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Search of human proteins with 157388925
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157388925 solute carrier family 25, member 38 [Homo sapiens]
(304 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157388925 solute carrier family 25, member 38 [Homo sapiens] 609 e-174
gi|116235462 solute carrier family 25, member 45 isoform a [Homo... 101 7e-22
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit... 100 2e-21
gi|13449279 solute carrier family 25 (mitochondrial oxodicarboxy... 98 8e-21
gi|149274643 solute carrier family 25, member 28 [Homo sapiens] 96 3e-20
gi|219555665 solute carrier family 25, member 39 isoform a [Homo... 96 4e-20
gi|46094065 mitochondrial carrier family protein [Homo sapiens] 96 5e-20
gi|27544933 solute carrier family 25, member 16 [Homo sapiens] 95 9e-20
gi|7706306 solute carrier family 25, member 39 isoform b [Homo s... 94 1e-19
gi|13259541 uncoupling protein 2 [Homo sapiens] 90 2e-18
gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens] 90 3e-18
gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho... 89 4e-18
gi|13259543 solute carrier family 25, member 14 isoform UCP5S [H... 89 4e-18
gi|58197562 solute carrier family 25, member 30 [Homo sapiens] 88 1e-17
gi|86198310 solute carrier family 25, member 29 [Homo sapiens] 88 1e-17
gi|82775373 solute carrier family 25, member 37 [Homo sapiens] 87 2e-17
gi|11225256 uncoupling protein 1 [Homo sapiens] 86 3e-17
gi|186928856 solute carrier family 25, member 19 [Homo sapiens] 86 3e-17
gi|186928860 solute carrier family 25, member 19 [Homo sapiens] 86 3e-17
gi|186928858 solute carrier family 25, member 19 [Homo sapiens] 86 3e-17
gi|21314739 solute carrier family 25, member 32 [Homo sapiens] 86 4e-17
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ... 86 4e-17
gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s... 86 4e-17
gi|116235466 solute carrier family 25, member 45 isoform b [Homo... 84 1e-16
gi|48476342 solute carrier family 25, member 23 [Homo sapiens] 84 1e-16
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo... 83 3e-16
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s... 83 3e-16
gi|21361103 solute carrier family 25, member 12 [Homo sapiens] 82 4e-16
gi|20149598 solute carrier family 25 (mitochondrial carrier; dic... 82 8e-16
gi|14150082 mitochondrial carrier protein MGC4399 [Homo sapiens] 79 6e-15
>gi|157388925 solute carrier family 25, member 38 [Homo sapiens]
Length = 304
Score = 609 bits (1570), Expect = e-174
Identities = 304/304 (100%), Positives = 304/304 (100%)
Query: 1 MIQNSRPSLLQPQDVGDTVETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQP 60
MIQNSRPSLLQPQDVGDTVETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQP
Sbjct: 1 MIQNSRPSLLQPQDVGDTVETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQP 60
Query: 61 SDHGSRRVGMLAVLLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHP 120
SDHGSRRVGMLAVLLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHP
Sbjct: 61 SDHGSRRVGMLAVLLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHP 120
Query: 121 PTALESVMLGVGSRSVAGVCMSPITVIKTRYESGKYGYESIYAALRSIYHSEGHRGLFSG 180
PTALESVMLGVGSRSVAGVCMSPITVIKTRYESGKYGYESIYAALRSIYHSEGHRGLFSG
Sbjct: 121 PTALESVMLGVGSRSVAGVCMSPITVIKTRYESGKYGYESIYAALRSIYHSEGHRGLFSG 180
Query: 181 LTATLLRDAPFSGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADV 240
LTATLLRDAPFSGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADV
Sbjct: 181 LTATLLRDAPFSGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADV 240
Query: 241 IKTHMQLYPLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEMMAKM 300
IKTHMQLYPLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEMMAKM
Sbjct: 241 IKTHMQLYPLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEMMAKM 300
Query: 301 GLKS 304
GLKS
Sbjct: 301 GLKS 304
>gi|116235462 solute carrier family 25, member 45 isoform a [Homo
sapiens]
Length = 288
Score = 101 bits (252), Expect = 7e-22
Identities = 88/295 (29%), Positives = 133/295 (45%), Gaps = 30/295 (10%)
Query: 28 IKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGLW 87
++ F+ G ISG +L P D +K RLQT + G++ ++K+ R ESLLG +
Sbjct: 3 VEEFVAGWISGALGLVLGHPFDTVKVRLQTQ------TTYRGIVDCMVKIYRHESLLGFF 56
Query: 88 KGMSPSI--VRCVPGV--GIYFGTLYSL---KQYFLRGHPPTALESVMLGVGSRSVAGVC 140
KGMS I + V V G+Y TL L R PP+ + + G + C
Sbjct: 57 KGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYC 116
Query: 141 MSPITVIKTRYE----------SGKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAP 190
++P +IK R + S Y+ SI+ EG RGLF G A LRD P
Sbjct: 117 LAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTP 176
Query: 191 FSGIYLMFY-NQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQLYP 249
GIY + Y + P Q ++ T G FAGI + + P D+IK+ MQ+
Sbjct: 177 TVGIYFITYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVAATPLDMIKSRMQMDG 233
Query: 250 LK---FQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEMMAKMG 301
L+ +Q + + + GL FF+G + R + A+ + YE ++ G
Sbjct: 234 LRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRWWG 288
Score = 31.6 bits (70), Expect = 0.91
Identities = 16/59 (27%), Positives = 29/59 (49%), Gaps = 1/59 (1%)
Query: 216 IPITNFSCGIFAGILASLVTQPADVIKTHMQLYPLKFQWIGQAVTLIFKDYGLRGFFQG 274
+P+ F G +G L ++ P D +K +Q ++ I + I++ L GFF+G
Sbjct: 1 MPVEEFVAGWISGALGLVLGHPFDTVKVRLQT-QTTYRGIVDCMVKIYRHESLLGFFKG 58
>gi|21389315 solute carrier family 25 (mitochondrial carrier;
citrate transporter), member 1 precursor [Homo sapiens]
Length = 311
Score = 100 bits (248), Expect = 2e-21
Identities = 76/282 (26%), Positives = 129/282 (45%), Gaps = 9/282 (3%)
Query: 23 MLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTES 82
+ HP KA L G ++G + P + +KT+LQ L H R G+ + + VR+
Sbjct: 22 LTHPG-KAILAGGLAGGIEICITFPTEYVKTQLQ-LDERSHPPRYRGIGDCVRQTVRSHG 79
Query: 83 LLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPT-ALESVMLGVGSR-SVAGVC 140
+LGL++G+S + +P + FG L + + ++ G+G+ + A V
Sbjct: 80 VLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVV 139
Query: 141 MSPITVIKTRY----ESGKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYL 196
+ P+ IK ++ S Y + +R I +G +G + GLTAT+L+ I
Sbjct: 140 VCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRF 199
Query: 197 MFYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQ-LYPLKFQWI 255
+N D + + P+ G AG + P DVIKT MQ L K++
Sbjct: 200 FVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNT 259
Query: 256 GQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEMM 297
I K GL+ F++G +PR R L A+ + +Y+E++
Sbjct: 260 WDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVV 301
>gi|13449279 solute carrier family 25 (mitochondrial
oxodicarboxylate carrier), member 21 [Homo sapiens]
Length = 299
Score = 98.2 bits (243), Expect = 8e-21
Identities = 72/285 (25%), Positives = 131/285 (45%), Gaps = 11/285 (3%)
Query: 20 ETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVR 79
E ++ + + G +G L PLD++KTR Q + + + ++ + +
Sbjct: 6 EVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQ 65
Query: 80 TESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESVMLGVGSRSVAGV 139
E L G +KG+ P I+ P + F T K+ AL + G+GS +
Sbjct: 66 MEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLGSGLTEAI 125
Query: 140 CMSPITVIKTRYESGKYGYE---SIYAALRSIYHSEGH--RGLFSGLTATLLRDAPFSGI 194
++P V+K ++ + + S R I EG +GL GLTATL R F+ +
Sbjct: 126 VVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMV 185
Query: 195 YLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQ-----LYP 249
Y FY KN++P ++ D L F G+ +G +AS++ P DV K+ +Q
Sbjct: 186 YFGFYYNVKNMIPVNK-DPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPGE 244
Query: 250 LKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYE 294
+K++ + + ++++ G+ ++G +P+ +R A+ VYE
Sbjct: 245 IKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYE 289
Score = 57.0 bits (136), Expect = 2e-08
Identities = 49/194 (25%), Positives = 83/194 (42%), Gaps = 23/194 (11%)
Query: 24 LHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTL------QPSDHGSRRVGMLAVLLKV 77
L P + + G SG ++ P +++K LQ QPS G R ++
Sbjct: 106 LSPALTFAIAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYAR--------QI 157
Query: 78 VRTES--LLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESVMLGVG--S 133
++ E L GL KG++ ++ R +YFG Y++K P G+G S
Sbjct: 158 IKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLS 217
Query: 134 RSVAGVCMSPITVIKTRYES-----GKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRD 188
++A V P V K+R + G+ Y + + + ++Y EG L+ GL ++R
Sbjct: 218 GTIASVINIPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRL 277
Query: 189 APFSGIYLMFYNQT 202
P + L+ Y T
Sbjct: 278 GPGGAVMLLVYEYT 291
Score = 39.3 bits (90), Expect = 0.004
Identities = 23/83 (27%), Positives = 42/83 (50%), Gaps = 5/83 (6%)
Query: 227 AGILASLVTQPADVIKTHMQLY-----PLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALR 281
AG++ + P DV+KT Q+ P ++ + + +IF+ GL GF++G +P L
Sbjct: 23 AGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKGILPPILA 82
Query: 282 RTLMAAMAWTVYEEMMAKMGLKS 304
T A+ + +E+ +G S
Sbjct: 83 ETPKRAVKFFTFEQYKKLLGYVS 105
>gi|149274643 solute carrier family 25, member 28 [Homo sapiens]
Length = 364
Score = 96.3 bits (238), Expect = 3e-20
Identities = 73/302 (24%), Positives = 128/302 (42%), Gaps = 17/302 (5%)
Query: 6 RPSLLQPQDVGDTVETLMLHPVIKAFL-CGSISGTCSTLLFQPLDLLKTRLQTLQPSDHG 64
RP + Q D G E L + + G+++G + P+D +KTR+Q+LQP D
Sbjct: 50 RPPVRQDPDSGPDYEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQP-DPA 108
Query: 65 SRRVGMLAVLLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTAL 124
+R +L L +++RTE L +G++ + P +YF LK+ P
Sbjct: 109 ARYRNVLEALWRIIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGN 168
Query: 125 ESVMLGVG---SRSVAGVCMSPITVIKTRYESGKYGYESIYAALRSIYHSEGHRGLFSGL 181
+ G + + M+P V+K R + Y + +R+++ +EG +
Sbjct: 169 SHIANGAAGCVATLLHDAAMNPAEVVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSY 228
Query: 182 TATLLRDAPFSGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVI 241
T L + PF I+ M Y + + H P ++ G AG +A+ T P DV
Sbjct: 229 TTQLTMNVPFQAIHFMTY---EFLQEHFNPQRRYNPSSHVLSGACAGAVAAAATTPLDVC 285
Query: 242 KTHMQLYPL---------KFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTV 292
KT + + A +++ G+ +F+G R + + A+AW+V
Sbjct: 286 KTLLNTQESLALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSV 345
Query: 293 YE 294
YE
Sbjct: 346 YE 347
Score = 39.3 bits (90), Expect = 0.004
Identities = 40/201 (19%), Positives = 78/201 (38%), Gaps = 18/201 (8%)
Query: 23 MLHPVIKAFLCGSISGTCSTLL----FQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVV 78
++HP + + +G +TLL P +++K R+Q H + + V
Sbjct: 162 VIHPGGNSHIANGAAGCVATLLHDAAMNPAEVVKQRMQMYNSPYHR-----VTDCVRAVW 216
Query: 79 RTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESVMLGVGSRSVAG 138
+ E ++ + + VP I+F T L+++F V+ G + +VA
Sbjct: 217 QNEGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQEHFNPQRRYNPSSHVLSGACAGAVAA 276
Query: 139 VCMSPITVIKTRYESGKY---------GYESIYAALRSIYHSEGHRGLFSGLTATLLRDA 189
+P+ V KT + + + +A R++Y G F G+ A ++
Sbjct: 277 AATTPLDVCKTLLNTQESLALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQI 336
Query: 190 PFSGIYLMFYNQTKNIVPHDQ 210
P + I Y K ++ Q
Sbjct: 337 PSTAIAWSVYEFFKYLITKRQ 357
>gi|219555665 solute carrier family 25, member 39 isoform a [Homo
sapiens]
Length = 359
Score = 95.9 bits (237), Expect = 4e-20
Identities = 82/314 (26%), Positives = 137/314 (43%), Gaps = 31/314 (9%)
Query: 2 IQNSRPSLLQPQDVGDTVETLMLHPVIKAFLCGSISGTCSTLLF-----QPLDLLKTRLQ 56
+Q+ RPS+ + + + L + L S+ T LL+ +PL L +
Sbjct: 39 LQSQRPSM-----ASELMPSSRLWSLSYTKLPSSLQSTGKCLLYCNGVLEPLYLCPNGAR 93
Query: 57 TLQPSDHGSRRVGMLAVLLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFL 116
+R G + +K+VR E LW G+ ++V VP IYF T Y + FL
Sbjct: 94 CATWFQDPTRFTGTMDAFVKIVRHEGTRTLWSGLPATLVMTVPATAIYF-TAYDQLKAFL 152
Query: 117 RGHPPTA--LESVMLGVGSRSVAGVCMSPITVIKTRYESGKYGYESIYAALRSIYHSEGH 174
G T+ ++ G +R +SP+ +++T+ ++ Y + A +R+ G
Sbjct: 153 CGRALTSDLYAPMVAGALARLGTVTVISPLELMRTKLQAQHVSYRELGACVRTAVAQGGW 212
Query: 175 RGLFSGLTATLLRDAPFSGIYLMFYNQTKNIV----PHDQVDATLIPITNFSCGIFAGIL 230
R L+ G T LRD PFS +Y Y K+ + P DQ + +F G +G +
Sbjct: 213 RSLWLGWGPTALRDVPFSALYWFNYELVKSWLNGFRPKDQTSVGM----SFVAGGISGTV 268
Query: 231 ASLVTQPADVIKTHMQ----------LYPLKFQWIGQAVTLIFKDYGLRGFFQGGIPRAL 280
A+++T P DV+KT Q + PL + I + G +G F G +PR +
Sbjct: 269 AAVLTLPFDVVKTQRQVALGAMEAVRVNPLHVDSTWLLLRRIRAESGTKGLFAGFLPRII 328
Query: 281 RRTLMAAMAWTVYE 294
+ A+ + YE
Sbjct: 329 KAAPSCAIMISTYE 342
Score = 58.2 bits (139), Expect = 9e-09
Identities = 57/205 (27%), Positives = 89/205 (43%), Gaps = 34/205 (16%)
Query: 28 IKAFLCGS----------ISGTCSTL----LFQPLDLLKTRLQTLQPSDHGSRRVGMLAV 73
+KAFLCG ++G + L + PL+L++T+LQ S R +G A
Sbjct: 148 LKAFLCGRALTSDLYAPMVAGALARLGTVTVISPLELMRTKLQAQHVS---YRELG--AC 202
Query: 74 LLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESV----ML 129
+ V LW G P+ +R VP +Y+ Y L + +L G P SV +
Sbjct: 203 VRTAVAQGGWRSLWLGWGPTALRDVPFSALYWFN-YELVKSWLNGFRPKDQTSVGMSFVA 261
Query: 130 GVGSRSVAGVCMSPITVIKTRYESGKYGYESI----------YAALRSIYHSEGHRGLFS 179
G S +VA V P V+KT+ + E++ + LR I G +GLF+
Sbjct: 262 GGISGTVAAVLTLPFDVVKTQRQVALGAMEAVRVNPLHVDSTWLLLRRIRAESGTKGLFA 321
Query: 180 GLTATLLRDAPFSGIYLMFYNQTKN 204
G +++ AP I + Y K+
Sbjct: 322 GFLPRIIKAAPSCAIMISTYEFGKS 346
>gi|46094065 mitochondrial carrier family protein [Homo sapiens]
Length = 338
Score = 95.5 bits (236), Expect = 5e-20
Identities = 68/239 (28%), Positives = 110/239 (46%), Gaps = 15/239 (6%)
Query: 69 GMLAVLLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLR---GHPPTALE 125
G L K++R E + LW G+ P++V VP IYF T Y LR G T +
Sbjct: 86 GTLDAFFKIIRNEGIKSLWSGLPPTLVMAVPATVIYF-TCYDQLSALLRSKLGENETCIP 144
Query: 126 SVMLGVGSRSVAGVCMSPITVIKTRYESGKYGYESIYAALRSIYHSEGHRGLFSGLTATL 185
++ G+ +R A +SP+ +I+T+ +S K+ Y ++ + +G L+ G T+
Sbjct: 145 -IVAGIVARFGAVTVISPLELIRTKMQSKKFSYVELHRFVSKKVSEDGWISLWRGWAPTV 203
Query: 186 LRDAPFSGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHM 245
LRD PFS +Y Y K + + NF+ G +G A++ T P DV+KT
Sbjct: 204 LRDVPFSAMYWYNYEILKKWLCEKSGLYEPTFMINFTSGALSGSFAAVATLPFDVVKTQK 263
Query: 246 QLYPLKFQW------IGQAVTLIFKDY----GLRGFFQGGIPRALRRTLMAAMAWTVYE 294
Q ++ + + +I K+ G G F G IPR ++ A+ + YE
Sbjct: 264 QTQLWTYESHKISMPLHMSTWIIMKNIVAKNGFSGLFSGLIPRLIKIAPACAIMISTYE 322
Score = 51.2 bits (121), Expect = 1e-06
Identities = 40/138 (28%), Positives = 62/138 (44%), Gaps = 4/138 (2%)
Query: 158 YESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTKNIVPHD-QVDATLI 216
++ A I +EG + L+SGL TL+ P + IY Y+Q ++ + T I
Sbjct: 84 FQGTLDAFFKIIRNEGIKSLWSGLPPTLVMAVPATVIYFTCYDQLSALLRSKLGENETCI 143
Query: 217 PITNFSCGIFAGILASLVTQPADVIKTHMQLYPLKFQWIGQAVTLIFKDYGLRGFFQGGI 276
PI GI A A V P ++I+T MQ + + + V+ + G ++G
Sbjct: 144 PIV---AGIVARFGAVTVISPLELIRTKMQSKKFSYVELHRFVSKKVSEDGWISLWRGWA 200
Query: 277 PRALRRTLMAAMAWTVYE 294
P LR +AM W YE
Sbjct: 201 PTVLRDVPFSAMYWYNYE 218
Score = 37.7 bits (86), Expect = 0.013
Identities = 23/91 (25%), Positives = 43/91 (47%), Gaps = 7/91 (7%)
Query: 31 FLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGM------LAVLLKVVRTESLL 84
F G++SG+ + + P D++KT+ QT Q + S ++ M ++ +V
Sbjct: 239 FTSGALSGSFAAVATLPFDVVKTQKQT-QLWTYESHKISMPLHMSTWIIMKNIVAKNGFS 297
Query: 85 GLWKGMSPSIVRCVPGVGIYFGTLYSLKQYF 115
GL+ G+ P +++ P I T K +F
Sbjct: 298 GLFSGLIPRLIKIAPACAIMISTYEFGKAFF 328
>gi|27544933 solute carrier family 25, member 16 [Homo sapiens]
Length = 332
Score = 94.7 bits (234), Expect = 9e-20
Identities = 79/296 (26%), Positives = 132/296 (44%), Gaps = 34/296 (11%)
Query: 28 IKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGLW 87
+++FL G I+G C+ PLD +K LQ +H + +G+ + L V + E LGL+
Sbjct: 37 LRSFLAGGIAGCCAKTTVAPLDRVKVLLQA---HNHHYKHLGVFSALRAVPQKEGFLGLY 93
Query: 88 KGMSPSIVRCVPGVGIYFGTLYSLKQYF-----LRGHPPTALESVMLGVGSRSVAGVCMS 142
KG ++R P I F K + GH + +M G + A +C
Sbjct: 94 KGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGH----VHRLMAGSMAGMTAVICTY 149
Query: 143 PITVIKTRYE---SGKYGYESIYAALRSIYHSE-GHRGLFSGLTATLLRDAPFSGIYLMF 198
P+ +++ R G++ Y I A ++IY E G G + GL T+L AP++G+
Sbjct: 150 PLDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFT 209
Query: 199 YNQTKNI----------VPHDQVDATLIPIT--NFSCGIFAGILASLVTQPADVIKTHMQ 246
+ K++ P L+ T N CG AG +A ++ P DV + MQ
Sbjct: 210 FGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQ 269
Query: 247 LYPL-----KFQWIGQAVTLIFKDYGLR-GFFQGGIPRALRRTLMAAMAWTVYEEM 296
L + K + + ++ +G+R G ++G +R A+A+T YE M
Sbjct: 270 LGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELM 325
Score = 42.4 bits (98), Expect = 5e-04
Identities = 29/111 (26%), Positives = 52/111 (46%), Gaps = 5/111 (4%)
Query: 7 PSLL-QPQDVGDTVETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGS 65
P+LL +P V L H + LCG ++G + + P D+ + R+Q
Sbjct: 222 PTLLGRPSSDNPNVLVLKTHVNL---LCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFE 278
Query: 66 RRVGMLAVLLKVVRTESLL-GLWKGMSPSIVRCVPGVGIYFGTLYSLKQYF 115
+ + M + V + GL++G+S + +RC+P + F T +KQ+F
Sbjct: 279 KCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQFF 329
>gi|7706306 solute carrier family 25, member 39 isoform b [Homo
sapiens]
Length = 351
Score = 94.0 bits (232), Expect = 1e-19
Identities = 69/246 (28%), Positives = 113/246 (45%), Gaps = 21/246 (8%)
Query: 65 SRRVGMLAVLLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTA- 123
+R G + +K+VR E LW G+ ++V VP IYF T Y + FL G T+
Sbjct: 94 TRFTGTMDAFVKIVRHEGTRTLWSGLPATLVMTVPATAIYF-TAYDQLKAFLCGRALTSD 152
Query: 124 -LESVMLGVGSRSVAGVCMSPITVIKTRYESGKYGYESIYAALRSIYHSEGHRGLFSGLT 182
++ G +R +SP+ +++T+ ++ Y + A +R+ G R L+ G
Sbjct: 153 LYAPMVAGALARLGTVTVISPLELMRTKLQAQHVSYRELGACVRTAVAQGGWRSLWLGWG 212
Query: 183 ATLLRDAPFSGIYLMFYNQTKNIV----PHDQVDATLIPITNFSCGIFAGILASLVTQPA 238
T LRD PFS +Y Y K+ + P DQ + +F G +G +A+++T P
Sbjct: 213 PTALRDVPFSALYWFNYELVKSWLNGFRPKDQTSVGM----SFVAGGISGTVAAVLTLPF 268
Query: 239 DVIKTHMQ----------LYPLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAM 288
DV+KT Q + PL + I + G +G F G +PR ++ A+
Sbjct: 269 DVVKTQRQVALGAMEAVRVNPLHVDSTWLLLRRIRAESGTKGLFAGFLPRIIKAAPSCAI 328
Query: 289 AWTVYE 294
+ YE
Sbjct: 329 MISTYE 334
Score = 58.2 bits (139), Expect = 9e-09
Identities = 57/205 (27%), Positives = 89/205 (43%), Gaps = 34/205 (16%)
Query: 28 IKAFLCGS----------ISGTCSTL----LFQPLDLLKTRLQTLQPSDHGSRRVGMLAV 73
+KAFLCG ++G + L + PL+L++T+LQ S R +G A
Sbjct: 140 LKAFLCGRALTSDLYAPMVAGALARLGTVTVISPLELMRTKLQAQHVS---YRELG--AC 194
Query: 74 LLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESV----ML 129
+ V LW G P+ +R VP +Y+ Y L + +L G P SV +
Sbjct: 195 VRTAVAQGGWRSLWLGWGPTALRDVPFSALYWFN-YELVKSWLNGFRPKDQTSVGMSFVA 253
Query: 130 GVGSRSVAGVCMSPITVIKTRYESGKYGYESI----------YAALRSIYHSEGHRGLFS 179
G S +VA V P V+KT+ + E++ + LR I G +GLF+
Sbjct: 254 GGISGTVAAVLTLPFDVVKTQRQVALGAMEAVRVNPLHVDSTWLLLRRIRAESGTKGLFA 313
Query: 180 GLTATLLRDAPFSGIYLMFYNQTKN 204
G +++ AP I + Y K+
Sbjct: 314 GFLPRIIKAAPSCAIMISTYEFGKS 338
Score = 44.3 bits (103), Expect = 1e-04
Identities = 30/93 (32%), Positives = 45/93 (48%), Gaps = 5/93 (5%)
Query: 30 AFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSR----RVGMLAVLLKVVRTES-LL 84
+F+ G ISGT + +L P D++KT+ Q + R V +LL+ +R ES
Sbjct: 250 SFVAGGISGTVAAVLTLPFDVVKTQRQVALGAMEAVRVNPLHVDSTWLLLRRIRAESGTK 309
Query: 85 GLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLR 117
GL+ G P I++ P I T K +F R
Sbjct: 310 GLFAGFLPRIIKAAPSCAIMISTYEFGKSFFQR 342
>gi|13259541 uncoupling protein 2 [Homo sapiens]
Length = 309
Score = 90.1 bits (222), Expect = 2e-18
Identities = 71/280 (25%), Positives = 129/280 (46%), Gaps = 16/280 (5%)
Query: 31 FLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRV-------GMLAVLLKVVRTESL 83
FL + + L+ PLD K RLQ +Q G R G++ +L +VRTE
Sbjct: 17 FLGAGTAACIADLITFPLDTAKVRLQ-IQGESQGPVRATASAQYRGVMGTILTMVRTEGP 75
Query: 84 LGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESVML-GVGSRSVAGVCMS 142
L+ G+ + R + + G S+KQ++ +G ++ S +L G + ++A
Sbjct: 76 RSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQ 135
Query: 143 PITVIKTRYES-----GKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLM 197
P V+K R+++ G Y+S A ++I EG RGL+ G + + R+A + L+
Sbjct: 136 PTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELV 195
Query: 198 FYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQLYPL-KFQWIG 256
Y+ K+ + + +P +F+ AG +++ P DV+KT L ++ G
Sbjct: 196 TYDLIKDALLKANLMTDDLP-CHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAG 254
Query: 257 QAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEM 296
+ + G R F++G +P LR + + YE++
Sbjct: 255 HCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQL 294
Score = 64.7 bits (156), Expect = 1e-10
Identities = 49/177 (27%), Positives = 75/177 (42%), Gaps = 7/177 (3%)
Query: 32 LCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGLWKGMS 91
L GS +G + + QP D++K R Q + G R + + R E GLWKG S
Sbjct: 121 LAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTS 180
Query: 92 PSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESVMLGVGSRSVAGVC----MSPITVI 147
P++ R T +K L+ + T + + S AG C SP+ V+
Sbjct: 181 PNVARNAIVNCAELVTYDLIKDALLKANLMT--DDLPCHFTSAFGAGFCTTVIASPVDVV 238
Query: 148 KTRYESGKYG-YESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTK 203
KTRY + G Y S ++ EG R + G + LR ++ + + Y Q K
Sbjct: 239 KTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLK 295
>gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens]
Length = 301
Score = 89.7 bits (221), Expect = 3e-18
Identities = 74/264 (28%), Positives = 115/264 (43%), Gaps = 23/264 (8%)
Query: 28 IKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRV--GMLAVLLKVVRTESLLG 85
+K L G G C + PLD +K RLQT PS G + G K + E + G
Sbjct: 11 LKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITG 70
Query: 86 LWKGMSPSIVRCVPGVGI-YFGTLYSLKQYFLRGHPPTALESVMLGVGSRSVAGVCMSPI 144
L++GM+ I+ P + +FG + L + + HP L L + ++GV + I
Sbjct: 71 LYRGMAAPIIGVTPMFAVCFFG--FGLGKKLQQKHPEDVLSYPQL-FAAGMLSGVFTTGI 127
Query: 145 T--------VIKTRYESGKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYL 196
+++ + SG+ Y + +Y G RG++ G TL+RD P SG+Y
Sbjct: 128 MTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYF 187
Query: 197 MFYNQTKNI-VPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQL-----YPL 250
M Y KNI P + + L G AGI V P DV+K+ Q YP
Sbjct: 188 MTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYPN 247
Query: 251 KFQWIGQAVTLIFKDYGLRGFFQG 274
F+ + + +D G+ ++G
Sbjct: 248 GFR---DVLRELIRDEGVTSLYKG 268
Score = 47.0 bits (110), Expect = 2e-05
Identities = 37/190 (19%), Positives = 77/190 (40%), Gaps = 20/190 (10%)
Query: 120 PPTALESVMLGVGSRSVAGVCM----SPITVIKTRYESGKYG-------YESIYAALRSI 168
P + L++++ G GVC+ P+ +K R ++ Y + R
Sbjct: 7 PISPLKNLLAG----GFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKT 62
Query: 169 YHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAG 228
EG GL+ G+ A ++ P + + K + D P F+ G+ +G
Sbjct: 63 LFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQL-FAAGMLSG 121
Query: 229 ILASLVTQPADVIKTHMQLYPL----KFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTL 284
+ + + P + IK +Q+ K+ +++++G+RG ++G + +R
Sbjct: 122 VFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVP 181
Query: 285 MAAMAWTVYE 294
+ M + YE
Sbjct: 182 ASGMYFMTYE 191
>gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo
sapiens]
Length = 325
Score = 89.4 bits (220), Expect = 4e-18
Identities = 80/287 (27%), Positives = 138/287 (48%), Gaps = 27/287 (9%)
Query: 29 KAFLCGSISGTCSTLLFQPLDLLKTRLQTL-QPSDHGSRRV---GMLAVLLKVVRTESLL 84
K F+ G ++ + P+DL KTRLQ Q D + + GM L ++ + E +L
Sbjct: 42 KPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVL 101
Query: 85 GLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFL-RGHPPTALESVMLGVGSRSVAGVCMSP 143
L+ G++P+++R I G SLK+ F+ R T L +++ GV S ++ +P
Sbjct: 102 ALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANP 161
Query: 144 ITVIKTRYES-GKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQT 202
V+K R ++ G S+ + IY EG RGL+ G+ T R A G+ L Y+ T
Sbjct: 162 TDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDIT 221
Query: 203 -KNIVPHDQVDATLIP--ITNFSCGIFAGILASLVTQPADVIKT----------HMQLYP 249
K+++ + T++ +++F+CG+ AG LAS P DV++T H+ LY
Sbjct: 222 KKHLILSGMMGDTILTHFVSSFTCGL-AGALAS---NPVDVVRTRMMNQRAIVGHVDLY- 276
Query: 250 LKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEM 296
+ + ++K G ++G P LR + + YE++
Sbjct: 277 ---KGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQL 320
Score = 61.6 bits (148), Expect = 8e-10
Identities = 50/195 (25%), Positives = 90/195 (46%), Gaps = 19/195 (9%)
Query: 20 ETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVR 79
ETL+++ +CG +SG S+ + P D+LK R+Q GS M+ + + +
Sbjct: 139 ETLLIN-----MICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGS----MIGSFIDIYQ 189
Query: 80 TESLLGLWKGMSPSIVRCVPGVGIYFGTLYSL--KQYFLRGHPPTALESVMLGVGSRSVA 137
E GLW+G+ P+ R VG+ +Y + K L G + + + + +A
Sbjct: 190 QEGTRGLWRGVVPTAQRAAIVVGVEL-PVYDITKKHLILSGMMGDTILTHFVSSFTCGLA 248
Query: 138 GVCMS-PITVIKTRYESGK--YGYESIYA----ALRSIYHSEGHRGLFSGLTATLLRDAP 190
G S P+ V++TR + + G+ +Y + ++ EG L+ G LR P
Sbjct: 249 GALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGP 308
Query: 191 FSGIYLMFYNQTKNI 205
++ I+ + Y Q K +
Sbjct: 309 WNIIFFITYEQLKRL 323
>gi|13259543 solute carrier family 25, member 14 isoform UCP5S [Homo
sapiens]
Length = 322
Score = 89.4 bits (220), Expect = 4e-18
Identities = 80/287 (27%), Positives = 138/287 (48%), Gaps = 27/287 (9%)
Query: 29 KAFLCGSISGTCSTLLFQPLDLLKTRLQTL-QPSDHGSRRV---GMLAVLLKVVRTESLL 84
K F+ G ++ + P+DL KTRLQ Q D + + GM L ++ + E +L
Sbjct: 39 KPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVL 98
Query: 85 GLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFL-RGHPPTALESVMLGVGSRSVAGVCMSP 143
L+ G++P+++R I G SLK+ F+ R T L +++ GV S ++ +P
Sbjct: 99 ALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANP 158
Query: 144 ITVIKTRYES-GKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQT 202
V+K R ++ G S+ + IY EG RGL+ G+ T R A G+ L Y+ T
Sbjct: 159 TDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDIT 218
Query: 203 -KNIVPHDQVDATLIP--ITNFSCGIFAGILASLVTQPADVIKT----------HMQLYP 249
K+++ + T++ +++F+CG+ AG LAS P DV++T H+ LY
Sbjct: 219 KKHLILSGMMGDTILTHFVSSFTCGL-AGALAS---NPVDVVRTRMMNQRAIVGHVDLY- 273
Query: 250 LKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEM 296
+ + ++K G ++G P LR + + YE++
Sbjct: 274 ---KGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQL 317
Score = 61.6 bits (148), Expect = 8e-10
Identities = 50/195 (25%), Positives = 90/195 (46%), Gaps = 19/195 (9%)
Query: 20 ETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVR 79
ETL+++ +CG +SG S+ + P D+LK R+Q GS M+ + + +
Sbjct: 136 ETLLIN-----MICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGS----MIGSFIDIYQ 186
Query: 80 TESLLGLWKGMSPSIVRCVPGVGIYFGTLYSL--KQYFLRGHPPTALESVMLGVGSRSVA 137
E GLW+G+ P+ R VG+ +Y + K L G + + + + +A
Sbjct: 187 QEGTRGLWRGVVPTAQRAAIVVGVEL-PVYDITKKHLILSGMMGDTILTHFVSSFTCGLA 245
Query: 138 GVCMS-PITVIKTRYESGK--YGYESIYA----ALRSIYHSEGHRGLFSGLTATLLRDAP 190
G S P+ V++TR + + G+ +Y + ++ EG L+ G LR P
Sbjct: 246 GALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGP 305
Query: 191 FSGIYLMFYNQTKNI 205
++ I+ + Y Q K +
Sbjct: 306 WNIIFFITYEQLKRL 320
>gi|58197562 solute carrier family 25, member 30 [Homo sapiens]
Length = 291
Score = 87.8 bits (216), Expect = 1e-17
Identities = 86/287 (29%), Positives = 141/287 (49%), Gaps = 26/287 (9%)
Query: 29 KAFLCG---SISGTCSTLLFQPLDLLKTRLQTL-QPSDHGSRRV---GMLAVLLKVVRTE 81
K F+ G SI+ C T P+DL KTRLQ Q +D + + GML L+++ R E
Sbjct: 7 KPFVYGGLASITAECGTF---PIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREE 63
Query: 82 SLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFL-RGHPPTALESVMLGVGSRSVAGVC 140
L L+ G++P+++R I GT SLK+ F+ R T +V+ G+ S ++
Sbjct: 64 GLKALYSGIAPAMLRQASYGTIKIGTYQSLKRLFIERPEDETLPINVICGILSGVISSTI 123
Query: 141 MSPITVIKTRYESGKYGYE-SIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFY 199
+P V+K R ++ + + +IY EG RGL+ G++ T R A G+ L Y
Sbjct: 124 ANPTDVLKIRMQAQSNTIQGGMIGNFMNIYQQEGTRGLWKGVSLTAQRAAIVVGVELPVY 183
Query: 200 NQT-KNIVPHDQVDATLIP--ITNFSCGIFAGILASLVTQPADVIKTHM--QLYPLKFQW 254
+ T K+++ + T+ +++F+CG+ AG LAS P DV++T M Q +
Sbjct: 184 DITKKHLILSGLMGDTVYTHFLSSFTCGL-AGALAS---NPVDVVRTRMMNQRVLRDGRC 239
Query: 255 IGQAVTL-----IFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEM 296
G TL +K+ G ++G P LR + + YE++
Sbjct: 240 SGYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQL 286
Score = 65.1 bits (157), Expect = 7e-11
Identities = 50/184 (27%), Positives = 83/184 (45%), Gaps = 15/184 (8%)
Query: 32 LCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGLWKGMS 91
+CG +SG S+ + P D+LK R+Q + G GM+ + + + E GLWKG+S
Sbjct: 111 ICGILSGVISSTIANPTDVLKIRMQAQSNTIQG----GMIGNFMNIYQQEGTRGLWKGVS 166
Query: 92 PSIVRCVPGVGIYFGTLYSL--KQYFLRGHPPTALESVMLGVGSRSVAGVCMS-PITVIK 148
+ R VG+ +Y + K L G + + L + +AG S P+ V++
Sbjct: 167 LTAQRAAIVVGVEL-PVYDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVR 225
Query: 149 TRYESGKY-------GYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQ 201
TR + + GY L + +EG L+ G LR P++ I+ + Y Q
Sbjct: 226 TRMMNQRVLRDGRCSGYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQ 285
Query: 202 TKNI 205
K +
Sbjct: 286 LKKL 289
Score = 40.0 bits (92), Expect = 0.003
Identities = 32/101 (31%), Positives = 47/101 (46%), Gaps = 10/101 (9%)
Query: 15 VGDTVETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHG--SRRVGMLA 72
+GDTV T L +F CG S P+D+++TR+ + G S G L
Sbjct: 196 MGDTVYTHFL----SSFTCGLAGALASN----PVDVVRTRMMNQRVLRDGRCSGYTGTLD 247
Query: 73 VLLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQ 113
LL+ + E L+KG P+ +R P I+F T LK+
Sbjct: 248 CLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQLKK 288
>gi|86198310 solute carrier family 25, member 29 [Homo sapiens]
Length = 303
Score = 87.8 bits (216), Expect = 1e-17
Identities = 73/261 (27%), Positives = 120/261 (45%), Gaps = 18/261 (6%)
Query: 31 FLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGLWKGM 90
FL G G L+ P D +K RLQ R G L +++ ES+LGL+KG+
Sbjct: 5 FLAGCAGGVAGVLVGHPFDTVKVRLQVQSVEKPQYR--GTLHCFKSIIKQESVLGLYKGL 62
Query: 91 SPSIVRCVPGVGIYFGTLYSLKQYFLR--GHPPTALESVMLGVGSRSVAGVCMSPITVIK 148
++ G+ ++ ++ LR GH + L + G + ++ V P+ + K
Sbjct: 63 GSPLM----GLTFINALVFGVQGNTLRALGHD-SPLNQFLAGAAAGAIQCVICCPMELAK 117
Query: 149 TRYESGKYG----YESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTKN 204
TR + G Y+ L IY EG RG+ G+ +TLLR+ P G+Y + Y+
Sbjct: 118 TRLQLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLTYDALTR 177
Query: 205 IVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQLYPL----KFQWIGQAVT 260
+ + D L+P + G +GI++ L T P DV+K+ +Q L +++ I V
Sbjct: 178 ALGCEPGDRLLVPKLLLAGGT-SGIVSWLSTYPVDVVKSRLQADGLRGAPRYRGILDCVH 236
Query: 261 LIFKDYGLRGFFQGGIPRALR 281
++ G R F +G LR
Sbjct: 237 QSYRAEGWRVFTRGLASTLLR 257
Score = 68.2 bits (165), Expect = 9e-12
Identities = 55/182 (30%), Positives = 86/182 (47%), Gaps = 9/182 (4%)
Query: 16 GDTVETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLL 75
G+T+ L + FL G+ +G ++ P++L KTRLQ LQ + G L L
Sbjct: 81 GNTLRALGHDSPLNQFLAGAAAGAIQCVICCPMELAKTRLQ-LQDAGPARTYKGSLDCLA 139
Query: 76 KVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTAL---ESVMLGVG 132
++ E L G+ +GM +++R P G+YF T Y L P L + ++ G
Sbjct: 140 QIYGHEGLRGVNRGMVSTLLRETPSFGVYFLT-YDALTRALGCEPGDRLLVPKLLLAGGT 198
Query: 133 SRSVAGVCMSPITVIKTRYES----GKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRD 188
S V+ + P+ V+K+R ++ G Y I + Y +EG R GL +TLLR
Sbjct: 199 SGIVSWLSTYPVDVVKSRLQADGLRGAPRYRGILDCVHQSYRAEGWRVFTRGLASTLLRA 258
Query: 189 AP 190
P
Sbjct: 259 FP 260
>gi|82775373 solute carrier family 25, member 37 [Homo sapiens]
Length = 338
Score = 87.0 bits (214), Expect = 2e-17
Identities = 66/275 (24%), Positives = 124/275 (45%), Gaps = 19/275 (6%)
Query: 34 GSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGLWKGMSPS 93
G+++G + P+D +KTR+Q+L P D ++ + L K++RTE +G++
Sbjct: 52 GAMAGILEHSVMYPVDSVKTRMQSLSP-DPKAQYTSIYGALKKIMRTEGFWRPLRGVNVM 110
Query: 94 IVRCVPGVGIYFGTLYSLKQYF---LRGHPPTALESVMLGVGSRSVAGVCMSPITVIKTR 150
I+ P +YF ++K+ + L + + G + + M+P V+K R
Sbjct: 111 IMGAGPAHAMYFACYENMKRTLNDVFHHQGNSHLANGIAGSMATLLHDAVMNPAEVVKQR 170
Query: 151 YESGKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYN-QTKNIVPHD 209
+ + S + +R+++ +EG + T L + PF I+ + Y + + PH
Sbjct: 171 LQMYNSQHRSAISCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYEFLQEQVNPH- 229
Query: 210 QVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQLYPL----------KFQWIGQAV 259
T P ++ G AG LA+ T P DV KT + + + A
Sbjct: 230 ---RTYNPQSHIISGGLAGALAAAATTPLDVCKTLLNTQENVALSLANISGRLSGMANAF 286
Query: 260 TLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYE 294
+++ GL G+F+G R + + A++W+VYE
Sbjct: 287 RTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYE 321
Score = 43.9 bits (102), Expect = 2e-04
Identities = 47/207 (22%), Positives = 86/207 (41%), Gaps = 25/207 (12%)
Query: 23 MLHPVIKAFLCGSISGTCSTLL----FQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVV 78
+ H + L I+G+ +TLL P +++K RLQ + S+ ++ + V
Sbjct: 135 VFHHQGNSHLANGIAGSMATLLHDAVMNPAEVVKQRLQM-----YNSQHRSAISCIRTVW 189
Query: 79 RTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESVMLGVG-SRSVA 137
RTE L ++ + + +P I+F T Y Q + H +S ++ G + ++A
Sbjct: 190 RTEGLGAFYRSYTTQLTMNIPFQSIHFIT-YEFLQEQVNPHRTYNPQSHIISGGLAGALA 248
Query: 138 GVCMSPITVIKTRYE------------SGKYGYESIYAALRSIYHSEGHRGLFSGLTATL 185
+P+ V KT SG+ + A R++Y G G F G+ A +
Sbjct: 249 AAATTPLDVCKTLLNTQENVALSLANISGRLS--GMANAFRTVYQLNGLAGYFKGIQARV 306
Query: 186 LRDAPFSGIYLMFYNQTKNIVPHDQVD 212
+ P + I Y K + Q++
Sbjct: 307 IYQMPSTAISWSVYEFFKYFLTKRQLE 333
Score = 28.5 bits (62), Expect = 7.7
Identities = 13/28 (46%), Positives = 16/28 (57%)
Query: 219 TNFSCGIFAGILASLVTQPADVIKTHMQ 246
T+ + G AGIL V P D +KT MQ
Sbjct: 47 THMTAGAMAGILEHSVMYPVDSVKTRMQ 74
>gi|11225256 uncoupling protein 1 [Homo sapiens]
Length = 307
Score = 86.3 bits (212), Expect = 3e-17
Identities = 73/290 (25%), Positives = 128/290 (44%), Gaps = 15/290 (5%)
Query: 24 LHPVIKAFLCGSISGTC-STLLFQPLDLLKTRLQTLQ--PSDHGSRRVGMLAVLLKVVRT 80
+HP + L + C + ++ PLD K RLQ P+ R G+L + VV+T
Sbjct: 9 VHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKT 68
Query: 81 ESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALE---SVMLGVGSRSVA 137
E + L+ G+ + R + + G LY Q FL TA ++ G+ + VA
Sbjct: 69 EGRMKLYSGLPAGLQRQISSASLRIG-LYDTVQEFLTAGKETAPSLGSKILAGLTTGGVA 127
Query: 138 GVCMSPITVIKTRYESGKY------GYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPF 191
P V+K R ++ + Y Y A R I +EG GL+ G T L+R
Sbjct: 128 VFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVII 187
Query: 192 SGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTH-MQLYPL 250
+ L+ Y+ K + + A +P + + AG A+ ++ P DV+KT + P
Sbjct: 188 NCTELVTYDLMKEAFVKNNILADDVP-CHLVSALIAGFCATAMSSPVDVVKTRFINSPPG 246
Query: 251 KFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEMMAKM 300
+++ + +F + G FF+G +P LR + + +E++ ++
Sbjct: 247 QYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKREL 296
>gi|186928856 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 86.3 bits (212), Expect = 3e-17
Identities = 69/289 (23%), Positives = 128/289 (44%), Gaps = 30/289 (10%)
Query: 32 LCGSISGTCSTLLFQPLDLLKTRLQT----LQPSDHGSRRVGMLAVLLKVVRTESLLGLW 87
+ GS+SG + L P D++K R Q L SD ++ G+L ++++ E W
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 88 KGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALE---SVMLGVGSRSVAGVCMSPI 144
KG P+ + + + F + L + RG A E + G + +A + + P+
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139
Query: 145 TVIKTRYESGKYGYESIYAALR----SIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYN 200
V++TR+ + G +Y LR ++Y SEG + + GL TL+ P++G+ Y+
Sbjct: 140 DVLRTRFAA--QGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYS 197
Query: 201 QTKNI----VPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQL--------- 247
K++ +P + + N CG AG+++ +T P D+ K +Q+
Sbjct: 198 SLKHLYKWAIPAEGKKNE--NLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAA 255
Query: 248 --YPLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYE 294
+++ + + + G GFF+G P L+ L + YE
Sbjct: 256 FGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
Score = 62.8 bits (151), Expect = 4e-10
Identities = 46/194 (23%), Positives = 86/194 (44%), Gaps = 25/194 (12%)
Query: 31 FLCGSISGTCSTLLFQPLDLLKTRLQTL-QPSDHGSRR--VGMLAVLLKVVRTESLLGLW 87
F+CG ++ +TL P+D+L+TR +P + + R VG + R+E +
Sbjct: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTM------YRSEGPQVFY 175
Query: 88 KGMSPSIVRCVPGVGIYFGTLYSLKQYF-----LRGHPPTALESVMLGVGSRSVAGVCMS 142
KG++P+++ P G+ F SLK + G L++++ G G+ ++
Sbjct: 176 KGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTY 235
Query: 143 PITVIKTRYESGKY-----------GYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPF 191
P+ + K R + G + Y+ + + + EG G F GL+ +LL+ A
Sbjct: 236 PLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALS 295
Query: 192 SGIYLMFYNQTKNI 205
+G Y N+
Sbjct: 296 TGFMFFSYEFFCNV 309
Score = 49.3 bits (116), Expect = 4e-06
Identities = 41/190 (21%), Positives = 71/190 (37%), Gaps = 11/190 (5%)
Query: 118 GHPPTALESVMLGVGSRSVAGVCMSPITVIKTRYE---------SGKYGYESIYAALRSI 168
G T + + G S V +SP VIK R++ Y I A R I
Sbjct: 10 GRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQI 69
Query: 169 YHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAG 228
EG + G + + + + + +V V +F CG A
Sbjct: 70 LQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAA 129
Query: 229 ILASLVTQPADVIKTHM--QLYPLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMA 286
+A+L P DV++T Q P + + AV +++ G + F++G P + A
Sbjct: 130 CMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYA 189
Query: 287 AMAWTVYEEM 296
+ ++ Y +
Sbjct: 190 GLQFSCYSSL 199
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 8/85 (9%)
Query: 28 IKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHG-------SRRVGMLAVLLKVVRT 80
++ LCGS +G S L PLDL K RLQ + +H R G++ +V++
Sbjct: 217 LQNLLCGSGAGVISKTLTYPLDLFKKRLQ-VGGFEHARAAFGQVRRYKGLMDCAKQVLQK 275
Query: 81 ESLLGLWKGMSPSIVRCVPGVGIYF 105
E LG +KG+SPS+++ G F
Sbjct: 276 EGALGFFKGLSPSLLKAALSTGFMF 300
>gi|186928860 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 86.3 bits (212), Expect = 3e-17
Identities = 69/289 (23%), Positives = 128/289 (44%), Gaps = 30/289 (10%)
Query: 32 LCGSISGTCSTLLFQPLDLLKTRLQT----LQPSDHGSRRVGMLAVLLKVVRTESLLGLW 87
+ GS+SG + L P D++K R Q L SD ++ G+L ++++ E W
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 88 KGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALE---SVMLGVGSRSVAGVCMSPI 144
KG P+ + + + F + L + RG A E + G + +A + + P+
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139
Query: 145 TVIKTRYESGKYGYESIYAALR----SIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYN 200
V++TR+ + G +Y LR ++Y SEG + + GL TL+ P++G+ Y+
Sbjct: 140 DVLRTRFAA--QGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYS 197
Query: 201 QTKNI----VPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQL--------- 247
K++ +P + + N CG AG+++ +T P D+ K +Q+
Sbjct: 198 SLKHLYKWAIPAEGKKNE--NLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAA 255
Query: 248 --YPLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYE 294
+++ + + + G GFF+G P L+ L + YE
Sbjct: 256 FGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
Score = 62.8 bits (151), Expect = 4e-10
Identities = 46/194 (23%), Positives = 86/194 (44%), Gaps = 25/194 (12%)
Query: 31 FLCGSISGTCSTLLFQPLDLLKTRLQTL-QPSDHGSRR--VGMLAVLLKVVRTESLLGLW 87
F+CG ++ +TL P+D+L+TR +P + + R VG + R+E +
Sbjct: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTM------YRSEGPQVFY 175
Query: 88 KGMSPSIVRCVPGVGIYFGTLYSLKQYF-----LRGHPPTALESVMLGVGSRSVAGVCMS 142
KG++P+++ P G+ F SLK + G L++++ G G+ ++
Sbjct: 176 KGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTY 235
Query: 143 PITVIKTRYESGKY-----------GYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPF 191
P+ + K R + G + Y+ + + + EG G F GL+ +LL+ A
Sbjct: 236 PLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALS 295
Query: 192 SGIYLMFYNQTKNI 205
+G Y N+
Sbjct: 296 TGFMFFSYEFFCNV 309
Score = 49.3 bits (116), Expect = 4e-06
Identities = 41/190 (21%), Positives = 71/190 (37%), Gaps = 11/190 (5%)
Query: 118 GHPPTALESVMLGVGSRSVAGVCMSPITVIKTRYE---------SGKYGYESIYAALRSI 168
G T + + G S V +SP VIK R++ Y I A R I
Sbjct: 10 GRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQI 69
Query: 169 YHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAG 228
EG + G + + + + + +V V +F CG A
Sbjct: 70 LQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAA 129
Query: 229 ILASLVTQPADVIKTHM--QLYPLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMA 286
+A+L P DV++T Q P + + AV +++ G + F++G P + A
Sbjct: 130 CMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYA 189
Query: 287 AMAWTVYEEM 296
+ ++ Y +
Sbjct: 190 GLQFSCYSSL 199
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 8/85 (9%)
Query: 28 IKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHG-------SRRVGMLAVLLKVVRT 80
++ LCGS +G S L PLDL K RLQ + +H R G++ +V++
Sbjct: 217 LQNLLCGSGAGVISKTLTYPLDLFKKRLQ-VGGFEHARAAFGQVRRYKGLMDCAKQVLQK 275
Query: 81 ESLLGLWKGMSPSIVRCVPGVGIYF 105
E LG +KG+SPS+++ G F
Sbjct: 276 EGALGFFKGLSPSLLKAALSTGFMF 300
>gi|186928858 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 86.3 bits (212), Expect = 3e-17
Identities = 69/289 (23%), Positives = 128/289 (44%), Gaps = 30/289 (10%)
Query: 32 LCGSISGTCSTLLFQPLDLLKTRLQT----LQPSDHGSRRVGMLAVLLKVVRTESLLGLW 87
+ GS+SG + L P D++K R Q L SD ++ G+L ++++ E W
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 88 KGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALE---SVMLGVGSRSVAGVCMSPI 144
KG P+ + + + F + L + RG A E + G + +A + + P+
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPV 139
Query: 145 TVIKTRYESGKYGYESIYAALR----SIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYN 200
V++TR+ + G +Y LR ++Y SEG + + GL TL+ P++G+ Y+
Sbjct: 140 DVLRTRFAA--QGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYS 197
Query: 201 QTKNI----VPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQL--------- 247
K++ +P + + N CG AG+++ +T P D+ K +Q+
Sbjct: 198 SLKHLYKWAIPAEGKKNE--NLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAA 255
Query: 248 --YPLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYE 294
+++ + + + G GFF+G P L+ L + YE
Sbjct: 256 FGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
Score = 62.8 bits (151), Expect = 4e-10
Identities = 46/194 (23%), Positives = 86/194 (44%), Gaps = 25/194 (12%)
Query: 31 FLCGSISGTCSTLLFQPLDLLKTRLQTL-QPSDHGSRR--VGMLAVLLKVVRTESLLGLW 87
F+CG ++ +TL P+D+L+TR +P + + R VG + R+E +
Sbjct: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTM------YRSEGPQVFY 175
Query: 88 KGMSPSIVRCVPGVGIYFGTLYSLKQYF-----LRGHPPTALESVMLGVGSRSVAGVCMS 142
KG++P+++ P G+ F SLK + G L++++ G G+ ++
Sbjct: 176 KGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTY 235
Query: 143 PITVIKTRYESGKY-----------GYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPF 191
P+ + K R + G + Y+ + + + EG G F GL+ +LL+ A
Sbjct: 236 PLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALS 295
Query: 192 SGIYLMFYNQTKNI 205
+G Y N+
Sbjct: 296 TGFMFFSYEFFCNV 309
Score = 49.3 bits (116), Expect = 4e-06
Identities = 41/190 (21%), Positives = 71/190 (37%), Gaps = 11/190 (5%)
Query: 118 GHPPTALESVMLGVGSRSVAGVCMSPITVIKTRYE---------SGKYGYESIYAALRSI 168
G T + + G S V +SP VIK R++ Y I A R I
Sbjct: 10 GRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQI 69
Query: 169 YHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAG 228
EG + G + + + + + +V V +F CG A
Sbjct: 70 LQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAA 129
Query: 229 ILASLVTQPADVIKTHM--QLYPLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMA 286
+A+L P DV++T Q P + + AV +++ G + F++G P + A
Sbjct: 130 CMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYA 189
Query: 287 AMAWTVYEEM 296
+ ++ Y +
Sbjct: 190 GLQFSCYSSL 199
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 8/85 (9%)
Query: 28 IKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHG-------SRRVGMLAVLLKVVRT 80
++ LCGS +G S L PLDL K RLQ + +H R G++ +V++
Sbjct: 217 LQNLLCGSGAGVISKTLTYPLDLFKKRLQ-VGGFEHARAAFGQVRRYKGLMDCAKQVLQK 275
Query: 81 ESLLGLWKGMSPSIVRCVPGVGIYF 105
E LG +KG+SPS+++ G F
Sbjct: 276 EGALGFFKGLSPSLLKAALSTGFMF 300
>gi|21314739 solute carrier family 25, member 32 [Homo sapiens]
Length = 315
Score = 85.9 bits (211), Expect = 4e-17
Identities = 71/292 (24%), Positives = 125/292 (42%), Gaps = 20/292 (6%)
Query: 21 TLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRT 80
T+ H + + G G S L PLDL+K R + + G+L L + +
Sbjct: 16 TVFRHVRYENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKL 75
Query: 81 ESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPP--TALESVMLGVGSRSVAG 138
+ L GL++G++P+I G+YF ++K Y G A E ++ + ++
Sbjct: 76 DGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTL 135
Query: 139 VCMSPITVIKTR--------YESGKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAP 190
+P+ V KTR S Y+ ++ L IY EG RGL+ G L +
Sbjct: 136 CITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGTSH 195
Query: 191 FSGIYLMF------YNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTH 244
+ ++ + YNQ N +P +A L + S + I A T P V++
Sbjct: 196 GALQFMAYELLKLKYNQHINRLP----EAQLSTVEYISVAALSKIFAVAATYPYQVVRAR 251
Query: 245 MQLYPLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEM 296
+Q + + + +T ++ G+ GF++G P +R T + + VYE +
Sbjct: 252 LQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENV 303
Score = 45.4 bits (106), Expect = 6e-05
Identities = 41/179 (22%), Positives = 70/179 (39%), Gaps = 10/179 (5%)
Query: 37 SGTCSTLLFQPLDLLKTRLQ----TLQPSDHGSRRVGMLAVLLKVVRTESLLGLWKGMSP 92
+G + + PL + KTRL + S H + GM L+K+ + E + GL+KG P
Sbjct: 130 AGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYK-GMFDTLVKIYKYEGVRGLYKGFVP 188
Query: 93 SIVRCVPGVGIYFG-TLYSLKQYFLRGHPPTA----LESVMLGVGSRSVAGVCMSPITVI 147
+ G + L LK P A +E + + S+ A P V+
Sbjct: 189 GLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVV 248
Query: 148 KTRYESGKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTKNIV 206
+ R + Y + + + EG G + G+ L+R P I + Y + +
Sbjct: 249 RARLQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFL 307
>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
sapiens]
Length = 477
Score = 85.9 bits (211), Expect = 4e-17
Identities = 68/285 (23%), Positives = 121/285 (42%), Gaps = 17/285 (5%)
Query: 29 KAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSR--RVGMLAVLLKVVRTESLLGL 86
+ L G I+G S PLD LK +Q HGS+ ++ + ++V+ + L
Sbjct: 196 RQLLAGGIAGAVSRTSTAPLDRLKIMMQV-----HGSKSDKMNIFGGFRQMVKEGGIRSL 250
Query: 87 WKGMSPSIVRCVPGVGIYFGTLYSLKQYFLR-GHPPTALESVMLGVGSRSVAGVCMSPIT 145
W+G ++++ P + F K+ G E + G + + A + P+
Sbjct: 251 WRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPME 310
Query: 146 VIKTRYESGKYG-YESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTKN 204
V+KTR GK G Y IY + I EG + G LL P++GI L Y K+
Sbjct: 311 VMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKS 370
Query: 205 IVPHDQVDATLIP--ITNFSCGIFAGILASLVTQPADVIKTHMQLYPL-----KFQWIGQ 257
+ ++ P + CG + L + P +++T MQ + + +G
Sbjct: 371 YWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGL 430
Query: 258 AVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEMMAKMGL 302
+I K+ G+ G ++G P ++ +++ VYE M +G+
Sbjct: 431 FRRIISKE-GIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGV 474
>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
sapiens]
Length = 458
Score = 85.9 bits (211), Expect = 4e-17
Identities = 68/285 (23%), Positives = 121/285 (42%), Gaps = 17/285 (5%)
Query: 29 KAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSR--RVGMLAVLLKVVRTESLLGL 86
+ L G I+G S PLD LK +Q HGS+ ++ + ++V+ + L
Sbjct: 177 RQLLAGGIAGAVSRTSTAPLDRLKIMMQV-----HGSKSDKMNIFGGFRQMVKEGGIRSL 231
Query: 87 WKGMSPSIVRCVPGVGIYFGTLYSLKQYFLR-GHPPTALESVMLGVGSRSVAGVCMSPIT 145
W+G ++++ P + F K+ G E + G + + A + P+
Sbjct: 232 WRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPME 291
Query: 146 VIKTRYESGKYG-YESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTKN 204
V+KTR GK G Y IY + I EG + G LL P++GI L Y K+
Sbjct: 292 VMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKS 351
Query: 205 IVPHDQVDATLIP--ITNFSCGIFAGILASLVTQPADVIKTHMQLYPL-----KFQWIGQ 257
+ ++ P + CG + L + P +++T MQ + + +G
Sbjct: 352 YWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGL 411
Query: 258 AVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEMMAKMGL 302
+I K+ G+ G ++G P ++ +++ VYE M +G+
Sbjct: 412 FRRIISKE-GIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGV 455
>gi|116235466 solute carrier family 25, member 45 isoform b [Homo
sapiens]
Length = 246
Score = 84.3 bits (207), Expect = 1e-16
Identities = 74/249 (29%), Positives = 111/249 (44%), Gaps = 24/249 (9%)
Query: 74 LLKVVRTESLLGLWKGMSPSI--VRCVPGV--GIYFGTLYSL---KQYFLRGHPPTALES 126
++K+ R ESLLG +KGMS I + V V G+Y TL L R PP+ +
Sbjct: 1 MVKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHI 60
Query: 127 VMLGVGSRSVAGVCMSPITVIKTRYE----------SGKYGYESIYAALRSIYHSEGHRG 176
+ G + C++P +IK R + S Y+ SI+ EG RG
Sbjct: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
Query: 177 LFSGLTATLLRDAPFSGIYLMFY-NQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVT 235
LF G A LRD P GIY + Y + P Q ++ T G FAGI + +
Sbjct: 121 LFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVAA 177
Query: 236 QPADVIKTHMQLYPLK---FQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTV 292
P D+IK+ MQ+ L+ +Q + + + GL FF+G + R + A+ +
Sbjct: 178 TPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLS 237
Query: 293 YEEMMAKMG 301
YE ++ G
Sbjct: 238 YEYLLRWWG 246
Score = 62.0 bits (149), Expect = 6e-10
Identities = 49/178 (27%), Positives = 75/178 (42%), Gaps = 9/178 (5%)
Query: 31 FLCGSISGTCSTLLFQPLDLLKTRLQT-----LQPSDHGSRRVGMLAVLLKVVRTESLLG 85
FL G G P DL+K RLQ QP R G + + R E G
Sbjct: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
Query: 86 LWKGMSPSIVRCVPGVGIYFGTLYSL-KQYFLRGHPPTALESVMLGVGSRSVAGVCMSPI 144
L++G +R P VGIYF T L +QY G P++ ++ G + + V +P+
Sbjct: 121 LFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPL 180
Query: 145 TVIKTRYESG---KYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFY 199
+IK+R + + Y+ + + S EG F G+T R P + + + Y
Sbjct: 181 DMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSY 238
>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
Length = 468
Score = 84.3 bits (207), Expect = 1e-16
Identities = 72/290 (24%), Positives = 126/290 (43%), Gaps = 23/290 (7%)
Query: 29 KAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSR--RVGMLAVLLKVVRTESLLGL 86
K + G+++G S PLD LK +Q H S+ R+ +L L +V + L
Sbjct: 187 KQLVAGAVAGAVSRTGTAPLDRLKVFMQV-----HASKTNRLNILGGLRSMVLEGGIRSL 241
Query: 87 WKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPT--ALESVMLGVGSRSVAGVCMSPI 144
W+G ++++ P I F +K+ L G T E + G + + A + P+
Sbjct: 242 WRGNGINVLKIAPESAIKFMAYEQIKRAIL-GQQETLHVQERFVAGSLAGATAQTIIYPM 300
Query: 145 TVIKTRYESGKYG-YESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTK 203
V+KTR + G Y+ + R I EG R + G +L P++GI L Y K
Sbjct: 301 EVLKTRLTLRRTGQYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDLAVYETLK 360
Query: 204 NI----VPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQLYPL-----KFQW 254
N HD D ++ + +CG + + + P +++T MQ +
Sbjct: 361 NWWLQQYSHDSADPGILVL--LACGTISSTCGQIASYPLALVRTRMQAQASIEGGPQLSM 418
Query: 255 IGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEMMAKMGLKS 304
+G + I G+RG ++G P ++ ++++ VYE M +G+ S
Sbjct: 419 LG-LLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYENMKQALGVTS 467
Score = 62.8 bits (151), Expect = 4e-10
Identities = 45/186 (24%), Positives = 87/186 (46%), Gaps = 13/186 (6%)
Query: 27 VIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGL 86
V + F+ GS++G + + P+++LKTRL + + G+L +++ E
Sbjct: 279 VQERFVAGSLAGATAQTIIYPMEVLKTRLTLRRTGQY----KGLLDCARRILEREGPRAF 334
Query: 87 WKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGH-----PPTALESVMLGVGSRSVAGVCM 141
++G P+++ +P GI +LK ++L+ + P L + G S + +
Sbjct: 335 YRGYLPNVLGIIPYAGIDLAVYETLKNWWLQQYSHDSADPGILVLLACGTISSTCGQIAS 394
Query: 142 SPITVIKTRYE---SGKYGYE-SIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLM 197
P+ +++TR + S + G + S+ LR I EG RGL+ G+ ++ P I +
Sbjct: 395 YPLALVRTRMQAQASIEGGPQLSMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYV 454
Query: 198 FYNQTK 203
Y K
Sbjct: 455 VYENMK 460
Score = 60.1 bits (144), Expect = 2e-09
Identities = 28/87 (32%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
Query: 27 VIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGL 86
++ CG+IS TC + PL L++TR+Q Q S G ++ ML +L ++ E + GL
Sbjct: 376 ILVLLACGTISSTCGQIASYPLALVRTRMQA-QASIEGGPQLSMLGLLRHILSQEGMRGL 434
Query: 87 WKGMSPSIVRCVPGVGIYFGTLYSLKQ 113
++G++P+ ++ +P V I + ++KQ
Sbjct: 435 YRGIAPNFMKVIPAVSISYVVYENMKQ 461
>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
sapiens]
Length = 676
Score = 83.2 bits (204), Expect = 3e-16
Identities = 78/299 (26%), Positives = 129/299 (43%), Gaps = 22/299 (7%)
Query: 11 QPQDVGDTVETLMLHPVIKA--FLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRV 68
Q + GD+ ++L A F GS++G P+DL+KTR+Q + + V
Sbjct: 311 QQKASGDSARPVLLQVAESAYRFGLGSVAGAVGATAVYPIDLVKTRMQNQRST---GSFV 367
Query: 69 GMLAV------LLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLR--GHP 120
G L KV+R E GL++G+ P ++ P I ++ F+ G
Sbjct: 368 GELMYKNSFDCFKKVLRYEGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSV 427
Query: 121 PTALESVMLGVGSRSVAGVCMSPITVIKTRYE-SGKYGYESIYAALRSIYHSEGHRGLFS 179
P A E + G S + +P+ ++K R + +G+ +AL S+ G G++
Sbjct: 428 PLAAEILAGGCAGGSQV-IFTNPLEIVKIRLQVAGEITTGPRVSAL-SVVRDLGFFGIYK 485
Query: 180 GLTATLLRDAPFSGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPAD 239
G A LRD PFS IY Y K ++ D + P + G AG+ A+ + PAD
Sbjct: 486 GAKACFLRDIPFSAIYFPCYAHVKASFANE--DGQVSPGSLLLAGAIAGMPAASLVTPAD 543
Query: 240 VIKTHMQLY----PLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYE 294
VIKT +Q+ + + I ++ G + ++G R R + + YE
Sbjct: 544 VIKTRLQVAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYE 602
>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
sapiens]
Length = 675
Score = 82.8 bits (203), Expect = 3e-16
Identities = 77/294 (26%), Positives = 127/294 (43%), Gaps = 22/294 (7%)
Query: 16 GDTVETLMLHPVIKA--FLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAV 73
GD+ ++L A F GS++G P+DL+KTR+Q + + VG L
Sbjct: 315 GDSARPVLLQVAESAYRFGLGSVAGAVGATAVYPIDLVKTRMQNQRST---GSFVGELMY 371
Query: 74 ------LLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLR--GHPPTALE 125
KV+R E GL++G+ P ++ P I ++ F+ G P A E
Sbjct: 372 KNSFDCFKKVLRYEGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAE 431
Query: 126 SVMLGVGSRSVAGVCMSPITVIKTRYE-SGKYGYESIYAALRSIYHSEGHRGLFSGLTAT 184
+ G S + +P+ ++K R + +G+ +AL S+ G G++ G A
Sbjct: 432 ILAGGCAGGSQV-IFTNPLEIVKIRLQVAGEITTGPRVSAL-SVVRDLGFFGIYKGAKAC 489
Query: 185 LLRDAPFSGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTH 244
LRD PFS IY Y K ++ D + P + G AG+ A+ + PADVIKT
Sbjct: 490 FLRDIPFSAIYFPCYAHVKASFANE--DGQVSPGSLLLAGAIAGMPAASLVTPADVIKTR 547
Query: 245 MQLY----PLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYE 294
+Q+ + + I ++ G + ++G R R + + YE
Sbjct: 548 LQVAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYE 601
>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
Length = 678
Score = 82.4 bits (202), Expect = 4e-16
Identities = 72/276 (26%), Positives = 120/276 (43%), Gaps = 18/276 (6%)
Query: 31 FLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAV------LLKVVRTESLL 84
F GS++G P+DL+KTR+Q + S VG L KV+R E
Sbjct: 330 FTLGSVAGAVGATAVYPIDLVKTRMQNQRGS---GSVVGELMYKNSFDCFKKVLRYEGFF 386
Query: 85 GLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESVMLGVGSRSVAGVCMS-P 143
GL++G+ P ++ P I ++ F R L + +L G + V + P
Sbjct: 387 GLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTNP 446
Query: 144 ITVIKTRYE-SGKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQT 202
+ ++K R + +G+ +AL ++ G GL+ G A LRD PFS IY Y
Sbjct: 447 LEIVKIRLQVAGEITTGPRVSAL-NVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHC 505
Query: 203 KNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQLY----PLKFQWIGQA 258
K ++ + + + + + G AG+ A+ + PADVIKT +Q+ + +
Sbjct: 506 KLLLADE--NGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVIDC 563
Query: 259 VTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYE 294
I ++ G F++G R R + + YE
Sbjct: 564 FRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYE 599
Score = 61.2 bits (147), Expect = 1e-09
Identities = 49/180 (27%), Positives = 73/180 (40%), Gaps = 12/180 (6%)
Query: 26 PVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLG 85
P+ L G +G + PL+++K RLQ G G L V+R + G
Sbjct: 425 PLPAEVLAGGCAGGSQVIFTNPLEIVKIRLQVA-----GEITTGPRVSALNVLRDLGIFG 479
Query: 86 LWKGMSPSIVRCVPGVGIYFGTLYSLKQYFL--RGHPPTALESVMLGVGSRSVAGVCMSP 143
L+KG +R +P IYF K GH L + G + A ++P
Sbjct: 480 LYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGH-VGGLNLLAAGAMAGVPAASLVTP 538
Query: 144 ITVIKTRYE----SGKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFY 199
VIKTR + +G+ Y + R I EG + G A + R +P G+ L+ Y
Sbjct: 539 ADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTY 598
>gi|20149598 solute carrier family 25 (mitochondrial carrier;
dicarboxylate transporter), member 10 [Homo sapiens]
Length = 287
Score = 81.6 bits (200), Expect = 8e-16
Identities = 75/278 (26%), Positives = 118/278 (42%), Gaps = 19/278 (6%)
Query: 35 SISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGLWKGMSPSI 94
S C T PLDLLK LQT Q ++ M + L+VVRT+ +L L+ G+S S+
Sbjct: 17 SCGAACCT---HPLDLLKVHLQTQQEV-----KLRMTGMALRVVRTDGILALYSGLSASL 68
Query: 95 VRCVPGVGIYFGTLYSLKQYFLRGH--PPTALESVMLGVGSRSVAGVCMSPITVIKTRYE 152
R + F +++ +G P E V+LG S G +P ++ R +
Sbjct: 69 CRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQ 128
Query: 153 SG-------KYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTKNI 205
+ + Y L + EG R LFSG T R A + L Y+Q K +
Sbjct: 129 NDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYDQAKQL 188
Query: 206 VPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQLYPLKFQWIGQAVTLIFKD 265
V + I T+F AG A+ + QP DV+KT + ++Q + K
Sbjct: 189 VLSTGYLSDNI-FTHFVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHCAVETAK- 246
Query: 266 YGLRGFFQGGIPRALRRTLMAAMAWTVYEEMMAKMGLK 303
G F++G +P +R + + E++ G+K
Sbjct: 247 LGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGIK 284
Score = 43.9 bits (102), Expect = 2e-04
Identities = 30/87 (34%), Positives = 43/87 (49%), Gaps = 10/87 (11%)
Query: 31 FLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESL--LGLWK 88
F+ I+G C+T L QPLD+LKTRL + G V V T L L +K
Sbjct: 203 FVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQG--------VFHCAVETAKLGPLAFYK 254
Query: 89 GMSPSIVRCVPGVGIYFGTLYSLKQYF 115
G+ P+ +R +P + F L L++ F
Sbjct: 255 GLVPAGIRLIPHTVLTFVFLEQLRKNF 281
Score = 38.1 bits (87), Expect = 0.010
Identities = 47/188 (25%), Positives = 77/188 (40%), Gaps = 17/188 (9%)
Query: 26 PVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRR--VGMLAVLLKVVRTESL 83
P + L GS+SG + P DL+ R+Q G RR L L +V R E L
Sbjct: 98 PFHEKVLLGSVSGLAGGFVGTPADLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGL 157
Query: 84 LGLWKGMSPSIVRCVPGVGIYFGTLY---SLKQYFLRGHPPTALESVMLGVGSRSVAGVC 140
L+ G + + R G + G L KQ L +++ + +AG C
Sbjct: 158 RRLFSGATMASSR---GALVTVGQLSCYDQAKQLVL--STGYLSDNIFTHFVASFIAGGC 212
Query: 141 MS----PITVIKTRYESGKYGYESIY-AALRSIYHSEGHRGLFSGLTATLLRDAPFSGIY 195
+ P+ V+KTR + K Y+ ++ A+ + G + GL +R P + +
Sbjct: 213 ATFLCQPLDVLKTRLMNSKGEYQGVFHCAVETA--KLGPLAFYKGLVPAGIRLIPHTVLT 270
Query: 196 LMFYNQTK 203
+F Q +
Sbjct: 271 FVFLEQLR 278
>gi|14150082 mitochondrial carrier protein MGC4399 [Homo sapiens]
Length = 321
Score = 78.6 bits (192), Expect = 6e-15
Identities = 77/312 (24%), Positives = 130/312 (41%), Gaps = 39/312 (12%)
Query: 16 GDTVETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQ--------PSDH---- 63
G E +LH G GT + PL+++KTRLQ+ + P H
Sbjct: 5 GQQKENTLLH-----LFAGGCGGTVGAIFTCPLEVIKTRLQSSRLALRTVYYPQVHLGTI 59
Query: 64 -GSRRV-------GMLAVLLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYF 115
G+ V G+ VL ++ E L++G+ P++V P +YF K+ F
Sbjct: 60 SGAGMVRPTSVTPGLFQVLKSILEKEGPKSLFRGLGPNLVGVAPSRAVYFACYSKAKEQF 119
Query: 116 LRGHPPTALESVMLGVGSRS-VAGVCMSPITVIKTRYE-----SGKYGYESIYAALRSIY 169
P + + GS + + M+PI ++KTR + G ++ A R +Y
Sbjct: 120 NGIFVPNSNIVHIFSAGSAAFITNSLMNPIWMVKTRMQLEQKVRGSKQMNTLQCA-RYVY 178
Query: 170 HSEGHRGLFSGLTAT---LLRDAPFSGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIF 226
+EG RG + GLTA+ + IY K + T T+F +
Sbjct: 179 QTEGIRGFYRGLTASYAGISETIICFAIYESLKKYLKEAPLASSANGTEKNSTSFFGLMA 238
Query: 227 AGIL----ASLVTQPADVIKTHMQLYPLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRR 282
A L AS + P +VI+T ++ K++ Q L+F++ G F++G + +R+
Sbjct: 239 AAALSKGCASCIAYPHEVIRTRLREEGTKYKSFVQTARLVFREEGYLAFYRGLFAQLIRQ 298
Query: 283 TLMAAMAWTVYE 294
A+ + YE
Sbjct: 299 IPNTAIVLSTYE 310
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.139 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,817,561
Number of Sequences: 37866
Number of extensions: 446240
Number of successful extensions: 1454
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 940
Number of HSP's gapped (non-prelim): 191
length of query: 304
length of database: 18,247,518
effective HSP length: 102
effective length of query: 202
effective length of database: 14,385,186
effective search space: 2905807572
effective search space used: 2905807572
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.