Search of human proteins with 155030196

Search of human proteins with 155030196

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3
[Homo sapiens]
         (607 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3 [...  1162   0.0  
gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1 [...  1160   0.0  
gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2 [...  1154   0.0  
gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5 [...  1035   0.0  
gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4 [...  1033   0.0  
gi|155030202 RAP1, GTP-GDP dissociation stimulator 1 isoform 6 [...   759   0.0  
gi|189409124 armadillo repeat containing 3 [Homo sapiens]              54   3e-07
gi|224589129 karyopherin 7 [Homo sapiens]                              48   2e-05
gi|31657114 armadillo repeat containing 4 [Homo sapiens]               47   4e-05
gi|39812229 karyopherin alpha 5 [Homo sapiens]                         46   9e-05
gi|4504897 karyopherin alpha 2 [Homo sapiens]                          44   4e-04
gi|11034811 catenin (cadherin-associated protein), delta 2 (neur...    40   0.006
gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens]     39   0.011
gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]     38   0.024
gi|4504811 junction plakoglobin [Homo sapiens]                         38   0.031
gi|12056468 junction plakoglobin [Homo sapiens]                        38   0.031
gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]         38   0.031
gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]        38   0.031
gi|148227672 catenin (cadherin-associated protein), beta 1, 88kD...    37   0.053
gi|148233338 catenin (cadherin-associated protein), beta 1, 88kD...    37   0.053
gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa ...    37   0.053
gi|15529984 armadillo repeat containing 6 [Homo sapiens]               37   0.069
gi|7106299 ataxin 10 [Homo sapiens]                                    36   0.12 
gi|4504901 karyopherin alpha 4 [Homo sapiens]                          35   0.15 
gi|222144293 karyopherin alpha 1 [Homo sapiens]                        34   0.45 
gi|146231975 catenin, delta 1 isoform 3A [Homo sapiens]                34   0.45 
gi|146231948 catenin, delta 1 isoform 3A [Homo sapiens]                34   0.45 
gi|146231994 catenin, delta 1 isoform 3A [Homo sapiens]                34   0.45 
gi|146231977 catenin, delta 1 isoform 3AC [Homo sapiens]               34   0.45 
gi|146231946 catenin, delta 1 isoform 3B [Homo sapiens]                34   0.45 

>gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3
           [Homo sapiens]
          Length = 607

 Score = 1162 bits (3006), Expect = 0.0
 Identities = 607/607 (100%), Positives = 607/607 (100%)

Query: 1   MDNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTP 60
           MDNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTP
Sbjct: 1   MDNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTP 60

Query: 61  QSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDS 120
           QSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDS
Sbjct: 61  QSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDS 120

Query: 121 HEGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMG 180
           HEGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMG
Sbjct: 121 HEGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMG 180

Query: 181 VIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDK 240
           VIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDK
Sbjct: 181 VIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDK 240

Query: 241 REMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLL 300
           REMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLL
Sbjct: 241 REMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLL 300

Query: 301 LGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVE 360
           LGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVE
Sbjct: 301 LGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVE 360

Query: 361 KLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQF 420
           KLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQF
Sbjct: 361 KLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQF 420

Query: 421 KLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSK 480
           KLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSK
Sbjct: 421 KLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSK 480

Query: 481 DVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHR 540
           DVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHR
Sbjct: 481 DVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHR 540

Query: 541 LLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTE 600
           LLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTE
Sbjct: 541 LLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTE 600

Query: 601 QRLTVES 607
           QRLTVES
Sbjct: 601 QRLTVES 607


>gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1
           [Homo sapiens]
          Length = 608

 Score = 1160 bits (3001), Expect = 0.0
 Identities = 606/606 (100%), Positives = 606/606 (100%)

Query: 2   DNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQ 61
           DNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQ
Sbjct: 3   DNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQ 62

Query: 62  SSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSH 121
           SSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSH
Sbjct: 63  SSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSH 122

Query: 122 EGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGV 181
           EGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGV
Sbjct: 123 EGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGV 182

Query: 182 IPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKR 241
           IPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKR
Sbjct: 183 IPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKR 242

Query: 242 EMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLL 301
           EMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLL
Sbjct: 243 EMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLL 302

Query: 302 GDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEK 361
           GDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEK
Sbjct: 303 GDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEK 362

Query: 362 LMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 421
           LMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK
Sbjct: 363 LMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 422

Query: 422 LLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKD 481
           LLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKD
Sbjct: 423 LLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKD 482

Query: 482 VIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRL 541
           VIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRL
Sbjct: 483 VIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRL 542

Query: 542 LADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQ 601
           LADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQ
Sbjct: 543 LADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQ 602

Query: 602 RLTVES 607
           RLTVES
Sbjct: 603 RLTVES 608


>gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2
           [Homo sapiens]
          Length = 607

 Score = 1154 bits (2985), Expect = 0.0
 Identities = 605/606 (99%), Positives = 605/606 (99%), Gaps = 1/606 (0%)

Query: 2   DNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQ 61
           DNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQ
Sbjct: 3   DNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQ 62

Query: 62  SSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSH 121
           SSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSH
Sbjct: 63  SSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSH 122

Query: 122 EGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGV 181
           EGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGV
Sbjct: 123 EGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGV 182

Query: 182 IPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKR 241
           IPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKR
Sbjct: 183 IPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKR 242

Query: 242 EMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLL 301
           EMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLL
Sbjct: 243 EMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLL 302

Query: 302 GDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEK 361
           GDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEK
Sbjct: 303 GDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEK 362

Query: 362 LMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 421
           LMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK
Sbjct: 363 LMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 422

Query: 422 LLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKD 481
           LLGTLRMLIDAQ EAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKD
Sbjct: 423 LLGTLRMLIDAQ-EAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKD 481

Query: 482 VIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRL 541
           VIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRL
Sbjct: 482 VIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRL 541

Query: 542 LADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQ 601
           LADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQ
Sbjct: 542 LADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQ 601

Query: 602 RLTVES 607
           RLTVES
Sbjct: 602 RLTVES 607


>gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5
           [Homo sapiens]
          Length = 558

 Score = 1035 bits (2676), Expect = 0.0
 Identities = 555/607 (91%), Positives = 557/607 (91%), Gaps = 49/607 (8%)

Query: 1   MDNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTP 60
           MDNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTP
Sbjct: 1   MDNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTP 60

Query: 61  QSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDS 120
           QSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICY  
Sbjct: 61  QSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICY-- 118

Query: 121 HEGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMG 180
                                                          ++ SLQAQLINMG
Sbjct: 119 -----------------------------------------------DSHSLQAQLINMG 131

Query: 181 VIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDK 240
           VIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDK
Sbjct: 132 VIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDK 191

Query: 241 REMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLL 300
           REMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLL
Sbjct: 192 REMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLL 251

Query: 301 LGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVE 360
           LGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVE
Sbjct: 252 LGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVE 311

Query: 361 KLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQF 420
           KLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQF
Sbjct: 312 KLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQF 371

Query: 421 KLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSK 480
           KLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSK
Sbjct: 372 KLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSK 431

Query: 481 DVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHR 540
           DVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHR
Sbjct: 432 DVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHR 491

Query: 541 LLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTE 600
           LLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTE
Sbjct: 492 LLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTE 551

Query: 601 QRLTVES 607
           QRLTVES
Sbjct: 552 QRLTVES 558


>gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4
           [Homo sapiens]
          Length = 559

 Score = 1033 bits (2671), Expect = 0.0
 Identities = 554/606 (91%), Positives = 556/606 (91%), Gaps = 49/606 (8%)

Query: 2   DNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQ 61
           DNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQ
Sbjct: 3   DNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQ 62

Query: 62  SSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSH 121
           SSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICY   
Sbjct: 63  SSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICY--- 119

Query: 122 EGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGV 181
                                                         ++ SLQAQLINMGV
Sbjct: 120 ----------------------------------------------DSHSLQAQLINMGV 133

Query: 182 IPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKR 241
           IPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKR
Sbjct: 134 IPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKR 193

Query: 242 EMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLL 301
           EMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLL
Sbjct: 194 EMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLL 253

Query: 302 GDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEK 361
           GDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEK
Sbjct: 254 GDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEK 313

Query: 362 LMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 421
           LMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK
Sbjct: 314 LMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 373

Query: 422 LLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKD 481
           LLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKD
Sbjct: 374 LLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKD 433

Query: 482 VIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRL 541
           VIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRL
Sbjct: 434 VIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRL 493

Query: 542 LADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQ 601
           LADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQ
Sbjct: 494 LADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQ 553

Query: 602 RLTVES 607
           RLTVES
Sbjct: 554 RLTVES 559


>gi|155030202 RAP1, GTP-GDP dissociation stimulator 1 isoform 6
           [Homo sapiens]
          Length = 516

 Score =  759 bits (1959), Expect = 0.0
 Identities = 406/441 (92%), Positives = 417/441 (94%), Gaps = 3/441 (0%)

Query: 168 ENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLA-ELESSKEQFASTNIAE 226
           +N+ ++   ++ G+I  LV+LL    Q   L      A GN+  + +SSKEQFASTNIAE
Sbjct: 78  KNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGR--ALGNICYDSQSSKEQFASTNIAE 135

Query: 227 ELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDI 286
           ELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDI
Sbjct: 136 ELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDI 195

Query: 287 TELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARN 346
           TELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARN
Sbjct: 196 TELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARN 255

Query: 347 DANCIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEA 406
           DANCIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEA
Sbjct: 256 DANCIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEA 315

Query: 407 VLKFLKSEMPPVQFKLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGES 466
           VLKFLKSEMPPVQFKLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGES
Sbjct: 316 VLKFLKSEMPPVQFKLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGES 375

Query: 467 NRLLSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAE 526
           NRLLSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAE
Sbjct: 376 NRLLSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAE 435

Query: 527 KDLESAKLVQILHRLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRS 586
           KDLESAKLVQILHRLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRS
Sbjct: 436 KDLESAKLVQILHRLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRS 495

Query: 587 HENKSVAQQASLTEQRLTVES 607
           HENKSVAQQASLTEQRLTVES
Sbjct: 496 HENKSVAQQASLTEQRLTVES 516


>gi|189409124 armadillo repeat containing 3 [Homo sapiens]
          Length = 872

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 81/355 (22%), Positives = 154/355 (43%), Gaps = 38/355 (10%)

Query: 258 KLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSV 317
           K  L+E G VE L +++        ED I  ++  + ++  +L  +  ++KL    +  V
Sbjct: 60  KTTLLELGAVEPLTKLLTH------EDKI--VRRNATMIFGILASNNDVKKLLR--ELDV 109

Query: 318 FQRVLSWI-PSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVEDGNVT 376
              V++ + P     +    +L +AN +    + + + ++G +E L+ LL     D    
Sbjct: 110 MNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPD---- 165

Query: 377 VQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQAEA 436
           V+  ++  + NL      +AK+        +L  LKSE P +Q   L TL ++ +   E+
Sbjct: 166 VKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIAN-DKES 224

Query: 437 AEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKDVIKTIVQSGGIKHLV 496
              L  N  L + L++  E K+   +  E+   L+ +    +  D +  I Q+GG+K L+
Sbjct: 225 RTMLRDNQGL-DHLIKILETKELNDLHIEA---LAVIANCLEDMDTMVQIQQTGGLKKLL 280

Query: 497 TMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLV------QILHRLLADERSAPE 550
           + A       +N  +  +   AA  +  A  D E+ KL       + L  LL  E    +
Sbjct: 281 SFA-------ENSTIPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTK 333

Query: 551 IKYNSMV-LICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQRLT 604
           I  +  +  +C   GS    K+  +   +  + +L   +N+ V + A+L    LT
Sbjct: 334 IAASQAISAMCENSGS----KDFFNNQGIPQLIQLLKSDNEEVREAAALALANLT 384



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 98/535 (18%), Positives = 219/535 (40%), Gaps = 63/535 (11%)

Query: 86  VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCS 145
           +++   + +V +LNS ++E+L +   A+        E ++ + + G     ++ L  L +
Sbjct: 22  IESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELG----AVEPLTKLLT 77

Query: 146 ITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVA 205
             D    +  T+  G+L +    N+ ++  L  + V+ +++  L    +   + E   + 
Sbjct: 78  HEDKIVRRNATMIFGILAS----NNDVKKLLRELDVMNSVIAQLAPE-EEVVIHEFASLC 132

Query: 206 FGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAG 265
             N++   +SK Q       E L++L     + D ++   E +  L ++   + +L E  
Sbjct: 133 LANMSAEYTSKVQIFEHGGLEPLIRLLSSP-DPDVKKNSMECIYNLVQDFQCRAKLQELN 191

Query: 266 LVECLLEIVQQK--------------VDSDKED--------------DITELKTGSDLMV 297
            +  +L++++ +              + +DKE                I E K  +DL +
Sbjct: 192 AIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKILETKELNDLHI 251

Query: 298 --LLLLGD--ESMQKLFEGGKGSVFQRVLSWIPSNN-HQLQLAGALAIANFARNDANCIH 352
             L ++ +  E M  + +  +    +++LS+  ++    +Q   A AI   A +  N   
Sbjct: 252 EALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPEN-RK 310

Query: 353 MVDNGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAV--LKF 410
           +     VEK +  L     DG       A+SA+   +    +K    + G+ + +  LK 
Sbjct: 311 LFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENS---GSKDFFNNQGIPQLIQLLKS 367

Query: 411 LKSEMPPVQFKLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLL 470
              E+       L  L     A A AA +       ++ L+    +K    +        
Sbjct: 368 DNEEVREAAALALANLTTCNPANANAAAEADG----IDPLINLLSSKRDGAIAN-----A 418

Query: 471 SALIRHSKSKDVIKTIVQSGGIKH-LVTMATSEHVIMQNEALVALALIAALELGTAEKDL 529
           + ++ +   ++ ++  +Q+  I H +++   S + ++Q++A  ALA+ A      A  +L
Sbjct: 419 ATVLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKA--ALAVTATACDVEARTEL 476

Query: 530 ESAKLVQILHRLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKL 584
            ++  ++ L  LL  +        +  V++CA  G E    E+  L  LD++ ++
Sbjct: 477 RNSGGLEPLVELLRSKNDEVRKHASWAVMVCA--GDELTANELCRLGALDILEEV 529


>gi|224589129 karyopherin 7 [Homo sapiens]
          Length = 516

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 66/287 (22%), Positives = 117/287 (40%), Gaps = 26/287 (9%)

Query: 86  VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCS 145
           V+ G I PL++LL+S +  V  Q   ALGNI  D  E R  V  +      I HL +L S
Sbjct: 153 VEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSN----AIPHLLALIS 208

Query: 146 ITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVA 205
            T P     L      L N     +          ++P L+ LL  H  +  L++ C  A
Sbjct: 209 PTLPIT--FLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQ-HQDSEVLSDACW-A 264

Query: 206 FGNLAELESSK-EQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEA 264
              L +  + +  Q  +T +   LV L      +     +  V   +   D      ++A
Sbjct: 265 LSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDA 324

Query: 265 GLVECLLEIVQQKVDSDKED---DITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRV 321
           G++  L +++Q    S +++    ++ +  G    +  LL  +            V   +
Sbjct: 325 GMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYD------------VLPPL 372

Query: 322 LSWIPSNNHQLQLAGALAIANFARNDA--NCIHMVDNGIVEKLMDLL 366
           ++ + +   ++Q      +ANFA        I +V +G++E L++LL
Sbjct: 373 VALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLL 419


>gi|31657114 armadillo repeat containing 4 [Homo sapiens]
          Length = 1044

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 53/219 (24%), Positives = 91/219 (41%), Gaps = 17/219 (7%)

Query: 33  ALAQNNTETSEKIQASGILQLFASLL-TPQSSCKAKVANIIAEVAKNEFMRIPCVDAGLI 91
           +LAQ   + +  I+  G L++  +LL T +  CK     I+ E++ N  +R   VD G +
Sbjct: 480 SLAQETCQLA--IRDVGGLEVLINLLETDEVKCKIGSLKILKEISHNPQIRQNIVDLGGL 537

Query: 92  SPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPAN 151
             +V +L+S  + +       + N+       R  V Q GG   ++  L      T PA 
Sbjct: 538 PIMVNILDSPHKSLKCLAAETIANVA-KFKRARRVVRQHGGITKLVALLDCAHDSTKPAQ 596

Query: 152 EKLL------TVFCGMLMNYSNENDSLQAQLI-NMGVIPTLVKLLGIHCQNAALTEMCLV 204
             L          CG L  +S        + I   G IP L +LL    +N     M + 
Sbjct: 597 SSLYEARDVEVARCGALALWSCSKSHTNKEAIRKAGGIPLLARLLKTSHEN-----MLIP 651

Query: 205 AFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREM 243
             G L E  +S+E + +   AE +++   K +  +  ++
Sbjct: 652 VVGTLQEC-ASEENYRAAIKAERIIENLVKNLNSENEQL 689



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 76/379 (20%), Positives = 153/379 (40%), Gaps = 40/379 (10%)

Query: 18   KTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQSSCKAKVANIIAEVAK 77
            + E   E C   + Q     + ET + ++  G L+  ASLL    + K ++A +   + K
Sbjct: 685  ENEQLQEHCAMAIYQCA--EDKETRDLVRLHGGLKPLASLLNNTDN-KERLAAVTGAIWK 741

Query: 78   NEFMRIPCV---DAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQ 134
                +       +   I  LV LL  + +EVL+    ALG  C +  E R  V + GG Q
Sbjct: 742  CSISKENVTKFREYKAIETLVGLLTDQPEEVLVNVVGALGECCQE-RENRVIVRKCGGIQ 800

Query: 135  IVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTL--VKLLGIH 192
                          P    L+ +   +L+N +    +   +  +M +I  L  V+LL   
Sbjct: 801  --------------PLVNLLVGINQALLVNVTKAVGACAVEPESMMIIDRLDGVRLLWSL 846

Query: 193  CQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAP-- 250
             +N         A+     ++++K+           ++L    ++ D +E++  V A   
Sbjct: 847  LKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKEVLASVCAAIT 906

Query: 251  -LAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKL 309
             +A++      + + G+V  L ++      ++  ++         +    + G    +  
Sbjct: 907  NIAKDQENLAVITDHGVVPLLSKL------ANTNNNKLRHHLAEAISRCCMWG----RNR 956

Query: 310  FEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRH 369
               G+      ++ ++ SN+  +  A A A+   + +  NCI M +NG V+ L+D++   
Sbjct: 957  VAFGEHKAVAPLVRYLKSNDTNVHRATAQALYQLSEDADNCITMHENGAVKLLLDMVGSP 1016

Query: 370  VEDGNVTVQHAALSALRNL 388
             +D    +Q AA   + N+
Sbjct: 1017 DQD----LQEAAAGCISNI 1031



 Score = 37.7 bits (86), Expect = 0.031
 Identities = 83/416 (19%), Positives = 160/416 (38%), Gaps = 29/416 (6%)

Query: 1   MDNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTP 60
           +D   D+ K  + +  +  +  +  C    L + ++++T      +A GI  L   L T 
Sbjct: 585 LDCAHDSTKPAQSSLYEARDVEVARCGALALWSCSKSHTNKEAIRKAGGIPLLARLLKTS 644

Query: 61  QSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDS 120
             +    V   + E A  E  R       +I  LV+ LNS+++++      A+   C + 
Sbjct: 645 HENMLIPVVGTLQECASEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQ-CAED 703

Query: 121 HEGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMG 180
            E R  V   GG    +  L SL + TD  N++ L    G +   S   +++  +     
Sbjct: 704 KETRDLVRLHGG----LKPLASLLNNTD--NKERLAAVTGAIWKCSISKENV-TKFREYK 756

Query: 181 VIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDK 240
            I TLV LL    +   +    + A G   +   ++         + LV L     +   
Sbjct: 757 AIETLVGLLTDQPEEVLVN--VVGALGECCQERENRVIVRKCGGIQPLVNLLVGINQALL 814

Query: 241 REMIFEVLAPLAENDAIKL--QLVEAGLVECLLEIVQQKVDSDKEDDITE-LKTGSDLMV 297
             +   V A   E +++ +  +L    L+  LL+     V +     +   +K   D   
Sbjct: 815 VNVTKAVGACAVEPESMMIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDA-- 872

Query: 298 LLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNG 357
                   M + F GG     + +++ + S+N ++  +   AI N A++  N   + D+G
Sbjct: 873 ------GEMVRSFVGG----LELIVNLLKSDNKEVLASVCAAITNIAKDQENLAVITDHG 922

Query: 358 IVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKS 413
           +V     LL +     N  ++H    A+    +   N+           ++++LKS
Sbjct: 923 VV----PLLSKLANTNNNKLRHHLAEAISRCCMWGRNRVAFGEHKAVAPLVRYLKS 974


>gi|39812229 karyopherin alpha 5 [Homo sapiens]
          Length = 539

 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 66/280 (23%), Positives = 116/280 (41%), Gaps = 44/280 (15%)

Query: 38  NTETSEKIQASGILQLFASLLTPQSSC--KAKVANIIAEVAKNEFMRIPCV-DAGLISPL 94
           N    + IQ  G++Q F   L    +C  + + A  +  +A   F+    V + G +   
Sbjct: 116 NPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIF 175

Query: 95  VQLLNSKDQEVLLQTGRALGNICYDSHEGRSAV----------------DQAGGAQIVID 138
           ++LLNS+ ++V  Q   ALGNI  D+ E R  V                ++    +  + 
Sbjct: 176 IKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVW 235

Query: 139 HLRSLCSITDP--------------------ANEKLLTVFCGMLMNYSN-ENDSLQAQLI 177
            L +LC   +P                    ++  +L   C  L   S+  ND +QA +I
Sbjct: 236 ALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQA-VI 294

Query: 178 NMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQ-FASTNIAEELVKLFKKQI 236
           + GV   LV+LL +H  +  +    L A GN+   +  + Q   + +    L+ L     
Sbjct: 295 DSGVCRRLVELL-MH-NDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPK 352

Query: 237 EHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQ 276
           E  ++E  + V    A N A    +++A +   L+EI+Q+
Sbjct: 353 ESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQK 392


>gi|4504897 karyopherin alpha 2 [Homo sapiens]
          Length = 529

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 96/439 (21%), Positives = 168/439 (38%), Gaps = 85/439 (19%)

Query: 34  LAQNNTETSEKIQASGILQLFASLL--TPQSSCKAKVANIIAEVAKNEFMRIPCV-DAGL 90
           L++      + I  +G++  F S L  T  S  + + A  +  +A     +   V D G 
Sbjct: 104 LSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGA 163

Query: 91  ISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPA 150
           I   + LL S    +  Q   ALGNI  D    R  V + G     +D L +L ++ D  
Sbjct: 164 IPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYG----AVDPLLALLAVPD-- 217

Query: 151 NEKLLTVFCGMLMNYS--------NENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMC 202
              + ++ CG L N +        N+N +     +   ++PTLV+LL  H     L + C
Sbjct: 218 ---MSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQ-ILPTLVRLLH-HDDPEVLADTC 272

Query: 203 LVAFGNLAELESSK-EQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQL 261
             A   L +  + +      T +  +LVKL                        A +L +
Sbjct: 273 W-AISYLTDGPNERIGMVVKTGVVPQLVKLL----------------------GASELPI 309

Query: 262 VEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRV 321
           V   L                   I  + TG+         DE  Q + + G  +VF  +
Sbjct: 310 VTPAL-----------------RAIGNIVTGT---------DEQTQVVIDAGALAVFPSL 343

Query: 322 LSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAA 381
           L+  P  N Q +    ++     R D     +V++G+V  L+ +L +     +   Q  A
Sbjct: 344 LT-NPKTNIQKEATWTMSNITAGRQD-QIQQVVNHGLVPFLVSVLSK----ADFKTQKEA 397

Query: 382 LSALRNLAI--PVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQAEAAEQ 439
           + A+ N      V     ++  G+ E ++  L ++   +   +L  +  +     +AAE+
Sbjct: 398 VWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIF----QAAEK 453

Query: 440 LGKNVKLVERLVEWCEAKD 458
           LG+  KL   ++E C   D
Sbjct: 454 LGETEKL-SIMIEECGGLD 471


>gi|11034811 catenin (cadherin-associated protein), delta 2 (neural
           plakophilin-related arm-repeat protein) [Homo sapiens]
          Length = 1225

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 26/98 (26%), Positives = 47/98 (47%), Gaps = 9/98 (9%)

Query: 94  LVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPANEK 153
           ++Q+L  +   V       L ++C+  ++ ++ + + GG Q+++D       + D    +
Sbjct: 555 VIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVD-------LLDHRMTE 607

Query: 154 LLTVFCGMLMN--YSNENDSLQAQLINMGVIPTLVKLL 189
           +    CG L N  Y   ND  +  L N G IP LV+LL
Sbjct: 608 VHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLL 645


>gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens]
          Length = 493

 Score = 39.3 bits (90), Expect = 0.011
 Identities = 49/218 (22%), Positives = 87/218 (39%), Gaps = 34/218 (15%)

Query: 17  DKTEDSLEGCLDCLL------QALAQNNTETSEKIQASGILQLFASLLTPQSSCKAKVAN 70
           D  E++ EGC+  +L      Q L Q    T EK +   ++ L   L  P++        
Sbjct: 48  DAPEEAGEGCVAAILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQHPET-------- 99

Query: 71  IIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQA 130
                 +  F+R+     G +  LV LL S    + L+  R L  +   SH  +S V   
Sbjct: 100 ------QQTFIRLE----GSMRTLVGLLTSNQALLQLEAARCLHEL---SHSEQSTV--- 143

Query: 131 GGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLG 190
             A+  +     L +     +   + +    L N   E+++++ QL+  G++P L     
Sbjct: 144 --AEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAAC-- 199

Query: 191 IHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEEL 228
           I   + A+ E    A   L + E + E+   + +A  L
Sbjct: 200 IQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTL 237


>gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]
          Length = 1363

 Score = 38.1 bits (87), Expect = 0.024
 Identities = 90/445 (20%), Positives = 180/445 (40%), Gaps = 60/445 (13%)

Query: 169  NDSLQAQLINMGVIPTLVKLL-----GIHCQNAALTEMCLVAFGNLAELESSKEQFASTN 223
            ND     +++ G IP L+ LL      + C+   L         N++  +S+        
Sbjct: 660  NDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGL-------LSNISTHKSAVHALVEAG 712

Query: 224  IAEELVKLF--KKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSD 281
                L+ L    +   H +  +I   +A     D I     +   +  L+ ++   +++ 
Sbjct: 713  GIPSLINLLVCDEPEVHSRCAVILYDIAQCENKDVI----AKYNGIPSLINLLNLNIEN- 767

Query: 282  KEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIA 341
                   L    + + +L +G+E+ Q+     KG  +  ++ ++ S++  L+   + AIA
Sbjct: 768  ------VLVNVMNCIRVLCIGNENNQRAVREHKGLPY--LIRFLSSDSDVLKAVSSAAIA 819

Query: 342  NFARNDANCIHMVD-NGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAI--PVINKAKM 398
               R++      +   G +  L+ L     +   ++VQ     A+ +LA    +I KA  
Sbjct: 820  EVGRDNKEIQDAIAMEGAIPPLVALF----KGKQISVQMKGAMAVESLASHNALIQKA-F 874

Query: 399  LSAGVTEAVLKFLKSEMPPVQ----FKLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWC 454
            L   +T+ +LK LK+    V+      L       +  Q   AEQ+G +  ++  L+   
Sbjct: 875  LEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAEQIGYSF-IINMLLSPS 933

Query: 455  EAKDHAGVMGESNRLLSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVAL 514
                + G  GE+   LS   R  +++     I +  GI  LV +      I +   L  +
Sbjct: 934  AKMQYVG--GEAVIALSKDSRMHQNQ-----ICEGNGIAPLVRLLRIS-TIAEGTLLSVI 985

Query: 515  ALIAALELGTA-------EKDLESAKLVQILHRLLADERSAPEIKYN-SMVLICALMGSE 566
              + ++ +G A       ++ +       +L +LL +  S P IK   +  L C ++G++
Sbjct: 986  RAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLLRNHPS-PNIKVEVAFSLACIVLGND 1044

Query: 567  CLHKEVQD---LAFLDVVSKLRSHE 588
             L K++ +     + DV+  L S E
Sbjct: 1045 VLQKDLHENEGFEYADVLYLLHSTE 1069


>gi|4504811 junction plakoglobin [Homo sapiens]
          Length = 745

 Score = 37.7 bits (86), Expect = 0.031
 Identities = 91/422 (21%), Positives = 159/422 (37%), Gaps = 65/422 (15%)

Query: 91  ISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPA 150
           +  +V LLN  + + L  T   L  + Y + E +  +   GG Q ++  +R+       +
Sbjct: 270 LQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY------S 323

Query: 151 NEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLA 210
            EKLL      ++   +   S +  ++  G +  L K L     +  L + CL    NL+
Sbjct: 324 YEKLLWT-TSRVLKVLSVCPSNKPAIVEAGGMQALGKHL--TSNSPRLVQNCLWTLRNLS 380

Query: 211 ELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLA----ENDAIKLQLVEAGL 266
           ++ + +E        E ++K+   Q+  D   ++      L+     N   K  + +   
Sbjct: 381 DVATKQEGL------ESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSG 434

Query: 267 VECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIP 326
           VE L+  + +  D   +DDITE        V  L    S     E  + SV  R+   IP
Sbjct: 435 VEALIHAILRAGD---KDDITE------PAVCALRHLTSRHPEAEMAQNSV--RLNYGIP 483

Query: 327 S--------NNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLL-------DRHVE 371
           +        N   L  A    I N A   AN   + +  ++ +L+ LL        RHV 
Sbjct: 484 AIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA 543

Query: 372 DGN----------VTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 421
            G             +      AL  LA   +N+ ++         ++ L S +  +Q  
Sbjct: 544 AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRV 603

Query: 422 LLGTLRMLIDAQ--AEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS 479
             G L  L   +  A+A +  G +  L+E L        H+   G +    + L R S+ 
Sbjct: 604 AAGVLCELAQDKEAADAIDAEGASAPLMELL--------HSRNEGTATYAAAVLFRISED 655

Query: 480 KD 481
           K+
Sbjct: 656 KN 657


>gi|12056468 junction plakoglobin [Homo sapiens]
          Length = 745

 Score = 37.7 bits (86), Expect = 0.031
 Identities = 91/422 (21%), Positives = 159/422 (37%), Gaps = 65/422 (15%)

Query: 91  ISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPA 150
           +  +V LLN  + + L  T   L  + Y + E +  +   GG Q ++  +R+       +
Sbjct: 270 LQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY------S 323

Query: 151 NEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLA 210
            EKLL      ++   +   S +  ++  G +  L K L     +  L + CL    NL+
Sbjct: 324 YEKLLWT-TSRVLKVLSVCPSNKPAIVEAGGMQALGKHL--TSNSPRLVQNCLWTLRNLS 380

Query: 211 ELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLA----ENDAIKLQLVEAGL 266
           ++ + +E        E ++K+   Q+  D   ++      L+     N   K  + +   
Sbjct: 381 DVATKQEGL------ESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSG 434

Query: 267 VECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIP 326
           VE L+  + +  D   +DDITE        V  L    S     E  + SV  R+   IP
Sbjct: 435 VEALIHAILRAGD---KDDITE------PAVCALRHLTSRHPEAEMAQNSV--RLNYGIP 483

Query: 327 S--------NNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLL-------DRHVE 371
           +        N   L  A    I N A   AN   + +  ++ +L+ LL        RHV 
Sbjct: 484 AIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA 543

Query: 372 DGN----------VTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 421
            G             +      AL  LA   +N+ ++         ++ L S +  +Q  
Sbjct: 544 AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRV 603

Query: 422 LLGTLRMLIDAQ--AEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS 479
             G L  L   +  A+A +  G +  L+E L        H+   G +    + L R S+ 
Sbjct: 604 AAGVLCELAQDKEAADAIDAEGASAPLMELL--------HSRNEGTATYAAAVLFRISED 655

Query: 480 KD 481
           K+
Sbjct: 656 KN 657


>gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]
          Length = 509

 Score = 37.7 bits (86), Expect = 0.031
 Identities = 29/134 (21%), Positives = 61/134 (45%), Gaps = 2/134 (1%)

Query: 11  LKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKI-QASGILQLFASLLTPQSSCKAKVA 69
           L +  + + E +L+      L  +A+++ E ++ +  A  +  L   +L P +  K ++ 
Sbjct: 171 LLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQIL 230

Query: 70  NIIAEVAKNEF-MRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVD 128
           + +++V+K+   +    V+A +   ++  L  KD+ V       +  I   + E    V 
Sbjct: 231 SALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVV 290

Query: 129 QAGGAQIVIDHLRS 142
            AGG   VID + S
Sbjct: 291 NAGGVAAVIDCIGS 304



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 5/90 (5%)

Query: 470 LSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDL 529
           LS + +HS   ++ +T+V +G + HL  M  +    ++++ L AL+ ++   +  AE  +
Sbjct: 191 LSDIAKHSP--ELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVV 248

Query: 530 ESAKLVQILHRLLADERSAPEIKYNSMVLI 559
           E A++  ++   L D+     +K N+  LI
Sbjct: 249 E-AEIFPVVLTCLKDKDE--YVKKNASTLI 275


>gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]
          Length = 458

 Score = 37.7 bits (86), Expect = 0.031
 Identities = 29/134 (21%), Positives = 61/134 (45%), Gaps = 2/134 (1%)

Query: 11  LKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKI-QASGILQLFASLLTPQSSCKAKVA 69
           L +  + + E +L+      L  +A+++ E ++ +  A  +  L   +L P +  K ++ 
Sbjct: 171 LLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQIL 230

Query: 70  NIIAEVAKNEF-MRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVD 128
           + +++V+K+   +    V+A +   ++  L  KD+ V       +  I   + E    V 
Sbjct: 231 SALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVV 290

Query: 129 QAGGAQIVIDHLRS 142
            AGG   VID + S
Sbjct: 291 NAGGVAAVIDCIGS 304



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 5/90 (5%)

Query: 470 LSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDL 529
           LS + +HS   ++ +T+V +G + HL  M  +    ++++ L AL+ ++   +  AE  +
Sbjct: 191 LSDIAKHSP--ELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVV 248

Query: 530 ESAKLVQILHRLLADERSAPEIKYNSMVLI 559
           E A++  ++   L D+     +K N+  LI
Sbjct: 249 E-AEIFPVVLTCLKDKDE--YVKKNASTLI 275


>gi|148227672 catenin (cadherin-associated protein), beta 1, 88kDa
           [Homo sapiens]
          Length = 781

 Score = 37.0 bits (84), Expect = 0.053
 Identities = 42/170 (24%), Positives = 73/170 (42%), Gaps = 24/170 (14%)

Query: 30  LLQALAQNNTETSEKIQASGILQLFASLLTPQS----SCKAKVANIIAEVAKNEFMRIPC 85
           +L+ L+  ++     ++A G+  L   L  P      +C   + N+     K E M    
Sbjct: 343 VLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGME--- 399

Query: 86  VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLC- 144
              GL+  LVQLL S D  V+      L N+  ++++ +  V Q GG + ++  +     
Sbjct: 400 ---GLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGD 456

Query: 145 --SITDPANEKLLTVFCGMLMNYSNENDSLQAQ---LINMGVIPTLVKLL 189
              IT+PA        C +    S   ++  AQ    ++ G +P +VKLL
Sbjct: 457 REDITEPA-------ICALRHLTSRHQEAEMAQNAVRLHYG-LPVVVKLL 498



 Score = 32.7 bits (73), Expect = 0.99
 Identities = 95/422 (22%), Positives = 159/422 (37%), Gaps = 60/422 (14%)

Query: 88  AGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSIT 147
           AG +  +V LLN  + + L  T   L  + Y + E +  +  +GG Q +++ +R+     
Sbjct: 276 AGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTY---- 331

Query: 148 DPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAA--LTEMCLVA 205
               EKLL     +L   S  + +  A +   G     ++ LG+H  + +  L + CL  
Sbjct: 332 --TYEKLLWTTSRVLKVLSVCSSNKPAIVEAGG-----MQALGLHLTDPSQRLVQNCLWT 384

Query: 206 FGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPL-AENDAIKLQLVEA 264
             NL++  + +E      +   LV+L     + +       +L+ L   N   K+ + + 
Sbjct: 385 LRNLSDAATKQE--GMEGLLGTLVQLLGSD-DINVVTCAAGILSNLTCNNYKNKMMVCQV 441

Query: 265 GLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQR---- 320
           G +E L+  V +  D    +DITE        +  L    S  +  E  + +V       
Sbjct: 442 GGIEALVRTVLRAGD---REDITE------PAICALRHLTSRHQEAEMAQNAVRLHYGLP 492

Query: 321 --VLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVED------ 372
             V    P ++  L  A    I N A   AN   + + G + +L+ LL R  +D      
Sbjct: 493 VVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTS 552

Query: 373 -GNVTVQ-----------HAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQF 420
            G    Q                AL  LA  V N+  +         ++ L S +  +Q 
Sbjct: 553 MGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQR 612

Query: 421 KLLGTLRMLIDAQ--AEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSK 478
              G L  L   +  AEA E  G    L E L        H+   G +    + L R S+
Sbjct: 613 VAAGVLCELAQDKEAAEAIEAEGATAPLTELL--------HSRNEGVATYAAAVLFRMSE 664

Query: 479 SK 480
            K
Sbjct: 665 DK 666



 Score = 30.0 bits (66), Expect = 6.4
 Identities = 31/113 (27%), Positives = 51/113 (45%), Gaps = 10/113 (8%)

Query: 78  NEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVI 137
           N+  ++  + +G    LV ++ +   E LL T   +  +       + A+ +AGG Q + 
Sbjct: 308 NQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALG 367

Query: 138 DHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLG 190
            HL      TDP+    L   C  L    N +D+   Q    G++ TLV+LLG
Sbjct: 368 LHL------TDPSQR--LVQNC--LWTLRNLSDAATKQEGMEGLLGTLVQLLG 410


>gi|148233338 catenin (cadherin-associated protein), beta 1, 88kDa
           [Homo sapiens]
          Length = 781

 Score = 37.0 bits (84), Expect = 0.053
 Identities = 42/170 (24%), Positives = 73/170 (42%), Gaps = 24/170 (14%)

Query: 30  LLQALAQNNTETSEKIQASGILQLFASLLTPQS----SCKAKVANIIAEVAKNEFMRIPC 85
           +L+ L+  ++     ++A G+  L   L  P      +C   + N+     K E M    
Sbjct: 343 VLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGME--- 399

Query: 86  VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLC- 144
              GL+  LVQLL S D  V+      L N+  ++++ +  V Q GG + ++  +     
Sbjct: 400 ---GLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGD 456

Query: 145 --SITDPANEKLLTVFCGMLMNYSNENDSLQAQ---LINMGVIPTLVKLL 189
              IT+PA        C +    S   ++  AQ    ++ G +P +VKLL
Sbjct: 457 REDITEPA-------ICALRHLTSRHQEAEMAQNAVRLHYG-LPVVVKLL 498



 Score = 32.7 bits (73), Expect = 0.99
 Identities = 95/422 (22%), Positives = 159/422 (37%), Gaps = 60/422 (14%)

Query: 88  AGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSIT 147
           AG +  +V LLN  + + L  T   L  + Y + E +  +  +GG Q +++ +R+     
Sbjct: 276 AGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTY---- 331

Query: 148 DPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAA--LTEMCLVA 205
               EKLL     +L   S  + +  A +   G     ++ LG+H  + +  L + CL  
Sbjct: 332 --TYEKLLWTTSRVLKVLSVCSSNKPAIVEAGG-----MQALGLHLTDPSQRLVQNCLWT 384

Query: 206 FGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPL-AENDAIKLQLVEA 264
             NL++  + +E      +   LV+L     + +       +L+ L   N   K+ + + 
Sbjct: 385 LRNLSDAATKQE--GMEGLLGTLVQLLGSD-DINVVTCAAGILSNLTCNNYKNKMMVCQV 441

Query: 265 GLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQR---- 320
           G +E L+  V +  D    +DITE        +  L    S  +  E  + +V       
Sbjct: 442 GGIEALVRTVLRAGD---REDITE------PAICALRHLTSRHQEAEMAQNAVRLHYGLP 492

Query: 321 --VLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVED------ 372
             V    P ++  L  A    I N A   AN   + + G + +L+ LL R  +D      
Sbjct: 493 VVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTS 552

Query: 373 -GNVTVQ-----------HAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQF 420
            G    Q                AL  LA  V N+  +         ++ L S +  +Q 
Sbjct: 553 MGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQR 612

Query: 421 KLLGTLRMLIDAQ--AEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSK 478
              G L  L   +  AEA E  G    L E L        H+   G +    + L R S+
Sbjct: 613 VAAGVLCELAQDKEAAEAIEAEGATAPLTELL--------HSRNEGVATYAAAVLFRMSE 664

Query: 479 SK 480
            K
Sbjct: 665 DK 666



 Score = 30.0 bits (66), Expect = 6.4
 Identities = 31/113 (27%), Positives = 51/113 (45%), Gaps = 10/113 (8%)

Query: 78  NEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVI 137
           N+  ++  + +G    LV ++ +   E LL T   +  +       + A+ +AGG Q + 
Sbjct: 308 NQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALG 367

Query: 138 DHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLG 190
            HL      TDP+    L   C  L    N +D+   Q    G++ TLV+LLG
Sbjct: 368 LHL------TDPSQR--LVQNC--LWTLRNLSDAATKQEGMEGLLGTLVQLLG 410


>gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa
           [Homo sapiens]
          Length = 781

 Score = 37.0 bits (84), Expect = 0.053
 Identities = 42/170 (24%), Positives = 73/170 (42%), Gaps = 24/170 (14%)

Query: 30  LLQALAQNNTETSEKIQASGILQLFASLLTPQS----SCKAKVANIIAEVAKNEFMRIPC 85
           +L+ L+  ++     ++A G+  L   L  P      +C   + N+     K E M    
Sbjct: 343 VLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGME--- 399

Query: 86  VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLC- 144
              GL+  LVQLL S D  V+      L N+  ++++ +  V Q GG + ++  +     
Sbjct: 400 ---GLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGD 456

Query: 145 --SITDPANEKLLTVFCGMLMNYSNENDSLQAQ---LINMGVIPTLVKLL 189
              IT+PA        C +    S   ++  AQ    ++ G +P +VKLL
Sbjct: 457 REDITEPA-------ICALRHLTSRHQEAEMAQNAVRLHYG-LPVVVKLL 498



 Score = 32.7 bits (73), Expect = 0.99
 Identities = 95/422 (22%), Positives = 159/422 (37%), Gaps = 60/422 (14%)

Query: 88  AGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSIT 147
           AG +  +V LLN  + + L  T   L  + Y + E +  +  +GG Q +++ +R+     
Sbjct: 276 AGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTY---- 331

Query: 148 DPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAA--LTEMCLVA 205
               EKLL     +L   S  + +  A +   G     ++ LG+H  + +  L + CL  
Sbjct: 332 --TYEKLLWTTSRVLKVLSVCSSNKPAIVEAGG-----MQALGLHLTDPSQRLVQNCLWT 384

Query: 206 FGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPL-AENDAIKLQLVEA 264
             NL++  + +E      +   LV+L     + +       +L+ L   N   K+ + + 
Sbjct: 385 LRNLSDAATKQE--GMEGLLGTLVQLLGSD-DINVVTCAAGILSNLTCNNYKNKMMVCQV 441

Query: 265 GLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQR---- 320
           G +E L+  V +  D    +DITE        +  L    S  +  E  + +V       
Sbjct: 442 GGIEALVRTVLRAGD---REDITE------PAICALRHLTSRHQEAEMAQNAVRLHYGLP 492

Query: 321 --VLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVED------ 372
             V    P ++  L  A    I N A   AN   + + G + +L+ LL R  +D      
Sbjct: 493 VVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTS 552

Query: 373 -GNVTVQ-----------HAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQF 420
            G    Q                AL  LA  V N+  +         ++ L S +  +Q 
Sbjct: 553 MGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQR 612

Query: 421 KLLGTLRMLIDAQ--AEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSK 478
              G L  L   +  AEA E  G    L E L        H+   G +    + L R S+
Sbjct: 613 VAAGVLCELAQDKEAAEAIEAEGATAPLTELL--------HSRNEGVATYAAAVLFRMSE 664

Query: 479 SK 480
            K
Sbjct: 665 DK 666



 Score = 30.0 bits (66), Expect = 6.4
 Identities = 31/113 (27%), Positives = 51/113 (45%), Gaps = 10/113 (8%)

Query: 78  NEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVI 137
           N+  ++  + +G    LV ++ +   E LL T   +  +       + A+ +AGG Q + 
Sbjct: 308 NQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALG 367

Query: 138 DHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLG 190
            HL      TDP+    L   C  L    N +D+   Q    G++ TLV+LLG
Sbjct: 368 LHL------TDPSQR--LVQNC--LWTLRNLSDAATKQEGMEGLLGTLVQLLG 410


>gi|15529984 armadillo repeat containing 6 [Homo sapiens]
          Length = 476

 Score = 36.6 bits (83), Expect = 0.069
 Identities = 56/228 (24%), Positives = 95/228 (41%), Gaps = 12/228 (5%)

Query: 387 NLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQAEAAE--QLGKNV 444
           N A  ++ + K L   + EA   FL +  P +  +L GTL  L        E   LG   
Sbjct: 239 NHAKMIVQENKGLKV-LIEATKAFLDN--PGILSELCGTLSRLAIRNEFCQEVVDLGGLS 295

Query: 445 KLVERLVEWC---EAKDHAGVMGESNRLLSALIRHSKSKDVIKTIVQSGGIKHLVTMATS 501
            LV  L + C   + +D +GV     ++LS L   + + DV   IV++GG + +V   T 
Sbjct: 296 ILVSLLAD-CNDHQMRDQSGVQELVKQVLSTLRAIAGNDDVKDAIVRAGGTESIVAAMTQ 354

Query: 502 EHVIMQ--NEALVALALIAALELGTAEKDLESAKLVQILHRLLADERSAPEIKYNSMVLI 559
                Q   ++  AL  +A  +   +   +E    V  L  + A  + A   K   M++ 
Sbjct: 355 HLTSPQVCEQSCAALCFLALRKPDNSRIIVEGGGAVAALQAMKAHPQKAGVQKQACMLIR 414

Query: 560 CALMGSECLHKEVQDLAFLDVVSKLRS-HENKSVAQQASLTEQRLTVE 606
             +   +   K + DL    ++ + RS H +     +A+L +    VE
Sbjct: 415 NLVAHGQAFSKPILDLGAEALIMQARSAHRDCEDVAKAALRDLGCHVE 462


>gi|7106299 ataxin 10 [Homo sapiens]
          Length = 475

 Score = 35.8 bits (81), Expect = 0.12
 Identities = 40/187 (21%), Positives = 80/187 (42%), Gaps = 18/187 (9%)

Query: 11  LKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQSSCKAKVAN 70
           LK+ + +  +D        LL  L +    T    +  G LQ+F  LL        +V +
Sbjct: 287 LKLASEEPPDDEEALATIRLLDVLCEMTVNT----ELLGYLQVFPGLLERVIDL-LRVIH 341

Query: 71  IIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQA 130
           +  +   N F    CV A     +  + N     ++    R +GN+CY + + +  V++ 
Sbjct: 342 VAGKETTNIFSNCGCVRAE--GDISNVANGFKSHLI----RLIGNLCYKNKDNQDKVNEL 395

Query: 131 GGAQIVIDHLRSLCSITD--PANEKLLTVFCGMLMNYSNENDSLQAQLINMGVI-PTLVK 187
            G  +++D+    C+I+D  P   + +      L   +++N  L A++   G+   +L+K
Sbjct: 396 DGIPLILDN----CNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLLK 451

Query: 188 LLGIHCQ 194
            +G   +
Sbjct: 452 KVGFEVE 458


>gi|4504901 karyopherin alpha 4 [Homo sapiens]
          Length = 521

 Score = 35.4 bits (80), Expect = 0.15
 Identities = 83/382 (21%), Positives = 147/382 (38%), Gaps = 51/382 (13%)

Query: 34  LAQNNTETSEKIQASGILQLFASLLTPQS--SCKAKVANIIAEVAKNEFMRIPCVDAGLI 91
           L+ +     + +  SGIL +    L      S + + A  +  +A     +   V     
Sbjct: 99  LSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNA 158

Query: 92  SPL-VQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAG---------GAQIVIDHLR 141
            PL ++LL+S  Q V  Q   ALGNI  D  + R  V   G            I I  LR
Sbjct: 159 VPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLR 218

Query: 142 S-------LCSITDPAN-----EKLLTVFCGML--------------MNYSNENDSLQAQ 175
           +       LC   DP       +++L   C ++              ++Y  +  + Q Q
Sbjct: 219 NVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQ 278

Query: 176 L-INMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFA-STNIAEELVKLFK 233
           + I+ G++P LV LL    Q   +    L A GN+      + Q   + +       L  
Sbjct: 279 MVIDSGIVPHLVPLLS--HQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLT 336

Query: 234 KQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGS 293
              E   +E ++ +    A N      +++A LV  ++ ++      DK D  T+ +   
Sbjct: 337 HPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLL------DKGDFGTQKEAAW 390

Query: 294 DLMVLLLLG-DESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCI- 351
            +  L + G  + +  L +      F  +L+   +   Q+ L G   I   A ++A  I 
Sbjct: 391 AISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIG 450

Query: 352 HMVDN-GIVEKLMDLLDRHVED 372
           ++++  G +EK+  L +   ED
Sbjct: 451 NLIEECGGLEKIEQLQNHENED 472


>gi|222144293 karyopherin alpha 1 [Homo sapiens]
          Length = 538

 Score = 33.9 bits (76), Expect = 0.45
 Identities = 26/104 (25%), Positives = 45/104 (43%), Gaps = 7/104 (6%)

Query: 86  VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCS 145
           +DAG+   LV+LL   D +V+    RA+GNI        +  D      +    L+SL  
Sbjct: 293 IDAGVCRRLVELLMHNDYKVVSPALRAVGNIV-------TGDDIQTQVILNCSALQSLLH 345

Query: 146 ITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLL 189
           +     E +    C  + N +  N +    +I+  + P L+ +L
Sbjct: 346 LLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISIL 389


>gi|146231975 catenin, delta 1 isoform 3A [Homo sapiens]
          Length = 832

 Score = 33.9 bits (76), Expect = 0.45
 Identities = 31/118 (26%), Positives = 54/118 (45%), Gaps = 10/118 (8%)

Query: 162 LMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFAS 221
           L +    ND ++  +  +  IP LV LL     +    E+ L A G L  +   ++Q   
Sbjct: 289 LQHLCYRNDKVKTDVRKLKGIPVLVGLL-----DHPKKEVHLGACGALKNISFGRDQDNK 343

Query: 222 TNIAE-----ELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIV 274
             I        LV+L +K  + D  E+I   L  L+ +D+IK+++V+  L     E++
Sbjct: 344 IAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVI 401


>gi|146231948 catenin, delta 1 isoform 3A [Homo sapiens]
          Length = 832

 Score = 33.9 bits (76), Expect = 0.45
 Identities = 31/118 (26%), Positives = 54/118 (45%), Gaps = 10/118 (8%)

Query: 162 LMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFAS 221
           L +    ND ++  +  +  IP LV LL     +    E+ L A G L  +   ++Q   
Sbjct: 289 LQHLCYRNDKVKTDVRKLKGIPVLVGLL-----DHPKKEVHLGACGALKNISFGRDQDNK 343

Query: 222 TNIAE-----ELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIV 274
             I        LV+L +K  + D  E+I   L  L+ +D+IK+++V+  L     E++
Sbjct: 344 IAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVI 401


>gi|146231994 catenin, delta 1 isoform 3A [Homo sapiens]
          Length = 832

 Score = 33.9 bits (76), Expect = 0.45
 Identities = 31/118 (26%), Positives = 54/118 (45%), Gaps = 10/118 (8%)

Query: 162 LMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFAS 221
           L +    ND ++  +  +  IP LV LL     +    E+ L A G L  +   ++Q   
Sbjct: 289 LQHLCYRNDKVKTDVRKLKGIPVLVGLL-----DHPKKEVHLGACGALKNISFGRDQDNK 343

Query: 222 TNIAE-----ELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIV 274
             I        LV+L +K  + D  E+I   L  L+ +D+IK+++V+  L     E++
Sbjct: 344 IAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVI 401


>gi|146231977 catenin, delta 1 isoform 3AC [Homo sapiens]
          Length = 838

 Score = 33.9 bits (76), Expect = 0.45
 Identities = 31/118 (26%), Positives = 54/118 (45%), Gaps = 10/118 (8%)

Query: 162 LMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFAS 221
           L +    ND ++  +  +  IP LV LL     +    E+ L A G L  +   ++Q   
Sbjct: 289 LQHLCYRNDKVKTDVRKLKGIPVLVGLL-----DHPKKEVHLGACGALKNISFGRDQDNK 343

Query: 222 TNIAE-----ELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIV 274
             I        LV+L +K  + D  E+I   L  L+ +D+IK+++V+  L     E++
Sbjct: 344 IAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVI 401


>gi|146231946 catenin, delta 1 isoform 3B [Homo sapiens]
          Length = 840

 Score = 33.9 bits (76), Expect = 0.45
 Identities = 31/118 (26%), Positives = 54/118 (45%), Gaps = 10/118 (8%)

Query: 162 LMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFAS 221
           L +    ND ++  +  +  IP LV LL     +    E+ L A G L  +   ++Q   
Sbjct: 289 LQHLCYRNDKVKTDVRKLKGIPVLVGLL-----DHPKKEVHLGACGALKNISFGRDQDNK 343

Query: 222 TNIAE-----ELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIV 274
             I        LV+L +K  + D  E+I   L  L+ +D+IK+++V+  L     E++
Sbjct: 344 IAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVI 401


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.359 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,601,926
Number of Sequences: 37866
Number of extensions: 711377
Number of successful extensions: 2261
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 58
Number of HSP's that attempted gapping in prelim test: 2113
Number of HSP's gapped (non-prelim): 130
length of query: 607
length of database: 18,247,518
effective HSP length: 108
effective length of query: 499
effective length of database: 14,157,990
effective search space: 7064837010
effective search space used: 7064837010
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.