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Search of human proteins with 161333854
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2
[Homo sapiens]
(690 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2 ... 1399 0.0
gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1 ... 1378 0.0
gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens] 161 2e-39
gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens] 160 3e-39
gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens] 121 2e-27
gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens] 112 1e-24
gi|254039600 F-box and leucine-rich repeat protein 17 [Homo sapi... 76 1e-13
gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens] 72 2e-12
gi|164663798 antagonist of mitotic exit network 1 homolog [Homo ... 71 3e-12
gi|16306588 F-box and leucine-rich repeat protein 4 [Homo sapiens] 70 7e-12
gi|190194416 F-box and leucine-rich repeat protein 15 [Homo sapi... 60 9e-09
gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [... 59 2e-08
gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [... 58 3e-08
gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo ... 55 2e-07
gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens] 54 4e-07
gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens] 54 4e-07
gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens] 54 5e-07
gi|16306576 F-box and leucine-rich repeat protein 6 isoform 1 [H... 52 2e-06
gi|157168349 F-box and leucine-rich repeat protein 19 [Homo sapi... 52 2e-06
gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo ... 51 3e-06
gi|61742136 F-box and leucine-rich repeat protein 6 isoform 2 [H... 50 9e-06
gi|16306574 F-box and leucine-rich repeat protein 5 isoform 2 [H... 48 3e-05
gi|16306572 F-box and leucine-rich repeat protein 5 isoform 1 [H... 48 3e-05
gi|16506299 leucine rich repeat containing 42 [Homo sapiens] 44 5e-04
gi|148922963 F-box and leucine-rich repeat protein 21 [Homo sapi... 41 0.003
gi|8923179 F-box and leucine-rich repeat protein 12 [Homo sapiens] 40 0.006
gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 fami... 40 0.009
gi|210147571 acidic (leucine-rich) nuclear phosphoprotein 32 fam... 38 0.036
gi|33589814 zyg-11 homolog B (C. elegans)-like [Homo sapiens] 38 0.036
gi|16306584 F-box and leucine-rich repeat protein 3 [Homo sapiens] 37 0.047
>gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2
[Homo sapiens]
Length = 690
Score = 1399 bits (3622), Expect = 0.0
Identities = 690/690 (100%), Positives = 690/690 (100%)
Query: 1 MTPELMIKACSFYTGHLVKTHFCTWRDIARTNENVVLAEKMNRAVTCYNFRLQKSVFHHW 60
MTPELMIKACSFYTGHLVKTHFCTWRDIARTNENVVLAEKMNRAVTCYNFRLQKSVFHHW
Sbjct: 1 MTPELMIKACSFYTGHLVKTHFCTWRDIARTNENVVLAEKMNRAVTCYNFRLQKSVFHHW 60
Query: 61 HSYMEDQKEKLKNILLRIQQIIYCHKLTIILTKWRNTARHKSKKKEDELILKHELQLKKW 120
HSYMEDQKEKLKNILLRIQQIIYCHKLTIILTKWRNTARHKSKKKEDELILKHELQLKKW
Sbjct: 61 HSYMEDQKEKLKNILLRIQQIIYCHKLTIILTKWRNTARHKSKKKEDELILKHELQLKKW 120
Query: 121 KNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQ 180
KNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQ
Sbjct: 121 KNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQ 180
Query: 181 VNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRS 240
VNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRS
Sbjct: 181 VNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRS 240
Query: 241 VSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQN 300
VSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQN
Sbjct: 241 VSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQN 300
Query: 301 LSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDM 360
LSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDM
Sbjct: 301 LSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDM 360
Query: 361 PTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKF 420
PTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKF
Sbjct: 361 PTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKF 420
Query: 421 IDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMR 480
IDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMR
Sbjct: 421 IDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMR 480
Query: 481 IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGT 540
IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGT
Sbjct: 481 IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGT 540
Query: 541 DISNEGLNVLSRHKKLKELSVSECYRITDDGIQITDSAMEMLSAKCHYLHILDISGCVLL 600
DISNEGLNVLSRHKKLKELSVSECYRITDDGIQITDSAMEMLSAKCHYLHILDISGCVLL
Sbjct: 541 DISNEGLNVLSRHKKLKELSVSECYRITDDGIQITDSAMEMLSAKCHYLHILDISGCVLL 600
Query: 601 TDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSSKVQQQEYNTNDPPRWFGYDREGNP 660
TDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSSKVQQQEYNTNDPPRWFGYDREGNP
Sbjct: 601 TDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSSKVQQQEYNTNDPPRWFGYDREGNP 660
Query: 661 VTELDNITSSKGALELTVKKSTYSSEDQAA 690
VTELDNITSSKGALELTVKKSTYSSEDQAA
Sbjct: 661 VTELDNITSSKGALELTVKKSTYSSEDQAA 690
>gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1
[Homo sapiens]
Length = 735
Score = 1378 bits (3566), Expect = 0.0
Identities = 690/735 (93%), Positives = 690/735 (93%), Gaps = 45/735 (6%)
Query: 1 MTPELMIKACSFYTGHLVKTHFCTWRDIARTNENVVLAEKMNRAVTCYNFRLQKSVFHHW 60
MTPELMIKACSFYTGHLVKTHFCTWRDIARTNENVVLAEKMNRAVTCYNFRLQKSVFHHW
Sbjct: 1 MTPELMIKACSFYTGHLVKTHFCTWRDIARTNENVVLAEKMNRAVTCYNFRLQKSVFHHW 60
Query: 61 HSYMEDQKEKLKNILLRIQQIIYCHKLTIILTKWRNTARHKSKKKEDELILKHELQLKKW 120
HSYMEDQKEKLKNILLRIQQIIYCHKLTIILTKWRNTARHKSKKKEDELILKHELQLKKW
Sbjct: 61 HSYMEDQKEKLKNILLRIQQIIYCHKLTIILTKWRNTARHKSKKKEDELILKHELQLKKW 120
Query: 121 KNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQ 180
KNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQ
Sbjct: 121 KNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQ 180
Query: 181 VNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRS 240
VNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRS
Sbjct: 181 VNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRS 240
Query: 241 VSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQN 300
VSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQN
Sbjct: 241 VSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQN 300
Query: 301 LSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDM 360
LSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDM
Sbjct: 301 LSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDM 360
Query: 361 PTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKF 420
PTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKF
Sbjct: 361 PTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKF 420
Query: 421 IDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMR 480
IDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMR
Sbjct: 421 IDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMR 480
Query: 481 IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGT 540
IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGT
Sbjct: 481 IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGT 540
Query: 541 DISNEGLNVLSRHKKLKELSVSECYRITDDGIQ--------------------------- 573
DISNEGLNVLSRHKKLKELSVSECYRITDDGIQ
Sbjct: 541 DISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKA 600
Query: 574 ------------------ITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQL 615
ITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQL
Sbjct: 601 LAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQL 660
Query: 616 RILKMQYCTNISKKAAQRMSSKVQQQEYNTNDPPRWFGYDREGNPVTELDNITSSKGALE 675
RILKMQYCTNISKKAAQRMSSKVQQQEYNTNDPPRWFGYDREGNPVTELDNITSSKGALE
Sbjct: 661 RILKMQYCTNISKKAAQRMSSKVQQQEYNTNDPPRWFGYDREGNPVTELDNITSSKGALE 720
Query: 676 LTVKKSTYSSEDQAA 690
LTVKKSTYSSEDQAA
Sbjct: 721 LTVKKSTYSSEDQAA 735
>gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens]
Length = 423
Score = 161 bits (408), Expect = 2e-39
Identities = 107/375 (28%), Positives = 193/375 (51%), Gaps = 14/375 (3%)
Query: 158 LPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQ 217
LP+ +L+IF +L + + C Q++ AW ++ S W ID + + + + + + +
Sbjct: 15 LPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFNFQIDVEGRVVENISK 74
Query: 218 RWRLNVLRLNFRGCL----LRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCPGV 273
R + +L+ RGC+ KTF +CRN++ LN++ C TD + +S C +
Sbjct: 75 RCGGFLRKLSLRGCIGVGDSSLKTF--AQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKL 132
Query: 274 LCLNLSN-TTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLS 332
L+L++ +ITN +++ + NL+ L+L++C + T G++ L GC L L L
Sbjct: 133 KHLDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALV--RGCRGLKALLLR 190
Query: 333 GCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDC 392
GCTQ+ + ++I N C ++ L + +TD V + C R+ +L +G +++D
Sbjct: 191 GCTQLEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQICRGCHRLQALCLSGCSNLTDA 250
Query: 393 TFRA--LSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS-P 449
+ A L+ +L+ + +TDA F + +N L + + +C ITDS+L LS
Sbjct: 251 SLTALGLNCPRLQILEAARCSHLTDAGFTLLARNCHELEKMDLEECILITDSTLIQLSIH 310
Query: 450 LKQLTVLNLANCVRIGDMGLKQFLDGPAS-MRIRELNLSNCVRLSDASVMKLSERCPNLN 508
+L L+L++C I D G+ + R+R L L NC+ ++D ++ L E C L
Sbjct: 311 CPKLQALSLSHCELITDDGILHLSNSTCGHERLRVLELDNCLLITDVALEHL-ENCRGLE 369
Query: 509 YLSLRNCEHLTAQGI 523
L L +C+ +T GI
Sbjct: 370 RLELYDCQQVTRAGI 384
Score = 127 bits (320), Expect = 3e-29
Identities = 93/318 (29%), Positives = 154/318 (48%), Gaps = 17/318 (5%)
Query: 329 LDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPH 388
L L GC + + A +C I HL +N +TD+ +L CS++ L T
Sbjct: 83 LSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHLDLTSCVS 142
Query: 389 ISDCTFRALS-ACK-LRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRS 446
I++ + + +S C+ L + ++T + + + L + + C + D +L+
Sbjct: 143 ITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALVRGCRGLKALLLRGCTQLEDEALKH 202
Query: 447 LSPL-KQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCP 505
+ +L LNL +C RI D G+ Q G R++ L LS C L+DAS+ L CP
Sbjct: 203 IQNYCHELVSLNLQSCSRITDEGVVQICRG--CHRLQALCLSGCSNLTDASLTALGLNCP 260
Query: 506 NLNYLSLRNCEHLTAQGIGYIV-NIFSLVSIDLSGTD-ISNEGLNVLSRH-KKLKELSVS 562
L L C HLT G + N L +DL I++ L LS H KL+ LS+S
Sbjct: 261 RLQILEAARCSHLTDAGFTLLARNCHELEKMDLEECILITDSTLIQLSIHCPKLQALSLS 320
Query: 563 ECYRITDDGIQITDSAMEMLSAKCHY--LHILDISGCVLLTDQILEDLQIGCKQLRILKM 620
C ITDDGI + + ++ C + L +L++ C+L+TD LE L+ C+ L L++
Sbjct: 321 HCELITDDGI------LHLSNSTCGHERLRVLELDNCLLITDVALEHLE-NCRGLERLEL 373
Query: 621 QYCTNISKKAAQRMSSKV 638
C +++ +RM +++
Sbjct: 374 YDCQQVTRAGIKRMRAQL 391
Score = 105 bits (261), Expect = 2e-22
Identities = 78/258 (30%), Positives = 126/258 (48%), Gaps = 25/258 (9%)
Query: 402 LRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPL-KQLTVLNLAN 460
LRK+ G V D+S K +N N+ H+ + C ITDS+ SLS +L L+L +
Sbjct: 80 LRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHLDLTS 139
Query: 461 CVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTA 520
CV I + LK +G ++ LNLS C +++ + L C L L LR C L
Sbjct: 140 CVSITNSSLKGISEGCRNLEY--LNLSWCDQITKDGIEALVRGCRGLKALLLRGCTQLED 197
Query: 521 QGIGYIVNI-FSLVSIDL-SGTDISNEGLNVLSRH-KKLKELSVSECYRITDDGI----- 572
+ + +I N LVS++L S + I++EG+ + R +L+ L +S C +TD +
Sbjct: 198 EALKHIQNYCHELVSLNLQSCSRITDEGVVQICRGCHRLQALCLSGCSNLTDASLTALGL 257
Query: 573 --------------QITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRIL 618
+TD+ +L+ CH L +D+ C+L+TD L L I C +L+ L
Sbjct: 258 NCPRLQILEAARCSHLTDAGFTLLARNCHELEKMDLEECILITDSTLIQLSIHCPKLQAL 317
Query: 619 KMQYCTNISKKAAQRMSS 636
+ +C I+ +S+
Sbjct: 318 SLSHCELITDDGILHLSN 335
Score = 44.3 bits (103), Expect = 4e-04
Identities = 30/113 (26%), Positives = 54/113 (47%), Gaps = 11/113 (9%)
Query: 535 IDLSGTDISNEGLNVLSRHKK----LKELSVSECYRITDDGIQITDSAMEMLSAKCHYLH 590
IDL I EG V + K+ L++LS+ C I + DS+++ + C +
Sbjct: 55 IDLFNFQIDVEGRVVENISKRCGGFLRKLSLRGC-------IGVGDSSLKTFAQNCRNIE 107
Query: 591 ILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSSKVQQQEY 643
L+++GC +TD L C +L+ L + C +I+ + + +S + EY
Sbjct: 108 HLNLNGCTKITDSTCYSLSRFCSKLKHLDLTSCVSITNSSLKGISEGCRNLEY 160
>gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens]
Length = 436
Score = 160 bits (406), Expect = 3e-39
Identities = 109/373 (29%), Positives = 196/373 (52%), Gaps = 10/373 (2%)
Query: 158 LPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQ 217
LP+ +L+IF +L + + C QV+ AW ++ S W ID + I + + + +
Sbjct: 28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISK 87
Query: 218 RWRLNVLRLNFRGCL-LRPKTFRSVS-HCRNLQELNVSDCPTFTDESMRHISEGCPGVLC 275
R + +L+ RGCL + R+ + +CRN++ LN++ C TD + +S+ C +
Sbjct: 88 RCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRH 147
Query: 276 LNLSN-TTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGC 334
L+L++ T+ITN +++ L L+ L++++C + T G+Q L GC L L L GC
Sbjct: 148 LDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALV--RGCGGLKALFLKGC 205
Query: 335 TQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTF 394
TQ+ + +YI C ++ L + +TD + + C ++ SL +G +I+D
Sbjct: 206 TQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAIL 265
Query: 395 RAL--SACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS-PLK 451
AL + +LR + ++TD F + +N L + + +C ITDS+L LS
Sbjct: 266 NALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCP 325
Query: 452 QLTVLNLANCVRIGDMGLKQFLDGP-ASMRIRELNLSNCVRLSDASVMKLSERCPNLNYL 510
+L VL+L++C I D G++ +G A ++ + L NC ++DAS+ L + C +L +
Sbjct: 326 RLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHL-KSCHSLERI 384
Query: 511 SLRNCEHLTAQGI 523
L +C+ +T GI
Sbjct: 385 ELYDCQQITRAGI 397
Score = 99.4 bits (246), Expect = 1e-20
Identities = 81/299 (27%), Positives = 139/299 (46%), Gaps = 42/299 (14%)
Query: 345 IANSCTGIMH-LTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLR 403
I+ C G + L++ + DN ++ + C I L G +D T +LS
Sbjct: 85 ISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLS----- 139
Query: 404 KIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS---PLKQLTVLNLAN 460
KF K L H+ +A C IT+ SL++LS PL L LN++
Sbjct: 140 ---------------KFCSK----LRHLDLASCTSITNMSLKALSEGCPL--LEQLNISW 178
Query: 461 CVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTA 520
C ++ G++ + G ++ L L C +L D ++ + CP L L+L+ C +T
Sbjct: 179 CDQVTKDGIQALVRGCGGLKA--LFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITD 236
Query: 521 QGIGYIVN-IFSLVSIDLSG-TDISNEGLNVLSRH-KKLKELSVSECYRITDDGIQITDS 577
+G+ I L S+ SG ++I++ LN L ++ +L+ L V+ C ++TD G
Sbjct: 237 EGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTT--- 293
Query: 578 AMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSS 636
L+ CH L +D+ CV +TD L L I C +L++L + +C I+ + + +
Sbjct: 294 ----LARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGN 348
>gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens]
Length = 491
Score = 121 bits (304), Expect = 2e-27
Identities = 103/419 (24%), Positives = 179/419 (42%), Gaps = 65/419 (15%)
Query: 152 KCDISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKY 211
+ I LP+ +++QIF +L + C +V W + LW I + + + D+
Sbjct: 111 QASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTG-ETINVDRA 169
Query: 212 IVSTLQRWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCP 271
+ L R C P C L+ + VS C TD + I++ CP
Sbjct: 170 LKV-----------LTRRLCQDTPNV------CLMLETVTVSGCRRLTDRGLYTIAQCCP 212
Query: 272 GVL------CLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFT------DKGLQYLNL 319
+ C N+SN + + + L P NL++L ++ C + T + ++ L
Sbjct: 213 ELRRLEVSGCYNISNEAVFD-VVSLCP----NLEHLDVSGCSKVTCISLTREASIKLSPL 267
Query: 320 GNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRIT 379
+ YLD++ C + +G IA CT + HL + LTD ++ LV C+ I
Sbjct: 268 HGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIK 327
Query: 380 SLVFTGAPHISDCTFRALS--ACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCK 437
L + +SD R ++ +LR + RVTD +++ K L ++ C+
Sbjct: 328 ELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCE 387
Query: 438 GITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASV 497
GITD + L+ NC +++ L++ C +SD +
Sbjct: 388 GITDHGVEYLA----------KNCT-----------------KLKSLDIGKCPLVSDTGL 420
Query: 498 MKLSERCPNLNYLSLRNCEHLTAQGIGYI-VNIFSLVSIDLSGTDISNEGLNVLSRHKK 555
L+ C NL LSL++CE +T QG+ + N F L ++++ ++S E L + RH K
Sbjct: 421 ECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCK 479
Score = 111 bits (278), Expect = 2e-24
Identities = 87/322 (27%), Positives = 153/322 (47%), Gaps = 37/322 (11%)
Query: 283 ITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGF 342
+T R + P L+ ++++ CRR TD+GL + C +L L++SGC IS +
Sbjct: 173 LTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLY--TIAQCCPELRRLEVSGCYNISNEAV 230
Query: 343 RYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKL 402
+ + C + HL ++ +T C+ E +++ L H + R L
Sbjct: 231 FDVVSLCPNLEHLDVSGCSKVT--CISLTREASIKLSPL------HGKQISIRYLDMTDC 282
Query: 403 RKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSL----SPLKQLTVLNL 458
+ EG I + L+H+Y+ C +TD LR L + +K+L+V
Sbjct: 283 FVLEDEG--------LHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSV--- 331
Query: 459 ANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHL 518
++C + D GL++ R+R L++++C R++D + +++ C L YL+ R CE +
Sbjct: 332 SDCRFVSDFGLREI--AKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGI 389
Query: 519 TAQGIGYIV-NIFSLVSIDLSGTD-ISNEGLNVLSRH-KKLKELSVSECYRITDDGIQIT 575
T G+ Y+ N L S+D+ +S+ GL L+ + LK LS+ C IT G+QI
Sbjct: 390 TDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQI- 448
Query: 576 DSAMEMLSAKCHYLHILDISGC 597
++A C L L++ C
Sbjct: 449 ------VAANCFDLQTLNVQDC 464
Score = 100 bits (248), Expect = 6e-21
Identities = 83/313 (26%), Positives = 143/313 (45%), Gaps = 49/313 (15%)
Query: 321 NGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITS 380
N C L + +SGC +++ +G IA C + L ++ +++ V +V C +
Sbjct: 183 NVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEH 242
Query: 381 LVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGIT 440
L +G ++ + ++ KL + K++ S +++D M DC +
Sbjct: 243 LDVSGCSKVTCISLTREASIKLSPLH---GKQI---SIRYLD----------MTDCFVLE 286
Query: 441 DSSLRSLSP-LKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMK 499
D L +++ QLT L L CVR+ D GL+ + AS I+EL++S+C +SD + +
Sbjct: 287 DEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCAS--IKELSVSDCRFVSDFGLRE 344
Query: 500 LSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKEL 559
+++ L YLS+ +C +T GI Y+ S KL+ L
Sbjct: 345 IAKLESRLRYLSIAHCGRVTDVGIRYVAKYCS-----------------------KLRYL 381
Query: 560 SVSECYRITDDGIQITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILK 619
+ C ITD G+ E L+ C L LDI C L++D LE L + C L+ L
Sbjct: 382 NARGCEGITDHGV-------EYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLS 434
Query: 620 MQYCTNISKKAAQ 632
++ C +I+ + Q
Sbjct: 435 LKSCESITGQGLQ 447
Score = 35.4 bits (80), Expect = 0.18
Identities = 29/113 (25%), Positives = 55/113 (48%), Gaps = 17/113 (15%)
Query: 534 SIDLSGTDIS-NEGLNVLSRHK---------KLKELSVSECYRITDDGIQITDSAMEMLS 583
+I L+G I+ + L VL+R L+ ++VS C R+TD G+ ++
Sbjct: 156 TIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYT-------IA 208
Query: 584 AKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSS 636
C L L++SGC ++++ + D+ C L L + C+ ++ + R +S
Sbjct: 209 QCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREAS 261
>gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens]
Length = 418
Score = 112 bits (280), Expect = 1e-24
Identities = 118/491 (24%), Positives = 198/491 (40%), Gaps = 102/491 (20%)
Query: 151 LKCDISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDK 210
++ IS L + IF YL ++D QV AW S+W ++
Sbjct: 1 METHISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPS 60
Query: 211 YIVSTLQRWRLNVLRLNFRGCLLRPKTFRSVSHC----RNLQELNVSDCPTFTDESMRHI 266
S R V L+ R RS+S+ N++ LN+S C TD + H
Sbjct: 61 LFPSLQARGIRRVQILSLR---------RSLSYVIQGMANIESLNLSGCYNLTDNGLGHA 111
Query: 267 SEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGL----QYLNLGNG 322
+ +L+ L+L+ C++ TD L QYL
Sbjct: 112 ------------------------FVQEIGSLRALNLSLCKQITDSSLGRIAQYLK---- 143
Query: 323 CHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLV 382
L L+L GC+ I+ G IA + L + L+D
Sbjct: 144 --GLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSD----------------- 184
Query: 383 FTGAPHISDCTFRALSACK-LRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITD 441
G H++ T A C L ++ + +++TD S K I + L + ++ C GI+D
Sbjct: 185 -VGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISD 243
Query: 442 SSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLS 501
+ L LS + L LNL +C I D G+ G S+R+ L++S C ++ D S+ ++
Sbjct: 244 AGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMG--SLRLSGLDVSFCDKVGDQSLAYIA 301
Query: 502 ERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKK-LKELS 560
+ L LSL +C IS++G+N + R L+ L+
Sbjct: 302 QGLDGLKSLSLCSCH-------------------------ISDDGINRMVRQMHGLRTLN 336
Query: 561 VSECYRITDDGIQITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDL-QIGCKQLRILK 619
+ +C RITD G+++ + L+ +D+ GC +T + LE + Q+ C ++ L
Sbjct: 337 IGQCVRITDKGLELIAEHLSQLTG-------IDLYGCTRITKRGLERITQLPCLKVLNLG 389
Query: 620 MQYCTNISKKA 630
+ T+ K+A
Sbjct: 390 LWQMTDSEKEA 400
Score = 92.0 bits (227), Expect = 2e-18
Identities = 102/409 (24%), Positives = 171/409 (41%), Gaps = 66/409 (16%)
Query: 228 FRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRT 287
+R +R V +L+ N S P+ +R + +L L R+
Sbjct: 35 WRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGIRRVQ-----ILSLR--------RS 81
Query: 288 MRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIAN 347
+ + + N+++L+L+ C TD GL + + L L+LS C QI+ IA
Sbjct: 82 LSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQE-IGSLRALNLSLCKQITDSSLGRIAQ 140
Query: 348 SCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRF 407
G+ L + +T+ + + R+ SL H+SD L+ + +
Sbjct: 141 YLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAG--MTRSAA 198
Query: 408 EGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSP-LKQLTVLNLANCVRIGD 466
EG L + + DC+ +TD SL+ +S L L +LNL+ C I D
Sbjct: 199 EGCL---------------GLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISD 243
Query: 467 MGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYI 526
GL + +R LNL +C +SD +M L+ L+ L + C+ + Q + YI
Sbjct: 244 AGLLHLSHMGS---LRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYI 300
Query: 527 VNIFSLVSIDLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQITDSAMEMLSAKC 586
+GL+ LK LS+ C+ I+DDGI + +
Sbjct: 301 A-----------------QGLD------GLKSLSLCSCH-ISDDGIN-------RMVRQM 329
Query: 587 HYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMS 635
H L L+I CV +TD+ LE + QL + + CT I+K+ +R++
Sbjct: 330 HGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERIT 378
>gi|254039600 F-box and leucine-rich repeat protein 17 [Homo
sapiens]
Length = 303
Score = 75.9 bits (185), Expect = 1e-13
Identities = 72/281 (25%), Positives = 122/281 (43%), Gaps = 44/281 (15%)
Query: 270 CPGVL------CLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGC 323
CPG+L C LS+T+I + H LQ + + + TD+GL+ LG+ C
Sbjct: 13 CPGLLRYTAYRCKQLSDTSII-----AVASHCPLLQKVHVGNQDKLTDEGLK--QLGSKC 65
Query: 324 HKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVF 383
+L + C +IS +G IA C + + + + +TD VKA E C + + F
Sbjct: 66 RELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGF 125
Query: 384 TGAPHISD-----CTFRALSACKLRKIRFEGNKRV---------------------TDAS 417
G S R LS+ LR I N+ V D
Sbjct: 126 MGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRC 185
Query: 418 FKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQ-LTVLNLANCVRIGDMGLKQFLDGP 476
+ I K NL +Y+ CK ITD +L ++ + +++ C I D G L
Sbjct: 186 VEVIAKEGQNLKELYLVSCK-ITDYALIAIGRYSMTIETVDVGWCKEITDQGAT--LIAQ 242
Query: 477 ASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLS-LRNCE 516
+S +R L L C ++++ +V +L ++ P++ + + L++C+
Sbjct: 243 SSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCK 283
Score = 73.6 bits (179), Expect = 6e-13
Identities = 58/256 (22%), Positives = 119/256 (46%), Gaps = 27/256 (10%)
Query: 411 KRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSL-SPLKQLTVLNLANCVRIGDMGL 469
K+++D S + + P L +++ + +TD L+ L S ++L ++ C +I D G+
Sbjct: 25 KQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGM 84
Query: 470 KQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNI 529
G ++++ + + ++D SV +E CP L Y+ C +T++G+ ++ +
Sbjct: 85 IVIAKG--CLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCS-VTSKGVIHLTKL 141
Query: 530 FSLVSIDLSG-TDISNEG-LNVLSRHKKLKELSVSECYRITDDGIQ-------------- 573
+L S+DL T++ NE + ++ R K L L++ + I D ++
Sbjct: 142 RNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYL 201
Query: 574 ----ITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKK 629
ITD A+ + + +D+ C +TDQ + K LR L + C +++
Sbjct: 202 VSCKITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEV 261
Query: 630 AAQRMSSKVQQQEYNT 645
+++ VQQ + T
Sbjct: 262 TVEQL---VQQYPHIT 274
Score = 53.5 bits (127), Expect = 6e-07
Identities = 50/234 (21%), Positives = 96/234 (41%), Gaps = 31/234 (13%)
Query: 242 SHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNL-SNTTITNRTMRLLPRHFHNLQN 300
S CR L++++ C +DE M I++GC + + + N +T+++++ H LQ
Sbjct: 63 SKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQY 122
Query: 301 LSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDM 360
+ C T KG+ +L L LDL T++ + I C + L +
Sbjct: 123 VGFMGC-SVTSKGVIHL---TKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLN 178
Query: 361 PTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKF 420
+ D CV+ + ++ + L L +CK +TD +
Sbjct: 179 WIINDRCVEVIAKEGQNLKELY--------------LVSCK-----------ITDYALIA 213
Query: 421 IDKNYPNLSHIYMADCKGITDSSLRSLS-PLKQLTVLNLANCVRIGDMGLKQFL 473
I + + + + CK ITD ++ K L L L C ++ ++ ++Q +
Sbjct: 214 IGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLV 267
Score = 53.5 bits (127), Expect = 6e-07
Identities = 40/155 (25%), Positives = 73/155 (47%), Gaps = 4/155 (2%)
Query: 226 LNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLS-NTTIT 284
+ F GC + K ++ RNL L++ +E++ I + C + LNL N I
Sbjct: 123 VGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIIN 182
Query: 285 NRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRY 344
+R + ++ + NL+ L L C + TD L + +G + +D+ C +I+ QG
Sbjct: 183 DRCVEVIAKEGQNLKELYLVSC-KITDYAL--IAIGRYSMTIETVDVGWCKEITDQGATL 239
Query: 345 IANSCTGIMHLTINDMPTLTDNCVKALVEKCSRIT 379
IA S + +L + + + V+ LV++ IT
Sbjct: 240 IAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHIT 274
Score = 45.4 bits (106), Expect = 2e-04
Identities = 35/141 (24%), Positives = 65/141 (46%), Gaps = 32/141 (22%)
Query: 489 CVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLN 548
C +LSD S++ ++ CP L + + N + LT +EGL
Sbjct: 24 CKQLSDTSIIAVASHCPLLQKVHVGNQDKLT------------------------DEGLK 59
Query: 549 VL-SRHKKLKELSVSECYRITDDGIQITDSAMEMLSAKCHYLHILDISGCVLLTDQILED 607
L S+ ++LK++ +CY+I+D+G M +++ C L + + L+TDQ ++
Sbjct: 60 QLGSKCRELKDIHFGQCYKISDEG-------MIVIAKGCLKLQRIYMQENKLVTDQSVKA 112
Query: 608 LQIGCKQLRILKMQYCTNISK 628
C +L+ + C+ SK
Sbjct: 113 FAEHCPELQYVGFMGCSVTSK 133
Score = 33.1 bits (74), Expect = 0.88
Identities = 29/152 (19%), Positives = 62/152 (40%), Gaps = 30/152 (19%)
Query: 492 LSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLS 551
+SD V L+ +CP L + C+ L+ I + V S
Sbjct: 1 MSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSI-----------------------IAVAS 37
Query: 552 RHKKLKELSVSECYRITDDGIQITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIG 611
L+++ V ++TD+G++ L +KC L + C ++D+ + + G
Sbjct: 38 HCPLLQKVHVGNQDKLTDEGLK-------QLGSKCRELKDIHFGQCYKISDEGMIVIAKG 90
Query: 612 CKQLRILKMQYCTNISKKAAQRMSSKVQQQEY 643
C +L+ + MQ ++ ++ + + + +Y
Sbjct: 91 CLKLQRIYMQENKLVTDQSVKAFAEHCPELQY 122
>gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens]
Length = 479
Score = 71.6 bits (174), Expect = 2e-12
Identities = 60/203 (29%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 439 ITDSSLR-SLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASV 497
ITD+ L L ++ + L L+ C + GL L S RI L++S+C+ ++D ++
Sbjct: 205 ITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSL----SARITSLSVSDCINVADDAI 260
Query: 498 MKLSERCPNLNYLSLRNCEHLTAQGIGYIV--NIFSLVSIDL-SGTDISNEGL-NVLSRH 553
+S+ PNL LSL+ H+T + Y S ++ L S +I+N G+ NV+
Sbjct: 261 AAISQLLPNLAELSLQ-AYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSL 319
Query: 554 KKLKELSVSECYRITDDGIQITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCK 613
L LS+S C ++TDDG+ E+++ L LD+S C +TD LE +
Sbjct: 320 PNLTALSLSGCSKVTDDGV-------ELVAENLRKLRSLDLSWCPRITDMALEYVACDLH 372
Query: 614 QLRILKMQYCTNISKKAAQRMSS 636
+L L + C I+ +S+
Sbjct: 373 RLEELVLDRCVRITDTGLSYLST 395
Score = 67.8 bits (164), Expect = 3e-11
Identities = 72/304 (23%), Positives = 119/304 (39%), Gaps = 57/304 (18%)
Query: 223 VLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTT 282
V+RL GC + S + L+VSDC D+++ IS+ P + L+L
Sbjct: 220 VVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYH 279
Query: 283 ITNRTMRLLP-RHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQG 341
+T+ + R H+ L L C T+ G+ +N+ + L L LSGC+++
Sbjct: 280 VTDTALAYFTARQGHSTHTLRLLSCWEITNHGV--VNVVHSLPNLTALSLSGCSKV---- 333
Query: 342 FRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACK 401
TD+ V+ + E ++ SL + P
Sbjct: 334 ----------------------TDDGVELVAENLRKLRSLDLSWCP-------------- 357
Query: 402 LRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANC 461
R+TD + +++ + L + + C ITD+ L LS + L L L C
Sbjct: 358 ----------RITDMALEYVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWC 407
Query: 462 VRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQ 521
++ D GLK L A +R L+ + C L+ + L + L L L NC T +
Sbjct: 408 CQVQDFGLKHLL---ALGSLRLLSPAGCPLLTTTGLSGLVQ-LQELEELELTNCPGATPE 463
Query: 522 GIGY 525
Y
Sbjct: 464 LFKY 467
Score = 60.8 bits (146), Expect = 4e-09
Identities = 69/288 (23%), Positives = 122/288 (42%), Gaps = 54/288 (18%)
Query: 385 GAPHISDCTFRALSACKLRKIRFEGNKR--VTDASFKFIDKNYPNLSHIYMADCKGITDS 442
G + C F A + ++ KR +TDA + + + + + ++ C T++
Sbjct: 175 GVSDLDICEFIDNYALSKKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEA 234
Query: 443 SLRSLSPLKQLTVLNLANCVRIGD---MGLKQFLDGPASMRIRE---------------- 483
L S S ++T L++++C+ + D + Q L A + ++
Sbjct: 235 GLWS-SLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVTDTALAYFTARQG 293
Query: 484 -----LNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIV-NIFSLVSIDL 537
L L +C +++ V+ + PNL LSL C +T G+ + N+ L S+DL
Sbjct: 294 HSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVELVAENLRKLRSLDL 353
Query: 538 SG----TDISNEGLNVLSRHKKLKELSVSECYRITDDGI------------------QIT 575
S TD++ E V +L+EL + C RITD G+ Q+
Sbjct: 354 SWCPRITDMALE--YVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWCCQVQ 411
Query: 576 DSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYC 623
D ++ L A L +L +GC LLT L L + ++L L++ C
Sbjct: 412 DFGLKHLLA-LGSLRLLSPAGCPLLTTTGLSGL-VQLQELEELELTNC 457
Score = 47.8 bits (112), Expect = 3e-05
Identities = 41/154 (26%), Positives = 67/154 (43%), Gaps = 6/154 (3%)
Query: 246 NLQELNVSDCPTFTDESMRHISEGCPGVLCLNLS-NTTITNRTMRLLPRHFHNLQNLSLA 304
NL L++S C TD+ + ++E + L+LS IT+ + + H L+ L L
Sbjct: 321 NLTALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLD 380
Query: 305 YCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLT 364
C R TD GL YL+ + L L C Q+ G +++ + + L+ P LT
Sbjct: 381 RCVRITDTGLSYLSTMSSLRSLY---LRWCCQVQDFGLKHLL-ALGSLRLLSPAGCPLLT 436
Query: 365 DNCVKALVEKCSRITSLVFTGAPHISDCTFRALS 398
+ LV+ + L T P + F+ S
Sbjct: 437 TTGLSGLVQ-LQELEELELTNCPGATPELFKYFS 469
>gi|164663798 antagonist of mitotic exit network 1 homolog [Homo
sapiens]
Length = 258
Score = 71.2 bits (173), Expect = 3e-12
Identities = 69/265 (26%), Positives = 120/265 (45%), Gaps = 34/265 (12%)
Query: 363 LTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKFID 422
L D C+ ++ SR + + P+I D + +S ++TD++ I
Sbjct: 10 LLDLCLWCFMKNISRYLTDIKPLPPNIKDRLIKIMSM----------QGQITDSNISEI- 58
Query: 423 KNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNL----ANCVRIGDMGLKQFLDGPAS 478
+P + + + C I+D++L LS ++L LNL N V + G+K +
Sbjct: 59 -LHPEVQTLDLRSCD-ISDAALLHLSNCRKLKKLNLNASKGNRVSVTSEGIKAVAS--SC 114
Query: 479 MRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYI-VNIFSLVSIDL 537
+ E +L C L+D V+ L+ C L + L C +T + + N L +D
Sbjct: 115 SYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDF 174
Query: 538 SGTDISNEGLNVLSRH---KKLKELSVSECYRITDDGIQITDSAMEMLSAKCHYLHILDI 594
S T +S+ G+ L KKL+E+ + C + +TD A+E + C + IL
Sbjct: 175 SATQVSDSGVIALVSGPCAKKLEEIHMGHC-------VNLTDGAVEAVLTYCPQIRILLF 227
Query: 595 SGCVLLTD---QILEDLQIGCKQLR 616
GC L+TD ++LE L +G +L+
Sbjct: 228 HGCPLITDHSREVLEQL-VGPNKLK 251
Score = 52.0 bits (123), Expect = 2e-06
Identities = 52/201 (25%), Positives = 89/201 (44%), Gaps = 13/201 (6%)
Query: 198 IDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVS---- 253
I S++ I D I L V L+ R C + +S+CR L++LN++
Sbjct: 41 IKIMSMQGQITDSNISEILHP---EVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKG 97
Query: 254 DCPTFTDESMRHISEGCPGVLCLNLSN-TTITNRTMRLLPRHFHNLQNLSLAYCRRFTDK 312
+ + T E ++ ++ C + +L +T+ + L + L+ + L C TD
Sbjct: 98 NRVSVTSEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDV 157
Query: 313 GLQYLNLGNGCHKLIYLDLSGCTQISVQG-FRYIANSCT-GIMHLTINDMPTLTDNCVKA 370
L LG C L +D S TQ+S G ++ C + + + LTD V+A
Sbjct: 158 SLH--ALGKNCPFLQCVDFS-ATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEA 214
Query: 371 LVEKCSRITSLVFTGAPHISD 391
++ C +I L+F G P I+D
Sbjct: 215 VLTYCPQIRILLFHGCPLITD 235
Score = 51.2 bits (121), Expect = 3e-06
Identities = 27/94 (28%), Positives = 53/94 (56%), Gaps = 3/94 (3%)
Query: 534 SIDLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQITDSAMEMLSAKCHYLHILD 593
++DL DIS+ L LS +KLK+L+++ + + +T ++ +++ C YLH
Sbjct: 65 TLDLRSCDISDAALLHLSNCRKLKKLNLNAS---KGNRVSVTSEGIKAVASSCSYLHEAS 121
Query: 594 ISGCVLLTDQILEDLQIGCKQLRILKMQYCTNIS 627
+ C LTD+ + L + C+ L+I+ + C +I+
Sbjct: 122 LKRCCNLTDEGVVALALNCQLLKIIDLGGCLSIT 155
Score = 42.7 bits (99), Expect = 0.001
Identities = 43/177 (24%), Positives = 76/177 (42%), Gaps = 12/177 (6%)
Query: 298 LQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGC----TQISVQGFRYIANSCTGIM 353
+Q L L C +D L +L+ C KL L+L+ ++ +G + +A+SC+ +
Sbjct: 63 VQTLDLRSCD-ISDAALLHLS---NCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLH 118
Query: 354 HLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSA-CKLRKIRFEGNKR 412
++ LTD V AL C + + G I+D + AL C + +
Sbjct: 119 EASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSATQ 178
Query: 413 VTDASFKFIDKN--YPNLSHIYMADCKGITDSSLRS-LSPLKQLTVLNLANCVRIGD 466
V+D+ + L I+M C +TD ++ + L+ Q+ +L C I D
Sbjct: 179 VSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITD 235
>gi|16306588 F-box and leucine-rich repeat protein 4 [Homo sapiens]
Length = 621
Score = 70.1 bits (170), Expect = 7e-12
Identities = 49/160 (30%), Positives = 77/160 (48%), Gaps = 7/160 (4%)
Query: 468 GLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIV 527
G +FL S +R L LS L++ + +SE CPNL L+L +C+ L Q +I
Sbjct: 365 GFSRFLKVCGSELVR-LELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIA 423
Query: 528 NIFSLVSIDLSGTDISNEG-LNVLSRHKKLKELSVSECYRITDDGIQITDSAMEMLSAKC 586
+ SL + L T + L++L+ +L+ LS+ C I D D M+ AKC
Sbjct: 424 KLCSLKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIED-----YDVIASMIGAKC 478
Query: 587 HYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNI 626
L LD+ C +T+ + +L GC L L + +C +
Sbjct: 479 KKLRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTL 518
Score = 68.6 bits (166), Expect = 2e-11
Identities = 53/209 (25%), Positives = 93/209 (44%), Gaps = 5/209 (2%)
Query: 244 CRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSL 303
C NLQ LN+S C ++ HI++ C + L L T + + + LQ+LSL
Sbjct: 400 CPNLQALNLSSCDKLPPQAFNHIAKLC-SLKRLVLYRTKVEQTALLSILNFCSELQHLSL 458
Query: 304 AYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTL 363
C D + +G C KL LDL C I+ G +A+ C + L + PTL
Sbjct: 459 GSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTL 518
Query: 364 --TDNCVKALVEKCSRITSLVFTGAPHISDCTF--RALSACKLRKIRFEGNKRVTDASFK 419
+ C L + + L T + D A + +L+++ G + V+ AS +
Sbjct: 519 QSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILGTRMVSPASLR 578
Query: 420 FIDKNYPNLSHIYMADCKGITDSSLRSLS 448
+ ++ +LS + ++ C I + ++ L+
Sbjct: 579 KLLESCKDLSLLDVSFCSQIDNRAVLELN 607
Score = 60.5 bits (145), Expect = 5e-09
Identities = 67/304 (22%), Positives = 131/304 (43%), Gaps = 26/304 (8%)
Query: 349 CTGIMHLTINDMP---TLTDNCVKALVEKCSRIT--SLVFTG-APHISDCTF-RALSACK 401
C + ++ +N P L D ++ L +C+ + +L +TG IS F R L C
Sbjct: 315 CDPLQYIHLNLQPYWAKLDDTSLEFLQSRCTLVQWLNLSWTGNRGFISVAGFSRFLKVCG 374
Query: 402 LRKIRFE--GNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLA 459
+R E + + + + I + PNL + ++ C + + ++ L L L L
Sbjct: 375 SELVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCSLKRLVLY 434
Query: 460 NCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMK--LSERCPNLNYLSLRNCEH 517
++ L L+ ++ L+L +CV + D V+ + +C L L L C++
Sbjct: 435 R-TKVEQTALLSILN--FCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKN 491
Query: 518 LTAQGIGYIVNIFSLVS-IDLSGTDISNEGLNVLSR--HK--KLKELSVSECYRITDDGI 572
+T GI + + L+ +DL +R H+ L++L ++
Sbjct: 492 ITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTA-------NR 544
Query: 573 QITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQ 632
+ D+ ++ L+ C L LDI G +++ L L CK L +L + +C+ I +A
Sbjct: 545 SVCDTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVL 604
Query: 633 RMSS 636
+++
Sbjct: 605 ELNA 608
>gi|190194416 F-box and leucine-rich repeat protein 15 [Homo
sapiens]
Length = 300
Score = 59.7 bits (143), Expect = 9e-09
Identities = 40/162 (24%), Positives = 84/162 (51%), Gaps = 11/162 (6%)
Query: 480 RIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGI-GYIVNIFSLVSIDLS 538
++R + L C +LS ++ L+E CP L LSL +C+ + + G +L +DL+
Sbjct: 115 QLRSVALGGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRGLADRCPALEELDLT 174
Query: 539 GT-DISNEGLNVLSRHKK--LKELSVSECYRITDDGIQITDSAMEMLSAKCHYLHILDIS 595
+ +E + L++ + L+ LS++ + D+A++ L+ C LH LD++
Sbjct: 175 ACRQLKDEAIVYLAQRRGAGLRSLSLAV-------NANVGDAAVQELARNCPELHHLDLT 227
Query: 596 GCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSSK 637
GC+ + + L C LR L++++C ++++ + R+ +
Sbjct: 228 GCLRVGSDGVRTLAEYCPVLRSLRVRHCHHVAESSLSRLRKR 269
Score = 51.6 bits (122), Expect = 2e-06
Identities = 44/194 (22%), Positives = 82/194 (42%), Gaps = 7/194 (3%)
Query: 283 ITNRTMRLLPRHFHNLQNLSLAYCRRF-TDKGLQYLNLGNGCHKLIYLDLSGCTQISVQG 341
I + L R LQ L+LA C + +D+ L + N +L + L GC Q+S +
Sbjct: 74 IPRAALARLLRDAEGLQELALAPCHEWLSDEDLVPVLARNP--QLRSVALGGCGQLSRRA 131
Query: 342 FRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALS--- 398
+A C + L++ + ++ L ++C + L T + D L+
Sbjct: 132 LGALAEGCPRLQRLSLAHCDWVDGLALRGLADRCPALEELDLTACRQLKDEAIVYLAQRR 191
Query: 399 ACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSP-LKQLTVLN 457
LR + N V DA+ + + +N P L H+ + C + +R+L+ L L
Sbjct: 192 GAGLRSLSLAVNANVGDAAVQELARNCPELHHLDLTGCLRVGSDGVRTLAEYCPVLRSLR 251
Query: 458 LANCVRIGDMGLKQ 471
+ +C + + L +
Sbjct: 252 VRHCHHVAESSLSR 265
Score = 48.5 bits (114), Expect = 2e-05
Identities = 42/168 (25%), Positives = 74/168 (44%), Gaps = 5/168 (2%)
Query: 207 IPDKYIVSTLQRW-RLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRH 265
+ D+ +V L R +L + L G L R C LQ L+++ C ++R
Sbjct: 101 LSDEDLVPVLARNPQLRSVALGGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRG 160
Query: 266 ISEGCPGVLCLNLS--NTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGC 323
+++ CP + L+L+ + L R L++LSLA D +Q L C
Sbjct: 161 LADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDAAVQ--ELARNC 218
Query: 324 HKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKAL 371
+L +LDL+GC ++ G R +A C + L + + ++ + L
Sbjct: 219 PELHHLDLTGCLRVGSDGVRTLAEYCPVLRSLRVRHCHHVAESSLSRL 266
Score = 45.8 bits (107), Expect = 1e-04
Identities = 34/152 (22%), Positives = 67/152 (44%), Gaps = 2/152 (1%)
Query: 247 LQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTT-ITNRTMRLLPRHFHNLQNLSLAY 305
L+ + + C + ++ ++EGCP + L+L++ + +R L L+ L L
Sbjct: 116 LRSVALGGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRGLADRCPALEELDLTA 175
Query: 306 CRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTD 365
CR+ D+ + YL G L L L+ + + +A +C + HL + +
Sbjct: 176 CRQLKDEAIVYLAQRRGAG-LRSLSLAVNANVGDAAVQELARNCPELHHLDLTGCLRVGS 234
Query: 366 NCVKALVEKCSRITSLVFTGAPHISDCTFRAL 397
+ V+ L E C + SL H+++ + L
Sbjct: 235 DGVRTLAEYCPVLRSLRVRHCHHVAESSLSRL 266
>gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [Homo
sapiens]
Length = 1265
Score = 58.5 bits (140), Expect = 2e-08
Identities = 63/251 (25%), Positives = 102/251 (40%), Gaps = 39/251 (15%)
Query: 164 LQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIP-------DKYIVSTL 216
+ +F YLS +D+ +C +V W LW ID + K++ P + VS
Sbjct: 1002 MAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLD 1061
Query: 217 QRW-------------RLNVLR-LNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDES 262
W RL LR L GC + S C L+ L+V D
Sbjct: 1062 LSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQ 1121
Query: 263 MRHI----SEGCPG----------VLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRR 308
MR + ++ PG ++ L L+ IT+ ++RL+ RH L L L+YC
Sbjct: 1122 MRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNH 1181
Query: 309 FTDKGLQYLN-LGNGCH-KLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLT-D 365
TD+ + L +G L ++LS C +++ Q + C I H+ + +T +
Sbjct: 1182 VTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFF-KRCGNICHIDLRYCKQVTKE 1240
Query: 366 NCVKALVEKCS 376
C + + E S
Sbjct: 1241 GCEQFIAEMSS 1251
Score = 51.2 bits (121), Expect = 3e-06
Identities = 51/218 (23%), Positives = 96/218 (44%), Gaps = 38/218 (17%)
Query: 329 LDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPH 388
L LSGC+ I+V ++SC + L + + L D ++ L+ + P
Sbjct: 1085 LVLSGCSWIAVSAL--CSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPT-------DNRPG 1135
Query: 389 ISDCTFRALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS 448
D + + +LR + +TDAS + I ++ P LS ++++ C +TD S+ L+
Sbjct: 1136 QMDNRSKLRNIVELRLAGLD----ITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLT 1191
Query: 449 PLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLN 508
+ T +L E+NLS+C +++D + +RC N+
Sbjct: 1192 AVGTTTRDSLT-----------------------EINLSDCNKVTD-QCLSFFKRCGNIC 1227
Query: 509 YLSLRNCEHLTAQGI-GYIVNIFSLVSIDLSGTDISNE 545
++ LR C+ +T +G +I + S S T + +E
Sbjct: 1228 HIDLRYCKQVTKEGCEQFIAEMSSFQGRSCSTTRLGDE 1265
Score = 41.2 bits (95), Expect = 0.003
Identities = 42/179 (23%), Positives = 79/179 (44%), Gaps = 20/179 (11%)
Query: 413 VTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS-PLKQLTVLNLANCVRIGDMGLKQ 471
++ ++ P L + ++ C I S+L S S PL L L++ + D ++
Sbjct: 1067 ISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPL--LRTLDVQWVEGLKDAQMRD 1124
Query: 472 FLDGPASMRIRELN----LSNCVRL-------SDASVMKLSERCPNLNYLSLRNCEHLTA 520
L P R +++ L N V L +DAS+ + P L+ L L C H+T
Sbjct: 1125 LLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTD 1184
Query: 521 QGIGYIVNI-----FSLVSIDLSGTD-ISNEGLNVLSRHKKLKELSVSECYRITDDGIQ 573
Q I + + SL I+LS + ++++ L+ R + + + C ++T +G +
Sbjct: 1185 QSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCE 1243
>gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [Homo
sapiens]
Length = 1336
Score = 57.8 bits (138), Expect = 3e-08
Identities = 62/248 (25%), Positives = 101/248 (40%), Gaps = 39/248 (15%)
Query: 164 LQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIP-------DKYIVSTL 216
+ +F YLS +D+ +C +V W LW ID + K++ P + VS
Sbjct: 1071 MAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLD 1130
Query: 217 QRW-------------RLNVLR-LNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDES 262
W RL LR L GC + S C L+ L+V D
Sbjct: 1131 LSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQ 1190
Query: 263 MRHI----SEGCPG----------VLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRR 308
MR + ++ PG ++ L L+ IT+ ++RL+ RH L L L+YC
Sbjct: 1191 MRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNH 1250
Query: 309 FTDKGLQYLN-LGNGCH-KLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLT-D 365
TD+ + L +G L ++LS C +++ Q + C I H+ + +T +
Sbjct: 1251 VTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFF-KRCGNICHIDLRYCKQVTKE 1309
Query: 366 NCVKALVE 373
C + + E
Sbjct: 1310 GCEQFIAE 1317
Score = 50.4 bits (119), Expect = 5e-06
Identities = 46/194 (23%), Positives = 87/194 (44%), Gaps = 37/194 (19%)
Query: 329 LDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPH 388
L LSGC+ I+V ++SC + L + + L D ++ L+ + P
Sbjct: 1154 LVLSGCSWIAVSAL--CSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPT-------DNRPG 1204
Query: 389 ISDCTFRALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS 448
D + + +LR + +TDAS + I ++ P LS ++++ C +TD S+ L+
Sbjct: 1205 QMDNRSKLRNIVELRLAGLD----ITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLT 1260
Query: 449 PLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLN 508
+ T +L E+NLS+C +++D + +RC N+
Sbjct: 1261 AVGTTTRDSLT-----------------------EINLSDCNKVTD-QCLSFFKRCGNIC 1296
Query: 509 YLSLRNCEHLTAQG 522
++ LR C+ +T +G
Sbjct: 1297 HIDLRYCKQVTKEG 1310
Score = 41.2 bits (95), Expect = 0.003
Identities = 42/179 (23%), Positives = 79/179 (44%), Gaps = 20/179 (11%)
Query: 413 VTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS-PLKQLTVLNLANCVRIGDMGLKQ 471
++ ++ P L + ++ C I S+L S S PL L L++ + D ++
Sbjct: 1136 ISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPL--LRTLDVQWVEGLKDAQMRD 1193
Query: 472 FLDGPASMRIRELN----LSNCVRL-------SDASVMKLSERCPNLNYLSLRNCEHLTA 520
L P R +++ L N V L +DAS+ + P L+ L L C H+T
Sbjct: 1194 LLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTD 1253
Query: 521 QGIGYIVNI-----FSLVSIDLSGTD-ISNEGLNVLSRHKKLKELSVSECYRITDDGIQ 573
Q I + + SL I+LS + ++++ L+ R + + + C ++T +G +
Sbjct: 1254 QSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCE 1312
>gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo
sapiens]
Length = 424
Score = 55.1 bits (131), Expect = 2e-07
Identities = 94/401 (23%), Positives = 156/401 (38%), Gaps = 85/401 (21%)
Query: 121 KNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQ 180
K+ +I++R NFP S LP+ +L IF L L +++
Sbjct: 77 KDFVIVRRPKLNRENFPGVSWDS--------------LPDELLLGIFSCLCLPELLKVSG 122
Query: 181 VNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRS 240
V W + SLW +D + KN+ PD RL +G + FR
Sbjct: 123 VCKRWYRLASDESLWQTLDLTG-KNLHPDV------------TGRLLSQGVI----AFR- 164
Query: 241 VSHCRNLQELNVSDCP-TFTDESM-RHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNL 298
CP +F D+ + H S V ++LSN+ I T+ + L
Sbjct: 165 --------------CPRSFMDQPLAEHFSPF--RVQHMDLSNSVIEVSTLHGILSQCSKL 208
Query: 299 QNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTIN 358
QNLSL R +D + L + L+ L+LSGC+ S + + +SC+ + L ++
Sbjct: 209 QNLSLEGLR-LSDPIVNTLAKNSN---LVRLNLSGCSGFSEFALQTLLSSCSRLDELNLS 264
Query: 359 DMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASF 418
T+ V+ V H+S+ T L+ RK N + +D S
Sbjct: 265 WCFDFTEKHVQVAV--------------AHVSE-TITQLNLSGYRK-----NLQKSDLS- 303
Query: 419 KFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPAS 478
+ + PNL H+ ++D + + + L L L+L+ C I L + + P
Sbjct: 304 -TLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTL 362
Query: 479 MRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLT 519
++ + + D ++ L E P+L NC H T
Sbjct: 363 KTLQVFGI-----VPDGTLQLLKEALPHLQI----NCSHFT 394
Score = 38.5 bits (88), Expect = 0.021
Identities = 35/131 (26%), Positives = 64/131 (48%), Gaps = 20/131 (15%)
Query: 503 RCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLN-VLSRHKKLKELSV 561
RCP +++ EH + F + +DLS + I L+ +LS+ KL+ LS+
Sbjct: 164 RCPR-SFMDQPLAEHFSP---------FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSL 213
Query: 562 SECYRITDDGIQITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQ 621
+G++++D + L AK L L++SGC ++ L+ L C +L L +
Sbjct: 214 --------EGLRLSDPIVNTL-AKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLS 264
Query: 622 YCTNISKKAAQ 632
+C + ++K Q
Sbjct: 265 WCFDFTEKHVQ 275
Score = 31.6 bits (70), Expect = 2.6
Identities = 34/130 (26%), Positives = 57/130 (43%), Gaps = 13/130 (10%)
Query: 484 LNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFS--LVSIDLSG-- 539
LNLS C S+ ++ L C L+ L+L C T + + V S + ++LSG
Sbjct: 235 LNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYR 294
Query: 540 TDISNEGLNVLSRH-KKLKELSVSECYRITDDGIQITDSAMEMLSAKCHYLHILDISGCV 598
++ L+ L R L L +S+ + +D Q E + +YL L +S C
Sbjct: 295 KNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQ------EFF--QLNYLQHLSLSRCY 346
Query: 599 LLTDQILEDL 608
+ + L +L
Sbjct: 347 DIIPETLLEL 356
>gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens]
Length = 223
Score = 54.3 bits (129), Expect = 4e-07
Identities = 46/170 (27%), Positives = 83/170 (48%), Gaps = 36/170 (21%)
Query: 475 GPASMRIR---ELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFS 531
GP+ + +R EL+L+ C +L+DAS+ K+ L +L LR
Sbjct: 68 GPSLLTLRALQELDLTACSKLTDASLAKV------LQFLQLRQ----------------- 104
Query: 532 LVSIDLSGTDISNEGLNVLSRH-KKLKELSVSECYRITDDGIQITDSAMEMLSAKCHYLH 590
+S+ L ++++ GL ++R L+ L++S C R++D G S+ L
Sbjct: 105 -LSLSLL-PELTDNGLVAVARGCPSLEHLALSHCSRLSDKGWAQAASSWPRLQH------ 156
Query: 591 ILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSSKVQQ 640
L++S C L +Q L+ + C+QLR+L + C I+ A +R +++ Q
Sbjct: 157 -LNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGINMAAVRRFQAQLPQ 205
Score = 52.0 bits (123), Expect = 2e-06
Identities = 39/155 (25%), Positives = 66/155 (42%), Gaps = 28/155 (18%)
Query: 245 RNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSLA 304
R LQEL+++ C TD S+ + + F L+ LSL+
Sbjct: 75 RALQELDLTACSKLTDASLAKVLQ--------------------------FLQLRQLSLS 108
Query: 305 YCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLT 364
TD GL + + GC L +L LS C+++S +G+ A+S + HL ++ L
Sbjct: 109 LLPELTDNGL--VAVARGCPSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLI 166
Query: 365 DNCVKALVEKCSRITSLVFTGAPHISDCTFRALSA 399
+ + A+ + C ++ L P I+ R A
Sbjct: 167 EQTLDAIGQACRQLRVLDVATCPGINMAAVRRFQA 201
Score = 44.3 bits (103), Expect = 4e-04
Identities = 31/140 (22%), Positives = 70/140 (50%), Gaps = 8/140 (5%)
Query: 378 ITSLVFTGAPHISDCTF-RALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADC 436
+ L T ++D + + L +LR++ +TD + + P+L H+ ++ C
Sbjct: 77 LQELDLTACSKLTDASLAKVLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSHC 136
Query: 437 KGITDSS-LRSLSPLKQLTVLNLANCVRIGDMGLKQFLD--GPASMRIRELNLSNCVRLS 493
++D ++ S +L LNL++C ++ ++Q LD G A ++R L+++ C ++
Sbjct: 137 SRLSDKGWAQAASSWPRLQHLNLSSCSQL----IEQTLDAIGQACRQLRVLDVATCPGIN 192
Query: 494 DASVMKLSERCPNLNYLSLR 513
A+V + + P ++ + R
Sbjct: 193 MAAVRRFQAQLPQVSCVQSR 212
>gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens]
Length = 223
Score = 54.3 bits (129), Expect = 4e-07
Identities = 46/170 (27%), Positives = 83/170 (48%), Gaps = 36/170 (21%)
Query: 475 GPASMRIR---ELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFS 531
GP+ + +R EL+L+ C +L+DAS+ K+ L +L LR
Sbjct: 68 GPSLLTLRALQELDLTACSKLTDASLAKV------LQFLQLRQ----------------- 104
Query: 532 LVSIDLSGTDISNEGLNVLSRH-KKLKELSVSECYRITDDGIQITDSAMEMLSAKCHYLH 590
+S+ L ++++ GL ++R L+ L++S C R++D G S+ L
Sbjct: 105 -LSLSLL-PELTDNGLVAVARGCPSLEHLALSHCSRLSDKGWAQAASSWPRLQH------ 156
Query: 591 ILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSSKVQQ 640
L++S C L +Q L+ + C+QLR+L + C I+ A +R +++ Q
Sbjct: 157 -LNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGINMAAVRRFQAQLPQ 205
Score = 52.0 bits (123), Expect = 2e-06
Identities = 39/155 (25%), Positives = 66/155 (42%), Gaps = 28/155 (18%)
Query: 245 RNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSLA 304
R LQEL+++ C TD S+ + + F L+ LSL+
Sbjct: 75 RALQELDLTACSKLTDASLAKVLQ--------------------------FLQLRQLSLS 108
Query: 305 YCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLT 364
TD GL + + GC L +L LS C+++S +G+ A+S + HL ++ L
Sbjct: 109 LLPELTDNGL--VAVARGCPSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLI 166
Query: 365 DNCVKALVEKCSRITSLVFTGAPHISDCTFRALSA 399
+ + A+ + C ++ L P I+ R A
Sbjct: 167 EQTLDAIGQACRQLRVLDVATCPGINMAAVRRFQA 201
Score = 44.3 bits (103), Expect = 4e-04
Identities = 31/140 (22%), Positives = 70/140 (50%), Gaps = 8/140 (5%)
Query: 378 ITSLVFTGAPHISDCTF-RALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADC 436
+ L T ++D + + L +LR++ +TD + + P+L H+ ++ C
Sbjct: 77 LQELDLTACSKLTDASLAKVLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSHC 136
Query: 437 KGITDSS-LRSLSPLKQLTVLNLANCVRIGDMGLKQFLD--GPASMRIRELNLSNCVRLS 493
++D ++ S +L LNL++C ++ ++Q LD G A ++R L+++ C ++
Sbjct: 137 SRLSDKGWAQAASSWPRLQHLNLSSCSQL----IEQTLDAIGQACRQLRVLDVATCPGIN 192
Query: 494 DASVMKLSERCPNLNYLSLR 513
A+V + + P ++ + R
Sbjct: 193 MAAVRRFQAQLPQVSCVQSR 212
>gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens]
Length = 1162
Score = 53.9 bits (128), Expect = 5e-07
Identities = 71/284 (25%), Positives = 106/284 (37%), Gaps = 71/284 (25%)
Query: 154 DISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKY-- 211
D S + + +F YLS +++ C +V W LW ID S K ++P
Sbjct: 889 DESWMQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSG 948
Query: 212 ---------------IVSTLQRWRLNVL----RLNFRGCLLRPKTFRSVSHCRNLQELNV 252
I W +N L L GC + S S C L+ L++
Sbjct: 949 IIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDL 1008
Query: 253 SDCPTFTDESMRHI---SEGCPG---------VLCLNLSNTTITNRTMRLLPRHFHNLQN 300
D +R + PG + L+ IT+ T+RL+ RH L
Sbjct: 1009 RWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSR 1068
Query: 301 LSLAYCRRFTDK--------------GLQYLNLGNGCHK-----LIYL---------DLS 332
L L++C TD+ L LN+ GC+K LIYL DL
Sbjct: 1069 LDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMA-GCNKLTDQTLIYLRRIANVTLIDLR 1127
Query: 333 GCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCS 376
GC QI+ + + I L+IN + L+D + L++K S
Sbjct: 1128 GCKQITRKACEHF------ISDLSINSLYCLSD---EKLIQKIS 1162
Score = 46.2 bits (108), Expect = 1e-04
Identities = 54/224 (24%), Positives = 94/224 (41%), Gaps = 44/224 (19%)
Query: 327 IYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKAL-VEKCSRITSLVFTG 385
+ LDLS T IS + ++ N G+ L + + V AL C + +L
Sbjct: 955 VSLDLSW-TNISKKQLTWLVNRLPGLKDLLLAGCSW---SAVSALSTSSCPLLRTLDLRW 1010
Query: 386 APHISDCTFRAL-----------SACKLRKI---RFEGNKRVTDASFKFIDKNYPNLSHI 431
A I D R L + KLR + R G +TDA+ + I ++ P LS +
Sbjct: 1011 AVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLD-ITDATLRLIIRHMPLLSRL 1069
Query: 432 YMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVR 491
++ C +TD S L+ + T +L ELN++ C +
Sbjct: 1070 DLSHCSHLTDQSSNLLTAVGSSTRYSLT-----------------------ELNMAGCNK 1106
Query: 492 LSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSI 535
L+D +++ L R N+ + LR C+ +T + + ++ S+ S+
Sbjct: 1107 LTDQTLIYL-RRIANVTLIDLRGCKQITRKACEHFISDLSINSL 1149
Score = 42.0 bits (97), Expect = 0.002
Identities = 48/195 (24%), Positives = 86/195 (44%), Gaps = 29/195 (14%)
Query: 426 PNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASM-----R 480
P L + +A C S+L S S L L+L V I D ++ L PA R
Sbjct: 977 PGLKDLLLAGCSWSAVSAL-STSSCPLLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNR 1035
Query: 481 IRELNLSNC----VRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNI-----FS 531
+ N+++ + ++DA++ + P L+ L L +C HLT Q + + +S
Sbjct: 1036 SKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYS 1095
Query: 532 LVSIDLSGTD-ISNEGLNVLSRHKKLKELSVSECYRITDDGIQITDSAMEMLSAKCHYLH 590
L ++++G + ++++ L L R + + + C QIT A E H++
Sbjct: 1096 LTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCK-------QITRKACE------HFIS 1142
Query: 591 ILDISGCVLLTDQIL 605
L I+ L+D+ L
Sbjct: 1143 DLSINSLYCLSDEKL 1157
Score = 34.7 bits (78), Expect = 0.30
Identities = 54/258 (20%), Positives = 101/258 (39%), Gaps = 37/258 (14%)
Query: 249 ELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRR 308
++++S C +++ I + P + L+LS T I+ + + L L++L LA C
Sbjct: 932 KIDLSRCKAIVPQALSGIIKRQP--VSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGC-- 987
Query: 309 FTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTL-TDNC 367
+ L S C + R+ GI I D+ T D
Sbjct: 988 -------------SWSAVSALSTSSCPLLRTLDLRW----AVGIKDPQIRDLLTPPADKP 1030
Query: 368 VKALVEKCSRITSLVFTGAPHISDCTFRALSACK--LRKIRFEGNKRVTDASFKFI---- 421
+ K +T G I+D T R + L ++ +TD S +
Sbjct: 1031 GQDNRSKLRNMTDFRLAGLD-ITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVG 1089
Query: 422 DKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRI 481
+L+ + MA C +TD +L L + +T+++L C +I + F I
Sbjct: 1090 SSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHF--------I 1141
Query: 482 RELNLSNCVRLSDASVMK 499
+L++++ LSD +++
Sbjct: 1142 SDLSINSLYCLSDEKLIQ 1159
>gi|16306576 F-box and leucine-rich repeat protein 6 isoform 1 [Homo
sapiens]
Length = 539
Score = 52.0 bits (123), Expect = 2e-06
Identities = 72/317 (22%), Positives = 115/317 (36%), Gaps = 65/317 (20%)
Query: 290 LLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSC 349
L+P F LQ L+L + + L+ + G C +L +L LSGC ++ +A +C
Sbjct: 188 LMPNRFSQLQRLTLIHWKSQVHPVLKLV--GECCPRLTFLKLSGCHGVTADALVMLAKAC 245
Query: 350 TGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEG 409
+ L + + V L E SR+ L T + + L +C
Sbjct: 246 CQLHSLDLQHSMVESTAVVSFLEEAGSRMRKLWLTYSSQTTAILGALLGSC--------- 296
Query: 410 NKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLK-------QLTVLNLANCV 462
P L + ++ GI +S+ P++ QL VL L N +
Sbjct: 297 ---------------CPQLQVLEVST--GINRNSIPLQLPVEALQKGCPQLQVLRLLNLM 339
Query: 463 RIGDMGLKQFLDGPASMRIRELNL--SNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTA 520
+ + GP + EL L S C +S+ + +L PNL L LR C +T
Sbjct: 340 WLPKPPGRGVAPGPGFPSLEELCLASSTCNFVSNEVLGRLLHGSPNLRLLDLRGCARITP 399
Query: 521 QGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQITDSAME 580
G+ DL ++ L + T D + +
Sbjct: 400 AGLQ-----------DLPCRELEQLHLGLYG----------------TSDRLTLAKEGSP 432
Query: 581 MLSAK-CHYLHILDISG 596
L+ K CH L LD+SG
Sbjct: 433 FLTQKWCHTLRELDLSG 449
>gi|157168349 F-box and leucine-rich repeat protein 19 [Homo
sapiens]
Length = 694
Score = 51.6 bits (122), Expect = 2e-06
Identities = 52/221 (23%), Positives = 93/221 (42%), Gaps = 43/221 (19%)
Query: 158 LPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQ 217
LP A L++F +L +++ IC +V W LW +D S K++ P ++S +
Sbjct: 424 LPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPP--MLSGVV 481
Query: 218 RWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFT------------------ 259
R + L L++ G + + + ++ + LQEL +S C +
Sbjct: 482 RRQPRALDLSWTG-VSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLR 540
Query: 260 ------DESMRHI-------------SEG-CPGVLCLNLSNTTITNRTMRLLPRHFHNLQ 299
D +R + S G GV L L+ +T+ ++RLL RH L
Sbjct: 541 WIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLS 600
Query: 300 NLSLAYCRRFTDKGLQYLNLGNG--CHKLIYLDLSGCTQIS 338
L L++C D + L L++L+L+GC +++
Sbjct: 601 ALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLT 641
Score = 48.1 bits (113), Expect = 3e-05
Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 8/98 (8%)
Query: 413 VTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSL----SPLKQLTV-LNLANCVRIGDM 467
+TDAS + + ++ P LS + ++ C + D S+ L SPL++ V LNLA C R+ D
Sbjct: 584 LTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDH 643
Query: 468 GLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCP 505
L F P R+R L+L +C +LS + +L+ P
Sbjct: 644 CLPLFRRCP---RLRRLDLRSCRQLSPEACARLAAAGP 678
Score = 40.0 bits (92), Expect = 0.007
Identities = 38/161 (23%), Positives = 75/161 (46%), Gaps = 20/161 (12%)
Query: 428 LSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMR------- 480
L + ++ C ++ S+L S +PL L +L+L + D L++ L P +
Sbjct: 510 LQELVLSGCSWLSVSALGS-APLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESR 568
Query: 481 -----IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFS---- 531
+ EL L+ + L+DAS+ L P L+ L L +C H+ + + S
Sbjct: 569 GRLQGVAELRLAG-LELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRE 627
Query: 532 -LVSIDLSGTD-ISNEGLNVLSRHKKLKELSVSECYRITDD 570
LV ++L+G +++ L + R +L+ L + C +++ +
Sbjct: 628 TLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCRQLSPE 668
>gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo
sapiens]
Length = 410
Score = 51.2 bits (121), Expect = 3e-06
Identities = 95/400 (23%), Positives = 158/400 (39%), Gaps = 80/400 (20%)
Query: 121 KNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQ 180
K+ +I++R NFP S LP+ +L IF L L +++
Sbjct: 77 KDFVIVRRPKLNRENFPGVSWDS--------------LPDELLLGIFSCLCLPELLKVSG 122
Query: 181 VNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRS 240
V W + SLW +D + KN+ PD RL +G + FR
Sbjct: 123 VCKRWYRLASDESLWQTLDLTG-KNLHPDV------------TGRLLSQGVI----AFR- 164
Query: 241 VSHCRNLQELNVSDCP-TFTDESM-RHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNL 298
CP +F D+ + H S V ++LSN+ I T+ + L
Sbjct: 165 --------------CPRSFMDQPLAEHFSPF--RVQHMDLSNSVIEVSTLHGILSQCSKL 208
Query: 299 QNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTIN 358
QNLSL R +D + L + L+ L+LSGC+ S + + +SC+ + L ++
Sbjct: 209 QNLSLEGLR-LSDPIVNTLAKNSN---LVRLNLSGCSGFSEFALQTLLSSCSRLDELNLS 264
Query: 359 DMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASF 418
T+ V+ V H+S+ T L+ RK N + +D S
Sbjct: 265 WCFDFTEKHVQVAV--------------AHVSE-TITQLNLSGYRK-----NLQKSDLS- 303
Query: 419 KFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPAS 478
+ + PNL H+ ++D + + + L L L+L+ C I L L A
Sbjct: 304 -TLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETL--LLVTRAG 360
Query: 479 MRIRELNLSNCVRLSDASVMKLSER--CPNLNYLSLRNCE 516
+RIR + C + S +K S + C ++ + + C+
Sbjct: 361 VRIRLDSDIGCPQTYRTSKLKSSHKLFCQHVRVICIFVCD 400
Score = 38.5 bits (88), Expect = 0.021
Identities = 35/131 (26%), Positives = 64/131 (48%), Gaps = 20/131 (15%)
Query: 503 RCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLN-VLSRHKKLKELSV 561
RCP +++ EH + F + +DLS + I L+ +LS+ KL+ LS+
Sbjct: 164 RCPR-SFMDQPLAEHFSP---------FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSL 213
Query: 562 SECYRITDDGIQITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQ 621
+G++++D + L AK L L++SGC ++ L+ L C +L L +
Sbjct: 214 --------EGLRLSDPIVNTL-AKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLS 264
Query: 622 YCTNISKKAAQ 632
+C + ++K Q
Sbjct: 265 WCFDFTEKHVQ 275
Score = 31.6 bits (70), Expect = 2.6
Identities = 40/147 (27%), Positives = 63/147 (42%), Gaps = 24/147 (16%)
Query: 484 LNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFS--LVSIDLSG-- 539
LNLS C S+ ++ L C L+ L+L C T + + V S + ++LSG
Sbjct: 235 LNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYR 294
Query: 540 TDISNEGLNVLSRH-KKLKELSVSECYRITDDGIQITDSAMEMLSAKCHYLHILDISGC- 597
++ L+ L R L L +S+ + +D Q E + +YL L +S C
Sbjct: 295 KNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQ------EFF--QLNYLQHLSLSRCY 346
Query: 598 -------VLLTD---QILEDLQIGCKQ 614
+L+T +I D IGC Q
Sbjct: 347 DIIPETLLLVTRAGVRIRLDSDIGCPQ 373
>gi|61742136 F-box and leucine-rich repeat protein 6 isoform 2 [Homo
sapiens]
Length = 533
Score = 49.7 bits (117), Expect = 9e-06
Identities = 71/317 (22%), Positives = 113/317 (35%), Gaps = 71/317 (22%)
Query: 290 LLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSC 349
L+P F LQ L+L + + +G C +L +L LSGC ++ +A +C
Sbjct: 188 LMPNRFSQLQRLTLIHWKSQL--------VGECCPRLTFLKLSGCHGVTADALVMLAKAC 239
Query: 350 TGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEG 409
+ L + + V L E SR+ L T + + L +C
Sbjct: 240 CQLHSLDLQHSMVESTAVVSFLEEAGSRMRKLWLTYSSQTTAILGALLGSC--------- 290
Query: 410 NKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLK-------QLTVLNLANCV 462
P L + ++ GI +S+ P++ QL VL L N +
Sbjct: 291 ---------------CPQLQVLEVST--GINRNSIPLQLPVEALQKGCPQLQVLRLLNLM 333
Query: 463 RIGDMGLKQFLDGPASMRIRELNL--SNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTA 520
+ + GP + EL L S C +S+ + +L PNL L LR C +T
Sbjct: 334 WLPKPPGRGVAPGPGFPSLEELCLASSTCNFVSNEVLGRLLHGSPNLRLLDLRGCARITP 393
Query: 521 QGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQITDSAME 580
G+ DL ++ L + T D + +
Sbjct: 394 AGLQ-----------DLPCRELEQLHLGLYG----------------TSDRLTLAKEGSP 426
Query: 581 MLSAK-CHYLHILDISG 596
L+ K CH L LD+SG
Sbjct: 427 FLTQKWCHTLRELDLSG 443
>gi|16306574 F-box and leucine-rich repeat protein 5 isoform 2 [Homo
sapiens]
Length = 565
Score = 48.1 bits (113), Expect = 3e-05
Identities = 121/565 (21%), Positives = 211/565 (37%), Gaps = 73/565 (12%)
Query: 98 ARHKSKKKEDELILKHELQLKKWKNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISL 157
A+H S+K EL+ L + + K + E+S+ S I+
Sbjct: 30 AQHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEH--------STGITH 81
Query: 158 LPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQ 217
LP +L IF YL+ +++ C QV+ W +T+ SLW K++ P +
Sbjct: 82 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLW--------KHLYPVHWARGDWY 133
Query: 218 RWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLN 277
L ++ + S + ++ ++ + +ES+ +
Sbjct: 134 SGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESI--------AISIAQ 185
Query: 278 LSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGL-QYLNLGNGCHKLIYLDLSGCTQ 336
+ + +LP +++ L LAY + K + Q L L C L +LDL+ T
Sbjct: 186 MEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILEL---CPNLEHLDLTQ-TD 241
Query: 337 ISVQGFRYIA--NSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTF 394
IS F + C + HL ++ +TD +EK SR ++ H S F
Sbjct: 242 ISDSAFDSWSWLGCCQSLRHLDLSGCEKITD----VALEKISRALGIL---TSHQSG--F 292
Query: 395 RALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLT 454
S K+ ++ NK +T S K + ++ KGI + K ++
Sbjct: 293 LKTSTSKITSTAWK-NKDITMQSTK-------QYACLHDLTNKGIGEEIDNEHPWTKPVS 344
Query: 455 VLNLANCVRIGDMGLKQFLDGPASMRIRELNL-SNCVRLSDASVMKLSERCPNLNYLSLR 513
N + + + + D ++ R N+ S CV + ++ + C + + + LR
Sbjct: 345 SENFTS-PYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLR 403
Query: 514 NC----EHLTAQGIGYIVNIF--------SLVSIDLSGTDISNEGLNVLSRHKKL----K 557
+H + Y + F ++ S+ S L R K L
Sbjct: 404 TSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGS 463
Query: 558 ELSVSECYRI-----TDDGIQITDSAMEMLS--AKCHYLHILDISGCVLLTDQILEDLQI 610
E S E R+ QITD + +L+ YL L++SGC+ +T L+DL
Sbjct: 464 EKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVS 523
Query: 611 GCKQLRILKMQYCTNISKKAAQRMS 635
C L YC NI+ A S
Sbjct: 524 ACPSLNDEYFYYCDNINGPHADTAS 548
Score = 32.3 bits (72), Expect = 1.5
Identities = 21/78 (26%), Positives = 35/78 (44%), Gaps = 2/78 (2%)
Query: 326 LIYLDLSGCTQISVQGFRY--IANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVF 383
L++L LSGC QI+ G R + + HL ++ T+T ++ LV C + F
Sbjct: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
Query: 384 TGAPHISDCTFRALSACK 401
+I+ S C+
Sbjct: 534 YYCDNINGPHADTASGCQ 551
>gi|16306572 F-box and leucine-rich repeat protein 5 isoform 1 [Homo
sapiens]
Length = 691
Score = 48.1 bits (113), Expect = 3e-05
Identities = 121/565 (21%), Positives = 211/565 (37%), Gaps = 73/565 (12%)
Query: 98 ARHKSKKKEDELILKHELQLKKWKNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISL 157
A+H S+K EL+ L + + K + E+S+ S I+
Sbjct: 156 AQHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEH--------STGITH 207
Query: 158 LPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQ 217
LP +L IF YL+ +++ C QV+ W +T+ SLW K++ P +
Sbjct: 208 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLW--------KHLYPVHWARGDWY 259
Query: 218 RWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLN 277
L ++ + S + ++ ++ + +ES+ +
Sbjct: 260 SGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESI--------AISIAQ 311
Query: 278 LSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGL-QYLNLGNGCHKLIYLDLSGCTQ 336
+ + +LP +++ L LAY + K + Q L L C L +LDL+ T
Sbjct: 312 MEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILEL---CPNLEHLDLTQ-TD 367
Query: 337 ISVQGFRYIA--NSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTF 394
IS F + C + HL ++ +TD +EK SR ++ H S F
Sbjct: 368 ISDSAFDSWSWLGCCQSLRHLDLSGCEKITD----VALEKISRALGIL---TSHQSG--F 418
Query: 395 RALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLT 454
S K+ ++ NK +T S K + ++ KGI + K ++
Sbjct: 419 LKTSTSKITSTAWK-NKDITMQSTK-------QYACLHDLTNKGIGEEIDNEHPWTKPVS 470
Query: 455 VLNLANCVRIGDMGLKQFLDGPASMRIRELNL-SNCVRLSDASVMKLSERCPNLNYLSLR 513
N + + + + D ++ R N+ S CV + ++ + C + + + LR
Sbjct: 471 SENFTS-PYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLR 529
Query: 514 NC----EHLTAQGIGYIVNIF--------SLVSIDLSGTDISNEGLNVLSRHKKL----K 557
+H + Y + F ++ S+ S L R K L
Sbjct: 530 TSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGS 589
Query: 558 ELSVSECYRI-----TDDGIQITDSAMEMLS--AKCHYLHILDISGCVLLTDQILEDLQI 610
E S E R+ QITD + +L+ YL L++SGC+ +T L+DL
Sbjct: 590 EKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVS 649
Query: 611 GCKQLRILKMQYCTNISKKAAQRMS 635
C L YC NI+ A S
Sbjct: 650 ACPSLNDEYFYYCDNINGPHADTAS 674
Score = 32.3 bits (72), Expect = 1.5
Identities = 21/78 (26%), Positives = 35/78 (44%), Gaps = 2/78 (2%)
Query: 326 LIYLDLSGCTQISVQGFRY--IANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVF 383
L++L LSGC QI+ G R + + HL ++ T+T ++ LV C + F
Sbjct: 600 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 659
Query: 384 TGAPHISDCTFRALSACK 401
+I+ S C+
Sbjct: 660 YYCDNINGPHADTASGCQ 677
>gi|16506299 leucine rich repeat containing 42 [Homo sapiens]
Length = 428
Score = 43.9 bits (102), Expect = 5e-04
Identities = 35/115 (30%), Positives = 56/115 (48%), Gaps = 12/115 (10%)
Query: 439 ITDSSLRSLSPLKQLTVLNLANCVRIGDMG-LKQFLDGPASMRIRELNLS-NCVRLSDAS 496
+ L + ++LT L+L+ C ++GD L + L A + +L+L NC LSDA
Sbjct: 161 VISEKLEEIKSFRELTCLDLS-CCKLGDEHELLEHLTNEALSSVTQLHLKDNC--LSDAG 217
Query: 497 VMKLS-------ERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISN 544
V K++ NL L L +T GIGY+ + L +D+SGT + +
Sbjct: 218 VRKMTAPVRVMKRGLENLTLLDLSCNPEITDAGIGYLFSFRKLNCLDISGTGLKD 272
Score = 30.0 bits (66), Expect = 7.5
Identities = 29/123 (23%), Positives = 55/123 (44%), Gaps = 8/123 (6%)
Query: 236 KTFRSVSHCRNLQELNVSD----CPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLL 291
K+FR ++ C +L + D T+E++ +++ CL+ + +R++
Sbjct: 170 KSFRELT-CLDLSCCKLGDEHELLEHLTNEALSSVTQLHLKDNCLSDAGVRKMTAPVRVM 228
Query: 292 PRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTG 351
R NL L L+ TD G+ YL KL LD+SG ++ ++ + G
Sbjct: 229 KRGLENLTLLDLSCNPEITDAGIGYL---FSFRKLNCLDISGTGLKDIKTVKHKLQTHIG 285
Query: 352 IMH 354
++H
Sbjct: 286 LVH 288
>gi|148922963 F-box and leucine-rich repeat protein 21 [Homo
sapiens]
Length = 434
Score = 41.2 bits (95), Expect = 0.003
Identities = 85/380 (22%), Positives = 156/380 (41%), Gaps = 53/380 (13%)
Query: 150 TLKCDISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDF-------SS 202
T+ D LP +LQIF YL L D V W + ++ LW +F SS
Sbjct: 37 TVLLDWGSLPHHVVLQIFQYLPLLDRACASSVCRRWNEVFHISDLWRKFEFELNQSATSS 96
Query: 203 VKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDES 262
K+ PD I +++ ++ ++F+ + + + C L +L +C + ++
Sbjct: 97 FKSTHPD-LIQQIIKKHFAHLQYVSFK---VDSSAESAEAACDILSQL--VNC---SIQT 147
Query: 263 MRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCR--RFTDKGLQYLNLG 320
+ IS P +N+S + + L F N ++LS D L+ L +
Sbjct: 148 LGLISTAKPSF--MNVSESHFVS----ALTVVFINSKSLSSIKIEDTPVDDPSLKIL-VA 200
Query: 321 NGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITS 380
N L +S C +S G +A+ C G+ L +N LTD AL + +
Sbjct: 201 NNSDTLRLPKMSSCPHVSSDGILCVADRCQGLRELALN-YYILTDELFLALSSETH--VN 257
Query: 381 LVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLS---HIYMADCK 437
L +S+ +I+F K+ S+ + K+ P ++ H ++ + +
Sbjct: 258 LEHLRIDVVSE---------NPGQIKFHAVKK---HSWDALIKHSPRVNVVMHFFLYEEE 305
Query: 438 GITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNL-SNCVRLSDAS 496
++ + +P+ L + V +G +GL R+ EL + +N ++ D
Sbjct: 306 --FETFFKEETPVTHLYFGRSVSKVVLGRVGLN-------CPRLIELVVCANDLQPLDNE 356
Query: 497 VMKLSERCPNLNYLSLRNCE 516
++ ++E C NL L L CE
Sbjct: 357 LICIAEHCTNLTALGLSKCE 376
>gi|8923179 F-box and leucine-rich repeat protein 12 [Homo sapiens]
Length = 326
Score = 40.4 bits (93), Expect = 0.006
Identities = 40/163 (24%), Positives = 71/163 (43%), Gaps = 40/163 (24%)
Query: 487 SNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFS-LVSIDLSGTDIS-- 543
S +LS A + L ++CPNL R C H+ + I ++ S L +++L +IS
Sbjct: 84 SQAPQLSPALLRALGQKCPNLK----RLCLHVADLSMVPITSLPSTLRTLELHSCEISMA 139
Query: 544 --------------------------NEGLNVLSRHKKLKELSVSECYRITDDGIQITDS 577
+E L L+R + L+ L + YR+T+ G+ D+
Sbjct: 140 WLHKQQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGL---DA 196
Query: 578 AMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKM 620
++ LS YL L++ GC L D L + + +R +++
Sbjct: 197 GLQELS----YLQRLEVLGCTLSADSTLLAISRHLRDVRKIRL 235
Score = 38.9 bits (89), Expect = 0.016
Identities = 41/162 (25%), Positives = 70/162 (43%), Gaps = 30/162 (18%)
Query: 158 LPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQ 217
LP+ +L+IF YL ++D I +V H W + LW +D + + K + L+
Sbjct: 7 LPDSVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLTLY--TMRPKVMWHLLR 64
Query: 218 RW---RLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCPGV- 273
R+ RL+ LR+ G L + S P + +R + + CP +
Sbjct: 65 RYMASRLHSLRMG--GYL-----------------FSGSQAPQLSPALLRALGQKCPNLK 105
Query: 274 -LCL---NLSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFTD 311
LCL +LS IT+ L H+ + +S+A+ + D
Sbjct: 106 RLCLHVADLSMVPITSLPSTLRTLELHSCE-ISMAWLHKQQD 146
>gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 family,
member E isoform 1 [Homo sapiens]
Length = 268
Score = 39.7 bits (91), Expect = 0.009
Identities = 28/94 (29%), Positives = 49/94 (52%), Gaps = 8/94 (8%)
Query: 451 KQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYL 510
K+L L++AN + L P+ ++R+L LS+ + V L+E+CPNL YL
Sbjct: 42 KELEFLSMAN------VELSSLARLPSLNKLRKLELSDNIISGGLEV--LAEKCPNLTYL 93
Query: 511 SLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISN 544
+L + + + N+ +L S+DL +I+N
Sbjct: 94 NLSGNKIKDLSTVEALQNLKNLKSLDLFNCEITN 127
Score = 30.8 bits (68), Expect = 4.4
Identities = 20/67 (29%), Positives = 34/67 (50%), Gaps = 2/67 (2%)
Query: 395 RALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLT 454
R S KLRK+ N + + + + PNL+++ ++ K S++ +L LK L
Sbjct: 59 RLPSLNKLRKLELSDN--IISGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLK 116
Query: 455 VLNLANC 461
L+L NC
Sbjct: 117 SLDLFNC 123
>gi|210147571 acidic (leucine-rich) nuclear phosphoprotein 32
family, member E isoform 3 [Homo sapiens]
Length = 220
Score = 37.7 bits (86), Expect = 0.036
Identities = 22/69 (31%), Positives = 39/69 (56%), Gaps = 2/69 (2%)
Query: 476 PASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSI 535
P+ ++R+L LS+ + V L+E+CPNL YL+L + + + N+ +L S+
Sbjct: 13 PSLNKLRKLELSDNIISGGLEV--LAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSL 70
Query: 536 DLSGTDISN 544
DL +I+N
Sbjct: 71 DLFNCEITN 79
Score = 30.8 bits (68), Expect = 4.4
Identities = 20/67 (29%), Positives = 34/67 (50%), Gaps = 2/67 (2%)
Query: 395 RALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLT 454
R S KLRK+ N + + + + PNL+++ ++ K S++ +L LK L
Sbjct: 11 RLPSLNKLRKLELSDN--IISGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLK 68
Query: 455 VLNLANC 461
L+L NC
Sbjct: 69 SLDLFNC 75
>gi|33589814 zyg-11 homolog B (C. elegans)-like [Homo sapiens]
Length = 766
Score = 37.7 bits (86), Expect = 0.036
Identities = 46/203 (22%), Positives = 87/203 (42%), Gaps = 17/203 (8%)
Query: 413 VTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTV-LNLANCVRI------- 464
V D + I K +L +Y+ +C+ ++ SL++L V L+L C I
Sbjct: 92 VQDQDLEAIRKQ--DLVELYLTNCEKLSAKSLQTLRSFSHTLVSLSLFGCTNIFYEEENP 149
Query: 465 GDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLS-LRNCEHLTAQGI 523
G + ++ + +++ RL ++ ++ + P + L L + L GI
Sbjct: 150 GGCEDEYLVNPTCQVLVKDFTFEGFSRLRFLNLGRMIDWVPVESLLRPLNSLAALDLSGI 209
Query: 524 GYIVNIF------SLVSIDLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQITDS 577
F SLVS+ L D+S++ + V+ + KL+ L +S + ++T
Sbjct: 210 QTSDAAFLTQWKDSLVSLVLYNMDLSDDHIRVIVQLHKLRHLDISRDRLSSYYKFKLTRE 269
Query: 578 AMEMLSAKCHYLHILDISGCVLL 600
+ + K L LDISG ++L
Sbjct: 270 VLSLFVQKLGNLMSLDISGHMIL 292
>gi|16306584 F-box and leucine-rich repeat protein 3 [Homo sapiens]
Length = 428
Score = 37.4 bits (85), Expect = 0.047
Identities = 59/261 (22%), Positives = 96/261 (36%), Gaps = 48/261 (18%)
Query: 131 AEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQ 190
+ E E+S + + CD L + ILQ+F YL L D QV W +
Sbjct: 12 SSEEGTAEKSKKLRTTNEHSQTCDWGNLLQDIILQVFKYLPLLDRAHASQVCRNWNQVFH 71
Query: 191 LNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRSV--SHCRNLQ 248
+ LW +F N Y+ +T P+ + + H +LQ
Sbjct: 72 MPDLWRCFEFE--LNQPATSYLKAT------------------HPELIKQIIKRHSNHLQ 111
Query: 249 ELNVSDCPTFTDESMRHISEGCPGVL--CLNLSNTTI----TNRT--MRLLPRHFHNLQN 300
+ +F +S + +E +L +N S T+ T R M L HF +
Sbjct: 112 YV------SFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALT 165
Query: 301 LSLAYCRRFT----------DKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCT 350
+ + + D L+ L + N L L +S C +S G +A+ C
Sbjct: 166 VVFVNSKSLSSLKIDDTPVDDPSLKVL-VANNSDTLKLLKMSSCPHVSPAGILCVADQCH 224
Query: 351 GIMHLTINDMPTLTDNCVKAL 371
G+ L +N L+D + AL
Sbjct: 225 GLRELALN-YHLLSDELLLAL 244
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,168,571
Number of Sequences: 37866
Number of extensions: 998616
Number of successful extensions: 2946
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 2333
Number of HSP's gapped (non-prelim): 234
length of query: 690
length of database: 18,247,518
effective HSP length: 109
effective length of query: 581
effective length of database: 14,120,124
effective search space: 8203792044
effective search space used: 8203792044
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.