Search of human proteins with 157419154

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157419154 selectin P precursor [Homo sapiens]
         (830 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157419154 selectin P precursor [Homo sapiens]                     1803   0.0  
gi|187960042 selectin E precursor [Homo sapiens]                      533   e-151
gi|4506875 selectin L precursor [Homo sapiens]                        359   7e-99
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap...   258   1e-68
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap...   258   1e-68
gi|148886654 polydom [Homo sapiens]                                   255   1e-67
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]          251   1e-66
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa...   242   1e-63
gi|54792123 complement component (3d/Epstein Barr virus) recepto...   218   1e-56
gi|42544177 complement component (3d/Epstein Barr virus) recepto...   216   5e-56
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]           215   1e-55
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi...   192   1e-48
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi...   192   1e-48
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ...   162   9e-40
gi|4502503 complement component 4 binding protein, alpha chain p...   137   4e-32
gi|62739186 complement factor H isoform a precursor [Homo sapiens]    128   2e-29
gi|110611237 coagulation factor XIII B subunit precursor [Homo s...   118   3e-26
gi|153266841 apolipoprotein H precursor [Homo sapiens]                117   6e-26
gi|62739188 complement factor H isoform b precursor [Homo sapiens]    103   5e-22
gi|5454086 sushi-repeat-containing protein, X-linked [Homo sapiens]   100   4e-21
gi|7657619 sushi-repeat-containing protein, X-linked 2 [Homo sap...    93   9e-19
gi|38045915 pregnancy-associated plasma protein A preproprotein ...    93   1e-18
gi|27502411 CD46 antigen, complement regulatory protein isoform ...    91   3e-18
gi|27502409 CD46 antigen, complement regulatory protein isoform ...    91   3e-18
gi|27502405 CD46 antigen, complement regulatory protein isoform ...    91   3e-18
gi|27502427 CD46 antigen, complement regulatory protein isoform ...    91   4e-18
gi|166235138 seizure related 6 homolog (mouse)-like 2 isoform 3 ...    90   7e-18
gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2 ...    90   7e-18
gi|27502421 CD46 antigen, complement regulatory protein isoform ...    90   1e-17
gi|27502417 CD46 antigen, complement regulatory protein isoform ...    90   1e-17

>gi|157419154 selectin P precursor [Homo sapiens]
          Length = 830

 Score = 1803 bits (4669), Expect = 0.0
 Identities = 830/830 (100%), Positives = 830/830 (100%)

Query: 1   MANCQIAILYQRFQRVVFGISQLLCFSALISELTNQKEVAAWTYHYSTKAYSWNISRKYC 60
           MANCQIAILYQRFQRVVFGISQLLCFSALISELTNQKEVAAWTYHYSTKAYSWNISRKYC
Sbjct: 1   MANCQIAILYQRFQRVVFGISQLLCFSALISELTNQKEVAAWTYHYSTKAYSWNISRKYC 60

Query: 61  QNRYTDLVAIQNKNEIDYLNKVLPYYSSYYWIGIRKNNKTWTWVGTKKALTNEAENWADN 120
           QNRYTDLVAIQNKNEIDYLNKVLPYYSSYYWIGIRKNNKTWTWVGTKKALTNEAENWADN
Sbjct: 61  QNRYTDLVAIQNKNEIDYLNKVLPYYSSYYWIGIRKNNKTWTWVGTKKALTNEAENWADN 120

Query: 121 EPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHALCYTASCQDMSCSKQGECLETIGN 180
           EPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHALCYTASCQDMSCSKQGECLETIGN
Sbjct: 121 EPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHALCYTASCQDMSCSKQGECLETIGN 180

Query: 181 YTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPS 240
           YTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPS
Sbjct: 181 YTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPS 240

Query: 241 KLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVG 300
           KLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVG
Sbjct: 241 KLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVG 300

Query: 301 PEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRV 360
           PEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRV
Sbjct: 301 PEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRV 360

Query: 361 RGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGF 420
           RGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGF
Sbjct: 361 RGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGF 420

Query: 421 MLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNE 480
           MLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNE
Sbjct: 421 MLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNE 480

Query: 481 GLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFIC 540
           GLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFIC
Sbjct: 481 GLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFIC 540

Query: 541 DEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHF 600
           DEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHF
Sbjct: 541 DEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHF 600

Query: 601 SCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPG 660
           SCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPG
Sbjct: 601 SCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPG 660

Query: 661 TFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNL 720
           TFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNL
Sbjct: 661 TFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNL 720

Query: 721 WGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEALTYFGGAVA 780
           WGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEALTYFGGAVA
Sbjct: 721 WGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEALTYFGGAVA 780

Query: 781 STIGLIMGGTLLALLRKRFRQKDDGKCPLNPHSHLGTYGVFTNAAFDPSP 830
           STIGLIMGGTLLALLRKRFRQKDDGKCPLNPHSHLGTYGVFTNAAFDPSP
Sbjct: 781 STIGLIMGGTLLALLRKRFRQKDDGKCPLNPHSHLGTYGVFTNAAFDPSP 830


>gi|187960042 selectin E precursor [Homo sapiens]
          Length = 610

 Score =  533 bits (1374), Expect = e-151
 Identities = 240/536 (44%), Positives = 329/536 (61%), Gaps = 6/536 (1%)

Query: 37  KEVAAWTYHYSTKAYSWNISRKYCQNRYTDLVAIQNKNEIDYLNKVLPYYSSYYWIGIRK 96
           KE  AW+Y+ ST+A +++ +  YCQ RYT LVAIQNK EI+YLN +L Y  SYYWIGIRK
Sbjct: 17  KESGAWSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLNSILSYSPSYYWIGIRK 76

Query: 97  NNKTWTWVGTKKALTNEAENWADNEPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHA 156
            N  W WVGT+K LT EA+NWA  EPNN++ +EDCVEIYIK     G WNDE C KKK A
Sbjct: 77  VNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLA 136

Query: 157 LCYTASCQDMSCSKQGECLETIGNYTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHP 216
           LCYTA+C + SCS  GEC+ETI NYTC C PGF G +CE +  C  LE P+H  + CSHP
Sbjct: 137 LCYTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHP 196

Query: 217 LGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCL 276
           LGNFS+NS CS  C  GY  +    ++C++SG W+   P C   +C  +  P  G + C 
Sbjct: 197 LGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECF 256

Query: 277 HSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMD 336
            +  +F   ++C+F CEEGF L+G + +QCT+SG W    P CKAV C+ +  P  G++ 
Sbjct: 257 QNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVR 316

Query: 337 CVH-PLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHG 395
           C H P   F + SSC F C+ G+ ++G   + C   G W+  +P CEA  C  L +P  G
Sbjct: 317 CSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERG 376

Query: 396 SMDCSPSLR-AFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVP 454
            M+C PS   +F+Y ++C F C +GF+L+G+  ++C   G+W    P C+A++C  +  P
Sbjct: 377 YMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQP 436

Query: 455 NEARVNCSH-PFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPL 513
            +  V C+H P G F Y+S C+F+C EG  L G++ L+C + G W    P CQ + C+ L
Sbjct: 437 PKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSL 496

Query: 514 LSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEA 569
             P    M+C    G   + + C+F C EG++L+G     C  +G W+   P CEA
Sbjct: 497 AVPGKINMSC---SGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEA 549



 Score =  345 bits (884), Expect = 1e-94
 Identities = 174/487 (35%), Positives = 257/487 (52%), Gaps = 42/487 (8%)

Query: 318 VCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAP 377
           +C    C +      G  +CV  +  +    +CK  C PG+       L+C         
Sbjct: 137 LCYTAACTNTSCSGHG--ECVETINNY----TCK--CDPGF-----SGLKCE-------- 175

Query: 378 LPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWT 437
               + ++C  LESP HGS+ CS  L  F Y+++CS  C  G++    + ++C + G+W+
Sbjct: 176 ----QIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWS 231

Query: 438 APAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGN 497
           AP P C  ++C  +  P    V C    G+F + + C+F C EG  L+GA  LQC ++GN
Sbjct: 232 APIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN 291

Query: 498 WNSVPPECQAIPCTPLLSPQNGTMTCVQ-PLGSSSYKSTCQFICDEGYSLSGPERLDCTR 556
           W++  P C+A+ C  +  PQNG++ C   P G  ++KS+C F C+EG+ L GP +++CT 
Sbjct: 292 WDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTT 351

Query: 557 SGRWTDSPPMCEAIKCPELFAPEQGSLDC-SDTRGEFNVGSTCHFSCDNGFKLEGPNNVE 615
            G+WT   P+CEA +C  L  PE+G ++C     G F  GS+C FSC+ GF L+G   ++
Sbjct: 352 QGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQ 411

Query: 616 CTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHP-GTFGFNTTCYFGCNA 674
           C  +G W    PTC+         V+C A+  P +G + C H P G F + ++C F C  
Sbjct: 412 CGPTGEWDNEKPTCEA--------VRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEE 463

Query: 675 GFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHC 734
           GF L G + L C   GQWT   P+C+ VKCS L V   I M+CS   G   +G++C F C
Sbjct: 464 GFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCS---GEPVFGTVCKFAC 520

Query: 735 LEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEALTYFGGAVASTIGLIMGGTLLAL 794
            EG  LNGSA   C   GHWS  +PTC+A     +  +    G  A+ + L+     L  
Sbjct: 521 PEGWTLNGSAARTCGATGHWSGLLPTCEA---PTESNIPLVAGLSAAGLSLLTLAPFLLW 577

Query: 795 LRKRFRQ 801
           LRK  R+
Sbjct: 578 LRKCLRK 584


>gi|4506875 selectin L precursor [Homo sapiens]
          Length = 372

 Score =  359 bits (921), Expect = 7e-99
 Identities = 159/310 (51%), Positives = 206/310 (66%)

Query: 11  QRFQRVVFGISQLLCFSALISELTNQKEVAAWTYHYSTKAYSWNISRKYCQNRYTDLVAI 70
           Q  QR ++ I +L  ++ L  +         WTYHYS K  +W  +R++C++ YTDLVAI
Sbjct: 8   QSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAI 67

Query: 71  QNKNEIDYLNKVLPYYSSYYWIGIRKNNKTWTWVGTKKALTNEAENWADNEPNNKRNNED 130
           QNK EI+YL K LP+  SYYWIGIRK    WTWVGT K+LT EAENW D EPNNK+N ED
Sbjct: 68  QNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKED 127

Query: 131 CVEIYIKSPSAPGKWNDEHCLKKKHALCYTASCQDMSCSKQGECLETIGNYTCSCYPGFY 190
           CVEIYIK     GKWND+ C K K ALCYTASCQ  SCS  GEC+E I NYTC+C  G+Y
Sbjct: 128 CVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYY 187

Query: 191 GPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIW 250
           GP+C++V +C  LE P+   M+C+HPLGNFSF+SQC+F C++G  + G  +  C   G W
Sbjct: 188 GPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNW 247

Query: 251 TNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASG 310
           ++  P C   QC PL  P+ G M C H   +F   S+C+F C EG  L+G +   C +SG
Sbjct: 248 SSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSG 307

Query: 311 VWTAPAPVCK 320
           +W+ P+P+C+
Sbjct: 308 IWSNPSPICQ 317



 Score =  131 bits (330), Expect = 2e-30
 Identities = 58/131 (44%), Positives = 81/131 (61%), Gaps = 1/131 (0%)

Query: 317 PVCK-AVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWS 375
           P C+  +QC+ LEAP  GTMDC HPL  F++ S C F C  G  + G++   C   G+WS
Sbjct: 189 PQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWS 248

Query: 376 APLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ 435
           +P PTC+ I CEPL +P  G M+CS  L +F + + C+F C+EG  L G     C++ G 
Sbjct: 249 SPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGI 308

Query: 436 WTAPAPVCQAL 446
           W+ P+P+CQ L
Sbjct: 309 WSNPSPICQKL 319



 Score =  128 bits (322), Expect = 2e-29
 Identities = 66/178 (37%), Positives = 98/178 (55%), Gaps = 8/178 (4%)

Query: 336 DCVHPL-TAFAYGSSCK-FECQP-GYRVRGLDMLRC-IDSGHWSAPLPTCE-AISCEPLE 390
           D  H L  A  Y +SC+ + C   G  V  ++   C  D G++    P C+  I CEPLE
Sbjct: 145 DACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYG---PQCQFVIQCEPLE 201

Query: 391 SPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQD 450
           +P  G+MDC+  L  F + + C+F C+EG  L G +   C   G W++P P CQ +QC+ 
Sbjct: 202 APELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEP 261

Query: 451 LPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAI 508
           L  P+   +NCSHP  +F + S C+F C+EG  L+G     C ++G W++  P CQ +
Sbjct: 262 LSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKL 319



 Score =  126 bits (316), Expect = 9e-29
 Identities = 72/221 (32%), Positives = 99/221 (44%), Gaps = 27/221 (12%)

Query: 351 KFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDT 410
           K +C   Y  R  D  +  D          C   SC+P     HG  +C   +    Y  
Sbjct: 125 KEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHG--ECVEIIN--NYTC 180

Query: 411 NCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQ-ALQCQDLPVPNEARVNCSHPFGAFR 469
           NC                   ++G +    P CQ  +QC+ L  P    ++C+HP G F 
Sbjct: 181 NC-------------------DVGYY---GPQCQFVIQCEPLEAPELGTMDCTHPLGNFS 218

Query: 470 YQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGS 529
           + S C+F+C+EG  L G     C   GNW+S  P CQ I C PL +P  G M C  PL S
Sbjct: 219 FSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLAS 278

Query: 530 SSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAI 570
            S+ S C FIC EG  L G ++  C  SG W++  P+C+ +
Sbjct: 279 FSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKL 319



 Score =  114 bits (285), Expect = 4e-25
 Identities = 53/129 (41%), Positives = 70/129 (54%), Gaps = 1/129 (0%)

Query: 503 PECQ-AIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWT 561
           P+CQ  I C PL +P+ GTM C  PLG+ S+ S C F C EG +L+G E   C   G W+
Sbjct: 189 PQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWS 248

Query: 562 DSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGR 621
              P C+ I+C  L AP+ G ++CS     F+  S C F C  G +L G     C +SG 
Sbjct: 249 SPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGI 308

Query: 622 WSATPPTCK 630
           WS   P C+
Sbjct: 309 WSNPSPICQ 317



 Score =  106 bits (265), Expect = 8e-23
 Identities = 63/206 (30%), Positives = 88/206 (42%), Gaps = 27/206 (13%)

Query: 557 SGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVEC 616
           +G+W D    C  +K    +        CS            H  C     +E  NN  C
Sbjct: 139 AGKWNDDA--CHKLKAALCYTASCQPWSCSG-----------HGEC-----VEIINNYTC 180

Query: 617 TTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGF 676
                +    P C+ +       +QC  L  P  GTM C H  G F F++ C F C+ G 
Sbjct: 181 NCDVGYYG--PQCQFV-------IQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGT 231

Query: 677 TLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLE 736
            L G    +C P G W++  P C+ ++C  L       MNCS+   +FS+ S C+F C E
Sbjct: 232 NLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSE 291

Query: 737 GQLLNGSAQTACQENGHWSTTVPTCQ 762
           G  L G  +T C+ +G WS   P CQ
Sbjct: 292 GTELIGKKKTICESSGIWSNPSPICQ 317


>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
          Length = 3667

 Score =  258 bits (660), Expect = 1e-68
 Identities = 163/561 (29%), Positives = 248/561 (44%), Gaps = 46/561 (8%)

Query: 210  LMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWT--NKPPQCLAAQCPPLKI 267
            ++N SH    + + ++  F C  GY   GP+ +ECL +G W+  N+ P C    C  L  
Sbjct: 2669 IVNGSH----YEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPT 2724

Query: 268  PERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHL 327
            P  GN     ++    + S+  F+C+ GF LVG  V +C +SG+W+     C A  C   
Sbjct: 2725 PPNGNKIGTQTS----YGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIP 2780

Query: 328  EAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCE 387
            E    G +   +    + Y  +  ++C PG+R+ G  +  C    +WS  LP+C  +SC 
Sbjct: 2781 ELIVNGQVIGEN----YGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCG 2836

Query: 388  PLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQ 447
               SP++G      S   F ++   +F C  G++++G    +C    QW+ P P+C+ + 
Sbjct: 2837 HPGSPIYG----RTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVN 2892

Query: 448  CQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQA 507
            C D  +P  ++       G F Y +V  + CN G  L G+SVL C   G W+   PEC  
Sbjct: 2893 CSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIM 2952

Query: 508  IPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMC 567
            I C     P N  ++  +     ++ ST  + C    SL G     C  +G W+ S P C
Sbjct: 2953 IDCGHPGVPPNAVLSGEK----YTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHC 3008

Query: 568  EAI---KCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSA 624
                   C +   P  GS   S+    F   ST  ++CD G+ L G     C  +G W+ 
Sbjct: 3009 SGDATGTCGDPGTPGHGSRQESN----FRTKSTVRYACDTGYILHGSEERTCLANGSWTG 3064

Query: 625  TPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTL 684
              P CK         VQC    T   G ++     GT  F+++  + C  G+ L G S  
Sbjct: 3065 RQPECK--------AVQCGNPGTTANGKVF--RIDGT-TFSSSVIYSCMEGYILSGPSVR 3113

Query: 685  SCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQL--LNG 742
             C  +G W+   P C  + C +      I  N      ++  G   S+ C  G    LNG
Sbjct: 3114 QCTANGTWSGTLPNCTIISCGD----PGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNG 3169

Query: 743  SAQTACQENGHWSTTVPTCQA 763
            S    C  NG WS  +PTC+A
Sbjct: 3170 SRIRTCTINGTWSGVMPTCRA 3190



 Score =  242 bits (617), Expect = 1e-63
 Identities = 164/579 (28%), Positives = 241/579 (41%), Gaps = 59/579 (10%)

Query: 204  ELPQHVLMNCSHP--------LGN-FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKP 254
            +LP  V ++C HP         GN F+FN   +F C  GY + GP+K +C A+  W++ P
Sbjct: 2826 QLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPP 2885

Query: 255  PQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTA 314
            P C    C    IP             F + +   + C  G+ L G  V+ C  +G W  
Sbjct: 2886 PMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDK 2945

Query: 315  PAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHW 374
            P P C  + C H   P    +        + +GS+  + C     + G     C  +GHW
Sbjct: 2946 PLPECIMIDCGHPGVPPNAVLSG----EKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHW 3001

Query: 375  SAPLPTCEAIS---CEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCD 431
            S   P C   +   C    +P HGS   S     F+  +   + C  G++L G++   C 
Sbjct: 3002 SGSQPHCSGDATGTCGDPGTPGHGSRQESN----FRTKSTVRYACDTGYILHGSEERTCL 3057

Query: 432  NLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQ 491
              G WT   P C+A+QC +       +V          + S   ++C EG +L G SV Q
Sbjct: 3058 ANGSWTGRQPECKAVQCGNPGTTANGKV---FRIDGTTFSSSVIYSCMEGYILSGPSVRQ 3114

Query: 492  CLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYS--LSGP 549
            C A G W+   P C  I C     P NG    ++            ++C  GY+  L+G 
Sbjct: 3115 CTANGTWSGTLPNCTIISCGDPGIPANG----LRYGDDYVVGQNVSYMCQPGYTMELNGS 3170

Query: 550  ERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLE 609
                CT +G W+   P C A+ CP       G L+ ++    F+ G +  + C  G++L 
Sbjct: 3171 RIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN----FDWGFSISYICSPGYELS 3226

Query: 610  GPNNVECTTSGRWSATPPTCKGIASLPT----PGVQCPALTTPGQGTMYCRHHPGTFGFN 665
             P  + C  +G WS   P C     LP     PG+       P QG    +    +F + 
Sbjct: 3227 FPAVLTCVGNGTWSGEVPQC-----LPKFCGDPGI-------PAQG----KREGKSFIYQ 3270

Query: 666  TTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPAC---RAVKCSELHVNKPIAMNCSNLWG 722
            +   F CN  F L+G ST  C+  G W+  +P C       C    V +  + N  N +G
Sbjct: 3271 SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQN--NTFG 3328

Query: 723  NFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
             F  GS+  FHC +G LL GS    C  +  WS   P C
Sbjct: 3329 -FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPEC 3366



 Score =  239 bits (609), Expect = 1e-62
 Identities = 170/612 (27%), Positives = 251/612 (41%), Gaps = 83/612 (13%)

Query: 184  SCYPGFYG--------------------PECEYVRECGELELPQHVLMNCSHPLGN-FSF 222
            SC PG++G                    P C+ +  CGEL  P +      + +G   S+
Sbjct: 2684 SCDPGYHGLGPASIECLPNGTWSWRNERPYCQII-SCGELPTPPN-----GNKIGTQTSY 2737

Query: 223  NSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAF 282
             S   F C  G+ + G +  ECL+SG+W+    +CLA  C   ++   G +      + +
Sbjct: 2738 GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVI----GENY 2793

Query: 283  QHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLT 342
             ++ +  + C  GF L+G  V  C     W+   P C  V C H  +P  G         
Sbjct: 2794 GYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSG----N 2849

Query: 343  AFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPS 402
             F +     F C  GY ++G    +C  +  WS P P C+ ++C     P +   +    
Sbjct: 2850 GFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIE 2909

Query: 403  LRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCS 462
               F Y T   + C  G+ L G+ ++ C   GQW  P P C  + C    VP  A ++  
Sbjct: 2910 HGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGE 2969

Query: 463  HPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMT 522
                 + + S   ++C     L+G S   C   G+W+   P C            + T T
Sbjct: 2970 ----KYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSG----------DATGT 3015

Query: 523  CVQPLGSSSY----------KSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKC 572
            C  P G+  +          KST ++ CD GY L G E   C  +G WT   P C+A++C
Sbjct: 3016 CGDP-GTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQC 3074

Query: 573  PELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGI 632
                    G +   D        S+  +SC  G+ L GP+  +CT +G WS T P C  I
Sbjct: 3075 GNPGTTANGKVFRIDGT---TFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCT-I 3130

Query: 633  ASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFT--LIGDSTLSCRPSG 690
             S   PG+       P  G  Y   +    G N +  + C  G+T  L G    +C  +G
Sbjct: 3131 ISCGDPGI-------PANGLRYGDDY--VVGQNVS--YMCQPGYTMELNGSRIRTCTING 3179

Query: 691  QWTAVTPACRAVKCSELHVNKPIAMNCSNLWG-NFSYGSICSFHCLEGQLLNGSAQTACQ 749
             W+ V P CRAV C       P  ++   L G NF +G   S+ C  G  L+  A   C 
Sbjct: 3180 TWSGVMPTCRAVTCP-----TPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCV 3234

Query: 750  ENGHWSTTVPTC 761
             NG WS  VP C
Sbjct: 3235 GNGTWSGEVPQC 3246



 Score =  216 bits (550), Expect = 7e-56
 Identities = 144/519 (27%), Positives = 220/519 (42%), Gaps = 50/519 (9%)

Query: 258  LAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASG----VWT 313
            +A  C   + P  G +    S    Q  S   ++C+ GF LVG     C  S      W 
Sbjct: 2525 IAFYCSTPESPPHGYII---SQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWD 2581

Query: 314  APAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLR--CIDS 371
            AP P C+A+ C   +AP+ G +      T +  G+   + C  GYR+   ++    C   
Sbjct: 2582 APVPACQAISCGIPKAPTNGGI----LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSD 2637

Query: 372  GHWS--APLPTCEAISCEPLESPV--HGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADI 427
            G WS     P C  ++C  + S +  HG          ++Y T   F C  G+   G   
Sbjct: 2638 GTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSH-YEYKTKVVFSCDPGYHGLGPAS 2696

Query: 428  VRC--DNLGQWTAPAPVCQALQCQDLPV-PNEARVNCSHPFGAFRYQSVCSFTCNEGLLL 484
            + C  +    W    P CQ + C +LP  PN  ++     +G     S   FTC+ G +L
Sbjct: 2697 IECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYG-----STAIFTCDLGFML 2751

Query: 485  VGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSS-SYKSTCQFICDEG 543
            VG++V +CL++G W+     C A  C       NG     Q +G +  Y+ T  + C+ G
Sbjct: 2752 VGSAVRECLSSGLWSESETRCLAGHCGIPELIVNG-----QVIGENYGYRDTVVYQCNPG 2806

Query: 544  YSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGE-FNVGSTCHFSC 602
            + L G     C +   W+   P C  + C    +P  G      T G  FN      FSC
Sbjct: 2807 FRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGR-----TSGNGFNFNDVVTFSC 2861

Query: 603  DNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTF 662
            + G+ ++GP   +C  + +WS  PP CK + +   PG+       P       +   G F
Sbjct: 2862 NIGYLMQGPTKAQCQANRQWSHPPPMCK-VVNCSDPGI-------PANSKRESKIEHGNF 2913

Query: 663  GFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWG 722
             + T  ++ CN G+ L G S L C+P+GQW    P C  + C     +  +  N      
Sbjct: 2914 TYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCG----HPGVPPNAVLSGE 2969

Query: 723  NFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
             +++GS   + C   + L G +   CQ NGHWS + P C
Sbjct: 2970 KYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHC 3008



 Score =  196 bits (497), Expect = 1e-49
 Identities = 145/553 (26%), Positives = 228/553 (41%), Gaps = 42/553 (7%)

Query: 223  NSQCSFHCTDGYQVNGPSKLECLASGI----WTNKPPQCLAAQCPPLKIPERGNMTCLHS 278
            NS   + C  G+++ G S   C  S      W    P C A  C   K P  G +     
Sbjct: 2549 NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTD- 2607

Query: 279  AKAFQHQSSCSFSCEEGFALVGPEVVQ--CTASGVWTA--PAPVCKAVQCQHLEA--PSE 332
               +   +  ++ C +G+ L   E+    C + G W+     P C  V C  + +     
Sbjct: 2608 ---YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEH 2664

Query: 333  GTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWS--APLPTCEAISCEPLE 390
            G    V+  + + Y +   F C PGY   G   + C+ +G WS     P C+ ISC  L 
Sbjct: 2665 GRWRIVNG-SHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELP 2723

Query: 391  SPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQD 450
            +P +G+   + +     Y +   F C  GFML G+ +  C + G W+     C A  C  
Sbjct: 2724 TPPNGNKIGTQT----SYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCG- 2778

Query: 451  LPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPC 510
              +P E  VN       + Y+    + CN G  L+G+SV  C    NW+   P C  + C
Sbjct: 2779 --IP-ELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSC 2835

Query: 511  TPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAI 570
                SP  G  +        ++     F C+ GY + GP +  C  + +W+  PPMC+ +
Sbjct: 2836 GHPGSPIYGRTSG----NGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVV 2891

Query: 571  KCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCK 630
             C +   P     +     G F  G+   + C+ G+ L G + + C  +G+W    P C 
Sbjct: 2892 NCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2951

Query: 631  GIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSG 690
             I     PGV   A+ +   G  Y      TFG  +T ++ C    +L+G S+ +C+ +G
Sbjct: 2952 MI-DCGHPGVPPNAVLS---GEKY------TFG--STVHYSCTGKRSLLGQSSRTCQLNG 2999

Query: 691  QWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQE 750
             W+   P C          +     + S    NF   S   + C  G +L+GS +  C  
Sbjct: 3000 HWSGSQPHCSGDATGTCG-DPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLA 3058

Query: 751  NGHWSTTVPTCQA 763
            NG W+   P C+A
Sbjct: 3059 NGSWTGRQPECKA 3071



 Score =  163 bits (413), Expect = 5e-40
 Identities = 111/384 (28%), Positives = 165/384 (42%), Gaps = 28/384 (7%)

Query: 192  PECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWT 251
            PEC+ V +CG    P          +   +F+S   + C +GY ++GPS  +C A+G W+
Sbjct: 3067 PECKAV-QCGN---PGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWS 3122

Query: 252  NKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFA--LVGPEVVQCTAS 309
               P C    C    IP  G    L     +    + S+ C+ G+   L G  +  CT +
Sbjct: 3123 GTLPNCTIISCGDPGIPANG----LRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTIN 3178

Query: 310  GVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCI 369
            G W+   P C+AV C      S G ++     T F +G S  + C PGY +    +L C+
Sbjct: 3179 GTWSGVMPTCRAVTCPTPPQISNGRLEG----TNFDWGFSISYICSPGYELSFPAVLTCV 3234

Query: 370  DSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVR 429
             +G WS  +P C    C     P  G  +     ++F Y +  SF C   F+L G+    
Sbjct: 3235 GNGTWSGEVPQCLPKFCGDPGIPAQGKREG----KSFIYQSEVSFSCNFPFILVGSSTRI 3290

Query: 430  CDNLGQWTAPAPVC---QALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVG 486
            C   G W+  +P C       C++  VP     N  + FG F+  SV  F C +G LL G
Sbjct: 3291 CQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQN--NTFG-FQVGSVVQFHCKKGHLLQG 3347

Query: 487  ASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSL 546
            ++   CL    W+ + PEC    C     P+      V  +   S+  T  + C  G+ L
Sbjct: 3348 STTRTCLPDLTWSGIQPECIPHSCK---QPETPAHANVVGMDLPSHGYTLIYTCQPGFFL 3404

Query: 547  S-GPERLDCTRSGRWTDSPPMCEA 569
            + G E   C     WT   P+CEA
Sbjct: 3405 AGGTEHRVCRSDNTWTGKVPICEA 3428



 Score =  151 bits (381), Expect = 3e-36
 Identities = 116/394 (29%), Positives = 161/394 (40%), Gaps = 44/394 (11%)

Query: 383  AISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ----WTA 438
            A  C   ESP HG +    S    Q ++   + C  GF L G     C         W A
Sbjct: 2526 AFYCSTPESPPHGYII---SQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDA 2582

Query: 439  PAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQ--CLATG 496
            P P CQA+ C     P    +  +      R     ++ CN+G  L    +    C + G
Sbjct: 2583 PVPACQAISCGIPKAPTNGGILTTDYLVGTRV----TYFCNDGYRLSSKELTTAVCQSDG 2638

Query: 497  NWNS--VPPECQAIPCTPLLS--PQNGTMTCVQPLGSS-SYKSTCQFICDEGYSLSGPER 551
             W++    P C  + C  + S   ++G    V   GS   YK+   F CD GY   GP  
Sbjct: 2639 TWSNHNKTPRCVVVTCPSINSFILEHGRWRIVN--GSHYEYKTKVVFSCDPGYHGLGPAS 2696

Query: 552  LDCTRSGRWT--DSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLE 609
            ++C  +G W+  +  P C+ I C EL  P  G+   + T    + GST  F+CD GF L 
Sbjct: 2697 IECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQT----SYGSTAIFTCDLGFMLV 2752

Query: 610  GPNNVECTTSGRWSATPPTC-KGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTC 668
            G    EC +SG WS +   C  G   +P        L   GQ           +G+  T 
Sbjct: 2753 GSAVRECLSSGLWSESETRCLAGHCGIPE-------LIVNGQVI------GENYGYRDTV 2799

Query: 669  YFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGS 728
             + CN GF LIG S   C+    W+   P+C  V C   H   PI    S     F++  
Sbjct: 2800 VYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCG--HPGSPIYGRTSG--NGFNFND 2855

Query: 729  ICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762
            + +F C  G L+ G  +  CQ N  WS   P C+
Sbjct: 2856 VVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCK 2889



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 75/278 (26%), Positives = 119/278 (42%), Gaps = 32/278 (11%)

Query: 507  AIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSG----RWTD 562
            A  C+   SP +G +  +   G     S  ++ CD G+ L G     C +S      W  
Sbjct: 2526 AFYCSTPESPPHGYI--ISQTGGQ-LNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDA 2582

Query: 563  SPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPN--NVECTTSG 620
              P C+AI C    AP  G +  +D    + VG+   + C++G++L         C + G
Sbjct: 2583 PVPACQAISCGIPKAPTNGGILTTD----YLVGTRVTYFCNDGYRLSSKELTTAVCQSDG 2638

Query: 621  RWSATPPTCKGIASLPTPGVQCPALTT----PGQGTMYCRHHPGTFGFNTTCYFGCNAGF 676
             WS    T + +       V CP++ +     G+  +    H   + + T   F C+ G+
Sbjct: 2639 TWSNHNKTPRCVV------VTCPSINSFILEHGRWRIVNGSH---YEYKTKVVFSCDPGY 2689

Query: 677  TLIGDSTLSCRPSGQWT--AVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHC 734
              +G +++ C P+G W+     P C+ + C EL    P   N + +    SYGS   F C
Sbjct: 2690 HGLGPASIECLPNGTWSWRNERPYCQIISCGEL----PTPPNGNKIGTQTSYGSTAIFTC 2745

Query: 735  LEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEAL 772
              G +L GSA   C  +G WS +   C AG   I E +
Sbjct: 2746 DLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELI 2783



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 62/245 (25%), Positives = 91/245 (37%), Gaps = 64/245 (26%)

Query: 219  NFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHS 278
            NF +    S+ C+ GY+++ P+ L C+ +G W+ + PQCL   C    IP +G       
Sbjct: 3208 NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGK----RE 3263

Query: 279  AKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVC---KAVQCQHLEAPSEG-- 333
             K+F +QS  SFSC   F LVG     C A G W+  +P C       C++   P  G  
Sbjct: 3264 GKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQ 3323

Query: 334  --------------------------TMDCVHPLTAF----------------------- 344
                                      T  C+  LT                         
Sbjct: 3324 NNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVV 3383

Query: 345  -----AYGSSCKFECQPGYRVRGLDMLR-CIDSGHWSAPLPTCEAISCEPLESPVHGSMD 398
                 ++G +  + CQPG+ + G    R C     W+  +P CEA S   ++ P      
Sbjct: 3384 GMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGT 3443

Query: 399  CSPSL 403
             SP L
Sbjct: 3444 PSPKL 3448



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 111/485 (22%), Positives = 171/485 (35%), Gaps = 123/485 (25%)

Query: 261  QCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALV-GPEVVQCTASG---VWTAPA 316
            +CP   IP    +        FQ  SS S  CEEGF    G E + C       +W+   
Sbjct: 793  ECPDPGIP----INARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLI 848

Query: 317  PVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKF--ECQPGYRVR----------GLD 364
            P C A    H  APS   +    P   +    +C++  E +PG+ ++            D
Sbjct: 849  PKCGAPCGGHFSAPSGVILSPGWP-GYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYD 907

Query: 365  MLRCIDSGHWSAPL-----------------------------------------PTCEA 383
            +L   D  +  +PL                                          T   
Sbjct: 908  VLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNT 967

Query: 384  ISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC 443
             SC     PVHG          F   +  SF C  G+ L   + + C+    W+ P P C
Sbjct: 968  YSCLDPGIPVHGRRYGHD----FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1023

Query: 444  QALQCQDLPVPNEARVNCSHPFGAFRYQSV-CSFTCNEGLLLVGASVLQCLATGNWNSVP 502
             AL   D+  P+   ++  +P   F   S+ C++T +   +  G  V       N+++  
Sbjct: 1024 DALCGGDVRGPSGTILSPGYP--EFYPNSLNCTWTVD---VTHGKGV-----QFNFHTFH 1073

Query: 503  PECQAIPCTPLLSPQNGTMTCVQPLGS---------------SSYKSTCQFICDEGYSLS 547
             E        LL  +NG+ T  QPL                  ++++  +FI D   S  
Sbjct: 1074 LEDHH---DYLLITENGSFT--QPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYE 1128

Query: 548  GPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFK 607
            G    + T S  +   P       C +   P+ GS         F +G T  FSC +G++
Sbjct: 1129 G---FNITFS-EYNLEP-------CEDPGIPQYGSR----IGFNFGIGDTLTFSCSSGYR 1173

Query: 608  LEGPNNVECTTSGR--WSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFN 665
            LEG + + C   GR  WSA  P C           +C A  T  +G +   ++P  +  N
Sbjct: 1174 LEGTSEIICLGGGRRVWSAPLPRCV---------AECGASATNNEGILLSPNYPLNYENN 1224

Query: 666  TTCYF 670
              C +
Sbjct: 1225 HECIY 1229



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 106/456 (23%), Positives = 169/456 (37%), Gaps = 87/456 (19%)

Query: 175  LETIGNYTCSCYPGFYGPECEYVRE-CGELELPQHVLMNCSHPLG-NFSFNSQCSFHCTD 232
            L  I +++ S Y GF     EY  E C +  +PQ+        +G NF      +F C+ 
Sbjct: 1117 LRFISDFSIS-YEGFNITFSEYNLEPCEDPGIPQY-----GSRIGFNFGIGDTLTFSCSS 1170

Query: 233  GYQVNGPSKLECLASG--IWTNKPPQCLAAQC-------------PPLKIPERGNMTCLH 277
            GY++ G S++ CL  G  +W+   P+C+A +C             P   +    N  C++
Sbjct: 1171 GYRLEGTSEIICLGGGRRVWSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENNHECIY 1229

Query: 278  SAKAFQHQ----SSCSFSCEEGFALVGPEVVQCTAS--GVWTAPAPVCKAVQCQ------ 325
            S +    +    S+ +F   +G  L   +    T    G +T  +     +         
Sbjct: 1230 SIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWL 1289

Query: 326  HLEAPSEGTMD-------------CVHP-LTAFAY---------GSSCKFECQPGYRVRG 362
               + +EGT +             C  P +  F Y         GS+  + C PGY + G
Sbjct: 1290 EFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHG 1349

Query: 363  LDMLRCI--DSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGF 420
              +L+C+  +   W  PLP+C A      +    G +  SP    F YD N   RC    
Sbjct: 1350 SSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRI-LSPGY-PFPYDNN--LRCMWMI 1405

Query: 421  MLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARV----NCSHPFGAFRYQSVCSF 476
             +   +IV    L   T  +     L+  D P  N+  +        P G     ++ + 
Sbjct: 1406 EVDPGNIVSLQFLAFDTEASH--DILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTI 1463

Query: 477  TCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTC 536
              +    +  +      A    +SV   C+  P  P+   +NG               T 
Sbjct: 1464 QFDTDFYISKSG----FAIQFSSSVATACRD-PGVPMNGTRNG--------DGREPGDTV 1510

Query: 537  QFICDEGYSLSGPERLDCTRSGR---WTDSPPMCEA 569
             F CD GY L G ER+ C +      W  SPP+C A
Sbjct: 1511 VFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA 1546



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 110/515 (21%), Positives = 174/515 (33%), Gaps = 85/515 (16%)

Query: 186  YPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECL 245
            Y GF+    EY  +  E       +MN +    ++   S  +++C  GY + G S L C+
Sbjct: 1646 YTGFH---LEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCI 1702

Query: 246  ASGI----WTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCE--EGFALV 299
                    W    P C  A C        G +   +  K +    +C +S    + F + 
Sbjct: 1703 MGDDGRPGWNRALPSC-HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVF 1761

Query: 300  GPEVVQCTA--SGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPG 357
            G  V   T+    V     P  ++     L     G      PL++     + +F     
Sbjct: 1762 GQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGES---LPLSS-GNQITIRFTSVGP 1817

Query: 358  YRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCA 417
               +G   +           +P   +  C  +  P  G    +     F   ++  F C 
Sbjct: 1818 ITAKGFHFVY--------QAVPRTSSTQCSSVPEPRFGRRIGNE----FAVGSSVLFDCN 1865

Query: 418  EGFMLRGADIVRCD----NLGQWTAPAPVCQALQCQDL-------------PVPNEARVN 460
             G++L G+  +RC+    +L QW    P C  + C  +             P P +  +N
Sbjct: 1866 PGYILHGSIAIRCETVPNSLAQWNDSLPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLN 1924

Query: 461  CSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGT 520
            C           V   T  EG   +   V+      NW+S+          P L   +GT
Sbjct: 1925 C-----------VWKITVPEGAG-IQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGT 1972

Query: 521  MTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQ 580
             T    L S+S      F  D   S +G   L+ T  G   DS        CPE   P  
Sbjct: 1973 -TIPHLLNSTSNNLYLNFQSDISVSAAG-FHLEYTAIG--LDS--------CPEPQTPSS 2020

Query: 581  GSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTS--GRWSATPPTCKGIASLPTP 638
            G +   D    + VG    F CD G+ L+G +++ C      RW+   P C         
Sbjct: 2021 G-IKIGD---RYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICL-------- 2068

Query: 639  GVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCN 673
              QC    +   G +     PG +  +  C +  N
Sbjct: 2069 -AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTIN 2102



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 121/600 (20%), Positives = 189/600 (31%), Gaps = 168/600 (28%)

Query: 228  FHCTDGYQVNGPSKLECLASG---IWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQH 284
            F C  GY++ G  ++ C+       W   PP C+A  C        G +   +    + H
Sbjct: 1512 FQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAP-CGGNLTGSSGFILSPNFPHPYPH 1570

Query: 285  QSSC-----------------SFSCEEGFALV----GPEVVQCTASGVWTAPAP--VCKA 321
               C                 SFS E  +  +    GP+           +  P  +  +
Sbjct: 1571 SRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESS 1630

Query: 322  VQCQHLEAPSEGTMD---------------CVHPLTA---------FAYGSSCKFECQPG 357
                HL   S+G++                C  P            +  GS+  + C  G
Sbjct: 1631 SNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAG 1690

Query: 358  YRVRGLDMLRCI--DSGH--WSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCS 413
            Y ++G   L CI  D G   W+  LP+C A  C    +   G++      + +    NC 
Sbjct: 1691 YVLQGYSTLTCIMGDDGRPGWNRALPSCHA-PCGSRSTGSEGTVLSPNYPKNYSVGHNCV 1749

Query: 414  FRCA--EGFMLRGADI-------------------------------------------- 427
            +  A  + F++ G  +                                            
Sbjct: 1750 YSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQIT 1809

Query: 428  VRCDNLGQWTAPA--------PVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCN 479
            +R  ++G  TA          P   + QC  +P P   R         F   S   F CN
Sbjct: 1810 IRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGR----RIGNEFAVGSSVLFDCN 1865

Query: 480  EGLLLVGASVLQCLATGN----WNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKST 535
             G +L G+  ++C    N    WN   P C  +PC  +L+ + GT               
Sbjct: 1866 PGYILHGSIAIRCETVPNSLAQWNDSLPTC-IVPCGGILTKRKGT--------------- 1909

Query: 536  CQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPEL-FAPEQG--SLDCSD----- 587
               I   GY       L+C     W  + P    I+   + FA E    SLD  D     
Sbjct: 1910 ---ILSPGYPEPYDNNLNCV----WKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNN 1962

Query: 588  --TRGEFNVGSTCHF--SCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCP 643
                G ++  +  H   S  N   L   +++  + +G       T  G+ S P P     
Sbjct: 1963 APRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAG--FHLEYTAIGLDSCPEP----- 2015

Query: 644  ALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPS--GQWTAVTPACRA 701
               TP  G          +       F C+ G++L G S ++C P    +W    P C A
Sbjct: 2016 --QTPSSGIKI----GDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLA 2069



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 91/450 (20%), Positives = 161/450 (35%), Gaps = 80/450 (17%)

Query: 276  LHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTM 335
            +     F ++    F C+ GF L+G + + C  +  W+A  P+C      +  AP    +
Sbjct: 634  IREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVL 693

Query: 336  DCVHPLTAFAYGSSCKFEC--QPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPV 393
               +P   +    +C +     PG R+         +     +          +  ESP+
Sbjct: 694  SPDYP-EGYGNNLNCIWTIISDPGSRIH-----LSFNDFDLESQFDFLAVKDGDSPESPI 747

Query: 394  HGSM---DCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQD 450
             G+    +    L +  +     F+       RG +I   +  G            +C D
Sbjct: 748  LGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITY-NTFGH----------NECPD 796

Query: 451  LPVPNEARVNCSHPFGA-FRYQSVCSFTCNEGLLLV-GASVLQCLATGN---WNSVPPEC 505
              +P  AR      FG  F+  S  S  C EG +   G   + C+       W+ + P+C
Sbjct: 797  PGIPINAR-----RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 851

Query: 506  QAIPCTPLLSPQNGTMTCVQPLGSSSYKST--CQFI--CDEGYSLSGP-ERLDCTRSGRW 560
             A PC    S  +G +  + P     YK +  C+++   + G+S+    ER     +   
Sbjct: 852  GA-PCGGHFSAPSGVI--LSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNY-- 906

Query: 561  TDSPPMCEAIKCPELFAPEQGSLD--------CSDTRGEFNVGSTCHFSCDNGFKLEGPN 612
                 + E    P L +P  GS +         S +   + + +T +   +NGFK+    
Sbjct: 907  ----DVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKI---- 958

Query: 613  NVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGC 672
            + E  T   +S   P       +P  G                R +   F   +T  F C
Sbjct: 959  HYESVTVNTYSCLDP------GIPVHG----------------RRYGHDFSIGSTVSFSC 996

Query: 673  NAGFTLIGDSTLSCRPSGQWTAVTPACRAV 702
            ++G+ L  +  L C  +  W+   P C A+
Sbjct: 997  DSGYRLSHEEPLLCEKNHWWSHPLPTCDAL 1026



 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 96/440 (21%), Positives = 160/440 (36%), Gaps = 73/440 (16%)

Query: 282  FQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHP- 340
            F   S+ SFSC+ G+ L   E + C  +  W+ P P C A+    +  PS   +   +P 
Sbjct: 986  FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPE 1045

Query: 341  ----------LTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEP-L 389
                           +G   +F     +     D L   ++G ++ PL         P +
Sbjct: 1046 FYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTI 1105

Query: 390  ESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQ 449
             + ++G+      LR F  D + S+   EGF +  ++     NL              C+
Sbjct: 1106 NAGLYGNFRAQ--LR-FISDFSISY---EGFNITFSEY----NLEP------------CE 1143

Query: 450  DLPVPNE-ARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGN--WNSVPPECQ 506
            D  +P   +R+  +   G        +F+C+ G  L G S + CL  G   W++  P C 
Sbjct: 1144 DPGIPQYGSRIGFNFGIG-----DTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198

Query: 507  AIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPM 566
            A  C    +   G +  + P    +Y++  + I    YS+         ++G+  +    
Sbjct: 1199 A-ECGASATNNEGIL--LSPNYPLNYENNHECI----YSIQ-------VQAGKGINISAR 1244

Query: 567  CEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHF---SCDNGFKLEGPNNVECTTSGRWS 623
               +   ++     G    +   G F   S       S  N   LE  ++ E T  G   
Sbjct: 1245 TFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQL 1304

Query: 624  ATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDST 683
                T   ++    PG+         QG     H  G+     T  +GCN G+TL G S 
Sbjct: 1305 VY--TSFELSHCEDPGIPQFGYKISDQG-----HFAGS-----TIIYGCNPGYTLHGSSL 1352

Query: 684  LSCRPSGQ--WTAVTPACRA 701
            L C    +  W    P+C A
Sbjct: 1353 LKCMTGERRAWDYPLPSCIA 1372



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 100/445 (22%), Positives = 153/445 (34%), Gaps = 86/445 (19%)

Query: 347  GSSCKFECQPGYRVRGLDMLRCIDSGH---WSAPLPTCEA------------ISCEPLES 391
            G +  F+C PGY ++G + + CI   +   W    P C A            I       
Sbjct: 1507 GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPH 1566

Query: 392  PVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAP---APVCQALQC 448
            P   S DC  ++       N  +  +  F+    +    D L  +  P   +P+  + Q 
Sbjct: 1567 PYPHSRDCDWTITV-----NADYVISLAFISFSIE-PNYDFLYIYDGPDSNSPLIGSFQD 1620

Query: 449  QDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQ--CLATGNWNSVPPECQ 506
              LP   E+  N  H   AFR     S+T   G  L   + L+  C   GN         
Sbjct: 1621 SKLPERIESSSNTMHL--AFRSDGSVSYT---GFHLEYKAKLRESCFDPGNI-------- 1667

Query: 507  AIPCTPLLSPQNGTMTCVQPLGSSSYK--STCQFICDEGYSLSGPERLDCTRS--GR--W 560
                       NGT           YK  ST  + CD GY L G   L C     GR  W
Sbjct: 1668 ----------MNGTRL------GMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGW 1711

Query: 561  TDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSG 620
              + P C A  C       +G++   +    ++VG  C +S      +  P   E    G
Sbjct: 1712 NRALPSCHA-PCGSRSTGSEGTVLSPNYPKNYSVGHNCVYS------IAVPK--EFVVFG 1762

Query: 621  RWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIG 680
            ++     +   +  +     Q  +L +   G+      P + G   T  F      T  G
Sbjct: 1763 QFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKG 1822

Query: 681  DSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLL 740
               +       + AV P   + +CS +    P       +   F+ GS   F C  G +L
Sbjct: 1823 FHFV-------YQAV-PRTSSTQCSSV----PEPRFGRRIGNEFAVGSSVLFDCNPGYIL 1870

Query: 741  NGSAQTACQ----ENGHWSTTVPTC 761
            +GS    C+        W+ ++PTC
Sbjct: 1871 HGSIAIRCETVPNSLAQWNDSLPTC 1895



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 51/217 (23%), Positives = 80/217 (36%), Gaps = 46/217 (21%)

Query: 591  EFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQ 650
            +F++GST  FSCD+G++L     + C  +  WS   PTC  +      G     L+ PG 
Sbjct: 985  DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILS-PGY 1043

Query: 651  GTMY-----------CRHHPGT-FGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTA--VT 696
               Y             H  G  F F+T  +   +  + LI ++    +P  + T   + 
Sbjct: 1044 PEFYPNSLNCTWTVDVTHGKGVQFNFHTF-HLEDHHDYLLITENGSFTQPLARLTGSDLP 1102

Query: 697  PACRA------------------------VKCSELHV----NKPIAMNCSNLWGNFSYGS 728
            P   A                        +  SE ++    +  I    S +  NF  G 
Sbjct: 1103 PTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGD 1162

Query: 729  ICSFHCLEGQLLNGSAQTACQENGH--WSTTVPTCQA 763
              +F C  G  L G+++  C   G   WS  +P C A
Sbjct: 1163 TLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA 1199



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 64/261 (24%), Positives = 98/261 (37%), Gaps = 47/261 (18%)

Query: 531  SYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPE----------- 579
            S  ST  F CD GY LS  E L C ++  W+   P C+A+   ++  P            
Sbjct: 987  SIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEF 1046

Query: 580  -QGSLDCSDT------RG-EFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSAT--PPTC 629
               SL+C+ T      +G +FN   T H    + + L   N        R + +  PPT 
Sbjct: 1047 YPNSLNCTWTVDVTHGKGVQFNF-HTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTI 1105

Query: 630  K----GIASLPTPGVQCPALTTPGQGTMYCRHH------PG----------TFGFNTTCY 669
                 G        +   +++  G    +  ++      PG           FG   T  
Sbjct: 1106 NAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLT 1165

Query: 670  FGCNAGFTLIGDSTLSCRPSGQ--WTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYG 727
            F C++G+ L G S + C   G+  W+A  P C A +C     N    +   N   N+   
Sbjct: 1166 FSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENN 1224

Query: 728  SIC--SFHCLEGQLLNGSAQT 746
              C  S     G+ +N SA+T
Sbjct: 1225 HECIYSIQVQAGKGINISART 1245



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 53/240 (22%), Positives = 74/240 (30%), Gaps = 66/240 (27%)

Query: 262 CPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQC----TASGVWTAPAP 317
           CP    PE G          F   S+  FSC+E + L G + + C         W+   P
Sbjct: 446 CPDPGEPENGKRI----GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRP 501

Query: 318 VCKAVQC-QHLEAPS------------EGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLD 364
           VCK   C  +L+ PS            +    CV  +TA       +   +      G D
Sbjct: 502 VCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYD 561

Query: 365 MLRCIDSGHWSAP--------------------------LPTCEAI-------------- 384
            L   D G    P                          L T E++              
Sbjct: 562 TLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEK 621

Query: 385 -SCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC 443
            SC    +P++G  +       F       F C  GF L G   + C    QW+A  P+C
Sbjct: 622 ESCGDPGTPLYGIREGD----GFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 677



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 23/63 (36%), Positives = 30/63 (47%), Gaps = 8/63 (12%)

Query: 572 CPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVEC----TTSGRWSATPP 627
           CP+   PE G    SD    F++GST  FSCD  + L+G  ++ C         WS   P
Sbjct: 446 CPDPGEPENGKRIGSD----FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRP 501

Query: 628 TCK 630
            CK
Sbjct: 502 VCK 504



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 64/265 (24%), Positives = 95/265 (35%), Gaps = 28/265 (10%)

Query: 442  VCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCL--ATGNWN 499
            V QA Q Q  P P   R N       F      SF C  G  L+G S L CL   + NWN
Sbjct: 2175 VYQAYQLQSCPDPRPFR-NGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWN 2233

Query: 500  SVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR 559
               P C+A+ C   ++  NGT      + S  Y        D  + +  P       +  
Sbjct: 2234 HPLPRCEAL-CGGNITAMNGT------IYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFT 2286

Query: 560  WTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTS 619
               + P+ + I   +   P+Q S       G  N      +S  N   ++   + + TTS
Sbjct: 2287 VLQTEPIYDFITVWD--GPDQNSPQIGQFSG--NTALESVYSTSNQILIK--FHSDFTTS 2340

Query: 620  GRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLI 679
            G +  +    +     P P V    + T              F       + C  GFTL+
Sbjct: 2341 GFFVLSYHAYQLRVCQPPPPVPNAEILT----------EDDEFEIGDIIRYQCLPGFTLV 2390

Query: 680  GDSTLSCRPSG--QWTAVTPACRAV 702
            G++ L+CR     Q     P C+ +
Sbjct: 2391 GNAILTCRLGERLQMDGAPPVCQVL 2415



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 19/43 (44%), Positives = 25/43 (58%), Gaps = 2/43 (4%)

Query: 344  FAYGSSCKFECQPGYRVRGLDMLRCID--SGHWSAPLPTCEAI 384
            F  G +  FEC PGY + G   L C+   S +W+ PLP CEA+
Sbjct: 2200 FTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL 2242



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 25/88 (28%), Positives = 39/88 (44%), Gaps = 10/88 (11%)

Query: 516 PQNGTMTCVQPLGSS-SYKSTCQFICDEGYSLSGPERLDCTRSGR----WTDSPPMCEAI 570
           P+NG     + +GS  S  ST QF CDE Y L G + + C R       W+D  P+C+  
Sbjct: 452 PENG-----KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVK 506

Query: 571 KCPELFAPEQGSLDCSDTRGEFNVGSTC 598
            C        G+    +   +++  + C
Sbjct: 507 TCGSNLQGPSGTFTSPNFPFQYDSNAQC 534



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 101/443 (22%), Positives = 154/443 (34%), Gaps = 89/443 (20%)

Query: 219  NFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHS 278
            +FS  S  SF C  GY+++    L C  +  W++  P C A     ++ P    ++    
Sbjct: 985  DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILS---- 1040

Query: 279  AKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQ----HLEAPSEGT 334
                            G+    P  + CT    WT      K VQ      HLE      
Sbjct: 1041 ---------------PGYPEFYPNSLNCT----WTVDVTHGKGVQFNFHTFHLE------ 1075

Query: 335  MDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDS---GHWSAPLP------------ 379
             D    L     GS      QP  R+ G D+   I++   G++ A L             
Sbjct: 1076 -DHHDYLLITENGSF----TQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGF 1130

Query: 380  --TCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ-- 435
              T    + EP E P             F      +F C+ G+ L G   + C   G+  
Sbjct: 1131 NITFSEYNLEPCEDPGIPQYGSRIGFN-FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRV 1189

Query: 436  WTAPAPVCQALQCQDLPVPNEA-RVNCSHPFG-AFRYQSVCSFTCNEGLLLVGASVLQCL 493
            W+AP P C A +C      NE   ++ ++P      ++ + S     G  +  ++    L
Sbjct: 1190 WSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL 1248

Query: 494  ATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFI-----CDEGYSLSG 548
            A G+   +         T LL    G       L S+S +   +F       DEG+ L  
Sbjct: 1249 AQGDVLKIYDGKD--KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVY 1306

Query: 549  PERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKL 608
                               E   C +   P+ G    SD +G F  GST  + C+ G+ L
Sbjct: 1307 TS----------------FELSHCEDPGIPQFG-YKISD-QGHF-AGSTIIYGCNPGYTL 1347

Query: 609  EGPNNVECTTSGR--WSATPPTC 629
             G + ++C T  R  W    P+C
Sbjct: 1348 HGSSLLKCMTGERRAWDYPLPSC 1370



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 46/241 (19%), Positives = 75/241 (31%), Gaps = 73/241 (30%)

Query: 406 FQYDTNCSFRCAEGFMLRGADIVRCDNLGQ----WTAPAPVCQALQC------------- 448
           F   +   F C E ++L+GA  + C  + +    W+   PVC+   C             
Sbjct: 462 FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTS 521

Query: 449 QDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVG---------------ASVLQCL 493
            + P   ++   C     A     V      E  L +G                +VLQ L
Sbjct: 522 PNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVL 581

Query: 494 ATG-------------------------------NWNSVPPECQAIPCTPLLSPQNGTMT 522
            TG                               N+  +  E    P TPL   + G   
Sbjct: 582 -TGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREG--- 637

Query: 523 CVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGS 582
                   S +   +F C  G+ L G + + C  + +W+ + P+C    C   F    G+
Sbjct: 638 -----DGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC-IFPCLSNFTAPMGT 691

Query: 583 L 583
           +
Sbjct: 692 V 692



 Score = 35.4 bits (80), Expect = 0.22
 Identities = 15/38 (39%), Positives = 17/38 (44%)

Query: 724 FSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
           FS   +  F C  G  L G     CQEN  WS  +P C
Sbjct: 640 FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 677



 Score = 35.0 bits (79), Expect = 0.29
 Identities = 46/223 (20%), Positives = 73/223 (32%), Gaps = 63/223 (28%)

Query: 595  GSTCHFSCDNGFKLEGPNNVECTTSGR---WSATPPTCKGIASLPTPGVQCPALTTPGQG 651
            G T  F CD G++L+G   + C        W  +PP C            C    T   G
Sbjct: 1507 GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI---------APCGGNLTGSSG 1557

Query: 652  TMYCRHHPGTFGFNTTC------------------------------YFGCNAGFTLIG- 680
             +   + P  +  +  C                              Y G ++   LIG 
Sbjct: 1558 FILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGS 1617

Query: 681  --DSTLSCRPSGQWTAVTPACRA--------------VKCSELHVNKPIAMNCSNLWGNF 724
              DS L  R       +  A R+               K  E   +    MN + L  ++
Sbjct: 1618 FQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDY 1677

Query: 725  SYGSICSFHCLEGQLLNGSAQTAC--QENGH--WSTTVPTCQA 763
              GS  +++C  G +L G +   C   ++G   W+  +P+C A
Sbjct: 1678 KLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA 1720



 Score = 34.7 bits (78), Expect = 0.37
 Identities = 23/87 (26%), Positives = 34/87 (39%), Gaps = 18/87 (20%)

Query: 342 TAFAYGSSCKFECQPGYRVRGLDMLRCI----DSGHWSAPLPTCEA-------------- 383
           T F  G   ++ C  GY + G   L CI    ++  W  P+P C A              
Sbjct: 152 TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGI 211

Query: 384 ISCEPLESPVHGSMDCSPSLRAFQYDT 410
           IS     +  H + DC+ ++ A   DT
Sbjct: 212 ISSPSFPNEYHNNADCTWTIVAEPGDT 238



 Score = 30.4 bits (67), Expect = 7.0
 Identities = 18/46 (39%), Positives = 23/46 (50%), Gaps = 3/46 (6%)

Query: 217  LGN-FSFNSQCSFHCTDGYQVNGPSKLECL--ASGIWTNKPPQCLA 259
            +GN F+     SF C  GY + G S L CL   S  W +  P+C A
Sbjct: 2196 IGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEA 2241



 Score = 30.0 bits (66), Expect = 9.2
 Identities = 16/51 (31%), Positives = 21/51 (41%), Gaps = 4/51 (7%)

Query: 716 NCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGH----WSTTVPTCQ 762
           N   +  +FS GS   F C E  +L G+    CQ        WS   P C+
Sbjct: 454 NGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504


>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
          Length = 3707

 Score =  258 bits (660), Expect = 1e-68
 Identities = 163/561 (29%), Positives = 248/561 (44%), Gaps = 46/561 (8%)

Query: 210  LMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWT--NKPPQCLAAQCPPLKI 267
            ++N SH    + + ++  F C  GY   GP+ +ECL +G W+  N+ P C    C  L  
Sbjct: 2709 IVNGSH----YEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPT 2764

Query: 268  PERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHL 327
            P  GN     ++    + S+  F+C+ GF LVG  V +C +SG+W+     C A  C   
Sbjct: 2765 PPNGNKIGTQTS----YGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIP 2820

Query: 328  EAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCE 387
            E    G +   +    + Y  +  ++C PG+R+ G  +  C    +WS  LP+C  +SC 
Sbjct: 2821 ELIVNGQVIGEN----YGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCG 2876

Query: 388  PLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQ 447
               SP++G      S   F ++   +F C  G++++G    +C    QW+ P P+C+ + 
Sbjct: 2877 HPGSPIYG----RTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVN 2932

Query: 448  CQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQA 507
            C D  +P  ++       G F Y +V  + CN G  L G+SVL C   G W+   PEC  
Sbjct: 2933 CSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIM 2992

Query: 508  IPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMC 567
            I C     P N  ++  +     ++ ST  + C    SL G     C  +G W+ S P C
Sbjct: 2993 IDCGHPGVPPNAVLSGEK----YTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHC 3048

Query: 568  EAI---KCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSA 624
                   C +   P  GS   S+    F   ST  ++CD G+ L G     C  +G W+ 
Sbjct: 3049 SGDATGTCGDPGTPGHGSRQESN----FRTKSTVRYACDTGYILHGSEERTCLANGSWTG 3104

Query: 625  TPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTL 684
              P CK         VQC    T   G ++     GT  F+++  + C  G+ L G S  
Sbjct: 3105 RQPECK--------AVQCGNPGTTANGKVF--RIDGT-TFSSSVIYSCMEGYILSGPSVR 3153

Query: 685  SCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQL--LNG 742
             C  +G W+   P C  + C +      I  N      ++  G   S+ C  G    LNG
Sbjct: 3154 QCTANGTWSGTLPNCTIISCGD----PGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNG 3209

Query: 743  SAQTACQENGHWSTTVPTCQA 763
            S    C  NG WS  +PTC+A
Sbjct: 3210 SRIRTCTINGTWSGVMPTCRA 3230



 Score =  242 bits (617), Expect = 1e-63
 Identities = 164/579 (28%), Positives = 241/579 (41%), Gaps = 59/579 (10%)

Query: 204  ELPQHVLMNCSHP--------LGN-FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKP 254
            +LP  V ++C HP         GN F+FN   +F C  GY + GP+K +C A+  W++ P
Sbjct: 2866 QLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPP 2925

Query: 255  PQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTA 314
            P C    C    IP             F + +   + C  G+ L G  V+ C  +G W  
Sbjct: 2926 PMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDK 2985

Query: 315  PAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHW 374
            P P C  + C H   P    +        + +GS+  + C     + G     C  +GHW
Sbjct: 2986 PLPECIMIDCGHPGVPPNAVLSG----EKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHW 3041

Query: 375  SAPLPTCEAIS---CEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCD 431
            S   P C   +   C    +P HGS   S     F+  +   + C  G++L G++   C 
Sbjct: 3042 SGSQPHCSGDATGTCGDPGTPGHGSRQESN----FRTKSTVRYACDTGYILHGSEERTCL 3097

Query: 432  NLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQ 491
              G WT   P C+A+QC +       +V          + S   ++C EG +L G SV Q
Sbjct: 3098 ANGSWTGRQPECKAVQCGNPGTTANGKV---FRIDGTTFSSSVIYSCMEGYILSGPSVRQ 3154

Query: 492  CLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYS--LSGP 549
            C A G W+   P C  I C     P NG    ++            ++C  GY+  L+G 
Sbjct: 3155 CTANGTWSGTLPNCTIISCGDPGIPANG----LRYGDDYVVGQNVSYMCQPGYTMELNGS 3210

Query: 550  ERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLE 609
                CT +G W+   P C A+ CP       G L+ ++    F+ G +  + C  G++L 
Sbjct: 3211 RIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN----FDWGFSISYICSPGYELS 3266

Query: 610  GPNNVECTTSGRWSATPPTCKGIASLPT----PGVQCPALTTPGQGTMYCRHHPGTFGFN 665
             P  + C  +G WS   P C     LP     PG+       P QG    +    +F + 
Sbjct: 3267 FPAVLTCVGNGTWSGEVPQC-----LPKFCGDPGI-------PAQG----KREGKSFIYQ 3310

Query: 666  TTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPAC---RAVKCSELHVNKPIAMNCSNLWG 722
            +   F CN  F L+G ST  C+  G W+  +P C       C    V +  + N  N +G
Sbjct: 3311 SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQN--NTFG 3368

Query: 723  NFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
             F  GS+  FHC +G LL GS    C  +  WS   P C
Sbjct: 3369 -FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPEC 3406



 Score =  239 bits (609), Expect = 1e-62
 Identities = 170/612 (27%), Positives = 251/612 (41%), Gaps = 83/612 (13%)

Query: 184  SCYPGFYG--------------------PECEYVRECGELELPQHVLMNCSHPLGN-FSF 222
            SC PG++G                    P C+ +  CGEL  P +      + +G   S+
Sbjct: 2724 SCDPGYHGLGPASIECLPNGTWSWRNERPYCQII-SCGELPTPPN-----GNKIGTQTSY 2777

Query: 223  NSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAF 282
             S   F C  G+ + G +  ECL+SG+W+    +CLA  C   ++   G +      + +
Sbjct: 2778 GSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVI----GENY 2833

Query: 283  QHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLT 342
             ++ +  + C  GF L+G  V  C     W+   P C  V C H  +P  G         
Sbjct: 2834 GYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSG----N 2889

Query: 343  AFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPS 402
             F +     F C  GY ++G    +C  +  WS P P C+ ++C     P +   +    
Sbjct: 2890 GFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIE 2949

Query: 403  LRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCS 462
               F Y T   + C  G+ L G+ ++ C   GQW  P P C  + C    VP  A ++  
Sbjct: 2950 HGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGE 3009

Query: 463  HPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMT 522
                 + + S   ++C     L+G S   C   G+W+   P C            + T T
Sbjct: 3010 ----KYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSG----------DATGT 3055

Query: 523  CVQPLGSSSY----------KSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKC 572
            C  P G+  +          KST ++ CD GY L G E   C  +G WT   P C+A++C
Sbjct: 3056 CGDP-GTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQC 3114

Query: 573  PELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGI 632
                    G +   D        S+  +SC  G+ L GP+  +CT +G WS T P C  I
Sbjct: 3115 GNPGTTANGKVFRIDGT---TFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCT-I 3170

Query: 633  ASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFT--LIGDSTLSCRPSG 690
             S   PG+       P  G  Y   +    G N +  + C  G+T  L G    +C  +G
Sbjct: 3171 ISCGDPGI-------PANGLRYGDDY--VVGQNVS--YMCQPGYTMELNGSRIRTCTING 3219

Query: 691  QWTAVTPACRAVKCSELHVNKPIAMNCSNLWG-NFSYGSICSFHCLEGQLLNGSAQTACQ 749
             W+ V P CRAV C       P  ++   L G NF +G   S+ C  G  L+  A   C 
Sbjct: 3220 TWSGVMPTCRAVTCP-----TPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCV 3274

Query: 750  ENGHWSTTVPTC 761
             NG WS  VP C
Sbjct: 3275 GNGTWSGEVPQC 3286



 Score =  216 bits (550), Expect = 7e-56
 Identities = 144/519 (27%), Positives = 220/519 (42%), Gaps = 50/519 (9%)

Query: 258  LAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASG----VWT 313
            +A  C   + P  G +    S    Q  S   ++C+ GF LVG     C  S      W 
Sbjct: 2565 IAFYCSTPESPPHGYII---SQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWD 2621

Query: 314  APAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLR--CIDS 371
            AP P C+A+ C   +AP+ G +      T +  G+   + C  GYR+   ++    C   
Sbjct: 2622 APVPACQAISCGIPKAPTNGGI----LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSD 2677

Query: 372  GHWS--APLPTCEAISCEPLESPV--HGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADI 427
            G WS     P C  ++C  + S +  HG          ++Y T   F C  G+   G   
Sbjct: 2678 GTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSH-YEYKTKVVFSCDPGYHGLGPAS 2736

Query: 428  VRC--DNLGQWTAPAPVCQALQCQDLPV-PNEARVNCSHPFGAFRYQSVCSFTCNEGLLL 484
            + C  +    W    P CQ + C +LP  PN  ++     +G     S   FTC+ G +L
Sbjct: 2737 IECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYG-----STAIFTCDLGFML 2791

Query: 485  VGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSS-SYKSTCQFICDEG 543
            VG++V +CL++G W+     C A  C       NG     Q +G +  Y+ T  + C+ G
Sbjct: 2792 VGSAVRECLSSGLWSESETRCLAGHCGIPELIVNG-----QVIGENYGYRDTVVYQCNPG 2846

Query: 544  YSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGE-FNVGSTCHFSC 602
            + L G     C +   W+   P C  + C    +P  G      T G  FN      FSC
Sbjct: 2847 FRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGR-----TSGNGFNFNDVVTFSC 2901

Query: 603  DNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTF 662
            + G+ ++GP   +C  + +WS  PP CK + +   PG+       P       +   G F
Sbjct: 2902 NIGYLMQGPTKAQCQANRQWSHPPPMCK-VVNCSDPGI-------PANSKRESKIEHGNF 2953

Query: 663  GFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWG 722
             + T  ++ CN G+ L G S L C+P+GQW    P C  + C     +  +  N      
Sbjct: 2954 TYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCG----HPGVPPNAVLSGE 3009

Query: 723  NFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
             +++GS   + C   + L G +   CQ NGHWS + P C
Sbjct: 3010 KYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHC 3048



 Score =  196 bits (497), Expect = 1e-49
 Identities = 145/553 (26%), Positives = 228/553 (41%), Gaps = 42/553 (7%)

Query: 223  NSQCSFHCTDGYQVNGPSKLECLASGI----WTNKPPQCLAAQCPPLKIPERGNMTCLHS 278
            NS   + C  G+++ G S   C  S      W    P C A  C   K P  G +     
Sbjct: 2589 NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTD- 2647

Query: 279  AKAFQHQSSCSFSCEEGFALVGPEVVQ--CTASGVWTA--PAPVCKAVQCQHLEA--PSE 332
               +   +  ++ C +G+ L   E+    C + G W+     P C  V C  + +     
Sbjct: 2648 ---YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEH 2704

Query: 333  GTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWS--APLPTCEAISCEPLE 390
            G    V+  + + Y +   F C PGY   G   + C+ +G WS     P C+ ISC  L 
Sbjct: 2705 GRWRIVNG-SHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELP 2763

Query: 391  SPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQD 450
            +P +G+   + +     Y +   F C  GFML G+ +  C + G W+     C A  C  
Sbjct: 2764 TPPNGNKIGTQT----SYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCG- 2818

Query: 451  LPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPC 510
              +P E  VN       + Y+    + CN G  L+G+SV  C    NW+   P C  + C
Sbjct: 2819 --IP-ELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSC 2875

Query: 511  TPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAI 570
                SP  G  +        ++     F C+ GY + GP +  C  + +W+  PPMC+ +
Sbjct: 2876 GHPGSPIYGRTSG----NGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVV 2931

Query: 571  KCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCK 630
             C +   P     +     G F  G+   + C+ G+ L G + + C  +G+W    P C 
Sbjct: 2932 NCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2991

Query: 631  GIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSG 690
             I     PGV   A+ +   G  Y      TFG  +T ++ C    +L+G S+ +C+ +G
Sbjct: 2992 MI-DCGHPGVPPNAVLS---GEKY------TFG--STVHYSCTGKRSLLGQSSRTCQLNG 3039

Query: 691  QWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQE 750
             W+   P C          +     + S    NF   S   + C  G +L+GS +  C  
Sbjct: 3040 HWSGSQPHCSGDATGTCG-DPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLA 3098

Query: 751  NGHWSTTVPTCQA 763
            NG W+   P C+A
Sbjct: 3099 NGSWTGRQPECKA 3111



 Score =  163 bits (413), Expect = 5e-40
 Identities = 111/384 (28%), Positives = 165/384 (42%), Gaps = 28/384 (7%)

Query: 192  PECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWT 251
            PEC+ V +CG    P          +   +F+S   + C +GY ++GPS  +C A+G W+
Sbjct: 3107 PECKAV-QCGN---PGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWS 3162

Query: 252  NKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFA--LVGPEVVQCTAS 309
               P C    C    IP  G    L     +    + S+ C+ G+   L G  +  CT +
Sbjct: 3163 GTLPNCTIISCGDPGIPANG----LRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTIN 3218

Query: 310  GVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCI 369
            G W+   P C+AV C      S G ++     T F +G S  + C PGY +    +L C+
Sbjct: 3219 GTWSGVMPTCRAVTCPTPPQISNGRLEG----TNFDWGFSISYICSPGYELSFPAVLTCV 3274

Query: 370  DSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVR 429
             +G WS  +P C    C     P  G  +     ++F Y +  SF C   F+L G+    
Sbjct: 3275 GNGTWSGEVPQCLPKFCGDPGIPAQGKREG----KSFIYQSEVSFSCNFPFILVGSSTRI 3330

Query: 430  CDNLGQWTAPAPVC---QALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVG 486
            C   G W+  +P C       C++  VP     N  + FG F+  SV  F C +G LL G
Sbjct: 3331 CQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQN--NTFG-FQVGSVVQFHCKKGHLLQG 3387

Query: 487  ASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSL 546
            ++   CL    W+ + PEC    C     P+      V  +   S+  T  + C  G+ L
Sbjct: 3388 STTRTCLPDLTWSGIQPECIPHSCK---QPETPAHANVVGMDLPSHGYTLIYTCQPGFFL 3444

Query: 547  S-GPERLDCTRSGRWTDSPPMCEA 569
            + G E   C     WT   P+CEA
Sbjct: 3445 AGGTEHRVCRSDNTWTGKVPICEA 3468



 Score =  151 bits (381), Expect = 3e-36
 Identities = 116/394 (29%), Positives = 161/394 (40%), Gaps = 44/394 (11%)

Query: 383  AISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ----WTA 438
            A  C   ESP HG +    S    Q ++   + C  GF L G     C         W A
Sbjct: 2566 AFYCSTPESPPHGYII---SQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDA 2622

Query: 439  PAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQ--CLATG 496
            P P CQA+ C     P    +  +      R     ++ CN+G  L    +    C + G
Sbjct: 2623 PVPACQAISCGIPKAPTNGGILTTDYLVGTRV----TYFCNDGYRLSSKELTTAVCQSDG 2678

Query: 497  NWNS--VPPECQAIPCTPLLS--PQNGTMTCVQPLGSS-SYKSTCQFICDEGYSLSGPER 551
             W++    P C  + C  + S   ++G    V   GS   YK+   F CD GY   GP  
Sbjct: 2679 TWSNHNKTPRCVVVTCPSINSFILEHGRWRIVN--GSHYEYKTKVVFSCDPGYHGLGPAS 2736

Query: 552  LDCTRSGRWT--DSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLE 609
            ++C  +G W+  +  P C+ I C EL  P  G+   + T    + GST  F+CD GF L 
Sbjct: 2737 IECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQT----SYGSTAIFTCDLGFMLV 2792

Query: 610  GPNNVECTTSGRWSATPPTC-KGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTC 668
            G    EC +SG WS +   C  G   +P        L   GQ           +G+  T 
Sbjct: 2793 GSAVRECLSSGLWSESETRCLAGHCGIPE-------LIVNGQVI------GENYGYRDTV 2839

Query: 669  YFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGS 728
             + CN GF LIG S   C+    W+   P+C  V C   H   PI    S     F++  
Sbjct: 2840 VYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCG--HPGSPIYGRTSG--NGFNFND 2895

Query: 729  ICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762
            + +F C  G L+ G  +  CQ N  WS   P C+
Sbjct: 2896 VVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCK 2929



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 75/278 (26%), Positives = 119/278 (42%), Gaps = 32/278 (11%)

Query: 507  AIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSG----RWTD 562
            A  C+   SP +G +  +   G     S  ++ CD G+ L G     C +S      W  
Sbjct: 2566 AFYCSTPESPPHGYI--ISQTGGQ-LNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDA 2622

Query: 563  SPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPN--NVECTTSG 620
              P C+AI C    AP  G +  +D    + VG+   + C++G++L         C + G
Sbjct: 2623 PVPACQAISCGIPKAPTNGGILTTD----YLVGTRVTYFCNDGYRLSSKELTTAVCQSDG 2678

Query: 621  RWSATPPTCKGIASLPTPGVQCPALTT----PGQGTMYCRHHPGTFGFNTTCYFGCNAGF 676
             WS    T + +       V CP++ +     G+  +    H   + + T   F C+ G+
Sbjct: 2679 TWSNHNKTPRCVV------VTCPSINSFILEHGRWRIVNGSH---YEYKTKVVFSCDPGY 2729

Query: 677  TLIGDSTLSCRPSGQWT--AVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHC 734
              +G +++ C P+G W+     P C+ + C EL    P   N + +    SYGS   F C
Sbjct: 2730 HGLGPASIECLPNGTWSWRNERPYCQIISCGEL----PTPPNGNKIGTQTSYGSTAIFTC 2785

Query: 735  LEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEAL 772
              G +L GSA   C  +G WS +   C AG   I E +
Sbjct: 2786 DLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELI 2823



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 62/245 (25%), Positives = 91/245 (37%), Gaps = 64/245 (26%)

Query: 219  NFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHS 278
            NF +    S+ C+ GY+++ P+ L C+ +G W+ + PQCL   C    IP +G       
Sbjct: 3248 NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGK----RE 3303

Query: 279  AKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVC---KAVQCQHLEAPSEG-- 333
             K+F +QS  SFSC   F LVG     C A G W+  +P C       C++   P  G  
Sbjct: 3304 GKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQ 3363

Query: 334  --------------------------TMDCVHPLTAF----------------------- 344
                                      T  C+  LT                         
Sbjct: 3364 NNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVV 3423

Query: 345  -----AYGSSCKFECQPGYRVRGLDMLR-CIDSGHWSAPLPTCEAISCEPLESPVHGSMD 398
                 ++G +  + CQPG+ + G    R C     W+  +P CEA S   ++ P      
Sbjct: 3424 GMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGT 3483

Query: 399  CSPSL 403
             SP L
Sbjct: 3484 PSPKL 3488



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 111/485 (22%), Positives = 171/485 (35%), Gaps = 123/485 (25%)

Query: 261  QCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALV-GPEVVQCTASG---VWTAPA 316
            +CP   IP    +        FQ  SS S  CEEGF    G E + C       +W+   
Sbjct: 833  ECPDPGIP----INARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLI 888

Query: 317  PVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKF--ECQPGYRVR----------GLD 364
            P C A    H  APS   +    P   +    +C++  E +PG+ ++            D
Sbjct: 889  PKCGAPCGGHFSAPSGVILSPGWP-GYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYD 947

Query: 365  MLRCIDSGHWSAPL-----------------------------------------PTCEA 383
            +L   D  +  +PL                                          T   
Sbjct: 948  VLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNT 1007

Query: 384  ISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC 443
             SC     PVHG          F   +  SF C  G+ L   + + C+    W+ P P C
Sbjct: 1008 YSCLDPGIPVHGRRYGHD----FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1063

Query: 444  QALQCQDLPVPNEARVNCSHPFGAFRYQSV-CSFTCNEGLLLVGASVLQCLATGNWNSVP 502
             AL   D+  P+   ++  +P   F   S+ C++T +   +  G  V       N+++  
Sbjct: 1064 DALCGGDVRGPSGTILSPGYP--EFYPNSLNCTWTVD---VTHGKGV-----QFNFHTFH 1113

Query: 503  PECQAIPCTPLLSPQNGTMTCVQPLGS---------------SSYKSTCQFICDEGYSLS 547
             E        LL  +NG+ T  QPL                  ++++  +FI D   S  
Sbjct: 1114 LEDHH---DYLLITENGSFT--QPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYE 1168

Query: 548  GPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFK 607
            G    + T S  +   P       C +   P+ GS         F +G T  FSC +G++
Sbjct: 1169 G---FNITFS-EYNLEP-------CEDPGIPQYGSR----IGFNFGIGDTLTFSCSSGYR 1213

Query: 608  LEGPNNVECTTSGR--WSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFN 665
            LEG + + C   GR  WSA  P C           +C A  T  +G +   ++P  +  N
Sbjct: 1214 LEGTSEIICLGGGRRVWSAPLPRCV---------AECGASATNNEGILLSPNYPLNYENN 1264

Query: 666  TTCYF 670
              C +
Sbjct: 1265 HECIY 1269



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 106/456 (23%), Positives = 169/456 (37%), Gaps = 87/456 (19%)

Query: 175  LETIGNYTCSCYPGFYGPECEYVRE-CGELELPQHVLMNCSHPLG-NFSFNSQCSFHCTD 232
            L  I +++ S Y GF     EY  E C +  +PQ+        +G NF      +F C+ 
Sbjct: 1157 LRFISDFSIS-YEGFNITFSEYNLEPCEDPGIPQY-----GSRIGFNFGIGDTLTFSCSS 1210

Query: 233  GYQVNGPSKLECLASG--IWTNKPPQCLAAQC-------------PPLKIPERGNMTCLH 277
            GY++ G S++ CL  G  +W+   P+C+A +C             P   +    N  C++
Sbjct: 1211 GYRLEGTSEIICLGGGRRVWSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENNHECIY 1269

Query: 278  SAKAFQHQ----SSCSFSCEEGFALVGPEVVQCTAS--GVWTAPAPVCKAVQCQ------ 325
            S +    +    S+ +F   +G  L   +    T    G +T  +     +         
Sbjct: 1270 SIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWL 1329

Query: 326  HLEAPSEGTMD-------------CVHP-LTAFAY---------GSSCKFECQPGYRVRG 362
               + +EGT +             C  P +  F Y         GS+  + C PGY + G
Sbjct: 1330 EFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHG 1389

Query: 363  LDMLRCI--DSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGF 420
              +L+C+  +   W  PLP+C A      +    G +  SP    F YD N   RC    
Sbjct: 1390 SSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRI-LSPGY-PFPYDNN--LRCMWMI 1445

Query: 421  MLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARV----NCSHPFGAFRYQSVCSF 476
             +   +IV    L   T  +     L+  D P  N+  +        P G     ++ + 
Sbjct: 1446 EVDPGNIVSLQFLAFDTEASH--DILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTI 1503

Query: 477  TCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTC 536
              +    +  +      A    +SV   C+  P  P+   +NG               T 
Sbjct: 1504 QFDTDFYISKSG----FAIQFSSSVATACRD-PGVPMNGTRNG--------DGREPGDTV 1550

Query: 537  QFICDEGYSLSGPERLDCTRSGR---WTDSPPMCEA 569
             F CD GY L G ER+ C +      W  SPP+C A
Sbjct: 1551 VFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA 1586



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 110/515 (21%), Positives = 174/515 (33%), Gaps = 85/515 (16%)

Query: 186  YPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECL 245
            Y GF+    EY  +  E       +MN +    ++   S  +++C  GY + G S L C+
Sbjct: 1686 YTGFH---LEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCI 1742

Query: 246  ASGI----WTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCE--EGFALV 299
                    W    P C  A C        G +   +  K +    +C +S    + F + 
Sbjct: 1743 MGDDGRPGWNRALPSC-HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVF 1801

Query: 300  GPEVVQCTA--SGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPG 357
            G  V   T+    V     P  ++     L     G      PL++     + +F     
Sbjct: 1802 GQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGES---LPLSS-GNQITIRFTSVGP 1857

Query: 358  YRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCA 417
               +G   +           +P   +  C  +  P  G    +     F   ++  F C 
Sbjct: 1858 ITAKGFHFVY--------QAVPRTSSTQCSSVPEPRFGRRIGNE----FAVGSSVLFDCN 1905

Query: 418  EGFMLRGADIVRCD----NLGQWTAPAPVCQALQCQDL-------------PVPNEARVN 460
             G++L G+  +RC+    +L QW    P C  + C  +             P P +  +N
Sbjct: 1906 PGYILHGSIAIRCETVPNSLAQWNDSLPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLN 1964

Query: 461  CSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGT 520
            C           V   T  EG   +   V+      NW+S+          P L   +GT
Sbjct: 1965 C-----------VWKITVPEGAG-IQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGT 2012

Query: 521  MTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQ 580
             T    L S+S      F  D   S +G   L+ T  G   DS        CPE   P  
Sbjct: 2013 -TIPHLLNSTSNNLYLNFQSDISVSAAG-FHLEYTAIG--LDS--------CPEPQTPSS 2060

Query: 581  GSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTS--GRWSATPPTCKGIASLPTP 638
            G +   D    + VG    F CD G+ L+G +++ C      RW+   P C         
Sbjct: 2061 G-IKIGD---RYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICL-------- 2108

Query: 639  GVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCN 673
              QC    +   G +     PG +  +  C +  N
Sbjct: 2109 -AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTIN 2142



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 121/600 (20%), Positives = 189/600 (31%), Gaps = 168/600 (28%)

Query: 228  FHCTDGYQVNGPSKLECLASG---IWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQH 284
            F C  GY++ G  ++ C+       W   PP C+A  C        G +   +    + H
Sbjct: 1552 FQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAP-CGGNLTGSSGFILSPNFPHPYPH 1610

Query: 285  QSSC-----------------SFSCEEGFALV----GPEVVQCTASGVWTAPAP--VCKA 321
               C                 SFS E  +  +    GP+           +  P  +  +
Sbjct: 1611 SRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESS 1670

Query: 322  VQCQHLEAPSEGTMD---------------CVHPLTA---------FAYGSSCKFECQPG 357
                HL   S+G++                C  P            +  GS+  + C  G
Sbjct: 1671 SNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAG 1730

Query: 358  YRVRGLDMLRCI--DSGH--WSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCS 413
            Y ++G   L CI  D G   W+  LP+C A  C    +   G++      + +    NC 
Sbjct: 1731 YVLQGYSTLTCIMGDDGRPGWNRALPSCHA-PCGSRSTGSEGTVLSPNYPKNYSVGHNCV 1789

Query: 414  FRCA--EGFMLRGADI-------------------------------------------- 427
            +  A  + F++ G  +                                            
Sbjct: 1790 YSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQIT 1849

Query: 428  VRCDNLGQWTAPA--------PVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCN 479
            +R  ++G  TA          P   + QC  +P P   R         F   S   F CN
Sbjct: 1850 IRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGR----RIGNEFAVGSSVLFDCN 1905

Query: 480  EGLLLVGASVLQCLATGN----WNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKST 535
             G +L G+  ++C    N    WN   P C  +PC  +L+ + GT               
Sbjct: 1906 PGYILHGSIAIRCETVPNSLAQWNDSLPTC-IVPCGGILTKRKGT--------------- 1949

Query: 536  CQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPEL-FAPEQG--SLDCSD----- 587
               I   GY       L+C     W  + P    I+   + FA E    SLD  D     
Sbjct: 1950 ---ILSPGYPEPYDNNLNCV----WKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNN 2002

Query: 588  --TRGEFNVGSTCHF--SCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCP 643
                G ++  +  H   S  N   L   +++  + +G       T  G+ S P P     
Sbjct: 2003 APRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAG--FHLEYTAIGLDSCPEP----- 2055

Query: 644  ALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPS--GQWTAVTPACRA 701
               TP  G          +       F C+ G++L G S ++C P    +W    P C A
Sbjct: 2056 --QTPSSGIKI----GDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLA 2109



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 91/450 (20%), Positives = 161/450 (35%), Gaps = 80/450 (17%)

Query: 276  LHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTM 335
            +     F ++    F C+ GF L+G + + C  +  W+A  P+C      +  AP    +
Sbjct: 674  IREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVL 733

Query: 336  DCVHPLTAFAYGSSCKFEC--QPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPV 393
               +P   +    +C +     PG R+         +     +          +  ESP+
Sbjct: 734  SPDYP-EGYGNNLNCIWTIISDPGSRIH-----LSFNDFDLESQFDFLAVKDGDSPESPI 787

Query: 394  HGSM---DCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQD 450
             G+    +    L +  +     F+       RG +I   +  G            +C D
Sbjct: 788  LGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITY-NTFGH----------NECPD 836

Query: 451  LPVPNEARVNCSHPFGA-FRYQSVCSFTCNEGLLLV-GASVLQCLATGN---WNSVPPEC 505
              +P  AR      FG  F+  S  S  C EG +   G   + C+       W+ + P+C
Sbjct: 837  PGIPINAR-----RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 891

Query: 506  QAIPCTPLLSPQNGTMTCVQPLGSSSYKST--CQFI--CDEGYSLSGP-ERLDCTRSGRW 560
             A PC    S  +G +  + P     YK +  C+++   + G+S+    ER     +   
Sbjct: 892  GA-PCGGHFSAPSGVI--LSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNY-- 946

Query: 561  TDSPPMCEAIKCPELFAPEQGSLD--------CSDTRGEFNVGSTCHFSCDNGFKLEGPN 612
                 + E    P L +P  GS +         S +   + + +T +   +NGFK+    
Sbjct: 947  ----DVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKI---- 998

Query: 613  NVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGC 672
            + E  T   +S   P       +P  G                R +   F   +T  F C
Sbjct: 999  HYESVTVNTYSCLDP------GIPVHG----------------RRYGHDFSIGSTVSFSC 1036

Query: 673  NAGFTLIGDSTLSCRPSGQWTAVTPACRAV 702
            ++G+ L  +  L C  +  W+   P C A+
Sbjct: 1037 DSGYRLSHEEPLLCEKNHWWSHPLPTCDAL 1066



 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 96/440 (21%), Positives = 160/440 (36%), Gaps = 73/440 (16%)

Query: 282  FQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHP- 340
            F   S+ SFSC+ G+ L   E + C  +  W+ P P C A+    +  PS   +   +P 
Sbjct: 1026 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPE 1085

Query: 341  ----------LTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEP-L 389
                           +G   +F     +     D L   ++G ++ PL         P +
Sbjct: 1086 FYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTI 1145

Query: 390  ESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQ 449
             + ++G+      LR F  D + S+   EGF +  ++     NL              C+
Sbjct: 1146 NAGLYGNFRAQ--LR-FISDFSISY---EGFNITFSEY----NLEP------------CE 1183

Query: 450  DLPVPNE-ARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGN--WNSVPPECQ 506
            D  +P   +R+  +   G        +F+C+ G  L G S + CL  G   W++  P C 
Sbjct: 1184 DPGIPQYGSRIGFNFGIG-----DTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1238

Query: 507  AIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPM 566
            A  C    +   G +  + P    +Y++  + I    YS+         ++G+  +    
Sbjct: 1239 A-ECGASATNNEGIL--LSPNYPLNYENNHECI----YSIQ-------VQAGKGINISAR 1284

Query: 567  CEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHF---SCDNGFKLEGPNNVECTTSGRWS 623
               +   ++     G    +   G F   S       S  N   LE  ++ E T  G   
Sbjct: 1285 TFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQL 1344

Query: 624  ATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDST 683
                T   ++    PG+         QG     H  G+     T  +GCN G+TL G S 
Sbjct: 1345 VY--TSFELSHCEDPGIPQFGYKISDQG-----HFAGS-----TIIYGCNPGYTLHGSSL 1392

Query: 684  LSCRPSGQ--WTAVTPACRA 701
            L C    +  W    P+C A
Sbjct: 1393 LKCMTGERRAWDYPLPSCIA 1412



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 100/445 (22%), Positives = 153/445 (34%), Gaps = 86/445 (19%)

Query: 347  GSSCKFECQPGYRVRGLDMLRCIDSGH---WSAPLPTCEA------------ISCEPLES 391
            G +  F+C PGY ++G + + CI   +   W    P C A            I       
Sbjct: 1547 GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPH 1606

Query: 392  PVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAP---APVCQALQC 448
            P   S DC  ++       N  +  +  F+    +    D L  +  P   +P+  + Q 
Sbjct: 1607 PYPHSRDCDWTITV-----NADYVISLAFISFSIE-PNYDFLYIYDGPDSNSPLIGSFQD 1660

Query: 449  QDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQ--CLATGNWNSVPPECQ 506
              LP   E+  N  H   AFR     S+T   G  L   + L+  C   GN         
Sbjct: 1661 SKLPERIESSSNTMHL--AFRSDGSVSYT---GFHLEYKAKLRESCFDPGNI-------- 1707

Query: 507  AIPCTPLLSPQNGTMTCVQPLGSSSYK--STCQFICDEGYSLSGPERLDCTRS--GR--W 560
                       NGT           YK  ST  + CD GY L G   L C     GR  W
Sbjct: 1708 ----------MNGTRL------GMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGW 1751

Query: 561  TDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSG 620
              + P C A  C       +G++   +    ++VG  C +S      +  P   E    G
Sbjct: 1752 NRALPSCHA-PCGSRSTGSEGTVLSPNYPKNYSVGHNCVYS------IAVPK--EFVVFG 1802

Query: 621  RWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIG 680
            ++     +   +  +     Q  +L +   G+      P + G   T  F      T  G
Sbjct: 1803 QFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKG 1862

Query: 681  DSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLL 740
               +       + AV P   + +CS +    P       +   F+ GS   F C  G +L
Sbjct: 1863 FHFV-------YQAV-PRTSSTQCSSV----PEPRFGRRIGNEFAVGSSVLFDCNPGYIL 1910

Query: 741  NGSAQTACQ----ENGHWSTTVPTC 761
            +GS    C+        W+ ++PTC
Sbjct: 1911 HGSIAIRCETVPNSLAQWNDSLPTC 1935



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 51/217 (23%), Positives = 80/217 (36%), Gaps = 46/217 (21%)

Query: 591  EFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQ 650
            +F++GST  FSCD+G++L     + C  +  WS   PTC  +      G     L+ PG 
Sbjct: 1025 DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILS-PGY 1083

Query: 651  GTMY-----------CRHHPGT-FGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTA--VT 696
               Y             H  G  F F+T  +   +  + LI ++    +P  + T   + 
Sbjct: 1084 PEFYPNSLNCTWTVDVTHGKGVQFNFHTF-HLEDHHDYLLITENGSFTQPLARLTGSDLP 1142

Query: 697  PACRA------------------------VKCSELHV----NKPIAMNCSNLWGNFSYGS 728
            P   A                        +  SE ++    +  I    S +  NF  G 
Sbjct: 1143 PTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGD 1202

Query: 729  ICSFHCLEGQLLNGSAQTACQENGH--WSTTVPTCQA 763
              +F C  G  L G+++  C   G   WS  +P C A
Sbjct: 1203 TLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA 1239



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 64/261 (24%), Positives = 98/261 (37%), Gaps = 47/261 (18%)

Query: 531  SYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPE----------- 579
            S  ST  F CD GY LS  E L C ++  W+   P C+A+   ++  P            
Sbjct: 1027 SIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEF 1086

Query: 580  -QGSLDCSDT------RG-EFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSAT--PPTC 629
               SL+C+ T      +G +FN   T H    + + L   N        R + +  PPT 
Sbjct: 1087 YPNSLNCTWTVDVTHGKGVQFNF-HTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTI 1145

Query: 630  K----GIASLPTPGVQCPALTTPGQGTMYCRHH------PG----------TFGFNTTCY 669
                 G        +   +++  G    +  ++      PG           FG   T  
Sbjct: 1146 NAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLT 1205

Query: 670  FGCNAGFTLIGDSTLSCRPSGQ--WTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYG 727
            F C++G+ L G S + C   G+  W+A  P C A +C     N    +   N   N+   
Sbjct: 1206 FSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENN 1264

Query: 728  SIC--SFHCLEGQLLNGSAQT 746
              C  S     G+ +N SA+T
Sbjct: 1265 HECIYSIQVQAGKGINISART 1285



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 53/240 (22%), Positives = 74/240 (30%), Gaps = 66/240 (27%)

Query: 262 CPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQC----TASGVWTAPAP 317
           CP    PE G          F   S+  FSC+E + L G + + C         W+   P
Sbjct: 486 CPDPGEPENGKRI----GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRP 541

Query: 318 VCKAVQC-QHLEAPS------------EGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLD 364
           VCK   C  +L+ PS            +    CV  +TA       +   +      G D
Sbjct: 542 VCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYD 601

Query: 365 MLRCIDSGHWSAP--------------------------LPTCEAI-------------- 384
            L   D G    P                          L T E++              
Sbjct: 602 TLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEK 661

Query: 385 -SCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC 443
            SC    +P++G  +       F       F C  GF L G   + C    QW+A  P+C
Sbjct: 662 ESCGDPGTPLYGIREGD----GFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 717



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 23/63 (36%), Positives = 30/63 (47%), Gaps = 8/63 (12%)

Query: 572 CPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVEC----TTSGRWSATPP 627
           CP+   PE G    SD    F++GST  FSCD  + L+G  ++ C         WS   P
Sbjct: 486 CPDPGEPENGKRIGSD----FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRP 541

Query: 628 TCK 630
            CK
Sbjct: 542 VCK 544



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 64/265 (24%), Positives = 95/265 (35%), Gaps = 28/265 (10%)

Query: 442  VCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCL--ATGNWN 499
            V QA Q Q  P P   R N       F      SF C  G  L+G S L CL   + NWN
Sbjct: 2215 VYQAYQLQSCPDPRPFR-NGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWN 2273

Query: 500  SVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR 559
               P C+A+ C   ++  NGT      + S  Y        D  + +  P       +  
Sbjct: 2274 HPLPRCEAL-CGGNITAMNGT------IYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFT 2326

Query: 560  WTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTS 619
               + P+ + I   +   P+Q S       G  N      +S  N   ++   + + TTS
Sbjct: 2327 VLQTEPIYDFITVWD--GPDQNSPQIGQFSG--NTALESVYSTSNQILIK--FHSDFTTS 2380

Query: 620  GRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLI 679
            G +  +    +     P P V    + T              F       + C  GFTL+
Sbjct: 2381 GFFVLSYHAYQLRVCQPPPPVPNAEILT----------EDDEFEIGDIIRYQCLPGFTLV 2430

Query: 680  GDSTLSCRPSG--QWTAVTPACRAV 702
            G++ L+CR     Q     P C+ +
Sbjct: 2431 GNAILTCRLGERLQMDGAPPVCQVL 2455



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 19/43 (44%), Positives = 25/43 (58%), Gaps = 2/43 (4%)

Query: 344  FAYGSSCKFECQPGYRVRGLDMLRCID--SGHWSAPLPTCEAI 384
            F  G +  FEC PGY + G   L C+   S +W+ PLP CEA+
Sbjct: 2240 FTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL 2282



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 25/88 (28%), Positives = 39/88 (44%), Gaps = 10/88 (11%)

Query: 516 PQNGTMTCVQPLGSS-SYKSTCQFICDEGYSLSGPERLDCTRSGR----WTDSPPMCEAI 570
           P+NG     + +GS  S  ST QF CDE Y L G + + C R       W+D  P+C+  
Sbjct: 492 PENG-----KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVK 546

Query: 571 KCPELFAPEQGSLDCSDTRGEFNVGSTC 598
            C        G+    +   +++  + C
Sbjct: 547 TCGSNLQGPSGTFTSPNFPFQYDSNAQC 574



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 101/443 (22%), Positives = 154/443 (34%), Gaps = 89/443 (20%)

Query: 219  NFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHS 278
            +FS  S  SF C  GY+++    L C  +  W++  P C A     ++ P    ++    
Sbjct: 1025 DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILS---- 1080

Query: 279  AKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQ----HLEAPSEGT 334
                            G+    P  + CT    WT      K VQ      HLE      
Sbjct: 1081 ---------------PGYPEFYPNSLNCT----WTVDVTHGKGVQFNFHTFHLE------ 1115

Query: 335  MDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDS---GHWSAPLP------------ 379
             D    L     GS      QP  R+ G D+   I++   G++ A L             
Sbjct: 1116 -DHHDYLLITENGSF----TQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGF 1170

Query: 380  --TCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ-- 435
              T    + EP E P             F      +F C+ G+ L G   + C   G+  
Sbjct: 1171 NITFSEYNLEPCEDPGIPQYGSRIGFN-FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRV 1229

Query: 436  WTAPAPVCQALQCQDLPVPNEA-RVNCSHPFG-AFRYQSVCSFTCNEGLLLVGASVLQCL 493
            W+AP P C A +C      NE   ++ ++P      ++ + S     G  +  ++    L
Sbjct: 1230 WSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL 1288

Query: 494  ATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFI-----CDEGYSLSG 548
            A G+   +         T LL    G       L S+S +   +F       DEG+ L  
Sbjct: 1289 AQGDVLKIYDGKD--KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVY 1346

Query: 549  PERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKL 608
                               E   C +   P+ G    SD +G F  GST  + C+ G+ L
Sbjct: 1347 TS----------------FELSHCEDPGIPQFG-YKISD-QGHF-AGSTIIYGCNPGYTL 1387

Query: 609  EGPNNVECTTSGR--WSATPPTC 629
             G + ++C T  R  W    P+C
Sbjct: 1388 HGSSLLKCMTGERRAWDYPLPSC 1410



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 46/241 (19%), Positives = 75/241 (31%), Gaps = 73/241 (30%)

Query: 406 FQYDTNCSFRCAEGFMLRGADIVRCDNLGQ----WTAPAPVCQALQC------------- 448
           F   +   F C E ++L+GA  + C  + +    W+   PVC+   C             
Sbjct: 502 FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTS 561

Query: 449 QDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVG---------------ASVLQCL 493
            + P   ++   C     A     V      E  L +G                +VLQ L
Sbjct: 562 PNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVL 621

Query: 494 ATG-------------------------------NWNSVPPECQAIPCTPLLSPQNGTMT 522
            TG                               N+  +  E    P TPL   + G   
Sbjct: 622 -TGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREG--- 677

Query: 523 CVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGS 582
                   S +   +F C  G+ L G + + C  + +W+ + P+C    C   F    G+
Sbjct: 678 -----DGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC-IFPCLSNFTAPMGT 731

Query: 583 L 583
           +
Sbjct: 732 V 732



 Score = 35.4 bits (80), Expect = 0.22
 Identities = 15/38 (39%), Positives = 17/38 (44%)

Query: 724 FSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
           FS   +  F C  G  L G     CQEN  WS  +P C
Sbjct: 680 FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 717



 Score = 35.0 bits (79), Expect = 0.29
 Identities = 46/223 (20%), Positives = 73/223 (32%), Gaps = 63/223 (28%)

Query: 595  GSTCHFSCDNGFKLEGPNNVECTTSGR---WSATPPTCKGIASLPTPGVQCPALTTPGQG 651
            G T  F CD G++L+G   + C        W  +PP C            C    T   G
Sbjct: 1547 GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI---------APCGGNLTGSSG 1597

Query: 652  TMYCRHHPGTFGFNTTC------------------------------YFGCNAGFTLIG- 680
             +   + P  +  +  C                              Y G ++   LIG 
Sbjct: 1598 FILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGS 1657

Query: 681  --DSTLSCRPSGQWTAVTPACRA--------------VKCSELHVNKPIAMNCSNLWGNF 724
              DS L  R       +  A R+               K  E   +    MN + L  ++
Sbjct: 1658 FQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDY 1717

Query: 725  SYGSICSFHCLEGQLLNGSAQTAC--QENGH--WSTTVPTCQA 763
              GS  +++C  G +L G +   C   ++G   W+  +P+C A
Sbjct: 1718 KLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA 1760



 Score = 34.7 bits (78), Expect = 0.37
 Identities = 23/87 (26%), Positives = 34/87 (39%), Gaps = 18/87 (20%)

Query: 342 TAFAYGSSCKFECQPGYRVRGLDMLRCI----DSGHWSAPLPTCEA-------------- 383
           T F  G   ++ C  GY + G   L CI    ++  W  P+P C A              
Sbjct: 192 TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGI 251

Query: 384 ISCEPLESPVHGSMDCSPSLRAFQYDT 410
           IS     +  H + DC+ ++ A   DT
Sbjct: 252 ISSPSFPNEYHNNADCTWTIVAEPGDT 278



 Score = 30.4 bits (67), Expect = 7.0
 Identities = 18/46 (39%), Positives = 23/46 (50%), Gaps = 3/46 (6%)

Query: 217  LGN-FSFNSQCSFHCTDGYQVNGPSKLECL--ASGIWTNKPPQCLA 259
            +GN F+     SF C  GY + G S L CL   S  W +  P+C A
Sbjct: 2236 IGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEA 2281



 Score = 30.0 bits (66), Expect = 9.2
 Identities = 16/51 (31%), Positives = 21/51 (41%), Gaps = 4/51 (7%)

Query: 716 NCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGH----WSTTVPTCQ 762
           N   +  +FS GS   F C E  +L G+    CQ        WS   P C+
Sbjct: 494 NGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 544


>gi|148886654 polydom [Homo sapiens]
          Length = 3571

 Score =  255 bits (652), Expect = 1e-67
 Identities = 165/599 (27%), Positives = 267/599 (44%), Gaps = 53/599 (8%)

Query: 168  CSKQGECLETIGNYTCSCYPGFYGP--ECEYVRECGELELPQHVLMNCSHPLGN-FSFNS 224
            CS+   CL   G+Y CSC P + G    C    +C     P++      H  G  ++  +
Sbjct: 1755 CSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPEN-----GHSSGEIYTVGA 1809

Query: 225  QCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQH 284
            + +F C +GYQ+ G +K+ CL SG W +  P C A  C    IPE G   C+    AF  
Sbjct: 1810 EVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENG---CIEEL-AFTF 1865

Query: 285  QSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAF 344
             S  ++ C +G+ L G +   C A+  W+   PVC+ V+C   E  + G     + L+  
Sbjct: 1866 GSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGK----YILSGL 1921

Query: 345  AYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLR 404
             Y S+  + C  GY ++G  ++ C  SG W    P C  + C   E P     D   +  
Sbjct: 1922 TYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCG--EPP--AIKDAVITGN 1977

Query: 405  AFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHP 464
             F +    ++ C EG+ L G D + C   G+W+     C A+ C + P+ + A    +H 
Sbjct: 1978 NFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHR 2037

Query: 465  FGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIP-CTPLL--SPQNGTM 521
                 +  +  + C++G  L   S L C A G W  VPPE Q +P C       P + + 
Sbjct: 2038 L----FGDIAFYYCSDGYSLADNSQLLCNAQGKW--VPPEGQDMPRCIAHFCEKPPSVSY 2091

Query: 522  TCVQPLGSSSYK--STCQFICDEGYSLSGPERLDCTRSGRWTDSPP--MCEAIKCPELFA 577
            + ++ +  + +   S   F C EG+ L+   +++C R G+W  SP    C  ++C E  +
Sbjct: 2092 SILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPS 2151

Query: 578  PEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPT 637
               G    S+    ++ G+   +SC+ GF ++G     C  +G+WS+  PTC  ++    
Sbjct: 2152 IMNGYASGSN----YSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEP 2207

Query: 638  PGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTP 697
            P V+            +  H  G   F +   + CN G+  +G     C+ +  W + +P
Sbjct: 2208 PKVE----------NGFLEHTTGRI-FESEVRYQCNPGYKSVGSPVFVCQANRHWHSESP 2256

Query: 698  ACRAVKCSELHVNKPIAMNCSNLWG-NFSYGSICSFHCLEGQLLNGSAQTACQENGHWS 755
                + C  L   KP  +    + G NF  GS   F C EG  L G +   CQ++G W+
Sbjct: 2257 ----LMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWN 2311



 Score =  239 bits (611), Expect = 6e-63
 Identities = 168/678 (24%), Positives = 271/678 (39%), Gaps = 104/678 (15%)

Query: 150  CLKKKHALCYTASCQDMSCSKQGECLETIGNYT---------CSCYPGFY--GPECEYVR 198
            C +  H L    +C+ + C K  E L    +YT          SC  GF   GP      
Sbjct: 2480 CGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCL 2539

Query: 199  ECGE--LELPQHVLMNCSHPL---------GNFSFNSQCSFHCTDGYQVNGPSKLECLAS 247
            E G+  ++ P    ++C  P           ++S+ +   + C  G+QV G +   C  S
Sbjct: 2540 ETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEES 2599

Query: 248  GIWTNKPPQCLAAQC--PP-----------------------LKIP-------------- 268
            G W++  P C+   C  PP                       +++P              
Sbjct: 2600 G-WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVA 2658

Query: 269  ----ERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQC 324
                        HS+  F + +  S++C  G+ L+G  V+ C   G W   AP C +++C
Sbjct: 2659 KTWENTKESPATHSSN-FLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIEC 2717

Query: 325  QHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAI 384
                AP  G +      T  + GS+ ++ C+PG+ + G D+  C+++  WS   P CEAI
Sbjct: 2718 DLPTAPENGFLR----FTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAI 2773

Query: 385  SCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQ 444
            SC+     ++GS+  S     + Y +   + C  G++L G +   C +   W    P+C 
Sbjct: 2774 SCKKPNPVMNGSIKGS----NYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICI 2829

Query: 445  ALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPE 504
             + C   PV    +V        + +Q    +TCNEG LL GA    CLA G+W+   P+
Sbjct: 2830 PVDCSSPPVSANGQVRGDE----YTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPD 2885

Query: 505  CQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSP 564
            C  + C       NG    +       +     F C EGY L G  +L C   G W    
Sbjct: 2886 CVPVRCATPPQLANGVTEGL----DYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEI 2941

Query: 565  PMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSA 624
            P+C+ + C     P +           F  G    + C  G+KL G ++  C ++G WS 
Sbjct: 2942 PLCKPVNC----GPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSG 2997

Query: 625  TPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTL 684
            + P+C       TP ++            Y   +   F         C  GF L+G S +
Sbjct: 2998 SSPSCLP-CRCSTPVIE------------YGTVNGTDFDCGKAARIQCFKGFKLLGLSEI 3044

Query: 685  SCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSA 744
            +C   GQW++  P C    C  L +     ++ ++ W      ++ ++ C  G ++ GS+
Sbjct: 3045 TCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKE----NVITYSCRSGYVIQGSS 3100

Query: 745  QTACQENGHWSTTVPTCQ 762
               C E G WS   P C+
Sbjct: 3101 DLICTEKGVWSQPYPVCE 3118



 Score =  235 bits (600), Expect = 1e-61
 Identities = 188/677 (27%), Positives = 282/677 (41%), Gaps = 66/677 (9%)

Query: 98   NKTWTWVGTKKALTNEAENWADNEPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHAL 157
            NK +T  G K++      +W+ + P        C  +   SP      N ++ L     L
Sbjct: 1874 NKGYTLAGDKESSCLANSSWSHSPPV-------CEPVKCSSPENIN--NGKYILSGLTYL 1924

Query: 158  CYTASCQDMSCSKQGECLETIGNYTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPL 217
               +   D   S QG    +I   T S       P C  V  CGE    +  ++  +   
Sbjct: 1925 STASYSCDTGYSLQGP---SIIECTASGIWDRAPPACHLVF-CGEPPAIKDAVITGN--- 1977

Query: 218  GNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLH 277
             NF+F +  ++ C +GY + G   +ECLA G W+    QCLA  C    I +  +    H
Sbjct: 1978 -NFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAH 2036

Query: 278  SAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPA----PVCKAVQCQHLEAPSEG 333
                        + C +G++L     + C A G W  P     P C A  C+   + S  
Sbjct: 2037 RLFG----DIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYS 2092

Query: 334  TMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPV 393
             ++ V     FA GS   F+C  G+ +     + C+  G W+   P+  +I C P+    
Sbjct: 2093 ILESVSK-AKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWN---PSPMSIQCIPVRCGE 2148

Query: 394  HGS-MDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLP 452
              S M+   S   + +    ++ C +GF ++G     C+  GQW++P P C  + C + P
Sbjct: 2149 PPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPP 2208

Query: 453  VPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPP-ECQAIPCT 511
                  +   H  G   ++S   + CN G   VG+ V  C A  +W+S  P  C  + C 
Sbjct: 2209 KVENGFLE--HTTGRI-FESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCG 2265

Query: 512  PLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTD-SPPMCEAI 570
                 QNG M       +    S  QF C+EGY L G     C +SG+W   S P C   
Sbjct: 2266 KPPPIQNGFMKGE----NFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPA 2321

Query: 571  KCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCK 630
            KCPE    E   L   +   E  V +   FSC  G  L+GP+ ++C  S +W+ + P CK
Sbjct: 2322 KCPEPPLLEN-QLVLKELTTEVGVVT---FSCKEGHVLQGPSVLKCLPSQQWNDSFPVCK 2377

Query: 631  GIASLPTP----GVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSC 686
             +   P P    GV  P+                   F +T  + C  GF L G+ST  C
Sbjct: 2378 IVLCTPPPLISFGVPIPS---------------SALHFGSTVKYSCVGGFFLRGNSTTLC 2422

Query: 687  RPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQT 746
            +P G W++  P C  V+C +    + I     ++ G  +Y S   + C  G  L G+  T
Sbjct: 2423 QPDGTWSSPLPECVPVECPQ---PEEIPNGIIDVQG-LAYLSTALYTCKPGFELVGNTTT 2478

Query: 747  ACQENGHWSTTVPTCQA 763
             C ENGHW    PTC+A
Sbjct: 2479 LCGENGHWLGGKPTCKA 2495



 Score =  233 bits (595), Expect = 4e-61
 Identities = 157/547 (28%), Positives = 243/547 (44%), Gaps = 45/547 (8%)

Query: 220  FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGN-MTCLHS 278
            F+  S  SF C +G+ +N  +K+EC+  G W   P   ++ QC P++  E  + M    S
Sbjct: 2102 FAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSP---MSIQCIPVRCGEPPSIMNGYAS 2158

Query: 279  AKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCV 338
               +   +  ++SC +GF + G +   C A+G W++P P C  V C        G ++  
Sbjct: 2159 GSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHT 2218

Query: 339  HPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPT-CEAISCEPLESPVHGSM 397
               T   + S  +++C PGY+  G  +  C  + HW +  P  C  + C       +G M
Sbjct: 2219 ---TGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFM 2275

Query: 398  DCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPA-PVCQALQCQDLPVPNE 456
                    F+  +   F C EG+ L G     C   G+W   + P C   +C + P+   
Sbjct: 2276 KGEN----FEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLEN 2331

Query: 457  ARV--NCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLL 514
              V    +   G      V +F+C EG +L G SVL+CL +  WN   P C+ + CTP  
Sbjct: 2332 QLVLKELTTEVG------VVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTP-- 2383

Query: 515  SPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPE 574
             P   +     P  +  + ST ++ C  G+ L G     C   G W+   P C  ++CP+
Sbjct: 2384 -PPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQ 2442

Query: 575  LFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIAS 634
               PE+      D +G   + ST  ++C  GF+L G     C  +G W    PTCK I  
Sbjct: 2443 ---PEEIPNGIIDVQGLAYL-STALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIEC 2498

Query: 635  LPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTA 694
            L       P     G+ +    H      +  T  + CN GF L G S L+C  +G W  
Sbjct: 2499 LK------PKEILNGKFSYTDLH------YGQTVTYSCNRGFRLEGPSALTCLETGDWDV 2546

Query: 695  VTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHW 754
              P+C A+ C      +PI  N      ++SYG+I  + C  G  + G A   C+E+G W
Sbjct: 2547 DAPSCNAIHCDS---PQPIE-NGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG-W 2601

Query: 755  STTVPTC 761
            S+++PTC
Sbjct: 2602 SSSIPTC 2608



 Score =  230 bits (586), Expect = 5e-60
 Identities = 163/613 (26%), Positives = 246/613 (40%), Gaps = 84/613 (13%)

Query: 192  PECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWT 251
            P CE +  CG   +P   L N  H   +F   S  ++ C +GY + G S++ C  +G W 
Sbjct: 1683 PHCERI-SCG---VPPP-LENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWN 1737

Query: 252  NKPPQCL-------------AAQC-----------------------PPLKIPERGNMTC 275
               P CL              A C                        P+K    GN   
Sbjct: 1738 GVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPEN 1797

Query: 276  LHSA-KAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGT 334
             HS+ + +   +  +FSC+EG+ L+G   + C  SG W    P CKAV C     P  G 
Sbjct: 1798 GHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENG- 1856

Query: 335  MDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVH 394
              C+  L AF +GS   + C  GY + G     C+ +  WS   P CE + C   E+  +
Sbjct: 1857 --CIEEL-AFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINN 1913

Query: 395  GSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVP 454
            G       L    Y +  S+ C  G+ L+G  I+ C   G W    P C  + C + P  
Sbjct: 1914 GKY----ILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAI 1969

Query: 455  NEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPC-TPL 513
             +A +  ++    F +++  ++TC EG  L G   ++CLA G W+    +C A+ C  P 
Sbjct: 1970 KDAVITGNN----FTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPP 2025

Query: 514  LSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWT----DSPPMCEA 569
            +       T  +  G  ++     + C +GYSL+   +L C   G+W        P C A
Sbjct: 2026 IVDHASPETAHRLFGDIAF-----YYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIA 2080

Query: 570  IKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTC 629
              C +  +     L+ S ++ +F  GS   F C  GF L     +EC   G+W+ +P + 
Sbjct: 2081 HFCEKPPSVSYSILE-SVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMS- 2138

Query: 630  KGIASLPTPGVQC-PALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRP 688
                      +QC P         M        + F     + CN GF + G+   +C  
Sbjct: 2139 ----------IQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEA 2188

Query: 689  SGQWTAVTPACRAVKCSELHVNKPIAMN--CSNLWGNFSYGSICSFHCLEGQLLNGSAQT 746
            +GQW++  P C  V C E     P   N    +  G   + S   + C  G    GS   
Sbjct: 2189 TGQWSSPIPTCHPVSCGE----PPKVENGFLEHTTGRI-FESEVRYQCNPGYKSVGSPVF 2243

Query: 747  ACQENGHWSTTVP 759
             CQ N HW +  P
Sbjct: 2244 VCQANRHWHSESP 2256



 Score =  220 bits (561), Expect = 4e-57
 Identities = 180/731 (24%), Positives = 287/731 (39%), Gaps = 141/731 (19%)

Query: 105  GTKKALTNEAENWADNEPNNKRNNEDCVEIYIKSP--SAPGK-WNDEHCLKKKHALCYTA 161
            GT++    + +NW ++EP        C+ +   SP  SA G+   DE+  +K+  + YT 
Sbjct: 2809 GTERRTCQDDKNWDEDEP-------ICIPVDCSSPPVSANGQVRGDEYTFQKE--IEYTC 2859

Query: 162  SCQDMSCSKQGECLETIGNYTCSCYPGFYG--PECEYVRECGELELPQHVLMNCSHPLGN 219
            +        +G  LE   +  C     + G  P+C  VR     +L   V         +
Sbjct: 2860 N--------EGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGL-----D 2906

Query: 220  FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSA 279
            + F  + +FHC +GY ++G  KL C + G W  + P C    C P +    G      + 
Sbjct: 2907 YGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHG----FPNG 2962

Query: 280  KAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVH 339
             +F H     + C  G+ L G    +C ++G W+  +P C   +C        GT++   
Sbjct: 2963 FSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCS-TPVIEYGTVNG-- 3019

Query: 340  PLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDC 399
              T F  G + + +C  G+++ GL  + C   G WS+  P CE  SC        GS+  
Sbjct: 3020 --TDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSC--------GSLPM 3069

Query: 400  SPSLRAFQYDTN------CSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLP- 452
             P+  AF  +T+       ++ C  G++++G+  + C   G W+ P PVC+ L C   P 
Sbjct: 3070 IPN--AFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPS 3127

Query: 453  VPNEARVNCSHPF----------GAFRYQSVCSFTCN----------------------- 479
            V N      +H +          G        +FTC                        
Sbjct: 3128 VANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENI 3187

Query: 480  ---------------------EGLLLVGASVLQCLATGNWNSVPP----ECQAIPCTPLL 514
                                 EG    G ++  C   G W   PP     C  + C    
Sbjct: 3188 THILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWE--PPFSDESCSPVSCGKPE 3245

Query: 515  SPQNGTMTCVQPLGSS-SYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCP 573
            SP++G +     +GS  +++ST  + C+ GY L G     C  + +W+    +C+  +C 
Sbjct: 3246 SPEHGFV-----VGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCE 3300

Query: 574  ELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIA 633
                   G  D  +       G    +SC+ G+ LEGP+   CT +G WS   P CK   
Sbjct: 3301 TPLEFLNGKADIENR----TTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCK--- 3353

Query: 634  SLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWT 693
              P P   CP      +  +        F  +      C  GF L G   ++C P   WT
Sbjct: 3354 --PNP---CPVPFVIPENALLSEKE---FYVDQNVSIKCREGFLLQGHGIITCNPDETWT 3405

Query: 694  AVTPACRAVKCS-ELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENG 752
              +  C  + C    HV   IA        ++ YG + ++ C  G +L G  ++ C ENG
Sbjct: 3406 QTSAKCEKISCGPPAHVENAIARGV-----HYQYGDMITYSCYSGYMLEGFLRSVCLENG 3460

Query: 753  HWSTTVPTCQA 763
             W T+ P C+A
Sbjct: 3461 TW-TSPPICRA 3470



 Score =  219 bits (558), Expect = 8e-57
 Identities = 172/660 (26%), Positives = 266/660 (40%), Gaps = 83/660 (12%)

Query: 190  YGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGI 249
            + P   +V    +L L  +VL     P    S  + C    + G  +  P  L  +   +
Sbjct: 1564 FSPAESFVGSISQLNLWDYVLS----PQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKV 1619

Query: 250  WTNKPPQCLAAQCPPLKIPERGNMTCLHSAKA-FQHQSSCSFSCEEGFALVGPEVVQCTA 308
              +       + CP L     G++  L +A    +  S  +  C+ GF LVG  V  C  
Sbjct: 1620 KIDSK-SIFCSDCPRLG----GSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLN 1674

Query: 309  SGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRC 368
             G WT P P C+ + C  +  P E      H    F  GS+  ++C  GY + G   + C
Sbjct: 1675 QGQWTQPLPHCERISCG-VPPPLENGF---HSADDFYAGSTVTYQCNNGYYLLGDSRMFC 1730

Query: 369  IDSGHWSAPLPTC-------------EAISC-----------------------EPLESP 392
             D+G W+   P+C             E  SC                       EP++  
Sbjct: 1731 TDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCK 1790

Query: 393  VHGSMDCSPSL-RAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDL 451
              G+ +   S    +      +F C EG+ L G   + C   G+W    P C+A+ C   
Sbjct: 1791 APGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKP 1850

Query: 452  PVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCT 511
             +P      C     AF + S  ++ CN+G  L G     CLA  +W+  PP C+ + C+
Sbjct: 1851 AIPENG---CIEEL-AFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCS 1906

Query: 512  PLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIK 571
               +  NG       L   +Y ST  + CD GYSL GP  ++CT SG W  +PP C  + 
Sbjct: 1907 SPENINNGKYI----LSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVF 1962

Query: 572  CPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKG 631
            C E  A +    D   T   F   +T  ++C  G+ L G + +EC   G+WS +   C  
Sbjct: 1963 CGEPPAIK----DAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLA 2018

Query: 632  IASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQ 691
            ++    P V   +  T  +             F    ++ C+ G++L  +S L C   G+
Sbjct: 2019 VSCDEPPIVDHASPETAHR------------LFGDIAFYYCSDGYSLADNSQLLCNAQGK 2066

Query: 692  WTAVTPACRAV-KCSELHVNKPIAMNCSNL----WGNFSYGSICSFHCLEGQLLNGSAQT 746
            W  V P  + + +C      KP +++ S L       F+ GS+ SF C+EG +LN SA+ 
Sbjct: 2067 W--VPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKI 2124

Query: 747  ACQENGHWSTTVPTCQAGPLTIQEALTYFGGAVASTIGLIMGGTLLALLRKRFRQKDDGK 806
             C   G W+ +  + Q  P+   E  +   G  AS      G  +     K F  K + K
Sbjct: 2125 ECMRGGQWNPSPMSIQCIPVRCGEPPSIMNG-YASGSNYSFGAMVAYSCNKGFYIKGEKK 2183



 Score =  214 bits (546), Expect = 2e-55
 Identities = 169/650 (26%), Positives = 271/650 (41%), Gaps = 78/650 (12%)

Query: 150  CLKKKHALCYTASCQDMSCSKQGECLETI---GNYTC------SCYPGFY--GPE---CE 195
            CL+ +     +  C+ +SC K    +       NYT        C PG+   G E   C+
Sbjct: 2757 CLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQ 2816

Query: 196  YVRECGELELPQHVLMNCSHPL---------GNFSFNSQCSFHCTDGYQVNGPSKLECLA 246
              +   E E P  + ++CS P            ++F  +  + C +G+ + G     CLA
Sbjct: 2817 DDKNWDEDE-PICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLA 2875

Query: 247  SGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQC 306
            +G W+   P C+  +C     P+  N         F  +   +F C EG+ L G   + C
Sbjct: 2876 NGSWSGATPDCVPVRCATP--PQLANGVTEGLDYGFMKE--VTFHCHEGYILHGAPKLTC 2931

Query: 307  TASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDML 366
             + G W A  P+CK V C   E  + G  +      +F +G   +++C PGY++ G    
Sbjct: 2932 QSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGF----SFIHGGHIQYQCFPGYKLHGNSSR 2987

Query: 367  RCIDSGHWSAPLPTCEAISCEP--LE-SPVHGS-MDCSPSLRAFQYDTNCSFRCAEGFML 422
            RC+ +G WS   P+C    C    +E   V+G+  DC  + R          +C +GF L
Sbjct: 2988 RCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAAR---------IQCFKGFKL 3038

Query: 423  RGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGL 482
             G   + C+  GQW++  P C+   C  LP+   A ++ +  +     ++V +++C  G 
Sbjct: 3039 LGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWK----ENVITYSCRSGY 3094

Query: 483  LLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDE 542
            ++ G+S L C   G W+   P C+ + C    S  N   T      + +Y+S  +  C E
Sbjct: 3095 VIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGE----AHTYESEVKLRCLE 3150

Query: 543  GYSL-SGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGS--LDCSDTRGEFNVGSTCH 599
            GY++ +  +   C + GRW      C   KCP    PE  +  L   D   +F+V     
Sbjct: 3151 GYTMDTDTDTFTCQKDGRWFPERISCSPKKCP---LPENITHILVHGD---DFSVNRQVS 3204

Query: 600  FSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHP 659
             SC  G+  EG N   C   G W   PP      S     V C    +P  G +      
Sbjct: 3205 VSCAEGYTFEGVNISVCQLDGTWE--PPFSDESCS----PVSCGKPESPEHGFVV----G 3254

Query: 660  GTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIA-MNCS 718
              + F +T  + C  G+ L G+    C+ + QW+     C+  +C       P+  +N  
Sbjct: 3255 SKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCET-----PLEFLNGK 3309

Query: 719  NLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTI 768
                N + G    + C  G  L G ++  C ENG WS  VP C+  P  +
Sbjct: 3310 ADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPV 3359



 Score =  213 bits (542), Expect = 6e-55
 Identities = 166/612 (27%), Positives = 238/612 (38%), Gaps = 76/612 (12%)

Query: 192  PECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWT 251
            P C  V  CGE    ++  +   H  G   F S+  + C  GY+  G     C A+  W 
Sbjct: 2197 PTCHPV-SCGEPPKVENGFLE--HTTGRI-FESEVRYQCNPGYKSVGSPVFVCQANRHWH 2252

Query: 252  NKPP-QCLAAQC---PPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCT 307
            ++ P  C+   C   PP+   + G M      + F+  S   F C EG+ LVG     C 
Sbjct: 2253 SESPLMCVPLDCGKPPPI---QNGFM----KGENFEVGSKVQFFCNEGYELVGDSSWTCQ 2305

Query: 308  ASGVWTAPA-PVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDML 366
             SG W   + P C   +C   E P       +  LT         F C+ G+ ++G  +L
Sbjct: 2306 KSGKWNKKSNPKCMPAKCP--EPPLLENQLVLKELTTEV--GVVTFSCKEGHVLQGPSVL 2361

Query: 367  RCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGAD 426
            +C+ S  W+   P C+ + C P   P   S        A  + +   + C  GF LRG  
Sbjct: 2362 KCLPSQQWNDSFPVCKIVLCTP---PPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNS 2418

Query: 427  IVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVG 486
               C   G W++P P C  ++C   P P E         G   Y S   +TC  G  LVG
Sbjct: 2419 TTLCQPDGTWSSPLPECVPVEC---PQPEEIPNGIIDVQG-LAYLSTALYTCKPGFELVG 2474

Query: 487  ASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSL 546
             +   C   G+W    P C+AI C       NG  +         Y  T  + C+ G+ L
Sbjct: 2475 NTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTD----LHYGQTVTYSCNRGFRL 2530

Query: 547  SGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGF 606
             GP  L C  +G W    P C AI C      E G ++ +D    ++ G+   +SC  GF
Sbjct: 2531 EGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGAD----YSYGAIIIYSCFPGF 2586

Query: 607  KLEGPNNVECTTSGRWSATPPTCKGIAS-------------------------------- 634
            ++ G     C  SG WS++ PTC  I                                  
Sbjct: 2587 QVAGHAMQTCEESG-WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPY 2645

Query: 635  -LPTPGVQCPALTTPGQGTMYC-RHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQW 692
              P P     A+    + T      H   F + T   + CN G+ L+G+  L C+  G W
Sbjct: 2646 VTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTW 2705

Query: 693  TAVTPACRAVKCSELHVNKPIAMNCSNL-WGNFSYGSICSFHCLEGQLLNGSAQTACQEN 751
                P+C +++C     + P A     L +   S GS   + C  G +L GS    C EN
Sbjct: 2706 NGSAPSCISIEC-----DLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLEN 2760

Query: 752  GHWSTTVPTCQA 763
              WS   P C+A
Sbjct: 2761 RKWSGASPRCEA 2772



 Score =  200 bits (508), Expect = 5e-51
 Identities = 172/700 (24%), Positives = 263/700 (37%), Gaps = 95/700 (13%)

Query: 110  LTNEAENWADNEPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHALCYTASCQDMSCS 169
            L N    W    P   ++   C+  + + P +      E   K K A     S + M   
Sbjct: 2060 LCNAQGKWV---PPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCM--- 2113

Query: 170  KQGECLETIGNYTC----SCYPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQ 225
             +G  L T     C       P     +C  VR CGE       +MN      N+SF + 
Sbjct: 2114 -EGFVLNTSAKIECMRGGQWNPSPMSIQCIPVR-CGE----PPSIMNGYASGSNYSFGAM 2167

Query: 226  CSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQ 285
             ++ C  G+ + G  K  C A+G W++  P C    C      E G    L        +
Sbjct: 2168 VAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENG---FLEHTTGRIFE 2224

Query: 286  SSCSFSCEEGFALVGPEVVQCTASGVWTAPAPV-CKAVQCQHLEAPSEGTMDCVHPLTAF 344
            S   + C  G+  VG  V  C A+  W + +P+ C  + C        G M   +    F
Sbjct: 2225 SEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGEN----F 2280

Query: 345  AYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLR 404
              GS  +F C  GY + G     C  SG W+          C P + P    ++    L+
Sbjct: 2281 EVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNP----KCMPAKCPEPPLLENQLVLK 2336

Query: 405  AFQYDTNC-SFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSH 463
                +    +F C EG +L+G  +++C    QW    PVC+ + C   P+ +        
Sbjct: 2337 ELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLIS---FGVPI 2393

Query: 464  PFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTC 523
            P  A  + S   ++C  G  L G S   C   G W+S  PEC  + C       NG +  
Sbjct: 2394 PSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIID- 2452

Query: 524  VQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSL 583
            VQ L   +Y ST  + C  G+ L G     C  +G W    P C+AI+C +      G  
Sbjct: 2453 VQGL---AYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKF 2509

Query: 584  DCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCP 643
              +D     + G T  +SC+ GF+LEGP+ + C  +G W    P+C  I         C 
Sbjct: 2510 SYTD----LHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAI--------HCD 2557

Query: 644  ALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVK 703
            +      G +        + +     + C  GF + G +  +C  SG W++  P C  + 
Sbjct: 2558 SPQPIENGFV----EGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG-WSSSIPTCMPID 2612

Query: 704  CS-ELHV-----------------------------NKPIAMNC-SNLW----------- 721
            C    H+                             + P  +   +  W           
Sbjct: 2613 CGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHS 2672

Query: 722  GNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
             NF YG++ S+ C  G  L G+    CQE+G W+ + P+C
Sbjct: 2673 SNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSC 2712



 Score =  174 bits (440), Expect = 4e-43
 Identities = 153/615 (24%), Positives = 225/615 (36%), Gaps = 120/615 (19%)

Query: 202  ELELPQHVLMNCSHPL-------GNFSF--NSQCSFHCTDGYQVNGPSKLECLASGIWTN 252
            + E+P    +NC  P          FSF       + C  GY+++G S   CL++G W+ 
Sbjct: 2938 DAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSG 2997

Query: 253  KPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVW 312
              P CL  +C    I E G +    +   F    +    C +GF L+G   + C A G W
Sbjct: 2998 SSPSCLPCRCSTPVI-EYGTV----NGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQW 3052

Query: 313  TAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCK-----FECQPGYRVRGLDMLR 367
            ++  P C+   C        G++  + P    +  SS K     + C+ GY ++G   L 
Sbjct: 3053 SSGFPHCEHTSC--------GSLPMI-PNAFISETSSWKENVITYSCRSGYVIQGSSDLI 3103

Query: 368  CIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFML-RGAD 426
            C + G WS P P CE +SC    S  +       +  A  Y++    RC EG+ +    D
Sbjct: 3104 CTEKGVWSQPYPVCEPLSCGSPPSVANAVA----TGEAHTYESEVKLRCLEGYTMDTDTD 3159

Query: 427  IVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVG 486
               C   G+W      C   +C   P+P        H    F      S +C EG    G
Sbjct: 3160 TFTCQKDGRWFPERISCSPKKC---PLPENITHILVHG-DDFSVNRQVSVSCAEGYTFEG 3215

Query: 487  ASVLQCLATGNWNSVPP----ECQAIPCTPLLSPQNGTMT-------------------- 522
             ++  C   G W   PP     C  + C    SP++G +                     
Sbjct: 3216 VNISVCQLDGTWE--PPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYEL 3273

Query: 523  -------------------------CVQPLGSSSYKSTCQ---------FICDEGYSLSG 548
                                     C  PL   + K+  +         + C+ GYSL G
Sbjct: 3274 EGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEG 3333

Query: 549  PERLDCTRSGRWTDSPPMCEAIKCPELFA-PEQGSLDCSDTRGEFNVGSTCHFSCDNGFK 607
            P    CT +G W+   P+C+   CP  F  PE   L    +  EF V       C  GF 
Sbjct: 3334 PSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALL----SEKEFYVDQNVSIKCREGFL 3389

Query: 608  LEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTT 667
            L+G   + C     W+ T   C+ I+  P   V+        +G  Y         +   
Sbjct: 3390 LQGHGIITCNPDETWTQTSAKCEKISCGPPAHVE----NAIARGVHY--------QYGDM 3437

Query: 668  CYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAV---KCSELHV-NKPIAMNCSNLW-G 722
              + C +G+ L G     C  +G WT+  P CRAV    C    +  +P A +C   W G
Sbjct: 3438 ITYSCYSGYMLEGFLRSVCLENGTWTS-PPICRAVCRFPCQNGGICQRPNACSCPEGWMG 3496

Query: 723  NFSYGSICSFHCLEG 737
                  IC   CL G
Sbjct: 3497 RLCEEPICILPCLNG 3511



 Score =  140 bits (354), Expect = 4e-33
 Identities = 114/428 (26%), Positives = 172/428 (40%), Gaps = 66/428 (15%)

Query: 205  LPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPP----QCLAA 260
            LP+++     H   +FS N Q S  C +GY   G +   C   G W  +PP     C   
Sbjct: 3183 LPENITHILVHG-DDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTW--EPPFSDESCSPV 3239

Query: 261  QCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCK 320
             C   + PE G +        +  +S+  + CE G+ L G     C  +  W+    +CK
Sbjct: 3240 SCGKPESPEHGFVV----GSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICK 3295

Query: 321  AVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPT 380
              +C+       G  D  +  T    G +  + C  GY + G     C ++G WS P+P 
Sbjct: 3296 ETRCETPLEFLNGKADIENRTT----GPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPL 3351

Query: 381  CEAISCE-PLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAP 439
            C+   C  P   P +  +    S + F  D N S +C EGF+L+G  I+ C+    WT  
Sbjct: 3352 CKPNPCPVPFVIPENALL----SEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQT 3407

Query: 440  APVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWN 499
            +  C+ + C        A     H    ++Y  + +++C  G +L G     CL  G W 
Sbjct: 3408 SAKCEKISCGPPAHVENAIARGVH----YQYGDMITYSCYSGYMLEGFLRSVCLENGTWT 3463

Query: 500  SVPPECQAI---PCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTR 556
            S PP C+A+   PC      QNG + C +P   S  +     +C+E   +     L C  
Sbjct: 3464 S-PPICRAVCRFPC------QNGGI-CQRPNACSCPEGWMGRLCEEPICI-----LPCLN 3510

Query: 557  SGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFS-----CDNGFKLEGP 611
             GR   +P  C+   CP  +                  GS CH +     C NG K   P
Sbjct: 3511 GGRCV-APYQCD---CPPGWT-----------------GSRCHTAVCQSPCLNGGKCVRP 3549

Query: 612  NNVECTTS 619
            N   C +S
Sbjct: 3550 NRCHCLSS 3557



 Score =  122 bits (307), Expect = 1e-27
 Identities = 84/306 (27%), Positives = 124/306 (40%), Gaps = 36/306 (11%)

Query: 168 CSKQGECL--ETIGNYTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQ 225
           C + G C      G++ C C  G+YG   +Y  EC       +       P G+    S 
Sbjct: 288 CDRMGSCKCGTHTGHFECICEKGYYGKGLQY--ECTACPSGTY------KPEGSPGGISS 339

Query: 226 CSFHCTDGYQVNGP---SKLECLASGIWTNKPPQCLAAQCPPLKIPERG---NMTCLHSA 279
           C   C D    + P   S  +C+    +      C    CP LK PE G     TC +  
Sbjct: 340 C-IPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHF 398

Query: 280 KAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVH 339
            A     +C   C  GF LVG  ++ C  +G+W+     C+   C HL  P  G + C  
Sbjct: 399 NA-----ACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISC-- 451

Query: 340 PLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESP---VHGS 396
                 Y ++C   C  GYR+ G D L C  +  W  P P C    C   + P   +   
Sbjct: 452 STREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISP 511

Query: 397 MDCSPSLRAFQYDTNCSFRCAEGFMLRGA-DIVRCDNLGQWTAPAPVCQALQCQDLPVPN 455
            +C    +  ++ T C   C +GF+L G  +++RC   G+W       QA  C+D+  P 
Sbjct: 512 HNCGK--QPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGV---QAAVCKDVEAP- 565

Query: 456 EARVNC 461
             ++NC
Sbjct: 566 --QINC 569



 Score =  109 bits (272), Expect = 1e-23
 Identities = 60/216 (27%), Positives = 93/216 (43%), Gaps = 13/216 (6%)

Query: 306 CTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDM 365
           C     + A    C+ V C  L+ P  G    +       + ++C   C PG+ + G  +
Sbjct: 360 CVCREGYRASGQTCELVHCPALKPPENGYF--IQNTCNNHFNAACGVRCHPGFDLVGSSI 417

Query: 366 LRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGA 425
           + C+ +G WS     C   +C  L  P HG + CS   R   Y T C   C EG+ L G+
Sbjct: 418 ILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCST--REMLYKTTCLVACDEGYRLEGS 475

Query: 426 DIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARV---NCSHPFGAFRYQSVCSFTCNEGL 482
           D + C    QW  P P C    C    +P +  +   NC       ++ ++C  +C +G 
Sbjct: 476 DKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQ--PAKFGTICYVSCRQGF 533

Query: 483 LLVGA-SVLQCLATGNWNSVPPECQAIPCTPLLSPQ 517
           +L G   +L+C  +G WN      QA  C  + +PQ
Sbjct: 534 ILSGVKEMLRCTTSGKWN---VGVQAAVCKDVEAPQ 566



 Score =  107 bits (268), Expect = 3e-23
 Identities = 64/217 (29%), Positives = 97/217 (44%), Gaps = 21/217 (9%)

Query: 436 WTAPAPVCQALQCQDLPVPNEA---RVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQC 492
           + A    C+ + C  L  P      +  C++ F A      C   C+ G  LVG+S++ C
Sbjct: 366 YRASGQTCELVHCPALKPPENGYFIQNTCNNHFNA-----ACGVRCHPGFDLVGSSIILC 420

Query: 493 LATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERL 552
           L  G W+     C+   C  L  P++G ++C        YK+TC   CDEGY L G ++L
Sbjct: 421 LPNGLWSGSESYCRVRTCPHLRQPKHGHISC--STREMLYKTTCLVACDEGYRLEGSDKL 478

Query: 553 DCTRSGRWTDSPPMCEAIKCPELFAPEQGSL---DCSDTRGEFNVGSTCHFSCDNGFKLE 609
            C  + +W    P C    C     P+   +   +C     +F  G+ C+ SC  GF L 
Sbjct: 479 TCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKF--GTICYVSCRQGFILS 536

Query: 610 GPNN-VECTTSGRWS--ATPPTCKGIASLPTPGVQCP 643
           G    + CTTSG+W+       CK + +   P + CP
Sbjct: 537 GVKEMLRCTTSGKWNVGVQAAVCKDVEA---PQINCP 570



 Score =  106 bits (264), Expect = 1e-22
 Identities = 64/232 (27%), Positives = 110/232 (47%), Gaps = 25/232 (10%)

Query: 183 CSCYPGFY--GPECEYVRECGELELPQH---VLMNCSHPLGNFSFNSQCSFHCTDGYQVN 237
           C C  G+   G  CE V  C  L+ P++   +   C     N  FN+ C   C  G+ + 
Sbjct: 360 CVCREGYRASGQTCELVH-CPALKPPENGYFIQNTC-----NNHFNAACGVRCHPGFDLV 413

Query: 238 GPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFA 297
           G S + CL +G+W+     C    CP L+ P+ G+++C  S +   ++++C  +C+EG+ 
Sbjct: 414 GSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISC--STREMLYKTTCLVACDEGYR 471

Query: 298 LVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSE---GTMDCVHPLTAFAYGSSCKFEC 354
           L G + + C  +  W  P P C    C   + P +      +C      F  G+ C   C
Sbjct: 472 LEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKF--GTICYVSC 529

Query: 355 QPGYRVRGL-DMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRA 405
           + G+ + G+ +MLRC  SG W+  +   +A  C+ +E+P    ++C   + A
Sbjct: 530 RQGFILSGVKEMLRCTTSGKWNVGV---QAAVCKDVEAP---QINCPKDIEA 575



 Score = 96.7 bits (239), Expect = 8e-20
 Identities = 84/317 (26%), Positives = 123/317 (38%), Gaps = 49/317 (15%)

Query: 464 PFGAFRYQSV--CSFTCNEGLLLVG----------ASVLQCLATGNW--NSVPPECQAIP 509
           P G+F    +  CS+ C+EG                   +C+    +    +  EC A P
Sbjct: 265 PSGSFIQDDMVHCSYLCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACP 324

Query: 510 CTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSL----SGPERLDCTRSGRWTDSPP 565
                   +GT    +P GS    S+C    DE ++     + PE  DC     +  S  
Sbjct: 325 --------SGTY---KPEGSPGGISSCIPCPDENHTSPPGSTSPE--DCVCREGYRASGQ 371

Query: 566 MCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSAT 625
            CE + CP L  PE G    +     FN  + C   C  GF L G + + C  +G WS +
Sbjct: 372 TCELVHCPALKPPENGYFIQNTCNNHFN--AACGVRCHPGFDLVGSSIILCLPNGLWSGS 429

Query: 626 PPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLS 685
              C+           CP L  P  G + C      +   TTC   C+ G+ L G   L+
Sbjct: 430 ESYCRVRT--------CPHLRQPKHGHISCSTREMLY--KTTCLVACDEGYRLEGSDKLT 479

Query: 686 CRPSGQWTAVTPACRAVKCSELHVNKPIAM---NCSNLWGNFSYGSICSFHCLEGQLLNG 742
           C+ + QW    P C    CS   + K + +   NC      F  G+IC   C +G +L+G
Sbjct: 480 CQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKF--GTICYVSCRQGFILSG 537

Query: 743 -SAQTACQENGHWSTTV 758
                 C  +G W+  V
Sbjct: 538 VKEMLRCTTSGKWNVGV 554



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 70/245 (28%), Positives = 90/245 (36%), Gaps = 47/245 (19%)

Query: 536 CQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVG 595
           C ++CDEG          C R G          + KC        G  +C   +G +  G
Sbjct: 277 CSYLCDEGKDC-------CDRMG----------SCKC----GTHTGHFECICEKGYYGKG 315

Query: 596 STCHFS-CDNG-FKLEG---------PNNVECTTSGRWSATPPTCKGIASLPTPG----- 639
                + C +G +K EG         P   E  TS   S +P  C         G     
Sbjct: 316 LQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCEL 375

Query: 640 VQCPALTTPGQGTMY---CRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVT 696
           V CPAL  P  G      C +H     FN  C   C+ GF L+G S + C P+G W+   
Sbjct: 376 VHCPALKPPENGYFIQNTCNNH-----FNAACGVRCHPGFDLVGSSIILCLPNGLWSGSE 430

Query: 697 PACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWST 756
             CR   C  L   K   ++CS       Y + C   C EG  L GS +  CQ N  W  
Sbjct: 431 SYCRVRTCPHLRQPKHGHISCST--REMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDG 488

Query: 757 TVPTC 761
             P C
Sbjct: 489 PEPRC 493



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 15/39 (38%), Positives = 21/39 (53%)

Query: 163  CQDMSCSKQGECLETIGNYTCSCYPGFYGPECEYVRECG 201
            CQ   C  Q  C++ + +Y+C C PGF G  CE  +  G
Sbjct: 1387 CQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTG 1425



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 40/162 (24%), Positives = 61/162 (37%), Gaps = 27/162 (16%)

Query: 163  CQDMSCSKQGECLETIGNYTCSCYPGFYGPECE-YVRECGELELPQHVLMNCSHPLGNF- 220
            C    C  +G C++ +  Y C+C  GF G  CE  V EC       + +  C   +G F 
Sbjct: 1273 CSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAV--CEDQVGGFL 1330

Query: 221  ------SFNSQC--------SFHCTDGYQV-NGPSKLECLASGIWTNKPPQCLAAQCPPL 265
                     ++C        S  C +G    +G +   CL +  +T        + C  L
Sbjct: 1331 CKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFT-------GSHC-EL 1382

Query: 266  KIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCT 307
             I E  +  C + A      +S S  C+ GF+    E  Q T
Sbjct: 1383 NINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQST 1424



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 47/216 (21%), Positives = 73/216 (33%), Gaps = 57/216 (26%)

Query: 163  CQDMSCSKQGECLETIGNYTCSCYPGFYGPEC-EYVRECGELE-LPQHVLMNCSHPLGNF 220
            C  + C   G C + +G + C C  G+ G  C E + EC     L + + ++     G  
Sbjct: 1235 CSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVD-----GVA 1289

Query: 221  SFNSQC-----SFHCTDGYQVNGPSKLECLASGIWTNK--------PPQCLAAQCPP--- 264
             +   C       HC    +VN      CL + +  ++        PP  L  +C     
Sbjct: 1290 GYRCTCVKGFVGLHCET--EVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVD 1347

Query: 265  --LKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAV 322
              L  P +   TC   A +F                      +C  +  +T         
Sbjct: 1348 ECLSQPCKNGATCKDGANSF----------------------RCLCAAGFTGSHCELNIN 1385

Query: 323  QCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGY 358
            +CQ    P      CV  L ++    SCK  CQPG+
Sbjct: 1386 ECQ--SNPCRNQATCVDELNSY----SCK--CQPGF 1413



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 49/188 (26%), Positives = 63/188 (33%), Gaps = 48/188 (25%)

Query: 584 DCSDTRGEFNVGS-TCHFSC--DNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGV 640
           DC D  G    G+ T HF C  + G+  +G    ECT     +  P    G  S   P  
Sbjct: 286 DCCDRMGSCKCGTHTGHFECICEKGYYGKGLQ-YECTACPSGTYKPEGSPGGISSCIP-- 342

Query: 641 QCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACR 700
            CP             +H    G  +     C  G+          R SGQ       C 
Sbjct: 343 -CPD-----------ENHTSPPGSTSPEDCVCREGY----------RASGQ------TCE 374

Query: 701 AVKCSELHVNKP------IAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHW 754
            V C  L   KP      I   C+N      + + C   C  G  L GS+   C  NG W
Sbjct: 375 LVHCPAL---KPPENGYFIQNTCNN-----HFNAACGVRCHPGFDLVGSSIILCLPNGLW 426

Query: 755 STTVPTCQ 762
           S +   C+
Sbjct: 427 SGSESYCR 434


>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
          Length = 3565

 Score =  251 bits (642), Expect = 1e-66
 Identities = 169/607 (27%), Positives = 253/607 (41%), Gaps = 72/607 (11%)

Query: 184  SCYPGFY--------------------GPECEYVRECGELELPQHVLMNCSHPLGNFS-F 222
            SC PG+Y                     P C  +  CG L  P +      + +G  + +
Sbjct: 2588 SCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVI-SCGSLSFPPN-----GNKIGTLTVY 2641

Query: 223  NSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAF 282
             +   F C  GY + G    ECLA+G+W+    +CLA  C        G++    S   F
Sbjct: 2642 GATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCGSPDPIVNGHI----SGDGF 2697

Query: 283  QHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLT 342
             ++ +  + C  GF LVG  V  C     W+   PVC  + C H   P+ G  +     +
Sbjct: 2698 SYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGFTNG----S 2753

Query: 343  AFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEP---LESPV-HGSMD 398
             F       F C  GY ++G+   +C  +G WS+PLPTC  ++C     +E+ + HG  +
Sbjct: 2754 EFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQN 2813

Query: 399  CSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEAR 458
               S   F+Y  +  + C +GF L G+  + C   G W    P C A+ C    VP  A 
Sbjct: 2814 FPES---FEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAV 2870

Query: 459  VNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQN 518
            +        F Y +V  ++C     L+G     C    +W+   P C      P      
Sbjct: 2871 LTGE----LFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTG--NNPGFCGDP 2924

Query: 519  GTMTCVQPLGSS-SYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFA 577
            GT      LG     KS  +F C+ G+ L G     C  +G W+   P+CEA+ C     
Sbjct: 2925 GTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGT 2984

Query: 578  PEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPT 637
            P  G +  SD        S+  ++C  G+K  G     CT +G W+ T P C  I S   
Sbjct: 2985 PTNGMIVSSD---GILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCT-IISCGD 3040

Query: 638  PGVQCPALTTPGQGTMYCRHHPGT-FGFNTTCYFGCNAGFTL--IGDSTLSCRPSGQWTA 694
            PG       T   G  +     GT F FN T  + CN G+ +  +  +T+ C   G+W  
Sbjct: 3041 PG-------TLANGIQF-----GTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNP 3088

Query: 695  VTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHW 754
              P C+AV C +     P   N +    +F +GS  S+ C++G  L+ SA  +C+  G W
Sbjct: 3089 SKPVCKAVLCPQ----PPPVQNGTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVW 3144

Query: 755  STTVPTC 761
               +P C
Sbjct: 3145 KGEIPQC 3151



 Score =  224 bits (572), Expect = 2e-58
 Identities = 150/568 (26%), Positives = 231/568 (40%), Gaps = 41/568 (7%)

Query: 200  CGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLA 259
            CG    P H   N S     F+ N   +F C  GY + G S+ +C ++G W++  P C  
Sbjct: 2739 CGHPGNPAHGFTNGSE----FNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTCRV 2794

Query: 260  AQCPPLKIPERGNMTCLHS-AKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPV 318
              C      E        +  ++F++  S  + C++GF L+G   + C A+G+W    P 
Sbjct: 2795 VNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPK 2854

Query: 319  CKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPL 378
            C A+ C H   P+   +        F YG+   + C+    + G D   C +  HWS  L
Sbjct: 2855 CLAISCGHPGVPANAVLTG----ELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGAL 2910

Query: 379  PTCEAIS---CEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ 435
            P C   +   C    +P HGS         F+  +   F C  G  LRG+    C   G 
Sbjct: 2911 PHCTGNNPGFCGDPGTPAHGSRLGDD----FKTKSLLRFSCEMGHQLRGSPERTCLLNGS 2966

Query: 436  WTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLAT 495
            W+   PVC+A+ C +   P    +  S       + S   + C EG    G     C A 
Sbjct: 2967 WSGLQPVCEAVSCGNPGTPTNGMIVSS---DGILFSSSVIYACWEGYKTSGLMTRHCTAN 3023

Query: 496  GNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSG--PERLD 553
            G W    P+C  I C    +  NG    +Q     ++  T  + C+ GY +       + 
Sbjct: 3024 GTWTGTAPDCTIISCGDPGTLANG----IQFGTDFTFNKTVSYQCNPGYVMEAVTSATIR 3079

Query: 554  CTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNN 613
            CT+ GRW  S P+C+A+ CP+    + G+++ SD    F  GS+  +SC +G++L     
Sbjct: 3080 CTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGSD----FRWGSSISYSCMDGYQLSHSAI 3135

Query: 614  VECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCN 673
            + C   G W    P C     LP   V C     P +G +  +    +F + +  +F C 
Sbjct: 3136 LSCEGRGVWKGEIPQC-----LP---VFCGDPGIPAEGRLSGK----SFTYKSEVFFQCK 3183

Query: 674  AGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFH 733
            + F L+G S   C+  G W+ + P C     +             N    +  GS   F 
Sbjct: 3184 SPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFR 3243

Query: 734  CLEGQLLNGSAQTACQENGHWSTTVPTC 761
            C +G  + GS    C  N  WS     C
Sbjct: 3244 CRKGYHIQGSTTRTCLANLTWSGIQTEC 3271



 Score =  207 bits (526), Expect = 4e-53
 Identities = 163/603 (27%), Positives = 238/603 (39%), Gaps = 59/603 (9%)

Query: 214  SHPLGNFSF--------NSQCSFHCTDGYQVNGPSKLECLASGI----WTNKPPQCLAAQ 261
            +HPL N            S+  + C  GY++ G S   C  + +    W +  P C A  
Sbjct: 2436 THPLKNGGILNRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVS 2495

Query: 262  CPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPE--VVQCTASGVWT--APAP 317
            C   + P  G+ T       F   S   + C EGF L   +     C   G+W+     P
Sbjct: 2496 CGIPESPGNGSFT----GNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPP 2551

Query: 318  VCKAVQCQHLEAP-SEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSA 376
             CK V C  +EA  SE  +  +   +   YG+     C PGY + G  +LRC  +G W+ 
Sbjct: 2552 TCKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNI 2611

Query: 377  --PLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLG 434
                P+C  ISC  L  P +G+   + ++    Y     F C  G+ L G+ +  C   G
Sbjct: 2612 GDERPSCRVISCGSLSFPPNGNKIGTLTV----YGATAIFTCNTGYTLVGSHVRECLANG 2667

Query: 435  QWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLA 494
             W+     C A  C   P P    VN       F Y+    + CN G  LVG SV  CL 
Sbjct: 2668 LWSGSETRCLAGHCGS-PDPI---VNGHISGDGFSYRDTVVYQCNPGFRLVGTSVRICLQ 2723

Query: 495  TGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSS-SYKSTCQFICDEGYSLSGPERLD 553
               W+   P C  I C    +P +G        GS  +      F C+ GY L G  R  
Sbjct: 2724 DHKWSGQTPVCVPITCGHPGNPAHGFTN-----GSEFNLNDVVNFTCNTGYLLQGVSRAQ 2778

Query: 554  CTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGE-FNVGSTCHFSCDNGFKLEGPN 612
            C  +G+W+   P C  + C +    E           E F  G +  + C  GF L G +
Sbjct: 2779 CRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSS 2838

Query: 613  NVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGC 672
             + C  +G W  + P C  I S   PGV   A+ T   G +        F +    ++ C
Sbjct: 2839 ALTCMANGLWDRSLPKCLAI-SCGHPGVPANAVLT---GEL--------FTYGAVVHYSC 2886

Query: 673  NAGFTLIGDSTLSCRPSGQWTAVTPACRAVK---CSELHVNKPIAMNCSNLWGNFSYGSI 729
                +LIG+ T  C+    W+   P C       C +         + S L  +F   S+
Sbjct: 2887 RGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGD----PGTPAHGSRLGDDFKTKSL 2942

Query: 730  CSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEALTYFGGAVASTIGLIMGG 789
              F C  G  L GS +  C  NG WS   P C+A  ++     T   G + S+ G++   
Sbjct: 2943 LRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEA--VSCGNPGTPTNGMIVSSDGILFSS 3000

Query: 790  TLL 792
            +++
Sbjct: 3001 SVI 3003



 Score =  206 bits (525), Expect = 5e-53
 Identities = 157/626 (25%), Positives = 249/626 (39%), Gaps = 65/626 (10%)

Query: 175  LETIGNYTCSCYPGFYGPECEYVRECGELE--LPQHVLMNCSHP--------------LG 218
            L  + N+TC+      G      R  G+    LP   ++NCS P                
Sbjct: 2757 LNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPE 2816

Query: 219  NFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHS 278
            +F +     +HC  G+ + G S L C+A+G+W    P+CLA  C    +P    +T    
Sbjct: 2817 SFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAVLT---- 2872

Query: 279  AKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQ---CQHLEAPSEGTM 335
             + F + +   +SC    +L+G +   C     W+   P C       C     P+ G+ 
Sbjct: 2873 GELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGS- 2931

Query: 336  DCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHG 395
                    F   S  +F C+ G+++RG     C+ +G WS   P CEA+SC    +P +G
Sbjct: 2932 ---RLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNG 2988

Query: 396  SMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPN 455
             +  S  +    + ++  + C EG+   G     C   G WT  AP C  + C D     
Sbjct: 2989 MIVSSDGIL---FSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGD----- 3040

Query: 456  EARVNCSHPFGA-FRYQSVCSFTCNEGLLL--VGASVLQCLATGNWNSVPPECQAIPCTP 512
               +     FG  F +    S+ CN G ++  V ++ ++C   G WN   P C+A+ C  
Sbjct: 3041 PGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQ 3100

Query: 513  LLSPQNGTMTCVQPLGSS-SYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIK 571
                QNGT+      GS   + S+  + C +GY LS    L C   G W    P C  + 
Sbjct: 3101 PPPVQNGTVE-----GSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVF 3155

Query: 572  CPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKG 631
            C +   P +G L        F   S   F C + F L G +   C   G WS   PTC  
Sbjct: 3156 CGDPGIPAEGRLSGKS----FTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCID 3211

Query: 632  IA--SLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPS 689
             A  + P PG     +    +G          +   +T +F C  G+ + G +T +C  +
Sbjct: 3212 PAHNTCPDPGTPHFGIQNSSRG----------YEVGSTVFFRCRKGYHIQGSTTRTCLAN 3261

Query: 690  GQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLL-NGSAQTAC 748
              W+ +   C    C +        +   +L    ++G    + C  G  L  GS    C
Sbjct: 3262 LTWSGIQTECIPHACRQPETPAHADVRAIDL---PTFGYTLVYTCHPGFFLAGGSEHRTC 3318

Query: 749  QENGHWSTTVPTCQA-GPLTIQEALT 773
            + +  W+   P C++ G   + E +T
Sbjct: 3319 KADMKWTGKSPVCKSKGVREVNETVT 3344



 Score =  150 bits (378), Expect = 6e-36
 Identities = 106/415 (25%), Positives = 163/415 (39%), Gaps = 25/415 (6%)

Query: 160  TASCQDMSCSKQGECLETIGNYTCSCYPGFYG--PECEYVRECGELELPQHVLMNCSHPL 217
            T S    SC + G  L      TC     + G  P CE V  CG    P + ++  S  +
Sbjct: 2939 TKSLLRFSC-EMGHQLRGSPERTCLLNGSWSGLQPVCEAV-SCGNPGTPTNGMIVSSDGI 2996

Query: 218  GNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLH 277
                F+S   + C +GY+ +G     C A+G WT   P C    C        G    + 
Sbjct: 2997 ---LFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLANG----IQ 3049

Query: 278  SAKAFQHQSSCSFSCEEGFAL--VGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTM 335
                F    + S+ C  G+ +  V    ++CT  G W    PVCKAV C        GT+
Sbjct: 3050 FGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTV 3109

Query: 336  DCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHG 395
            +     + F +GSS  + C  GY++    +L C   G W   +P C  + C     P  G
Sbjct: 3110 EG----SDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEG 3165

Query: 396  SMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPN 455
             +    S ++F Y +   F+C   F+L G+    C   G W+   P C        P P 
Sbjct: 3166 RL----SGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPDPG 3221

Query: 456  EARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLS 515
                   +    +   S   F C +G  + G++   CLA   W+ +  EC    C     
Sbjct: 3222 TPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACR---Q 3278

Query: 516  PQNGTMTCVQPLGSSSYKSTCQFICDEGYSLS-GPERLDCTRSGRWTDSPPMCEA 569
            P+      V+ +   ++  T  + C  G+ L+ G E   C    +WT   P+C++
Sbjct: 3279 PETPAHADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCKS 3333



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 102/453 (22%), Positives = 153/453 (33%), Gaps = 105/453 (23%)

Query: 286  SSCSFSCEEGFALV-GPEVVQCTASG---VWTAPAPVCKAVQCQHLEAPSEGTMDCVHPL 341
            SS SF C++GF    G E + C       VW++  P C+A    HL A S   +    P 
Sbjct: 718  SSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWP- 776

Query: 342  TAFAYGSSCKF--ECQPGYRVRGLDMLRCIDSGHWSAPLPTCEA----ISCEPLESPVHG 395
              +     C++  E +PG+ ++        D         T E      S  PL    HG
Sbjct: 777  GYYKDSLHCEWIIEAKPGHSIK-----ITFDRFQTEVNYDTLEVRDGPASSSPLIGEYHG 831

Query: 396  SMDCSP----SLRAFQY--DTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQ 449
            +   +P    S   F Y   T  + R + GF++    +                ++  C 
Sbjct: 832  TQ--APQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVT--------------LESDSCL 875

Query: 450  DLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIP 509
            D  +P    VN     G F  +S  +F+C+ G  L     L C     WN   P C A+ 
Sbjct: 876  DPGIP----VNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDAL- 930

Query: 510  CTPLLSPQNGT-------------MTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTR 556
            C   +  ++GT             + C   +  S  K   Q I    +  S  + L  T 
Sbjct: 931  CGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGV-QMIFHTFHLESSHDYLLITE 989

Query: 557  SGRWTDSPPMCEAIKCPE-----LFAPEQGSL----DCSDTRGEFNV------------- 594
             G +++          P      LF      L    D S +   FN+             
Sbjct: 990  DGSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYDLEPCDDP 1049

Query: 595  ---------------GSTCHFSCDNGFKLEGPNNVECTTSGR--WSATPPTCKGIASLPT 637
                           G +  FSC  G++LEG   + C   GR  WSA  P C        
Sbjct: 1050 GVPAFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCV------- 1102

Query: 638  PGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYF 670
               +C A     +GT+   + P  +  N  C +
Sbjct: 1103 --AECGASVKGNEGTLLSPNFPSNYDNNHECIY 1133



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 100/447 (22%), Positives = 146/447 (32%), Gaps = 81/447 (18%)

Query: 282  FQHQSSCSFSCEEGFALVGPEVVQCTASG----VWTAPAPVCKAVQCQHLEAPSEGTMDC 337
            F+  S+ ++ C+ G+ ++ P  + C         W    P C A  C      SEG +  
Sbjct: 1581 FKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCNA-PCGGQYTGSEGVVLS 1639

Query: 338  VHPLTAFAYGSSCKFEC----------QPGYRVRGL-DMLRCIDSGHWSAPLPTCEAISC 386
             +    +  G  C +            Q  Y    L D+    D  H  A L        
Sbjct: 1640 PNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAELFDGTHAQARLL------- 1692

Query: 387  EPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQAL 446
                S + GS        A        F    G   RG   V            P     
Sbjct: 1693 ----SSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVY--------QAVPRTSDT 1740

Query: 447  QCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGN----WNSVP 502
            QC  +P P   R   S     F   S+  F CN G LL G++ L C +  N    WN   
Sbjct: 1741 QCSSVPEPRYGRRIGSE----FSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTI 1796

Query: 503  PECQAIPCTPLLSPQNGTMTC---VQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR 559
            P C  +PC+   + + GT+      +P G ++     + I  EG  +   + +       
Sbjct: 1797 PSC-VVPCSGNFTQRRGTILSPGYPEPYG-NNLNCIWKIIVTEGSGIQ-IQVISFATEQN 1853

Query: 560  WTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGST---CHFSCDNGFKLEGPNNVEC 616
            W       E     ++ AP  GS   +      N  S     HF  D      G  ++E 
Sbjct: 1854 WDS----LEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAG-FHLEY 1908

Query: 617  TTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGF 676
             T G  +   P      +LP+  ++         G  Y          N    F C  G+
Sbjct: 1909 KTVGLAACQEP------ALPSNSIKI--------GDRYM--------VNDVLSFQCEPGY 1946

Query: 677  TLIGDSTLSCRPS--GQWTAVTPACRA 701
            TL G S +SC P    +W   +P C A
Sbjct: 1947 TLQGRSHISCMPGTVRRWNYPSPLCIA 1973



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 107/465 (23%), Positives = 162/465 (34%), Gaps = 86/465 (18%)

Query: 262 CPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKA 321
           C    IP  G  T      +F H  + +F C   F LVG  V+ C  +  W+   P C  
Sbjct: 528 CGDPGIPAYGKRT----GSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSC-V 582

Query: 322 VQCQHLEAPSEGTMDCVHPLTAFAYGSSCK----FECQPGYRVRGL----------DMLR 367
             C      S G +  + P     YG++         +PG R+  +          D L 
Sbjct: 583 FSCFFNFTASSGII--LSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLA 640

Query: 368 CIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADI 427
             D G           IS   +     G+ +    L +  +     F+       RG +I
Sbjct: 641 VKDDG-----------ISDITVLGTFSGN-EVPSQLASSGHIVRLEFQSDHSTTGRGFNI 688

Query: 428 VRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFG-AFRYQSVCSFTCNEGLLLV- 485
                 GQ           +C D  +P   R      FG  F   S  SF C++G +   
Sbjct: 689 TYT-TFGQ----------NECHDPGIPINGR-----RFGDRFLLGSSVSFHCDDGFVKTQ 732

Query: 486 GASVLQC-LATGN--WNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKST--CQFIC 540
           G+  + C L  GN  W+S  P C+A PC   L+  +G +  + P     YK +  C++I 
Sbjct: 733 GSESITCILQDGNVVWSSTVPRCEA-PCGGHLTASSGVI--LPPGWPGYYKDSLHCEWII 789

Query: 541 DEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHF 600
           +     S     D  ++    D+  +              G    S   GE++      F
Sbjct: 790 EAKPGHSIKITFDRFQTEVNYDTLEV------------RDGPASSSPLIGEYHGTQAPQF 837

Query: 601 SCDNG---FKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRH 657
               G   + L   +N   +          T +  + L  PG+       P  G      
Sbjct: 838 LISTGNFMYLLFTTDNSRSSIGFLIHYESVTLESDSCLD-PGI-------PVNG----HR 885

Query: 658 HPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAV 702
           H G FG  +T  F C+ G+TL  D  L C  + QW    P+C A+
Sbjct: 886 HGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDAL 930



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 90/434 (20%), Positives = 149/434 (34%), Gaps = 87/434 (20%)

Query: 342 TAFAYGSSCKFECQPGYRVRGLDMLRCIDS----GHWSAPLPTCEA-------------- 383
           T F  G   ++ C PGY + G  +L CI S      W  P P C A              
Sbjct: 159 TRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCRAEGACGGTLRGTSSS 218

Query: 384 ISCEPLESPVHGSMDCSPSLRAFQYDTNC----SFRCAEGFMLRGADIVRCDN--LGQWT 437
           IS     S    + DC+ ++ A   DT       F+  EG+           +  L    
Sbjct: 219 ISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYDFLEISGTEAPSIWLTGMN 278

Query: 438 APAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLV--GASVLQCLAT 495
            P+PV  +     L   +++    +H    F  Q    F   + + L   G  +L     
Sbjct: 279 LPSPVISSKNWLRLHFTSDS----NHRRKGFNAQ----FQVKKAIELKSRGVKMLPSKDG 330

Query: 496 GNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGS--SSYKSTCQFICDEGYSLSGPERLD 553
            + NSV  +   +     + P  G     +  GS  S   +  QF C++ Y L G + + 
Sbjct: 331 SHKNSVLSQ-GGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQFSCEDNYVLQGSKSIT 389

Query: 554 CTR----SGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTC----------- 598
           C R       W+D  P+C A  C        G +   +   ++   + C           
Sbjct: 390 CQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDK 449

Query: 599 -------HFSCDNGF---------KLEGPNNVECTTSGRWSATPPTCKGIA--------- 633
                   F  + G+         K+    +V    +G  S+ P     ++         
Sbjct: 450 VIKLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTG--SSVPDLIVSMSNQMWLHLQS 507

Query: 634 --SLPTPGVQC--PALTTPGQG----TMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLS 685
             S+ +PG +     +   G G      Y +    +F    T  F C A F L+G+  ++
Sbjct: 508 DDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVIT 567

Query: 686 CRPSGQWTAVTPAC 699
           C+ + QW+   P+C
Sbjct: 568 CQQNNQWSGNKPSC 581



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 119/583 (20%), Positives = 187/583 (32%), Gaps = 137/583 (23%)

Query: 290  FSCEEGFALVGPEVVQCTASG--VWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYG 347
            +SC  G+A+ G   + C +    VW  P P C A     + A + G +        +   
Sbjct: 1243 YSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIAECGGQIHAATSGRILSPGYPAPYDNN 1302

Query: 348  SSCKF--ECQPGYRVRGLDMLRCIDSGH-----WSAPLPT---CEAISCEPLESPVHGSM 397
              C +  E  PG  +    ++   +  H     W  P+ +    +  S   L   +H + 
Sbjct: 1303 LHCTWIIEADPGKTISLHFIVFDTEMAHDILKVWDGPVDSDILLKEWSGSALPEDIHSTF 1362

Query: 398  DCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVP-NE 456
            +        Q+D++  F    GF ++ +  +                A  C D  +P N 
Sbjct: 1363 NSL----TLQFDSDF-FISKSGFSIQFSTSI----------------AATCNDPGMPQNG 1401

Query: 457  ARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGN---WNSVPPECQAI----- 508
             R   S   G        +F C+ G  L G + + C+   N   W   PP C A      
Sbjct: 1402 TRYGDSREAG-----DTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACGGNL 1456

Query: 509  --PCTPLLSPQ-----------------NGTMTCVQPLGSSSYKSTCQFIC-----DEGY 544
              P   +LSP                  N          S + + +  F+      D   
Sbjct: 1457 TGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHIYEGEDSNS 1516

Query: 545  SLSG-------PERLDCTRSGRW----TDSPPMCEAIKCPELFAPEQGSLDCSDTRG--- 590
             L G       PER++ + +  +    +D+              P +   D  +      
Sbjct: 1517 PLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREACFDPGNIMNGTR 1576

Query: 591  ---EFNVGSTCHFSCDNGFKLEGPNNVECTTSG----RWSATPPTCKGIASLPTPGVQCP 643
               +F +GST  + CD+G+K+  P+++ C         W    P+C         G +  
Sbjct: 1577 VGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCNAPCGGQYTGSEGV 1636

Query: 644  ALT-------TPGQGTMYCRHHPGTF-GFNTTCYF------------GCNAGFTLIGD-- 681
             L+       T GQ  +Y    P  F  F    YF            G +A   L+    
Sbjct: 1637 VLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAELFDGTHAQARLLSSLS 1696

Query: 682  -----STLSCRPSGQWTAVTPACRAVKCSELH-----VNKPIAMNCSN---------LWG 722
                  TL    S Q      A         H     V +     CS+         +  
Sbjct: 1697 GSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAVPRTSDTQCSSVPEPRYGRRIGS 1756

Query: 723  NFSYGSICSFHCLEGQLLNGSAQTACQE----NGHWSTTVPTC 761
             FS GSI  F C  G LL GS    CQ        W+ T+P+C
Sbjct: 1757 EFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSC 1799



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 60/285 (21%), Positives = 101/285 (35%), Gaps = 53/285 (18%)

Query: 200 CGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLAS----GIWTNKPP 255
           CG    P  +L    H    F+   +  + C  GY + G + L C+ S      W    P
Sbjct: 145 CGN---PGEILKGVLHGT-RFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAP 200

Query: 256 QCLA-AQCPPLKIPERGNMTCLHSAKAFQHQSSCS-----------------FSCEEGFA 297
            C A   C         +++  H    +++ + C+                 F  EEG+ 
Sbjct: 201 FCRAEGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYD 260

Query: 298 LVGPEVVQCTASGVW----TAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFE 353
            +  E+    A  +W      P+PV  +     L      T D  H    F    + +F+
Sbjct: 261 FL--EISGTEAPSIWLTGMNLPSPVISSKNWLRLHF----TSDSNHRRKGF----NAQFQ 310

Query: 354 CQPGYRV--RGLDMLRCIDSGHWSAPLP----TCEAISCEPLESPVHGSMDCSPSLRAFQ 407
            +    +  RG+ ML   D  H ++ L        +  C     P +G    S   R   
Sbjct: 311 VKKAIELKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRV-- 368

Query: 408 YDTNCSFRCAEGFMLRGADIVRC----DNLGQWTAPAPVCQALQC 448
              N  F C + ++L+G+  + C    + L  W+   P+C+A  C
Sbjct: 369 -GANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTC 412



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 32/84 (38%), Positives = 41/84 (48%), Gaps = 12/84 (14%)

Query: 444  QALQCQDLPVP----NEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCL--ATGN 497
            QA + Q+ P P    N   +N  +  G    QSV SF C  G +L+G  VL C      N
Sbjct: 2081 QAYELQNCPDPPPFQNGYMINSDYSVG----QSV-SFECYPGYILIGHPVLTCQHGINRN 2135

Query: 498  WNSVPPECQAIPCTPLLSPQNGTM 521
            WN   P C A PC   ++ QNGT+
Sbjct: 2136 WNYPFPRCDA-PCGYNVTSQNGTI 2158



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 49/240 (20%), Positives = 72/240 (30%), Gaps = 65/240 (27%)

Query: 262 CPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQC----TASGVWTAPAP 317
           CP   IPE G       ++     ++  FSCE+ + L G + + C         W+   P
Sbjct: 349 CPDPGIPENGRRAGSDFSRV---GANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRP 405

Query: 318 VCKAVQC-QHLEAPS------------EGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLD 364
           +C+A  C  +L  PS            E    CV  +T        K   +     RG D
Sbjct: 406 ICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYD 465

Query: 365 MLRCIDSGH-----------------------------------------WSAPLPTCEA 383
            L   D+G                                          + A     E 
Sbjct: 466 TLTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEK 525

Query: 384 ISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC 443
             C     P +G    S    +F +    +F C   F L G  ++ C    QW+   P C
Sbjct: 526 GGCGDPGIPAYGKRTGS----SFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSC 581



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 95/449 (21%), Positives = 160/449 (35%), Gaps = 77/449 (17%)

Query: 282  FQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPS---------- 331
            F  +S+ +FSC+ G+ L   E + C  +  W    P C A+   +++  S          
Sbjct: 890  FGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALCGGYIQGKSGTVLSPGFPD 949

Query: 332  --EGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCE-AISCEP 388
                +++C   +   ++G   +      +     D L   + G +S P+     ++    
Sbjct: 950  FYPNSLNCTWTIEV-SHGKGVQMIFHTFHLESSHDYLLITEDGSFSEPVARLTGSVLPHT 1008

Query: 389  LESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGA--DIVRCDNLGQWTAPAPVCQAL 446
            +++ + G+   +  LR F  D + S+   EGF +  +  D+  CD+ G            
Sbjct: 1009 IKAGLFGNF--TAQLR-FISDFSISY---EGFNITFSEYDLEPCDDPG------------ 1050

Query: 447  QCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGN--WNSVPPE 504
                  VP  +R    H    F      +F+C  G  L GA+ L CL  G   W++  P 
Sbjct: 1051 ------VPAFSRRIGFH----FGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPR 1100

Query: 505  CQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSP 564
            C A  C   +    GT+  + P   S+Y +  + I    Y +        T +G+     
Sbjct: 1101 CVA-ECGASVKGNEGTL--LSPNFPSNYDNNHECI----YKIE-------TEAGKGIHLR 1146

Query: 565  PMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHF---SCDNGFKLEGPNNVECTTSGR 621
                 +   +      G    S   G F           S  N   LE   N   T  G 
Sbjct: 1147 TRSFQLFEGDTLKVYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQG- 1205

Query: 622  WSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGD 681
                  T   +     PG+       P  G  Y     G F  +T   + CN G+ + G 
Sbjct: 1206 -FQLTYTSFDLVKCEDPGI-------PNYG--YRIRDEGHF-TDTVVLYSCNPGYAMHGS 1254

Query: 682  STLSCRPSGQ--WTAVTPACRAVKCSELH 708
            +TL+C    +  W    P+C A    ++H
Sbjct: 1255 NTLTCLSGDRRVWDKPLPSCIAECGGQIH 1283



 Score = 37.4 bits (85), Expect = 0.058
 Identities = 32/123 (26%), Positives = 53/123 (43%), Gaps = 11/123 (8%)

Query: 175  LETIGNYTCSCYPGFYGPECEYVRE-CGELELPQHVLMNCSHPLG-NFSFNSQCSFHCTD 232
            L  I +++ S Y GF     EY  E C +  +P       S  +G +F      +F C  
Sbjct: 1021 LRFISDFSIS-YEGFNITFSEYDLEPCDDPGVPAF-----SRRIGFHFGVGDSLTFSCFL 1074

Query: 233  GYQVNGPSKLECLASG--IWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSF 290
            GY++ G +KL CL  G  +W+   P+C+ A+C        G +   +    + +   C +
Sbjct: 1075 GYRLEGATKLTCLGGGRRVWSAPLPRCV-AECGASVKGNEGTLLSPNFPSNYDNNHECIY 1133

Query: 291  SCE 293
              E
Sbjct: 1134 KIE 1136



 Score = 37.4 bits (85), Expect = 0.058
 Identities = 43/210 (20%), Positives = 73/210 (34%), Gaps = 53/210 (25%)

Query: 227  SFHCTDGYQVNGPSKLECLASG---IWTNKPPQCLAA-------------------QCPP 264
            +F C  GYQ+ G +K+ C+       W   PP C+AA                     PP
Sbjct: 1415 TFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACGGNLTGPAGVILSPNYPQPYPP 1474

Query: 265  LK-----IPERGNMTCLHSAKAFQHQSSCSF-----SCEEGFALVG-------PEVVQCT 307
             K     +    +       K+F  + S  F       +    L+G       PE ++ +
Sbjct: 1475 GKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHIYEGEDSNSPLIGSYQGSQAPERIESS 1534

Query: 308  ASGVWTA----PAPVCKAVQCQHLEAPSEGTMDCVHPL------TAFAYGSSCKFECQPG 357
             + ++ A     +        +  E P E   D  + +      T F  GS+  ++C  G
Sbjct: 1535 GNSLFLAFRSDASVGLSGFAIEFKEKPREACFDPGNIMNGTRVGTDFKLGSTITYQCDSG 1594

Query: 358  YRVRGLDMLRCI----DSGHWSAPLPTCEA 383
            Y++     + C+        W   LP+C A
Sbjct: 1595 YKILDPSSITCVIGADGKPSWDQVLPSCNA 1624



 Score = 37.4 bits (85), Expect = 0.058
 Identities = 18/42 (42%), Positives = 23/42 (54%), Gaps = 2/42 (4%)

Query: 344  FAYGSSCKFECQPGYRVRGLDMLRCIDSG--HWSAPLPTCEA 383
            F  G   K++C PGY + G D+L C  S    +   LPTCEA
Sbjct: 2277 FEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEA 2318



 Score = 37.0 bits (84), Expect = 0.075
 Identities = 55/274 (20%), Positives = 90/274 (32%), Gaps = 45/274 (16%)

Query: 387 EPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRC----DNLGQWTAPAPV 442
           E L+  +HG+         F       + C  G++L G  I+ C     N   W  PAP 
Sbjct: 150 EILKGVLHGTR--------FNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPF 201

Query: 443 CQAL-QCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSV 501
           C+A   C        + ++  H    +   + C++T    +L      +  + T      
Sbjct: 202 CRAEGACGGTLRGTSSSISSPHFPSEYENNADCTWT----ILAEPGDTIALVFTDFQLEE 257

Query: 502 PPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSG------------- 548
             +   I  T   S     M    P+ SS       F  D  +   G             
Sbjct: 258 GYDFLEISGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIEL 317

Query: 549 --------PERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHF 600
                   P +    ++   +       +  CP+   PE G    SD      VG+   F
Sbjct: 318 KSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFS---RVGANVQF 374

Query: 601 SCDNGFKLEGPNNVEC----TTSGRWSATPPTCK 630
           SC++ + L+G  ++ C     T   WS   P C+
Sbjct: 375 SCEDNYVLQGSKSITCQRVTETLAAWSDHRPICR 408



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 16/42 (38%), Positives = 24/42 (57%), Gaps = 2/42 (4%)

Query: 344  FAYGSSCKFECQPGYRVRGLDMLRCID--SGHWSAPLPTCEA 383
            ++ G S  FEC PGY + G  +L C    + +W+ P P C+A
Sbjct: 2104 YSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDA 2145



 Score = 35.4 bits (80), Expect = 0.22
 Identities = 96/467 (20%), Positives = 155/467 (33%), Gaps = 69/467 (14%)

Query: 258  LAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASG---VWTA 314
            +AA C    +P+ G         + +   + +F C+ G+ L G   + C        W  
Sbjct: 1388 IAATCNDPGMPQNGT----RYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQP 1443

Query: 315  PAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSC--KFECQPGYRVRGLDMLRCIDSG 372
              P C A    +L  P+   +   +P   +  G  C  + +  P + +  +       S 
Sbjct: 1444 DPPTCIAACGGNLTGPAGVILSPNYP-QPYPPGKECDWRVKVNPDFVIALI-----FKSF 1497

Query: 373  HWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNC---SFRCAEGFMLRGADIVR 429
            +             E   SP+ GS   S +    +   N    +FR      L G  I  
Sbjct: 1498 NMEPSYDFLHIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEF 1557

Query: 430  CDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASV 489
             +       P   C         + N  RV        F+  S  ++ C+ G  ++  S 
Sbjct: 1558 KEK------PREAC----FDPGNIMNGTRVGTD-----FKLGSTITYQCDSGYKILDPSS 1602

Query: 490  LQCL--ATG--NWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYS 545
            + C+  A G  +W+ V P C A PC    +   G +  + P    +Y  T   IC   YS
Sbjct: 1603 ITCVIGADGKPSWDQVLPSCNA-PCGGQYTGSEGVV--LSPNYPHNY--TAGQICL--YS 1655

Query: 546  LSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNG 605
            ++ P+       G++         +   ELF           +    + G T   +  N 
Sbjct: 1656 ITVPKEF--VVFGQFAYFQTALNDLA--ELFDGTHAQARLLSSLSGSHSGETLPLATSNQ 1711

Query: 606  FKLEGPNNVECTTSGR---WSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTF 662
              L        +  G    + A P T            QC ++  P  G    R     F
Sbjct: 1712 ILLRFSAKSGASARGFHFVYQAVPRTSD---------TQCSSVPEPRYG----RRIGSEF 1758

Query: 663  GFNTTCYFGCNAGFTLIGDSTLSCR----PSGQWTAVTPACRAVKCS 705
               +   F CN G+ L G + L C+       QW    P+C  V CS
Sbjct: 1759 SAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSC-VVPCS 1804



 Score = 33.9 bits (76), Expect = 0.64
 Identities = 21/55 (38%), Positives = 26/55 (47%), Gaps = 4/55 (7%)

Query: 713 IAMNCSNLWGNFSYGSICSFHCLEGQL-LNGSAQTAC---QENGHWSTTVPTCQA 763
           I +N       F  GS  SFHC +G +   GS    C     N  WS+TVP C+A
Sbjct: 703 IPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEA 757



 Score = 33.5 bits (75), Expect = 0.83
 Identities = 15/51 (29%), Positives = 23/51 (45%)

Query: 713 IAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQA 763
           I +N     G+F   S  +F C  G  L+      C+ N  W+  +P+C A
Sbjct: 879 IPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDA 929



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 75/333 (22%), Positives = 99/333 (29%), Gaps = 79/333 (23%)

Query: 255  PQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQC----TASG 310
            P+    QC  +  P  G          F   S   F C  G+ L G   + C     A  
Sbjct: 1735 PRTSDTQCSSVPEPRYGRRI----GSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALA 1790

Query: 311  VWTAPAPVCKAVQCQHLEAPSEGT-------------MDCVHPLTAFAYGSSCKFECQPG 357
             W    P C  V C        GT             ++C+  +     GS  + +    
Sbjct: 1791 QWNDTIPSC-VVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIV-TEGSGIQIQVISF 1848

Query: 358  YRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCA 417
               +  D L   D G  +AP       S      P   +   +     FQ D + +   A
Sbjct: 1849 ATEQNWDSLEIHDGGDVTAP----RLGSFSGTTVPALLNSTSNQLYLHFQSDISVA---A 1901

Query: 418  EGFMLRGADIVRCDNLGQWTAPAPVCQ--ALQCQDLPVPNEARVNCSHPFGAFRYQSVCS 475
             GF           +L   T     CQ  AL    + + +   VN            V S
Sbjct: 1902 AGF-----------HLEYKTVGLAACQEPALPSNSIKIGDRYMVN-----------DVLS 1939

Query: 476  FTCNEGLLLVGASVLQCL--ATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYK 533
            F C  G  L G S + C+      WN   P C A  C   LS   G              
Sbjct: 1940 FQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIA-TCGGTLSTLGGV------------- 1985

Query: 534  STCQFICDEGYSLSGPERLDCTRSGRWTDSPPM 566
                 I   G+  S P  LDCT    W  S P+
Sbjct: 1986 -----ILSPGFPGSYPNNLDCT----WRISLPI 2009



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 99/466 (21%), Positives = 152/466 (32%), Gaps = 76/466 (16%)

Query: 218  GNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLH 277
            G+F   S  +F C  GY ++    L C  +  W +  P C A                  
Sbjct: 888  GDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDAL----------------- 930

Query: 278  SAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQ----CQHLEAPSEG 333
                 Q +S    S   GF    P  + CT    WT      K VQ      HLE+  + 
Sbjct: 931  CGGYIQGKSGTVLS--PGFPDFYPNSLNCT----WTIEVSHGKGVQMIFHTFHLESSHDY 984

Query: 334  TM----DCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCID--SGHWSAPLPTCEAISCE 387
             +           A   GS      + G        LR I   S  +     T      E
Sbjct: 985  LLITEDGSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYDLE 1044

Query: 388  PLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ--WTAPAPVCQA 445
            P + P   +         F    + +F C  G+ L GA  + C   G+  W+AP P C A
Sbjct: 1045 PCDDPGVPAFSRRIGFH-FGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCVA 1103

Query: 446  LQCQDLPVPNEARVNCSHPFGAFRYQSVCSF----TCNEGLLLVGASVLQCLATGNWNSV 501
             +C      NE  +   +    +     C +       +G+ L   S    L  G+    
Sbjct: 1104 -ECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQ--LFEGD---- 1156

Query: 502  PPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWT 561
                        L   +G  +  +PLG+ +       I +   S S    L+   +G  T
Sbjct: 1157 -----------TLKVYDGKDSSSRPLGTFTKNELLGLILN---STSNHLWLEFNTNGSDT 1202

Query: 562  D-----SPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVEC 616
            D     +    + +KC +   P  G     +  G F   +   +SC+ G+ + G N + C
Sbjct: 1203 DQGFQLTYTSFDLVKCEDPGIPNYGYRIRDE--GHF-TDTVVLYSCNPGYAMHGSNTLTC 1259

Query: 617  TTSGR--WSATPPT----CKGIASLPTPG-VQCPALTTPGQGTMYC 655
             +  R  W    P+    C G     T G +  P    P    ++C
Sbjct: 1260 LSGDRRVWDKPLPSCIAECGGQIHAATSGRILSPGYPAPYDNNLHC 1305



 Score = 31.6 bits (70), Expect = 3.2
 Identities = 13/39 (33%), Positives = 18/39 (46%)

Query: 723 NFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
           +F +G   +F C     L G     CQ+N  WS   P+C
Sbjct: 543 SFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSC 581



 Score = 31.2 bits (69), Expect = 4.1
 Identities = 14/44 (31%), Positives = 23/44 (52%), Gaps = 4/44 (9%)

Query: 220 FSFNSQCSFHCTDGY-QVNGPSKLECL---ASGIWTNKPPQCLA 259
           F   S  SFHC DG+ +  G   + C+    + +W++  P+C A
Sbjct: 714 FLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEA 757



 Score = 31.2 bits (69), Expect = 4.1
 Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 8/63 (12%)

Query: 200  CGELELPQHVLMNCSHPLGN-FSFNSQCSFHCTDGYQVNGPSKLECLASGI--WTNKPPQ 256
            C E  LP +     S  +G+ +  N   SF C  GY + G S + C+   +  W    P 
Sbjct: 1916 CQEPALPSN-----SIKIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPL 1970

Query: 257  CLA 259
            C+A
Sbjct: 1971 CIA 1973


>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
            sapiens]
          Length = 3538

 Score =  242 bits (617), Expect = 1e-63
 Identities = 164/579 (28%), Positives = 241/579 (41%), Gaps = 59/579 (10%)

Query: 204  ELPQHVLMNCSHP--------LGN-FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKP 254
            +LP  V ++C HP         GN F+FN   +F C  GY + GP+K +C A+  W++ P
Sbjct: 2697 QLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPP 2756

Query: 255  PQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTA 314
            P C    C    IP             F + +   + C  G+ L G  V+ C  +G W  
Sbjct: 2757 PMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDK 2816

Query: 315  PAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHW 374
            P P C  + C H   P    +        + +GS+  + C     + G     C  +GHW
Sbjct: 2817 PLPECIMIDCGHPGVPPNAVLSG----EKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHW 2872

Query: 375  SAPLPTCEAIS---CEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCD 431
            S   P C   +   C    +P HGS   S     F+  +   + C  G++L G++   C 
Sbjct: 2873 SGSQPHCSGDATGTCGDPGTPGHGSRQESN----FRTKSTVRYACDTGYILHGSEERTCL 2928

Query: 432  NLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQ 491
              G WT   P C+A+QC +       +V          + S   ++C EG +L G SV Q
Sbjct: 2929 ANGSWTGRQPECKAVQCGNPGTTANGKV---FRIDGTTFSSSVIYSCMEGYILSGPSVRQ 2985

Query: 492  CLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYS--LSGP 549
            C A G W+   P C  I C     P NG    ++            ++C  GY+  L+G 
Sbjct: 2986 CTANGTWSGTLPNCTIISCGDPGIPANG----LRYGDDYVVGQNVSYMCQPGYTMELNGS 3041

Query: 550  ERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLE 609
                CT +G W+   P C A+ CP       G L+ ++    F+ G +  + C  G++L 
Sbjct: 3042 RIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN----FDWGFSISYICSPGYELS 3097

Query: 610  GPNNVECTTSGRWSATPPTCKGIASLPT----PGVQCPALTTPGQGTMYCRHHPGTFGFN 665
             P  + C  +G WS   P C     LP     PG+       P QG    +    +F + 
Sbjct: 3098 FPAVLTCVGNGTWSGEVPQC-----LPKFCGDPGI-------PAQG----KREGKSFIYQ 3141

Query: 666  TTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPAC---RAVKCSELHVNKPIAMNCSNLWG 722
            +   F CN  F L+G ST  C+  G W+  +P C       C    V +  + N  N +G
Sbjct: 3142 SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQN--NTFG 3199

Query: 723  NFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
             F  GS+  FHC +G LL GS    C  +  WS   P C
Sbjct: 3200 -FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPEC 3237



 Score =  194 bits (494), Expect = 2e-49
 Identities = 140/514 (27%), Positives = 216/514 (42%), Gaps = 40/514 (7%)

Query: 258  LAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASG----VWT 313
            +A  C   + P  G +    S    Q  S   ++C+ GF LVG     C  S      W 
Sbjct: 2461 IAFYCSTPESPPHGYII---SQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWD 2517

Query: 314  APAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLR--CIDS 371
            AP P C+A+ C   +AP+ G +      T +  G+   + C  GYR+   ++    C   
Sbjct: 2518 APVPACQAISCGIPKAPTNGGI----LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSD 2573

Query: 372  GHWSA--PLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVR 429
            G WS     P C  ISC  L +P +G+   + +     Y +   F C  GFML G+ +  
Sbjct: 2574 GTWSNHNKTPRCVVISCGELPTPPNGNKIGTQT----SYGSTAIFTCDLGFMLVGSAVRE 2629

Query: 430  CDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASV 489
            C + G W+     C A  C    +P E  VN       + Y+    + CN G  L+G+SV
Sbjct: 2630 CLSSGLWSESETRCLAGHCG---IP-ELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSV 2685

Query: 490  LQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGP 549
              C    NW+   P C  + C    SP  G  +        ++     F C+ GY + GP
Sbjct: 2686 RICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSG----NGFNFNDVVTFSCNIGYLMQGP 2741

Query: 550  ERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLE 609
             +  C  + +W+  PPMC+ + C +   P     +     G F  G+   + C+ G+ L 
Sbjct: 2742 TKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLF 2801

Query: 610  GPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCY 669
            G + + C  +G+W    P C  I     PGV   A+ +   G  Y      TFG  +T +
Sbjct: 2802 GSSVLICQPNGQWDKPLPECIMI-DCGHPGVPPNAVLS---GEKY------TFG--STVH 2849

Query: 670  FGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSI 729
            + C    +L+G S+ +C+ +G W+   P C          +     + S    NF   S 
Sbjct: 2850 YSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCG-DPGTPGHGSRQESNFRTKST 2908

Query: 730  CSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQA 763
              + C  G +L+GS +  C  NG W+   P C+A
Sbjct: 2909 VRYACDTGYILHGSEERTCLANGSWTGRQPECKA 2942



 Score =  163 bits (413), Expect = 5e-40
 Identities = 111/384 (28%), Positives = 165/384 (42%), Gaps = 28/384 (7%)

Query: 192  PECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWT 251
            PEC+ V +CG    P          +   +F+S   + C +GY ++GPS  +C A+G W+
Sbjct: 2938 PECKAV-QCGN---PGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWS 2993

Query: 252  NKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFA--LVGPEVVQCTAS 309
               P C    C    IP  G    L     +    + S+ C+ G+   L G  +  CT +
Sbjct: 2994 GTLPNCTIISCGDPGIPANG----LRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTIN 3049

Query: 310  GVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCI 369
            G W+   P C+AV C      S G ++     T F +G S  + C PGY +    +L C+
Sbjct: 3050 GTWSGVMPTCRAVTCPTPPQISNGRLEG----TNFDWGFSISYICSPGYELSFPAVLTCV 3105

Query: 370  DSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVR 429
             +G WS  +P C    C     P  G  +     ++F Y +  SF C   F+L G+    
Sbjct: 3106 GNGTWSGEVPQCLPKFCGDPGIPAQGKREG----KSFIYQSEVSFSCNFPFILVGSSTRI 3161

Query: 430  CDNLGQWTAPAPVC---QALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVG 486
            C   G W+  +P C       C++  VP     N  + FG F+  SV  F C +G LL G
Sbjct: 3162 CQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQN--NTFG-FQVGSVVQFHCKKGHLLQG 3218

Query: 487  ASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSL 546
            ++   CL    W+ + PEC    C     P+      V  +   S+  T  + C  G+ L
Sbjct: 3219 STTRTCLPDLTWSGIQPECIPHSCK---QPETPAHANVVGMDLPSHGYTLIYTCQPGFFL 3275

Query: 547  S-GPERLDCTRSGRWTDSPPMCEA 569
            + G E   C     WT   P+CEA
Sbjct: 3276 AGGTEHRVCRSDNTWTGKVPICEA 3299



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 62/245 (25%), Positives = 91/245 (37%), Gaps = 64/245 (26%)

Query: 219  NFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHS 278
            NF +    S+ C+ GY+++ P+ L C+ +G W+ + PQCL   C    IP +G       
Sbjct: 3079 NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGK----RE 3134

Query: 279  AKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVC---KAVQCQHLEAPSEG-- 333
             K+F +QS  SFSC   F LVG     C A G W+  +P C       C++   P  G  
Sbjct: 3135 GKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQ 3194

Query: 334  --------------------------TMDCVHPLTAF----------------------- 344
                                      T  C+  LT                         
Sbjct: 3195 NNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVV 3254

Query: 345  -----AYGSSCKFECQPGYRVRGLDMLR-CIDSGHWSAPLPTCEAISCEPLESPVHGSMD 398
                 ++G +  + CQPG+ + G    R C     W+  +P CEA S   ++ P      
Sbjct: 3255 GMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGT 3314

Query: 399  CSPSL 403
             SP L
Sbjct: 3315 PSPKL 3319



 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 67/216 (31%), Positives = 89/216 (41%), Gaps = 35/216 (16%)

Query: 569  AIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSG----RWSA 624
            A  C    +P  G +  S T G+ N  S   ++CD GF+L G ++  C  S      W A
Sbjct: 2462 AFYCSTPESPPHGYI-ISQTGGQLN--SVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDA 2518

Query: 625  TPPTCK----GIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIG 680
              P C+    GI   PT G           G +   +  GT       YF CN G+ L  
Sbjct: 2519 PVPACQAISCGIPKAPTNG-----------GILTTDYLVGT----RVTYF-CNDGYRLSS 2562

Query: 681  D--STLSCRPSGQWTA--VTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLE 736
               +T  C+  G W+    TP C  + C EL    P   N + +    SYGS   F C  
Sbjct: 2563 KELTTAVCQSDGTWSNHNKTPRCVVISCGEL----PTPPNGNKIGTQTSYGSTAIFTCDL 2618

Query: 737  GQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEAL 772
            G +L GSA   C  +G WS +   C AG   I E +
Sbjct: 2619 GFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELI 2654



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 111/485 (22%), Positives = 171/485 (35%), Gaps = 123/485 (25%)

Query: 261  QCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALV-GPEVVQCTASG---VWTAPA 316
            +CP   IP    +        FQ  SS S  CEEGF    G E + C       +W+   
Sbjct: 729  ECPDPGIP----INARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLI 784

Query: 317  PVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKF--ECQPGYRVR----------GLD 364
            P C A    H  APS   +    P   +    +C++  E +PG+ ++            D
Sbjct: 785  PKCGAPCGGHFSAPSGVILSPGWP-GYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYD 843

Query: 365  MLRCIDSGHWSAPL-----------------------------------------PTCEA 383
            +L   D  +  +PL                                          T   
Sbjct: 844  VLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNT 903

Query: 384  ISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC 443
             SC     PVHG          F   +  SF C  G+ L   + + C+    W+ P P C
Sbjct: 904  YSCLDPGIPVHGRRYGHD----FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 959

Query: 444  QALQCQDLPVPNEARVNCSHPFGAFRYQSV-CSFTCNEGLLLVGASVLQCLATGNWNSVP 502
             AL   D+  P+   ++  +P   F   S+ C++T +   +  G  V       N+++  
Sbjct: 960  DALCGGDVRGPSGTILSPGYP--EFYPNSLNCTWTVD---VTHGKGV-----QFNFHTFH 1009

Query: 503  PECQAIPCTPLLSPQNGTMTCVQPLGS---------------SSYKSTCQFICDEGYSLS 547
             E        LL  +NG+ T  QPL                  ++++  +FI D   S  
Sbjct: 1010 LEDHH---DYLLITENGSFT--QPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYE 1064

Query: 548  GPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFK 607
            G    + T S  +   P       C +   P+ GS         F +G T  FSC +G++
Sbjct: 1065 G---FNITFS-EYNLEP-------CEDPGIPQYGSR----IGFNFGIGDTLTFSCSSGYR 1109

Query: 608  LEGPNNVECTTSGR--WSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFN 665
            LEG + + C   GR  WSA  P C           +C A  T  +G +   ++P  +  N
Sbjct: 1110 LEGTSEIICLGGGRRVWSAPLPRCV---------AECGASATNNEGILLSPNYPLNYENN 1160

Query: 666  TTCYF 670
              C +
Sbjct: 1161 HECIY 1165



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 106/456 (23%), Positives = 169/456 (37%), Gaps = 87/456 (19%)

Query: 175  LETIGNYTCSCYPGFYGPECEYVRE-CGELELPQHVLMNCSHPLG-NFSFNSQCSFHCTD 232
            L  I +++ S Y GF     EY  E C +  +PQ+        +G NF      +F C+ 
Sbjct: 1053 LRFISDFSIS-YEGFNITFSEYNLEPCEDPGIPQY-----GSRIGFNFGIGDTLTFSCSS 1106

Query: 233  GYQVNGPSKLECLASG--IWTNKPPQCLAAQC-------------PPLKIPERGNMTCLH 277
            GY++ G S++ CL  G  +W+   P+C+A +C             P   +    N  C++
Sbjct: 1107 GYRLEGTSEIICLGGGRRVWSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENNHECIY 1165

Query: 278  SAKAFQHQ----SSCSFSCEEGFALVGPEVVQCTAS--GVWTAPAPVCKAVQCQ------ 325
            S +    +    S+ +F   +G  L   +    T    G +T  +     +         
Sbjct: 1166 SIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWL 1225

Query: 326  HLEAPSEGTMD-------------CVHP-LTAFAY---------GSSCKFECQPGYRVRG 362
               + +EGT +             C  P +  F Y         GS+  + C PGY + G
Sbjct: 1226 EFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHG 1285

Query: 363  LDMLRCI--DSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGF 420
              +L+C+  +   W  PLP+C A      +    G +  SP    F YD N   RC    
Sbjct: 1286 SSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRI-LSPGY-PFPYDNN--LRCMWMI 1341

Query: 421  MLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARV----NCSHPFGAFRYQSVCSF 476
             +   +IV    L   T  +     L+  D P  N+  +        P G     ++ + 
Sbjct: 1342 EVDPGNIVSLQFLAFDTEASH--DILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTI 1399

Query: 477  TCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTC 536
              +    +  +      A    +SV   C+  P  P+   +NG               T 
Sbjct: 1400 QFDTDFYISKSG----FAIQFSSSVATACRD-PGVPMNGTRNG--------DGREPGDTV 1446

Query: 537  QFICDEGYSLSGPERLDCTRSGR---WTDSPPMCEA 569
             F CD GY L G ER+ C +      W  SPP+C A
Sbjct: 1447 VFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA 1482



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 110/515 (21%), Positives = 174/515 (33%), Gaps = 85/515 (16%)

Query: 186  YPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECL 245
            Y GF+    EY  +  E       +MN +    ++   S  +++C  GY + G S L C+
Sbjct: 1582 YTGFH---LEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCI 1638

Query: 246  ASGI----WTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCE--EGFALV 299
                    W    P C  A C        G +   +  K +    +C +S    + F + 
Sbjct: 1639 MGDDGRPGWNRALPSC-HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVF 1697

Query: 300  GPEVVQCTA--SGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPG 357
            G  V   T+    V     P  ++     L     G      PL++     + +F     
Sbjct: 1698 GQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGES---LPLSS-GNQITIRFTSVGP 1753

Query: 358  YRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCA 417
               +G   +           +P   +  C  +  P  G    +     F   ++  F C 
Sbjct: 1754 ITAKGFHFVY--------QAVPRTSSTQCSSVPEPRFGRRIGNE----FAVGSSVLFDCN 1801

Query: 418  EGFMLRGADIVRCD----NLGQWTAPAPVCQALQCQDL-------------PVPNEARVN 460
             G++L G+  +RC+    +L QW    P C  + C  +             P P +  +N
Sbjct: 1802 PGYILHGSIAIRCETVPNSLAQWNDSLPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLN 1860

Query: 461  CSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGT 520
            C           V   T  EG   +   V+      NW+S+          P L   +GT
Sbjct: 1861 C-----------VWKITVPEGAG-IQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGT 1908

Query: 521  MTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQ 580
             T    L S+S      F  D   S +G   L+ T  G   DS        CPE   P  
Sbjct: 1909 -TIPHLLNSTSNNLYLNFQSDISVSAAG-FHLEYTAIG--LDS--------CPEPQTPSS 1956

Query: 581  GSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTS--GRWSATPPTCKGIASLPTP 638
            G +   D    + VG    F CD G+ L+G +++ C      RW+   P C         
Sbjct: 1957 G-IKIGD---RYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICL-------- 2004

Query: 639  GVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCN 673
              QC    +   G +     PG +  +  C +  N
Sbjct: 2005 -AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTIN 2038



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 121/600 (20%), Positives = 189/600 (31%), Gaps = 168/600 (28%)

Query: 228  FHCTDGYQVNGPSKLECLASG---IWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQH 284
            F C  GY++ G  ++ C+       W   PP C+A  C        G +   +    + H
Sbjct: 1448 FQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAP-CGGNLTGSSGFILSPNFPHPYPH 1506

Query: 285  QSSC-----------------SFSCEEGFALV----GPEVVQCTASGVWTAPAP--VCKA 321
               C                 SFS E  +  +    GP+           +  P  +  +
Sbjct: 1507 SRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESS 1566

Query: 322  VQCQHLEAPSEGTMD---------------CVHPLTA---------FAYGSSCKFECQPG 357
                HL   S+G++                C  P            +  GS+  + C  G
Sbjct: 1567 SNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAG 1626

Query: 358  YRVRGLDMLRCI--DSGH--WSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCS 413
            Y ++G   L CI  D G   W+  LP+C A  C    +   G++      + +    NC 
Sbjct: 1627 YVLQGYSTLTCIMGDDGRPGWNRALPSCHA-PCGSRSTGSEGTVLSPNYPKNYSVGHNCV 1685

Query: 414  FRCA--EGFMLRGADI-------------------------------------------- 427
            +  A  + F++ G  +                                            
Sbjct: 1686 YSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQIT 1745

Query: 428  VRCDNLGQWTAPA--------PVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCN 479
            +R  ++G  TA          P   + QC  +P P   R         F   S   F CN
Sbjct: 1746 IRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGR----RIGNEFAVGSSVLFDCN 1801

Query: 480  EGLLLVGASVLQCLATGN----WNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKST 535
             G +L G+  ++C    N    WN   P C  +PC  +L+ + GT               
Sbjct: 1802 PGYILHGSIAIRCETVPNSLAQWNDSLPTC-IVPCGGILTKRKGT--------------- 1845

Query: 536  CQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPEL-FAPEQG--SLDCSD----- 587
               I   GY       L+C     W  + P    I+   + FA E    SLD  D     
Sbjct: 1846 ---ILSPGYPEPYDNNLNCV----WKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNN 1898

Query: 588  --TRGEFNVGSTCHF--SCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCP 643
                G ++  +  H   S  N   L   +++  + +G       T  G+ S P P     
Sbjct: 1899 APRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAG--FHLEYTAIGLDSCPEP----- 1951

Query: 644  ALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPS--GQWTAVTPACRA 701
               TP  G          +       F C+ G++L G S ++C P    +W    P C A
Sbjct: 1952 --QTPSSGIKI----GDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLA 2005



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 91/450 (20%), Positives = 161/450 (35%), Gaps = 80/450 (17%)

Query: 276 LHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTM 335
           +     F ++    F C+ GF L+G + + C  +  W+A  P+C      +  AP    +
Sbjct: 570 IREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVL 629

Query: 336 DCVHPLTAFAYGSSCKFEC--QPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPV 393
              +P   +    +C +     PG R+         +     +          +  ESP+
Sbjct: 630 SPDYP-EGYGNNLNCIWTIISDPGSRIH-----LSFNDFDLESQFDFLAVKDGDSPESPI 683

Query: 394 HGSM---DCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQD 450
            G+    +    L +  +     F+       RG +I   +  G            +C D
Sbjct: 684 LGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITY-NTFGH----------NECPD 732

Query: 451 LPVPNEARVNCSHPFGA-FRYQSVCSFTCNEGLLLV-GASVLQCLATGN---WNSVPPEC 505
             +P  AR      FG  F+  S  S  C EG +   G   + C+       W+ + P+C
Sbjct: 733 PGIPINAR-----RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 787

Query: 506 QAIPCTPLLSPQNGTMTCVQPLGSSSYKST--CQFI--CDEGYSLSGP-ERLDCTRSGRW 560
            A PC    S  +G +  + P     YK +  C+++   + G+S+    ER     +   
Sbjct: 788 GA-PCGGHFSAPSGVI--LSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNY-- 842

Query: 561 TDSPPMCEAIKCPELFAPEQGSLD--------CSDTRGEFNVGSTCHFSCDNGFKLEGPN 612
                + E    P L +P  GS +         S +   + + +T +   +NGFK+    
Sbjct: 843 ----DVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKI---- 894

Query: 613 NVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGC 672
           + E  T   +S   P       +P  G                R +   F   +T  F C
Sbjct: 895 HYESVTVNTYSCLDP------GIPVHG----------------RRYGHDFSIGSTVSFSC 932

Query: 673 NAGFTLIGDSTLSCRPSGQWTAVTPACRAV 702
           ++G+ L  +  L C  +  W+   P C A+
Sbjct: 933 DSGYRLSHEEPLLCEKNHWWSHPLPTCDAL 962



 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 96/440 (21%), Positives = 160/440 (36%), Gaps = 73/440 (16%)

Query: 282  FQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHP- 340
            F   S+ SFSC+ G+ L   E + C  +  W+ P P C A+    +  PS   +   +P 
Sbjct: 922  FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPE 981

Query: 341  ----------LTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEP-L 389
                           +G   +F     +     D L   ++G ++ PL         P +
Sbjct: 982  FYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTI 1041

Query: 390  ESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQ 449
             + ++G+      LR F  D + S+   EGF +  ++     NL              C+
Sbjct: 1042 NAGLYGNFRAQ--LR-FISDFSISY---EGFNITFSEY----NLEP------------CE 1079

Query: 450  DLPVPNE-ARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGN--WNSVPPECQ 506
            D  +P   +R+  +   G        +F+C+ G  L G S + CL  G   W++  P C 
Sbjct: 1080 DPGIPQYGSRIGFNFGIG-----DTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1134

Query: 507  AIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPM 566
            A  C    +   G +  + P    +Y++  + I    YS+         ++G+  +    
Sbjct: 1135 A-ECGASATNNEGIL--LSPNYPLNYENNHECI----YSIQ-------VQAGKGINISAR 1180

Query: 567  CEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHF---SCDNGFKLEGPNNVECTTSGRWS 623
               +   ++     G    +   G F   S       S  N   LE  ++ E T  G   
Sbjct: 1181 TFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQL 1240

Query: 624  ATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDST 683
                T   ++    PG+         QG     H  G+     T  +GCN G+TL G S 
Sbjct: 1241 VY--TSFELSHCEDPGIPQFGYKISDQG-----HFAGS-----TIIYGCNPGYTLHGSSL 1288

Query: 684  LSCRPSGQ--WTAVTPACRA 701
            L C    +  W    P+C A
Sbjct: 1289 LKCMTGERRAWDYPLPSCIA 1308



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 60/287 (20%), Positives = 96/287 (33%), Gaps = 38/287 (13%)

Query: 342 TAFAYGSSCKFECQPGYRVRGLDMLRCI----DSGHWSAPLPTCEA-------------- 383
           T F  G   ++ C  GY + G   L CI    ++  W  P+P C A              
Sbjct: 192 TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGI 251

Query: 384 ISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDN-------LGQW 436
           IS     +  H + DC+ ++ A   DT  S    +  M    D +  +        L   
Sbjct: 252 ISSPSFPNEYHNNADCTWTIVAEPGDT-ISLIFTDFQMEEKYDYLEIEGSEPPTIWLSGM 310

Query: 437 TAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATG 496
             P P+        L    ++          ++ +    F      L  G       +  
Sbjct: 311 NIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKSRGFKLFPGKDNSNKFSIL 370

Query: 497 NWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSS-SYKSTCQFICDEGYSLSGPERLDCT 555
           N   +       P      P+NG     + +GS  S  ST QF CDE Y L G + + C 
Sbjct: 371 NEGGIKTASNLCPDPG--EPENG-----KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQ 423

Query: 556 RSGR----WTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTC 598
           R       W+D  P+C+   C        G+    +   +++  + C
Sbjct: 424 RIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQC 470



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 100/445 (22%), Positives = 153/445 (34%), Gaps = 86/445 (19%)

Query: 347  GSSCKFECQPGYRVRGLDMLRCIDSGH---WSAPLPTCEA------------ISCEPLES 391
            G +  F+C PGY ++G + + CI   +   W    P C A            I       
Sbjct: 1443 GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPH 1502

Query: 392  PVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAP---APVCQALQC 448
            P   S DC  ++       N  +  +  F+    +    D L  +  P   +P+  + Q 
Sbjct: 1503 PYPHSRDCDWTITV-----NADYVISLAFISFSIE-PNYDFLYIYDGPDSNSPLIGSFQD 1556

Query: 449  QDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQ--CLATGNWNSVPPECQ 506
              LP   E+  N  H   AFR     S+T   G  L   + L+  C   GN         
Sbjct: 1557 SKLPERIESSSNTMHL--AFRSDGSVSYT---GFHLEYKAKLRESCFDPGNI-------- 1603

Query: 507  AIPCTPLLSPQNGTMTCVQPLGSSSYK--STCQFICDEGYSLSGPERLDCTRS--GR--W 560
                       NGT           YK  ST  + CD GY L G   L C     GR  W
Sbjct: 1604 ----------MNGTRL------GMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGW 1647

Query: 561  TDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSG 620
              + P C A  C       +G++   +    ++VG  C +S      +  P   E    G
Sbjct: 1648 NRALPSCHA-PCGSRSTGSEGTVLSPNYPKNYSVGHNCVYS------IAVPK--EFVVFG 1698

Query: 621  RWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIG 680
            ++     +   +  +     Q  +L +   G+      P + G   T  F      T  G
Sbjct: 1699 QFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKG 1758

Query: 681  DSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLL 740
               +       + AV P   + +CS +    P       +   F+ GS   F C  G +L
Sbjct: 1759 FHFV-------YQAV-PRTSSTQCSSV----PEPRFGRRIGNEFAVGSSVLFDCNPGYIL 1806

Query: 741  NGSAQTACQ----ENGHWSTTVPTC 761
            +GS    C+        W+ ++PTC
Sbjct: 1807 HGSIAIRCETVPNSLAQWNDSLPTC 1831



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 51/217 (23%), Positives = 80/217 (36%), Gaps = 46/217 (21%)

Query: 591  EFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQ 650
            +F++GST  FSCD+G++L     + C  +  WS   PTC  +      G     L+ PG 
Sbjct: 921  DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILS-PGY 979

Query: 651  GTMY-----------CRHHPGT-FGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTA--VT 696
               Y             H  G  F F+T  +   +  + LI ++    +P  + T   + 
Sbjct: 980  PEFYPNSLNCTWTVDVTHGKGVQFNFHTF-HLEDHHDYLLITENGSFTQPLARLTGSDLP 1038

Query: 697  PACRA------------------------VKCSELHV----NKPIAMNCSNLWGNFSYGS 728
            P   A                        +  SE ++    +  I    S +  NF  G 
Sbjct: 1039 PTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGD 1098

Query: 729  ICSFHCLEGQLLNGSAQTACQENGH--WSTTVPTCQA 763
              +F C  G  L G+++  C   G   WS  +P C A
Sbjct: 1099 TLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA 1135



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 64/261 (24%), Positives = 98/261 (37%), Gaps = 47/261 (18%)

Query: 531  SYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPE----------- 579
            S  ST  F CD GY LS  E L C ++  W+   P C+A+   ++  P            
Sbjct: 923  SIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEF 982

Query: 580  -QGSLDCSDT------RG-EFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSAT--PPTC 629
               SL+C+ T      +G +FN   T H    + + L   N        R + +  PPT 
Sbjct: 983  YPNSLNCTWTVDVTHGKGVQFNF-HTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTI 1041

Query: 630  K----GIASLPTPGVQCPALTTPGQGTMYCRHH------PG----------TFGFNTTCY 669
                 G        +   +++  G    +  ++      PG           FG   T  
Sbjct: 1042 NAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLT 1101

Query: 670  FGCNAGFTLIGDSTLSCRPSGQ--WTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYG 727
            F C++G+ L G S + C   G+  W+A  P C A +C     N    +   N   N+   
Sbjct: 1102 FSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENN 1160

Query: 728  SIC--SFHCLEGQLLNGSAQT 746
              C  S     G+ +N SA+T
Sbjct: 1161 HECIYSIQVQAGKGINISART 1181



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 61/262 (23%), Positives = 96/262 (36%), Gaps = 53/262 (20%)

Query: 344 FAYGSSCKFECQPGYRVRGLDMLRCIDSGH----WSAPLPTCEAISC-EPLESPVHGSMD 398
           F+ GS+ +F C   Y ++G   + C         WS   P C+  +C   L+ P      
Sbjct: 398 FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGP--SGTF 455

Query: 399 CSPSLRAFQYDTNCSFRCA----------------EGFMLR-GADIVRCDNLGQWTAPAP 441
            SP+   FQYD+N   +C                 E F L  G D +   + G+   P  
Sbjct: 456 TSPNF-PFQYDSNA--QCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRT 512

Query: 442 VCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSV 501
           V Q L    +P   +  V+ S        Q       +E +  VG  V       N+  +
Sbjct: 513 VLQVLTGSFVP---DLIVSMSS-------QMWLHLQTDESVGSVGFKV-------NYKEI 555

Query: 502 PPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWT 561
             E    P TPL   + G           S +   +F C  G+ L G + + C  + +W+
Sbjct: 556 EKESCGDPGTPLYGIREGD--------GFSNRDVLRFECQFGFELIGEKSIVCQENNQWS 607

Query: 562 DSPPMCEAIKCPELFAPEQGSL 583
            + P+C    C   F    G++
Sbjct: 608 ANIPIC-IFPCLSNFTAPMGTV 628



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 53/240 (22%), Positives = 74/240 (30%), Gaps = 66/240 (27%)

Query: 262 CPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQC----TASGVWTAPAP 317
           CP    PE G          F   S+  FSC+E + L G + + C         W+   P
Sbjct: 382 CPDPGEPENGKRI----GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRP 437

Query: 318 VCKAVQC-QHLEAPS------------EGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLD 364
           VCK   C  +L+ PS            +    CV  +TA       +   +      G D
Sbjct: 438 VCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYD 497

Query: 365 MLRCIDSGHWSAP--------------------------LPTCEAI-------------- 384
            L   D G    P                          L T E++              
Sbjct: 498 TLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEK 557

Query: 385 -SCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC 443
            SC    +P++G  +       F       F C  GF L G   + C    QW+A  P+C
Sbjct: 558 ESCGDPGTPLYGIREGD----GFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 613



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 23/63 (36%), Positives = 30/63 (47%), Gaps = 8/63 (12%)

Query: 572 CPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVEC----TTSGRWSATPP 627
           CP+   PE G    SD    F++GST  FSCD  + L+G  ++ C         WS   P
Sbjct: 382 CPDPGEPENGKRIGSD----FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRP 437

Query: 628 TCK 630
            CK
Sbjct: 438 VCK 440



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 64/265 (24%), Positives = 95/265 (35%), Gaps = 28/265 (10%)

Query: 442  VCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCL--ATGNWN 499
            V QA Q Q  P P   R N       F      SF C  G  L+G S L CL   + NWN
Sbjct: 2111 VYQAYQLQSCPDPRPFR-NGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWN 2169

Query: 500  SVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR 559
               P C+A+ C   ++  NGT      + S  Y        D  + +  P       +  
Sbjct: 2170 HPLPRCEAL-CGGNITAMNGT------IYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFT 2222

Query: 560  WTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTS 619
               + P+ + I   +   P+Q S       G  N      +S  N   ++   + + TTS
Sbjct: 2223 VLQTEPIYDFITVWD--GPDQNSPQIGQFSG--NTALESVYSTSNQILIK--FHSDFTTS 2276

Query: 620  GRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLI 679
            G +  +    +     P P V    + T              F       + C  GFTL+
Sbjct: 2277 GFFVLSYHAYQLRVCQPPPPVPNAEILT----------EDDEFEIGDIIRYQCLPGFTLV 2326

Query: 680  GDSTLSCRPSG--QWTAVTPACRAV 702
            G++ L+CR     Q     P C+ +
Sbjct: 2327 GNAILTCRLGERLQMDGAPPVCQVL 2351



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 19/43 (44%), Positives = 25/43 (58%), Gaps = 2/43 (4%)

Query: 344  FAYGSSCKFECQPGYRVRGLDMLRCID--SGHWSAPLPTCEAI 384
            F  G +  FEC PGY + G   L C+   S +W+ PLP CEA+
Sbjct: 2136 FTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL 2178



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 101/443 (22%), Positives = 154/443 (34%), Gaps = 89/443 (20%)

Query: 219  NFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHS 278
            +FS  S  SF C  GY+++    L C  +  W++  P C A     ++ P    ++    
Sbjct: 921  DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILS---- 976

Query: 279  AKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQ----HLEAPSEGT 334
                            G+    P  + CT    WT      K VQ      HLE      
Sbjct: 977  ---------------PGYPEFYPNSLNCT----WTVDVTHGKGVQFNFHTFHLE------ 1011

Query: 335  MDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDS---GHWSAPLP------------ 379
             D    L     GS      QP  R+ G D+   I++   G++ A L             
Sbjct: 1012 -DHHDYLLITENGSF----TQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGF 1066

Query: 380  --TCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ-- 435
              T    + EP E P             F      +F C+ G+ L G   + C   G+  
Sbjct: 1067 NITFSEYNLEPCEDPGIPQYGSRIGFN-FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRV 1125

Query: 436  WTAPAPVCQALQCQDLPVPNEA-RVNCSHPFG-AFRYQSVCSFTCNEGLLLVGASVLQCL 493
            W+AP P C A +C      NE   ++ ++P      ++ + S     G  +  ++    L
Sbjct: 1126 WSAPLPRCVA-ECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL 1184

Query: 494  ATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFI-----CDEGYSLSG 548
            A G+   +         T LL    G       L S+S +   +F       DEG+ L  
Sbjct: 1185 AQGDVLKIYDGKD--KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVY 1242

Query: 549  PERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKL 608
                               E   C +   P+ G    SD +G F  GST  + C+ G+ L
Sbjct: 1243 TS----------------FELSHCEDPGIPQFG-YKISD-QGHF-AGSTIIYGCNPGYTL 1283

Query: 609  EGPNNVECTTSGR--WSATPPTC 629
             G + ++C T  R  W    P+C
Sbjct: 1284 HGSSLLKCMTGERRAWDYPLPSC 1306



 Score = 35.4 bits (80), Expect = 0.22
 Identities = 15/38 (39%), Positives = 17/38 (44%)

Query: 724 FSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
           FS   +  F C  G  L G     CQEN  WS  +P C
Sbjct: 576 FSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC 613



 Score = 35.0 bits (79), Expect = 0.29
 Identities = 46/223 (20%), Positives = 73/223 (32%), Gaps = 63/223 (28%)

Query: 595  GSTCHFSCDNGFKLEGPNNVECTTSGR---WSATPPTCKGIASLPTPGVQCPALTTPGQG 651
            G T  F CD G++L+G   + C        W  +PP C            C    T   G
Sbjct: 1443 GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI---------APCGGNLTGSSG 1493

Query: 652  TMYCRHHPGTFGFNTTC------------------------------YFGCNAGFTLIG- 680
             +   + P  +  +  C                              Y G ++   LIG 
Sbjct: 1494 FILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGS 1553

Query: 681  --DSTLSCRPSGQWTAVTPACRA--------------VKCSELHVNKPIAMNCSNLWGNF 724
              DS L  R       +  A R+               K  E   +    MN + L  ++
Sbjct: 1554 FQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDY 1613

Query: 725  SYGSICSFHCLEGQLLNGSAQTAC--QENGH--WSTTVPTCQA 763
              GS  +++C  G +L G +   C   ++G   W+  +P+C A
Sbjct: 1614 KLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA 1656



 Score = 30.4 bits (67), Expect = 7.0
 Identities = 18/46 (39%), Positives = 23/46 (50%), Gaps = 3/46 (6%)

Query: 217  LGN-FSFNSQCSFHCTDGYQVNGPSKLECL--ASGIWTNKPPQCLA 259
            +GN F+     SF C  GY + G S L CL   S  W +  P+C A
Sbjct: 2132 IGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEA 2177



 Score = 30.0 bits (66), Expect = 9.2
 Identities = 16/51 (31%), Positives = 21/51 (41%), Gaps = 4/51 (7%)

Query: 716 NCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGH----WSTTVPTCQ 762
           N   +  +FS GS   F C E  +L G+    CQ        WS   P C+
Sbjct: 390 NGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 440


>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
           isoform 1 [Homo sapiens]
          Length = 1092

 Score =  218 bits (556), Expect = 1e-56
 Identities = 175/619 (28%), Positives = 258/619 (41%), Gaps = 84/619 (13%)

Query: 192 PECEYVRE---CGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASG 248
           P+CEY  +   C E  +P    +  S P   +      +F C   + +NG   + C A+ 
Sbjct: 80  PKCEYFNKYSSCPEPIVPGGYKIRGSTP---YRHGDSVTFACKTNFSMNGNKSVWCQANN 136

Query: 249 IW-TNKPPQCLAA---QCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVV 304
           +W   + P C++    +CP L +   G+ T   +  +     S ++SCE G+ LVG +++
Sbjct: 137 MWGPTRLPTCVSVFPLECPALPMIHNGHHTS-ENVGSIAPGLSVTYSCESGYLLVGEKII 195

Query: 305 QCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLD 364
            C +SG W+A  P C+  +C+ L     G    V        G +  F C  GYR++G  
Sbjct: 196 NCLSSGKWSAVPPTCEEARCKSLGRFPNGK---VKEPPILRVGVTANFFCDEGYRLQGPP 252

Query: 365 MLRCIDSGHWSA--PLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRC----AE 418
             RC+ +G   A   +P CE I C P   P+        SL    Y +  ++ C     E
Sbjct: 253 SSRCVIAGQGVAWTKMPVCEEIFC-PSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEE 311

Query: 419 G--FMLRGADIVRC----DNLGQWTAPAPVCQ----ALQCQDLPVPNEARVN-CSHPFGA 467
           G  F+L G   +RC       G W+ PAP C+    A+QC   P P   R    S     
Sbjct: 312 GVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQC---PHPQILRGRMVSGQKDR 368

Query: 468 FRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPP----ECQAIPCTPLLSPQNGTMTC 523
           + Y     F C  G  L G+  ++C A G W    P    ECQA P   +L+ Q      
Sbjct: 369 YTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPP--NILNGQKEDRHM 426

Query: 524 VQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSL 583
           V+    +S K    + C+ GY L G E + CT  G WT   P C+   C        G  
Sbjct: 427 VRFDPGTSIK----YSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAAC-----EATGRQ 477

Query: 584 DCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCP 643
             +  + +F V    + SC  G+KL G    EC  +  W      CK I   P P     
Sbjct: 478 LLTKPQHQF-VRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPP----- 531

Query: 644 ALTTPGQGTMYCRHHPGT----FGFNTTCYFGCNAG------FTLIGDSTLSC----RPS 689
                    +Y   H G+    F + TT  + CN G      F+LIG+ST+ C    +  
Sbjct: 532 --------VIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQER 583

Query: 690 GQWTAVTPACR----AVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQ 745
           G W+   P C+    AV+CS +H+        S     + Y    +F C  G  L GS+Q
Sbjct: 584 GTWSGPAPLCKLSLLAVQCSHVHIAN--GYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQ 641

Query: 746 TACQENGHWSTTVPTCQAG 764
             C+ +  W   +P C+ G
Sbjct: 642 IRCKADNTWDPEIPVCEKG 660



 Score =  203 bits (516), Expect = 6e-52
 Identities = 166/595 (27%), Positives = 248/595 (41%), Gaps = 69/595 (11%)

Query: 214 SHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNM 273
           S  +G+ +     ++ C  GY + G   + CL+SG W+  PP C  A+C  L     G +
Sbjct: 167 SENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKV 226

Query: 274 TCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASG---VWTAPAPVCKAVQCQHLEAP 330
                    +   + +F C+EG+ L GP   +C  +G    WT   PVC+ + C     P
Sbjct: 227 K---EPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTK-MPVCEEIFCPS-PPP 281

Query: 331 SEGTMDCVHPLTAFAYGSSCKFECQP------GYRVRGLDMLRC-IDS---GHWSAPLPT 380
                   + L   +YGS   + C P       + + G   LRC +DS   G WS P P 
Sbjct: 282 ILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPR 341

Query: 381 CE----AISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQW 436
           CE    A+ C P    + G M      R + Y+    F C  GF L+G+  +RC+  G W
Sbjct: 342 CELSTSAVQC-PHPQILRGRMVSGQKDR-YTYNDTVIFACMFGFTLKGSKQIRCNAQGTW 399

Query: 437 TAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATG 496
              APVC+  +CQ  P     +    H    F   +   ++CN G +LVG   +QC + G
Sbjct: 400 EPSAPVCEK-ECQAPPNILNGQKEDRHMV-RFDPGTSIKYSCNPGYVLVGEESIQCTSEG 457

Query: 497 NWNSVPPECQAIPCTP-----LLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPER 551
            W    P+C+   C       L  PQ+     V+P  +SS        C EGY LSG   
Sbjct: 458 VWTPPVPQCKVAACEATGRQLLTKPQH---QFVRPDVNSS--------CGEGYKLSGSVY 506

Query: 552 LDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNG------ 605
            +C  +  W     +C+ I CP       G+   S    +F  G+T  ++C+ G      
Sbjct: 507 QECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLE-DFPYGTTVTYTCNPGPERGVE 565

Query: 606 FKLEGPNNVECTTS----GRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGT 661
           F L G + + CT++    G WS   P CK    L    VQC  +       +  +  P  
Sbjct: 566 FSLIGESTIRCTSNDQERGTWSGPAPLCK----LSLLAVQCSHVHIANGYKISGKEAP-- 619

Query: 662 FGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLW 721
           + +N T  F C +GFTL G S + C+    W    P C      E     P  ++     
Sbjct: 620 YFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVC------EKGCQSPPGLHHGRHT 673

Query: 722 GN----FSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEAL 772
           G     F  G    + C  G LL G+    C  +G+WS + P C+     ++++L
Sbjct: 674 GGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEETCQHVRQSL 728



 Score =  199 bits (505), Expect = 1e-50
 Identities = 159/596 (26%), Positives = 235/596 (39%), Gaps = 59/596 (9%)

Query: 192 PECEYVRECGELELPQHVLMNC-SHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIW 250
           P CE      +   PQ +     S     +++N    F C  G+ + G  ++ C A G W
Sbjct: 340 PRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTW 399

Query: 251 TNKPPQC-LAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTAS 309
               P C    Q PP  +   G     H  + F   +S  +SC  G+ LVG E +QCT+ 
Sbjct: 400 EPSAPVCEKECQAPPNIL--NGQKEDRHMVR-FDPGTSIKYSCNPGYVLVGEESIQCTSE 456

Query: 310 GVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCI 369
           GVWT P P CK   C+     + G      P   F         C  GY++ G     C 
Sbjct: 457 GVWTPPVPQCKVAACE-----ATGRQLLTKPQHQFV-RPDVNSSCGEGYKLSGSVYQECQ 510

Query: 370 DSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEG------FMLR 423
            +  W   +  C+ I+C P    ++       SL  F Y T  ++ C  G      F L 
Sbjct: 511 GTIPWFMEIRLCKEITCPP-PPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLI 569

Query: 424 GADIVRC----DNLGQWTAPAPVCQ----ALQCQDLPVPNEARVNCSHPFGAFRYQSVCS 475
           G   +RC       G W+ PAP+C+    A+QC  + + N  ++  S     + Y    +
Sbjct: 570 GESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKI--SGKEAPYFYNDTVT 627

Query: 476 FTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKST 535
           F C  G  L G+S ++C A   W+   P C+   C       +G  T    +   S   T
Sbjct: 628 FKCYSGFTLKGSSQIRCKADNTWDPEIPVCEK-GCQSPPGLHHGRHTGGNTVFFVS-GMT 685

Query: 536 CQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVG 595
             + CD GY L G + + C  SG W+ S P CE     E     + SL          + 
Sbjct: 686 VDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCE-----ETCQHVRQSLQELPAGSRVELV 740

Query: 596 STCHFSCDNGFKLEGPNNVEC--TTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTM 653
           +T   SC +G++L G     C    +G W    P CK I   P      P +   G+ T 
Sbjct: 741 NT---SCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHP------PPVIVNGKHTG 791

Query: 654 YCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPS----GQWTAVTPAC----RAVKCS 705
               +   F +     + C+ GF L+G+  L CR      G W+  +P C       +C 
Sbjct: 792 MMAEN---FLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCP 848

Query: 706 ELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
              V     +N ++    +S+  I    C  G ++NGS    C  +  W   VPTC
Sbjct: 849 NPEVKHGYKLNKTH--SAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTC 902



 Score =  189 bits (480), Expect = 9e-48
 Identities = 142/570 (24%), Positives = 233/570 (40%), Gaps = 65/570 (11%)

Query: 230  CTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCS 289
            C +GY+++G    EC  +  W  +   C    CPP  +   G  T   S + F + ++ +
Sbjct: 495  CGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTG-SSLEDFPYGTTVT 553

Query: 290  FSCEEG------FALVGPEVVQCTAS----GVWTAPAPVCK----AVQCQHLEAPSEGTM 335
            ++C  G      F+L+G   ++CT++    G W+ PAP+CK    AVQC H+   +   +
Sbjct: 554  YTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKI 613

Query: 336  DCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHG 395
                    + Y  +  F+C  G+ ++G   +RC     W   +P CE   C+      HG
Sbjct: 614  SGKE--APYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEK-GCQSPPGLHHG 670

Query: 396  SMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDL---- 451
                  ++  F       + C  G++L G   + C   G W+  AP C+   CQ +    
Sbjct: 671  RHTGGNTV-FFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEET-CQHVRQSL 728

Query: 452  -PVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQC--LATGNWNSVPPECQAI 508
              +P  +RV             + + +C +G  L G +   C     G W    P C+ I
Sbjct: 729  QELPAGSRVE------------LVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVI 776

Query: 509  PCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRS----GRWTDSP 564
             C P     NG  T +    +  Y +   + CD+G+ L G ++L C       G W+   
Sbjct: 777  HCHPPPVIVNGKHTGMMA-ENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPS 835

Query: 565  PMC----EAIKCPELFAPE-QGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTS 619
            P C       +CP    PE +     + T   ++     +  C+ GF + G   + C T 
Sbjct: 836  PQCLRSPPVTRCPN---PEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTD 892

Query: 620  GRWSATPPTCKGIASLPTPGVQCPALTTPG---QGTMYCRHHPGTFGFNTTCYFGCNAGF 676
              W    PTC   A +  P    P   TP     G    R  PG      +  + C+ G+
Sbjct: 893  NTWVPGVPTCIKKAFIGCP----PPPKTPNGNHTGGNIARFSPGM-----SILYSCDQGY 943

Query: 677  TLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLE 736
             L+G++ L C   G W+   P C+ V CS       I          + YG++ +  C +
Sbjct: 944  LLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPR-KMYQYGAVVTLECED 1002

Query: 737  GQLLNGSAQTACQENGHWSTTVPTCQAGPL 766
            G +L GS Q+ CQ +  W+  +  C++  L
Sbjct: 1003 GYMLEGSPQSQCQSDHQWNPPLAVCRSRSL 1032



 Score =  161 bits (408), Expect = 2e-39
 Identities = 113/433 (26%), Positives = 179/433 (41%), Gaps = 34/433 (7%)

Query: 220  FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQC-LAAQCPPLKIPER--GNMTCL 276
            + +N   +F C  G+ + G S++ C A   W  + P C    Q PP     R  G  T  
Sbjct: 620  YFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKGCQSPPGLHHGRHTGGNTVF 679

Query: 277  HSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMD 336
                 F    +  ++C+ G+ LVG + + C  SG W+  AP C+   CQH+         
Sbjct: 680  -----FVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEET-CQHVR-------Q 726

Query: 337  CVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDS--GHWSAPLPTCEAISCEPLESPVH 394
             +  L A +        CQ GY++ G     C D+  G W   +P C+ I C P    V+
Sbjct: 727  SLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVN 786

Query: 395  GSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDN----LGQWTAPAPVC----QAL 446
            G          F Y    S+ C +GF L G   ++C +     G W+ P+P C       
Sbjct: 787  GK-HTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVT 845

Query: 447  QCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPEC- 505
            +C +  V +  ++N +H   A+ +  +    CN G ++ G+ V++C     W    P C 
Sbjct: 846  RCPNPEVKHGYKLNKTH--SAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCI 903

Query: 506  --QAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDS 563
                I C P     NG  T    +   S   +  + CD+GY L G   L CT  G W+  
Sbjct: 904  KKAFIGCPPPPKTPNGNHTGGN-IARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQP 962

Query: 564  PPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWS 623
             P C+ + C    A   G     + R  +  G+     C++G+ LEG    +C +  +W+
Sbjct: 963  APHCKEVNCSSP-ADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWN 1021

Query: 624  ATPPTCKGIASLP 636
                 C+  +  P
Sbjct: 1022 PPLAVCRSRSLAP 1034



 Score =  159 bits (403), Expect = 8e-39
 Identities = 131/505 (25%), Positives = 202/505 (40%), Gaps = 62/505 (12%)

Query: 290 FSCEEGFALVGPEVVQCTAS----GVWTAPAPVC----KAVQCQHLEAPSEGTMDCVHPL 341
           +SC   F L+G + + C       G W  PAP C    K   C     P       +   
Sbjct: 49  YSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYK---IRGS 105

Query: 342 TAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWS-APLPTCEAISCEPLESP----VHGS 396
           T + +G S  F C+  + + G   + C  +  W    LPTC  +S  PLE P    +H  
Sbjct: 106 TPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTC--VSVFPLECPALPMIHNG 163

Query: 397 MDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNE 456
              S ++ +     + ++ C  G++L G  I+ C + G+W+A  P C+  +C+ L     
Sbjct: 164 HHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPN 223

Query: 457 ARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGN---WNSVPPECQAIPCTPL 513
            +V    P    R     +F C+EG  L G    +C+  G    W  + P C+ I C P 
Sbjct: 224 GKVK-EPPI--LRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKM-PVCEEIFC-PS 278

Query: 514 LSPQNGTMTCVQPLGSSSYKSTCQFICD----EG--YSLSGPERLDCT----RSGRWTDS 563
             P          L + SY S   + CD    EG  + L G   L CT    ++G W+  
Sbjct: 279 PPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGP 338

Query: 564 PPMCE----AIKCPELFAPE--QGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECT 617
            P CE    A++CP    P+  +G +  S  +  +    T  F+C  GF L+G   + C 
Sbjct: 339 APRCELSTSAVQCPH---PQILRGRM-VSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCN 394

Query: 618 TSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFT 677
             G W  + P C+     P P +    L    +     R  PG     T+  + CN G+ 
Sbjct: 395 AQGTWEPSAPVCEKECQAP-PNI----LNGQKEDRHMVRFDPG-----TSIKYSCNPGYV 444

Query: 678 LIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEG 737
           L+G+ ++ C   G WT   P C+   C      + +     + +      S C     EG
Sbjct: 445 LVGEESIQCTSEGVWTPPVPQCKVAACEA--TGRQLLTKPQHQFVRPDVNSSCG----EG 498

Query: 738 QLLNGSAQTACQENGHWSTTVPTCQ 762
             L+GS    CQ    W   +  C+
Sbjct: 499 YKLSGSVYQECQGTIPWFMEIRLCK 523



 Score =  157 bits (397), Expect = 4e-38
 Identities = 126/453 (27%), Positives = 177/453 (39%), Gaps = 56/453 (12%)

Query: 342 TAFAYGSSCKFECQPGYRVRGLDMLRCID----SGHWSAPLPTCEAI----SC-EPLESP 392
           T  A G+  ++ C   +R+ G   L CI      G W  P P CE      SC EP+   
Sbjct: 39  TPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPG 98

Query: 393 VHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQW-TAPAPVCQA---LQC 448
            +     +P    +++  + +F C   F + G   V C     W     P C +   L+C
Sbjct: 99  GYKIRGSTP----YRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLEC 154

Query: 449 QDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAI 508
             LP+ +    + S   G+       +++C  G LLVG  ++ CL++G W++VPP C+  
Sbjct: 155 PALPMIHNGH-HTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEA 213

Query: 509 PCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR---WTDSPP 565
            C  L    NG    V+         T  F CDEGY L GP    C  +G+   WT   P
Sbjct: 214 RCKSLGRFPNGK---VKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMP 269

Query: 566 MCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDN------GFKLEGPNNVECTT- 618
           +CE I CP    P        ++    + GS   ++CD        F L G + + CT  
Sbjct: 270 VCEEIFCPSP-PPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVD 328

Query: 619 ---SGRWSATPPTCKGIASLPTPGVQCP------ALTTPGQGTMYCRHHPGTFGFNTTCY 669
              +G WS   P C+    L T  VQCP           GQ   Y         +N T  
Sbjct: 329 SQKTGTWSGPAPRCE----LSTSAVQCPHPQILRGRMVSGQKDRYT--------YNDTVI 376

Query: 670 FGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSI 729
           F C  GFTL G   + C   G W    P C   K  +   N             F  G+ 
Sbjct: 377 FACMFGFTLKGSKQIRCNAQGTWEPSAPVCE--KECQAPPNILNGQKEDRHMVRFDPGTS 434

Query: 730 CSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762
             + C  G +L G     C   G W+  VP C+
Sbjct: 435 IKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCK 467



 Score =  132 bits (331), Expect = 2e-30
 Identities = 92/355 (25%), Positives = 154/355 (43%), Gaps = 33/355 (9%)

Query: 178  IGNYTCSCYPGFY----GPECEYVRECGELELPQHVLMNCSH-PLGNFSFNSQCSFHCTD 232
            +GN +  C P        P CE        E  QHV  +    P G  S     +  C D
Sbjct: 697  VGNKSIHCMPSGNWSPSAPRCE--------ETCQHVRQSLQELPAG--SRVELVNTSCQD 746

Query: 233  GYQVNGPSKLEC--LASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSF 290
            GYQ+ G +   C    +GIW  K P C    C P  +   G  T +  A+ F + +  S+
Sbjct: 747  GYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGM-MAENFLYGNEVSY 805

Query: 291  SCEEGFALVGPEVVQCTAS----GVWTAPAPVC----KAVQCQHLEAPSEGTMDCVHPLT 342
             C++GF L+G + +QC +     G W+ P+P C       +C + E      ++  H  +
Sbjct: 806  ECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTH--S 863

Query: 343  AFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC---EAISCEPLESPVHGSMDC 399
            A+++      +C PG+ + G  ++RC     W   +PTC     I C P     +G+   
Sbjct: 864  AYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGN-HT 922

Query: 400  SPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARV 459
              ++  F    +  + C +G++L G  ++ C + G W+ PAP C+ + C   P   +   
Sbjct: 923  GGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSS-PADMDGIQ 981

Query: 460  NCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLL 514
                P   ++Y +V +  C +G +L G+   QC +   WN     C++    P+L
Sbjct: 982  KGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVL 1036


>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
           isoform 2 [Homo sapiens]
          Length = 1033

 Score =  216 bits (551), Expect = 5e-56
 Identities = 174/617 (28%), Positives = 257/617 (41%), Gaps = 84/617 (13%)

Query: 192 PECEYVRE---CGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASG 248
           P+CEY  +   C E  +P    +  S P   +      +F C   + +NG   + C A+ 
Sbjct: 80  PKCEYFNKYSSCPEPIVPGGYKIRGSTP---YRHGDSVTFACKTNFSMNGNKSVWCQANN 136

Query: 249 IW-TNKPPQCLAA---QCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVV 304
           +W   + P C++    +CP L +   G+ T   +  +     S ++SCE G+ LVG +++
Sbjct: 137 MWGPTRLPTCVSVFPLECPALPMIHNGHHTS-ENVGSIAPGLSVTYSCESGYLLVGEKII 195

Query: 305 QCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLD 364
            C +SG W+A  P C+  +C+ L     G    V        G +  F C  GYR++G  
Sbjct: 196 NCLSSGKWSAVPPTCEEARCKSLGRFPNGK---VKEPPILRVGVTANFFCDEGYRLQGPP 252

Query: 365 MLRCIDSGHWSA--PLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRC----AE 418
             RC+ +G   A   +P CE I C P   P+        SL    Y +  ++ C     E
Sbjct: 253 SSRCVIAGQGVAWTKMPVCEEIFC-PSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEE 311

Query: 419 G--FMLRGADIVRC----DNLGQWTAPAPVCQ----ALQCQDLPVPNEARVN-CSHPFGA 467
           G  F+L G   +RC       G W+ PAP C+    A+QC   P P   R    S     
Sbjct: 312 GVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQC---PHPQILRGRMVSGQKDR 368

Query: 468 FRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPP----ECQAIPCTPLLSPQNGTMTC 523
           + Y     F C  G  L G+  ++C A G W    P    ECQA P   +L+ Q      
Sbjct: 369 YTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPP--NILNGQKEDRHM 426

Query: 524 VQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSL 583
           V+    +S K    + C+ GY L G E + CT  G WT   P C+   C        G  
Sbjct: 427 VRFDPGTSIK----YSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAAC-----EATGRQ 477

Query: 584 DCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCP 643
             +  + +F V    + SC  G+KL G    EC  +  W      CK I   P P     
Sbjct: 478 LLTKPQHQF-VRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPP----- 531

Query: 644 ALTTPGQGTMYCRHHPGT----FGFNTTCYFGCNAG------FTLIGDSTLSC----RPS 689
                    +Y   H G+    F + TT  + CN G      F+LIG+ST+ C    +  
Sbjct: 532 --------VIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQER 583

Query: 690 GQWTAVTPACR----AVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQ 745
           G W+   P C+    AV+CS +H+        S     + Y    +F C  G  L GS+Q
Sbjct: 584 GTWSGPAPLCKLSLLAVQCSHVHIAN--GYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQ 641

Query: 746 TACQENGHWSTTVPTCQ 762
             C+ +  W   +P C+
Sbjct: 642 IRCKADNTWDPEIPVCE 658



 Score =  204 bits (519), Expect = 3e-52
 Identities = 159/603 (26%), Positives = 231/603 (38%), Gaps = 66/603 (10%)

Query: 192 PECEYVRECGELELPQHVLMNC-SHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIW 250
           P CE      +   PQ +     S     +++N    F C  G+ + G  ++ C A G W
Sbjct: 340 PRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTW 399

Query: 251 TNKPPQC-LAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTAS 309
               P C    Q PP  +   G     H  + F   +S  +SC  G+ LVG E +QCT+ 
Sbjct: 400 EPSAPVCEKECQAPPNIL--NGQKEDRHMVR-FDPGTSIKYSCNPGYVLVGEESIQCTSE 456

Query: 310 GVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCI 369
           GVWT P P CK   C+     + G      P   F         C  GY++ G     C 
Sbjct: 457 GVWTPPVPQCKVAACE-----ATGRQLLTKPQHQFV-RPDVNSSCGEGYKLSGSVYQECQ 510

Query: 370 DSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEG------FMLR 423
            +  W   +  C+ I+C P    ++       SL  F Y T  ++ C  G      F L 
Sbjct: 511 GTIPWFMEIRLCKEITCPP-PPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLI 569

Query: 424 GADIVRC----DNLGQWTAPAPVCQ----ALQCQDLPVPNEARVNCSHPFGAFRYQSVCS 475
           G   +RC       G W+ PAP+C+    A+QC  + + N  ++  S     + Y    +
Sbjct: 570 GESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKI--SGKEAPYFYNDTVT 627

Query: 476 FTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKST 535
           F C  G  L G+S ++C A   W+   P C+   C             +Q L + S    
Sbjct: 628 FKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETC-------QHVRQSLQELPAGSRVEL 680

Query: 536 CQFICDEGYSLSGPERLDC--TRSGRWTDSPPMCEAIKC---PELFAPEQGSLDCSDTRG 590
               C +GY L+G     C    +G W    P+C+ I C   P +   +   +   +   
Sbjct: 681 VNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAEN--- 737

Query: 591 EFNVGSTCHFSCDNGFKLEGPNNVECTTS----GRWSATPPTCKGIASLPTPGV-QCPAL 645
            F  G+   + CD GF L G   ++C +     G WS   P C     L +P V +CP  
Sbjct: 738 -FLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQC-----LRSPPVTRCPNP 791

Query: 646 TTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPAC---RAV 702
                  +   H    +  N   Y  CN GF + G   + C     W    P C     +
Sbjct: 792 EVKHGYKLNKTH--SAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFI 849

Query: 703 KCSELHVNKPIAMNCSNLWGN---FSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVP 759
            C       P   N ++  GN   FS G    + C +G LL G A   C   G WS   P
Sbjct: 850 GCPP----PPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAP 905

Query: 760 TCQ 762
            C+
Sbjct: 906 HCK 908



 Score =  186 bits (472), Expect = 8e-47
 Identities = 159/583 (27%), Positives = 249/583 (42%), Gaps = 71/583 (12%)

Query: 228 FHCTDGYQVNGPSKLECLAS----GIWTNKPPQC----LAAQCPPLKIPERGNMTCLHSA 279
           + C+  +++ G   L C+      G W    P+C      + CP   +P       +  +
Sbjct: 49  YSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYK---IRGS 105

Query: 280 KAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVH 339
             ++H  S +F+C+  F++ G + V C A+ +W  P  +   V    LE P+   +   H
Sbjct: 106 TPYRHGDSVTFACKTNFSMNGNKSVWCQANNMW-GPTRLPTCVSVFPLECPALPMIHNGH 164

Query: 340 PLT----AFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHG 395
             +    + A G S  + C+ GY + G  ++ C+ SG WSA  PTCE   C+ L    +G
Sbjct: 165 HTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNG 224

Query: 396 SMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ---WTAPAPVCQALQCQDLP 452
            +   P LR        +F C EG+ L+G    RC   GQ   WT   PVC+ + C   P
Sbjct: 225 KVKEPPILRV---GVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTK-MPVCEEIFCPSPP 280

Query: 453 VPNEARVNCSHPFGAFRYQSVCSFTCN----EGL--LLVGASVLQCLA----TGNWNSVP 502
                R +  +      Y S+ ++TC+    EG+  +L+G S L+C      TG W+   
Sbjct: 281 PILNGR-HIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPA 339

Query: 503 PECQ----AIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSG 558
           P C+    A+ C P      G M   Q     +Y  T  F C  G++L G +++ C   G
Sbjct: 340 PRCELSTSAVQC-PHPQILRGRMVSGQK-DRYTYNDTVIFACMFGFTLKGSKQIRCNAQG 397

Query: 559 RWTDSPPMCEAIKCPELFAPEQGSLDCSDTRG--EFNVGSTCHFSCDNGFKLEGPNNVEC 616
            W  S P+CE     E  AP        + R    F+ G++  +SC+ G+ L G  +++C
Sbjct: 398 TWEPSAPVCEK----ECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQC 453

Query: 617 TTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGF 676
           T+ G W+   P CK +A+    G Q   LT P       +H       N++C      G+
Sbjct: 454 TSEGVWTPPVPQCK-VAACEATGRQL--LTKP-------QHQFVRPDVNSSC----GEGY 499

Query: 677 TLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLE 736
            L G     C+ +  W      C+ + C    V    A   S+L  +F YG+  ++ C  
Sbjct: 500 KLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSL-EDFPYGTTVTYTCNP 558

Query: 737 GQ------LLNGSAQTAC----QENGHWSTTVPTCQAGPLTIQ 769
           G        L G +   C    QE G WS   P C+   L +Q
Sbjct: 559 GPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQ 601



 Score =  162 bits (410), Expect = 1e-39
 Identities = 118/471 (25%), Positives = 193/471 (40%), Gaps = 45/471 (9%)

Query: 197 VRECGELELPQH-VLMNCSHP---LGNFSFNSQCSFHCTDG------YQVNGPSKLECLA 246
           +R C E+  P   V+ N +H    L +F + +  ++ C  G      + + G S + C +
Sbjct: 519 IRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTS 578

Query: 247 S----GIWTNKPPQC----LAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFAL 298
           +    G W+   P C    LA QC  + I     ++   +   + +  + +F C  GF L
Sbjct: 579 NDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAP--YFYNDTVTFKCYSGFTL 636

Query: 299 VGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGY 358
            G   ++C A   W    PVC+   CQH+          +  L A +        CQ GY
Sbjct: 637 KGSSQIRCKADNTWDPEIPVCEKETCQHVR-------QSLQELPAGSRVELVNTSCQDGY 689

Query: 359 RVRGLDMLRCIDS--GHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRC 416
           ++ G     C D+  G W   +P C+ I C P    V+G          F Y    S+ C
Sbjct: 690 QLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGK-HTGMMAENFLYGNEVSYEC 748

Query: 417 AEGFMLRGADIVRCDN----LGQWTAPAPVC----QALQCQDLPVPNEARVNCSHPFGAF 468
            +GF L G   ++C +     G W+ P+P C       +C +  V +  ++N +H   A+
Sbjct: 749 DQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTH--SAY 806

Query: 469 RYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPEC---QAIPCTPLLSPQNGTMTCVQ 525
            +  +    CN G ++ G+ V++C     W    P C     I C P     NG  T   
Sbjct: 807 SHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGN 866

Query: 526 PLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDC 585
            +   S   +  + CD+GY L G   L CT  G W+   P C+ + C    A   G    
Sbjct: 867 -IARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSP-ADMDGIQKG 924

Query: 586 SDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLP 636
            + R  +  G+     C++G+ LEG    +C +  +W+     C+  +  P
Sbjct: 925 LEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAP 975



 Score =  157 bits (397), Expect = 4e-38
 Identities = 126/453 (27%), Positives = 177/453 (39%), Gaps = 56/453 (12%)

Query: 342 TAFAYGSSCKFECQPGYRVRGLDMLRCID----SGHWSAPLPTCEAI----SC-EPLESP 392
           T  A G+  ++ C   +R+ G   L CI      G W  P P CE      SC EP+   
Sbjct: 39  TPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPG 98

Query: 393 VHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQW-TAPAPVCQA---LQC 448
            +     +P    +++  + +F C   F + G   V C     W     P C +   L+C
Sbjct: 99  GYKIRGSTP----YRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLEC 154

Query: 449 QDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAI 508
             LP+ +    + S   G+       +++C  G LLVG  ++ CL++G W++VPP C+  
Sbjct: 155 PALPMIHNGH-HTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEA 213

Query: 509 PCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR---WTDSPP 565
            C  L    NG    V+         T  F CDEGY L GP    C  +G+   WT   P
Sbjct: 214 RCKSLGRFPNGK---VKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWT-KMP 269

Query: 566 MCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDN------GFKLEGPNNVECTT- 618
           +CE I CP    P        ++    + GS   ++CD        F L G + + CT  
Sbjct: 270 VCEEIFCPSP-PPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVD 328

Query: 619 ---SGRWSATPPTCKGIASLPTPGVQCP------ALTTPGQGTMYCRHHPGTFGFNTTCY 669
              +G WS   P C+    L T  VQCP           GQ   Y         +N T  
Sbjct: 329 SQKTGTWSGPAPRCE----LSTSAVQCPHPQILRGRMVSGQKDRYT--------YNDTVI 376

Query: 670 FGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSI 729
           F C  GFTL G   + C   G W    P C   K  +   N             F  G+ 
Sbjct: 377 FACMFGFTLKGSKQIRCNAQGTWEPSAPVCE--KECQAPPNILNGQKEDRHMVRFDPGTS 434

Query: 730 CSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762
             + C  G +L G     C   G W+  VP C+
Sbjct: 435 IKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCK 467



 Score =  130 bits (327), Expect = 5e-30
 Identities = 91/358 (25%), Positives = 153/358 (42%), Gaps = 32/358 (8%)

Query: 182 TCSCYPGFYGPECEYVR----ECGELELPQHVLMNCSH--------PLGNFSFNSQCSFH 229
           T  CY GF       +R       + E+P      C H        P G  S     +  
Sbjct: 627 TFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAG--SRVELVNTS 684

Query: 230 CTDGYQVNGPSKLEC--LASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSS 287
           C DGYQ+ G +   C    +GIW  K P C    C P  +   G  T +  A+ F + + 
Sbjct: 685 CQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGM-MAENFLYGNE 743

Query: 288 CSFSCEEGFALVGPEVVQCTAS----GVWTAPAPVC----KAVQCQHLEAPSEGTMDCVH 339
            S+ C++GF L+G + +QC +     G W+ P+P C       +C + E      ++  H
Sbjct: 744 VSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTH 803

Query: 340 PLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC---EAISCEPLESPVHGS 396
             +A+++      +C PG+ + G  ++RC     W   +PTC     I C P     +G+
Sbjct: 804 --SAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGN 861

Query: 397 MDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNE 456
                ++  F    +  + C +G++L G  ++ C + G W+ PAP C+ + C   P   +
Sbjct: 862 -HTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSS-PADMD 919

Query: 457 ARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLL 514
                  P   ++Y +V +  C +G +L G+   QC +   WN     C++    P+L
Sbjct: 920 GIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVL 977


>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
          Length = 3487

 Score =  215 bits (548), Expect = 1e-55
 Identities = 157/580 (27%), Positives = 228/580 (39%), Gaps = 55/580 (9%)

Query: 192  PECEYVRECGELELPQHVLMNCSHPLGNFS-FNSQCSFHCTDGYQVNGPSKLECLASGIW 250
            P C  +  CGEL +P +      H +G  S + +   F C  GY + G    EC+A+G+W
Sbjct: 2651 PTCRII-SCGELPIPPN-----GHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLW 2704

Query: 251  TNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASG 310
            +    +CLA  C   +    G++    + + + ++ S  + C  GF L+G  V  C    
Sbjct: 2705 SGSEVRCLAGHCGTPEPIVNGHI----NGENYSYRGSVVYQCNAGFRLIGMSVRICQQDH 2760

Query: 311  VWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCID 370
             W+   P C  V C H  +P    M       ++  G+  ++ C     + G     C  
Sbjct: 2761 HWSGKTPFCVLVSCGHPGSPPHSQMSG----DSYTVGAVVRYSCIGKRTLVGNSTRMCGL 2816

Query: 371  SGHWSAPLPTCEAIS---CEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADI 427
             GHW+  LP C   S   C     P HG         +F   T   F C  G +LRG+  
Sbjct: 2817 DGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGD----SFDPGTVMRFSCEAGHVLRGSSE 2872

Query: 428  VRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGA 487
              C   G W+   P C  + C +   P+ ARV  S       + S   + C EG    G 
Sbjct: 2873 RTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSD---GLVFSSSIVYECREGYYATGL 2929

Query: 488  SVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSS-SYKSTCQFICDEGYSL 546
                C   G W    PEC  I C     P NG       LG+   Y  T  + C  GY +
Sbjct: 2930 LSRHCSVNGTWTGSDPECLVINCGDPGIPANGLR-----LGNDFRYNKTVTYQCVPGYMM 2984

Query: 547  SGPER--LDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDN 604
                   L CT+   W  + P+C+A+ C        G +  SD    F  GS+  ++C  
Sbjct: 2985 ESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSD----FMWGSSVTYACLE 3040

Query: 605  GFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGF 664
            G++L  P    C  +G W+   P C  +     PGV       P +G    R     F +
Sbjct: 3041 GYQLSLPAVFTCEGNGSWTGELPQCFPVFC-GDPGV-------PSRG----RREDRGFSY 3088

Query: 665  NTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPAC---RAVKCSELHVNKPIAMNCSNLW 721
             ++  F C+    L+G     C+  G W+   P+C       C++  V +    N S   
Sbjct: 3089 RSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQ-- 3146

Query: 722  GNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
              +  GS   F C +G LL GS    C  N  WS T P C
Sbjct: 3147 -GYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDC 3185



 Score =  210 bits (535), Expect = 4e-54
 Identities = 165/623 (26%), Positives = 242/623 (38%), Gaps = 54/623 (8%)

Query: 159  YTASCQDMSCSKQGECLETIGNYTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPLG 218
            YT   + M    +G  L+     T  C             +C  +  P    ++  H   
Sbjct: 2547 YTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRW 2606

Query: 219  NFSFNSQCSFH------CTDGYQVNGPSKLECLASGIWT--NKPPQCLAAQCPPLKIPER 270
               F +Q  F       C  GY   G   + C A+G W+  +  P C    C  L IP  
Sbjct: 2607 RLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPN 2666

Query: 271  GNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAP 330
            G+     S     + ++  FSC  G+ LVG  V +C A+G+W+     C A  C   E  
Sbjct: 2667 GHRIGTLSV----YGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPI 2722

Query: 331  SEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLE 390
              G ++  +    ++Y  S  ++C  G+R+ G+ +  C    HWS   P C  +SC    
Sbjct: 2723 VNGHINGEN----YSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPG 2778

Query: 391  SPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQ--- 447
            SP H  M    S  ++       + C     L G     C   G WT   P C       
Sbjct: 2779 SPPHSQM----SGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGV 2834

Query: 448  CQDLPVP-NEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQ 506
            C D  +P +  R+  S   G     +V  F+C  G +L G+S   C A G+W+   PEC 
Sbjct: 2835 CGDPGIPAHGIRLGDSFDPG-----TVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECG 2889

Query: 507  AIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPM 566
             I C    +P N  +     L    + S+  + C EGY  +G     C+ +G WT S P 
Sbjct: 2890 VISCGNPGTPSNARVVFSDGL---VFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPE 2946

Query: 567  CEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEG--PNNVECTTSGRWSA 624
            C  I C +   P  G    +D    F    T  + C  G+ +E    + + CT    W+ 
Sbjct: 2947 CLVINCGDPGIPANGLRLGND----FRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNG 3002

Query: 625  TPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTL 684
            T P CK +   P P +  P     G   M+           ++  + C  G+ L   +  
Sbjct: 3003 TKPVCKALMCKPPPLI--PNGKVVGSDFMW----------GSSVTYACLEGYQLSLPAVF 3050

Query: 685  SCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSA 744
            +C  +G WT   P C  V C +      +          FSY S  SF C    +L GS 
Sbjct: 3051 TCEGNGSWTGELPQCFPVFCGD----PGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSP 3106

Query: 745  QTACQENGHWSTTVPTCQAGPLT 767
            +  CQ +G WS T P+C    LT
Sbjct: 3107 RRFCQSDGTWSGTQPSCIDPTLT 3129



 Score =  201 bits (512), Expect = 2e-51
 Identities = 172/652 (26%), Positives = 249/652 (38%), Gaps = 77/652 (11%)

Query: 141  APGKWNDEHCLKKKHALCYTASCQDMSCSKQGECLETIGNYTC----SCYPGFYGPECEY 196
            A GKW+    L      C   SC ++     G  + T+  Y      SC  G Y      
Sbjct: 2640 ANGKWS----LGDSTPTCRIISCGELPIPPNGHRIGTLSVYGATAIFSCNSG-YTLVGSR 2694

Query: 197  VREC---------------GELELPQHVLMNCSHPLG-NFSFNSQCSFHCTDGYQVNGPS 240
            VREC               G    P+ ++    H  G N+S+     + C  G+++ G S
Sbjct: 2695 VRECMANGLWSGSEVRCLAGHCGTPEPIVNG--HINGENYSYRGSVVYQCNAGFRLIGMS 2752

Query: 241  KLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVG 300
               C     W+ K P C+   C     P    M    S  ++   +   +SC     LVG
Sbjct: 2753 VRICQQDHHWSGKTPFCVLVSCGHPGSPPHSQM----SGDSYTVGAVVRYSCIGKRTLVG 2808

Query: 301  PEVVQCTASGVWTAPAPVCKAVQ---CQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPG 357
                 C   G WT   P C       C     P+ G    +    +F  G+  +F C+ G
Sbjct: 2809 NSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHG----IRLGDSFDPGTVMRFSCEAG 2864

Query: 358  YRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCA 417
            + +RG     C  +G WS   P C  ISC    +P +  +  S  L    + ++  + C 
Sbjct: 2865 HVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGL---VFSSSIVYECR 2921

Query: 418  EGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVP-NEARVNCSHPFGAFRYQSVCSF 476
            EG+   G     C   G WT   P C  + C D  +P N  R+        FRY    ++
Sbjct: 2922 EGYYATGLLSRHCSVNGTWTGSDPECLVINCGDPGIPANGLRLG-----NDFRYNKTVTY 2976

Query: 477  TCNEGLLLVG--ASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSS-SYK 533
             C  G ++     SVL C     WN   P C+A+ C P     NG +     +GS   + 
Sbjct: 2977 QCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKV-----VGSDFMWG 3031

Query: 534  STCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFN 593
            S+  + C EGY LS P    C  +G WT   P C  + C +   P +G     + RG F+
Sbjct: 3032 SSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGR---REDRG-FS 3087

Query: 594  VGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTT---PGQ 650
              S+  FSC     L G     C + G WS T P+C             P LTT   PG 
Sbjct: 3088 YRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCID-----------PTLTTCADPGV 3136

Query: 651  GTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVN 710
                 +++   +   +T  F C  G+ L G +T +C P+  W+   P C    C +    
Sbjct: 3137 PQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETP 3196

Query: 711  KPIAMNCSNLWGNFSYGSICSFHCLEG-QLLNGSAQTACQENGHWSTTVPTC 761
                +   +L    S G    + C EG  L  GS    C+ +G W+   P C
Sbjct: 3197 THANVGALDLP---SMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPIC 3245



 Score =  181 bits (458), Expect = 3e-45
 Identities = 143/527 (27%), Positives = 207/527 (39%), Gaps = 59/527 (11%)

Query: 206  PQHVLMNCSHPLG---------NFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQ 256
            P  VL++C HP           +++  +   + C     + G S   C   G WT   P 
Sbjct: 2767 PFCVLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPH 2826

Query: 257  CLAAQ---CPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWT 313
            C       C    IP  G    +    +F   +   FSCE G  L G     C A+G W+
Sbjct: 2827 CSGTSVGVCGDPGIPAHG----IRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWS 2882

Query: 314  APAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGH 373
               P C  + C +   PS   +     L    + SS  +EC+ GY   GL    C  +G 
Sbjct: 2883 GSQPECGVISCGNPGTPSNARVVFSDGLV---FSSSIVYECREGYYATGLLSRHCSVNGT 2939

Query: 374  WSAPLPTCEAISCEPLESPVHGSMDCSPSLRA---FQYDTNCSFRCAEGFMLRG--ADIV 428
            W+   P C  I+C     P +G       LR    F+Y+   +++C  G+M+      ++
Sbjct: 2940 WTGSDPECLVINCGDPGIPANG-------LRLGNDFRYNKTVTYQCVPGYMMESHRVSVL 2992

Query: 429  RCDNLGQWTAPAPVCQALQCQDLP-VPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGA 487
             C     W    PVC+AL C+  P +PN   V        F + S  ++ C EG  L   
Sbjct: 2993 SCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSD-----FMWGSSVTYACLEGYQLSLP 3047

Query: 488  SVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLS 547
            +V  C   G+W    P+C  + C     P  G     +     SY+S+  F C     L 
Sbjct: 3048 AVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGR----REDRGFSYRSSVSFSCHPPLVLV 3103

Query: 548  GPERLDCTRSGRWTDSPPMC---EAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDN 604
            G  R  C   G W+ + P C       C +   P+ G  + S     + VGST  F C  
Sbjct: 3104 GSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQG---YQVGSTVLFRCQK 3160

Query: 605  GFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGF 664
            G+ L+G     C  +  WS TPP C     +P     C    TP    +     P + G+
Sbjct: 3161 GYLLQGSTTRTCLPNLTWSGTPPDC-----VPH---HCRQPETPTHANVGALDLP-SMGY 3211

Query: 665  NTTCYFGCNAGFTLIGDST-LSCRPSGQWTAVTPACRAVKCSELHVN 710
              T  + C  GF+L G S   +C+  G WT   P C  V+ S   +N
Sbjct: 3212 --TLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVRPSGRPIN 3256



 Score =  175 bits (443), Expect = 2e-43
 Identities = 127/496 (25%), Positives = 199/496 (40%), Gaps = 51/496 (10%)

Query: 283  QHQSSCSFSCEEGFALVGPEVVQCTASG----VWTAPAPVCKAVQCQHLEAPSEGTMDCV 338
            Q   S  F C  G+ LVG  +  CT       +W+   P+C+A+ C   EAP  G +   
Sbjct: 2486 QPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMVFG- 2544

Query: 339  HPLTAFAYGSSCKFECQPGYRVR-GLD-MLRCIDSGHWS---APLPTCEAISCEPLE--S 391
                 +  G+   + C  GY ++ G +    C+D+G WS    P P C  ++C  +   S
Sbjct: 2545 ---KEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVP-PQCVPVTCPDVSSIS 2600

Query: 392  PVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTA--PAPVCQALQCQ 449
              HG        + +Q+       C  G+   G  ++RC   G+W+     P C+ + C 
Sbjct: 2601 VEHGRWRLIFETQ-YQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCG 2659

Query: 450  DLPV-PNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAI 508
            +LP+ PN  R+     +GA        F+CN G  LVG+ V +C+A G W+     C A 
Sbjct: 2660 ELPIPPNGHRIGTLSVYGA-----TAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAG 2714

Query: 509  PCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCE 568
             C       NG +       + SY+ +  + C+ G+ L G     C +   W+   P C 
Sbjct: 2715 HCGTPEPIVNGHING----ENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCV 2770

Query: 569  AIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPT 628
             + C    +P    +    +   + VG+   +SC     L G +   C   G W+ + P 
Sbjct: 2771 LVSCGHPGSPPHSQM----SGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPH 2826

Query: 629  CKG--IASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSC 686
            C G  +     PG+       P  G         +F   T   F C AG  L G S  +C
Sbjct: 2827 CSGTSVGVCGDPGI-------PAHGIRL----GDSFDPGTVMRFSCEAGHVLRGSSERTC 2875

Query: 687  RPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGN-FSYGSICSFHCLEGQLLNGSAQ 745
            + +G W+   P C  + C     N     N   ++ +   + S   + C EG    G   
Sbjct: 2876 QANGSWSGSQPECGVISCG----NPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLS 2931

Query: 746  TACQENGHWSTTVPTC 761
              C  NG W+ + P C
Sbjct: 2932 RHCSVNGTWTGSDPEC 2947



 Score =  149 bits (376), Expect = 1e-35
 Identities = 122/465 (26%), Positives = 195/465 (41%), Gaps = 40/465 (8%)

Query: 347  GSSCKFECQPGYRVRGLDMLRCI--DSGH--WSAPLPTCEAISCEPLESPVHGSMDCSPS 402
            G S  F C  GYR+ G  M  C     G+  WS  +P C+A+SC   E+P +G +     
Sbjct: 2488 GGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMV----F 2543

Query: 403  LRAFQYDTNCSFRCAEGFMLR-GAD-IVRCDNLGQWT--APAPVCQALQCQDLPVPNEAR 458
             + +   T   + C+EG+ L+ GA+    C + G W+     P C  + C D+   +   
Sbjct: 2544 GKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEH 2603

Query: 459  VNCSHPFGA-FRYQSVCSFTCNEGLLLVGASVLQCLATGNWN--SVPPECQAIPCTPLLS 515
                  F   +++Q+     C+ G    G  V++C A G W+     P C+ I C  L  
Sbjct: 2604 GRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPI 2663

Query: 516  PQNGTMTCVQPLGS-SSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPE 574
            P NG       +G+ S Y +T  F C+ GY+L G    +C  +G W+ S   C A  C  
Sbjct: 2664 PPNG-----HRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGT 2718

Query: 575  LFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIAS 634
                  G ++  +    ++   +  + C+ GF+L G +   C     WS   P C  + S
Sbjct: 2719 PEPIVNGHINGEN----YSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCV-LVS 2773

Query: 635  LPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTA 694
               PG       +P    M       ++       + C    TL+G+ST  C   G WT 
Sbjct: 2774 CGHPG-------SPPHSQM----SGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTG 2822

Query: 695  VTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHW 754
              P C       +  +  I  +   L  +F  G++  F C  G +L GS++  CQ NG W
Sbjct: 2823 SLPHCSGTSVG-VCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSW 2881

Query: 755  STTVPTCQAGPLTIQEALTYFGGAVASTIGLIMGGTLLALLRKRF 799
            S + P C  G ++     T     V  + GL+   +++   R+ +
Sbjct: 2882 SGSQPEC--GVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGY 2924



 Score =  115 bits (288), Expect = 2e-25
 Identities = 72/244 (29%), Positives = 105/244 (43%), Gaps = 15/244 (6%)

Query: 219  NFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHS 278
            +F + S  ++ C +GYQ++ P+   C  +G WT + PQC    C    +P RG       
Sbjct: 3027 DFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGR----RE 3082

Query: 279  AKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCV 338
             + F ++SS SFSC     LVG     C + G W+   P C          P        
Sbjct: 3083 DRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQ 3142

Query: 339  HPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVH---G 395
            +    +  GS+  F CQ GY ++G     C+ +  WS   P C    C   E+P H   G
Sbjct: 3143 NNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVG 3202

Query: 396  SMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVR-CDNLGQWTAPAPVCQALQCQDLPVP 454
            ++D  PS+          + C EGF L+G    R C   G WT   P+C  ++    P+ 
Sbjct: 3203 ALDL-PSM-----GYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVRPSGRPI- 3255

Query: 455  NEAR 458
            N AR
Sbjct: 3256 NTAR 3259



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 140/622 (22%), Positives = 203/622 (32%), Gaps = 161/622 (25%)

Query: 261  QCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGF-ALVGPEVVQCT---ASGVWTAPA 316
            +CP   +P  G         + Q  SS SF C+EGF    G E + C     S VW +  
Sbjct: 690  ECPDPGVPVNGK----RFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNSAV 745

Query: 317  PVCKAVQCQHLEAPSEGTMDCVHP-LTAFAYGSSCKFECQPGYRVR----------GLDM 365
              C+A    HL +PS   +    P     A   +   E QPGY ++            D 
Sbjct: 746  LRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYDT 805

Query: 366  LRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGA 425
            L   D   +SA           PL    HG+      +  F   T+        ++L   
Sbjct: 806  LEVRDGRTYSA-----------PLIGVYHGT-----QVPQFLISTSNYL-----YLLFST 844

Query: 426  DIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLV 485
            D    D   Q        Q+  C D  +P    VN       F   ++ +F+C+ G  L 
Sbjct: 845  DKSHSDIGFQLRYETITLQSDHCLDPGIP----VNGQRHGNDFYVGALVTFSCDSGYTLS 900

Query: 486  GASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKS--TCQFICDEG 543
                L+C     W+   P C+A+ C   +   +GT+  + P     Y +   C +I +  
Sbjct: 901  DGEPLECEPNFQWSRALPSCEAL-CGGFIQGSSGTI--LSPGFPDFYPNNLNCTWIIETS 957

Query: 544  YSL------------SGPERLDCTRSGRWTDSPPMCEAIKCP------------------ 573
            +              SG + L  T +G +T         + P                  
Sbjct: 958  HGKGVFFTFHTFHLESGHDYLLITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFI 1017

Query: 574  -----------------ELFAPEQGSLDCSDTRG--EFNVGSTCHFSCDNGFKLEGPNNV 614
                             +L   E+  +     R   +F VG T  FSC  G++LEG   +
Sbjct: 1018 SDFSMSYEGFNITFSEYDLEPCEEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARI 1077

Query: 615  ECTTSGR--WSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTC---- 668
             C    R  WS+  P C           +C    T  QGT+   + P  +  N  C    
Sbjct: 1078 TCLGGRRRLWSSPLPRCV---------AECGNSVTGTQGTLLSPNFPVNYNNNHECIYSI 1128

Query: 669  -------------------------YFGCNAGFTLIG--------DSTLSCRPSGQW-TA 694
                                     Y G N    L+G          TL+   S  W   
Sbjct: 1129 QTQPGKGIQLKARAFELSEGDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDF 1188

Query: 695  VTPACRAVKCSELHVNKPIAMNCSNLW-----------GNFSYGSICSFHCLEGQLLNGS 743
            +T A    K  ELH +    + C +             G+F+ GS  SF C  G  L GS
Sbjct: 1189 ITDAENTSKGFELHFSSFELIKCEDPGTPKFGYKVHDEGHFA-GSSVSFSCDPGYSLRGS 1247

Query: 744  AQTAC--QENGHWSTTVPTCQA 763
             +  C   E   W   +PTC A
Sbjct: 1248 EELLCLSGERRTWDRPLPTCVA 1269



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 151/664 (22%), Positives = 228/664 (34%), Gaps = 157/664 (23%)

Query: 186  YPGFYGPECEYVRE-CGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLEC 244
            Y GF     EY  E C E E+P + +         F      +F C  GY++ G +++ C
Sbjct: 1024 YEGFNITFSEYDLEPCEEPEVPAYSIRKGLQ----FGVGDTLTFSCFPGYRLEGTARITC 1079

Query: 245  LASG--IWTNKPPQCLAAQC-------------PPLKIPERGNMTCLHS----------- 278
            L     +W++  P+C+A +C             P   +    N  C++S           
Sbjct: 1080 LGGRRRLWSSPLPRCVA-ECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQL 1138

Query: 279  -AKAFQHQSSCSFSCEEG----FALVGP--------EVVQCTASGVW----TAPAPVCKA 321
             A+AF+          +G      L+G           +  T+S +W    T      K 
Sbjct: 1139 KARAFELSEGDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKG 1198

Query: 322  ----------VQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDS 371
                      ++C+    P  G    VH    FA GSS  F C PGY +RG + L C+  
Sbjct: 1199 FELHFSSFELIKCEDPGTPKFGYK--VHDEGHFA-GSSVSFSCDPGYSLRGSEELLCLSG 1255

Query: 372  GH--WSAPLPTCEAISCEPLESPVHGSMDCSPSLRA-FQYDTNCSFR------CAEG--F 420
                W  PLPTC A     +   V G +  SP   A ++++ NC +       C  G  F
Sbjct: 1256 ERRTWDRPLPTCVAECGGTVRGEVSGQV-LSPGYPAPYEHNLNCIWTIEAEAGCTIGLHF 1314

Query: 421  MLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNE 480
            ++   + V  D L  W    PV   +  ++L  P   + +    F +   Q    F  ++
Sbjct: 1315 LVFDTEEVH-DVLRIW--DGPVESGVLLKELSGPALPK-DLHSTFNSVVLQFSTDFFTSK 1370

Query: 481  GLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFIC 540
                +  SV                 A  C     PQNG+ +      S     +  F C
Sbjct: 1371 QGFAIQFSV---------------STATSCNDPGIPQNGSRSG----DSWEAGDSTVFQC 1411

Query: 541  DEGYSLSGPERLDCTRSGR---WTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGST 597
            D GY+L G   + C +      W  SPP C A    +L  P  G +   +    +  G  
Sbjct: 1412 DPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGGDLTGP-SGVILSPNYPEPYPPGKE 1470

Query: 598  CHFSCD-----------NGFKLEGPNNVECTTSGRWSATP-------------------- 626
            C +              N F LE   +      GR S +P                    
Sbjct: 1471 CDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPGRIESSSNS 1530

Query: 627  --PTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGT------------FGFNTTCYFGC 672
                 +  AS+   G        P +        PG+             G + T Y  C
Sbjct: 1531 LFLAFRSDASVSNAGFVIDYTENPRESCF----DPGSIKNGTRVGSDLKLGSSVTYY--C 1584

Query: 673  NAGFTLIGDSTLSC--RPSGQ--WTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGS 728
            + G+ + G STLSC   P G+  W    P C A  C   +V     +   N   N++ G 
Sbjct: 1585 HGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTA-PCGGQYVGSDGVVLSPNYPQNYTSGQ 1643

Query: 729  ICSF 732
            IC +
Sbjct: 1644 ICLY 1647



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 74/297 (24%), Positives = 112/297 (37%), Gaps = 45/297 (15%)

Query: 260  AQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGV--WTAPAP 317
            + CP   +P  G  T     + +      SF CE G+AL G   + C    V  W  P P
Sbjct: 1907 SSCPEPAVPSNGVKT----GERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPP 1962

Query: 318  VCKAVQCQHLEAPSEG-------------TMDC----VHPLTAFAYGSSCKFECQPGY-- 358
            +C A QC       EG              MDC      P+   A+     F  +P +  
Sbjct: 1963 LCIA-QCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDY 2021

Query: 359  -RVRGLDMLRCIDSGHWS-APLPTCEAISCEPLESPVHGSMDCSPSLRAFQYD-TNCSFR 415
              +R          G +S + LP+  ++     E+ V+   D S +   F+ +  + ++ 
Sbjct: 2022 IEIRNGPYETSRMMGRFSGSELPS--SLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYS 2079

Query: 416  CAEGFMLRGADIVRCDNLGQWTAPA---------PVCQALQCQDLPVPNEARVNCSHPFG 466
                  LRG D+   +     T P          P C+A + Q+ P P           G
Sbjct: 2080 HQISSFLRGFDLSELERTNS-TPPVAASYVWDLDPGCEAYELQECPDPEPFANGIVRGAG 2138

Query: 467  AFRYQSVCSFTCNEGLLLVGASVLQCL--ATGNWNSVPPECQAIPCTPLLSPQNGTM 521
                QSV +F C  G  L G  VL C      NW+   P+C+ +PC   ++  NGT+
Sbjct: 2139 YNVGQSV-TFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCE-VPCGGNITSSNGTV 2193



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 98/441 (22%), Positives = 139/441 (31%), Gaps = 102/441 (23%)

Query: 276 LHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTA----SGVWTAPAPVCKA---------- 321
           +     F       +SC  GF L G  V+ C A    S  W  P P C+A          
Sbjct: 149 IQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADDACGGTLRG 208

Query: 322 ----VQCQHLEAPSEGTMDCVHPLTAFAYGSSC----KFECQPGYRVRGLDMLRCIDSGH 373
               +   H  +      DC   + A    +       F+ + GY    L++     S  
Sbjct: 209 QSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGYDF--LEVTGTEGSSL 266

Query: 374 W--SAPLPTCEAISCEPLESPVHGSMDCSPSLRAF--QYDTNCSFRCAEGFMLRGADIVR 429
           W   A LP     S   L   +H + D +   R F  QY              RG  ++ 
Sbjct: 267 WFTGASLPAPVISSKNWLR--LHFTSDGNHRQRGFSAQYQVKKQIELKS----RGVKLMP 320

Query: 430 CDNLGQWTAPAPVCQALQ----CQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLV 485
             +  Q T+        Q    C D  +P   +   S     FR  S   FTCNEG  L 
Sbjct: 321 SKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSD----FRLGSSVQFTCNEGYDLQ 376

Query: 486 GASVLQCLATGN----WNSVPPECQAIPCTPLLSPQNGTMT-------------CVQPLG 528
           G+  + C+   +    W+   P C+A  C   L   +G +T             CV  + 
Sbjct: 377 GSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNNAHCVWIIT 436

Query: 529 SSSYKSTC-----QFICDEGY----------------------SLSGPERLDCTRSGRW- 560
           + +          +F  + GY                        S P+ +  T    W 
Sbjct: 437 ALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWL 496

Query: 561 ---TDSPPMCEAIKCPELFAPEQGSLDCSD---------TRGEFNVGSTCHFSCDNGFKL 608
              TD        K       EQGS  C D             F+ G T  F C   F+L
Sbjct: 497 LFQTDGSGSSLGFKA-SYEEIEQGS--CGDPGIPAYGRREGSRFHHGDTLKFECQPAFEL 553

Query: 609 EGPNNVECTTSGRWSATPPTC 629
            G   + C  + +WSA  P C
Sbjct: 554 VGQKAITCQKNNQWSAKKPGC 574



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 57/240 (23%), Positives = 73/240 (30%), Gaps = 66/240 (27%)

Query: 262 CPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQC----TASGVWTAPAP 317
           CP   IPERG          F+  SS  F+C EG+ L G + + C         W+   P
Sbjct: 343 CPDPGIPERGKRL----GSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRP 398

Query: 318 VCKAVQCQ-HLEAPS------------EGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLD 364
           VC+A  C  HL  PS            +    CV  +TA       K   +     RG D
Sbjct: 399 VCRARMCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYD 458

Query: 365 MLRCIDSGH-----------------------------------------WSAPLPTCEA 383
            L   D G                                          + A     E 
Sbjct: 459 TLTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQ 518

Query: 384 ISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC 443
            SC     P +G  + S     F +     F C   F L G   + C    QW+A  P C
Sbjct: 519 GSCGDPGIPAYGRREGS----RFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGC 574



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 140/657 (21%), Positives = 212/657 (32%), Gaps = 130/657 (19%)

Query: 219  NFSFNSQCSFHCTDGYQVNGPSKLECL----ASGIWTNKPPQCLAAQCPPLKIPERG--- 271
            +    S  +++C  GY+V G S L C+       +W N  P C  A C    +   G   
Sbjct: 1573 DLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVC-TAPCGGQYVGSDGVVL 1631

Query: 272  ----------NMTCLHSAK-----------AFQHQ-------------------SSCSFS 291
                         CL+              AF H                    SS S S
Sbjct: 1632 SPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSLSGS 1691

Query: 292  -CEEGFALVGPEVVQCTASGVWTAPA----------PVCKAVQCQHLEAPSEGTMDCVHP 340
               E   L     V    S    APA          P   A QC  +  P  G       
Sbjct: 1692 HTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSSVPEPRYGK----RL 1747

Query: 341  LTAFAYGSSCKFECQPGYRVRGLDMLRCIDS----GHWSAPLPTCEAISCEPLESPVHGS 396
             + F+ G+  +FEC  GY ++G   + C+        W+   PTC  + C    +   G+
Sbjct: 1748 GSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTC-VVPCGGNLTERRGT 1806

Query: 397  MDCSPSLRAFQYDTNCSFRCA----EGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLP 452
            +        +    NC ++       G  ++    V   N   W        +L+  D  
Sbjct: 1807 ILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQN---W-------DSLEVFD-- 1854

Query: 453  VPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTP 512
               +  V     F      ++ + T N+ L L   S +   A G ++          C  
Sbjct: 1855 -GADNTVTMLGSFSGTTVPALLNSTSNQ-LYLHFYSDISVSAAG-FHLEYKTVGLSSCPE 1911

Query: 513  LLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSG--RWTDSPPMCEA- 569
               P NG  T  + L          F C+ GY+L G   + C      RW   PP+C A 
Sbjct: 1912 PAVPSNGVKTGERYL----VNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCIAQ 1967

Query: 570  -----------IKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTT 618
                       I  P        ++DCS  +    VG   H    N F  E  ++     
Sbjct: 1968 CGGTVEEMEGVILSPGFPGNYPSNMDCS-WKIALPVGFGAHIQFLN-FSTEPNHDYIEIR 2025

Query: 619  SGRWSATPPTCKGIAS-LPTPGVQCPALTTPGQGTMYCRHHPG--------TFGFNTTCY 669
            +G +  +    +   S LP+  +     TT    + + ++ PG        T+    + +
Sbjct: 2026 NGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQISSF 2085

Query: 670  FGCNAGFTLIG----DSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFS 725
                 GF L      +ST     S  W  + P C A +  E    +P A       G ++
Sbjct: 2086 L---RGFDLSELERTNSTPPVAASYVWD-LDPGCEAYELQECPDPEPFANGIVRGAG-YN 2140

Query: 726  YGSICSFHCLEGQLLNGSAQTACQE--NGHWSTTVPTCQ---AGPLTIQEALTYFGG 777
             G   +F CL G  L G     CQ   N +W   +P C+    G +T      Y  G
Sbjct: 2141 VGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNITSSNGTVYSPG 2197



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 57/260 (21%), Positives = 99/260 (38%), Gaps = 40/260 (15%)

Query: 220 FSFNSQCSFHCTDGYQVNGPSKLECLA----SGIWTNKPPQCLAAQ-CPPLKIPERGNMT 274
           F+   +  + C  G+ + G + L C A    S  W    P C A   C      + G ++
Sbjct: 155 FNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADDACGGTLRGQSGIIS 214

Query: 275 CLHSAKAFQHQSSCS-----------------FSCEEGFALVGPEVVQCTASGVW----T 313
             H    + + + C+                 F  E+G+  +  EV     S +W    +
Sbjct: 215 SPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGYDFL--EVTGTEGSSLWFTGAS 272

Query: 314 APAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGH 373
            PAPV  +     L   S+G     H    F+     K + +   + RG+ ++   D+  
Sbjct: 273 LPAPVISSKNWLRLHFTSDGN----HRQRGFSAQYQVKKQIE--LKSRGVKLMPSKDNSQ 326

Query: 374 WSAPLPTCEAISCEPLESPVHGSMDCSPSLRA-FQYDTNCSFRCAEGFMLRGADIVRC-- 430
            ++ L T   +S      P  G  +    L + F+  ++  F C EG+ L+G+  + C  
Sbjct: 327 KTSVL-TQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMK 385

Query: 431 --DNLGQWTAPAPVCQALQC 448
             D    W+   PVC+A  C
Sbjct: 386 VSDMFAAWSDHRPVCRARMC 405



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 46/226 (20%), Positives = 71/226 (31%), Gaps = 63/226 (27%)

Query: 219 NFSFNSQCSFHCTDGYQVNGPSKLECLASG----IWTNKPPQCLAAQC------------ 262
           +F   S   F C +GY + G  ++ C+        W++  P C A  C            
Sbjct: 358 DFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIIT 417

Query: 263 -PPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEG------------------------FA 297
            P   I    N  C+    A         + EE                         + 
Sbjct: 418 SPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYI 477

Query: 298 LVG---PEVVQCTASGVWT--------------APAPVCKAVQCQHLEAPSEGTMDCVHP 340
           L G   P+++  T   +W               A     +   C     P+ G  +    
Sbjct: 478 LTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDPGIPAYGRREG--- 534

Query: 341 LTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISC 386
            + F +G + KFECQP + + G   + C  +  WSA  P C   SC
Sbjct: 535 -SRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGC-VFSC 578



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 41/136 (30%), Positives = 51/136 (37%), Gaps = 23/136 (16%)

Query: 282  FQHQSSCSFSCEEGFALVGPEVVQCT----ASGVWTAPAPVCKAVQCQHLEAPSEGTMDC 337
            + HQ S   S   GF L   E    T    AS VW    P C+A + Q    P       
Sbjct: 2078 YSHQIS---SFLRGFDLSELERTNSTPPVAASYVWDLD-PGCEAYELQECPDPEPFANGI 2133

Query: 338  VHPLTAFAYGSSCKFECQPGYRVRGLDMLRCI--DSGHWSAPLPTCE------------A 383
            V     +  G S  FEC PGY++ G  +L C    + +W  PLP CE             
Sbjct: 2134 VRG-AGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNITSSNGT 2192

Query: 384  ISCEPLESPVHGSMDC 399
            +      SP   S DC
Sbjct: 2193 VYSPGFPSPYSSSQDC 2208



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 43/162 (26%), Positives = 61/162 (37%), Gaps = 20/162 (12%)

Query: 543  GYSLSGPERLDCT----RSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTC 598
            G+ LS  ER + T     S  W D  P CEA +  E   PE  +       G +NVG + 
Sbjct: 2088 GFDLSELERTNSTPPVAASYVW-DLDPGCEAYELQECPDPEPFANGIVRGAG-YNVGQSV 2145

Query: 599  HFSCDNGFKLEGPNNVECT--TSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCR 656
             F C  G++L G   + C   T+  W    P C+         V C    T   GT+Y  
Sbjct: 2146 TFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCE---------VPCGGNITSSNGTVYSP 2196

Query: 657  HHPGTFGFNTTCYFGCNAGF---TLIGDSTLSCRPSGQWTAV 695
              P  +  +  C +           +  S L   PSG +  +
Sbjct: 2197 GFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITI 2238



 Score = 38.1 bits (87), Expect = 0.034
 Identities = 20/63 (31%), Positives = 30/63 (47%), Gaps = 8/63 (12%)

Query: 572 CPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVEC----TTSGRWSATPP 627
           CP+   PE+G    SD    F +GS+  F+C+ G+ L+G   + C         WS   P
Sbjct: 343 CPDPGIPERGKRLGSD----FRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRP 398

Query: 628 TCK 630
            C+
Sbjct: 399 VCR 401



 Score = 38.1 bits (87), Expect = 0.034
 Identities = 15/46 (32%), Positives = 21/46 (45%)

Query: 654 YCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPAC 699
           Y R     F    T  F C   F L+G   ++C+ + QW+A  P C
Sbjct: 529 YGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGC 574



 Score = 36.6 bits (83), Expect = 0.098
 Identities = 24/82 (29%), Positives = 35/82 (42%), Gaps = 13/82 (15%)

Query: 591  EFNVGSTCHFSCDNGFKLEGPNNVECT--TSGRWSATPPTCKGIASLPTPGVQCPA--LT 646
            EFN+G    + C  GF L G   + C   T  ++   PP C+         V CP   L 
Sbjct: 2311 EFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICE---------VHCPTNELL 2361

Query: 647  TPGQGTMYCRHHPGTFGFNTTC 668
            T   G +  + +PG++    TC
Sbjct: 2362 TDSTGVILSQSYPGSYPQFQTC 2383



 Score = 34.3 bits (77), Expect = 0.49
 Identities = 63/277 (22%), Positives = 96/277 (34%), Gaps = 67/277 (24%)

Query: 476 FTCNEGLLLVGASVLQCLA----TGNWNSVPPECQAIP-CTPLLSPQNGTMTCVQPLGSS 530
           ++CN G  L G +VL C A    +  W+   P C+A   C   L  Q+G ++   P   S
Sbjct: 163 YSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADDACGGTLRGQSGIIS--SPHFPS 220

Query: 531 SYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPEL-FAPEQGS--LDCSD 587
            Y +                  DCT    WT    + + I    + F  E G   L+ + 
Sbjct: 221 EYHNNA----------------DCT----WTILAELGDTIALVFIDFQLEDGYDFLEVTG 260

Query: 588 TRGE---FNVGST------------CHFSCDNGFKLEG-------PNNVECTTSG-RWSA 624
           T G    F   S              HF+ D   +  G          +E  + G +   
Sbjct: 261 TEGSSLWFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIELKSRGVKLMP 320

Query: 625 TPPTCKGIASLPTPGVQ-----CPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLI 679
           +    +  + L   GV      CP    P +G    +     F   ++  F CN G+ L 
Sbjct: 321 SKDNSQKTSVLTQVGVSQGHNMCPDPGIPERG----KRLGSDFRLGSSVQFTCNEGYDLQ 376

Query: 680 GDSTLSCRPSGQ----WTAVTPACRAVKCSELHVNKP 712
           G   ++C         W+   P CRA  C + H+  P
Sbjct: 377 GSKRITCMKVSDMFAAWSDHRPVCRARMC-DAHLRGP 412



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 16/45 (35%), Positives = 20/45 (44%), Gaps = 4/45 (8%)

Query: 661 TFGFNTTCYFGCNAGFTLIGDSTLSCRP----SGQWTAVTPACRA 701
           TF       + CN GF L G + L+C      S  W    P+CRA
Sbjct: 154 TFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRA 198



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 21/81 (25%), Positives = 30/81 (37%), Gaps = 11/81 (13%)

Query: 592 FNVGSTCHFSCDNGFKLEGPNNVEC----TTSGRWSATPPTCKGIASLPTPGVQCPALTT 647
           FN+G    +SC+ GF LEG   + C      S  W    P+C+   +       C     
Sbjct: 155 FNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADDA-------CGGTLR 207

Query: 648 PGQGTMYCRHHPGTFGFNTTC 668
              G +   H P  +  N  C
Sbjct: 208 GQSGIISSPHFPSEYHNNADC 228



 Score = 30.8 bits (68), Expect = 5.4
 Identities = 13/38 (34%), Positives = 15/38 (39%)

Query: 724 FSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
           F +G    F C     L G     CQ+N  WS   P C
Sbjct: 537 FHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGC 574


>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
          Length = 2489

 Score =  192 bits (488), Expect = 1e-48
 Identities = 163/631 (25%), Positives = 245/631 (38%), Gaps = 79/631 (12%)

Query: 185  CYPGFY--GP---ECEYVRE-------CGELELPQHVLMNCSHPLG---NFSFNSQCSFH 229
            C PGF   GP   +C+ + +       C  +  P   +++  H      NFS   +  + 
Sbjct: 1616 CQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYS 1675

Query: 230  CTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPL--KIPERGNMTCLHSAKAFQHQSS 287
            C  GY + G + L C   G W+ + P+C    C     ++P    +  L+     Q  + 
Sbjct: 1676 CEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLN----LQLGAK 1731

Query: 288  CSFSCEEGFALVGPEVVQCTASGV---WTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAF 344
             SF C+EGF L G  V  C   G+   W    PVC+ + C +  A   G      P    
Sbjct: 1732 VSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGT-PSGDI 1790

Query: 345  AYGSSCKFECQPG------YRVRGLDMLRCIDSGH----WSAPLPTCE----AISCEPLE 390
             YG    + C P       + + G   +RC    H    WS+P P CE    A  C+  E
Sbjct: 1791 PYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPE 1850

Query: 391  SPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQD 450
                 S     +   F   T+ ++ C  G+  +   I   +NL  W++    C+   C  
Sbjct: 1851 QFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENL-VWSSVEDNCRRKSCGP 1909

Query: 451  LPVP--NEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGN---WNSVPPEC 505
             P P      +N    FG     S  +++CNEG  L+G+    CL +GN   W+   P C
Sbjct: 1910 PPEPFNGMVHINTDTQFG-----STVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPIC 1964

Query: 506  QAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEG------YSLSGPERLDCTRS-- 557
            + I C P  +  NG         S    +   + C  G      + L G   + CT    
Sbjct: 1965 EIISCEPPPTISNGDFYSNNRT-SFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDD 2023

Query: 558  --GRWTDSPPMCEAIKCPELFAPE-QGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNV 614
              G W+  PP C  I   +  APE + ++     R  F +     F C  GF + G + V
Sbjct: 2024 QVGVWSSPPPRC--ISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTV 2081

Query: 615  ECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNA 674
            +C T+GRW    P C  +        Q P     G+ T+    H   F      ++ C  
Sbjct: 2082 QCQTNGRWGPKLPHCSRVC-------QPPPEILHGEHTL---SHQDNFSPGQEVFYSCEP 2131

Query: 675  GFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHC 734
             + L G ++L C P G W+   P C    C +     P       L  N   G+  SF C
Sbjct: 2132 SYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPL--NLQLGAKVSFVC 2189

Query: 735  LEGQLLNGSAQTACQENGH---WSTTVPTCQ 762
             EG  L G + + C   G    W+++VP C+
Sbjct: 2190 DEGFRLKGRSASHCVLAGMKALWNSSVPVCE 2220



 Score =  191 bits (484), Expect = 3e-48
 Identities = 165/633 (26%), Positives = 249/633 (39%), Gaps = 65/633 (10%)

Query: 171  QGECLETIGNYTCSCYPGFYG--------PECEYVRECGELELP-QHVLMNCSHPLGNFS 221
            +G     IG  T  C    +G        P CE     G  + P Q    + + P+ +F 
Sbjct: 1806 RGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFE 1865

Query: 222  F--NSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSA 279
            F   +  ++ C  GY       + CL + +W++    C    C P   P  G    +H  
Sbjct: 1866 FPVGTSLNYECRPGY-FGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNG---MVHIN 1921

Query: 280  KAFQHQSSCSFSCEEGFALVGPEVVQCTASG---VWTAPAPVCKAVQCQHLEAPSEGTMD 336
               Q  S+ ++SC EGF L+G     C  SG    W   AP+C+ + C+     S G   
Sbjct: 1922 TDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFY 1981

Query: 337  CVHPLTAFAYGSSCKFECQPG------YRVRGLDMLRCIDS----GHWSAPLPTCEAISC 386
              +  T+F  G+   ++C  G      + + G   + C       G WS+P P C  IS 
Sbjct: 1982 S-NNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRC--IST 2038

Query: 387  EPLESPVHGSMDCSPSLRAFQYDTNC-SFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQA 445
                +P   +    P  R+F   T    FRC  GF++ G+  V+C   G+W    P C  
Sbjct: 2039 NKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSR 2098

Query: 446  LQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPEC 505
            + CQ  P         SH       Q V  ++C     L GA+ L C   G+W+   P C
Sbjct: 2099 V-CQPPPEILHGEHTLSHQDNFSPGQEVF-YSCEPSYDLRGAASLHCTPQGDWSPEAPRC 2156

Query: 506  QAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR---WTD 562
                C   L  Q      + PL +    +   F+CDEG+ L G     C  +G    W  
Sbjct: 2157 TVKSCDDFLG-QLPHGRVLLPL-NLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNS 2214

Query: 563  SPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNG------FKLEGPNNVEC 616
            S P+CE I CP   A   G        G+   G    ++CD        F L G +++ C
Sbjct: 2215 SVPVCEQIFCPNPPAILNGR-HTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRC 2273

Query: 617  TT----SGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGC 672
            T+    +G WS+  P C+   S+P      P +    Q   Y   H   +    T  + C
Sbjct: 2274 TSDPQGNGVWSSPAPRCE--LSVPAACPHPPKI----QNGHYIGGHVSLYLPGMTISYIC 2327

Query: 673  NAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSN----LWGNFSYGS 728
            + G+ L+G   + C   G W+ +   C+ V CS      P+ MN  +    +   + YG 
Sbjct: 2328 DPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCS-----FPLFMNGISKELEMKKVYHYGD 2382

Query: 729  ICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
              +  C +G  L GS  + CQ +  W   +  C
Sbjct: 2383 YVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKC 2415



 Score =  187 bits (476), Expect = 3e-47
 Identities = 175/692 (25%), Positives = 259/692 (37%), Gaps = 137/692 (19%)

Query: 219  NFSFNSQCSFHCTDG------YQVNGPSKLECLAS----GIWTNKPPQCLAA-QCPPLKI 267
            NF + S  ++ C  G      +++ G   + C ++    GIW+   PQC+   +C P  +
Sbjct: 1534 NFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV 1593

Query: 268  PERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHL 327
             E G +    +   F       F C+ GF + GP  V+C A   W    P C  V CQ  
Sbjct: 1594 -ENGILVS-DNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPP 1650

Query: 328  EAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCE 387
                 G     H    F+ G    + C+PGY +RG   L C   G WS   P C   SC+
Sbjct: 1651 PEILHGEHTPSHQ-DNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCD 1709

Query: 388  P-LESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ---WTAPAPVC 443
              L    HG +    +L   Q     SF C EGF L+G+ +  C  +G    W    PVC
Sbjct: 1710 DFLGQLPHGRVLFPLNL---QLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVC 1766

Query: 444  QALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTC----NEGLL--LVGASVLQCLA--- 494
            + + C + P     R +   P G   Y    S+TC    + G+   L+G S ++C +   
Sbjct: 1767 EHIFCPNPPAILNGR-HTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPH 1825

Query: 495  -TGNWNSVPPECQ-------------------AIP---------------CTPLLSPQNG 519
              G W+S  P C+                    IP               C P    +  
Sbjct: 1826 GNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMF 1885

Query: 520  TMTCVQPLGSSSYKSTCQ----------------------------FICDEGYSLSGPER 551
            +++C++ L  SS +  C+                            + C+EG+ L G   
Sbjct: 1886 SISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPS 1945

Query: 552  LDCTRSGR---WTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNG--- 605
              C  SG    W    P+CE I C        G    S+ R  F+ G+   + C  G   
Sbjct: 1946 TTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF-YSNNRTSFHNGTVVTYQCHTGPDG 2004

Query: 606  ---FKLEGPNNVECTTS----GRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHH 658
               F+L G  ++ CT+     G WS+ PP C        P V+  A+  PG  +      
Sbjct: 2005 EQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVE-NAIRVPGNRSF----- 2058

Query: 659  PGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSE----LHVNKPIA 714
               F       F C  GF ++G  T+ C+ +G+W    P C  V C      LH    ++
Sbjct: 2059 ---FTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV-CQPPPEILHGEHTLS 2114

Query: 715  MNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEALTY 774
                    NFS G    + C     L G+A   C   G WS   P C     T++    +
Sbjct: 2115 HQ-----DNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRC-----TVKSCDDF 2164

Query: 775  FG----GAVASTIGLIMGGTLLALLRKRFRQK 802
             G    G V   + L +G  +  +  + FR K
Sbjct: 2165 LGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLK 2196



 Score =  182 bits (463), Expect = 8e-46
 Identities = 160/650 (24%), Positives = 233/650 (35%), Gaps = 135/650 (20%)

Query: 219 NFSFNSQCSFHCTDG------YQVNGPSKLECLAS----GIWTNKPPQCLAA-QCPPLKI 267
           NF + S  ++ C  G      +++ G   + C ++    GIW+   PQC+   +C P  +
Sbjct: 184 NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV 243

Query: 268 PERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQ-- 325
            E G +    +   F       F C+ GF + GP  V+C A   W    P C  V CQ  
Sbjct: 244 -ENGILVS-DNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPP 300

Query: 326 ----HLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC 381
               H E       +       F+ G    + C+PGY +RG   +RC   G WS   PTC
Sbjct: 301 PDVLHAERTQRDKDN-------FSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 353

Query: 382 EAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ---WTA 438
           E  SC+     +       P     Q      F C EGF L+G+    C   G    W +
Sbjct: 354 EVKSCDDFMGQLLNGRVLFPV--NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS 411

Query: 439 PAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNE------GLLLVGASVLQC 492
             PVC+ + C   PV    R +   P   F +    ++TC+          L+G S ++C
Sbjct: 412 SVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRC 470

Query: 493 LA----TGNWNSVPPECQAI-------------------------------PCTPLLSPQ 517
            +     G W+S  P C  +                                C P    +
Sbjct: 471 TSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGR 530

Query: 518 NGTMTCVQPLGSSSYKSTCQ----------------------------FICDEGYSLSGP 549
             ++TC+  L  SS K  C+                            + C  G+ L G 
Sbjct: 531 PFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH 590

Query: 550 ERLDCTRSGR---WTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNG- 605
              +C  SG    W+  PP+C+ I C        G    S  R  F+ GS   + C+ G 
Sbjct: 591 SSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF-ISTNRENFHYGSVVTYRCNPGS 649

Query: 606 -----FKLEGPNNVECTTS----GRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCR 656
                F+L G  ++ CT++    G WS   P C        P V+   L +  +      
Sbjct: 650 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL---- 705

Query: 657 HHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSE----LHVNKP 712
                F  N    F C  GF + G   + C+   +W    P+C  V C      LH  + 
Sbjct: 706 -----FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERT 759

Query: 713 IAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762
                     NFS G    + C  G  L G+A   C   G WS   PTC+
Sbjct: 760 QRDK-----DNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE 804



 Score =  182 bits (463), Expect = 8e-46
 Identities = 160/650 (24%), Positives = 233/650 (35%), Gaps = 135/650 (20%)

Query: 219  NFSFNSQCSFHCTDG------YQVNGPSKLECLAS----GIWTNKPPQCLAA-QCPPLKI 267
            NF + S  ++ C  G      +++ G   + C ++    GIW+   PQC+   +C P  +
Sbjct: 634  NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV 693

Query: 268  PERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQ-- 325
             E G +    +   F       F C+ GF + GP  V+C A   W    P C  V CQ  
Sbjct: 694  -ENGILVS-DNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPP 750

Query: 326  ----HLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC 381
                H E       +       F+ G    + C+PGY +RG   +RC   G WS   PTC
Sbjct: 751  PDVLHAERTQRDKDN-------FSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 803

Query: 382  EAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ---WTA 438
            E  SC+     +       P     Q      F C EGF L+G+    C   G    W +
Sbjct: 804  EVKSCDDFMGQLLNGRVLFPV--NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS 861

Query: 439  PAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNE------GLLLVGASVLQC 492
              PVC+ + C   PV    R +   P   F +    ++TC+          L+G S ++C
Sbjct: 862  SVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRC 920

Query: 493  LA----TGNWNSVPPECQAI-------------------------------PCTPLLSPQ 517
             +     G W+S  P C  +                                C P    +
Sbjct: 921  TSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGR 980

Query: 518  NGTMTCVQPLGSSSYKSTCQ----------------------------FICDEGYSLSGP 549
              ++TC+  L  SS K  C+                            + C  G+ L G 
Sbjct: 981  PFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH 1040

Query: 550  ERLDCTRSGR---WTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNG- 605
               +C  SG    W+  PP+C+ I C        G    S  R  F+ GS   + C+ G 
Sbjct: 1041 SSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF-ISTNRENFHYGSVVTYRCNPGS 1099

Query: 606  -----FKLEGPNNVECTTS----GRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCR 656
                 F+L G  ++ CT++    G WS   P C        P V+   L +  +      
Sbjct: 1100 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL---- 1155

Query: 657  HHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSE----LHVNKP 712
                 F  N    F C  GF + G   + C+   +W    P+C  V C      LH  + 
Sbjct: 1156 -----FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERT 1209

Query: 713  IAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762
                      NFS G    + C  G  L G+A   C   G WS   PTC+
Sbjct: 1210 QRDK-----DNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE 1254



 Score =  178 bits (451), Expect = 2e-44
 Identities = 159/649 (24%), Positives = 232/649 (35%), Gaps = 135/649 (20%)

Query: 219  NFSFNSQCSFHCTDG------YQVNGPSKLECLAS----GIWTNKPPQCLAA-QCPPLKI 267
            NF + S  ++ C  G      +++ G   + C ++    GIW+   PQC+   +C P  +
Sbjct: 1084 NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV 1143

Query: 268  PERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQ-- 325
             E G +    +   F       F C+ GF + GP  V+C A   W    P C  V CQ  
Sbjct: 1144 -ENGILVS-DNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPP 1200

Query: 326  ----HLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC 381
                H E       +       F+ G    + C+PGY +RG   +RC   G WS   PTC
Sbjct: 1201 PDVLHAERTQRDKDN-------FSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 1253

Query: 382  EAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ---WTA 438
            E  SC+     +       P     Q      F C EGF L+G+    C   G    W +
Sbjct: 1254 EVKSCDDFMGQLLNGRVLFPV--NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS 1311

Query: 439  PAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCN------EGLLLVGASVLQC 492
              PVC+ + C   PV    R +   P   F +    ++TC+          L+G S ++C
Sbjct: 1312 SVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRC 1370

Query: 493  LA----TGNWNSVPPECQAI-------------------------------PCTPLLSPQ 517
             +     G W+S  P C  +                                C P    +
Sbjct: 1371 TSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGR 1430

Query: 518  NGTMTCVQPLGSSSYKSTCQ----------------------------FICDEGYSLSGP 549
              ++TC+  L  SS K  C+                            + C  G+ L G 
Sbjct: 1431 PFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH 1490

Query: 550  ERLDCTRSG---RWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNG- 605
               +C  SG    W+  PP+C+ I C        G    S  R  F+ GS   + C+ G 
Sbjct: 1491 SSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF-ISTNRENFHYGSVVTYRCNLGS 1549

Query: 606  -----FKLEGPNNVECTTS----GRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCR 656
                 F+L G  ++ CT++    G WS   P C        P V+   L +  +      
Sbjct: 1550 RGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNR------ 1603

Query: 657  HHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSE----LHVNKP 712
                 F  N    F C  GF + G   + C+   +W    P+C  V C      LH    
Sbjct: 1604 ---SLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPEILH---- 1655

Query: 713  IAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
               +  +   NFS G    + C  G  L G+A   C   G WS   P C
Sbjct: 1656 -GEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1703



 Score =  176 bits (446), Expect = 8e-44
 Identities = 157/596 (26%), Positives = 242/596 (40%), Gaps = 75/596 (12%)

Query: 215  HPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASG---IWTNKPPQCLAAQCPPLKIPERG 271
            H + +    S+ ++ CT G+++ G S  EC+ SG    W+ KPP C    C        G
Sbjct: 1466 HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANG 1525

Query: 272  NMTCLHSAKAFQHQSSCSFSCEEG------FALVGPEVVQCTAS----GVWTAPAPVCKA 321
            +     + + F + S  ++ C  G      F LVG   + CT++    G+W+ PAP C  
Sbjct: 1526 DFIST-NRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC-I 1583

Query: 322  VQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC 381
            +  +      E  +      + F+     +F CQPG+ ++G   ++C     W   LP+C
Sbjct: 1584 IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 1643

Query: 382  EAISCEPLESPVHGSMDCSPSLR-AFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPA 440
              + C+P    +HG  + +PS +  F       + C  G+ LRGA  + C   G W+  A
Sbjct: 1644 SRV-CQPPPEILHG--EHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEA 1700

Query: 441  PVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGN--- 497
            P C    C D  +          P    +  +  SF C+EG  L G+SV  C+  G    
Sbjct: 1701 PRCAVKSCDDF-LGQLPHGRVLFPLN-LQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSL 1758

Query: 498  WNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDE------GYSLSGPER 551
            WN+  P C+ I C    +  NG  T   P G   Y     + CD        ++L G   
Sbjct: 1759 WNNSVPVCEHIFCPNPPAILNGRHTGT-PSGDIPYGKEISYTCDPHPDRGMTFNLIGEST 1817

Query: 552  LDCTR----SGRWTDSPPMCEA------IKCPELFAPEQGSLDCSDTRGEFNVGSTCHFS 601
            + CT     +G W+   P CE        K PE F     ++  +D   EF VG++ ++ 
Sbjct: 1818 IRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLNYE 1875

Query: 602  CDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGT 661
            C  G+      ++ C  +  WS+    C+  +  P P         P  G +   H    
Sbjct: 1876 CRPGY-FGKMFSISCLENLVWSSVEDNCRRKSCGPPP--------EPFNGMV---HINTD 1923

Query: 662  FGFNTTCYFGCNAGFTLIGDSTLSCRPSGQ---WTAVTPACRAVKCSELHVNKPIAMN-- 716
              F +T  + CN GF LIG  + +C  SG    W    P C  + C       P   N  
Sbjct: 1924 TQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEP----PPTISNGD 1979

Query: 717  -CSNLWGNFSYGSICSFHCLEG----QL--LNGSAQTAC----QENGHWSTTVPTC 761
              SN   +F  G++ ++ C  G    QL  L G     C     + G WS+  P C
Sbjct: 1980 FYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRC 2035



 Score =  175 bits (443), Expect = 2e-43
 Identities = 171/677 (25%), Positives = 269/677 (39%), Gaps = 116/677 (17%)

Query: 184  SCYPGF--YGPECEYVRECGEL--ELPQHVLMNCSHPLG-----------NFSFNSQCSF 228
            SC PG+   G    +    G+   E P+  + +C   LG           N    ++ SF
Sbjct: 1675 SCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSF 1734

Query: 229  HCTDGYQVNGPSKLECLASG---IWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQ 285
             C +G+++ G S   C+  G   +W N  P C    CP       G  T   S     + 
Sbjct: 1735 VCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGD-IPYG 1793

Query: 286  SSCSFSCEEG------FALVGPEVVQCTA----SGVWTAPAPVCK-AVQCQHLEAPSEGT 334
               S++C+        F L+G   ++CT+    +GVW++PAP C+ +V+  H + P +  
Sbjct: 1794 KEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFP 1853

Query: 335  MDC-VHPLTAFAY--GSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLES 391
                  P+  F +  G+S  +EC+PGY  + +  + C+++  WS+    C   SC P   
Sbjct: 1854 FASPTIPINDFEFPVGTSLNYECRPGYFGK-MFSISCLENLVWSSVEDNCRRKSCGPPPE 1912

Query: 392  PVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRC---DNLGQWTAPAPVCQALQC 448
            P +G +  +      Q+ +  ++ C EGF L G+    C    N   W   AP+C+ + C
Sbjct: 1913 PFNGMVHINTDT---QFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISC 1969

Query: 449  QDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEG------LLLVGASVLQCLA----TGNW 498
            +  P  +      S+   +F   +V ++ C+ G        LVG   + C +     G W
Sbjct: 1970 EPPPTISNGDFY-SNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVW 2028

Query: 499  NSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFI---CDEGYSLSGPERLDCT 555
            +S PP C  I      +P+      ++  G+ S+ +  + I   C  G+ + G   + C 
Sbjct: 2029 SSPPPRC--ISTNKCTAPE--VENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQ 2084

Query: 556  RSGRWTDSPPMCEAIKC---PELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPN 612
             +GRW    P C  + C   PE+   E  +L   D    F+ G    +SC+  + L G  
Sbjct: 2085 TNGRWGPKLPHCSRV-CQPPPEILHGEH-TLSHQDN---FSPGQEVFYSCEPSYDLRGAA 2139

Query: 613  NVECTTSGRWSATPPTCKG------IASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNT 666
            ++ CT  G WS   P C        +  LP   V  P     G                 
Sbjct: 2140 SLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVS------------- 2186

Query: 667  TCYFGCNAGFTLIGDSTLSCRPSGQ---WTAVTPACRAVKCSELHVNKPIAMNCSNL--- 720
               F C+ GF L G S   C  +G    W +  P C  + C     N P  +N  +    
Sbjct: 2187 ---FVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCP----NPPAILNGRHTGTP 2239

Query: 721  WGNFSYGS----ICSFHCLEGQLLN--GSAQTAC----QENGHWSTTVPTCQAG------ 764
            +G+  YG      C  H   G   N  G +   C    Q NG WS+  P C+        
Sbjct: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACP 2299

Query: 765  -PLTIQEALTYFGGAVA 780
             P  IQ    Y GG V+
Sbjct: 2300 HPPKIQNG-HYIGGHVS 2315



 Score =  171 bits (433), Expect = 3e-42
 Identities = 170/735 (23%), Positives = 273/735 (37%), Gaps = 181/735 (24%)

Query: 192  PECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASG--- 248
            P CE V+ C +  + Q +      P+ N    ++  F C +G+Q+ G S   C+ +G   
Sbjct: 351  PTCE-VKSCDDF-MGQLLNGRVLFPV-NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMES 407

Query: 249  IWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEE------GFALVGPE 302
            +W +  P C    CP   +   G  T     + F    + +++C+        F L+G  
Sbjct: 408  LWNSSVPVCEQIFCPSPPVIPNGRHTG-KPLEVFPFGKTVNYTCDPHPDRGTSFDLIGES 466

Query: 303  VVQCTA----SGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTA---FAYGSSCKFECQ 355
             ++CT+    +GVW++PAP C  +   H +AP       +   T    F  G+S K+EC+
Sbjct: 467  TIRCTSDPQGNGVWSSPAPRCGILG--HCQAPDHFLFAKLKTQTNASDFPIGTSLKYECR 524

Query: 356  PGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFR 415
            P Y  R    + C+D+  WS+P   C+  SC+    PV+G +     +   Q  +  ++ 
Sbjct: 525  PEYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDI---QVGSRINYS 580

Query: 416  CAEGFMLRGADIVRC---DNLGQWTAPAPVCQALQCQDLP-VPNEARVNCSHPFGAFRYQ 471
            C  G  L G     C    N   W+   P+CQ + C   P + N   ++ +     F Y 
Sbjct: 581  CTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRE--NFHYG 638

Query: 472  SVCSFTCNEG------LLLVGASVLQCLAT----GNWNSVPPECQAIP--CTPLLSPQNG 519
            SV ++ CN G        LVG   + C +     G W+   P+C  IP  CTP  + +NG
Sbjct: 639  SVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC-IIPNKCTPP-NVENG 696

Query: 520  TMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKC---PELF 576
             +         S     +F C  G+ + GP R+ C    +W    P C  + C   P++ 
Sbjct: 697  ILVS-DNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVL 754

Query: 577  APEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCK------ 630
              E+   D    +  F+ G    +SC+ G+ L G  ++ CT  G WS   PTC+      
Sbjct: 755  HAERTQRD----KDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDD 810

Query: 631  -------------------------------------------GIASLPTPGVQ-CPALT 646
                                                       G+ SL    V  C  + 
Sbjct: 811  FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF 870

Query: 647  TPGQGTMYCRHHPG----TFGFNTTCYFGCN------AGFTLIGDSTLSC----RPSGQW 692
             P    +    H G     F F  T  + C+        F LIG+ST+ C    + +G W
Sbjct: 871  CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVW 930

Query: 693  TAVTPACRAV-------------------------------KCSELHVNKPIAMNCSN-- 719
            ++  P C  +                               +C   +  +P ++ C +  
Sbjct: 931  SSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNL 990

Query: 720  LWGN--------------------------FSYGSICSFHCLEGQLLNGSAQTACQENG- 752
            +W +                             GS  ++ C  G  L G +   C  +G 
Sbjct: 991  VWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGN 1050

Query: 753  --HWSTTVPTCQAGP 765
              HWST  P CQ  P
Sbjct: 1051 AAHWSTKPPICQRIP 1065



 Score =  169 bits (429), Expect = 7e-42
 Identities = 156/601 (25%), Positives = 234/601 (38%), Gaps = 88/601 (14%)

Query: 215 HPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASG---IWTNKPPQCLAAQCPPLKIPERG 271
           H +    F SQ  + CT GY++ G S   C+ SG   IW N+ P C    C        G
Sbjct: 116 HVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNG 175

Query: 272 NMTCLHSAKAFQHQSSCSFSCEEG------FALVGPEVVQCTAS----GVWTAPAPVCKA 321
           +     + + F + S  ++ C  G      F LVG   + CT++    G+W+ PAP C  
Sbjct: 176 DFIST-NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC-I 233

Query: 322 VQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC 381
           +  +      E  +      + F+     +F CQPG+ ++G   ++C     W   LP+C
Sbjct: 234 IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 293

Query: 382 EAISCEPLESPVHGSM------DCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ 435
             + C+P    +H         + SP    F       + C  G+ LRGA  +RC   G 
Sbjct: 294 SRV-CQPPPDVLHAERTQRDKDNFSPGQEVF-------YSCEPGYDLRGAASMRCTPQGD 345

Query: 436 WTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLAT 495
           W+  AP C+   C D  +          P    +  +   F C+EG  L G+S   C+  
Sbjct: 346 WSPAAPTCEVKSCDDF-MGQLLNGRVLFPVN-LQLGAKVDFVCDEGFQLKGSSASYCVLA 403

Query: 496 GN---WNSVPPECQAIPC-TPLLSPQNGTMTCVQPLGSSSYKSTCQFICD------EGYS 545
           G    WNS  P C+ I C +P + P NG  T  +PL    +  T  + CD        + 
Sbjct: 404 GMESLWNSSVPVCEQIFCPSPPVIP-NGRHT-GKPLEVFPFGKTVNYTCDPHPDRGTSFD 461

Query: 546 LSGPERLDCTR----SGRWTDSPPMCEAI---KCPE--LFAPEQGSLDCSDTRGEFNVGS 596
           L G   + CT     +G W+   P C  +   + P+  LFA  +   + SD    F +G+
Sbjct: 462 LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD----FPIGT 517

Query: 597 TCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCR 656
           +  + C   +    P ++ C  +  WS+    CK           C     P  G +   
Sbjct: 518 SLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCK--------RKSCKTPPDPVNGMV--- 565

Query: 657 HHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSG---QWTAVTPACRAVKCSELHVNKPI 713
           H        +   + C  G  LIG S+  C  SG    W+   P C+ + C       P 
Sbjct: 566 HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCG----LPPT 621

Query: 714 AMN---CSNLWGNFSYGSICSFHCLEGQ------LLNGSAQTACQEN----GHWSTTVPT 760
             N    S    NF YGS+ ++ C  G        L G     C  N    G WS   P 
Sbjct: 622 IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 681

Query: 761 C 761
           C
Sbjct: 682 C 682



 Score =  165 bits (417), Expect = 2e-40
 Identities = 143/578 (24%), Positives = 219/578 (37%), Gaps = 57/578 (9%)

Query: 220 FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSA 279
           F   +  ++ C  GY    P  + CL + +WT    +C    C     P  G    +H  
Sbjct: 63  FPIGTYLNYECRPGYS-GRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNG---MVHVI 118

Query: 280 KAFQHQSSCSFSCEEGFALVGPEVVQCTASG---VWTAPAPVCKAVQCQHLEAPSEGTMD 336
           K  Q  S   +SC +G+ L+G     C  SG   +W    P+C  + C      + G   
Sbjct: 119 KGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFI 178

Query: 337 CVHPLTAFAYGSSCKFECQPG------YRVRGLDMLRCIDS----GHWSAPLPTCEAIS- 385
             +    F YGS   + C PG      + + G   + C  +    G WS P P C   + 
Sbjct: 179 STN-RENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 237

Query: 386 CEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQA 445
           C P    V   +  S +   F  +    FRC  GF+++G   V+C  L +W    P C  
Sbjct: 238 CTP--PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR 295

Query: 446 LQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPEC 505
           + CQ  P    A          F       ++C  G  L GA+ ++C   G+W+   P C
Sbjct: 296 V-CQPPPDVLHAE-RTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 353

Query: 506 QAIPCTPLLSP-QNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR---WT 561
           +   C   +    NG +     L      +   F+CDEG+ L G     C  +G    W 
Sbjct: 354 EVKSCDDFMGQLLNGRVLFPVNL---QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWN 410

Query: 562 DSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCD------NGFKLEGPNNVE 615
            S P+CE I CP       G          F  G T +++CD        F L G + + 
Sbjct: 411 SSVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIR 469

Query: 616 CTT----SGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFG 671
           CT+    +G WS+  P C GI         C A        +  + +   F   T+  + 
Sbjct: 470 CTSDPQGNGVWSSPAPRC-GILG------HCQAPDHFLFAKLKTQTNASDFPIGTSLKYE 522

Query: 672 CNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMN-CSNLWGNFSYGSIC 730
           C   +      +++C  +  W++    C+   C       P  +N   ++  +   GS  
Sbjct: 523 CRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCK----TPPDPVNGMVHVITDIQVGSRI 577

Query: 731 SFHCLEGQLLNGSAQTACQENG---HWSTTVPTCQAGP 765
           ++ C  G  L G +   C  +G   HWST  P CQ  P
Sbjct: 578 NYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIP 615



 Score =  156 bits (394), Expect = 9e-38
 Identities = 150/653 (22%), Positives = 235/653 (35%), Gaps = 126/653 (19%)

Query: 216  PLGNFSFNSQCSFHCTD------GYQVNGPSKLECLA----SGIWTNKPPQC-LAAQCPP 264
            PL  F F    ++ C         + + G S + C +    +G+W++  P+C +   C  
Sbjct: 886  PLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQA 945

Query: 265  LKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQC 324
                    +    +A  F   +S  + C   +    P  + C  + VW++P  VCK   C
Sbjct: 946  PDHFLFAKLKTQTNASDFPIGTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSC 1004

Query: 325  QHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSG---HWSAPLPTC 381
            +    P  G    VH +T    GS   + C  G+R+ G     CI SG   HWS   P C
Sbjct: 1005 KTPPDPVNGM---VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPIC 1061

Query: 382  EAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEG------FMLRGADIVRC----D 431
            + I C    +  +G    S +   F Y +  ++RC  G      F L G   + C    D
Sbjct: 1062 QRIPCGLPPTIANGDF-ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 1120

Query: 432  NLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQ 491
             +G W+ PAP C  +  +  P   E  +  S     F    V  F C  G ++ G   ++
Sbjct: 1121 QVGIWSGPAPQC-IIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 1179

Query: 492  CLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPER 551
            C A   W    P C  + C P     +   T  +   + S      + C+ GY L G   
Sbjct: 1180 CQALNKWEPELPSCSRV-CQPPPDVLHAERT-QRDKDNFSPGQEVFYSCEPGYDLRGAAS 1237

Query: 552  LDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGP 611
            + CT  G W+ + P CE   C +                   +G+   F CD GF+L+G 
Sbjct: 1238 MRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGS 1295

Query: 612  NNVECTTSGR---WSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPG----TFGF 664
            +   C  +G    W+++ P C+ I         CP+      G      H G     F F
Sbjct: 1296 SASYCVLAGMESLWNSSVPVCEQIF--------CPSPPVIPNG-----RHTGKPLEVFPF 1342

Query: 665  NTTCYFGCN------AGFTLIGDSTLSC----RPSGQWTAVTPACRAV------------ 702
                 + C+        F LIG+ST+ C    + +G W++  P C  +            
Sbjct: 1343 GKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFA 1402

Query: 703  -------------------KCSELHVNKPIAMNCSN--LWGN------------------ 723
                               +C   +  +P ++ C +  +W +                  
Sbjct: 1403 KLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVN 1462

Query: 724  --------FSYGSICSFHCLEGQLLNGSAQTACQENG---HWSTTVPTCQAGP 765
                       GS  ++ C  G  L G +   C  +G   HWST  P CQ  P
Sbjct: 1463 GMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIP 1515



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 82/337 (24%), Positives = 120/337 (35%), Gaps = 42/337 (12%)

Query: 443 CQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVP 502
           C A +      P         P G +      ++ C  G      S++ CL    W    
Sbjct: 43  CNAPEWLPFARPTNLTDEFEFPIGTY-----LNYECRPGYSGRPFSII-CLKNSVWTGAK 96

Query: 503 PECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR--- 559
             C+   C     P NG +  ++ +    + S  ++ C +GY L G     C  SG    
Sbjct: 97  DRCRRKSCRNPPDPVNGMVHVIKGI---QFGSQIKYSCTKGYRLIGSSSATCIISGDTVI 153

Query: 560 WTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNG------FKLEGPNN 613
           W +  P+C+ I C        G    S  R  F+ GS   + C+ G      F+L G  +
Sbjct: 154 WDNETPICDRIPCGLPPTITNGDF-ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPS 212

Query: 614 VECTTS----GRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCY 669
           + CT++    G WS   P C        P V+   L +  +           F  N    
Sbjct: 213 IYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL---------FSLNEVVE 263

Query: 670 FGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSE----LHVNKPIAMNCSNLWGNFS 725
           F C  GF + G   + C+   +W    P+C  V C      LH  +           NFS
Sbjct: 264 FRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDK-----DNFS 317

Query: 726 YGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762
            G    + C  G  L G+A   C   G WS   PTC+
Sbjct: 318 PGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE 354


>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
          Length = 2039

 Score =  192 bits (488), Expect = 1e-48
 Identities = 163/631 (25%), Positives = 245/631 (38%), Gaps = 79/631 (12%)

Query: 185  CYPGFY--GP---ECEYVRE-------CGELELPQHVLMNCSHPLG---NFSFNSQCSFH 229
            C PGF   GP   +C+ + +       C  +  P   +++  H      NFS   +  + 
Sbjct: 1166 CQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYS 1225

Query: 230  CTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPL--KIPERGNMTCLHSAKAFQHQSS 287
            C  GY + G + L C   G W+ + P+C    C     ++P    +  L+     Q  + 
Sbjct: 1226 CEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLN----LQLGAK 1281

Query: 288  CSFSCEEGFALVGPEVVQCTASGV---WTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAF 344
             SF C+EGF L G  V  C   G+   W    PVC+ + C +  A   G      P    
Sbjct: 1282 VSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGT-PSGDI 1340

Query: 345  AYGSSCKFECQPG------YRVRGLDMLRCIDSGH----WSAPLPTCE----AISCEPLE 390
             YG    + C P       + + G   +RC    H    WS+P P CE    A  C+  E
Sbjct: 1341 PYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPE 1400

Query: 391  SPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQD 450
                 S     +   F   T+ ++ C  G+  +   I   +NL  W++    C+   C  
Sbjct: 1401 QFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENL-VWSSVEDNCRRKSCGP 1459

Query: 451  LPVP--NEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGN---WNSVPPEC 505
             P P      +N    FG     S  +++CNEG  L+G+    CL +GN   W+   P C
Sbjct: 1460 PPEPFNGMVHINTDTQFG-----STVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPIC 1514

Query: 506  QAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEG------YSLSGPERLDCTRS-- 557
            + I C P  +  NG         S    +   + C  G      + L G   + CT    
Sbjct: 1515 EIISCEPPPTISNGDFYSNNRT-SFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDD 1573

Query: 558  --GRWTDSPPMCEAIKCPELFAPE-QGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNV 614
              G W+  PP C  I   +  APE + ++     R  F +     F C  GF + G + V
Sbjct: 1574 QVGVWSSPPPRC--ISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTV 1631

Query: 615  ECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNA 674
            +C T+GRW    P C  +        Q P     G+ T+    H   F      ++ C  
Sbjct: 1632 QCQTNGRWGPKLPHCSRVC-------QPPPEILHGEHTL---SHQDNFSPGQEVFYSCEP 1681

Query: 675  GFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHC 734
             + L G ++L C P G W+   P C    C +     P       L  N   G+  SF C
Sbjct: 1682 SYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPL--NLQLGAKVSFVC 1739

Query: 735  LEGQLLNGSAQTACQENGH---WSTTVPTCQ 762
             EG  L G + + C   G    W+++VP C+
Sbjct: 1740 DEGFRLKGRSASHCVLAGMKALWNSSVPVCE 1770



 Score =  191 bits (484), Expect = 3e-48
 Identities = 165/633 (26%), Positives = 249/633 (39%), Gaps = 65/633 (10%)

Query: 171  QGECLETIGNYTCSCYPGFYG--------PECEYVRECGELELP-QHVLMNCSHPLGNFS 221
            +G     IG  T  C    +G        P CE     G  + P Q    + + P+ +F 
Sbjct: 1356 RGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFE 1415

Query: 222  F--NSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSA 279
            F   +  ++ C  GY       + CL + +W++    C    C P   P  G    +H  
Sbjct: 1416 FPVGTSLNYECRPGY-FGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNG---MVHIN 1471

Query: 280  KAFQHQSSCSFSCEEGFALVGPEVVQCTASG---VWTAPAPVCKAVQCQHLEAPSEGTMD 336
               Q  S+ ++SC EGF L+G     C  SG    W   AP+C+ + C+     S G   
Sbjct: 1472 TDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFY 1531

Query: 337  CVHPLTAFAYGSSCKFECQPG------YRVRGLDMLRCIDS----GHWSAPLPTCEAISC 386
              +  T+F  G+   ++C  G      + + G   + C       G WS+P P C  IS 
Sbjct: 1532 S-NNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRC--IST 1588

Query: 387  EPLESPVHGSMDCSPSLRAFQYDTNC-SFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQA 445
                +P   +    P  R+F   T    FRC  GF++ G+  V+C   G+W    P C  
Sbjct: 1589 NKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSR 1648

Query: 446  LQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPEC 505
            + CQ  P         SH       Q V  ++C     L GA+ L C   G+W+   P C
Sbjct: 1649 V-CQPPPEILHGEHTLSHQDNFSPGQEVF-YSCEPSYDLRGAASLHCTPQGDWSPEAPRC 1706

Query: 506  QAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR---WTD 562
                C   L  Q      + PL +    +   F+CDEG+ L G     C  +G    W  
Sbjct: 1707 TVKSCDDFLG-QLPHGRVLLPL-NLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNS 1764

Query: 563  SPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNG------FKLEGPNNVEC 616
            S P+CE I CP   A   G        G+   G    ++CD        F L G +++ C
Sbjct: 1765 SVPVCEQIFCPNPPAILNGR-HTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRC 1823

Query: 617  TT----SGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGC 672
            T+    +G WS+  P C+   S+P      P +    Q   Y   H   +    T  + C
Sbjct: 1824 TSDPQGNGVWSSPAPRCE--LSVPAACPHPPKI----QNGHYIGGHVSLYLPGMTISYIC 1877

Query: 673  NAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSN----LWGNFSYGS 728
            + G+ L+G   + C   G W+ +   C+ V CS      P+ MN  +    +   + YG 
Sbjct: 1878 DPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCS-----FPLFMNGISKELEMKKVYHYGD 1932

Query: 729  ICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
              +  C +G  L GS  + CQ +  W   +  C
Sbjct: 1933 YVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKC 1965



 Score =  187 bits (476), Expect = 3e-47
 Identities = 175/692 (25%), Positives = 259/692 (37%), Gaps = 137/692 (19%)

Query: 219  NFSFNSQCSFHCTDG------YQVNGPSKLECLAS----GIWTNKPPQCLAA-QCPPLKI 267
            NF + S  ++ C  G      +++ G   + C ++    GIW+   PQC+   +C P  +
Sbjct: 1084 NFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV 1143

Query: 268  PERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHL 327
             E G +    +   F       F C+ GF + GP  V+C A   W    P C  V CQ  
Sbjct: 1144 -ENGILVS-DNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPP 1200

Query: 328  EAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCE 387
                 G     H    F+ G    + C+PGY +RG   L C   G WS   P C   SC+
Sbjct: 1201 PEILHGEHTPSHQ-DNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCD 1259

Query: 388  P-LESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ---WTAPAPVC 443
              L    HG +    +L   Q     SF C EGF L+G+ +  C  +G    W    PVC
Sbjct: 1260 DFLGQLPHGRVLFPLNL---QLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVC 1316

Query: 444  QALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTC----NEGLL--LVGASVLQCLA--- 494
            + + C + P     R +   P G   Y    S+TC    + G+   L+G S ++C +   
Sbjct: 1317 EHIFCPNPPAILNGR-HTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPH 1375

Query: 495  -TGNWNSVPPECQ-------------------AIP---------------CTPLLSPQNG 519
              G W+S  P C+                    IP               C P    +  
Sbjct: 1376 GNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMF 1435

Query: 520  TMTCVQPLGSSSYKSTCQ----------------------------FICDEGYSLSGPER 551
            +++C++ L  SS +  C+                            + C+EG+ L G   
Sbjct: 1436 SISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPS 1495

Query: 552  LDCTRSGR---WTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNG--- 605
              C  SG    W    P+CE I C        G    S+ R  F+ G+   + C  G   
Sbjct: 1496 TTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDF-YSNNRTSFHNGTVVTYQCHTGPDG 1554

Query: 606  ---FKLEGPNNVECTTS----GRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHH 658
               F+L G  ++ CT+     G WS+ PP C        P V+  A+  PG  +      
Sbjct: 1555 EQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVE-NAIRVPGNRSF----- 1608

Query: 659  PGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSE----LHVNKPIA 714
               F       F C  GF ++G  T+ C+ +G+W    P C  V C      LH    ++
Sbjct: 1609 ---FTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV-CQPPPEILHGEHTLS 1664

Query: 715  MNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEALTY 774
                    NFS G    + C     L G+A   C   G WS   P C     T++    +
Sbjct: 1665 HQ-----DNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRC-----TVKSCDDF 1714

Query: 775  FG----GAVASTIGLIMGGTLLALLRKRFRQK 802
             G    G V   + L +G  +  +  + FR K
Sbjct: 1715 LGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLK 1746



 Score =  182 bits (463), Expect = 8e-46
 Identities = 160/650 (24%), Positives = 233/650 (35%), Gaps = 135/650 (20%)

Query: 219 NFSFNSQCSFHCTDG------YQVNGPSKLECLAS----GIWTNKPPQCLAA-QCPPLKI 267
           NF + S  ++ C  G      +++ G   + C ++    GIW+   PQC+   +C P  +
Sbjct: 184 NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV 243

Query: 268 PERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQ-- 325
            E G +    +   F       F C+ GF + GP  V+C A   W    P C  V CQ  
Sbjct: 244 -ENGILVS-DNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPP 300

Query: 326 ----HLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC 381
               H E       +       F+ G    + C+PGY +RG   +RC   G WS   PTC
Sbjct: 301 PDVLHAERTQRDKDN-------FSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 353

Query: 382 EAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ---WTA 438
           E  SC+     +       P     Q      F C EGF L+G+    C   G    W +
Sbjct: 354 EVKSCDDFMGQLLNGRVLFPV--NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS 411

Query: 439 PAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNE------GLLLVGASVLQC 492
             PVC+ + C   PV    R +   P   F +    ++TC+          L+G S ++C
Sbjct: 412 SVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRC 470

Query: 493 LA----TGNWNSVPPECQAI-------------------------------PCTPLLSPQ 517
            +     G W+S  P C  +                                C P    +
Sbjct: 471 TSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGR 530

Query: 518 NGTMTCVQPLGSSSYKSTCQ----------------------------FICDEGYSLSGP 549
             ++TC+  L  SS K  C+                            + C  G+ L G 
Sbjct: 531 PFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH 590

Query: 550 ERLDCTRSGR---WTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNG- 605
              +C  SG    W+  PP+C+ I C        G    S  R  F+ GS   + C+ G 
Sbjct: 591 SSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDF-ISTNRENFHYGSVVTYRCNPGS 649

Query: 606 -----FKLEGPNNVECTTS----GRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCR 656
                F+L G  ++ CT++    G WS   P C        P V+   L +  +      
Sbjct: 650 GGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL---- 705

Query: 657 HHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSE----LHVNKP 712
                F  N    F C  GF + G   + C+   +W    P+C  V C      LH  + 
Sbjct: 706 -----FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERT 759

Query: 713 IAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762
                     NFS G    + C  G  L G+A   C   G WS   PTC+
Sbjct: 760 QRDK-----DNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE 804



 Score =  178 bits (451), Expect = 2e-44
 Identities = 159/649 (24%), Positives = 232/649 (35%), Gaps = 135/649 (20%)

Query: 219  NFSFNSQCSFHCTDG------YQVNGPSKLECLAS----GIWTNKPPQCLAA-QCPPLKI 267
            NF + S  ++ C  G      +++ G   + C ++    GIW+   PQC+   +C P  +
Sbjct: 634  NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNV 693

Query: 268  PERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQ-- 325
             E G +    +   F       F C+ GF + GP  V+C A   W    P C  V CQ  
Sbjct: 694  -ENGILVS-DNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPP 750

Query: 326  ----HLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC 381
                H E       +       F+ G    + C+PGY +RG   +RC   G WS   PTC
Sbjct: 751  PDVLHAERTQRDKDN-------FSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 803

Query: 382  EAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ---WTA 438
            E  SC+     +       P     Q      F C EGF L+G+    C   G    W +
Sbjct: 804  EVKSCDDFMGQLLNGRVLFPV--NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS 861

Query: 439  PAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCN------EGLLLVGASVLQC 492
              PVC+ + C   PV    R +   P   F +    ++TC+          L+G S ++C
Sbjct: 862  SVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRC 920

Query: 493  LA----TGNWNSVPPECQAI-------------------------------PCTPLLSPQ 517
             +     G W+S  P C  +                                C P    +
Sbjct: 921  TSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGR 980

Query: 518  NGTMTCVQPLGSSSYKSTCQ----------------------------FICDEGYSLSGP 549
              ++TC+  L  SS K  C+                            + C  G+ L G 
Sbjct: 981  PFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGH 1040

Query: 550  ERLDCTRSG---RWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNG- 605
               +C  SG    W+  PP+C+ I C        G    S  R  F+ GS   + C+ G 
Sbjct: 1041 SSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDF-ISTNRENFHYGSVVTYRCNLGS 1099

Query: 606  -----FKLEGPNNVECTTS----GRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCR 656
                 F+L G  ++ CT++    G WS   P C        P V+   L +  +      
Sbjct: 1100 RGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNR------ 1153

Query: 657  HHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSE----LHVNKP 712
                 F  N    F C  GF + G   + C+   +W    P+C  V C      LH    
Sbjct: 1154 ---SLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPEILH---- 1205

Query: 713  IAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
               +  +   NFS G    + C  G  L G+A   C   G WS   P C
Sbjct: 1206 -GEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRC 1253



 Score =  176 bits (446), Expect = 8e-44
 Identities = 157/596 (26%), Positives = 242/596 (40%), Gaps = 75/596 (12%)

Query: 215  HPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASG---IWTNKPPQCLAAQCPPLKIPERG 271
            H + +    S+ ++ CT G+++ G S  EC+ SG    W+ KPP C    C        G
Sbjct: 1016 HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANG 1075

Query: 272  NMTCLHSAKAFQHQSSCSFSCEEG------FALVGPEVVQCTAS----GVWTAPAPVCKA 321
            +     + + F + S  ++ C  G      F LVG   + CT++    G+W+ PAP C  
Sbjct: 1076 DFIST-NRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC-I 1133

Query: 322  VQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC 381
            +  +      E  +      + F+     +F CQPG+ ++G   ++C     W   LP+C
Sbjct: 1134 IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 1193

Query: 382  EAISCEPLESPVHGSMDCSPSLR-AFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPA 440
              + C+P    +HG  + +PS +  F       + C  G+ LRGA  + C   G W+  A
Sbjct: 1194 SRV-CQPPPEILHG--EHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEA 1250

Query: 441  PVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGN--- 497
            P C    C D  +          P    +  +  SF C+EG  L G+SV  C+  G    
Sbjct: 1251 PRCAVKSCDDF-LGQLPHGRVLFPLN-LQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSL 1308

Query: 498  WNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDE------GYSLSGPER 551
            WN+  P C+ I C    +  NG  T   P G   Y     + CD        ++L G   
Sbjct: 1309 WNNSVPVCEHIFCPNPPAILNGRHTGT-PSGDIPYGKEISYTCDPHPDRGMTFNLIGEST 1367

Query: 552  LDCTR----SGRWTDSPPMCEA------IKCPELFAPEQGSLDCSDTRGEFNVGSTCHFS 601
            + CT     +G W+   P CE        K PE F     ++  +D   EF VG++ ++ 
Sbjct: 1368 IRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDF--EFPVGTSLNYE 1425

Query: 602  CDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGT 661
            C  G+      ++ C  +  WS+    C+  +  P P         P  G +   H    
Sbjct: 1426 CRPGY-FGKMFSISCLENLVWSSVEDNCRRKSCGPPP--------EPFNGMV---HINTD 1473

Query: 662  FGFNTTCYFGCNAGFTLIGDSTLSCRPSGQ---WTAVTPACRAVKCSELHVNKPIAMN-- 716
              F +T  + CN GF LIG  + +C  SG    W    P C  + C       P   N  
Sbjct: 1474 TQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEP----PPTISNGD 1529

Query: 717  -CSNLWGNFSYGSICSFHCLEG----QL--LNGSAQTAC----QENGHWSTTVPTC 761
              SN   +F  G++ ++ C  G    QL  L G     C     + G WS+  P C
Sbjct: 1530 FYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRC 1585



 Score =  175 bits (443), Expect = 2e-43
 Identities = 171/677 (25%), Positives = 269/677 (39%), Gaps = 116/677 (17%)

Query: 184  SCYPGF--YGPECEYVRECGEL--ELPQHVLMNCSHPLG-----------NFSFNSQCSF 228
            SC PG+   G    +    G+   E P+  + +C   LG           N    ++ SF
Sbjct: 1225 SCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSF 1284

Query: 229  HCTDGYQVNGPSKLECLASG---IWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQ 285
             C +G+++ G S   C+  G   +W N  P C    CP       G  T   S     + 
Sbjct: 1285 VCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGD-IPYG 1343

Query: 286  SSCSFSCEEG------FALVGPEVVQCTA----SGVWTAPAPVCK-AVQCQHLEAPSEGT 334
               S++C+        F L+G   ++CT+    +GVW++PAP C+ +V+  H + P +  
Sbjct: 1344 KEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFP 1403

Query: 335  MDC-VHPLTAFAY--GSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLES 391
                  P+  F +  G+S  +EC+PGY  + +  + C+++  WS+    C   SC P   
Sbjct: 1404 FASPTIPINDFEFPVGTSLNYECRPGYFGK-MFSISCLENLVWSSVEDNCRRKSCGPPPE 1462

Query: 392  PVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRC---DNLGQWTAPAPVCQALQC 448
            P +G +  +      Q+ +  ++ C EGF L G+    C    N   W   AP+C+ + C
Sbjct: 1463 PFNGMVHINTDT---QFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISC 1519

Query: 449  QDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEG------LLLVGASVLQCLA----TGNW 498
            +  P  +      S+   +F   +V ++ C+ G        LVG   + C +     G W
Sbjct: 1520 EPPPTISNGDFY-SNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVW 1578

Query: 499  NSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFI---CDEGYSLSGPERLDCT 555
            +S PP C  I      +P+      ++  G+ S+ +  + I   C  G+ + G   + C 
Sbjct: 1579 SSPPPRC--ISTNKCTAPE--VENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQ 1634

Query: 556  RSGRWTDSPPMCEAIKC---PELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPN 612
             +GRW    P C  + C   PE+   E  +L   D    F+ G    +SC+  + L G  
Sbjct: 1635 TNGRWGPKLPHCSRV-CQPPPEILHGEH-TLSHQDN---FSPGQEVFYSCEPSYDLRGAA 1689

Query: 613  NVECTTSGRWSATPPTCKG------IASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNT 666
            ++ CT  G WS   P C        +  LP   V  P     G                 
Sbjct: 1690 SLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVS------------- 1736

Query: 667  TCYFGCNAGFTLIGDSTLSCRPSGQ---WTAVTPACRAVKCSELHVNKPIAMNCSNL--- 720
               F C+ GF L G S   C  +G    W +  P C  + C     N P  +N  +    
Sbjct: 1737 ---FVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCP----NPPAILNGRHTGTP 1789

Query: 721  WGNFSYGS----ICSFHCLEGQLLN--GSAQTAC----QENGHWSTTVPTCQAG------ 764
            +G+  YG      C  H   G   N  G +   C    Q NG WS+  P C+        
Sbjct: 1790 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACP 1849

Query: 765  -PLTIQEALTYFGGAVA 780
             P  IQ    Y GG V+
Sbjct: 1850 HPPKIQNG-HYIGGHVS 1865



 Score =  169 bits (429), Expect = 7e-42
 Identities = 156/601 (25%), Positives = 234/601 (38%), Gaps = 88/601 (14%)

Query: 215 HPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASG---IWTNKPPQCLAAQCPPLKIPERG 271
           H +    F SQ  + CT GY++ G S   C+ SG   IW N+ P C    C        G
Sbjct: 116 HVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNG 175

Query: 272 NMTCLHSAKAFQHQSSCSFSCEEG------FALVGPEVVQCTAS----GVWTAPAPVCKA 321
           +     + + F + S  ++ C  G      F LVG   + CT++    G+W+ PAP C  
Sbjct: 176 DFIST-NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC-I 233

Query: 322 VQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC 381
           +  +      E  +      + F+     +F CQPG+ ++G   ++C     W   LP+C
Sbjct: 234 IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 293

Query: 382 EAISCEPLESPVHGSM------DCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ 435
             + C+P    +H         + SP    F       + C  G+ LRGA  +RC   G 
Sbjct: 294 SRV-CQPPPDVLHAERTQRDKDNFSPGQEVF-------YSCEPGYDLRGAASMRCTPQGD 345

Query: 436 WTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLAT 495
           W+  AP C+   C D  +          P    +  +   F C+EG  L G+S   C+  
Sbjct: 346 WSPAAPTCEVKSCDDF-MGQLLNGRVLFPVN-LQLGAKVDFVCDEGFQLKGSSASYCVLA 403

Query: 496 GN---WNSVPPECQAIPC-TPLLSPQNGTMTCVQPLGSSSYKSTCQFICD------EGYS 545
           G    WNS  P C+ I C +P + P NG  T  +PL    +  T  + CD        + 
Sbjct: 404 GMESLWNSSVPVCEQIFCPSPPVIP-NGRHT-GKPLEVFPFGKTVNYTCDPHPDRGTSFD 461

Query: 546 LSGPERLDCTR----SGRWTDSPPMCEAI---KCPE--LFAPEQGSLDCSDTRGEFNVGS 596
           L G   + CT     +G W+   P C  +   + P+  LFA  +   + SD    F +G+
Sbjct: 462 LIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD----FPIGT 517

Query: 597 TCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCR 656
           +  + C   +    P ++ C  +  WS+    CK           C     P  G +   
Sbjct: 518 SLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCK--------RKSCKTPPDPVNGMV--- 565

Query: 657 HHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSG---QWTAVTPACRAVKCSELHVNKPI 713
           H        +   + C  G  LIG S+  C  SG    W+   P C+ + C       P 
Sbjct: 566 HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCG----LPPT 621

Query: 714 AMN---CSNLWGNFSYGSICSFHCLEGQ------LLNGSAQTACQEN----GHWSTTVPT 760
             N    S    NF YGS+ ++ C  G        L G     C  N    G WS   P 
Sbjct: 622 IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 681

Query: 761 C 761
           C
Sbjct: 682 C 682



 Score =  165 bits (417), Expect = 2e-40
 Identities = 143/578 (24%), Positives = 219/578 (37%), Gaps = 57/578 (9%)

Query: 220 FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSA 279
           F   +  ++ C  GY    P  + CL + +WT    +C    C     P  G    +H  
Sbjct: 63  FPIGTYLNYECRPGYS-GRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNG---MVHVI 118

Query: 280 KAFQHQSSCSFSCEEGFALVGPEVVQCTASG---VWTAPAPVCKAVQCQHLEAPSEGTMD 336
           K  Q  S   +SC +G+ L+G     C  SG   +W    P+C  + C      + G   
Sbjct: 119 KGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFI 178

Query: 337 CVHPLTAFAYGSSCKFECQPG------YRVRGLDMLRCIDS----GHWSAPLPTCEAIS- 385
             +    F YGS   + C PG      + + G   + C  +    G WS P P C   + 
Sbjct: 179 STN-RENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 237

Query: 386 CEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQA 445
           C P    V   +  S +   F  +    FRC  GF+++G   V+C  L +W    P C  
Sbjct: 238 CTP--PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR 295

Query: 446 LQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPEC 505
           + CQ  P    A          F       ++C  G  L GA+ ++C   G+W+   P C
Sbjct: 296 V-CQPPPDVLHAE-RTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 353

Query: 506 QAIPCTPLLSP-QNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR---WT 561
           +   C   +    NG +     L      +   F+CDEG+ L G     C  +G    W 
Sbjct: 354 EVKSCDDFMGQLLNGRVLFPVNL---QLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWN 410

Query: 562 DSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCD------NGFKLEGPNNVE 615
            S P+CE I CP       G          F  G T +++CD        F L G + + 
Sbjct: 411 SSVPVCEQIFCPSPPVIPNGR-HTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIR 469

Query: 616 CTT----SGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFG 671
           CT+    +G WS+  P C GI         C A        +  + +   F   T+  + 
Sbjct: 470 CTSDPQGNGVWSSPAPRC-GILG------HCQAPDHFLFAKLKTQTNASDFPIGTSLKYE 522

Query: 672 CNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMN-CSNLWGNFSYGSIC 730
           C   +      +++C  +  W++    C+   C       P  +N   ++  +   GS  
Sbjct: 523 CRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSCK----TPPDPVNGMVHVITDIQVGSRI 577

Query: 731 SFHCLEGQLLNGSAQTACQENG---HWSTTVPTCQAGP 765
           ++ C  G  L G +   C  +G   HWST  P CQ  P
Sbjct: 578 NYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIP 615



 Score =  156 bits (394), Expect = 9e-38
 Identities = 150/653 (22%), Positives = 235/653 (35%), Gaps = 126/653 (19%)

Query: 216  PLGNFSFNSQCSFHCTD------GYQVNGPSKLECLA----SGIWTNKPPQC-LAAQCPP 264
            PL  F F    ++ C         + + G S + C +    +G+W++  P+C +   C  
Sbjct: 436  PLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQA 495

Query: 265  LKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQC 324
                    +    +A  F   +S  + C   +    P  + C  + VW++P  VCK   C
Sbjct: 496  PDHFLFAKLKTQTNASDFPIGTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRKSC 554

Query: 325  QHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSG---HWSAPLPTC 381
            +    P  G    VH +T    GS   + C  G+R+ G     CI SG   HWS   P C
Sbjct: 555  KTPPDPVNGM---VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPIC 611

Query: 382  EAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEG------FMLRGADIVRC----D 431
            + I C    +  +G    S +   F Y +  ++RC  G      F L G   + C    D
Sbjct: 612  QRIPCGLPPTIANGDF-ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 670

Query: 432  NLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQ 491
             +G W+ PAP C  +  +  P   E  +  S     F    V  F C  G ++ G   ++
Sbjct: 671  QVGIWSGPAPQC-IIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK 729

Query: 492  CLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPER 551
            C A   W    P C  + C P     +   T  +   + S      + C+ GY L G   
Sbjct: 730  CQALNKWEPELPSCSRV-CQPPPDVLHAERT-QRDKDNFSPGQEVFYSCEPGYDLRGAAS 787

Query: 552  LDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGP 611
            + CT  G W+ + P CE   C +                   +G+   F CD GF+L+G 
Sbjct: 788  MRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGS 845

Query: 612  NNVECTTSGR---WSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPG----TFGF 664
            +   C  +G    W+++ P C+ I         CP+      G      H G     F F
Sbjct: 846  SASYCVLAGMESLWNSSVPVCEQIF--------CPSPPVIPNG-----RHTGKPLEVFPF 892

Query: 665  NTTCYFGCN------AGFTLIGDSTLSC----RPSGQWTAVTPACRAV------------ 702
                 + C+        F LIG+ST+ C    + +G W++  P C  +            
Sbjct: 893  GKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFA 952

Query: 703  -------------------KCSELHVNKPIAMNCSN--LWGN------------------ 723
                               +C   +  +P ++ C +  +W +                  
Sbjct: 953  KLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVN 1012

Query: 724  --------FSYGSICSFHCLEGQLLNGSAQTACQENG---HWSTTVPTCQAGP 765
                       GS  ++ C  G  L G +   C  +G   HWST  P CQ  P
Sbjct: 1013 GMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIP 1065



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 82/337 (24%), Positives = 120/337 (35%), Gaps = 42/337 (12%)

Query: 443 CQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVP 502
           C A +      P         P G +      ++ C  G      S++ CL    W    
Sbjct: 43  CNAPEWLPFARPTNLTDEFEFPIGTY-----LNYECRPGYSGRPFSII-CLKNSVWTGAK 96

Query: 503 PECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR--- 559
             C+   C     P NG +  ++ +    + S  ++ C +GY L G     C  SG    
Sbjct: 97  DRCRRKSCRNPPDPVNGMVHVIKGI---QFGSQIKYSCTKGYRLIGSSSATCIISGDTVI 153

Query: 560 WTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNG------FKLEGPNN 613
           W +  P+C+ I C        G    S  R  F+ GS   + C+ G      F+L G  +
Sbjct: 154 WDNETPICDRIPCGLPPTITNGDF-ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPS 212

Query: 614 VECTTS----GRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCY 669
           + CT++    G WS   P C        P V+   L +  +           F  N    
Sbjct: 213 IYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL---------FSLNEVVE 263

Query: 670 FGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSE----LHVNKPIAMNCSNLWGNFS 725
           F C  GF + G   + C+   +W    P+C  V C      LH  +           NFS
Sbjct: 264 FRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDK-----DNFS 317

Query: 726 YGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762
            G    + C  G  L G+A   C   G WS   PTC+
Sbjct: 318 PGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCE 354


>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
           sapiens]
          Length = 569

 Score =  162 bits (411), Expect = 9e-40
 Identities = 139/513 (27%), Positives = 200/513 (38%), Gaps = 59/513 (11%)

Query: 220 FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSA 279
           F   +  ++ C  GY    P  + CL + +WT+   +C    C     P  G     H  
Sbjct: 55  FPIGTYLNYECRPGYS-GRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNG---MAHVI 110

Query: 280 KAFQHQSSCSFSCEEGFALVGPEVVQCTASG---VWTAPAPVCKAVQCQHLEAPSEGTMD 336
           K  Q +S   +SC +G+ L+G     C  SG   +W    PVC  + C      + G   
Sbjct: 111 KDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFT 170

Query: 337 CVHPLTAFAYGSSCKFECQPGYRVR------GLDMLRCIDS----GHWSAPLPTCEAIS- 385
            +     F YGS   + C  G R +      G   + C       G WS P P C   + 
Sbjct: 171 SI-SREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNK 229

Query: 386 CEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQA 445
           C P    V   +  S +   F  +    FRC  GF ++G   V+C  L +W    P C  
Sbjct: 230 CTP--PNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSR 287

Query: 446 LQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPEC 505
           + CQ  P    A          F       ++C  G  L G++ L C   G+W+   P C
Sbjct: 288 V-CQPPPDVLHAE-RTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC 345

Query: 506 QAIPCTPLLSP-QNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR---WT 561
           +   C   L    NG +  + PL +    +   F+CDEG+ L G     C  +G    W 
Sbjct: 346 EVKSCDDFLGQLPNGHV--LFPL-NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWN 402

Query: 562 DSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSG- 620
            S P+CE   C     P  G +       + +VGS  ++SC  G +L G ++ EC  SG 
Sbjct: 403 SSVPVCERKSCETPPVPVNGMVHVIT---DIHVGSRINYSCTTGHRLIGHSSAECILSGN 459

Query: 621 --RWSATPPTCKGIASLPTPGVQCPALT-TP------GQGTMY-CRHHPGTFGFNTTCYF 670
              WS  PP C+ I     P +     T TP      G+   Y C  HP           
Sbjct: 460 TAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDR--------- 510

Query: 671 GCNAGFTLIGDSTL--SCRP--SGQWTAVTPAC 699
                F LIG+ST+  +  P  +G W++  P C
Sbjct: 511 --GMTFNLIGESTIRRTSEPHGNGVWSSPAPRC 541



 Score =  158 bits (400), Expect = 2e-38
 Identities = 123/464 (26%), Positives = 187/464 (40%), Gaps = 59/464 (12%)

Query: 206 PQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASG---IWTNKPPQCLAAQC 262
           P   +   +H + +  F SQ  + C  GY++ G S   C+ SG   IW NK P C    C
Sbjct: 99  PPDPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIIC 158

Query: 263 PPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEG------FALVGPEVVQCTAS----GVW 312
                   G+ T + S + F + S  ++ C  G      F LVG   + CT+     G+W
Sbjct: 159 GLPPTIANGDFTSI-SREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIW 217

Query: 313 TAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSG 372
           + PAP C  +  +      E  +      + F+     +F CQPG+ ++G   ++C    
Sbjct: 218 SGPAPQC-IIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALN 276

Query: 373 HWSAPLPTCEAISCEPLESPVHGSM------DCSPSLRAFQYDTNCSFRCAEGFMLRGAD 426
            W   LP+C  + C+P    +H         + SP    F       + C  G+ LRG+ 
Sbjct: 277 KWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFSPGQEVF-------YSCEPGYDLRGST 328

Query: 427 IVRCDNLGQWTAPAPVCQALQCQDL--PVPNEARVNCSHPFGAFRYQ--SVCSFTCNEGL 482
            + C   G W+  AP C+   C D    +PN       H       Q  +   F C+EG 
Sbjct: 329 YLHCTPQGDWSPAAPRCEVKSCDDFLGQLPN------GHVLFPLNLQLGAKVDFVCDEGF 382

Query: 483 LLVGASVLQCLATGN---WNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFI 539
            L G+S   C+  G    WNS  P C+   C     P NG +  +  +      S   + 
Sbjct: 383 QLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDI---HVGSRINYS 439

Query: 540 CDEGYSLSGPERLDCTRSG---RWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGS 596
           C  G+ L G    +C  SG    W+  PP+C+ I CP   A   G        G+   G 
Sbjct: 440 CTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGR-HTGTPLGDIPYGK 498

Query: 597 TCHFSCD------NGFKLEGPNNVECTT----SGRWSATPPTCK 630
              ++CD        F L G + +  T+    +G WS+  P C+
Sbjct: 499 EVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542



 Score =  149 bits (375), Expect = 1e-35
 Identities = 130/508 (25%), Positives = 194/508 (38%), Gaps = 61/508 (12%)

Query: 289 SFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGS 348
           ++ C  G++   P  + C  + VWT+    CK   C++   P  G     H +    + S
Sbjct: 62  NYECRPGYS-GRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNG---MAHVIKDIQFRS 117

Query: 349 SCKFECQPGYRVRGLDMLRCIDSGH---WSAPLPTCEAISCEPLESPVHGSMDCSPSLRA 405
             K+ C  GYR+ G     CI SG+   W    P C+ I C    +  +G    S S   
Sbjct: 118 QIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDF-TSISREY 176

Query: 406 FQYDTNCSFRCAEG------FMLRGADIVRC----DNLGQWTAPAPVCQALQCQDLPVPN 455
           F Y +  ++ C  G      F L G   + C    D +G W+ PAP C  +  +  P   
Sbjct: 177 FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQC-IIPNKCTPPNV 235

Query: 456 EARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLS 515
           E  +  S     F    V  F C  G  + G S ++C A   W    P C  + C P   
Sbjct: 236 ENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV-CQPPPD 294

Query: 516 PQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPEL 575
             +   T  +   + S      + C+ GY L G   L CT  G W+ + P CE   C + 
Sbjct: 295 VLHAERT-QRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDF 353

Query: 576 FAPEQGSLDCSDTRGEFN--VGSTCHFSCDNGFKLEGPNNVECTTSGR---WSATPPTCK 630
                G L         N  +G+   F CD GF+L+G +   C  +G    W+++ P C+
Sbjct: 354 L----GQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCE 409

Query: 631 GIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSG 690
                     + P +   G   +    H G     +   + C  G  LIG S+  C  SG
Sbjct: 410 ------RKSCETPPVPVNGMVHVITDIHVG-----SRINYSCTTGHRLIGHSSAECILSG 458

Query: 691 ---QWTAVTPACRAVKCSELHVNKPIAMN---CSNLWGNFSYGSICSFHC-------LEG 737
               W+   P C+ + C     N P  +N        G+  YG   S+ C       +  
Sbjct: 459 NTAHWSMKPPICQQIFCP----NPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTF 514

Query: 738 QLLNGSAQTACQE---NGHWSTTVPTCQ 762
            L+  S      E   NG WS+  P C+
Sbjct: 515 NLIGESTIRRTSEPHGNGVWSSPAPRCE 542



 Score =  125 bits (313), Expect = 2e-28
 Identities = 98/383 (25%), Positives = 151/383 (39%), Gaps = 54/383 (14%)

Query: 406 FQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPF 465
           F   T  ++ C  G+  R   I+ C     WT+    C+   C++ P P       +H  
Sbjct: 55  FPIGTYLNYECRPGYSGRPFSII-CLKNSVWTSAKDKCKRKSCRNPPDPVNGM---AHVI 110

Query: 466 GAFRYQSVCSFTCNEGLLLVGASVLQCLATGN---WNSVPPECQAIPCTPLLSPQNGTMT 522
              +++S   ++C +G  L+G+S   C+ +GN   W++  P C  I C    +  NG  T
Sbjct: 111 KDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFT 170

Query: 523 CVQPLGSSSYKSTCQFICDEG------YSLSGPERLDCTRS----GRWTDSPPMCEAIKC 572
            +       Y S   + C+ G      + L G   + CT      G W+   P C     
Sbjct: 171 SISR-EYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCII--- 226

Query: 573 PELFAP---EQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTC 629
           P    P   E G L  SD R  F++     F C  GF ++GP++V+C    +W    P+C
Sbjct: 227 PNKCTPPNVENGIL-VSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSC 285

Query: 630 KGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPS 689
             +   P P V     T         +     F      ++ C  G+ L G + L C P 
Sbjct: 286 SRVCQ-PPPDVLHAERT---------QRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQ 335

Query: 690 GQWTAVTPACRAVKCSEL-------HVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNG 742
           G W+   P C    C +        HV  P+         N   G+   F C EG  L G
Sbjct: 336 GDWSPAAPRCEVKSCDDFLGQLPNGHVLFPL---------NLQLGAKVDFVCDEGFQLKG 386

Query: 743 SAQTACQENGH---WSTTVPTCQ 762
           S+ + C   G    W+++VP C+
Sbjct: 387 SSASYCVLAGMESLWNSSVPVCE 409



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 41/144 (28%), Positives = 66/144 (45%), Gaps = 22/144 (15%)

Query: 192 PECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASG--- 248
           P CE  + C   E P   +    H + +    S+ ++ CT G+++ G S  EC+ SG   
Sbjct: 406 PVCER-KSC---ETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTA 461

Query: 249 IWTNKPPQCLAAQC--PPLKIPERGNMTCLHSAKAFQHQSSCSFSCEE------GFALVG 300
            W+ KPP C    C  PP  +  R   T L       +    S++C+        F L+G
Sbjct: 462 HWSMKPPICQQIFCPNPPAILNGRHTGTPLGD---IPYGKEVSYTCDPHPDRGMTFNLIG 518

Query: 301 PEVVQCTA----SGVWTAPAPVCK 320
              ++ T+    +GVW++PAP C+
Sbjct: 519 ESTIRRTSEPHGNGVWSSPAPRCE 542


>gi|4502503 complement component 4 binding protein, alpha chain
           precursor [Homo sapiens]
          Length = 597

 Score =  137 bits (345), Expect = 4e-32
 Identities = 124/490 (25%), Positives = 198/490 (40%), Gaps = 61/490 (12%)

Query: 162 SCQDMSCSKQGECLETIGNYTCSCYPGFYGPECEY--VRECGELELPQHVLMNCSHPLGN 219
           S Q ++C+  GE +              Y   C Y   R  GEL   Q  +        +
Sbjct: 90  STQTLTCNSDGEWV--------------YNTFCIYKRCRHPGELRNGQVEIKT------D 129

Query: 220 FSFNSQCSFHCTDGYQVNGPSKLECLAS--GI-WTNKPPQCLAAQCPPLKIPERGNMTCL 276
            SF SQ  F C++G+ + G +   C     G+ W++  PQC   +C P      G     
Sbjct: 130 LSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGR---- 185

Query: 277 HSAKA--FQHQSSCSFSCEEGFALVGPEVVQCTAS----GVWTAPAPVCKAVQCQHLEAP 330
           HS +   + +  S ++SC+  F+L+G   + CT      GVW    P C+ + C+  +  
Sbjct: 186 HSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVS 245

Query: 331 SEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLE 390
               +    P+  + Y  +  F+CQ G+ +RG  ++ C     W+   P CE  SC  L 
Sbjct: 246 HGEMVSGFGPI--YNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLP 303

Query: 391 SPVHGSMDCSPSLR---AFQYDTNCSFRCAEGFMLRGAD--IVRCDNLGQWTAPAPVCQA 445
              H S +  P       +   T   +RC  G+     +   V C    +WT P   C+A
Sbjct: 304 DIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWT-PYQGCEA 362

Query: 446 LQCQDLPVPN----EARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSV 501
           L C +  + N    + R +       + Y    SF+C+E           C   G W+  
Sbjct: 363 LCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAI----CQGDGTWSPR 418

Query: 502 PPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWT 561
            P C  I   P   P+       Q    S +K    + CD+GY L G  +L C+ S  W+
Sbjct: 419 TPSCGDICNFP---PKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYS-HWS 474

Query: 562 DSPPMCEAI-KCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSG 620
              P C+A+ + PEL     G L  S  + ++         CD+G+ + GP ++ C+ + 
Sbjct: 475 APAPQCKALCRKPELV---NGRL--SVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNR 529

Query: 621 RWSATPPTCK 630
            W    P C+
Sbjct: 530 TWYPEVPKCE 539



 Score =  129 bits (324), Expect = 1e-29
 Identities = 112/453 (24%), Positives = 176/453 (38%), Gaps = 56/453 (12%)

Query: 335 MDCVHPLTAFAYGSSCKFECQPGY-RVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPV 393
           MD     T F  G++ K+ C PGY R      L C   G W      C    C       
Sbjct: 62  MDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEW-VYNTFCIYKRCRHPGELR 120

Query: 394 HGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRC---DNLGQWTAPAPVCQALQCQD 450
           +G ++    L    + +   F C+EGF L G+   RC   D    W+ P P C+ ++C+ 
Sbjct: 121 NGQVEIKTDL---SFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKP 177

Query: 451 LPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCL----ATGNWNSVPPECQ 506
            P     R +    F A+ +    +++C+    L+G + + C       G W   PP C+
Sbjct: 178 PPDIRNGRHSGEENFYAYGFS--VTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCE 235

Query: 507 AIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPM 566
            I C          ++   P+   +YK T  F C +G+ L G   + C    +W  SPP 
Sbjct: 236 KITCRKPDVSHGEMVSGFGPI--YNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPA 293

Query: 567 CEAIKC---PELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFK--LEGPNNVECTTSGR 621
           CE   C   P++      +         + VG+   + C  G+K   + P  V C  + R
Sbjct: 294 CEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLR 353

Query: 622 WSATPPTCKGIASLPTPGVQCPALTTP------GQGTMYCRHHPGTFGFNTTCYFGCNAG 675
           W              TP   C AL  P      G+ T + +  P     +   ++G    
Sbjct: 354 W--------------TPYQGCEALCCPEPKLNNGEITQHRKSRPAN---HCVYFYGDEIS 396

Query: 676 FTLIGDSTLS--CRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSI---C 730
           F+    S  S  C+  G W+  TP+C  +       N P  +   +   + SY       
Sbjct: 397 FSCHETSRFSAICQGDGTWSPRTPSCGDI------CNFPPKIAHGHYKQSSSYSFFKEEI 450

Query: 731 SFHCLEGQLLNGSAQTACQENGHWSTTVPTCQA 763
            + C +G +L G A+ +C  + HWS   P C+A
Sbjct: 451 IYECDKGYILVGQAKLSCSYS-HWSAPAPQCKA 482



 Score =  119 bits (299), Expect = 9e-27
 Identities = 123/497 (24%), Positives = 186/497 (37%), Gaps = 46/497 (9%)

Query: 220 FSFNSQCSFHCTDGY-QVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHS 278
           F   +   + C  GY + +    L C + G W      C+  +C   + P       +  
Sbjct: 71  FKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRC---RHPGELRNGQVEI 126

Query: 279 AKAFQHQSSCSFSCEEGFALVGPEVVQCTAS--GV-WTAPAPVCKAVQCQHLEAPSEGTM 335
                  S   FSC EGF L+G    +C     GV W+ P P C+ V+C+       G  
Sbjct: 127 KTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRH 186

Query: 336 DCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDS----GHWSAPLPTCEAISCEPLES 391
                   +AYG S  + C P + + G   + C       G W    PTCE I+C   + 
Sbjct: 187 SGEENF--YAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDV 244

Query: 392 PVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDL 451
             HG M  S     + Y     F+C +GF+LRG+ ++ CD   +W    P C+   C +L
Sbjct: 245 S-HGEM-VSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINL 302

Query: 452 P-VPNEARVNCSHPF--GAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPE-CQA 507
           P +P+ +      P     +   +V  + C+ G           +   N    P + C+A
Sbjct: 303 PDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQGCEA 362

Query: 508 IPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDE-GYSLSGPERLD--CTRSGRWTDSP 564
           + C P     NG +T  Q   S        F  DE  +S     R    C   G W+   
Sbjct: 363 L-CCPEPKLNNGEIT--QHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPRT 419

Query: 565 PMCEAIKCPELFAPE--QGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRW 622
           P C  I C   F P+   G    S +   F       + CD G+ L G   + C+ S  W
Sbjct: 420 PSCGDI-CN--FPPKIAHGHYKQSSSYSFFK--EEIIYECDKGYILVGQAKLSCSYS-HW 473

Query: 623 SATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDS 682
           SA  P CK +   P              G +           N T    C++G+ ++G  
Sbjct: 474 SAPAPQCKALCRKP----------ELVNGRLSVDKDQYVEPENVT--IQCDSGYGVVGPQ 521

Query: 683 TLSCRPSGQWTAVTPAC 699
           +++C  +  W    P C
Sbjct: 522 SITCSGNRTWYPEVPKC 538



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 48/185 (25%), Positives = 79/185 (42%), Gaps = 14/185 (7%)

Query: 220 FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSA 279
           + +  + SF C +  + +      C   G W+ + P C      P KI   G+     S 
Sbjct: 389 YFYGDEISFSCHETSRFSAI----CQGDGTWSPRTPSCGDICNFPPKIAH-GHYKQSSSY 443

Query: 280 KAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVH 339
             F+ +    + C++G+ LVG   + C+ S  W+APAP CKA+ C+  E  + G +    
Sbjct: 444 SFFKEE--IIYECDKGYILVGQAKLSCSYSH-WSAPAPQCKAL-CRKPELVN-GRLSV-- 496

Query: 340 PLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGS--M 397
               +    +   +C  GY V G   + C  +  W   +P CE  + E  E  + G   M
Sbjct: 497 DKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGKRLM 556

Query: 398 DCSPS 402
            C P+
Sbjct: 557 QCLPN 561


>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
          Length = 1231

 Score =  128 bits (321), Expect = 2e-29
 Identities = 138/616 (22%), Positives = 247/616 (40%), Gaps = 86/616 (13%)

Query: 184  SCYPGF--YGP---ECEYVRECGELELPQHVLMNCSHPL----GN--------FSFNSQC 226
            SC PGF   GP   +C +     +L + +  + +C  P     GN        +  +   
Sbjct: 596  SCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVV 655

Query: 227  SFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQS 286
             ++C   + + GP+K++C+  G WT  P  C+  +     IPE  +     S+  + +  
Sbjct: 656  EYYCNPRFLMKGPNKIQCV-DGEWTTLPV-CIVEESTCGDIPELEHGWAQLSSPPYYYGD 713

Query: 287  SCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAV----QC---------QHLEAPSEG 333
            S  F+C E F ++G   + C   GVWT   P C A+    +C         +HL+   E 
Sbjct: 714  SVEFNCSESFTMIGHRSITC-IHGVWT-QLPQCVAIDKLKKCKSSNLIILEEHLKNKKE- 770

Query: 334  TMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCE--PLES 391
                      F + S+ ++ C+      G     CI +G W  P   C     +  P   
Sbjct: 771  ----------FDHNSNIRYRCR---GKEGWIHTVCI-NGRWD-PEVNCSMAQIQLCPPPP 815

Query: 392  PVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC-QALQCQD 450
             +  S + + +L  ++     S  C E ++++  + + C + G+W +  P+C + + C  
Sbjct: 816  QIPNSHNMTTTLN-YRDGEKVSVLCQENYLIQEGEEITCKD-GRWQS-IPLCVEKIPCSQ 872

Query: 451  LPVPNEARVNCSHPF-GAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIP 509
             P      +N S     ++ + +  S+TC  G  +   +   C   G W+S PP+C+ +P
Sbjct: 873  PPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCY-MGKWSS-PPQCEGLP 930

Query: 510  CTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEA 569
            C       +G +  +    S  Y     + C EG+ + GP    C   G     PP C  
Sbjct: 931  CKSPPEISHGVVAHMS--DSYQYGEEVTYKCFEGFGIDGPAIAKCL--GEKWSHPPSCIK 986

Query: 570  IKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTC 629
              C  L + E  ++   + +  +  G    ++C   +K++G +NV C  S RW+   PTC
Sbjct: 987  TDCLSLPSFE-NAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINS-RWTGR-PTC 1043

Query: 630  KGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPS 689
            +  + +  P VQ   + +              +       + C + + + GD  + C  +
Sbjct: 1044 RDTSCVNPPTVQNAYIVS---------RQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-N 1093

Query: 690  GQWTAVTPACRAVKCSELHVNKPIAMNCSNL----WGNFSYGSICSFHCLEGQLLNGSAQ 745
            G WT   P C   K S      P  ++  ++       ++  S   + C     L G+ +
Sbjct: 1094 GNWTE-PPQC---KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKR 1149

Query: 746  TACQENGHWSTTVPTC 761
              C+ NG WS   P C
Sbjct: 1150 ITCR-NGQWSEP-PKC 1163



 Score =  113 bits (282), Expect = 8e-25
 Identities = 99/417 (23%), Positives = 172/417 (41%), Gaps = 22/417 (5%)

Query: 219  NFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHS 278
            N+    + S  C + Y +    ++ C   G W + P       C      E G +    S
Sbjct: 828  NYRDGEKVSVLCQENYLIQEGEEITC-KDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRS 886

Query: 279  AK-AFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDC 337
            ++ ++ H +  S++CE GF +       C   G W++P P C+ + C+     S G +  
Sbjct: 887  SQESYAHGTKLSYTCEGGFRISEENETTCYM-GKWSSP-PQCEGLPCKSPPEISHGVV-- 942

Query: 338  VHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSM 397
             H   ++ YG    ++C  G+ + G  + +C+    WS P P+C    C  L S    ++
Sbjct: 943  AHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWSHP-PSCIKTDCLSLPS-FENAI 999

Query: 398  DCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEA 457
                    ++     ++ CA  + + GA  V C N  +WT   P C+   C + P    A
Sbjct: 1000 PMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCIN-SRWTG-RPTCRDTSCVNPPTVQNA 1057

Query: 458  RVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIP--CTPLLS 515
             +  S     +       + C     + G   + CL  GNW   PP+C+     C P   
Sbjct: 1058 YI-VSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NGNWTE-PPQCKDSTGKCGPPPP 1114

Query: 516  PQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMC--EAIKCP 573
              NG +T   PL   +  S+ ++ C   Y L G +R+ C R+G+W++ PP C    +   
Sbjct: 1115 IDNGDITSF-PLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSE-PPKCLHPCVISR 1171

Query: 574  ELFAPEQGSLDCSDTRGEFN-VGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTC 629
            E+      +L  +  +  ++  G +  F C  G++L   ++   TT        PTC
Sbjct: 1172 EIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTC 1228



 Score =  109 bits (272), Expect = 1e-23
 Identities = 138/571 (24%), Positives = 220/571 (38%), Gaps = 85/571 (14%)

Query: 224 SQCSFHCTDGYQVNGPSKLECLASGIWTNKPP--QCLAAQCPPLKIPERGNMTCLHSAKA 281
           +Q  + C  GY+  G   + C   G W    P  +C    C        G  T L     
Sbjct: 46  TQAIYKCRPGYRSLGNVIMVC-RKGEWVALNPLRKCQKRPCGHPGDTPFGTFT-LTGGNV 103

Query: 282 FQHQSSCSFSCEEGFALVGP-EVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTM--DCV 338
           F++     ++C EG+ L+G     +C   G WT   P+C+ V+C  + AP  G +    +
Sbjct: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAM 162

Query: 339 HPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLE----SPVH 394
            P   + +G + +F C  GY++ G + + C D G WS   P C  ISC+  +    SP+ 
Sbjct: 163 EPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS 222

Query: 395 GSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVP 454
             +    + R FQY  N  +  +E    RG  +  C   G W  P P C+   C +  +P
Sbjct: 223 QKIIYKENER-FQYKCNMGYEYSE----RGDAV--CTESG-W-RPLPSCEEKSCDNPYIP 273

Query: 455 N--EARVNCSHPFGAFRYQSVCSFTCNEGLL-LVGASVLQCLATGNWNSVP-PECQAIPC 510
           N   + +   H  G        ++ C  G       +  +C +TG W  +P P C   PC
Sbjct: 274 NGDYSPLRIKHRTG-----DEITYQCRNGFYPATRGNTAKCTSTG-W--IPAPRCTLKPC 325

Query: 511 TPLLSPQNGTM--TCVQPLGSSSYKSTCQFICDEGY---SLSGPERLDCTRSGRWTDSPP 565
                   G       +P    +      + CDE +   S S  + + CT+ G W+ + P
Sbjct: 326 DYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP 384

Query: 566 MCEAIKCPELFAPEQGSLDCSDTRG-EFNVGSTCHFSCDNGFKL-EGPNNVECTTSGRWS 623
                  P L   E G    +   G +F  G +   +C  G+ L +    V C  +G WS
Sbjct: 385 CLRKCYFPYL---ENG---YNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WS 437

Query: 624 ATPPTCKGIASLPTPGVQCPALTTPGQGTM-----YCRHHPGTFGFNTTCYFGCNAGFTL 678
            TP              +C  + T  + ++     +      T+       + C  G+  
Sbjct: 438 PTP--------------RCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVT 483

Query: 679 IGDST---LSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNC--SNLWGNFSYGSICSFH 733
               T   ++C   G W+A  P C  +K  ++    P+ MN    N +  F       + 
Sbjct: 484 ADGETSGSITCGKDG-WSA-QPTC--IKSCDI----PVFMNARTKNDFTWFKLNDTLDYE 535

Query: 734 CLEGQLLNGSAQT---ACQENGHWSTTVPTC 761
           C +G   N  + T    C  NG WS  +P C
Sbjct: 536 CHDGYESNTGSTTGSIVCGYNG-WS-DLPIC 564



 Score =  104 bits (259), Expect = 4e-22
 Identities = 122/472 (25%), Positives = 177/472 (37%), Gaps = 50/472 (10%)

Query: 318 VCKAVQCQHLEAPSEGTMDCVHPLTAFAY--GSSCKFECQPGYRVRGLDMLRCIDSGHWS 375
           +C A  C  L  P   T       +   Y  G+   ++C+PGYR  G  ++ C   G W 
Sbjct: 15  ICVAEDCNELP-PRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWV 72

Query: 376 A--PLPTCEAISC-EPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVR-CD 431
           A  PL  C+   C  P ++P  G+   +     F+Y     + C EG+ L G    R CD
Sbjct: 73  ALNPLRKCQKRPCGHPGDTP-FGTFTLTGG-NVFEYGVKAVYTCNEGYQLLGEINYRECD 130

Query: 432 NLGQWTAPAPVCQALQCQDLPVPNEARV--NCSHPFGAFRYQSVCSFTCNEGLLLVGASV 489
             G WT   P+C+ ++C  +  P   ++  +   P   + +     F CN G  + G   
Sbjct: 131 TDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEE 189

Query: 490 LQCLATGNWNSVPPECQAIPCTPLLSPQ--NGTMTCVQPLGSSSYKSTCQFICDEGYSLS 547
           + C   G W+   P+C  I C    SP   NG+    + +   + +   Q+ C+ GY  S
Sbjct: 190 MHCSDDGFWSKEKPKCVEISCK---SPDVINGSPISQKIIYKENER--FQYKCNMGYEYS 244

Query: 548 GPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGF- 606
                 CT SG W    P CE   C   + P     D S  R +   G    + C NGF 
Sbjct: 245 ERGDAVCTESG-WRPL-PSCEEKSCDNPYIPNG---DYSPLRIKHRTGDEITYQCRNGFY 299

Query: 607 KLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNT 666
                N  +CT++G W   P     +     P ++   L        Y    P   G   
Sbjct: 300 PATRGNTAKCTSTG-WIPAPRCT--LKPCDYPDIKHGGLYHENMRRPY---FPVAVGKYY 353

Query: 667 TCYFGCNAGFTLIGDS---TLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGN 723
           + Y  C+  F     S    + C   G W+   P  R  KC   ++      N       
Sbjct: 354 SYY--CDEHFETPSGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYNQNHGR---K 405

Query: 724 FSYGSICSFHCLEGQLLNGSAQT-ACQENGHWSTT-----VPTCQAGPLTIQ 769
           F  G      C  G  L  +  T  C ENG WS T     V TC    + I+
Sbjct: 406 FVQGKSIDVACHPGYALPKAQTTVTCMENG-WSPTPRCIRVKTCSKSSIDIE 456



 Score =  101 bits (251), Expect = 3e-21
 Identities = 126/574 (21%), Positives = 211/574 (36%), Gaps = 84/574 (14%)

Query: 220 FSFNSQCSFHCTDGYQVNGP-SKLECLASGIWTNKPPQCLAAQCPPLKIPERGNM--TCL 276
           F +  +  + C +GYQ+ G  +  EC   G WTN  P C   +C P+  PE G +  + +
Sbjct: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAM 162

Query: 277 HSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMD 336
              + +    +  F C  G+ + G E + C+  G W+   P C  + C   ++P      
Sbjct: 163 EPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISC---KSPDVINGS 219

Query: 337 CVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGS 396
            +     +      +++C  GY         C +SG W  PLP+CE  SC   ++P   +
Sbjct: 220 PISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-W-RPLPSCEEKSC---DNPYIPN 274

Query: 397 MDCSPSLRAFQYDTNCSFRCAEGF--MLRGADIVRCDNLGQWTAPAPVCQALQCQ--DLP 452
            D SP     +     +++C  GF    RG +  +C + G W  PAP C    C   D+ 
Sbjct: 275 GDYSPLRIKHRTGDEITYQCRNGFYPATRG-NTAKCTSTG-W-IPAPRCTLKPCDYPDIK 331

Query: 453 VPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASV---LQCLATGNWNSVPPECQAIP 509
                  N   P+         S+ C+E       S    + C   G W+       A+P
Sbjct: 332 HGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WS------PAVP 384

Query: 510 CTPLLSPQNGTMTCVQPLGSSSYK----------STCQFICDEGYSLSGPERLDCTRSGR 559
           C            C  P   + Y            +    C  GY+L   +         
Sbjct: 385 C---------LRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG 435

Query: 560 WTDSPPMCEAIKCPELFAPEQGSLD-----CSDTRGEFNVGSTCHFSCDNGFKL---EGP 611
           W+ +P      +C  +    + S+D      S+++  + +     + C  G+     E  
Sbjct: 436 WSPTP------RCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETS 489

Query: 612 NNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFG 671
            ++ C   G WSA  PTC     +P   V   A T         ++    F  N T  + 
Sbjct: 490 GSITCGKDG-WSA-QPTCIKSCDIP---VFMNART---------KNDFTWFKLNDTLDYE 535

Query: 672 CNAGFTLIGDST---LSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGS 728
           C+ G+     ST   + C  +G W+ + P C   +C    ++  +  +       +  G 
Sbjct: 536 CHDGYESNTGSTTGSIVCGYNG-WSDL-PICYERECELPKIDVHLVPDRKK--DQYKVGE 591

Query: 729 ICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762
           +  F C  G  + G     C   G  S  +P C+
Sbjct: 592 VLKFSCKPGFTIVGPNSVQCYHFG-LSPDLPICK 624



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 104/423 (24%), Positives = 167/423 (39%), Gaps = 43/423 (10%)

Query: 139  PSAPGKWNDEHCLKKKHALCYTASCQDMSCSKQGECLETIGNYTCSCYPGFYGPECEYVR 198
            P  P   N    L  +     +  CQ+    ++GE        TC        P C    
Sbjct: 815  PQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGE------EITCKDGRWQSIPLCVEKI 868

Query: 199  ECGELELPQHVLMNCSHPLG-NFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQC 257
             C +    +H  +N S     +++  ++ S+ C  G++++  ++  C   G W++ PPQC
Sbjct: 869  PCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYM-GKWSS-PPQC 926

Query: 258  LAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAP 317
                C     PE  +    H + ++Q+    ++ C EGF + GP + +C     W+ P P
Sbjct: 927  EGLPCK--SPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWSHP-P 982

Query: 318  VCKAVQCQHLEAPS-EGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSA 376
             C    C  L  PS E  +        +  G    + C   Y++ G   + CI+S  W+ 
Sbjct: 983  SCIKTDC--LSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINS-RWTG 1039

Query: 377  PLPTCEAISCEPLESP-VHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ 435
              PTC   SC  +  P V  +   S  +  +       ++C   + + G + V C N G 
Sbjct: 1040 -RPTCRDTSC--VNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLN-GN 1095

Query: 436  WTAPAPVCQALQCQDL------PVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASV 489
            WT P       QC+D       P P +     S P   +   S   + C     L G   
Sbjct: 1096 WTEPP------QCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKR 1149

Query: 490  LQCLATGNWNSVPPECQAIPCT---PLLSPQNGTM--TCVQPLGSSSYKSTCQFICDEGY 544
            + C   G W S PP+C   PC     ++   N  +  T  Q L S + +S  +F+C  GY
Sbjct: 1150 ITC-RNGQW-SEPPKC-LHPCVISREIMENYNIALRWTAKQKLYSRTGESV-EFVCKRGY 1205

Query: 545  SLS 547
             LS
Sbjct: 1206 RLS 1208



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 120/591 (20%), Positives = 214/591 (36%), Gaps = 66/591 (11%)

Query: 192 PECEYVRECGELELPQH--VLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGI 249
           P CE V+ C  +  P++  ++ +   P   + F     F C  GY++ G  ++ C   G 
Sbjct: 139 PICEVVK-CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGF 197

Query: 250 WTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTAS 309
           W+ + P+C+   C   K P+  N + +     ++      + C  G+         CT S
Sbjct: 198 WSKEKPKCVEISC---KSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTES 254

Query: 310 GVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGY--RVRGLDMLR 367
           G W  P P C+   C +   P+    D          G    ++C+ G+    RG +  +
Sbjct: 255 G-W-RPLPSCEEKSCDNPYIPNG---DYSPLRIKHRTGDEITYQCRNGFYPATRG-NTAK 308

Query: 368 CIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAF---QYDTNCSFRCAEGFMLRG 424
           C  +G W  P P C    C+      HG +      R +         S+ C E F    
Sbjct: 309 CTSTG-W-IPAPRCTLKPCD-YPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPS 365

Query: 425 A---DIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEG 481
               D + C   G W+   P  +      L    E   N +H     + +S+    C+ G
Sbjct: 366 GSYWDHIHCTQDG-WSPAVPCLRKCYFPYL----ENGYNQNHGRKFVQGKSI-DVACHPG 419

Query: 482 LLLVGASVLQCLATGNWNSVPPECQAIPCT-PLLSPQNGTMTCVQPLGSSSYKSTCQFIC 540
             L  A          W+  P   +   C+   +  +NG ++  +   + + K   ++ C
Sbjct: 420 YALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFIS--ESQYTYALKEKAKYQC 477

Query: 541 DEGYSLSGPE---RLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGST 597
             GY  +  E    + C + G W+  P   ++   P +F   +   D +     F +  T
Sbjct: 478 KLGYVTADGETSGSITCGKDG-WSAQPTCIKSCDIP-VFMNARTKNDFT----WFKLNDT 531

Query: 598 CHFSCDNGFKL---EGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMY 654
             + C +G++        ++ C  +G WS  P   +    LP   V         Q    
Sbjct: 532 LDYECHDGYESNTGSTTGSIVCGYNG-WSDLPICYERECELPKIDVHLVPDRKKDQ---- 586

Query: 655 CRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIA 714
                  +       F C  GFT++G +++ C   G    ++P     K        P  
Sbjct: 587 -------YKVGEVLKFSCKPGFTIVGPNSVQCYHFG----LSPDLPICKEQVQSCGPPPE 635

Query: 715 MNCSNL----WGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
           +   N+       + +  +  ++C    L+ G  +  C + G W TT+P C
Sbjct: 636 LLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVD-GEW-TTLPVC 684


>gi|110611237 coagulation factor XIII B subunit precursor [Homo
           sapiens]
          Length = 661

 Score =  118 bits (295), Expect = 3e-26
 Identities = 118/455 (25%), Positives = 179/455 (39%), Gaps = 75/455 (16%)

Query: 212 NCSHPLGNFSFNSQCSFHCTDGYQVNGPSK---LECLASGIWTNKPPQCLAAQCPPLKIP 268
           N S     F    +  + C  GY   G  K   +ECL  G W+   P+C   +C  L++ 
Sbjct: 162 NYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WS-LTPKCTKLKCSSLRLI 219

Query: 269 ERGNMTCLHSAK-AFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHL 327
           E G     H  K  ++      F C E + L G +++QC   G W   +PVC+  + +  
Sbjct: 220 ENGYF---HPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEGRRNRCP 275

Query: 328 EAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC----EA 383
             P           T + +G     EC+  + + G   +RC D G W+ P P C    E 
Sbjct: 276 PPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCED-GKWTEP-PKCIEGQEK 333

Query: 384 ISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC 443
           ++CE  E P   +   +   + +      ++ C  G++L G++ + C N G+WT P P C
Sbjct: 334 VACE--EPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-NRGKWTLP-PEC 389

Query: 444 QALQCQDLPVPNEARVNCSHP------------FGAFRYQSVCSFTCNEGLLLVGASVLQ 491
                       E   NC HP              ++   S   + CNE  LL G+ + +
Sbjct: 390 V-----------ENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISR 438

Query: 492 CLATGNWNSVPPECQAIPCTPLLS--PQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGP 549
           C   G W+S PP C   PCT  +    +N      +  G   +     F+C +GY LS  
Sbjct: 439 C-EQGKWSS-PPVCLE-PCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPL 495

Query: 550 ERLD---------------CTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNV 594
             L                CTR     +S  MC +   P L    +  +  S T   +  
Sbjct: 496 TPLSELSVQCNRGEVKYPLCTRK----ESKGMCTS---PPLI---KHGVIISSTVDTYEN 545

Query: 595 GSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTC 629
           GS+  + C +   LEG     C   G W+ TPP C
Sbjct: 546 GSSVEYRCFDHHFLEGSREAYC-LDGMWT-TPPLC 578



 Score =  103 bits (256), Expect = 9e-22
 Identities = 108/424 (25%), Positives = 169/424 (39%), Gaps = 44/424 (10%)

Query: 352 FECQPGYRV---RGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQY 408
           F C  GY     R  +   C   G WS P P C     +P  S  +     S     ++ 
Sbjct: 57  FFCLAGYTTESGRQEEQTTCTTEG-WS-PEPRCFKKCTKPDLSNGY----ISDVKLLYKI 110

Query: 409 DTNCSFRCAEGFMLRGA---DIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPF 465
             N  + CA G+   G    ++V+C + G W++  P C+  + +    P     N S   
Sbjct: 111 QENMRYGCASGYKTTGGKDEEVVQCLSDG-WSSQ-PTCRK-EHETCLAPELYNGNYSTTQ 167

Query: 466 GAFRYQSVCSFTCNEGLLLVGASV---LQCLATGNWNSVPPECQAIPCTPLLSPQNGTMT 522
             F+ +    + C  G    G      ++CL  G W S+ P+C  + C+ L   +NG   
Sbjct: 168 KTFKVKDKVQYECATGYYTAGGKKTEEVECLTYG-W-SLTPKCTKLKCSSLRLIENGYFH 225

Query: 523 CVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEA--IKCPELFAPEQ 580
            V+           QF C E Y LSG + + C   G W    P+CE    +CP    P  
Sbjct: 226 PVKQTYEEG--DVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEGRRNRCPPPPLPIN 282

Query: 581 GSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGV 640
             +    T   +  G   H  C+  F++ G   + C   G+W+  PP C  I        
Sbjct: 283 SKIQTHST--TYRHGEIVHIECELNFEIHGSAEIRC-EDGKWT-EPPKC--IEGQEKVAC 336

Query: 641 QCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACR 700
           + P     G   +    H   +       + C +G+ L G + ++C   G+WT + P C 
Sbjct: 337 EEPPFIENGAANL----HSKIYYNGDKVTYACKSGYLLHGSNEITCN-RGKWT-LPPEC- 389

Query: 701 AVKCSELHVNKPIAMN---CSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTT 757
            V+ +E   + P+ MN      +  +++ GS   + C E  LL GS  + C E G WS+ 
Sbjct: 390 -VENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKWSSP 447

Query: 758 VPTC 761
            P C
Sbjct: 448 -PVC 450


>gi|153266841 apolipoprotein H precursor [Homo sapiens]
          Length = 345

 Score =  117 bits (292), Expect = 6e-26
 Identities = 75/249 (30%), Positives = 107/249 (42%), Gaps = 12/249 (4%)

Query: 330 PSEGTMDCVHPL-TAFAYGSSCKFECQPGYRVR-GLDMLRCIDSGHWSAPLPTCEAISCE 387
           P +     V PL T +  G    + C+PGY  R G+    C  +G W  P+ T   + C 
Sbjct: 26  PDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLW--PINT---LKCT 80

Query: 388 PLESPVHGSMD-CSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQAL 446
           P   P  G ++  +     F+Y    SF C  GF L GAD  +C   G+W+   PVC  +
Sbjct: 81  PRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPI 140

Query: 447 QCQDLPVPNEARVNCSHPFGAFR--YQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPE 504
            C    +P  A +    P       Y+    F C     + G   + C   GNW  + PE
Sbjct: 141 ICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKL-PE 199

Query: 505 CQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSP 564
           C+ + C     P NG +       +  YK    F C +GYSL GPE ++CT+ G W+  P
Sbjct: 200 CREVKCPFPSRPDNGFVN-YPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMP 258

Query: 565 PMCEAIKCP 573
               + K P
Sbjct: 259 SCKASCKVP 267



 Score =  109 bits (272), Expect = 1e-23
 Identities = 65/224 (29%), Positives = 100/224 (44%), Gaps = 10/224 (4%)

Query: 225 QCSFHCTDGY-QVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQ 283
           + ++ C  GY    G  K  C  +G+W     +C    CP   I E G +        F+
Sbjct: 46  EITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYT----TFE 101

Query: 284 HQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTA 343
           + ++ SFSC  GF L G +  +CT  G W+   PVC  + C     P+  T+    P   
Sbjct: 102 YPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAG 161

Query: 344 --FAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSP 401
               Y  +  FEC P + + G D + C   G+W+  LP C  + C     P +G ++  P
Sbjct: 162 NNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPFPSRPDNGFVN-YP 219

Query: 402 SLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQA 445
           +     Y    +F C +G+ L G + + C  LG W+A  P C+A
Sbjct: 220 AKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSCKA 262



 Score =  109 bits (272), Expect = 1e-23
 Identities = 67/229 (29%), Positives = 98/229 (42%), Gaps = 14/229 (6%)

Query: 413 SFRCAEGFMLRGADIVR---CDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFR 469
           ++ C  G++ RG   +R   C   G W      C    C    +     V     +  F 
Sbjct: 48  TYSCKPGYVSRGG--MRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVR----YTTFE 101

Query: 470 YQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPL-- 527
           Y +  SF+CN G  L GA   +C   G W+   P C  I C P   P   T+   +P   
Sbjct: 102 YPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAG 161

Query: 528 GSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSD 587
            +S Y+ T  F C   +++ G + + CT  G WT  P  C  +KCP    P+ G ++   
Sbjct: 162 NNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPE-CREVKCPFPSRPDNGFVN-YP 219

Query: 588 TRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLP 636
            +          F C +G+ L+GP  +ECT  G WSA  P+CK    +P
Sbjct: 220 AKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAM-PSCKASCKVP 267



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 67/248 (27%), Positives = 105/248 (42%), Gaps = 27/248 (10%)

Query: 538 FICDEGY-SLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGS 596
           + C  GY S  G  +  C  +G W  +   C    CP     E G++  +     F   +
Sbjct: 49  YSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTT----FEYPN 104

Query: 597 TCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCR 656
           T  FSC+ GF L G ++ +CT  G+WS   P C  I   P      P++ T     +Y  
Sbjct: 105 TISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPP------PSIPTFATLRVYKP 158

Query: 657 HHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMN 716
                  +  T  F C     + G+ T++C   G WT + P CR VKC       P    
Sbjct: 159 SAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKL-PECREVKC-------PFPSR 210

Query: 717 CSNLWGNFS------YGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAG-PLTIQ 769
             N + N+       Y    +F C +G  L+G  +  C + G+WS  +P+C+A   + ++
Sbjct: 211 PDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMPSCKASCKVPVK 269

Query: 770 EALTYFGG 777
           +A   + G
Sbjct: 270 KATVVYQG 277



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 59/222 (26%), Positives = 91/222 (40%), Gaps = 10/222 (4%)

Query: 289 SFSCEEGF-ALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYG 347
           ++SC+ G+ +  G     C  +G+W      C    C        G +      T F Y 
Sbjct: 48  TYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVR----YTTFEYP 103

Query: 348 SSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDC-SPSL-RA 405
           ++  F C  G+ + G D  +C + G WS  LP C  I C P   P   ++    PS    
Sbjct: 104 NTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNN 163

Query: 406 FQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPF 465
             Y     F C     + G D + C   G WT   P C+ ++C     P+   VN     
Sbjct: 164 SLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPFPSRPDNGFVNYPAK- 221

Query: 466 GAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQA 507
               Y+   +F C++G  L G   ++C   GNW+++ P C+A
Sbjct: 222 PTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAM-PSCKA 262



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 51/181 (28%), Positives = 81/181 (44%), Gaps = 6/181 (3%)

Query: 209 VLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIP 268
           +L N +     F + +  SF C  G+ +NG    +C   G W+ + P C    CPP  IP
Sbjct: 89  ILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIP 148

Query: 269 ERGNMTCLHSAKAFQ--HQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQH 326
               +     +      ++ +  F C    A+ G + + CT  G WT   P C+ V+C  
Sbjct: 149 TFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPF 207

Query: 327 LEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISC 386
              P  G ++     T + Y     F C  GY + G + + C   G+WSA +P+C+A SC
Sbjct: 208 PSRPDNGFVNYPAKPTLY-YKDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSCKA-SC 264

Query: 387 E 387
           +
Sbjct: 265 K 265



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 63/235 (26%), Positives = 98/235 (41%), Gaps = 28/235 (11%)

Query: 475 SFTCNEGLLLVGAS-VLQCLATGNWNSVPPECQAIPCTPLLSP-----QNGTMTCVQPLG 528
           +++C  G +  G      C  TG W         + CTP + P     +NG +       
Sbjct: 48  TYSCKPGYVSRGGMRKFICPLTGLW-----PINTLKCTPRVCPFAGILENGAVRYT---- 98

Query: 529 SSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDT 588
           +  Y +T  F C+ G+ L+G +   CT  G+W+   P+C  I CP    P   +L     
Sbjct: 99  TFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKP 158

Query: 589 RGEFN--VGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALT 646
               N     T  F C     + G + + CTT G W+  P  C+         V+CP  +
Sbjct: 159 SAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPE-CRE--------VKCPFPS 209

Query: 647 TPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRA 701
            P  G +     P T  +     FGC+ G++L G   + C   G W+A+ P+C+A
Sbjct: 210 RPDNGFVNYPAKP-TLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAM-PSCKA 262



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 49/180 (27%), Positives = 66/180 (36%), Gaps = 28/180 (15%)

Query: 592 FNVGSTCHFSCDNGFKLEGP-NNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQ 650
           +  G    +SC  G+   G      C  +G W      C       TP V CP       
Sbjct: 41  YEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKC-------TPRV-CPFAGILEN 92

Query: 651 GTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKC------ 704
           G +       TF +  T  F CN GF L G  +  C   G+W+   P C  + C      
Sbjct: 93  GAVRYT----TFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIP 148

Query: 705 --SELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762
             + L V KP A N      N  Y     F CL    + G+    C  +G+W T +P C+
Sbjct: 149 TFATLRVYKPSAGN------NSLYRDTAVFECLPQHAMFGNDTITCTTHGNW-TKLPECR 201



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 32/103 (31%), Positives = 48/103 (46%), Gaps = 15/103 (14%)

Query: 173 ECLET---IGNYTCSCYPGFYG-----PECEYVRECGELELPQHVLMNCSHPLG-NFSFN 223
           ECL      GN T +C    +G     PEC  V+ C     P +  +N  +P      + 
Sbjct: 173 ECLPQHAMFGNDTITCTT--HGNWTKLPECREVK-CPFPSRPDNGFVN--YPAKPTLYYK 227

Query: 224 SQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLK 266
            + +F C DGY ++GP ++EC   G W +  P C A+   P+K
Sbjct: 228 DKATFGCHDGYSLDGPEEIECTKLGNW-SAMPSCKASCKVPVK 269


>gi|62739188 complement factor H isoform b precursor [Homo sapiens]
          Length = 449

 Score =  103 bits (258), Expect = 5e-22
 Identities = 109/423 (25%), Positives = 170/423 (40%), Gaps = 48/423 (11%)

Query: 224 SQCSFHCTDGYQVNGPSKLECLASGIWTNKPP--QCLAAQCPPLKIPERGNMTCLHSAKA 281
           +Q  + C  GY+  G   + C   G W    P  +C    C        G  T L     
Sbjct: 46  TQAIYKCRPGYRSLGNVIMVC-RKGEWVALNPLRKCQKRPCGHPGDTPFGTFT-LTGGNV 103

Query: 282 FQHQSSCSFSCEEGFALVGP-EVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTM--DCV 338
           F++     ++C EG+ L+G     +C   G WT   P+C+ V+C  + AP  G +    +
Sbjct: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAM 162

Query: 339 HPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLE----SPVH 394
            P   + +G + +F C  GY++ G + + C D G WS   P C  ISC+  +    SP+ 
Sbjct: 163 EPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS 222

Query: 395 GSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVP 454
             +    + R FQY  N  +  +E    RG  +  C   G W  P P C+   C +  +P
Sbjct: 223 QKIIYKENER-FQYKCNMGYEYSE----RGDAV--CTESG-W-RPLPSCEEKSCDNPYIP 273

Query: 455 N--EARVNCSHPFGAFRYQSVCSFTCNEGLL-LVGASVLQCLATGNWNSVP-PECQAIPC 510
           N   + +   H  G        ++ C  G       +  +C +TG W  +P P C   PC
Sbjct: 274 NGDYSPLRIKHRTG-----DEITYQCRNGFYPATRGNTAKCTSTG-W--IPAPRCTLKPC 325

Query: 511 TPLLSPQNGTM--TCVQPLGSSSYKSTCQFICDEGY---SLSGPERLDCTRSGRWTDSPP 565
                   G       +P    +      + CDE +   S S  + + CT+ G W+ + P
Sbjct: 326 DYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP 384

Query: 566 MCEAIKCPELFAPEQGSLDCSDTRG-EFNVGSTCHFSCDNGFKL-EGPNNVECTTSGRWS 623
                  P L   E G    +   G +F  G +   +C  G+ L +    V C  +G WS
Sbjct: 385 CLRKCYFPYL---ENG---YNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WS 437

Query: 624 ATP 626
            TP
Sbjct: 438 PTP 440



 Score =  103 bits (256), Expect = 9e-22
 Identities = 120/459 (26%), Positives = 173/459 (37%), Gaps = 46/459 (10%)

Query: 318 VCKAVQCQHLEAPSEGTMDCVHPLTAFAY--GSSCKFECQPGYRVRGLDMLRCIDSGHWS 375
           +C A  C  L  P   T       +   Y  G+   ++C+PGYR  G  ++ C   G W 
Sbjct: 15  ICVAEDCNELP-PRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWV 72

Query: 376 A--PLPTCEAISC-EPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVR-CD 431
           A  PL  C+   C  P ++P  G+   +     F+Y     + C EG+ L G    R CD
Sbjct: 73  ALNPLRKCQKRPCGHPGDTP-FGTFTLTGG-NVFEYGVKAVYTCNEGYQLLGEINYRECD 130

Query: 432 NLGQWTAPAPVCQALQCQDLPVPNEARV--NCSHPFGAFRYQSVCSFTCNEGLLLVGASV 489
             G WT   P+C+ ++C  +  P   ++  +   P   + +     F CN G  + G   
Sbjct: 131 TDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEE 189

Query: 490 LQCLATGNWNSVPPECQAIPCTPLLSPQ--NGTMTCVQPLGSSSYKSTCQFICDEGYSLS 547
           + C   G W+   P+C  I C    SP   NG+    + +   + +   Q+ C+ GY  S
Sbjct: 190 MHCSDDGFWSKEKPKCVEISCK---SPDVINGSPISQKIIYKENER--FQYKCNMGYEYS 244

Query: 548 GPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGF- 606
                 CT SG W    P CE   C   + P     D S  R +   G    + C NGF 
Sbjct: 245 ERGDAVCTESG-WRPL-PSCEEKSCDNPYIPNG---DYSPLRIKHRTGDEITYQCRNGFY 299

Query: 607 KLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNT 666
                N  +CT++G W   P     +     P ++   L        Y    P   G   
Sbjct: 300 PATRGNTAKCTSTG-WIPAPRCT--LKPCDYPDIKHGGLYHENMRRPY---FPVAVGKYY 353

Query: 667 TCYFGCNAGFTLIGDS---TLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGN 723
           + Y  C+  F     S    + C   G W+   P  R  KC   ++      N       
Sbjct: 354 SYY--CDEHFETPSGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYNQNHGR---K 405

Query: 724 FSYGSICSFHCLEGQLLNGSAQT-ACQENGHWSTTVPTC 761
           F  G      C  G  L  +  T  C ENG WS T P C
Sbjct: 406 FVQGKSIDVACHPGYALPKAQTTVTCMENG-WSPT-PRC 442



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 84/365 (23%), Positives = 136/365 (37%), Gaps = 48/365 (13%)

Query: 220 FSFNSQCSFHCTDGYQVNGP-SKLECLASGIWTNKPPQCLAAQCPPLKIPERGNM--TCL 276
           F +  +  + C +GYQ+ G  +  EC   G WTN  P C   +C P+  PE G +  + +
Sbjct: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAM 162

Query: 277 HSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMD 336
              + +    +  F C  G+ + G E + C+  G W+   P C  + C   ++P      
Sbjct: 163 EPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISC---KSPDVINGS 219

Query: 337 CVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGS 396
            +     +      +++C  GY         C +SG W  PLP+CE  SC   ++P   +
Sbjct: 220 PISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-W-RPLPSCEEKSC---DNPYIPN 274

Query: 397 MDCSPSLRAFQYDTNCSFRCAEGF--MLRGADIVRCDNLGQWTAPAPVCQALQCQ--DLP 452
            D SP     +     +++C  GF    RG +  +C + G W  PAP C    C   D+ 
Sbjct: 275 GDYSPLRIKHRTGDEITYQCRNGFYPATRG-NTAKCTSTG-W-IPAPRCTLKPCDYPDIK 331

Query: 453 VPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASV---LQCLATGNWNSVPPECQAIP 509
                  N   P+         S+ C+E       S    + C   G W+       A+P
Sbjct: 332 HGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WS------PAVP 384

Query: 510 CTPLLSPQNGTMTCVQPLGSSSYK----------STCQFICDEGYSLSGPERLDCTRSGR 559
           C            C  P   + Y            +    C  GY+L   +         
Sbjct: 385 C---------LRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG 435

Query: 560 WTDSP 564
           W+ +P
Sbjct: 436 WSPTP 440



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 47/200 (23%), Positives = 81/200 (40%), Gaps = 16/200 (8%)

Query: 192 PECEYVRECGELELPQH--VLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGI 249
           P CE V+ C  +  P++  ++ +   P   + F     F C  GY++ G  ++ C   G 
Sbjct: 139 PICEVVK-CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGF 197

Query: 250 WTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTAS 309
           W+ + P+C+   C   K P+  N + +     ++      + C  G+         CT S
Sbjct: 198 WSKEKPKCVEISC---KSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTES 254

Query: 310 GVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGY--RVRGLDMLR 367
           G W  P P C+   C +   P+    D          G    ++C+ G+    RG +  +
Sbjct: 255 G-W-RPLPSCEEKSCDNPYIPNG---DYSPLRIKHRTGDEITYQCRNGFYPATRG-NTAK 308

Query: 368 CIDSGHWSAPLPTCEAISCE 387
           C  +G W  P P C    C+
Sbjct: 309 CTSTG-W-IPAPRCTLKPCD 326



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 29/104 (27%), Positives = 44/104 (42%), Gaps = 4/104 (3%)

Query: 661 TFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNL 720
           T+   T   + C  G+  +G+  + CR  G+W A+ P  +  K    H         +  
Sbjct: 41  TYPEGTQAIYKCRPGYRSLGNVIMVCR-KGEWVALNPLRKCQKRPCGHPGDTPFGTFTLT 99

Query: 721 WGN-FSYGSICSFHCLEG-QLLNGSAQTACQENGHWSTTVPTCQ 762
            GN F YG    + C EG QLL       C  +G W+  +P C+
Sbjct: 100 GGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICE 142


>gi|5454086 sushi-repeat-containing protein, X-linked [Homo sapiens]
          Length = 464

 Score =  100 bits (250), Expect = 4e-21
 Identities = 79/280 (28%), Positives = 113/280 (40%), Gaps = 41/280 (14%)

Query: 511 TPLLSP---QNGTMTCVQPLGS---SSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSP 564
           TP  SP   + G + C  P G    ++  + C   C +GY L G   L C  + RW+D  
Sbjct: 54  TPWCSPIKVKYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV 113

Query: 565 PMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSA 624
            +C+  +CP L  P  G   C D    FN  S C + C  G+ L+G   V C  +  WS 
Sbjct: 114 -ICKQKRCPTLAMPANGGFKCVDG-AYFN--SRCEYYCSPGYTLKGERTVTCMDNKAWSG 169

Query: 625 TPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTL 684
            P +C     +  P ++CP++            +  T   +     G +    ++ D  L
Sbjct: 170 RPASC---VDMEPPRIKCPSVKE-----RIAEPNKLTVRVSWETPEGRDTADGILTDVIL 221

Query: 685 SCRPSG----------QWTAVTPA-----------CRAVKCSELHVNKPIAMNCSNLWGN 723
              P G          Q+T    A            R  +C +L+  +   M CS+   N
Sbjct: 222 KGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDN 281

Query: 724 FSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQA 763
             YG+ C F C+ G  L GS    CQ N  WS T PTC A
Sbjct: 282 --YGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCAA 319



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 62/263 (23%), Positives = 96/263 (36%), Gaps = 28/263 (10%)

Query: 459 VNCSHPFGAFRYQSV---CSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLS 515
           V C  P G +   ++   C   C +G  L G+S+L C +   W+     C+   C  L  
Sbjct: 67  VYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAM 125

Query: 516 PQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPEL 575
           P NG   CV     + + S C++ C  GY+L G   + C  +  W+  P  C  ++ P +
Sbjct: 126 PANGGFKCVD---GAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRI 182

Query: 576 FAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKL----------------EGPNNVECTTS 619
             P          +    V        D    +                EG + ++ T  
Sbjct: 183 KCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVY 242

Query: 620 GRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLI 679
            R +    TCK    +     +C  L  P  G M C      +G   TC F C  G+ L 
Sbjct: 243 DR-AENKGTCKFRVKVRVK--RCGKLNAPENGYMKCSSDGDNYG--ATCEFSCIGGYELQ 297

Query: 680 GDSTLSCRPSGQWTAVTPACRAV 702
           G     C+ +  W+   P C A+
Sbjct: 298 GSPARVCQSNLAWSGTEPTCAAM 320



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 59/271 (21%), Positives = 108/271 (39%), Gaps = 31/271 (11%)

Query: 262 CPPLKIPERGNMTCLHSAKAFQHQS---SCSFSCEEGFALVGPEVVQCTASGVWTAPAPV 318
           C P+K+ + G++ C      +   +    C   C++G+ L G  ++ C ++  W+    +
Sbjct: 57  CSPIKV-KYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-I 114

Query: 319 CKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPL 378
           CK  +C  L  P+ G   CV       + S C++ C PGY ++G   + C+D+  WS   
Sbjct: 115 CKQKRCPTLAMPANGGFKCVD---GAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRP 171

Query: 379 PTCEAISCEPLESPVHGSMDCSPSLRAFQ--YDTNCSFRCAEGFML--------RGADIV 428
            +C  +    ++ P        P+    +  ++T      A+G +          G++  
Sbjct: 172 ASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFP 231

Query: 429 RCDNLGQWTA-----PAPVC------QALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFT 477
             D+  Q+T          C      +  +C  L  P    + CS       Y + C F+
Sbjct: 232 EGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSS--DGDNYGATCEFS 289

Query: 478 CNEGLLLVGASVLQCLATGNWNSVPPECQAI 508
           C  G  L G+    C +   W+   P C A+
Sbjct: 290 CIGGYELQGSPARVCQSNLAWSGTEPTCAAM 320



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 33/122 (27%), Positives = 55/122 (45%), Gaps = 7/122 (5%)

Query: 213 CSHPLGNF---SFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPE 269
           C  P G +   +  ++C   C  GY+++G S L C ++  W++K   C   +CP L +P 
Sbjct: 69  CRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPA 127

Query: 270 RGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEA 329
            G   C+  A      S C + C  G+ L G   V C  +  W+     C  ++   ++ 
Sbjct: 128 NGGFKCVDGA---YFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKC 184

Query: 330 PS 331
           PS
Sbjct: 185 PS 186



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 50/209 (23%), Positives = 84/209 (40%), Gaps = 26/209 (12%)

Query: 198 RECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQC 257
           + C  L +P +    C   +    FNS+C ++C+ GY + G   + C+ +  W+ +P  C
Sbjct: 118 KRCPTLAMPANGGFKC---VDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASC 174

Query: 258 LAAQCPPLKIP-------ERGNMTCLHSAKAFQHQSSCSFSCEEGFAL---------VGP 301
           +  + P +K P       E   +T   S +  + + +      +              G 
Sbjct: 175 VDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGD 234

Query: 302 EVVQCT----ASGVWTAPAPV-CKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQP 356
             +Q T    A    T    V  +  +C  L AP  G M C        YG++C+F C  
Sbjct: 235 HKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKC--SSDGDNYGATCEFSCIG 292

Query: 357 GYRVRGLDMLRCIDSGHWSAPLPTCEAIS 385
           GY ++G     C  +  WS   PTC A++
Sbjct: 293 GYELQGSPARVCQSNLAWSGTEPTCAAMN 321



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 40/144 (27%), Positives = 66/144 (45%), Gaps = 22/144 (15%)

Query: 559 RWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFN---VGSTCHFSCDNGFKLEGPNNVE 615
           R+ D+P  C  IK       + G + C   +G +    +G+ C   C  G++L G + + 
Sbjct: 50  RYKDTP-WCSPIKV------KYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLI 102

Query: 616 CTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAG 675
           C ++ RWS     CK          +CP L  P  G   C    G + FN+ C + C+ G
Sbjct: 103 CQSNKRWS-DKVICKQ--------KRCPTLAMPANGGFKCVD--GAY-FNSRCEYYCSPG 150

Query: 676 FTLIGDSTLSCRPSGQWTAVTPAC 699
           +TL G+ T++C  +  W+    +C
Sbjct: 151 YTLKGERTVTCMDNKAWSGRPASC 174



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 20/63 (31%), Positives = 31/63 (49%), Gaps = 2/63 (3%)

Query: 197 VRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQ 256
           V+ CG+L  P++  M CS    N+   + C F C  GY++ G     C ++  W+   P 
Sbjct: 259 VKRCGKLNAPENGYMKCSSDGDNYG--ATCEFSCIGGYELQGSPARVCQSNLAWSGTEPT 316

Query: 257 CLA 259
           C A
Sbjct: 317 CAA 319


>gi|7657619 sushi-repeat-containing protein, X-linked 2 [Homo
           sapiens]
          Length = 465

 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 75/270 (27%), Positives = 111/270 (41%), Gaps = 34/270 (12%)

Query: 514 LSPQNGTMTCVQPLGS---SSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAI 570
           L+ Q+G  TC  P G    SS  + C+  CD G+ L G   + C  S RW+ +   C  +
Sbjct: 62  LNIQDGEATCYSPKGGNYHSSLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGTA-YCRQM 120

Query: 571 KCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCK 630
           +C  L     G+  C  T G   + S C +SC +G+ LEG  +  C   GRWS   P C 
Sbjct: 121 RCHALPFITSGTYTC--TNGVL-LDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVC- 176

Query: 631 GIASLPTPGVQCP----ALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSC 686
               +  P ++CP     +  P + T      P     +     G     TL G    S 
Sbjct: 177 --VDIDPPKIRCPHSREKMAEPEKLTARVYWDPPLVKDSAD---GTITRVTLRGPEPGSH 231

Query: 687 RPSGQ----WTAVTPA-----CRAV------KCSELHVNKPIAMNCSNLWGNFSYGSICS 731
            P G+    +TA   A     C+ +      +C  L   +   + C++   N  YG+ C 
Sbjct: 232 FPEGEHVIRYTAYDRAYNRASCKFIVKVQVRRCPTLKPPQHGYLTCTSAGDN--YGATCE 289

Query: 732 FHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
           +HC  G    G+    CQ +  WS + P C
Sbjct: 290 YHCDGGYDRQGTPSRVCQSSRQWSGSPPIC 319



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 72/287 (25%), Positives = 106/287 (36%), Gaps = 48/287 (16%)

Query: 443 CQALQCQDLPVPNEARVNCSHPFGAFRYQSV---CSFTCNEGLLLVGASVLQCLATGNWN 499
           C  L  QD          C  P G   + S+   C  +C+ G  L+G   +QCL +  W+
Sbjct: 59  CYTLNIQD------GEATCYSPKGGNYHSSLGTRCELSCDRGFRLIGRRSVQCLPSRRWS 112

Query: 500 SVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGR 559
                C+ + C  L    +GT TC   +      S C + C  GY L G     C   GR
Sbjct: 113 GTA-YCRQMRCHALPFITSGTYTCTNGV---LLDSRCDYSCSSGYHLEGDRSRICMEDGR 168

Query: 560 WTDSPPMCEAIKCPELFAPE----------------------QGSLDCSDTRGEFNVGST 597
           W+   P+C  I  P++  P                       + S D + TR        
Sbjct: 169 WSGGEPVCVDIDPPKIRCPHSREKMAEPEKLTARVYWDPPLVKDSADGTITRVTLRGPEP 228

Query: 598 -CHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCR 656
             HF        EG + +  T   R +    +CK I  +     +CP L  P  G + C 
Sbjct: 229 GSHFP-------EGEHVIRYTAYDR-AYNRASCKFIVKVQVR--RCPTLKPPQHGYLTCT 278

Query: 657 HHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVK 703
                +G   TC + C+ G+   G  +  C+ S QW+   P C  +K
Sbjct: 279 SAGDNYG--ATCEYHCDGGYDRQGTPSRVCQSSRQWSGSPPICAPMK 323



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 65/246 (26%), Positives = 96/246 (39%), Gaps = 37/246 (15%)

Query: 410 TNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFR 469
           T C   C  GF L G   V+C    +W+  A  C+ ++C  LP        C++      
Sbjct: 85  TRCELSCDRGFRLIGRRSVQCLPSRRWSGTA-YCRQMRCHALPFITSGTYTCTN---GVL 140

Query: 470 YQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQN----------- 518
             S C ++C+ G  L G     C+  G W+   P C  I    +  P +           
Sbjct: 141 LDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVCVDIDPPKIRCPHSREKMAEPEKLT 200

Query: 519 GTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSG----RWTD-----SPPMCEA 569
             +    PL   S   T   +     +L GPE       G    R+T      +   C+ 
Sbjct: 201 ARVYWDPPLVKDSADGTITRV-----TLRGPEPGSHFPEGEHVIRYTAYDRAYNRASCKF 255

Query: 570 I------KCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWS 623
           I      +CP L  P+ G L C  T    N G+TC + CD G+  +G  +  C +S +WS
Sbjct: 256 IVKVQVRRCPTLKPPQHGYLTC--TSAGDNYGATCEYHCDGGYDRQGTPSRVCQSSRQWS 313

Query: 624 ATPPTC 629
            +PP C
Sbjct: 314 GSPPIC 319



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 69/269 (25%), Positives = 103/269 (38%), Gaps = 33/269 (12%)

Query: 262 CPPLKIPERGNMTCLHSAKAFQHQSS----CSFSCEEGFALVGPEVVQCTASGVWTAPAP 317
           C  L I + G  TC +S K   + SS    C  SC+ GF L+G   VQC  S  W+  A 
Sbjct: 59  CYTLNIQD-GEATC-YSPKGGNYHSSLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGTA- 115

Query: 318 VCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAP 377
            C+ ++C  L   + GT  C + +      S C + C  GY + G     C++ G WS  
Sbjct: 116 YCRQMRCHALPFITSGTYTCTNGVLL---DSRCDYSCSSGYHLEGDRSRICMEDGRWSGG 172

Query: 378 LPTCEAISCEPLESPVHGSMDCSP-SLRAFQY-DTNCSFRCAEGFMLR--------GADI 427
            P C  I    +  P        P  L A  Y D       A+G + R        G+  
Sbjct: 173 EPVCVDIDPPKIRCPHSREKMAEPEKLTARVYWDPPLVKDSADGTITRVTLRGPEPGSHF 232

Query: 428 VRCDNLGQWTAPAPV-----------CQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSF 476
              +++ ++TA                Q  +C  L  P    + C+       Y + C +
Sbjct: 233 PEGEHVIRYTAYDRAYNRASCKFIVKVQVRRCPTLKPPQHGYLTCTS--AGDNYGATCEY 290

Query: 477 TCNEGLLLVGASVLQCLATGNWNSVPPEC 505
            C+ G    G     C ++  W+  PP C
Sbjct: 291 HCDGGYDRQGTPSRVCQSSRQWSGSPPIC 319



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 60/253 (23%), Positives = 96/253 (37%), Gaps = 29/253 (11%)

Query: 218 GNF--SFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTC 275
           GN+  S  ++C   C  G+++ G   ++CL S  W+     C   +C  L     G  TC
Sbjct: 77  GNYHSSLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGTA-YCRQMRCHALPFITSGTYTC 135

Query: 276 LHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAP-SEGT 334
            +        S C +SC  G+ L G     C   G W+   PVC  +    +  P S   
Sbjct: 136 TNGVLL---DSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVCVDIDPPKIRCPHSREK 192

Query: 335 MDCVHPLTAFAY-----------GSSCKFEC---QPGYRV-RGLDMLR--CIDSGHWSAP 377
           M     LTA  Y           G+  +      +PG     G  ++R    D  +  A 
Sbjct: 193 MAEPEKLTARVYWDPPLVKDSADGTITRVTLRGPEPGSHFPEGEHVIRYTAYDRAYNRAS 252

Query: 378 ---LPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLG 434
              +   +   C  L+ P HG + C+ +     Y   C + C  G+  +G     C +  
Sbjct: 253 CKFIVKVQVRRCPTLKPPQHGYLTCTSA--GDNYGATCEYHCDGGYDRQGTPSRVCQSSR 310

Query: 435 QWTAPAPVCQALQ 447
           QW+   P+C  ++
Sbjct: 311 QWSGSPPICAPMK 323



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 67/309 (21%), Positives = 109/309 (35%), Gaps = 44/309 (14%)

Query: 128 NEDCVEIYIKS-PSAPG------KWNDEHCLKKKHALCYTASCQDMSCSKQGEC------ 174
           +E   E+Y +  P AP       +W     ++   A CY+    +   S    C      
Sbjct: 34  DESYNEVYAEEVPQAPALDYRVPRWCYTLNIQDGEATCYSPKGGNYHSSLGTRCELSCDR 93

Query: 175 -LETIGNYTCSCYPGFYGPECEYVRE--CGELELPQHVLMNCSHPLGNFSFNSQCSFHCT 231
               IG  +  C P        Y R+  C  L         C++ +     +S+C + C+
Sbjct: 94  GFRLIGRRSVQCLPSRRWSGTAYCRQMRCHALPFITSGTYTCTNGV---LLDSRCDYSCS 150

Query: 232 DGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIP---ERGNMTCLHSAKAFQHQSSC 288
            GY + G     C+  G W+   P C+    P ++ P   E+       +A+ +      
Sbjct: 151 SGYHLEGDRSRICMEDGRWSGGEPVCVDIDPPKIRCPHSREKMAEPEKLTARVYWDPPLV 210

Query: 289 SFSCEEGFALV---GPE----------VVQCTASGVWTAPAPVCKAV------QCQHLEA 329
             S +     V   GPE          V++ TA       A  CK +      +C  L+ 
Sbjct: 211 KDSADGTITRVTLRGPEPGSHFPEGEHVIRYTAYDRAYNRAS-CKFIVKVQVRRCPTLKP 269

Query: 330 PSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPL 389
           P  G + C        YG++C++ C  GY  +G     C  S  WS   P C  +     
Sbjct: 270 PQHGYLTCTS--AGDNYGATCEYHCDGGYDRQGTPSRVCQSSRQWSGSPPICAPMKINVN 327

Query: 390 ESPVHGSMD 398
            +   G +D
Sbjct: 328 VNSAAGLLD 336


>gi|38045915 pregnancy-associated plasma protein A preproprotein [Homo
            sapiens]
          Length = 1627

 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 72/287 (25%), Positives = 111/287 (38%), Gaps = 38/287 (13%)

Query: 199  ECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVN------------GPSKLECLA 246
            +C EL + ++  +NCS    +    +QC+  C  GY +             GPS      
Sbjct: 1214 DCPELAV-ENASLNCSS--SDRYHGAQCTVSCRTGYVLQIRRDDELIKSQTGPSVTVTCT 1270

Query: 247  SGIWTNKPPQCLAAQCPPLKIPERGNM--TCLHSAKAFQHQSSCSFSCEEGFALVGPE-V 303
             G W NK   C    C    IP+   +        +     S CSF C     L G   +
Sbjct: 1271 EGKW-NKQVACEPVDC---SIPDHHQVYAASFSCPEGTTFGSQCSFQCRHPAQLKGNNSL 1326

Query: 304  VQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGL 363
            + C   G+W+ P  +C+ +       P+               GS CK++C+PGY V G 
Sbjct: 1327 LTCMEDGLWSFPEALCELMCLAPPPVPNADLQTARCRENKHKVGSFCKYKCKPGYHVPGS 1386

Query: 364  D--------MLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFR 415
                       +C   G W      C  ++C+P     HG   C+     FQ+++ C  +
Sbjct: 1387 SRKSKKRAFKTQCTQDGSWQE--GACVPVTCDPPPPKFHGLYQCT---NGFQFNSECRIK 1441

Query: 416  CAEGFMLR--GADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVN 460
            C +    +  G++++ C   G W     VCQ +Q Q   VPNE   N
Sbjct: 1442 CEDSDASQGLGSNVIHCRKDGTWNGSFHVCQEMQGQ-CSVPNELNSN 1487



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 82/327 (25%), Positives = 122/327 (37%), Gaps = 61/327 (18%)

Query: 443  CQALQCQDLPVPNEARVNCSHPFGAFRYQSV-CSFTCNEGLLL------------VGASV 489
            C+   C +L V N A +NCS    + RY    C+ +C  G +L             G SV
Sbjct: 1210 CEKTDCPELAVEN-ASLNCS---SSDRYHGAQCTVSCRTGYVLQIRRDDELIKSQTGPSV 1265

Query: 490  LQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGP 549
                  G WN     C+ + C+     Q    +   P G++ + S C F C     L G 
Sbjct: 1266 TVTCTEGKWNK-QVACEPVDCSIPDHHQVYAASFSCPEGTT-FGSQCSFQCRHPAQLKGN 1323

Query: 550  ERL-DCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFN---VGSTCHFSCDNG 605
              L  C   G W+    +CE + C  L  P   + D    R   N   VGS C + C  G
Sbjct: 1324 NSLLTCMEDGLWSFPEALCE-LMC--LAPPPVPNADLQTARCRENKHKVGSFCKYKCKPG 1380

Query: 606  FKLEGPNN--------VECTTSGRW---SATPPTCKGIASLPTPGVQCPALTTPGQGTMY 654
            + + G +          +CT  G W   +  P TC      P P            G   
Sbjct: 1381 YHVPGSSRKSKKRAFKTQCTQDGSWQEGACVPVTCDP----PPPKFH---------GLYQ 1427

Query: 655  CRHHPGTFGFNTTCYFGCNAGFTL--IGDSTLSCRPSGQWTAVTPACRAV--KCS-ELHV 709
            C +    F FN+ C   C        +G + + CR  G W      C+ +  +CS    +
Sbjct: 1428 CTNG---FQFNSECRIKCEDSDASQGLGSNVIHCRKDGTWNGSFHVCQEMQGQCSVPNEL 1484

Query: 710  NKPIAMNCSNLWGNFSYGSICSFHCLE 736
            N  + + C +    ++ GS C+  CL+
Sbjct: 1485 NSNLKLQCPD---GYAIGSECATSCLD 1508



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 70/302 (23%), Positives = 112/302 (37%), Gaps = 50/302 (16%)

Query: 380  TCEAISCEPLESPV----HGSMDCSPSLRAFQYDTNCSFRCAEGFMLR------------ 423
            +C   +CE  + P     + S++CS S R   +   C+  C  G++L+            
Sbjct: 1204 SCVHFACEKTDCPELAVENASLNCSSSDR--YHGAQCTVSCRTGYVLQIRRDDELIKSQT 1261

Query: 424  GADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARV---NCSHPFGAFRYQSVCSFTCNE 480
            G  +      G+W      C+ + C    +P+  +V   + S P G   + S CSF C  
Sbjct: 1262 GPSVTVTCTEGKWNKQV-ACEPVDCS---IPDHHQVYAASFSCPEGT-TFGSQCSFQCRH 1316

Query: 481  GLLLVGA-SVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFI 539
               L G  S+L C+  G W+     C+ +   P   P     T           S C++ 
Sbjct: 1317 PAQLKGNNSLLTCMEDGLWSFPEALCELMCLAPPPVPNADLQTARCRENKHKVGSFCKYK 1376

Query: 540  CDEGYSLSGPER--------LDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGE 591
            C  GY + G  R          CT+ G W +    C  + C        G   C++    
Sbjct: 1377 CKPGYHVPGSSRKSKKRAFKTQCTQDGSWQEG--ACVPVTCDPPPPKFHGLYQCTN---G 1431

Query: 592  FNVGSTCHFSCDNGFKLE--GPNNVECTTSGRWSATPPTC---KGIASLPTP-----GVQ 641
            F   S C   C++    +  G N + C   G W+ +   C   +G  S+P        +Q
Sbjct: 1432 FQFNSECRIKCEDSDASQGLGSNVIHCRKDGTWNGSFHVCQEMQGQCSVPNELNSNLKLQ 1491

Query: 642  CP 643
            CP
Sbjct: 1492 CP 1493



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 74/330 (22%), Positives = 116/330 (35%), Gaps = 45/330 (13%)

Query: 458  RVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQ 517
            RV+ S P  A    ++ SF   + + L      +  +    + V   C+   C P L+ +
Sbjct: 1163 RVSFSSPLVAISGVALRSFDNFDPVTLSSCQRGETYSPAEQSCVHFACEKTDC-PELAVE 1221

Query: 518  NGTMTCVQPLGSSSYKSTCQFICDEGYSL------------SGPERLDCTRSGRWTDSPP 565
            N ++ C        + + C   C  GY L            +GP        G+W +   
Sbjct: 1222 NASLNCSS--SDRYHGAQCTVSCRTGYVLQIRRDDELIKSQTGPSVTVTCTEGKW-NKQV 1278

Query: 566  MCEAIKC--PELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNV-ECTTSGRW 622
             CE + C  P+       S  C +       GS C F C +  +L+G N++  C   G W
Sbjct: 1279 ACEPVDCSIPDHHQVYAASFSCPEGT---TFGSQCSFQCRHPAQLKGNNSLLTCMEDGLW 1335

Query: 623  SATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDS 682
            S     C+ +   P P      +      T  CR +    G  + C + C  G+ + G S
Sbjct: 1336 SFPEALCELMCLAPPP------VPNADLQTARCRENKHKVG--SFCKYKCKPGYHVPGSS 1387

Query: 683  TLS--------CRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHC 734
              S        C   G W     AC  V C            C+N    F + S C   C
Sbjct: 1388 RKSKKRAFKTQCTQDGSWQE--GACVPVTCDPPPPKFHGLYQCTN---GFQFNSECRIKC 1442

Query: 735  LEGQLLNGSAQTA--CQENGHWSTTVPTCQ 762
             +     G       C+++G W+ +   CQ
Sbjct: 1443 EDSDASQGLGSNVIHCRKDGTWNGSFHVCQ 1472



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 47/175 (26%), Positives = 64/175 (36%), Gaps = 34/175 (19%)

Query: 215  HPLGNFSFNSQCSFHCTDGYQVNGPS--------KLECLASGIWTNKPPQCLAAQCPPLK 266
            H +G+F     C + C  GY V G S        K +C   G W  +   C+   C P  
Sbjct: 1367 HKVGSF-----CKYKCKPGYHVPGSSRKSKKRAFKTQCTQDGSW--QEGACVPVTCDPPP 1419

Query: 267  IPERGNMTCLHSAKAFQHQSSCSFSCEEGFAL--VGPEVVQCTASGVWTAPAPVCKAVQC 324
                G   C +    FQ  S C   CE+  A   +G  V+ C   G W     VC+ +Q 
Sbjct: 1420 PKFHGLYQCTNG---FQFNSECRIKCEDSDASQGLGSNVIHCRKDGTWNGSFHVCQEMQG 1476

Query: 325  QHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLP 379
            Q    P+E               S+ K +C  GY +       C+D    S  LP
Sbjct: 1477 Q-CSVPNE-------------LNSNLKLQCPDGYAIGSECATSCLDHNSESIILP 1517



 Score = 30.0 bits (66), Expect = 9.2
 Identities = 15/34 (44%), Positives = 19/34 (55%), Gaps = 6/34 (17%)

Query: 727 GSICSFHCLEGQLL-----NGSAQTACQENGHWS 755
           GS C   CLEG++L     N S+   C  +GHWS
Sbjct: 707 GSACHL-CLEGRILVQYASNASSPMPCSPSGHWS 739


>gi|27502411 CD46 antigen, complement regulatory protein isoform 6
           precursor [Homo sapiens]
          Length = 369

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 66/240 (27%), Positives = 92/240 (38%), Gaps = 30/240 (12%)

Query: 540 CDEGYSLSGP--ERLDCTRSGRWTD-SPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGS 596
           C +GY    P      C R+  W   S   C    CP +  P  G        G +  G 
Sbjct: 64  CKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQ--AVPANGTYEFGY 121

Query: 597 TCHFSCDNGFKLEGPNNVECTTSGR---WSATPPTCKGIASLPTPGVQCPALTTPGQGTM 653
             HF C+ G+ L G   + C   G    WS  PP C+ +   P P ++       G+ T 
Sbjct: 122 QMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK------NGKHTF 175

Query: 654 YCRHHPGTFGFNTTCYFGCNAG-----FTLIGDSTLSCRPSGQWTAVTPACRAVKCSELH 708
                   F +     + C+       F+LIG+ST+ C  +  W+   P C+ VKC    
Sbjct: 176 ---SEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC---- 228

Query: 709 VNKPIAMNCSNLWG---NFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGP 765
              P+  N   + G    F Y +   F C +G  L+GS    C  N  W   VP C  GP
Sbjct: 229 -RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGP 287



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 59/240 (24%), Positives = 90/240 (37%), Gaps = 18/240 (7%)

Query: 216 PLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQ---CLAAQCPPLKIPERGN 272
           P   +    +  + C  GY    P     +     T  P     C    CP ++ P  G 
Sbjct: 50  PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQ 109

Query: 273 MTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASG---VWTAPAPVCKAVQCQHLEA 329
               +    F +Q    F C EG+ L+G E++ C   G   +W+   P+C+ V C     
Sbjct: 110 AVPANGTYEFGYQMH--FICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167

Query: 330 PSEGTMDCVHPLTAFAYGSSCKFECQPG-----YRVRGLDMLRCIDSGHWSAPLPTCEAI 384
              G       +  F Y  +  + C P      + + G   + C D+  WS   P C+ +
Sbjct: 168 IKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 385 SCE-PLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC 443
            C  P+   V      S   + F Y     F C +GF L G+D + CD+   W  P P C
Sbjct: 227 KCRFPV---VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 70/287 (24%), Positives = 116/287 (40%), Gaps = 37/287 (12%)

Query: 328 EAPSEGTMDCV-HPLTAFAYGSSCKFECQPGY-RVRGLDMLRCIDSGHWSAPLP--TCEA 383
           E P+   M+ +  P   +  G    ++C+ GY  +  L      D  H   P+    C  
Sbjct: 37  EPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYR 96

Query: 384 ISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ---WTAPA 440
            +C  +  P++G     P+   +++     F C EG+ L G +I+ C+  G    W+   
Sbjct: 97  ETCPYIRDPLNGQ--AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154

Query: 441 PVCQALQCQDLPVPNEARVNCSHPFG---AFRYQSVCSFTCN-----EGLLLVGASVLQC 492
           P+C+ + C     P     N  H F     F Y    +++C+     +   L+G S + C
Sbjct: 155 PICEKVLC----TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC 210

Query: 493 LATGNWNSVPPECQAIPCT-PLLSPQNGTMTCVQPLGSSSY-KSTCQFICDEGYSLSGPE 550
                W+   PEC+ + C  P++  +NG    +   G   Y K+T  F CD+G+ L G +
Sbjct: 211 GDNSVWSRAAPECKVVKCRFPVV--ENGKQ--ISGFGKKFYYKATVMFECDKGFYLDGSD 266

Query: 551 RLDCTRSGRWTDSPPMC----------EAIKCPELFAPEQGSLDCSD 587
            + C  +  W    P C               P    PE+G LD  D
Sbjct: 267 TIVCDSNSTWDPPVPKCLKGPRPTYKPPVSNYPGYPKPEEGILDSLD 313



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 13/49 (26%), Positives = 22/49 (44%)

Query: 220 FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIP 268
           F + +   F C  G+ ++G   + C ++  W    P+CL    P  K P
Sbjct: 246 FYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPP 294


>gi|27502409 CD46 antigen, complement regulatory protein isoform 5
           precursor [Homo sapiens]
          Length = 362

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 66/240 (27%), Positives = 92/240 (38%), Gaps = 30/240 (12%)

Query: 540 CDEGYSLSGP--ERLDCTRSGRWTD-SPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGS 596
           C +GY    P      C R+  W   S   C    CP +  P  G        G +  G 
Sbjct: 64  CKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQ--AVPANGTYEFGY 121

Query: 597 TCHFSCDNGFKLEGPNNVECTTSGR---WSATPPTCKGIASLPTPGVQCPALTTPGQGTM 653
             HF C+ G+ L G   + C   G    WS  PP C+ +   P P ++       G+ T 
Sbjct: 122 QMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK------NGKHTF 175

Query: 654 YCRHHPGTFGFNTTCYFGCNAG-----FTLIGDSTLSCRPSGQWTAVTPACRAVKCSELH 708
                   F +     + C+       F+LIG+ST+ C  +  W+   P C+ VKC    
Sbjct: 176 ---SEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC---- 228

Query: 709 VNKPIAMNCSNLWG---NFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGP 765
              P+  N   + G    F Y +   F C +G  L+GS    C  N  W   VP C  GP
Sbjct: 229 -RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGP 287



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 59/240 (24%), Positives = 90/240 (37%), Gaps = 18/240 (7%)

Query: 216 PLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQ---CLAAQCPPLKIPERGN 272
           P   +    +  + C  GY    P     +     T  P     C    CP ++ P  G 
Sbjct: 50  PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQ 109

Query: 273 MTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASG---VWTAPAPVCKAVQCQHLEA 329
               +    F +Q    F C EG+ L+G E++ C   G   +W+   P+C+ V C     
Sbjct: 110 AVPANGTYEFGYQMH--FICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167

Query: 330 PSEGTMDCVHPLTAFAYGSSCKFECQPG-----YRVRGLDMLRCIDSGHWSAPLPTCEAI 384
              G       +  F Y  +  + C P      + + G   + C D+  WS   P C+ +
Sbjct: 168 IKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 385 SCE-PLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC 443
            C  P+   V      S   + F Y     F C +GF L G+D + CD+   W  P P C
Sbjct: 227 KCRFPV---VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 70/287 (24%), Positives = 116/287 (40%), Gaps = 37/287 (12%)

Query: 328 EAPSEGTMDCV-HPLTAFAYGSSCKFECQPGY-RVRGLDMLRCIDSGHWSAPLP--TCEA 383
           E P+   M+ +  P   +  G    ++C+ GY  +  L      D  H   P+    C  
Sbjct: 37  EPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYR 96

Query: 384 ISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ---WTAPA 440
            +C  +  P++G     P+   +++     F C EG+ L G +I+ C+  G    W+   
Sbjct: 97  ETCPYIRDPLNGQ--AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154

Query: 441 PVCQALQCQDLPVPNEARVNCSHPFG---AFRYQSVCSFTCN-----EGLLLVGASVLQC 492
           P+C+ + C     P     N  H F     F Y    +++C+     +   L+G S + C
Sbjct: 155 PICEKVLC----TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC 210

Query: 493 LATGNWNSVPPECQAIPCT-PLLSPQNGTMTCVQPLGSSSY-KSTCQFICDEGYSLSGPE 550
                W+   PEC+ + C  P++  +NG    +   G   Y K+T  F CD+G+ L G +
Sbjct: 211 GDNSVWSRAAPECKVVKCRFPVV--ENGKQ--ISGFGKKFYYKATVMFECDKGFYLDGSD 266

Query: 551 RLDCTRSGRWTDSPPMC----------EAIKCPELFAPEQGSLDCSD 587
            + C  +  W    P C               P    PE+G LD  D
Sbjct: 267 TIVCDSNSTWDPPVPKCLKGPRPTYKPPVSNYPGYPKPEEGILDSLD 313



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 13/49 (26%), Positives = 22/49 (44%)

Query: 220 FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIP 268
           F + +   F C  G+ ++G   + C ++  W    P+CL    P  K P
Sbjct: 246 FYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPP 294


>gi|27502405 CD46 antigen, complement regulatory protein isoform 14
           precursor [Homo sapiens]
          Length = 349

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 66/240 (27%), Positives = 92/240 (38%), Gaps = 30/240 (12%)

Query: 540 CDEGYSLSGP--ERLDCTRSGRWTD-SPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGS 596
           C +GY    P      C R+  W   S   C    CP +  P  G        G +  G 
Sbjct: 64  CKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQ--AVPANGTYEFGY 121

Query: 597 TCHFSCDNGFKLEGPNNVECTTSGR---WSATPPTCKGIASLPTPGVQCPALTTPGQGTM 653
             HF C+ G+ L G   + C   G    WS  PP C+ +   P P ++       G+ T 
Sbjct: 122 QMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK------NGKHTF 175

Query: 654 YCRHHPGTFGFNTTCYFGCNAG-----FTLIGDSTLSCRPSGQWTAVTPACRAVKCSELH 708
                   F +     + C+       F+LIG+ST+ C  +  W+   P C+ VKC    
Sbjct: 176 ---SEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC---- 228

Query: 709 VNKPIAMNCSNLWG---NFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGP 765
              P+  N   + G    F Y +   F C +G  L+GS    C  N  W   VP C  GP
Sbjct: 229 -RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGP 287



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 59/240 (24%), Positives = 90/240 (37%), Gaps = 18/240 (7%)

Query: 216 PLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQ---CLAAQCPPLKIPERGN 272
           P   +    +  + C  GY    P     +     T  P     C    CP ++ P  G 
Sbjct: 50  PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQ 109

Query: 273 MTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASG---VWTAPAPVCKAVQCQHLEA 329
               +    F +Q    F C EG+ L+G E++ C   G   +W+   P+C+ V C     
Sbjct: 110 AVPANGTYEFGYQMH--FICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167

Query: 330 PSEGTMDCVHPLTAFAYGSSCKFECQPG-----YRVRGLDMLRCIDSGHWSAPLPTCEAI 384
              G       +  F Y  +  + C P      + + G   + C D+  WS   P C+ +
Sbjct: 168 IKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 385 SCE-PLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC 443
            C  P+   V      S   + F Y     F C +GF L G+D + CD+   W  P P C
Sbjct: 227 KCRFPV---VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 70/287 (24%), Positives = 116/287 (40%), Gaps = 37/287 (12%)

Query: 328 EAPSEGTMDCV-HPLTAFAYGSSCKFECQPGY-RVRGLDMLRCIDSGHWSAPLP--TCEA 383
           E P+   M+ +  P   +  G    ++C+ GY  +  L      D  H   P+    C  
Sbjct: 37  EPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYR 96

Query: 384 ISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ---WTAPA 440
            +C  +  P++G     P+   +++     F C EG+ L G +I+ C+  G    W+   
Sbjct: 97  ETCPYIRDPLNGQ--AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154

Query: 441 PVCQALQCQDLPVPNEARVNCSHPFG---AFRYQSVCSFTCN-----EGLLLVGASVLQC 492
           P+C+ + C     P     N  H F     F Y    +++C+     +   L+G S + C
Sbjct: 155 PICEKVLC----TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC 210

Query: 493 LATGNWNSVPPECQAIPCT-PLLSPQNGTMTCVQPLGSSSY-KSTCQFICDEGYSLSGPE 550
                W+   PEC+ + C  P++  +NG    +   G   Y K+T  F CD+G+ L G +
Sbjct: 211 GDNSVWSRAAPECKVVKCRFPVV--ENGKQ--ISGFGKKFYYKATVMFECDKGFYLDGSD 266

Query: 551 RLDCTRSGRWTDSPPMC----------EAIKCPELFAPEQGSLDCSD 587
            + C  +  W    P C               P    PE+G LD  D
Sbjct: 267 TIVCDSNSTWDPPVPKCLKGPRPTYKPPVSNYPGYPKPEEGILDSLD 313



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 13/49 (26%), Positives = 22/49 (44%)

Query: 220 FSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIP 268
           F + +   F C  G+ ++G   + C ++  W    P+CL    P  K P
Sbjct: 246 FYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPP 294


>gi|27502427 CD46 antigen, complement regulatory protein isoform 12
           precursor [Homo sapiens]
          Length = 355

 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 76/297 (25%), Positives = 116/297 (39%), Gaps = 35/297 (11%)

Query: 540 CDEGYSLSGP--ERLDCTRSGRWTD-SPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGS 596
           C +GY    P      C R+  W   S   C    CP +  P  G        G +  G 
Sbjct: 64  CKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQ--AVPANGTYEFGY 121

Query: 597 TCHFSCDNGFKLEGPNNVECTTSGR---WSATPPTCKGIASLPTPGVQCPALTTPGQGTM 653
             HF C+ G+ L G   + C   G    WS  PP C+ +   P P ++       G+ T 
Sbjct: 122 QMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK------NGKHTF 175

Query: 654 YCRHHPGTFGFNTTCYFGCNAG-----FTLIGDSTLSCRPSGQWTAVTPACRAVKCSELH 708
                   F +     + C+       F+LIG+ST+ C  +  W+   P C+ VKC    
Sbjct: 176 ---SEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC---- 228

Query: 709 VNKPIAMNCSNLWG---NFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAG- 764
              P+  N   + G    F Y +   F C +G  L+GS    C  N  W   VP C  G 
Sbjct: 229 -RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGY 287

Query: 765 ---PLTIQEALTYFGGAVASTIGLIMGGTLLALLRKRFRQKDDGKCPLNPHSHLGTY 818
                 I ++L  +  AV   I +++G  ++ ++  R+ Q+   K   +  +   TY
Sbjct: 288 PKPEEGILDSLDVWVIAVI-VIAIVVGVAVICVVPYRYLQRRKKKGKADGGAEYATY 343



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 71/278 (25%), Positives = 121/278 (43%), Gaps = 33/278 (11%)

Query: 328 EAPSEGTMDCV-HPLTAFAYGSSCKFECQPGY-RVRGLDMLRCIDSGHWSAPLP--TCEA 383
           E P+   M+ +  P   +  G    ++C+ GY  +  L      D  H   P+    C  
Sbjct: 37  EPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYR 96

Query: 384 ISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ---WTAPA 440
            +C  +  P++G     P+   +++     F C EG+ L G +I+ C+  G    W+   
Sbjct: 97  ETCPYIRDPLNGQ--AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154

Query: 441 PVCQALQCQDLPVPNEARVNCSHPFG---AFRYQSVCSFTCN-----EGLLLVGASVLQC 492
           P+C+ + C     P     N  H F     F Y    +++C+     +   L+G S + C
Sbjct: 155 PICEKVLC----TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYC 210

Query: 493 LATGNWNSVPPECQAIPCT-PLLSPQNGTMTCVQPLGSSSY-KSTCQFICDEGYSLSGPE 550
                W+   PEC+ + C  P++  +NG    +   G   Y K+T  F CD+G+ L G +
Sbjct: 211 GDNSVWSRAAPECKVVKCRFPVV--ENGKQ--ISGFGKKFYYKATVMFECDKGFYLDGSD 266

Query: 551 RLDCTRSGRWTDSPPMCEAIK-CPELFAPEQGSLDCSD 587
            + C  +  W   PP+ + +K  P+   PE+G LD  D
Sbjct: 267 TIVCDSNSTW--DPPVPKCLKGYPK---PEEGILDSLD 299



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 59/240 (24%), Positives = 90/240 (37%), Gaps = 18/240 (7%)

Query: 216 PLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQ---CLAAQCPPLKIPERGN 272
           P   +    +  + C  GY    P     +     T  P     C    CP ++ P  G 
Sbjct: 50  PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQ 109

Query: 273 MTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASG---VWTAPAPVCKAVQCQHLEA 329
               +    F +Q    F C EG+ L+G E++ C   G   +W+   P+C+ V C     
Sbjct: 110 AVPANGTYEFGYQMH--FICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167

Query: 330 PSEGTMDCVHPLTAFAYGSSCKFECQPG-----YRVRGLDMLRCIDSGHWSAPLPTCEAI 384
              G       +  F Y  +  + C P      + + G   + C D+  WS   P C+ +
Sbjct: 168 IKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 385 SCE-PLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC 443
            C  P+   V      S   + F Y     F C +GF L G+D + CD+   W  P P C
Sbjct: 227 KCRFPV---VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283


>gi|166235138 seizure related 6 homolog (mouse)-like 2 isoform 3
           [Homo sapiens]
          Length = 840

 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 138/585 (23%), Positives = 212/585 (36%), Gaps = 109/585 (18%)

Query: 196 YVRECGELELPQH--VLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECL--ASGIWT 251
           Y+  CG    P H  V +   HP G        +FHC  GYQ+ G   L CL      W 
Sbjct: 216 YLLSCGFPPRPAHGDVSVTDLHPGGT------ATFHCDSGYQLQGEETLICLNGTRPSWN 269

Query: 252 NKPPQCLA--------AQCPPLKIPERG-----NMTC-------------LHSAKAFQHQ 285
            + P C+A        A    +  PE G     N+TC             LH  +    +
Sbjct: 270 GETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDE 329

Query: 286 SSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMD--------- 336
            +       G + + P +       V      +    Q  ++E  SE   +         
Sbjct: 330 DNDRLMVRSGGSPLSPVIYDSDMDDV--PERGLISDAQSLYVELLSETPANPLLLSLRFE 387

Query: 337 ------CVHPLTA----------FAYGSSCKFECQPGYRVRGL---DMLRCID--SGHWS 375
                 C  P  A          +  G+   F C PGY +      + + C+D    HW+
Sbjct: 388 AFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWN 447

Query: 376 APLPTCEAISCEPLESPVHGSMDCSPSL-RAFQYDTNCSFRC---AEGFMLRGADIVRC- 430
              P C+A+    L  P    +  SP   +++    +C +      E  +L   +I+   
Sbjct: 448 DTEPACKAMCGGELSEPA--GVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR 505

Query: 431 --DNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGAS 488
             D L  +    P  + L     P P   R+  S P    ++Q+      N GL   G  
Sbjct: 506 EGDMLTLFDGDGPSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPG-PPNPGL---GQG 560

Query: 489 VLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSG 548
            +      ++  VP   +   C  L  P+ G  T     G     +   + C+ GY L G
Sbjct: 561 FVL-----HFKEVP---RNDTCPELPPPEWGWRTASH--GDLIRGTVLTYQCEPGYELLG 610

Query: 549 PERLDCTRSGRWTDSPPMCEAI-KCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFK 607
            + L C     W+ +PP C+ I  C +      G    SD    F VGS   + C  G+ 
Sbjct: 611 SDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD--AGFPVGSHVQYRCLPGYS 668

Query: 608 LEGPNNVEC----TTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFG 663
           LEG   + C    T + +WS   P C    +L       P +   G  T+Y +HH   + 
Sbjct: 669 LEGAAMLTCYSRDTGTPKWSDRVPKC----ALKYEPCLNPGVPENGYQTLY-KHH---YQ 720

Query: 664 FNTTCYFGCNAGFTLIGDSTLSCRPS--GQWTAVTPACRAVKCSE 706
              +  F C  GF LIG+ T++C P    QWT+  P C+  + ++
Sbjct: 721 AGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTD 765



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 60/219 (27%), Positives = 88/219 (40%), Gaps = 22/219 (10%)

Query: 324 CQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEA 383
           C  L  P  G     H       G+   ++C+PGY + G D+L C     WSA  P C+ 
Sbjct: 574 CPELPPPEWGWRTASHG--DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQK 631

Query: 384 I-SCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRC----DNLGQWTA 438
           I +C       +G    S +   F   ++  +RC  G+ L GA ++ C        +W+ 
Sbjct: 632 IMTCADPGEIANGHRTASDA--GFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSD 689

Query: 439 PAPVCQALQ---CQDLPVP-NEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLA 494
             P C AL+   C +  VP N  +    H + A        F C EG  L+G   + C+ 
Sbjct: 690 RVPKC-ALKYEPCLNPGVPENGYQTLYKHHYQA---GESLRFFCYEGFELIGEVTITCVP 745

Query: 495 --TGNWNSVPPECQAIPCTP---LLSPQNGTMTCVQPLG 528
                W S PP C+    T     L   N  +  + PLG
Sbjct: 746 GHPSQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLPLG 784



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 59/224 (26%), Positives = 88/224 (39%), Gaps = 20/224 (8%)

Query: 572 CPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKG 631
           CPEL  PE G    S   G+   G+   + C+ G++L G + + C     WSA PP C+ 
Sbjct: 574 CPELPPPEWGWRTAS--HGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQK 631

Query: 632 IASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSC--RPS 689
           I +   PG       T              F   +   + C  G++L G + L+C  R +
Sbjct: 632 IMTCADPGEIANGHRTASD---------AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDT 682

Query: 690 G--QWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTA 747
           G  +W+   P C       L+   P     +    ++  G    F C EG  L G     
Sbjct: 683 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTIT 742

Query: 748 CQENGH---WSTTVPTCQAGPLTIQEALTYFGGAVASTIGLIMG 788
           C   GH   W++  P C+    T   +    GG +A  I L +G
Sbjct: 743 CVP-GHPSQWTSQPPLCKV-TQTTDPSRQLEGGNLALAILLPLG 784



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 41/153 (26%), Positives = 60/153 (39%), Gaps = 18/153 (11%)

Query: 192 PECEYVREC---GELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASG 248
           P C+ +  C   GE+        +   P+G     S   + C  GY + G + L C +  
Sbjct: 627 PACQKIMTCADPGEIANGHRTASDAGFPVG-----SHVQYRCLPGYSLEGAAMLTCYSRD 681

Query: 249 I----WTNKPPQCLAAQCPPLK--IPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPE 302
                W+++ P+C     P L   +PE G  T       +Q   S  F C EGF L+G  
Sbjct: 682 TGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHH--YQAGESLRFFCYEGFELIGEV 739

Query: 303 VVQCTAS--GVWTAPAPVCKAVQCQHLEAPSEG 333
            + C       WT+  P+CK  Q        EG
Sbjct: 740 TITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEG 772



 Score = 34.3 bits (77), Expect = 0.49
 Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 11/55 (20%)

Query: 658 HPGTFGFNTTCYFGCNAGFTLIGDSTLSC----RPSGQWTAVTPACRAVKCSELH 708
           HPG      T  F C++G+ L G+ TL C    RPS  W   TP+C A     +H
Sbjct: 237 HPGG-----TATFHCDSGYQLQGEETLICLNGTRPS--WNGETPSCMASCGGTIH 284


>gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2
           [Homo sapiens]
          Length = 910

 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 138/585 (23%), Positives = 212/585 (36%), Gaps = 109/585 (18%)

Query: 196 YVRECGELELPQH--VLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECL--ASGIWT 251
           Y+  CG    P H  V +   HP G        +FHC  GYQ+ G   L CL      W 
Sbjct: 286 YLLSCGFPPRPAHGDVSVTDLHPGGT------ATFHCDSGYQLQGEETLICLNGTRPSWN 339

Query: 252 NKPPQCLA--------AQCPPLKIPERG-----NMTC-------------LHSAKAFQHQ 285
            + P C+A        A    +  PE G     N+TC             LH  +    +
Sbjct: 340 GETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDE 399

Query: 286 SSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMD--------- 336
            +       G + + P +       V      +    Q  ++E  SE   +         
Sbjct: 400 DNDRLMVRSGGSPLSPVIYDSDMDDV--PERGLISDAQSLYVELLSETPANPLLLSLRFE 457

Query: 337 ------CVHPLTA----------FAYGSSCKFECQPGYRVRGL---DMLRCID--SGHWS 375
                 C  P  A          +  G+   F C PGY +      + + C+D    HW+
Sbjct: 458 AFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWN 517

Query: 376 APLPTCEAISCEPLESPVHGSMDCSPSL-RAFQYDTNCSFRC---AEGFMLRGADIVRC- 430
              P C+A+    L  P    +  SP   +++    +C +      E  +L   +I+   
Sbjct: 518 DTEPACKAMCGGELSEPA--GVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVR 575

Query: 431 --DNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGAS 488
             D L  +    P  + L     P P   R+  S P    ++Q+      N GL   G  
Sbjct: 576 EGDMLTLFDGDGPSARVLAQLRGPQPRR-RLLSSGPDLTLQFQAPPG-PPNPGL---GQG 630

Query: 489 VLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSG 548
            +      ++  VP   +   C  L  P+ G  T     G     +   + C+ GY L G
Sbjct: 631 FVL-----HFKEVP---RNDTCPELPPPEWGWRTASH--GDLIRGTVLTYQCEPGYELLG 680

Query: 549 PERLDCTRSGRWTDSPPMCEAI-KCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFK 607
            + L C     W+ +PP C+ I  C +      G    SD    F VGS   + C  G+ 
Sbjct: 681 SDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASD--AGFPVGSHVQYRCLPGYS 738

Query: 608 LEGPNNVEC----TTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFG 663
           LEG   + C    T + +WS   P C    +L       P +   G  T+Y +HH   + 
Sbjct: 739 LEGAAMLTCYSRDTGTPKWSDRVPKC----ALKYEPCLNPGVPENGYQTLY-KHH---YQ 790

Query: 664 FNTTCYFGCNAGFTLIGDSTLSCRPS--GQWTAVTPACRAVKCSE 706
              +  F C  GF LIG+ T++C P    QWT+  P C+  + ++
Sbjct: 791 AGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTD 835



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 60/219 (27%), Positives = 88/219 (40%), Gaps = 22/219 (10%)

Query: 324 CQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEA 383
           C  L  P  G     H       G+   ++C+PGY + G D+L C     WSA  P C+ 
Sbjct: 644 CPELPPPEWGWRTASHG--DLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQK 701

Query: 384 I-SCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRC----DNLGQWTA 438
           I +C       +G    S +   F   ++  +RC  G+ L GA ++ C        +W+ 
Sbjct: 702 IMTCADPGEIANGHRTASDA--GFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSD 759

Query: 439 PAPVCQALQ---CQDLPVP-NEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLA 494
             P C AL+   C +  VP N  +    H + A        F C EG  L+G   + C+ 
Sbjct: 760 RVPKC-ALKYEPCLNPGVPENGYQTLYKHHYQA---GESLRFFCYEGFELIGEVTITCVP 815

Query: 495 --TGNWNSVPPECQAIPCTP---LLSPQNGTMTCVQPLG 528
                W S PP C+    T     L   N  +  + PLG
Sbjct: 816 GHPSQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLPLG 854



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 59/224 (26%), Positives = 88/224 (39%), Gaps = 20/224 (8%)

Query: 572 CPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKG 631
           CPEL  PE G    S   G+   G+   + C+ G++L G + + C     WSA PP C+ 
Sbjct: 644 CPELPPPEWGWRTAS--HGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQK 701

Query: 632 IASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSC--RPS 689
           I +   PG       T              F   +   + C  G++L G + L+C  R +
Sbjct: 702 IMTCADPGEIANGHRTASD---------AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDT 752

Query: 690 G--QWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTA 747
           G  +W+   P C       L+   P     +    ++  G    F C EG  L G     
Sbjct: 753 GTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTIT 812

Query: 748 CQENGH---WSTTVPTCQAGPLTIQEALTYFGGAVASTIGLIMG 788
           C   GH   W++  P C+    T   +    GG +A  I L +G
Sbjct: 813 CVP-GHPSQWTSQPPLCKV-TQTTDPSRQLEGGNLALAILLPLG 854



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 41/153 (26%), Positives = 60/153 (39%), Gaps = 18/153 (11%)

Query: 192 PECEYVREC---GELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASG 248
           P C+ +  C   GE+        +   P+G     S   + C  GY + G + L C +  
Sbjct: 697 PACQKIMTCADPGEIANGHRTASDAGFPVG-----SHVQYRCLPGYSLEGAAMLTCYSRD 751

Query: 249 I----WTNKPPQCLAAQCPPLK--IPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPE 302
                W+++ P+C     P L   +PE G  T       +Q   S  F C EGF L+G  
Sbjct: 752 TGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHH--YQAGESLRFFCYEGFELIGEV 809

Query: 303 VVQCTAS--GVWTAPAPVCKAVQCQHLEAPSEG 333
            + C       WT+  P+CK  Q        EG
Sbjct: 810 TITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEG 842



 Score = 34.3 bits (77), Expect = 0.49
 Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 11/55 (20%)

Query: 658 HPGTFGFNTTCYFGCNAGFTLIGDSTLSC----RPSGQWTAVTPACRAVKCSELH 708
           HPG      T  F C++G+ L G+ TL C    RPS  W   TP+C A     +H
Sbjct: 307 HPGG-----TATFHCDSGYQLQGEETLICLNGTRPS--WNGETPSCMASCGGTIH 354


>gi|27502421 CD46 antigen, complement regulatory protein isoform 13
           precursor [Homo sapiens]
          Length = 373

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 50/176 (28%), Positives = 80/176 (45%), Gaps = 11/176 (6%)

Query: 218 GNFSFNSQCSFHCTDGYQVNGPSKLECLASG---IWTNKPPQCLAAQCPPLKIPERGNMT 274
           G + F  Q  F C +GY + G   L C   G   IW+ KPP C    C P    + G  T
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT 174

Query: 275 CLHSAKAFQHQSSCSFSCE-----EGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEA 329
                + F++  + ++SC+     + F+L+G   + C  + VW+  AP CK V+C+    
Sbjct: 175 -FSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVV 233

Query: 330 PSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAIS 385
            +   +        F Y ++  FEC  G+ + G D + C  +  W  P+P C  +S
Sbjct: 234 ENGKQISGFGK--KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 59/240 (24%), Positives = 90/240 (37%), Gaps = 18/240 (7%)

Query: 216 PLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQ---CLAAQCPPLKIPERGN 272
           P   +    +  + C  GY    P     +     T  P     C    CP ++ P  G 
Sbjct: 50  PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQ 109

Query: 273 MTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASG---VWTAPAPVCKAVQCQHLEA 329
               +    F +Q    F C EG+ L+G E++ C   G   +W+   P+C+ V C     
Sbjct: 110 AVPANGTYEFGYQMH--FICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167

Query: 330 PSEGTMDCVHPLTAFAYGSSCKFECQPG-----YRVRGLDMLRCIDSGHWSAPLPTCEAI 384
              G       +  F Y  +  + C P      + + G   + C D+  WS   P C+ +
Sbjct: 168 IKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 385 SCE-PLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC 443
            C  P+   V      S   + F Y     F C +GF L G+D + CD+   W  P P C
Sbjct: 227 KCRFPV---VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 64/260 (24%), Positives = 106/260 (40%), Gaps = 18/260 (6%)

Query: 406 FQYDTNCSFRCAEGFMLRG--ADIVRCDNLGQWTAPAP-VCQALQCQDLPVPNEARVNCS 462
           ++      ++C +G+      A    CD    W   +   C    C  +  P   +   +
Sbjct: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 463 HPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGN---WNSVPPECQAIPCTPLLSPQNG 519
           +    F YQ    F CNEG  L+G  +L C   G+   W+  PP C+ + CTP    +NG
Sbjct: 114 NGTYEFGYQM--HFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNG 171

Query: 520 TMTCVQPLGSSSYKSTCQFICD-----EGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPE 574
             T  + +    Y     + CD     + +SL G   + C  +  W+ + P C+ +KC  
Sbjct: 172 KHTFSE-VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR- 229

Query: 575 LFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIAS 634
            F   +     S    +F   +T  F CD GF L+G + + C ++  W    P C  +++
Sbjct: 230 -FPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVST 288

Query: 635 LPTPGVQCPALTTPGQGTMY 654
             T   + PA +  G    Y
Sbjct: 289 SST--TKSPASSASGPRPTY 306



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 64/236 (27%), Positives = 90/236 (38%), Gaps = 30/236 (12%)

Query: 540 CDEGYSLSGP--ERLDCTRSGRWTD-SPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGS 596
           C +GY    P      C R+  W   S   C    CP +  P  G        G +  G 
Sbjct: 64  CKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQ--AVPANGTYEFGY 121

Query: 597 TCHFSCDNGFKLEGPNNVECTTSGR---WSATPPTCKGIASLPTPGVQCPALTTPGQGTM 653
             HF C+ G+ L G   + C   G    WS  PP C+ +   P P ++       G+ T 
Sbjct: 122 QMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK------NGKHTF 175

Query: 654 YCRHHPGTFGFNTTCYFGCNAG-----FTLIGDSTLSCRPSGQWTAVTPACRAVKCSELH 708
                   F +     + C+       F+LIG+ST+ C  +  W+   P C+ VKC    
Sbjct: 176 ---SEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC---- 228

Query: 709 VNKPIAMNCSNLWG---NFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
              P+  N   + G    F Y +   F C +G  L+GS    C  N  W   VP C
Sbjct: 229 -RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 61/241 (25%), Positives = 90/241 (37%), Gaps = 24/241 (9%)

Query: 476 FTCNEGLLLVGASVLQCLATGNWNSVPPE---CQAIPCTPLLSPQNGTMTCVQPLGSSSY 532
           + C +G   +       +   N   +P     C    C  +  P NG    V   G+  +
Sbjct: 62  YKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQ--AVPANGTYEF 119

Query: 533 KSTCQFICDEGYSLSGPERLDCTRSGR---WTDSPPMCEAIKCPELFAPEQGSLDCSDTR 589
                FIC+EGY L G E L C   G    W+  PP+CE + C      + G    S+  
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVE 179

Query: 590 GEFNVGSTCHFSCD-----NGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPA 644
             F       +SCD     + F L G + + C  +  WS   P CK +        + P 
Sbjct: 180 -VFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC------RFPV 232

Query: 645 LTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKC 704
           +    Q + + +     F +  T  F C+ GF L G  T+ C  +  W    P C  V  
Sbjct: 233 VENGKQISGFGKK----FYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVST 288

Query: 705 S 705
           S
Sbjct: 289 S 289



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 42/195 (21%), Positives = 72/195 (36%), Gaps = 32/195 (16%)

Query: 158 CYTASCQDMSCSKQGECLETIGNYTCS------CYPGFY--GPECEYVRECGELEL---- 205
           CY  +C  +     G+ +   G Y         C  G+Y  G E  Y    G + +    
Sbjct: 94  CYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153

Query: 206 ----------PQHVLMNCSHPLGN---FSFNSQCSFHCT-----DGYQVNGPSKLECLAS 247
                     P   + N  H       F +    ++ C      D + + G S + C  +
Sbjct: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDN 213

Query: 248 GIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCT 307
            +W+   P+C   +C    + E G        K F ++++  F C++GF L G + + C 
Sbjct: 214 SVWSRAAPECKVVKCR-FPVVENGKQIS-GFGKKFYYKATVMFECDKGFYLDGSDTIVCD 271

Query: 308 ASGVWTAPAPVCKAV 322
           ++  W  P P C  V
Sbjct: 272 SNSTWDPPVPKCLKV 286



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 35/132 (26%), Positives = 50/132 (37%), Gaps = 17/132 (12%)

Query: 642 CPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQ---WTAVTPA 698
           CP +  P  G     +  GT+ F    +F CN G+ LIG+  L C   G    W+   P 
Sbjct: 99  CPYIRDPLNGQAVPAN--GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156

Query: 699 CRAVKCSELHVNKPIAMNCSNLWGN---FSYGSICSFHCLEGQ-----LLNGSAQTACQE 750
           C  V C+      P   N  + +     F Y    ++ C          L G +   C +
Sbjct: 157 CEKVLCTP----PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD 212

Query: 751 NGHWSTTVPTCQ 762
           N  WS   P C+
Sbjct: 213 NSVWSRAAPECK 224


>gi|27502417 CD46 antigen, complement regulatory protein isoform 10
           precursor [Homo sapiens]
          Length = 370

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 50/176 (28%), Positives = 80/176 (45%), Gaps = 11/176 (6%)

Query: 218 GNFSFNSQCSFHCTDGYQVNGPSKLECLASG---IWTNKPPQCLAAQCPPLKIPERGNMT 274
           G + F  Q  F C +GY + G   L C   G   IW+ KPP C    C P    + G  T
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHT 174

Query: 275 CLHSAKAFQHQSSCSFSCE-----EGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEA 329
                + F++  + ++SC+     + F+L+G   + C  + VW+  AP CK V+C+    
Sbjct: 175 -FSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVV 233

Query: 330 PSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAIS 385
            +   +        F Y ++  FEC  G+ + G D + C  +  W  P+P C  +S
Sbjct: 234 ENGKQISGFGK--KFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVS 287



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 59/240 (24%), Positives = 90/240 (37%), Gaps = 18/240 (7%)

Query: 216 PLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQ---CLAAQCPPLKIPERGN 272
           P   +    +  + C  GY    P     +     T  P     C    CP ++ P  G 
Sbjct: 50  PKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQ 109

Query: 273 MTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASG---VWTAPAPVCKAVQCQHLEA 329
               +    F +Q    F C EG+ L+G E++ C   G   +W+   P+C+ V C     
Sbjct: 110 AVPANGTYEFGYQMH--FICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167

Query: 330 PSEGTMDCVHPLTAFAYGSSCKFECQPG-----YRVRGLDMLRCIDSGHWSAPLPTCEAI 384
              G       +  F Y  +  + C P      + + G   + C D+  WS   P C+ +
Sbjct: 168 IKNGK-HTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVV 226

Query: 385 SCE-PLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC 443
            C  P+   V      S   + F Y     F C +GF L G+D + CD+   W  P P C
Sbjct: 227 KCRFPV---VENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 63/255 (24%), Positives = 105/255 (41%), Gaps = 18/255 (7%)

Query: 406 FQYDTNCSFRCAEGFMLRG--ADIVRCDNLGQWTAPAP-VCQALQCQDLPVPNEARVNCS 462
           ++      ++C +G+      A    CD    W   +   C    C  +  P   +   +
Sbjct: 54  YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113

Query: 463 HPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGN---WNSVPPECQAIPCTPLLSPQNG 519
           +    F YQ    F CNEG  L+G  +L C   G+   W+  PP C+ + CTP    +NG
Sbjct: 114 NGTYEFGYQM--HFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNG 171

Query: 520 TMTCVQPLGSSSYKSTCQFICD-----EGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPE 574
             T  + +    Y     + CD     + +SL G   + C  +  W+ + P C+ +KC  
Sbjct: 172 KHTFSE-VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR- 229

Query: 575 LFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIAS 634
            F   +     S    +F   +T  F CD GF L+G + + C ++  W    P C  +++
Sbjct: 230 -FPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVST 288

Query: 635 LPTPGVQCPALTTPG 649
             T   + PA +  G
Sbjct: 289 SST--TKSPASSASG 301



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 64/236 (27%), Positives = 90/236 (38%), Gaps = 30/236 (12%)

Query: 540 CDEGYSLSGP--ERLDCTRSGRWTD-SPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGS 596
           C +GY    P      C R+  W   S   C    CP +  P  G        G +  G 
Sbjct: 64  CKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQ--AVPANGTYEFGY 121

Query: 597 TCHFSCDNGFKLEGPNNVECTTSGR---WSATPPTCKGIASLPTPGVQCPALTTPGQGTM 653
             HF C+ G+ L G   + C   G    WS  PP C+ +   P P ++       G+ T 
Sbjct: 122 QMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK------NGKHTF 175

Query: 654 YCRHHPGTFGFNTTCYFGCNAG-----FTLIGDSTLSCRPSGQWTAVTPACRAVKCSELH 708
                   F +     + C+       F+LIG+ST+ C  +  W+   P C+ VKC    
Sbjct: 176 ---SEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC---- 228

Query: 709 VNKPIAMNCSNLWG---NFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
              P+  N   + G    F Y +   F C +G  L+GS    C  N  W   VP C
Sbjct: 229 -RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 61/241 (25%), Positives = 90/241 (37%), Gaps = 24/241 (9%)

Query: 476 FTCNEGLLLVGASVLQCLATGNWNSVPPE---CQAIPCTPLLSPQNGTMTCVQPLGSSSY 532
           + C +G   +       +   N   +P     C    C  +  P NG    V   G+  +
Sbjct: 62  YKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQ--AVPANGTYEF 119

Query: 533 KSTCQFICDEGYSLSGPERLDCTRSGR---WTDSPPMCEAIKCPELFAPEQGSLDCSDTR 589
                FIC+EGY L G E L C   G    W+  PP+CE + C      + G    S+  
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVE 179

Query: 590 GEFNVGSTCHFSCD-----NGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPA 644
             F       +SCD     + F L G + + C  +  WS   P CK +        + P 
Sbjct: 180 -VFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC------RFPV 232

Query: 645 LTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKC 704
           +    Q + + +     F +  T  F C+ GF L G  T+ C  +  W    P C  V  
Sbjct: 233 VENGKQISGFGKK----FYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVST 288

Query: 705 S 705
           S
Sbjct: 289 S 289



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 42/195 (21%), Positives = 72/195 (36%), Gaps = 32/195 (16%)

Query: 158 CYTASCQDMSCSKQGECLETIGNYTCS------CYPGFY--GPECEYVRECGELEL---- 205
           CY  +C  +     G+ +   G Y         C  G+Y  G E  Y    G + +    
Sbjct: 94  CYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153

Query: 206 ----------PQHVLMNCSHPLGN---FSFNSQCSFHCT-----DGYQVNGPSKLECLAS 247
                     P   + N  H       F +    ++ C      D + + G S + C  +
Sbjct: 154 PPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDN 213

Query: 248 GIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCT 307
            +W+   P+C   +C    + E G        K F ++++  F C++GF L G + + C 
Sbjct: 214 SVWSRAAPECKVVKCR-FPVVENGKQIS-GFGKKFYYKATVMFECDKGFYLDGSDTIVCD 271

Query: 308 ASGVWTAPAPVCKAV 322
           ++  W  P P C  V
Sbjct: 272 SNSTWDPPVPKCLKV 286



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 35/132 (26%), Positives = 50/132 (37%), Gaps = 17/132 (12%)

Query: 642 CPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQ---WTAVTPA 698
           CP +  P  G     +  GT+ F    +F CN G+ LIG+  L C   G    W+   P 
Sbjct: 99  CPYIRDPLNGQAVPAN--GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPI 156

Query: 699 CRAVKCSELHVNKPIAMNCSNLWGN---FSYGSICSFHCLEGQ-----LLNGSAQTACQE 750
           C  V C+      P   N  + +     F Y    ++ C          L G +   C +
Sbjct: 157 CEKVLCTP----PPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGD 212

Query: 751 NGHWSTTVPTCQ 762
           N  WS   P C+
Sbjct: 213 NSVWSRAAPECK 224


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.134    0.456 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,176,648
Number of Sequences: 37866
Number of extensions: 2168014
Number of successful extensions: 10125
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 204
Number of HSP's successfully gapped in prelim test: 205
Number of HSP's that attempted gapping in prelim test: 4511
Number of HSP's gapped (non-prelim): 2544
length of query: 830
length of database: 18,247,518
effective HSP length: 111
effective length of query: 719
effective length of database: 14,044,392
effective search space: 10097917848
effective search space used: 10097917848
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.