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Search of human proteins with 156713430
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156713430 doublecortin-like kinase 2 isoform b [Homo
sapiens]
(765 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 1535 0.0
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 1531 0.0
gi|4758128 doublecortin-like kinase 1 [Homo sapiens] 959 0.0
gi|30181244 doublecortin isoform c [Homo sapiens] 473 e-133
gi|30181240 doublecortin isoform c [Homo sapiens] 473 e-133
gi|30181246 doublecortin isoform a [Homo sapiens] 473 e-133
gi|30181242 doublecortin isoform b [Homo sapiens] 469 e-132
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 313 4e-85
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 260 4e-69
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 247 3e-65
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 247 3e-65
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 245 1e-64
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 243 6e-64
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 234 2e-61
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 227 4e-59
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 226 8e-59
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 226 8e-59
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 225 1e-58
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 225 1e-58
gi|26051210 calcium/calmodulin-dependent protein kinase II beta ... 225 1e-58
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 224 2e-58
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 224 2e-58
gi|26051208 calcium/calmodulin-dependent protein kinase II beta ... 223 5e-58
gi|26051204 calcium/calmodulin-dependent protein kinase II beta ... 223 7e-58
gi|26051214 calcium/calmodulin-dependent protein kinase II beta ... 223 7e-58
gi|26051206 calcium/calmodulin-dependent protein kinase II beta ... 223 7e-58
gi|26051218 calcium/calmodulin-dependent protein kinase II beta ... 223 7e-58
gi|26051216 calcium/calmodulin-dependent protein kinase II beta ... 222 9e-58
gi|26051212 calcium/calmodulin-dependent protein kinase II beta ... 222 9e-58
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 220 3e-57
>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
Length = 765
Score = 1535 bits (3975), Expect = 0.0
Identities = 765/765 (100%), Positives = 765/765 (100%)
Query: 1 MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTR 60
MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTR
Sbjct: 1 MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTR 60
Query: 61 TLQALSSEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGV 120
TLQALSSEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGV
Sbjct: 61 TLQALSSEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGV 120
Query: 121 RTIYTIDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRALAAA 180
RTIYTIDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRALAAA
Sbjct: 121 RTIYTIDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRALAAA 180
Query: 181 SSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSG 240
SSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSG
Sbjct: 181 SSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSG 240
Query: 241 VVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSA 300
VVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSA
Sbjct: 241 VVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSA 300
Query: 301 VKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKISAHGRSS 360
VKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKISAHGRSS
Sbjct: 301 VKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKISAHGRSS 360
Query: 361 SNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFA 420
SNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFA
Sbjct: 361 SNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFA 420
Query: 421 LKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAI 480
LKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAI
Sbjct: 421 LKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAI 480
Query: 481 TSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLA 540
TSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLA
Sbjct: 481 TSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLA 540
Query: 541 TVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDL 600
TVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDL
Sbjct: 541 TVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDL 600
Query: 601 FDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNM 660
FDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNM
Sbjct: 601 FDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNM 660
Query: 661 QAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPGMEPISPV 720
QAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPGMEPISPV
Sbjct: 661 QAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPGMEPISPV 720
Query: 721 PPSVEEIPVPGEAVPAPTPPESPTPHPPPAAPGGERAGTWRRHRD 765
PPSVEEIPVPGEAVPAPTPPESPTPHPPPAAPGGERAGTWRRHRD
Sbjct: 721 PPSVEEIPVPGEAVPAPTPPESPTPHPPPAAPGGERAGTWRRHRD 765
>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
Length = 766
Score = 1531 bits (3963), Expect = 0.0
Identities = 765/766 (99%), Positives = 765/766 (99%), Gaps = 1/766 (0%)
Query: 1 MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTR 60
MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTR
Sbjct: 1 MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTR 60
Query: 61 TLQALSSEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGV 120
TLQALSSEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGV
Sbjct: 61 TLQALSSEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGV 120
Query: 121 RTIYTIDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRALAAA 180
RTIYTIDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRALAAA
Sbjct: 121 RTIYTIDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRALAAA 180
Query: 181 SSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSG 240
SSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSG
Sbjct: 181 SSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSG 240
Query: 241 VVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSA 300
VVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSA
Sbjct: 241 VVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSA 300
Query: 301 VKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLK-ISAHGRS 359
VKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLK ISAHGRS
Sbjct: 301 VKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAHGRS 360
Query: 360 SSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEF 419
SSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEF
Sbjct: 361 SSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEF 420
Query: 420 ALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDA 479
ALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDA
Sbjct: 421 ALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDA 480
Query: 480 ITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGL 539
ITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGL
Sbjct: 481 ITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGL 540
Query: 540 ATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQED 599
ATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQED
Sbjct: 541 ATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQED 600
Query: 600 LFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENN 659
LFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENN
Sbjct: 601 LFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENN 660
Query: 660 MQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPGMEPISP 719
MQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPGMEPISP
Sbjct: 661 MQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPGMEPISP 720
Query: 720 VPPSVEEIPVPGEAVPAPTPPESPTPHPPPAAPGGERAGTWRRHRD 765
VPPSVEEIPVPGEAVPAPTPPESPTPHPPPAAPGGERAGTWRRHRD
Sbjct: 721 VPPSVEEIPVPGEAVPAPTPPESPTPHPPPAAPGGERAGTWRRHRD 766
>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
Length = 729
Score = 959 bits (2479), Expect = 0.0
Identities = 502/733 (68%), Positives = 589/733 (80%), Gaps = 35/733 (4%)
Query: 1 MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTR 60
M+ R +ELEHF+ERDK R S G + NGL PSP HSAHCSFYRTR
Sbjct: 1 MSFGRDMELEHFDERDKAQR--------------YSRGSRVNGL-PSPTHSAHCSFYRTR 45
Query: 61 TLQALSSEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGV 120
TLQ LSSEKKAKK RFYRNGDRYFKG+V+AIS DRFRSF+ALL +LTR+LSDNVNLPQGV
Sbjct: 46 TLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGV 105
Query: 121 RTIYTIDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKG-GTSRALAA 179
RTIYTIDG +K++SLD+L+EGESYVC S EPF+K++YTKN+NPNWSVN+K SRA+++
Sbjct: 106 RTIYTIDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSS 165
Query: 180 ASSVK---SEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIK 236
++ K SEV+E+KDFI+PKLVT+IRSGVKPRKAVRILLNKKTAHSFEQVLTDIT+AIK
Sbjct: 166 LATAKGSPSEVRENKDFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIK 225
Query: 237 LDSGVVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKS-SY 295
LDSGVVKRL TLDGKQV CLQDFFGDDD+FIACGPEKFRY QDDF+LD SECRV+KS SY
Sbjct: 226 LDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRY-QDDFLLDESECRVVKSTSY 284
Query: 296 SR-SSAVKYSGSKSPGPSRRSKSPAS---VNGTPSSQLSTPKSTKSSSSSPTSPGSFRGL 351
++ +S+ + S +KSPGPSRRSKSPAS VNGTP SQLSTP+S KS S SPTSPGS R
Sbjct: 285 TKIASSSRRSTTKSPGPSRRSKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTSPGSLRKQ 344
Query: 352 KISAHGRSSSNVNGGPELDRCISPEGVNGNRCSES-----STLLEKYKIGKVIGDGNFAV 406
+ S HG SS+++ +G G SE +T+ E+YK+G+ IGDGNFAV
Sbjct: 345 RSSQHGGSSTSLASTKVCSSMDENDGP-GEEVSEEGFQIPATITERYKVGRTIGDGNFAV 403
Query: 407 VKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFL 466
VKEC++RST +E+ALKII K+KC GKEH+I+NEVSILRRVKHPNI++L+EEM+ TEL+L
Sbjct: 404 VKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYL 463
Query: 467 VMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYP 526
VMELVKGGDLFDAITS+ KYTERD S M+YNLA+A++YLH L+IVHRDIKPENLLV E+
Sbjct: 464 VMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQ 523
Query: 527 DGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCG 586
DG+KSLKLGDFGLAT+V+GPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCG
Sbjct: 524 DGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCG 583
Query: 587 FPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILS 646
FPPFR + QE LFDQIL G+++FP+PYWDN++DSAKELI+ ML V+V+ R +A Q+L
Sbjct: 584 FPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLE 643
Query: 647 HPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHC 706
HPWV+DD EN Q V GK+K+HFN PK NST GVSVI ALD I S
Sbjct: 644 HPWVNDDGLPENEHQLSVAGKIKKHFNTG-PKPNSTAAGVSVI---ALDHGFTIKRSGSL 699
Query: 707 QDSGRPGMEPISP 719
+PGM I P
Sbjct: 700 DYYQQPGMYWIRP 712
>gi|30181244 doublecortin isoform c [Homo sapiens]
Length = 360
Score = 473 bits (1216), Expect = e-133
Identities = 244/352 (69%), Positives = 284/352 (80%), Gaps = 24/352 (6%)
Query: 7 IELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTRTLQALS 66
++ HF+ERDK R + G + NGL PSP HSAHCSFYRTRTLQALS
Sbjct: 3 LDFGHFDERDKTSR--------------NMRGSRMNGL-PSPTHSAHCSFYRTRTLQALS 47
Query: 67 SEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGVRTIYTI 126
+EKKAKK RFYRNGDRYFKG+V+A+SSDRFRSFDALL +LTRSLSDN+NLPQGVR IYTI
Sbjct: 48 NEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQGVRYIYTI 107
Query: 127 DGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRAL--AAASSVK 184
DGSRK+ S+DEL EGESYVC+S+ F+KV+YTKN+NPNWSVN+K + + ASS
Sbjct: 108 DGSRKIGSMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTSANMKAPQSLASSNS 167
Query: 185 SEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKR 244
++ +E+KDF++PKLVT+IRSGVKPRKAVR+LLNKKTAHSFEQVLTDITEAIKL++GVVK+
Sbjct: 168 AQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKK 227
Query: 245 LCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYS 304
L TLDGKQVTCL DFFGDDDVFIACGPEKFRYAQDDF LD +ECRV+K + S ++ K S
Sbjct: 228 LYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSATAGPKAS 287
Query: 305 ------GSKSPGPSRRSKSPA-SVNGTPSSQLSTPKSTKSSSSSPTSPGSFR 349
+KSPGP RRSKSPA S NGT SSQLSTPKS +S S+PTSPGS R
Sbjct: 288 PTPQKTSAKSPGPMRRSKSPADSANGTSSSQLSTPKSKQSPISTPTSPGSLR 339
>gi|30181240 doublecortin isoform c [Homo sapiens]
Length = 360
Score = 473 bits (1216), Expect = e-133
Identities = 244/352 (69%), Positives = 284/352 (80%), Gaps = 24/352 (6%)
Query: 7 IELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTRTLQALS 66
++ HF+ERDK R + G + NGL PSP HSAHCSFYRTRTLQALS
Sbjct: 3 LDFGHFDERDKTSR--------------NMRGSRMNGL-PSPTHSAHCSFYRTRTLQALS 47
Query: 67 SEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGVRTIYTI 126
+EKKAKK RFYRNGDRYFKG+V+A+SSDRFRSFDALL +LTRSLSDN+NLPQGVR IYTI
Sbjct: 48 NEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQGVRYIYTI 107
Query: 127 DGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRAL--AAASSVK 184
DGSRK+ S+DEL EGESYVC+S+ F+KV+YTKN+NPNWSVN+K + + ASS
Sbjct: 108 DGSRKIGSMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTSANMKAPQSLASSNS 167
Query: 185 SEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKR 244
++ +E+KDF++PKLVT+IRSGVKPRKAVR+LLNKKTAHSFEQVLTDITEAIKL++GVVK+
Sbjct: 168 AQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKK 227
Query: 245 LCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYS 304
L TLDGKQVTCL DFFGDDDVFIACGPEKFRYAQDDF LD +ECRV+K + S ++ K S
Sbjct: 228 LYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSATAGPKAS 287
Query: 305 ------GSKSPGPSRRSKSPA-SVNGTPSSQLSTPKSTKSSSSSPTSPGSFR 349
+KSPGP RRSKSPA S NGT SSQLSTPKS +S S+PTSPGS R
Sbjct: 288 PTPQKTSAKSPGPMRRSKSPADSANGTSSSQLSTPKSKQSPISTPTSPGSLR 339
>gi|30181246 doublecortin isoform a [Homo sapiens]
Length = 441
Score = 473 bits (1216), Expect = e-133
Identities = 244/352 (69%), Positives = 284/352 (80%), Gaps = 24/352 (6%)
Query: 7 IELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTRTLQALS 66
++ HF+ERDK R + G + NGL PSP HSAHCSFYRTRTLQALS
Sbjct: 84 LDFGHFDERDKTSR--------------NMRGSRMNGL-PSPTHSAHCSFYRTRTLQALS 128
Query: 67 SEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGVRTIYTI 126
+EKKAKK RFYRNGDRYFKG+V+A+SSDRFRSFDALL +LTRSLSDN+NLPQGVR IYTI
Sbjct: 129 NEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQGVRYIYTI 188
Query: 127 DGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRAL--AAASSVK 184
DGSRK+ S+DEL EGESYVC+S+ F+KV+YTKN+NPNWSVN+K + + ASS
Sbjct: 189 DGSRKIGSMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTSANMKAPQSLASSNS 248
Query: 185 SEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKR 244
++ +E+KDF++PKLVT+IRSGVKPRKAVR+LLNKKTAHSFEQVLTDITEAIKL++GVVK+
Sbjct: 249 AQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKK 308
Query: 245 LCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYS 304
L TLDGKQVTCL DFFGDDDVFIACGPEKFRYAQDDF LD +ECRV+K + S ++ K S
Sbjct: 309 LYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSATAGPKAS 368
Query: 305 ------GSKSPGPSRRSKSPA-SVNGTPSSQLSTPKSTKSSSSSPTSPGSFR 349
+KSPGP RRSKSPA S NGT SSQLSTPKS +S S+PTSPGS R
Sbjct: 369 PTPQKTSAKSPGPMRRSKSPADSANGTSSSQLSTPKSKQSPISTPTSPGSLR 420
>gi|30181242 doublecortin isoform b [Homo sapiens]
Length = 365
Score = 469 bits (1207), Expect = e-132
Identities = 243/357 (68%), Positives = 283/357 (79%), Gaps = 29/357 (8%)
Query: 7 IELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTRTLQALS 66
++ HF+ERDK R + G + NGL PSP HSAHCSFYRTRTLQALS
Sbjct: 3 LDFGHFDERDKTSR--------------NMRGSRMNGL-PSPTHSAHCSFYRTRTLQALS 47
Query: 67 SEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGVRTIYTI 126
+EKKAKK RFYRNGDRYFKG+V+A+SSDRFRSFDALL +LTRSLSDN+NLPQGVR IYTI
Sbjct: 48 NEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQGVRYIYTI 107
Query: 127 DGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRAL--AAASSVK 184
DGSRK+ S+DEL EGESYVC+S+ F+KV+YTKN+NPNWSVN+K + + ASS
Sbjct: 108 DGSRKIGSMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTSANMKAPQSLASSNS 167
Query: 185 SEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKR 244
++ +E+KDF++PKLVT+IRSGVKPRKAVR+LLNKKTAHSFEQVLTDITEAIKL++GVVK+
Sbjct: 168 AQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKK 227
Query: 245 LCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYS 304
L TLDGKQVTCL DFFGDDDVFIACGPEKFRYAQDDF LD +ECRV+K + S ++ K S
Sbjct: 228 LYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSATAGPKAS 287
Query: 305 ------GSKSPGPSRRSKSPA------SVNGTPSSQLSTPKSTKSSSSSPTSPGSFR 349
+KSPGP RRSKSPA NGT SSQLSTPKS +S S+PTSPGS R
Sbjct: 288 PTPQKTSAKSPGPMRRSKSPADSGNDQDANGTSSSQLSTPKSKQSPISTPTSPGSLR 344
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 313 bits (802), Expect = 4e-85
Identities = 159/311 (51%), Positives = 219/311 (70%), Gaps = 4/311 (1%)
Query: 367 PELDRCISPEGVNGNRCSESSTLLEK-YKIGKVIGDGNFAVVKECIDRSTGKEFALKIID 425
PE ++ P G + +EK Y+ G+VIGDGNFAVVKEC R T + +A+KIID
Sbjct: 329 PEENKPERPSGRKPRPMGIIAANVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIID 388
Query: 426 KAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTK 485
K++ GKE ++++E+ I++ + HPNI+ L E ET E++L++E V+GGDLFDAI S K
Sbjct: 389 KSRLKGKEDMVDSEILIIQSLSHPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVK 448
Query: 486 YTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG 545
+ E D + M+ +L AL ++H SIVHRD+KPENLLV D + +LKL DFGLA V
Sbjct: 449 FPEPDAALMIMDLCKALVHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVR 508
Query: 546 PLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQIL 605
P++TVCGTPTYVAPEI++E GYGL+VD+WAAGVI YILLCGFPPFRS Q++LF+ I
Sbjct: 509 PIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQ 568
Query: 606 AGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNM--QAE 663
G EF PYWDNI+D+AK+L+S++L V+ + R TA Q+L HPW+ + A + N + Q +
Sbjct: 569 LGHFEFLPPYWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQHPWI-ETAGKTNTVKRQKQ 627
Query: 664 VTGKLKQHFNN 674
V+ + HF +
Sbjct: 628 VSPSSEGHFRS 638
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 260 bits (664), Expect = 4e-69
Identities = 135/329 (41%), Positives = 204/329 (62%), Gaps = 10/329 (3%)
Query: 378 VNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIE 437
V G R ++ + + Y V+G G F+ V D+ T K A+K I K GKE +E
Sbjct: 5 VEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSME 64
Query: 438 NEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYN 497
NE+++L ++KHPNI+ L + E+ L+L+M+LV GG+LFD I YTERD S +++
Sbjct: 65 NEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQ 124
Query: 498 LANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVE--GPLYTVCGTPT 555
+ +A++YLH L IVHRD+KPENLL + +K + + DFGL+ + + L T CGTP
Sbjct: 125 VLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSK-IMISDFGLSKMEDPGSVLSTACGTPG 183
Query: 556 YVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPY 615
YVAPE++A+ Y VD W+ GVI YILLCG+PPF EN+ + LF+QIL + EF +PY
Sbjct: 184 YVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAK--LFEQILKAEYEFDSPY 241
Query: 616 WDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNA 675
WD+I+DSAK+ I +++ + E R T Q L HPW++ D + + N+ V+ ++K++F +
Sbjct: 242 WDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKS 301
Query: 676 LPKQNSTTTGV-----SVIMNTALDKEGQ 699
KQ T V + + T+ + +GQ
Sbjct: 302 KWKQAFNATAVVRHMRKLQLGTSQEGQGQ 330
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 247 bits (630), Expect = 3e-65
Identities = 125/297 (42%), Positives = 188/297 (63%), Gaps = 7/297 (2%)
Query: 393 YKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNII 452
++ + +G G F+ V +++TGK FA+K I K GKE IENE+++LR++KH NI+
Sbjct: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 82
Query: 453 MLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVH 512
L + E+ L+LVM+LV GG+LFD I YTE+D S ++ + +A+ YLH + IVH
Sbjct: 83 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVH 142
Query: 513 RDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGP---LYTVCGTPTYVAPEIIAETGYGL 569
RD+KPENLL + +K + + DFGL+ +EG + T CGTP YVAPE++A+ Y
Sbjct: 143 RDLKPENLLYYSQDEESK-IMISDFGLSK-MEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
Query: 570 KVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQ 629
VD W+ GVI YILLCG+PPF EN+ LF+QIL + EF +PYWD+I+DSAK+ I
Sbjct: 201 AVDCWSIGVIAYILLCGYPPFYDEND--SKLFEQILKAEYEFDSPYWDDISDSAKDFIRN 258
Query: 630 MLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGV 686
+++ + R T Q HPW++ D + N+ V+ +++++F + +Q T V
Sbjct: 259 LMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAV 315
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 247 bits (630), Expect = 3e-65
Identities = 125/297 (42%), Positives = 188/297 (63%), Gaps = 7/297 (2%)
Query: 393 YKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNII 452
++ + +G G F+ V +++TGK FA+K I K GKE IENE+++LR++KH NI+
Sbjct: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 82
Query: 453 MLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVH 512
L + E+ L+LVM+LV GG+LFD I YTE+D S ++ + +A+ YLH + IVH
Sbjct: 83 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVH 142
Query: 513 RDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGP---LYTVCGTPTYVAPEIIAETGYGL 569
RD+KPENLL + +K + + DFGL+ +EG + T CGTP YVAPE++A+ Y
Sbjct: 143 RDLKPENLLYYSQDEESK-IMISDFGLSK-MEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
Query: 570 KVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQ 629
VD W+ GVI YILLCG+PPF EN+ LF+QIL + EF +PYWD+I+DSAK+ I
Sbjct: 201 AVDCWSIGVIAYILLCGYPPFYDEND--SKLFEQILKAEYEFDSPYWDDISDSAKDFIRN 258
Query: 630 MLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGV 686
+++ + R T Q HPW++ D + N+ V+ +++++F + +Q T V
Sbjct: 259 LMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAV 315
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 245 bits (626), Expect = 1e-64
Identities = 131/305 (42%), Positives = 189/305 (61%), Gaps = 12/305 (3%)
Query: 377 GVNGNRCSESSTLLEK--------YKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAK 428
G+ G R S LL+K Y+I + +G G F+ V +R + ALK I K
Sbjct: 8 GLAGRRPSGDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKA 67
Query: 429 CCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTE 488
GKE L+ENE+++LRR+ HPNI+ L + E+ + L+L MELV GG+LFD I YTE
Sbjct: 68 LRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTE 127
Query: 489 RDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG-PL 547
+D S +V + A+ YLH L IVHRD+KPENLL P + + DFGL+ + G L
Sbjct: 128 KDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYAT-PFEDSKIMVSDFGLSKIQAGNML 186
Query: 548 YTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAG 607
T CGTP YVAPE++ + YG VD+WA GVI+YILLCG+PPF E++ +LF QIL
Sbjct: 187 GTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESD--PELFSQILRA 244
Query: 608 KLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGK 667
EF +P+WD+I++SAK+ I +L+ + + R T Q L H W+S D + + ++ V+ +
Sbjct: 245 SYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQ 304
Query: 668 LKQHF 672
++++F
Sbjct: 305 IRKNF 309
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 243 bits (619), Expect = 6e-64
Identities = 132/326 (40%), Positives = 195/326 (59%), Gaps = 6/326 (1%)
Query: 350 GLKISAHGRSSSNVNGGPELDRCISPEGVNGNRCSESST--LLEKYKIGKVIGDGNFAVV 407
G ++ R+SS + GG I + + T + Y+I + +G G F+ V
Sbjct: 53 GPQLREAARASSGLGGGGRHPSRIPAIALQDMLLLKKHTEDISSVYEIRERLGSGAFSEV 112
Query: 408 KECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLV 467
+R + ALK I K GKE L+ENE+++LRR+ HPNI+ L + E+ + L+L
Sbjct: 113 VLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLA 172
Query: 468 MELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPD 527
MELV GG+LFD I YTE+D S +V + A+ YLH L IVHRD+KPENLL P
Sbjct: 173 MELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYAT-PF 231
Query: 528 GTKSLKLGDFGLATVVEG-PLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCG 586
+ + DFGL+ + G L T CGTP YVAPE++ + YG VD+WA GVI+YILLCG
Sbjct: 232 EDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCG 291
Query: 587 FPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILS 646
+PPF E++ +LF QIL EF +P+WD+I++SAK+ I +L+ + + R T Q L
Sbjct: 292 YPPFYDESD--PELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALR 349
Query: 647 HPWVSDDASQENNMQAEVTGKLKQHF 672
H W+S D + + ++ V+ +++++F
Sbjct: 350 HLWISGDTAFDRDILGSVSEQIRKNF 375
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 234 bits (598), Expect = 2e-61
Identities = 135/377 (35%), Positives = 214/377 (56%), Gaps = 12/377 (3%)
Query: 385 ESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILR 444
+++ + + + +V+G G F+ V R TGK FALK I K+ ++ +ENE+++L+
Sbjct: 15 QTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAF-RDSSLENEIAVLK 73
Query: 445 RVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRY 504
++KH NI+ L + E+ T +LVM+LV GG+LFD I YTE+D S ++ + +A++Y
Sbjct: 74 KIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKY 133
Query: 505 LHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVE-GPLYTVCGTPTYVAPEIIA 563
LH IVHRD+KPENLL P+ + + DFGL+ + + G + T CGTP YVAPE++A
Sbjct: 134 LHENGIVHRDLKPENLLYLT-PEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLA 192
Query: 564 ETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSA 623
+ Y VD W+ GVITYILLCG+PPF E + LF++I G EF +P+WD+I++SA
Sbjct: 193 QKPYSKAVDCWSIGVITYILLCGYPPFYEET--ESKLFEKIKEGYYEFESPFWDDISESA 250
Query: 624 KELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTT 683
K+ I +L+ + R T + LSHPW+ + + ++ V+ +++++F + +Q
Sbjct: 251 KDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFAKSKWRQAFNA 310
Query: 684 TGV-----SVIMNTALDKEGQIFCSKHCQDSGRPGMEPISPVPPSVEEIPVPGEAVPAPT 738
V + MN ++ + P SP ++ E PV +V P
Sbjct: 311 AAVVHHMRKLHMNLHSPGVRPEVENRPPETQASETSRPSSP-EITITEAPVLDHSVALPA 369
Query: 739 PPESPTPH-PPPAAPGG 754
+ P H P APGG
Sbjct: 370 LTQLPCQHGRRPTAPGG 386
>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
isoform 2 [Homo sapiens]
Length = 527
Score = 227 bits (578), Expect = 4e-59
Identities = 123/327 (37%), Positives = 190/327 (58%), Gaps = 7/327 (2%)
Query: 391 EKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHL-IENEVSILRRVKHP 449
+ Y++ + +G G F+VV+ C+ +++ +E+A KII+ K ++H +E E I R +KHP
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 450 NIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLS 509
NI+ L + + +LV +LV GG+LF+ I + Y+E D S ++ + ++ ++H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHD 131
Query: 510 IVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETG 566
IVHRD+KPENLL+ G ++KL DFGLA V+G + GTP Y++PE++ +
Sbjct: 132 IVHRDLKPENLLLASKCKGA-AVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDP 190
Query: 567 YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL 626
YG VDIWA GVI YILL G+PPF E+ Q L+ QI AG +FP+P WD +T AK L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDED--QHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 627 ISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGV 686
I+QML +N R TA Q L HPWV ++ + M + T + + FN + + T +
Sbjct: 249 INQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTM 308
Query: 687 SVIMNTALDKEGQIFCSKHCQDSGRPG 713
V N ++ ++ S +G G
Sbjct: 309 LVSRNFSVGRQSSAPASPAASAAGLAG 335
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 226 bits (575), Expect = 8e-59
Identities = 120/312 (38%), Positives = 183/312 (58%), Gaps = 7/312 (2%)
Query: 391 EKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHL-IENEVSILRRVKHP 449
E+Y++ + +G G F+VV+ C+ G+E+A KII+ K ++H +E E I R +KHP
Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 70
Query: 450 NIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLS 509
NI+ L + + +L+ +LV GG+LF+ I + Y+E D S + + A+ + H +
Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 130
Query: 510 IVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETG 566
+VHRD+KPENLL+ G ++KL DFGLA VEG + GTP Y++PE++ +
Sbjct: 131 VVHRDLKPENLLLASKLKGA-AVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 189
Query: 567 YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL 626
YG VD+WA GVI YILL G+PPF E+ Q L+ QI AG +FP+P WD +T AK+L
Sbjct: 190 YGKPVDLWACGVILYILLVGYPPFWDED--QHRLYQQIKAGAYDFPSPEWDTVTPEAKDL 247
Query: 627 ISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGV 686
I++ML +N R TA + L HPW+S ++ + M + T + FN + + T +
Sbjct: 248 INKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTM 307
Query: 687 SVIMNTALDKEG 698
N + K G
Sbjct: 308 LATRNFSGGKSG 319
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 226 bits (575), Expect = 8e-59
Identities = 120/312 (38%), Positives = 183/312 (58%), Gaps = 7/312 (2%)
Query: 391 EKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHL-IENEVSILRRVKHP 449
E+Y++ + +G G F+VV+ C+ G+E+A KII+ K ++H +E E I R +KHP
Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 70
Query: 450 NIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLS 509
NI+ L + + +L+ +LV GG+LF+ I + Y+E D S + + A+ + H +
Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 130
Query: 510 IVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETG 566
+VHRD+KPENLL+ G ++KL DFGLA VEG + GTP Y++PE++ +
Sbjct: 131 VVHRDLKPENLLLASKLKGA-AVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 189
Query: 567 YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL 626
YG VD+WA GVI YILL G+PPF E+ Q L+ QI AG +FP+P WD +T AK+L
Sbjct: 190 YGKPVDLWACGVILYILLVGYPPFWDED--QHRLYQQIKAGAYDFPSPEWDTVTPEAKDL 247
Query: 627 ISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGV 686
I++ML +N R TA + L HPW+S ++ + M + T + FN + + T +
Sbjct: 248 INKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTM 307
Query: 687 SVIMNTALDKEG 698
N + K G
Sbjct: 308 LATRNFSGGKSG 319
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 225 bits (573), Expect = 1e-58
Identities = 131/359 (36%), Positives = 199/359 (55%), Gaps = 11/359 (3%)
Query: 391 EKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHL-IENEVSILRRVKHP 449
+ Y++ + +G G F+VV+ C+ +++ +E+A KII+ K ++H +E E I R +KHP
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 450 NIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLS 509
NI+ L + + +LV +LV GG+LF+ I + Y+E D S ++ + ++ ++H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHD 131
Query: 510 IVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETG 566
IVHRD+KPENLL+ G ++KL DFGLA V+G + GTP Y++PE++ +
Sbjct: 132 IVHRDLKPENLLLASKCKGA-AVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDP 190
Query: 567 YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL 626
YG VDIWA GVI YILL G+PPF E+ Q L+ QI AG +FP+P WD +T AK L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDED--QHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 627 ISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGV 686
I+QML +N R TA Q L HPWV ++ + M + T + + FN + + T +
Sbjct: 249 INQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTM 308
Query: 687 SVIMNTALDKEGQIFCSKHCQDSGRP-GMEPISPVPPSVEEIPVPGEAVPAPTPPESPT 744
V N + K +K +P S V P+ E P+ P T + T
Sbjct: 309 LVSRNFSAAKS---LLNKKSDGGVKPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNAT 364
>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
isoform 1 [Homo sapiens]
Length = 556
Score = 225 bits (573), Expect = 1e-58
Identities = 131/359 (36%), Positives = 199/359 (55%), Gaps = 11/359 (3%)
Query: 391 EKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHL-IENEVSILRRVKHP 449
+ Y++ + +G G F+VV+ C+ +++ +E+A KII+ K ++H +E E I R +KHP
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 450 NIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLS 509
NI+ L + + +LV +LV GG+LF+ I + Y+E D S ++ + ++ ++H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHD 131
Query: 510 IVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETG 566
IVHRD+KPENLL+ G ++KL DFGLA V+G + GTP Y++PE++ +
Sbjct: 132 IVHRDLKPENLLLASKCKGA-AVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDP 190
Query: 567 YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL 626
YG VDIWA GVI YILL G+PPF E+ Q L+ QI AG +FP+P WD +T AK L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDED--QHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 627 ISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGV 686
I+QML +N R TA Q L HPWV ++ + M + T + + FN + + T +
Sbjct: 249 INQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTM 308
Query: 687 SVIMNTALDKEGQIFCSKHCQDSGRP-GMEPISPVPPSVEEIPVPGEAVPAPTPPESPT 744
V N + K +K +P S V P+ E P+ P T + T
Sbjct: 309 LVSRNFSAAKS---LLNKKSDGGVKPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNAT 364
>gi|26051210 calcium/calmodulin-dependent protein kinase II beta
isoform 4 [Homo sapiens]
Length = 517
Score = 225 bits (573), Expect = 1e-58
Identities = 131/363 (36%), Positives = 196/363 (53%), Gaps = 17/363 (4%)
Query: 391 EKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHL-IENEVSILRRVKHP 449
++Y++ + IG G F+VV+ C+ TG E+A KII+ K ++H +E E I R +KH
Sbjct: 12 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 71
Query: 450 NIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLS 509
NI+ L + + +LV +LV GG+LF+ I + Y+E D S + + A+ + H +
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 131
Query: 510 IVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETG 566
+VHRD+KPENLL+ G ++KL DFGLA V+G + GTP Y++PE++ +
Sbjct: 132 VVHRDLKPENLLLASKCKGA-AVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 190
Query: 567 YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL 626
YG VDIWA GVI YILL G+PPF E+ Q L+ QI AG +FP+P WD +T AK L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDED--QHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 627 ISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGV 686
I+QML +N R TA + L HPWV ++ + M + T + + FN + + T +
Sbjct: 249 INQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTM 308
Query: 687 SVIMNTALDKEGQIFCSKHCQDSGRPGMEP-ISPVPPSVEEIPVPGEAVPAPTPPESPTP 745
N F +K + G++P + S G PA P++
Sbjct: 309 LATRN---------FSAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVI 359
Query: 746 HPP 748
H P
Sbjct: 360 HNP 362
>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
isoform 4 [Homo sapiens]
Length = 495
Score = 224 bits (572), Expect = 2e-58
Identities = 121/310 (39%), Positives = 184/310 (59%), Gaps = 7/310 (2%)
Query: 391 EKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHL-IENEVSILRRVKHP 449
+ Y++ + +G G F+VV+ C+ +++ +E+A KII+ K ++H +E E I R +KHP
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 450 NIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLS 509
NI+ L + + +LV +LV GG+LF+ I + Y+E D S ++ + ++ ++H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHD 131
Query: 510 IVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETG 566
IVHRD+KPENLL+ G ++KL DFGLA V+G + GTP Y++PE++ +
Sbjct: 132 IVHRDLKPENLLLASKCKGA-AVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDP 190
Query: 567 YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL 626
YG VDIWA GVI YILL G+PPF E+ Q L+ QI AG +FP+P WD +T AK L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDED--QHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 627 ISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGV 686
I+QML +N R TA Q L HPWV ++ + M + T + + FN + + T +
Sbjct: 249 INQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTM 308
Query: 687 SVIMNTALDK 696
V N + K
Sbjct: 309 LVSRNFSAAK 318
>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
isoform 6 [Homo sapiens]
Length = 504
Score = 224 bits (572), Expect = 2e-58
Identities = 121/310 (39%), Positives = 184/310 (59%), Gaps = 7/310 (2%)
Query: 391 EKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHL-IENEVSILRRVKHP 449
+ Y++ + +G G F+VV+ C+ +++ +E+A KII+ K ++H +E E I R +KHP
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 450 NIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLS 509
NI+ L + + +LV +LV GG+LF+ I + Y+E D S ++ + ++ ++H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHD 131
Query: 510 IVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETG 566
IVHRD+KPENLL+ G ++KL DFGLA V+G + GTP Y++PE++ +
Sbjct: 132 IVHRDLKPENLLLASKCKGA-AVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDP 190
Query: 567 YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL 626
YG VDIWA GVI YILL G+PPF E+ Q L+ QI AG +FP+P WD +T AK L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDED--QHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 627 ISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGV 686
I+QML +N R TA Q L HPWV ++ + M + T + + FN + + T +
Sbjct: 249 INQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTM 308
Query: 687 SVIMNTALDK 696
V N + K
Sbjct: 309 LVSRNFSAAK 318
>gi|26051208 calcium/calmodulin-dependent protein kinase II beta
isoform 3 [Homo sapiens]
Length = 518
Score = 223 bits (568), Expect = 5e-58
Identities = 130/363 (35%), Positives = 196/363 (53%), Gaps = 16/363 (4%)
Query: 391 EKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHL-IENEVSILRRVKHP 449
++Y++ + IG G F+VV+ C+ TG E+A KII+ K ++H +E E I R +KH
Sbjct: 12 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 71
Query: 450 NIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLS 509
NI+ L + + +LV +LV GG+LF+ I + Y+E D S + + A+ + H +
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 131
Query: 510 IVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETG 566
+VHRD+KPENLL+ G ++KL DFGLA V+G + GTP Y++PE++ +
Sbjct: 132 VVHRDLKPENLLLASKCKGA-AVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 190
Query: 567 YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL 626
YG VDIWA GVI YILL G+PPF E+ Q L+ QI AG +FP+P WD +T AK L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDED--QHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 627 ISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGV 686
I+QML +N R TA + L HPWV ++ + M + T + + FN + + T +
Sbjct: 249 INQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTM 308
Query: 687 SVIMNTALDKEGQIFCSKHCQDSGRPGMEP-ISPVPPSVEEIPVPGEAVPAPTPPESPTP 745
N + +K + G++P + S G PA P++
Sbjct: 309 LATRNFS--------AAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVI 360
Query: 746 HPP 748
H P
Sbjct: 361 HNP 363
>gi|26051204 calcium/calmodulin-dependent protein kinase II beta
isoform 1 [Homo sapiens]
Length = 666
Score = 223 bits (567), Expect = 7e-58
Identities = 120/311 (38%), Positives = 182/311 (58%), Gaps = 7/311 (2%)
Query: 391 EKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHL-IENEVSILRRVKHP 449
++Y++ + IG G F+VV+ C+ TG E+A KII+ K ++H +E E I R +KH
Sbjct: 12 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 71
Query: 450 NIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLS 509
NI+ L + + +LV +LV GG+LF+ I + Y+E D S + + A+ + H +
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 131
Query: 510 IVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETG 566
+VHRD+KPENLL+ G ++KL DFGLA V+G + GTP Y++PE++ +
Sbjct: 132 VVHRDLKPENLLLASKCKGA-AVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 190
Query: 567 YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL 626
YG VDIWA GVI YILL G+PPF E+ Q L+ QI AG +FP+P WD +T AK L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDED--QHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 627 ISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGV 686
I+QML +N R TA + L HPWV ++ + M + T + + FN + + T +
Sbjct: 249 INQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTM 308
Query: 687 SVIMNTALDKE 697
N ++ ++
Sbjct: 309 LATRNFSVGRQ 319
>gi|26051214 calcium/calmodulin-dependent protein kinase II beta
isoform 6 [Homo sapiens]
Length = 492
Score = 223 bits (567), Expect = 7e-58
Identities = 120/311 (38%), Positives = 182/311 (58%), Gaps = 7/311 (2%)
Query: 391 EKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHL-IENEVSILRRVKHP 449
++Y++ + IG G F+VV+ C+ TG E+A KII+ K ++H +E E I R +KH
Sbjct: 12 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 71
Query: 450 NIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLS 509
NI+ L + + +LV +LV GG+LF+ I + Y+E D S + + A+ + H +
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 131
Query: 510 IVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETG 566
+VHRD+KPENLL+ G ++KL DFGLA V+G + GTP Y++PE++ +
Sbjct: 132 VVHRDLKPENLLLASKCKGA-AVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 190
Query: 567 YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL 626
YG VDIWA GVI YILL G+PPF E+ Q L+ QI AG +FP+P WD +T AK L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDED--QHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 627 ISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGV 686
I+QML +N R TA + L HPWV ++ + M + T + + FN + + T +
Sbjct: 249 INQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTM 308
Query: 687 SVIMNTALDKE 697
N ++ ++
Sbjct: 309 LATRNFSVGRQ 319
>gi|26051206 calcium/calmodulin-dependent protein kinase II beta
isoform 2 [Homo sapiens]
Length = 542
Score = 223 bits (567), Expect = 7e-58
Identities = 120/311 (38%), Positives = 182/311 (58%), Gaps = 7/311 (2%)
Query: 391 EKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHL-IENEVSILRRVKHP 449
++Y++ + IG G F+VV+ C+ TG E+A KII+ K ++H +E E I R +KH
Sbjct: 12 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 71
Query: 450 NIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLS 509
NI+ L + + +LV +LV GG+LF+ I + Y+E D S + + A+ + H +
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 131
Query: 510 IVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETG 566
+VHRD+KPENLL+ G ++KL DFGLA V+G + GTP Y++PE++ +
Sbjct: 132 VVHRDLKPENLLLASKCKGA-AVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 190
Query: 567 YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL 626
YG VDIWA GVI YILL G+PPF E+ Q L+ QI AG +FP+P WD +T AK L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDED--QHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 627 ISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGV 686
I+QML +N R TA + L HPWV ++ + M + T + + FN + + T +
Sbjct: 249 INQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTM 308
Query: 687 SVIMNTALDKE 697
N ++ ++
Sbjct: 309 LATRNFSVGRQ 319
>gi|26051218 calcium/calmodulin-dependent protein kinase II beta
isoform 8 [Homo sapiens]
Length = 449
Score = 223 bits (567), Expect = 7e-58
Identities = 121/311 (38%), Positives = 181/311 (58%), Gaps = 7/311 (2%)
Query: 391 EKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHL-IENEVSILRRVKHP 449
++Y++ + IG G F+VV+ C+ TG E+A KII+ K ++H +E E I R +KH
Sbjct: 12 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 71
Query: 450 NIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLS 509
NI+ L + + +LV +LV GG+LF+ I + Y+E D S + + A+ + H +
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 131
Query: 510 IVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETG 566
+VHRD+KPENLL+ G ++KL DFGLA V+G + GTP Y++PE++ +
Sbjct: 132 VVHRDLKPENLLLASKCKGA-AVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 190
Query: 567 YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL 626
YG VDIWA GVI YILL G+PPF E+ Q L+ QI AG +FP+P WD +T AK L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDED--QHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 627 ISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGV 686
I+QML +N R TA + L HPWV ++ + M + T + + FN + + T +
Sbjct: 249 INQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTM 308
Query: 687 SVIMNTALDKE 697
N + K+
Sbjct: 309 LATRNFSARKQ 319
>gi|26051216 calcium/calmodulin-dependent protein kinase II beta
isoform 7 [Homo sapiens]
Length = 479
Score = 222 bits (566), Expect = 9e-58
Identities = 118/287 (41%), Positives = 173/287 (60%), Gaps = 7/287 (2%)
Query: 391 EKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHL-IENEVSILRRVKHP 449
++Y++ + IG G F+VV+ C+ TG E+A KII+ K ++H +E E I R +KH
Sbjct: 12 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 71
Query: 450 NIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLS 509
NI+ L + + +LV +LV GG+LF+ I + Y+E D S + + A+ + H +
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 131
Query: 510 IVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETG 566
+VHRD+KPENLL+ G ++KL DFGLA V+G + GTP Y++PE++ +
Sbjct: 132 VVHRDLKPENLLLASKCKGA-AVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 190
Query: 567 YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL 626
YG VDIWA GVI YILL G+PPF E+ Q L+ QI AG +FP+P WD +T AK L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDED--QHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 627 ISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFN 673
I+QML +N R TA + L HPWV ++ + M + T + + FN
Sbjct: 249 INQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFN 295
>gi|26051212 calcium/calmodulin-dependent protein kinase II beta
isoform 5 [Homo sapiens]
Length = 503
Score = 222 bits (566), Expect = 9e-58
Identities = 118/287 (41%), Positives = 173/287 (60%), Gaps = 7/287 (2%)
Query: 391 EKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHL-IENEVSILRRVKHP 449
++Y++ + IG G F+VV+ C+ TG E+A KII+ K ++H +E E I R +KH
Sbjct: 12 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 71
Query: 450 NIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLS 509
NI+ L + + +LV +LV GG+LF+ I + Y+E D S + + A+ + H +
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 131
Query: 510 IVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETG 566
+VHRD+KPENLL+ G ++KL DFGLA V+G + GTP Y++PE++ +
Sbjct: 132 VVHRDLKPENLLLASKCKGA-AVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 190
Query: 567 YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL 626
YG VDIWA GVI YILL G+PPF E+ Q L+ QI AG +FP+P WD +T AK L
Sbjct: 191 YGKPVDIWACGVILYILLVGYPPFWDED--QHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 248
Query: 627 ISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFN 673
I+QML +N R TA + L HPWV ++ + M + T + + FN
Sbjct: 249 INQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFN 295
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 220 bits (561), Expect = 3e-57
Identities = 138/378 (36%), Positives = 206/378 (54%), Gaps = 22/378 (5%)
Query: 354 SAHGRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDR 413
SA SS + P + ++G S L + +++ +G G ++V C +
Sbjct: 10 SASSCSSVTASAAPGTASLVPDYWIDG---SNRDALSDFFEVESELGRGATSIVYRCKQK 66
Query: 414 STGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKG 473
T K +ALK++ K + ++ E+ +L R+ HPNII L E ET TE+ LV+ELV G
Sbjct: 67 GTQKPYALKVLKKTV---DKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTG 123
Query: 474 GDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLK 533
G+LFD I Y+ERD + V + A+ YLH IVHRD+KPENLL P LK
Sbjct: 124 GELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYAT-PAPDAPLK 182
Query: 534 LGDFGLATVVEGP--LYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFR 591
+ DFGL+ +VE + TVCGTP Y APEI+ YG +VD+W+ G+ITYILLCGF PF
Sbjct: 183 IADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFY 242
Query: 592 SENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVS 651
E + +F +IL + F +P+WD ++ +AK+L+ +++ ++ + R T Q L HPWV+
Sbjct: 243 DERG-DQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVT 301
Query: 652 DDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGV--SVIMNTALDKEGQIFCSKHCQDS 709
A+ N + + K Q F NA K + V S + +A G I Q+S
Sbjct: 302 GKAA--NFVHMDTAQKKLQEF-NARRKLKAAVKAVVASSRLGSASSSHGSI------QES 352
Query: 710 GRPGMEPISPVPPSVEEI 727
+ +P SP+ E++
Sbjct: 353 HKASRDP-SPIQDGNEDM 369
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,384,105
Number of Sequences: 37866
Number of extensions: 1749514
Number of successful extensions: 24963
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 772
Number of HSP's successfully gapped in prelim test: 605
Number of HSP's that attempted gapping in prelim test: 15685
Number of HSP's gapped (non-prelim): 6760
length of query: 765
length of database: 18,247,518
effective HSP length: 110
effective length of query: 655
effective length of database: 14,082,258
effective search space: 9223878990
effective search space used: 9223878990
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.