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Search of human proteins with 158937242
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|158937242 cytochrome P450, family 4, subfamily A,
polypeptide 11 [Homo sapiens]
(519 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide... 1066 0.0
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ... 1006 0.0
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide... 529 e-150
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide... 527 e-150
gi|30023836 cytochrome P450 4Z1 [Homo sapiens] 525 e-149
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ... 501 e-142
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide... 424 e-118
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ... 423 e-118
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8... 415 e-116
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11... 411 e-115
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11... 411 e-115
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide... 410 e-114
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide... 408 e-114
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide... 252 7e-67
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 150 3e-36
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 145 1e-34
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 144 1e-34
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 144 3e-34
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 140 3e-33
gi|239757171 PREDICTED: similar to cytochrome P450, family 4, su... 115 1e-25
gi|239751683 PREDICTED: similar to cytochrome P450, family 4, su... 115 1e-25
gi|239746187 PREDICTED: similar to cytochrome P450, family 4, su... 115 1e-25
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ... 111 1e-24
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ... 111 1e-24
gi|5729796 cytochrome P450, family 46 [Homo sapiens] 111 1e-24
gi|16933528 cytochrome P450, family 26, subfamily A, polypeptide... 110 4e-24
gi|16933530 cytochrome P450, family 26, subfamily A, polypeptide... 110 4e-24
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ... 104 2e-22
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H... 103 4e-22
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H... 103 4e-22
>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
[Homo sapiens]
Length = 519
Score = 1066 bits (2758), Expect = 0.0
Identities = 519/519 (100%), Positives = 519/519 (100%)
Query: 1 MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLF 60
MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLF
Sbjct: 1 MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLF 60
Query: 61 GHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSY 120
GHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSY
Sbjct: 61 GHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSY 120
Query: 121 RFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQD 180
RFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQD
Sbjct: 121 RFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQD 180
Query: 181 SPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQND 240
SPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQND
Sbjct: 181 SPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQND 240
Query: 241 TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM 300
TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM
Sbjct: 241 TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM 300
Query: 301 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGAS 360
ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGAS
Sbjct: 301 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGAS 360
Query: 361 ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH 420
ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH
Sbjct: 361 ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH 420
Query: 421 NPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFEL 480
NPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFEL
Sbjct: 421 NPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFEL 480
Query: 481 LPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL 519
LPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL
Sbjct: 481 LPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL 519
>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
[Homo sapiens]
Length = 519
Score = 1006 bits (2600), Expect = 0.0
Identities = 492/519 (94%), Positives = 502/519 (96%)
Query: 1 MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLF 60
MSVSVLSPSR LG VSGILQ SLLILLLLLIKA QLYLHRQWLLKALQQFPCPPSHWLF
Sbjct: 1 MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLF 60
Query: 61 GHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSY 120
GHIQE Q DQELQRIQ+ V+TFPSACP+W+WGGKVRVQLYDPDYMKVILGRSDPKSHGSY
Sbjct: 61 GHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSY 120
Query: 121 RFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQD 180
+FLAP IGYGLLLLNGQTWFQHRRMLTPAFH DILKPYVGLMADSVRVMLDKWEELLGQD
Sbjct: 121 KFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQD 180
Query: 181 SPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQND 240
SPLEVFQHVSLMTLDTIMK AFSHQGSIQVDRNSQSYIQAISDLN+LVF +RNAFH+ND
Sbjct: 181 SPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHEND 240
Query: 241 TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM 300
TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM
Sbjct: 241 TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM 300
Query: 301 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGAS 360
ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIH LLGDGAS
Sbjct: 301 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGAS 360
Query: 361 ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH 420
ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH
Sbjct: 361 ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH 420
Query: 421 NPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFEL 480
NPKVWPN EVFDP RFAPGSAQHSHAFLPFSGGSRNCIGKQFAMN+LKVA ALTLLRFEL
Sbjct: 421 NPKVWPNLEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFEL 480
Query: 481 LPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL 519
LPDPTRIPIP+ARLVLKSKNGIHLRLRRLPNPCEDKDQL
Sbjct: 481 LPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL 519
>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
isoform b [Homo sapiens]
Length = 511
Score = 529 bits (1363), Expect = e-150
Identities = 267/504 (52%), Positives = 336/504 (66%), Gaps = 3/504 (0%)
Query: 8 PSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQ 67
PS L S + AS LIL+L +K + L L RQ L KA+ +FP PP+HWLFGH E+Q
Sbjct: 3 PSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQ 62
Query: 68 QDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWI 127
+ L ++ W FP A P W + +Y+PDY K + R DPK+ Y F WI
Sbjct: 63 ETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWI 122
Query: 128 GYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQ 187
G GLL+L G W QHR++LTP FHYD+LKPYV + +S R+MLDKWEE + ++F
Sbjct: 123 GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFC 182
Query: 188 HVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTS 247
V M L+T+MKC F +G + SY A+SDL L+ R+ + + ND IY LT
Sbjct: 183 DVGHMALNTLMKCTFG-RGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTP 241
Query: 248 AGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILS 307
GR RACQ+AH HTDQVI+ RKA LQ E +KI+ +RHLDFLDILL A+ E+ LS
Sbjct: 242 HGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLS 301
Query: 308 DKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLD 367
D DLRAEVDTFMFEGHDTT SGISW LY +A +P+HQ RCREE+ +LGD W+ L
Sbjct: 302 DADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLG 361
Query: 368 QMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPN 427
+M Y TMCIKE+ RLYPPVP + R+LS PVTF DGRSLP G ++ + IY LH N VWP+
Sbjct: 362 KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPD 421
Query: 428 PEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPT 485
PEVFD RF+ S +H AF+PFS G RNCIG+QFAM+E+KV TA+ LLRFE DP+
Sbjct: 422 PEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPS 481
Query: 486 RIPIPIARLVLKSKNGIHLRLRRL 509
R+PI + +LVL+SKNG HL L+ L
Sbjct: 482 RLPIKMPQLVLRSKNGFHLHLKPL 505
>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
isoform a [Homo sapiens]
Length = 512
Score = 527 bits (1358), Expect = e-150
Identities = 266/504 (52%), Positives = 334/504 (66%), Gaps = 2/504 (0%)
Query: 8 PSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQ 67
PS L S + AS LIL+L +K + L L RQ L KA+ +FP PP+HWLFGH E+Q
Sbjct: 3 PSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQ 62
Query: 68 QDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWI 127
+ L ++ W FP A P W + +Y+PDY K + R DPK+ Y F WI
Sbjct: 63 ETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWI 122
Query: 128 GYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQ 187
G GLL+L G W QHR++LTP FHYD+LKPYV + +S R+MLDKWEE + ++F
Sbjct: 123 GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFC 182
Query: 188 HVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTS 247
V M L+T+MKC F + SY A+SDL L+ R+ + + ND IY LT
Sbjct: 183 DVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTP 242
Query: 248 AGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILS 307
GR RACQ+AH HTDQVI+ RKA LQ E +KI+ +RHLDFLDILL A+ E+ LS
Sbjct: 243 HGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLS 302
Query: 308 DKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLD 367
D DLRAEVDTFMFEGHDTT SGISW LY +A +P+HQ RCREE+ +LGD W+ L
Sbjct: 303 DADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLG 362
Query: 368 QMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPN 427
+M Y TMCIKE+ RLYPPVP + R+LS PVTF DGRSLP G ++ + IY LH N VWP+
Sbjct: 363 KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPD 422
Query: 428 PEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPT 485
PEVFD RF+ S +H AF+PFS G RNCIG+QFAM+E+KV TA+ LLRFE DP+
Sbjct: 423 PEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPS 482
Query: 486 RIPIPIARLVLKSKNGIHLRLRRL 509
R+PI + +LVL+SKNG HL L+ L
Sbjct: 483 RLPIKMPQLVLRSKNGFHLHLKPL 506
>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
Length = 505
Score = 525 bits (1352), Expect = e-149
Identities = 256/488 (52%), Positives = 348/488 (71%), Gaps = 4/488 (0%)
Query: 24 LLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRIQKWVETFP 83
LL + LLL + ++LY R+W+++AL FP PP+HW +GH +E +E + K +E +P
Sbjct: 19 LLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGH-KEFYPVKEFEVYHKLMEKYP 77
Query: 84 SACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHR 143
A P W+ + ++DPDY K++L R DPKS S++ L W+G GL+ L+G W +HR
Sbjct: 78 CAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHR 137
Query: 144 RMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFS 203
+++ P F+ ILK ++ +M++SVR+ML+KWEE + Q+S LE+FQHVSLMTLD+IMKCAFS
Sbjct: 138 QIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFS 197
Query: 204 HQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHT 263
HQGSIQ+D SY++A+ +L+ + R+ N H ND ++ +S G+ + Q HQ T
Sbjct: 198 HQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFT 257
Query: 264 DQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGH 323
++VIQ RK L K+ + +KR DFLDILL AK EN S+ DL+AEV TFMF GH
Sbjct: 258 EKVIQDRKESL-KDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGH 316
Query: 324 DTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLY 383
DTT+S ISWILY LA +P+HQ+RCR+EI LLGDG+SITW HL QMPYTTMCIKE LRLY
Sbjct: 317 DTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQMPYTTMCIKECLRLY 376
Query: 384 PPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQ- 442
PV I R L P+TFPDGRSLP GI V ++I+ LHHNP W +P+VF+P RF+ +++
Sbjct: 377 APVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEK 436
Query: 443 -HSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNG 501
H +AF+PFS G RNCIG+ FA+ E KVA ALTLLRF+L PD +R P P+ ++VLKSKNG
Sbjct: 437 IHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNG 496
Query: 502 IHLRLRRL 509
IH+ +++
Sbjct: 497 IHVFAKKV 504
>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
[Homo sapiens]
Length = 509
Score = 501 bits (1290), Expect = e-142
Identities = 243/491 (49%), Positives = 343/491 (69%), Gaps = 4/491 (0%)
Query: 22 ASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRIQKWVET 81
A + L L L++A++LYL RQ LL+ L+ FP PP+HW GH Q+ QD ++++++ +E
Sbjct: 17 AFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGH-QKFIQDDNMEKLEEIIEK 75
Query: 82 FPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQ 141
+P A P W+ + +YDPDY K +L R+DPKS +F P +G GL L+G WFQ
Sbjct: 76 YPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQ 135
Query: 142 HRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLG-QDSPLEVFQHVSLMTLDTIMKC 200
HRR+LTP FH++ILK Y+ +MA SV++MLDKWE++ QD+ +EV++H++ M+LD IMKC
Sbjct: 136 HRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKC 195
Query: 201 AFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAH 260
AFS + + Q + Y +AI +L+ ++F R+ + + +D I+ L+ G + ++ +
Sbjct: 196 AFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLN 255
Query: 261 QHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMF 320
Q+TD +IQ RK LQ + + ++++ DFLDI+L AK E+GS SD D+ +EV TF+
Sbjct: 256 QYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLL 315
Query: 321 EGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEAL 380
GHDT A+ ISWILY LA +P+HQERCREE+ +LGDG+SITW+ L +M YTTMCIKE
Sbjct: 316 AGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETC 375
Query: 381 RLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGS 440
RL P VP I R+LS P+TFPDG +LP GI V+LSI+GLHHNP VW NP+VFDP RF+ +
Sbjct: 376 RLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQEN 435
Query: 441 A--QHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKS 498
+ +H +A+LPFS GSRNCIG++FAM ELKV AL LL F + PDPTR +LK
Sbjct: 436 SDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKP 495
Query: 499 KNGIHLRLRRL 509
KNG++L L++L
Sbjct: 496 KNGMYLHLKKL 506
>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
[Homo sapiens]
Length = 520
Score = 424 bits (1090), Expect = e-118
Identities = 235/508 (46%), Positives = 315/508 (62%), Gaps = 22/508 (4%)
Query: 21 AASLLILLLLLIKAVQLYLHRQWLLK------ALQQFPCPPS-HWLFGHIQELQQDQE-L 72
AAS +LLLL+ + L W L+ FP PP +W GH+ + +E L
Sbjct: 15 AASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHLGLIHSSEEGL 74
Query: 73 QRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVIL---GRSDPKSHGSYRFLAPWIGY 129
Q TF C W+ V+++ P Y+K +L PK Y FL PW+G
Sbjct: 75 LYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGD 134
Query: 130 GLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSP-LEVFQH 188
GLLL G+ W +HRRMLTPAFH++ILKPY+ + +SV +M KW+ L + S L++F+H
Sbjct: 135 GLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEH 194
Query: 189 VSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSA 248
+SLMTLD++ KC FS Q YI AI +L+ LV R + D +Y LT
Sbjct: 195 ISLMTLDSLQKCVFSFDSHCQ--EKPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPD 252
Query: 249 GRWTHRACQLAHQHTDQVIQLRKAQLQKEGE---LEKIKRKRHLDFLDILLLAKMENGSI 305
G+ RAC+L H TD VIQ R+ L +G L+ + + LDF+D+LLL+K E+G
Sbjct: 253 GQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKK 312
Query: 306 LSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGA--SITW 363
LSD+D+RAE DTFMFEGHDTTASG+SW+LY LA HP++QERCR+E+ LL D I W
Sbjct: 313 LSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEW 372
Query: 364 NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPK 423
+ L Q+P+ TMCIKE+LRL+PPVP + R + + PDGR +PKGI+ L+S++G HHNP
Sbjct: 373 DDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPA 432
Query: 424 VWPNPEVFDPFRFAPGSAQHSH--AFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELL 481
VWP+PEV+DPFRF P + + AF+PFS G RNCIG+ FAM E+KV LTLLRF +L
Sbjct: 433 VWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVL 492
Query: 482 PDPTRIPIPIARLVLKSKNGIHLRLRRL 509
PD T P LVL+++ G+ LR+ L
Sbjct: 493 PDHTE-PRRKPELVLRAEGGLWLRVEPL 519
>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
[Homo sapiens]
Length = 520
Score = 423 bits (1088), Expect = e-118
Identities = 235/513 (45%), Positives = 318/513 (61%), Gaps = 23/513 (4%)
Query: 17 GILQAASLLILLLLLIKAVQLYLH-RQWLL------KALQQFPCPPS-HWLFGHIQELQQ 68
G+ A+ LLLLL+ A L H W + L+ FP PP +W +GH +
Sbjct: 10 GLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNP 69
Query: 69 DQELQRI-QKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSD---PKSHGSYRFLA 124
+E R+ + V T+P W+ + L PD ++ ++ S PK Y FL
Sbjct: 70 TEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLE 129
Query: 125 PWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSP-L 183
PW+G GLLL G W +HRRMLTPAFH++ILKPY+ + +SV +M KW+ L + S L
Sbjct: 130 PWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACL 189
Query: 184 EVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIY 243
++F+H+SLMTLD++ KC FS Q YI AI +L+ LV R D +Y
Sbjct: 190 DMFEHISLMTLDSLQKCVFSFDSHCQ--EKPSEYIAAILELSALVSKRHHEILLHIDFLY 247
Query: 244 SLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGE---LEKIKRKRHLDFLDILLLAKM 300
LT G+ RAC+L H TD VIQ R+ L +G L+ + + LDF+D+LLL+K
Sbjct: 248 YLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKD 307
Query: 301 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGA- 359
E+G LSD+D+RAE DTFMFEGHDTTASG+SW+LY LA HP++QERCR+E+ LL D
Sbjct: 308 EDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREP 367
Query: 360 -SITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGL 418
I W+ L +P+ TMC+KE+LRL+PPVP I R ++ + PDGR +PKGI+ L+S++G
Sbjct: 368 KEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGT 427
Query: 419 HHNPKVWPNPEVFDPFRFAPGSAQHSH--AFLPFSGGSRNCIGKQFAMNELKVATALTLL 476
HHNP VWP+PEV+DPFRF P + + AF+PFS G RNCIG+ FAM E+KV ALTLL
Sbjct: 428 HHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLL 487
Query: 477 RFELLPDPTRIPIPIARLVLKSKNGIHLRLRRL 509
RF +LPD T P LVL+++ G+ LR+ L
Sbjct: 488 RFRVLPDHTE-PRRKPELVLRAEGGLWLRVEPL 519
>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
[Homo sapiens]
Length = 520
Score = 415 bits (1066), Expect = e-116
Identities = 220/477 (46%), Positives = 303/477 (63%), Gaps = 16/477 (3%)
Query: 46 KALQQFPCP-PSHWLFGHIQELQQDQE-LQRIQKWVETFPSACPHWLWGGKVRVQLYDPD 103
+ L+ FP P +W GH+ + +E L+ + + V T+P WL + L PD
Sbjct: 46 RRLRCFPQPRKQNWFLGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPD 105
Query: 104 YMKVILGRSDP---KSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVG 160
++ ++ SD K Y+ L PW+G GLLL G W HRR+LTPAFH++ILKPY+
Sbjct: 106 IVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIK 165
Query: 161 LMADSVRVMLDKWEELLGQDSP-LEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQ 219
+ + S +M KW+ L + S L+VF+H+SLMTLD++ KC FS + Q YI
Sbjct: 166 IFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQ--EKPSEYIT 223
Query: 220 AISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGE 279
AI +L+ LV R F D +Y LT GR HRAC+L H TD VIQ R+ L +G
Sbjct: 224 AIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGV 283
Query: 280 ---LEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYA 336
L+ + + LDF+D+LLL++ +NG LSD+D+RAE DTFMF GHDTTASG+SW+LY
Sbjct: 284 DDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYN 343
Query: 337 LATHPKHQERCREEIHSLLGD--GASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELS 394
LA HP++QERCR+E+ LL D I W+ L Q+P+ TMC+KE+LRL+PP+P R +
Sbjct: 344 LARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCT 403
Query: 395 TPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSH--AFLPFSG 452
V PD R +PKG + ++I+ +HHNP VWP+PEV+DPFRF P +AQ AF+PFS
Sbjct: 404 QDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSA 463
Query: 453 GSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRLRRL 509
G RNCIG++FAM E+KV ALTLLRF +LPD R P +VL++++G+ LR+ L
Sbjct: 464 GPRNCIGQKFAMAEMKVVLALTLLRFRILPD-HREPRRTPEIVLRAEDGLWLRVEPL 519
>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 411 bits (1056), Expect = e-115
Identities = 232/508 (45%), Positives = 314/508 (61%), Gaps = 22/508 (4%)
Query: 21 AASLLILLLLLIKAVQLYLHRQWLL------KALQQFPCPPS-HWLFGHIQELQQDQE-L 72
AAS +LLLL+ + L W + LQ FP PP +W +GH + +E +
Sbjct: 15 AASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQGLVTPTEEGM 74
Query: 73 QRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSD---PKSHGSYRFLAPWIGY 129
+ + + V T+P WL + L PD ++ I S PK Y FL PW+G
Sbjct: 75 KTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGD 134
Query: 130 GLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSP-LEVFQH 188
GLLL G W +HRRMLTPAFH++ILKPY+ + SV +M DKW+ L + S L++F+H
Sbjct: 135 GLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEH 194
Query: 189 VSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSA 248
+SLMTLD++ KC FS + + Q YI AI +L+ V R + D +Y LT
Sbjct: 195 ISLMTLDSLQKCVFSFESNCQ--EKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPD 252
Query: 249 GRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRK---RHLDFLDILLLAKMENGSI 305
G+ RAC L H TD VIQ R+ L +G + +K K + LDF+D+LLL+K E+G
Sbjct: 253 GQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKE 312
Query: 306 LSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGD--GASITW 363
LSD+D+RAE DTFMFEGHDTTASG+SW+LY LA HP++QE+CR+E+ LL D I W
Sbjct: 313 LSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEW 372
Query: 364 NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPK 423
+ L Q+P+ TMCIKE+LRL+PPVP I R + PDGR +PKGI+ L++I G+H+NP
Sbjct: 373 DDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPT 432
Query: 424 VWPNPEVFDPFRFAPGSAQHSH--AFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELL 481
VWP+PEV+DPFRF + + AF+PFS G RNCIG+ FAM E+KV ALTLL F +L
Sbjct: 433 VWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRIL 492
Query: 482 PDPTRIPIPIARLVLKSKNGIHLRLRRL 509
P T P L+L+++ G+ LR+ L
Sbjct: 493 PTHTE-PRRKPELILRAEGGLWLRVEPL 519
>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 411 bits (1056), Expect = e-115
Identities = 232/508 (45%), Positives = 314/508 (61%), Gaps = 22/508 (4%)
Query: 21 AASLLILLLLLIKAVQLYLHRQWLL------KALQQFPCPPS-HWLFGHIQELQQDQE-L 72
AAS +LLLL+ + L W + LQ FP PP +W +GH + +E +
Sbjct: 15 AASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQGLVTPTEEGM 74
Query: 73 QRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSD---PKSHGSYRFLAPWIGY 129
+ + + V T+P WL + L PD ++ I S PK Y FL PW+G
Sbjct: 75 KTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGD 134
Query: 130 GLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSP-LEVFQH 188
GLLL G W +HRRMLTPAFH++ILKPY+ + SV +M DKW+ L + S L++F+H
Sbjct: 135 GLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEH 194
Query: 189 VSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSA 248
+SLMTLD++ KC FS + + Q YI AI +L+ V R + D +Y LT
Sbjct: 195 ISLMTLDSLQKCVFSFESNCQ--EKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPD 252
Query: 249 GRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRK---RHLDFLDILLLAKMENGSI 305
G+ RAC L H TD VIQ R+ L +G + +K K + LDF+D+LLL+K E+G
Sbjct: 253 GQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKE 312
Query: 306 LSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGD--GASITW 363
LSD+D+RAE DTFMFEGHDTTASG+SW+LY LA HP++QE+CR+E+ LL D I W
Sbjct: 313 LSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEW 372
Query: 364 NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPK 423
+ L Q+P+ TMCIKE+LRL+PPVP I R + PDGR +PKGI+ L++I G+H+NP
Sbjct: 373 DDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPT 432
Query: 424 VWPNPEVFDPFRFAPGSAQHSH--AFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELL 481
VWP+PEV+DPFRF + + AF+PFS G RNCIG+ FAM E+KV ALTLL F +L
Sbjct: 433 VWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRIL 492
Query: 482 PDPTRIPIPIARLVLKSKNGIHLRLRRL 509
P T P L+L+++ G+ LR+ L
Sbjct: 493 PTHTE-PRRKPELILRAEGGLWLRVEPL 519
>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
[Homo sapiens]
Length = 531
Score = 410 bits (1053), Expect = e-114
Identities = 223/499 (44%), Positives = 312/499 (62%), Gaps = 14/499 (2%)
Query: 24 LLILLLLLIKAVQLYLHRQWLLKALQQFPCPPS-HWLFGHI-QELQQDQELQRIQKWVET 81
L L LL++ ++L + L+ FP PP +WL GH+ L + LQ +K ++
Sbjct: 32 LFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGLQDEKKVLDN 91
Query: 82 FPSACPHWLWGGKVRVQLYDPDYMKVILGRSD---PKSHGSYRFLAPWIGYGLLLLNGQT 138
W+ + L PDY+K +LG S PK Y FL PW+G GLLL G
Sbjct: 92 MHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDK 151
Query: 139 WFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELL-GQDSPLEVFQHVSLMTLDTI 197
W +HRR+LTPAFH+DILKPY+ + S +M KW L G L++F+H+SLMTLD++
Sbjct: 152 WSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSL 211
Query: 198 MKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQ 257
KC FS+ + Q YI AI +L+ L R H D IY ++ GR +AC
Sbjct: 212 QKCVFSYNSNCQ--EKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACD 269
Query: 258 LAHQHTDQVIQLRKAQLQKEGELEKIKRK--RHLDFLDILLLAKMENGSILSDKDLRAEV 315
+ H T +VIQ R+ L+++G +K K + LDF+D+LLLA+ E+G LSD+D+RAE
Sbjct: 270 MVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEA 329
Query: 316 DTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLG--DGASITWNHLDQMPYTT 373
DTFMFEGHDTT+SGISW+L+ LA +P++QE+CREEI ++ + + W+ L Q+P+TT
Sbjct: 330 DTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTT 389
Query: 374 MCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDP 433
MCIKE+LR YPPV + R+ + + PDGR +PKGI+ L+SIYG HHNP VWP+ +V++P
Sbjct: 390 MCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNP 449
Query: 434 FRFAPGSAQHSH--AFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPI 491
+RF P + Q A++PFS G RNCIG+ FAM EL+V ALTLLRF L D TR
Sbjct: 450 YRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRK 509
Query: 492 ARLVLKSKNGIHLRLRRLP 510
L+L+++NG+ L++ LP
Sbjct: 510 PELILRTENGLWLKVEPLP 528
>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
[Homo sapiens]
Length = 524
Score = 408 bits (1049), Expect = e-114
Identities = 229/508 (45%), Positives = 314/508 (61%), Gaps = 22/508 (4%)
Query: 21 AASLLILLLLLIKAVQLYLHRQWLL------KALQQFPCPPS-HWLFGHIQELQQDQE-L 72
A S +LLLL++ + L W + LQ FP PP +W +GH+ + +E L
Sbjct: 15 AMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGL 74
Query: 73 QRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSD---PKSHGSYRFLAPWIGY 129
+ + T+ WL + L PD ++ I S PK + RFL PW+G
Sbjct: 75 KDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGE 134
Query: 130 GLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSP-LEVFQH 188
G+LL G W +HRRMLTPAFH++ILK Y+ + S +MLDKW+ L + S L++F+H
Sbjct: 135 GILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEH 194
Query: 189 VSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSA 248
+SLMTLD++ KC FS Q +R S+ YI I +L+ LV R ++ D +Y L+
Sbjct: 195 ISLMTLDSLQKCIFSFDSHCQ-ERPSE-YIATILELSALVEKRSQHILQHMDFLYYLSHD 252
Query: 249 GRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRK---RHLDFLDILLLAKMENGSI 305
GR HRAC+L H TD VI+ R+ L +G + K K + LDF+D+LLL+K E+G
Sbjct: 253 GRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKA 312
Query: 306 LSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDG--ASITW 363
LSD+D+RAE DTFMF GHDTTASG+SW+LY LA HP++QERCR+E+ LL D I W
Sbjct: 313 LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEW 372
Query: 364 NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPK 423
+ L Q+P+ TMC+KE+LRL+PP P I R + + PDGR +PKGI L+ I G+HHNP
Sbjct: 373 DDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPT 432
Query: 424 VWPNPEVFDPFRFAPGSAQHSH--AFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELL 481
VWP+PEV+DPFRF P +++ AF+PFS G RNCIG+ FAM E+KV AL LL F L
Sbjct: 433 VWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFL 492
Query: 482 PDPTRIPIPIARLVLKSKNGIHLRLRRL 509
PD T P L+++++ G+ LR+ L
Sbjct: 493 PDHTE-PRRKLELIMRAEGGLWLRVEPL 519
>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
[Homo sapiens]
Length = 525
Score = 252 bits (643), Expect = 7e-67
Identities = 173/516 (33%), Positives = 275/516 (53%), Gaps = 29/516 (5%)
Query: 11 LLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPP---SHWLFGHIQELQ 67
L G S + A + L+L LL + V Y R+W Q P P ++ L GH ++
Sbjct: 15 LWGAASALSLAGASLVLSLL--QRVASYA-RKWQ----QMRPIPTVARAYPLVGHALLMK 67
Query: 68 QD--QELQRIQKWVETFPSACPHWLWGGKV-RVQLYDPDYMKVILGRSDPKSHGS-YRFL 123
D + Q+I ++ E + LW G V V LY+ + ++VIL S S Y+FL
Sbjct: 68 PDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFL 127
Query: 124 APWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPL 183
PW+G GLL G W R+MLTP FH+ IL+ ++ +M + +++ K E+ + Q++
Sbjct: 128 EPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEA-F 186
Query: 184 EVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIY 243
F +++L LD I + A Q + +S+ Y++A+ ++ ++F R++ + D Y
Sbjct: 187 NCFFYITLCALDIICETAMGKNIGAQSNDDSE-YVRAVYRMSEMIFRRIKMPWLWLDLWY 245
Query: 244 SLTSAGRWTHR-ACQLAHQHTDQVIQLRKAQLQK------EGELEKIKRKRHLDFLDILL 296
+ G W H+ + Q+ H T+ VI R ++ +G + + FLD+LL
Sbjct: 246 LMFKEG-WEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLL 304
Query: 297 LAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLG 356
+ G+ LS +D+R EVDTFMFEGHDTTA+ I+W LY L ++P+ Q++ E+ + G
Sbjct: 305 SVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFG 364
Query: 357 -DGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSI 415
T L ++ Y IKE LRL+P VP R +S R L KG ++
Sbjct: 365 KSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVL-KGTEAVIIP 423
Query: 416 YGLHHNPKVWPNPEVFDPFRFAPGSAQ--HSHAFLPFSGGSRNCIGKQFAMNELKVATAL 473
Y LH +P+ +PNPE F P RF P +AQ H +A++PFS G RNCIG++FA+ E K +
Sbjct: 424 YALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSC 483
Query: 474 TLLRFELLPDPTRIPIPI-ARLVLKSKNGIHLRLRR 508
L F + + R + + +L+L+ NGI ++L+R
Sbjct: 484 ILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKR 519
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 150 bits (379), Expect = 3e-36
Identities = 132/484 (27%), Positives = 224/484 (46%), Gaps = 37/484 (7%)
Query: 28 LLLLIKAVQLYL---HRQWLLKALQQFPCPPSHWLFGHIQELQQ-----DQELQRIQKWV 79
LLL + V LYL H L K L P P G+I + D E + V
Sbjct: 13 LLLAVSLVLLYLYGTHSHGLFKKLG-IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKV 71
Query: 80 ETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWIGY---GLLLLNG 136
F G + + + DPD +K +L + + R P +G+ + +
Sbjct: 72 WGFYD-------GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGP-VGFMKSAISIAED 123
Query: 137 QTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDT 196
+ W + R +L+P F LK V ++A V++ P+ + ++D
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 197 IMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRAC 256
I +F + +D + + + L+ + F + T++ C
Sbjct: 184 ITSTSFG----VNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNIC 239
Query: 257 QLAHQHTDQVIQLRKA-QLQKEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDL 311
+ T+ LRK+ + KE LE ++ R +DFL +++ ++ E+ LSD +L
Sbjct: 240 VFPREVTNF---LRKSVKRMKESRLEDTQKHR-VDFLQLMIDSQNSKETESHKALSDLEL 295
Query: 312 RAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPY 371
A+ F+F G++TT+S +S+I+Y LATHP Q++ +EEI ++L + A T++ + QM Y
Sbjct: 296 VAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEY 355
Query: 372 TTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVF 431
M + E LRL+P + R V +G +PKG++V++ Y LH +PK W PE F
Sbjct: 356 LDMVVNETLRLFPIAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYWTEPEKF 414
Query: 432 DPFRFAPGSAQH--SHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP-DPTRIP 488
P RF+ + + + + PF G RNCIG +FA+ +K+A L F P T+IP
Sbjct: 415 LPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
Query: 489 IPIA 492
+ ++
Sbjct: 475 LKLS 478
>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
[Homo sapiens]
Length = 503
Score = 145 bits (365), Expect = 1e-34
Identities = 109/402 (27%), Positives = 196/402 (48%), Gaps = 21/402 (5%)
Query: 101 DPDYMKVILGRSDPKSHGSYRFLAPWIGY---GLLLLNGQTWFQHRRMLTPAFHYDILKP 157
DPD +K +L + + R P +G+ + + + W + R +L+P F LK
Sbjct: 86 DPDMIKTVLVKECYSVFTNRRPFGP-VGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKE 144
Query: 158 YVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSY 217
V ++A V++ P+ + ++D I +F + +D +
Sbjct: 145 MVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFG----VSIDSLNNPQ 200
Query: 218 IQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQ-K 276
+ + L+ + F + ++ + A + + L K+ Q K
Sbjct: 201 DPFVENTKKLLRFNPLDPFVLSIKVFPFLTP---ILEALNITVFPRKVISFLTKSVKQIK 257
Query: 277 EGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDLRAEVDTFMFEGHDTTASGISW 332
EG L++ ++ R +DFL +++ ++ E LSD +L A+ F+F G++TT+S +S+
Sbjct: 258 EGRLKETQKHR-VDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSF 316
Query: 333 ILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRE 392
I+Y LATHP Q++ ++EI ++L + A T++ + Q+ Y M + E LRL+P + R
Sbjct: 317 IIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERV 376
Query: 393 LSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQH--SHAFLPF 450
V +G +PKG++V++ Y LHH+PK W PE F P RF+ + + + + PF
Sbjct: 377 CKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPF 435
Query: 451 SGGSRNCIGKQFAMNELKVATALTLLRFELLP-DPTRIPIPI 491
G RNCIG +FA+ +K+A L F P T+IP+ +
Sbjct: 436 GSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKL 477
>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 2 [Homo sapiens]
Length = 503
Score = 144 bits (364), Expect = 1e-34
Identities = 109/432 (25%), Positives = 207/432 (47%), Gaps = 32/432 (7%)
Query: 92 GGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAP--WIGYGLLLLNGQTWFQHRRMLTPA 149
G + + + DPD +K +L + + L P ++ L + W + R +L+PA
Sbjct: 77 GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPA 136
Query: 150 FHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQ 209
F K V +++ +++ + + + T+D I F +
Sbjct: 137 FTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG----VN 192
Query: 210 VDRNSQSYIQAISDLNNLV-------FSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQH 262
+D + + ++ L+ F + + F ++ + G + + H
Sbjct: 193 LDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPK---DVTHFL 249
Query: 263 TDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDLRAEVDTF 318
+ + ++++++L K K+K +DF ++ ++ ++ LSD +L A+
Sbjct: 250 KNSIERMKESRL-------KDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIII 302
Query: 319 MFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKE 378
+F +DTT++ + +I+Y LATHP Q++ +EEI ++L + A +T++ L QM Y M + E
Sbjct: 303 IFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNE 362
Query: 379 ALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAP 438
LRL+P V + R + +G +PKG+ V++ IY LHH+PK W PE F P RF+
Sbjct: 363 TLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421
Query: 439 GSAQ--HSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP-DPTRIPIPIARL- 494
+ + ++PF G RNCIG +FA+ +K+A L F P T+IP+ + L
Sbjct: 422 KNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 481
Query: 495 VLKSKNGIHLRL 506
+L+ + I L++
Sbjct: 482 ILQPEKPIVLKV 493
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 144 bits (362), Expect = 3e-34
Identities = 128/478 (26%), Positives = 220/478 (46%), Gaps = 28/478 (5%)
Query: 28 LLLLIKAVQLYLH---RQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRIQKWVETFPS 84
LLL + V LYL+ L K L P P L G++ L Q L + E +
Sbjct: 13 LLLAVSLVLLYLYGTRTHGLFKRLG-IPGPTPLPLLGNV--LSYRQGLWKFD--TECYKK 67
Query: 85 ACPHW-LWGGKVRV-QLYDPDYMKVILGRSDPKSHGSYRFLAPWIGY---GLLLLNGQTW 139
W + G++ V + DPD ++ +L + + R L P +G+ + L + W
Sbjct: 68 YGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGP-VGFMKSAISLAEDEEW 126
Query: 140 FQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMK 199
+ R +L+P F LK ++A V++ + P+ + ++D I
Sbjct: 127 KRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITG 186
Query: 200 CAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLA 259
+F + +D + + + + + ++ + A ++
Sbjct: 187 TSFG----VNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTP---VFEALNVS 239
Query: 260 HQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDLRAEV 315
D + L K+ + + K+K LDFL +++ ++ E+ LSD +L A+
Sbjct: 240 LFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQS 299
Query: 316 DTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMC 375
F+F G++TT+S +S+ LY LATHP Q++ ++EI ++L + A T++ + QM Y M
Sbjct: 300 IIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMV 359
Query: 376 IKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFR 435
+ E LRL+P + R V +G +PKG MV++ Y LHH+PK W PE F P R
Sbjct: 360 VNETLRLFPVAIRLERTCKKDVEI-NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPER 418
Query: 436 FA-PGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP-DPTRIPIPI 491
F+ + + + PF G RNCIG +FA+ +K+A L F P T+IP+ +
Sbjct: 419 FSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL 476
>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 1 [Homo sapiens]
Length = 504
Score = 140 bits (353), Expect = 3e-33
Identities = 109/433 (25%), Positives = 207/433 (47%), Gaps = 33/433 (7%)
Query: 92 GGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAP--WIGYGLLLLNGQTWFQHRRMLTPA 149
G + + + DPD +K +L + + L P ++ L + W + R +L+PA
Sbjct: 77 GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPA 136
Query: 150 FHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQ 209
F K V +++ +++ + + + T+D I F +
Sbjct: 137 FTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG----VN 192
Query: 210 VDRNSQSYIQAISDLNNLV-------FSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQH 262
+D + + ++ L+ F + + F ++ + G + + H
Sbjct: 193 LDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPK---DVTHFL 249
Query: 263 TDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDLRAEVDTF 318
+ + ++++++L K K+K +DF ++ ++ ++ LSD +L A+
Sbjct: 250 KNSIERMKESRL-------KDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIII 302
Query: 319 MFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKE 378
+F +DTT++ + +I+Y LATHP Q++ +EEI ++L + A +T++ L QM Y M + E
Sbjct: 303 IFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNE 362
Query: 379 ALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDP-FRFA 437
LRL+P V + R + +G +PKG+ V++ IY LHH+PK W PE F P RF+
Sbjct: 363 TLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFS 421
Query: 438 PGSAQ--HSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP-DPTRIPIPIARL 494
+ + ++PF G RNCIG +FA+ +K+A L F P T+IP+ + L
Sbjct: 422 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 481
Query: 495 -VLKSKNGIHLRL 506
+L+ + I L++
Sbjct: 482 PILQPEKPIVLKV 494
>gi|239757171 PREDICTED: similar to cytochrome P450, family 4,
subfamily F, polypeptide 2 [Homo sapiens]
Length = 190
Score = 115 bits (288), Expect = 1e-25
Identities = 65/168 (38%), Positives = 100/168 (59%), Gaps = 7/168 (4%)
Query: 145 MLTPAFHYDILKPYVGLMADSVRVMLDKWEEL-LGQDSPLEVFQHVSLMTLDTIMKCAFS 203
ML PAFH++ILKPY+ + +SV +M KW L L ++ L++F+H++LMTLD++ KC FS
Sbjct: 1 MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60
Query: 204 HQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHT 263
Q YI ++ +L++LV R + D +Y LT GR HRAC+L H
Sbjct: 61 FDSQCQ--EKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFA 118
Query: 264 DQVIQLRKAQLQKEGE---LEKIKRKRHLDFLDILLLAK-MENGSILS 307
D IQ ++ L +G L+ + + LDF+D+LL++K M G ++S
Sbjct: 119 DAAIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLLISKAMTPGPVVS 166
>gi|239751683 PREDICTED: similar to cytochrome P450, family 4,
subfamily F, polypeptide 2 [Homo sapiens]
Length = 190
Score = 115 bits (288), Expect = 1e-25
Identities = 65/168 (38%), Positives = 100/168 (59%), Gaps = 7/168 (4%)
Query: 145 MLTPAFHYDILKPYVGLMADSVRVMLDKWEEL-LGQDSPLEVFQHVSLMTLDTIMKCAFS 203
ML PAFH++ILKPY+ + +SV +M KW L L ++ L++F+H++LMTLD++ KC FS
Sbjct: 1 MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60
Query: 204 HQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHT 263
Q YI ++ +L++LV R + D +Y LT GR HRAC+L H
Sbjct: 61 FDSQCQ--EKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFA 118
Query: 264 DQVIQLRKAQLQKEGE---LEKIKRKRHLDFLDILLLAK-MENGSILS 307
D IQ ++ L +G L+ + + LDF+D+LL++K M G ++S
Sbjct: 119 DAAIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLLISKAMTPGPVVS 166
>gi|239746187 PREDICTED: similar to cytochrome P450, family 4,
subfamily F, polypeptide 2 [Homo sapiens]
Length = 190
Score = 115 bits (288), Expect = 1e-25
Identities = 65/168 (38%), Positives = 100/168 (59%), Gaps = 7/168 (4%)
Query: 145 MLTPAFHYDILKPYVGLMADSVRVMLDKWEEL-LGQDSPLEVFQHVSLMTLDTIMKCAFS 203
ML PAFH++ILKPY+ + +SV +M KW L L ++ L++F+H++LMTLD++ KC FS
Sbjct: 1 MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60
Query: 204 HQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHT 263
Q YI ++ +L++LV R + D +Y LT GR HRAC+L H
Sbjct: 61 FDSQCQ--EKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFA 118
Query: 264 DQVIQLRKAQLQKEGE---LEKIKRKRHLDFLDILLLAK-MENGSILS 307
D IQ ++ L +G L+ + + LDF+D+LL++K M G ++S
Sbjct: 119 DAAIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLLISKAMTPGPVVS 166
>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
[Homo sapiens]
Length = 508
Score = 111 bits (278), Expect = 1e-24
Identities = 71/204 (34%), Positives = 102/204 (50%), Gaps = 5/204 (2%)
Query: 306 LSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASI--TW 363
L + + V + G DT ++ +SW LY L+ HP+ Q EI + L G+S +
Sbjct: 302 LPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSA 361
Query: 364 NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPK 423
L Q+P +KE LRLYP VPG R + D +PK +V L Y +P
Sbjct: 362 TVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGD-YIIPKNTLVTLCHYATSRDPA 420
Query: 424 VWPNPEVFDPFRF-APGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP 482
+P P F P R+ G H A LPF G R+C+G++ A EL++A A L FE+ P
Sbjct: 421 QFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP 480
Query: 483 DPTRIPI-PIARLVLKSKNGIHLR 505
+P P+ P R VL + I+L+
Sbjct: 481 EPGAAPVRPKTRTVLVPERSINLQ 504
>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 3 [Homo sapiens]
Length = 420
Score = 111 bits (278), Expect = 1e-24
Identities = 86/357 (24%), Positives = 167/357 (46%), Gaps = 28/357 (7%)
Query: 92 GGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAP--WIGYGLLLLNGQTWFQHRRMLTPA 149
G + + + DPD +K +L + + L P ++ L + W + R +L+PA
Sbjct: 77 GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPA 136
Query: 150 FHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQ 209
F K V +++ +++ + + + T+D I F +
Sbjct: 137 FTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG----VN 192
Query: 210 VDRNSQSYIQAISDLNNLV-------FSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQH 262
+D + + ++ L+ F + + F ++ + G + + H
Sbjct: 193 LDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPK---DVTHFL 249
Query: 263 TDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDLRAEVDTF 318
+ + ++++++L K K+K +DF ++ ++ ++ LSD +L A+
Sbjct: 250 KNSIERMKESRL-------KDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIII 302
Query: 319 MFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKE 378
+F +DTT++ + +I+Y LATHP Q++ +EEI ++L + A +T++ L QM Y M + E
Sbjct: 303 IFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNE 362
Query: 379 ALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFR 435
LRL+P V + R + +G +PKG+ V++ IY LHH+PK W PE F P R
Sbjct: 363 TLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
Length = 500
Score = 111 bits (278), Expect = 1e-24
Identities = 95/363 (26%), Positives = 163/363 (44%), Gaps = 28/363 (7%)
Query: 128 GYGLLL-LNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVF 186
G GL+ N + W + RR++ AF L + + +++ E +P+ +
Sbjct: 122 GQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQ 181
Query: 187 QHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLT 246
++ +D + K AF + S+ + A L+ V + +T+
Sbjct: 182 DMLTYTAMDILAKAAFGMETSM--------LLGAQKPLSQAVKLMLEGITASRNTLAKFL 233
Query: 247 SAGRWTHRACQLAHQHTDQV----IQLRKAQLQKEGELEKIKRKRHLDFLDILL-LAKME 301
R R + + + QV +Q R+ L++ E+ DIL + K E
Sbjct: 234 PGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPA----------DILTQILKAE 283
Query: 302 NGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASI 361
G+ D+ L TF GH+T+A+ +++ + L+ P+ R + E+ ++G +
Sbjct: 284 EGA-QDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYL 342
Query: 362 TWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHN 421
+ L ++ Y + +KE+LRLYPP G R L T DG +P +L S Y +
Sbjct: 343 DFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEE-TLIDGVRVPGNTPLLFSTYVMGRM 401
Query: 422 PKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATA--LTLLRFE 479
+ +P F+P RF PG+ + + PFS G R+CIG+QFA E+KV A L L F
Sbjct: 402 DTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR 461
Query: 480 LLP 482
L+P
Sbjct: 462 LVP 464
>gi|16933528 cytochrome P450, family 26, subfamily A, polypeptide 1
isoform 2 [Homo sapiens]
Length = 428
Score = 110 bits (274), Expect = 4e-24
Identities = 101/355 (28%), Positives = 165/355 (46%), Gaps = 28/355 (7%)
Query: 127 IGYGLLL-LNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEV 185
+G G L L+ + Q ++++ AF + L+ YV ++ + V L++W L + L V
Sbjct: 51 LGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQW--LSCGERGLLV 108
Query: 186 FQHVSLMTLDTIMKCAFSHQGSIQVDRNS-QSYIQAISDLNNLVFSRVRNAFHQNDTIYS 244
+ V + M+ + + D +S Q ++A ++ +FS D +S
Sbjct: 109 YPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSL------PIDVPFS 162
Query: 245 LTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGS 304
G +A L H +Q I+ + L+ + K D L +L+ E G
Sbjct: 163 GLYRGM---KARNLIHARIEQNIRAKICGLRASEAGQGCK-----DALQLLIEHSWERGE 214
Query: 305 ILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHS--LL---GDGA 359
L + L+ +F GH+TTAS + ++ L +P ++ REE+ S LL
Sbjct: 215 RLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDN 274
Query: 360 SITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLH 419
+ L+Q+ Y IKE LRL PPVPG G ++ +G +PKG V+ SI H
Sbjct: 275 KLDMEILEQLKYIGCVIKETLRLNPPVPG-GFRVALKTFELNGYQIPKGWNVIYSICDTH 333
Query: 420 HNPKVWPNPEVFDPFRFA---PGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVAT 471
+++ N E F+P RF P A +F+PF GG R+C+GK+FA LK+ T
Sbjct: 334 DVAEIFTNKEEFNPDRFMLPHPEDASR-FSFIPFGGGLRSCVGKEFAKILLKIFT 387
>gi|16933530 cytochrome P450, family 26, subfamily A, polypeptide 1
isoform 1 [Homo sapiens]
Length = 497
Score = 110 bits (274), Expect = 4e-24
Identities = 101/355 (28%), Positives = 165/355 (46%), Gaps = 28/355 (7%)
Query: 127 IGYGLLL-LNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEV 185
+G G L L+ + Q ++++ AF + L+ YV ++ + V L++W L + L V
Sbjct: 120 LGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQW--LSCGERGLLV 177
Query: 186 FQHVSLMTLDTIMKCAFSHQGSIQVDRNS-QSYIQAISDLNNLVFSRVRNAFHQNDTIYS 244
+ V + M+ + + D +S Q ++A ++ +FS D +S
Sbjct: 178 YPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSL------PIDVPFS 231
Query: 245 LTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGS 304
G +A L H +Q I+ + L+ + K D L +L+ E G
Sbjct: 232 GLYRGM---KARNLIHARIEQNIRAKICGLRASEAGQGCK-----DALQLLIEHSWERGE 283
Query: 305 ILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHS--LL---GDGA 359
L + L+ +F GH+TTAS + ++ L +P ++ REE+ S LL
Sbjct: 284 RLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDN 343
Query: 360 SITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLH 419
+ L+Q+ Y IKE LRL PPVPG G ++ +G +PKG V+ SI H
Sbjct: 344 KLDMEILEQLKYIGCVIKETLRLNPPVPG-GFRVALKTFELNGYQIPKGWNVIYSICDTH 402
Query: 420 HNPKVWPNPEVFDPFRFA---PGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVAT 471
+++ N E F+P RF P A +F+PF GG R+C+GK+FA LK+ T
Sbjct: 403 DVAEIFTNKEEFNPDRFMLPHPEDASR-FSFIPFGGGLRSCVGKEFAKILLKIFT 456
>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
[Homo sapiens]
Length = 544
Score = 104 bits (260), Expect = 2e-22
Identities = 67/224 (29%), Positives = 107/224 (47%), Gaps = 8/224 (3%)
Query: 281 EKIKRKRHLDFLDILLL-----AKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILY 335
E + R+ DF+D+ LL K + S ++ L + G DTT + + W L
Sbjct: 307 ESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLL 366
Query: 336 ALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELST 395
++ +P QE+ EEI ++G + + QMPYT I E RL VP +++
Sbjct: 367 YMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTS 426
Query: 396 PVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQ--HSHAFLPFSGG 453
T G ++PKG ++L +++ +H +P +W PE F P RF Q F+PF G
Sbjct: 427 ENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIG 486
Query: 454 SRNCIGKQFAMNELKVATALTLLRFEL-LPDPTRIPIPIARLVL 496
R C+G+Q A EL + + F LP+ ++ P+ R L
Sbjct: 487 KRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTGRFGL 530
>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 103 bits (257), Expect = 4e-22
Identities = 60/195 (30%), Positives = 107/195 (54%), Gaps = 8/195 (4%)
Query: 318 FMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQ-MPYTTMCI 376
F+ G++ + +S+ Y LAT+P QE+ E+ + + L++ +PY M I
Sbjct: 339 FLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVI 398
Query: 377 KEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRF 436
E LR+YPP RE + G+ +P G ++ +++ LHH+P+ WP+PE F+P RF
Sbjct: 399 AETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERF 457
Query: 437 APGSAQHSHAF--LPFSGGSRNCIGKQFAMNELKVAT--ALTLLRFELLPDPTRIPIPI- 491
+ Q F LPF G R+C+G + + E+K+ L RF+ P+ T++P+ +
Sbjct: 458 TAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPE-TQVPLQLE 516
Query: 492 ARLVLKSKNGIHLRL 506
++ L KNG+++++
Sbjct: 517 SKSALGPKNGVYIKI 531
>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 103 bits (257), Expect = 4e-22
Identities = 60/195 (30%), Positives = 107/195 (54%), Gaps = 8/195 (4%)
Query: 318 FMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQ-MPYTTMCI 376
F+ G++ + +S+ Y LAT+P QE+ E+ + + L++ +PY M I
Sbjct: 339 FLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVI 398
Query: 377 KEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRF 436
E LR+YPP RE + G+ +P G ++ +++ LHH+P+ WP+PE F+P RF
Sbjct: 399 AETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERF 457
Query: 437 APGSAQHSHAF--LPFSGGSRNCIGKQFAMNELKVAT--ALTLLRFELLPDPTRIPIPI- 491
+ Q F LPF G R+C+G + + E+K+ L RF+ P+ T++P+ +
Sbjct: 458 TAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPE-TQVPLQLE 516
Query: 492 ARLVLKSKNGIHLRL 506
++ L KNG+++++
Sbjct: 517 SKSALGPKNGVYIKI 531
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.436
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,088,190
Number of Sequences: 37866
Number of extensions: 974006
Number of successful extensions: 2420
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2148
Number of HSP's gapped (non-prelim): 94
length of query: 519
length of database: 18,247,518
effective HSP length: 107
effective length of query: 412
effective length of database: 14,195,856
effective search space: 5848692672
effective search space used: 5848692672
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.