Search of human proteins with 15826840

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor
[Homo sapiens]
         (1070 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [...  2182   0.0  
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [...  2077   0.0  
gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [...  2027   0.0  
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [...  1110   0.0  
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur...   232   2e-60
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu...   231   3e-60
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo...   230   6e-60
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs...   228   2e-59
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur...   228   2e-59
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur...   228   2e-59
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo...   226   7e-59
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu...   226   9e-59
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo...   226   1e-58
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo...   226   1e-58
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu...   225   2e-58
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu...   225   2e-58
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu...   225   2e-58
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo...   224   3e-58
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur...   224   3e-58
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur...   224   3e-58
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor...   222   2e-57
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo...   221   2e-57
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu...   221   4e-57
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]    217   4e-56
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu...   213   1e-54
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu...   213   1e-54
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu...   213   1e-54
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu...   212   1e-54
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur...   211   3e-54
gi|29029632 anaplastic lymphoma kinase [Homo sapiens]                 210   5e-54

>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
            sapiens]
          Length = 1070

 Score = 2182 bits (5655), Expect = 0.0
 Identities = 1070/1070 (100%), Positives = 1070/1070 (100%)

Query: 1    MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
            MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1    MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60

Query: 61   VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
            VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61   VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120

Query: 121  IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
            IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121  IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180

Query: 181  KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
            KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181  KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240

Query: 241  EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
            EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241  EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300

Query: 301  CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
            CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301  CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360

Query: 361  VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420
            VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD
Sbjct: 361  VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420

Query: 421  SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480
            SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR
Sbjct: 421  SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480

Query: 481  CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 540
            CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD
Sbjct: 481  CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 540

Query: 541  GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 600
            GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER
Sbjct: 541  GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 600

Query: 601  TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 660
            TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG
Sbjct: 601  TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 660

Query: 661  RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 720
            RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL
Sbjct: 661  RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 720

Query: 721  GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 780
            GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN
Sbjct: 721  GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 780

Query: 781  KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 840
            KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ
Sbjct: 781  KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 840

Query: 841  LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 900
            LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ
Sbjct: 841  LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 900

Query: 901  PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 960
            PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY
Sbjct: 901  PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 960

Query: 961  YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 1020
            YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ
Sbjct: 961  YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 1020

Query: 1021 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1070
            AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP
Sbjct: 1021 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1070


>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [Homo
            sapiens]
          Length = 1030

 Score = 2077 bits (5381), Expect = 0.0
 Identities = 1030/1070 (96%), Positives = 1030/1070 (96%), Gaps = 40/1070 (3%)

Query: 1    MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
            MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1    MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60

Query: 61   VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
            VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61   VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120

Query: 121  IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
            IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121  IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180

Query: 181  KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
            KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181  KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240

Query: 241  EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
            EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241  EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300

Query: 301  CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
            CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301  CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360

Query: 361  VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420
            VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD
Sbjct: 361  VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420

Query: 421  SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480
            SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR
Sbjct: 421  SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480

Query: 481  CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 540
            CMSSTPAGSIEAQARVQVL                                        D
Sbjct: 481  CMSSTPAGSIEAQARVQVL----------------------------------------D 500

Query: 541  GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 600
            GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER
Sbjct: 501  GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 560

Query: 601  TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 660
            TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG
Sbjct: 561  TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 620

Query: 661  RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 720
            RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL
Sbjct: 621  RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 680

Query: 721  GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 780
            GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN
Sbjct: 681  GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 740

Query: 781  KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 840
            KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ
Sbjct: 741  KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 800

Query: 841  LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 900
            LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ
Sbjct: 801  LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 860

Query: 901  PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 960
            PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY
Sbjct: 861  PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 920

Query: 961  YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 1020
            YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ
Sbjct: 921  YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 980

Query: 1021 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1070
            AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP
Sbjct: 981  AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1030


>gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [Homo
            sapiens]
          Length = 1014

 Score = 2027 bits (5252), Expect = 0.0
 Identities = 1010/1070 (94%), Positives = 1011/1070 (94%), Gaps = 56/1070 (5%)

Query: 1    MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
            MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1    MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60

Query: 61   VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
            VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61   VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120

Query: 121  IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
            IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121  IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180

Query: 181  KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
            KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181  KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240

Query: 241  EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
            EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241  EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300

Query: 301  CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
            CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301  CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360

Query: 361  VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420
            VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD
Sbjct: 361  VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420

Query: 421  SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480
            SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR
Sbjct: 421  SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480

Query: 481  CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 540
            CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD
Sbjct: 481  CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 540

Query: 541  GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 600
            GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER
Sbjct: 541  GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 600

Query: 601  TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 660
            TTVYQGHTALLQCEAQGDPKPLIQWK K                           PE+S 
Sbjct: 601  TTVYQGHTALLQCEAQGDPKPLIQWKDKP-------------------------VPEES- 634

Query: 661  RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 720
                                          EGPGSPPPYKMIQTIGLSVGAAVAYIIAVL
Sbjct: 635  ------------------------------EGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 664

Query: 721  GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 780
            GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN
Sbjct: 665  GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 724

Query: 781  KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 840
            KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ
Sbjct: 725  KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 784

Query: 841  LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 900
            LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ
Sbjct: 785  LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 844

Query: 901  PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 960
            PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY
Sbjct: 845  PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 904

Query: 961  YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 1020
            YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ
Sbjct: 905  YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 964

Query: 1021 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1070
            AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP
Sbjct: 965  AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1014


>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [Homo
            sapiens]
          Length = 940

 Score = 1110 bits (2871), Expect = 0.0
 Identities = 604/913 (66%), Positives = 658/913 (72%), Gaps = 87/913 (9%)

Query: 232  QDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQV 291
            QD +  R   A+  C+  A  P  + WL  D  P+ +  R         FA GS L    
Sbjct: 41   QDALQGR--RALLRCEVEAPGPVHVYWLL-DGAPVQDTERR--------FAQGSSLSFAA 89

Query: 292  --RPRNAGIYRCIGQ----GQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLP 345
              R +++G ++C+ +    G+        A+ ++  IE  P+      +    +  T + 
Sbjct: 90   VDRLQDSGTFQCVARDDVTGEEARSA--NASFNIKWIEAGPVVLKHPASEAEIQPQTQVT 147

Query: 346  PK----GLPEPSVWWEHAGVRLP---THGRVYQKGHELVLANIAESDAGVYTCHAANLAG 398
             +    G P P+  W   G  L    ++  V  K   L L       +G+Y+C A +  G
Sbjct: 148  LRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFG 207

Query: 399  QRRQDVNITVATVPSWLKK----PQDSQLEEGKPGYLDCLTQATPKPTVVW-YRNQMLIS 453
            Q     N T++       +    PQD  +   +     C   A P P++ W + ++  I+
Sbjct: 208  QACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPIT 267

Query: 454  EDSR------FEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPP 507
              SR        VF NG+L +  V   +   YRC+     G          L +++  P 
Sbjct: 268  NRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPL 327

Query: 508  PQPQQCMEFDKEATVPCSATGREKPTIKWERA---------------------------- 539
             +P+      +E        G  +P++ WE A                            
Sbjct: 328  FEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAG 387

Query: 540  ----------------------DGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQ 577
                                  +GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQ
Sbjct: 388  VYTCHAANLAGQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQ 447

Query: 578  GQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKL 637
            GQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKL
Sbjct: 448  GQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKL 507

Query: 638  GPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPP 697
            GPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPP
Sbjct: 508  GPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPP 567

Query: 698  PYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNG 757
            PYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNG
Sbjct: 568  PYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNG 627

Query: 758  QPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQG 817
            QPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQG
Sbjct: 628  QPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQG 687

Query: 818  LEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEY 877
            LEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEY
Sbjct: 688  LEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEY 747

Query: 878  VDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCL 937
            VDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCL
Sbjct: 748  VDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCL 807

Query: 938  VSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMW 997
            VSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMW
Sbjct: 808  VSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMW 867

Query: 998  EVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEI 1057
            EVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEI
Sbjct: 868  EVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEI 927

Query: 1058 ASALGDSTVDSKP 1070
            ASALGDSTVDSKP
Sbjct: 928  ASALGDSTVDSKP 940



 Score =  855 bits (2208), Expect = 0.0
 Identities = 433/554 (78%), Positives = 454/554 (81%), Gaps = 53/554 (9%)

Query: 1   MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
           MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1   MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60

Query: 61  VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
           VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61  VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120

Query: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
           IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180

Query: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
           KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240

Query: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
           EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300

Query: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
           CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360

Query: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA---TVPSWLK- 416
           VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA   ++P W+  
Sbjct: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTD 420

Query: 417 ----------------------------------------------KPQDSQLEEGKPGY 430
                                                         +P+ + + +G    
Sbjct: 421 NAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTAL 480

Query: 431 LDCLTQATPKPTVVWYRNQMLISEDS---RFEVFKNGTLRINSVEVYDGTWYRCMSSTPA 487
           L C  Q  PKP + W     ++       R  +F+NG+L I+ V   D   Y C++    
Sbjct: 481 LQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSC 540

Query: 488 GSIEAQARVQVLEK 501
                +A + V++K
Sbjct: 541 NIKHTEAPLYVVDK 554



 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 61/272 (22%), Positives = 114/272 (41%), Gaps = 23/272 (8%)

Query: 414 WLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVE- 472
           ++K+P      +G+   L C  +A P P  V++       +D+     +  +L   +V+ 
Sbjct: 34  FIKQPSSQDALQGRRALLRCEVEA-PGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDR 92

Query: 473 VYDGTWYRCMS-----STPAGSIEAQARVQVLEKLKFT-PPPQPQQCMEFDKEATVPCSA 526
           + D   ++C++        A S  A   ++ +E        P  +  ++   + T+ C  
Sbjct: 93  LQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHI 152

Query: 527 TGREKPTIKWERADGSSLPEW-----VTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIR 581
            G  +PT +W R DG+ L +      V+     L       + +G Y+C A +   GQ  
Sbjct: 153 DGHPRPTYQWFR-DGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSA-FGQAC 210

Query: 582 AHVQLTVAV----FITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKL 637
           +    T+++    F    + P+   V +   A+  C+    P P +QW  +D      + 
Sbjct: 211 SSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRS 270

Query: 638 GP----RMHIFQNGSLVIHDVAPEDSGRYTCI 665
            P    R  +F NGSL++  V P ++G Y CI
Sbjct: 271 RPPHLRRATVFANGSLLLTQVRPRNAGIYRCI 302



 Score = 33.9 bits (76), Expect = 0.84
 Identities = 31/116 (26%), Positives = 43/116 (37%), Gaps = 19/116 (16%)

Query: 592 ITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVI 651
           I F  +P      QG  ALL+CE +      + W     +LD   +      F  GS + 
Sbjct: 32  IVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYW-----LLDGAPVQDTERRFAQGSSLS 86

Query: 652 HDVAP--EDSGRYTCIAGN------------SCNIKHTEAPLYVVDKPVPEESEGP 693
                  +DSG + C+A +            S NIK  EA   V+  P  E    P
Sbjct: 87  FAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQP 142



 Score = 33.9 bits (76), Expect = 0.84
 Identities = 31/116 (26%), Positives = 43/116 (37%), Gaps = 19/116 (16%)

Query: 32  IVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYW-----LLDGAPVQDTERRFAQGSSLS 86
           I F  +P      QG  ALL+CE +      + W     +LD   +      F  GS + 
Sbjct: 462 ITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVI 521

Query: 87  FAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQP 142
                  +DSG + C+A +            S NIK  EA   V+  P  E    P
Sbjct: 522 HDVAP--EDSGRYTCIAGN------------SCNIKHTEAPLYVVDKPVPEESEGP 563


>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
            [Homo sapiens]
          Length = 820

 Score =  232 bits (591), Expect = 2e-60
 Identities = 194/704 (27%), Positives = 320/704 (45%), Gaps = 98/704 (13%)

Query: 442  TVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEK 501
            ++ W R+ + ++E +R  +        +SV    G  Y C++S+P+GS      V V + 
Sbjct: 63   SINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGL-YACVTSSPSGSDTTYFSVNVSDA 121

Query: 502  LK-----------------------------FTPPPQPQQ---CMEFDKEATVPCSATGR 529
            L                              +T P + ++    +   K     C ++G 
Sbjct: 122  LPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGT 181

Query: 530  EKPTIKWERADGSSLPEW------VTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAH 583
              PT++W +      P+       V     ++    V   D GNYTCI  N   G I   
Sbjct: 182  PNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVEN-EYGSINHT 240

Query: 584  VQLTVAVFITFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLG 638
             QL V      +       P   TV  G      C+   DP+P IQW  K   ++ +K+G
Sbjct: 241  YQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL-KHIEVNGSKIG 299

Query: 639  PR----MHIFQNGSL--------VIH--DVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDK 684
            P     + I +   +        V+H  +V+ ED+G YTC+AGNS  + H  A L V++ 
Sbjct: 300  PDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE- 358

Query: 685  PVPEESEGPGSPPPYKMIQT-------IGLSVGAAVAYII------AVLGLMFYCKKRCK 731
               EE     + P Y  I         I   VG+ + Y +      +         K  K
Sbjct: 359  -ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK 417

Query: 732  AKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD--KM 789
            +  L++Q          +N G L        +     L+S G+   A    +   +  + 
Sbjct: 418  SIPLRRQVTVSADSSASMNSGVL--------LVRPSRLSSSGTPMLAGVSEYELPEDPRW 469

Query: 790  HFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRE 846
              PR  L     LG+  FG+V LA+A GL++      T V VK L+S   ++ L D   E
Sbjct: 470  ELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISE 529

Query: 847  LEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQP---- 901
            +EM   +  H N++ LLG C +  P Y+++EY   G+L+++L+  +    +    P    
Sbjct: 530  MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNP 589

Query: 902  ---LSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNS 958
               LS+K  V+   QVA GME+L++ + +H+DLAARN LV+    +K++  GL++D+++ 
Sbjct: 590  EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHI 649

Query: 959  EYY-HFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLA 1017
            +YY       +P++WM+PEA+ +  ++ +SDVW+FGVL+WE+FT G  P+ G   +E+  
Sbjct: 650  DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFK 709

Query: 1018 DLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
             L+ G  R+ +P  C ++LY +M+ CW   P  RP+F ++   L
Sbjct: 710  LLKEGH-RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 752



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 59/281 (20%), Positives = 101/281 (35%), Gaps = 59/281 (20%)

Query: 353 SVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA--- 409
           S+ W   GV+L    R    G E+ + +   +D+G+Y C  ++ +G      ++ V+   
Sbjct: 63  SINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDAL 122

Query: 410 --------------------------TVPSWLKKPQDSQ----LEEGKPGYLDCLTQATP 439
                                       P W    +  +    +   K     C +  TP
Sbjct: 123 PSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 182

Query: 440 KPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAGSIEAQAR 495
            PT+ W +N      D R   +K      ++ ++SV   D   Y C+     GSI    +
Sbjct: 183 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 242

Query: 496 VQVLEKLKFTPPPQ----PQQCMEFDKEATVPCSATGREKPTIKWER---ADGSSL-PE- 546
           + V+E+    P  Q      + +         C      +P I+W +    +GS + P+ 
Sbjct: 243 LDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDN 302

Query: 547 ----WVTDNAG---------TLHFARVTRDDAGNYTCIASN 574
                +   AG          LH   V+ +DAG YTC+A N
Sbjct: 303 LPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGN 343



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 76/327 (23%), Positives = 121/327 (37%), Gaps = 73/327 (22%)

Query: 140 IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYS 199
           + P   + LRC +    + +  W RDG  L++  SN T  + E  + ++ + P  SGLY+
Sbjct: 45  VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAE--SNRTRITGEE-VEVQDSVPADSGLYA 100

Query: 200 CCAHSAFGQACSSQNFTLSIAD--------------------------ESFARVVLAPQD 233
           C   S  G    +  F+++++D                             A    +P+ 
Sbjct: 101 CVTSSPSGS--DTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEK 158

Query: 234 V-----VVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSL 286
           +      V   +   F C  S  P P+L+WL   +       +P H        +A  S+
Sbjct: 159 MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSI 213

Query: 287 LLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSE 338
           ++  V P + G Y CI + + G    +  T  L  +E  P        L   +    GS 
Sbjct: 214 IMDSVVPSDKGNYTCIVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSN 270

Query: 339 ERVTCLPPKGLPEPSVWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANI 381
               C      P+P + W +H  V               L T G     K  E++ L N+
Sbjct: 271 VEFMCKVYSD-PQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 329

Query: 382 AESDAGVYTCHAANLAGQRRQDVNITV 408
           +  DAG YTC A N  G       +TV
Sbjct: 330 SFEDAGEYTCLAGNSIGLSHHSAWLTV 356



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 54/248 (21%), Positives = 87/248 (35%), Gaps = 49/248 (19%)

Query: 48  RALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ-DSGTFQCVAR-- 104
           R  LR +V++     + WL DG  + ++ R    G  +     D +  DSG + CV    
Sbjct: 54  RCRLRDDVQS-----INWLRDGVQLAESNRTRITGEEVEVQ--DSVPADSGLYACVTSSP 106

Query: 105 -------------------------DDVTGEEARSANASFNIK---WIEAGPVVLKHPAS 136
                                    DD + EE  + N   N     W     +  K  A 
Sbjct: 107 SGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAV 166

Query: 137 EAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEH 194
            A       V  +C   G P PT +W ++G           + V     ++ +    P  
Sbjct: 167 PAA----KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSD 222

Query: 195 SGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQ 251
            G Y+C   + +G    +  + L + + S  R +L    P +  VA      F C+  + 
Sbjct: 223 KGNYTCIVENEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 280

Query: 252 PPPSLQWL 259
           P P +QWL
Sbjct: 281 PQPHIQWL 288



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 42/193 (21%), Positives = 66/193 (34%), Gaps = 36/193 (18%)

Query: 345 PPKGLPEPSVWWEHAGVRL-PTHG----RVYQKGHELVLANIAESDAGVYTCHAANLAGQ 399
           P  G P P++ W   G    P H     +V      +++ ++  SD G YTC   N  G 
Sbjct: 177 PSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGS 236

Query: 400 RRQDVNITVATVPSWLKKPQDSQLEEGKPGYLD----------CLTQATPKPTVVWYR-- 447
                 + V       + P    L+ G P              C   + P+P + W +  
Sbjct: 237 INHTYQLDVVE-----RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI 291

Query: 448 --NQMLISEDSR--FEVFKNG----------TLRINSVEVYDGTWYRCMSSTPAGSIEAQ 493
             N   I  D+    ++ K             L + +V   D   Y C++    G     
Sbjct: 292 EVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHS 351

Query: 494 ARVQVLEKLKFTP 506
           A + VLE L+  P
Sbjct: 352 AWLTVLEALEERP 364


>gi|105990522 fibroblast growth factor receptor 1 isoform 1 precursor
            [Homo sapiens]
          Length = 822

 Score =  231 bits (589), Expect = 3e-60
 Identities = 194/706 (27%), Positives = 320/706 (45%), Gaps = 100/706 (14%)

Query: 442  TVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEK 501
            ++ W R+ + ++E +R  +        +SV    G  Y C++S+P+GS      V V + 
Sbjct: 63   SINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGL-YACVTSSPSGSDTTYFSVNVSDA 121

Query: 502  LK-------------------------------FTPPPQPQQ---CMEFDKEATVPCSAT 527
            L                                +T P + ++    +   K     C ++
Sbjct: 122  LPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS 181

Query: 528  GREKPTIKWERADGSSLPEW------VTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIR 581
            G   PT++W +      P+       V     ++    V   D GNYTCI  N   G I 
Sbjct: 182  GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVEN-EYGSIN 240

Query: 582  AHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTK 636
               QL V      +       P   TV  G      C+   DP+P IQW  K   ++ +K
Sbjct: 241  HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL-KHIEVNGSK 299

Query: 637  LGPR----MHIFQNGSL--------VIH--DVAPEDSGRYTCIAGNSCNIKHTEAPLYVV 682
            +GP     + I +   +        V+H  +V+ ED+G YTC+AGNS  + H  A L V+
Sbjct: 300  IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 359

Query: 683  DKPVPEESEGPGSPPPYKMIQT-------IGLSVGAAVAYII------AVLGLMFYCKKR 729
            +    EE     + P Y  I         I   VG+ + Y +      +         K 
Sbjct: 360  E--ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKL 417

Query: 730  CKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD-- 787
             K+  L++Q          +N G L        +     L+S G+   A    +   +  
Sbjct: 418  AKSIPLRRQVTVSADSSASMNSGVL--------LVRPSRLSSSGTPMLAGVSEYELPEDP 469

Query: 788  KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFR 844
            +   PR  L     LG+  FG+V LA+A GL++      T V VK L+S   ++ L D  
Sbjct: 470  RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLI 529

Query: 845  RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQP-- 901
             E+EM   +  H N++ LLG C +  P Y+++EY   G+L+++L+  +    +    P  
Sbjct: 530  SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSH 589

Query: 902  -----LSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVY 956
                 LS+K  V+   QVA GME+L++ + +H+DLAARN LV+    +K++  GL++D++
Sbjct: 590  NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH 649

Query: 957  NSEYY-HFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEV 1015
            + +YY       +P++WM+PEA+ +  ++ +SDVW+FGVL+WE+FT G  P+ G   +E+
Sbjct: 650  HIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL 709

Query: 1016 LADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
               L+ G  R+ +P  C ++LY +M+ CW   P  RP+F ++   L
Sbjct: 710  FKLLKEGH-RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 754



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 60/283 (21%), Positives = 105/283 (37%), Gaps = 61/283 (21%)

Query: 353 SVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA-TV 411
           S+ W   GV+L    R    G E+ + +   +D+G+Y C  ++ +G      ++ V+  +
Sbjct: 63  SINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDAL 122

Query: 412 PSWL-------KKPQDSQLEEGKPGYL---------------------------DCLTQA 437
           PS            ++ + +  KP  +                            C +  
Sbjct: 123 PSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG 182

Query: 438 TPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAGSIEAQ 493
           TP PT+ W +N      D R   +K      ++ ++SV   D   Y C+     GSI   
Sbjct: 183 TPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHT 242

Query: 494 ARVQVLEKLKFTPPPQ----PQQCMEFDKEATVPCSATGREKPTIKWER---ADGSSL-P 545
            ++ V+E+    P  Q      + +         C      +P I+W +    +GS + P
Sbjct: 243 YQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP 302

Query: 546 E-----WVTDNAG---------TLHFARVTRDDAGNYTCIASN 574
           +      +   AG          LH   V+ +DAG YTC+A N
Sbjct: 303 DNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGN 345



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 79/327 (24%), Positives = 124/327 (37%), Gaps = 71/327 (21%)

Query: 140 IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYS 199
           + P   + LRC +    + +  W RDG  L++  SN T  + E  + ++ + P  SGLY+
Sbjct: 45  VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAE--SNRTRITGEE-VEVQDSVPADSGLYA 100

Query: 200 CCAHSAFGQACSSQNFTLSIA----------DESFA-----------RVVLAPQDVVVAR 238
           C   S  G   +  +  +S A          D+S +           R+ +AP      +
Sbjct: 101 CVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEK 160

Query: 239 YEEAM----------FHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSL 286
            E+ +          F C  S  P P+L+WL   +       +P H        +A  S+
Sbjct: 161 MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSI 215

Query: 287 LLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSE 338
           ++  V P + G Y CI + + G    +  T  L  +E  P        L   +    GS 
Sbjct: 216 IMDSVVPSDKGNYTCIVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSN 272

Query: 339 ERVTCLPPKGLPEPSVWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANI 381
               C      P+P + W +H  V               L T G     K  E++ L N+
Sbjct: 273 VEFMCKVYSD-PQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 331

Query: 382 AESDAGVYTCHAANLAGQRRQDVNITV 408
           +  DAG YTC A N  G       +TV
Sbjct: 332 SFEDAGEYTCLAGNSIGLSHHSAWLTV 358



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 51/246 (20%), Positives = 87/246 (35%), Gaps = 43/246 (17%)

Query: 48  RALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ-DSGTFQCVAR-- 104
           R  LR +V++     + WL DG  + ++ R    G  +     D +  DSG + CV    
Sbjct: 54  RCRLRDDVQS-----INWLRDGVQLAESNRTRITGEEVEVQ--DSVPADSGLYACVTSSP 106

Query: 105 -------------------------DDVTGEEARSANASFNIKWIEAGPVVLKHPASEAE 139
                                    DD + EE  + N   N   +       +    +  
Sbjct: 107 SGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLH 166

Query: 140 IQPQTQ-VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSG 196
             P  + V  +C   G P PT +W ++G           + V     ++ +    P   G
Sbjct: 167 AVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKG 226

Query: 197 LYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPP 253
            Y+C   + +G    +  + L + + S  R +L    P +  VA      F C+  + P 
Sbjct: 227 NYTCIVENEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQ 284

Query: 254 PSLQWL 259
           P +QWL
Sbjct: 285 PHIQWL 290



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 42/193 (21%), Positives = 66/193 (34%), Gaps = 36/193 (18%)

Query: 345 PPKGLPEPSVWWEHAGVRL-PTHG----RVYQKGHELVLANIAESDAGVYTCHAANLAGQ 399
           P  G P P++ W   G    P H     +V      +++ ++  SD G YTC   N  G 
Sbjct: 179 PSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGS 238

Query: 400 RRQDVNITVATVPSWLKKPQDSQLEEGKPGYLD----------CLTQATPKPTVVWYR-- 447
                 + V       + P    L+ G P              C   + P+P + W +  
Sbjct: 239 INHTYQLDVVE-----RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI 293

Query: 448 --NQMLISEDSR--FEVFKNG----------TLRINSVEVYDGTWYRCMSSTPAGSIEAQ 493
             N   I  D+    ++ K             L + +V   D   Y C++    G     
Sbjct: 294 EVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHS 353

Query: 494 ARVQVLEKLKFTP 506
           A + VLE L+  P
Sbjct: 354 AWLTVLEALEERP 366


>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform c
            precursor [Homo sapiens]
          Length = 822

 Score =  230 bits (586), Expect = 6e-60
 Identities = 178/615 (28%), Positives = 283/615 (46%), Gaps = 74/615 (12%)

Query: 510  PQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNA-GTLHFARVTRDDAGNY 568
            P   +E  K  T+ CS  G   P + W+  +  S     T +  G+L    ++ DD+G  
Sbjct: 204  PNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQ 263

Query: 569  -TCIASNGPQGQIRAHVQLTV--AVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW 625
             +C+A N   G+ +  V LTV  A  ITF   P        H   +    +G+PKP +QW
Sbjct: 264  ISCVAEN-LVGEDQDSVNLTVHFAPTITFLESPT-----SDHHWCIPFTVKGNPKPALQW 317

Query: 626  KGKDRILDP-----TKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLY 680
                 IL+      TK+    H   +G L + +    ++G YT IA N       +   +
Sbjct: 318  FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH 377

Query: 681  VVDKPVPEESEGPGSPPP-YKMIQTIGLSVGA-------------------------AVA 714
             +  P  ++   P  P   Y+   T    +G                          AV 
Sbjct: 378  FMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVV 437

Query: 715  YIIAVLG-----LMFYCKKRCKAKRLQKQP--------EGEEPEMECLNGGPLQNGQPSA 761
             I +V+G     ++F  K    +K   K P        +   P     NG    N   S+
Sbjct: 438  VIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGS---NTPSSS 494

Query: 762  EIQEEVALTSLGSGPAATNKRHS--TSDKM-------HFPRSSLQPITTLGKSEFGEVFL 812
            E   +  +  +   P   N ++   T+ ++       H  R ++     LG+  FG+VFL
Sbjct: 495  EGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFL 554

Query: 813  AKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHY 872
            A+   L     + LV VK+L+   +  + DF RE E+   L H ++V+  G+C E +P  
Sbjct: 555  AECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLI 614

Query: 873  MVLEYVDLGDLKQFLRISKSKDEKLKSQ-----PLSTKQKVALCTQVALGMEHLSNNRFV 927
            MV EY+  GDL +FLR +   D  L ++      L+  Q + +  Q+A GM +L++  FV
Sbjct: 615  MVFEYMKHGDLNKFLR-AHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFV 673

Query: 928  HKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTK 986
            H+DLA RNCLV     VK+   G+S+DVY+++YY       +P+RWM PE+I+   F+T+
Sbjct: 674  HRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTE 733

Query: 987  SDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWAL 1046
            SDVW+ GV++WE+FT+G+ P    +++EV+  +  G+  L +P  CP ++Y LM  CW  
Sbjct: 734  SDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRV-LQRPRTCPQEVYELMLGCWQR 792

Query: 1047 SPKDRPSFSEIASAL 1061
             P  R +   I + L
Sbjct: 793  EPHMRKNIKGIHTLL 807



 Score = 37.4 bits (85), Expect = 0.076
 Identities = 36/172 (20%), Positives = 68/172 (39%), Gaps = 20/172 (11%)

Query: 45  QGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVAR 104
           +G+   L C V      ++YW +     +          SL    +          CVA 
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVA- 268

Query: 105 DDVTGEEARSANASFNIKWIEAGPVV--LKHPASEAEIQPQTQVTLRCHIDGHPRPTYQW 162
           +++ GE+  S N +     +   P +  L+ P S+          +   + G+P+P  QW
Sbjct: 269 ENLVGEDQDSVNLT-----VHFAPTITFLESPTSDHHW------CIPFTVKGNPKPALQW 317

Query: 163 FRDGTPLSDGQ----SNHTVSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQ 208
           F +G  L++ +      H  +  E +  L+   P H  +G Y+  A + +G+
Sbjct: 318 FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK 369



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 44/179 (24%), Positives = 66/179 (36%), Gaps = 18/179 (10%)

Query: 135 ASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEH 194
           A    ++    +TL C + G P P   W  D   L     N T S  + +L +     + 
Sbjct: 203 APNLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNET-SHTQGSLRITNISSDD 259

Query: 195 SG-LYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPP 253
           SG   SC A +  G+   S N T+      FA  +   +      +    F       P 
Sbjct: 260 SGKQISCVAENLVGEDQDSVNLTV-----HFAPTITFLESPTSDHHWCIPF--TVKGNPK 312

Query: 254 PSLQWLFEDETPITNRSR----PPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
           P+LQW +     I N S+      H+   T + +G L L      N G Y  I + + G
Sbjct: 313 PALQWFYNG--AILNESKYICTKIHVTNHTEY-HGCLQLDNPTHMNNGDYTLIAKNEYG 368


>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
            [Homo sapiens]
          Length = 806

 Score =  228 bits (582), Expect = 2e-59
 Identities = 180/594 (30%), Positives = 273/594 (45%), Gaps = 77/594 (12%)

Query: 524  CSATGREKPTIKW----------ERADGSSL--PEWVTDNAGTLHFARVTRDDAGNYTCI 571
            C A G   P+I W           R  G  L   +W      +L    V   D GNYTC+
Sbjct: 176  CPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQW------SLVMESVVPSDRGNYTCV 229

Query: 572  ASNGPQGQIRAHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWK 626
              N   G IR    L V      +       P   T   G      C+   D +P IQW 
Sbjct: 230  VEN-KFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWL 288

Query: 627  GKDRILDPTKLGPR----MHIFQNGS----------LVIHDVAPEDSGRYTCIAGNSCNI 672
             K   ++ +K+GP     + + +             L +H+V  ED+G YTC+AGNS   
Sbjct: 289  -KHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGF 347

Query: 673  KHTEAPLYVVDKPVPEES-EGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCK 731
             H  A L V+  P  EE  E   +   Y  I    LS G      I V+  +  C+ R  
Sbjct: 348  SHHSAWLVVL--PAEEELVEADEAGSVYAGI----LSYGVGFFLFILVVAAVTLCRLRSP 401

Query: 732  AKR---------LQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKR 782
             K+         + + P   +  +E  +   + +  P   I    A  S G GP   N  
Sbjct: 402  PKKGLGSPTVHKISRFPLKRQVSLE--SNASMSSNTPLVRI----ARLSSGEGPTLANVS 455

Query: 783  H---STSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQ 839
                    K    R+ L     LG+  FG+V +A+A G+++  A   V V     KD+  
Sbjct: 456  ELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDAT 515

Query: 840  QLDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK---- 891
              D      E+EM   +  H N++ LLG C +  P Y+++EY   G+L++FLR  +    
Sbjct: 516  DKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGL 575

Query: 892  --SKDE-KLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSA 948
              S D  K   + L+ K  V+   QVA GME+L++ + +H+DLAARN LV+    +K++ 
Sbjct: 576  DYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIAD 635

Query: 949  LGLSKDVYNSEYY-HFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPH 1007
             GL++DV+N +YY       +P++WM+PEA+ +  ++ +SDVW+FGVL+WE+FT G  P+
Sbjct: 636  FGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPY 695

Query: 1008 GGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
             G   +E+   L+ G  R+ +P  C   LY +M+ CW  +P  RP+F ++   L
Sbjct: 696  PGIPVEELFKLLKEGH-RMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 748



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 70/298 (23%), Positives = 104/298 (34%), Gaps = 53/298 (17%)

Query: 329 EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGV 388
           E  VF +G    ++C PP G P     W   G  L    RV      L + N +  D+G 
Sbjct: 47  EQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGA 106

Query: 389 YTCHAANLAGQRRQDVNITVATVPS------WLKKPQDSQLEEGKPGY------------ 430
           Y+C    L  +     ++ V   PS         + +D+ ++ G P +            
Sbjct: 107 YSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLA 165

Query: 431 --------LDCLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTW 478
                     C     P P++ W +N      + R    K      +L + SV   D   
Sbjct: 166 VPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGN 225

Query: 479 YRCMSSTPAGSIEAQARVQVLEKLKFTPPPQ----PQQCMEFDKEATVPCSATGREKPTI 534
           Y C+     GSI     + VLE+    P  Q      Q      +    C      +P I
Sbjct: 226 YTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHI 285

Query: 535 KWER---ADGSSL-PE-----WVTDNAG---------TLHFARVTRDDAGNYTCIASN 574
           +W +    +GS + P+      V   AG          L    VT +DAG YTC+A N
Sbjct: 286 QWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGN 343



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 55/259 (21%), Positives = 90/259 (34%), Gaps = 48/259 (18%)

Query: 37  QPSSQDAL---QGRRALLRCEVEAPGPVH-VYWLLDGAPVQDTERRFAQGSSLSFAAVDR 92
           +P  Q+ L    G    L C     GP+    W+ DG  +  +ER       L       
Sbjct: 42  EPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASH 101

Query: 93  LQDSGTFQCVAR--------------------DDVTGEEARSANASFNIKWIEAGPVVLK 132
            +DSG + C  R                    DD  GE+            ++ G     
Sbjct: 102 -EDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTG------VDTGAPYWT 154

Query: 133 HPASEAE----IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS-----KER 183
            P    +    +     V  RC   G+P P+  W ++G    + +  H +       ++ 
Sbjct: 155 RPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNG---REFRGEHRIGGIKLRHQQW 211

Query: 184 NLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYE 240
           +L +    P   G Y+C   + FG     Q +TL + + S  R +L    P +       
Sbjct: 212 SLVMESVVPSDRGNYTCVVENKFGSI--RQTYTLDVLERSPHRPILQAGLPANQTAVLGS 269

Query: 241 EAMFHCQFSAQPPPSLQWL 259
           +  FHC+  +   P +QWL
Sbjct: 270 DVEFHCKVYSDAQPHIQWL 288



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 64/254 (25%), Positives = 91/254 (35%), Gaps = 50/254 (19%)

Query: 506 PPPQPQQCMEFDK----EATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVT 561
           P P  Q+ + F      E + P    G   PT+  +   G    E V      L     +
Sbjct: 41  PEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNAS 100

Query: 562 RDDAGNYTCIASNGPQGQIRAHVQLT-------------------VAVFITFKVEPERT- 601
            +D+G Y+C      +      V++T                   V     +   PER  
Sbjct: 101 HEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMD 160

Query: 602 ----TVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVIHDVAP 656
                V   +T   +C A G+P P I W K         ++G      Q  SLV+  V P
Sbjct: 161 KKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVP 220

Query: 657 EDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAY 715
            D G YTC+  N   +I+ T    Y +D  V E S       P++ I   GL        
Sbjct: 221 SDRGNYTCVVENKFGSIRQT----YTLD--VLERS-------PHRPILQAGLPANQT--- 264

Query: 716 IIAVLG--LMFYCK 727
             AVLG  + F+CK
Sbjct: 265 --AVLGSDVEFHCK 276



 Score = 34.7 bits (78), Expect = 0.49
 Identities = 66/294 (22%), Positives = 97/294 (32%), Gaps = 62/294 (21%)

Query: 154 GHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQ 213
           G P     W +DGT L   +    V    + L +  A  E SG YSC         C   
Sbjct: 66  GGPMGPTVWVKDGTGLVPSER---VLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLC--- 119

Query: 214 NFTLSIAD-------------------ESFARVVLAPQDV-----VVARYEEAMFHCQFS 249
           +F++ + D                   ++ A     P+ +      V       F C  +
Sbjct: 120 HFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAA 179

Query: 250 AQPPPSLQWLFED-ETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
             P PS+ WL    E    +R     LR        SL++  V P + G Y C+ + + G
Sbjct: 180 GNPTPSISWLKNGREFRGEHRIGGIKLRHQ----QWSLVMESVVPSDRGNYTCVVENKFG 235

Query: 309 PPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHA- 359
               +  T  L  +E  P        L   +    GS+    C           W +H  
Sbjct: 236 S---IRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVE 292

Query: 360 --GVRLPTHGRVY-------------QKGHELVLANIAESDAGVYTCHAANLAG 398
             G ++   G  Y             ++   L L N+   DAG YTC A N  G
Sbjct: 293 VNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIG 346


>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
            [Homo sapiens]
          Length = 731

 Score =  228 bits (582), Expect = 2e-59
 Identities = 176/596 (29%), Positives = 283/596 (47%), Gaps = 65/596 (10%)

Query: 518  KEATVPCSATGREKPTIKWERADGSSLPEW------VTDNAGTLHFARVTRDDAGNYTCI 571
            K     C ++G   PT++W +      P+       V     ++    V   D GNYTCI
Sbjct: 81   KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCI 140

Query: 572  ASNGPQGQIRAHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWK 626
              N   G I    QL V      +       P   TV  G      C+   DP+P IQW 
Sbjct: 141  VEN-EYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL 199

Query: 627  GKDRILDPTKLGPR----MHIFQNGSL--------VIH--DVAPEDSGRYTCIAGNSCNI 672
             K   ++ +K+GP     + I +   +        V+H  +V+ ED+G YTC+AGNS  +
Sbjct: 200  -KHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGL 258

Query: 673  KHTEAPLYVVDKPVPEESEGPGSPPPYKMIQT-------IGLSVGAAVAYII------AV 719
             H  A L V++    EE     + P Y  I         I   VG+ + Y +      + 
Sbjct: 259  SHHSAWLTVLE--ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSD 316

Query: 720  LGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAAT 779
                    K  K+  L++Q          +N G L        +     L+S G+   A 
Sbjct: 317  FHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVL--------LVRPSRLSSSGTPMLAG 368

Query: 780  NKRHSTSD--KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSK 835
               +   +  +   PR  L     LG+  FG+V LA+A GL++      T V VK L+S 
Sbjct: 369  VSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD 428

Query: 836  DEQQQL-DFRRELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSK 893
              ++ L D   E+EM   +  H N++ LLG C +  P Y+++EY   G+L+++L+  +  
Sbjct: 429  ATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPP 488

Query: 894  DEKLKSQP-------LSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKV 946
              +    P       LS+K  V+   QVA GME+L++ + +H+DLAARN LV+    +K+
Sbjct: 489  GLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 548

Query: 947  SALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEM 1005
            +  GL++D+++ +YY       +P++WM+PEA+ +  ++ +SDVW+FGVL+WE+FT G  
Sbjct: 549  ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 608

Query: 1006 PHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
            P+ G   +E+   L+ G  R+ +P  C ++LY +M+ CW   P  RP+F ++   L
Sbjct: 609  PYPGVPVEELFKLLKEGH-RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 663



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 42/168 (25%), Positives = 67/168 (39%), Gaps = 26/168 (15%)

Query: 433 CLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAG 488
           C +  TP PT+ W +N      D R   +K      ++ ++SV   D   Y C+     G
Sbjct: 87  CPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYG 146

Query: 489 SIEAQARVQVLEKLKFTPPPQ----PQQCMEFDKEATVPCSATGREKPTIKWER---ADG 541
           SI    ++ V+E+    P  Q      + +         C      +P I+W +    +G
Sbjct: 147 SINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNG 206

Query: 542 SSL-PE-----WVTDNAG---------TLHFARVTRDDAGNYTCIASN 574
           S + P+      +   AG          LH   V+ +DAG YTC+A N
Sbjct: 207 SKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGN 254



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 28/119 (23%), Positives = 48/119 (40%), Gaps = 7/119 (5%)

Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
           V  +C   G P PT +W ++G           + V     ++ +    P   G Y+C   
Sbjct: 83  VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 142

Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
           + +G    +  + L + + S  R +L    P +  VA      F C+  + P P +QWL
Sbjct: 143 NEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL 199



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 15/122 (12%)

Query: 595 KVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPT-KLGPRMHIFQNGSLVIHD 653
           K+E +   V    T   +C + G P P ++W    +   P  ++G     +   S+++  
Sbjct: 69  KMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDS 128

Query: 654 VAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAA 712
           V P D G YTCI  N   +I HT    Y +D  V E S       P++ I   GL     
Sbjct: 129 VVPSDKGNYTCIVENEYGSINHT----YQLD--VVERS-------PHRPILQAGLPANKT 175

Query: 713 VA 714
           VA
Sbjct: 176 VA 177



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 50/192 (26%), Positives = 72/192 (37%), Gaps = 36/192 (18%)

Query: 244 FHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSLLLTQVRPRNAGIYRC 301
           F C  S  P P+L+WL   +       +P H        +A  S+++  V P + G Y C
Sbjct: 85  FKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC 139

Query: 302 IGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGLPEPS 353
           I + + G    +  T  L  +E  P        L   +    GS     C      P+P 
Sbjct: 140 IVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD-PQPH 195

Query: 354 VWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANIAESDAGVYTCHAANL 396
           + W +H  V               L T G     K  E++ L N++  DAG YTC A N 
Sbjct: 196 IQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNS 255

Query: 397 AGQRRQDVNITV 408
            G       +TV
Sbjct: 256 IGLSHHSAWLTV 267



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 42/193 (21%), Positives = 66/193 (34%), Gaps = 36/193 (18%)

Query: 345 PPKGLPEPSVWWEHAGVRL-PTHG----RVYQKGHELVLANIAESDAGVYTCHAANLAGQ 399
           P  G P P++ W   G    P H     +V      +++ ++  SD G YTC   N  G 
Sbjct: 88  PSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGS 147

Query: 400 RRQDVNITVATVPSWLKKPQDSQLEEGKPGYLD----------CLTQATPKPTVVWYR-- 447
                 + V       + P    L+ G P              C   + P+P + W +  
Sbjct: 148 INHTYQLDVVE-----RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI 202

Query: 448 --NQMLISEDSR--FEVFKNG----------TLRINSVEVYDGTWYRCMSSTPAGSIEAQ 493
             N   I  D+    ++ K             L + +V   D   Y C++    G     
Sbjct: 203 EVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHS 262

Query: 494 ARVQVLEKLKFTP 506
           A + VLE L+  P
Sbjct: 263 AWLTVLEALEERP 275


>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
            [Homo sapiens]
          Length = 733

 Score =  228 bits (582), Expect = 2e-59
 Identities = 176/596 (29%), Positives = 283/596 (47%), Gaps = 65/596 (10%)

Query: 518  KEATVPCSATGREKPTIKWERADGSSLPEW------VTDNAGTLHFARVTRDDAGNYTCI 571
            K     C ++G   PT++W +      P+       V     ++    V   D GNYTCI
Sbjct: 83   KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCI 142

Query: 572  ASNGPQGQIRAHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWK 626
              N   G I    QL V      +       P   TV  G      C+   DP+P IQW 
Sbjct: 143  VEN-EYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL 201

Query: 627  GKDRILDPTKLGPR----MHIFQNGSL--------VIH--DVAPEDSGRYTCIAGNSCNI 672
             K   ++ +K+GP     + I +   +        V+H  +V+ ED+G YTC+AGNS  +
Sbjct: 202  -KHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGL 260

Query: 673  KHTEAPLYVVDKPVPEESEGPGSPPPYKMIQT-------IGLSVGAAVAYII------AV 719
             H  A L V++    EE     + P Y  I         I   VG+ + Y +      + 
Sbjct: 261  SHHSAWLTVLE--ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSD 318

Query: 720  LGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAAT 779
                    K  K+  L++Q          +N G L        +     L+S G+   A 
Sbjct: 319  FHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVL--------LVRPSRLSSSGTPMLAG 370

Query: 780  NKRHSTSD--KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSK 835
               +   +  +   PR  L     LG+  FG+V LA+A GL++      T V VK L+S 
Sbjct: 371  VSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD 430

Query: 836  DEQQQL-DFRRELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSK 893
              ++ L D   E+EM   +  H N++ LLG C +  P Y+++EY   G+L+++L+  +  
Sbjct: 431  ATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPP 490

Query: 894  DEKLKSQP-------LSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKV 946
              +    P       LS+K  V+   QVA GME+L++ + +H+DLAARN LV+    +K+
Sbjct: 491  GLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 550

Query: 947  SALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEM 1005
            +  GL++D+++ +YY       +P++WM+PEA+ +  ++ +SDVW+FGVL+WE+FT G  
Sbjct: 551  ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 610

Query: 1006 PHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
            P+ G   +E+   L+ G  R+ +P  C ++LY +M+ CW   P  RP+F ++   L
Sbjct: 611  PYPGVPVEELFKLLKEGH-RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 665



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 42/168 (25%), Positives = 67/168 (39%), Gaps = 26/168 (15%)

Query: 433 CLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAG 488
           C +  TP PT+ W +N      D R   +K      ++ ++SV   D   Y C+     G
Sbjct: 89  CPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYG 148

Query: 489 SIEAQARVQVLEKLKFTPPPQ----PQQCMEFDKEATVPCSATGREKPTIKWER---ADG 541
           SI    ++ V+E+    P  Q      + +         C      +P I+W +    +G
Sbjct: 149 SINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNG 208

Query: 542 SSL-PE-----WVTDNAG---------TLHFARVTRDDAGNYTCIASN 574
           S + P+      +   AG          LH   V+ +DAG YTC+A N
Sbjct: 209 SKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGN 256



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 28/119 (23%), Positives = 48/119 (40%), Gaps = 7/119 (5%)

Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
           V  +C   G P PT +W ++G           + V     ++ +    P   G Y+C   
Sbjct: 85  VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 144

Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
           + +G    +  + L + + S  R +L    P +  VA      F C+  + P P +QWL
Sbjct: 145 NEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL 201



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 15/122 (12%)

Query: 595 KVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPT-KLGPRMHIFQNGSLVIHD 653
           K+E +   V    T   +C + G P P ++W    +   P  ++G     +   S+++  
Sbjct: 71  KMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDS 130

Query: 654 VAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAA 712
           V P D G YTCI  N   +I HT    Y +D  V E S       P++ I   GL     
Sbjct: 131 VVPSDKGNYTCIVENEYGSINHT----YQLD--VVERS-------PHRPILQAGLPANKT 177

Query: 713 VA 714
           VA
Sbjct: 178 VA 179



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 50/192 (26%), Positives = 72/192 (37%), Gaps = 36/192 (18%)

Query: 244 FHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSLLLTQVRPRNAGIYRC 301
           F C  S  P P+L+WL   +       +P H        +A  S+++  V P + G Y C
Sbjct: 87  FKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC 141

Query: 302 IGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGLPEPS 353
           I + + G    +  T  L  +E  P        L   +    GS     C      P+P 
Sbjct: 142 IVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD-PQPH 197

Query: 354 VWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANIAESDAGVYTCHAANL 396
           + W +H  V               L T G     K  E++ L N++  DAG YTC A N 
Sbjct: 198 IQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNS 257

Query: 397 AGQRRQDVNITV 408
            G       +TV
Sbjct: 258 IGLSHHSAWLTV 269



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 42/193 (21%), Positives = 66/193 (34%), Gaps = 36/193 (18%)

Query: 345 PPKGLPEPSVWWEHAGVRL-PTHG----RVYQKGHELVLANIAESDAGVYTCHAANLAGQ 399
           P  G P P++ W   G    P H     +V      +++ ++  SD G YTC   N  G 
Sbjct: 90  PSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGS 149

Query: 400 RRQDVNITVATVPSWLKKPQDSQLEEGKPGYLD----------CLTQATPKPTVVWYR-- 447
                 + V       + P    L+ G P              C   + P+P + W +  
Sbjct: 150 INHTYQLDVVE-----RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI 204

Query: 448 --NQMLISEDSR--FEVFKNG----------TLRINSVEVYDGTWYRCMSSTPAGSIEAQ 493
             N   I  D+    ++ K             L + +V   D   Y C++    G     
Sbjct: 205 EVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHS 264

Query: 494 ARVQVLEKLKFTP 506
           A + VLE L+  P
Sbjct: 265 AWLTVLEALEERP 277


>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform b
            precursor [Homo sapiens]
          Length = 825

 Score =  226 bits (577), Expect = 7e-59
 Identities = 176/602 (29%), Positives = 279/602 (46%), Gaps = 67/602 (11%)

Query: 520  ATVPCSATGREKPTIKWERADGSSLP------EWVTDNAGTLHFARVTRDDAG-NYTCIA 572
            A + C+ +G   P + W      S+        W   +A  L    VT +D G   TCIA
Sbjct: 227  AVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIA 286

Query: 573  SNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC---EAQGDPKPLIQWKGKD 629
             N   G   A V LTV         P   ++ +    L  C     +G+P P + W    
Sbjct: 287  EN-VVGMSNASVALTVYY------PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNG 339

Query: 630  RILDPTKLGPRMHI-------FQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVV 682
            + L  +K+   +H+          G L+ +     ++G YT IA N     +     + +
Sbjct: 340  QPLRESKI---IHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFL 396

Query: 683  DKPVPEESEG-----PGSPPPYKMI------QTIGLSVG---AAVAYIIAVLGLMFYCKK 728
             +P PE ++        SP P   +       T G+S+    AA A ++ V+  +   K 
Sbjct: 397  KEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKY 456

Query: 729  RCKAKRLQKQP----EGEEPEMECLNGGPLQNGQPSA-EIQEEVALTSLGSGPAATNKRH 783
              ++K   K P     GEE     L+        PS+ +   +  +  +   P   N ++
Sbjct: 457  GRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQY 516

Query: 784  -STSDKMHFPRSSLQPITT--------LGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQS 834
                   H P + +Q I          LG+  FG+VFLA+   L     + LV VK+L+ 
Sbjct: 517  FRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKD 576

Query: 835  KDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLR------ 888
                 + DF+RE E+   L H ++V+  G+C + +P  MV EY+  GDL +FLR      
Sbjct: 577  PTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDA 636

Query: 889  -ISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVS 947
             I      +     L   Q + + +Q+A GM +L++  FVH+DLA RNCLV A   VK+ 
Sbjct: 637  MILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIG 696

Query: 948  ALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMP 1006
              G+S+DVY+++YY       +P+RWM PE+I+   F+T+SDVW+FGV++WE+FT+G+ P
Sbjct: 697  DFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP 756

Query: 1007 HGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSE---IASALGD 1063
                ++ EV+  +  G+  L +P  CP ++Y +M  CW   P+ R +  E   I  ALG 
Sbjct: 757  WFQLSNTEVIECITQGRV-LERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGK 815

Query: 1064 ST 1065
            +T
Sbjct: 816  AT 817



 Score = 38.1 bits (87), Expect = 0.045
 Identities = 44/170 (25%), Positives = 62/170 (36%), Gaps = 23/170 (13%)

Query: 336 GSEERVTCLPPKGLPEPSVWWEHAGVR-LPTH--GRVYQKGH--ELVLANIAESDAG-VY 389
           G    +TC    G P P V W   G++ + TH     +   H   L L N+   D G   
Sbjct: 224 GDNAVITC-NGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282

Query: 390 TCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL---TQATPKPTVVWY 446
           TC A N+ G     V +TV         P+   LEE +     C+    +  P PT+ W 
Sbjct: 283 TCIAENVVGMSNASVALTV------YYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWL 336

Query: 447 RNQMLISEDSRFEV-------FKNGTLRINSVEVYDGTWYRCMSSTPAGS 489
            N   + E     V          G L  N    Y+   Y  ++  P G+
Sbjct: 337 HNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGT 386



 Score = 34.3 bits (77), Expect = 0.65
 Identities = 39/150 (26%), Positives = 57/150 (38%), Gaps = 22/150 (14%)

Query: 567 NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW- 625
           N  CI ++G Q  +   + ++        V     TV +G  A++ C   G P P + W 
Sbjct: 186 NLYCINADGSQLPL-FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWI 244

Query: 626 -KGKDRI-LDPTKLG-PRMHIFQNGSLVIHDVAPEDSG-RYTCIAGNSCNIKHTEAPLYV 681
             G   I    T L    +H     +L + +V  ED+G   TCIA N   + +    L V
Sbjct: 245 VTGLQSINTHQTNLNWTNVHAI---NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV 301

Query: 682 VDKPVPEESEGP-------------GSPPP 698
              P     E P             G+PPP
Sbjct: 302 YYPPRVVSLEEPELRLEHCIEFVVRGNPPP 331



 Score = 33.9 bits (76), Expect = 0.84
 Identities = 44/203 (21%), Positives = 72/203 (35%), Gaps = 22/203 (10%)

Query: 215 FTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPH 274
           F ++I+      + ++  ++ V   + A+  C  S  P P + W+      I   +   +
Sbjct: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSI--NTHQTN 257

Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334
           L    V A    L+      N     CI +   G        +  A +     + PRV +
Sbjct: 258 LNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG--------MSNASVALTVYYPPRVVS 309

Query: 335 AGSEE--RVTCLP--PKGLPEPSVWWEHAGVRLP----THGRVYQKGHE----LVLANIA 382
               E     C+    +G P P++ W H G  L      H   YQ+G      L+     
Sbjct: 310 LEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPT 369

Query: 383 ESDAGVYTCHAANLAGQRRQDVN 405
             + G YT  A N  G   Q +N
Sbjct: 370 HYNNGNYTLIAKNPLGTANQTIN 392



 Score = 31.6 bits (70), Expect = 4.2
 Identities = 41/180 (22%), Positives = 75/180 (41%), Gaps = 20/180 (11%)

Query: 45  QGRRALLRCEVEAPGPVHVYWLLDGAP---VQDTERRFAQGSSLSFAAVD-RLQDSG-TF 99
           +G  A++ C         V W++ G        T   +    +++   V+   +D+G T 
Sbjct: 223 EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282

Query: 100 QCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPT 159
            C+A ++V G     +NAS  +  +   P V+     E  ++   +  +R    G+P PT
Sbjct: 283 TCIA-ENVVG----MSNASVALT-VYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPT 332

Query: 160 YQWFRDGTPLSDGQSNHTVSSKERNLT---LRPAGPEH--SGLYSCCAHSAFGQACSSQN 214
             W  +G PL + +  H    +E  ++   L    P H  +G Y+  A +  G A  + N
Sbjct: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392


>gi|222144241 fibroblast growth factor receptor 2 isoform 8 precursor
            [Homo sapiens]
          Length = 704

 Score =  226 bits (576), Expect = 9e-59
 Identities = 171/591 (28%), Positives = 274/591 (46%), Gaps = 67/591 (11%)

Query: 524  CSATGREKPTIKWERADGSSLPEW------VTDNAGTLHFARVTRDDAGNYTCIASNGPQ 577
            C A G   PT++W +       E       V +   +L    V   D GNYTC+  N   
Sbjct: 64   CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN-EY 122

Query: 578  GQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRI 631
            G I     L V         +   +    +TV  G    + C+   D +P IQW  K   
Sbjct: 123  GSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-CKVYSDAQPHIQWI-KHVE 180

Query: 632  LDPTKLGPR----MHIFQNGS----------LVIHDVAPEDSGRYTCIAGNSCNIKHTEA 677
             + +K GP     + + +             L I +V  ED+G YTC+AGNS  I    A
Sbjct: 181  KNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSA 240

Query: 678  PLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQK 737
             L V+  P P   +   + P Y  I    + V      ++ V+         C+ K   K
Sbjct: 241  WLTVL--PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVI--------LCRMKNTTK 290

Query: 738  QPE-GEEPEMECLNGGPLQNGQPSAEIQEE-------VALTSLGSGPAATNKRHSTSD-- 787
            +P+   +P +  L        Q SAE           V +T+  S  A T      S+  
Sbjct: 291  KPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYE 350

Query: 788  -----KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLD 842
                 K  FPR  L     LG+  FG+V +A+A G+++   +  V V     KD+  + D
Sbjct: 351  LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 410

Query: 843  FR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD---- 894
                  E+EM   +  H N++ LLG C +  P Y+++EY   G+L+++LR  +       
Sbjct: 411  LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS 470

Query: 895  ---EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGL 951
                ++  + ++ K  V+   Q+A GME+L++ + +H+DLAARN LV+    +K++  GL
Sbjct: 471  YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL 530

Query: 952  SKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQ 1010
            ++D+ N +YY       +P++WM+PEA+ +  ++ +SDVW+FGVLMWE+FT G  P+ G 
Sbjct: 531  ARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI 590

Query: 1011 ADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
              +E+   L+ G  R+ +P  C ++LY +M+ CW   P  RP+F ++   L
Sbjct: 591  PVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 640



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 2/85 (2%)

Query: 593 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 651
           T K+E     V   +T   +C A G+P P ++W K         ++G      Q+ SL++
Sbjct: 44  TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 103

Query: 652 HDVAPEDSGRYTCIAGNSC-NIKHT 675
             V P D G YTC+  N   +I HT
Sbjct: 104 ESVVPSDKGNYTCVVENEYGSINHT 128



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 7/119 (5%)

Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
           V  RC   G+P PT +W ++G           + V ++  +L +    P   G Y+C   
Sbjct: 60  VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 119

Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
           + +G    +  + L + + S  R +L    P +       +  F C+  +   P +QW+
Sbjct: 120 NEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 176



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 43/170 (25%), Positives = 63/170 (37%), Gaps = 30/170 (17%)

Query: 433 CLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAG 488
           C     P PT+ W +N     ++ R   +K    + +L + SV   D   Y C+     G
Sbjct: 64  CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYG 123

Query: 489 SIEAQARVQVLEKLKFTP------PPQPQQCMEFDKEATVPCSATGREKPTIKW----ER 538
           SI     + V+E+    P      P      +  D E    C      +P I+W    E+
Sbjct: 124 SINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV--CKVYSDAQPHIQWIKHVEK 181

Query: 539 ADGSSLPEW-----VTDNAG---------TLHFARVTRDDAGNYTCIASN 574
                 P+      V   AG          L+   VT +DAG YTC+A N
Sbjct: 182 NGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGN 231


>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform 1
            [Homo sapiens]
          Length = 790

 Score =  226 bits (575), Expect = 1e-58
 Identities = 161/536 (30%), Positives = 254/536 (47%), Gaps = 38/536 (7%)

Query: 555  LHFARVTRD-DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC 613
            L  A VT D +  N TC A N          +++V V ++F    +  T  + H   +  
Sbjct: 249  LTLANVTSDLNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPF 303

Query: 614  EAQGDPKPLIQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIA 666
               G P P ++W     +L+ T       L P  +   ++G L ++     ++G YT +A
Sbjct: 304  SVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLA 363

Query: 667  GNSCNIKHTEAPLYVVDKP--------VPEESEGPGSPPPYKMIQTIGLSVGAAVA---- 714
             N             +D P        +P+ +   G P   K     G+SV   +A    
Sbjct: 364  ANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFAC 423

Query: 715  -YIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLG 773
             ++  +L ++  C +R K      +P    PE              S+    E   + L 
Sbjct: 424  LFLSTLLLVLNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQ 481

Query: 774  SGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQ 833
                   +  S +   H  R  +     LG+  FG+VFLA+   L     + LV VK+L+
Sbjct: 482  GHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 541

Query: 834  SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSK 893
               E  + DF+RE E+   L H ++VR  G+C E  P  MV EY+  GDL +FLR S   
Sbjct: 542  EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR-SHGP 600

Query: 894  DEKLKS-------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKV 946
            D KL +        PL   Q +A+ +QVA GM +L+   FVH+DLA RNCLV     VK+
Sbjct: 601  DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 660

Query: 947  SALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEM 1005
               G+S+D+Y+++YY    +  +P+RWM PE+IL   F+T+SDVW+FGV++WE+FT+G+ 
Sbjct: 661  GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 720

Query: 1006 PHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
            P    ++ E +  +  G+  L +P  CP ++Y +M+ CW   P+ R S  ++ + L
Sbjct: 721  PWYQLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 775



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)

Query: 46  GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
           G   LLRC+VE  G     W+L       T  +     SL     +   D       C A
Sbjct: 208 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 267

Query: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
            +DV   E +   N SF              PAS   +Q  T V +        +DG P 
Sbjct: 268 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 310

Query: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
           P+ +W  +G+ L++     T       +   R+  LR   P H  +G Y+  A + FGQA
Sbjct: 311 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 370

Query: 210 CSS 212
            +S
Sbjct: 371 SAS 373


>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform 3
            [Homo sapiens]
          Length = 760

 Score =  226 bits (575), Expect = 1e-58
 Identities = 161/536 (30%), Positives = 254/536 (47%), Gaps = 38/536 (7%)

Query: 555  LHFARVTRD-DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC 613
            L  A VT D +  N TC A N          +++V V ++F    +  T  + H   +  
Sbjct: 219  LTLANVTSDLNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPF 273

Query: 614  EAQGDPKPLIQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIA 666
               G P P ++W     +L+ T       L P  +   ++G L ++     ++G YT +A
Sbjct: 274  SVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLA 333

Query: 667  GNSCNIKHTEAPLYVVDKP--------VPEESEGPGSPPPYKMIQTIGLSVGAAVA---- 714
             N             +D P        +P+ +   G P   K     G+SV   +A    
Sbjct: 334  ANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFAC 393

Query: 715  -YIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLG 773
             ++  +L ++  C +R K      +P    PE              S+    E   + L 
Sbjct: 394  LFLSTLLLVLNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQ 451

Query: 774  SGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQ 833
                   +  S +   H  R  +     LG+  FG+VFLA+   L     + LV VK+L+
Sbjct: 452  GHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 511

Query: 834  SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSK 893
               E  + DF+RE E+   L H ++VR  G+C E  P  MV EY+  GDL +FLR S   
Sbjct: 512  EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR-SHGP 570

Query: 894  DEKLKS-------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKV 946
            D KL +        PL   Q +A+ +QVA GM +L+   FVH+DLA RNCLV     VK+
Sbjct: 571  DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 630

Query: 947  SALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEM 1005
               G+S+D+Y+++YY    +  +P+RWM PE+IL   F+T+SDVW+FGV++WE+FT+G+ 
Sbjct: 631  GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 690

Query: 1006 PHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
            P    ++ E +  +  G+  L +P  CP ++Y +M+ CW   P+ R S  ++ + L
Sbjct: 691  PWYQLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 745



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)

Query: 46  GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
           G   LLRC+VE  G     W+L       T  +     SL     +   D       C A
Sbjct: 178 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 237

Query: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
            +DV   E +   N SF              PAS   +Q  T V +        +DG P 
Sbjct: 238 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 280

Query: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
           P+ +W  +G+ L++     T       +   R+  LR   P H  +G Y+  A + FGQA
Sbjct: 281 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 340

Query: 210 CSS 212
            +S
Sbjct: 341 SAS 343


>gi|222144237 fibroblast growth factor receptor 2 isoform 6 precursor
            [Homo sapiens]
          Length = 706

 Score =  225 bits (573), Expect = 2e-58
 Identities = 167/593 (28%), Positives = 273/593 (46%), Gaps = 69/593 (11%)

Query: 524  CSATGREKPTIKWERADGSSLPEW------VTDNAGTLHFARVTRDDAGNYTCIASNGPQ 577
            C A G   PT++W +       E       V +   +L    V   D GNYTC+  N   
Sbjct: 64   CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN-EY 122

Query: 578  GQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRI 631
            G I     L V         +   +    +TV  G    + C+   D +P IQW  K   
Sbjct: 123  GSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-CKVYSDAQPHIQWI-KHVE 180

Query: 632  LDPTKLGPR----MHIFQNGS----------LVIHDVAPEDSGRYTCIAGNSCNIKHTEA 677
             + +K GP     + + +             L I +V  ED+G YTC+AGNS  I    A
Sbjct: 181  KNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSA 240

Query: 678  PLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQK 737
             L V+  P P   +   + P Y  I    + V      ++ V+         C+ K   K
Sbjct: 241  WLTVL--PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVI--------LCRMKNTTK 290

Query: 738  QPE-GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD--------- 787
            +P+   +P +  L        Q +   +   ++ S       T +  ST+D         
Sbjct: 291  KPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSE 350

Query: 788  -------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 840
                   K  FPR  L     LG+  FG+V +A+A G+++   +  V V     KD+  +
Sbjct: 351  YELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATE 410

Query: 841  LDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-- 894
             D      E+EM   +  H N++ LLG C +  P Y+++EY   G+L+++LR  +     
Sbjct: 411  KDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGME 470

Query: 895  -----EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSAL 949
                  ++  + ++ K  V+   Q+A GME+L++ + +H+DLAARN LV+    +K++  
Sbjct: 471  YSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADF 530

Query: 950  GLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHG 1008
            GL++D+ N +YY       +P++WM+PEA+ +  ++ +SDVW+FGVLMWE+FT G  P+ 
Sbjct: 531  GLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYP 590

Query: 1009 GQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
            G   +E+   L+ G  R+ +P  C ++LY +M+ CW   P  RP+F ++   L
Sbjct: 591  GIPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 642



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 2/85 (2%)

Query: 593 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 651
           T K+E     V   +T   +C A G+P P ++W K         ++G      Q+ SL++
Sbjct: 44  TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 103

Query: 652 HDVAPEDSGRYTCIAGNSC-NIKHT 675
             V P D G YTC+  N   +I HT
Sbjct: 104 ESVVPSDKGNYTCVVENEYGSINHT 128



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 7/119 (5%)

Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
           V  RC   G+P PT +W ++G           + V ++  +L +    P   G Y+C   
Sbjct: 60  VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 119

Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
           + +G    +  + L + + S  R +L    P +       +  F C+  +   P +QW+
Sbjct: 120 NEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 176



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 43/170 (25%), Positives = 63/170 (37%), Gaps = 30/170 (17%)

Query: 433 CLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAG 488
           C     P PT+ W +N     ++ R   +K    + +L + SV   D   Y C+     G
Sbjct: 64  CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYG 123

Query: 489 SIEAQARVQVLEKLKFTP------PPQPQQCMEFDKEATVPCSATGREKPTIKW----ER 538
           SI     + V+E+    P      P      +  D E    C      +P I+W    E+
Sbjct: 124 SINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV--CKVYSDAQPHIQWIKHVEK 181

Query: 539 ADGSSLPEW-----VTDNAG---------TLHFARVTRDDAGNYTCIASN 574
                 P+      V   AG          L+   VT +DAG YTC+A N
Sbjct: 182 NGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGN 231


>gi|222144235 fibroblast growth factor receptor 2 isoform 5 precursor
            [Homo sapiens]
          Length = 707

 Score =  225 bits (573), Expect = 2e-58
 Identities = 167/593 (28%), Positives = 273/593 (46%), Gaps = 69/593 (11%)

Query: 524  CSATGREKPTIKWERADGSSLPEW------VTDNAGTLHFARVTRDDAGNYTCIASNGPQ 577
            C A G   PT++W +       E       V +   +L    V   D GNYTC+  N   
Sbjct: 90   CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN-EY 148

Query: 578  GQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRI 631
            G I     L V         +   +    +TV  G    + C+   D +P IQW  K   
Sbjct: 149  GSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-CKVYSDAQPHIQWI-KHVE 206

Query: 632  LDPTKLGPR----MHIFQNGS----------LVIHDVAPEDSGRYTCIAGNSCNIKHTEA 677
             + +K GP     + + +             L I +V  ED+G YTC+AGNS  I    A
Sbjct: 207  KNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSA 266

Query: 678  PLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQK 737
             L V+  P P   +   + P Y  I    + V      ++ V+         C+ K   K
Sbjct: 267  WLTVL--PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVI--------LCRMKNTTK 316

Query: 738  QPE-GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD--------- 787
            +P+   +P +  L        Q +   +   ++ S       T +  ST+D         
Sbjct: 317  KPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSE 376

Query: 788  -------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 840
                   K  FPR  L     LG+  FG+V +A+A G+++   +  V V     KD+  +
Sbjct: 377  YELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATE 436

Query: 841  LDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-- 894
             D      E+EM   +  H N++ LLG C +  P Y+++EY   G+L+++LR  +     
Sbjct: 437  KDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGME 496

Query: 895  -----EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSAL 949
                  ++  + ++ K  V+   Q+A GME+L++ + +H+DLAARN LV+    +K++  
Sbjct: 497  YSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADF 556

Query: 950  GLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHG 1008
            GL++D+ N +YY       +P++WM+PEA+ +  ++ +SDVW+FGVLMWE+FT G  P+ 
Sbjct: 557  GLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYP 616

Query: 1009 GQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
            G   +E+   L+ G  R+ +P  C ++LY +M+ CW   P  RP+F ++   L
Sbjct: 617  GIPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 668



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 2/85 (2%)

Query: 593 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 651
           T K+E     V   +T   +C A G+P P ++W K         ++G      Q+ SL++
Sbjct: 70  TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 129

Query: 652 HDVAPEDSGRYTCIAGNSC-NIKHT 675
             V P D G YTC+  N   +I HT
Sbjct: 130 ESVVPSDKGNYTCVVENEYGSINHT 154



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 7/119 (5%)

Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
           V  RC   G+P PT +W ++G           + V ++  +L +    P   G Y+C   
Sbjct: 86  VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 145

Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
           + +G    +  + L + + S  R +L    P +       +  F C+  +   P +QW+
Sbjct: 146 NEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 202



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 43/170 (25%), Positives = 63/170 (37%), Gaps = 30/170 (17%)

Query: 433 CLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAG 488
           C     P PT+ W +N     ++ R   +K    + +L + SV   D   Y C+     G
Sbjct: 90  CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYG 149

Query: 489 SIEAQARVQVLEKLKFTP------PPQPQQCMEFDKEATVPCSATGREKPTIKW----ER 538
           SI     + V+E+    P      P      +  D E    C      +P I+W    E+
Sbjct: 150 SINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV--CKVYSDAQPHIQWIKHVEK 207

Query: 539 ADGSSLPEW-----VTDNAG---------TLHFARVTRDDAGNYTCIASN 574
                 P+      V   AG          L+   VT +DAG YTC+A N
Sbjct: 208 NGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGN 257


>gi|221316639 fibroblast growth factor receptor 2 isoform 1 precursor
            [Homo sapiens]
          Length = 821

 Score =  225 bits (573), Expect = 2e-58
 Identities = 167/593 (28%), Positives = 273/593 (46%), Gaps = 69/593 (11%)

Query: 524  CSATGREKPTIKWERADGSSLPEW------VTDNAGTLHFARVTRDDAGNYTCIASNGPQ 577
            C A G   PT++W +       E       V +   +L    V   D GNYTC+  N   
Sbjct: 179  CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN-EY 237

Query: 578  GQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRI 631
            G I     L V         +   +    +TV  G    + C+   D +P IQW  K   
Sbjct: 238  GSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-CKVYSDAQPHIQWI-KHVE 295

Query: 632  LDPTKLGPR----MHIFQNGS----------LVIHDVAPEDSGRYTCIAGNSCNIKHTEA 677
             + +K GP     + + +             L I +V  ED+G YTC+AGNS  I    A
Sbjct: 296  KNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSA 355

Query: 678  PLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQK 737
             L V+  P P   +   + P Y  I    + V      ++ V+         C+ K   K
Sbjct: 356  WLTVL--PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVI--------LCRMKNTTK 405

Query: 738  QPE-GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD--------- 787
            +P+   +P +  L        Q +   +   ++ S       T +  ST+D         
Sbjct: 406  KPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSE 465

Query: 788  -------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 840
                   K  FPR  L     LG+  FG+V +A+A G+++   +  V V     KD+  +
Sbjct: 466  YELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATE 525

Query: 841  LDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-- 894
             D      E+EM   +  H N++ LLG C +  P Y+++EY   G+L+++LR  +     
Sbjct: 526  KDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGME 585

Query: 895  -----EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSAL 949
                  ++  + ++ K  V+   Q+A GME+L++ + +H+DLAARN LV+    +K++  
Sbjct: 586  YSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADF 645

Query: 950  GLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHG 1008
            GL++D+ N +YY       +P++WM+PEA+ +  ++ +SDVW+FGVLMWE+FT G  P+ 
Sbjct: 646  GLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYP 705

Query: 1009 GQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
            G   +E+   L+ G  R+ +P  C ++LY +M+ CW   P  RP+F ++   L
Sbjct: 706  GIPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 757



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)

Query: 35  IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
           I QP    A  G    +RC ++    +   W  DG  +    R    G  L        +
Sbjct: 44  ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100

Query: 95  DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
           DSG + C A                         DD  G E   +  S N +   W    
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160

Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
            +  +  A  A       V  RC   G+P PT +W ++G           + V ++  +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216

Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
            +    P   G Y+C   + +G    +  + L + + S  R +L    P +       + 
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274

Query: 243 MFHCQFSAQPPPSLQWL 259
            F C+  +   P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 71/307 (23%), Positives = 103/307 (33%), Gaps = 67/307 (21%)

Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
           +P V+ A  G    V CL    L + +V  W   GV L  + R    G  L +      D
Sbjct: 46  QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101

Query: 386 AGVYTCHAANLAGQRRQD--VNITVAT------------------------VPSWLKKPQ 419
           +G+Y C A+           VN+T A                          P W    +
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEK 161

Query: 420 DSQLEEGKPGY----LDCLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSV 471
             +     P        C     P PT+ W +N     ++ R   +K    + +L + SV
Sbjct: 162 MEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESV 221

Query: 472 EVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTP------PPQPQQCMEFDKEATVPCS 525
              D   Y C+     GSI     + V+E+    P      P      +  D E    C 
Sbjct: 222 VPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV--CK 279

Query: 526 ATGREKPTIKW----ERADGSSLPEW-----VTDNAG---------TLHFARVTRDDAGN 567
                +P I+W    E+      P+      V   AG          L+   VT +DAG 
Sbjct: 280 VYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGE 339

Query: 568 YTCIASN 574
           YTC+A N
Sbjct: 340 YTCLAGN 346



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 2/85 (2%)

Query: 593 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 651
           T K+E     V   +T   +C A G+P P ++W K         ++G      Q+ SL++
Sbjct: 159 TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 218

Query: 652 HDVAPEDSGRYTCIAGNSC-NIKHT 675
             V P D G YTC+  N   +I HT
Sbjct: 219 ESVVPSDKGNYTCVVENEYGSINHT 243



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 79/343 (23%), Positives = 118/343 (34%), Gaps = 82/343 (23%)

Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
           K+  S+ E+    P   + +RC +         W +DG  L  G +N TV   E  L ++
Sbjct: 41  KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95

Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
            A P  SGLY+C A         +  F +++ D              E F    +    A
Sbjct: 96  GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153

Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
           P      + E+ +          F C     P P+++WL     F+ E  I   + R  H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213

Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP-------- 326
                     SL++  V P + G Y C+ + + G    +  T HL  +E  P        
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSPHRPILQAG 261

Query: 327 LFEPRVFTAGSEERVTCLPPKGLPEPSVWW----EHAGVRLPTHGRVYQKG--------- 373
           L        G +    C       +P + W    E  G +    G  Y K          
Sbjct: 262 LPANASTVVGGDVEFVCKVYSD-AQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTT 320

Query: 374 ----HELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVP 412
                 L + N+   DAG YTC A N  G       +TV   P
Sbjct: 321 DKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAP 363


>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform a
            precursor [Homo sapiens]
          Length = 838

 Score =  224 bits (571), Expect = 3e-58
 Identities = 178/628 (28%), Positives = 284/628 (45%), Gaps = 84/628 (13%)

Query: 510  PQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNA-GTLHFARVTRDDAGNY 568
            P   +E  K  T+ CS  G   P + W+  +  S     T +  G+L    ++ DD+G  
Sbjct: 204  PNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQ 263

Query: 569  -TCIASNGPQGQIRAHVQLTV--AVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW 625
             +C+A N   G+ +  V LTV  A  ITF   P        H   +    +G+PKP +QW
Sbjct: 264  ISCVAEN-LVGEDQDSVNLTVHFAPTITFLESPT-----SDHHWCIPFTVKGNPKPALQW 317

Query: 626  KGKDRILDP-----TKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLY 680
                 IL+      TK+    H   +G L + +    ++G YT IA N       +   +
Sbjct: 318  FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH 377

Query: 681  VVDKPVPEESEGPGSPPP-YKMIQTIGLSVGA-------------------------AVA 714
             +  P  ++   P  P   Y+   T    +G                          AV 
Sbjct: 378  FMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVV 437

Query: 715  YIIAVLG----LMFYCKKRCKAKRLQ------------KQPEGEEPEMECLN----GGPL 754
             I +V+G    +M +  K  +  +              K  +G  P     N      PL
Sbjct: 438  VIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPL 497

Query: 755  Q------NGQPSAEIQEEVALTSLGSGPAATNKRHS--TSDKM-------HFPRSSLQPI 799
                   N   S+E   +  +  +   P   N ++   T+ ++       H  R ++   
Sbjct: 498  HHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLK 557

Query: 800  TTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVV 859
              LG+  FG+VFLA+   L     + LV VK+L+   +  + DF RE E+   L H ++V
Sbjct: 558  RELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIV 617

Query: 860  RLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ-----PLSTKQKVALCTQV 914
            +  G+C E +P  MV EY+  GDL +FLR +   D  L ++      L+  Q + +  Q+
Sbjct: 618  KFYGVCVEGDPLIMVFEYMKHGDLNKFLR-AHGPDAVLMAEGNPPTELTQSQMLHIAQQI 676

Query: 915  ALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWM 973
            A GM +L++  FVH+DLA RNCLV     VK+   G+S+DVY+++YY       +P+RWM
Sbjct: 677  AAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWM 736

Query: 974  SPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCP 1033
             PE+I+   F+T+SDVW+ GV++WE+FT+G+ P    +++EV+  +  G+  L +P  CP
Sbjct: 737  PPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRV-LQRPRTCP 795

Query: 1034 SKLYRLMQRCWALSPKDRPSFSEIASAL 1061
             ++Y LM  CW   P  R +   I + L
Sbjct: 796  QEVYELMLGCWQREPHMRKNIKGIHTLL 823



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 45/176 (25%), Positives = 67/176 (38%), Gaps = 21/176 (11%)

Query: 423 LEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYD-GTWYRC 481
           +EEGK   L C     P P + W     L+S+         G+LRI ++   D G    C
Sbjct: 208 VEEGKSITLSCSVAGDPVPNMYWDVGN-LVSKHMNETSHTQGSLRITNISSDDSGKQISC 266

Query: 482 MSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADG 541
           ++    G  +    + V     F P     +    D    +P +  G  KP ++W   +G
Sbjct: 267 VAENLVGEDQDSVNLTV----HFAPTITFLESPTSDHHWCIPFTVKGNPKPALQW-FYNG 321

Query: 542 SSLPEWV-----------TDNAGTLHFARVTRDDAGNYTCIASN---GPQGQIRAH 583
           + L E             T+  G L     T  + G+YT IA N     + QI AH
Sbjct: 322 AILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH 377



 Score = 37.4 bits (85), Expect = 0.076
 Identities = 36/172 (20%), Positives = 68/172 (39%), Gaps = 20/172 (11%)

Query: 45  QGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVAR 104
           +G+   L C V      ++YW +     +          SL    +          CVA 
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVA- 268

Query: 105 DDVTGEEARSANASFNIKWIEAGPVV--LKHPASEAEIQPQTQVTLRCHIDGHPRPTYQW 162
           +++ GE+  S N +     +   P +  L+ P S+          +   + G+P+P  QW
Sbjct: 269 ENLVGEDQDSVNLT-----VHFAPTITFLESPTSDHHW------CIPFTVKGNPKPALQW 317

Query: 163 FRDGTPLSDGQ----SNHTVSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQ 208
           F +G  L++ +      H  +  E +  L+   P H  +G Y+  A + +G+
Sbjct: 318 FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK 369



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 44/179 (24%), Positives = 66/179 (36%), Gaps = 18/179 (10%)

Query: 135 ASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEH 194
           A    ++    +TL C + G P P   W  D   L     N T S  + +L +     + 
Sbjct: 203 APNLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNET-SHTQGSLRITNISSDD 259

Query: 195 SG-LYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPP 253
           SG   SC A +  G+   S N T+      FA  +   +      +    F       P 
Sbjct: 260 SGKQISCVAENLVGEDQDSVNLTV-----HFAPTITFLESPTSDHHWCIPF--TVKGNPK 312

Query: 254 PSLQWLFEDETPITNRSR----PPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
           P+LQW +     I N S+      H+   T + +G L L      N G Y  I + + G
Sbjct: 313 PALQWFYNG--AILNESKYICTKIHVTNHTEY-HGCLQLDNPTHMNNGDYTLIAKNEYG 368


>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
            [Homo sapiens]
          Length = 802

 Score =  224 bits (571), Expect = 3e-58
 Identities = 174/580 (30%), Positives = 280/580 (48%), Gaps = 50/580 (8%)

Query: 524  CSATGREKPTIKWERADGSSLPEW-------VTDNAGTLHFARVTRDDAGNYTCIASNGP 576
            C A G   PTI+W + DG +           +     +L    V   D G YTC+  N  
Sbjct: 172  CPAAGNPTPTIRWLK-DGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAV 230

Query: 577  QGQIRAHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRI 631
             G IR +  L V      +       P  TT   G    L C+   D +P IQW  K  +
Sbjct: 231  -GSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWL-KHIV 288

Query: 632  LDPTKLG----PRMHIFQNGS--------LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPL 679
            ++ +  G    P + + +           L + +V+ ED+G YTC+AGNS  + +  A L
Sbjct: 289  INGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWL 348

Query: 680  YVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL--GLMFYCKKRCKAKRLQK 737
             V+ +  P  +          +I     S+  AV  ++A L  G   + +       +QK
Sbjct: 349  TVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQK 408

Query: 738  QPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKM----HFPR 793
                       L  G   +G+ S+ +   V L+S  SGPA      S    +     FPR
Sbjct: 409  LSRFPLARQFSLESG--SSGKSSSSLVRGVRLSS--SGPALLAGLVSLDLPLDPLWEFPR 464

Query: 794  SSLQPITTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMF 850
              L     LG+  FG+V  A+A G++    +  + V VK L+     + L D   E+E+ 
Sbjct: 465  DRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVM 524

Query: 851  GKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK------SKDEKLKSQ-PL 902
              +  H N++ LLG+C +  P Y+++E    G+L++FLR  +      S D    S+ PL
Sbjct: 525  KLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPL 584

Query: 903  STKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH 962
            S    V+   QVA GM++L + + +H+DLAARN LV+    +K++  GL++ V++ +YY 
Sbjct: 585  SFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYK 644

Query: 963  -FRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQA 1021
                  +P++WM+PEA+ +  ++ +SDVW+FG+L+WE+FT G  P+ G   +E+ + L+ 
Sbjct: 645  KTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLRE 704

Query: 1022 GKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
            G  R+ +P  CP +LY LM+ CW  +P  RP+F ++  AL
Sbjct: 705  GH-RMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL 743



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 76/330 (23%), Positives = 110/330 (33%), Gaps = 71/330 (21%)

Query: 308 GPPII-LEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPK----GLPEPSVWWEHAGVR 362
           GPP++ LEA+    E+E  P   P +     E  V    P     G  E    W   G R
Sbjct: 16  GPPVLSLEAS---EEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSR 72

Query: 363 LPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQ 422
           L   GRV      L +A+    DAG Y C A    G      N+T+ T  S      D  
Sbjct: 73  LAPAGRVRGWRGRLEIASFLPEDAGRYLCLAR---GSMIVLQNLTLITGDSLTSSNDDED 129

Query: 423 --------------------------------LEEGKPGYLDCLTQATPKPTVVWYRNQM 450
                                           +  G      C     P PT+ W ++  
Sbjct: 130 PKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQ 189

Query: 451 LISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTP 506
               ++R    +    + +L + SV   D   Y C+     GSI     + VLE+    P
Sbjct: 190 AFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRP 249

Query: 507 ------PPQPQQCMEFDKEATVPCSATGREKPTIKWER----------ADGSSLPEWV-- 548
                 P      +  D E  + C      +P I+W +          ADG    + +  
Sbjct: 250 ILQAGLPANTTAVVGSDVE--LLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKT 307

Query: 549 ----TDNAGTLHFARVTRDDAGNYTCIASN 574
               +     L+   V+ +DAG YTC+A N
Sbjct: 308 ADINSSEVEVLYLRNVSAEDAGEYTCLAGN 337



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 25/76 (32%), Positives = 38/76 (50%), Gaps = 1/76 (1%)

Query: 595 KVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVIHD 653
           ++E +   V  G+T   +C A G+P P I+W K         ++G      Q+ SLV+  
Sbjct: 154 RMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMES 213

Query: 654 VAPEDSGRYTCIAGNS 669
           V P D G YTC+  N+
Sbjct: 214 VVPSDRGTYTCLVENA 229



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 46/212 (21%), Positives = 74/212 (34%), Gaps = 26/212 (12%)

Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKER--NLTLRPAGPEHSGLYSCCAH 203
           V  RC   G+P PT +W +DG           +  + +  +L +    P   G Y+C   
Sbjct: 168 VKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVE 227

Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWLF 260
           +A G      N+ L + + S  R +L    P +       +    C+  +   P +QWL 
Sbjct: 228 NAVGSI--RYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLK 285

Query: 261 E----------DETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPP 310
                      D  P     +   +  + V     L L  V   +AG Y C+     G  
Sbjct: 286 HIVINGSSFGADGFPYVQVLKTADINSSEVEV---LYLRNVSAEDAGEYTCLAGNSIG-- 340

Query: 311 IILEATLHLAEIEDMPLFEPRVFTAGSEERVT 342
                +   A +  +P  +P    A  E R T
Sbjct: 341 ----LSYQSAWLTVLPEEDPTWTAAAPEARYT 368



 Score = 38.5 bits (88), Expect = 0.034
 Identities = 46/198 (23%), Positives = 72/198 (36%), Gaps = 43/198 (21%)

Query: 335 AGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHG-------RVYQKGHELVLANIAESDAG 387
           AG+  +  C P  G P P++ W   G     HG       R+  +   LV+ ++  SD G
Sbjct: 164 AGNTVKFRC-PAAGNPTPTIRWLKDGQAF--HGENRIGGIRLRHQHWSLVMESVVPSDRG 220

Query: 388 VYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPG----------YLDCLTQA 437
            YTC   N  G  R +  + V       + P    L+ G P            L C   +
Sbjct: 221 TYTCLVENAVGSIRYNYLLDVLE-----RSPHRPILQAGLPANTTAVVGSDVELLCKVYS 275

Query: 438 TPKPTVVWYRNQMLISEDSRF--------EVFKNGTLRINSVEVY--------DGTWYRC 481
             +P + W ++  ++   S F        +V K   +  + VEV         D   Y C
Sbjct: 276 DAQPHIQWLKH--IVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTC 333

Query: 482 MSSTPAGSIEAQARVQVL 499
           ++    G     A + VL
Sbjct: 334 LAGNSIGLSYQSAWLTVL 351



 Score = 38.5 bits (88), Expect = 0.034
 Identities = 46/194 (23%), Positives = 73/194 (37%), Gaps = 28/194 (14%)

Query: 244 FHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIG 303
           F C  +  P P+++WL +D       +R   +R      + SL++  V P + G Y C+ 
Sbjct: 170 FRCPAAGNPTPTIRWL-KDGQAFHGENRIGGIRLR--HQHWSLVMESVVPSDRGTYTCLV 226

Query: 304 QGQRGPPI------ILEATLHLAEIE-DMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWW 356
           +   G         +LE + H   ++  +P     V   GS+  + C           W 
Sbjct: 227 ENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV--VGSDVELLCKVYSDAQPHIQWL 284

Query: 357 EHAGVR--------------LPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQ 402
           +H  +               L T      +   L L N++  DAG YTC A N  G   Q
Sbjct: 285 KHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQ 344

Query: 403 DVNITVATV--PSW 414
              +TV     P+W
Sbjct: 345 SAWLTVLPEEDPTW 358


>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
            [Homo sapiens]
          Length = 802

 Score =  224 bits (571), Expect = 3e-58
 Identities = 174/580 (30%), Positives = 280/580 (48%), Gaps = 50/580 (8%)

Query: 524  CSATGREKPTIKWERADGSSLPEW-------VTDNAGTLHFARVTRDDAGNYTCIASNGP 576
            C A G   PTI+W + DG +           +     +L    V   D G YTC+  N  
Sbjct: 172  CPAAGNPTPTIRWLK-DGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAV 230

Query: 577  QGQIRAHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRI 631
             G IR +  L V      +       P  TT   G    L C+   D +P IQW  K  +
Sbjct: 231  -GSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWL-KHIV 288

Query: 632  LDPTKLG----PRMHIFQNGS--------LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPL 679
            ++ +  G    P + + +           L + +V+ ED+G YTC+AGNS  + +  A L
Sbjct: 289  INGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWL 348

Query: 680  YVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL--GLMFYCKKRCKAKRLQK 737
             V+ +  P  +          +I     S+  AV  ++A L  G   + +       +QK
Sbjct: 349  TVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQK 408

Query: 738  QPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKM----HFPR 793
                       L  G   +G+ S+ +   V L+S  SGPA      S    +     FPR
Sbjct: 409  LSRFPLARQFSLESG--SSGKSSSSLVRGVRLSS--SGPALLAGLVSLDLPLDPLWEFPR 464

Query: 794  SSLQPITTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMF 850
              L     LG+  FG+V  A+A G++    +  + V VK L+     + L D   E+E+ 
Sbjct: 465  DRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVM 524

Query: 851  GKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK------SKDEKLKSQ-PL 902
              +  H N++ LLG+C +  P Y+++E    G+L++FLR  +      S D    S+ PL
Sbjct: 525  KLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPL 584

Query: 903  STKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH 962
            S    V+   QVA GM++L + + +H+DLAARN LV+    +K++  GL++ V++ +YY 
Sbjct: 585  SFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYK 644

Query: 963  -FRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQA 1021
                  +P++WM+PEA+ +  ++ +SDVW+FG+L+WE+FT G  P+ G   +E+ + L+ 
Sbjct: 645  KTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLRE 704

Query: 1022 GKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
            G  R+ +P  CP +LY LM+ CW  +P  RP+F ++  AL
Sbjct: 705  GH-RMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL 743



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 76/330 (23%), Positives = 110/330 (33%), Gaps = 71/330 (21%)

Query: 308 GPPII-LEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPK----GLPEPSVWWEHAGVR 362
           GPP++ LEA+    E+E  P   P +     E  V    P     G  E    W   G R
Sbjct: 16  GPPVLSLEAS---EEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSR 72

Query: 363 LPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQ 422
           L   GRV      L +A+    DAG Y C A    G      N+T+ T  S      D  
Sbjct: 73  LAPAGRVRGWRGRLEIASFLPEDAGRYLCLAR---GSMIVLQNLTLITGDSLTSSNDDED 129

Query: 423 --------------------------------LEEGKPGYLDCLTQATPKPTVVWYRNQM 450
                                           +  G      C     P PT+ W ++  
Sbjct: 130 PKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQ 189

Query: 451 LISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTP 506
               ++R    +    + +L + SV   D   Y C+     GSI     + VLE+    P
Sbjct: 190 AFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRP 249

Query: 507 ------PPQPQQCMEFDKEATVPCSATGREKPTIKWER----------ADGSSLPEWV-- 548
                 P      +  D E  + C      +P I+W +          ADG    + +  
Sbjct: 250 ILQAGLPANTTAVVGSDVE--LLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKT 307

Query: 549 ----TDNAGTLHFARVTRDDAGNYTCIASN 574
               +     L+   V+ +DAG YTC+A N
Sbjct: 308 ADINSSEVEVLYLRNVSAEDAGEYTCLAGN 337



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 25/76 (32%), Positives = 38/76 (50%), Gaps = 1/76 (1%)

Query: 595 KVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVIHD 653
           ++E +   V  G+T   +C A G+P P I+W K         ++G      Q+ SLV+  
Sbjct: 154 RMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMES 213

Query: 654 VAPEDSGRYTCIAGNS 669
           V P D G YTC+  N+
Sbjct: 214 VVPSDRGTYTCLVENA 229



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 46/212 (21%), Positives = 74/212 (34%), Gaps = 26/212 (12%)

Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKER--NLTLRPAGPEHSGLYSCCAH 203
           V  RC   G+P PT +W +DG           +  + +  +L +    P   G Y+C   
Sbjct: 168 VKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVE 227

Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWLF 260
           +A G      N+ L + + S  R +L    P +       +    C+  +   P +QWL 
Sbjct: 228 NAVGSI--RYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLK 285

Query: 261 E----------DETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPP 310
                      D  P     +   +  + V     L L  V   +AG Y C+     G  
Sbjct: 286 HIVINGSSFGADGFPYVQVLKTADINSSEVEV---LYLRNVSAEDAGEYTCLAGNSIG-- 340

Query: 311 IILEATLHLAEIEDMPLFEPRVFTAGSEERVT 342
                +   A +  +P  +P    A  E R T
Sbjct: 341 ----LSYQSAWLTVLPEEDPTWTAAAPEARYT 368



 Score = 38.5 bits (88), Expect = 0.034
 Identities = 46/198 (23%), Positives = 72/198 (36%), Gaps = 43/198 (21%)

Query: 335 AGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHG-------RVYQKGHELVLANIAESDAG 387
           AG+  +  C P  G P P++ W   G     HG       R+  +   LV+ ++  SD G
Sbjct: 164 AGNTVKFRC-PAAGNPTPTIRWLKDGQAF--HGENRIGGIRLRHQHWSLVMESVVPSDRG 220

Query: 388 VYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPG----------YLDCLTQA 437
            YTC   N  G  R +  + V       + P    L+ G P            L C   +
Sbjct: 221 TYTCLVENAVGSIRYNYLLDVLE-----RSPHRPILQAGLPANTTAVVGSDVELLCKVYS 275

Query: 438 TPKPTVVWYRNQMLISEDSRF--------EVFKNGTLRINSVEVY--------DGTWYRC 481
             +P + W ++  ++   S F        +V K   +  + VEV         D   Y C
Sbjct: 276 DAQPHIQWLKH--IVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTC 333

Query: 482 MSSTPAGSIEAQARVQVL 499
           ++    G     A + VL
Sbjct: 334 LAGNSIGLSYQSAWLTVL 351



 Score = 38.5 bits (88), Expect = 0.034
 Identities = 46/194 (23%), Positives = 73/194 (37%), Gaps = 28/194 (14%)

Query: 244 FHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIG 303
           F C  +  P P+++WL +D       +R   +R      + SL++  V P + G Y C+ 
Sbjct: 170 FRCPAAGNPTPTIRWL-KDGQAFHGENRIGGIRLR--HQHWSLVMESVVPSDRGTYTCLV 226

Query: 304 QGQRGPPI------ILEATLHLAEIE-DMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWW 356
           +   G         +LE + H   ++  +P     V   GS+  + C           W 
Sbjct: 227 ENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV--VGSDVELLCKVYSDAQPHIQWL 284

Query: 357 EHAGVR--------------LPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQ 402
           +H  +               L T      +   L L N++  DAG YTC A N  G   Q
Sbjct: 285 KHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQ 344

Query: 403 DVNITVATV--PSW 414
              +TV     P+W
Sbjct: 345 SAWLTVLPEEDPTW 358


>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
            [Homo sapiens]
          Length = 796

 Score =  222 bits (565), Expect = 2e-57
 Identities = 162/542 (29%), Positives = 252/542 (46%), Gaps = 44/542 (8%)

Query: 555  LHFARVTRD-DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC 613
            L  A VT D +  N TC A N          +++V V ++F    +  T  + H   +  
Sbjct: 249  LTLANVTSDLNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPF 303

Query: 614  EAQGDPKPLIQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIA 666
               G P P ++W     +L+ T       L P  +   ++G L ++     ++G YT +A
Sbjct: 304  SVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLA 363

Query: 667  GNSCNIKHTEAPLYVVDKPVPEESEGP--------------GSPPPYKMIQTIGLSVGAA 712
             N             +D P     E P              G P   K     G+SV   
Sbjct: 364  ANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVG 423

Query: 713  VA-----YIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEV 767
            +A     ++  +L ++  C +R K      +P    PE              S+    E 
Sbjct: 424  LAVFACLFLSTLLLVLNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEG 481

Query: 768  ALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLV 827
              + L        +  S +   H  R  +     LG+  FG+VFLA+   L     + LV
Sbjct: 482  KGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLV 541

Query: 828  LVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFL 887
             VK+L+   E  + DF+RE E+   L H ++VR  G+C E  P  MV EY+  GDL +FL
Sbjct: 542  AVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL 601

Query: 888  RISKSKDEKLKS-------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSA 940
            R S   D KL +        PL   Q +A+ +QVA GM +L+   FVH+DLA RNCLV  
Sbjct: 602  R-SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ 660

Query: 941  QRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEV 999
               VK+   G+S+D+Y+++YY    +  +P+RWM PE+IL   F+T+SDVW+FGV++WE+
Sbjct: 661  GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI 720

Query: 1000 FTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIAS 1059
            FT+G+ P    ++ E +  +  G+  L +P  CP ++Y +M+ CW   P+ R S  ++ +
Sbjct: 721  FTYGKQPWYQLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA 779

Query: 1060 AL 1061
             L
Sbjct: 780  RL 781



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)

Query: 46  GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
           G   LLRC+VE  G     W+L       T  +     SL     +   D       C A
Sbjct: 208 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 267

Query: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
            +DV   E +   N SF              PAS   +Q  T V +        +DG P 
Sbjct: 268 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 310

Query: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
           P+ +W  +G+ L++     T       +   R+  LR   P H  +G Y+  A + FGQA
Sbjct: 311 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 370

Query: 210 CSS 212
            +S
Sbjct: 371 SAS 373



 Score = 30.8 bits (68), Expect = 7.1
 Identities = 36/162 (22%), Positives = 61/162 (37%), Gaps = 23/162 (14%)

Query: 376 LVLANI-AESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL 434
           L LAN+ ++ +    TC A N  G+    V + V+        P   QL      +  C+
Sbjct: 249 LTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-------PASVQLHTAVEMHHWCI 301

Query: 435 ---TQATPKPTVVWYRNQMLISEDSRF----------EVFKNGTLRINSVEVYDGTWYRC 481
                  P P++ W  N  +++E S            E  ++G LR+N     +   Y  
Sbjct: 302 PFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTL 361

Query: 482 MSSTPAGSIEAQARVQVLEK-LKFTP-PPQPQQCMEFDKEAT 521
           +++ P G   A      ++   +F P  P P      D  +T
Sbjct: 362 LAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNST 403


>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform a
            precursor [Homo sapiens]
          Length = 839

 Score =  221 bits (564), Expect = 2e-57
 Identities = 176/616 (28%), Positives = 279/616 (45%), Gaps = 81/616 (13%)

Query: 520  ATVPCSATGREKPTIKWERADGSSLP------EWVTDNAGTLHFARVTRDDAG-NYTCIA 572
            A + C+ +G   P + W      S+        W   +A  L    VT +D G   TCIA
Sbjct: 227  AVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIA 286

Query: 573  SNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC---EAQGDPKPLIQWKGKD 629
             N   G   A V LTV         P   ++ +    L  C     +G+P P + W    
Sbjct: 287  EN-VVGMSNASVALTVYY------PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNG 339

Query: 630  RILDPTKLGPRMHI-------FQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVV 682
            + L  +K+   +H+          G L+ +     ++G YT IA N     +     + +
Sbjct: 340  QPLRESKI---IHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFL 396

Query: 683  DKPVPEESEG-----PGSPPPYKMI------QTIGLSVG---AAVAYIIAVLGLMFYCKK 728
             +P PE ++        SP P   +       T G+S+    AA A ++ V+  +   K 
Sbjct: 397  KEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKY 456

Query: 729  RCKAKRLQKQP----EGEEPEMECLNGGPLQNGQPSA-EIQEEVALTSLGSGPAATNKRH 783
              ++K   K P     GEE     L+        PS+ +   +  +  +   P   N ++
Sbjct: 457  GRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQY 516

Query: 784  -STSDKMHFPRSSLQPITT--------LGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQS 834
                   H P + +Q I          LG+  FG+VFLA+   L     + LV VK+L+ 
Sbjct: 517  FRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKD 576

Query: 835  KDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLR------ 888
                 + DF+RE E+   L H ++V+  G+C + +P  MV EY+  GDL +FLR      
Sbjct: 577  PTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDA 636

Query: 889  -ISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVS 947
             I      +     L   Q + + +Q+A GM +L++  FVH+DLA RNCLV A   VK+ 
Sbjct: 637  MILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIG 696

Query: 948  ALGLSKDVYNSEYYHF---------------RQAWVPLRWMSPEAILEGDFSTKSDVWAF 992
              G+S+DVY+++YY                     +P+RWM PE+I+   F+T+SDVW+F
Sbjct: 697  DFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSF 756

Query: 993  GVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRP 1052
            GV++WE+FT+G+ P    ++ EV+  +  G+  L +P  CP ++Y +M  CW   P+ R 
Sbjct: 757  GVILWEIFTYGKQPWFQLSNTEVIECITQGRV-LERPRVCPKEVYDVMLGCWQREPQQRL 815

Query: 1053 SFSE---IASALGDST 1065
            +  E   I  ALG +T
Sbjct: 816  NIKEIYKILHALGKAT 831



 Score = 38.1 bits (87), Expect = 0.045
 Identities = 44/170 (25%), Positives = 62/170 (36%), Gaps = 23/170 (13%)

Query: 336 GSEERVTCLPPKGLPEPSVWWEHAGVR-LPTH--GRVYQKGH--ELVLANIAESDAG-VY 389
           G    +TC    G P P V W   G++ + TH     +   H   L L N+   D G   
Sbjct: 224 GDNAVITC-NGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282

Query: 390 TCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL---TQATPKPTVVWY 446
           TC A N+ G     V +TV         P+   LEE +     C+    +  P PT+ W 
Sbjct: 283 TCIAENVVGMSNASVALTV------YYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWL 336

Query: 447 RNQMLISEDSRFEV-------FKNGTLRINSVEVYDGTWYRCMSSTPAGS 489
            N   + E     V          G L  N    Y+   Y  ++  P G+
Sbjct: 337 HNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGT 386



 Score = 34.3 bits (77), Expect = 0.65
 Identities = 39/150 (26%), Positives = 57/150 (38%), Gaps = 22/150 (14%)

Query: 567 NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW- 625
           N  CI ++G Q  +   + ++        V     TV +G  A++ C   G P P + W 
Sbjct: 186 NLYCINADGSQLPL-FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWI 244

Query: 626 -KGKDRI-LDPTKLG-PRMHIFQNGSLVIHDVAPEDSG-RYTCIAGNSCNIKHTEAPLYV 681
             G   I    T L    +H     +L + +V  ED+G   TCIA N   + +    L V
Sbjct: 245 VTGLQSINTHQTNLNWTNVHAI---NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV 301

Query: 682 VDKPVPEESEGP-------------GSPPP 698
              P     E P             G+PPP
Sbjct: 302 YYPPRVVSLEEPELRLEHCIEFVVRGNPPP 331



 Score = 33.9 bits (76), Expect = 0.84
 Identities = 44/203 (21%), Positives = 72/203 (35%), Gaps = 22/203 (10%)

Query: 215 FTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPH 274
           F ++I+      + ++  ++ V   + A+  C  S  P P + W+      I   +   +
Sbjct: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSI--NTHQTN 257

Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334
           L    V A    L+      N     CI +   G        +  A +     + PRV +
Sbjct: 258 LNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG--------MSNASVALTVYYPPRVVS 309

Query: 335 AGSEE--RVTCLP--PKGLPEPSVWWEHAGVRLP----THGRVYQKGHE----LVLANIA 382
               E     C+    +G P P++ W H G  L      H   YQ+G      L+     
Sbjct: 310 LEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPT 369

Query: 383 ESDAGVYTCHAANLAGQRRQDVN 405
             + G YT  A N  G   Q +N
Sbjct: 370 HYNNGNYTLIAKNPLGTANQTIN 392



 Score = 31.6 bits (70), Expect = 4.2
 Identities = 41/180 (22%), Positives = 75/180 (41%), Gaps = 20/180 (11%)

Query: 45  QGRRALLRCEVEAPGPVHVYWLLDGAP---VQDTERRFAQGSSLSFAAVD-RLQDSG-TF 99
           +G  A++ C         V W++ G        T   +    +++   V+   +D+G T 
Sbjct: 223 EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282

Query: 100 QCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPT 159
            C+A ++V G     +NAS  +  +   P V+     E  ++   +  +R    G+P PT
Sbjct: 283 TCIA-ENVVG----MSNASVALT-VYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPT 332

Query: 160 YQWFRDGTPLSDGQSNHTVSSKERNLT---LRPAGPEH--SGLYSCCAHSAFGQACSSQN 214
             W  +G PL + +  H    +E  ++   L    P H  +G Y+  A +  G A  + N
Sbjct: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392


>gi|222144233 fibroblast growth factor receptor 2 isoform 4 precursor
            [Homo sapiens]
          Length = 709

 Score =  221 bits (562), Expect = 4e-57
 Identities = 144/500 (28%), Positives = 243/500 (48%), Gaps = 44/500 (8%)

Query: 593  TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 651
            T K+E     V   +T   +C A G+P P ++W K         ++G      Q+ SL++
Sbjct: 159  TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 218

Query: 652  HDVAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVG 710
              V P D G YTC+  N   +I HT    Y +D   P   +   + P Y  I    + V 
Sbjct: 219  ESVVPSDKGNYTCVVENEYGSINHT----YHLDVVAPGREKEITASPDYLEIAIYCIGVF 274

Query: 711  AAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQPSAEIQEEVAL 769
                 ++ V+         C+ K   K+P+   +P +  L        Q +   +   ++
Sbjct: 275  LIACMVVTVI--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM 326

Query: 770  TSLGSGPAATNKRHSTSD----------------KMHFPRSSLQPITTLGKSEFGEVFLA 813
             S       T +  ST+D                K  FPR  L     LG+  FG+V +A
Sbjct: 327  NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMA 386

Query: 814  KAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAE 869
            +A G+++   +  V V     KD+  + D      E+EM   +  H N++ LLG C +  
Sbjct: 387  EAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG 446

Query: 870  PHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEHLS 922
            P Y+++EY   G+L+++LR  +           ++  + ++ K  V+   Q+A GME+L+
Sbjct: 447  PLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA 506

Query: 923  NNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEG 981
            + + +H+DLAARN LV+    +K++  GL++D+ N +YY       +P++WM+PEA+ + 
Sbjct: 507  SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDR 566

Query: 982  DFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQ 1041
             ++ +SDVW+FGVLMWE+FT G  P+ G   +E+   L+ G  R+ +P  C ++LY +M+
Sbjct: 567  VYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMMMR 625

Query: 1042 RCWALSPKDRPSFSEIASAL 1061
             CW   P  RP+F ++   L
Sbjct: 626  DCWHAVPSQRPTFKQLVEDL 645



 Score = 38.5 bits (88), Expect = 0.034
 Identities = 43/202 (21%), Positives = 66/202 (32%), Gaps = 36/202 (17%)

Query: 35  IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
           I QP    A  G    +RC ++    +   W  DG  +    R    G  L        +
Sbjct: 44  ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100

Query: 95  DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
           DSG + C A                         DD  G E   +  S N +   W    
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160

Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
            +  +  A  A       V  RC   G+P PT +W ++G           + V ++  +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216

Query: 186 TLRPAGPEHSGLYSCCAHSAFG 207
            +    P   G Y+C   + +G
Sbjct: 217 IMESVVPSDKGNYTCVVENEYG 238



 Score = 34.7 bits (78), Expect = 0.49
 Identities = 58/251 (23%), Positives = 91/251 (36%), Gaps = 67/251 (26%)

Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
           K+  S+ E+    P   + +RC +         W +DG  L  G +N TV   E  L ++
Sbjct: 41  KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95

Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
            A P  SGLY+C A         +  F +++ D              E F    +    A
Sbjct: 96  GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153

Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
           P      + E+ +          F C     P P+++WL     F+ E  I   + R  H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213

Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334
                     SL++  V P + G Y C+ + + G    +  T HL            V  
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHL-----------DVVA 250

Query: 335 AGSEERVTCLP 345
            G E+ +T  P
Sbjct: 251 PGREKEITASP 261


>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
          Length = 869

 Score =  217 bits (553), Expect = 4e-56
 Identities = 132/398 (33%), Positives = 214/398 (53%), Gaps = 40/398 (10%)

Query: 682  VDKP-VPEESEGPGS-PPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQP 739
            VD P +P  S    S  P Y M  T+ +S+ ++ A  + +     YC   C+ ++  K  
Sbjct: 473  VDIPNLPSSSSSSFSVSPTYSM--TVIISIMSSFAIFVLLTITTLYC---CRRRKQWKNK 527

Query: 740  EGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKM---HFPRSSL 796
            + E   +                +  E+ L  L   P         + K+    +PR+++
Sbjct: 528  KRESAAVTLTT------------LPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNI 575

Query: 797  QPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSK-DEQQQLDFRRELEMFGKLNH 855
            + +  +G+  FG VF A+A GL      T+V VK L+ +     Q DF+RE  +  + ++
Sbjct: 576  EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDN 635

Query: 856  ANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKS--------KDEKLKSQ------- 900
             N+V+LLG+C   +P  ++ EY+  GDL +FLR             D  +++Q       
Sbjct: 636  PNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPP 695

Query: 901  PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 960
            PLS  +++ +  QVA GM +LS  +FVH+DLA RNCLV     VK++  GLS+++Y+++Y
Sbjct: 696  PLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADY 755

Query: 961  YHFRQ-AWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADL 1019
            Y   +   +P+RWM PE+I    ++T+SDVWA+GV++WE+F++G  P+ G A +EV+  +
Sbjct: 756  YKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYV 815

Query: 1020 QAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEI 1057
            + G   L  PE CP +LY LM+ CW+  P DRPSF+ I
Sbjct: 816  RDGNI-LSCPENCPVELYNLMRLCWSKLPADRPSFTSI 852



 Score =  100 bits (250), Expect = 6e-21
 Identities = 84/265 (31%), Positives = 118/265 (44%), Gaps = 38/265 (14%)

Query: 433 CLTQATPKPTVVWYRNQMLISE-DSRFEVFKNGTL-RINSVEVYDGTWYRCMSSTPAG-S 489
           C  ++ P+P + W RN++LI   D+R+ + +NG L  I SVE  D   Y C ++   G +
Sbjct: 49  CAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGA 108

Query: 490 IEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPE--- 546
           +E+   +QV  K K T PP   + +E  K A +PC+  G  KP++ W + D S L E   
Sbjct: 109 VESCGALQVKMKPKITRPPINVKIIEGLK-AVLPCTTMGNPKPSVSWIKGD-SPLRENSR 166

Query: 547 WVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQG 606
                +G+L    V ++DAG Y C+A N         V+L V VF      PE   V  G
Sbjct: 167 IAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFG 226

Query: 607 HTALLQCEAQGDPKPLIQW--------------KGKDRILDPTKLGPRMHIFQNGSLVIH 652
               L C A G P P I W                KDR++D      R+ +F        
Sbjct: 227 SFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVID-----SRLQLFIT------ 275

Query: 653 DVAPEDSGRYTCIAGNSCNIKHTEA 677
                  G YTCIA N    K + A
Sbjct: 276 -----KPGLYTCIATNKHGEKFSTA 295



 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 65/236 (27%), Positives = 107/236 (45%), Gaps = 15/236 (6%)

Query: 350 PEPSVWWEHAGVRLP---THGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVN- 405
           P+P + W    + +    T   + + G  L + ++ +SD G+Y C A N  G   +    
Sbjct: 55  PQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGA 114

Query: 406 ITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGT 465
           + V   P   + P + ++ EG    L C T   PKP+V W +    + E+SR  V ++G+
Sbjct: 115 LQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGS 174

Query: 466 LRINSVEVYDGTWYRCMSSTPAGSIEAQA---RVQVLEKLKFTPPPQPQQCMEFDKEATV 522
           LRI++V+  D   YRC++    G+  ++     V+V  ++   P       + F    T+
Sbjct: 175 LRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAP---ESHNVTFGSFVTL 231

Query: 523 PCSATGREKPTIKW----ERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASN 574
            C+ATG   PTI W          S+ E V D        ++     G YTCIA+N
Sbjct: 232 HCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRL-QLFITKPGLYTCIATN 286



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 65/300 (21%), Positives = 125/300 (41%), Gaps = 21/300 (7%)

Query: 130 VLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRP 189
           V+  P    +   +   T  C ++ +P+P   W R+   +    + +++    + LT+  
Sbjct: 29  VITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILS 88

Query: 190 AGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFS 249
                 G+Y C A++  G A  S     ++  +   ++   P +V +    +A+  C   
Sbjct: 89  VEDSDDGIYCCTANNGVGGAVESCG---ALQVKMKPKITRPPINVKIIEGLKAVLPCTTM 145

Query: 250 AQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGP 309
             P PS+ W+ + ++P+   S      R  V  +GSL +  V+  +AG YRC+ +   G 
Sbjct: 146 GNPKPSVSWI-KGDSPLRENS------RIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGT 198

Query: 310 PIILEATLHL---AEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTH 366
                  L +   A I   P  E    T GS   + C    G+P P++ W   G    + 
Sbjct: 199 AYSKVVKLEVEVFARILRAP--ESHNVTFGSFVTLHC-TATGIPVPTITWIENG-NAVSS 254

Query: 367 GRVYQKGHELVLANIAE---SDAGVYTCHAANLAGQRRQDVNITVA-TVPSWLKKPQDSQ 422
           G + +   + V+ +  +   +  G+YTC A N  G++          ++  W K  +D++
Sbjct: 255 GSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKDNK 314



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 49/193 (25%), Positives = 87/193 (45%), Gaps = 15/193 (7%)

Query: 36  KQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTER-RFAQGSSLSFAAVDRLQ 94
           + P +   ++G +A+L C         V W+   +P+++  R    +  SL    V + +
Sbjct: 125 RPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQK-E 183

Query: 95  DSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDG 154
           D+G ++CVA++ +    ++          +E    +L+ P S   +   + VTL C   G
Sbjct: 184 DAGQYRCVAKNSLGTAYSKVVKLE-----VEVFARILRAPESH-NVTFGSFVTLHCTATG 237

Query: 155 HPRPTYQWFRDGTPLSDGQSNHTVSSK--ERNLTLRPAGPEHSGLYSCCAHSAFGQACSS 212
            P PT  W  +G  +S G    +V  +  +  L L    P   GLY+C A +  G+  S+
Sbjct: 238 IPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKP---GLYTCIATNKHGEKFST 294

Query: 213 QN--FTLSIADES 223
                T+SIA+ S
Sbjct: 295 AKAAATISIAEWS 307


>gi|222144244 fibroblast growth factor receptor 2 isoform 9 precursor
            [Homo sapiens]
          Length = 680

 Score =  213 bits (541), Expect = 1e-54
 Identities = 163/592 (27%), Positives = 267/592 (45%), Gaps = 66/592 (11%)

Query: 524  CSATGREKPTIKWERADGSSLPEW------VTDNAGTLHFARVTRDDAGNYTCIASNGPQ 577
            C A G   PT++W +       E       V +   +L    V   D GNYTC+  N   
Sbjct: 90   CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN-EY 148

Query: 578  GQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRI 631
            G I     L V         +   +    +TV  G    + C+   D +P IQW  K   
Sbjct: 149  GSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-CKVYSDAQPHIQWI-KHVE 206

Query: 632  LDPTKLGPR--------MHIFQNGS----LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPL 679
             + +K GP          H   N S    L + +V   D+G Y C   N     +  A L
Sbjct: 207  KNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWL 266

Query: 680  YVVDKP-VPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQ 738
             V+ K   P   +   + P Y  I    + V      ++ V+         C+ K   K+
Sbjct: 267  TVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVI--------LCRMKNTTKK 318

Query: 739  PE-GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD---------- 787
            P+   +P +  L        Q +   +   ++ S       T +  ST+D          
Sbjct: 319  PDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEY 378

Query: 788  ------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQL 841
                  K  FPR  L     LG+  FG+V +A+A G+++   +  V V     KD+  + 
Sbjct: 379  ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 438

Query: 842  DFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD--- 894
            D      E+EM   +  H N++ LLG C +  P Y+++EY   G+L+++LR  +      
Sbjct: 439  DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY 498

Query: 895  ----EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALG 950
                 ++  + ++ K  V+   Q+A GME+L++ + +H+DLAARN LV+    +K++  G
Sbjct: 499  SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 558

Query: 951  LSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGG 1009
            L++D+ N +YY       +P++WM+PEA+ +  ++ +SDVW+FGVLMWE+FT G  P+ G
Sbjct: 559  LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 618

Query: 1010 QADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
               +E+   L+ G  R+ +P  C ++LY +M+ CW   P  RP+F ++   L
Sbjct: 619  IPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 669



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 2/85 (2%)

Query: 593 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 651
           T K+E     V   +T   +C A G+P P ++W K         ++G      Q+ SL++
Sbjct: 70  TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 129

Query: 652 HDVAPEDSGRYTCIAGNSC-NIKHT 675
             V P D G YTC+  N   +I HT
Sbjct: 130 ESVVPSDKGNYTCVVENEYGSINHT 154



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 48/193 (24%), Positives = 68/193 (35%), Gaps = 40/193 (20%)

Query: 244 FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPHLRRATVFANGSLLLTQVRPRNAG 297
           F C     P P+++WL     F+ E  I   + R  H          SL++  V P + G
Sbjct: 88  FRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHW---------SLIMESVVPSDKG 138

Query: 298 IYRCIGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGL 349
            Y C+ + + G    +  T HL  +E  P        L        G +    C      
Sbjct: 139 NYTCVVENEYGS---INHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDA 195

Query: 350 PEPSVWWEHA---GVRLPTHGRVYQK-----------GHELVLANIAESDAGVYTCHAAN 395
                W +H    G +    G  Y K              L L N+ E+DAG Y C  +N
Sbjct: 196 QPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSN 255

Query: 396 LAGQRRQDVNITV 408
             GQ  Q   +TV
Sbjct: 256 YIGQANQSAWLTV 268



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 7/119 (5%)

Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
           V  RC   G+P PT +W ++G           + V ++  +L +    P   G Y+C   
Sbjct: 86  VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 145

Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
           + +G    +  + L + + S  R +L    P +       +  F C+  +   P +QW+
Sbjct: 146 NEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 202



 Score = 39.3 bits (90), Expect = 0.020
 Identities = 46/182 (25%), Positives = 65/182 (35%), Gaps = 29/182 (15%)

Query: 433 CLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAG 488
           C     P PT+ W +N     ++ R   +K    + +L + SV   D   Y C+     G
Sbjct: 90  CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYG 149

Query: 489 SIEAQARVQVLEKLKFTP------PPQPQQCMEFDKEATVPCSATGREKPTIKW----ER 538
           SI     + V+E+    P      P      +  D E    C      +P I+W    E+
Sbjct: 150 SINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV--CKVYSDAQPHIQWIKHVEK 207

Query: 539 ADGSSLPEWV------------TDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQL 586
                 P+ +            + NA  L    VT  DAG Y C  SN   GQ      L
Sbjct: 208 NGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSN-YIGQANQSAWL 266

Query: 587 TV 588
           TV
Sbjct: 267 TV 268


>gi|222144231 fibroblast growth factor receptor 2 isoform 3 precursor
            [Homo sapiens]
          Length = 769

 Score =  213 bits (541), Expect = 1e-54
 Identities = 163/592 (27%), Positives = 267/592 (45%), Gaps = 66/592 (11%)

Query: 524  CSATGREKPTIKWERADGSSLPEW------VTDNAGTLHFARVTRDDAGNYTCIASNGPQ 577
            C A G   PT++W +       E       V +   +L    V   D GNYTC+  N   
Sbjct: 179  CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN-EY 237

Query: 578  GQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRI 631
            G I     L V         +   +    +TV  G    + C+   D +P IQW  K   
Sbjct: 238  GSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-CKVYSDAQPHIQWI-KHVE 295

Query: 632  LDPTKLGPR--------MHIFQNGS----LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPL 679
             + +K GP          H   N S    L + +V   D+G Y C   N     +  A L
Sbjct: 296  KNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWL 355

Query: 680  YVVDKP-VPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQ 738
             V+ K   P   +   + P Y  I    + V      ++ V+         C+ K   K+
Sbjct: 356  TVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVI--------LCRMKNTTKK 407

Query: 739  PE-GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD---------- 787
            P+   +P +  L        Q +   +   ++ S       T +  ST+D          
Sbjct: 408  PDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEY 467

Query: 788  ------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQL 841
                  K  FPR  L     LG+  FG+V +A+A G+++   +  V V     KD+  + 
Sbjct: 468  ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 527

Query: 842  DFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD--- 894
            D      E+EM   +  H N++ LLG C +  P Y+++EY   G+L+++LR  +      
Sbjct: 528  DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY 587

Query: 895  ----EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALG 950
                 ++  + ++ K  V+   Q+A GME+L++ + +H+DLAARN LV+    +K++  G
Sbjct: 588  SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 647

Query: 951  LSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGG 1009
            L++D+ N +YY       +P++WM+PEA+ +  ++ +SDVW+FGVLMWE+FT G  P+ G
Sbjct: 648  LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 707

Query: 1010 QADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
               +E+   L+ G  R+ +P  C ++LY +M+ CW   P  RP+F ++   L
Sbjct: 708  IPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 758



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 80/337 (23%), Positives = 120/337 (35%), Gaps = 80/337 (23%)

Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
           K+  S+ E+    P   + +RC +         W +DG  L  G +N TV   E  L ++
Sbjct: 41  KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95

Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
            A P  SGLY+C A         +  F +++ D              E F    +    A
Sbjct: 96  GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153

Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
           P      + E+ +          F C     P P+++WL     F+ E  I   + R  H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213

Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP-------- 326
                     SL++  V P + G Y C+ + + G    +  T HL  +E  P        
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSPHRPILQAG 261

Query: 327 LFEPRVFTAGSEERVTCLPPKGLPEPSVWW----EHAGVRLPTHGRVYQK---------- 372
           L        G +    C       +P + W    E  G +    G  Y K          
Sbjct: 262 LPANASTVVGGDVEFVCKVYSD-AQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSS 320

Query: 373 -GHELVLANIAESDAGVYTCHAANLAGQRRQDVNITV 408
               L L N+ E+DAG Y C  +N  GQ  Q   +TV
Sbjct: 321 NAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTV 357



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)

Query: 35  IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
           I QP    A  G    +RC ++    +   W  DG  +    R    G  L        +
Sbjct: 44  ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100

Query: 95  DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
           DSG + C A                         DD  G E   +  S N +   W    
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160

Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
            +  +  A  A       V  RC   G+P PT +W ++G           + V ++  +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216

Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
            +    P   G Y+C   + +G    +  + L + + S  R +L    P +       + 
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274

Query: 243 MFHCQFSAQPPPSLQWL 259
            F C+  +   P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 2/85 (2%)

Query: 593 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 651
           T K+E     V   +T   +C A G+P P ++W K         ++G      Q+ SL++
Sbjct: 159 TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 218

Query: 652 HDVAPEDSGRYTCIAGNSC-NIKHT 675
             V P D G YTC+  N   +I HT
Sbjct: 219 ESVVPSDKGNYTCVVENEYGSINHT 243



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 74/319 (23%), Positives = 105/319 (32%), Gaps = 66/319 (20%)

Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
           +P V+ A  G    V CL    L + +V  W   GV L  + R    G  L +      D
Sbjct: 46  QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101

Query: 386 AGVYTCHAANLAGQRRQD--VNITVAT------------------------VPSWLKKPQ 419
           +G+Y C A+           VN+T A                          P W    +
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEK 161

Query: 420 DSQLEEGKPGY----LDCLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSV 471
             +     P        C     P PT+ W +N     ++ R   +K    + +L + SV
Sbjct: 162 MEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESV 221

Query: 472 EVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTP------PPQPQQCMEFDKEATVPCS 525
              D   Y C+     GSI     + V+E+    P      P      +  D E    C 
Sbjct: 222 VPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV--CK 279

Query: 526 ATGREKPTIKW----ERADGSSLPEWV------------TDNAGTLHFARVTRDDAGNYT 569
                +P I+W    E+      P+ +            + NA  L    VT  DAG Y 
Sbjct: 280 VYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYI 339

Query: 570 CIASNGPQGQIRAHVQLTV 588
           C  SN   GQ      LTV
Sbjct: 340 CKVSN-YIGQANQSAWLTV 357


>gi|221316638 fibroblast growth factor receptor 2 isoform 2 precursor
            [Homo sapiens]
          Length = 822

 Score =  213 bits (541), Expect = 1e-54
 Identities = 163/592 (27%), Positives = 267/592 (45%), Gaps = 66/592 (11%)

Query: 524  CSATGREKPTIKWERADGSSLPEW------VTDNAGTLHFARVTRDDAGNYTCIASNGPQ 577
            C A G   PT++W +       E       V +   +L    V   D GNYTC+  N   
Sbjct: 179  CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN-EY 237

Query: 578  GQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRI 631
            G I     L V         +   +    +TV  G    + C+   D +P IQW  K   
Sbjct: 238  GSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-CKVYSDAQPHIQWI-KHVE 295

Query: 632  LDPTKLGPR--------MHIFQNGS----LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPL 679
             + +K GP          H   N S    L + +V   D+G Y C   N     +  A L
Sbjct: 296  KNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWL 355

Query: 680  YVVDKP-VPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQ 738
             V+ K   P   +   + P Y  I    + V      ++ V+         C+ K   K+
Sbjct: 356  TVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVI--------LCRMKNTTKK 407

Query: 739  PE-GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD---------- 787
            P+   +P +  L        Q +   +   ++ S       T +  ST+D          
Sbjct: 408  PDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEY 467

Query: 788  ------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQL 841
                  K  FPR  L     LG+  FG+V +A+A G+++   +  V V     KD+  + 
Sbjct: 468  ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 527

Query: 842  DFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD--- 894
            D      E+EM   +  H N++ LLG C +  P Y+++EY   G+L+++LR  +      
Sbjct: 528  DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY 587

Query: 895  ----EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALG 950
                 ++  + ++ K  V+   Q+A GME+L++ + +H+DLAARN LV+    +K++  G
Sbjct: 588  SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 647

Query: 951  LSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGG 1009
            L++D+ N +YY       +P++WM+PEA+ +  ++ +SDVW+FGVLMWE+FT G  P+ G
Sbjct: 648  LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 707

Query: 1010 QADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
               +E+   L+ G  R+ +P  C ++LY +M+ CW   P  RP+F ++   L
Sbjct: 708  IPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 758



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 80/337 (23%), Positives = 120/337 (35%), Gaps = 80/337 (23%)

Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
           K+  S+ E+    P   + +RC +         W +DG  L  G +N TV   E  L ++
Sbjct: 41  KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95

Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
            A P  SGLY+C A         +  F +++ D              E F    +    A
Sbjct: 96  GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153

Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
           P      + E+ +          F C     P P+++WL     F+ E  I   + R  H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213

Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP-------- 326
                     SL++  V P + G Y C+ + + G    +  T HL  +E  P        
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSPHRPILQAG 261

Query: 327 LFEPRVFTAGSEERVTCLPPKGLPEPSVWW----EHAGVRLPTHGRVYQK---------- 372
           L        G +    C       +P + W    E  G +    G  Y K          
Sbjct: 262 LPANASTVVGGDVEFVCKVYSD-AQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSS 320

Query: 373 -GHELVLANIAESDAGVYTCHAANLAGQRRQDVNITV 408
               L L N+ E+DAG Y C  +N  GQ  Q   +TV
Sbjct: 321 NAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTV 357



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)

Query: 35  IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
           I QP    A  G    +RC ++    +   W  DG  +    R    G  L        +
Sbjct: 44  ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100

Query: 95  DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
           DSG + C A                         DD  G E   +  S N +   W    
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160

Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
            +  +  A  A       V  RC   G+P PT +W ++G           + V ++  +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216

Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
            +    P   G Y+C   + +G    +  + L + + S  R +L    P +       + 
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274

Query: 243 MFHCQFSAQPPPSLQWL 259
            F C+  +   P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 2/85 (2%)

Query: 593 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 651
           T K+E     V   +T   +C A G+P P ++W K         ++G      Q+ SL++
Sbjct: 159 TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 218

Query: 652 HDVAPEDSGRYTCIAGNSC-NIKHT 675
             V P D G YTC+  N   +I HT
Sbjct: 219 ESVVPSDKGNYTCVVENEYGSINHT 243



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 74/319 (23%), Positives = 105/319 (32%), Gaps = 66/319 (20%)

Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
           +P V+ A  G    V CL    L + +V  W   GV L  + R    G  L +      D
Sbjct: 46  QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101

Query: 386 AGVYTCHAANLAGQRRQD--VNITVAT------------------------VPSWLKKPQ 419
           +G+Y C A+           VN+T A                          P W    +
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEK 161

Query: 420 DSQLEEGKPGY----LDCLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSV 471
             +     P        C     P PT+ W +N     ++ R   +K    + +L + SV
Sbjct: 162 MEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESV 221

Query: 472 EVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTP------PPQPQQCMEFDKEATVPCS 525
              D   Y C+     GSI     + V+E+    P      P      +  D E    C 
Sbjct: 222 VPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV--CK 279

Query: 526 ATGREKPTIKW----ERADGSSLPEWV------------TDNAGTLHFARVTRDDAGNYT 569
                +P I+W    E+      P+ +            + NA  L    VT  DAG Y 
Sbjct: 280 VYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYI 339

Query: 570 CIASNGPQGQIRAHVQLTV 588
           C  SN   GQ      LTV
Sbjct: 340 CKVSN-YIGQANQSAWLTV 357


>gi|222144239 fibroblast growth factor receptor 2 isoform 7 precursor
            [Homo sapiens]
          Length = 705

 Score =  212 bits (540), Expect = 1e-54
 Identities = 148/502 (29%), Positives = 247/502 (49%), Gaps = 52/502 (10%)

Query: 593  TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 651
            T K+E     V   +T   +C A G+P P ++W K         ++G      Q+ SL++
Sbjct: 159  TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 218

Query: 652  HDVAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVG 710
              V P D G YTC+  N   +I HT    Y +D  V E S       P++ I   GL   
Sbjct: 219  ESVVPSDKGNYTCVVENEYGSINHT----YHLD--VVERS-------PHRPILQAGLPAN 265

Query: 711  AAVAYIIAVLG--LMFYCKKRCKA-------KRLQKQPEGEEPE---------MECLNGG 752
            A+      V+G  + F CK    A       K ++K      P+         +   +  
Sbjct: 266  AST-----VVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKVSAESSS 320

Query: 753  PLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD-KMHFPRSSLQPITTLGKSEFGEVF 811
             + +  P   I   ++ T+     A  ++     D K  FPR  L     LG+  FG+V 
Sbjct: 321  SMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVV 380

Query: 812  LAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCRE 867
            +A+A G+++   +  V V     KD+  + D      E+EM   +  H N++ LLG C +
Sbjct: 381  MAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ 440

Query: 868  AEPHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEH 920
              P Y+++EY   G+L+++LR  +           ++  + ++ K  V+   Q+A GME+
Sbjct: 441  DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEY 500

Query: 921  LSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAIL 979
            L++ + +H+DLAARN LV+    +K++  GL++D+ N +YY       +P++WM+PEA+ 
Sbjct: 501  LASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALF 560

Query: 980  EGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRL 1039
            +  ++ +SDVW+FGVLMWE+FT G  P+ G   +E+   L+ G  R+ +P  C ++LY +
Sbjct: 561  DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMM 619

Query: 1040 MQRCWALSPKDRPSFSEIASAL 1061
            M+ CW   P  RP+F ++   L
Sbjct: 620  MRDCWHAVPSQRPTFKQLVEDL 641



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)

Query: 35  IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
           I QP    A  G    +RC ++    +   W  DG  +    R    G  L        +
Sbjct: 44  ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100

Query: 95  DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
           DSG + C A                         DD  G E   +  S N +   W    
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160

Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
            +  +  A  A       V  RC   G+P PT +W ++G           + V ++  +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216

Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
            +    P   G Y+C   + +G    +  + L + + S  R +L    P +       + 
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274

Query: 243 MFHCQFSAQPPPSLQWL 259
            F C+  +   P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291



 Score = 38.1 bits (87), Expect = 0.045
 Identities = 64/302 (21%), Positives = 103/302 (34%), Gaps = 52/302 (17%)

Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
           +P V+ A  G    V CL    L + +V  W   GV L  + R    G  L +      D
Sbjct: 46  QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101

Query: 386 AGVYTCHAANLAGQRRQD--VNITVAT------------------------VPSWLKKPQ 419
           +G+Y C A+           VN+T A                          P W    +
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEK 161

Query: 420 DSQLEEGKPGY----LDCLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSV 471
             +     P        C     P PT+ W +N     ++ R   +K    + +L + SV
Sbjct: 162 MEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESV 221

Query: 472 EVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTP------PPQPQQCMEFDKEATVPCS 525
              D   Y C+     GSI     + V+E+    P      P      +  D E    C 
Sbjct: 222 VPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV--CK 279

Query: 526 ATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQ 585
                +P I+W +    +  ++  D    L + +V +  A + + + SN P  +I   + 
Sbjct: 280 VYSDAQPHIQWIKHVEKNGSKYGPDG---LPYLKVLKVSAESSSSMNSNTPLVRITTRLS 336

Query: 586 LT 587
            T
Sbjct: 337 ST 338



 Score = 37.0 bits (84), Expect = 0.100
 Identities = 55/232 (23%), Positives = 87/232 (37%), Gaps = 56/232 (24%)

Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
           K+  S+ E+    P   + +RC +         W +DG  L  G +N TV   E  L ++
Sbjct: 41  KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95

Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
            A P  SGLY+C A         +  F +++ D              E F    +    A
Sbjct: 96  GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153

Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
           P      + E+ +          F C     P P+++WL     F+ E  I   + R  H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213

Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP 326
                     SL++  V P + G Y C+ + + G    +  T HL  +E  P
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSP 253



 Score = 34.3 bits (77), Expect = 0.65
 Identities = 30/114 (26%), Positives = 42/114 (36%), Gaps = 14/114 (12%)

Query: 524 CSATGREKPTIKWERADGSSLPEW------VTDNAGTLHFARVTRDDAGNYTCIASNGPQ 577
           C A G   PT++W +       E       V +   +L    V   D GNYTC+  N   
Sbjct: 179 CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN-EY 237

Query: 578 GQIRAHVQLTVA------VFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW 625
           G I     L V         +   +    +TV  G    + C+   D +P IQW
Sbjct: 238 GSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-CKVYSDAQPHIQW 290


>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
            [Homo sapiens]
          Length = 694

 Score =  211 bits (537), Expect = 3e-54
 Identities = 179/616 (29%), Positives = 274/616 (44%), Gaps = 80/616 (12%)

Query: 506  PPPQPQQCMEFDK----EATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVT 561
            P P  Q+ + F      E + P    G   PT+  +   G    E V      L     +
Sbjct: 41   PEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNAS 100

Query: 562  RDDAGNYTCIASNGPQGQIRAHVQLT-------------------VAVFITFKVEPERT- 601
             +D+G Y+C      +      V++T                   V     +   PER  
Sbjct: 101  HEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMD 160

Query: 602  ----TVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVIHDVAP 656
                 V   +T   +C A G+P P I W K         ++G      Q  SLV+  V P
Sbjct: 161  KKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVP 220

Query: 657  EDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAY 715
             D G YTC+  N   +I+ T    Y +D  V E S       P++ I   GL        
Sbjct: 221  SDRGNYTCVVENKFGSIRQT----YTLD--VLERS-------PHRPILQAGLPANQT--- 264

Query: 716  IIAVLG--LMFYCK------------KRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSA 761
              AVLG  + F+CK            K  +    +  P+G  P +  L      N   S+
Sbjct: 265  --AVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT-PYVTVLKVSLESNASMSS 321

Query: 762  EIQ-EEVALTSLGSGPAATNKRH---STSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQG 817
                  +A  S G GP   N          K    R+ L     LG+  FG+V +A+A G
Sbjct: 322  NTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIG 381

Query: 818  LEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYM 873
            +++  A   V V     KD+    D      E+EM   +  H N++ LLG C +  P Y+
Sbjct: 382  IDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYV 441

Query: 874  VLEYVDLGDLKQFLRISK------SKDE-KLKSQPLSTKQKVALCTQVALGMEHLSNNRF 926
            ++EY   G+L++FLR  +      S D  K   + L+ K  V+   QVA GME+L++ + 
Sbjct: 442  LVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKC 501

Query: 927  VHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAILEGDFST 985
            +H+DLAARN LV+    +K++  GL++DV+N +YY       +P++WM+PEA+ +  ++ 
Sbjct: 502  IHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTH 561

Query: 986  KSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWA 1045
            +SDVW+FGVL+WE+FT G  P+ G   +E+   L+ G  R+ +P  C   LY +M+ CW 
Sbjct: 562  QSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTHDLYMIMRECWH 620

Query: 1046 LSPKDRPSFSEIASAL 1061
             +P  RP+F ++   L
Sbjct: 621  AAPSQRPTFKQLVEDL 636



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 55/259 (21%), Positives = 90/259 (34%), Gaps = 48/259 (18%)

Query: 37  QPSSQDAL---QGRRALLRCEVEAPGPVH-VYWLLDGAPVQDTERRFAQGSSLSFAAVDR 92
           +P  Q+ L    G    L C     GP+    W+ DG  +  +ER       L       
Sbjct: 42  EPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASH 101

Query: 93  LQDSGTFQCVAR--------------------DDVTGEEARSANASFNIKWIEAGPVVLK 132
            +DSG + C  R                    DD  GE+            ++ G     
Sbjct: 102 -EDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTG------VDTGAPYWT 154

Query: 133 HPASEAE----IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS-----KER 183
            P    +    +     V  RC   G+P P+  W ++G    + +  H +       ++ 
Sbjct: 155 RPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNG---REFRGEHRIGGIKLRHQQW 211

Query: 184 NLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYE 240
           +L +    P   G Y+C   + FG     Q +TL + + S  R +L    P +       
Sbjct: 212 SLVMESVVPSDRGNYTCVVENKFGSI--RQTYTLDVLERSPHRPILQAGLPANQTAVLGS 269

Query: 241 EAMFHCQFSAQPPPSLQWL 259
           +  FHC+  +   P +QWL
Sbjct: 270 DVEFHCKVYSDAQPHIQWL 288



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 53/242 (21%), Positives = 81/242 (33%), Gaps = 35/242 (14%)

Query: 329 EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGV 388
           E  VF +G    ++C PP G P     W   G  L    RV      L + N +  D+G 
Sbjct: 47  EQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGA 106

Query: 389 YTCHAANLAGQRRQDVNITVATVPS------WLKKPQDSQLEEGKPGY------------ 430
           Y+C    L  +     ++ V   PS         + +D+ ++ G P +            
Sbjct: 107 YSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLA 165

Query: 431 --------LDCLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTW 478
                     C     P P++ W +N      + R    K      +L + SV   D   
Sbjct: 166 VPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGN 225

Query: 479 YRCMSSTPAGSIEAQARVQVLEKLKFTPPPQ----PQQCMEFDKEATVPCSATGREKPTI 534
           Y C+     GSI     + VLE+    P  Q      Q      +    C      +P I
Sbjct: 226 YTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHI 285

Query: 535 KW 536
           +W
Sbjct: 286 QW 287


>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
          Length = 1620

 Score =  210 bits (535), Expect = 5e-54
 Identities = 124/381 (32%), Positives = 207/381 (54%), Gaps = 25/381 (6%)

Query: 695  SPPPYKMIQTIGLSVGAAV--AYIIAVLGLMFYCKKRCKAKRLQK-QPEGEEPEMECLNG 751
            +P P+  +  I   V +A+  A ++A  G+M   ++  K + LQ  Q E + PE +    
Sbjct: 1026 TPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRR--KHQELQAMQMELQSPEYKL--- 1080

Query: 752  GPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVF 811
                     ++++    +T          K  S SD    PR ++  I  LG   FGEV+
Sbjct: 1081 ---------SKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVY 1131

Query: 812  LAKAQGLEEGVAETLVLVKSLQSK-DEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEP 870
              +  G+    +   V VK+L     EQ +LDF  E  +  K NH N+VR +G+  ++ P
Sbjct: 1132 EGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLP 1191

Query: 871  HYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKD 930
             +++LE +  GDLK FLR ++ +  +  S  L+    + +   +A G ++L  N F+H+D
Sbjct: 1192 RFILLELMAGGDLKSFLRETRPRPSQPSS--LAMLDLLHVARDIACGCQYLEENHFIHRD 1249

Query: 931  LAARNCLVSAQ---RQVKVSALGLSKDVYNSEYYHFRQ-AWVPLRWMSPEAILEGDFSTK 986
            +AARNCL++     R  K+   G+++D+Y + YY     A +P++WM PEA +EG F++K
Sbjct: 1250 IAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSK 1309

Query: 987  SDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWAL 1046
            +D W+FGVL+WE+F+ G MP+  +++ EVL  + +G  R+  P+ CP  +YR+M +CW  
Sbjct: 1310 TDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSG-GRMDPPKNCPGPVYRIMTQCWQH 1368

Query: 1047 SPKDRPSFSEIASALGDSTVD 1067
             P+DRP+F+ I   +   T D
Sbjct: 1369 QPEDRPNFAIILERIEYCTQD 1389


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,354,553
Number of Sequences: 37866
Number of extensions: 2414720
Number of successful extensions: 17499
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 618
Number of HSP's successfully gapped in prelim test: 526
Number of HSP's that attempted gapping in prelim test: 6265
Number of HSP's gapped (non-prelim): 5024
length of query: 1070
length of database: 18,247,518
effective HSP length: 113
effective length of query: 957
effective length of database: 13,968,660
effective search space: 13368007620
effective search space used: 13368007620
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.