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Search of human proteins with 157502225
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157502225 Janus kinase and microtubule interacting protein 3
[Homo sapiens]
(844 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157502225 Janus kinase and microtubule interacting protein 3 ... 1607 0.0
gi|150456473 janus kinase and microtubule interacting protein 1 ... 1004 0.0
gi|45237195 Janus kinase and microtubule interacting protein 2 [... 939 0.0
gi|21389505 janus kinase and microtubule interacting protein 1 i... 713 0.0
gi|148746195 trichohyalin [Homo sapiens] 121 2e-27
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 116 1e-25
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 115 2e-25
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 110 7e-24
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 108 3e-23
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 107 6e-23
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 107 6e-23
gi|156104908 myosin heavy chain 6 [Homo sapiens] 106 8e-23
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 105 1e-22
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 105 1e-22
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 105 1e-22
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 105 2e-22
gi|34577114 cytomatrix protein p110 [Homo sapiens] 104 4e-22
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 103 7e-22
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 103 7e-22
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 103 7e-22
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 103 7e-22
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 103 7e-22
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 103 7e-22
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 103 7e-22
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 103 7e-22
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 103 7e-22
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 103 7e-22
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 103 7e-22
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 103 7e-22
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 102 2e-21
>gi|157502225 Janus kinase and microtubule interacting protein 3
[Homo sapiens]
Length = 844
Score = 1607 bits (4160), Expect = 0.0
Identities = 844/844 (100%), Positives = 844/844 (100%)
Query: 1 MSKRGMSSRAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQV 60
MSKRGMSSRAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQV
Sbjct: 1 MSKRGMSSRAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQV 60
Query: 61 REHEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALL 120
REHEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALL
Sbjct: 61 REHEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALL 120
Query: 121 SALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADK 180
SALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADK
Sbjct: 121 SALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADK 180
Query: 181 IKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQ 240
IKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQ
Sbjct: 181 IKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQ 240
Query: 241 LQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIA 300
LQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIA
Sbjct: 241 LQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIA 300
Query: 301 ELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMEN 360
ELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMEN
Sbjct: 301 ELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMEN 360
Query: 361 KLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLET 420
KLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLET
Sbjct: 361 KLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLET 420
Query: 421 AGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQ 480
AGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQ
Sbjct: 421 AGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQ 480
Query: 481 TPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQ 540
TPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQ
Sbjct: 481 TPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQ 540
Query: 541 AEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQD 600
AEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQD
Sbjct: 541 AEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQD 600
Query: 601 ARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKL 660
ARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKL
Sbjct: 601 ARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKL 660
Query: 661 DILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKG 720
DILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKG
Sbjct: 661 DILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKG 720
Query: 721 YLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKR 780
YLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKR
Sbjct: 721 YLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKR 780
Query: 781 QVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEKFLFLFLFFSLAF 840
QVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEKFLFLFLFFSLAF
Sbjct: 781 QVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEKFLFLFLFFSLAF 840
Query: 841 ILWS 844
ILWS
Sbjct: 841 ILWS 844
>gi|150456473 janus kinase and microtubule interacting protein 1
isoform 1 [Homo sapiens]
Length = 831
Score = 1004 bits (2595), Expect = 0.0
Identities = 528/848 (62%), Positives = 667/848 (78%), Gaps = 23/848 (2%)
Query: 1 MSKRGMSSRAKGDKAEALA-ALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQ 59
MSK+G R+KG+K E A+Q ANE+LRAKLT IQIE QQEKSKV K+ RE+ QE +
Sbjct: 1 MSKKG---RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKL-RERLQEAKL 56
Query: 60 VREHEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQAL 119
RE EQ + ++ELK KLHEEK KELQA+RE L+RQHE E R KIK+ E QRLQA
Sbjct: 57 EREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
Query: 120 LSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQAD 179
L+ LRDG +KVKT LL+EA+EEA++ F+ E++++QQEI ELK A++Q EEAL+ +QAD
Sbjct: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
Query: 180 KIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRL 239
K KAA++R+ Y HQ+E+ RIK+ECER+IRRLM+EIK KDR + LE+ELGVQAG Q+L
Sbjct: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKL 236
Query: 240 QLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKI 299
LQKEALDEQL QV+EA+RH SP+RELP G GD + G +Q +DE+D RRFQLKI
Sbjct: 237 LLQKEALDEQLVQVKEAERHHSSPKRELP--PGIGDMVELMGVQDQHMDERDVRRFQLKI 294
Query: 300 AELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRME 359
AEL+++IRKLEDRN LL++ERNELLKR RE E Q KPL++KNKR+++KNEDL +++RME
Sbjct: 295 AELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRME 354
Query: 360 NKLKFVTQENIEMRQRAGI---IRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSK 416
K+K +T+EN+EM+++ ++R +SLNDL ++DE+E++FL+LQ++EQQ++ID+LS
Sbjct: 355 EKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLS- 413
Query: 417 TLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTD 476
LER++LLR ++ R K K PK VVETFFG+DEE+ S SY TD
Sbjct: 414 -----------LERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTD 462
Query: 477 RTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTR 536
RTD+TP TP++DL++ A+EE +LRF QLT EYQALQRAYALLQEQVGGTLDAERE +TR
Sbjct: 463 RTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTR 522
Query: 537 EQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRH 596
EQLQA++ R QA+IEDLEK L E+GQD KW+EEKQ L R NQ+L+EKI ++E EE +L++
Sbjct: 523 EQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKN 582
Query: 597 EVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDG-KSPLQVYCEAEGVTDIVVAE 655
E+QDA+DQNELLEFR+LELEERER+SPA + T F + S LQ++C EGV D+ V+E
Sbjct: 583 EMQDAKDQNELLEFRVLELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSE 642
Query: 656 LMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELF 715
LMKKLDILGDN NL NEEQV +IQA TVL L EKWL+QIE TEAAL +KM+DLE EK+LF
Sbjct: 643 LMKKLDILGDNGNLRNEEQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLF 702
Query: 716 SKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAV 775
S+QKGYL+EELDYRKQALDQA I +LEA LY ALQQE G + E LSE +RE L+ AV
Sbjct: 703 SRQKGYLEEELDYRKQALDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAV 762
Query: 776 EQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEKFLFLFLF 835
E+ +RQ++ + RE D+QILRERMELLQ AQQRI+ELE+++E QKR +KELEEKFLFLFLF
Sbjct: 763 EKVRRQILRQSREFDSQILRERMELLQQAQQRIRELEDKLEFQKRHLKELEEKFLFLFLF 822
Query: 836 FSLAFILW 843
FSLAFILW
Sbjct: 823 FSLAFILW 830
>gi|45237195 Janus kinase and microtubule interacting protein 2
[Homo sapiens]
Length = 810
Score = 939 bits (2426), Expect = 0.0
Identities = 505/832 (60%), Positives = 645/832 (77%), Gaps = 32/832 (3%)
Query: 1 MSKRGMSSRAKGDKAEAL-AALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQ 59
MSK+G R KG+K EAL ALQAANEDLR KLTDIQIEL QEKSKVSK+EREK QE ++
Sbjct: 1 MSKKG---RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKR 57
Query: 60 VREHEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQAL 119
+RE EQ K VL+TELK KLHEEKMKELQAVRE L++QHE E+ R +K++D E QRL++
Sbjct: 58 IRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSA 117
Query: 120 LSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQAD 179
L ALRDG +KV+T L EA+EEA+K F+ E++K+ QEI++LK AK+QV+EAL+ +IQAD
Sbjct: 118 LCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQAD 177
Query: 180 KIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRL 239
KIKA ++RS + HQE I++IK E ER+IRRLM+EIK KDR +F LE+EL Q G+ Q+L
Sbjct: 178 KIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKL 237
Query: 240 QLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKI 299
QLQKEALDEQL V+EA+ + SP+RE+P AGD S+H SP D RR Q +I
Sbjct: 238 QLQKEALDEQLFLVKEAECNMSSPKREIP--GRAGDGSEHCSSP-------DLRRNQKRI 288
Query: 300 AELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRME 359
AEL+A IRKLEDRN LL +ERNELLKRVRE E Q KPLL++NK L+++N++L +L+RME
Sbjct: 289 AELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRME 348
Query: 360 NKLKFVTQENIEMRQRAGI---IRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSK 416
KLK VT+EN EMR++ +++ SLNDLDQ+ +E+E +FLKLQ++EQQN+IDEL++
Sbjct: 349 EKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTR 408
Query: 417 TLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTD 476
+R+KL+R RK R+ + +PV+ + F GYDE+ S++S+ SS++ +
Sbjct: 409 ------------DREKLIRRRKHRRSSKPIKRPVL-DPFIGYDED-SMDSETSSMA--SF 452
Query: 477 RTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTR 536
RTD+TP TPDDDL+E +A EE+ELRFRQLT EYQALQRAYALLQEQ GG +DAERE K +
Sbjct: 453 RTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQ 512
Query: 537 EQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRH 596
EQLQAEV R +A+IEDLE LA++GQD W+E+KQ +RNQEL+EKI++ E E RL+
Sbjct: 513 EQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQ 572
Query: 597 EVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAEL 656
E+QDARDQNELLEFR LELEERER+SP + PF DG S LQ+YC EGV D+ + +L
Sbjct: 573 ELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDL 632
Query: 657 MKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFS 716
+K+LDILGDN NL NEEQV +IQA TVL+LAEKW+QQIE EAAL +KM++LES+ E F
Sbjct: 633 IKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFC 692
Query: 717 KQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVE 776
K KGYL+EELDYRKQALDQA I ELEA LY+ALQQE K ELLSE+++E+L+ AVE
Sbjct: 693 KIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVE 752
Query: 777 QWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEK 828
+ +RQ++ + RE D QIL+ERMELLQ A QRI++LE++ + QKRQIK+LEEK
Sbjct: 753 KLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEK 804
>gi|21389505 janus kinase and microtubule interacting protein 1
isoform 2 [Homo sapiens]
Length = 626
Score = 713 bits (1841), Expect = 0.0
Identities = 374/623 (60%), Positives = 485/623 (77%), Gaps = 22/623 (3%)
Query: 1 MSKRGMSSRAKGDKAEALA-ALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQ 59
MSK+G R+KG+K E A+Q ANE+LRAKLT IQIE QQEKSKV K+ RE+ QE +
Sbjct: 1 MSKKG---RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKL-RERLQEAKL 56
Query: 60 VREHEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQAL 119
RE EQ + ++ELK KLHEEK KELQA+RE L+RQHE E R KIK+ E QRLQA
Sbjct: 57 EREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
Query: 120 LSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQAD 179
L+ LRDG +KVKT LL+EA+EEA++ F+ E++++QQEI ELK A++Q EEAL+ +QAD
Sbjct: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
Query: 180 KIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRL 239
K KAA++R+ Y HQ+E+ RIK+ECER+IRRLM+EIK KDR + LE+ELGVQAG Q+L
Sbjct: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKL 236
Query: 240 QLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKI 299
LQKEALDEQL QV+EA+RH SP+RELP G GD + G +Q +DE+D RRFQLKI
Sbjct: 237 LLQKEALDEQLVQVKEAERHHSSPKRELP--PGIGDMVELMGVQDQHMDERDVRRFQLKI 294
Query: 300 AELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRME 359
AEL+++IRKLEDRN LL++ERNELLKR RE E Q KPL++KNKR+++KNEDL +++RME
Sbjct: 295 AELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRME 354
Query: 360 NKLKFVTQENIEMRQRAGI---IRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSK 416
K+K +T+EN+EM+++ ++R +SLNDL ++DE+E++FL+LQ++EQQ++ID+LS
Sbjct: 355 EKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLS- 413
Query: 417 TLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTD 476
LER++LLR ++ R K K PK VVETFFG+DEE+ S SY TD
Sbjct: 414 -----------LERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTD 462
Query: 477 RTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTR 536
RTD+TP TP++DL++ A+EE +LRF QLT EYQALQRAYALLQEQVGGTLDAERE +TR
Sbjct: 463 RTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTR 522
Query: 537 EQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRH 596
EQLQA++ R QA+IEDLEK L E+GQD KW+EEKQ L R NQ+L+EKI ++E EE +L++
Sbjct: 523 EQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKN 582
Query: 597 EVQDARDQNELLEFRILELEERE 619
E+QDA+DQNELLEFR+LELE R+
Sbjct: 583 EMQDAKDQNELLEFRVLELEVRD 605
Score = 42.7 bits (99), Expect = 0.001
Identities = 71/332 (21%), Positives = 134/332 (40%), Gaps = 51/332 (15%)
Query: 506 TMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMK 565
T E QAL+ EQ +A R K +E E+QR QA + L A++ +
Sbjct: 81 TKELQALREGLIRQHEQ-----EAARTAKIKE---GELQRLQATLNVLRDGAADKVKTAL 132
Query: 566 WIEEKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAI 625
E + EEAR + + R Q E+LE + + E S +
Sbjct: 133 LTEAR-------------------EEARRAFDGERLRLQQEILELKAARKQAEEALSNCM 173
Query: 626 SFHHTPFVDGKSPLQVY-CEAEGVTDIVVAELMKKLDIL--GDNANLTNEEQVVVIQART 682
T D ++ Q + E + ++ + +D + D L E+++ V +T
Sbjct: 174 QADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQT 233
Query: 683 VLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILE 742
L +K AL ++V ++ + S K L + + + ++H+ E
Sbjct: 234 QKLLLQK---------EALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDE 284
Query: 743 LEAMLYDALQQEAGAKVAE------LLSEEEREKLKVAVEQWKRQVMSELRERDAQILRE 796
+ + E + + + LL++E E LK + E + L E++ ++ ++
Sbjct: 285 RDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRE--TEVQLKPLVEKNKRMNKK 342
Query: 797 RMELLQLAQQRIKELEERIEAQKRQIKELEEK 828
+LL Q I+ +EE+I+ R+ E++EK
Sbjct: 343 NEDLL----QSIQRMEEKIKNLTRENVEMKEK 370
Score = 36.2 bits (82), Expect = 0.13
Identities = 39/165 (23%), Positives = 69/165 (41%), Gaps = 31/165 (18%)
Query: 695 EETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQE 754
EE A L ++ + EK K + L E R+Q + +I EL+A L++ +E
Sbjct: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
Query: 755 AGAKVAELLSEEEREKLKV---------------------AVEQWKRQVMSELRER---- 789
A L+ + E+E + A ++ K +++E RE
Sbjct: 84 LQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRA 143
Query: 790 -DAQILRERMELLQLAQQRIKELEERI----EAQKRQIKELEEKF 829
D + LR + E+L+L R K+ EE + +A K + +L +
Sbjct: 144 FDGERLRLQQEILELKAAR-KQAEEALSNCMQADKTKAADLRAAY 187
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 121 bits (304), Expect = 2e-27
Identities = 194/841 (23%), Positives = 362/841 (43%), Gaps = 113/841 (13%)
Query: 38 ELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLTELKT-----------KLHEEKMKE 86
E ++ + ++ + + E+ L++ E E+H+ +LK KL EE+ +E
Sbjct: 439 EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE 498
Query: 87 LQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSA---LRDGGPEKVKTVLLSEAKEEA 143
Q RE LR+ + E + E +RLQ L + LR E+ + +L E ++
Sbjct: 499 QQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRL 558
Query: 144 KKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKE 203
++ +++K +QE + KR+ E Q + E R L +EE+ R+++E
Sbjct: 559 EQERREQRLKREQEERRDQLLKREEERR-----QQRLKREQEERLEQRLKREEVERLEQE 613
Query: 204 CEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSP 263
ER +RL E ++R +L+ E + Q + Q+E +++L + E +R
Sbjct: 614 -ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRL 672
Query: 264 RRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERNEL 323
+RE EQ+L E++ + + +I S I + + ++++
Sbjct: 673 KRE-----------HEEERREQELAEEEQEQARERIK--SRIPKWQWQLESEADARQSKV 719
Query: 324 LKRVREAESQYKPLLDKNKRLSRKNE------DLSHALRRMENKLK-FVTQENIEMRQRA 376
R R+ E Q + + KR R++E + +H ++ E + + F Q E +
Sbjct: 720 YSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSER 779
Query: 377 GIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKLLRF 436
G R+ S + Q ER++ + Q EQ+ L +E K + ER+K L+F
Sbjct: 780 G--RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR----RQRREREKELQF 833
Query: 437 RKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKE 496
++ +++ + + ++ +EE L+ D Q R DQ LEE +
Sbjct: 834 LEEEEQLQRRERAQQLQ-----EEEDGLQEDQERRRSQEQRRDQKWRW---QLEEERKRR 885
Query: 497 ETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKA 556
L + E L++ LLQE+ ERE K R Q Q R + +++ E+
Sbjct: 886 RHTLYAKPALQEQ--LRKEQQLLQEEEEELQREERE-KRRRQEQERQYREEEQLQQEEEQ 942
Query: 557 LAEQGQDMKWIEEKQALYRRNQELVEKIKQM---ETEEARLRHEVQDARDQNELL-EFRI 612
L + ++ + +E++ YR++++L +K +Q+ E E+ R + + R++ EL E
Sbjct: 943 LLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQ 1002
Query: 613 LELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNE 672
L EERE++ E E + KK ++ + L E
Sbjct: 1003 LLREEREKRRRQ-------------------EWE-------RQYRKKDELQQEEEQLLRE 1036
Query: 673 EQVVV-IQARTVLTLAEKWLQQIEET---EAALQRKMVDLE----SEKELFSKQKGYLDE 724
E+ +Q R E+ LQQ EE E R+ +LE E+EL +++ L E
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE 1096
Query: 725 ELDYRK-----------QALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKV 773
E + R+ + L Q + +L E + E + E + +EE + L+
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE 1156
Query: 774 AVEQWKRQVMS-------ELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELE 826
E+ +RQ + EL++ + Q+LRE E + ++R EE ++ QKR+ + +
Sbjct: 1157 EPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRD 1216
Query: 827 E 827
E
Sbjct: 1217 E 1217
Score = 112 bits (281), Expect = 1e-24
Identities = 195/838 (23%), Positives = 353/838 (42%), Gaps = 122/838 (14%)
Query: 21 LQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLTE--LKTK 78
L+ E L+ + Q ELQ+E+ ++ K+ER QELR+ R+ E+ + L E L+ K
Sbjct: 253 LRKEEEKLQEEEPQRQRELQEEEEQLRKLER---QELRRERQEEEQQQQRLRREQQLRRK 309
Query: 79 LHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVKTVLLSE 138
EE+ ++ + RE R+ + E R +++ + +R + L R+ E+ + L E
Sbjct: 310 QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLR--REQEEERREQQLRRE 367
Query: 139 AKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEIT 198
+EE ++ ++++ +Q++ + +R+ + + ++R L +E+
Sbjct: 368 QEEERRE----QQLRREQQLRREQQLRREQQLR----------REQQLRREQQLRREQQL 413
Query: 199 RIKKECERE--IRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREA 256
R +++ RE +RR EE + + + Q QRL+ ++E + L + E
Sbjct: 414 RREQQLRREQQLRREQEEERHEQKHE---------QERREQRLKREQEERRDWLKREEET 464
Query: 257 DRHPGS------------PRRELPHAAGAGDASDHSGSPEQQL--DEKDARRFQLKIAE- 301
+RH RRE + + EQQL ++++ R +LK E
Sbjct: 465 ERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEE 524
Query: 302 ---LSAIIRKLEDRNALLSEERNELLKRVREA--ESQYKPLLDKNKRLSRKNEDLSHALR 356
L +R + E R +LLKR E E + + K ++ R+++ L
Sbjct: 525 EERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE 584
Query: 357 RMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSK 416
R + +LK +E +E R + + R Q+ER LK + E++ +L K
Sbjct: 585 RRQQRLKREQEERLEQRLKREEVER--------LEQEERREQRLKREEPEEERR-QQLLK 635
Query: 417 TLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTD 476
+ E + L R++ R R+QR K +EE LE ++ +
Sbjct: 636 SEEQEERRQQQLRREQQER-REQRLKRE--------------EEEERLEQRLKR-EHEEE 679
Query: 477 RTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQ-RAYALLQEQVGGTLDAEREVKT 535
R +Q + + K QL E A Q + Y+ ++Q G E+E K
Sbjct: 680 RREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKR 739
Query: 536 REQLQAEVQRAQARIEDLEKALAEQGQDMKW---IEEKQALYRRNQELVEKIKQMETEEA 592
R + ++E+Q + ++ EQ +D W EEK R Q L + E E
Sbjct: 740 RRR-ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE--RGRQRLSARPPLREQRER 796
Query: 593 RLRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIV 652
+LR E + R+Q L E E R+R+ F++ + LQ A+
Sbjct: 797 QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQ---FLEEEEQLQRRERAQ------ 847
Query: 653 VAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEK 712
+L ++ D L ++ ++ Q R +KW Q+EE +RK
Sbjct: 848 --QLQEEEDGLQEDQERRRSQE----QRRD-----QKWRWQLEE-----ERK----RRRH 887
Query: 713 ELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLK 772
L++K L E+L +Q L + + + E +QE + E L +EE + L+
Sbjct: 888 TLYAKPA--LQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLR 945
Query: 773 VAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEKFL 830
E+ +RQ ER+ Q +++ +L Q +Q + E E+ Q+R+ K EE+ L
Sbjct: 946 EEREKRRRQ------ERERQYRKDK-KLQQKEEQLLGEEPEKRRRQEREKKYREEEEL 996
Score = 106 bits (265), Expect = 8e-23
Identities = 196/878 (22%), Positives = 374/878 (42%), Gaps = 107/878 (12%)
Query: 36 QIELQQEKSKVSKVEREKNQELRQVREH--EQHKTAVLLTELKTKLHEEKMK-ELQAVRE 92
++E + ++ +V ++E+E+ +E R RE E+ + +L +E + + +++++ E Q RE
Sbjct: 597 RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE 656
Query: 93 TLLRQHEAE--LLRVIKIKDNENQRLQALLSALRDGGPEKVKT-------VLLSEA---- 139
L++ E E L + +K + E +R Q L ++ E++K+ L SEA
Sbjct: 657 QRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQ 716
Query: 140 --------KEEAKKGFEVEKVKMQQEISELKG-----AKRQVEEA-----LTLVIQADKI 181
K+E ++ + ++ K ++ SEL+ A RQ +E T QA++
Sbjct: 717 SKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEK 776
Query: 182 -----KAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHA 236
+ R +E R ++ +RE R L EE + + R ERE +Q
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE 836
Query: 237 QRLQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQ 296
+ QLQ+ +QL + + + RR QL+E+ RR
Sbjct: 837 EE-QLQRRERAQQLQEEEDGLQEDQERRRS--------QEQRRDQKWRWQLEEERKRRRH 887
Query: 297 LKIAELSAIIRKLEDRNALLSEERNELLKRVREA------ESQYKPLLDKNKRLSRKNED 350
A+ A+ +L LL EE EL + RE E QY+ + ++L ++ E
Sbjct: 888 TLYAK-PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYR----EEEQLQQEEEQ 942
Query: 351 L----SHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVE 406
L RR E + ++ + ++ ++ + P ++ + RE + +LQ E
Sbjct: 943 LLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEE--ELQQEE 1000
Query: 407 QQNLIDELSKTL----ETAGYVKSVL--ERDKLLRFRKQRKKMAKLPKPVVVETFFGYDE 460
+Q L +E K E K L E ++LLR ++++++ + + E +E
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE 1060
Query: 461 EASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQ 520
E L + + Q EE + +EE E R RQ E + R LQ
Sbjct: 1061 EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQ---ERERQCREEEELQ 1117
Query: 521 EQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQEL 580
++ L ERE + R++L+ + R + ++ E+ L + + + +E + YR +EL
Sbjct: 1118 QEEEQLLREEREKRRRQELERQY-REEEEVQQEEEQLLREEPEKRRRQELERQYREEEEL 1176
Query: 581 VEKIKQM--ETEEARLRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGK-S 637
++ +Q+ E +E R + + R++ EL + + E + + + P +
Sbjct: 1177 QQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVR 1236
Query: 638 PLQVYCEAEG------VTDIVVAELMKKLDI---LGDNANLTNEEQVVVIQARTVLTLAE 688
+VYC+ + D + + + D+ LG+ E++ Q R E
Sbjct: 1237 DNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEE 1296
Query: 689 KWLQQIEETEAALQRKMVDLESEKELF------SKQKGYLDEELDYRKQALDQANKHILE 742
+ L++ E+ EA +R+ + EK+L +++ D + +Q L + + L
Sbjct: 1297 EQLEREEQKEA--KRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLR 1354
Query: 743 LEAM-----LYDALQQEAGAKVAE---LLSEEEREKLKVAVEQWKRQVMSELRERDAQIL 794
+ + QE G K E L +ERE+ + EQ R E + R +
Sbjct: 1355 RQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR 1414
Query: 795 RERMELLQLAQQ----RIKELEERIEAQKRQIKELEEK 828
+ R E QL++Q + +E E+++ Q+R+ K LEE+
Sbjct: 1415 KFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEE 1452
Score = 97.4 bits (241), Expect = 5e-20
Identities = 187/807 (23%), Positives = 339/807 (42%), Gaps = 135/807 (16%)
Query: 38 ELQQEKSKVSKVERE--KNQEL-RQVREHE--QHKTAVLLTELKTKLHEEKMKELQAVRE 92
ELQQE+ ++ ERE + QEL RQ R+ E Q + LL E K ++ +E Q E
Sbjct: 1055 ELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE-RERQCREE 1113
Query: 93 TLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKV 152
L+Q E +LLR ++ E +R Q L R+ E+V+ +EE +K E
Sbjct: 1114 EELQQEEEQLLR----EEREKRRRQELERQYRE--EEEVQQEEEQLLREEPEKRRRQELE 1167
Query: 153 KMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRLM 212
+ +E EL+ Q EE L ++ ++ K + R + +EE+ R K++
Sbjct: 1168 RQYREEEELQ----QEEEQL---LREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQR 1220
Query: 213 EEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAAG 272
++K++ + E+E V+ K +EQ Q+ ++ +++L H G
Sbjct: 1221 SDLKWQ----WEPEKENAVRDNKVYC----KGRENEQFRQLEDSQLRDRQSQQDLQHLLG 1272
Query: 273 AGDASDHSGSPE--QQLDEKDARRFQLKIAELSAIIR---KLEDRNALLSEERNELLKRV 327
D QQ D QL+ E R K ++ LL EER E +R
Sbjct: 1273 EQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRR- 1331
Query: 328 REAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLND 387
+E + +++ + ++L ++ E+ LRR E KF +E Q + L
Sbjct: 1332 QETDRKFR----EEEQLLQEREE--QPLRRQERDRKFREEELRHQEQGRKFLEEEQRLR- 1384
Query: 388 LDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLP 447
+ ERE FLK EQQ E + L +RD+ +FR++ +++++
Sbjct: 1385 ----RQERERKFLK---EEQQLRCQEREQQLRQ--------DRDR--KFREEEQQLSR-- 1425
Query: 448 KPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTM 507
+ + + V Q + E +EE +LR +
Sbjct: 1426 ----------QERDRKFREEEQQVRRQ-------------ERERKFLEEEQQLRQER--- 1459
Query: 508 EYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQ-RAQARIEDL-EKALAEQGQDMK 565
++ + LLQE+ L R+ + R+ L+ E Q R Q R E+ L Q + K
Sbjct: 1460 -HRKFREEEQLLQEREEQQL--HRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERK 1516
Query: 566 WIEEKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAI 625
++EE+Q L+R+ ++ K ++ E+ R E R Q+ +FR E +ER+ +
Sbjct: 1517 FLEEEQQLHRQQRQR----KFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQL 1572
Query: 626 SFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQARTVLT 685
S D K L+ + V ++ + D L +E
Sbjct: 1573 SRQER---DRKFRLE---------EQKVRRQEQERKFMEDEQQLRRQE------------ 1608
Query: 686 LAEKWLQQIEETEAALQRKMVDLESEKELFSKQKG--YLDEELDYRKQALDQANKHILEL 743
++ L+Q + + +++ E++L +++ +L+EE R+Q +Q +H +
Sbjct: 1609 -GQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDR 1667
Query: 744 EAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQL 803
+ + L QE + +L +E K + +Q +RQ ER+ + L+E +L
Sbjct: 1668 KFREEEQLLQEGEEQ--QLRRQERDRKFREEEQQLRRQ------ERERKFLQEEQQL--- 1716
Query: 804 AQQRIKELEERIEAQKRQIKELEEKFL 830
R +ELE + +++ +E E++ L
Sbjct: 1717 ---RRQELERKFREEEQLRQETEQEQL 1740
Score = 97.1 bits (240), Expect = 6e-20
Identities = 195/857 (22%), Positives = 352/857 (41%), Gaps = 155/857 (18%)
Query: 9 RAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKT 68
RA+ D E+L + ED R + +L++E + + +R++ + E + K
Sbjct: 100 RARCDGKESLLQDRRQEEDQR-RFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQ 158
Query: 69 AVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIK------IKDNENQRLQALLSA 122
L + + EE ++ Q +E R+ E E L+ K D E R + LL
Sbjct: 159 ERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLEL 218
Query: 123 LRDGGPEKVKT-------VLLSEAKEEAKKGFEV---EKVKMQQEISELKGAKRQVEEAL 172
R G EK + V E ++E +K V E+ K+Q+E + + ++ EE L
Sbjct: 219 RRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQL 278
Query: 173 TLVIQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQ 232
K++ E+R +++ R+++E +++RR EE + + + ++E Q
Sbjct: 279 R------KLERQELRRERQEEEQQQQRLRRE--QQLRRKQEEERREQQEERREQQERREQ 330
Query: 233 AGHAQRLQL---QKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQL-- 287
+ QL Q+E ++QL + +E +R RRE + + EQQL
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE-----ERREQQLRREQQLRR 385
Query: 288 DEKDARRFQLKIAELSAIIRKLEDRNALLSEE---RNELLKRVREAE--SQYKPLLDKNK 342
+++ R QL+ + ++L L E+ R + L+R +E E Q + +
Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ 445
Query: 343 RLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKL 402
RL R+ E+ L+R E E E +R ++R DQ ++ RE +LKL
Sbjct: 446 RLKREQEERRDWLKREEET------ERHEQERRKQQLKR-------DQEEERRE-RWLKL 491
Query: 403 QIVEQQNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEA 462
+ E++ + R++ LR ++ ++ +L + +EE
Sbjct: 492 EEEERREQQER----------------REQQLRREQEERREQRLKRQ---------EEEE 526
Query: 463 SLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQ 522
L+ Q R++Q ++ E + K E E R Q E Q L+R ++Q
Sbjct: 527 RLQ--------QRLRSEQQLRREQEERREQLLKREEEKRLEQERRE-QRLKREQEERRDQ 577
Query: 523 VGGTLDAEREVKTREQLQAEVQRAQARI--EDLEKALAEQGQDMKWIEEKQALYRRNQEL 580
+ L E E + + + + +R + R+ E++E+ E+ ++ + ++ ++ R Q+L
Sbjct: 578 L---LKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQR-LKREEPEEERRQQL 633
Query: 581 VEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQ 640
++ +Q E + +LR E Q+ R+Q R+ EE ER + H
Sbjct: 634 LKSEEQEERRQQQLRREQQERREQ------RLKREEEEERLEQRLKREH----------- 676
Query: 641 VYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQART-VLTLAEKWLQQIEETEA 699
E E L EEQ QAR + + KW Q+E
Sbjct: 677 ---EEER-----------------REQELAEEEQE---QARERIKSRIPKWQWQLESEAD 713
Query: 700 ALQRKMVDL----ESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEA 755
A Q K+ E ++ +++ E + + Q ++A++ E E Q +A
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA 773
Query: 756 GAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERI 815
K SE R++L R + E RER R E Q +QR EE
Sbjct: 774 EEK-----SERGRQRLSA------RPPLREQRERQL-----RAEERQQREQRFLPEEEEK 817
Query: 816 EAQKRQIKELEEKFLFL 832
E ++RQ +E E++ FL
Sbjct: 818 EQRRRQRREREKELQFL 834
Score = 88.6 bits (218), Expect = 2e-17
Identities = 180/810 (22%), Positives = 320/810 (39%), Gaps = 93/810 (11%)
Query: 38 ELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQ 97
E QQ + + E EK Q RQ RE E K L E + E+ ++LQ + L
Sbjct: 802 ERQQREQRFLPEEEEKEQRRRQRRERE--KELQFLEEEEQLQRRERAQQLQEEEDGLQED 859
Query: 98 HEAELLRVIKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQE 157
E + E +R Q L + + T+ A +E + E+ +Q+E
Sbjct: 860 QERR-------RSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRK---EQQLLQEE 909
Query: 158 ISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKF 217
EL+ +R+ + + + R L QEE +++E E+ R+ E
Sbjct: 910 EEELQREEREKRRR--------QEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYR 961
Query: 218 KDRAVFVLERELGVQAGHAQRLQLQKEAL--DEQLSQVREADRHPGSPRRELPHAAGAGD 275
KD+ + E +L + +R Q +++ +E+L Q E +R
Sbjct: 962 KDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYR 1021
Query: 276 ASDHSGSPEQQL--DEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREAESQ 333
D E+QL +E++ RR Q + + ++ LL EER +R +E E Q
Sbjct: 1022 KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERET--RRRQELERQ 1079
Query: 334 YKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQD 393
Y+ K + L ++ E L +E E R+R R+ +L Q ++
Sbjct: 1080 YR----KEEELQQEEEQL--------------LREEPEKRRRQERERQCREEEELQQEEE 1121
Query: 394 EREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVE 453
+ L+ ++ EL + V+ E ++LLR ++++ +L + E
Sbjct: 1122 QL------LREEREKRRRQELERQYREEEEVQQ--EEEQLLREEPEKRRRQELERQYREE 1173
Query: 454 TFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQ 513
+EE L + + +R + EE + +++ + R+R E Q
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYRE--------EEELQRQKRKQRYRD---EDQRSD 1222
Query: 514 RAYALLQEQVGGTLDAEREVKTRE-----QLQAEVQRAQARIEDLEKALAEQGQDMKWIE 568
+ E+ D + K RE QL+ R + +DL+ L EQ Q+ +
Sbjct: 1223 LKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ-QERDREQ 1281
Query: 569 EKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAISFH 628
E++ +R++ E+ +Q+E EE + + +D + Q E R E+R R+ F
Sbjct: 1282 ERRRWQQRDRHFPEE-EQLEREEQK-EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFR 1339
Query: 629 HTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAE 688
+ + Q E EL + EEQ + Q R L E
Sbjct: 1340 EEEQLLQEREEQPLRRQERDRKFREEELRHQ----EQGRKFLEEEQRLRRQERERKFLKE 1395
Query: 689 KWLQQIEETEAALQ----RKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELE 744
+ + +E E L+ RK + E + + + + +EE R+Q + + LE E
Sbjct: 1396 EQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ---ERERKFLEEE 1452
Query: 745 AMLYDALQQEAGAKVAE---LLSEEEREKLKVAVEQWK---RQVMSELRERDAQILRERM 798
L +QE K E LL E E ++L K + +ERD + RE+
Sbjct: 1453 QQL----RQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKF-REQE 1507
Query: 799 ELLQLAQQRIKELEERIEAQKRQIKELEEK 828
Q +++ E E+++ Q+RQ K L+E+
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRKFLQEE 1537
Score = 84.0 bits (206), Expect = 5e-16
Identities = 169/802 (21%), Positives = 330/802 (41%), Gaps = 102/802 (12%)
Query: 38 ELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQ 97
ELQQE+ ++ + E+EK ++ R+ + E+ EL+ + +++ ++ + R L Q
Sbjct: 1175 ELQQEEEQLLREEQEKRRQERERQYREEE-------ELQRQKRKQRYRD-EDQRSDLKWQ 1226
Query: 98 HEAELLRVIK-----IKDNENQRLQALL-SALRDGGPEKVKTVLLSEAKEEAKKGFEVEK 151
E E ++ K EN++ + L S LRD ++ LL E +E + E E+
Sbjct: 1227 WEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDR---EQER 1283
Query: 152 VKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRL 211
+ QQ ++ ++ ++ K A+ R QEE +++E E + RR
Sbjct: 1284 RRWQQRDRHFPEEEQ---------LEREEQKEAKRRD--RKSQEEKQLLREEREEKRRRQ 1332
Query: 212 MEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAA 271
+ KF++ + ERE + + ++E L Q + + R+E
Sbjct: 1333 ETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKF 1392
Query: 272 GAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREAE 331
+ EQQL + R+F+ + +LS R+ DR E++ +R R+
Sbjct: 1393 LKEEQQLRCQEREQQLRQDRDRKFREEEQQLS---RQERDRKFREEEQQVRRQERERKFL 1449
Query: 332 SQYKPLLDKNKRLSRKNEDL-----SHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLN 386
+ + L + R R+ E L L R E KF+ +E RQ R
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE-----RDRKFR 1504
Query: 387 DLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKL 446
+ + E E FL+ E+Q L + + + L+ ++ LR R++R + +
Sbjct: 1505 EQELRSQEPERKFLE----EEQQLHRQQRQ--------RKFLQEEQQLR-RQERGQQRRQ 1551
Query: 447 PKPVVVETFFGYDEEASLESDGSSVSYQT-DRTDQTPCTPDDDLEEGMAKEETELRFRQL 505
+ + F +E+ E + +S Q DR + E+ + ++E E +F +
Sbjct: 1552 DR----DRKFREEEQLRQEREEQQLSRQERDRKFRLE-------EQKVRRQEQERKFMED 1600
Query: 506 TMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMK 565
+ + + L QE+ + E+ ++ RE+ Q Q + + E L Q ++ +
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQ 1660
Query: 566 WIEEKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAI 625
++ +R ++L++ E EE +LR + +D + + E + R +ERERK
Sbjct: 1661 LRHDRDRKFREEEQLLQ-----EGEEQQLRRQERDRKFREEEQQLR---RQERERK---- 1708
Query: 626 SFHHTPFVDGKSPLQ------VYCEAEGVTDIVVAELMKKLD-----ILGDNANLTNEEQ 674
F+ + L+ + E E + E +++ + + + EEQ
Sbjct: 1709 ------FLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQ 1762
Query: 675 VVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALD 734
+ Q R E+ L+Q E E L+ + D + +E +Q+ EE R Q D
Sbjct: 1763 QLRRQERDRKFREEEQLRQ-EREEQQLRSQESDRKFREEEQLRQER---EEQQLRPQQRD 1818
Query: 735 ---QANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDA 791
+ + L+LE Q+ AE + + + E W+ + +ER+
Sbjct: 1819 GKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERER 1878
Query: 792 QILRERMELLQLAQQRIKELEE 813
++ E + Q +QR +++ E
Sbjct: 1879 KLREEHIRRQQKEEQRHRQVGE 1900
Score = 79.7 bits (195), Expect = 1e-14
Identities = 125/620 (20%), Positives = 264/620 (42%), Gaps = 52/620 (8%)
Query: 26 EDLRAKLTDIQIELQQEKSKVSKVEREKNQEL-RQVREHEQ-----HKTAVLLTELKTKL 79
E AK D + + +++ + + E+ + QE R+ RE EQ + + E K
Sbjct: 1303 EQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKF 1362
Query: 80 HEEKMKELQAVRETLLRQHEAELLRVIK----IKDNENQRLQALLSALRDGGPEKVKTVL 135
EE+++ + R+ L + E L R + +K+ + R Q LR K +
Sbjct: 1363 REEELRHQEQGRKFL--EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEE 1420
Query: 136 LSEAKEEAKKGF--EVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLH 193
+++E + F E ++V+ Q+ + ++Q+ + + ++ E R LH
Sbjct: 1421 QQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQE-REEQQLH 1479
Query: 194 QEEITRIKKECEREIRRLMEEIKFKDRAVFVLE--RELGVQAGHAQRLQLQKEALDEQLS 251
++E R E E+++RR + KF+++ + E R+ + R Q Q++ L E+
Sbjct: 1480 RQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEE-Q 1538
Query: 252 QVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDA-RRFQL---KIAELSAIIR 307
Q+R +R G RR+ + EQQL ++ R+F+L K+ +
Sbjct: 1539 QLRRQER--GQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERK 1596
Query: 308 KLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQ 367
+ED L +E + L++ R+ + + ++++L ++ E+ L R E KF+ +
Sbjct: 1597 FMEDEQQLRRQEGQQQLRQERDRKFR------EDEQLLQEREE--QQLHRQERDRKFLEE 1648
Query: 368 E-NIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKS 426
E + ++R +R ++ Q +E + +L+ E+ E + L +
Sbjct: 1649 EPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK 1708
Query: 427 VLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRT---DQTPC 483
L+ ++ LR ++ +K F +E+ E++ + Q ++
Sbjct: 1709 FLQEEQQLRRQELERK-------------FREEEQLRQETEQEQLRRQERYRKILEEEQL 1755
Query: 484 TPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEV 543
P+ + E+ + ++E + +FR+ Q + QE + E+ + RE+ Q
Sbjct: 1756 RPERE-EQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRP 1814
Query: 544 QRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQDARD 603
Q+ + E+ L + Q+ + +E+ YR ++ + K E+ + E Q R
Sbjct: 1815 QQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQ 1874
Query: 604 QNE--LLEFRILELEERERK 621
+ E L E I ++ E++
Sbjct: 1875 ERERKLREEHIRRQQKEEQR 1894
Score = 54.3 bits (129), Expect = 5e-07
Identities = 97/465 (20%), Positives = 194/465 (41%), Gaps = 67/465 (14%)
Query: 8 SRAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHK 67
SR + D+ Q ++ K + + +L+QE+ + + E + QE + + H Q +
Sbjct: 1424 SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER 1483
Query: 68 TAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGG 127
L E + +E+ ++ RE LR E E R ++ + R Q L++
Sbjct: 1484 DRKFLEEEQQLRRQERDRKF---REQELRSQEPE--RKFLEEEQQLHRQQRQRKFLQEEQ 1538
Query: 128 PEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIR 187
+ + ++ +K E E+++ ++E +L +R + L + K++ E
Sbjct: 1539 QLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRL----EEQKVRRQEQE 1594
Query: 188 SVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALD 247
+ ++++ R +E ++++R+ + KF++ + ERE R + ++ L+
Sbjct: 1595 RKFMEDEQQLRR--QEGQQQLRQERDR-KFREDEQLLQERE----EQQLHRQERDRKFLE 1647
Query: 248 EQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQL----DEKDARRFQ--LKIAE 301
E+ Q+R +R ++L H D E+QL +E+ RR + K E
Sbjct: 1648 EE-PQLRRQER-----EQQLRH------DRDRKFREEEQLLQEGEEQQLRRQERDRKFRE 1695
Query: 302 LSAIIRKLEDRNALLSEE----RNELLKRVREAE--------------SQYKPLLDKNKR 343
+R+ E L EE R EL ++ RE E +Y+ +L++ +
Sbjct: 1696 EEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQL 1755
Query: 344 LSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSS---LNDLDQSQDEREVDFL 400
+ E LRR E KF +E + + +R S + +Q + ERE L
Sbjct: 1756 RPEREE---QQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQL 1812
Query: 401 KLQIVEQQNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAK 445
+ Q + + +E LE E+++ LR + R+ A+
Sbjct: 1813 RPQQRDGKYRWEEEQLQLE---------EQEQRLRQERDRQYRAE 1848
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 116 bits (290), Expect = 1e-25
Identities = 186/831 (22%), Positives = 353/831 (42%), Gaps = 148/831 (17%)
Query: 52 EKNQELRQVREH-EQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKD 110
E +E+ ++E E+ K + TE K K EEKM L + L Q +AE + ++
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEE 907
Query: 111 NENQRLQALLSALRDGGPEKVKTVL-LSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVE 169
+Q ++ + K+K V +E +EE +K K++ E SEL K+ ++
Sbjct: 908 RCDQLIKTKIQL-----EAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL---KKDID 959
Query: 170 EALTLVIQADKIKAAEIRSVYHLHQE---------EITRIKKECEREIRRLMEEIKFKDR 220
+ + + +K K A V +L +E ++T+ KK + ++ +++++ ++
Sbjct: 960 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1019
Query: 221 AVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELP-HAAGAGDASDH 279
V L + +L+ Q + L+ L Q ++ +R+L A +++
Sbjct: 1020 KVNTLTKA-------KIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMD 1072
Query: 280 SGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNAL---LSEERNELLKRVREAESQYKP 336
+ +QQLDEK + K E+S + K+ED AL L ++ EL R+ E E + +
Sbjct: 1073 IENDKQQLDEK----LKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEA 1128
Query: 337 LLDKNKRLSRKNEDLSHALRRMENKLK---FVTQENIEMRQR------------------ 375
+ ++ DLS L + +L+ T IEM ++
Sbjct: 1129 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188
Query: 376 ----AGIIRR--PSSLNDLDQSQD--EREVDFLKLQIVEQQNLIDELSKTLETAGYVKSV 427
A +R+ S+ +L + D +R L+ + E + ID+L+ +ET K
Sbjct: 1189 HEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGN 1248
Query: 428 LER------DKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQT 481
LE+ D+L + + ++ +L + + A L+++ S Q D D T
Sbjct: 1249 LEKMCRALEDQLSEIKTKEEEQQRLINDLTA-------QRARLQTESGEYSRQLDEKD-T 1300
Query: 482 PCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQA 541
+ ++ ++ EL+ RQL E +A LQ + + ++ +A
Sbjct: 1301 LVSQLSRGKQAFTQQIEELK-RQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKA 1359
Query: 542 EVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQDA 601
E+QRA + KA +E Q W + + + +++ +++E + +L +QDA
Sbjct: 1360 ELQRA------MSKANSEVAQ---WRTKYET------DAIQRTEELEEAKKKLAQRLQDA 1404
Query: 602 RDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLD 661
+ E + + LE+ +++ LQ V D+++ D
Sbjct: 1405 EEHVEAVNAKCASLEKTKQR-----------------LQ-----NEVEDLMI-------D 1435
Query: 662 ILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGY 721
+ NA ++ + R + +W Q+ EET A L+ + S K K
Sbjct: 1436 VERTNAACAALDK----KQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNA 1491
Query: 722 LDEELDYRKQALDQANKHILELEAMLYDALQQ--EAGAKVAELLSEEEREKLKVAVEQWK 779
+E LD + + L + NK+ L+ + D +Q E G ++ EL EK+K VEQ K
Sbjct: 1492 YEESLD-QLETLKRENKN---LQQEISDLTEQIAEGGKRIHEL------EKIKKQVEQEK 1541
Query: 780 RQVMSELRERDA-------QILRERMELLQL---AQQRIKELEERIEAQKR 820
++ + L E +A +ILR ++EL Q+ ++I E +E I+ KR
Sbjct: 1542 SELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKR 1592
Score = 97.4 bits (241), Expect = 5e-20
Identities = 195/899 (21%), Positives = 380/899 (42%), Gaps = 152/899 (16%)
Query: 9 RAKGDKAEALAA----LQAANEDLRAKLTD---IQIELQQEKSKVS---KVEREKNQEL- 57
+A+ DK L L+ +DL L I+++L++ K K+ K+ +E ++
Sbjct: 1015 QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIE 1074
Query: 58 --RQVREHEQHKTAVLLTELKTKLHEE---------KMKELQAVRETLLRQHEAELL--- 103
+Q + + K ++ L++K+ +E K+KELQA E L + EAE
Sbjct: 1075 NDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRA 1134
Query: 104 RVIKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKG 163
+ K + + ++ L+ + L + G + A+ E K E E KM++++ E
Sbjct: 1135 KAEKQRSDLSRELEEISERLEEAGGA-------TSAQIEMNKKREAEFQKMRRDLEE--- 1184
Query: 164 AKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVF 223
A Q E + + AE+ + + R+K++ E+E + EI +
Sbjct: 1185 ATLQHEATAATLRKKHADSVAELGEQI----DNLQRVKQKLEKEKSEMKMEIDDLASNME 1240
Query: 224 VLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSP 283
+ + G L+ AL++QLS+++ + +L A SG
Sbjct: 1241 TVSKAKG-------NLEKMCRALEDQLSEIKTKEEEQQRLINDL--TAQRARLQTESGEY 1291
Query: 284 EQQLDEKDARRFQLK------IAELSAIIRKLEDR--------NALLSEERN-ELLKRVR 328
+QLDEKD QL ++ + R+LE+ +AL S + +LL+
Sbjct: 1292 SRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQY 1351
Query: 329 EAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDL 388
E E + K L + +S+ N +++ + E T+E E +++ L D
Sbjct: 1352 EEEQEAKAELQR--AMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA-----QRLQDA 1404
Query: 389 DQSQDEREVDFLKLQIVEQ--QNLIDELSKTLETAGYVKSVLER-----DKLLRFRKQRK 441
++ + L+ +Q QN +++L +E + L++ DK+L KQ+
Sbjct: 1405 EEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKC 1464
Query: 442 KMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELR 501
EE E + S ++ T+ + EE + + ET
Sbjct: 1465 ------------------EETHAELEASQKESRSLSTELFKIK--NAYEESLDQLET--- 1501
Query: 502 FRQLTMEYQALQRAYALLQEQV--GGTLDAEREVKTREQLQAEVQRAQARIEDLEKALA- 558
L E + LQ+ + L EQ+ GG E E K ++Q++ E QA +E+ E +L
Sbjct: 1502 ---LKRENKNLQQEISDLTEQIAEGGKRIHELE-KIKKQVEQEKSELQAALEEAEASLEH 1557
Query: 559 EQGQ----DMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQ-----DARDQNELLE 609
E+G+ ++ + K + R+ E E+I QM+ R+ +Q + R +N+ +
Sbjct: 1558 EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAI- 1616
Query: 610 FRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANL 669
R+ + E + I +H + ++ L+ Y + + +K + D+A
Sbjct: 1617 -RLKKKMEGDLNEMEIQLNHANRMAAEA-LRNYRNTQAI--------LKDTQLHLDDALR 1666
Query: 670 TNE---EQVVVIQARTVLTLAE-----KWLQQIEETEAALQRKMVDLESEKELFSKQKGY 721
+ E EQ+ +++ R L AE L+Q E + +++++D +L Q
Sbjct: 1667 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1726
Query: 722 LDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVA---------ELLSEEER---- 768
L ++ +K+ ++ E+E ++ +A E AK A EL E++
Sbjct: 1727 L---INTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1783
Query: 769 EKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEA-QKRQIKELE 826
E++K +EQ + + L E + L+ + +Q + R++ELE +E+ QKR ++ ++
Sbjct: 1784 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVK 1842
Score = 97.4 bits (241), Expect = 5e-20
Identities = 179/876 (20%), Positives = 380/876 (43%), Gaps = 128/876 (14%)
Query: 5 GMSSRAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVRE-H 63
G+ S+ + ++A + LQ ++L+A++ +++ E++ E++ +K E++++ R++ E
Sbjct: 1093 GLQSKIEDEQALGMQ-LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS 1151
Query: 64 EQHKTAVLLTELKTKLHEEKMKELQAVRETLLR---QHEAELLRVIKIKDNENQRLQALL 120
E+ + A T + ++++++ E Q +R L QHEA + K + L +
Sbjct: 1152 ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI 1211
Query: 121 SALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQE-ISELKGAKRQVEEALTLVIQAD 179
L ++VK L KE+++ E++ + E +S+ KG ++ AL +
Sbjct: 1212 DNL-----QRVKQKL---EKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEI 1263
Query: 180 KIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRL 239
K K E + + + + R++ E R+L E KD V L R G QA Q++
Sbjct: 1264 KTKEEEQQRLINDLTAQRARLQTESGEYSRQLDE----KDTLVSQLSR--GKQA-FTQQI 1316
Query: 240 QLQKEALDEQ------LSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDAR 293
+ K L+E+ L+ ++ RH RE + + ++ + + ++
Sbjct: 1317 EELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYE-----EEQEAKAELQRAMSKANSE 1371
Query: 294 RFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPL------LDKNK-RLSR 346
Q + + I++ E+ L E + +L +R+++AE + + L+K K RL
Sbjct: 1372 VAQWRTKYETDAIQRTEE----LEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQN 1427
Query: 347 KNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVE 406
+ EDL + R + ++ + ++ + ++E L ++ +
Sbjct: 1428 EVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFK 1487
Query: 407 QQNLIDELSKTLETAGYVKSVLERD------KLLRFRKQRKKMAKLPKPVVVETFFGYDE 460
+N +E LET L+++ ++ K+ ++ K+ K V E +
Sbjct: 1488 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKS---EL 1544
Query: 461 EASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQ 520
+A+LE +S+ ++ + + LE K E + + + E ++R + +
Sbjct: 1545 QAALEEAEASLEHEEGKILRI------QLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIV 1598
Query: 521 EQVGGTLDAERE-----VKTREQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALY- 574
E + TLDAE ++ +++++ ++ + ++ + AE ++ + QA+
Sbjct: 1599 ESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYR---NTQAILK 1655
Query: 575 ----------RRNQELVEKIKQMETEEARLRHEVQDAR---DQNE----LLEFRILELEE 617
R ++L E++ +E L+ E+++ R +Q E + E +L+ E
Sbjct: 1656 DTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1715
Query: 618 RERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVV 677
R + + +T ++ K L+ TDI I G+ ++ E +
Sbjct: 1716 RVQ---LLHTQNTSLINTKKKLE--------TDIS--------QIQGEMEDIIQEARNAE 1756
Query: 678 IQARTVLTLAEKWLQQI---EETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQ-AL 733
+A+ +T A +++ ++T A L+R +LE + L LD +Q AL
Sbjct: 1757 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK-------DLQHRLDEAEQLAL 1809
Query: 734 DQANKHILELEAMLYDALQQEAGAKVAELLSEEERE-KLKVAVEQWKRQVMSELRERDAQ 792
K I +LEA +V EL E E E K V + R+ +++E Q
Sbjct: 1810 KGGKKQIQKLEA------------RVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQ 1857
Query: 793 ILRERMELLQLAQQRIKELEERIEAQKRQIKELEEK 828
+R +L+L Q + +L+ ++++ KRQ +E EE+
Sbjct: 1858 TEEDRKNILRL-QDLVDKLQAKVKSYKRQAEEAEEQ 1892
Score = 68.2 bits (165), Expect = 3e-11
Identities = 141/662 (21%), Positives = 286/662 (43%), Gaps = 119/662 (17%)
Query: 194 QEEITRIKKECEREIRRLME-EIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQ 252
++E+ +K+E E+ L + E K K+ LE ++ LQLQ +A + L+
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEAKRKE-----LEEKMVTLMQEKNDLQLQVQAEADSLAD 904
Query: 253 VREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDR 312
E R + ++ A + + E+ DE++ AEL+A RKLED
Sbjct: 905 AEE--RCDQLIKTKIQLEAKIKEVT------ERAEDEEEIN------AELTAKKRKLEDE 950
Query: 313 NALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEM 372
+ L ++ ++L + + E + +K K L+ + L + ++ + K + + +
Sbjct: 951 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH--- 1007
Query: 373 RQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDK 432
+L+DL +D +V+ L ++ + +D+L +LE ++ LER K
Sbjct: 1008 ---------QQTLDDLQAEED--KVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAK 1056
Query: 433 LLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEG 492
RK L + +E+D L+E
Sbjct: 1057 -------RKLEGDLK--------LAQESTMDIEND------------------KQQLDEK 1083
Query: 493 MAKEETELRFRQLTMEYQ-----ALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRA- 546
+ K+E E+ Q +E + LQ+ LQ ++ L+ E E + + +AE QR+
Sbjct: 1084 LKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARI-EELEEEIEAERASRAKAEKQRSD 1142
Query: 547 -QARIEDLEKALAEQG----QDMKWIEEKQALYRR-NQELVEKIKQMETEEARLRHE--- 597
+E++ + L E G ++ ++++A +++ ++L E Q E A LR +
Sbjct: 1143 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1202
Query: 598 -VQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAEL 656
V + +Q + L+ R+ + E+E+ + D S ++ +A+G + + L
Sbjct: 1203 SVAELGEQIDNLQ-RVKQKLEKEKSEMKMEID-----DLASNMETVSKAKGNLEKMCRAL 1256
Query: 657 MKKLDILGDNANLTNEEQVVV----IQARTVLTLAEKWLQQIEETEAALQRKMVDLESEK 712
D L + E+Q ++ Q + T + ++ +Q++E + + + L K
Sbjct: 1257 E---DQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQ----LSRGK 1309
Query: 713 ELFSKQ----KGYLDEELDYRKQALD---QANKHILELEAMLYDALQQEAGAKVAELLSE 765
+ F++Q K L+EE+ K AL Q+++H +L Y+ +QEA A++ +S+
Sbjct: 1310 QAFTQQIEELKRQLEEEIK-AKSALAHALQSSRHDCDLLREQYEE-EQEAKAELQRAMSK 1367
Query: 766 EEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKEL 825
E V QW+ + ++ +R ++ + +L QR+++ EE +EA + L
Sbjct: 1368 ANSE-----VAQWRTKYETDAIQRTEELEEAKKKL----AQRLQDAEEHVEAVNAKCASL 1418
Query: 826 EE 827
E+
Sbjct: 1419 EK 1420
Score = 58.9 bits (141), Expect = 2e-08
Identities = 81/410 (19%), Positives = 172/410 (41%), Gaps = 29/410 (7%)
Query: 6 MSSRAKGDKAEALAALQAANEDLR---AKLTDIQIELQQEKSKVSKVEREKNQELRQVRE 62
+ + + +K+E AAL+ A L K+ IQ+EL Q KS+V + EK++E+ Q++
Sbjct: 1533 IKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKR 1592
Query: 63 HE----QHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQA 118
+ + + L E++++ ++K+ E L + E +L ++ + +
Sbjct: 1593 NHIRIVESMQSTLDAEIRSRNDAIRLKKKM---EGDLNEMEIQLNHANRMAAEALRNYRN 1649
Query: 119 LLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQA 178
+ L+D + E +E E +Q EI EL+ Q E + + Q
Sbjct: 1650 TQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ- 1708
Query: 179 DKIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQR 238
+ + A+E + H + KK+ E +I ++ E++ + +E A++
Sbjct: 1709 ELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEME-------DIIQEARNAEEKAKK 1761
Query: 239 LQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLK 298
+ E+L + ++ H ++ L H +QL K ++ +
Sbjct: 1762 AITDAAMMAEELKKEQDTSAHLERMKKNLEQTV---KDLQHRLDEAEQLALKGGKK---Q 1815
Query: 299 IAELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRM 358
I +L A +R+LE + E +K +R+ E + K L + + + L + ++
Sbjct: 1816 IQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKL 1875
Query: 359 ENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQ 408
+ K+K ++ E +++ + +L+ + Q E E + I E Q
Sbjct: 1876 QAKVKSYKRQAEEAEEQSNV-----NLSKFRRIQHELEEAEERADIAESQ 1920
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 115 bits (287), Expect = 2e-25
Identities = 195/921 (21%), Positives = 381/921 (41%), Gaps = 135/921 (14%)
Query: 13 DKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
++ E + L A +L K + ++ ++ + ++KVE+EK+ +V+ + TA L
Sbjct: 932 EEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTA--L 989
Query: 73 TELKTKLHEEKMKELQAVRETL--LRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEK 130
E +KL +EK +A ++TL L+ E ++ +IKI Q+ L +G E+
Sbjct: 990 EENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDL-----EGSLEQ 1044
Query: 131 VKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVY 190
K L E AK+ E + Q+ I +L+ K+Q+EE L K K E+ +
Sbjct: 1045 EKK--LRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKL-------KKKEFELSQLQ 1095
Query: 191 ------HLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGH----AQRLQ 240
+H + + KE + I L EEI+ + +E++ A ++RL+
Sbjct: 1096 AKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLE 1155
Query: 241 LQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDA---------SDHSGSPEQQLD--E 289
A Q+ ++ + RR+L A +A +D +Q+D +
Sbjct: 1156 EASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQ 1215
Query: 290 KDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNK------- 342
+ ++ + + +EL I + LS+ ++ + + R E Q+ + K++
Sbjct: 1216 RVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH 1275
Query: 343 -------RLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQS---- 391
RL +N +LSH + E+ + +T+ + Q+ ++R ++
Sbjct: 1276 DLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAH 1335
Query: 392 ---QDEREVDFLKLQIVEQQNLIDELSKTLETA----GYVKSVLERDKLLR---FRKQRK 441
+ D L+ Q E+Q EL + L A ++ E D + R + +K
Sbjct: 1336 ALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1395
Query: 442 KMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTD------RTDQTPCTPDDDLEEGMAK 495
K+A+ + T + ASLE + + + T C D + K
Sbjct: 1396 KLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDK 1455
Query: 496 --EETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTR-EQLQAEVQRAQARIED 552
E + + + E +A Q+ L ++ +A EV + E L+ E + Q I D
Sbjct: 1456 VLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISD 1515
Query: 553 LEKALAEQGQDMKWIEEKQALYRRN----QELVEKIK-QMETEEARLRHEVQDARDQNEL 607
L + +AE G++++ E+ + L + Q +E+++ +E EE+++ +
Sbjct: 1516 LTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSE 1575
Query: 608 LEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNA 667
L+ +++E +E + S LQ +AE + L KK++ GD
Sbjct: 1576 LDRKVIEKDEEIEQLKRNSQR------AAEALQSVLDAEIRSRNDALRLKKKME--GD-- 1625
Query: 668 NLTNEEQVVVIQARTVLTLAEKWLQ----QIEETEAALQ---RKMVDLESEKELFSKQKG 720
NE ++ + + + +K L+ Q+++++ L R DL+ + + ++ G
Sbjct: 1626 --LNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNG 1683
Query: 721 YLDEELDYRKQALDQANKHILELEAMLYDA----------------LQQEAGAKVAELLS 764
L EEL+ K AL+Q + E L DA +++ A +A+ +
Sbjct: 1684 LLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQA 1743
Query: 765 EEE---------REKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERI 815
E E EK K A+ +E+D ERM+ + +Q +K+L+ R+
Sbjct: 1744 EVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK--KNLEQTVKDLQHRL 1801
Query: 816 E--------AQKRQIKELEEK 828
+ K+QI++LE +
Sbjct: 1802 DEAEQLALKGGKKQIQKLENR 1822
Score = 90.9 bits (224), Expect = 4e-18
Identities = 147/790 (18%), Positives = 335/790 (42%), Gaps = 121/790 (15%)
Query: 130 KVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSV 189
K+K +L S E+ + + + ++E++ + ++++EE + ++Q +++S
Sbjct: 839 KIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQS- 897
Query: 190 YHLHQEEITRIKKECEREIR-RLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDE 248
E + ++ CE I+ +++ E K K+ +RL+ ++E E
Sbjct: 898 ---ETENLMDAEERCEGLIKSKILLEAKVKEL---------------TERLEEEEEMNSE 939
Query: 249 QLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRK 308
+++ R + S +R++ + + E+ E + ++ L I K
Sbjct: 940 LVAKKRNLEDKCSSLKRDIDDL----ELTLTKVEKEKHATENKVKNLSEEMTALEENISK 995
Query: 309 LEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHAL------------- 355
L L E + L ++ E + L+ N +L ++ +DL +L
Sbjct: 996 LTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERA 1055
Query: 356 -RRMENKLKFVTQ-----ENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQ--IVEQ 407
R++E LK + EN + + + ++ L+ L D+ +V L+ Q I E
Sbjct: 1056 KRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKEL 1115
Query: 408 QNLIDELSKTLETAGYVKSVLERDKL-----LRFRKQRKKMAKLPKPVVVETFFGYD--- 459
Q I+EL + +E +++ +E+ + L +R + A +E +
Sbjct: 1116 QARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEF 1175
Query: 460 -------EEASLESDGSSVSYQTDRTDQTPCTPD--DDLE---EGMAKEETELRFR--QL 505
EEA+L+ + ++ + + + D + D+L+ + + KE++EL+ +
Sbjct: 1176 QKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDM 1235
Query: 506 TMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQA----EVQRAQARIEDLEKALAEQG 561
+AL ++ + ++ D E+K +++ Q ++ +AR++ L+ +
Sbjct: 1236 ASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRV 1295
Query: 562 QDMKWI-----EEKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELE 616
++ + + + KQAL ++ +EL ++++ + + H +Q +R +LL + E +
Sbjct: 1296 EEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQ 1355
Query: 617 ERERK-SPAISFHHTPFVDGKSPLQV-YCEAEGVTDIVVAELMKKLDILGDNANLTNEEQ 674
E + + A+S ++ ++ + + + +L ++L +N N +
Sbjct: 1356 EAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKC 1415
Query: 675 VVVIQARTVL-------------------TLAEK----------WLQQIEETEAALQRKM 705
+ + + L TL +K W Q+++E++A L+
Sbjct: 1416 ASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQ 1475
Query: 706 VDLES-EKELFSKQKGYLDEELDYRKQALDQANKHILE----LEAMLYDALQQEAGAKVA 760
+ S ELF + Y EE+ + + L + NK++ E L + + + A+
Sbjct: 1476 KESRSLSTELFKMRNAY--EEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKT 1533
Query: 761 ELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQ---RIKELEERIEA 817
+ L E+E+ L+VA+E +V L +++ILR ++EL Q+ + ++ E +E IE
Sbjct: 1534 KKLVEQEKSDLQVALE----EVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQ 1589
Query: 818 QKRQIKELEE 827
KR + E
Sbjct: 1590 LKRNSQRAAE 1599
Score = 72.4 bits (176), Expect = 2e-12
Identities = 174/853 (20%), Positives = 344/853 (40%), Gaps = 146/853 (17%)
Query: 26 EDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVRE-HEQHKTAVLLTELKTKLHEEKM 84
++L+A++ +++ E++ E + +K+E++++ R++ E E+ + A T + ++++++
Sbjct: 1113 KELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKRE 1172
Query: 85 KELQAVRETLLR---QHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKE 141
E Q +R L QHEA + K + + L + L ++VK L E
Sbjct: 1173 AEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNL-----QRVKQKL-----E 1222
Query: 142 EAKKGFEVEKVKMQQEISELKGAKRQVEEAL-TLVIQADKIKAAEIRSVYHLHQEEITRI 200
+ K ++E M I L +K +E T+ Q +IKA + + +H ++
Sbjct: 1223 KEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH--DLNMQ 1280
Query: 201 KKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHP 260
K + + L ++ K+ + +L K+AL +QL +++
Sbjct: 1281 KARLQTQNGELSHRVEEKESLI--------------SQLTKSKQALTQQLEELKRQMEEE 1326
Query: 261 GSPRRELPHAAGAG----DASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLE----DR 312
+ + HA + D EQ+ + R +E++ K E R
Sbjct: 1327 TKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQR 1386
Query: 313 NALLSEERNELLKRVREAESQYKPL------LDKNK-RLSRKNEDLSHALRRMENKLKFV 365
L E + +L +R++EAE + L+K K RL + EDL L R
Sbjct: 1387 TEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACA-- 1444
Query: 366 TQENIEMRQRAGIIRRPSSLNDLDQSQDE-----REVDFLKLQIVEQQNLIDELSKTLET 420
++ +QR LD+SQ E +E L ++ + +N +E+ LET
Sbjct: 1445 ---TLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLET 1501
Query: 421 ------------AGYVKSVLERDKLLRFRKQRKKMAKLPKP---VVVETFFGYDEEASLE 465
+ + + E K L+ ++ KK+ + K V +E + E SLE
Sbjct: 1502 LRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALE-----EVEGSLE 1556
Query: 466 SDGSSV-------SYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYAL 518
+ S + S D+ D+++E+ + Q ++ + R AL
Sbjct: 1557 HEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDAL 1616
Query: 519 -LQEQVGGTLDAEREV------KTREQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQ 571
L++++ G L+ E E+ + + Q ++ Q +++D + L + + + ++E+
Sbjct: 1617 RLKKKMEGDLN-EMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQL 1675
Query: 572 ALY-RRNQELVEKIKQM-----ETEEARL--RHEVQDARDQNELLEFRILELEERERKSP 623
A+ RRN L+E++++M +TE R E+ DA D+ +LL + L ++K
Sbjct: 1676 AIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLE 1735
Query: 624 AISFHHTPFVDGKSPLQVYCEAEG---VTD--IVVAELMKKLDILGDNANLTN--EEQVV 676
A V+ E + +TD ++ EL K+ D + E+ V
Sbjct: 1736 ADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 1795
Query: 677 VIQART------VLTLAEKWLQQIEETEAALQRKMVDLESEK-----------ELFSKQK 719
+Q R L +K +Q++E L+ ++ D+E ++ E K+
Sbjct: 1796 DLQHRLDEAEQLALKGGKKQIQKLENRVRELENEL-DVEQKRGAEALKGAHKYERKVKEM 1854
Query: 720 GYLDEE-------------------LDYRKQALD---QANKHILELEAMLYDALQQEAGA 757
Y EE Y++QA + QAN + + ++ + A
Sbjct: 1855 TYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERA 1914
Query: 758 KVAELLSEEEREK 770
+AE + R K
Sbjct: 1915 DIAESQVNKLRAK 1927
Score = 57.0 bits (136), Expect = 7e-08
Identities = 77/399 (19%), Positives = 162/399 (40%), Gaps = 20/399 (5%)
Query: 11 KGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAV 70
K D AL ++ + E +K+ +Q+EL Q KS++ + EK++E+ Q++ + Q
Sbjct: 1541 KSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEA 1600
Query: 71 LLTELKTKLHEEK-MKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPE 129
L + L ++ L+ E L + E +L + + L+ + L+D
Sbjct: 1601 LQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLH 1660
Query: 130 KVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSV 189
+ +E +E E + +E+ E+K A Q E L Q + + A++ +
Sbjct: 1661 LDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQ-ELLDASDRVQL 1719
Query: 190 YHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQ 249
H + KK+ E +I + E++ + E + A++ + E+
Sbjct: 1720 LHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEK-------AKKAITDAAMMAEE 1772
Query: 250 LSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKL 309
L + ++ H ++ L H +QL K ++ +I +L +R+L
Sbjct: 1773 LKKEQDTSAHLERMKKNLEQTV---KDLQHRLDEAEQLALKGGKK---QIQKLENRVREL 1826
Query: 310 EDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQEN 369
E+ + + E LK + E + K + + + + L + +++ K+K ++
Sbjct: 1827 ENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQA 1886
Query: 370 IEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQ 408
E ++A + L+ + Q E E + I E Q
Sbjct: 1887 EEAEEQAN-----TQLSRCRRVQHELEEAAERADIAESQ 1920
Score = 46.2 bits (108), Expect = 1e-04
Identities = 61/286 (21%), Positives = 111/286 (38%), Gaps = 42/286 (14%)
Query: 9 RAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKT 68
R+ D E LA ++ N L +L ++++ L+Q + R QEL + Q
Sbjct: 1666 RSNEDLKEQLAIVERRNGLLLEELEEMKVALEQ----TERTRRLSEQELLDASDRVQ--- 1718
Query: 69 AVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGP 128
LL T L K K E + Q +AE+ I+ N ++ + ++
Sbjct: 1719 --LLHSQNTSLINTKKK-----LEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAE 1771
Query: 129 EKVKTVLLSEAKEEAKKGFEVEKVKMQQEISE-----LKGAKRQVEEALTLV------IQ 177
E K S E KK E +Q + E LKG K+Q+++ V +
Sbjct: 1772 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELD 1831
Query: 178 ADKIKAAEIRSVYHLHQEEITRIKKECERE----------IRRLMEEIKFKDRAVFVLER 227
++ + AE H ++ ++ + + E + + +L ++K R E
Sbjct: 1832 VEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1891
Query: 228 ELGVQAGHAQRLQLQKEALDE-------QLSQVREADRHPGSPRRE 266
+ Q +R+Q + E E Q++++R R GS + E
Sbjct: 1892 QANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937
Score = 31.6 bits (70), Expect = 3.2
Identities = 29/120 (24%), Positives = 54/120 (45%), Gaps = 24/120 (20%)
Query: 709 ESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEER 768
E+EKE+ + + E+ + K+ L ++ ELE + LQ++ +L + E
Sbjct: 848 EAEKEMAT-----MKEDFERTKEELARSEARRKELEEKMVSLLQEKNDL---QLQVQSET 899
Query: 769 EKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEK 828
E L A E+ + + S++ L + ++KEL ER+E ++ EL K
Sbjct: 900 ENLMDAEERCEGLIKSKI----------------LLEAKVKELTERLEEEEEMNSELVAK 943
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 110 bits (274), Expect = 7e-24
Identities = 196/931 (21%), Positives = 380/931 (40%), Gaps = 142/931 (15%)
Query: 13 DKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
D+ E A L A L + ++++ ++ + ++KVE+EK+ +V+ + L
Sbjct: 928 DEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAG--L 985
Query: 73 TELKTKLHEEKMKELQAVRETL--LRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEK 130
E+ KL +EK +A ++ L L+ E ++ + K K Q++ L +G E+
Sbjct: 986 DEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDL-----EGSLEQ 1040
Query: 131 VKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEE----------ALTLVIQADK 180
K V + E AK+ E + Q+ I +L+ K+Q++E AL I+ ++
Sbjct: 1041 EKKVRMD--LERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQ 1098
Query: 181 IKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLER--ELGVQAGHAQR 238
++++ Q I +++E E E + K + LE E +AG A
Sbjct: 1099 ALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATS 1158
Query: 239 LQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLD---------E 289
+Q++ E Q D + + E AA +D +Q+D E
Sbjct: 1159 VQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE 1218
Query: 290 KDARRFQLKIAELSA----IIR---KLEDRNALLSEERNELLKRVREAESQYKPLLDKNK 342
K+ F+L++ ++++ II+ LE L ++ NE + E + L +
Sbjct: 1219 KEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRA 1278
Query: 343 RLSRKNEDLSHALRRME--------NKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDE 394
+L +N +LS L E KL + Q RQ ++ ++L QS
Sbjct: 1279 KLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSA-R 1337
Query: 395 REVDFLKLQIVEQQNLIDELSKTLETA----GYVKSVLERDKLLRFRKQRKKMAKLPKPV 450
+ D L+ Q E+ EL + L A ++ E D + R + + KL + +
Sbjct: 1338 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1397
Query: 451 --VVETFFGYDEEAS--------LESDGSSVSYQTDRTDQTPCTPD-------------- 486
E + + S L+++ + +R++ D
Sbjct: 1398 QEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWK 1457
Query: 487 DDLEEGMAK-EETELRFRQLTMEYQALQRAY---------------------ALLQEQVG 524
EE ++ E ++ R L+ E L+ AY + L EQ+G
Sbjct: 1458 QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1517
Query: 525 GTLDAEREV-KTREQLQAEVQRAQARIEDLEKALA-EQGQ----DMKWIEEKQALYRRNQ 578
+ E+ K R+QL+AE Q+ +E+ E +L E+G+ +++ + K + R+
Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA 1577
Query: 579 ELVEKIKQMETEEARLRHEVQ-----DARDQNELLEFRILELEERERKSPAISFHHTPFV 633
E E+++Q + R+ +Q + R +NE L R+ + E + I H +
Sbjct: 1578 EKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEAL--RVKKKMEGDLNEMEIQLSHANRM 1635
Query: 634 DGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNE---EQVVVIQARTVLTLAE-- 688
++ QV + L+K I D+A N+ E + +++ R L AE
Sbjct: 1636 AAEAQKQVKS---------LQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELE 1686
Query: 689 ---KWLQQIEETEAALQRKMVD-------LESEKELFSKQKGYLDEELDYRKQALDQANK 738
++Q E + ++++++ L S+ QK +D +L + +++A +
Sbjct: 1687 ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ 1746
Query: 739 HILELEAMLYDALQQEAGAKVAELLSEEE-----REKLKVAVEQWKRQVMSELRERDAQI 793
E A+ A +AE L +E+ E++K +EQ + + L E +
Sbjct: 1747 ECRNAEEKAKKAITD--AAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIA 1804
Query: 794 LRERMELLQLAQQRIKELEERIEAQKRQIKE 824
L+ + LQ + R++ELE +EA++++ E
Sbjct: 1805 LKGGKKQLQKLEARVRELENELEAEQKRNAE 1835
Score = 92.0 bits (227), Expect = 2e-18
Identities = 177/874 (20%), Positives = 378/874 (43%), Gaps = 132/874 (15%)
Query: 10 AKGDKAEALAA-LQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVRE-HEQHK 67
A+ + +AL + LQ ++L+A++ +++ EL+ E++ +KVE+ ++ R++ E E+ +
Sbjct: 1092 ARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE 1151
Query: 68 TAVLLTELKTKLHEEKMKELQAVR---ETLLRQHEAELLRVIKIKDNENQRLQALLSALR 124
A T ++ ++++++ E Q +R E QHEA + K + L + L
Sbjct: 1152 EAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNL- 1210
Query: 125 DGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEE---ALTLVIQADKI 181
++VK L E+ K F++E + + ++ AK +E+ L + +
Sbjct: 1211 ----QRVKQKL-----EKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRS 1261
Query: 182 KAAEI-RSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQ 240
KA E RSV ++T + + + E L ++ K+ + L R + + Q+L+
Sbjct: 1262 KAEETQRSV-----NDLTSQRAKLQTENGELSRQLDEKEALISQLTRG---KLTYTQQLE 1313
Query: 241 LQKEALDEQ------LSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARR 294
K L+E+ L+ ++ RH RE + ++ ++ L + ++
Sbjct: 1314 DLKRQLEEEVKAKNALAHALQSARHDCDLLREQYE-----EETEAKAELQRVLSKANSEV 1368
Query: 295 FQLKIAELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPL------LDKNK-RLSRK 347
Q + + I++ E+ L E + +L +R++EAE + + L+K K RL +
Sbjct: 1369 AQWRTKYETDAIQRTEE----LEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE 1424
Query: 348 NEDLSHALRRMENKLKFV--TQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIV 405
EDL + R + Q N + + S ++L+ SQ +E L ++
Sbjct: 1425 IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ--KEARSLSTELF 1482
Query: 406 EQQNLIDELSKTLETAGYVKSVLER------DKLLRFRKQRKKMAKLPKPVVVETFFGYD 459
+ +N +E + LET L+ ++L K ++ K+ K + E +
Sbjct: 1483 KLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKM---E 1539
Query: 460 EEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALL 519
+++LE +S+ ++ + + LE K E E + + E + +R + +
Sbjct: 1540 LQSALEEAEASLEHEEGKILRA------QLEFNQIKAEIERKLAEKDEEMEQAKRNHLRV 1593
Query: 520 QEQVGGTLDAE-----REVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKWIE------ 568
+ + +LDAE ++ +++++ ++ + ++ + AE + +K ++
Sbjct: 1594 VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDT 1653
Query: 569 --EKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAIS 626
+ R N +L E I +E L+ E+++ R ++E ER RK
Sbjct: 1654 QIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR--------AVVEQTERSRK----- 1700
Query: 627 FHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDIL-GDNANLTNEEQVVVIQARTVLT 685
+ + + E +++ +L N +L N+++ + + T
Sbjct: 1701 ---------------------LAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQT 1739
Query: 686 LAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEA 745
E+ +Q+ E ++ + D E K++ L+ K+ ++Q I +L+
Sbjct: 1740 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQD-TSAHLERMKKNMEQT---IKDLQH 1795
Query: 746 MLYDALQ----------QEAGAKVAELLSEEEREKLKVAVE-QWKRQVMSELRERDAQIL 794
L +A Q Q+ A+V EL +E E E+ + A + R+ ++E Q
Sbjct: 1796 RLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTE 1855
Query: 795 RERMELLQLAQQRIKELEERIEAQKRQIKELEEK 828
+R LL+L Q + +L+ +++A KRQ +E EE+
Sbjct: 1856 EDRKNLLRL-QDLVDKLQLKVKAYKRQAEEAEEQ 1888
Score = 74.3 bits (181), Expect = 4e-13
Identities = 169/768 (22%), Positives = 312/768 (40%), Gaps = 176/768 (22%)
Query: 116 LQALLSALRDGGPEKVKTVLLSE-----AKEEAKKGFEVEK--VKMQQEISELKGAKRQV 168
L LL +RD ++ T + ++ A+ E KK E + +Q I G K
Sbjct: 769 LLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWP 828
Query: 169 EEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERE 228
L I+ +K+AE +EE TR+K+ E+ R E +++ V +L+ +
Sbjct: 829 WMKLYFKIKP-LLKSAEREKEMASMKEEFTRLKEALEKSEARRKE---LEEKMVSLLQEK 884
Query: 229 LGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLD 288
LQLQ +A + L+ E R + ++ A + + E+ D
Sbjct: 885 --------NDLQLQVQAEQDNLADAEE--RCDQLIKNKIQLEAKVKEMN------ERLED 928
Query: 289 EKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKN 348
E++ AEL+A RKLED + L + ++L + + E + +K K L+ +
Sbjct: 929 EEEMN------AELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEM 982
Query: 349 EDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQ 408
L + ++ + K + E Q+A L+DL +D +V+ L V+ +
Sbjct: 983 AGLDEIIAKLTKEKKALQ----EAHQQA--------LDDLQAEED--KVNTLTKAKVKLE 1028
Query: 409 NLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDG 468
+D+L +LE V+ LER K ++ + KL + +++ LE+D
Sbjct: 1029 QQVDDLEGSLEQEKKVRMDLERAK-----RKLEGDLKLTQESIMD----------LEND- 1072
Query: 469 SSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLD 528
L+E + K++ EL +E EQ G+
Sbjct: 1073 -----------------KQQLDERLKKKDFELNALNARIE-----------DEQALGS-- 1102
Query: 529 AEREVKTREQLQAEVQRAQARIEDLEKAL-AEQGQDMKWIEEKQALYRRNQELVEKI--- 584
QLQ +++ QARIE+LE+ L AE+ K + + L R +E+ E++
Sbjct: 1103 ---------QLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEA 1153
Query: 585 -----------KQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFV 633
K+ E E ++R ++++A Q+E + R++ + +++ +
Sbjct: 1154 GGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL-----RKKHADSVA-ELGEQI 1207
Query: 634 DGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQA------RTVLTLA 687
D ++ E E +E +LD + +N EQ++ +A RT+
Sbjct: 1208 DNLQRVKQKLEKE------KSEFKLELDDV-----TSNMEQIIKAKANLEKMCRTLEDQM 1256
Query: 688 EKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAML 747
+ + EET QR + DL S++ + G L +LD ++ + Q + L L
Sbjct: 1257 NEHRSKAEET----QRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQL 1312
Query: 748 YD---ALQQEAGAKVA------------ELLSEEEREKLKVAVE-------------QWK 779
D L++E AK A +LL E+ E+ + E QW+
Sbjct: 1313 EDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWR 1372
Query: 780 RQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEE 827
+ ++ +R ++ + +L QR++E EE +EA + LE+
Sbjct: 1373 TKYETDAIQRTEELEEAKKKL----AQRLQEAEEAVEAVNAKCSSLEK 1416
Score = 68.9 bits (167), Expect = 2e-11
Identities = 141/715 (19%), Positives = 292/715 (40%), Gaps = 132/715 (18%)
Query: 9 RAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKT 68
+AK + + L+ + R+K + Q + S+ +K++ E + RQ+ E E +
Sbjct: 1240 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALIS 1299
Query: 69 AVL---------LTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNE-NQRLQA 118
+ L +LK +L EE + +H+ +LLR ++ E LQ
Sbjct: 1300 QLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQR 1359
Query: 119 LLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQA 178
+LS SE + K +E + ++ +E+ E K Q + ++A
Sbjct: 1360 VLSKAN------------SEVAQWRTK-YETDAIQRTEELEEAKKKLAQRLQEAEEAVEA 1406
Query: 179 DKIKAAEIRSVYHLHQEEITRIKKECE-------------REIRRLMEEIKFK-DRAVFV 224
K + + H Q EI + + E R +++ E K K + +
Sbjct: 1407 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 1466
Query: 225 LERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPE 284
LE + L K A +E L + R + + E+ D ++ GS
Sbjct: 1467 LESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI------SDLTEQLGSSG 1520
Query: 285 QQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRL 344
+ + E + R QL+ AE + LE+ A L E ++L+ E +Q K ++ ++L
Sbjct: 1521 KTIHELEKVRKQLE-AEKMELQSALEEAEASLEHEEGKILRAQLEF-NQIKAEIE--RKL 1576
Query: 345 SRKNEDLSHALRRMENKLKFV----TQENIEMRQRAGIIR----RPSSLNDLD------- 389
+ K+E++ A R N L+ V T + E R R +R LN+++
Sbjct: 1577 AEKDEEMEQAKR---NHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN 1633
Query: 390 --QSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLER---------DKLLRFRK 438
++ +++V L+ + + Q +D+ + + +++ER ++L +
Sbjct: 1634 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1693
Query: 439 QRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGM----- 493
Q ++ KL + ++ET + L S +S+ Q + D ++EE +
Sbjct: 1694 QTERSRKLAEQELIET---SERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1750
Query: 494 AKEETELRFRQLTMEYQALQRA------YALLQEQVGGTL-DAEREVKTREQL-----QA 541
A+E+ + M + L++ +++ + T+ D + + EQ+ +
Sbjct: 1751 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1810
Query: 542 EVQRAQARIEDLEKAL-AEQGQDMKWI-----------------EEKQALYRRNQELVEK 583
++Q+ +AR+ +LE L AEQ ++ + + EE + R Q+LV+K
Sbjct: 1811 QLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDK 1870
Query: 584 IK------QMETEEA------------RLRHEVQDARDQNELLEFRILELEERER 620
++ + + EEA +++HE+ +A ++ ++ E ++ +L + R
Sbjct: 1871 LQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1925
Score = 62.8 bits (151), Expect = 1e-09
Identities = 83/421 (19%), Positives = 181/421 (42%), Gaps = 32/421 (7%)
Query: 11 KGDKAEALAALQAANEDLR---AKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHK 67
+ +K E +AL+ A L K+ Q+E Q K+++ + EK++E+ Q + +
Sbjct: 1534 EAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLR- 1592
Query: 68 TAVLLTELKTKLHEEKMKELQAVR-----ETLLRQHEAELLRVIKIKDNENQRLQALLSA 122
++ L+T L E +A+R E L + E +L ++ +++++L S
Sbjct: 1593 ---VVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSL 1649
Query: 123 LRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIK 182
L+D + V ++ +E E +Q E+ EL+ Q E + L Q + I+
Sbjct: 1650 LKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQ-ELIE 1708
Query: 183 AAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQ 242
+E + H + KK+ + ++ +L E+ + AV +E A++
Sbjct: 1709 TSERVQLLHSQNTSLINQKKKMDADLSQLQTEV---EEAV----QECRNAEEKAKKAITD 1761
Query: 243 KEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAEL 302
+ E+L + ++ H ++ + H +Q+ K ++ ++ +L
Sbjct: 1762 AAMMAEELKKEQDTSAHLERMKKNMEQTI---KDLQHRLDEAEQIALKGGKK---QLQKL 1815
Query: 303 SAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKL 362
A +R+LE+ + E +K +R++E + K L + + + L + +++ K+
Sbjct: 1816 EARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKV 1875
Query: 363 KFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQ-NLIDELSKTLETA 421
K ++ E ++A ++L+ + Q E + + I E Q N + S+ + T
Sbjct: 1876 KAYKRQAEEAEEQAN-----TNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTK 1930
Query: 422 G 422
G
Sbjct: 1931 G 1931
Score = 55.1 bits (131), Expect = 3e-07
Identities = 84/351 (23%), Positives = 164/351 (46%), Gaps = 43/351 (12%)
Query: 494 AKEETELRFRQLTMEYQALQRAYALLQEQVGGTLD--------AEREVKTREQLQAEVQR 545
A E++E R ++L + +L + LQ QV D ++ +K + QL+A+V+
Sbjct: 862 ALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKE 921
Query: 546 AQARIEDLEKALAEQGQDMKWIEEKQALYRRN-QELVEKIKQMETEEARLRHEVQDARDQ 604
R+ED E+ AE + +E++ + +R+ +L + ++E E+ ++V++ ++
Sbjct: 922 MNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEE 981
Query: 605 NELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILG 664
L+ I +L + ++ A+ H +D + E + V + A++ + +
Sbjct: 982 MAGLDEIIAKLTKEKK---ALQEAHQQALD-----DLQAEEDKVNTLTKAKVKLEQQVDD 1033
Query: 665 DNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDE 724
+L E++V R L A++ ++E Q ++DLE++K+ LDE
Sbjct: 1034 LEGSLEQEKKV-----RMDLERAKR---KLEGDLKLTQESIMDLENDKQ-------QLDE 1078
Query: 725 ELDYRKQALDQANKHILELEAMLYDALQ---QEAGAKVAELLSEEEREK-LKVAVEQWKR 780
L + L+ N I E E L LQ +E A++ EL E E E+ + VE+ +
Sbjct: 1079 RLKKKDFELNALNARI-EDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRS 1137
Query: 781 QVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQ-KRQIKELEEKFL 830
+ EL E + ER+E A E+ ++ EA+ ++ ++LEE L
Sbjct: 1138 DLSRELEE-----ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATL 1183
Score = 32.7 bits (73), Expect = 1.4
Identities = 36/158 (22%), Positives = 69/158 (43%), Gaps = 21/158 (13%)
Query: 672 EEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQ 731
E + + + T ++ L++ E L+ KMV L EK Q + L ++
Sbjct: 844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEE 903
Query: 732 ALDQANKHILELEAMLYDALQQEAGAKVAELLSE-EEREKLKVAVEQWKRQVMSELRERD 790
DQ K+ ++LE AKV E+ E+ E++ + KR++ E E
Sbjct: 904 RCDQLIKNKIQLE------------AKVKEMNERLEDEEEMNAELTAKKRKLEDECSE-- 949
Query: 791 AQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEK 828
L+ ++ L+L + ++E+ A + ++K L E+
Sbjct: 950 ---LKRDIDDLELT---LAKVEKEKHATENKVKNLTEE 981
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 108 bits (269), Expect = 3e-23
Identities = 181/834 (21%), Positives = 342/834 (41%), Gaps = 141/834 (16%)
Query: 52 EKNQELRQVREH-EQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKD 110
E +E+ ++E E+ K + TE K K EEKM L + L Q +AE + ++
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEE 907
Query: 111 NENQRLQALLSALRDGGPEKVKTVL-LSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVE 169
+Q ++ + K+K V +E +EE +K K++ E SEL K+ ++
Sbjct: 908 RCDQLIKTKIQL-----EAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL---KKDID 959
Query: 170 EALTLVIQADKIKAAEIRSVYHLHQE---------EITRIKKECEREIRRLMEEIKFKDR 220
+ + + +K K A V +L +E ++T+ KK + ++ +++++ ++
Sbjct: 960 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEED 1019
Query: 221 AVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELP-HAAGAGDASDH 279
V L + +L+ Q + L+ L Q ++ +R+L A +++
Sbjct: 1020 KVNTLTKA-------KTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMD 1072
Query: 280 SGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNAL---LSEERNELLKRVREAESQYKP 336
+ + +QQL+EK + K E+S + K+ED AL L ++ EL R+ E E + +
Sbjct: 1073 TENDKQQLNEK----LKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEA 1128
Query: 337 LLDKNKRLSRKNEDLSHALRRMENKLK---FVTQENIEMRQRAGIIRRPSSLNDLDQSQD 393
+ ++ DLS L + +L+ T IEM ++ DL++S
Sbjct: 1129 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE-AEFQKMRRDLEESTL 1187
Query: 394 EREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVE 453
+ E L+ + + + EL + +++ VK LE++ K KM
Sbjct: 1188 QHEATAAALR-KKHADSVAELGEQIDSLQRVKQKLEKE------KSELKM---------- 1230
Query: 454 TFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRF----------- 502
E L S+ +VS ++ T +D L E KEE + R
Sbjct: 1231 ------EINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARL 1284
Query: 503 --------RQL----TMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRA---- 546
RQL M Q + A Q+ E E K + L +Q A
Sbjct: 1285 HTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDC 1344
Query: 547 ---QARIEDLEKALAEQGQDMKWIEEKQALYRRNQE--LVEKIKQMETEEARLRHEVQDA 601
+ + E+ ++A AE + M + A +R E +++ +++E + +L +QDA
Sbjct: 1345 DLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDA 1404
Query: 602 RDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLD 661
+ E + + LE+ +++ + L + E I + + + D
Sbjct: 1405 EEHVEAVNSKCASLEKTKQR----------LQNEVEDLMIDVERSNAACIALDKKQRNFD 1454
Query: 662 ILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGY 721
LAE W Q+ EET+A L+ + S K K
Sbjct: 1455 ----------------------KVLAE-WKQKYEETQAELEASQKESRSLSTELFKVKNA 1491
Query: 722 LDEELDYRKQALDQANKHILELEAMLYDALQQ--EAGAKVAELLSEEEREKLKVAVEQWK 779
+E LD+ + L + NK+ L+ + D +Q E G + EL EK+K ++ K
Sbjct: 1492 YEESLDH-LETLKRENKN---LQQEISDLTEQIAEGGKHIHEL------EKVKKQLDHEK 1541
Query: 780 RQVMSELRERDAQILRERMELL--QLAQQRIK-ELEERIEAQKRQIKELEEKFL 830
++ + L E +A + E ++L QL ++K E++ +I + ++ +L+ L
Sbjct: 1542 SELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHL 1595
Score = 94.4 bits (233), Expect = 4e-19
Identities = 172/872 (19%), Positives = 362/872 (41%), Gaps = 126/872 (14%)
Query: 9 RAKGDKAEALAA-LQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVRE-HEQH 66
+ K + +ALA LQ ++L+A++ +++ E++ E++ +K E++++ R++ E E+
Sbjct: 1095 QGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL 1154
Query: 67 KTAVLLTELKTKLHEEKMKELQAVRETLLR---QHEAELLRVIKIKDNENQRLQALLSAL 123
+ A T + ++++++ E Q +R L QHEA + K + L + +L
Sbjct: 1155 EEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSL 1214
Query: 124 RDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKA 183
+ K+ E EK +++ EI++L V +A
Sbjct: 1215 -----------------QRVKQKLEKEKSELKMEINDLASNMETVSKA-----------K 1246
Query: 184 AEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFV----LERELGVQAGHAQRL 239
A + +++++ IK + E E +RL+ E+ + + R+L + +L
Sbjct: 1247 ANFEKMCRTLEDQLSEIKTK-EEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQL 1305
Query: 240 QLQKEALDEQLSQVREADRHPGSPRRELPHAAGAG----DASDHSGSPEQQLDEKDARRF 295
K+A +Q+ +++ + L HA + D EQ+ + R
Sbjct: 1306 SRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGM 1365
Query: 296 QLKIAELSAIIRKLE----DRNALLSEERNELLKRVREAESQYKPL------LDKNK-RL 344
+E++ K E R L E + +L +R+++AE + + L+K K RL
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRL 1425
Query: 345 SRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQI 404
+ EDL + R + ++ + ++ + ++E L ++
Sbjct: 1426 QNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTEL 1485
Query: 405 VEQQNLIDELSKTLETAGYVKSVLERD------KLLRFRKQRKKMAKLPKPVVVETFFGY 458
+ +N +E LET L+++ ++ K ++ K+ K + E
Sbjct: 1486 FKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKS--- 1542
Query: 459 DEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYAL 518
+ + SLE +S+ ++ + + LE K E + + + E L+R +
Sbjct: 1543 ELQTSLEEAEASLEHEEGKILRI------QLELNQVKSEIDRKIAEKDEELDQLKRNHLR 1596
Query: 519 LQEQVGGTLDAERE-----VKTREQLQAEVQRAQARIEDLEKALAEQGQDMK----WIEE 569
+ E + TLDAE ++ +++++ ++ + ++ + AE ++++ +++
Sbjct: 1597 VVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKD 1656
Query: 570 KQA----LYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLE----FRILELEERERK 621
Q R +L E++ +E ++ EV++ R E E EL + +
Sbjct: 1657 TQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASER 1716
Query: 622 SPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQAR 681
+ +T ++ K L+ TDI I G+ ++ E + +A+
Sbjct: 1717 VQLLHTQNTSLINTKKKLE--------TDIS--------QIQGEMEDIVQEARNAEEKAK 1760
Query: 682 TVLTLAEKWLQQI---EETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQ-ALDQAN 737
+T A +++ ++T A L+R ++E + L LD +Q AL
Sbjct: 1761 KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK-------DLQLRLDEAEQLALKGGK 1813
Query: 738 KHILELEAMLYDALQQEAGAKVAELLSEEERE-KLKVAVEQWKRQVMSELRERDAQILRE 796
K I +LEA +V EL SE E E K V + R+ ++E Q +
Sbjct: 1814 KQIQKLEA------------RVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEED 1861
Query: 797 RMELLQLAQQRIKELEERIEAQKRQIKELEEK 828
R +L+L Q + +L+ +++A KRQ +E EE+
Sbjct: 1862 RKNILRL-QDLVDKLQTKVKAYKRQAEEAEEQ 1892
Score = 92.0 bits (227), Expect = 2e-18
Identities = 194/926 (20%), Positives = 383/926 (41%), Gaps = 140/926 (15%)
Query: 13 DKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
D+ E A L A L + ++++ ++ + ++KVE+EK+ +V+ + L
Sbjct: 932 DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG--L 989
Query: 73 TELKTKLHEEKMKELQAVRETL--LRQHEAELLRVIKIKDNENQRLQALLSALRDGGP-- 128
E KL +EK +A ++TL L+ E ++ + K K Q++ L +L
Sbjct: 990 DETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLC 1049
Query: 129 ---EKVKTVLLSEAK--EEAKKGFEVEKVKMQQEIS----ELKGAKRQVEEALTLVIQAD 179
E+ K L + K +E+ E +K ++ +++ E+ + ++E+ L IQ
Sbjct: 1050 MDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQ 1109
Query: 180 KIKAAEIRSVYHLHQEEI-----TRIKKECER-EIRRLMEEIKFKDRAVFVLERELG--- 230
K K E+++ +EEI +R K E +R ++ R +EEI + LE G
Sbjct: 1110 K-KIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER------LEEAGGATS 1162
Query: 231 --VQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLD 288
++ + + QK D + S ++ ++ A G+ D +Q+L
Sbjct: 1163 AQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKL- 1221
Query: 289 EKDARRFQLKIAELSA--------------IIRKLEDRNALLSEERNELLKRVREAESQY 334
EK+ +++I +L++ + R LED+ + + + E + + E +Q
Sbjct: 1222 EKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQK 1281
Query: 335 KPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEM-RQRAGIIRRPSSLNDLDQSQD 393
L ++ SR+ ++ + ++ + TQ+ E+ RQ + S+L QS
Sbjct: 1282 ARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSA- 1340
Query: 394 EREVDFLKLQIVEQQNLIDEL----SKTLETAGYVKSVLERDKLLR---FRKQRKKMAKL 446
+ D L+ Q E+Q EL SK ++ E D + R + +KK+A+
Sbjct: 1341 RHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1400
Query: 447 PKPVVVETFFGYDEEASLESDGSSVSYQTD------RTDQTPCTPDDDLEEGMAK--EET 498
+ + ASLE + + + C D + K E
Sbjct: 1401 LQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEW 1460
Query: 499 ELRFRQLTMEYQALQRAYALLQEQVGGTLDA-EREVKTREQLQAEVQRAQARIEDLEKAL 557
+ ++ + E +A Q+ L ++ +A E + E L+ E + Q I DL + +
Sbjct: 1461 KQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQI 1520
Query: 558 AEQGQDMKWIEE-KQALYRRNQELVEKIKQMETEEARLRHEV-QDARDQNELLEFRI--- 612
AE G+ + +E+ K+ L EL +E EA L HE + R Q EL + +
Sbjct: 1521 AEGGKHIHELEKVKKQLDHEKSELQ---TSLEEAEASLEHEEGKILRIQLELNQVKSEID 1577
Query: 613 LELEERERKSPAISFHHTPFVDG------------KSPLQVYCEAEGVTDIV-------- 652
++ E++ + + +H V+ L++ + EG + +
Sbjct: 1578 RKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHAN 1637
Query: 653 --VAELMKKL----DILGDNANLTNE---------EQVVVIQARTVLTLAEKWLQQIEET 697
AE ++ L IL D ++ EQ+ +++ R L AE +EE
Sbjct: 1638 RQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAE-----VEEL 1692
Query: 698 EAALQR----------KMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAML 747
A+L+R +++D +L Q L ++ +K+ ++ E+E ++
Sbjct: 1693 RASLERTERGRKMAEQELLDASERVQLLHTQNTSL---INTKKKLETDISQIQGEMEDIV 1749
Query: 748 YDALQQEAGAK--------VAELLSEEE-----REKLKVAVEQWKRQVMSELRERDAQIL 794
+A E AK +AE L +E+ E++K +EQ + + L E + L
Sbjct: 1750 QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLAL 1809
Query: 795 RERMELLQLAQQRIKELEERIEAQKR 820
+ + +Q + R++ELE +E++++
Sbjct: 1810 KGGKKQIQKLEARVRELESEVESEQK 1835
Score = 55.8 bits (133), Expect = 2e-07
Identities = 73/380 (19%), Positives = 164/380 (43%), Gaps = 37/380 (9%)
Query: 11 KGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAV 70
K + +L +A+ E K+ IQ+EL Q KS++ + EK++EL Q++ +
Sbjct: 1541 KSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLR---- 1596
Query: 71 LLTELKTKLHEEKMKELQAVRETLLRQHEAELLRV-IKIKDNENQRLQALLSALRDGGPE 129
++ +++ L E A+R + ++ E +L + I++ Q +AL + G
Sbjct: 1597 VVESMQSTLDAEIRSRNDALR--IKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGIL 1654
Query: 130 KVKTVLLSEA---KEEAKKGFEVEKVK---MQQEISELKGAKRQVEEALTLVIQADKIKA 183
K + L +A +++ K+ + + + MQ E+ EL+ + + E + Q + + A
Sbjct: 1655 KDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQ-ELLDA 1713
Query: 184 AEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQK 243
+E + H + KK+ E +I ++ E++ + +E A++
Sbjct: 1714 SERVQLLHTQNTSLINTKKKLETDISQIQGEME-------DIVQEARNAEEKAKKAITDA 1766
Query: 244 EALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLK----- 298
+ E+L + ++ H ++ + + QL +A + LK
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNMEQTV-----------KDLQLRLDEAEQLALKGGKKQ 1815
Query: 299 IAELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRM 358
I +L A +R+LE + E +K +R+ E + K L + + + L + ++
Sbjct: 1816 IQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKL 1875
Query: 359 ENKLKFVTQENIEMRQRAGI 378
+ K+K ++ E +++ +
Sbjct: 1876 QTKVKAYKRQAEEAEEQSNV 1895
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 107 bits (266), Expect = 6e-23
Identities = 198/887 (22%), Positives = 385/887 (43%), Gaps = 145/887 (16%)
Query: 45 KVSKVERE---KNQELRQVREHEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAE 101
+VS+ E E K +EL +VRE +Q LTE++T L + M E ++E L Q E E
Sbjct: 839 QVSRQEEEMMAKEEELVKVRE-KQLAAENRLTEMET-LQSQLMAEKLQLQEQL--QAETE 894
Query: 102 LLRVIKIKDNENQRLQALLSALRDGGPEKVKTVLLS-EAKEEAKKGFEVEKVKMQQEISE 160
L E + L+A L+A + E + E +EE + + EK KMQQ I E
Sbjct: 895 LCA-------EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQE 947
Query: 161 LKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDR 220
L+ + + EE+ +Q +K+ + L +E+I + C +L +E K +
Sbjct: 948 LE-EQLEEEESARQKLQLEKVTTE--AKLKKLEEEQIILEDQNC-----KLAKEKKLLED 999
Query: 221 AVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAAG--AGDASD 278
+ L + ++ L K + ++ + E R R+EL GD++D
Sbjct: 1000 RIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTD 1059
Query: 279 HSGSPEQQLDEKDARRFQLKI------AELSAIIRKLEDRNALLSEERNELLKRVREAES 332
S Q+ E A+ +LK+ EL A + ++E+ A ++N LK++RE ES
Sbjct: 1060 LS----DQIAELQAQIAELKMQLAKKEEELQAALARVEEEAA----QKNMALKKIRELES 1111
Query: 333 QYKPLLD--KNKRLSR-----KNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSL 385
Q L + +++R SR + DL L ++ +L+ ++ +R +
Sbjct: 1112 QISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRS--KREQEV 1169
Query: 386 NDLDQS-QDEREVDFLKLQIVEQQN--LIDELSKTLETAGYVKSVLERDKLLRFRKQRKK 442
N L ++ ++E + ++Q + Q++ ++EL++ LE VK+ LE+ K +R +
Sbjct: 1170 NILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAK-QTLENERGE 1228
Query: 443 MAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAK------- 495
+A K ++ + +E+ + + + ++ D + + +
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGL 1288
Query: 496 -EETELRFRQLTMEYQA----LQRAYALLQEQVGGTLDAEREVKT--------REQLQAE 542
+++ + +LT ++ A LQ LLQE+ L ++K REQL+ E
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEE 1348
Query: 543 ----------VQRAQARIEDLEKALAEQGQDMKWIEE--------KQALYRRNQELVEKI 584
+ A++ D++K + + ++ EE + L +R++E V
Sbjct: 1349 EEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAY 1408
Query: 585 KQMETEEARLRHEVQD------------------ARDQNELL------------EFRILE 614
++E + RL+ E+ D + ++LL E E
Sbjct: 1409 DKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAE 1468
Query: 615 LEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTD---IVVAELMKKLDILGDNAN-LT 670
E RE+++ A+S + ++ E E + + +LM D +G + + L
Sbjct: 1469 AEAREKETKALSLARAL----EEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELE 1524
Query: 671 NEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRK 730
++ + Q + T E+ +++ TE A R V+L++ K F + DE+ + +K
Sbjct: 1525 KSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKK 1584
Query: 731 QALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKR---QVMSELR 787
+ Q + + E+EA L D +Q + A A E + + L+ ++ + + + +LR
Sbjct: 1585 K---QLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR 1641
Query: 788 ERDAQI---LRE-------RMELLQLAQQRIKELEERIEAQKRQIKE 824
+ AQ+ +RE R E+L A++ K+L+ +EA+ Q++E
Sbjct: 1642 KLQAQMKDCMRELDDTRASREEILAQAKENEKKLKS-MEAEMIQLQE 1687
Score = 97.8 bits (242), Expect = 4e-20
Identities = 187/921 (20%), Positives = 372/921 (40%), Gaps = 164/921 (17%)
Query: 13 DKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
D ++ +A LQA +L+ +L + ELQ ++V + +KN L+++RE E +
Sbjct: 1059 DLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQ-----I 1113
Query: 73 TELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVK 132
+EL+ L E+ +A ++ ++ E L +K + + A LR ++V
Sbjct: 1114 SELQEDLESERASRNKAEKQ---KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVN 1170
Query: 133 TVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHL 192
+L + EE K E + +M+Q+ S+ VEE + Q ++KA ++ L
Sbjct: 1171 --ILKKTLEEEAKTHEAQIQEMRQKHSQ------AVEELAEQLEQTKRVKANLEKAKQTL 1222
Query: 193 HQEEITRIKKECEREIRRLME---EIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQ 249
E + E E++ L++ + + K + V +EL V+ +R++ + L ++
Sbjct: 1223 ENE-----RGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTE---LADK 1274
Query: 250 LSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKL 309
+++++ EL + G L + D++ +L + SA+ +L
Sbjct: 1275 VTKLQV----------ELDNVTGL-------------LSQSDSKSSKL-TKDFSALESQL 1310
Query: 310 EDRNALLSEERNE------LLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLK 363
+D LL EE + LK+V + ++ ++ L++ + E L +K
Sbjct: 1311 QDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMK 1370
Query: 364 FVTQENIEMRQRAGIIRR--PSSLNDLDQSQDEREVDFLKLQIVEQ--QNLIDELSKTLE 419
++++ + A ++R L L Q +E+ + KL+ + Q +D+L L+
Sbjct: 1371 KKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLD 1430
Query: 420 TAGYVKSVLER-----DKLL-------------RFRKQRKKMAKLPKPVVVETFFGYDEE 461
LE+ D+LL R R + + K K + + E
Sbjct: 1431 HQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAME 1490
Query: 462 ASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQE 521
E + + ++T+ D + DD+ G + E E R L + + ++ L++
Sbjct: 1491 QKAELERLNKQFRTEMEDL--MSSKDDV--GKSVHELEKSKRALEQQVEEMKTQLEELED 1546
Query: 522 QVGGTLDA---------------EREVKTRE--------QLQAEVQRAQARIEDLEK--- 555
++ T DA ER+++ R+ QL +V+ +A +ED K
Sbjct: 1547 ELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRS 1606
Query: 556 ----ALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFR 611
A + D+K +E +N++ E IKQ+ +A+++ +++ D E
Sbjct: 1607 MAVAARKKLEMDLKDLEAHIDSANKNRD--EAIKQLRKLQAQMKDCMRELDDTRASREEI 1664
Query: 612 ILELEERERK-----SPAISFHHTPFVDGKSPLQVYCEAEGVTDIV-------------- 652
+ + +E E+K + I ++ Q E + + D +
Sbjct: 1665 LAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEK 1724
Query: 653 ------VAELMKKLDILGDNANLTNEE----QVVVIQARTVLTLAEKWLQQIEETEAALQ 702
+A+L ++L+ N L N+ + + Q T L L Q+ E L+
Sbjct: 1725 RRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLE 1784
Query: 703 RKMVDL-----ESEKELFSKQK----------GYLDEELDYRKQALDQANKHILELEAML 747
R+ +L E E + SK K L+E+LD + A K + E L
Sbjct: 1785 RQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKL 1844
Query: 748 YDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQR 807
D L Q + +++ +K ++Q KRQ + E E + R +L Q+
Sbjct: 1845 KDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQ-LEEAEEEAQRANASRRKL----QRE 1899
Query: 808 IKELEERIEAQKRQIKELEEK 828
+++ E +A R++ L+ K
Sbjct: 1900 LEDATETADAMNREVSSLKNK 1920
Score = 94.7 bits (234), Expect = 3e-19
Identities = 205/973 (21%), Positives = 406/973 (41%), Gaps = 223/973 (22%)
Query: 13 DKAEALAALQAANEDLRAKLT-----------DIQIELQQEKSKVSKVEREKN------Q 55
++ +A L A E+LRA+LT D++ +++E+ + ++ EK Q
Sbjct: 887 EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946
Query: 56 EL-RQVREHEQHKTAVLLTELKTKLHEEKMKELQAVRE----TLLRQHEAELLRVIKIKD 110
EL Q+ E E + + L ++ T+ +K++E Q + E L ++ + R+ +
Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006
Query: 111 N--ENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVK--------------- 153
N E + L+ L++ E + T L + E K+ E+EK +
Sbjct: 1007 NLTEEEEKSKSLAKLKN-KHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIA 1065
Query: 154 -MQQEISELKGAKRQVEEALTLVIQADKIKAA----------EIRSVYHLHQEEI---TR 199
+Q +I+ELK + EE L + + +AA E+ S QE++
Sbjct: 1066 ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERA 1125
Query: 200 IKKECEREIRRLMEEIKF---------------------KDRAVFVLERELGVQA-GHAQ 237
+ + E++ R L EE++ +++ V +L++ L +A H
Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA 1185
Query: 238 RLQLQK-------EALDEQLSQVR-------EADRHPGSPRRELPHAA-----GAGDASD 278
++Q + E L EQL Q + +A + + R EL + G GD+
Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEH 1245
Query: 279 HSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLL 338
E QL E Q+K E + +L D+ L E + + + +++S+ L
Sbjct: 1246 KRKKVEAQLQE-----LQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLT 1300
Query: 339 DKNKRLSRKNEDLSHALRR-------MENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQS 391
L + +D L+ + KLK V E R++ L + +++
Sbjct: 1301 KDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQ---------LEEEEEA 1351
Query: 392 QD--EREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKP 449
+ E+++ L Q+ + + +++ LETA VK L++D ++ +K+A K
Sbjct: 1352 KHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKL 1411
Query: 450 VVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEY 509
+T L+ + + D Q+ C E+ + +F QL E
Sbjct: 1412 EKTKT--------RLQQELDDLLVDLDHQRQSACN----------LEKKQKKFDQLLAEE 1453
Query: 510 QAL--------QRAYALLQEQVGGTLDAEREVKTREQLQAEVQRA----QARIEDLEKAL 557
+ + RA A +E+ L R ++ + +AE++R + +EDL +
Sbjct: 1454 KTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSK 1513
Query: 558 AEQGQDMKWIEE-KQALYRRNQELVEKIKQME-----TEEARLRHEV------------- 598
+ G+ + +E+ K+AL ++ +E+ +++++E TE+A+LR EV
Sbjct: 1514 DDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDL 1573
Query: 599 ----QDARDQNELLEFRILELE-----ERERKSPAISFHHTPFVDGKSPLQVYCEAEGVT 649
+ + ++ + L ++ E+E ER+++S A++ +D
Sbjct: 1574 QGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMD--------------- 1618
Query: 650 DIVVAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDL- 708
+K L+ D+AN +E + Q R + + ++++++T A+ + +
Sbjct: 1619 -------LKDLEAHIDSANKNRDE--AIKQLRKLQAQMKDCMRELDDTRASREEILAQAK 1669
Query: 709 ESEKELFSKQKG--YLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEE 766
E+EK+L S + L EEL ++A QA + EL D + +G L+ E
Sbjct: 1670 ENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELA----DEIANSSGKGA---LALE 1722
Query: 767 EREKLKVAVEQWKRQVMSELRERDAQILRERMEL--LQLAQQRIKELEERIEAQK----- 819
E+ +L+ + Q + ++ E + + +++ +R++ LQ+ Q ER AQK
Sbjct: 1723 EKRRLEARIAQLEEELEEE--QGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENAR 1780
Query: 820 ----RQIKELEEK 828
RQ KEL+ K
Sbjct: 1781 QQLERQNKELKVK 1793
Score = 76.6 bits (187), Expect = 9e-14
Identities = 95/438 (21%), Positives = 195/438 (44%), Gaps = 66/438 (15%)
Query: 1 MSKRGMSSRAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKS---------KVSKVER 51
MS + ++ + ++ AL+ E+++ +L +++ ELQ + + K +
Sbjct: 1510 MSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQF 1569
Query: 52 EKNQELRQVREHEQHKTAVL-LTELKTKLHEEKMKELQAVR-----ETLLRQHEAELLRV 105
E++ + R + E+ K V + E++ +L +E+ + AV E L+ EA +
Sbjct: 1570 ERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSA 1629
Query: 106 IKIKDNENQRLQALLSALRDGGPEKVKT-----VLLSEAKEEAKK--GFEVEKVKMQQEI 158
K +D ++L+ L + ++D E T +L++AKE KK E E +++Q+E+
Sbjct: 1630 NKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEEL 1689
Query: 159 SELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEE-----ITRIKKECERE---IRR 210
+ + AKRQ ++ + AD+I + + L ++ I ++++E E E
Sbjct: 1690 AAAERAKRQAQQERDEL--ADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTEL 1747
Query: 211 LMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHA 270
+ + +K + + + +L ++ HAQ+ + ++ L+ Q +++
Sbjct: 1748 INDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVK-------------- 1793
Query: 271 AGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREA 330
Q+++ +++ I L A I +LE++ ++ER K+VR
Sbjct: 1794 -------------LQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRT 1840
Query: 331 ESQYKPLL---DKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRR--PSSL 385
E + K +L D +R + + +D + +LK +E E QRA RR L
Sbjct: 1841 EKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Query: 386 NDLDQSQD--EREVDFLK 401
D ++ D REV LK
Sbjct: 1901 EDATETADAMNREVSSLK 1918
Score = 33.9 bits (76), Expect = 0.65
Identities = 71/337 (21%), Positives = 142/337 (42%), Gaps = 64/337 (18%)
Query: 495 KEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLE 554
+EE +L+ + + +QA R Y L + K ++QL A ++ L+
Sbjct: 772 EEERDLKITDVIIGFQACCRGY----------LARKAFAKRQQQLTA--------MKVLQ 813
Query: 555 KALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILE 614
+ A + W + L+ + + L++ +Q E A+ E+ R++ E R+ E
Sbjct: 814 RNCAAYLKLRNW--QWWRLFTKVKPLLQVSRQEEEMMAK-EEELVKVREKQLAAENRLTE 870
Query: 615 LEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGD-NANLTNEE 673
+E + + A + ++ L EAE + + A+ + +I D A + EE
Sbjct: 871 METLQSQLMAEKLQLQEQLQAETEL--CAEAEELRARLTAKKQELEEICHDLEARVEEEE 928
Query: 674 ---QVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRK 730
Q + + + + ++ +Q+EE E+A Q+ L+ EK + L+EE +
Sbjct: 929 ERCQHLQAEKKKMQQNIQELEEQLEEEESARQK----LQLEKVTTEAKLKKLEEE----Q 980
Query: 731 QALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERD 790
L+ N + + + +L D + A+ L+EEE + +A + K + M
Sbjct: 981 IILEDQNCKLAKEKKLLEDRI-----AEFTTNLTEEEEKSKSLAKLKNKHEAM------- 1028
Query: 791 AQILRERMELLQLAQQRIKELEERIEAQKRQIKELEE 827
I +LEER+ +++Q +ELE+
Sbjct: 1029 -----------------ITDLEERLRREEKQRQELEK 1048
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 107 bits (266), Expect = 6e-23
Identities = 183/870 (21%), Positives = 373/870 (42%), Gaps = 101/870 (11%)
Query: 18 LAALQAANEDLRAKLTDIQI---ELQQEKSKVSKVEREKNQELR---QVREHE--QHKTA 69
L L+ N+ L + +++ ++ SK+ K+E+E NQ L ++ E+E Q K +
Sbjct: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKE-NQRLSKKVEILENEIVQEKQS 520
Query: 70 VLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGP- 128
+ + +K ++ +L+ ETL E R IKI + EN+ L +S+LR
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSE----RQIKILEQENEHLNQTVSSLRQRSQI 576
Query: 129 ---------EKVKTVLLSEAKEEAKK--GFEVEKVKMQQEISELKGAKRQVEEALTLVIQ 177
EK +L KE + K E EK ++++E+ K + EE +
Sbjct: 577 SAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHH 636
Query: 178 ADKIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQ 237
+K L Q++IT +K CE+ I L +E +R R+L +
Sbjct: 637 LEKEN--------ELLQKKITNLKITCEK-IEALEQENSELERE----NRKLKKTLDSFK 683
Query: 238 RLQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLD-EKDARRFQ 296
L Q E+L+++ SQ+ E + RR + A ++L+ EK+ +
Sbjct: 684 NLTFQLESLEKENSQLDEENLEL---RRNVESLKCASMKMAQLQLENKELESEKEQLKKG 740
Query: 297 LKIAE--------LSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKN 348
L++ + L + L+ N L + K++++ ES+ + L +N+ L +
Sbjct: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL 800
Query: 349 EDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQ 408
E+L + +R+E + +EN + Q + + + + + ++ + + E
Sbjct: 801 EELKISSKRLEQ----LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENN 856
Query: 409 NLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDG 468
I L K +T + ++ +R ++ K+ +L K ++ +L D
Sbjct: 857 VKIGNLEKENKTLSKEIGIY-KESCVRLKELEKENKELVKRATIDI----KTLVTLREDL 911
Query: 469 SSVSYQTDRTDQTPCTPDDDLEE-GMAKEE-------TELRFRQLTMEYQALQRAYALLQ 520
S +T + + +LE+ G+ KE T+ R++ L + ++ + ++
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIK 971
Query: 521 EQVGGTLDAEREVKTR--EQLQAEVQRAQARIEDLEKALAEQ----------GQDMKWIE 568
E+ L+A E T +QL+ E++ + E L++ E+ G+D KW
Sbjct: 972 EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWER 1031
Query: 569 EKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEER----ERKSPA 624
E Q R ++ +++ ++E A L+ E Q + Q + LE + L+ + +R++ +
Sbjct: 1032 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS 1091
Query: 625 ISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQARTVL 684
+ +T + LQV E + + + + +L ++L NE + V+ + +
Sbjct: 1092 LQEQNTTLQTQNAKLQV--ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLK 1149
Query: 685 TLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYL---DEELDYRKQALDQANKHIL 741
+L + ++ E+ E +R+ + ES L SK G L + L+ + L+ +L
Sbjct: 1150 SLYDSLIKDHEKLELLHERQASEYES---LISKH-GTLKSAHKNLEVEHRDLEDRYNQLL 1205
Query: 742 ELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELL 801
+ + L D L++ + ++L E + + A + L +Q+L+E E+L
Sbjct: 1206 KQKGQLED-LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE-TEVL 1263
Query: 802 QLAQQRIKEL-------EERIEAQKRQIKE 824
Q + +K L + R+EA+ ++KE
Sbjct: 1264 QTDHKNLKSLLNNSKLEQTRLEAEFSKLKE 1293
Score = 99.4 bits (246), Expect = 1e-20
Identities = 179/869 (20%), Positives = 347/869 (39%), Gaps = 114/869 (13%)
Query: 8 SRAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHK 67
+RA+ DK L L+ N L+AKL D+++E ++ K+ ++ E+N L ++ +
Sbjct: 370 TRARSDK---LHELEKENLQLKAKLHDMEMERDMDRKKIEEL-MEENMTLEMAQKQSMDE 425
Query: 68 TAVLLTELKTKLHEEKMKELQAVRETLLRQ-HEAELLRVIKIKDNENQRLQALLSALR-- 124
+ L EL+ ++ E A +++L + +E R++K+ + ENQ L + LR
Sbjct: 426 SLHLGWELEQISRTSELSE--APQKSLGHEVNELTSSRLLKL-EMENQSLTKTVEELRTT 482
Query: 125 ----DGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADK 180
+G K+ + + + + K E+ + ++ QE L+ + ++ + Q +K
Sbjct: 483 VDSVEGNASKI--LKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 181 IKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQ 240
I +++ ER+I+ L +E + ++ V L + + A A+
Sbjct: 541 T---------------IETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA-EARVKD 584
Query: 241 LQKE------ALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARR 294
++KE ++ E S++ + + ++EL H G+ ++ + L EK+
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHL-EKENEL 643
Query: 295 FQLKIAELSAIIRK---LEDRNALLSEERNELLKRVREAES---QYKPLLDKNKRLSRKN 348
Q KI L K LE N+ L E +L K + ++ Q + L +N +L +N
Sbjct: 644 LQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEEN 703
Query: 349 EDLSH---ALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDER-EVDFLKLQI 404
+L +L+ K+ + EN E+ +++ L + ER EV + L I
Sbjct: 704 LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI 763
Query: 405 VEQQNLIDELSKTLETAGYVKSVLERD---------KLLRFRKQRKKMAKLPKPVVVETF 455
Q+ L KTLE + LE + L + ++ K +K + + E
Sbjct: 764 ENQR-----LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818
Query: 456 FGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEE-----GMAKEETELRFRQLTMEYQ 510
E + LE D + + R Q D LEE G ++E + +++ + +
Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878
Query: 511 ALQRAYALLQEQVG----GTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKW 566
+ R L +E T+D + V RE L +E + Q DLEK
Sbjct: 879 SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK----------- 927
Query: 567 IEEKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAIS 626
L +++++ + RL H+ Q D+ +LLE + LE +KS I
Sbjct: 928 -------------LTHELEKIGLNKERLLHDEQSTDDRYKLLESK---LESTLKKSLEIK 971
Query: 627 FHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQARTVLTL 686
+ L+ E + + + +K + + +E+ +V + +
Sbjct: 972 EEKI------AALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1025
Query: 687 AEKWLQQIEETEAALQR---KMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILEL 743
KW ++ +ET L + +++++E +K L +L + + IL L
Sbjct: 1026 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL 1085
Query: 744 EAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQ------VMSELRERDAQILRER 797
+ +Q + + E L Q S L + +++ER
Sbjct: 1086 QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKER 1145
Query: 798 MELLQLAQQRIKELEERIEAQKRQIKELE 826
+L L IK+ E+ +RQ E E
Sbjct: 1146 EDLKSLYDSLIKDHEKLELLHERQASEYE 1174
Score = 76.3 bits (186), Expect = 1e-13
Identities = 162/851 (19%), Positives = 353/851 (41%), Gaps = 133/851 (15%)
Query: 14 KAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLT 73
+ E+ L D +AK+ ++ EL+++ ++ + QEL Q+
Sbjct: 242 RTESRQHLSVELADAKAKIRRLRQELEEKTEQL----LDCKQELEQME-----------I 286
Query: 74 ELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVKT 133
ELK +L +E M L R + + E + LR ++ ++
Sbjct: 287 ELK-RLQQENMNLLSDARSARMYRDELDALREKAVRVDK--------------------- 324
Query: 134 VLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRS--VYH 191
L SE ++ ++E K + + ELK + + E T++ D+++ RS ++
Sbjct: 325 -LESEVSRYKERLHDIEFYKAR--VEELKEDNQVLLETKTML--EDQLEGTRARSDKLHE 379
Query: 192 LHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDE--- 248
L +E + K + E+ R M+ K ++ ++E + ++ QK+++DE
Sbjct: 380 LEKENLQLKAKLHDMEMERDMDRKKIEE----LMEENMTLE-------MAQKQSMDESLH 428
Query: 249 ---QLSQVREADRHPGSPRRELPHAAGAGDASD-HSGSPEQQLDEKDARRFQLKIAEL-- 302
+L Q+ +P++ L H +S E Q K + + +
Sbjct: 429 LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG 488
Query: 303 -SAIIRKLEDRNALLSEE----RNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRR 357
++ I K+E N LS++ NE+++ + ++ D K ++ + +
Sbjct: 489 NASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN 548
Query: 358 MENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQD-EREVDFLKLQIVEQQNLIDELSK 416
E ++K + QEN + Q +R+ S ++ + +D E+E L I E + +LSK
Sbjct: 549 SERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSS---KLSK 605
Query: 417 TLETAGYVKSVLE--RDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQ 474
+K LE ++K R + ++ L K E L+ +++
Sbjct: 606 IEFEKRQIKKELEHYKEKGERAEELENELHHLEK-----------ENELLQKKITNLKIT 654
Query: 475 TDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVK 534
++ + + E ++T F+ LT + ++L++ + L E+ L+ R V+
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE---NLELRRNVE 711
Query: 535 TREQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARL 594
+ + ++ + Q ++LE +E+ Q K +E +A +++ + L + ++ E RL
Sbjct: 712 SLKCASMKMAQLQLENKELE---SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRL 768
Query: 595 RHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVA 654
+ ++++ + + LE + +LE + LQ E ++ +
Sbjct: 769 QKTLENSNKKIQQLESELQDLEMENQ-----------------TLQKNLEELKISSKRLE 811
Query: 655 ELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQR---KMVDLESE 711
+L K +N +L E + + + ++ QQ E + L+ K+ +LE E
Sbjct: 812 QLEK------ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Query: 712 KELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEER--- 768
+ SK+ G E R + L++ NK +++ + L V+E L ++
Sbjct: 866 NKTLSKEIGIYKESC-VRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNND 924
Query: 769 -EKLKVAVEQW---KRQVMSELRERD--AQILRERME-----LLQLAQQRIKELEERIEA 817
EKL +E+ K +++ + + D ++L ++E L++ +++I LE R+E
Sbjct: 925 LEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEE 984
Query: 818 QKRQIKELEEK 828
++L ++
Sbjct: 985 STNYNQQLRQE 995
Score = 74.3 bits (181), Expect = 4e-13
Identities = 168/846 (19%), Positives = 345/846 (40%), Gaps = 156/846 (18%)
Query: 71 LLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEK 130
++ ++ KL +++ + + + LR H +L V +IK + LQ L+
Sbjct: 51 VMLQINPKLESQRVNK-KVNNDASLRMHNLSIL-VRQIKFYYQETLQQLIMMSLPNVLII 108
Query: 131 VKTVLLSEAKEEAKK------GFEVEKVKMQQEISELKGAKRQVEEALTLVIQA-----D 179
K + EE KK G V+ K ++ I ++G + A+ IQ +
Sbjct: 109 GKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQE 168
Query: 180 KIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRL 239
+ + V + QE+I + K ++RL++E + L E
Sbjct: 169 NVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERD--------- 219
Query: 240 QLQKEALDEQLSQVREADRHPGSPRRELPH--AAGAGDASDHSGSPEQQLDEKDARRFQL 297
L S + PG R E + DA Q+L+EK +
Sbjct: 220 --GLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDC 277
Query: 298 K--IAELSAIIRKLEDRNA-LLSEERNELLKR-----VREAESQYKPLLDKNKRLSRKNE 349
K + ++ +++L+ N LLS+ R+ + R +RE + L + R +
Sbjct: 278 KQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLH 337
Query: 350 DLSHALRRMENKLKFVTQENIEMR-----QRAGIIRRPSSLNDLDQS-----------QD 393
D+ R+E +LK Q +E + Q G R L++L++ +
Sbjct: 338 DIEFYKARVE-ELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEM 396
Query: 394 EREVDFLKLQIVEQQNL-------------------IDELSKTLETA-------GYVKSV 427
ER++D K++ + ++N+ ++++S+T E + G+ +
Sbjct: 397 ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNE 456
Query: 428 LERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDD 487
L +LL+ + + + K V E D S+E + S + + ++ +Q +
Sbjct: 457 LTSSRLLKLEMENQSLTK----TVEELRTTVD---SVEGNASKI-LKMEKENQRLSKKVE 508
Query: 488 DLEEGMAKEETELR-----FRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAE 542
LE + +E+ L+ + L E L++ L+E ++ER++K EQ
Sbjct: 509 ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE------NSERQIKILEQENEH 562
Query: 543 VQR------------AQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETE 590
+ + A+AR++D+EK E + L+ +E K+ ++E E
Sbjct: 563 LNQTVSSLRQRSQISAEARVKDIEK-------------ENKILHESIKETSSKLSKIEFE 609
Query: 591 EARLRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTD 650
+ +++ E++ +++ E E EL E+++ + T L++ CE +
Sbjct: 610 KRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN-------LKITCEKIEALE 662
Query: 651 IVVAEL----MKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMV 706
+EL K L NLT + L EK Q++E L+R +
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQ-----------LESLEKENSQLDEENLELRRNVE 711
Query: 707 DLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEE 766
L+ + Q ++EL+ K+ L + LEL L + ++ +V+ +
Sbjct: 712 SLKCASMKMA-QLQLENKELESEKEQLKKG----LEL---LKASFKKTERLEVSYQGLDI 763
Query: 767 EREKLKVAVEQWKRQVM---SELR--ERDAQILRERMELLQLAQQRIKELEERIEAQKRQ 821
E ++L+ +E +++ SEL+ E + Q L++ +E L+++ +R+++LE+ ++ +++
Sbjct: 764 ENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQE 823
Query: 822 IKELEE 827
+LE+
Sbjct: 824 TSQLEK 829
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 106 bits (265), Expect = 8e-23
Identities = 190/931 (20%), Positives = 382/931 (41%), Gaps = 142/931 (15%)
Query: 13 DKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
D+ E A L A L + ++++ ++ + ++KVE+EK+ +V+ + L
Sbjct: 930 DEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG--L 987
Query: 73 TELKTKLHEEKMKELQAVRETL--LRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEK 130
E+ KL +EK +A ++ L L+ E ++ + K K Q++ L +G E+
Sbjct: 988 DEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDL-----EGSLEQ 1042
Query: 131 VKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEAL----------TLVIQADK 180
K V + E AK+ E + Q+ I +L+ K Q+EE L I+ ++
Sbjct: 1043 EKKVRMD--LERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQ 1100
Query: 181 IKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLER--ELGVQAGHAQR 238
+ A +++ +Q I +++E E E + K + LE E +AG A
Sbjct: 1101 VLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATS 1160
Query: 239 LQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLD---------E 289
+Q++ E Q D + + E AA +D +Q+D E
Sbjct: 1161 VQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE 1220
Query: 290 KDARRFQLKIAELSAIIRK-------LEDRNALLSEERNELLKRVREAESQYKPLLDKNK 342
K+ F+L++ ++++ + + LE + L ++ NE ++ EA+ +
Sbjct: 1221 KEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRA 1280
Query: 343 RLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRP--------SSLNDLDQSQDE 394
+L +N +L+ L E + +T+ + Q+ ++R ++L QS
Sbjct: 1281 KLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSA-R 1339
Query: 395 REVDFLKLQIVEQQNLIDELSKTLETAGYV----KSVLERDKLLRFRKQRKKMAKLPKPV 450
+ D L+ Q E+ EL + L A ++ E D + R + + KL + +
Sbjct: 1340 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1399
Query: 451 --VVETFFGYDEEAS--------LESDGSSVSYQTDRTDQTPCTPD-------------- 486
E + + S L+++ + +R++ D
Sbjct: 1400 QDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWK 1459
Query: 487 DDLEEGMAK-EETELRFRQLTMEYQALQRAY---------------------ALLQEQVG 524
EE ++ E ++ R L+ E L+ AY + L EQ+G
Sbjct: 1460 QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1519
Query: 525 -GTLDAEREVKTREQLQAEVQRAQARIEDLEKALA-EQGQ----DMKWIEEKQALYRRNQ 578
G + K R+QL+ E Q+ +E+ E +L E+G+ +++ + K + R+
Sbjct: 1520 EGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA 1579
Query: 579 ELVEKIKQMETEEARLRHEVQ-----DARDQNELLEFRILELEERERKSPAISFHHTPFV 633
E E+++Q + R+ +Q + R +NE+L R+ + E + I H +
Sbjct: 1580 EKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVL--RVKKKMEGDLNEMEIQLSHANRM 1637
Query: 634 DGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNE---EQVVVIQARTVLTLAE-- 688
++ QV + L+K I D+A N+ E + +++ R L AE
Sbjct: 1638 AAEAQKQVKS---------LQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELE 1688
Query: 689 ---KWLQQIEETEAALQRKMVD-------LESEKELFSKQKGYLDEELDYRKQALDQANK 738
++Q E + ++++++ L S+ QK ++ +L + +++A +
Sbjct: 1689 ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQ 1748
Query: 739 HILELEAMLYDALQQEAGAKVAELLSEEER-----EKLKVAVEQWKRQVMSELRERDAQI 793
E A+ A +AE L +E+ E++K +EQ + + L E +
Sbjct: 1749 ECRNAEEKAKKAITD--AAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIA 1806
Query: 794 LRERMELLQLAQQRIKELEERIEAQKRQIKE 824
L+ + LQ + R++ELE +EA++++ E
Sbjct: 1807 LKGGKKQLQKLEARVRELEGELEAEQKRNAE 1837
Score = 78.6 bits (192), Expect = 2e-14
Identities = 159/777 (20%), Positives = 320/777 (41%), Gaps = 92/777 (11%)
Query: 81 EEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVKTVLLSEA- 139
E + KEL+ +LL++ L+V +DN N + +++ + K ++E
Sbjct: 869 EARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERL 928
Query: 140 --KEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQE-- 195
+EE +K K++ E SEL K+ +++ + + +K K A V +L +E
Sbjct: 929 EDEEEMNAELTAKKRKLEDECSEL---KKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 985
Query: 196 -------EITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDE 248
++T+ KK + ++ +++++ ++ V L + +L+ Q + L+
Sbjct: 986 GLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKS-------KVKLEQQVDDLEG 1038
Query: 249 QLSQVREADRHPGSPRRELPHAAGAGDASDHS-GSPEQQLDEKDARRFQLKIAELSAIIR 307
L Q ++ +R+L S + + QL+EK + K +++
Sbjct: 1039 SLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEK----LKKKEFDINQQNS 1094
Query: 308 KLEDRNAL---LSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLK- 363
K+ED L L ++ E R+ E E + + ++ + DLS L + +L+
Sbjct: 1095 KIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEE 1154
Query: 364 --FVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETA 421
T IEM ++ DL+++ + E L+ + + + EL + ++
Sbjct: 1155 AGGATSVQIEMNKKRE-AEFQKMRRDLEEATLQHEATAAALR-KKHADSVAELGEQIDNL 1212
Query: 422 GYVKSVLERDKL--------LRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSY 473
VK LE++K + ++ AK V T E ++ + + S
Sbjct: 1213 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSL 1272
Query: 474 QTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREV 533
D T Q ++ E EE E QLT + + L+ Q+ E E
Sbjct: 1273 -NDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQL------EEEG 1325
Query: 534 KTREQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEAR 593
K + L +Q A+ + L + E+ + E ++ L + N E+ + + ET+ +
Sbjct: 1326 KAKNALAHALQSARHDCDLLREQYEEETEAK--AELQRVLSKANSEVAQWRTKYETDAIQ 1383
Query: 594 LRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVV 653
E+++A+ + L++ E A++ + K LQ + D++V
Sbjct: 1384 RTEELEEAKKK------LAQRLQDAEEAVEAVNAKCSSLEKTKHRLQ-----NEIEDLMV 1432
Query: 654 AELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKE 713
D+ NA ++ + R + +W Q+ EE+++ L+ + S
Sbjct: 1433 -------DVERSNAAAAALDK----KQRNFDKILAEWKQKYEESQSELESSQKEARSLST 1481
Query: 714 LFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKV 773
K K +E L++ + + NK++ E + L + L E G V EL EK++
Sbjct: 1482 ELFKLKNAYEESLEH-LETFKRENKNLQEEISDLTEQL-GEGGKNVHEL------EKVRK 1533
Query: 774 AVEQWKRQVMSELRERDA-------QILRERMELLQL---AQQRIKELEERIEAQKR 820
+E K ++ S L E +A +ILR ++E Q+ ++++ E +E +E KR
Sbjct: 1534 QLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKR 1590
Score = 70.5 bits (171), Expect = 6e-12
Identities = 158/739 (21%), Positives = 318/739 (43%), Gaps = 118/739 (15%)
Query: 116 LQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVK--------MQQEISELKGAKRQ 167
L LL +RD ++ T + ++A+ + + E +K+ +Q I G K
Sbjct: 771 LLGLLEEMRDERLSRIITRMQAQARGQLMR-IEFKKIVERRDALLVIQWNIRAFMGVKNW 829
Query: 168 VEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLER 227
L I+ +K+AE +EE RIK+ E+ R E +++ V +L+
Sbjct: 830 PWMKLYFKIKP-LLKSAETEKEMATMKEEFGRIKETLEKSEARRKE---LEEKMVSLLQE 885
Query: 228 ELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQL 287
+ LQLQ +A + L+ E R + ++ A + + E+
Sbjct: 886 K--------NDLQLQVQAEQDNLNDAEE--RCDQLIKNKIQLEAKVKEMN------ERLE 929
Query: 288 DEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRK 347
DE++ AEL+A RKLED + L ++ ++L + + E + +K K L+ +
Sbjct: 930 DEEEMN------AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 983
Query: 348 NEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQ 407
L + ++ + K + E Q+A L+DL +D +V+ L V+
Sbjct: 984 MAGLDEIIAKLTKEKKALQ----EAHQQA--------LDDLQVEED--KVNSLSKSKVKL 1029
Query: 408 QNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESD 467
+ +D+L +LE V+ LER K ++ + KL + +++ LE+D
Sbjct: 1030 EQQVDDLEGSLEQEKKVRMDLERAK-----RKLEGDLKLTQESIMD----------LEND 1074
Query: 468 GSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTL 527
+ + + + D+ + +K E E + L ++ Q + E++ L
Sbjct: 1075 KLQLEEKLKK-------KEFDINQQNSKIEDE---QVLALQLQKKLKENQARIEELEEEL 1124
Query: 528 DAEREVKTR-EQLQAEVQRAQARI-EDLEKALAEQGQDMKWIEEKQALYRR-NQELVEKI 584
+AER + + E+L++++ R I E LE+A ++ ++++A +++ ++L E
Sbjct: 1125 EAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEAT 1184
Query: 585 KQMETEEARLRHE----VQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQ 640
Q E A LR + V + +Q + L+ R+ + E+E+ + D S ++
Sbjct: 1185 LQHEATAAALRKKHADSVAELGEQIDNLQ-RVKQKLEKEKSEFKLELD-----DVTSNME 1238
Query: 641 VYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAA 700
+A+ A L K L D A NE +V + +A+ L +++
Sbjct: 1239 QIIKAK-------ANLEKVSRTLEDQA---NEYRVKLEEAQRSLNDFTTQRAKLQTENGE 1288
Query: 701 LQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANK------HILELEAMLYDALQQ- 753
L R++ + E+ ++ K ++++ K+ L++ K H L+ D L++
Sbjct: 1289 LARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQ 1348
Query: 754 -----EAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRI 808
EA A++ +LS+ E V QW+ + ++ +R ++ + +L QR+
Sbjct: 1349 YEEETEAKAELQRVLSKANSE-----VAQWRTKYETDAIQRTEELEEAKKKL----AQRL 1399
Query: 809 KELEERIEAQKRQIKELEE 827
++ EE +EA + LE+
Sbjct: 1400 QDAEEAVEAVNAKCSSLEK 1418
Score = 64.7 bits (156), Expect = 3e-10
Identities = 76/392 (19%), Positives = 173/392 (44%), Gaps = 22/392 (5%)
Query: 13 DKAEALAALQAANEDLR---AKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTA 69
+K E +AL+ A L K+ Q+E Q K+++ + EK++E+ Q + + Q
Sbjct: 1538 EKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVD 1597
Query: 70 VLLTEL--KTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGG 127
L T L +T+ E ++ ++ E L + E +L ++ +++++L S L+D
Sbjct: 1598 SLQTSLDAETRSRNEVLR-VKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ 1656
Query: 128 PEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIR 187
+ V ++ +E E +Q E+ EL+ Q E + L Q + I+ +E
Sbjct: 1657 IQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQ-ELIETSERV 1715
Query: 188 SVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALD 247
+ H + KK+ E ++ +L E+ + AV +E A++ +
Sbjct: 1716 QLLHSQNTSLINQKKKMESDLTQLQSEV---EEAV----QECRNAEEKAKKAITDAAMMA 1768
Query: 248 EQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIR 307
E+L + ++ H ++ + H +Q+ K ++ ++ +L A +R
Sbjct: 1769 EELKKEQDTSAHLERMKKNMEQTI---KDLQHRLDEAEQIALKGGKK---QLQKLEARVR 1822
Query: 308 KLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQ 367
+LE + E +K +R++E + K L + + + L + +++ K+K +
Sbjct: 1823 ELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKR 1882
Query: 368 ENIEMRQRA--GIIRRPSSLNDLDQSQDEREV 397
+ E ++A + + ++LD++++ ++
Sbjct: 1883 QAEEAEEQANTNLSKFRKVQHELDEAEERADI 1914
Score = 33.5 bits (75), Expect = 0.85
Identities = 34/139 (24%), Positives = 64/139 (46%), Gaps = 21/139 (15%)
Query: 691 LQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDA 750
L++ E L+ KMV L EK Q + L+ ++ DQ K+ ++LE
Sbjct: 865 LEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLE------ 918
Query: 751 LQQEAGAKVAELLSE-EEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIK 809
AKV E+ E+ E++ + KR++ E E L++ ++ L+L +
Sbjct: 919 ------AKVKEMNERLEDEEEMNAELTAKKRKLEDECSE-----LKKDIDDLELT---LA 964
Query: 810 ELEERIEAQKRQIKELEEK 828
++E+ A + ++K L E+
Sbjct: 965 KVEKEKHATENKVKNLTEE 983
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 105 bits (263), Expect = 1e-22
Identities = 187/831 (22%), Positives = 346/831 (41%), Gaps = 148/831 (17%)
Query: 52 EKNQELRQVREHEQH-KTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKD 110
E +E+ ++E Q K + +E K K EEKM L + L Q +AE + ++
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 111 NENQRLQALLSALRDGGPEKVKTVL-LSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVE 169
+Q ++ + K+K V +E +EE +K K++ E SEL K+ ++
Sbjct: 910 RCDQLIKTKIQL-----EAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL---KKDID 961
Query: 170 EALTLVIQADKIKAAEIRSVYHLHQE---------EITRIKKECEREIRRLMEEIKFKDR 220
+ + + +K K A V +L +E ++T+ KK + ++ +++++ ++
Sbjct: 962 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1021
Query: 221 AVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELP-HAAGAGDASDH 279
V L + +L+ Q + L+ L Q ++ +R+L A ++
Sbjct: 1022 KVNTLTKA-------KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMD 1074
Query: 280 SGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNAL---LSEERNELLKRVREAESQYKP 336
+ +QQLDEK + K E+S + K+ED AL L ++ EL R+ E E + +
Sbjct: 1075 IENEKQQLDEK----LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130
Query: 337 LLDKNKRLSRKNEDLSHALRRMENKLK---FVTQENIEMRQR------------------ 375
+ ++ DLS L + +L+ T IEM ++
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1190
Query: 376 ----AGIIRR--PSSLNDLDQSQD--EREVDFLKLQIVEQQNLIDELSKTLETAGYVKSV 427
A +R+ S+ +L + D +R L+ + E + ID+L+ +ET K
Sbjct: 1191 HEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGN 1250
Query: 428 LER------DKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQT 481
LE+ D+L + + ++ +L + + L+++ S Q D
Sbjct: 1251 LEKMCRTLEDQLSELKSKEEEQQRLINDLTA-------QRGRLQTESGEFSRQLD----- 1298
Query: 482 PCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQA 541
E E QL+ QA + L+ Q+ E E+K + L
Sbjct: 1299 ---------------EKEALVSQLSRGKQAFTQQIEELKRQL------EEEIKAKNALAH 1337
Query: 542 EVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQDA 601
+Q ++ DL + E+ Q+ K E ++AL + N E+ + + ET+ + E+++A
Sbjct: 1338 ALQSSRHDC-DLLREQYEEEQESK-AELQRALSKANTEVAQWRTKYETDAIQRTEELEEA 1395
Query: 602 RDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLD 661
+ + L+ E A++ K LQ V D++ LD
Sbjct: 1396 KKK------LAQRLQAAEEHVEAVNAKCASLEKTKQRLQ-----NEVEDLM-------LD 1437
Query: 662 ILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGY 721
+ NA ++ + R + +W Q+ EET A L+ + S K K
Sbjct: 1438 VERTNAACAALDK----KQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNA 1493
Query: 722 LDEELDYRKQALDQANKHILELEAMLYDALQQ--EAGAKVAELLSEEEREKLKVAVEQWK 779
+E LD + + L + NK+ L+ + D +Q E G ++ EL EK+K VEQ K
Sbjct: 1494 YEESLD-QLETLKRENKN---LQQEISDLTEQIAEGGKRIHEL------EKIKKQVEQEK 1543
Query: 780 RQVMSELRERDA-------QILRERMELLQL---AQQRIKELEERIEAQKR 820
++ + L E +A +ILR ++EL Q+ ++I E +E I+ KR
Sbjct: 1544 CELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR 1594
Score = 96.3 bits (238), Expect = 1e-19
Identities = 197/932 (21%), Positives = 392/932 (42%), Gaps = 144/932 (15%)
Query: 13 DKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
D+ E A L A L + ++++ ++ + ++KVE+EK+ +V+ + L
Sbjct: 934 DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG--L 991
Query: 73 TELKTKLHEEKMKELQAVRETL--LRQHEAELLRVIKIKDNENQRLQALLSALRDGGP-- 128
E KL +EK +A ++TL L+ E ++ + K K Q++ L +L
Sbjct: 992 DETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLR 1051
Query: 129 ---EKVKTVLLSEAK--EEAKKGFEVEKVKMQQEIS----ELKGAKRQVEEALTLVIQAD 179
E+ K L + K +E+ E EK ++ +++ E+ + ++E+ L IQ
Sbjct: 1052 MDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQ 1111
Query: 180 KIKAAEIRSVYHLHQEEI-----TRIKKECER-EIRRLMEEIKFKDRAVFVLERELG--- 230
K K E+++ +EEI +R K E +R ++ R +EEI + LE G
Sbjct: 1112 K-KIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER------LEEAGGATS 1164
Query: 231 --VQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLD 288
++ + + QK D + + ++ ++ A G+ D+ +Q+L
Sbjct: 1165 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKL- 1223
Query: 289 EKDARRFQLKIAELSA--------------IIRKLEDRNALLSEERNELLKRVREAESQY 334
EK+ +++I +L++ + R LED+ + L + E + + + +Q
Sbjct: 1224 EKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQR 1283
Query: 335 KPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEM-RQRAGIIRRPSSLNDLDQSQD 393
L ++ SR+ ++ + ++ + TQ+ E+ RQ I+ ++L QS
Sbjct: 1284 GRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQS-S 1342
Query: 394 EREVDFLKLQIVEQQNLIDELSKTLETAG---------YVKSVLERDKLLRFRK----QR 440
+ D L+ Q E+Q EL + L A Y ++R + L K QR
Sbjct: 1343 RHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1402
Query: 441 KKMAKLPKPVVVETFFGYDE-EASLESDGSSVSYQTDRTDQTPCTPDD------------ 487
+ A+ V ++ + L+++ + +RT+ D
Sbjct: 1403 LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEW 1462
Query: 488 ---------DLEEGM---------------AKEETELRFRQLTMEYQALQRAYALLQEQV 523
+LE A EE+ + L E + LQ+ + L EQ+
Sbjct: 1463 KQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQI 1522
Query: 524 --GGTLDAEREVKTREQLQAEVQRAQARIEDLEKALA-EQGQ----DMKWIEEKQALYRR 576
GG E E K ++Q++ E QA +E+ E +L E+G+ ++ + K + R+
Sbjct: 1523 AEGGKRIHELE-KIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK 1581
Query: 577 NQELVEKIKQMETEEARLRHEVQ---DARDQNELLEFRILELEERERKSPAISFHHTPFV 633
E E+I Q++ R+ +Q DA ++ R+ + E + I +H +
Sbjct: 1582 IAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRM 1641
Query: 634 DGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNE---EQVVVIQARTVLTLAE-- 688
++ L+ Y +G+ +K I D+A + E EQ+ +++ R L AE
Sbjct: 1642 AAEA-LRNYRNTQGI--------LKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIE 1692
Query: 689 ---KWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEA 745
L+Q E + +++++D +L Q L ++ +K+ ++ E+E
Sbjct: 1693 ELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSL---INTKKKLETDISQMQGEMED 1749
Query: 746 MLYDALQQEAGAK--------VAELLSEEE-----REKLKVAVEQWKRQVMSELRERDAQ 792
+L +A E AK +AE L +E+ E++K +EQ + + L E +
Sbjct: 1750 ILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQL 1809
Query: 793 ILRERMELLQLAQQRIKELEERIEAQKRQIKE 824
L+ + +Q + R++ELE +E+++++ E
Sbjct: 1810 ALKGGKKQIQKLEARVRELEGEVESEQKRNAE 1841
Score = 91.7 bits (226), Expect = 3e-18
Identities = 177/868 (20%), Positives = 372/868 (42%), Gaps = 143/868 (16%)
Query: 21 LQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVRE-HEQHKTAVLLTELKTKL 79
LQ ++L+A++ +++ E++ E++ +K E++++ R++ E E+ + A T + ++
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1169
Query: 80 HEEKMKELQAVRETLLR---QHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVKTVLL 136
++++ E Q +R L QHEA + K + L + L
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNL------------- 1216
Query: 137 SEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEE 196
+ K+ E EK +M+ EI +L V +A + + +++
Sbjct: 1217 ----QRVKQKLEKEKSEMKMEIDDLASNVETVSKA-----------KGNLEKMCRTLEDQ 1261
Query: 197 ITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREA 256
++ +K + E E +RL+ ++ + L ++G R +KEAL QLS+ ++A
Sbjct: 1262 LSELKSK-EEEQQRLINDLTAQ-------RGRLQTESGEFSRQLDEKEALVSQLSRGKQA 1313
Query: 257 -DRHPGSPRRELPHAAGAGDASDHSGSPE--------QQLDEKDARRFQLKIA------E 301
+ +R+L A +A H+ +Q +E+ + +L+ A E
Sbjct: 1314 FTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTE 1373
Query: 302 LSAIIRKLE----DRNALLSEERNELLKRVREAESQYKPL------LDKNK-RLSRKNED 350
++ K E R L E + +L +R++ AE + + L+K K RL + ED
Sbjct: 1374 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVED 1433
Query: 351 LSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNL 410
L + R + ++ + ++ + ++E L ++ + +N
Sbjct: 1434 LMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNA 1493
Query: 411 IDELSKTLETAGYVKSVLERD------KLLRFRKQRKKMAKLPKPVVVETFFGYDEEASL 464
+E LET L+++ ++ K+ ++ K+ K V E + +A+L
Sbjct: 1494 YEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC---ELQAAL 1550
Query: 465 ESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVG 524
E +S+ ++ + + LE K E + + + E L+R + + E +
Sbjct: 1551 EEAEASLEHEEGKILRI------QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604
Query: 525 GTLDAERE-----VKTREQLQAEVQRAQARIEDLEKALAEQGQDMK---------WIEEK 570
TLDAE ++ +++++ ++ + ++ + AE ++ + I
Sbjct: 1605 STLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLD 1664
Query: 571 QALYRRNQELVEKIKQMETEEARLRHEVQDAR---DQNE----LLEFRILELEERERKSP 623
AL R ++L E++ +E L+ E+++ R +Q E + E +L+ ER +
Sbjct: 1665 DAL-RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ--- 1720
Query: 624 AISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKL-DILGDNANLTNEEQVVVIQART 682
+ +T ++ K L+ TDI +++ ++ DIL + N + + + A
Sbjct: 1721 LLHTQNTSLINTKKKLE--------TDI--SQMQGEMEDILQEARNAEEKAKKAITDAAM 1770
Query: 683 VLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQ-ALDQANKHIL 741
+AE+ L++ ++T A L+R ++E + L LD +Q AL K I
Sbjct: 1771 ---MAEE-LKKEQDTSAHLERMKKNMEQTVK-------DLQLRLDEAEQLALKGGKKQIQ 1819
Query: 742 ELEAMLYDALQQEAGAKVAELLSEEEREKLKVA-VEQWKRQVMSELRERDAQILRERMEL 800
+LEA +V EL E E E+ + A + R+ ++E Q +R +
Sbjct: 1820 KLEA------------RVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNI 1867
Query: 801 LQLAQQRIKELEERIEAQKRQIKELEEK 828
L+L Q + +L+ ++++ KRQ +E EE+
Sbjct: 1868 LRL-QDLVDKLQAKVKSYKRQAEEAEEQ 1894
Score = 78.6 bits (192), Expect = 2e-14
Identities = 168/853 (19%), Positives = 340/853 (39%), Gaps = 135/853 (15%)
Query: 9 RAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKT 68
+ + D EA +A LR K D EL ++ + +V+++ +E +++
Sbjct: 1179 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1238
Query: 69 AVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGP 128
+ + T K K + EKM + + L+ E E R+I + RLQ
Sbjct: 1239 SNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLD 1298
Query: 129 EKVKTV-LLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIR 187
EK V LS K+ + E K ++++EI + + AL +Q+ + +R
Sbjct: 1299 EKEALVSQLSRGKQAFTQQIEELKRQLEEEI--------KAKNALAHALQSSRHDCDLLR 1350
Query: 188 SVYHLHQEEITRIKKECEREIRRLMEEI-----KFKDRAVFVLERELGVQAGHAQRLQLQ 242
Y QE K E +R + + E+ K++ A+ E + AQRLQ
Sbjct: 1351 EQYEEEQES----KAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAA 1406
Query: 243 K---EALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKI 299
+ EA++ + + + + + + +L +A+ + +Q+ +K ++ K
Sbjct: 1407 EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKC 1466
Query: 300 AELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSH------ 353
E A + + L E ++ E+ Q + L +NK L ++ DL+
Sbjct: 1467 EETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGG 1526
Query: 354 -ALRRMENKLKFVTQENIEMRQRAGIIRRPSSLN---------DLDQSQDEREVDFLKLQ 403
+ +E K V QE E+ +A + +SL L+ +Q + EVD +
Sbjct: 1527 KRIHELEKIKKQVEQEKCEL--QAALEEAEASLEHEEGKILRIQLELNQVKSEVD---RK 1581
Query: 404 IVEQQNLIDELSKT-LETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEA 462
I E+ ID+L + + ++S L+ + +R R ++ K
Sbjct: 1582 IAEKDEEIDQLKRNHIRIVESMQSTLDAE--IRSRNDAIRLKK----------------- 1622
Query: 463 SLESDGSSVSYQTDRTDQTPCTPDDDLE--EGMAKEETELRFRQLTMEYQALQRAYALLQ 520
+E D + + Q + ++ + +G+ K +T++ + L+ A+++
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK-DTQIHLDDALRSQEDLKEQLAMVE 1681
Query: 521 EQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKA--LAEQGQDMKWIEEKQALYRRNQ 578
+ LQAE++ +A +E E++ +AEQ + + E Q L+ +N
Sbjct: 1682 RRA-------------NLLQAEIEELRATLEQTERSRKIAEQ-ELLDASERVQLLHTQNT 1727
Query: 579 ELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSP 638
L+ K++ET+ ++++ E++D L E R EE+ +K+
Sbjct: 1728 SLINTKKKLETDISQMQGEMEDI-----LQEAR--NAEEKAKKA---------------- 1764
Query: 639 LQVYCEAEGVTD--IVVAELMKKLDILGDNANL-TNEEQVVVIQARTVLTLAEKWLQQIE 695
+TD ++ EL K+ D + N EQ T+ + L+ E
Sbjct: 1765 ---------ITDAAMMAEELKKEQDTSAHLERMKKNMEQ----------TVKDLQLRLDE 1805
Query: 696 ETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEA 755
+ AL+ ++ + + +G ++ E +A+ KH ++ + Y +
Sbjct: 1806 AEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRK 1865
Query: 756 GAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERI 815
L ++ +KL+ V+ +KRQ + + + + R Q ++E EER
Sbjct: 1866 NI----LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRK-----LQHELEEAEERA 1916
Query: 816 EAQKRQIKELEEK 828
+ + Q+ +L K
Sbjct: 1917 DIAESQVNKLRVK 1929
Score = 68.6 bits (166), Expect = 2e-11
Identities = 148/669 (22%), Positives = 283/669 (42%), Gaps = 114/669 (17%)
Query: 181 IKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQ 240
+K+AE +EE +IK E + E K K+ LE ++ LQ
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKS------EAKRKE-----LEEKMVTLLKEKNDLQ 894
Query: 241 LQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIA 300
LQ +A E L+ E R + ++ A + + E+ DE++ A
Sbjct: 895 LQVQAEAEGLADAEE--RCDQLIKTKIQLEAKIKEVT------ERAEDEEEIN------A 940
Query: 301 ELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMEN 360
EL+A RKLED + L ++ ++L + + E + +K K L+ + L + ++
Sbjct: 941 ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK 1000
Query: 361 KLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLET 420
+ K + + + +L+DL +D +V+ L ++ + +D+L +LE
Sbjct: 1001 EKKALQEAH------------QQTLDDLQAEED--KVNTLTKAKIKLEQQVDDLEGSLEQ 1046
Query: 421 AGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQ 480
++ LER K ++ + KL + +++ + + + D+
Sbjct: 1047 EKKLRMDLERAK-----RKLEGDLKLAQESIMD-----------------IENEKQQLDE 1084
Query: 481 TPCTPDDDLEEGMAKEETELRFR-QLTMEYQALQRAYALLQEQVGGTLDAER-----EVK 534
+ ++ +K E E QL + + LQ L+E++ +AER K
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI----EAERASRAKAEK 1140
Query: 535 TREQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARL 594
R L E++ R+E+ A + Q + K E + RR +L E Q E A L
Sbjct: 1141 QRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR--DLEEATLQHEATAATL 1198
Query: 595 RHE----VQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTD 650
R + V + +Q + L+ R+ + E+E+ + D S ++ +A+G +
Sbjct: 1199 RKKHADSVAELGEQIDNLQ-RVKQKLEKEKSEMKMEID-----DLASNVETVSKAKGNLE 1252
Query: 651 IVVAELMKKLDILGDNANLTNEEQVVVI-----QARTVLTLAEKWLQQIEETEAALQRKM 705
+ L +L L EEQ +I Q + T + ++ +Q++E EA + +
Sbjct: 1253 KMCRTLEDQLSELKSK----EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ-- 1306
Query: 706 VDLESEKELFSKQ----KGYLDEELDYRKQALD---QANKHILELEAMLYDALQQEAGAK 758
L K+ F++Q K L+EE+ K AL Q+++H +L Y+ +QE+ A+
Sbjct: 1307 --LSRGKQAFTQQIEELKRQLEEEIK-AKNALAHALQSSRHDCDLLREQYEE-EQESKAE 1362
Query: 759 VAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQ 818
+ LS+ E V QW+ + ++ +R ++ + +L QR++ EE +EA
Sbjct: 1363 LQRALSKANTE-----VAQWRTKYETDAIQRTEELEEAKKKL----AQRLQAAEEHVEAV 1413
Query: 819 KRQIKELEE 827
+ LE+
Sbjct: 1414 NAKCASLEK 1422
Score = 59.3 bits (142), Expect = 1e-08
Identities = 80/409 (19%), Positives = 177/409 (43%), Gaps = 42/409 (10%)
Query: 6 MSSRAKGDKAEALAALQAANEDLR---AKLTDIQIELQQEKSKVSKVEREKNQELRQVRE 62
+ + + +K E AAL+ A L K+ IQ+EL Q KS+V + EK++E+ Q++
Sbjct: 1535 IKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR 1594
Query: 63 HEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRV-IKIKDNENQRLQALLS 121
+ ++ +++ L E A+R L ++ E +L + I++ +AL +
Sbjct: 1595 NHIR----IVESMQSTLDAEIRSRNDAIR--LKKKMEGDLNEMEIQLNHANRMAAEALRN 1648
Query: 122 ALRDGGPEKVKTVLLSEA---KEEAKKGFEVEKVK---MQQEISELKGAKRQVEEALTLV 175
G K + L +A +E+ K+ + + + +Q EI EL+ Q E + +
Sbjct: 1649 YRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1708
Query: 176 IQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGH 235
Q + + A+E + H + KK+ E +I ++ E++ +L+ +
Sbjct: 1709 EQ-ELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEME------DILQEARNAEE-K 1760
Query: 236 AQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRF 295
A++ + E+L + ++ H ++ + + QL +A +
Sbjct: 1761 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTV-----------KDLQLRLDEAEQL 1809
Query: 296 QLK-----IAELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNED 350
LK I +L A +R+LE + E +K +R+ E + K L + + +
Sbjct: 1810 ALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILR 1869
Query: 351 LSHALRRMENKLKFVTQ--ENIEMRQRAGIIRRPSSLNDLDQSQDEREV 397
L + +++ K+K + E E + + + ++L+++++ ++
Sbjct: 1870 LQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADI 1918
Score = 49.7 bits (117), Expect = 1e-05
Identities = 69/305 (22%), Positives = 142/305 (46%), Gaps = 27/305 (8%)
Query: 538 QLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHE 597
+ + E+ + + ++ LA+ K +EEK + + ++ Q E E E
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 598 VQDARDQNEL-LEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEA--EGVTDI--V 652
D + ++ LE +I E+ ER I+ T K L+ C + + D+
Sbjct: 910 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTA---KKRKLEDECSELKKDIDDLELT 966
Query: 653 VAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEK 712
+A++ K+ + EE + + LT +K LQ+ A Q+ + DL++E+
Sbjct: 967 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE------AHQQTLDDLQAEE 1020
Query: 713 E---LFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVA-ELLSEEER 768
+ +K K L++++D + +L+Q K ++LE + E K+A E + + E
Sbjct: 1021 DKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERA---KRKLEGDLKLAQESIMDIEN 1077
Query: 769 EKLKVAVEQWKRQ-----VMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIK 823
EK ++ + K++ + S++ + A ++ + ++ +L Q RI+ELEE IEA++
Sbjct: 1078 EKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKEL-QARIEELEEEIEAERASRA 1136
Query: 824 ELEEK 828
+ E++
Sbjct: 1137 KAEKQ 1141
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 105 bits (263), Expect = 1e-22
Identities = 187/831 (22%), Positives = 346/831 (41%), Gaps = 148/831 (17%)
Query: 52 EKNQELRQVREHEQH-KTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKD 110
E +E+ ++E Q K + +E K K EEKM L + L Q +AE + ++
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 111 NENQRLQALLSALRDGGPEKVKTVL-LSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVE 169
+Q ++ + K+K V +E +EE +K K++ E SEL K+ ++
Sbjct: 910 RCDQLIKTKIQL-----EAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL---KKDID 961
Query: 170 EALTLVIQADKIKAAEIRSVYHLHQE---------EITRIKKECEREIRRLMEEIKFKDR 220
+ + + +K K A V +L +E ++T+ KK + ++ +++++ ++
Sbjct: 962 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1021
Query: 221 AVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELP-HAAGAGDASDH 279
V L + +L+ Q + L+ L Q ++ +R+L A ++
Sbjct: 1022 KVNTLTKA-------KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMD 1074
Query: 280 SGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNAL---LSEERNELLKRVREAESQYKP 336
+ +QQLDEK + K E+S + K+ED AL L ++ EL R+ E E + +
Sbjct: 1075 IENEKQQLDEK----LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130
Query: 337 LLDKNKRLSRKNEDLSHALRRMENKLK---FVTQENIEMRQR------------------ 375
+ ++ DLS L + +L+ T IEM ++
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1190
Query: 376 ----AGIIRR--PSSLNDLDQSQD--EREVDFLKLQIVEQQNLIDELSKTLETAGYVKSV 427
A +R+ S+ +L + D +R L+ + E + ID+L+ +ET K
Sbjct: 1191 HEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGN 1250
Query: 428 LER------DKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQT 481
LE+ D+L + + ++ +L + + L+++ S Q D
Sbjct: 1251 LEKMCRTLEDQLSELKSKEEEQQRLINDLTA-------QRGRLQTESGEFSRQLD----- 1298
Query: 482 PCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQA 541
E E QL+ QA + L+ Q+ E E+K + L
Sbjct: 1299 ---------------EKEALVSQLSRGKQAFTQQIEELKRQL------EEEIKAKNALAH 1337
Query: 542 EVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQDA 601
+Q ++ DL + E+ Q+ K E ++AL + N E+ + + ET+ + E+++A
Sbjct: 1338 ALQSSRHDC-DLLREQYEEEQESK-AELQRALSKANTEVAQWRTKYETDAIQRTEELEEA 1395
Query: 602 RDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLD 661
+ + L+ E A++ K LQ V D++ LD
Sbjct: 1396 KKK------LAQRLQAAEEHVEAVNAKCASLEKTKQRLQ-----NEVEDLM-------LD 1437
Query: 662 ILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGY 721
+ NA ++ + R + +W Q+ EET A L+ + S K K
Sbjct: 1438 VERTNAACAALDK----KQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNA 1493
Query: 722 LDEELDYRKQALDQANKHILELEAMLYDALQQ--EAGAKVAELLSEEEREKLKVAVEQWK 779
+E LD + + L + NK+ L+ + D +Q E G ++ EL EK+K VEQ K
Sbjct: 1494 YEESLD-QLETLKRENKN---LQQEISDLTEQIAEGGKRIHEL------EKIKKQVEQEK 1543
Query: 780 RQVMSELRERDA-------QILRERMELLQL---AQQRIKELEERIEAQKR 820
++ + L E +A +ILR ++EL Q+ ++I E +E I+ KR
Sbjct: 1544 CELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR 1594
Score = 96.3 bits (238), Expect = 1e-19
Identities = 197/932 (21%), Positives = 392/932 (42%), Gaps = 144/932 (15%)
Query: 13 DKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
D+ E A L A L + ++++ ++ + ++KVE+EK+ +V+ + L
Sbjct: 934 DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG--L 991
Query: 73 TELKTKLHEEKMKELQAVRETL--LRQHEAELLRVIKIKDNENQRLQALLSALRDGGP-- 128
E KL +EK +A ++TL L+ E ++ + K K Q++ L +L
Sbjct: 992 DETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLR 1051
Query: 129 ---EKVKTVLLSEAK--EEAKKGFEVEKVKMQQEIS----ELKGAKRQVEEALTLVIQAD 179
E+ K L + K +E+ E EK ++ +++ E+ + ++E+ L IQ
Sbjct: 1052 MDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQ 1111
Query: 180 KIKAAEIRSVYHLHQEEI-----TRIKKECER-EIRRLMEEIKFKDRAVFVLERELG--- 230
K K E+++ +EEI +R K E +R ++ R +EEI + LE G
Sbjct: 1112 K-KIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER------LEEAGGATS 1164
Query: 231 --VQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLD 288
++ + + QK D + + ++ ++ A G+ D+ +Q+L
Sbjct: 1165 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKL- 1223
Query: 289 EKDARRFQLKIAELSA--------------IIRKLEDRNALLSEERNELLKRVREAESQY 334
EK+ +++I +L++ + R LED+ + L + E + + + +Q
Sbjct: 1224 EKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQR 1283
Query: 335 KPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEM-RQRAGIIRRPSSLNDLDQSQD 393
L ++ SR+ ++ + ++ + TQ+ E+ RQ I+ ++L QS
Sbjct: 1284 GRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQS-S 1342
Query: 394 EREVDFLKLQIVEQQNLIDELSKTLETAG---------YVKSVLERDKLLRFRK----QR 440
+ D L+ Q E+Q EL + L A Y ++R + L K QR
Sbjct: 1343 RHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1402
Query: 441 KKMAKLPKPVVVETFFGYDE-EASLESDGSSVSYQTDRTDQTPCTPDD------------ 487
+ A+ V ++ + L+++ + +RT+ D
Sbjct: 1403 LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEW 1462
Query: 488 ---------DLEEGM---------------AKEETELRFRQLTMEYQALQRAYALLQEQV 523
+LE A EE+ + L E + LQ+ + L EQ+
Sbjct: 1463 KQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQI 1522
Query: 524 --GGTLDAEREVKTREQLQAEVQRAQARIEDLEKALA-EQGQ----DMKWIEEKQALYRR 576
GG E E K ++Q++ E QA +E+ E +L E+G+ ++ + K + R+
Sbjct: 1523 AEGGKRIHELE-KIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK 1581
Query: 577 NQELVEKIKQMETEEARLRHEVQ---DARDQNELLEFRILELEERERKSPAISFHHTPFV 633
E E+I Q++ R+ +Q DA ++ R+ + E + I +H +
Sbjct: 1582 IAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRM 1641
Query: 634 DGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNE---EQVVVIQARTVLTLAE-- 688
++ L+ Y +G+ +K I D+A + E EQ+ +++ R L AE
Sbjct: 1642 AAEA-LRNYRNTQGI--------LKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIE 1692
Query: 689 ---KWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEA 745
L+Q E + +++++D +L Q L ++ +K+ ++ E+E
Sbjct: 1693 ELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSL---INTKKKLETDISQMQGEMED 1749
Query: 746 MLYDALQQEAGAK--------VAELLSEEE-----REKLKVAVEQWKRQVMSELRERDAQ 792
+L +A E AK +AE L +E+ E++K +EQ + + L E +
Sbjct: 1750 ILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQL 1809
Query: 793 ILRERMELLQLAQQRIKELEERIEAQKRQIKE 824
L+ + +Q + R++ELE +E+++++ E
Sbjct: 1810 ALKGGKKQIQKLEARVRELEGEVESEQKRNAE 1841
Score = 91.7 bits (226), Expect = 3e-18
Identities = 177/868 (20%), Positives = 372/868 (42%), Gaps = 143/868 (16%)
Query: 21 LQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVRE-HEQHKTAVLLTELKTKL 79
LQ ++L+A++ +++ E++ E++ +K E++++ R++ E E+ + A T + ++
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1169
Query: 80 HEEKMKELQAVRETLLR---QHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVKTVLL 136
++++ E Q +R L QHEA + K + L + L
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNL------------- 1216
Query: 137 SEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEE 196
+ K+ E EK +M+ EI +L V +A + + +++
Sbjct: 1217 ----QRVKQKLEKEKSEMKMEIDDLASNVETVSKA-----------KGNLEKMCRTLEDQ 1261
Query: 197 ITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREA 256
++ +K + E E +RL+ ++ + L ++G R +KEAL QLS+ ++A
Sbjct: 1262 LSELKSK-EEEQQRLINDLTAQ-------RGRLQTESGEFSRQLDEKEALVSQLSRGKQA 1313
Query: 257 -DRHPGSPRRELPHAAGAGDASDHSGSPE--------QQLDEKDARRFQLKIA------E 301
+ +R+L A +A H+ +Q +E+ + +L+ A E
Sbjct: 1314 FTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTE 1373
Query: 302 LSAIIRKLE----DRNALLSEERNELLKRVREAESQYKPL------LDKNK-RLSRKNED 350
++ K E R L E + +L +R++ AE + + L+K K RL + ED
Sbjct: 1374 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVED 1433
Query: 351 LSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNL 410
L + R + ++ + ++ + ++E L ++ + +N
Sbjct: 1434 LMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNA 1493
Query: 411 IDELSKTLETAGYVKSVLERD------KLLRFRKQRKKMAKLPKPVVVETFFGYDEEASL 464
+E LET L+++ ++ K+ ++ K+ K V E + +A+L
Sbjct: 1494 YEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC---ELQAAL 1550
Query: 465 ESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVG 524
E +S+ ++ + + LE K E + + + E L+R + + E +
Sbjct: 1551 EEAEASLEHEEGKILRI------QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604
Query: 525 GTLDAERE-----VKTREQLQAEVQRAQARIEDLEKALAEQGQDMK---------WIEEK 570
TLDAE ++ +++++ ++ + ++ + AE ++ + I
Sbjct: 1605 STLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLD 1664
Query: 571 QALYRRNQELVEKIKQMETEEARLRHEVQDAR---DQNE----LLEFRILELEERERKSP 623
AL R ++L E++ +E L+ E+++ R +Q E + E +L+ ER +
Sbjct: 1665 DAL-RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ--- 1720
Query: 624 AISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKL-DILGDNANLTNEEQVVVIQART 682
+ +T ++ K L+ TDI +++ ++ DIL + N + + + A
Sbjct: 1721 LLHTQNTSLINTKKKLE--------TDI--SQMQGEMEDILQEARNAEEKAKKAITDAAM 1770
Query: 683 VLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQ-ALDQANKHIL 741
+AE+ L++ ++T A L+R ++E + L LD +Q AL K I
Sbjct: 1771 ---MAEE-LKKEQDTSAHLERMKKNMEQTVK-------DLQLRLDEAEQLALKGGKKQIQ 1819
Query: 742 ELEAMLYDALQQEAGAKVAELLSEEEREKLKVA-VEQWKRQVMSELRERDAQILRERMEL 800
+LEA +V EL E E E+ + A + R+ ++E Q +R +
Sbjct: 1820 KLEA------------RVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNI 1867
Query: 801 LQLAQQRIKELEERIEAQKRQIKELEEK 828
L+L Q + +L+ ++++ KRQ +E EE+
Sbjct: 1868 LRL-QDLVDKLQAKVKSYKRQAEEAEEQ 1894
Score = 78.6 bits (192), Expect = 2e-14
Identities = 168/853 (19%), Positives = 340/853 (39%), Gaps = 135/853 (15%)
Query: 9 RAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKT 68
+ + D EA +A LR K D EL ++ + +V+++ +E +++
Sbjct: 1179 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1238
Query: 69 AVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGP 128
+ + T K K + EKM + + L+ E E R+I + RLQ
Sbjct: 1239 SNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLD 1298
Query: 129 EKVKTV-LLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIR 187
EK V LS K+ + E K ++++EI + + AL +Q+ + +R
Sbjct: 1299 EKEALVSQLSRGKQAFTQQIEELKRQLEEEI--------KAKNALAHALQSSRHDCDLLR 1350
Query: 188 SVYHLHQEEITRIKKECEREIRRLMEEI-----KFKDRAVFVLERELGVQAGHAQRLQLQ 242
Y QE K E +R + + E+ K++ A+ E + AQRLQ
Sbjct: 1351 EQYEEEQES----KAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAA 1406
Query: 243 K---EALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKI 299
+ EA++ + + + + + + +L +A+ + +Q+ +K ++ K
Sbjct: 1407 EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKC 1466
Query: 300 AELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSH------ 353
E A + + L E ++ E+ Q + L +NK L ++ DL+
Sbjct: 1467 EETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGG 1526
Query: 354 -ALRRMENKLKFVTQENIEMRQRAGIIRRPSSLN---------DLDQSQDEREVDFLKLQ 403
+ +E K V QE E+ +A + +SL L+ +Q + EVD +
Sbjct: 1527 KRIHELEKIKKQVEQEKCEL--QAALEEAEASLEHEEGKILRIQLELNQVKSEVD---RK 1581
Query: 404 IVEQQNLIDELSKT-LETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEA 462
I E+ ID+L + + ++S L+ + +R R ++ K
Sbjct: 1582 IAEKDEEIDQLKRNHIRIVESMQSTLDAE--IRSRNDAIRLKK----------------- 1622
Query: 463 SLESDGSSVSYQTDRTDQTPCTPDDDLE--EGMAKEETELRFRQLTMEYQALQRAYALLQ 520
+E D + + Q + ++ + +G+ K +T++ + L+ A+++
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK-DTQIHLDDALRSQEDLKEQLAMVE 1681
Query: 521 EQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKA--LAEQGQDMKWIEEKQALYRRNQ 578
+ LQAE++ +A +E E++ +AEQ + + E Q L+ +N
Sbjct: 1682 RRA-------------NLLQAEIEELRATLEQTERSRKIAEQ-ELLDASERVQLLHTQNT 1727
Query: 579 ELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSP 638
L+ K++ET+ ++++ E++D L E R EE+ +K+
Sbjct: 1728 SLINTKKKLETDISQMQGEMEDI-----LQEAR--NAEEKAKKA---------------- 1764
Query: 639 LQVYCEAEGVTD--IVVAELMKKLDILGDNANL-TNEEQVVVIQARTVLTLAEKWLQQIE 695
+TD ++ EL K+ D + N EQ T+ + L+ E
Sbjct: 1765 ---------ITDAAMMAEELKKEQDTSAHLERMKKNMEQ----------TVKDLQLRLDE 1805
Query: 696 ETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEA 755
+ AL+ ++ + + +G ++ E +A+ KH ++ + Y +
Sbjct: 1806 AEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRK 1865
Query: 756 GAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERI 815
L ++ +KL+ V+ +KRQ + + + + R Q ++E EER
Sbjct: 1866 NI----LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRK-----LQHELEEAEERA 1916
Query: 816 EAQKRQIKELEEK 828
+ + Q+ +L K
Sbjct: 1917 DIAESQVNKLRVK 1929
Score = 68.6 bits (166), Expect = 2e-11
Identities = 148/669 (22%), Positives = 283/669 (42%), Gaps = 114/669 (17%)
Query: 181 IKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQ 240
+K+AE +EE +IK E + E K K+ LE ++ LQ
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKS------EAKRKE-----LEEKMVTLLKEKNDLQ 894
Query: 241 LQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIA 300
LQ +A E L+ E R + ++ A + + E+ DE++ A
Sbjct: 895 LQVQAEAEGLADAEE--RCDQLIKTKIQLEAKIKEVT------ERAEDEEEIN------A 940
Query: 301 ELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMEN 360
EL+A RKLED + L ++ ++L + + E + +K K L+ + L + ++
Sbjct: 941 ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK 1000
Query: 361 KLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLET 420
+ K + + + +L+DL +D +V+ L ++ + +D+L +LE
Sbjct: 1001 EKKALQEAH------------QQTLDDLQAEED--KVNTLTKAKIKLEQQVDDLEGSLEQ 1046
Query: 421 AGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQ 480
++ LER K ++ + KL + +++ + + + D+
Sbjct: 1047 EKKLRMDLERAK-----RKLEGDLKLAQESIMD-----------------IENEKQQLDE 1084
Query: 481 TPCTPDDDLEEGMAKEETELRFR-QLTMEYQALQRAYALLQEQVGGTLDAER-----EVK 534
+ ++ +K E E QL + + LQ L+E++ +AER K
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI----EAERASRAKAEK 1140
Query: 535 TREQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARL 594
R L E++ R+E+ A + Q + K E + RR +L E Q E A L
Sbjct: 1141 QRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR--DLEEATLQHEATAATL 1198
Query: 595 RHE----VQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTD 650
R + V + +Q + L+ R+ + E+E+ + D S ++ +A+G +
Sbjct: 1199 RKKHADSVAELGEQIDNLQ-RVKQKLEKEKSEMKMEID-----DLASNVETVSKAKGNLE 1252
Query: 651 IVVAELMKKLDILGDNANLTNEEQVVVI-----QARTVLTLAEKWLQQIEETEAALQRKM 705
+ L +L L EEQ +I Q + T + ++ +Q++E EA + +
Sbjct: 1253 KMCRTLEDQLSELKSK----EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ-- 1306
Query: 706 VDLESEKELFSKQ----KGYLDEELDYRKQALD---QANKHILELEAMLYDALQQEAGAK 758
L K+ F++Q K L+EE+ K AL Q+++H +L Y+ +QE+ A+
Sbjct: 1307 --LSRGKQAFTQQIEELKRQLEEEIK-AKNALAHALQSSRHDCDLLREQYEE-EQESKAE 1362
Query: 759 VAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQ 818
+ LS+ E V QW+ + ++ +R ++ + +L QR++ EE +EA
Sbjct: 1363 LQRALSKANTE-----VAQWRTKYETDAIQRTEELEEAKKKL----AQRLQAAEEHVEAV 1413
Query: 819 KRQIKELEE 827
+ LE+
Sbjct: 1414 NAKCASLEK 1422
Score = 59.3 bits (142), Expect = 1e-08
Identities = 80/409 (19%), Positives = 177/409 (43%), Gaps = 42/409 (10%)
Query: 6 MSSRAKGDKAEALAALQAANEDLR---AKLTDIQIELQQEKSKVSKVEREKNQELRQVRE 62
+ + + +K E AAL+ A L K+ IQ+EL Q KS+V + EK++E+ Q++
Sbjct: 1535 IKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR 1594
Query: 63 HEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRV-IKIKDNENQRLQALLS 121
+ ++ +++ L E A+R L ++ E +L + I++ +AL +
Sbjct: 1595 NHIR----IVESMQSTLDAEIRSRNDAIR--LKKKMEGDLNEMEIQLNHANRMAAEALRN 1648
Query: 122 ALRDGGPEKVKTVLLSEA---KEEAKKGFEVEKVK---MQQEISELKGAKRQVEEALTLV 175
G K + L +A +E+ K+ + + + +Q EI EL+ Q E + +
Sbjct: 1649 YRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1708
Query: 176 IQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGH 235
Q + + A+E + H + KK+ E +I ++ E++ +L+ +
Sbjct: 1709 EQ-ELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEME------DILQEARNAEE-K 1760
Query: 236 AQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRF 295
A++ + E+L + ++ H ++ + + QL +A +
Sbjct: 1761 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTV-----------KDLQLRLDEAEQL 1809
Query: 296 QLK-----IAELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNED 350
LK I +L A +R+LE + E +K +R+ E + K L + + +
Sbjct: 1810 ALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILR 1869
Query: 351 LSHALRRMENKLKFVTQ--ENIEMRQRAGIIRRPSSLNDLDQSQDEREV 397
L + +++ K+K + E E + + + ++L+++++ ++
Sbjct: 1870 LQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADI 1918
Score = 49.7 bits (117), Expect = 1e-05
Identities = 69/305 (22%), Positives = 142/305 (46%), Gaps = 27/305 (8%)
Query: 538 QLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHE 597
+ + E+ + + ++ LA+ K +EEK + + ++ Q E E E
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 598 VQDARDQNEL-LEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEA--EGVTDI--V 652
D + ++ LE +I E+ ER I+ T K L+ C + + D+
Sbjct: 910 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTA---KKRKLEDECSELKKDIDDLELT 966
Query: 653 VAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEK 712
+A++ K+ + EE + + LT +K LQ+ A Q+ + DL++E+
Sbjct: 967 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE------AHQQTLDDLQAEE 1020
Query: 713 E---LFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVA-ELLSEEER 768
+ +K K L++++D + +L+Q K ++LE + E K+A E + + E
Sbjct: 1021 DKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERA---KRKLEGDLKLAQESIMDIEN 1077
Query: 769 EKLKVAVEQWKRQ-----VMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIK 823
EK ++ + K++ + S++ + A ++ + ++ +L Q RI+ELEE IEA++
Sbjct: 1078 EKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKEL-QARIEELEEEIEAERASRA 1136
Query: 824 ELEEK 828
+ E++
Sbjct: 1137 KAEKQ 1141
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 105 bits (263), Expect = 1e-22
Identities = 180/827 (21%), Positives = 347/827 (41%), Gaps = 131/827 (15%)
Query: 36 QIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLTELKTKLHEEKMKELQAVRETLL 95
QI+ +E+ + E++KN+E Q E+E++ LL+++ TK E KM + + + LL
Sbjct: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKN---TLLSQISTKDGELKMLQEEVTKMNLL 1897
Query: 96 RQH-EAELLRVIKIK-------DNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGF 147
Q + EL RV K+K D+ +RL L+ L + V ++ K E
Sbjct: 1898 NQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNEL---L 1954
Query: 148 EVEKVKMQQEISELKGAKRQVEEALTLVIQA------DKIKAAEIRSVYHLHQEEITRIK 201
E E +++ +SEL+ K+Q+ + T V +KI+ A+ H +E+ +
Sbjct: 1955 ESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELL 2014
Query: 202 KECEREIRRLMEEIKFKDRAVFVLERELG----VQAGHAQRLQLQKEALDEQLSQVREAD 257
KE ++E+++L ++ + LER + VQ + L++ KE L + + ++A
Sbjct: 2015 KEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQ 2074
Query: 258 RHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLS 317
AEL++ L+D + +
Sbjct: 2075 ------------------------------------------AELASFKVLLDDTQSEAA 2092
Query: 318 EERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAG 377
+ LK +E +S + + ++ +K+EDL L + E K +E M+++
Sbjct: 2093 RVLADNLKLKKELQSNKESV---KSQMKQKDEDLERRLEQAEEKH---LKEKKNMQEKLD 2146
Query: 378 IIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTL-ETAGYVKSVL----ERDK 432
+RR L+++ E +V K E Q L + L T+ + A + KS+ +RD+
Sbjct: 2147 ALRREKV--HLEETIGEIQVTLNKKD-KEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDR 2203
Query: 433 LL-RFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEE 491
++ +K +K + + +EE L+ D SV D +
Sbjct: 2204 VIDEAKKWERKFS--------DAIQSKEEEIRLKEDNCSV------------LKDQLRQM 2243
Query: 492 GMAKEETELRFRQLTMEYQALQ---RAYALLQEQVGGTLDAER-----EVKTREQLQAEV 543
+ EE ++ +L + Q + + LQ++V TL E +++ L
Sbjct: 2244 SIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSS 2303
Query: 544 QRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQDARD 603
Q A++E K+L +Q D+ EK + N E + I+Q Q+A
Sbjct: 2304 QNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGI--IRQ------------QEADI 2349
Query: 604 QNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDI- 662
QN + LE + + + H + + + + E + +AEL ++ D
Sbjct: 2350 QNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKE 2409
Query: 663 LGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYL 722
+ + NL ++E+ I A Q+ ET ++++ + +++ + F K L
Sbjct: 2410 IKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSL 2469
Query: 723 DEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQV 782
+ D Q + L + + D L QEA A+ +L +EE L+ ++ +
Sbjct: 2470 QNDRDRIVGDYQQLEERHLSI-ILEKDQLIQEAAAENNKL--KEEIRGLRSHMDD----L 2522
Query: 783 MSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEKF 829
SE + DA++++ R +L Q+ + + ++ +E Q +Q KELE K+
Sbjct: 2523 NSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKY 2569
Score = 85.1 bits (209), Expect = 2e-16
Identities = 185/909 (20%), Positives = 369/909 (40%), Gaps = 127/909 (13%)
Query: 1 MSKRGMSSRAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQV 60
+SK SS + + E + E+L + L + Q E+ S E E+ ++Q
Sbjct: 132 LSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQ 191
Query: 61 REHEQHKTAVLLTELKTKLHEEK----MKELQAVRETLLRQHEAELLRVIKIKDNE---N 113
+ ++ + L +L E+ ++E A ET +R HE ELL+++ D E
Sbjct: 192 LQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQ 251
Query: 114 QRLQALLSALRDG-----GPEKVKTVLLSE--AKEEAKKGFEVEKVKMQQEISELKGAKR 166
Q+L+ L L + G +V +L E A E+ + + +M+ E + L+
Sbjct: 252 QKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVE 311
Query: 167 QVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECER------EIRRLMEEIKFKDR 220
E ++++ +++ AE + +H QEE+ + ++ E+ E+ ++ K +
Sbjct: 312 TEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHK 371
Query: 221 AVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHS 280
A E+ + H LQ + L +++ + + E + S
Sbjct: 372 A------EMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNE---------QAVQS 416
Query: 281 GSPEQQLDEKDARRFQLKIAELSAIIRKL------------------EDRNALLSEERNE 322
QQL++ + Q K E+S + +L E A+ E
Sbjct: 417 AQTIQQLED----QLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIAS 472
Query: 323 LLKRVREAESQYKPLLDKN---KRLSRKNEDLSHALRRME--NKLKFVTQENIEMRQRAG 377
L KRV E E++ LL + + L +NE LS + +E N+ +E E+
Sbjct: 473 LQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDI 532
Query: 378 IIRRPSSLNDLDQ-------SQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLER 430
+R SS + Q SQ +E+ L L++ E Q I L L+ K E
Sbjct: 533 ANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQG----KRAEEA 588
Query: 431 DKLLRFRKQRKKM-AKLPKPVVVETFF---GYD------EEASL---ESDGSSVSYQTDR 477
D + +K+ K+M + P+ ++ F G D EE+SL E + +S +Q+ R
Sbjct: 589 DHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQS-R 647
Query: 478 TDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREV-KTR 536
T + D +E K++ + + Q Q L+ Q+ L+ E K +
Sbjct: 648 TSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQI---LELELNFHKAQ 704
Query: 537 EQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEK-QALYRRNQELVEKIKQMETEEARLR 595
E + + I +L + + E ++ AL +L+ ++K++
Sbjct: 705 EIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSM------ 758
Query: 596 HEVQDARDQNELLEFRILELEERERKS-PAISFHHTPFVDGKSPLQVYCEAEGVTDIVVA 654
V + R Q + LE + E E + R + + H + L + +++ D+ +
Sbjct: 759 --VTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSK---DVKIE 813
Query: 655 ELMKKLD------------ILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQ 702
L +LD I + L N+E V+ A V ++ K +EE AL
Sbjct: 814 VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSK----VEELSQALS 869
Query: 703 RKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYD---ALQQEAGAKV 759
+K +++ +L ++K +++ +Q +++ ++ + E+ + + L +E +
Sbjct: 870 QKELEITKMDQLLLEKK----RDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLG 925
Query: 760 AELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQK 819
E+ + +E+ L E+ K++ + E E + + + E+ Q +EL+ + K
Sbjct: 926 VEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLK 985
Query: 820 RQIKELEEK 828
++ ++ + K
Sbjct: 986 KENEQRKRK 994
Score = 80.9 bits (198), Expect = 5e-15
Identities = 183/947 (19%), Positives = 391/947 (41%), Gaps = 170/947 (17%)
Query: 6 MSSRAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQ 65
+S +G+ E + + + + +K +I+I L+Q S EK EL+ +R+ +
Sbjct: 1029 LSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTIS-------EKEVELQHIRKDLE 1081
Query: 66 HKTAVLLTELKTKLHEEKMKEL-QAVRETLLRQHEAELLRVIKIKDNENQRL-QALLSAL 123
K A EE+ + L + + +TL Q + + +++ + +ENQ + Q L+++
Sbjct: 1082 EKLAA----------EEQFQALVKQMNQTL--QDKTNQIDLLQAEISENQAIIQKLITSN 1129
Query: 124 RDGGPEKV-----KTVLLSE----AKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALT- 173
D +TV++S + E K E + + +++E +L+ ++++EALT
Sbjct: 1130 TDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQ---KKLQEALTS 1186
Query: 174 --LVIQADKIKAAEIRSV-------YHLHQEEITRIKKECER---EIRRLMEEIKFK-DR 220
+++ + K +R Y+ QE+ KE E ++R+L +++ D
Sbjct: 1187 RKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDG 1246
Query: 221 AVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHS 280
+ +++ + L K V E++ P P +A G S
Sbjct: 1247 KLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQ 1306
Query: 281 GSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERN------ELLKRV-REAE-- 331
+ + E + +LK++ ++ + K + L E+ N E LK V EAE
Sbjct: 1307 IKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVH 1366
Query: 332 ---------------------SQYKPLLDK-NKRLSRKNEDLSHALRRMENKLKFVTQEN 369
+ +P LD+ K +S+K ED+S+ ++ K +T+
Sbjct: 1367 AESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQ 1426
Query: 370 IEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVK---- 425
E+ ++ +I+ + ++ + + + L++++ E + +E+ + ++
Sbjct: 1427 TEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQ 1486
Query: 426 -SVLERDKLLRFRKQRKKMAKLPKPVV---------VETFFGYDEE---------ASLES 466
+++ R + L+ K ++ L + + VE+ + A L+
Sbjct: 1487 AALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQE 1546
Query: 467 DGSSVSYQTDRT---DQTPCTPDDDLE---EGMAKEETEL-------------------- 500
+ + + DR+ +Q+ + + L+ EG+ +++ +L
Sbjct: 1547 ERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQE 1606
Query: 501 RFRQLTMEYQALQRAYALLQ---EQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKAL 557
+ ++L EY+ L ++Y + E++ ++A R+ K ++L +++ +A ++ EK L
Sbjct: 1607 KHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEK--QELYGKLRSTEANKKETEKQL 1664
Query: 558 AEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQDARD-----QNELLEFRI 612
E Q+M+ ++EK + ++++ +KI ++E E RLR EV A D LL
Sbjct: 1665 QEAEQEMEEMKEKMRKFAKSKQ--QKILELEEENDRLRAEVHPAGDTAKECMETLLSSNA 1722
Query: 613 LELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNE 672
EE ER V E E ++ LM + D L +
Sbjct: 1723 SMKEELER--------------------VKMEYETLSK-KFQSLMSEKDSLSEEVQDLKH 1761
Query: 673 EQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQA 732
+ + + L EK Q TE Q + E + L + E + K A
Sbjct: 1762 QIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSA 1821
Query: 733 LDQANKHILELEAMLYDALQQ--EAGAKVAELLSEEEREK-LKVAVEQWKRQVMSELRER 789
+K + + + LQQ + ++A L E+++ K +E K ++S++ +
Sbjct: 1822 NPAVSKDFSSHDE-INNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTK 1880
Query: 790 DAQI--LRERMELLQLAQQRIKELEERI----EAQKRQIKELEEKFL 830
D ++ L+E + + L Q+I+E R+ E + + +LEE+ +
Sbjct: 1881 DGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLM 1927
Score = 80.1 bits (196), Expect = 8e-15
Identities = 170/866 (19%), Positives = 357/866 (41%), Gaps = 129/866 (14%)
Query: 29 RAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKT--AVLLTELKTKLHEE---- 82
+AKLT + +++ K++ V + Q Q+ +H++ T + + ++K KL E+
Sbjct: 101 KAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELI 160
Query: 83 --------------------KMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSA 122
+M+E +++ L Q + E + ++ + ++ Q QA
Sbjct: 161 STLQAQLTQAQAEQPAQSSTEMEEFVMMKQQL--QEKEEFISTLQAQLSQTQAEQAAQQV 218
Query: 123 LRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIK 182
+R+ V L E + + +MQQ++ L+ + EE+L Q +
Sbjct: 219 VREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLL 278
Query: 183 AAEIRSVYHLHQEEITRIKK-ECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQL 241
E+ + +Q ++++ E E R E + ++ + + + EL V A+R +L
Sbjct: 279 QQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEV----AER-KL 333
Query: 242 QKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIA- 300
L E++ + E G + EL A + + +++EK + L+
Sbjct: 334 SFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKH-----KAEMEEKTSHILSLQKTG 388
Query: 301 -ELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRME 359
EL + L+D+N+ L +++NE +A + + +L +K++++S L R+
Sbjct: 389 QELQSACDALKDQNSKLLQDKNE------QAVQSAQTIQQLEDQLQQKSKEISQFLNRLP 442
Query: 360 NKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLE 419
++ + A P N+ Q+ E + L+ ++VE +N E
Sbjct: 443 ----------LQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELEN---------E 483
Query: 420 TAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLE-SDGSSVSYQTDRT 478
+ S +E ++L + + KL + + EA E S+ S V R+
Sbjct: 484 KGALLLSSIELEEL------KAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRS 537
Query: 479 DQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQ 538
+ D LE +++ EL L M+ + A+ LQ Q +A+ EV +++
Sbjct: 538 SSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKE 597
Query: 539 LQAEVQRAQARIEDLEKALAEQGQD----------MKWIEEKQALYRRNQELVEKIKQME 588
++ A I+ ++ L + GQD + +E++QA E+I +
Sbjct: 598 MKQMEGEGIAPIK-MKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEI-SLN 655
Query: 589 TEEARLRHEVQDA--------------RDQNELLEFRILELEERERKSPAISFHHTPFVD 634
L+ QD +D+ E L+ +ILELE ++FH +
Sbjct: 656 DAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELE--------LNFHKAQEIY 707
Query: 635 GKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQI 694
K+ + E + + + E K D +EE+ ++ L++ + Q+
Sbjct: 708 EKNLDEKAKEISNLNQL-IEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQV 766
Query: 695 EETEAAL----QRKMVDLESE---KELFSKQKGYL-------DEELDYRKQALDQANKHI 740
++ E L +++ +D ES+ L ++Q L D +++ + LD
Sbjct: 767 KQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQF 826
Query: 741 LELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMEL 800
E ++ L +LQ + K +E+L ER + + ++ L +++ +I +M+
Sbjct: 827 SE-QSTLIRSLQSQLQNKESEVLEGAERVR---HISSKVEELSQALSQKELEI--TKMDQ 880
Query: 801 LQLAQQR-IKELEERIEAQKRQIKEL 825
L L ++R ++ L++ IE + +Q+ E+
Sbjct: 881 LLLEKKRDVETLQQTIEEKDQQVTEI 906
Score = 79.0 bits (193), Expect = 2e-14
Identities = 179/871 (20%), Positives = 351/871 (40%), Gaps = 183/871 (21%)
Query: 12 GDKAEALAALQAANEDLRAKLTDIQ---IELQQEKSKVSKVEREKNQELRQVREHEQHKT 68
G+ + + Q NE L +++ +++ EL++EK ++ K EK + ++R+ K
Sbjct: 1938 GNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVK---EKTKVESEIRKEYLEKI 1994
Query: 69 AVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGP 128
E K H ++++EL ++ ++Q + + + R Q +SAL
Sbjct: 1995 QGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCI-----------RYQEKISALE---- 2039
Query: 129 EKVKTV-LLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIR 187
+TV L + E++K E+ K + Q + K A+ ++ + +++ + +AA +
Sbjct: 2040 ---RTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAEL-ASFKVLLDDTQSEAARVL 2095
Query: 188 SVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALD 247
+ + ++KKE + + ++K KD LER L ++A +
Sbjct: 2096 A-------DNLKLKKELQSNKESVKSQMKQKDED---LERRL-------------EQAEE 2132
Query: 248 EQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLK------IAE 301
+ L + + + RRE H + G + L++KD QL+ + +
Sbjct: 2133 KHLKEKKNMQEKLDALRREKVH------LEETIGEIQVTLNKKDKEVQQLQENLDSTVTQ 2186
Query: 302 LSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENK 361
L+A + + L ++R+ ++ ++ E ++ + + R ED L+
Sbjct: 2187 LAAFTKSMSS----LQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQ--- 2239
Query: 362 LKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETA 421
+ Q +I M + I R + +S+ + EV QQ + D L +
Sbjct: 2240 ---LRQMSIHMEELKINISRLEHDKQIWESKAQTEVQL-------QQKVCDTLQGENKE- 2288
Query: 422 GYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQT 481
+ S LE + L + + ++AKL E SL+ + +S ++
Sbjct: 2289 --LLSQLEETRHL-YHSSQNELAKLE-----------SELKSLKDQLTDLSNSLEK---- 2330
Query: 482 PCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTR--EQL 539
C EG+ RQ + Q + +Y EQ+ L A RE+ +R E++
Sbjct: 2331 -CKEQKGNLEGI--------IRQQEADIQNSKFSY----EQLETDLQASRELTSRLHEEI 2377
Query: 540 QAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQ 599
+ Q+ + + E+A+ +++ +K+ +EL + Q E E L E +
Sbjct: 2378 NMKEQKIISLLSGKEEAIQVAIAELRQQHDKEI-----KELENLLSQEEEENIVLEEENK 2432
Query: 600 DARDQ-NELLE-FRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELM 657
A D+ N+L+E + ++ E ++K+ S FV S LQ
Sbjct: 2433 KAVDKTNQLMETLKTIKKENIQQKAQLDS-----FVKSMSSLQ----------------N 2471
Query: 658 KKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSK 717
+ I+GD L ++++ ++ A +++E L+ M DL SE
Sbjct: 2472 DRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDA 2531
Query: 718 QKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEER--------- 768
+ E+L+ D K +LE++ L+ + AK+ E L E E
Sbjct: 2532 ELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKY-AKLEEKLKESEEANEDLRRSF 2590
Query: 769 --------------EKLKVAVEQWKRQVM------------SELRERDAQILRERMELLQ 802
E LKV++ Q RQV ++L+ ++ ++ R L
Sbjct: 2591 NALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHR-LSALFS 2649
Query: 803 LAQQRIKELEERI-----EAQKRQIKELEEK 828
+Q+RI ELEE + EA K+ + E+E+K
Sbjct: 2650 SSQKRIAELEEELVCVQKEAAKK-VGEIEDK 2679
Score = 77.8 bits (190), Expect = 4e-14
Identities = 192/971 (19%), Positives = 388/971 (39%), Gaps = 188/971 (19%)
Query: 16 EALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLTEL 75
+ L A + N+ L +L ++ E ++ V + ERE+++ L + E E + + L
Sbjct: 280 QELTAAEQRNQILSQQLQQMEAEHNTLRNTV-ETEREESKILLEKMELEVAERKLSFHNL 338
Query: 76 KTKLHE---------EKMKELQAVRETLLRQHEAELLRV---IKIKDNENQRLQALLSAL 123
+ ++H + EL++ L ++H+AE+ I Q LQ+ AL
Sbjct: 339 QEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDAL 398
Query: 124 RDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKA 183
+D + LL + E+A + + +QQ +L+ +++ + L + + +
Sbjct: 399 KDQNSK-----LLQDKNEQAVQSAQT----IQQLEDQLQQKSKEISQFLNR-LPLQQHET 448
Query: 184 AEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQK 243
A S ++ E + +E +++ + E++ + A+ + EL + L+ +
Sbjct: 449 ASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIEL-------EELKAEN 501
Query: 244 EALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELS 303
E L Q++ + EA G RE+ + A+ S S E+ + F K ELS
Sbjct: 502 EKLSSQITLL-EAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELS 560
Query: 304 AIIRKLEDRNALLSEERNELL-KRVREAESQYKPLLDKNKRLSRKNEDLSHALRRM---- 358
++ ++++ ++ + +L KR EA+ + +LD+ + + E ++ ++
Sbjct: 561 VLLLEMKEAQEEIAFLKLQLQGKRAEEADHE---VLDQKEMKQMEGEGIAPIKMKVFLED 617
Query: 359 -----------ENKLKFVTQENIEMRQRAGI----------IRRPSSLNDLDQS------ 391
E+ L V +E ++ + S+ D D+S
Sbjct: 618 TGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPD 677
Query: 392 -----QDERE----------VDFLKLQIVEQQNL-------------IDELSKTLETAGY 423
QDE E ++F K Q + ++NL I+E K +
Sbjct: 678 IGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSS 737
Query: 424 VKSVL--ERDKLLRFRKQRKKMAKLPKPVV-VETFFGYDEEASLESDGSSVSYQTDRTDQ 480
+ L ERD+LL K+ + +L V +E E S ++ T+Q
Sbjct: 738 AFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQ 797
Query: 481 TPCTPDDDLEEGMAKE-------ETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREV 533
+ + + E + +L+F + + ++LQ + +V + R +
Sbjct: 798 IHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHI 857
Query: 534 KTR-EQLQAEVQRAQARIEDLEKALAEQGQDMKW----IEEK-QALYRRNQELVEKIKQM 587
++ E+L + + + I +++ L E+ +D++ IEEK Q + + + EK+ Q+
Sbjct: 858 SSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQL 917
Query: 588 ETEEARLRHEVQDARDQNELL--------------------------------------- 608
E+ L E++ ++Q LL
Sbjct: 918 NEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEEL 977
Query: 609 --EFRIL--ELEERERKSPAISFHHTPFVDGKSPLQ---VYCEAEGVTDIVVAELMKKLD 661
EF +L E E+R+RK A + + S L+ + E +I ++E ++ +
Sbjct: 978 QHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSET-ERGE 1036
Query: 662 ILGDNANLTNEEQVVVIQARTVLTLAEKWLQQ-IEETEAALQRKMVDLESE---KELFSK 717
+ D N E+ V + + + E +L+Q I E E LQ DLE + +E F
Sbjct: 1037 VEEDKENKEYSEKCVTSKCQEI----EIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQA 1092
Query: 718 QKGYLDEELDYRKQALDQANKHILELEAMLY-------DALQQEAGAKVAELLS------ 764
+++ L + +D I E +A++ DA ++ A V E +
Sbjct: 1093 LVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCT 1152
Query: 765 ------EEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQ 818
+ E E+ +A+E+ K Q+ +L+E L R +L+ AQ++ + L E ++ Q
Sbjct: 1153 GSSEHWKPELEEKILALEKEKEQLQKKLQEA----LTSRKAILKKAQEKERHLREELKQQ 1208
Query: 819 KRQIKELEEKF 829
K L+E+F
Sbjct: 1209 KDDYNRLQEQF 1219
Score = 76.6 bits (187), Expect = 9e-14
Identities = 174/902 (19%), Positives = 358/902 (39%), Gaps = 119/902 (13%)
Query: 18 LAALQAANEDLRAKLTDIQIELQ---QEKSKVSKVEREKNQELRQVR-EHEQHKTAVLLT 73
LA L++ + L+ +LTD+ L+ ++K + + R++ +++ + +EQ +T + +
Sbjct: 2307 LAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQAS 2366
Query: 74 -ELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKV- 131
EL ++LHEE + Q + L + EA + + +++ ++ ++ L + L E +
Sbjct: 2367 RELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIV 2426
Query: 132 ----------KTVLLSEAKEEAKK----------GFEVEKVKMQQEISELKGAKRQVEEA 171
KT L E + KK F +Q + + G +Q+EE
Sbjct: 2427 LEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEER 2486
Query: 172 -LTLVIQADKI--KAA--------EIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDR 220
L+++++ D++ +AA EIR + H +++ + + E+ + E++ ++
Sbjct: 2487 HLSIILEKDQLIQEAAAENNKLKEEIRGL-RSHMDDLNSENAKLDAELIQYREDL---NQ 2542
Query: 221 AVFVLERE----LGVQAGHAQRLQLQKEALDEQLSQVREADR-----------HPGSPRR 265
+ + + + L VQ + L+ + L+E+L + EA+ +
Sbjct: 2543 VITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSK 2602
Query: 266 ELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAE-----LSAIIRKLEDRNALLSEE- 319
E+ + + Q+ QLK+ E LSA+ + R A L EE
Sbjct: 2603 EIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEEL 2662
Query: 320 ---RNELLKRVREAESQYKPLL-----------DKNKRLSRKNEDLSHALRRMENKLKFV 365
+ E K+V E E + K L ++ + + +L+ L ME KL V
Sbjct: 2663 VCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMV 2722
Query: 366 TQENIEMRQRAGIIRRPSSLNDLDQSQD--EREVDFLK----------LQIVEQQNLIDE 413
T+EN + + R S++ L S+D E+D LK Q+ EQ L E
Sbjct: 2723 TKENKGLTAQIQSFGR--SMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRE 2780
Query: 414 LSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSY 473
L + + E + L K +++ + ++ + D ++S +++
Sbjct: 2781 RDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMAS 2840
Query: 474 QTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREV 533
+ D + + K+ + + E Q+L++A + LQ D +R +
Sbjct: 2841 LQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQN------DRDRLL 2894
Query: 534 KTREQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEAR 593
K + LQ + + I +L A+ ++E Q + Q + E+++Q E
Sbjct: 2895 KELKNLQQQYLQINQEITELHPLKAQ-------LQEYQDKTKAFQIMQEELRQ---ENLS 2944
Query: 594 LRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVV 653
+HE+ R E + I E +E+ AIS ++ ++ + T +
Sbjct: 2945 WQHELHQLR--MEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLK 3002
Query: 654 AELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQR---KMVDLES 710
+ ++ + + + Q +V + + T L++I + E +Q+ L
Sbjct: 3003 VQYQRQAS--PETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLE 3060
Query: 711 EKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREK 770
EK S Q + L +Q H LE + + VA +E+
Sbjct: 3061 EKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGV 3120
Query: 771 LKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQ------KRQIKE 824
+ + + R+ E Q+ R E+ +L + +E ++R+ A+ + QI+
Sbjct: 3121 HRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRR 3180
Query: 825 LE 826
LE
Sbjct: 3181 LE 3182
Score = 66.6 bits (161), Expect = 9e-11
Identities = 145/693 (20%), Positives = 281/693 (40%), Gaps = 130/693 (18%)
Query: 7 SSRAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQEL----RQVRE 62
S A D + ALQ +DL ++ +++ + Q +V+ ++ E L +V+E
Sbjct: 2579 SEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKE 2638
Query: 63 HEQHKTAVL-------LTELKTKL---HEEKMKELQAVRETLLRQ-----HEAELLRVIK 107
E H+ + L + EL+ +L +E K++ + + L ++ H+A ++R
Sbjct: 2639 EEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMR--- 2695
Query: 108 IKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQ 167
NE + + ++ L E ++ LL KE KG + + +S L+ ++
Sbjct: 2696 ---NETETAEERVAELARDLVE-MEQKLLMVTKE--NKGLTAQIQSFGRSMSSLQNSRDH 2749
Query: 168 VEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKE--CEREIRRLMEEIKFKDRAVFVL 225
E L E++ Y +E+ ++K++ RE L+ E F +
Sbjct: 2750 ANEELD-----------ELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNS--TE 2796
Query: 226 ERELGVQAGHAQRLQLQKEALDEQL----SQVREADRHPGSPRRELPHAAGAGDASDHSG 281
E L H ++L Q + DEQL SQ+ ++ S + + A + DH
Sbjct: 2797 ENSL----SHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAM---ASLQNERDHLW 2849
Query: 282 SPEQQL--DEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPL-- 337
+ ++ E+ +R + + A ++ L+ + L +R+ LLK ++ + QY +
Sbjct: 2850 NELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909
Query: 338 ----LDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQD 393
L K ++ +D + A + M+ +L+ QEN+ + +R S ++ + +
Sbjct: 2910 EITELHPLKAQLQEYQDKTKAFQIMQEELR---QENLSWQHELHQLRMEKSSWEIHERRM 2966
Query: 394 ERE----VDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKP 449
+ + + Q+ QNLI EL +S + + L+ + QR+
Sbjct: 2967 KEQYLMAISDKDQQLSHLQNLIREL----------RSSSSQTQPLKVQYQRQA------- 3009
Query: 450 VVVETFFGYDEEASLESDGS-SVSYQTD--RTDQTPCTPDDDLEEGMAKEETELRFRQLT 506
E S DGS ++ Y+T+ RT +D L+E + ELR +QL
Sbjct: 3010 ---------SPETSASPDGSQNLVYETELLRTQL-----NDSLKE---IHQKELRIQQLN 3052
Query: 507 MEYQALQRAYALLQEQVGGTLDAEREVKTR--------EQLQAEVQRAQARIEDL----- 553
+ L L Q+ T + RE + L+ +VQ QA ++
Sbjct: 3053 SNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPG 3112
Query: 554 ---EKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEF 610
EK + D + + E Q + Q+ + +Q E LR +++ RDQ E
Sbjct: 3113 APQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQ---EVNELRKLLEEERDQRVAAEN 3169
Query: 611 RILELEERERKSPAISFHHTPFVDGKSPLQVYC 643
+ EE+ R+ H+ + ++P+ C
Sbjct: 3170 ALSVAEEQIRR-----LEHSEWDSSRTPIIGSC 3197
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 105 bits (262), Expect = 2e-22
Identities = 182/869 (20%), Positives = 380/869 (43%), Gaps = 98/869 (11%)
Query: 18 LAALQAANEDLRAKLTDIQI---ELQQEKSKVSKVEREKNQELR---QVREHE--QHKTA 69
L L+ N+ L + +++ ++ SK+ K+E+E NQ L ++ E+E Q K +
Sbjct: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKE-NQRLSKKVEILENEIVQEKQS 520
Query: 70 VLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGP- 128
+ + +K ++ +L+ ETL E R IKI + EN+ L +S+LR
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSE----RQIKILEQENEHLNQTVSSLRQRSQI 576
Query: 129 ---------EKVKTVLLSEAKEEAKK--GFEVEKVKMQQEISELKGAKRQVEEALTLVIQ 177
EK +L KE + K E EK ++++E+ K + EE +
Sbjct: 577 SAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHH 636
Query: 178 ADKIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQ 237
+K L Q++IT +K CE+ I L +E +R R+L +
Sbjct: 637 LEKEN--------ELLQKKITNLKITCEK-IEALEQENSELERE----NRKLKKTLDSFK 683
Query: 238 RLQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLD-EKDARRFQ 296
L Q E+L+++ SQ+ E + RR + A ++L+ EK+ +
Sbjct: 684 NLTFQLESLEKENSQLDEENLEL---RRNVESLKCASMKMAQLQLENKELESEKEQLKKG 740
Query: 297 LKIAE--------LSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKN 348
L++ + L + L+ N L + K++++ ES+ + L +N+ L +
Sbjct: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL 800
Query: 349 EDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQ 408
E+L + +R+E + +EN + Q + + + + + ++ + +K +E+
Sbjct: 801 EELKISSKRLEQ----LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE-IKDTTLEEN 855
Query: 409 NL----IDELSKTL--ETAGYVKSVLERDKLLRFRKQRKKMAKLP-KPVVVETFFGYDEE 461
N+ +++ +KTL E Y +S + +L + K+ K A + K +V E+
Sbjct: 856 NVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEK 915
Query: 462 ASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQE 521
+ + + T ++ + L + + +++ + + +E L+++ + +E
Sbjct: 916 LKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLE-STLKKSLEIKEE 974
Query: 522 QVGGTLDAEREVKTR--EQLQAEVQRAQARIEDLEKALAEQ----------GQDMKWIEE 569
++ L+A E T +QL+ E++ + E L++ E+ G+D KW E
Sbjct: 975 KIAA-LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE 1033
Query: 570 KQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEER----ERKSPAI 625
Q R ++ +++ ++E A L+ E Q + Q + LE + L+ + +R++ ++
Sbjct: 1034 SQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSL 1093
Query: 626 SFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQARTVLT 685
+T + LQV E + + + + +L ++L NE + V+ + + +
Sbjct: 1094 QEQNTTLQTQNAKLQV--ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1151
Query: 686 LAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYL---DEELDYRKQALDQANKHILE 742
L + ++ E+ E +R+ + ES L SK G L + L+ + L+ +L+
Sbjct: 1152 LYDSLIKDHEKLELLHERQASEYES---LISKH-GTLKSAHKNLEVEHRDLEDRYNQLLK 1207
Query: 743 LEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQ 802
+ L D L++ + ++L E + + A + L +Q+L+E E+LQ
Sbjct: 1208 QKGQLED-LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE-TEVLQ 1265
Query: 803 LAQQRIKEL-------EERIEAQKRQIKE 824
+ +K L + R+EA+ ++KE
Sbjct: 1266 TDHKNLKSLLNNSKLEQTRLEAEFSKLKE 1294
Score = 95.1 bits (235), Expect = 2e-19
Identities = 194/887 (21%), Positives = 358/887 (40%), Gaps = 149/887 (16%)
Query: 8 SRAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHK 67
+RA+ DK L L+ N L+AKL D+++E ++ K+ ++ E+N L ++ +
Sbjct: 370 TRARSDK---LHELEKENLQLKAKLHDMEMERDMDRKKIEEL-MEENMTLEMAQKQSMDE 425
Query: 68 TAVLLTELKTKLHEEKMKELQAVRETLLRQ-HEAELLRVIKIKDNENQRLQALLSALR-- 124
+ L EL+ ++ E A +++L + +E R++K+ + ENQ L + LR
Sbjct: 426 SLHLGWELEQISRTSELSE--APQKSLGHEVNELTSSRLLKL-EMENQSLTKTVEELRTT 482
Query: 125 ----DGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADK 180
+G K+ + + + + K E+ + ++ QE L+ + ++ + Q +K
Sbjct: 483 VDSVEGNASKI--LKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 181 IKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQ 240
I +++ ER+I+ L +E + ++ V L + + A A+
Sbjct: 541 T---------------IETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA-EARVKD 584
Query: 241 LQKE------ALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARR 294
++KE ++ E S++ + + ++EL H G+ ++ + L EK+
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHL-EKENEL 643
Query: 295 FQLKIAELSAIIRK---LEDRNALLSEERNELLKRVREAES---QYKPLLDKNKRLSRKN 348
Q KI L K LE N+ L E +L K + ++ Q + L +N +L +N
Sbjct: 644 LQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEEN 703
Query: 349 EDLSH---ALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDER-EVDFLKLQI 404
+L +L+ K+ + EN E+ +++ L + ER EV + L I
Sbjct: 704 LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI 763
Query: 405 VEQQNLIDELSKTLETAGYVKSVLERD---------KLLRFRKQRKKMAKLPKPVVVETF 455
Q+ L KTLE + LE + L + ++ K +K + + E
Sbjct: 764 ENQR-----LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818
Query: 456 FGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEE-----GMAKEETELRFRQLTMEYQ 510
E + LE D + + R Q D LEE G ++E + +++ + +
Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878
Query: 511 ALQRAYALLQEQVG----GTLDAEREVKTREQLQAEVQRAQARIEDLEKALAE------- 559
+ R L +E T+D + V RE L +E + Q DLEK E
Sbjct: 879 SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLN 938
Query: 560 --------QGQD---MKWIEEK-QALYRRNQELVE-KIKQMET--EEA-----RLRHEVQ 599
Q D K +E K ++ +++ E+ E KI +E EE+ +LR E++
Sbjct: 939 KERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELK 998
Query: 600 DARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKK 659
+ E L+ R E E + SP IS + E++ T ++ +
Sbjct: 999 TVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWER---------ESQETTRELLKVKDRL 1048
Query: 660 LDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQK 719
+++ +NA L E+Q + Q + + T QI ALQR+ V L+ + Q
Sbjct: 1049 IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI----LALQRQTVSLQEQNTTLQTQN 1104
Query: 720 GYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWK 779
L E L+ + ++ A L +QQ
Sbjct: 1105 AKLQVE----NSTLNSQSTSLMNQNAQLL--IQQ-------------------------- 1132
Query: 780 RQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELE 826
S L + +++ER +L L IK+ E+ +RQ E E
Sbjct: 1133 ----SSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1175
Score = 75.9 bits (185), Expect = 1e-13
Identities = 171/860 (19%), Positives = 356/860 (41%), Gaps = 137/860 (15%)
Query: 14 KAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLT 73
+ E+ L D +AK+ ++ EL+++ ++ + QEL Q+
Sbjct: 242 RTESRQHLSVELADAKAKIRRLRQELEEKTEQL----LDCKQELEQME-----------I 286
Query: 74 ELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVKT 133
ELK +L +E M L R + + E + LR ++ ++
Sbjct: 287 ELK-RLQQENMNLLSDARSARMYRDELDALREKAVRVDK--------------------- 324
Query: 134 VLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRS--VYH 191
L SE ++ ++E K + + ELK + + E T++ D+++ RS ++
Sbjct: 325 -LESEVSRYKERLHDIEFYKAR--VEELKEDNQVLLETKTML--EDQLEGTRARSDKLHE 379
Query: 192 LHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDE--- 248
L +E + K + E+ R M+ K ++ ++E + ++ QK+++DE
Sbjct: 380 LEKENLQLKAKLHDMEMERDMDRKKIEE----LMEENMTLE-------MAQKQSMDESLH 428
Query: 249 ---QLSQVREADRHPGSPRRELPHAAGAGDASD-HSGSPEQQLDEKDARRFQLKIAEL-- 302
+L Q+ +P++ L H +S E Q K + + +
Sbjct: 429 LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG 488
Query: 303 -SAIIRKLEDRNALLSEE----RNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRR 357
++ I K+E N LS++ NE+++ + ++ D K ++ + +
Sbjct: 489 NASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN 548
Query: 358 MENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQD-EREVDFLKLQIVEQQNLIDELSK 416
E ++K + QEN + Q +R+ S ++ + +D E+E L I E + +LSK
Sbjct: 549 SERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSS---KLSK 605
Query: 417 TLETAGYVKSVLE--RDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQ 474
+K LE ++K R + ++ L K E L+ +++
Sbjct: 606 IEFEKRQIKKELEHYKEKGERAEELENELHHLEK-----------ENELLQKKITNLKIT 654
Query: 475 TDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVK 534
++ + + E ++T F+ LT + ++L++ + L E+ L+ R V+
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE---NLELRRNVE 711
Query: 535 TRE-------QLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYR----RNQELVEK 583
+ + QLQ E + ++ E L+K L K E + Y+ NQ L +
Sbjct: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 771
Query: 584 IKQMETEEARLRHEVQDARDQNELLEFRILE-------LEERERKSPAISFHHTPFVDGK 636
++ + +L E+QD +N+ L+ + E LE+ E+++ ++ + K
Sbjct: 772 LENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 637 SPLQ-----VYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWL 691
L+ + +AE + D + E K+ L + N T +++ + + V L
Sbjct: 832 KQLEKENKRLRQQAE-IKDTTLEENNVKIGNL-EKENKTLSKEIGIYKESCVR------L 883
Query: 692 QQIE-ETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALD------QANKHILELE 744
+++E E + ++R +D+ K L + ++ + E+L ++ D + K L E
Sbjct: 884 KELEKENKELVKRATIDI---KTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKE 940
Query: 745 AMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLA 804
+L+D +Q +LL + LK ++E K + ++ L R L E Q
Sbjct: 941 RLLHD--EQSTDDSRYKLLESKLESTLKKSLE-IKEEKIAALEAR----LEESTNYNQQL 993
Query: 805 QQRIKELEERIEAQKRQIKE 824
+Q +K +++ EA K++ E
Sbjct: 994 RQELKTVKKNYEALKQRQDE 1013
Score = 74.3 bits (181), Expect = 4e-13
Identities = 168/846 (19%), Positives = 345/846 (40%), Gaps = 156/846 (18%)
Query: 71 LLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEK 130
++ ++ KL +++ + + + LR H +L V +IK + LQ L+
Sbjct: 51 VMLQINPKLESQRVNK-KVNNDASLRMHNLSIL-VRQIKFYYQETLQQLIMMSLPNVLII 108
Query: 131 VKTVLLSEAKEEAKK------GFEVEKVKMQQEISELKGAKRQVEEALTLVIQA-----D 179
K + EE KK G V+ K ++ I ++G + A+ IQ +
Sbjct: 109 GKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQE 168
Query: 180 KIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRL 239
+ + V + QE+I + K ++RL++E + L E
Sbjct: 169 NVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERD--------- 219
Query: 240 QLQKEALDEQLSQVREADRHPGSPRRELPH--AAGAGDASDHSGSPEQQLDEKDARRFQL 297
L S + PG R E + DA Q+L+EK +
Sbjct: 220 --GLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDC 277
Query: 298 K--IAELSAIIRKLEDRNA-LLSEERNELLKR-----VREAESQYKPLLDKNKRLSRKNE 349
K + ++ +++L+ N LLS+ R+ + R +RE + L + R +
Sbjct: 278 KQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLH 337
Query: 350 DLSHALRRMENKLKFVTQENIEMR-----QRAGIIRRPSSLNDLDQS-----------QD 393
D+ R+E +LK Q +E + Q G R L++L++ +
Sbjct: 338 DIEFYKARVE-ELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEM 396
Query: 394 EREVDFLKLQIVEQQNL-------------------IDELSKTLETA-------GYVKSV 427
ER++D K++ + ++N+ ++++S+T E + G+ +
Sbjct: 397 ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNE 456
Query: 428 LERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDD 487
L +LL+ + + + K V E D S+E + S + + ++ +Q +
Sbjct: 457 LTSSRLLKLEMENQSLTK----TVEELRTTVD---SVEGNASKI-LKMEKENQRLSKKVE 508
Query: 488 DLEEGMAKEETELR-----FRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAE 542
LE + +E+ L+ + L E L++ L+E ++ER++K EQ
Sbjct: 509 ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE------NSERQIKILEQENEH 562
Query: 543 VQR------------AQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETE 590
+ + A+AR++D+EK E + L+ +E K+ ++E E
Sbjct: 563 LNQTVSSLRQRSQISAEARVKDIEK-------------ENKILHESIKETSSKLSKIEFE 609
Query: 591 EARLRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTD 650
+ +++ E++ +++ E E EL E+++ + T L++ CE +
Sbjct: 610 KRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN-------LKITCEKIEALE 662
Query: 651 IVVAEL----MKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMV 706
+EL K L NLT + L EK Q++E L+R +
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQ-----------LESLEKENSQLDEENLELRRNVE 711
Query: 707 DLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEE 766
L+ + Q ++EL+ K+ L + LEL L + ++ +V+ +
Sbjct: 712 SLKCASMKMA-QLQLENKELESEKEQLKKG----LEL---LKASFKKTERLEVSYQGLDI 763
Query: 767 EREKLKVAVEQWKRQVM---SELR--ERDAQILRERMELLQLAQQRIKELEERIEAQKRQ 821
E ++L+ +E +++ SEL+ E + Q L++ +E L+++ +R+++LE+ ++ +++
Sbjct: 764 ENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQE 823
Query: 822 IKELEE 827
+LE+
Sbjct: 824 TSQLEK 829
Score = 66.6 bits (161), Expect = 9e-11
Identities = 125/533 (23%), Positives = 208/533 (39%), Gaps = 95/533 (17%)
Query: 316 LSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQR 375
LSEER+ L + S P + + + LS L + K++ + QE E ++
Sbjct: 214 LSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQ 273
Query: 376 AGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKLLR 435
L D Q ++ E++ +LQ E NL+ + + RD+L
Sbjct: 274 ---------LLDCKQELEQMEIELKRLQ-QENMNLLSDARSAR---------MYRDELDA 314
Query: 436 FRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAK 495
R++ ++ KL S VS +R D+E A+
Sbjct: 315 LREKAVRVDKLE---------------------SEVSRYKERLH--------DIEFYKAR 345
Query: 496 EETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEK 555
E +L + Q L +L++Q+ GT R K E L+ E + +A++ D+E
Sbjct: 346 VE------ELKEDNQVLLETKTMLEDQLEGT--RARSDKLHE-LEKENLQLKAKLHDMEM 396
Query: 556 ALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILEL 615
E+ D K IEE L N L KQ E L E++ R EL
Sbjct: 397 ---ERDMDRKKIEE---LMEENMTLEMAQKQSMDESLHLGWELEQIS--------RTSEL 442
Query: 616 EERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQV 675
E +KS H + L++ E + +T V EL +D + NA+ + +
Sbjct: 443 SEAPQKSLG---HEVNELTSSRLLKLEMENQSLTK-TVEELRTTVDSVEGNASKILKMEK 498
Query: 676 VVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQ 735
+ + + E + Q +++ Q DL EK K L E + + + L+Q
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558
Query: 736 ANKHILELEAMLYDALQQEAGAKVAELLSEEE--REKLKVA------VEQWKRQVMSELR 787
N+H+ + + L Q A A+V ++ E + E +K +E KRQ+ EL
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 788 ------------ERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEK 828
E + L + ELLQ +K E+IEA +++ ELE +
Sbjct: 619 HYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 104 bits (259), Expect = 4e-22
Identities = 183/837 (21%), Positives = 351/837 (41%), Gaps = 151/837 (18%)
Query: 63 HEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSA 122
H H+ +L +++ + M +LQA + L Q E +LLR K D ++ +L + +++
Sbjct: 130 HHHHQVPSMLRQVR----DSTMLDLQAQLKEL--QRENDLLR--KELDIKDSKLGSSMNS 181
Query: 123 LRD-GGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKI 181
++ PE K +L KEEA + + +K Q +S + + L L IQA +
Sbjct: 182 IKTFWSPELKKERVLR--KEEAAR---MSVLKEQMRVSH------EENQHLQLTIQALQD 230
Query: 182 KAAEIRSVYHLHQEEITRIKKE------CEREIRRLMEEIKFKDRAVFVLERELGVQAGH 235
+ R + HL Q+E E E RRL E + + +F+L + L
Sbjct: 231 ELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEME-- 288
Query: 236 AQRLQLQKEAL---DEQLSQVREADRHPGSPRRELP----HAAGAGDASDHSGSPEQQLD 288
R++ QK+ L DE + ++ E + G P + L +A E LD
Sbjct: 289 -LRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILD 347
Query: 289 EKDA----------RRFQL-------------------KIAELSAIIRKLEDRNALL--- 316
+K+ RR QL KIA L IR LED +L
Sbjct: 348 QKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKAN 407
Query: 317 ----SEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEM 372
+E+R E +K++ +S K + K +L ++ L ++ KL+ ++ +N +
Sbjct: 408 GVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDC 467
Query: 373 RQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLE--- 429
+Q +++ + + + + EVD L+L++ E+++ +++ +K L+ K L
Sbjct: 468 KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEI 527
Query: 430 RDKLLRFRKQRKKMAKLPKPV--VVETFFGYDEE-ASLESDGSSVSYQTDRTDQTPCTPD 486
RD + +K+ L K + + E D++ +L+ S+ + TD T +
Sbjct: 528 RDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLE 587
Query: 487 DDLEEG-----MAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQA 541
+ L E KE+ E R+ E ++ ++ L+E+V L AE K +
Sbjct: 588 EALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNA-LQAELTEKESSLIDL 646
Query: 542 EVQ---------RAQARIEDLEKALAEQGQDMKWIEEK-------QALYRRNQELVEKIK 585
+ + ++++ LE A+ ++ ++ +E + + R N E ++IK
Sbjct: 647 KEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIK 706
Query: 586 QMETEEARLRHEVQDARDQNELLEFRILELE-ERERKSPAISFHHTPFVDGKSPLQVYCE 644
Q++ E + R E A+ + + L + E+E E+ K I+ E
Sbjct: 707 QLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIA-----------------E 749
Query: 645 AEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRK 704
E +T + + KK+ L N L ++ + L+++ E ++
Sbjct: 750 LESLTLRHMKDQNKKVANLKHNQQLEKKKNA-------------QLLEEVRRREDSMADN 796
Query: 705 MVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLS 764
L+ E+ + + +K +ELD K L + + E EA L + L
Sbjct: 797 SQHLQIEELMNALEK--TRQELDATKARLASTQQSLAEKEAHLAN-------------LR 841
Query: 765 EEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQ 821
E R++L+ +E + +++ + E+DA I LL+L+ + K+ +E + A KR+
Sbjct: 842 IERRKQLEEILEMKQEALLAAISEKDANI-----ALLELSASKKKKTQEEVMALKRE 893
Score = 66.6 bits (161), Expect = 9e-11
Identities = 108/547 (19%), Positives = 243/547 (44%), Gaps = 64/547 (11%)
Query: 301 ELSAIIRKLEDRNALLSEERN----ELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALR 356
+L A +++L+ N LL +E + +L + ++ + P L K +R+ RK E ++
Sbjct: 149 DLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPEL-KKERVLRKEEAARMSVL 207
Query: 357 RMENKLKFVTQENIEMRQRA--GIIRRPSSLNDL-DQSQDEREVDFLKLQIVEQ--QNLI 411
+ + ++ +++++ +A +R LN L Q R + +++ E+ + L
Sbjct: 208 KEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQ 267
Query: 412 DELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSV 471
E + + ++ LE +L R + +K + ++ + L S S+
Sbjct: 268 AEHDRQAKELFLLRKTLEEMEL---RIETQKQTLNARDESIKKLLEMLQSKGLPS--KSL 322
Query: 472 SYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAER 531
+RT + MA+ E+++ ++ ++ + + + L+E++ +
Sbjct: 323 EDDNERTRR------------MAEAESQVSHLEVILDQKEKENIH--LREELHRRSQLQP 368
Query: 532 EVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEE 591
E + LQ ++ +I LE+ + + +++ ++ L ++E E+IKQ+E +
Sbjct: 369 EPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDRE--EEIKQIEVYK 426
Query: 592 ARLRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDI 651
+ + + L + EL + K +S ++ D K ++V E+ +
Sbjct: 427 SHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNS---DCKQHIEVLKESLTAKEQ 483
Query: 652 VVAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESE 711
A L ++D L L EE+ + +T K LQ + E + L ++ D++
Sbjct: 484 RAAILQTEVDAL----RLRLEEKESFLNKKT------KQLQDLTEEKGTLAGEIRDMKDM 533
Query: 712 KELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAG------AKVAELLSE 765
E+ ++ L ++++ ++ L +K + L+ + +LQ ++ A + E LSE
Sbjct: 534 LEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRV-KSLQTDSSNTDTALATLEEALSE 592
Query: 766 EEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKEL 825
+ER +E+ K Q RERD RER+E ++ ++ K+L+E++ A + ++ E
Sbjct: 593 KER-----IIERLKEQ-----RERDD---RERLEEIESFRKENKDLKEKVNALQAELTEK 639
Query: 826 EEKFLFL 832
E + L
Sbjct: 640 ESSLIDL 646
Score = 38.9 bits (89), Expect = 0.020
Identities = 55/314 (17%), Positives = 126/314 (40%), Gaps = 42/314 (13%)
Query: 13 DKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELR---QVREHEQHKTA 69
D E ++L +A +KL ++I ++Q+K + SK+E + + R + +
Sbjct: 645 DLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQ 704
Query: 70 VLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSAL----RD 125
+ + + + ++ + QA + LL E+L+ ++ + N+ + A L +L
Sbjct: 705 IKQLDKEASYYRDECGKAQAEVDRLL-----EILKEVENEKNDKDKKIAELESLTLRHMK 759
Query: 126 GGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLV------IQAD 179
+KV + ++ E+ K +E+V+ +++ Q+EE + + + A
Sbjct: 760 DQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDAT 819
Query: 180 KIKAAEIRSVYHLHQEEITRIKKECEREIRRLME--------EIKFKDRAVFVLERELGV 231
K + A + + + ++ E +++ ++E I KD + +LE
Sbjct: 820 KARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASK 879
Query: 232 QAGHAQRLQLQKEALDEQLSQVRE---------ADRHPGSPRRELPH-------AAGAGD 275
+ + + K D + Q+++ AD + H + G
Sbjct: 880 KKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMADNYDDDHHHYHHHHHHHHHRSPGRSQ 939
Query: 276 ASDHSGSPEQQLDE 289
S+H SP+Q +E
Sbjct: 940 HSNHRPSPDQDDEE 953
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 103 bits (257), Expect = 7e-22
Identities = 190/884 (21%), Positives = 369/884 (41%), Gaps = 125/884 (14%)
Query: 13 DKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
D E +A LQA +L+ +L + ELQ +++ +KN L+++RE E H +
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH-----I 1120
Query: 73 TELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVK 132
++L+ L E+ +A ++ E E L+ ++ Q L A R+ +
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE-----QE 1175
Query: 133 TVLLSEAKEEAKKGFEVEKVKMQQ-----------EISELKGAKRQVEEALTLVIQADKI 181
+L +A +E + E + +M+Q ++ + K AK +++ + + +
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235
Query: 182 KAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRA-------VFVLERE------ 228
A E+R V ++E+ KK+ E +++ L + +RA V L+ E
Sbjct: 1236 LAGELR-VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294
Query: 229 -LGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQL 287
L G A +L +L QL +E + R++L + + S + QL
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQE--ETRQKLNVSTKLRQLEEERNSLQDQL 1352
Query: 288 DEKDARRFQL----------------KIAELSAIIRKLEDRNALLSEERNELLKRVREAE 331
DE+ + L K+ + ++ + LE+ +E L ++ E
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 332 SQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQS 391
+ Y L RL ++ +DL + ++N+ + V+ N+E +QR N +
Sbjct: 1413 AAYDKLEKTKNRLQQELDDL---VVDLDNQRQLVS--NLEKKQRKFDQLLAEEKNISSKY 1467
Query: 392 QDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLER-DKLLRFRKQRKKMAKLPKPV 450
DER D + + E++ L++ LE A K LER +K+L+ A++ V
Sbjct: 1468 ADER--DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK--------AEMEDLV 1517
Query: 451 VVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQ 510
+ G + LE ++ Q + +D+L+ A E+ +LR L + Q
Sbjct: 1518 SSKDDVGKNVH-ELEKSKRALETQMEEMKTQLEELEDELQ---ATEDAKLR---LEVNMQ 1570
Query: 511 ALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIED--LEKALAEQGQ-----D 563
AL+ + E+ D + E K R QLQ ++ + +ED ++ALA + D
Sbjct: 1571 ALKGQF----ERDLQARDEQNEEK-RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625
Query: 564 MKWIE-EKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKS 622
+K +E + + + +E ++++++++ + + E++DAR + + +E E+K+
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI---FATAKENEKKA 1682
Query: 623 PAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQART 682
++ + + L A D+ EL ++L N +E+
Sbjct: 1683 KSL---EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK-------- 1731
Query: 683 VLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEEL----------DYRKQA 732
E + Q+EE Q M + ++Q L EL + +Q
Sbjct: 1732 --RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1789
Query: 733 LDQANKHIL----ELEAMLYDALQQEAG---AKVAELLSEEERE-KLKVAVEQWKRQVMS 784
L++ NK + E+E + + AK+A+L + E+E + K A + +Q
Sbjct: 1790 LERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849
Query: 785 ELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEK 828
+L+E Q+ ER Q +Q K R++ KRQ++E EE+
Sbjct: 1850 KLKEILLQVEDERKMAEQYKEQAEKG-NARVKQLKRQLEEAEEE 1892
Score = 99.4 bits (246), Expect = 1e-20
Identities = 194/907 (21%), Positives = 376/907 (41%), Gaps = 171/907 (18%)
Query: 35 IQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLTELKTKLHEEKMKELQAVRETL 94
+Q+ Q+E+ + + E +K +E +Q E+E L EL+ K H + +E ++E L
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENE-------LKELEQK-HSQLTEEKNLLQEQL 896
Query: 95 LRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKG--FEVEKV 152
Q E EL E + ++ L+A + E++ + + +EE +G + E+
Sbjct: 897 --QAETELYA-------EAEEMRVRLAAKKQ-ELEEILHEMEARLEEEEDRGQQLQAERK 946
Query: 153 KMQQEISELKGAKRQVEEALTLVIQADKIKA-AEIRSVYHLHQEEITRIKKECEREIRRL 211
KM Q++ +L+ + + EEA +Q +K+ A A+I+ + ++EI + + + +L
Sbjct: 947 KMAQQMLDLE-EQLEEEEAARQKLQLEKVTAEAKIKKL----EDEILVM----DDQNNKL 997
Query: 212 MEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAA 271
+E K + + L L + A+ L K + +S++ + R+EL
Sbjct: 998 SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK 1057
Query: 272 G--AGDASDHSGSPEQQLDEKDARRFQLKI------AELSAIIRKLEDRNALLSEERNEL 323
GDASD +Q+ + A+ +LK+ EL A + +L+D A ++N
Sbjct: 1058 RKLEGDASDF----HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA----QKNNA 1109
Query: 324 LKRVREAESQYKPL---LDKNKRLSRKNE----DLSHALRRMENKLK-----FVTQENIE 371
LK++RE E L LD + K E DL L ++ +L+ TQ+ +
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1169
Query: 372 MRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERD 431
++ + +L++ +S + + + + + ++EL++ LE K+ L+++
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQ----KHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 432 K---------------LLRFRKQ-----RKKMAKLPKPVVVETFFGYDEEASL------- 464
K +L KQ +KK+ + + + G A L
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 465 ------------ESDGSSVSYQTD---RTDQTPCTPDDDLEEGMAKEETELRFRQLTMEY 509
E++G ++ D + Q T + EE K + RQL E
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 510 QALQRAYALLQEQVGGTLDAEREVKTR------------------EQLQAEVQRAQARIE 551
+LQ L E++ + ER + T E L+ +R Q IE
Sbjct: 1346 NSLQDQ---LDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 552 DLEKALAEQGQDMKWIEE-KQALYRRNQELV-----------------EKIKQMETEEAR 593
+L + E+ +E+ K L + +LV K Q+ EE
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 594 LRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVV 653
+ + D RD+ E E RE+++ A+S + L+ E E ++
Sbjct: 1463 ISSKYADERDR--------AEAEAREKETKALSLARAL----EEALEAKEELERTNKMLK 1510
Query: 654 AE---LMKKLDILGDNAN-LTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLE 709
AE L+ D +G N + L ++ + Q + T E+ +++ TE A R V+++
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570
Query: 710 SEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEERE 769
+ K F + DE+ + +++ Q + + E E L D +Q A A A+ E + +
Sbjct: 1571 ALKGQFERDLQARDEQNEEKRR---QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK 1627
Query: 770 KLKVAVE---QWKRQVMSELRERDAQILRERMELLQLAQQR------IKELEERIEAQKR 820
L++ + + + + + +LR+ AQ+ + EL R KE E++ ++ +
Sbjct: 1628 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1687
Query: 821 QIKELEE 827
+ +L+E
Sbjct: 1688 DLMQLQE 1694
Score = 79.3 bits (194), Expect = 1e-14
Identities = 157/771 (20%), Positives = 339/771 (43%), Gaps = 113/771 (14%)
Query: 115 RLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALT- 173
+++ LL R + K L + KE +K E E +++Q+ S+L K ++E L
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 174 ---LVIQADKIK---AAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLER 227
L +A++++ AA+ + + + E R+++E +R ++L E K + + LE
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG-QQLQAERKKMAQQMLDLEE 957
Query: 228 ELGVQAGHAQRLQLQKEALDEQLSQ------VREADRHPGSPRRELPHAAGAGDASDHSG 281
+L + Q+LQL+K + ++ + V + + S R+L D + +
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER-ISDLTTNLA 1016
Query: 282 SPEQQLDE--KDARRFQLKIAELSAIIRK-------LEDRNALLSEERNELLKRVREAES 332
E++ K + + I+EL ++K LE L + ++ +++ + ++
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 333 QYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQ 392
Q + + +L++K E+L AL R++++ + Q+N +++ I ++DL +
Sbjct: 1077 Q---IAELKMQLAKKEEELQAALARLDDE---IAQKNNALKK---IRELEGHISDLQEDL 1127
Query: 393 DEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVV 452
D K + ++++L +EL +K+ LE D L Q++ AK + V V
Sbjct: 1128 DSERAARNKAE-KQKRDLGEELEA-------LKTELE-DTLDSTATQQELRAKREQEVTV 1178
Query: 453 ETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQAL 512
+ +L+ + S Q Q ++L E + E+ + L Q L
Sbjct: 1179 -------LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL--EQFKRAKANLDKNKQTL 1229
Query: 513 QRAYALLQEQVGGTLDAEREVK-TREQLQAEVQRAQARIEDLEKALAE------------ 559
++ A L ++ A++EV+ +++L+A+VQ Q++ D E+A AE
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Query: 560 ----------QGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLE 609
+G+ +K ++ +L + Q+ E +++ ++ + +++ ++ L+
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349
Query: 610 FRI-LELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNAN 668
++ E+E ++ IS + D K LQ + T + E K+ +N
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS----TVEALEEGKKRFQKEIENLT 1405
Query: 669 LTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKM----VDLESEKELFSKQKGYLDE 724
EE+ ++E+T+ LQ+++ VDL+++++L S
Sbjct: 1406 QQYEEKAAA-------------YDKLEKTKNRLQQELDDLVVDLDNQRQLVS-------- 1444
Query: 725 ELDYRKQALDQ---ANKHILELEAMLYDALQQEAGAKVAELLS----EEEREKLKVAVEQ 777
L+ +++ DQ K+I A D + EA K + LS EE + K +E+
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1504
Query: 778 WKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEK 828
+ + +E+ + + + +L + + + LE ++E K Q++ELE++
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSK-RALETQMEEMKTQLEELEDE 1554
Score = 72.4 bits (176), Expect = 2e-12
Identities = 138/654 (21%), Positives = 266/654 (40%), Gaps = 81/654 (12%)
Query: 26 EDLRAKLTDIQIELQQEKSKVSKVEREKN-------QELRQVREHEQHKTAVLLTELKTK 78
E RA+L D +LQ E V+ + E +++ + Q +L E + K
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 79 LH-EEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVKTVLLS 137
L+ K+++L+ R +L Q + E+ + K N + + L L D +
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEM----EAKQNLERHISTLNIQLSDSKKKLQDFASTV 1387
Query: 138 EAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEI 197
EA EE KK F+ E + Q+ E A ++E+ + Q ++ + L +
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL----V 1443
Query: 198 TRIKKECEREIRRLMEEIKFKDRAVFVLER-ELGVQAGHAQRLQLQKEALDEQLSQVREA 256
+ ++K+ + + L EE + +R E + + L L + AL+E L E
Sbjct: 1444 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR-ALEEALEAKEEL 1502
Query: 257 DRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALL 316
+R + E+ + D G +L EK R + ++ E+ + +LED
Sbjct: 1503 ERTNKMLKAEMEDLVSS---KDDVGKNVHEL-EKSKRALETQMEEMKTQLEELEDELQAT 1558
Query: 317 SEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRA 376
+ + L ++ + Q++ L +NE+ L+R ++ + ++ + R A
Sbjct: 1559 EDAKLRLEVNMQALKGQFERDLQAR---DEQNEEKRRQLQRQLHEYETELEDERKQRALA 1615
Query: 377 GIIRRP--SSLNDLDQSQDE----REVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLER 430
++ L DL+ D RE +L+ ++ Q + + + LE A R
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ--MKDFQRELEDAR-----ASR 1668
Query: 431 DKLLRFRKQRKKMAKLPKPVVVETF------------FGYDEEASLESDGSSVSYQTDRT 478
D++ K+ +K AK + +++ ++E E SS+S +
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1728
Query: 479 DQTPCTPDDDLEEGMAKEETELRFRQLTMEY------QALQRAYALLQEQVGGTLDAERE 532
D+ LE +A+ E EL Q ME +A Q+A L E A++
Sbjct: 1729 DEKR-----RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783
Query: 533 VKTREQLQAEVQRAQARIEDLEKAL------------AEQGQDMKWIE----EKQA---- 572
R+QL+ + + ++++ ++E A+ A+ Q + +E EKQA
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 573 LYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAIS 626
L +++++L E + Q+E E + A N ++ +LEE E +S I+
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897
Score = 63.2 bits (152), Expect = 1e-09
Identities = 78/435 (17%), Positives = 188/435 (43%), Gaps = 60/435 (13%)
Query: 20 ALQAANEDLRAKLTDIQIELQQEKSKVSKVE---------------------REKNQEL- 57
AL+ E+++ +L +++ ELQ + ++E EK ++L
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 58 RQVREHE-----QHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNE 112
RQ+ E+E + K L K KL E +K+L+ ++ ++ E + ++ K++
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKL-EGDLKDLELQADSAIKGREEAIKQLRKLQ--- 1651
Query: 113 NQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVE--- 169
+++ L D + + ++ E+ K E + +++Q++++ + A++Q +
Sbjct: 1652 -AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710
Query: 170 EALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECERE---IRRLMEEIKFKDRAVFVLE 226
E L + + ++ + I ++++E E E + + + ++ + L
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770
Query: 227 RELGVQAGHAQRLQLQKEALDEQLSQVR-EADRHPGSPRRELPHAAGAGDA--SDHSGSP 283
EL + AQ+ + ++ L+ Q ++R + G+ + + A +A +
Sbjct: 1771 NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1830
Query: 284 EQQLDEKDARRFQLKIAE--LSAIIRKLEDRNALLSEERNE----------LLKRVREAE 331
EQ+ EK A LK + L I+ ++ED + + + + L +++ EAE
Sbjct: 1831 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE 1890
Query: 332 SQYKPLLDKNKRLSRK-------NEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSS 384
+ + + ++L R+ NE + + +++KL+ + + +R+G R +
Sbjct: 1891 EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIEN 1950
Query: 385 LNDLDQSQDEREVDF 399
+ ++ D R+ DF
Sbjct: 1951 ADGSEEETDTRDADF 1965
Score = 52.4 bits (124), Expect = 2e-06
Identities = 84/386 (21%), Positives = 175/386 (45%), Gaps = 63/386 (16%)
Query: 495 KEETELRFRQLTMEYQAL------QRAYALLQEQVGGTLDAER----------------- 531
+EE +L+ + M +QA+ ++A+A Q+Q+ +R
Sbjct: 779 EEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLF 838
Query: 532 -EVKTREQLQAEVQRAQARIEDLEKALAEQGQ---DMKWIEEKQALYRRNQELVEKIKQM 587
+VK Q+ + + QA+ ++L+K Q + ++K +E+K + + L+++ Q
Sbjct: 839 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 588 ET------EEARLRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQV 641
ET EE R+R + ++ E+L LEE E + + L+
Sbjct: 899 ETELYAEAEEMRVRLAAK-KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 642 YCEAEGVT------DIVVAEL-MKKLD----ILGDNANLTNEEQVVVIQARTVLT--LAE 688
E E + V AE +KKL+ ++ D N ++E+ ++ + + LT LAE
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 689 KWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALD----QANKHILELE 744
+ ++ + L+ K + SE E+ K++ +EL+ K+ L+ ++ I +L+
Sbjct: 1018 E--EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQ 1075
Query: 745 AMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQI--LRERMELLQ 802
A + + L+ + K EL + R ++A K + ++RE + I L+E ++ +
Sbjct: 1076 AQIAE-LKMQLAKKEEELQAALARLDDEIA---QKNNALKKIRELEGHISDLQEDLDSER 1131
Query: 803 LAQQRI----KELEERIEAQKRQIKE 824
A+ + ++L E +EA K ++++
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELED 1157
Score = 35.0 bits (79), Expect = 0.29
Identities = 34/144 (23%), Positives = 65/144 (45%), Gaps = 30/144 (20%)
Query: 689 KWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLY 748
K L Q+ E +Q K +L+ KE K + L E L+Q + + E + +L
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKE--------LEQKHSQLTEEKNLLQ 893
Query: 749 DALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRI 808
+ LQ E EL +E E ++++A ++ +E E+L + R+
Sbjct: 894 EQLQAET-----ELYAEAEEMRVRLAAKK-----------------QELEEILHEMEARL 931
Query: 809 KELEERIEAQKRQIKELEEKFLFL 832
+E E+R + + + K++ ++ L L
Sbjct: 932 EEEEDRGQQLQAERKKMAQQMLDL 955
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 103 bits (257), Expect = 7e-22
Identities = 190/884 (21%), Positives = 369/884 (41%), Gaps = 125/884 (14%)
Query: 13 DKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
D E +A LQA +L+ +L + ELQ +++ +KN L+++RE E H +
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH-----I 1127
Query: 73 TELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVK 132
++L+ L E+ +A ++ E E L+ ++ Q L A R+ +
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE-----QE 1182
Query: 133 TVLLSEAKEEAKKGFEVEKVKMQQ-----------EISELKGAKRQVEEALTLVIQADKI 181
+L +A +E + E + +M+Q ++ + K AK +++ + + +
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242
Query: 182 KAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRA-------VFVLERE------ 228
A E+R V ++E+ KK+ E +++ L + +RA V L+ E
Sbjct: 1243 LAGELR-VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301
Query: 229 -LGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQL 287
L G A +L +L QL +E + R++L + + S + QL
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQE--ETRQKLNVSTKLRQLEEERNSLQDQL 1359
Query: 288 DEKDARRFQL----------------KIAELSAIIRKLEDRNALLSEERNELLKRVREAE 331
DE+ + L K+ + ++ + LE+ +E L ++ E
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 332 SQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQS 391
+ Y L RL ++ +DL + ++N+ + V+ N+E +QR N +
Sbjct: 1420 AAYDKLEKTKNRLQQELDDL---VVDLDNQRQLVS--NLEKKQRKFDQLLAEEKNISSKY 1474
Query: 392 QDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLER-DKLLRFRKQRKKMAKLPKPV 450
DER D + + E++ L++ LE A K LER +K+L+ A++ V
Sbjct: 1475 ADER--DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK--------AEMEDLV 1524
Query: 451 VVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQ 510
+ G + LE ++ Q + +D+L+ A E+ +LR L + Q
Sbjct: 1525 SSKDDVGKNVH-ELEKSKRALETQMEEMKTQLEELEDELQ---ATEDAKLR---LEVNMQ 1577
Query: 511 ALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIED--LEKALAEQGQ-----D 563
AL+ + E+ D + E K R QLQ ++ + +ED ++ALA + D
Sbjct: 1578 ALKGQF----ERDLQARDEQNEEK-RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632
Query: 564 MKWIE-EKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKS 622
+K +E + + + +E ++++++++ + + E++DAR + + +E E+K+
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI---FATAKENEKKA 1689
Query: 623 PAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQART 682
++ + + L A D+ EL ++L N +E+
Sbjct: 1690 KSL---EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK-------- 1738
Query: 683 VLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEEL----------DYRKQA 732
E + Q+EE Q M + ++Q L EL + +Q
Sbjct: 1739 --RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1796
Query: 733 LDQANKHIL----ELEAMLYDALQQEAG---AKVAELLSEEERE-KLKVAVEQWKRQVMS 784
L++ NK + E+E + + AK+A+L + E+E + K A + +Q
Sbjct: 1797 LERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856
Query: 785 ELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEK 828
+L+E Q+ ER Q +Q K R++ KRQ++E EE+
Sbjct: 1857 KLKEILLQVEDERKMAEQYKEQAEKG-NARVKQLKRQLEEAEEE 1899
Score = 99.4 bits (246), Expect = 1e-20
Identities = 194/907 (21%), Positives = 376/907 (41%), Gaps = 171/907 (18%)
Query: 35 IQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLTELKTKLHEEKMKELQAVRETL 94
+Q+ Q+E+ + + E +K +E +Q E+E L EL+ K H + +E ++E L
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENE-------LKELEQK-HSQLTEEKNLLQEQL 903
Query: 95 LRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKG--FEVEKV 152
Q E EL E + ++ L+A + E++ + + +EE +G + E+
Sbjct: 904 --QAETELYA-------EAEEMRVRLAAKKQ-ELEEILHEMEARLEEEEDRGQQLQAERK 953
Query: 153 KMQQEISELKGAKRQVEEALTLVIQADKIKA-AEIRSVYHLHQEEITRIKKECEREIRRL 211
KM Q++ +L+ + + EEA +Q +K+ A A+I+ + ++EI + + + +L
Sbjct: 954 KMAQQMLDLE-EQLEEEEAARQKLQLEKVTAEAKIKKL----EDEILVM----DDQNNKL 1004
Query: 212 MEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAA 271
+E K + + L L + A+ L K + +S++ + R+EL
Sbjct: 1005 SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK 1064
Query: 272 G--AGDASDHSGSPEQQLDEKDARRFQLKI------AELSAIIRKLEDRNALLSEERNEL 323
GDASD +Q+ + A+ +LK+ EL A + +L+D A ++N
Sbjct: 1065 RKLEGDASDF----HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA----QKNNA 1116
Query: 324 LKRVREAESQYKPL---LDKNKRLSRKNE----DLSHALRRMENKLK-----FVTQENIE 371
LK++RE E L LD + K E DL L ++ +L+ TQ+ +
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1176
Query: 372 MRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERD 431
++ + +L++ +S + + + + + ++EL++ LE K+ L+++
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQ----KHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 432 K---------------LLRFRKQ-----RKKMAKLPKPVVVETFFGYDEEASL------- 464
K +L KQ +KK+ + + + G A L
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 465 ------------ESDGSSVSYQTD---RTDQTPCTPDDDLEEGMAKEETELRFRQLTMEY 509
E++G ++ D + Q T + EE K + RQL E
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 510 QALQRAYALLQEQVGGTLDAEREVKTR------------------EQLQAEVQRAQARIE 551
+LQ L E++ + ER + T E L+ +R Q IE
Sbjct: 1353 NSLQDQ---LDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 552 DLEKALAEQGQDMKWIEE-KQALYRRNQELV-----------------EKIKQMETEEAR 593
+L + E+ +E+ K L + +LV K Q+ EE
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 594 LRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVV 653
+ + D RD+ E E RE+++ A+S + L+ E E ++
Sbjct: 1470 ISSKYADERDR--------AEAEAREKETKALSLARAL----EEALEAKEELERTNKMLK 1517
Query: 654 AE---LMKKLDILGDNAN-LTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLE 709
AE L+ D +G N + L ++ + Q + T E+ +++ TE A R V+++
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577
Query: 710 SEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEERE 769
+ K F + DE+ + +++ Q + + E E L D +Q A A A+ E + +
Sbjct: 1578 ALKGQFERDLQARDEQNEEKRR---QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK 1634
Query: 770 KLKVAVE---QWKRQVMSELRERDAQILRERMELLQLAQQR------IKELEERIEAQKR 820
L++ + + + + + +LR+ AQ+ + EL R KE E++ ++ +
Sbjct: 1635 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1694
Query: 821 QIKELEE 827
+ +L+E
Sbjct: 1695 DLMQLQE 1701
Score = 79.3 bits (194), Expect = 1e-14
Identities = 157/771 (20%), Positives = 339/771 (43%), Gaps = 113/771 (14%)
Query: 115 RLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALT- 173
+++ LL R + K L + KE +K E E +++Q+ S+L K ++E L
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 174 ---LVIQADKIK---AAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLER 227
L +A++++ AA+ + + + E R+++E +R ++L E K + + LE
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG-QQLQAERKKMAQQMLDLEE 964
Query: 228 ELGVQAGHAQRLQLQKEALDEQLSQ------VREADRHPGSPRRELPHAAGAGDASDHSG 281
+L + Q+LQL+K + ++ + V + + S R+L D + +
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER-ISDLTTNLA 1023
Query: 282 SPEQQLDE--KDARRFQLKIAELSAIIRK-------LEDRNALLSEERNELLKRVREAES 332
E++ K + + I+EL ++K LE L + ++ +++ + ++
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 333 QYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQ 392
Q + + +L++K E+L AL R++++ + Q+N +++ I ++DL +
Sbjct: 1084 Q---IAELKMQLAKKEEELQAALARLDDE---IAQKNNALKK---IRELEGHISDLQEDL 1134
Query: 393 DEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVV 452
D K + ++++L +EL +K+ LE D L Q++ AK + V V
Sbjct: 1135 DSERAARNKAE-KQKRDLGEELEA-------LKTELE-DTLDSTATQQELRAKREQEVTV 1185
Query: 453 ETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQAL 512
+ +L+ + S Q Q ++L E + E+ + L Q L
Sbjct: 1186 -------LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL--EQFKRAKANLDKNKQTL 1236
Query: 513 QRAYALLQEQVGGTLDAEREVK-TREQLQAEVQRAQARIEDLEKALAE------------ 559
++ A L ++ A++EV+ +++L+A+VQ Q++ D E+A AE
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296
Query: 560 ----------QGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLE 609
+G+ +K ++ +L + Q+ E +++ ++ + +++ ++ L+
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356
Query: 610 FRI-LELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNAN 668
++ E+E ++ IS + D K LQ + T + E K+ +N
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS----TVEALEEGKKRFQKEIENLT 1412
Query: 669 LTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKM----VDLESEKELFSKQKGYLDE 724
EE+ ++E+T+ LQ+++ VDL+++++L S
Sbjct: 1413 QQYEEKAAA-------------YDKLEKTKNRLQQELDDLVVDLDNQRQLVS-------- 1451
Query: 725 ELDYRKQALDQ---ANKHILELEAMLYDALQQEAGAKVAELLS----EEEREKLKVAVEQ 777
L+ +++ DQ K+I A D + EA K + LS EE + K +E+
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1511
Query: 778 WKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEK 828
+ + +E+ + + + +L + + + LE ++E K Q++ELE++
Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHELEKSK-RALETQMEEMKTQLEELEDE 1561
Score = 72.4 bits (176), Expect = 2e-12
Identities = 138/654 (21%), Positives = 266/654 (40%), Gaps = 81/654 (12%)
Query: 26 EDLRAKLTDIQIELQQEKSKVSKVEREKN-------QELRQVREHEQHKTAVLLTELKTK 78
E RA+L D +LQ E V+ + E +++ + Q +L E + K
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 79 LH-EEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVKTVLLS 137
L+ K+++L+ R +L Q + E+ + K N + + L L D +
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEM----EAKQNLERHISTLNIQLSDSKKKLQDFASTV 1394
Query: 138 EAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEI 197
EA EE KK F+ E + Q+ E A ++E+ + Q ++ + L +
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL----V 1450
Query: 198 TRIKKECEREIRRLMEEIKFKDRAVFVLER-ELGVQAGHAQRLQLQKEALDEQLSQVREA 256
+ ++K+ + + L EE + +R E + + L L + AL+E L E
Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR-ALEEALEAKEEL 1509
Query: 257 DRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALL 316
+R + E+ + D G +L EK R + ++ E+ + +LED
Sbjct: 1510 ERTNKMLKAEMEDLVSS---KDDVGKNVHEL-EKSKRALETQMEEMKTQLEELEDELQAT 1565
Query: 317 SEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRA 376
+ + L ++ + Q++ L +NE+ L+R ++ + ++ + R A
Sbjct: 1566 EDAKLRLEVNMQALKGQFERDLQAR---DEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622
Query: 377 GIIRRP--SSLNDLDQSQDE----REVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLER 430
++ L DL+ D RE +L+ ++ Q + + + LE A R
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ--MKDFQRELEDAR-----ASR 1675
Query: 431 DKLLRFRKQRKKMAKLPKPVVVETF------------FGYDEEASLESDGSSVSYQTDRT 478
D++ K+ +K AK + +++ ++E E SS+S +
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1735
Query: 479 DQTPCTPDDDLEEGMAKEETELRFRQLTMEY------QALQRAYALLQEQVGGTLDAERE 532
D+ LE +A+ E EL Q ME +A Q+A L E A++
Sbjct: 1736 DEKR-----RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790
Query: 533 VKTREQLQAEVQRAQARIEDLEKAL------------AEQGQDMKWIE----EKQA---- 572
R+QL+ + + ++++ ++E A+ A+ Q + +E EKQA
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850
Query: 573 LYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAIS 626
L +++++L E + Q+E E + A N ++ +LEE E +S I+
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904
Score = 63.2 bits (152), Expect = 1e-09
Identities = 78/435 (17%), Positives = 188/435 (43%), Gaps = 60/435 (13%)
Query: 20 ALQAANEDLRAKLTDIQIELQQEKSKVSKVE---------------------REKNQEL- 57
AL+ E+++ +L +++ ELQ + ++E EK ++L
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 58 RQVREHE-----QHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNE 112
RQ+ E+E + K L K KL E +K+L+ ++ ++ E + ++ K++
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKL-EGDLKDLELQADSAIKGREEAIKQLRKLQ--- 1658
Query: 113 NQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVE--- 169
+++ L D + + ++ E+ K E + +++Q++++ + A++Q +
Sbjct: 1659 -AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717
Query: 170 EALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECERE---IRRLMEEIKFKDRAVFVLE 226
E L + + ++ + I ++++E E E + + + ++ + L
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777
Query: 227 RELGVQAGHAQRLQLQKEALDEQLSQVR-EADRHPGSPRRELPHAAGAGDA--SDHSGSP 283
EL + AQ+ + ++ L+ Q ++R + G+ + + A +A +
Sbjct: 1778 NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1837
Query: 284 EQQLDEKDARRFQLKIAE--LSAIIRKLEDRNALLSEERNE----------LLKRVREAE 331
EQ+ EK A LK + L I+ ++ED + + + + L +++ EAE
Sbjct: 1838 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE 1897
Query: 332 SQYKPLLDKNKRLSRK-------NEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSS 384
+ + + ++L R+ NE + + +++KL+ + + +R+G R +
Sbjct: 1898 EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIEN 1957
Query: 385 LNDLDQSQDEREVDF 399
+ ++ D R+ DF
Sbjct: 1958 ADGSEEETDTRDADF 1972
Score = 52.4 bits (124), Expect = 2e-06
Identities = 84/386 (21%), Positives = 175/386 (45%), Gaps = 63/386 (16%)
Query: 495 KEETELRFRQLTMEYQAL------QRAYALLQEQVGGTLDAER----------------- 531
+EE +L+ + M +QA+ ++A+A Q+Q+ +R
Sbjct: 786 EEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLF 845
Query: 532 -EVKTREQLQAEVQRAQARIEDLEKALAEQGQ---DMKWIEEKQALYRRNQELVEKIKQM 587
+VK Q+ + + QA+ ++L+K Q + ++K +E+K + + L+++ Q
Sbjct: 846 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 588 ET------EEARLRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQV 641
ET EE R+R + ++ E+L LEE E + + L+
Sbjct: 906 ETELYAEAEEMRVRLAAK-KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964
Query: 642 YCEAEGVT------DIVVAEL-MKKLD----ILGDNANLTNEEQVVVIQARTVLT--LAE 688
E E + V AE +KKL+ ++ D N ++E+ ++ + + LT LAE
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 689 KWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALD----QANKHILELE 744
+ ++ + L+ K + SE E+ K++ +EL+ K+ L+ ++ I +L+
Sbjct: 1025 E--EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQ 1082
Query: 745 AMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQI--LRERMELLQ 802
A + + L+ + K EL + R ++A K + ++RE + I L+E ++ +
Sbjct: 1083 AQIAE-LKMQLAKKEEELQAALARLDDEIA---QKNNALKKIRELEGHISDLQEDLDSER 1138
Query: 803 LAQQRI----KELEERIEAQKRQIKE 824
A+ + ++L E +EA K ++++
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELED 1164
Score = 35.0 bits (79), Expect = 0.29
Identities = 34/144 (23%), Positives = 65/144 (45%), Gaps = 30/144 (20%)
Query: 689 KWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLY 748
K L Q+ E +Q K +L+ KE K + L E L+Q + + E + +L
Sbjct: 849 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKE--------LEQKHSQLTEEKNLLQ 900
Query: 749 DALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRI 808
+ LQ E EL +E E ++++A ++ +E E+L + R+
Sbjct: 901 EQLQAET-----ELYAEAEEMRVRLAAKK-----------------QELEEILHEMEARL 938
Query: 809 KELEERIEAQKRQIKELEEKFLFL 832
+E E+R + + + K++ ++ L L
Sbjct: 939 EEEEDRGQQLQAERKKMAQQMLDL 962
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 103 bits (257), Expect = 7e-22
Identities = 190/884 (21%), Positives = 369/884 (41%), Gaps = 125/884 (14%)
Query: 13 DKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
D E +A LQA +L+ +L + ELQ +++ +KN L+++RE E H +
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH-----I 1127
Query: 73 TELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVK 132
++L+ L E+ +A ++ E E L+ ++ Q L A R+ +
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE-----QE 1182
Query: 133 TVLLSEAKEEAKKGFEVEKVKMQQ-----------EISELKGAKRQVEEALTLVIQADKI 181
+L +A +E + E + +M+Q ++ + K AK +++ + + +
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242
Query: 182 KAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRA-------VFVLERE------ 228
A E+R V ++E+ KK+ E +++ L + +RA V L+ E
Sbjct: 1243 LAGELR-VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301
Query: 229 -LGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQL 287
L G A +L +L QL +E + R++L + + S + QL
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQE--ETRQKLNVSTKLRQLEEERNSLQDQL 1359
Query: 288 DEKDARRFQL----------------KIAELSAIIRKLEDRNALLSEERNELLKRVREAE 331
DE+ + L K+ + ++ + LE+ +E L ++ E
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 332 SQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQS 391
+ Y L RL ++ +DL + ++N+ + V+ N+E +QR N +
Sbjct: 1420 AAYDKLEKTKNRLQQELDDL---VVDLDNQRQLVS--NLEKKQRKFDQLLAEEKNISSKY 1474
Query: 392 QDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLER-DKLLRFRKQRKKMAKLPKPV 450
DER D + + E++ L++ LE A K LER +K+L+ A++ V
Sbjct: 1475 ADER--DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK--------AEMEDLV 1524
Query: 451 VVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQ 510
+ G + LE ++ Q + +D+L+ A E+ +LR L + Q
Sbjct: 1525 SSKDDVGKNVH-ELEKSKRALETQMEEMKTQLEELEDELQ---ATEDAKLR---LEVNMQ 1577
Query: 511 ALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIED--LEKALAEQGQ-----D 563
AL+ + E+ D + E K R QLQ ++ + +ED ++ALA + D
Sbjct: 1578 ALKGQF----ERDLQARDEQNEEK-RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632
Query: 564 MKWIE-EKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKS 622
+K +E + + + +E ++++++++ + + E++DAR + + +E E+K+
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI---FATAKENEKKA 1689
Query: 623 PAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQART 682
++ + + L A D+ EL ++L N +E+
Sbjct: 1690 KSL---EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK-------- 1738
Query: 683 VLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEEL----------DYRKQA 732
E + Q+EE Q M + ++Q L EL + +Q
Sbjct: 1739 --RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1796
Query: 733 LDQANKHIL----ELEAMLYDALQQEAG---AKVAELLSEEERE-KLKVAVEQWKRQVMS 784
L++ NK + E+E + + AK+A+L + E+E + K A + +Q
Sbjct: 1797 LERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856
Query: 785 ELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEK 828
+L+E Q+ ER Q +Q K R++ KRQ++E EE+
Sbjct: 1857 KLKEILLQVEDERKMAEQYKEQAEKG-NARVKQLKRQLEEAEEE 1899
Score = 99.4 bits (246), Expect = 1e-20
Identities = 194/907 (21%), Positives = 376/907 (41%), Gaps = 171/907 (18%)
Query: 35 IQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLTELKTKLHEEKMKELQAVRETL 94
+Q+ Q+E+ + + E +K +E +Q E+E L EL+ K H + +E ++E L
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENE-------LKELEQK-HSQLTEEKNLLQEQL 903
Query: 95 LRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKG--FEVEKV 152
Q E EL E + ++ L+A + E++ + + +EE +G + E+
Sbjct: 904 --QAETELYA-------EAEEMRVRLAAKKQ-ELEEILHEMEARLEEEEDRGQQLQAERK 953
Query: 153 KMQQEISELKGAKRQVEEALTLVIQADKIKA-AEIRSVYHLHQEEITRIKKECEREIRRL 211
KM Q++ +L+ + + EEA +Q +K+ A A+I+ + ++EI + + + +L
Sbjct: 954 KMAQQMLDLE-EQLEEEEAARQKLQLEKVTAEAKIKKL----EDEILVM----DDQNNKL 1004
Query: 212 MEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAA 271
+E K + + L L + A+ L K + +S++ + R+EL
Sbjct: 1005 SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK 1064
Query: 272 G--AGDASDHSGSPEQQLDEKDARRFQLKI------AELSAIIRKLEDRNALLSEERNEL 323
GDASD +Q+ + A+ +LK+ EL A + +L+D A ++N
Sbjct: 1065 RKLEGDASDF----HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA----QKNNA 1116
Query: 324 LKRVREAESQYKPL---LDKNKRLSRKNE----DLSHALRRMENKLK-----FVTQENIE 371
LK++RE E L LD + K E DL L ++ +L+ TQ+ +
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1176
Query: 372 MRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERD 431
++ + +L++ +S + + + + + ++EL++ LE K+ L+++
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQ----KHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 432 K---------------LLRFRKQ-----RKKMAKLPKPVVVETFFGYDEEASL------- 464
K +L KQ +KK+ + + + G A L
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 465 ------------ESDGSSVSYQTD---RTDQTPCTPDDDLEEGMAKEETELRFRQLTMEY 509
E++G ++ D + Q T + EE K + RQL E
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 510 QALQRAYALLQEQVGGTLDAEREVKTR------------------EQLQAEVQRAQARIE 551
+LQ L E++ + ER + T E L+ +R Q IE
Sbjct: 1353 NSLQDQ---LDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 552 DLEKALAEQGQDMKWIEE-KQALYRRNQELV-----------------EKIKQMETEEAR 593
+L + E+ +E+ K L + +LV K Q+ EE
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 594 LRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVV 653
+ + D RD+ E E RE+++ A+S + L+ E E ++
Sbjct: 1470 ISSKYADERDR--------AEAEAREKETKALSLARAL----EEALEAKEELERTNKMLK 1517
Query: 654 AE---LMKKLDILGDNAN-LTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLE 709
AE L+ D +G N + L ++ + Q + T E+ +++ TE A R V+++
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577
Query: 710 SEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEERE 769
+ K F + DE+ + +++ Q + + E E L D +Q A A A+ E + +
Sbjct: 1578 ALKGQFERDLQARDEQNEEKRR---QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK 1634
Query: 770 KLKVAVE---QWKRQVMSELRERDAQILRERMELLQLAQQR------IKELEERIEAQKR 820
L++ + + + + + +LR+ AQ+ + EL R KE E++ ++ +
Sbjct: 1635 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1694
Query: 821 QIKELEE 827
+ +L+E
Sbjct: 1695 DLMQLQE 1701
Score = 79.3 bits (194), Expect = 1e-14
Identities = 157/771 (20%), Positives = 339/771 (43%), Gaps = 113/771 (14%)
Query: 115 RLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALT- 173
+++ LL R + K L + KE +K E E +++Q+ S+L K ++E L
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 174 ---LVIQADKIK---AAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLER 227
L +A++++ AA+ + + + E R+++E +R ++L E K + + LE
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG-QQLQAERKKMAQQMLDLEE 964
Query: 228 ELGVQAGHAQRLQLQKEALDEQLSQ------VREADRHPGSPRRELPHAAGAGDASDHSG 281
+L + Q+LQL+K + ++ + V + + S R+L D + +
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER-ISDLTTNLA 1023
Query: 282 SPEQQLDE--KDARRFQLKIAELSAIIRK-------LEDRNALLSEERNELLKRVREAES 332
E++ K + + I+EL ++K LE L + ++ +++ + ++
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 333 QYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQ 392
Q + + +L++K E+L AL R++++ + Q+N +++ I ++DL +
Sbjct: 1084 Q---IAELKMQLAKKEEELQAALARLDDE---IAQKNNALKK---IRELEGHISDLQEDL 1134
Query: 393 DEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVV 452
D K + ++++L +EL +K+ LE D L Q++ AK + V V
Sbjct: 1135 DSERAARNKAE-KQKRDLGEELEA-------LKTELE-DTLDSTATQQELRAKREQEVTV 1185
Query: 453 ETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQAL 512
+ +L+ + S Q Q ++L E + E+ + L Q L
Sbjct: 1186 -------LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL--EQFKRAKANLDKNKQTL 1236
Query: 513 QRAYALLQEQVGGTLDAEREVK-TREQLQAEVQRAQARIEDLEKALAE------------ 559
++ A L ++ A++EV+ +++L+A+VQ Q++ D E+A AE
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296
Query: 560 ----------QGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLE 609
+G+ +K ++ +L + Q+ E +++ ++ + +++ ++ L+
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356
Query: 610 FRI-LELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNAN 668
++ E+E ++ IS + D K LQ + T + E K+ +N
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS----TVEALEEGKKRFQKEIENLT 1412
Query: 669 LTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKM----VDLESEKELFSKQKGYLDE 724
EE+ ++E+T+ LQ+++ VDL+++++L S
Sbjct: 1413 QQYEEKAAA-------------YDKLEKTKNRLQQELDDLVVDLDNQRQLVS-------- 1451
Query: 725 ELDYRKQALDQ---ANKHILELEAMLYDALQQEAGAKVAELLS----EEEREKLKVAVEQ 777
L+ +++ DQ K+I A D + EA K + LS EE + K +E+
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1511
Query: 778 WKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEK 828
+ + +E+ + + + +L + + + LE ++E K Q++ELE++
Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHELEKSK-RALETQMEEMKTQLEELEDE 1561
Score = 72.4 bits (176), Expect = 2e-12
Identities = 138/654 (21%), Positives = 266/654 (40%), Gaps = 81/654 (12%)
Query: 26 EDLRAKLTDIQIELQQEKSKVSKVEREKN-------QELRQVREHEQHKTAVLLTELKTK 78
E RA+L D +LQ E V+ + E +++ + Q +L E + K
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 79 LH-EEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVKTVLLS 137
L+ K+++L+ R +L Q + E+ + K N + + L L D +
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEM----EAKQNLERHISTLNIQLSDSKKKLQDFASTV 1394
Query: 138 EAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEI 197
EA EE KK F+ E + Q+ E A ++E+ + Q ++ + L +
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL----V 1450
Query: 198 TRIKKECEREIRRLMEEIKFKDRAVFVLER-ELGVQAGHAQRLQLQKEALDEQLSQVREA 256
+ ++K+ + + L EE + +R E + + L L + AL+E L E
Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR-ALEEALEAKEEL 1509
Query: 257 DRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALL 316
+R + E+ + D G +L EK R + ++ E+ + +LED
Sbjct: 1510 ERTNKMLKAEMEDLVSS---KDDVGKNVHEL-EKSKRALETQMEEMKTQLEELEDELQAT 1565
Query: 317 SEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRA 376
+ + L ++ + Q++ L +NE+ L+R ++ + ++ + R A
Sbjct: 1566 EDAKLRLEVNMQALKGQFERDLQAR---DEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622
Query: 377 GIIRRP--SSLNDLDQSQDE----REVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLER 430
++ L DL+ D RE +L+ ++ Q + + + LE A R
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ--MKDFQRELEDAR-----ASR 1675
Query: 431 DKLLRFRKQRKKMAKLPKPVVVETF------------FGYDEEASLESDGSSVSYQTDRT 478
D++ K+ +K AK + +++ ++E E SS+S +
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1735
Query: 479 DQTPCTPDDDLEEGMAKEETELRFRQLTMEY------QALQRAYALLQEQVGGTLDAERE 532
D+ LE +A+ E EL Q ME +A Q+A L E A++
Sbjct: 1736 DEKR-----RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790
Query: 533 VKTREQLQAEVQRAQARIEDLEKAL------------AEQGQDMKWIE----EKQA---- 572
R+QL+ + + ++++ ++E A+ A+ Q + +E EKQA
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850
Query: 573 LYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAIS 626
L +++++L E + Q+E E + A N ++ +LEE E +S I+
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904
Score = 52.4 bits (124), Expect = 2e-06
Identities = 84/386 (21%), Positives = 175/386 (45%), Gaps = 63/386 (16%)
Query: 495 KEETELRFRQLTMEYQAL------QRAYALLQEQVGGTLDAER----------------- 531
+EE +L+ + M +QA+ ++A+A Q+Q+ +R
Sbjct: 786 EEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLF 845
Query: 532 -EVKTREQLQAEVQRAQARIEDLEKALAEQGQ---DMKWIEEKQALYRRNQELVEKIKQM 587
+VK Q+ + + QA+ ++L+K Q + ++K +E+K + + L+++ Q
Sbjct: 846 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 588 ET------EEARLRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQV 641
ET EE R+R + ++ E+L LEE E + + L+
Sbjct: 906 ETELYAEAEEMRVRLAAK-KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964
Query: 642 YCEAEGVT------DIVVAEL-MKKLD----ILGDNANLTNEEQVVVIQARTVLT--LAE 688
E E + V AE +KKL+ ++ D N ++E+ ++ + + LT LAE
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 689 KWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALD----QANKHILELE 744
+ ++ + L+ K + SE E+ K++ +EL+ K+ L+ ++ I +L+
Sbjct: 1025 E--EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQ 1082
Query: 745 AMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQI--LRERMELLQ 802
A + + L+ + K EL + R ++A K + ++RE + I L+E ++ +
Sbjct: 1083 AQIAE-LKMQLAKKEEELQAALARLDDEIA---QKNNALKKIRELEGHISDLQEDLDSER 1138
Query: 803 LAQQRI----KELEERIEAQKRQIKE 824
A+ + ++L E +EA K ++++
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELED 1164
Score = 35.0 bits (79), Expect = 0.29
Identities = 34/144 (23%), Positives = 65/144 (45%), Gaps = 30/144 (20%)
Query: 689 KWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLY 748
K L Q+ E +Q K +L+ KE K + L E L+Q + + E + +L
Sbjct: 849 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKE--------LEQKHSQLTEEKNLLQ 900
Query: 749 DALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRI 808
+ LQ E EL +E E ++++A ++ +E E+L + R+
Sbjct: 901 EQLQAET-----ELYAEAEEMRVRLAAKK-----------------QELEEILHEMEARL 938
Query: 809 KELEERIEAQKRQIKELEEKFLFL 832
+E E+R + + + K++ ++ L L
Sbjct: 939 EEEEDRGQQLQAERKKMAQQMLDL 962
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 103 bits (257), Expect = 7e-22
Identities = 190/884 (21%), Positives = 369/884 (41%), Gaps = 125/884 (14%)
Query: 13 DKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
D E +A LQA +L+ +L + ELQ +++ +KN L+++RE E H +
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH-----I 1120
Query: 73 TELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVK 132
++L+ L E+ +A ++ E E L+ ++ Q L A R+ +
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE-----QE 1175
Query: 133 TVLLSEAKEEAKKGFEVEKVKMQQ-----------EISELKGAKRQVEEALTLVIQADKI 181
+L +A +E + E + +M+Q ++ + K AK +++ + + +
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235
Query: 182 KAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRA-------VFVLERE------ 228
A E+R V ++E+ KK+ E +++ L + +RA V L+ E
Sbjct: 1236 LAGELR-VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294
Query: 229 -LGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQL 287
L G A +L +L QL +E + R++L + + S + QL
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQE--ETRQKLNVSTKLRQLEEERNSLQDQL 1352
Query: 288 DEKDARRFQL----------------KIAELSAIIRKLEDRNALLSEERNELLKRVREAE 331
DE+ + L K+ + ++ + LE+ +E L ++ E
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 332 SQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQS 391
+ Y L RL ++ +DL + ++N+ + V+ N+E +QR N +
Sbjct: 1413 AAYDKLEKTKNRLQQELDDL---VVDLDNQRQLVS--NLEKKQRKFDQLLAEEKNISSKY 1467
Query: 392 QDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLER-DKLLRFRKQRKKMAKLPKPV 450
DER D + + E++ L++ LE A K LER +K+L+ A++ V
Sbjct: 1468 ADER--DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK--------AEMEDLV 1517
Query: 451 VVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQ 510
+ G + LE ++ Q + +D+L+ A E+ +LR L + Q
Sbjct: 1518 SSKDDVGKNVH-ELEKSKRALETQMEEMKTQLEELEDELQ---ATEDAKLR---LEVNMQ 1570
Query: 511 ALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIED--LEKALAEQGQ-----D 563
AL+ + E+ D + E K R QLQ ++ + +ED ++ALA + D
Sbjct: 1571 ALKGQF----ERDLQARDEQNEEK-RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625
Query: 564 MKWIE-EKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKS 622
+K +E + + + +E ++++++++ + + E++DAR + + +E E+K+
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI---FATAKENEKKA 1682
Query: 623 PAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQART 682
++ + + L A D+ EL ++L N +E+
Sbjct: 1683 KSL---EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK-------- 1731
Query: 683 VLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEEL----------DYRKQA 732
E + Q+EE Q M + ++Q L EL + +Q
Sbjct: 1732 --RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1789
Query: 733 LDQANKHIL----ELEAMLYDALQQEAG---AKVAELLSEEERE-KLKVAVEQWKRQVMS 784
L++ NK + E+E + + AK+A+L + E+E + K A + +Q
Sbjct: 1790 LERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849
Query: 785 ELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEK 828
+L+E Q+ ER Q +Q K R++ KRQ++E EE+
Sbjct: 1850 KLKEILLQVEDERKMAEQYKEQAEKG-NARVKQLKRQLEEAEEE 1892
Score = 99.4 bits (246), Expect = 1e-20
Identities = 194/907 (21%), Positives = 376/907 (41%), Gaps = 171/907 (18%)
Query: 35 IQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLTELKTKLHEEKMKELQAVRETL 94
+Q+ Q+E+ + + E +K +E +Q E+E L EL+ K H + +E ++E L
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENE-------LKELEQK-HSQLTEEKNLLQEQL 896
Query: 95 LRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKG--FEVEKV 152
Q E EL E + ++ L+A + E++ + + +EE +G + E+
Sbjct: 897 --QAETELYA-------EAEEMRVRLAAKKQ-ELEEILHEMEARLEEEEDRGQQLQAERK 946
Query: 153 KMQQEISELKGAKRQVEEALTLVIQADKIKA-AEIRSVYHLHQEEITRIKKECEREIRRL 211
KM Q++ +L+ + + EEA +Q +K+ A A+I+ + ++EI + + + +L
Sbjct: 947 KMAQQMLDLE-EQLEEEEAARQKLQLEKVTAEAKIKKL----EDEILVM----DDQNNKL 997
Query: 212 MEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAA 271
+E K + + L L + A+ L K + +S++ + R+EL
Sbjct: 998 SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK 1057
Query: 272 G--AGDASDHSGSPEQQLDEKDARRFQLKI------AELSAIIRKLEDRNALLSEERNEL 323
GDASD +Q+ + A+ +LK+ EL A + +L+D A ++N
Sbjct: 1058 RKLEGDASDF----HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA----QKNNA 1109
Query: 324 LKRVREAESQYKPL---LDKNKRLSRKNE----DLSHALRRMENKLK-----FVTQENIE 371
LK++RE E L LD + K E DL L ++ +L+ TQ+ +
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1169
Query: 372 MRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERD 431
++ + +L++ +S + + + + + ++EL++ LE K+ L+++
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQ----KHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 432 K---------------LLRFRKQ-----RKKMAKLPKPVVVETFFGYDEEASL------- 464
K +L KQ +KK+ + + + G A L
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 465 ------------ESDGSSVSYQTD---RTDQTPCTPDDDLEEGMAKEETELRFRQLTMEY 509
E++G ++ D + Q T + EE K + RQL E
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 510 QALQRAYALLQEQVGGTLDAEREVKTR------------------EQLQAEVQRAQARIE 551
+LQ L E++ + ER + T E L+ +R Q IE
Sbjct: 1346 NSLQDQ---LDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 552 DLEKALAEQGQDMKWIEE-KQALYRRNQELV-----------------EKIKQMETEEAR 593
+L + E+ +E+ K L + +LV K Q+ EE
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 594 LRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVV 653
+ + D RD+ E E RE+++ A+S + L+ E E ++
Sbjct: 1463 ISSKYADERDR--------AEAEAREKETKALSLARAL----EEALEAKEELERTNKMLK 1510
Query: 654 AE---LMKKLDILGDNAN-LTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLE 709
AE L+ D +G N + L ++ + Q + T E+ +++ TE A R V+++
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570
Query: 710 SEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEERE 769
+ K F + DE+ + +++ Q + + E E L D +Q A A A+ E + +
Sbjct: 1571 ALKGQFERDLQARDEQNEEKRR---QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK 1627
Query: 770 KLKVAVE---QWKRQVMSELRERDAQILRERMELLQLAQQR------IKELEERIEAQKR 820
L++ + + + + + +LR+ AQ+ + EL R KE E++ ++ +
Sbjct: 1628 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1687
Query: 821 QIKELEE 827
+ +L+E
Sbjct: 1688 DLMQLQE 1694
Score = 79.3 bits (194), Expect = 1e-14
Identities = 157/771 (20%), Positives = 339/771 (43%), Gaps = 113/771 (14%)
Query: 115 RLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALT- 173
+++ LL R + K L + KE +K E E +++Q+ S+L K ++E L
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 174 ---LVIQADKIK---AAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLER 227
L +A++++ AA+ + + + E R+++E +R ++L E K + + LE
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG-QQLQAERKKMAQQMLDLEE 957
Query: 228 ELGVQAGHAQRLQLQKEALDEQLSQ------VREADRHPGSPRRELPHAAGAGDASDHSG 281
+L + Q+LQL+K + ++ + V + + S R+L D + +
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER-ISDLTTNLA 1016
Query: 282 SPEQQLDE--KDARRFQLKIAELSAIIRK-------LEDRNALLSEERNELLKRVREAES 332
E++ K + + I+EL ++K LE L + ++ +++ + ++
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 333 QYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQ 392
Q + + +L++K E+L AL R++++ + Q+N +++ I ++DL +
Sbjct: 1077 Q---IAELKMQLAKKEEELQAALARLDDE---IAQKNNALKK---IRELEGHISDLQEDL 1127
Query: 393 DEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVV 452
D K + ++++L +EL +K+ LE D L Q++ AK + V V
Sbjct: 1128 DSERAARNKAE-KQKRDLGEELEA-------LKTELE-DTLDSTATQQELRAKREQEVTV 1178
Query: 453 ETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQAL 512
+ +L+ + S Q Q ++L E + E+ + L Q L
Sbjct: 1179 -------LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL--EQFKRAKANLDKNKQTL 1229
Query: 513 QRAYALLQEQVGGTLDAEREVK-TREQLQAEVQRAQARIEDLEKALAE------------ 559
++ A L ++ A++EV+ +++L+A+VQ Q++ D E+A AE
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Query: 560 ----------QGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLE 609
+G+ +K ++ +L + Q+ E +++ ++ + +++ ++ L+
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349
Query: 610 FRI-LELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNAN 668
++ E+E ++ IS + D K LQ + T + E K+ +N
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS----TVEALEEGKKRFQKEIENLT 1405
Query: 669 LTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKM----VDLESEKELFSKQKGYLDE 724
EE+ ++E+T+ LQ+++ VDL+++++L S
Sbjct: 1406 QQYEEKAAA-------------YDKLEKTKNRLQQELDDLVVDLDNQRQLVS-------- 1444
Query: 725 ELDYRKQALDQ---ANKHILELEAMLYDALQQEAGAKVAELLS----EEEREKLKVAVEQ 777
L+ +++ DQ K+I A D + EA K + LS EE + K +E+
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1504
Query: 778 WKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEK 828
+ + +E+ + + + +L + + + LE ++E K Q++ELE++
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSK-RALETQMEEMKTQLEELEDE 1554
Score = 72.4 bits (176), Expect = 2e-12
Identities = 138/654 (21%), Positives = 266/654 (40%), Gaps = 81/654 (12%)
Query: 26 EDLRAKLTDIQIELQQEKSKVSKVEREKN-------QELRQVREHEQHKTAVLLTELKTK 78
E RA+L D +LQ E V+ + E +++ + Q +L E + K
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 79 LH-EEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVKTVLLS 137
L+ K+++L+ R +L Q + E+ + K N + + L L D +
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEM----EAKQNLERHISTLNIQLSDSKKKLQDFASTV 1387
Query: 138 EAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEI 197
EA EE KK F+ E + Q+ E A ++E+ + Q ++ + L +
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL----V 1443
Query: 198 TRIKKECEREIRRLMEEIKFKDRAVFVLER-ELGVQAGHAQRLQLQKEALDEQLSQVREA 256
+ ++K+ + + L EE + +R E + + L L + AL+E L E
Sbjct: 1444 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR-ALEEALEAKEEL 1502
Query: 257 DRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALL 316
+R + E+ + D G +L EK R + ++ E+ + +LED
Sbjct: 1503 ERTNKMLKAEMEDLVSS---KDDVGKNVHEL-EKSKRALETQMEEMKTQLEELEDELQAT 1558
Query: 317 SEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRA 376
+ + L ++ + Q++ L +NE+ L+R ++ + ++ + R A
Sbjct: 1559 EDAKLRLEVNMQALKGQFERDLQAR---DEQNEEKRRQLQRQLHEYETELEDERKQRALA 1615
Query: 377 GIIRRP--SSLNDLDQSQDE----REVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLER 430
++ L DL+ D RE +L+ ++ Q + + + LE A R
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ--MKDFQRELEDAR-----ASR 1668
Query: 431 DKLLRFRKQRKKMAKLPKPVVVETF------------FGYDEEASLESDGSSVSYQTDRT 478
D++ K+ +K AK + +++ ++E E SS+S +
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1728
Query: 479 DQTPCTPDDDLEEGMAKEETELRFRQLTMEY------QALQRAYALLQEQVGGTLDAERE 532
D+ LE +A+ E EL Q ME +A Q+A L E A++
Sbjct: 1729 DEKR-----RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783
Query: 533 VKTREQLQAEVQRAQARIEDLEKAL------------AEQGQDMKWIE----EKQA---- 572
R+QL+ + + ++++ ++E A+ A+ Q + +E EKQA
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 573 LYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAIS 626
L +++++L E + Q+E E + A N ++ +LEE E +S I+
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897
Score = 52.4 bits (124), Expect = 2e-06
Identities = 84/386 (21%), Positives = 175/386 (45%), Gaps = 63/386 (16%)
Query: 495 KEETELRFRQLTMEYQAL------QRAYALLQEQVGGTLDAER----------------- 531
+EE +L+ + M +QA+ ++A+A Q+Q+ +R
Sbjct: 779 EEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLF 838
Query: 532 -EVKTREQLQAEVQRAQARIEDLEKALAEQGQ---DMKWIEEKQALYRRNQELVEKIKQM 587
+VK Q+ + + QA+ ++L+K Q + ++K +E+K + + L+++ Q
Sbjct: 839 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 588 ET------EEARLRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQV 641
ET EE R+R + ++ E+L LEE E + + L+
Sbjct: 899 ETELYAEAEEMRVRLAAK-KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 642 YCEAEGVT------DIVVAEL-MKKLD----ILGDNANLTNEEQVVVIQARTVLT--LAE 688
E E + V AE +KKL+ ++ D N ++E+ ++ + + LT LAE
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 689 KWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALD----QANKHILELE 744
+ ++ + L+ K + SE E+ K++ +EL+ K+ L+ ++ I +L+
Sbjct: 1018 E--EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQ 1075
Query: 745 AMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQI--LRERMELLQ 802
A + + L+ + K EL + R ++A K + ++RE + I L+E ++ +
Sbjct: 1076 AQIAE-LKMQLAKKEEELQAALARLDDEIA---QKNNALKKIRELEGHISDLQEDLDSER 1131
Query: 803 LAQQRI----KELEERIEAQKRQIKE 824
A+ + ++L E +EA K ++++
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELED 1157
Score = 35.0 bits (79), Expect = 0.29
Identities = 34/144 (23%), Positives = 65/144 (45%), Gaps = 30/144 (20%)
Query: 689 KWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLY 748
K L Q+ E +Q K +L+ KE K + L E L+Q + + E + +L
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKE--------LEQKHSQLTEEKNLLQ 893
Query: 749 DALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRI 808
+ LQ E EL +E E ++++A ++ +E E+L + R+
Sbjct: 894 EQLQAET-----ELYAEAEEMRVRLAAKK-----------------QELEEILHEMEARL 931
Query: 809 KELEERIEAQKRQIKELEEKFLFL 832
+E E+R + + + K++ ++ L L
Sbjct: 932 EEEEDRGQQLQAERKKMAQQMLDL 955
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 103 bits (257), Expect = 7e-22
Identities = 181/859 (21%), Positives = 360/859 (41%), Gaps = 102/859 (11%)
Query: 16 EALAALQAANEDLRAKLTDIQIELQ---QEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
EA AA Q E L A+L ++ E++ K++ + R +++ +Q E E + L
Sbjct: 1742 EAAAATQKRQE-LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1800
Query: 73 TELKT--KLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEK 130
E L EE ++ Q E RQ AE RV+ ++L A+ A R +
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQR-AEAERVLA------EKLAAIGEATRLKTEAE 1853
Query: 131 VKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVY 190
+ E ++ E E + ++ + K +EE L + +A + + +
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1913
Query: 191 HLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQL 250
E+ R +++ E EI L + LE ELG +A+ KE + +
Sbjct: 1914 ----EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1969
Query: 251 SQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLE 310
++ R+ RRE A++ + +++ ++ R + K+ E + + E
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2029
Query: 311 DRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENI 370
+A + E ++ +AE + + +K ++L L++ ++ L
Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAF-----AVQQKEQELQQTLQQEQSVLD------- 2077
Query: 371 EMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLER 430
++R A RR + + + Q ERE + Q+ E + L + + ++ E+
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 431 -----DKLLRFRKQRKKMAKLPKPVV---VETFFGYDEE-----ASLESDGSSVSYQTDR 477
++ R Q ++ A K +E + E+ A +E + +++ Q +
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 478 TDQTPCTPDDDL--------EEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDA 529
TD D++L E + + E + ++ + L + A ++ + +
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2257
Query: 530 EREVKTREQLQAEVQRAQARIED---LEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQ 586
+++ T+ LQ E ++ + E+ L A E + + EE A R E + K K
Sbjct: 2258 DKD-NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316
Query: 587 METEEA-RLRHEVQDARDQNELLEFRILEL-EERERKSPAIS-----FHHTPFVDGKSPL 639
+EA RL+ E + + Q EL + + L E++E+ + ++ F T + + L
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 640 QVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEA 699
++ EAE + + VAE+ + A EE A+++ +Q EE
Sbjct: 2377 EMSAEAERL-KLRVAEMSR--------AQARAEED------------AQRFRKQAEEIGE 2415
Query: 700 ALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAML---YDALQQEAG 756
L R EL +++K L + L+ ++Q D + + E A L + LQQE
Sbjct: 2416 KLHR--------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE-- 2465
Query: 757 AKVAELLSEE----EREKLKVAVEQWKRQVMSE---LRERDAQILRERMELLQLAQQRIK 809
AK+ +L SEE ++E+L + ++ +SE L +R+ I +E+ +L QL Q +
Sbjct: 2466 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525
Query: 810 ELEERIEAQKRQIKELEEK 828
+ ++ E Q+RQ +++E++
Sbjct: 2526 KAQQLREEQQRQQQQMEQE 2544
Score = 95.9 bits (237), Expect = 1e-19
Identities = 150/689 (21%), Positives = 284/689 (41%), Gaps = 92/689 (13%)
Query: 9 RAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQ-ELRQVREHEQHK 67
R + E + AL+A+ E A ++++EL + +S R K Q EL R+ +
Sbjct: 1918 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ--- 1974
Query: 68 TAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRV--IKIKDNENQRLQALL----- 120
E + + EE++++ A E RQ +A L V +K K E +RL+
Sbjct: 1975 -LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033
Query: 121 ---------SALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEA 171
+ R EK + + ++E ++ + E+ + Q E + A+R EEA
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093
Query: 172 LTLVIQADKIKAAEIRSVYHLH----------------QEEITRIKKECEREIRRLMEEI 215
+QA++ A R V Q +++KE E+E R +
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153
Query: 216 KFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLS----QVREADRHPGSPRRELPHA- 270
+ R + E+ A++ QK ++++L+ Q+ E D EL
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213
Query: 271 AGAGDASDHSGSPEQQL-----DEKDARRFQLKI-AELSAIIRKLEDRNALLSEERNELL 324
A A +A+ E++L ++ + + +I AE A+I + +D +E E +
Sbjct: 2214 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2273
Query: 325 KRVREAESQYKPLLDKNKRLSR-KNEDLSHALRRMENKLKF---VTQENIEMRQRAGIIR 380
K+V E ++ + RL + EDL+ E LK QE ++ A +++
Sbjct: 2274 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2333
Query: 381 RPSSLNDLDQSQDEREVDFLKLQIVE-----QQNLIDELSKTLETAGYVKSVLER----- 430
+ L + + + + + Q+ E Q+ L E + LE + + + R
Sbjct: 2334 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2393
Query: 431 -------DKLLRFRKQ---------RKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQ 474
+ RFRKQ R ++A K +V+T +++ +++ +
Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453
Query: 475 TDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAY-----ALLQ-----EQVG 524
++ + L + ++E ++ QL E QALQ+++ +LLQ EQ
Sbjct: 2454 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2513
Query: 525 GTLDA--EREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMK--WIEEKQALYRRNQEL 580
L+ + EV +QL+ E QR Q ++E + L ++ + E ++ + R+ +EL
Sbjct: 2514 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2573
Query: 581 VEKIKQMETEEARLRHEVQDARDQNELLE 609
+ +Q +E L E Q R+Q +LLE
Sbjct: 2574 QQLEQQRRQQEELLAEENQRLREQLQLLE 2602
Score = 95.5 bits (236), Expect = 2e-19
Identities = 181/811 (22%), Positives = 336/811 (41%), Gaps = 113/811 (13%)
Query: 39 LQQEKSKVSKVEREKNQELRQVRE--HEQHKTAVLLTELKTKLHEEKMKELQAVRETLLR 96
+++E+ + E+ + L +V +Q + A + K + E + Q ++E ++R
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 97 QHEAELLRVIKIKDNENQR--LQALLSALRDGGPEKVKT-VLLSEAKEEAKKGFEVE--K 151
+ EA + D + Q+ +Q L LR +++ +EA E ++ E E
Sbjct: 1404 REEAAV-------DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1456
Query: 152 VKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRL 211
V++Q E +E + + E +QA + +A E + QEE R++++ + E +R
Sbjct: 1457 VRLQLEATERQRGGAEGE------LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR- 1509
Query: 212 MEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAA 271
K +A L + +A A+ Q +AL+E Q EA+R + E+ A
Sbjct: 1510 ------KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERAR 1561
Query: 272 GAGDASDHS-GSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREA 330
A + + S E +L K A F K A+L R L++ + +++ R E +R ++
Sbjct: 1562 QVQVALETAQRSAEAELQSKRA-SFAEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQ 1617
Query: 331 ESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQ 390
+ + + L R + ALR + + E+ Q+ + + + +
Sbjct: 1618 AEAERAREEAERELERWQLKANEALR--------LRLQAEEVAQQKSLAQAEAEKQKEEA 1669
Query: 391 SQDEREVDFLKLQIVEQQNLID-ELSKTLETA-GYVKSVLERD-KLLRFRKQRKKMAKLP 447
++ R + Q V Q+ L + EL K + A G + L + +L+R R
Sbjct: 1670 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR---------- 1719
Query: 448 KPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTM 507
ET G + LE + + + + Q ++E E ++
Sbjct: 1720 ----AETEQGEQQRQLLEEELARLQREAAAATQ-------------KRQELEAELAKVRA 1762
Query: 508 EYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLE--KALAEQGQDMK 565
E + L + A +E+ T + K++++L+AE R + E+ +ALAE+ + +
Sbjct: 1763 EMEVLLASKARAEEESRSTSE-----KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817
Query: 566 WIEEKQALYRR---NQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEE----- 617
+ E+ A +R + L EK+ + E RL+ E + A + E R+ L E
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 618 RERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKL--DILGDNANLTNEEQV 675
R R + H + + L+ ++E E K L D L + EE++
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSE-------LERQKGLVEDTLRQRRQV--EEEI 1927
Query: 676 VVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQ 735
+ ++A A K E L+ + +E L SK++ L E ++Q +
Sbjct: 1928 LALKASFEKAAAGK-------AELELELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAE 1978
Query: 736 ANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILR 795
+ E E + +L E A + EE E+LK VE+ +R LRER Q
Sbjct: 1979 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR-----LRERAEQESA 2033
Query: 796 ERMELLQLAQQRIKELEERIEAQKRQIKELE 826
+++L Q A Q+ + EE+ A Q KE E
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2064
Score = 92.4 bits (228), Expect = 2e-18
Identities = 173/835 (20%), Positives = 335/835 (40%), Gaps = 121/835 (14%)
Query: 48 KVEREKNQELRQVREHEQ---HKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLR 104
+ E E+ ++ RQ+ E E + A T+ + +L E ++ +++A E LL
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL-EAELAKVRAEMEVLLASKARAEEE 1777
Query: 105 VIKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGA 164
+ QRL+A R+ E + L+E + ++ E + + + E A
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE------A 1831
Query: 165 KRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECERE-IRRLMEEIKFKDRAVF 223
+R + E L + +A ++K + EI +KE E E +RRL E+ F+ R +
Sbjct: 1832 ERVLAEKLAAIGEATRLKT----------EAEIALKEKEAENERLRRLAEDEAFQRRRLE 1881
Query: 224 ---------VLERELGVQAGHAQRLQLQKEALDEQLSQVREADRH------------PGS 262
+ ER ++ L+ QK +++ L Q R+ + G
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1941
Query: 263 PRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEER-N 321
EL +A D S EQ E +A R + AE E+R +EER
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAE--------EERRRREAEERVQ 1991
Query: 322 ELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRR 381
+ L EA Q K L++ +RL K E+ RR+ + + + +++ Q A R
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRL 2047
Query: 382 PSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKL------LR 435
+ + ++E + L+ + ++Q+++D+L E A E ++ +
Sbjct: 2048 QAEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106
Query: 436 FRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAK 495
R+Q ++ +L + + +A+ E + R Q + A+
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2166
Query: 496 EETELRFRQLTMEYQA-LQRAYALLQEQVGGT---------------LDAEREVKTREQL 539
E +F + T+ +A +++ L+ Q+ T +A + R Q+
Sbjct: 2167 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2226
Query: 540 QAEVQRAQARIEDLEKALA--EQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHE 597
+ E+ + ++E+L K A E + +K R QE EK+KQ+ E ARL
Sbjct: 2227 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2286
Query: 598 VQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELM 657
Q+A +L E + + K K +Q EA L
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKML------------KEKMQAVQEA--------TRLK 2326
Query: 658 KKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSK 717
+ ++L L E QAR + E+ QQ+ E QR + + E +++L
Sbjct: 2327 AEAELLQQQKELAQE------QARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQLEMS 2379
Query: 718 QKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKV--AELLSEEEREKLKVAV 775
+ E L R + +A E +A + +E G K+ EL ++E KV +
Sbjct: 2380 AEA---ERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQE-----KVTL 2430
Query: 776 EQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEKFL 830
Q ++ + + DA+ LRE + L+ ++++++ + ++ + +++ ++++ L
Sbjct: 2431 VQ-TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2484
Score = 83.6 bits (205), Expect = 7e-16
Identities = 184/880 (20%), Positives = 364/880 (41%), Gaps = 107/880 (12%)
Query: 10 AKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTA 69
A+ +K AL A LR++L +L+Q +S +S + EK + + V Q
Sbjct: 1045 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS-LSAIYLEKLKTISLVIRGTQGAEE 1103
Query: 70 VLLTELKTKLHEEKMKELQAVRETL--LRQHEAELLRVIKIKDNENQRLQALLSALRDGG 127
VL + HEE++KE QAV TL L +A L ++ + + AL LR G
Sbjct: 1104 VL------RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR--G 1155
Query: 128 PEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIR 187
++V E ++ +VE + ++ +++L +E ++ Q D ++ E+
Sbjct: 1156 AQEV-----GERLQQRHGERDVEVERWRERVAQL------LERWQAVLAQTD-VRQRELE 1203
Query: 188 SV---YHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERE--------LGVQAGHA 236
+ ++E + + + RR E+I+ A RE L H
Sbjct: 1204 QLGRQLRYYRESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1262
Query: 237 QRLQLQKEALDEQLSQVREADRHPGSPRREL-PHAAGAGDASDHSGSPEQQLDEKDARRF 295
++++ + + ++ +++ + + + +L P A+ A SGS + D R
Sbjct: 1263 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1322
Query: 296 QLKIAEL--------SAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRK 347
++ L S +R++E+ L ++R E +R+ E E+ L+K ++L+
Sbjct: 1323 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA----ALEKQRQLAEA 1378
Query: 348 NEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQ 407
+ R +L+ QE + R+ A + + + ++ Q R+ ++Q +
Sbjct: 1379 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1438
Query: 408 QNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESD 467
Q E S+ + E +++R + + + + ++ EEA E+
Sbjct: 1439 QAEAAERSRL--------RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA--EAQ 1488
Query: 468 GSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTL 527
+ +R + D+ + A+ E R + + QRA L+E
Sbjct: 1489 KRQAQEEAERLRRQ--VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1546
Query: 528 DAER-----EVKTREQLQAEVQRAQ----ARIEDLEKALAEQ-GQDMKWIEEKQALYRRN 577
+AER EV+ Q+Q ++ AQ A ++ + AE+ Q + ++E+ +
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1606
Query: 578 QELVEKIKQMETEEARLRHEVQDARDQ-----NELLEFRILELEERERKSPAISFHHTPF 632
+E E+ Q + E R R E + ++ NE L R+ E ++KS A +
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 633 VDGKSPLQVYCEAEGVT----DIVVAELMKKLDILGDNA--NLTNEEQVVVIQART---- 682
+ + + +AE ++ EL K+ + A L E++++ ++A T
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 683 -VLTLAEKWLQQIEETEAALQRKMVDLE-------SEKELFSKQKGYLDEELDYRKQALD 734
L E+ L +++ AA +K +LE +E E+ K +EE ++
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE----SRSTS 1782
Query: 735 QANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQIL 794
+ +K LE EA + L +EA A L+EE + + ++A E RQ R ++L
Sbjct: 1783 EKSKQRLEAEAGRFRELAEEAARLRA--LAEEAKRQRQLAEEDAARQ-----RAEAERVL 1835
Query: 795 RERMELLQLAQQRIKELE---ERIEAQKRQIKELEEKFLF 831
E++ + A + E E + EA+ +++ L E F
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875
Score = 45.8 bits (107), Expect = 2e-04
Identities = 71/344 (20%), Positives = 142/344 (41%), Gaps = 61/344 (17%)
Query: 16 EALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLT-- 73
E L + A ++ + ++I+ QQ ++ RE EL + +E Q + +L
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL-REAIAELEREKEKLQQEAKLLQLKS 2473
Query: 74 -ELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVK 132
E++T E+ ++E QA++++ L + ++ LL+ + + E +L+ L E K
Sbjct: 2474 EEMQTVQQEQLLQETQALQQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ------DEVAK 2526
Query: 133 TVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHL 192
L E ++ ++ E E+ ++ + E + + + EE +
Sbjct: 2527 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------------------RR 2568
Query: 193 HQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQ--- 249
QEE+ +++++ RR EE+ ++ QRL+ Q + L+EQ
Sbjct: 2569 KQEELQQLEQQ-----RRQQEELLAEEN----------------QRLREQLQLLEEQHRA 2607
Query: 250 -LSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLD----EKDARRFQLKIAELSA 304
L+ E + + LP+ A D PE D + A+R Q +
Sbjct: 2608 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2667
Query: 305 IIRKLEDRNALLSE-ERNELLKRVREAESQYKPLLDK--NKRLS 345
+++L + + E R E ++ + S LL K N++LS
Sbjct: 2668 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLS 2711
Score = 41.2 bits (95), Expect = 0.004
Identities = 71/329 (21%), Positives = 130/329 (39%), Gaps = 40/329 (12%)
Query: 507 MEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKW 566
+ +Q+L+R L++ T + + R+ L + QA + D + A +D
Sbjct: 894 LAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 953
Query: 567 IE-EKQALYRRNQELVEKIKQMETEEARLRH---EVQDARDQNELLEFRI-------LEL 615
E E + Q+L++ ++Q EE+R + E++D R Q E E R L+
Sbjct: 954 AEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1013
Query: 616 EERERKSPAISFHHTPFVD----GKSPLQVYCEAEGVTDI-----VVAELMKKLDILGDN 666
E + I+ + GK ++ EAE V + L +L++
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073
Query: 667 ANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEEL 726
+ ++ ++L + Q EE A + ++ + ++ EL
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL--------PEL 1125
Query: 727 DYRKQALDQANKHILELEAMLYDALQQE--AGAKVAELLSEEEREKLKVAVEQWKRQVMS 784
+ K +L + E + +DAL+ E +V E L + E+ V VE+W
Sbjct: 1126 EATKASLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERW------ 1177
Query: 785 ELRERDAQILRERMELLQLAQQRIKELEE 813
RER AQ+L +L R +ELE+
Sbjct: 1178 --RERVAQLLERWQAVLAQTDVRQRELEQ 1204
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 103 bits (257), Expect = 7e-22
Identities = 181/859 (21%), Positives = 360/859 (41%), Gaps = 102/859 (11%)
Query: 16 EALAALQAANEDLRAKLTDIQIELQ---QEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
EA AA Q E L A+L ++ E++ K++ + R +++ +Q E E + L
Sbjct: 1746 EAAAATQKRQE-LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1804
Query: 73 TELKT--KLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEK 130
E L EE ++ Q E RQ AE RV+ ++L A+ A R +
Sbjct: 1805 EEAARLRALAEEAKRQRQLAEEDAARQR-AEAERVLA------EKLAAIGEATRLKTEAE 1857
Query: 131 VKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVY 190
+ E ++ E E + ++ + K +EE L + +A + + +
Sbjct: 1858 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1917
Query: 191 HLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQL 250
E+ R +++ E EI L + LE ELG +A+ KE + +
Sbjct: 1918 ----EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1973
Query: 251 SQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLE 310
++ R+ RRE A++ + +++ ++ R + K+ E + + E
Sbjct: 1974 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2033
Query: 311 DRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENI 370
+A + E ++ +AE + + +K ++L L++ ++ L
Sbjct: 2034 QESARQLQLAQEAAQKRLQAEEKAHAF-----AVQQKEQELQQTLQQEQSVLD------- 2081
Query: 371 EMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLER 430
++R A RR + + + Q ERE + Q+ E + L + + ++ E+
Sbjct: 2082 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2141
Query: 431 -----DKLLRFRKQRKKMAKLPKPVV---VETFFGYDEE-----ASLESDGSSVSYQTDR 477
++ R Q ++ A K +E + E+ A +E + +++ Q +
Sbjct: 2142 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2201
Query: 478 TDQTPCTPDDDL--------EEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDA 529
TD D++L E + + E + ++ + L + A ++ + +
Sbjct: 2202 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2261
Query: 530 EREVKTREQLQAEVQRAQARIED---LEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQ 586
+++ T+ LQ E ++ + E+ L A E + + EE A R E + K K
Sbjct: 2262 DKD-NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2320
Query: 587 METEEA-RLRHEVQDARDQNELLEFRILEL-EERERKSPAIS-----FHHTPFVDGKSPL 639
+EA RL+ E + + Q EL + + L E++E+ + ++ F T + + L
Sbjct: 2321 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2380
Query: 640 QVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEA 699
++ EAE + + VAE+ + A EE A+++ +Q EE
Sbjct: 2381 EMSAEAERL-KLRVAEMSR--------AQARAEED------------AQRFRKQAEEIGE 2419
Query: 700 ALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAML---YDALQQEAG 756
L R EL +++K L + L+ ++Q D + + E A L + LQQE
Sbjct: 2420 KLHR--------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE-- 2469
Query: 757 AKVAELLSEE----EREKLKVAVEQWKRQVMSE---LRERDAQILRERMELLQLAQQRIK 809
AK+ +L SEE ++E+L + ++ +SE L +R+ I +E+ +L QL Q +
Sbjct: 2470 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2529
Query: 810 ELEERIEAQKRQIKELEEK 828
+ ++ E Q+RQ +++E++
Sbjct: 2530 KAQQLREEQQRQQQQMEQE 2548
Score = 95.9 bits (237), Expect = 1e-19
Identities = 150/689 (21%), Positives = 284/689 (41%), Gaps = 92/689 (13%)
Query: 9 RAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQ-ELRQVREHEQHK 67
R + E + AL+A+ E A ++++EL + +S R K Q EL R+ +
Sbjct: 1922 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ--- 1978
Query: 68 TAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRV--IKIKDNENQRLQALL----- 120
E + + EE++++ A E RQ +A L V +K K E +RL+
Sbjct: 1979 -LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2037
Query: 121 ---------SALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEA 171
+ R EK + + ++E ++ + E+ + Q E + A+R EEA
Sbjct: 2038 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2097
Query: 172 LTLVIQADKIKAAEIRSVYHLH----------------QEEITRIKKECEREIRRLMEEI 215
+QA++ A R V Q +++KE E+E R +
Sbjct: 2098 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2157
Query: 216 KFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLS----QVREADRHPGSPRRELPHA- 270
+ R + E+ A++ QK ++++L+ Q+ E D EL
Sbjct: 2158 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2217
Query: 271 AGAGDASDHSGSPEQQL-----DEKDARRFQLKI-AELSAIIRKLEDRNALLSEERNELL 324
A A +A+ E++L ++ + + +I AE A+I + +D +E E +
Sbjct: 2218 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2277
Query: 325 KRVREAESQYKPLLDKNKRLSR-KNEDLSHALRRMENKLKF---VTQENIEMRQRAGIIR 380
K+V E ++ + RL + EDL+ E LK QE ++ A +++
Sbjct: 2278 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2337
Query: 381 RPSSLNDLDQSQDEREVDFLKLQIVE-----QQNLIDELSKTLETAGYVKSVLER----- 430
+ L + + + + + Q+ E Q+ L E + LE + + + R
Sbjct: 2338 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2397
Query: 431 -------DKLLRFRKQ---------RKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQ 474
+ RFRKQ R ++A K +V+T +++ +++ +
Sbjct: 2398 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2457
Query: 475 TDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAY-----ALLQ-----EQVG 524
++ + L + ++E ++ QL E QALQ+++ +LLQ EQ
Sbjct: 2458 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2517
Query: 525 GTLDA--EREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMK--WIEEKQALYRRNQEL 580
L+ + EV +QL+ E QR Q ++E + L ++ + E ++ + R+ +EL
Sbjct: 2518 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2577
Query: 581 VEKIKQMETEEARLRHEVQDARDQNELLE 609
+ +Q +E L E Q R+Q +LLE
Sbjct: 2578 QQLEQQRRQQEELLAEENQRLREQLQLLE 2606
Score = 95.5 bits (236), Expect = 2e-19
Identities = 181/811 (22%), Positives = 336/811 (41%), Gaps = 113/811 (13%)
Query: 39 LQQEKSKVSKVEREKNQELRQVRE--HEQHKTAVLLTELKTKLHEEKMKELQAVRETLLR 96
+++E+ + E+ + L +V +Q + A + K + E + Q ++E ++R
Sbjct: 1348 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1407
Query: 97 QHEAELLRVIKIKDNENQR--LQALLSALRDGGPEKVKT-VLLSEAKEEAKKGFEVE--K 151
+ EA + D + Q+ +Q L LR +++ +EA E ++ E E
Sbjct: 1408 REEAAV-------DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1460
Query: 152 VKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRL 211
V++Q E +E + + E +QA + +A E + QEE R++++ + E +R
Sbjct: 1461 VRLQLEATERQRGGAEGE------LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR- 1513
Query: 212 MEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAA 271
K +A L + +A A+ Q +AL+E Q EA+R + E+ A
Sbjct: 1514 ------KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERAR 1565
Query: 272 GAGDASDHS-GSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREA 330
A + + S E +L K A F K A+L R L++ + +++ R E +R ++
Sbjct: 1566 QVQVALETAQRSAEAELQSKRA-SFAEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQ 1621
Query: 331 ESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQ 390
+ + + L R + ALR + + E+ Q+ + + + +
Sbjct: 1622 AEAERAREEAERELERWQLKANEALR--------LRLQAEEVAQQKSLAQAEAEKQKEEA 1673
Query: 391 SQDEREVDFLKLQIVEQQNLID-ELSKTLETA-GYVKSVLERD-KLLRFRKQRKKMAKLP 447
++ R + Q V Q+ L + EL K + A G + L + +L+R R
Sbjct: 1674 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR---------- 1723
Query: 448 KPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTM 507
ET G + LE + + + + Q ++E E ++
Sbjct: 1724 ----AETEQGEQQRQLLEEELARLQREAAAATQ-------------KRQELEAELAKVRA 1766
Query: 508 EYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLE--KALAEQGQDMK 565
E + L + A +E+ T + K++++L+AE R + E+ +ALAE+ + +
Sbjct: 1767 EMEVLLASKARAEEESRSTSE-----KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1821
Query: 566 WIEEKQALYRR---NQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEE----- 617
+ E+ A +R + L EK+ + E RL+ E + A + E R+ L E
Sbjct: 1822 QLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1880
Query: 618 RERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKL--DILGDNANLTNEEQV 675
R R + H + + L+ ++E E K L D L + EE++
Sbjct: 1881 RRRLEEQAAQHKADIEERLAQLRKASDSE-------LERQKGLVEDTLRQRRQV--EEEI 1931
Query: 676 VVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQ 735
+ ++A A K E L+ + +E L SK++ L E ++Q +
Sbjct: 1932 LALKASFEKAAAGK-------AELELELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAE 1982
Query: 736 ANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILR 795
+ E E + +L E A + EE E+LK VE+ +R LRER Q
Sbjct: 1983 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR-----LRERAEQESA 2037
Query: 796 ERMELLQLAQQRIKELEERIEAQKRQIKELE 826
+++L Q A Q+ + EE+ A Q KE E
Sbjct: 2038 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2068
Score = 92.4 bits (228), Expect = 2e-18
Identities = 173/835 (20%), Positives = 335/835 (40%), Gaps = 121/835 (14%)
Query: 48 KVEREKNQELRQVREHEQ---HKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLR 104
+ E E+ ++ RQ+ E E + A T+ + +L E ++ +++A E LL
Sbjct: 1723 RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL-EAELAKVRAEMEVLLASKARAEEE 1781
Query: 105 VIKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGA 164
+ QRL+A R+ E + L+E + ++ E + + + E A
Sbjct: 1782 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE------A 1835
Query: 165 KRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECERE-IRRLMEEIKFKDRAVF 223
+R + E L + +A ++K + EI +KE E E +RRL E+ F+ R +
Sbjct: 1836 ERVLAEKLAAIGEATRLKT----------EAEIALKEKEAENERLRRLAEDEAFQRRRLE 1885
Query: 224 ---------VLERELGVQAGHAQRLQLQKEALDEQLSQVREADRH------------PGS 262
+ ER ++ L+ QK +++ L Q R+ + G
Sbjct: 1886 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1945
Query: 263 PRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEER-N 321
EL +A D S EQ E +A R + AE E+R +EER
Sbjct: 1946 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAE--------EERRRREAEERVQ 1995
Query: 322 ELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRR 381
+ L EA Q K L++ +RL K E+ RR+ + + + +++ Q A R
Sbjct: 1996 KSLAAEEEAARQRKAALEEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRL 2051
Query: 382 PSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKL------LR 435
+ + ++E + L+ + ++Q+++D+L E A E ++ +
Sbjct: 2052 QAEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2110
Query: 436 FRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAK 495
R+Q ++ +L + + +A+ E + R Q + A+
Sbjct: 2111 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2170
Query: 496 EETELRFRQLTMEYQA-LQRAYALLQEQVGGT---------------LDAEREVKTREQL 539
E +F + T+ +A +++ L+ Q+ T +A + R Q+
Sbjct: 2171 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2230
Query: 540 QAEVQRAQARIEDLEKALA--EQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHE 597
+ E+ + ++E+L K A E + +K R QE EK+KQ+ E ARL
Sbjct: 2231 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2290
Query: 598 VQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELM 657
Q+A +L E + + K K +Q EA L
Sbjct: 2291 AQEAARLRQLAEEDLAQQRALAEKML------------KEKMQAVQEA--------TRLK 2330
Query: 658 KKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSK 717
+ ++L L E QAR + E+ QQ+ E QR + + E +++L
Sbjct: 2331 AEAELLQQQKELAQE------QARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQLEMS 2383
Query: 718 QKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKV--AELLSEEEREKLKVAV 775
+ E L R + +A E +A + +E G K+ EL ++E KV +
Sbjct: 2384 AEA---ERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQE-----KVTL 2434
Query: 776 EQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEKFL 830
Q ++ + + DA+ LRE + L+ ++++++ + ++ + +++ ++++ L
Sbjct: 2435 VQ-TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2488
Score = 83.6 bits (205), Expect = 7e-16
Identities = 184/880 (20%), Positives = 364/880 (41%), Gaps = 107/880 (12%)
Query: 10 AKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTA 69
A+ +K AL A LR++L +L+Q +S +S + EK + + V Q
Sbjct: 1049 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS-LSAIYLEKLKTISLVIRGTQGAEE 1107
Query: 70 VLLTELKTKLHEEKMKELQAVRETL--LRQHEAELLRVIKIKDNENQRLQALLSALRDGG 127
VL + HEE++KE QAV TL L +A L ++ + + AL LR G
Sbjct: 1108 VL------RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR--G 1159
Query: 128 PEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIR 187
++V E ++ +VE + ++ +++L +E ++ Q D ++ E+
Sbjct: 1160 AQEV-----GERLQQRHGERDVEVERWRERVAQL------LERWQAVLAQTD-VRQRELE 1207
Query: 188 SV---YHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERE--------LGVQAGHA 236
+ ++E + + + RR E+I+ A RE L H
Sbjct: 1208 QLGRQLRYYRESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1266
Query: 237 QRLQLQKEALDEQLSQVREADRHPGSPRREL-PHAAGAGDASDHSGSPEQQLDEKDARRF 295
++++ + + ++ +++ + + + +L P A+ A SGS + D R
Sbjct: 1267 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1326
Query: 296 QLKIAEL--------SAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRK 347
++ L S +R++E+ L ++R E +R+ E E+ L+K ++L+
Sbjct: 1327 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA----ALEKQRQLAEA 1382
Query: 348 NEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQ 407
+ R +L+ QE + R+ A + + + ++ Q R+ ++Q +
Sbjct: 1383 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1442
Query: 408 QNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESD 467
Q E S+ + E +++R + + + + ++ EEA E+
Sbjct: 1443 QAEAAERSRL--------RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA--EAQ 1492
Query: 468 GSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTL 527
+ +R + D+ + A+ E R + + QRA L+E
Sbjct: 1493 KRQAQEEAERLRRQ--VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1550
Query: 528 DAER-----EVKTREQLQAEVQRAQ----ARIEDLEKALAEQ-GQDMKWIEEKQALYRRN 577
+AER EV+ Q+Q ++ AQ A ++ + AE+ Q + ++E+ +
Sbjct: 1551 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1610
Query: 578 QELVEKIKQMETEEARLRHEVQDARDQ-----NELLEFRILELEERERKSPAISFHHTPF 632
+E E+ Q + E R R E + ++ NE L R+ E ++KS A +
Sbjct: 1611 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1670
Query: 633 VDGKSPLQVYCEAEGVT----DIVVAELMKKLDILGDNA--NLTNEEQVVVIQART---- 682
+ + + +AE ++ EL K+ + A L E++++ ++A T
Sbjct: 1671 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1730
Query: 683 -VLTLAEKWLQQIEETEAALQRKMVDLE-------SEKELFSKQKGYLDEELDYRKQALD 734
L E+ L +++ AA +K +LE +E E+ K +EE ++
Sbjct: 1731 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE----SRSTS 1786
Query: 735 QANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQIL 794
+ +K LE EA + L +EA A L+EE + + ++A E RQ R ++L
Sbjct: 1787 EKSKQRLEAEAGRFRELAEEAARLRA--LAEEAKRQRQLAEEDAARQ-----RAEAERVL 1839
Query: 795 RERMELLQLAQQRIKELE---ERIEAQKRQIKELEEKFLF 831
E++ + A + E E + EA+ +++ L E F
Sbjct: 1840 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1879
Score = 45.8 bits (107), Expect = 2e-04
Identities = 71/344 (20%), Positives = 142/344 (41%), Gaps = 61/344 (17%)
Query: 16 EALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLT-- 73
E L + A ++ + ++I+ QQ ++ RE EL + +E Q + +L
Sbjct: 2419 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL-REAIAELEREKEKLQQEAKLLQLKS 2477
Query: 74 -ELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVK 132
E++T E+ ++E QA++++ L + ++ LL+ + + E +L+ L E K
Sbjct: 2478 EEMQTVQQEQLLQETQALQQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ------DEVAK 2530
Query: 133 TVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHL 192
L E ++ ++ E E+ ++ + E + + + EE +
Sbjct: 2531 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------------------RR 2572
Query: 193 HQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQ--- 249
QEE+ +++++ RR EE+ ++ QRL+ Q + L+EQ
Sbjct: 2573 KQEELQQLEQQ-----RRQQEELLAEEN----------------QRLREQLQLLEEQHRA 2611
Query: 250 -LSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLD----EKDARRFQLKIAELSA 304
L+ E + + LP+ A D PE D + A+R Q +
Sbjct: 2612 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2671
Query: 305 IIRKLEDRNALLSE-ERNELLKRVREAESQYKPLLDK--NKRLS 345
+++L + + E R E ++ + S LL K N++LS
Sbjct: 2672 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLS 2715
Score = 41.2 bits (95), Expect = 0.004
Identities = 71/329 (21%), Positives = 130/329 (39%), Gaps = 40/329 (12%)
Query: 507 MEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKW 566
+ +Q+L+R L++ T + + R+ L + QA + D + A +D
Sbjct: 898 LAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 957
Query: 567 IE-EKQALYRRNQELVEKIKQMETEEARLRH---EVQDARDQNELLEFRI-------LEL 615
E E + Q+L++ ++Q EE+R + E++D R Q E E R L+
Sbjct: 958 AEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1017
Query: 616 EERERKSPAISFHHTPFVD----GKSPLQVYCEAEGVTDI-----VVAELMKKLDILGDN 666
E + I+ + GK ++ EAE V + L +L++
Sbjct: 1018 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1077
Query: 667 ANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEEL 726
+ ++ ++L + Q EE A + ++ + ++ EL
Sbjct: 1078 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL--------PEL 1129
Query: 727 DYRKQALDQANKHILELEAMLYDALQQE--AGAKVAELLSEEEREKLKVAVEQWKRQVMS 784
+ K +L + E + +DAL+ E +V E L + E+ V VE+W
Sbjct: 1130 EATKASLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERW------ 1181
Query: 785 ELRERDAQILRERMELLQLAQQRIKELEE 813
RER AQ+L +L R +ELE+
Sbjct: 1182 --RERVAQLLERWQAVLAQTDVRQRELEQ 1208
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 103 bits (257), Expect = 7e-22
Identities = 181/859 (21%), Positives = 360/859 (41%), Gaps = 102/859 (11%)
Query: 16 EALAALQAANEDLRAKLTDIQIELQ---QEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
EA AA Q E L A+L ++ E++ K++ + R +++ +Q E E + L
Sbjct: 1742 EAAAATQKRQE-LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1800
Query: 73 TELKT--KLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEK 130
E L EE ++ Q E RQ AE RV+ ++L A+ A R +
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQR-AEAERVLA------EKLAAIGEATRLKTEAE 1853
Query: 131 VKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVY 190
+ E ++ E E + ++ + K +EE L + +A + + +
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1913
Query: 191 HLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQL 250
E+ R +++ E EI L + LE ELG +A+ KE + +
Sbjct: 1914 ----EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1969
Query: 251 SQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLE 310
++ R+ RRE A++ + +++ ++ R + K+ E + + E
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2029
Query: 311 DRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENI 370
+A + E ++ +AE + + +K ++L L++ ++ L
Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAF-----AVQQKEQELQQTLQQEQSVLD------- 2077
Query: 371 EMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLER 430
++R A RR + + + Q ERE + Q+ E + L + + ++ E+
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 431 -----DKLLRFRKQRKKMAKLPKPVV---VETFFGYDEE-----ASLESDGSSVSYQTDR 477
++ R Q ++ A K +E + E+ A +E + +++ Q +
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 478 TDQTPCTPDDDL--------EEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDA 529
TD D++L E + + E + ++ + L + A ++ + +
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2257
Query: 530 EREVKTREQLQAEVQRAQARIED---LEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQ 586
+++ T+ LQ E ++ + E+ L A E + + EE A R E + K K
Sbjct: 2258 DKD-NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316
Query: 587 METEEA-RLRHEVQDARDQNELLEFRILEL-EERERKSPAIS-----FHHTPFVDGKSPL 639
+EA RL+ E + + Q EL + + L E++E+ + ++ F T + + L
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 640 QVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEA 699
++ EAE + + VAE+ + A EE A+++ +Q EE
Sbjct: 2377 EMSAEAERL-KLRVAEMSR--------AQARAEED------------AQRFRKQAEEIGE 2415
Query: 700 ALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAML---YDALQQEAG 756
L R EL +++K L + L+ ++Q D + + E A L + LQQE
Sbjct: 2416 KLHR--------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE-- 2465
Query: 757 AKVAELLSEE----EREKLKVAVEQWKRQVMSE---LRERDAQILRERMELLQLAQQRIK 809
AK+ +L SEE ++E+L + ++ +SE L +R+ I +E+ +L QL Q +
Sbjct: 2466 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525
Query: 810 ELEERIEAQKRQIKELEEK 828
+ ++ E Q+RQ +++E++
Sbjct: 2526 KAQQLREEQQRQQQQMEQE 2544
Score = 95.9 bits (237), Expect = 1e-19
Identities = 150/689 (21%), Positives = 284/689 (41%), Gaps = 92/689 (13%)
Query: 9 RAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQ-ELRQVREHEQHK 67
R + E + AL+A+ E A ++++EL + +S R K Q EL R+ +
Sbjct: 1918 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ--- 1974
Query: 68 TAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRV--IKIKDNENQRLQALL----- 120
E + + EE++++ A E RQ +A L V +K K E +RL+
Sbjct: 1975 -LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033
Query: 121 ---------SALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEA 171
+ R EK + + ++E ++ + E+ + Q E + A+R EEA
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093
Query: 172 LTLVIQADKIKAAEIRSVYHLH----------------QEEITRIKKECEREIRRLMEEI 215
+QA++ A R V Q +++KE E+E R +
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153
Query: 216 KFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLS----QVREADRHPGSPRRELPHA- 270
+ R + E+ A++ QK ++++L+ Q+ E D EL
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213
Query: 271 AGAGDASDHSGSPEQQL-----DEKDARRFQLKI-AELSAIIRKLEDRNALLSEERNELL 324
A A +A+ E++L ++ + + +I AE A+I + +D +E E +
Sbjct: 2214 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2273
Query: 325 KRVREAESQYKPLLDKNKRLSR-KNEDLSHALRRMENKLKF---VTQENIEMRQRAGIIR 380
K+V E ++ + RL + EDL+ E LK QE ++ A +++
Sbjct: 2274 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2333
Query: 381 RPSSLNDLDQSQDEREVDFLKLQIVE-----QQNLIDELSKTLETAGYVKSVLER----- 430
+ L + + + + + Q+ E Q+ L E + LE + + + R
Sbjct: 2334 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2393
Query: 431 -------DKLLRFRKQ---------RKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQ 474
+ RFRKQ R ++A K +V+T +++ +++ +
Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453
Query: 475 TDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAY-----ALLQ-----EQVG 524
++ + L + ++E ++ QL E QALQ+++ +LLQ EQ
Sbjct: 2454 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2513
Query: 525 GTLDA--EREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMK--WIEEKQALYRRNQEL 580
L+ + EV +QL+ E QR Q ++E + L ++ + E ++ + R+ +EL
Sbjct: 2514 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2573
Query: 581 VEKIKQMETEEARLRHEVQDARDQNELLE 609
+ +Q +E L E Q R+Q +LLE
Sbjct: 2574 QQLEQQRRQQEELLAEENQRLREQLQLLE 2602
Score = 95.5 bits (236), Expect = 2e-19
Identities = 181/811 (22%), Positives = 336/811 (41%), Gaps = 113/811 (13%)
Query: 39 LQQEKSKVSKVEREKNQELRQVRE--HEQHKTAVLLTELKTKLHEEKMKELQAVRETLLR 96
+++E+ + E+ + L +V +Q + A + K + E + Q ++E ++R
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 97 QHEAELLRVIKIKDNENQR--LQALLSALRDGGPEKVKT-VLLSEAKEEAKKGFEVE--K 151
+ EA + D + Q+ +Q L LR +++ +EA E ++ E E
Sbjct: 1404 REEAAV-------DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1456
Query: 152 VKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRL 211
V++Q E +E + + E +QA + +A E + QEE R++++ + E +R
Sbjct: 1457 VRLQLEATERQRGGAEGE------LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR- 1509
Query: 212 MEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAA 271
K +A L + +A A+ Q +AL+E Q EA+R + E+ A
Sbjct: 1510 ------KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERAR 1561
Query: 272 GAGDASDHS-GSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREA 330
A + + S E +L K A F K A+L R L++ + +++ R E +R ++
Sbjct: 1562 QVQVALETAQRSAEAELQSKRA-SFAEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQ 1617
Query: 331 ESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQ 390
+ + + L R + ALR + + E+ Q+ + + + +
Sbjct: 1618 AEAERAREEAERELERWQLKANEALR--------LRLQAEEVAQQKSLAQAEAEKQKEEA 1669
Query: 391 SQDEREVDFLKLQIVEQQNLID-ELSKTLETA-GYVKSVLERD-KLLRFRKQRKKMAKLP 447
++ R + Q V Q+ L + EL K + A G + L + +L+R R
Sbjct: 1670 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR---------- 1719
Query: 448 KPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTM 507
ET G + LE + + + + Q ++E E ++
Sbjct: 1720 ----AETEQGEQQRQLLEEELARLQREAAAATQ-------------KRQELEAELAKVRA 1762
Query: 508 EYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLE--KALAEQGQDMK 565
E + L + A +E+ T + K++++L+AE R + E+ +ALAE+ + +
Sbjct: 1763 EMEVLLASKARAEEESRSTSE-----KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817
Query: 566 WIEEKQALYRR---NQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEE----- 617
+ E+ A +R + L EK+ + E RL+ E + A + E R+ L E
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 618 RERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKL--DILGDNANLTNEEQV 675
R R + H + + L+ ++E E K L D L + EE++
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSE-------LERQKGLVEDTLRQRRQV--EEEI 1927
Query: 676 VVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQ 735
+ ++A A K E L+ + +E L SK++ L E ++Q +
Sbjct: 1928 LALKASFEKAAAGK-------AELELELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAE 1978
Query: 736 ANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILR 795
+ E E + +L E A + EE E+LK VE+ +R LRER Q
Sbjct: 1979 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR-----LRERAEQESA 2033
Query: 796 ERMELLQLAQQRIKELEERIEAQKRQIKELE 826
+++L Q A Q+ + EE+ A Q KE E
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2064
Score = 92.4 bits (228), Expect = 2e-18
Identities = 173/835 (20%), Positives = 335/835 (40%), Gaps = 121/835 (14%)
Query: 48 KVEREKNQELRQVREHEQ---HKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLR 104
+ E E+ ++ RQ+ E E + A T+ + +L E ++ +++A E LL
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL-EAELAKVRAEMEVLLASKARAEEE 1777
Query: 105 VIKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGA 164
+ QRL+A R+ E + L+E + ++ E + + + E A
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE------A 1831
Query: 165 KRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECERE-IRRLMEEIKFKDRAVF 223
+R + E L + +A ++K + EI +KE E E +RRL E+ F+ R +
Sbjct: 1832 ERVLAEKLAAIGEATRLKT----------EAEIALKEKEAENERLRRLAEDEAFQRRRLE 1881
Query: 224 ---------VLERELGVQAGHAQRLQLQKEALDEQLSQVREADRH------------PGS 262
+ ER ++ L+ QK +++ L Q R+ + G
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1941
Query: 263 PRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEER-N 321
EL +A D S EQ E +A R + AE E+R +EER
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAE--------EERRRREAEERVQ 1991
Query: 322 ELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRR 381
+ L EA Q K L++ +RL K E+ RR+ + + + +++ Q A R
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRL 2047
Query: 382 PSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKL------LR 435
+ + ++E + L+ + ++Q+++D+L E A E ++ +
Sbjct: 2048 QAEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106
Query: 436 FRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAK 495
R+Q ++ +L + + +A+ E + R Q + A+
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2166
Query: 496 EETELRFRQLTMEYQA-LQRAYALLQEQVGGT---------------LDAEREVKTREQL 539
E +F + T+ +A +++ L+ Q+ T +A + R Q+
Sbjct: 2167 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2226
Query: 540 QAEVQRAQARIEDLEKALA--EQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHE 597
+ E+ + ++E+L K A E + +K R QE EK+KQ+ E ARL
Sbjct: 2227 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2286
Query: 598 VQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELM 657
Q+A +L E + + K K +Q EA L
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKML------------KEKMQAVQEA--------TRLK 2326
Query: 658 KKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSK 717
+ ++L L E QAR + E+ QQ+ E QR + + E +++L
Sbjct: 2327 AEAELLQQQKELAQE------QARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQLEMS 2379
Query: 718 QKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKV--AELLSEEEREKLKVAV 775
+ E L R + +A E +A + +E G K+ EL ++E KV +
Sbjct: 2380 AEA---ERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQE-----KVTL 2430
Query: 776 EQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEKFL 830
Q ++ + + DA+ LRE + L+ ++++++ + ++ + +++ ++++ L
Sbjct: 2431 VQ-TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2484
Score = 83.6 bits (205), Expect = 7e-16
Identities = 184/880 (20%), Positives = 364/880 (41%), Gaps = 107/880 (12%)
Query: 10 AKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTA 69
A+ +K AL A LR++L +L+Q +S +S + EK + + V Q
Sbjct: 1045 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS-LSAIYLEKLKTISLVIRGTQGAEE 1103
Query: 70 VLLTELKTKLHEEKMKELQAVRETL--LRQHEAELLRVIKIKDNENQRLQALLSALRDGG 127
VL + HEE++KE QAV TL L +A L ++ + + AL LR G
Sbjct: 1104 VL------RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR--G 1155
Query: 128 PEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIR 187
++V E ++ +VE + ++ +++L +E ++ Q D ++ E+
Sbjct: 1156 AQEV-----GERLQQRHGERDVEVERWRERVAQL------LERWQAVLAQTD-VRQRELE 1203
Query: 188 SV---YHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERE--------LGVQAGHA 236
+ ++E + + + RR E+I+ A RE L H
Sbjct: 1204 QLGRQLRYYRESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1262
Query: 237 QRLQLQKEALDEQLSQVREADRHPGSPRREL-PHAAGAGDASDHSGSPEQQLDEKDARRF 295
++++ + + ++ +++ + + + +L P A+ A SGS + D R
Sbjct: 1263 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1322
Query: 296 QLKIAEL--------SAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRK 347
++ L S +R++E+ L ++R E +R+ E E+ L+K ++L+
Sbjct: 1323 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA----ALEKQRQLAEA 1378
Query: 348 NEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQ 407
+ R +L+ QE + R+ A + + + ++ Q R+ ++Q +
Sbjct: 1379 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1438
Query: 408 QNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESD 467
Q E S+ + E +++R + + + + ++ EEA E+
Sbjct: 1439 QAEAAERSRL--------RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA--EAQ 1488
Query: 468 GSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTL 527
+ +R + D+ + A+ E R + + QRA L+E
Sbjct: 1489 KRQAQEEAERLRRQ--VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1546
Query: 528 DAER-----EVKTREQLQAEVQRAQ----ARIEDLEKALAEQ-GQDMKWIEEKQALYRRN 577
+AER EV+ Q+Q ++ AQ A ++ + AE+ Q + ++E+ +
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1606
Query: 578 QELVEKIKQMETEEARLRHEVQDARDQ-----NELLEFRILELEERERKSPAISFHHTPF 632
+E E+ Q + E R R E + ++ NE L R+ E ++KS A +
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 633 VDGKSPLQVYCEAEGVT----DIVVAELMKKLDILGDNA--NLTNEEQVVVIQART---- 682
+ + + +AE ++ EL K+ + A L E++++ ++A T
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 683 -VLTLAEKWLQQIEETEAALQRKMVDLE-------SEKELFSKQKGYLDEELDYRKQALD 734
L E+ L +++ AA +K +LE +E E+ K +EE ++
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE----SRSTS 1782
Query: 735 QANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQIL 794
+ +K LE EA + L +EA A L+EE + + ++A E RQ R ++L
Sbjct: 1783 EKSKQRLEAEAGRFRELAEEAARLRA--LAEEAKRQRQLAEEDAARQ-----RAEAERVL 1835
Query: 795 RERMELLQLAQQRIKELE---ERIEAQKRQIKELEEKFLF 831
E++ + A + E E + EA+ +++ L E F
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875
Score = 45.8 bits (107), Expect = 2e-04
Identities = 71/344 (20%), Positives = 142/344 (41%), Gaps = 61/344 (17%)
Query: 16 EALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLT-- 73
E L + A ++ + ++I+ QQ ++ RE EL + +E Q + +L
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL-REAIAELEREKEKLQQEAKLLQLKS 2473
Query: 74 -ELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVK 132
E++T E+ ++E QA++++ L + ++ LL+ + + E +L+ L E K
Sbjct: 2474 EEMQTVQQEQLLQETQALQQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ------DEVAK 2526
Query: 133 TVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHL 192
L E ++ ++ E E+ ++ + E + + + EE +
Sbjct: 2527 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------------------RR 2568
Query: 193 HQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQ--- 249
QEE+ +++++ RR EE+ ++ QRL+ Q + L+EQ
Sbjct: 2569 KQEELQQLEQQ-----RRQQEELLAEEN----------------QRLREQLQLLEEQHRA 2607
Query: 250 -LSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLD----EKDARRFQLKIAELSA 304
L+ E + + LP+ A D PE D + A+R Q +
Sbjct: 2608 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2667
Query: 305 IIRKLEDRNALLSE-ERNELLKRVREAESQYKPLLDK--NKRLS 345
+++L + + E R E ++ + S LL K N++LS
Sbjct: 2668 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLS 2711
Score = 41.2 bits (95), Expect = 0.004
Identities = 71/329 (21%), Positives = 130/329 (39%), Gaps = 40/329 (12%)
Query: 507 MEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKW 566
+ +Q+L+R L++ T + + R+ L + QA + D + A +D
Sbjct: 894 LAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 953
Query: 567 IE-EKQALYRRNQELVEKIKQMETEEARLRH---EVQDARDQNELLEFRI-------LEL 615
E E + Q+L++ ++Q EE+R + E++D R Q E E R L+
Sbjct: 954 AEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1013
Query: 616 EERERKSPAISFHHTPFVD----GKSPLQVYCEAEGVTDI-----VVAELMKKLDILGDN 666
E + I+ + GK ++ EAE V + L +L++
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073
Query: 667 ANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEEL 726
+ ++ ++L + Q EE A + ++ + ++ EL
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL--------PEL 1125
Query: 727 DYRKQALDQANKHILELEAMLYDALQQE--AGAKVAELLSEEEREKLKVAVEQWKRQVMS 784
+ K +L + E + +DAL+ E +V E L + E+ V VE+W
Sbjct: 1126 EATKASLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERW------ 1177
Query: 785 ELRERDAQILRERMELLQLAQQRIKELEE 813
RER AQ+L +L R +ELE+
Sbjct: 1178 --RERVAQLLERWQAVLAQTDVRQRELEQ 1204
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 103 bits (257), Expect = 7e-22
Identities = 181/859 (21%), Positives = 360/859 (41%), Gaps = 102/859 (11%)
Query: 16 EALAALQAANEDLRAKLTDIQIELQ---QEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
EA AA Q E L A+L ++ E++ K++ + R +++ +Q E E + L
Sbjct: 1710 EAAAATQKRQE-LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1768
Query: 73 TELKT--KLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEK 130
E L EE ++ Q E RQ AE RV+ ++L A+ A R +
Sbjct: 1769 EEAARLRALAEEAKRQRQLAEEDAARQR-AEAERVLA------EKLAAIGEATRLKTEAE 1821
Query: 131 VKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVY 190
+ E ++ E E + ++ + K +EE L + +A + + +
Sbjct: 1822 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1881
Query: 191 HLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQL 250
E+ R +++ E EI L + LE ELG +A+ KE + +
Sbjct: 1882 ----EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1937
Query: 251 SQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLE 310
++ R+ RRE A++ + +++ ++ R + K+ E + + E
Sbjct: 1938 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 1997
Query: 311 DRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENI 370
+A + E ++ +AE + + +K ++L L++ ++ L
Sbjct: 1998 QESARQLQLAQEAAQKRLQAEEKAHAF-----AVQQKEQELQQTLQQEQSVLD------- 2045
Query: 371 EMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLER 430
++R A RR + + + Q ERE + Q+ E + L + + ++ E+
Sbjct: 2046 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2105
Query: 431 -----DKLLRFRKQRKKMAKLPKPVV---VETFFGYDEE-----ASLESDGSSVSYQTDR 477
++ R Q ++ A K +E + E+ A +E + +++ Q +
Sbjct: 2106 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2165
Query: 478 TDQTPCTPDDDL--------EEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDA 529
TD D++L E + + E + ++ + L + A ++ + +
Sbjct: 2166 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2225
Query: 530 EREVKTREQLQAEVQRAQARIED---LEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQ 586
+++ T+ LQ E ++ + E+ L A E + + EE A R E + K K
Sbjct: 2226 DKD-NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2284
Query: 587 METEEA-RLRHEVQDARDQNELLEFRILEL-EERERKSPAIS-----FHHTPFVDGKSPL 639
+EA RL+ E + + Q EL + + L E++E+ + ++ F T + + L
Sbjct: 2285 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2344
Query: 640 QVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEA 699
++ EAE + + VAE+ + A EE A+++ +Q EE
Sbjct: 2345 EMSAEAERL-KLRVAEMSR--------AQARAEED------------AQRFRKQAEEIGE 2383
Query: 700 ALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAML---YDALQQEAG 756
L R EL +++K L + L+ ++Q D + + E A L + LQQE
Sbjct: 2384 KLHR--------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE-- 2433
Query: 757 AKVAELLSEE----EREKLKVAVEQWKRQVMSE---LRERDAQILRERMELLQLAQQRIK 809
AK+ +L SEE ++E+L + ++ +SE L +R+ I +E+ +L QL Q +
Sbjct: 2434 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2493
Query: 810 ELEERIEAQKRQIKELEEK 828
+ ++ E Q+RQ +++E++
Sbjct: 2494 KAQQLREEQQRQQQQMEQE 2512
Score = 95.9 bits (237), Expect = 1e-19
Identities = 150/689 (21%), Positives = 284/689 (41%), Gaps = 92/689 (13%)
Query: 9 RAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQ-ELRQVREHEQHK 67
R + E + AL+A+ E A ++++EL + +S R K Q EL R+ +
Sbjct: 1886 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ--- 1942
Query: 68 TAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRV--IKIKDNENQRLQALL----- 120
E + + EE++++ A E RQ +A L V +K K E +RL+
Sbjct: 1943 -LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2001
Query: 121 ---------SALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEA 171
+ R EK + + ++E ++ + E+ + Q E + A+R EEA
Sbjct: 2002 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2061
Query: 172 LTLVIQADKIKAAEIRSVYHLH----------------QEEITRIKKECEREIRRLMEEI 215
+QA++ A R V Q +++KE E+E R +
Sbjct: 2062 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2121
Query: 216 KFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLS----QVREADRHPGSPRRELPHA- 270
+ R + E+ A++ QK ++++L+ Q+ E D EL
Sbjct: 2122 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2181
Query: 271 AGAGDASDHSGSPEQQL-----DEKDARRFQLKI-AELSAIIRKLEDRNALLSEERNELL 324
A A +A+ E++L ++ + + +I AE A+I + +D +E E +
Sbjct: 2182 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2241
Query: 325 KRVREAESQYKPLLDKNKRLSR-KNEDLSHALRRMENKLKF---VTQENIEMRQRAGIIR 380
K+V E ++ + RL + EDL+ E LK QE ++ A +++
Sbjct: 2242 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2301
Query: 381 RPSSLNDLDQSQDEREVDFLKLQIVE-----QQNLIDELSKTLETAGYVKSVLER----- 430
+ L + + + + + Q+ E Q+ L E + LE + + + R
Sbjct: 2302 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2361
Query: 431 -------DKLLRFRKQ---------RKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQ 474
+ RFRKQ R ++A K +V+T +++ +++ +
Sbjct: 2362 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2421
Query: 475 TDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAY-----ALLQ-----EQVG 524
++ + L + ++E ++ QL E QALQ+++ +LLQ EQ
Sbjct: 2422 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2481
Query: 525 GTLDA--EREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMK--WIEEKQALYRRNQEL 580
L+ + EV +QL+ E QR Q ++E + L ++ + E ++ + R+ +EL
Sbjct: 2482 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2541
Query: 581 VEKIKQMETEEARLRHEVQDARDQNELLE 609
+ +Q +E L E Q R+Q +LLE
Sbjct: 2542 QQLEQQRRQQEELLAEENQRLREQLQLLE 2570
Score = 95.5 bits (236), Expect = 2e-19
Identities = 181/811 (22%), Positives = 336/811 (41%), Gaps = 113/811 (13%)
Query: 39 LQQEKSKVSKVEREKNQELRQVRE--HEQHKTAVLLTELKTKLHEEKMKELQAVRETLLR 96
+++E+ + E+ + L +V +Q + A + K + E + Q ++E ++R
Sbjct: 1312 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1371
Query: 97 QHEAELLRVIKIKDNENQR--LQALLSALRDGGPEKVKT-VLLSEAKEEAKKGFEVE--K 151
+ EA + D + Q+ +Q L LR +++ +EA E ++ E E
Sbjct: 1372 REEAAV-------DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1424
Query: 152 VKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRL 211
V++Q E +E + + E +QA + +A E + QEE R++++ + E +R
Sbjct: 1425 VRLQLEATERQRGGAEGE------LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR- 1477
Query: 212 MEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAA 271
K +A L + +A A+ Q +AL+E Q EA+R + E+ A
Sbjct: 1478 ------KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERAR 1529
Query: 272 GAGDASDHS-GSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREA 330
A + + S E +L K A F K A+L R L++ + +++ R E +R ++
Sbjct: 1530 QVQVALETAQRSAEAELQSKRA-SFAEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQ 1585
Query: 331 ESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQ 390
+ + + L R + ALR + + E+ Q+ + + + +
Sbjct: 1586 AEAERAREEAERELERWQLKANEALR--------LRLQAEEVAQQKSLAQAEAEKQKEEA 1637
Query: 391 SQDEREVDFLKLQIVEQQNLID-ELSKTLETA-GYVKSVLERD-KLLRFRKQRKKMAKLP 447
++ R + Q V Q+ L + EL K + A G + L + +L+R R
Sbjct: 1638 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR---------- 1687
Query: 448 KPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTM 507
ET G + LE + + + + Q ++E E ++
Sbjct: 1688 ----AETEQGEQQRQLLEEELARLQREAAAATQ-------------KRQELEAELAKVRA 1730
Query: 508 EYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLE--KALAEQGQDMK 565
E + L + A +E+ T + K++++L+AE R + E+ +ALAE+ + +
Sbjct: 1731 EMEVLLASKARAEEESRSTSE-----KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1785
Query: 566 WIEEKQALYRR---NQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEE----- 617
+ E+ A +R + L EK+ + E RL+ E + A + E R+ L E
Sbjct: 1786 QLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1844
Query: 618 RERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKL--DILGDNANLTNEEQV 675
R R + H + + L+ ++E E K L D L + EE++
Sbjct: 1845 RRRLEEQAAQHKADIEERLAQLRKASDSE-------LERQKGLVEDTLRQRRQV--EEEI 1895
Query: 676 VVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQ 735
+ ++A A K E L+ + +E L SK++ L E ++Q +
Sbjct: 1896 LALKASFEKAAAGK-------AELELELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAE 1946
Query: 736 ANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILR 795
+ E E + +L E A + EE E+LK VE+ +R LRER Q
Sbjct: 1947 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR-----LRERAEQESA 2001
Query: 796 ERMELLQLAQQRIKELEERIEAQKRQIKELE 826
+++L Q A Q+ + EE+ A Q KE E
Sbjct: 2002 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2032
Score = 92.4 bits (228), Expect = 2e-18
Identities = 173/835 (20%), Positives = 335/835 (40%), Gaps = 121/835 (14%)
Query: 48 KVEREKNQELRQVREHEQ---HKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLR 104
+ E E+ ++ RQ+ E E + A T+ + +L E ++ +++A E LL
Sbjct: 1687 RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL-EAELAKVRAEMEVLLASKARAEEE 1745
Query: 105 VIKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGA 164
+ QRL+A R+ E + L+E + ++ E + + + E A
Sbjct: 1746 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE------A 1799
Query: 165 KRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECERE-IRRLMEEIKFKDRAVF 223
+R + E L + +A ++K + EI +KE E E +RRL E+ F+ R +
Sbjct: 1800 ERVLAEKLAAIGEATRLKT----------EAEIALKEKEAENERLRRLAEDEAFQRRRLE 1849
Query: 224 ---------VLERELGVQAGHAQRLQLQKEALDEQLSQVREADRH------------PGS 262
+ ER ++ L+ QK +++ L Q R+ + G
Sbjct: 1850 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1909
Query: 263 PRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEER-N 321
EL +A D S EQ E +A R + AE E+R +EER
Sbjct: 1910 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAE--------EERRRREAEERVQ 1959
Query: 322 ELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRR 381
+ L EA Q K L++ +RL K E+ RR+ + + + +++ Q A R
Sbjct: 1960 KSLAAEEEAARQRKAALEEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRL 2015
Query: 382 PSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKL------LR 435
+ + ++E + L+ + ++Q+++D+L E A E ++ +
Sbjct: 2016 QAEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2074
Query: 436 FRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAK 495
R+Q ++ +L + + +A+ E + R Q + A+
Sbjct: 2075 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2134
Query: 496 EETELRFRQLTMEYQA-LQRAYALLQEQVGGT---------------LDAEREVKTREQL 539
E +F + T+ +A +++ L+ Q+ T +A + R Q+
Sbjct: 2135 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2194
Query: 540 QAEVQRAQARIEDLEKALA--EQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHE 597
+ E+ + ++E+L K A E + +K R QE EK+KQ+ E ARL
Sbjct: 2195 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2254
Query: 598 VQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELM 657
Q+A +L E + + K K +Q EA L
Sbjct: 2255 AQEAARLRQLAEEDLAQQRALAEKML------------KEKMQAVQEA--------TRLK 2294
Query: 658 KKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSK 717
+ ++L L E QAR + E+ QQ+ E QR + + E +++L
Sbjct: 2295 AEAELLQQQKELAQE------QARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQLEMS 2347
Query: 718 QKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKV--AELLSEEEREKLKVAV 775
+ E L R + +A E +A + +E G K+ EL ++E KV +
Sbjct: 2348 AEA---ERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQE-----KVTL 2398
Query: 776 EQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEKFL 830
Q ++ + + DA+ LRE + L+ ++++++ + ++ + +++ ++++ L
Sbjct: 2399 VQ-TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2452
Score = 83.6 bits (205), Expect = 7e-16
Identities = 184/880 (20%), Positives = 364/880 (41%), Gaps = 107/880 (12%)
Query: 10 AKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTA 69
A+ +K AL A LR++L +L+Q +S +S + EK + + V Q
Sbjct: 1013 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS-LSAIYLEKLKTISLVIRGTQGAEE 1071
Query: 70 VLLTELKTKLHEEKMKELQAVRETL--LRQHEAELLRVIKIKDNENQRLQALLSALRDGG 127
VL + HEE++KE QAV TL L +A L ++ + + AL LR G
Sbjct: 1072 VL------RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR--G 1123
Query: 128 PEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIR 187
++V E ++ +VE + ++ +++L +E ++ Q D ++ E+
Sbjct: 1124 AQEV-----GERLQQRHGERDVEVERWRERVAQL------LERWQAVLAQTD-VRQRELE 1171
Query: 188 SV---YHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERE--------LGVQAGHA 236
+ ++E + + + RR E+I+ A RE L H
Sbjct: 1172 QLGRQLRYYRESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1230
Query: 237 QRLQLQKEALDEQLSQVREADRHPGSPRREL-PHAAGAGDASDHSGSPEQQLDEKDARRF 295
++++ + + ++ +++ + + + +L P A+ A SGS + D R
Sbjct: 1231 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1290
Query: 296 QLKIAEL--------SAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRK 347
++ L S +R++E+ L ++R E +R+ E E+ L+K ++L+
Sbjct: 1291 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA----ALEKQRQLAEA 1346
Query: 348 NEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQ 407
+ R +L+ QE + R+ A + + + ++ Q R+ ++Q +
Sbjct: 1347 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1406
Query: 408 QNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESD 467
Q E S+ + E +++R + + + + ++ EEA E+
Sbjct: 1407 QAEAAERSRL--------RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA--EAQ 1456
Query: 468 GSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTL 527
+ +R + D+ + A+ E R + + QRA L+E
Sbjct: 1457 KRQAQEEAERLRRQ--VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1514
Query: 528 DAER-----EVKTREQLQAEVQRAQ----ARIEDLEKALAEQ-GQDMKWIEEKQALYRRN 577
+AER EV+ Q+Q ++ AQ A ++ + AE+ Q + ++E+ +
Sbjct: 1515 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1574
Query: 578 QELVEKIKQMETEEARLRHEVQDARDQ-----NELLEFRILELEERERKSPAISFHHTPF 632
+E E+ Q + E R R E + ++ NE L R+ E ++KS A +
Sbjct: 1575 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1634
Query: 633 VDGKSPLQVYCEAEGVT----DIVVAELMKKLDILGDNA--NLTNEEQVVVIQART---- 682
+ + + +AE ++ EL K+ + A L E++++ ++A T
Sbjct: 1635 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1694
Query: 683 -VLTLAEKWLQQIEETEAALQRKMVDLE-------SEKELFSKQKGYLDEELDYRKQALD 734
L E+ L +++ AA +K +LE +E E+ K +EE ++
Sbjct: 1695 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE----SRSTS 1750
Query: 735 QANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQIL 794
+ +K LE EA + L +EA A L+EE + + ++A E RQ R ++L
Sbjct: 1751 EKSKQRLEAEAGRFRELAEEAARLRA--LAEEAKRQRQLAEEDAARQ-----RAEAERVL 1803
Query: 795 RERMELLQLAQQRIKELE---ERIEAQKRQIKELEEKFLF 831
E++ + A + E E + EA+ +++ L E F
Sbjct: 1804 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1843
Score = 45.8 bits (107), Expect = 2e-04
Identities = 71/344 (20%), Positives = 142/344 (41%), Gaps = 61/344 (17%)
Query: 16 EALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLT-- 73
E L + A ++ + ++I+ QQ ++ RE EL + +E Q + +L
Sbjct: 2383 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL-REAIAELEREKEKLQQEAKLLQLKS 2441
Query: 74 -ELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVK 132
E++T E+ ++E QA++++ L + ++ LL+ + + E +L+ L E K
Sbjct: 2442 EEMQTVQQEQLLQETQALQQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ------DEVAK 2494
Query: 133 TVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHL 192
L E ++ ++ E E+ ++ + E + + + EE +
Sbjct: 2495 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------------------RR 2536
Query: 193 HQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQ--- 249
QEE+ +++++ RR EE+ ++ QRL+ Q + L+EQ
Sbjct: 2537 KQEELQQLEQQ-----RRQQEELLAEEN----------------QRLREQLQLLEEQHRA 2575
Query: 250 -LSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLD----EKDARRFQLKIAELSA 304
L+ E + + LP+ A D PE D + A+R Q +
Sbjct: 2576 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2635
Query: 305 IIRKLEDRNALLSE-ERNELLKRVREAESQYKPLLDK--NKRLS 345
+++L + + E R E ++ + S LL K N++LS
Sbjct: 2636 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLS 2679
Score = 41.2 bits (95), Expect = 0.004
Identities = 71/329 (21%), Positives = 130/329 (39%), Gaps = 40/329 (12%)
Query: 507 MEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKW 566
+ +Q+L+R L++ T + + R+ L + QA + D + A +D
Sbjct: 862 LAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 921
Query: 567 IE-EKQALYRRNQELVEKIKQMETEEARLRH---EVQDARDQNELLEFRI-------LEL 615
E E + Q+L++ ++Q EE+R + E++D R Q E E R L+
Sbjct: 922 AEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 981
Query: 616 EERERKSPAISFHHTPFVD----GKSPLQVYCEAEGVTDI-----VVAELMKKLDILGDN 666
E + I+ + GK ++ EAE V + L +L++
Sbjct: 982 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1041
Query: 667 ANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEEL 726
+ ++ ++L + Q EE A + ++ + ++ EL
Sbjct: 1042 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL--------PEL 1093
Query: 727 DYRKQALDQANKHILELEAMLYDALQQE--AGAKVAELLSEEEREKLKVAVEQWKRQVMS 784
+ K +L + E + +DAL+ E +V E L + E+ V VE+W
Sbjct: 1094 EATKASLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERW------ 1145
Query: 785 ELRERDAQILRERMELLQLAQQRIKELEE 813
RER AQ+L +L R +ELE+
Sbjct: 1146 --RERVAQLLERWQAVLAQTDVRQRELEQ 1172
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 103 bits (257), Expect = 7e-22
Identities = 181/859 (21%), Positives = 360/859 (41%), Gaps = 102/859 (11%)
Query: 16 EALAALQAANEDLRAKLTDIQIELQ---QEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
EA AA Q E L A+L ++ E++ K++ + R +++ +Q E E + L
Sbjct: 1879 EAAAATQKRQE-LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1937
Query: 73 TELKT--KLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEK 130
E L EE ++ Q E RQ AE RV+ ++L A+ A R +
Sbjct: 1938 EEAARLRALAEEAKRQRQLAEEDAARQR-AEAERVLA------EKLAAIGEATRLKTEAE 1990
Query: 131 VKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVY 190
+ E ++ E E + ++ + K +EE L + +A + + +
Sbjct: 1991 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 2050
Query: 191 HLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQL 250
E+ R +++ E EI L + LE ELG +A+ KE + +
Sbjct: 2051 ----EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 2106
Query: 251 SQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLE 310
++ R+ RRE A++ + +++ ++ R + K+ E + + E
Sbjct: 2107 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2166
Query: 311 DRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENI 370
+A + E ++ +AE + + +K ++L L++ ++ L
Sbjct: 2167 QESARQLQLAQEAAQKRLQAEEKAHAF-----AVQQKEQELQQTLQQEQSVLD------- 2214
Query: 371 EMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLER 430
++R A RR + + + Q ERE + Q+ E + L + + ++ E+
Sbjct: 2215 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2274
Query: 431 -----DKLLRFRKQRKKMAKLPKPVV---VETFFGYDEE-----ASLESDGSSVSYQTDR 477
++ R Q ++ A K +E + E+ A +E + +++ Q +
Sbjct: 2275 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2334
Query: 478 TDQTPCTPDDDL--------EEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDA 529
TD D++L E + + E + ++ + L + A ++ + +
Sbjct: 2335 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2394
Query: 530 EREVKTREQLQAEVQRAQARIED---LEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQ 586
+++ T+ LQ E ++ + E+ L A E + + EE A R E + K K
Sbjct: 2395 DKD-NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2453
Query: 587 METEEA-RLRHEVQDARDQNELLEFRILEL-EERERKSPAIS-----FHHTPFVDGKSPL 639
+EA RL+ E + + Q EL + + L E++E+ + ++ F T + + L
Sbjct: 2454 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2513
Query: 640 QVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEA 699
++ EAE + + VAE+ + A EE A+++ +Q EE
Sbjct: 2514 EMSAEAERL-KLRVAEMSR--------AQARAEED------------AQRFRKQAEEIGE 2552
Query: 700 ALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAML---YDALQQEAG 756
L R EL +++K L + L+ ++Q D + + E A L + LQQE
Sbjct: 2553 KLHR--------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE-- 2602
Query: 757 AKVAELLSEE----EREKLKVAVEQWKRQVMSE---LRERDAQILRERMELLQLAQQRIK 809
AK+ +L SEE ++E+L + ++ +SE L +R+ I +E+ +L QL Q +
Sbjct: 2603 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2662
Query: 810 ELEERIEAQKRQIKELEEK 828
+ ++ E Q+RQ +++E++
Sbjct: 2663 KAQQLREEQQRQQQQMEQE 2681
Score = 95.9 bits (237), Expect = 1e-19
Identities = 150/689 (21%), Positives = 284/689 (41%), Gaps = 92/689 (13%)
Query: 9 RAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQ-ELRQVREHEQHK 67
R + E + AL+A+ E A ++++EL + +S R K Q EL R+ +
Sbjct: 2055 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ--- 2111
Query: 68 TAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRV--IKIKDNENQRLQALL----- 120
E + + EE++++ A E RQ +A L V +K K E +RL+
Sbjct: 2112 -LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2170
Query: 121 ---------SALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEA 171
+ R EK + + ++E ++ + E+ + Q E + A+R EEA
Sbjct: 2171 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2230
Query: 172 LTLVIQADKIKAAEIRSVYHLH----------------QEEITRIKKECEREIRRLMEEI 215
+QA++ A R V Q +++KE E+E R +
Sbjct: 2231 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2290
Query: 216 KFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLS----QVREADRHPGSPRRELPHA- 270
+ R + E+ A++ QK ++++L+ Q+ E D EL
Sbjct: 2291 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2350
Query: 271 AGAGDASDHSGSPEQQL-----DEKDARRFQLKI-AELSAIIRKLEDRNALLSEERNELL 324
A A +A+ E++L ++ + + +I AE A+I + +D +E E +
Sbjct: 2351 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2410
Query: 325 KRVREAESQYKPLLDKNKRLSR-KNEDLSHALRRMENKLKF---VTQENIEMRQRAGIIR 380
K+V E ++ + RL + EDL+ E LK QE ++ A +++
Sbjct: 2411 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2470
Query: 381 RPSSLNDLDQSQDEREVDFLKLQIVE-----QQNLIDELSKTLETAGYVKSVLER----- 430
+ L + + + + + Q+ E Q+ L E + LE + + + R
Sbjct: 2471 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2530
Query: 431 -------DKLLRFRKQ---------RKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQ 474
+ RFRKQ R ++A K +V+T +++ +++ +
Sbjct: 2531 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2590
Query: 475 TDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAY-----ALLQ-----EQVG 524
++ + L + ++E ++ QL E QALQ+++ +LLQ EQ
Sbjct: 2591 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2650
Query: 525 GTLDA--EREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMK--WIEEKQALYRRNQEL 580
L+ + EV +QL+ E QR Q ++E + L ++ + E ++ + R+ +EL
Sbjct: 2651 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2710
Query: 581 VEKIKQMETEEARLRHEVQDARDQNELLE 609
+ +Q +E L E Q R+Q +LLE
Sbjct: 2711 QQLEQQRRQQEELLAEENQRLREQLQLLE 2739
Score = 95.5 bits (236), Expect = 2e-19
Identities = 181/811 (22%), Positives = 336/811 (41%), Gaps = 113/811 (13%)
Query: 39 LQQEKSKVSKVEREKNQELRQVRE--HEQHKTAVLLTELKTKLHEEKMKELQAVRETLLR 96
+++E+ + E+ + L +V +Q + A + K + E + Q ++E ++R
Sbjct: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540
Query: 97 QHEAELLRVIKIKDNENQR--LQALLSALRDGGPEKVKT-VLLSEAKEEAKKGFEVE--K 151
+ EA + D + Q+ +Q L LR +++ +EA E ++ E E
Sbjct: 1541 REEAAV-------DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1593
Query: 152 VKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRL 211
V++Q E +E + + E +QA + +A E + QEE R++++ + E +R
Sbjct: 1594 VRLQLEATERQRGGAEGE------LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR- 1646
Query: 212 MEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAA 271
K +A L + +A A+ Q +AL+E Q EA+R + E+ A
Sbjct: 1647 ------KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERAR 1698
Query: 272 GAGDASDHS-GSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREA 330
A + + S E +L K A F K A+L R L++ + +++ R E +R ++
Sbjct: 1699 QVQVALETAQRSAEAELQSKRA-SFAEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQ 1754
Query: 331 ESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQ 390
+ + + L R + ALR + + E+ Q+ + + + +
Sbjct: 1755 AEAERAREEAERELERWQLKANEALR--------LRLQAEEVAQQKSLAQAEAEKQKEEA 1806
Query: 391 SQDEREVDFLKLQIVEQQNLID-ELSKTLETA-GYVKSVLERD-KLLRFRKQRKKMAKLP 447
++ R + Q V Q+ L + EL K + A G + L + +L+R R
Sbjct: 1807 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR---------- 1856
Query: 448 KPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTM 507
ET G + LE + + + + Q ++E E ++
Sbjct: 1857 ----AETEQGEQQRQLLEEELARLQREAAAATQ-------------KRQELEAELAKVRA 1899
Query: 508 EYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLE--KALAEQGQDMK 565
E + L + A +E+ T + K++++L+AE R + E+ +ALAE+ + +
Sbjct: 1900 EMEVLLASKARAEEESRSTSE-----KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1954
Query: 566 WIEEKQALYRR---NQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEE----- 617
+ E+ A +R + L EK+ + E RL+ E + A + E R+ L E
Sbjct: 1955 QLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 2013
Query: 618 RERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKL--DILGDNANLTNEEQV 675
R R + H + + L+ ++E E K L D L + EE++
Sbjct: 2014 RRRLEEQAAQHKADIEERLAQLRKASDSE-------LERQKGLVEDTLRQRRQV--EEEI 2064
Query: 676 VVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQ 735
+ ++A A K E L+ + +E L SK++ L E ++Q +
Sbjct: 2065 LALKASFEKAAAGK-------AELELELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAE 2115
Query: 736 ANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILR 795
+ E E + +L E A + EE E+LK VE+ +R LRER Q
Sbjct: 2116 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR-----LRERAEQESA 2170
Query: 796 ERMELLQLAQQRIKELEERIEAQKRQIKELE 826
+++L Q A Q+ + EE+ A Q KE E
Sbjct: 2171 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2201
Score = 92.4 bits (228), Expect = 2e-18
Identities = 173/835 (20%), Positives = 335/835 (40%), Gaps = 121/835 (14%)
Query: 48 KVEREKNQELRQVREHEQ---HKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLR 104
+ E E+ ++ RQ+ E E + A T+ + +L E ++ +++A E LL
Sbjct: 1856 RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL-EAELAKVRAEMEVLLASKARAEEE 1914
Query: 105 VIKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGA 164
+ QRL+A R+ E + L+E + ++ E + + + E A
Sbjct: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE------A 1968
Query: 165 KRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECERE-IRRLMEEIKFKDRAVF 223
+R + E L + +A ++K + EI +KE E E +RRL E+ F+ R +
Sbjct: 1969 ERVLAEKLAAIGEATRLKT----------EAEIALKEKEAENERLRRLAEDEAFQRRRLE 2018
Query: 224 ---------VLERELGVQAGHAQRLQLQKEALDEQLSQVREADRH------------PGS 262
+ ER ++ L+ QK +++ L Q R+ + G
Sbjct: 2019 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 2078
Query: 263 PRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEER-N 321
EL +A D S EQ E +A R + AE E+R +EER
Sbjct: 2079 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAE--------EERRRREAEERVQ 2128
Query: 322 ELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRR 381
+ L EA Q K L++ +RL K E+ RR+ + + + +++ Q A R
Sbjct: 2129 KSLAAEEEAARQRKAALEEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRL 2184
Query: 382 PSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKL------LR 435
+ + ++E + L+ + ++Q+++D+L E A E ++ +
Sbjct: 2185 QAEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2243
Query: 436 FRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAK 495
R+Q ++ +L + + +A+ E + R Q + A+
Sbjct: 2244 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2303
Query: 496 EETELRFRQLTMEYQA-LQRAYALLQEQVGGT---------------LDAEREVKTREQL 539
E +F + T+ +A +++ L+ Q+ T +A + R Q+
Sbjct: 2304 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2363
Query: 540 QAEVQRAQARIEDLEKALA--EQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHE 597
+ E+ + ++E+L K A E + +K R QE EK+KQ+ E ARL
Sbjct: 2364 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2423
Query: 598 VQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELM 657
Q+A +L E + + K K +Q EA L
Sbjct: 2424 AQEAARLRQLAEEDLAQQRALAEKML------------KEKMQAVQEA--------TRLK 2463
Query: 658 KKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSK 717
+ ++L L E QAR + E+ QQ+ E QR + + E +++L
Sbjct: 2464 AEAELLQQQKELAQE------QARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQLEMS 2516
Query: 718 QKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKV--AELLSEEEREKLKVAV 775
+ E L R + +A E +A + +E G K+ EL ++E KV +
Sbjct: 2517 AEA---ERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQE-----KVTL 2567
Query: 776 EQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEKFL 830
Q ++ + + DA+ LRE + L+ ++++++ + ++ + +++ ++++ L
Sbjct: 2568 VQ-TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2621
Score = 83.6 bits (205), Expect = 7e-16
Identities = 184/880 (20%), Positives = 364/880 (41%), Gaps = 107/880 (12%)
Query: 10 AKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTA 69
A+ +K AL A LR++L +L+Q +S +S + EK + + V Q
Sbjct: 1182 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS-LSAIYLEKLKTISLVIRGTQGAEE 1240
Query: 70 VLLTELKTKLHEEKMKELQAVRETL--LRQHEAELLRVIKIKDNENQRLQALLSALRDGG 127
VL + HEE++KE QAV TL L +A L ++ + + AL LR G
Sbjct: 1241 VL------RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR--G 1292
Query: 128 PEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIR 187
++V E ++ +VE + ++ +++L +E ++ Q D ++ E+
Sbjct: 1293 AQEV-----GERLQQRHGERDVEVERWRERVAQL------LERWQAVLAQTD-VRQRELE 1340
Query: 188 SV---YHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERE--------LGVQAGHA 236
+ ++E + + + RR E+I+ A RE L H
Sbjct: 1341 QLGRQLRYYRESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1399
Query: 237 QRLQLQKEALDEQLSQVREADRHPGSPRREL-PHAAGAGDASDHSGSPEQQLDEKDARRF 295
++++ + + ++ +++ + + + +L P A+ A SGS + D R
Sbjct: 1400 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1459
Query: 296 QLKIAEL--------SAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRK 347
++ L S +R++E+ L ++R E +R+ E E+ L+K ++L+
Sbjct: 1460 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA----ALEKQRQLAEA 1515
Query: 348 NEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQ 407
+ R +L+ QE + R+ A + + + ++ Q R+ ++Q +
Sbjct: 1516 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1575
Query: 408 QNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESD 467
Q E S+ + E +++R + + + + ++ EEA E+
Sbjct: 1576 QAEAAERSRL--------RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA--EAQ 1625
Query: 468 GSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTL 527
+ +R + D+ + A+ E R + + QRA L+E
Sbjct: 1626 KRQAQEEAERLRRQ--VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1683
Query: 528 DAER-----EVKTREQLQAEVQRAQ----ARIEDLEKALAEQ-GQDMKWIEEKQALYRRN 577
+AER EV+ Q+Q ++ AQ A ++ + AE+ Q + ++E+ +
Sbjct: 1684 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1743
Query: 578 QELVEKIKQMETEEARLRHEVQDARDQ-----NELLEFRILELEERERKSPAISFHHTPF 632
+E E+ Q + E R R E + ++ NE L R+ E ++KS A +
Sbjct: 1744 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1803
Query: 633 VDGKSPLQVYCEAEGVT----DIVVAELMKKLDILGDNA--NLTNEEQVVVIQART---- 682
+ + + +AE ++ EL K+ + A L E++++ ++A T
Sbjct: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863
Query: 683 -VLTLAEKWLQQIEETEAALQRKMVDLE-------SEKELFSKQKGYLDEELDYRKQALD 734
L E+ L +++ AA +K +LE +E E+ K +EE ++
Sbjct: 1864 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE----SRSTS 1919
Query: 735 QANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQIL 794
+ +K LE EA + L +EA A L+EE + + ++A E RQ R ++L
Sbjct: 1920 EKSKQRLEAEAGRFRELAEEAARLRA--LAEEAKRQRQLAEEDAARQ-----RAEAERVL 1972
Query: 795 RERMELLQLAQQRIKELE---ERIEAQKRQIKELEEKFLF 831
E++ + A + E E + EA+ +++ L E F
Sbjct: 1973 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 2012
Score = 45.8 bits (107), Expect = 2e-04
Identities = 71/344 (20%), Positives = 142/344 (41%), Gaps = 61/344 (17%)
Query: 16 EALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLT-- 73
E L + A ++ + ++I+ QQ ++ RE EL + +E Q + +L
Sbjct: 2552 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL-REAIAELEREKEKLQQEAKLLQLKS 2610
Query: 74 -ELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVK 132
E++T E+ ++E QA++++ L + ++ LL+ + + E +L+ L E K
Sbjct: 2611 EEMQTVQQEQLLQETQALQQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ------DEVAK 2663
Query: 133 TVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHL 192
L E ++ ++ E E+ ++ + E + + + EE +
Sbjct: 2664 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------------------RR 2705
Query: 193 HQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQ--- 249
QEE+ +++++ RR EE+ ++ QRL+ Q + L+EQ
Sbjct: 2706 KQEELQQLEQQ-----RRQQEELLAEEN----------------QRLREQLQLLEEQHRA 2744
Query: 250 -LSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLD----EKDARRFQLKIAELSA 304
L+ E + + LP+ A D PE D + A+R Q +
Sbjct: 2745 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2804
Query: 305 IIRKLEDRNALLSE-ERNELLKRVREAESQYKPLLDK--NKRLS 345
+++L + + E R E ++ + S LL K N++LS
Sbjct: 2805 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLS 2848
Score = 41.2 bits (95), Expect = 0.004
Identities = 71/329 (21%), Positives = 130/329 (39%), Gaps = 40/329 (12%)
Query: 507 MEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKW 566
+ +Q+L+R L++ T + + R+ L + QA + D + A +D
Sbjct: 1031 LAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 1090
Query: 567 IE-EKQALYRRNQELVEKIKQMETEEARLRH---EVQDARDQNELLEFRI-------LEL 615
E E + Q+L++ ++Q EE+R + E++D R Q E E R L+
Sbjct: 1091 AEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1150
Query: 616 EERERKSPAISFHHTPFVD----GKSPLQVYCEAEGVTDI-----VVAELMKKLDILGDN 666
E + I+ + GK ++ EAE V + L +L++
Sbjct: 1151 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1210
Query: 667 ANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEEL 726
+ ++ ++L + Q EE A + ++ + ++ EL
Sbjct: 1211 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL--------PEL 1262
Query: 727 DYRKQALDQANKHILELEAMLYDALQQE--AGAKVAELLSEEEREKLKVAVEQWKRQVMS 784
+ K +L + E + +DAL+ E +V E L + E+ V VE+W
Sbjct: 1263 EATKASLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERW------ 1314
Query: 785 ELRERDAQILRERMELLQLAQQRIKELEE 813
RER AQ+L +L R +ELE+
Sbjct: 1315 --RERVAQLLERWQAVLAQTDVRQRELEQ 1341
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 103 bits (257), Expect = 7e-22
Identities = 181/859 (21%), Positives = 360/859 (41%), Gaps = 102/859 (11%)
Query: 16 EALAALQAANEDLRAKLTDIQIELQ---QEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
EA AA Q E L A+L ++ E++ K++ + R +++ +Q E E + L
Sbjct: 1720 EAAAATQKRQE-LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1778
Query: 73 TELKT--KLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEK 130
E L EE ++ Q E RQ AE RV+ ++L A+ A R +
Sbjct: 1779 EEAARLRALAEEAKRQRQLAEEDAARQR-AEAERVLA------EKLAAIGEATRLKTEAE 1831
Query: 131 VKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVY 190
+ E ++ E E + ++ + K +EE L + +A + + +
Sbjct: 1832 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1891
Query: 191 HLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQL 250
E+ R +++ E EI L + LE ELG +A+ KE + +
Sbjct: 1892 ----EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1947
Query: 251 SQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLE 310
++ R+ RRE A++ + +++ ++ R + K+ E + + E
Sbjct: 1948 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2007
Query: 311 DRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENI 370
+A + E ++ +AE + + +K ++L L++ ++ L
Sbjct: 2008 QESARQLQLAQEAAQKRLQAEEKAHAF-----AVQQKEQELQQTLQQEQSVLD------- 2055
Query: 371 EMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLER 430
++R A RR + + + Q ERE + Q+ E + L + + ++ E+
Sbjct: 2056 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2115
Query: 431 -----DKLLRFRKQRKKMAKLPKPVV---VETFFGYDEE-----ASLESDGSSVSYQTDR 477
++ R Q ++ A K +E + E+ A +E + +++ Q +
Sbjct: 2116 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2175
Query: 478 TDQTPCTPDDDL--------EEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDA 529
TD D++L E + + E + ++ + L + A ++ + +
Sbjct: 2176 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2235
Query: 530 EREVKTREQLQAEVQRAQARIED---LEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQ 586
+++ T+ LQ E ++ + E+ L A E + + EE A R E + K K
Sbjct: 2236 DKD-NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2294
Query: 587 METEEA-RLRHEVQDARDQNELLEFRILEL-EERERKSPAIS-----FHHTPFVDGKSPL 639
+EA RL+ E + + Q EL + + L E++E+ + ++ F T + + L
Sbjct: 2295 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2354
Query: 640 QVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEA 699
++ EAE + + VAE+ + A EE A+++ +Q EE
Sbjct: 2355 EMSAEAERL-KLRVAEMSR--------AQARAEED------------AQRFRKQAEEIGE 2393
Query: 700 ALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAML---YDALQQEAG 756
L R EL +++K L + L+ ++Q D + + E A L + LQQE
Sbjct: 2394 KLHR--------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE-- 2443
Query: 757 AKVAELLSEE----EREKLKVAVEQWKRQVMSE---LRERDAQILRERMELLQLAQQRIK 809
AK+ +L SEE ++E+L + ++ +SE L +R+ I +E+ +L QL Q +
Sbjct: 2444 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2503
Query: 810 ELEERIEAQKRQIKELEEK 828
+ ++ E Q+RQ +++E++
Sbjct: 2504 KAQQLREEQQRQQQQMEQE 2522
Score = 95.9 bits (237), Expect = 1e-19
Identities = 150/689 (21%), Positives = 284/689 (41%), Gaps = 92/689 (13%)
Query: 9 RAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQ-ELRQVREHEQHK 67
R + E + AL+A+ E A ++++EL + +S R K Q EL R+ +
Sbjct: 1896 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ--- 1952
Query: 68 TAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRV--IKIKDNENQRLQALL----- 120
E + + EE++++ A E RQ +A L V +K K E +RL+
Sbjct: 1953 -LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2011
Query: 121 ---------SALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEA 171
+ R EK + + ++E ++ + E+ + Q E + A+R EEA
Sbjct: 2012 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2071
Query: 172 LTLVIQADKIKAAEIRSVYHLH----------------QEEITRIKKECEREIRRLMEEI 215
+QA++ A R V Q +++KE E+E R +
Sbjct: 2072 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2131
Query: 216 KFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLS----QVREADRHPGSPRRELPHA- 270
+ R + E+ A++ QK ++++L+ Q+ E D EL
Sbjct: 2132 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2191
Query: 271 AGAGDASDHSGSPEQQL-----DEKDARRFQLKI-AELSAIIRKLEDRNALLSEERNELL 324
A A +A+ E++L ++ + + +I AE A+I + +D +E E +
Sbjct: 2192 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2251
Query: 325 KRVREAESQYKPLLDKNKRLSR-KNEDLSHALRRMENKLKF---VTQENIEMRQRAGIIR 380
K+V E ++ + RL + EDL+ E LK QE ++ A +++
Sbjct: 2252 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2311
Query: 381 RPSSLNDLDQSQDEREVDFLKLQIVE-----QQNLIDELSKTLETAGYVKSVLER----- 430
+ L + + + + + Q+ E Q+ L E + LE + + + R
Sbjct: 2312 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2371
Query: 431 -------DKLLRFRKQ---------RKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQ 474
+ RFRKQ R ++A K +V+T +++ +++ +
Sbjct: 2372 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2431
Query: 475 TDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAY-----ALLQ-----EQVG 524
++ + L + ++E ++ QL E QALQ+++ +LLQ EQ
Sbjct: 2432 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2491
Query: 525 GTLDA--EREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMK--WIEEKQALYRRNQEL 580
L+ + EV +QL+ E QR Q ++E + L ++ + E ++ + R+ +EL
Sbjct: 2492 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2551
Query: 581 VEKIKQMETEEARLRHEVQDARDQNELLE 609
+ +Q +E L E Q R+Q +LLE
Sbjct: 2552 QQLEQQRRQQEELLAEENQRLREQLQLLE 2580
Score = 95.5 bits (236), Expect = 2e-19
Identities = 181/811 (22%), Positives = 336/811 (41%), Gaps = 113/811 (13%)
Query: 39 LQQEKSKVSKVEREKNQELRQVRE--HEQHKTAVLLTELKTKLHEEKMKELQAVRETLLR 96
+++E+ + E+ + L +V +Q + A + K + E + Q ++E ++R
Sbjct: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381
Query: 97 QHEAELLRVIKIKDNENQR--LQALLSALRDGGPEKVKT-VLLSEAKEEAKKGFEVE--K 151
+ EA + D + Q+ +Q L LR +++ +EA E ++ E E
Sbjct: 1382 REEAAV-------DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1434
Query: 152 VKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRL 211
V++Q E +E + + E +QA + +A E + QEE R++++ + E +R
Sbjct: 1435 VRLQLEATERQRGGAEGE------LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR- 1487
Query: 212 MEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAA 271
K +A L + +A A+ Q +AL+E Q EA+R + E+ A
Sbjct: 1488 ------KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERAR 1539
Query: 272 GAGDASDHS-GSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREA 330
A + + S E +L K A F K A+L R L++ + +++ R E +R ++
Sbjct: 1540 QVQVALETAQRSAEAELQSKRA-SFAEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQ 1595
Query: 331 ESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQ 390
+ + + L R + ALR + + E+ Q+ + + + +
Sbjct: 1596 AEAERAREEAERELERWQLKANEALR--------LRLQAEEVAQQKSLAQAEAEKQKEEA 1647
Query: 391 SQDEREVDFLKLQIVEQQNLID-ELSKTLETA-GYVKSVLERD-KLLRFRKQRKKMAKLP 447
++ R + Q V Q+ L + EL K + A G + L + +L+R R
Sbjct: 1648 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR---------- 1697
Query: 448 KPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTM 507
ET G + LE + + + + Q ++E E ++
Sbjct: 1698 ----AETEQGEQQRQLLEEELARLQREAAAATQ-------------KRQELEAELAKVRA 1740
Query: 508 EYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLE--KALAEQGQDMK 565
E + L + A +E+ T + K++++L+AE R + E+ +ALAE+ + +
Sbjct: 1741 EMEVLLASKARAEEESRSTSE-----KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1795
Query: 566 WIEEKQALYRR---NQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEE----- 617
+ E+ A +R + L EK+ + E RL+ E + A + E R+ L E
Sbjct: 1796 QLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1854
Query: 618 RERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKL--DILGDNANLTNEEQV 675
R R + H + + L+ ++E E K L D L + EE++
Sbjct: 1855 RRRLEEQAAQHKADIEERLAQLRKASDSE-------LERQKGLVEDTLRQRRQV--EEEI 1905
Query: 676 VVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQ 735
+ ++A A K E L+ + +E L SK++ L E ++Q +
Sbjct: 1906 LALKASFEKAAAGK-------AELELELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAE 1956
Query: 736 ANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILR 795
+ E E + +L E A + EE E+LK VE+ +R LRER Q
Sbjct: 1957 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR-----LRERAEQESA 2011
Query: 796 ERMELLQLAQQRIKELEERIEAQKRQIKELE 826
+++L Q A Q+ + EE+ A Q KE E
Sbjct: 2012 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2042
Score = 92.4 bits (228), Expect = 2e-18
Identities = 173/835 (20%), Positives = 335/835 (40%), Gaps = 121/835 (14%)
Query: 48 KVEREKNQELRQVREHEQ---HKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLR 104
+ E E+ ++ RQ+ E E + A T+ + +L E ++ +++A E LL
Sbjct: 1697 RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL-EAELAKVRAEMEVLLASKARAEEE 1755
Query: 105 VIKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGA 164
+ QRL+A R+ E + L+E + ++ E + + + E A
Sbjct: 1756 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE------A 1809
Query: 165 KRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECERE-IRRLMEEIKFKDRAVF 223
+R + E L + +A ++K + EI +KE E E +RRL E+ F+ R +
Sbjct: 1810 ERVLAEKLAAIGEATRLKT----------EAEIALKEKEAENERLRRLAEDEAFQRRRLE 1859
Query: 224 ---------VLERELGVQAGHAQRLQLQKEALDEQLSQVREADRH------------PGS 262
+ ER ++ L+ QK +++ L Q R+ + G
Sbjct: 1860 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1919
Query: 263 PRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEER-N 321
EL +A D S EQ E +A R + AE E+R +EER
Sbjct: 1920 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAE--------EERRRREAEERVQ 1969
Query: 322 ELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRR 381
+ L EA Q K L++ +RL K E+ RR+ + + + +++ Q A R
Sbjct: 1970 KSLAAEEEAARQRKAALEEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRL 2025
Query: 382 PSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKL------LR 435
+ + ++E + L+ + ++Q+++D+L E A E ++ +
Sbjct: 2026 QAEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2084
Query: 436 FRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAK 495
R+Q ++ +L + + +A+ E + R Q + A+
Sbjct: 2085 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2144
Query: 496 EETELRFRQLTMEYQA-LQRAYALLQEQVGGT---------------LDAEREVKTREQL 539
E +F + T+ +A +++ L+ Q+ T +A + R Q+
Sbjct: 2145 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2204
Query: 540 QAEVQRAQARIEDLEKALA--EQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHE 597
+ E+ + ++E+L K A E + +K R QE EK+KQ+ E ARL
Sbjct: 2205 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2264
Query: 598 VQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELM 657
Q+A +L E + + K K +Q EA L
Sbjct: 2265 AQEAARLRQLAEEDLAQQRALAEKML------------KEKMQAVQEA--------TRLK 2304
Query: 658 KKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSK 717
+ ++L L E QAR + E+ QQ+ E QR + + E +++L
Sbjct: 2305 AEAELLQQQKELAQE------QARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQLEMS 2357
Query: 718 QKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKV--AELLSEEEREKLKVAV 775
+ E L R + +A E +A + +E G K+ EL ++E KV +
Sbjct: 2358 AEA---ERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQE-----KVTL 2408
Query: 776 EQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEKFL 830
Q ++ + + DA+ LRE + L+ ++++++ + ++ + +++ ++++ L
Sbjct: 2409 VQ-TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2462
Score = 83.6 bits (205), Expect = 7e-16
Identities = 184/880 (20%), Positives = 364/880 (41%), Gaps = 107/880 (12%)
Query: 10 AKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTA 69
A+ +K AL A LR++L +L+Q +S +S + EK + + V Q
Sbjct: 1023 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS-LSAIYLEKLKTISLVIRGTQGAEE 1081
Query: 70 VLLTELKTKLHEEKMKELQAVRETL--LRQHEAELLRVIKIKDNENQRLQALLSALRDGG 127
VL + HEE++KE QAV TL L +A L ++ + + AL LR G
Sbjct: 1082 VL------RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR--G 1133
Query: 128 PEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIR 187
++V E ++ +VE + ++ +++L +E ++ Q D ++ E+
Sbjct: 1134 AQEV-----GERLQQRHGERDVEVERWRERVAQL------LERWQAVLAQTD-VRQRELE 1181
Query: 188 SV---YHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERE--------LGVQAGHA 236
+ ++E + + + RR E+I+ A RE L H
Sbjct: 1182 QLGRQLRYYRESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1240
Query: 237 QRLQLQKEALDEQLSQVREADRHPGSPRREL-PHAAGAGDASDHSGSPEQQLDEKDARRF 295
++++ + + ++ +++ + + + +L P A+ A SGS + D R
Sbjct: 1241 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1300
Query: 296 QLKIAEL--------SAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRK 347
++ L S +R++E+ L ++R E +R+ E E+ L+K ++L+
Sbjct: 1301 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA----ALEKQRQLAEA 1356
Query: 348 NEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQ 407
+ R +L+ QE + R+ A + + + ++ Q R+ ++Q +
Sbjct: 1357 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1416
Query: 408 QNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESD 467
Q E S+ + E +++R + + + + ++ EEA E+
Sbjct: 1417 QAEAAERSRL--------RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA--EAQ 1466
Query: 468 GSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTL 527
+ +R + D+ + A+ E R + + QRA L+E
Sbjct: 1467 KRQAQEEAERLRRQ--VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1524
Query: 528 DAER-----EVKTREQLQAEVQRAQ----ARIEDLEKALAEQ-GQDMKWIEEKQALYRRN 577
+AER EV+ Q+Q ++ AQ A ++ + AE+ Q + ++E+ +
Sbjct: 1525 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1584
Query: 578 QELVEKIKQMETEEARLRHEVQDARDQ-----NELLEFRILELEERERKSPAISFHHTPF 632
+E E+ Q + E R R E + ++ NE L R+ E ++KS A +
Sbjct: 1585 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1644
Query: 633 VDGKSPLQVYCEAEGVT----DIVVAELMKKLDILGDNA--NLTNEEQVVVIQART---- 682
+ + + +AE ++ EL K+ + A L E++++ ++A T
Sbjct: 1645 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704
Query: 683 -VLTLAEKWLQQIEETEAALQRKMVDLE-------SEKELFSKQKGYLDEELDYRKQALD 734
L E+ L +++ AA +K +LE +E E+ K +EE ++
Sbjct: 1705 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE----SRSTS 1760
Query: 735 QANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQIL 794
+ +K LE EA + L +EA A L+EE + + ++A E RQ R ++L
Sbjct: 1761 EKSKQRLEAEAGRFRELAEEAARLRA--LAEEAKRQRQLAEEDAARQ-----RAEAERVL 1813
Query: 795 RERMELLQLAQQRIKELE---ERIEAQKRQIKELEEKFLF 831
E++ + A + E E + EA+ +++ L E F
Sbjct: 1814 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1853
Score = 45.8 bits (107), Expect = 2e-04
Identities = 71/344 (20%), Positives = 142/344 (41%), Gaps = 61/344 (17%)
Query: 16 EALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLT-- 73
E L + A ++ + ++I+ QQ ++ RE EL + +E Q + +L
Sbjct: 2393 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL-REAIAELEREKEKLQQEAKLLQLKS 2451
Query: 74 -ELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVK 132
E++T E+ ++E QA++++ L + ++ LL+ + + E +L+ L E K
Sbjct: 2452 EEMQTVQQEQLLQETQALQQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ------DEVAK 2504
Query: 133 TVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHL 192
L E ++ ++ E E+ ++ + E + + + EE +
Sbjct: 2505 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------------------RR 2546
Query: 193 HQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQ--- 249
QEE+ +++++ RR EE+ ++ QRL+ Q + L+EQ
Sbjct: 2547 KQEELQQLEQQ-----RRQQEELLAEEN----------------QRLREQLQLLEEQHRA 2585
Query: 250 -LSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLD----EKDARRFQLKIAELSA 304
L+ E + + LP+ A D PE D + A+R Q +
Sbjct: 2586 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2645
Query: 305 IIRKLEDRNALLSE-ERNELLKRVREAESQYKPLLDK--NKRLS 345
+++L + + E R E ++ + S LL K N++LS
Sbjct: 2646 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLS 2689
Score = 41.2 bits (95), Expect = 0.004
Identities = 71/329 (21%), Positives = 130/329 (39%), Gaps = 40/329 (12%)
Query: 507 MEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKW 566
+ +Q+L+R L++ T + + R+ L + QA + D + A +D
Sbjct: 872 LAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 931
Query: 567 IE-EKQALYRRNQELVEKIKQMETEEARLRH---EVQDARDQNELLEFRI-------LEL 615
E E + Q+L++ ++Q EE+R + E++D R Q E E R L+
Sbjct: 932 AEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 991
Query: 616 EERERKSPAISFHHTPFVD----GKSPLQVYCEAEGVTDI-----VVAELMKKLDILGDN 666
E + I+ + GK ++ EAE V + L +L++
Sbjct: 992 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1051
Query: 667 ANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEEL 726
+ ++ ++L + Q EE A + ++ + ++ EL
Sbjct: 1052 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL--------PEL 1103
Query: 727 DYRKQALDQANKHILELEAMLYDALQQE--AGAKVAELLSEEEREKLKVAVEQWKRQVMS 784
+ K +L + E + +DAL+ E +V E L + E+ V VE+W
Sbjct: 1104 EATKASLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERW------ 1155
Query: 785 ELRERDAQILRERMELLQLAQQRIKELEE 813
RER AQ+L +L R +ELE+
Sbjct: 1156 --RERVAQLLERWQAVLAQTDVRQRELEQ 1182
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 103 bits (257), Expect = 7e-22
Identities = 181/859 (21%), Positives = 360/859 (41%), Gaps = 102/859 (11%)
Query: 16 EALAALQAANEDLRAKLTDIQIELQ---QEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
EA AA Q E L A+L ++ E++ K++ + R +++ +Q E E + L
Sbjct: 1728 EAAAATQKRQE-LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1786
Query: 73 TELKT--KLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEK 130
E L EE ++ Q E RQ AE RV+ ++L A+ A R +
Sbjct: 1787 EEAARLRALAEEAKRQRQLAEEDAARQR-AEAERVLA------EKLAAIGEATRLKTEAE 1839
Query: 131 VKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVY 190
+ E ++ E E + ++ + K +EE L + +A + + +
Sbjct: 1840 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1899
Query: 191 HLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQL 250
E+ R +++ E EI L + LE ELG +A+ KE + +
Sbjct: 1900 ----EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1955
Query: 251 SQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLE 310
++ R+ RRE A++ + +++ ++ R + K+ E + + E
Sbjct: 1956 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2015
Query: 311 DRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENI 370
+A + E ++ +AE + + +K ++L L++ ++ L
Sbjct: 2016 QESARQLQLAQEAAQKRLQAEEKAHAF-----AVQQKEQELQQTLQQEQSVLD------- 2063
Query: 371 EMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLER 430
++R A RR + + + Q ERE + Q+ E + L + + ++ E+
Sbjct: 2064 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2123
Query: 431 -----DKLLRFRKQRKKMAKLPKPVV---VETFFGYDEE-----ASLESDGSSVSYQTDR 477
++ R Q ++ A K +E + E+ A +E + +++ Q +
Sbjct: 2124 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2183
Query: 478 TDQTPCTPDDDL--------EEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDA 529
TD D++L E + + E + ++ + L + A ++ + +
Sbjct: 2184 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2243
Query: 530 EREVKTREQLQAEVQRAQARIED---LEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQ 586
+++ T+ LQ E ++ + E+ L A E + + EE A R E + K K
Sbjct: 2244 DKD-NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2302
Query: 587 METEEA-RLRHEVQDARDQNELLEFRILEL-EERERKSPAIS-----FHHTPFVDGKSPL 639
+EA RL+ E + + Q EL + + L E++E+ + ++ F T + + L
Sbjct: 2303 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2362
Query: 640 QVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEA 699
++ EAE + + VAE+ + A EE A+++ +Q EE
Sbjct: 2363 EMSAEAERL-KLRVAEMSR--------AQARAEED------------AQRFRKQAEEIGE 2401
Query: 700 ALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAML---YDALQQEAG 756
L R EL +++K L + L+ ++Q D + + E A L + LQQE
Sbjct: 2402 KLHR--------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE-- 2451
Query: 757 AKVAELLSEE----EREKLKVAVEQWKRQVMSE---LRERDAQILRERMELLQLAQQRIK 809
AK+ +L SEE ++E+L + ++ +SE L +R+ I +E+ +L QL Q +
Sbjct: 2452 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2511
Query: 810 ELEERIEAQKRQIKELEEK 828
+ ++ E Q+RQ +++E++
Sbjct: 2512 KAQQLREEQQRQQQQMEQE 2530
Score = 95.9 bits (237), Expect = 1e-19
Identities = 150/689 (21%), Positives = 284/689 (41%), Gaps = 92/689 (13%)
Query: 9 RAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQ-ELRQVREHEQHK 67
R + E + AL+A+ E A ++++EL + +S R K Q EL R+ +
Sbjct: 1904 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ--- 1960
Query: 68 TAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRV--IKIKDNENQRLQALL----- 120
E + + EE++++ A E RQ +A L V +K K E +RL+
Sbjct: 1961 -LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2019
Query: 121 ---------SALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEA 171
+ R EK + + ++E ++ + E+ + Q E + A+R EEA
Sbjct: 2020 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2079
Query: 172 LTLVIQADKIKAAEIRSVYHLH----------------QEEITRIKKECEREIRRLMEEI 215
+QA++ A R V Q +++KE E+E R +
Sbjct: 2080 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2139
Query: 216 KFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLS----QVREADRHPGSPRRELPHA- 270
+ R + E+ A++ QK ++++L+ Q+ E D EL
Sbjct: 2140 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2199
Query: 271 AGAGDASDHSGSPEQQL-----DEKDARRFQLKI-AELSAIIRKLEDRNALLSEERNELL 324
A A +A+ E++L ++ + + +I AE A+I + +D +E E +
Sbjct: 2200 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2259
Query: 325 KRVREAESQYKPLLDKNKRLSR-KNEDLSHALRRMENKLKF---VTQENIEMRQRAGIIR 380
K+V E ++ + RL + EDL+ E LK QE ++ A +++
Sbjct: 2260 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2319
Query: 381 RPSSLNDLDQSQDEREVDFLKLQIVE-----QQNLIDELSKTLETAGYVKSVLER----- 430
+ L + + + + + Q+ E Q+ L E + LE + + + R
Sbjct: 2320 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2379
Query: 431 -------DKLLRFRKQ---------RKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQ 474
+ RFRKQ R ++A K +V+T +++ +++ +
Sbjct: 2380 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2439
Query: 475 TDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAY-----ALLQ-----EQVG 524
++ + L + ++E ++ QL E QALQ+++ +LLQ EQ
Sbjct: 2440 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2499
Query: 525 GTLDA--EREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMK--WIEEKQALYRRNQEL 580
L+ + EV +QL+ E QR Q ++E + L ++ + E ++ + R+ +EL
Sbjct: 2500 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2559
Query: 581 VEKIKQMETEEARLRHEVQDARDQNELLE 609
+ +Q +E L E Q R+Q +LLE
Sbjct: 2560 QQLEQQRRQQEELLAEENQRLREQLQLLE 2588
Score = 95.5 bits (236), Expect = 2e-19
Identities = 181/811 (22%), Positives = 336/811 (41%), Gaps = 113/811 (13%)
Query: 39 LQQEKSKVSKVEREKNQELRQVRE--HEQHKTAVLLTELKTKLHEEKMKELQAVRETLLR 96
+++E+ + E+ + L +V +Q + A + K + E + Q ++E ++R
Sbjct: 1330 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1389
Query: 97 QHEAELLRVIKIKDNENQR--LQALLSALRDGGPEKVKT-VLLSEAKEEAKKGFEVE--K 151
+ EA + D + Q+ +Q L LR +++ +EA E ++ E E
Sbjct: 1390 REEAAV-------DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1442
Query: 152 VKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRL 211
V++Q E +E + + E +QA + +A E + QEE R++++ + E +R
Sbjct: 1443 VRLQLEATERQRGGAEGE------LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR- 1495
Query: 212 MEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAA 271
K +A L + +A A+ Q +AL+E Q EA+R + E+ A
Sbjct: 1496 ------KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERAR 1547
Query: 272 GAGDASDHS-GSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREA 330
A + + S E +L K A F K A+L R L++ + +++ R E +R ++
Sbjct: 1548 QVQVALETAQRSAEAELQSKRA-SFAEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQ 1603
Query: 331 ESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQ 390
+ + + L R + ALR + + E+ Q+ + + + +
Sbjct: 1604 AEAERAREEAERELERWQLKANEALR--------LRLQAEEVAQQKSLAQAEAEKQKEEA 1655
Query: 391 SQDEREVDFLKLQIVEQQNLID-ELSKTLETA-GYVKSVLERD-KLLRFRKQRKKMAKLP 447
++ R + Q V Q+ L + EL K + A G + L + +L+R R
Sbjct: 1656 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR---------- 1705
Query: 448 KPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTM 507
ET G + LE + + + + Q ++E E ++
Sbjct: 1706 ----AETEQGEQQRQLLEEELARLQREAAAATQ-------------KRQELEAELAKVRA 1748
Query: 508 EYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLE--KALAEQGQDMK 565
E + L + A +E+ T + K++++L+AE R + E+ +ALAE+ + +
Sbjct: 1749 EMEVLLASKARAEEESRSTSE-----KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1803
Query: 566 WIEEKQALYRR---NQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEE----- 617
+ E+ A +R + L EK+ + E RL+ E + A + E R+ L E
Sbjct: 1804 QLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1862
Query: 618 RERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKL--DILGDNANLTNEEQV 675
R R + H + + L+ ++E E K L D L + EE++
Sbjct: 1863 RRRLEEQAAQHKADIEERLAQLRKASDSE-------LERQKGLVEDTLRQRRQV--EEEI 1913
Query: 676 VVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQ 735
+ ++A A K E L+ + +E L SK++ L E ++Q +
Sbjct: 1914 LALKASFEKAAAGK-------AELELELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAE 1964
Query: 736 ANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILR 795
+ E E + +L E A + EE E+LK VE+ +R LRER Q
Sbjct: 1965 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR-----LRERAEQESA 2019
Query: 796 ERMELLQLAQQRIKELEERIEAQKRQIKELE 826
+++L Q A Q+ + EE+ A Q KE E
Sbjct: 2020 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2050
Score = 92.4 bits (228), Expect = 2e-18
Identities = 173/835 (20%), Positives = 335/835 (40%), Gaps = 121/835 (14%)
Query: 48 KVEREKNQELRQVREHEQ---HKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLR 104
+ E E+ ++ RQ+ E E + A T+ + +L E ++ +++A E LL
Sbjct: 1705 RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL-EAELAKVRAEMEVLLASKARAEEE 1763
Query: 105 VIKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGA 164
+ QRL+A R+ E + L+E + ++ E + + + E A
Sbjct: 1764 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE------A 1817
Query: 165 KRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECERE-IRRLMEEIKFKDRAVF 223
+R + E L + +A ++K + EI +KE E E +RRL E+ F+ R +
Sbjct: 1818 ERVLAEKLAAIGEATRLKT----------EAEIALKEKEAENERLRRLAEDEAFQRRRLE 1867
Query: 224 ---------VLERELGVQAGHAQRLQLQKEALDEQLSQVREADRH------------PGS 262
+ ER ++ L+ QK +++ L Q R+ + G
Sbjct: 1868 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1927
Query: 263 PRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEER-N 321
EL +A D S EQ E +A R + AE E+R +EER
Sbjct: 1928 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAE--------EERRRREAEERVQ 1977
Query: 322 ELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRR 381
+ L EA Q K L++ +RL K E+ RR+ + + + +++ Q A R
Sbjct: 1978 KSLAAEEEAARQRKAALEEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRL 2033
Query: 382 PSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKL------LR 435
+ + ++E + L+ + ++Q+++D+L E A E ++ +
Sbjct: 2034 QAEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2092
Query: 436 FRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAK 495
R+Q ++ +L + + +A+ E + R Q + A+
Sbjct: 2093 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2152
Query: 496 EETELRFRQLTMEYQA-LQRAYALLQEQVGGT---------------LDAEREVKTREQL 539
E +F + T+ +A +++ L+ Q+ T +A + R Q+
Sbjct: 2153 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2212
Query: 540 QAEVQRAQARIEDLEKALA--EQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHE 597
+ E+ + ++E+L K A E + +K R QE EK+KQ+ E ARL
Sbjct: 2213 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2272
Query: 598 VQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELM 657
Q+A +L E + + K K +Q EA L
Sbjct: 2273 AQEAARLRQLAEEDLAQQRALAEKML------------KEKMQAVQEA--------TRLK 2312
Query: 658 KKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSK 717
+ ++L L E QAR + E+ QQ+ E QR + + E +++L
Sbjct: 2313 AEAELLQQQKELAQE------QARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQLEMS 2365
Query: 718 QKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKV--AELLSEEEREKLKVAV 775
+ E L R + +A E +A + +E G K+ EL ++E KV +
Sbjct: 2366 AEA---ERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQE-----KVTL 2416
Query: 776 EQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEKFL 830
Q ++ + + DA+ LRE + L+ ++++++ + ++ + +++ ++++ L
Sbjct: 2417 VQ-TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2470
Score = 83.6 bits (205), Expect = 7e-16
Identities = 184/880 (20%), Positives = 364/880 (41%), Gaps = 107/880 (12%)
Query: 10 AKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTA 69
A+ +K AL A LR++L +L+Q +S +S + EK + + V Q
Sbjct: 1031 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS-LSAIYLEKLKTISLVIRGTQGAEE 1089
Query: 70 VLLTELKTKLHEEKMKELQAVRETL--LRQHEAELLRVIKIKDNENQRLQALLSALRDGG 127
VL + HEE++KE QAV TL L +A L ++ + + AL LR G
Sbjct: 1090 VL------RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR--G 1141
Query: 128 PEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIR 187
++V E ++ +VE + ++ +++L +E ++ Q D ++ E+
Sbjct: 1142 AQEV-----GERLQQRHGERDVEVERWRERVAQL------LERWQAVLAQTD-VRQRELE 1189
Query: 188 SV---YHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERE--------LGVQAGHA 236
+ ++E + + + RR E+I+ A RE L H
Sbjct: 1190 QLGRQLRYYRESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1248
Query: 237 QRLQLQKEALDEQLSQVREADRHPGSPRREL-PHAAGAGDASDHSGSPEQQLDEKDARRF 295
++++ + + ++ +++ + + + +L P A+ A SGS + D R
Sbjct: 1249 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1308
Query: 296 QLKIAEL--------SAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRK 347
++ L S +R++E+ L ++R E +R+ E E+ L+K ++L+
Sbjct: 1309 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA----ALEKQRQLAEA 1364
Query: 348 NEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQ 407
+ R +L+ QE + R+ A + + + ++ Q R+ ++Q +
Sbjct: 1365 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1424
Query: 408 QNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESD 467
Q E S+ + E +++R + + + + ++ EEA E+
Sbjct: 1425 QAEAAERSRL--------RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA--EAQ 1474
Query: 468 GSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTL 527
+ +R + D+ + A+ E R + + QRA L+E
Sbjct: 1475 KRQAQEEAERLRRQ--VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1532
Query: 528 DAER-----EVKTREQLQAEVQRAQ----ARIEDLEKALAEQ-GQDMKWIEEKQALYRRN 577
+AER EV+ Q+Q ++ AQ A ++ + AE+ Q + ++E+ +
Sbjct: 1533 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1592
Query: 578 QELVEKIKQMETEEARLRHEVQDARDQ-----NELLEFRILELEERERKSPAISFHHTPF 632
+E E+ Q + E R R E + ++ NE L R+ E ++KS A +
Sbjct: 1593 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1652
Query: 633 VDGKSPLQVYCEAEGVT----DIVVAELMKKLDILGDNA--NLTNEEQVVVIQART---- 682
+ + + +AE ++ EL K+ + A L E++++ ++A T
Sbjct: 1653 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1712
Query: 683 -VLTLAEKWLQQIEETEAALQRKMVDLE-------SEKELFSKQKGYLDEELDYRKQALD 734
L E+ L +++ AA +K +LE +E E+ K +EE ++
Sbjct: 1713 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE----SRSTS 1768
Query: 735 QANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQIL 794
+ +K LE EA + L +EA A L+EE + + ++A E RQ R ++L
Sbjct: 1769 EKSKQRLEAEAGRFRELAEEAARLRA--LAEEAKRQRQLAEEDAARQ-----RAEAERVL 1821
Query: 795 RERMELLQLAQQRIKELE---ERIEAQKRQIKELEEKFLF 831
E++ + A + E E + EA+ +++ L E F
Sbjct: 1822 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1861
Score = 45.8 bits (107), Expect = 2e-04
Identities = 71/344 (20%), Positives = 142/344 (41%), Gaps = 61/344 (17%)
Query: 16 EALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLT-- 73
E L + A ++ + ++I+ QQ ++ RE EL + +E Q + +L
Sbjct: 2401 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL-REAIAELEREKEKLQQEAKLLQLKS 2459
Query: 74 -ELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVK 132
E++T E+ ++E QA++++ L + ++ LL+ + + E +L+ L E K
Sbjct: 2460 EEMQTVQQEQLLQETQALQQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ------DEVAK 2512
Query: 133 TVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHL 192
L E ++ ++ E E+ ++ + E + + + EE +
Sbjct: 2513 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------------------RR 2554
Query: 193 HQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQ--- 249
QEE+ +++++ RR EE+ ++ QRL+ Q + L+EQ
Sbjct: 2555 KQEELQQLEQQ-----RRQQEELLAEEN----------------QRLREQLQLLEEQHRA 2593
Query: 250 -LSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLD----EKDARRFQLKIAELSA 304
L+ E + + LP+ A D PE D + A+R Q +
Sbjct: 2594 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2653
Query: 305 IIRKLEDRNALLSE-ERNELLKRVREAESQYKPLLDK--NKRLS 345
+++L + + E R E ++ + S LL K N++LS
Sbjct: 2654 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLS 2697
Score = 41.2 bits (95), Expect = 0.004
Identities = 71/329 (21%), Positives = 130/329 (39%), Gaps = 40/329 (12%)
Query: 507 MEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKW 566
+ +Q+L+R L++ T + + R+ L + QA + D + A +D
Sbjct: 880 LAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 939
Query: 567 IE-EKQALYRRNQELVEKIKQMETEEARLRH---EVQDARDQNELLEFRI-------LEL 615
E E + Q+L++ ++Q EE+R + E++D R Q E E R L+
Sbjct: 940 AEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 999
Query: 616 EERERKSPAISFHHTPFVD----GKSPLQVYCEAEGVTDI-----VVAELMKKLDILGDN 666
E + I+ + GK ++ EAE V + L +L++
Sbjct: 1000 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1059
Query: 667 ANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEEL 726
+ ++ ++L + Q EE A + ++ + ++ EL
Sbjct: 1060 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL--------PEL 1111
Query: 727 DYRKQALDQANKHILELEAMLYDALQQE--AGAKVAELLSEEEREKLKVAVEQWKRQVMS 784
+ K +L + E + +DAL+ E +V E L + E+ V VE+W
Sbjct: 1112 EATKASLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERW------ 1163
Query: 785 ELRERDAQILRERMELLQLAQQRIKELEE 813
RER AQ+L +L R +ELE+
Sbjct: 1164 --RERVAQLLERWQAVLAQTDVRQRELEQ 1190
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 103 bits (257), Expect = 7e-22
Identities = 181/859 (21%), Positives = 360/859 (41%), Gaps = 102/859 (11%)
Query: 16 EALAALQAANEDLRAKLTDIQIELQ---QEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
EA AA Q E L A+L ++ E++ K++ + R +++ +Q E E + L
Sbjct: 1769 EAAAATQKRQE-LEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1827
Query: 73 TELKT--KLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEK 130
E L EE ++ Q E RQ AE RV+ ++L A+ A R +
Sbjct: 1828 EEAARLRALAEEAKRQRQLAEEDAARQR-AEAERVLA------EKLAAIGEATRLKTEAE 1880
Query: 131 VKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVY 190
+ E ++ E E + ++ + K +EE L + +A + + +
Sbjct: 1881 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1940
Query: 191 HLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQL 250
E+ R +++ E EI L + LE ELG +A+ KE + +
Sbjct: 1941 ----EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1996
Query: 251 SQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLE 310
++ R+ RRE A++ + +++ ++ R + K+ E + + E
Sbjct: 1997 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2056
Query: 311 DRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENI 370
+A + E ++ +AE + + +K ++L L++ ++ L
Sbjct: 2057 QESARQLQLAQEAAQKRLQAEEKAHAF-----AVQQKEQELQQTLQQEQSVLD------- 2104
Query: 371 EMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLER 430
++R A RR + + + Q ERE + Q+ E + L + + ++ E+
Sbjct: 2105 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2164
Query: 431 -----DKLLRFRKQRKKMAKLPKPVV---VETFFGYDEE-----ASLESDGSSVSYQTDR 477
++ R Q ++ A K +E + E+ A +E + +++ Q +
Sbjct: 2165 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2224
Query: 478 TDQTPCTPDDDL--------EEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDA 529
TD D++L E + + E + ++ + L + A ++ + +
Sbjct: 2225 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2284
Query: 530 EREVKTREQLQAEVQRAQARIED---LEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQ 586
+++ T+ LQ E ++ + E+ L A E + + EE A R E + K K
Sbjct: 2285 DKD-NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2343
Query: 587 METEEA-RLRHEVQDARDQNELLEFRILEL-EERERKSPAIS-----FHHTPFVDGKSPL 639
+EA RL+ E + + Q EL + + L E++E+ + ++ F T + + L
Sbjct: 2344 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2403
Query: 640 QVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEA 699
++ EAE + + VAE+ + A EE A+++ +Q EE
Sbjct: 2404 EMSAEAERL-KLRVAEMSR--------AQARAEED------------AQRFRKQAEEIGE 2442
Query: 700 ALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAML---YDALQQEAG 756
L R EL +++K L + L+ ++Q D + + E A L + LQQE
Sbjct: 2443 KLHR--------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE-- 2492
Query: 757 AKVAELLSEE----EREKLKVAVEQWKRQVMSE---LRERDAQILRERMELLQLAQQRIK 809
AK+ +L SEE ++E+L + ++ +SE L +R+ I +E+ +L QL Q +
Sbjct: 2493 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2552
Query: 810 ELEERIEAQKRQIKELEEK 828
+ ++ E Q+RQ +++E++
Sbjct: 2553 KAQQLREEQQRQQQQMEQE 2571
Score = 95.9 bits (237), Expect = 1e-19
Identities = 150/689 (21%), Positives = 284/689 (41%), Gaps = 92/689 (13%)
Query: 9 RAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQ-ELRQVREHEQHK 67
R + E + AL+A+ E A ++++EL + +S R K Q EL R+ +
Sbjct: 1945 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ--- 2001
Query: 68 TAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRV--IKIKDNENQRLQALL----- 120
E + + EE++++ A E RQ +A L V +K K E +RL+
Sbjct: 2002 -LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2060
Query: 121 ---------SALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEA 171
+ R EK + + ++E ++ + E+ + Q E + A+R EEA
Sbjct: 2061 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2120
Query: 172 LTLVIQADKIKAAEIRSVYHLH----------------QEEITRIKKECEREIRRLMEEI 215
+QA++ A R V Q +++KE E+E R +
Sbjct: 2121 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2180
Query: 216 KFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLS----QVREADRHPGSPRRELPHA- 270
+ R + E+ A++ QK ++++L+ Q+ E D EL
Sbjct: 2181 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2240
Query: 271 AGAGDASDHSGSPEQQL-----DEKDARRFQLKI-AELSAIIRKLEDRNALLSEERNELL 324
A A +A+ E++L ++ + + +I AE A+I + +D +E E +
Sbjct: 2241 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2300
Query: 325 KRVREAESQYKPLLDKNKRLSR-KNEDLSHALRRMENKLKF---VTQENIEMRQRAGIIR 380
K+V E ++ + RL + EDL+ E LK QE ++ A +++
Sbjct: 2301 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2360
Query: 381 RPSSLNDLDQSQDEREVDFLKLQIVE-----QQNLIDELSKTLETAGYVKSVLER----- 430
+ L + + + + + Q+ E Q+ L E + LE + + + R
Sbjct: 2361 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2420
Query: 431 -------DKLLRFRKQ---------RKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQ 474
+ RFRKQ R ++A K +V+T +++ +++ +
Sbjct: 2421 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2480
Query: 475 TDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAY-----ALLQ-----EQVG 524
++ + L + ++E ++ QL E QALQ+++ +LLQ EQ
Sbjct: 2481 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2540
Query: 525 GTLDA--EREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMK--WIEEKQALYRRNQEL 580
L+ + EV +QL+ E QR Q ++E + L ++ + E ++ + R+ +EL
Sbjct: 2541 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2600
Query: 581 VEKIKQMETEEARLRHEVQDARDQNELLE 609
+ +Q +E L E Q R+Q +LLE
Sbjct: 2601 QQLEQQRRQQEELLAEENQRLREQLQLLE 2629
Score = 95.5 bits (236), Expect = 2e-19
Identities = 181/811 (22%), Positives = 336/811 (41%), Gaps = 113/811 (13%)
Query: 39 LQQEKSKVSKVEREKNQELRQVRE--HEQHKTAVLLTELKTKLHEEKMKELQAVRETLLR 96
+++E+ + E+ + L +V +Q + A + K + E + Q ++E ++R
Sbjct: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430
Query: 97 QHEAELLRVIKIKDNENQR--LQALLSALRDGGPEKVKT-VLLSEAKEEAKKGFEVE--K 151
+ EA + D + Q+ +Q L LR +++ +EA E ++ E E
Sbjct: 1431 REEAAV-------DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1483
Query: 152 VKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRL 211
V++Q E +E + + E +QA + +A E + QEE R++++ + E +R
Sbjct: 1484 VRLQLEATERQRGGAEGE------LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR- 1536
Query: 212 MEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQVREADRHPGSPRRELPHAA 271
K +A L + +A A+ Q +AL+E Q EA+R + E+ A
Sbjct: 1537 ------KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERAR 1588
Query: 272 GAGDASDHS-GSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREA 330
A + + S E +L K A F K A+L R L++ + +++ R E +R ++
Sbjct: 1589 QVQVALETAQRSAEAELQSKRA-SFAEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQ 1644
Query: 331 ESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQ 390
+ + + L R + ALR + + E+ Q+ + + + +
Sbjct: 1645 AEAERAREEAERELERWQLKANEALR--------LRLQAEEVAQQKSLAQAEAEKQKEEA 1696
Query: 391 SQDEREVDFLKLQIVEQQNLID-ELSKTLETA-GYVKSVLERD-KLLRFRKQRKKMAKLP 447
++ R + Q V Q+ L + EL K + A G + L + +L+R R
Sbjct: 1697 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR---------- 1746
Query: 448 KPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTM 507
ET G + LE + + + + Q ++E E ++
Sbjct: 1747 ----AETEQGEQQRQLLEEELARLQREAAAATQ-------------KRQELEAELAKVRA 1789
Query: 508 EYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLE--KALAEQGQDMK 565
E + L + A +E+ T + K++++L+AE R + E+ +ALAE+ + +
Sbjct: 1790 EMEVLLASKARAEEESRSTSE-----KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1844
Query: 566 WIEEKQALYRR---NQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEE----- 617
+ E+ A +R + L EK+ + E RL+ E + A + E R+ L E
Sbjct: 1845 QLAEEDAARQRAEAERVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1903
Query: 618 RERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKL--DILGDNANLTNEEQV 675
R R + H + + L+ ++E E K L D L + EE++
Sbjct: 1904 RRRLEEQAAQHKADIEERLAQLRKASDSE-------LERQKGLVEDTLRQRRQV--EEEI 1954
Query: 676 VVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQ 735
+ ++A A K E L+ + +E L SK++ L E ++Q +
Sbjct: 1955 LALKASFEKAAAGK-------AELELELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAE 2005
Query: 736 ANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILR 795
+ E E + +L E A + EE E+LK VE+ +R LRER Q
Sbjct: 2006 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR-----LRERAEQESA 2060
Query: 796 ERMELLQLAQQRIKELEERIEAQKRQIKELE 826
+++L Q A Q+ + EE+ A Q KE E
Sbjct: 2061 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2091
Score = 92.4 bits (228), Expect = 2e-18
Identities = 173/835 (20%), Positives = 335/835 (40%), Gaps = 121/835 (14%)
Query: 48 KVEREKNQELRQVREHEQ---HKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLR 104
+ E E+ ++ RQ+ E E + A T+ + +L E ++ +++A E LL
Sbjct: 1746 RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL-EAELAKVRAEMEVLLASKARAEEE 1804
Query: 105 VIKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGA 164
+ QRL+A R+ E + L+E + ++ E + + + E A
Sbjct: 1805 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE------A 1858
Query: 165 KRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECERE-IRRLMEEIKFKDRAVF 223
+R + E L + +A ++K + EI +KE E E +RRL E+ F+ R +
Sbjct: 1859 ERVLAEKLAAIGEATRLKT----------EAEIALKEKEAENERLRRLAEDEAFQRRRLE 1908
Query: 224 ---------VLERELGVQAGHAQRLQLQKEALDEQLSQVREADRH------------PGS 262
+ ER ++ L+ QK +++ L Q R+ + G
Sbjct: 1909 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1968
Query: 263 PRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEER-N 321
EL +A D S EQ E +A R + AE E+R +EER
Sbjct: 1969 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAE--------EERRRREAEERVQ 2018
Query: 322 ELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRR 381
+ L EA Q K L++ +RL K E+ RR+ + + + +++ Q A R
Sbjct: 2019 KSLAAEEEAARQRKAALEEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRL 2074
Query: 382 PSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKL------LR 435
+ + ++E + L+ + ++Q+++D+L E A E ++ +
Sbjct: 2075 QAEEKAHAFAVQQKEQE-LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2133
Query: 436 FRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAK 495
R+Q ++ +L + + +A+ E + R Q + A+
Sbjct: 2134 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2193
Query: 496 EETELRFRQLTMEYQA-LQRAYALLQEQVGGT---------------LDAEREVKTREQL 539
E +F + T+ +A +++ L+ Q+ T +A + R Q+
Sbjct: 2194 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2253
Query: 540 QAEVQRAQARIEDLEKALA--EQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHE 597
+ E+ + ++E+L K A E + +K R QE EK+KQ+ E ARL
Sbjct: 2254 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2313
Query: 598 VQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELM 657
Q+A +L E + + K K +Q EA L
Sbjct: 2314 AQEAARLRQLAEEDLAQQRALAEKML------------KEKMQAVQEA--------TRLK 2353
Query: 658 KKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSK 717
+ ++L L E QAR + E+ QQ+ E QR + + E +++L
Sbjct: 2354 AEAELLQQQKELAQE------QARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQLEMS 2406
Query: 718 QKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKV--AELLSEEEREKLKVAV 775
+ E L R + +A E +A + +E G K+ EL ++E KV +
Sbjct: 2407 AEA---ERLKLRVAEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQE-----KVTL 2457
Query: 776 EQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEKFL 830
Q ++ + + DA+ LRE + L+ ++++++ + ++ + +++ ++++ L
Sbjct: 2458 VQ-TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2511
Score = 83.6 bits (205), Expect = 7e-16
Identities = 184/880 (20%), Positives = 364/880 (41%), Gaps = 107/880 (12%)
Query: 10 AKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTA 69
A+ +K AL A LR++L +L+Q +S +S + EK + + V Q
Sbjct: 1072 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS-LSAIYLEKLKTISLVIRGTQGAEE 1130
Query: 70 VLLTELKTKLHEEKMKELQAVRETL--LRQHEAELLRVIKIKDNENQRLQALLSALRDGG 127
VL + HEE++KE QAV TL L +A L ++ + + AL LR G
Sbjct: 1131 VL------RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR--G 1182
Query: 128 PEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIR 187
++V E ++ +VE + ++ +++L +E ++ Q D ++ E+
Sbjct: 1183 AQEV-----GERLQQRHGERDVEVERWRERVAQL------LERWQAVLAQTD-VRQRELE 1230
Query: 188 SV---YHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERE--------LGVQAGHA 236
+ ++E + + + RR E+I+ A RE L H
Sbjct: 1231 QLGRQLRYYRESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1289
Query: 237 QRLQLQKEALDEQLSQVREADRHPGSPRREL-PHAAGAGDASDHSGSPEQQLDEKDARRF 295
++++ + + ++ +++ + + + +L P A+ A SGS + D R
Sbjct: 1290 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1349
Query: 296 QLKIAEL--------SAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRK 347
++ L S +R++E+ L ++R E +R+ E E+ L+K ++L+
Sbjct: 1350 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA----ALEKQRQLAEA 1405
Query: 348 NEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQ 407
+ R +L+ QE + R+ A + + + ++ Q R+ ++Q +
Sbjct: 1406 HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1465
Query: 408 QNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESD 467
Q E S+ + E +++R + + + + ++ EEA E+
Sbjct: 1466 QAEAAERSRL--------RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA--EAQ 1515
Query: 468 GSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTL 527
+ +R + D+ + A+ E R + + QRA L+E
Sbjct: 1516 KRQAQEEAERLRRQ--VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1573
Query: 528 DAER-----EVKTREQLQAEVQRAQ----ARIEDLEKALAEQ-GQDMKWIEEKQALYRRN 577
+AER EV+ Q+Q ++ AQ A ++ + AE+ Q + ++E+ +
Sbjct: 1574 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1633
Query: 578 QELVEKIKQMETEEARLRHEVQDARDQ-----NELLEFRILELEERERKSPAISFHHTPF 632
+E E+ Q + E R R E + ++ NE L R+ E ++KS A +
Sbjct: 1634 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1693
Query: 633 VDGKSPLQVYCEAEGVT----DIVVAELMKKLDILGDNA--NLTNEEQVVVIQART---- 682
+ + + +AE ++ EL K+ + A L E++++ ++A T
Sbjct: 1694 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1753
Query: 683 -VLTLAEKWLQQIEETEAALQRKMVDLE-------SEKELFSKQKGYLDEELDYRKQALD 734
L E+ L +++ AA +K +LE +E E+ K +EE ++
Sbjct: 1754 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE----SRSTS 1809
Query: 735 QANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQIL 794
+ +K LE EA + L +EA A L+EE + + ++A E RQ R ++L
Sbjct: 1810 EKSKQRLEAEAGRFRELAEEAARLRA--LAEEAKRQRQLAEEDAARQ-----RAEAERVL 1862
Query: 795 RERMELLQLAQQRIKELE---ERIEAQKRQIKELEEKFLF 831
E++ + A + E E + EA+ +++ L E F
Sbjct: 1863 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1902
Score = 45.8 bits (107), Expect = 2e-04
Identities = 71/344 (20%), Positives = 142/344 (41%), Gaps = 61/344 (17%)
Query: 16 EALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLT-- 73
E L + A ++ + ++I+ QQ ++ RE EL + +E Q + +L
Sbjct: 2442 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL-REAIAELEREKEKLQQEAKLLQLKS 2500
Query: 74 -ELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVK 132
E++T E+ ++E QA++++ L + ++ LL+ + + E +L+ L E K
Sbjct: 2501 EEMQTVQQEQLLQETQALQQSFLSEKDS-LLQRERFIEQEKAKLEQLFQ------DEVAK 2553
Query: 133 TVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHL 192
L E ++ ++ E E+ ++ + E + + + EE +
Sbjct: 2554 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------------------RR 2595
Query: 193 HQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQLQKEALDEQ--- 249
QEE+ +++++ RR EE+ ++ QRL+ Q + L+EQ
Sbjct: 2596 KQEELQQLEQQ-----RRQQEELLAEEN----------------QRLREQLQLLEEQHRA 2634
Query: 250 -LSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLD----EKDARRFQLKIAELSA 304
L+ E + + LP+ A D PE D + A+R Q +
Sbjct: 2635 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2694
Query: 305 IIRKLEDRNALLSE-ERNELLKRVREAESQYKPLLDK--NKRLS 345
+++L + + E R E ++ + S LL K N++LS
Sbjct: 2695 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLS 2738
Score = 41.2 bits (95), Expect = 0.004
Identities = 71/329 (21%), Positives = 130/329 (39%), Gaps = 40/329 (12%)
Query: 507 MEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKW 566
+ +Q+L+R L++ T + + R+ L + QA + D + A +D
Sbjct: 921 LAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 980
Query: 567 IE-EKQALYRRNQELVEKIKQMETEEARLRH---EVQDARDQNELLEFRI-------LEL 615
E E + Q+L++ ++Q EE+R + E++D R Q E E R L+
Sbjct: 981 AEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1040
Query: 616 EERERKSPAISFHHTPFVD----GKSPLQVYCEAEGVTDI-----VVAELMKKLDILGDN 666
E + I+ + GK ++ EAE V + L +L++
Sbjct: 1041 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1100
Query: 667 ANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEEL 726
+ ++ ++L + Q EE A + ++ + ++ EL
Sbjct: 1101 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL--------PEL 1152
Query: 727 DYRKQALDQANKHILELEAMLYDALQQE--AGAKVAELLSEEEREKLKVAVEQWKRQVMS 784
+ K +L + E + +DAL+ E +V E L + E+ V VE+W
Sbjct: 1153 EATKASLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERW------ 1204
Query: 785 ELRERDAQILRERMELLQLAQQRIKELEE 813
RER AQ+L +L R +ELE+
Sbjct: 1205 --RERVAQLLERWQAVLAQTDVRQRELEQ 1231
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 102 bits (253), Expect = 2e-21
Identities = 187/908 (20%), Positives = 375/908 (41%), Gaps = 138/908 (15%)
Query: 13 DKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
D + +A LQA ++L+ +L + ELQ ++ KN L+ VRE + +
Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQ-----I 1120
Query: 73 TELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVK 132
EL+ EK +A ++ ++ +E L +K + + A LR ++V
Sbjct: 1121 AELQEDFESEKASRNKAEKQ---KRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA 1177
Query: 133 TVLLSEAKEEAKKGFEVEKVKM-QQEISELKGAKRQVEEALTLVIQADKIK--------- 182
L +A EE K E + M Q+ + L+ Q+E+A +K K
Sbjct: 1178 E--LKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235
Query: 183 -AAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRLQL 241
A E++ + + E + +K+ + +++ L ++ DR L EL +A +L
Sbjct: 1236 LACEVKVLQQVKAESEHK-RKKLDAQVQELHAKVSEGDR----LRVELAEKAS-----KL 1285
Query: 242 QKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAE 301
Q E LD + + EA+ ++ + A A ++ L E+ ++
Sbjct: 1286 QNE-LDNVSTLLEEAE------KKGIKFAKDAASLESQLQDTQELLQEETRQKL-----N 1333
Query: 302 LSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENK 361
LS+ IR+LE+ L E++ E + + E Q L + +K +D + +E
Sbjct: 1334 LSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEA 1393
Query: 362 LKFVTQENIEMRQRAGIIRRPSSLNDLDQSQD--EREVDFLKLQIVEQQNLIDELSKTLE 419
K + ++ + QR + + + + L+++++ ++E+D L + + Q+ + L K +
Sbjct: 1394 KKKLLKDAEALSQR--LEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQK 1451
Query: 420 TAGYV----KSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQT 475
+ KS+ R R R + + K K + + EA E + + +
Sbjct: 1452 KFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRA 1511
Query: 476 DRTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDA------ 529
D D + DD+ G E E R L + + ++ L++++ T DA
Sbjct: 1512 DMEDL--MSSKDDV--GKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567
Query: 530 ---------EREVKTREQ--------LQAEVQRAQARIED--LEKALAEQGQ-----DMK 565
ER+++TR++ L +V+ +A +ED ++ALA + D+K
Sbjct: 1568 NMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLK 1627
Query: 566 WIEEK-QALYRRNQELVEKIKQMETEEARLRHEVQDARDQNE--------------LLEF 610
+E + +A + E+++++++++ + + E+++AR + LE
Sbjct: 1628 DLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEA 1687
Query: 611 RILELEER-----------ERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKK 659
IL+L+E E++ ++ T GKS L + + + +A+L ++
Sbjct: 1688 EILQLQEELASSERARRHAEQERDELADEITNSASGKSAL---LDEKRRLEARIAQLEEE 1744
Query: 660 LDILGDNANLTNEE------QVVVIQA-----RTVLTLAEKWLQQIEETEAALQRKMVDL 708
L+ N L N+ QV + A R+ ++ QQ+E L+ K+ +L
Sbjct: 1745 LEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQEL 1804
Query: 709 ESEKE--------LFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVA 760
E + + G L+E+L+ + ANK + E L + Q +
Sbjct: 1805 EGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRH 1864
Query: 761 ELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKR 820
+E+ EK ++Q KRQ + E E + R +L Q+ + + E E R
Sbjct: 1865 ADQYKEQMEKANARMKQLKRQ-LEEAEEEATRANASRRKL----QRELDDATEANEGLSR 1919
Query: 821 QIKELEEK 828
++ L+ +
Sbjct: 1920 EVSTLKNR 1927
Score = 96.7 bits (239), Expect = 8e-20
Identities = 197/905 (21%), Positives = 377/905 (41%), Gaps = 139/905 (15%)
Query: 14 KAEALAALQAANEDLRAKLTDIQIELQQEKSKV----SKVEREKNQELRQ---VREHEQH 66
K + L + E+L+AK ++ ++++++++KV ++ER+ Q L + + E Q
Sbjct: 840 KVKPLLQVTRQEEELQAKDEEL-LKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA 898
Query: 67 KTAVL--LTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALR 124
+T + E++ +L +K +EL+ + L + E E R +I NE +++QA + L
Sbjct: 899 ETELFAEAEEMRARLAAKK-QELEEILHDLESRVEEEEER-NQILQNEKKKMQAHIQDLE 956
Query: 125 DGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKI--- 181
+ E +E A++ ++EKV + +I +++ +E+ + I+ K+
Sbjct: 957 EQLDE----------EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMED 1006
Query: 182 KAAEIRSVYHLHQEE---ITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQR 238
+ AE S +E+ + +I+ + E I L E +K +++ LE+ G
Sbjct: 1007 RIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTD 1066
Query: 239 LQLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLK 298
LQ + + E +Q+ E EL A GD D + L K R Q +
Sbjct: 1067 LQ---DQIAELQAQIDELKLQLAKKEEELQGALARGD--DETLHKNNAL--KVVRELQAQ 1119
Query: 299 IAEL-------SAIIRKLEDRNALLSEERNEL------------------LKRVREAESQ 333
IAEL A K E + LSEE L KR +E
Sbjct: 1120 IAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAEL 1179
Query: 334 YKPLLDKNKR---------------LSRKNEDLSHALR---RMENKLKFVTQENIEMRQR 375
K L ++ K L +E L A R +E + + +N E+
Sbjct: 1180 KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE 1239
Query: 376 AGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKLLR 435
++++ + ++ + + + +V L ++ E L EL+ E A +++ L+ L
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELA---EKASKLQNELDNVSTL- 1295
Query: 436 FRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAK 495
+ KK K K D + L+ + + R Q + L+E +
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLE-EEKNSLQE--QQ 1352
Query: 496 EETELRFRQLTMEYQALQRAYALLQEQVG---GTLDAEREVKTR---------------- 536
EE E + L + ALQ A +++V GT+++ E K +
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKA 1412
Query: 537 ---EQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEAR 593
++L+ R Q ++DL L Q Q +E+KQ +K Q+ EE
Sbjct: 1413 LAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQ----------KKFDQLLAEEKS 1462
Query: 594 LRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVV 653
+ + RD+ E E RE+++ A+S + + + +
Sbjct: 1463 ISARYAEERDR--------AEAEAREKETKALSLARA-LEEALEAKEEFERQNKQLRADM 1513
Query: 654 AELMKKLDILGDNAN-LTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEK 712
+LM D +G N + L ++ + Q + T E+ +++ TE A R V++++ K
Sbjct: 1514 EDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK 1573
Query: 713 ELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLK 772
F + DE+ + +K+ L K + ELEA L D +Q A A ++ E + + L+
Sbjct: 1574 AQFERDLQTRDEQNEEKKRLL---IKQVRELEAELEDERKQRALAVASKKKMEIDLKDLE 1630
Query: 773 VAVE---QWKRQVMSELRERDAQILRERMELLQLAQQR------IKELEERIEAQKRQIK 823
+E + + +V+ +LR+ AQ+ + EL + R KE E+++++ + +I
Sbjct: 1631 AQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEIL 1690
Query: 824 ELEEK 828
+L+E+
Sbjct: 1691 QLQEE 1695
Score = 78.6 bits (192), Expect = 2e-14
Identities = 120/572 (20%), Positives = 238/572 (41%), Gaps = 40/572 (6%)
Query: 13 DKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLL 72
+KA A L+ L+ +L D+ ++L ++ S +E+ K ++ Q+ E+ +A
Sbjct: 1410 EKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEK-KQKKFDQLLAEEKSISARYA 1468
Query: 73 TELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLSALRDGGPEKVK 132
E E + KE +A+ +L R E E L + + +N++L+A + L + K
Sbjct: 1469 EERDRAEAEAREKETKAL--SLARALE-EALEAKEEFERQNKQLRADMEDLMSSKDDVGK 1525
Query: 133 TVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEA-LTLVIQADKIKAAEIRSVYH 191
V E++K+ E + +M+ ++ EL+ + E+A L L + +KA R +
Sbjct: 1526 NV---HELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL-Q 1581
Query: 192 LHQEEITRIKKECEREIRRLMEEIKF--KDRAVFVLER---ELGVQAGHAQRLQLQKEAL 246
E+ K+ +++R L E++ K RA+ V + E+ ++ AQ ++ +A
Sbjct: 1582 TRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQ-IEAANKAR 1640
Query: 247 DEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKIAELSAII 306
DE + Q+R+ +REL A + D + + EK + + +I +L +
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEI----FAQSKESEKKLKSLEAEILQLQEEL 1696
Query: 307 RKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRK----NEDLSHALRRME--- 359
E +ER+EL + + S LLD+ +RL + E+L ME
Sbjct: 1697 ASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLN 1756
Query: 360 NKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLE 419
++ + T + + R + +D + Q ER+ LK ++ E + + K
Sbjct: 1757 DRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATI 1816
Query: 420 TA-----GYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGY-DEEASLESDGSSVSY 473
+A G ++ LE++ + R K+ + + + E F DE + +
Sbjct: 1817 SALEAKIGQLEEQLEQE--AKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEK 1874
Query: 474 QTDRTDQTPCTPDDDLEE----GMAKEETELRFRQLTMEYQALQRAYALLQEQV--GGTL 527
R Q ++ EE ++ + + T + L R + L+ ++ GG +
Sbjct: 1875 ANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPI 1934
Query: 528 DAEREVKTREQLQAEVQRAQARIEDLEKALAE 559
R QL E + +D E ++
Sbjct: 1935 SFSSSRSGRRQLHLEGASLELSDDDTESKTSD 1966
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.337
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,242,761
Number of Sequences: 37866
Number of extensions: 1240625
Number of successful extensions: 18498
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 308
Number of HSP's successfully gapped in prelim test: 1072
Number of HSP's that attempted gapping in prelim test: 7729
Number of HSP's gapped (non-prelim): 6642
length of query: 844
length of database: 18,247,518
effective HSP length: 111
effective length of query: 733
effective length of database: 14,044,392
effective search space: 10294539336
effective search space used: 10294539336
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.