLSLCKQITDSSLGRIAQYLK--GLEVLELG-GCSNITN-TGLLLIAWGLQRLKSLNLR 177

Query: 410 SCDKLPPQAFNHIAKLC--------SLKRLVLYRT-KVEQTALLSILNFCSELQHLSLGS 460
           SC  L      H+A +          L++L L    K+   +L  I    + L+ L+L  
Sbjct: 178 SCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSF 237

Query: 461 CVMIEDYDVI-ASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQ 519
           C  I D  ++  S +G+    LR+L+L  C NI++ GI  LA G   L  LD+ +C  + 
Sbjct: 238 CGGISDAGLLHLSHMGS----LRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVG 293

Query: 520 SSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILGTRMVSPASLRK 579
             +  +  +A  L  L+ L L  +  + D  I+ +      L+ L+I     ++   L  
Sbjct: 294 DQSLAY--IAQGLDGLKSLSL-CSCHISDDGINRMVRQMHGLRTLNIGQCVRITDKGLEL 350

Query: 580 LLESCKDLSLLDVSFCSQIDNRAV 603
           + E    L+ +D+  C++I  R +
Sbjct: 351 IAEHLSQLTGIDLYGCTRITKRGL 374



 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 47/173 (27%), Positives = 84/173 (48%), Gaps = 10/173 (5%)

Query: 442 ALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELA 501
           +L  ++   + ++ L+L  C  + D  +  + +  +   LR L+L  CK IT++ +  +A
Sbjct: 81  SLSYVIQGMANIESLNLSGCYNLTDNGLGHAFV-QEIGSLRALNLSLCKQITDSSLGRIA 139

Query: 502 SGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELAC----- 556
                LE L+LG C  + ++TG    +A  L  L+ L L + R + D  I  LA      
Sbjct: 140 QYLKGLEVLELGGCSNI-TNTGLLL-IAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSA 197

Query: 557 --NCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLELN 607
              C  L+QL +   + ++  SL+ +      L LL++SFC  I +  +L L+
Sbjct: 198 AEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLS 250


>gi|254039600 F-box and leucine-rich repeat protein 17 [Homo
           sapiens]
          Length = 303

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 68/266 (25%), Positives = 117/266 (43%), Gaps = 22/266 (8%)

Query: 298 PDLCRL-AQTCKLLSQHC-------CDPLQYIHLNLQPYWAKLDDTSLEFLQSRCTLVQW 349
           P L R  A  CK LS          C  LQ +H+  Q    KL D  L+ L S+C  ++ 
Sbjct: 14  PGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQD---KLTDEGLKQLGSKCRELKD 70

Query: 350 LNLSWTGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNETCLEVISEMCPNLQALNLS 409
           ++    G    IS  G     K C  +L R+ +  +  + +  ++  +E CP LQ +   
Sbjct: 71  IHF---GQCYKISDEGMIVIAKGC-LKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFM 126

Query: 410 SCDKLPPQAFNHIAKLCSLKRLVL-YRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYD 468
            C  +  +   H+ KL +L  L L + T+++   ++ I+  C  L  L+L  C+     D
Sbjct: 127 GC-SVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNL--CLNWIIND 183

Query: 469 VIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRL 528
               +I  + + L+ L L  CK IT+  +  +      +E +D+GWC  +       T +
Sbjct: 184 RCVEVIAKEGQNLKELYLVSCK-ITDYALIAIGRYSMTIETVDVGWCKEITDQGA--TLI 240

Query: 529 AHQLPNLQKLFLTANRSVCDTDIDEL 554
           A    +L+ L L     V +  +++L
Sbjct: 241 AQSSKSLRYLGLMRCDKVNEVTVEQL 266



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 39/159 (24%), Positives = 71/159 (44%), Gaps = 28/159 (17%)

Query: 473 MIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDLG---------------WCPT 517
           ++  KC  L     +RCK +++  I  +AS CPLL+++ +G                C  
Sbjct: 8   VLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRE 67

Query: 518 LQ----------SSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDIL 567
           L+          S  G    +A     LQ++++  N+ V D  +   A +C  LQ +  +
Sbjct: 68  LKDIHFGQCYKISDEGMIV-IAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFM 126

Query: 568 GTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLEL 606
           G  + S   +   L   ++LS LD+   +++DN  V+E+
Sbjct: 127 GCSVTSKGVIH--LTKLRNLSSLDLRHITELDNETVMEI 163



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 46/250 (18%), Positives = 102/250 (40%), Gaps = 27/250 (10%)

Query: 388 LNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCSLKRLVLYRT--KVEQTALLS 445
           L++T +  ++  CP LQ +++ + DKL  +    +   C   + + +    K+    ++ 
Sbjct: 27  LSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIV 86

Query: 446 ILNFCSELQHLSLGSCVMIEDYDVIA--------SMIG--------------AKCKKLRT 483
           I   C +LQ + +    ++ D  V A          +G               K + L +
Sbjct: 87  IAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSS 146

Query: 484 LDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTAN 543
           LDL     +    + E+   C  L  L+L  C     +  C   +A +  NL++L+L + 
Sbjct: 147 LDLRHITELDNETVMEIVKRCKNLSSLNL--CLNWIINDRCVEVIAKEGQNLKELYLVSC 204

Query: 544 RSVCDTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAV 603
           + + D  +  +      ++ +D+   + ++      + +S K L  L +  C +++   V
Sbjct: 205 K-ITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTV 263

Query: 604 LELNASFPKV 613
            +L   +P +
Sbjct: 264 EQLVQQYPHI 273



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 38/160 (23%), Positives = 63/160 (39%), Gaps = 41/160 (25%)

Query: 377 LVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCSLKRLVLYRT 436
           L  L L  +  +N+ C+EVI++   NL+ L L SC                         
Sbjct: 170 LSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSC------------------------- 204

Query: 437 KVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENG 496
           K+   AL++I  +   ++ + +G C  I D    A++I    K LR L L RC  + E  
Sbjct: 205 KITDYALIAIGRYSMTIETVDVGWCKEITDQG--ATLIAQSSKSLRYLGLMRCDKVNEVT 262

Query: 497 IAELASGCP--------------LLEELDLGWCPTLQSST 522
           + +L    P              L     +GW P + +++
Sbjct: 263 VEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNMSAAS 302


>gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo
           sapiens]
          Length = 424

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 83/309 (26%), Positives = 129/309 (41%), Gaps = 70/309 (22%)

Query: 280 FDKLPYELIQLILNHLTLPDLCRLAQTCK-----------------------------LL 310
           +D LP EL+  I + L LP+L +++  CK                             LL
Sbjct: 97  WDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLL 156

Query: 311 SQHCC-----------------DPLQYIHLNLQPYWAKLDDTSLEFLQSRCTLVQWLNLS 353
           SQ                     P +  H++L    + ++ ++L  + S+C+ +Q  NLS
Sbjct: 157 SQGVIAFRCPRSFMDQPLAEHFSPFRVQHMDLSN--SVIEVSTLHGILSQCSKLQ--NLS 212

Query: 354 WTGNRGFISVAGFSRFLKVCGSELVRLELS-CSHFLNETCLEVISEMCPNLQALNLSSC- 411
             G R  +S    +   K   S LVRL LS CS F +E  L+ +   C  L  LNLS C 
Sbjct: 213 LEGLR--LSDPIVNTLAK--NSNLVRLNLSGCSGF-SEFALQTLLSSCSRLDELNLSWCF 267

Query: 412 ---DKLPPQAFNHIAKLCSLKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYD 468
              +K    A  H+++  +   L  YR  ++++ L +++  C  L HL L   VM+++ D
Sbjct: 268 DFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKN-D 326

Query: 469 VIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDL-GWCPTLQSSTGCFTR 527
                   +   L+ L L RC +I    + EL    P L+ L + G  P      G    
Sbjct: 327 CFQEFF--QLNYLQHLSLSRCYDIIPETLLELGE-IPTLKTLQVFGIVP-----DGTLQL 378

Query: 528 LAHQLPNLQ 536
           L   LP+LQ
Sbjct: 379 LKEALPHLQ 387



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 50/180 (27%), Positives = 84/180 (46%), Gaps = 7/180 (3%)

Query: 428 LKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLW 487
           ++ + L  + +E + L  IL+ CS+LQ+LSL    +    D I + + AK   L  L+L 
Sbjct: 183 VQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLS---DPIVNTL-AKNSNLVRLNLS 238

Query: 488 RCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANR-SV 546
            C   +E  +  L S C  L+EL+L WC    +       +AH    + +L L+  R ++
Sbjct: 239 GCSGFSEFALQTLLSSCSRLDELNLSWCFDF-TEKHVQVAVAHVSETITQLNLSGYRKNL 297

Query: 547 CDTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLEL 606
             +D+  L   C  L  LD+  + M+     ++  +    L  L +S C  I    +LEL
Sbjct: 298 QKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQ-LNYLQHLSLSRCYDIIPETLLEL 356


>gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens]
          Length = 223

 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 48/161 (29%), Positives = 69/161 (42%), Gaps = 31/161 (19%)

Query: 453 LQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDL 512
           LQ L L +C  + D  +   +   +  +LR L L     +T+NG+  +A GCP LE L L
Sbjct: 77  LQELDLTACSKLTDASLAKVL---QFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLAL 133

Query: 513 GWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILGTRMV 572
             C  L      + + A   P LQ L    N S C   I+         Q LD +G    
Sbjct: 134 SHCSRLSDKG--WAQAASSWPRLQHL----NLSSCSQLIE---------QTLDAIG---- 174

Query: 573 SPASLRKLLESCKDLSLLDVSFCSQIDNRAVLELNASFPKV 613
                    ++C+ L +LDV+ C  I+  AV    A  P+V
Sbjct: 175 ---------QACRQLRVLDVATCPGINMAAVRRFQAQLPQV 206



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 38/108 (35%), Positives = 52/108 (48%), Gaps = 15/108 (13%)

Query: 330 AKLDDTSL----EFLQSRCTLVQWLNLSWTGNRGFISVAGFSRFLKVCGSELVRLELS-C 384
           +KL D SL    +FLQ R   +  L    T N G ++VA      + C S L  L LS C
Sbjct: 86  SKLTDASLAKVLQFLQLRQLSLSLLP-ELTDN-GLVAVA------RGCPS-LEHLALSHC 136

Query: 385 SHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCSLKRLV 432
           S   ++   +  S   P LQ LNLSSC +L  Q  + I + C   R++
Sbjct: 137 SRLSDKGWAQAASSW-PRLQHLNLSSCSQLIEQTLDAIGQACRQLRVL 183


>gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens]
          Length = 223

 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 48/161 (29%), Positives = 69/161 (42%), Gaps = 31/161 (19%)

Query: 453 LQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDL 512
           LQ L L +C  + D  +   +   +  +LR L L     +T+NG+  +A GCP LE L L
Sbjct: 77  LQELDLTACSKLTDASLAKVL---QFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLAL 133

Query: 513 GWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILGTRMV 572
             C  L      + + A   P LQ L    N S C   I+         Q LD +G    
Sbjct: 134 SHCSRLSDKG--WAQAASSWPRLQHL----NLSSCSQLIE---------QTLDAIG---- 174

Query: 573 SPASLRKLLESCKDLSLLDVSFCSQIDNRAVLELNASFPKV 613
                    ++C+ L +LDV+ C  I+  AV    A  P+V
Sbjct: 175 ---------QACRQLRVLDVATCPGINMAAVRRFQAQLPQV 206



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 38/108 (35%), Positives = 52/108 (48%), Gaps = 15/108 (13%)

Query: 330 AKLDDTSL----EFLQSRCTLVQWLNLSWTGNRGFISVAGFSRFLKVCGSELVRLELS-C 384
           +KL D SL    +FLQ R   +  L    T N G ++VA      + C S L  L LS C
Sbjct: 86  SKLTDASLAKVLQFLQLRQLSLSLLP-ELTDN-GLVAVA------RGCPS-LEHLALSHC 136

Query: 385 SHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCSLKRLV 432
           S   ++   +  S   P LQ LNLSSC +L  Q  + I + C   R++
Sbjct: 137 SRLSDKGWAQAASSW-PRLQHLNLSSCSQLIEQTLDAIGQACRQLRVL 183


>gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo
           sapiens]
          Length = 410

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 83/320 (25%), Positives = 133/320 (41%), Gaps = 73/320 (22%)

Query: 280 FDKLPYELIQLILNHLTLPDLCRLAQTCK-----------------------------LL 310
           +D LP EL+  I + L LP+L +++  CK                             LL
Sbjct: 97  WDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLL 156

Query: 311 SQHCC-----------------DPLQYIHLNLQPYWAKLDDTSLEFLQSRCTLVQWLNLS 353
           SQ                     P +  H++L    + ++ ++L  + S+C+ +Q  NLS
Sbjct: 157 SQGVIAFRCPRSFMDQPLAEHFSPFRVQHMDLSN--SVIEVSTLHGILSQCSKLQ--NLS 212

Query: 354 WTGNRGFISVAGFSRFLKVCGSELVRLELS-CSHFLNETCLEVISEMCPNLQALNLSSC- 411
             G R  +S    +   K   S LVRL LS CS F +E  L+ +   C  L  LNLS C 
Sbjct: 213 LEGLR--LSDPIVNTLAK--NSNLVRLNLSGCSGF-SEFALQTLLSSCSRLDELNLSWCF 267

Query: 412 ---DKLPPQAFNHIAKLCSLKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYD 468
              +K    A  H+++  +   L  YR  ++++ L +++  C  L HL L   VM+++ D
Sbjct: 268 DFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKN-D 326

Query: 469 VIASMIGAKCKKLRTLDLWRCKN-ITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTR 527
                   +   L+ L L RC + I E  +    +G  +  + D+G CP         T 
Sbjct: 327 CFQEFF--QLNYLQHLSLSRCYDIIPETLLLVTRAGVRIRLDSDIG-CPQ--------TY 375

Query: 528 LAHQLPNLQKLFLTANRSVC 547
              +L +  KLF    R +C
Sbjct: 376 RTSKLKSSHKLFCQHVRVIC 395



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 47/172 (27%), Positives = 80/172 (46%), Gaps = 7/172 (4%)

Query: 428 LKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLW 487
           ++ + L  + +E + L  IL+ CS+LQ+LSL    +    D I + + AK   L  L+L 
Sbjct: 183 VQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLS---DPIVNTL-AKNSNLVRLNLS 238

Query: 488 RCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANR-SV 546
            C   +E  +  L S C  L+EL+L WC    +       +AH    + +L L+  R ++
Sbjct: 239 GCSGFSEFALQTLLSSCSRLDELNLSWCFDF-TEKHVQVAVAHVSETITQLNLSGYRKNL 297

Query: 547 CDTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQI 598
             +D+  L   C  L  LD+  + M+     ++  +    L  L +S C  I
Sbjct: 298 QKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQ-LNYLQHLSLSRCYDI 348



 Score = 30.4 bits (67), Expect = 5.1
 Identities = 24/73 (32%), Positives = 37/73 (50%), Gaps = 2/73 (2%)

Query: 531 QLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLL 590
           Q   LQ L L   R + D  ++ LA N + L +L++ G    S  +L+ LL SC  L  L
Sbjct: 204 QCSKLQNLSLEGLR-LSDPIVNTLAKN-SNLVRLNLSGCSGFSEFALQTLLSSCSRLDEL 261

Query: 591 DVSFCSQIDNRAV 603
           ++S+C     + V
Sbjct: 262 NLSWCFDFTEKHV 274


>gi|164663798 antagonist of mitotic exit network 1 homolog [Homo
           sapiens]
          Length = 258

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 55/222 (24%), Positives = 86/222 (38%), Gaps = 54/222 (24%)

Query: 396 ISEMC-PNLQALNLSSCDKLPPQAFNHIAKLCSLKRLVLYRTKVEQTALLSILNFCSELQ 454
           ISE+  P +Q L+L SCD +   A  H++    LK+L L  +K  + ++ S         
Sbjct: 55  ISEILHPEVQTLDLRSCD-ISDAALLHLSNCRKLKKLNLNASKGNRVSVTS--------- 104

Query: 455 HLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDLGW 514
                     E    +AS     C  L    L RC N+T+ G+  LA  C LL+ +DLG 
Sbjct: 105 ----------EGIKAVAS----SCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGG 150

Query: 515 CPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILGTRMVSP 574
           C                             S+ D  +  L  NC  LQ +D   T++   
Sbjct: 151 C----------------------------LSITDVSLHALGKNCPFLQCVDFSATQVSDS 182

Query: 575 ASLRKLLESC-KDLSLLDVSFCSQIDNRAVLELNASFPKVFI 615
             +  +   C K L  + +  C  + + AV  +    P++ I
Sbjct: 183 GVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRI 224



 Score = 29.6 bits (65), Expect = 8.6
 Identities = 30/124 (24%), Positives = 58/124 (46%), Gaps = 10/124 (8%)

Query: 492 ITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANR----SVC 547
           IT++ I+E+    P ++ LDL  C     S      L++    L+KL L A++    SV 
Sbjct: 50  ITDSNISEILH--PEVQTLDLRSCDI---SDAALLHLSN-CRKLKKLNLNASKGNRVSVT 103

Query: 548 DTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLELN 607
              I  +A +C+ L +  +     ++   +  L  +C+ L ++D+  C  I + ++  L 
Sbjct: 104 SEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALG 163

Query: 608 ASFP 611
            + P
Sbjct: 164 KNCP 167


>gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens]
          Length = 479

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 62/222 (27%), Positives = 96/222 (43%), Gaps = 12/222 (5%)

Query: 377 LVRLELS-CSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLC-SLKRLVLY 434
           +VRLELS C+ F   T   + S +   + +L++S C  +   A   I++L  +L  L L 
Sbjct: 220 VVRLELSGCNDF---TEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQ 276

Query: 435 RTKVEQTALLSILNFCSELQH-LSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNIT 493
              V  TAL           H L L SC  I ++ V+   +      L  L L  C  +T
Sbjct: 277 AYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVN--VVHSLPNLTALSLSGCSKVT 334

Query: 494 ENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDE 553
           ++G+  +A     L  LDL WCP +         +A  L  L++L L     + DT +  
Sbjct: 335 DDGVELVAENLRKLRSLDLSWCPRITDM--ALEYVACDLHRLEELVLDRCVRITDTGLSY 392

Query: 554 LACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFC 595
           L+   + L+ L +     V    L+ LL +   L LL  + C
Sbjct: 393 LS-TMSSLRSLYLRWCCQVQDFGLKHLL-ALGSLRLLSPAGC 432



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 42/212 (19%), Positives = 81/212 (38%), Gaps = 28/212 (13%)

Query: 420 NHIAKLCSLKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCK 479
           N+      +K + L R+ +    L  +L     +  L L  C    +  + +S+      
Sbjct: 187 NYALSKKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLSA---- 242

Query: 480 KLRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFT------------- 526
           ++ +L +  C N+ ++ IA ++   P L EL L       ++   FT             
Sbjct: 243 RITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLL 302

Query: 527 -----------RLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILGTRMVSPA 575
                       + H LPNL  L L+    V D  ++ +A N  +L+ LD+     ++  
Sbjct: 303 SCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDM 362

Query: 576 SLRKLLESCKDLSLLDVSFCSQIDNRAVLELN 607
           +L  +      L  L +  C +I +  +  L+
Sbjct: 363 ALEYVACDLHRLEELVLDRCVRITDTGLSYLS 394


>gi|157168349 F-box and leucine-rich repeat protein 19 [Homo
           sapiens]
          Length = 694

 Score = 40.4 bits (93), Expect = 0.005
 Identities = 30/93 (32%), Positives = 43/93 (46%), Gaps = 1/93 (1%)

Query: 331 KLDDTSLEFLQSRCTLVQWLNLSWTGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNE 390
           +L D SL  L      +  L+LS   + G  SV   +         LV L L+  H L +
Sbjct: 583 ELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTD 642

Query: 391 TCLEVISEMCPNLQALNLSSCDKLPPQAFNHIA 423
            CL +    CP L+ L+L SC +L P+A   +A
Sbjct: 643 HCLPLFRR-CPRLRRLDLRSCRQLSPEACARLA 674



 Score = 33.1 bits (74), Expect = 0.78
 Identities = 53/224 (23%), Positives = 87/224 (38%), Gaps = 27/224 (12%)

Query: 406 LNLSSCDKLPPQAFNHIAKLCSLKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIE 465
           ++LS    L P   + + +    + L L  T V +  L+ +LN    LQ L L  C  + 
Sbjct: 464 MDLSRRKSLTPPMLSGVVRR-QPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLS 522

Query: 466 DYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLE--------------ELD 511
               ++++  A    LR LDL   +++ ++ + EL    P  +              EL 
Sbjct: 523 ----VSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELR 578

Query: 512 LGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQ----LDIL 567
           L       +S     R A   P L  L L+    V D  +  L    + L++    L++ 
Sbjct: 579 LAGLELTDASLRLLLRHA---PQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLA 635

Query: 568 GTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLELNASFP 611
           G   ++   L  L   C  L  LD+  C Q+   A   L A+ P
Sbjct: 636 GCHRLTDHCL-PLFRRCPRLRRLDLRSCRQLSPEACARLAAAGP 678


>gi|16306574 F-box and leucine-rich repeat protein 5 isoform 2 [Homo
           sapiens]
          Length = 565

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 32/104 (30%), Positives = 50/104 (48%), Gaps = 5/104 (4%)

Query: 427 SLKRLVL-YRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLD 485
           S+K LVL Y + V    +  IL  C  L+HL L    + +      S +G  C+ LR LD
Sbjct: 205 SVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGC-CQSLRHLD 263

Query: 486 LWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLA 529
           L  C+ IT+  + +++    +L     G+   L++ST   T  A
Sbjct: 264 LSGCEKITDVALEKISRALGILTSHQSGF---LKTSTSKITSTA 304



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 26/97 (26%), Positives = 39/97 (40%), Gaps = 23/97 (23%)

Query: 370 LKVCGSELVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCSLK 429
           L   G+ +  L L+ S  ++   +  I E+CPNL+ L+L+  D +   AF+         
Sbjct: 199 LPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTD-ISDSAFDS-------- 249

Query: 430 RLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIED 466
                          S L  C  L+HL L  C  I D
Sbjct: 250 --------------WSWLGCCQSLRHLDLSGCEKITD 272


>gi|16306572 F-box and leucine-rich repeat protein 5 isoform 1 [Homo
           sapiens]
          Length = 691

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 32/104 (30%), Positives = 50/104 (48%), Gaps = 5/104 (4%)

Query: 427 SLKRLVL-YRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLD 485
           S+K LVL Y + V    +  IL  C  L+HL L    + +      S +G  C+ LR LD
Sbjct: 331 SVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGC-CQSLRHLD 389

Query: 486 LWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLA 529
           L  C+ IT+  + +++    +L     G+   L++ST   T  A
Sbjct: 390 LSGCEKITDVALEKISRALGILTSHQSGF---LKTSTSKITSTA 430



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 26/97 (26%), Positives = 39/97 (40%), Gaps = 23/97 (23%)

Query: 370 LKVCGSELVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCSLK 429
           L   G+ +  L L+ S  ++   +  I E+CPNL+ L+L+  D +   AF+         
Sbjct: 325 LPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTD-ISDSAFDS-------- 375

Query: 430 RLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIED 466
                          S L  C  L+HL L  C  I D
Sbjct: 376 --------------WSWLGCCQSLRHLDLSGCEKITD 398


>gi|30089926 F-box only protein 11 isoform 1 [Homo sapiens]
          Length = 843

 Score = 39.3 bits (90), Expect = 0.011
 Identities = 28/104 (26%), Positives = 50/104 (48%), Gaps = 3/104 (2%)

Query: 228 VKDKPVLSLKTSLIDMNDIEDDAYAEKDGCGMDSLNKKFS--SAVLGEGPNNGYF-DKLP 284
           ++ K +L  +T+    N +E  + +  +  G  +   + S  S  L   P   Y  +KLP
Sbjct: 17  LRRKTLLPKRTACPTKNSMEGASTSTTENFGHRAKRARVSGKSQDLSAAPAEQYLQEKLP 76

Query: 285 YELIQLILNHLTLPDLCRLAQTCKLLSQHCCDPLQYIHLNLQPY 328
            E++  I ++L   DLCR A  CK  S+   DP+ +  L ++ +
Sbjct: 77  DEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVF 120


>gi|30089924 F-box only protein 11 isoform 2 [Homo sapiens]
          Length = 686

 Score = 39.3 bits (90), Expect = 0.011
 Identities = 28/104 (26%), Positives = 50/104 (48%), Gaps = 3/104 (2%)

Query: 228 VKDKPVLSLKTSLIDMNDIEDDAYAEKDGCGMDSLNKKFS--SAVLGEGPNNGYF-DKLP 284
           ++ K +L  +T+    N +E  + +  +  G  +   + S  S  L   P   Y  +KLP
Sbjct: 17  LRRKTLLPKRTACPTKNSMEGASTSTTENFGHRAKRARVSGKSQDLSAAPAEQYLQEKLP 76

Query: 285 YELIQLILNHLTLPDLCRLAQTCKLLSQHCCDPLQYIHLNLQPY 328
            E++  I ++L   DLCR A  CK  S+   DP+ +  L ++ +
Sbjct: 77  DEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVF 120


>gi|30089922 F-box only protein 11 isoform 3 [Homo sapiens]
          Length = 585

 Score = 39.3 bits (90), Expect = 0.011
 Identities = 28/104 (26%), Positives = 50/104 (48%), Gaps = 3/104 (2%)

Query: 228 VKDKPVLSLKTSLIDMNDIEDDAYAEKDGCGMDSLNKKFS--SAVLGEGPNNGYF-DKLP 284
           ++ K +L  +T+    N +E  + +  +  G  +   + S  S  L   P   Y  +KLP
Sbjct: 17  LRRKTLLPKRTACPTKNSMEGASTSTTENFGHRAKRARVSGKSQDLSAAPAEQYLQEKLP 76

Query: 285 YELIQLILNHLTLPDLCRLAQTCKLLSQHCCDPLQYIHLNLQPY 328
            E++  I ++L   DLCR A  CK  S+   DP+ +  L ++ +
Sbjct: 77  DEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVF 120


>gi|8922303 ATP5S-like [Homo sapiens]
          Length = 257

 Score = 38.1 bits (87), Expect = 0.024
 Identities = 29/118 (24%), Positives = 60/118 (50%), Gaps = 15/118 (12%)

Query: 448 NFCS-ELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPL 506
           NFC   ++ +  G C +  +Y+ + +++  + K+L++L L RC ++ +  ++ L      
Sbjct: 120 NFCEVPVEAVDAGDCDI--NYEGLDNLL--RLKELQSLSLQRCSHVDDWCLSRLYPLADS 175

Query: 507 LEELDLGWCPTL-QSSTGCFTRLAHQLPNLQKLFLT-----ANRSVCDTDIDELACNC 558
           L+EL L  CP + +    C     H L NL++L ++     +N  +    ++E+  NC
Sbjct: 176 LQELSLAGCPRISERGLACL----HHLQNLRRLDISDLPAVSNPGLTQILVEEMLPNC 229



 Score = 30.4 bits (67), Expect = 5.1
 Identities = 21/72 (29%), Positives = 38/72 (52%), Gaps = 4/72 (5%)

Query: 361 ISVAGFSRFLKVCGSELVRLELS-CSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAF 419
           I+  G    L++   EL  L L  CSH +++ CL  +  +  +LQ L+L+ C ++  +  
Sbjct: 136 INYEGLDNLLRL--KELQSLSLQRCSH-VDDWCLSRLYPLADSLQELSLAGCPRISERGL 192

Query: 420 NHIAKLCSLKRL 431
             +  L +L+RL
Sbjct: 193 ACLHHLQNLRRL 204


>gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [Homo
            sapiens]
          Length = 1336

 Score = 37.0 bits (84), Expect = 0.054
 Identities = 51/271 (18%), Positives = 105/271 (38%), Gaps = 35/271 (12%)

Query: 286  ELIQLILNHLTLPDLCRLAQTCKLLSQHCCDPLQYIHLNLQPYWAKLDDTSLEFLQSRCT 345
            E+   + ++L+  DLC   + C+  ++ CCD   +  ++L  +   +    L  +  R  
Sbjct: 1068 EVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLN-HCKSITPLMLSGIIRRQP 1126

Query: 346  L---VQWLNLSWTGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNETCLEVISEMCPN 402
            +   + W N+S       I+     R L + G   + +   C            S  CP 
Sbjct: 1127 VSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALC------------SSSCPL 1174

Query: 403  LQALNLSSCDKLP---------------PQAFNHIAKLCSLKRLVLYRTKVEQTALLSIL 447
            L+ L++   + L                P   ++ +KL ++  L L    +   +L  I+
Sbjct: 1175 LRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLII 1234

Query: 448  NFCSELQHLSLGSCVMIEDYDV-IASMIGAKCK-KLRTLDLWRCKNITENGIAELASGCP 505
                 L  L L  C  + D  + + + +G   +  L  ++L  C  +T+  ++     C 
Sbjct: 1235 RHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLS-FFKRCG 1293

Query: 506  LLEELDLGWCPTLQSSTGCFTRLAHQLPNLQ 536
             +  +DL +C  + +  GC   +A    ++Q
Sbjct: 1294 NICHIDLRYCKQV-TKEGCEQFIAEMSVSVQ 1323



 Score = 33.5 bits (75), Expect = 0.60
 Identities = 43/172 (25%), Positives = 68/172 (39%), Gaps = 27/172 (15%)

Query: 447  LNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKL----------RTLDLWRCKNITENG 496
            LN C  +  L L   +  +   +  S      K+L          R L L  C  I  + 
Sbjct: 1107 LNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSA 1166

Query: 497  IAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELAC 556
            +   +S CPLL  LD+ W   L+ +     R     P   +     NRS     ++    
Sbjct: 1167 LC--SSSCPLLRTLDVQWVEGLKDAQ---MRDLLSPPTDNRPGQMDNRSKLRNIVE---- 1217

Query: 557  NCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLELNA 608
               RL  LDI      + ASLR ++     LS L +S+C+ + ++++  L A
Sbjct: 1218 --LRLAGLDI------TDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTA 1261


>gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [Homo
            sapiens]
          Length = 1265

 Score = 36.2 bits (82), Expect = 0.092
 Identities = 49/259 (18%), Positives = 100/259 (38%), Gaps = 35/259 (13%)

Query: 286  ELIQLILNHLTLPDLCRLAQTCKLLSQHCCDPLQYIHLNLQPYWAKLDDTSLEFLQSRCT 345
            E+   + ++L+  DLC   + C+  ++ CCD   +  ++L  +   +    L  +  R  
Sbjct: 999  EVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLN-HCKSITPLMLSGIIRRQP 1057

Query: 346  L---VQWLNLSWTGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNETCLEVISEMCPN 402
            +   + W N+S       I+     R L + G   + +   C            S  CP 
Sbjct: 1058 VSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALC------------SSSCPL 1105

Query: 403  LQALNLSSCDKLP---------------PQAFNHIAKLCSLKRLVLYRTKVEQTALLSIL 447
            L+ L++   + L                P   ++ +KL ++  L L    +   +L  I+
Sbjct: 1106 LRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLII 1165

Query: 448  NFCSELQHLSLGSCVMIEDYDV-IASMIGAKCK-KLRTLDLWRCKNITENGIAELASGCP 505
                 L  L L  C  + D  + + + +G   +  L  ++L  C  +T+  ++     C 
Sbjct: 1166 RHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLS-FFKRCG 1224

Query: 506  LLEELDLGWCPTLQSSTGC 524
             +  +DL +C  + +  GC
Sbjct: 1225 NICHIDLRYCKQV-TKEGC 1242



 Score = 33.5 bits (75), Expect = 0.60
 Identities = 43/172 (25%), Positives = 68/172 (39%), Gaps = 27/172 (15%)

Query: 447  LNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKL----------RTLDLWRCKNITENG 496
            LN C  +  L L   +  +   +  S      K+L          R L L  C  I  + 
Sbjct: 1038 LNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSA 1097

Query: 497  IAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELAC 556
            +   +S CPLL  LD+ W   L+ +     R     P   +     NRS     ++    
Sbjct: 1098 LC--SSSCPLLRTLDVQWVEGLKDAQ---MRDLLSPPTDNRPGQMDNRSKLRNIVE---- 1148

Query: 557  NCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLELNA 608
               RL  LDI      + ASLR ++     LS L +S+C+ + ++++  L A
Sbjct: 1149 --LRLAGLDI------TDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTA 1192


>gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens]
          Length = 1162

 Score = 35.8 bits (81), Expect = 0.12
 Identities = 48/210 (22%), Positives = 88/210 (41%), Gaps = 19/210 (9%)

Query: 406  LNLSSCDKLPPQAFNHIAKLCSLKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIE 465
            ++LS C  + PQA + I K   +  L L  T + +  L  ++N    L+ L L  C    
Sbjct: 933  IDLSRCKAIVPQALSGIIKRQPVS-LDLSWTNISKKQLTWLVNRLPGLKDLLLAGC---- 987

Query: 466  DYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELAS---------GCPLLEELDLGWCP 516
             +  ++++  + C  LRTLDL     I +  I +L +             L  +      
Sbjct: 988  SWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLA 1047

Query: 517  TLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELAC--NCTR--LQQLDILGTRMV 572
             L  +      +   +P L +L L+    + D   + L    + TR  L +L++ G   +
Sbjct: 1048 GLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKL 1107

Query: 573  SPASLRKLLESCKDLSLLDVSFCSQIDNRA 602
            +  +L   L    +++L+D+  C QI  +A
Sbjct: 1108 TDQTL-IYLRRIANVTLIDLRGCKQITRKA 1136


>gi|5453880 acidic (leucine-rich) nuclear phosphoprotein 32 family,
           member A [Homo sapiens]
          Length = 249

 Score = 35.8 bits (81), Expect = 0.12
 Identities = 30/84 (35%), Positives = 40/84 (47%), Gaps = 7/84 (8%)

Query: 355 TGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKL 414
           T N G  S+A   +  K     L +LELS +       LEV++E CPNL  LNLS     
Sbjct: 49  TINVGLTSIANLPKLNK-----LKKLELSDNRVSGG--LEVLAEKCPNLTHLNLSGNKIK 101

Query: 415 PPQAFNHIAKLCSLKRLVLYRTKV 438
                  + KL +LK L L+  +V
Sbjct: 102 DLSTIEPLKKLENLKSLDLFNCEV 125


>gi|222136647 F-box protein 47 [Homo sapiens]
          Length = 452

 Score = 35.0 bits (79), Expect = 0.21
 Identities = 15/36 (41%), Positives = 23/36 (63%)

Query: 278 GYFDKLPYELIQLILNHLTLPDLCRLAQTCKLLSQH 313
           G F  LP E+ Q+IL +L++ D+  L+   K +SQH
Sbjct: 42  GNFKALPLEIFQIILKYLSVKDISMLSMVSKTVSQH 77


>gi|113205085 leucine rich repeat containing 31 [Homo sapiens]
          Length = 552

 Score = 34.7 bits (78), Expect = 0.27
 Identities = 49/201 (24%), Positives = 78/201 (38%), Gaps = 12/201 (5%)

Query: 376 ELVRLELSCSHFLNETCLEVISE--MCPNLQALNLSSCDKLPPQAFNH---IAKLCSLKR 430
           EL +L+LSC+  L     +  ++  M  +LQ L+L  C        +    I  L +L+ 
Sbjct: 283 ELRKLDLSCNKDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQE 342

Query: 431 LVLYRTKVEQTA---LLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDL- 486
           L L   K   ++   LLS L F   L+ L + +C +  +     +        L   +L 
Sbjct: 343 LDLSANKKMGSSSENLLSRLRFLPALKSLVINNCALESETFTALAEASVHLSALEVFNLS 402

Query: 487 W-RCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAH--QLPNLQKLFLTAN 543
           W +C       + E       L+ L L  C  +         +     L  LQKL L+ N
Sbjct: 403 WNKCVGGNLKLLLETLKLSMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYN 462

Query: 544 RSVCDTDIDELACNCTRLQQL 564
            S+CD        N   L++L
Sbjct: 463 DSICDAGWTMFCQNVRFLKEL 483



 Score = 34.3 bits (77), Expect = 0.35
 Identities = 64/253 (25%), Positives = 102/253 (40%), Gaps = 39/253 (15%)

Query: 350 LNLSWTGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNE--TCLEVISEMCPNLQALN 407
           LNLSW    G        +F K  GS++  +EL      +E  T L  +  M  +L+ L+
Sbjct: 175 LNLSWNSKVGGNLPLILQKFQK--GSKIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLD 232

Query: 408 LSSCDKLPPQAFNHIAKLCSLKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIEDY 467
           LS  ++    + N IA+                      L   S L+ L L SC + +  
Sbjct: 233 LS-INRDIVGSLNSIAQG---------------------LKSTSNLKVLKLHSCGLSQKS 270

Query: 468 DVIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEEL---DLGWCPTLQSSTGC 524
             I         +LR LDL  C      G  +  +   +L+ L   DL  C         
Sbjct: 271 VKILDAAFRYLGELRKLDL-SCNKDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMS 329

Query: 525 FTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILGTRMVSPASLRK----- 579
            T++   L NLQ+L L+AN+ +  +  + L    +RL+ L  L + +++  +L       
Sbjct: 330 LTQVIPLLSNLQELDLSANKKMGSSSENLL----SRLRFLPALKSLVINNCALESETFTA 385

Query: 580 LLESCKDLSLLDV 592
           L E+   LS L+V
Sbjct: 386 LAEASVHLSALEV 398


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.135    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,784,390
Number of Sequences: 37866
Number of extensions: 1051911
Number of successful extensions: 2522
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 2238
Number of HSP's gapped (non-prelim): 136
length of query: 621
length of database: 18,247,518
effective HSP length: 108
effective length of query: 513
effective length of database: 14,157,990
effective search space: 7263048870
effective search space used: 7263048870
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.