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Search of human proteins with 154759273
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154759273 testis specific, 10 interacting protein [Homo
sapiens]
(556 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154759273 testis specific, 10 interacting protein [Homo sapiens] 1127 0.0
gi|22748943 hypothetical protein LOC145483 [Homo sapiens] 62 2e-09
gi|187936946 hypothetical protein LOC84140 [Homo sapiens] 55 2e-07
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens] 47 4e-05
gi|50962882 G patch domain containing 8 [Homo sapiens] 46 8e-05
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 45 1e-04
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 44 3e-04
gi|57864582 hornerin [Homo sapiens] 44 4e-04
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 44 5e-04
gi|148746195 trichohyalin [Homo sapiens] 43 9e-04
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 42 0.002
gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo s... 42 0.002
gi|7705415 hook homolog 1 [Homo sapiens] 39 0.010
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 39 0.010
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 39 0.010
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 39 0.010
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 39 0.010
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 39 0.010
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 39 0.010
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 39 0.010
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 39 0.010
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 39 0.016
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 39 0.016
gi|92091575 coiled-coil domain containing 57 [Homo sapiens] 38 0.021
gi|224809410 Homer, neuronal immediate early gene, 3 isoform 2 [... 38 0.028
gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [... 38 0.028
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 37 0.036
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 37 0.036
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 37 0.036
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 37 0.036
>gi|154759273 testis specific, 10 interacting protein [Homo sapiens]
Length = 556
Score = 1127 bits (2915), Expect = 0.0
Identities = 556/556 (100%), Positives = 556/556 (100%)
Query: 1 MGQDTDMLNTYQQLVRTPSVRPGQDVRLQAPGTRTGLLKLLSTVSQDKQGCLGSGDGVPN 60
MGQDTDMLNTYQQLVRTPSVRPGQDVRLQAPGTRTGLLKLLSTVSQDKQGCLGSGDGVPN
Sbjct: 1 MGQDTDMLNTYQQLVRTPSVRPGQDVRLQAPGTRTGLLKLLSTVSQDKQGCLGSGDGVPN 60
Query: 61 QDLQQRSQSSRQTAKKDRKPRGQSKKGQGSEESEDHFPLLPRKPSFPFQWAWESIATDVR 120
QDLQQRSQSSRQTAKKDRKPRGQSKKGQGSEESEDHFPLLPRKPSFPFQWAWESIATDVR
Sbjct: 61 QDLQQRSQSSRQTAKKDRKPRGQSKKGQGSEESEDHFPLLPRKPSFPFQWAWESIATDVR 120
Query: 121 AVLQPSSPTPGHQALPMPSSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGG 180
AVLQPSSPTPGHQALPMPSSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGG
Sbjct: 121 AVLQPSSPTPGHQALPMPSSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGG 180
Query: 181 VSIPTGKGELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRR 240
VSIPTGKGELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRR
Sbjct: 181 VSIPTGKGELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRR 240
Query: 241 GSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSSPSFN 300
GSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSSPSFN
Sbjct: 241 GSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSSPSFN 300
Query: 301 NLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYAS 360
NLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYAS
Sbjct: 301 NLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYAS 360
Query: 361 GYDETFVSANLPNRTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLA 420
GYDETFVSANLPNRTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLA
Sbjct: 361 GYDETFVSANLPNRTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLA 420
Query: 421 AYAPRGSRGPGAAQRKLEELRRQERQRFAEYQAELQGIQHRVQARPFLFQQAMQANARLT 480
AYAPRGSRGPGAAQRKLEELRRQERQRFAEYQAELQGIQHRVQARPFLFQQAMQANARLT
Sbjct: 421 AYAPRGSRGPGAAQRKLEELRRQERQRFAEYQAELQGIQHRVQARPFLFQQAMQANARLT 480
Query: 481 VTRRFSQVLSALGLDEEQLLSEAGKVDREGTPRKPRSHRSMGVRMEHSPQRPPRTEPTGS 540
VTRRFSQVLSALGLDEEQLLSEAGKVDREGTPRKPRSHRSMGVRMEHSPQRPPRTEPTGS
Sbjct: 481 VTRRFSQVLSALGLDEEQLLSEAGKVDREGTPRKPRSHRSMGVRMEHSPQRPPRTEPTGS 540
Query: 541 QPDRHYNPSLDPECSP 556
QPDRHYNPSLDPECSP
Sbjct: 541 QPDRHYNPSLDPECSP 556
>gi|22748943 hypothetical protein LOC145483 [Homo sapiens]
Length = 647
Score = 61.6 bits (148), Expect = 2e-09
Identities = 47/179 (26%), Positives = 88/179 (49%), Gaps = 11/179 (6%)
Query: 378 KRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKL 437
KR+ A RS L+ + + E Q E+ R ++Q + + V A P S + KL
Sbjct: 461 KRESAVRSALEK-KNKADESIQWLEIHRKKSQAMSKSVTLRAKAMDPHKSLEE-VFKAKL 518
Query: 438 EELRRQERQRFAEYQAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQVLSALGLDEE 497
+E R +R+R EY+ EL+ ++ R+Q RP+LF+Q + A+ + + L GL+E+
Sbjct: 519 KENRNNDRKRAKEYKKELEEMKQRIQTRPYLFEQVAKDLAKKEAEQWYLDTLKQAGLEED 578
Query: 498 QLLSEAGKVDREGTPRKPRSHRSMGVRMEHSPQRPPRTEPTGSQPDRHYNPSLDPECSP 556
+ ++ +GT R+ + +++ P+ T+ + P++ SL+ SP
Sbjct: 579 FVRNKG-----QGT----RAVQEKETKIKDFPRFQETTKLSIRDPEQGLEGSLEQPASP 628
>gi|187936946 hypothetical protein LOC84140 [Homo sapiens]
Length = 660
Score = 55.1 bits (131), Expect = 2e-07
Identities = 28/80 (35%), Positives = 48/80 (60%), Gaps = 3/80 (3%)
Query: 430 PGAAQRKLEE-LRRQERQRFAEYQAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQV 488
P + R E+ +R+ E++R EYQ EL+ + +++ RP LF++ Q NAR+ + +S
Sbjct: 516 PTVSSRGREQAVRKSEKERMREYQRELEEREEKLKKRPLLFERVAQKNARMAAEKHYSNT 575
Query: 489 LSALGLDEE--QLLSEAGKV 506
L ALG+ +E ++GKV
Sbjct: 576 LKALGISDEFVSKKGQSGKV 595
>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
Length = 715
Score = 47.4 bits (111), Expect = 4e-05
Identities = 118/587 (20%), Positives = 206/587 (35%), Gaps = 123/587 (20%)
Query: 16 RTPSVRPGQDVRLQAPGTRTGLLKLLSTVSQDKQGCLGSGDGVPNQDLQQRSQSS-RQTA 74
R+PS R R++ G R G+ + T + ++G G G P ++RS S R +
Sbjct: 134 RSPS-RASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLS 192
Query: 75 KKDRKPRGQSKKGQGS--------------------EESEDHFPLLPRK---------PS 105
KK +P G S G+ S E+S++ P RK PS
Sbjct: 193 KKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPS 252
Query: 106 FPFQWAWESIATDVRAVLQPSSPTPGHQALPMPSSFSQRQSRRKSTANLPEAHGCCWKTE 165
++ +++ V++ Q S+ + S R +K T + +H WK
Sbjct: 253 REKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHS--WKRN 310
Query: 166 AQNLKARQQLGAWGGVSIPTGKGELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEA 225
++R + G L GR S S S + Q QS
Sbjct: 311 HSRARSRTRKGI--------------------LSQMGRHSQSRSHSKGKSQNQS------ 344
Query: 226 ERGLSSGVLPQRPRRG-------SISEEEQFSEATEEAEEGEHRTPCRRRAGCQRKGQIS 278
+ PRRG + S+E S + ++E +HR R R
Sbjct: 345 ----------RTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGR----- 389
Query: 279 GEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLDCGPQK 338
++ + + S+ SP+ R R +A++ R + DC +
Sbjct: 390 -SQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARD-------RSRSRSPNKARDCSRSR 441
Query: 339 LPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEATRSLLQAWERQRQE-- 396
P+K + S + ++ +R+ +K ++ +RS + ER +
Sbjct: 442 SPYKARDRSRSRSPNKARDHSR------------SRSPNKARDRSRSRSPSKERDHSQLG 489
Query: 397 -ERQQAELRRARTQHVQRQVAHCLAAYAPRG---SRGPG-AAQRKLEELRRQERQRFAEY 451
++ + RR+R+ +RQ ++ R SR P QR+ +ER R ++
Sbjct: 490 SPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDR-SQS 548
Query: 452 QAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQVLSALGLDEEQLLSEAGKVDREGT 511
++ + +HR P ++ RR+ + + SE R +
Sbjct: 549 RSPSEEREHRQSRSP----------SKERDRRRWRSPSKERERRQSRSSSEERDHSRSRS 598
Query: 512 PRKPRSH---RSMGVRMEHSPQRPPRTEPTGSQPDRHYNPSLDPECS 555
P K + R+ HS R P E SQ R + DP S
Sbjct: 599 PNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQ-SRTSSKESDPSQS 644
>gi|50962882 G patch domain containing 8 [Homo sapiens]
Length = 1502
Score = 46.2 bits (108), Expect = 8e-05
Identities = 92/421 (21%), Positives = 145/421 (34%), Gaps = 78/421 (18%)
Query: 54 SGDGVPNQDLQQRSQSSRQTAKKDRKPRGQSKKGQGSEESEDHFPLLPRKPSFPFQWAWE 113
SG ++ ++ +SS+ K +S K + E+S+ +K
Sbjct: 669 SGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNK-------S 721
Query: 114 SIATDVRAVLQPSSPTPGHQALPMPSSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQ 173
S D +P P G A P +Q S+R+S LP G K +
Sbjct: 722 SAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRS---LPAEEGSSGKKDE------- 771
Query: 174 QLGAWGGVSIPTG----KGELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGL 229
G G S G KGEL PPS Q RR G+ +S + Q +E
Sbjct: 772 --GGGGSSSQDHGGRKHKGEL---PPSSCQ---RRAGTKRSSRSSHRSQPSSGDEDSDDA 823
Query: 230 SSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAG--------CQRKGQISGEE 281
SS L Q+ Q+SE EE + G + R R+G +R S +
Sbjct: 824 SSHRLHQK-------SPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDA 876
Query: 282 ASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDL------EKLHRQLQRD---- 331
+SD+ Q S S+++ R R ++ D K H+ D
Sbjct: 877 SSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYS 936
Query: 332 LDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHK----------RQE 381
L C + ++ + S+ G++ +S + + T H R
Sbjct: 937 LSCSQSRS--RSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSR 994
Query: 382 ATRSLLQ-------AWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQ 434
+TRS Q +W + EER R++ + Q H R RG G +
Sbjct: 995 STRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYF-----RSGRGEGPGK 1049
Query: 435 R 435
+
Sbjct: 1050 K 1050
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 45.4 bits (106), Expect = 1e-04
Identities = 63/279 (22%), Positives = 106/279 (37%), Gaps = 44/279 (15%)
Query: 64 QQRSQSSRQTAKKDRK-----PRGQSKKGQGSEESEDHFPLLPRKPSFPFQWAWESIATD 118
+++S +R+ + K R+ PR + SE S P +PS P +W A+
Sbjct: 426 KEKSALARERSLKKRQSLPASPRARLSASTASELS----PKSKARPSSP-STSWHRPASP 480
Query: 119 VRAVLQPSSPTPGHQALPMP-------SSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKA 171
SP PGH P P +S R R++ P A G K++++ +
Sbjct: 481 C------PSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRAS 534
Query: 172 RQQLGAWGGVSIPTGKGELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSS 231
++ A P+ PP Q P P + L S A +
Sbjct: 535 NEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAV------LTSPPAP------AP 582
Query: 232 GVLPQRPRRGSISEEEQ---FSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEV 288
V P +P G+ EE +E +A E R RR +R ++ E+ + E E
Sbjct: 583 PVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEA 642
Query: 289 QGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQ 327
+ + + + RRR+ ++ R K + E+L +Q
Sbjct: 643 RAEREAEA------RRREEQEAREKAQAEQEEQERLQKQ 675
Score = 39.7 bits (91), Expect = 0.007
Identities = 47/191 (24%), Positives = 75/191 (39%), Gaps = 21/191 (10%)
Query: 379 RQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLE 438
R+EATR L + + R++ ++ + RR + + +R LA A + A+R+ E
Sbjct: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREE 655
Query: 439 ELRRQERQRFAEYQAELQGIQHRVQA------------RPFLFQQAMQANARLTVTRRFS 486
+ R++ Q E Q LQ + +A R FQQ Q R +R
Sbjct: 656 QEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQ--QEQERQERRKRLE 713
Query: 487 QVLSALGLDE------EQLLSEAGKVDREGTPRKPRSHRSMGVRMEH-SPQRPPRTEPTG 539
+++ E +Q EA P K RS G++ E + P EP
Sbjct: 714 EIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQW 773
Query: 540 SQPDRHYNPSL 550
S P + SL
Sbjct: 774 SLPSKELPASL 784
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 44.3 bits (103), Expect = 3e-04
Identities = 56/257 (21%), Positives = 111/257 (43%), Gaps = 25/257 (9%)
Query: 236 QRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGS 295
++P+RGSI E + E+ E + T + GQIS EE E E + QGS
Sbjct: 196 EKPKRGSIGENQVEVMVEEKTTESQEETVVM----SLKNGQISSEEPKQEEE---REQGS 248
Query: 296 SPSFNNLRRRQWRKTRAKELQGPWDLEKLHR-QLQRDLDCGPQKLPWKTLRAAFQASKRN 354
++ + + K RA+ + + E+ R + ++D + RA +A +
Sbjct: 249 DEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADE-------RARIEAEE-- 299
Query: 355 GKAYASGYDETFVSANLPNRTFHKRQEATRSLLQAWERQRQEERQ--QAELRRARTQHVQ 412
KA A + R KR R ++ E++ EERQ + E +RA + +
Sbjct: 300 -KAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 358
Query: 413 RQVAHCLAAYAPRGSRGPGAAQRKLEELRRQ---ERQRFAEYQAELQG--IQHRVQARPF 467
+ AA + +R + K+EE +R E ++ A + +++G ++ +++ +
Sbjct: 359 IKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWV 418
Query: 468 LFQQAMQANARLTVTRR 484
++A + + V ++
Sbjct: 419 NEKKAQEDKLQTAVLKK 435
>gi|57864582 hornerin [Homo sapiens]
Length = 2850
Score = 43.9 bits (102), Expect = 4e-04
Identities = 48/172 (27%), Positives = 70/172 (40%), Gaps = 11/172 (6%)
Query: 126 SSPTPGHQALPMPSSFSQRQSRRKSTANLPEAHGCCWKTEAQNL-KARQQLGAWGGVSIP 184
S + GH S S R R+ S+A ++G Q+L +R G+ S
Sbjct: 485 SGHSSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQHGSGSRQSLGHSRHGSGSGQSPSPS 544
Query: 185 TGKGELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSIS 244
G+ E GS S G GSG +S + G E+ G SSG+ Q R G S
Sbjct: 545 RGRHESGSRQSSSYGPHGY--GSGRSSSR-------GPYESGSGHSSGLGHQESRSGQSS 595
Query: 245 EEEQF-SEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGS 295
Q S + + G+H + + + C + G SG+ +S G SQ S
Sbjct: 596 GYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSS 647
Score = 40.0 bits (92), Expect = 0.006
Identities = 41/158 (25%), Positives = 63/158 (39%), Gaps = 9/158 (5%)
Query: 139 SSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELGSEPPSGL 198
S S R + S++ ++G Q+L Q G+ G S +G GS
Sbjct: 964 SGQSSRSEQHGSSSGSSSSYGQHGSGSRQSL-GHGQHGSGSGQSPSPSRGRHGSGSGQSS 1022
Query: 199 QLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQF-SEATEEAE 257
R GSG +S + G E+ G SSG+ + R G S Q S + +
Sbjct: 1023 SYGPYRSGSGWSSSR-------GPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSST 1075
Query: 258 EGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGS 295
G+H + + + C + G SG+ +S G SQ S
Sbjct: 1076 HGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSS 1113
Score = 38.5 bits (88), Expect = 0.016
Identities = 41/158 (25%), Positives = 62/158 (39%), Gaps = 9/158 (5%)
Query: 139 SSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELGSEPPSGL 198
S S R R S++ ++G Q+L Q G+ G S +G GS
Sbjct: 2374 SGQSSRGERHGSSSGSSSSYGQHGSGSRQSL-GHGQHGSGSGQSPSPSRGRHGSGSGQSS 2432
Query: 199 QLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQF-SEATEEAE 257
GSG +S + G E+ G SSG+ + R G S Q S + +
Sbjct: 2433 SYSPYGSGSGWSSSR-------GPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSST 2485
Query: 258 EGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGS 295
G+H + + + C + G SG+ +S G SQ S
Sbjct: 2486 HGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSS 2523
Score = 36.6 bits (83), Expect = 0.062
Identities = 40/158 (25%), Positives = 62/158 (39%), Gaps = 9/158 (5%)
Query: 139 SSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELGSEPPSGL 198
S S R + S++ ++G Q+L Q G+ G S +G GS
Sbjct: 1904 SGQSSRGEQHGSSSGSSSSYGQHGSGSRQSL-GHGQHGSGSGQSPSPSRGRHGSGSGQSS 1962
Query: 199 QLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQF-SEATEEAE 257
GSG +S + G E+ G SSG+ + R G S Q S + +
Sbjct: 1963 SYGPYGSGSGWSSSR-------GPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSST 2015
Query: 258 EGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGS 295
G+H + + + C + G SG+ +S G SQ S
Sbjct: 2016 HGQHGSASGQSSSCGQHGASSGQSSSHGQHGSGSSQSS 2053
Score = 36.2 bits (82), Expect = 0.081
Identities = 40/158 (25%), Positives = 61/158 (38%), Gaps = 9/158 (5%)
Query: 139 SSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELGSEPPSGL 198
S S R R S++ ++G Q+L Q G+ G S +G GS
Sbjct: 1434 SGQSSRGERHGSSSGSSSSYGQHGSGSRQSL-GHGQHGSGSGQSPSPSRGRHGSGSGQSS 1492
Query: 199 QLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQF-SEATEEAE 257
GSG +S + G E+ SSG+ + R G S Q S + +
Sbjct: 1493 SYSPYGSGSGWSSSR-------GPYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSST 1545
Query: 258 EGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGS 295
G+H + + + C + G SG+ +S G SQ S
Sbjct: 1546 HGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSS 1583
Score = 35.0 bits (79), Expect = 0.18
Identities = 44/191 (23%), Positives = 75/191 (39%), Gaps = 21/191 (10%)
Query: 126 SSPTPGHQALPMPSSFSQRQSRRKSTANLPEAHGCCWKTEAQNL------------KARQ 173
SS + G++ S S R + S++ L ++G Q+ +R
Sbjct: 720 SSHSSGYRKHGSRSGQSSRSEQHGSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPSRV 779
Query: 174 QLGAWGGVSIPTGKGELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGV 233
+ G+ G S + G+ GS GSG AS G ++ G +SG
Sbjct: 780 RHGSSSGHS--SSHGQHGSGTSCSSSCGHYESGSGQASGFGQHESGSGQGYSQHGSASGH 837
Query: 234 LPQRPRRGSISEE-----EQFSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEV 288
+ R GS S + + S + + + G+H + +G R G SG ++ G+
Sbjct: 838 FSSQGRHGSTSGQSSSSGQHDSSSGQSSSYGQHESASHHASGRGRHGSGSG-QSPGHGQ- 895
Query: 289 QGQSQGSSPSF 299
+G G SPS+
Sbjct: 896 RGSGSGQSPSY 906
Score = 35.0 bits (79), Expect = 0.18
Identities = 40/159 (25%), Positives = 58/159 (36%), Gaps = 11/159 (6%)
Query: 139 SSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELGSEPPSGL 198
SS S R+ S + HG Q +Q ++G +G+ + SGL
Sbjct: 2519 SSQSSGYGRQGSGSGQSPGHG-------QRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGL 2571
Query: 199 QLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQF-SEATEEAE 257
G G G Q S + G SSG R G S E+ S + +
Sbjct: 2572 ---GESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSH 2628
Query: 258 EGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSS 296
G+H + R+ +G R+G SG+ S G SS
Sbjct: 2629 YGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSSS 2667
Score = 34.3 bits (77), Expect = 0.31
Identities = 40/159 (25%), Positives = 57/159 (35%), Gaps = 11/159 (6%)
Query: 139 SSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELGSEPPSGL 198
SS S R+ S + HG Q +Q ++G +G+ + SGL
Sbjct: 1109 SSQSSGYGRQGSGSGQSPGHG-------QRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGL 1161
Query: 199 QLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQF-SEATEEAE 257
G G G Q S + G SSG R G S E+ S + +
Sbjct: 1162 ---GESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSH 1218
Query: 258 EGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSS 296
G+H + R+ +G R+G SG S G SS
Sbjct: 1219 YGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGLGHSSS 1257
Score = 33.9 bits (76), Expect = 0.40
Identities = 65/261 (24%), Positives = 89/261 (34%), Gaps = 18/261 (6%)
Query: 53 GSGDGVPNQDLQQRSQSSR-----QTAKKDRKPRGQSKKGQGSEESEDHFPL---LPRKP 104
GS G ++ + RS S Q R+ G ++G GS +S H
Sbjct: 261 GSRSGQSSRGERHRSSSGSSSSYGQHGSGSRQSLGHGRQGSGSRQSPSHVRHGSGSGHSS 320
Query: 105 SFPFQWAWESIATDVRAVLQPSSPTPGHQALPMPSSFSQRQSRRKSTANLPEAHGCCWKT 164
S + S + S T G S S S+ S + + G T
Sbjct: 321 SHGQHGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQSSGYSKHGSGSGHSSSQGQHGST 380
Query: 165 EAQNLKARQQLGAWGGVSIPTGKGELGSEPPSGLQL----PGRRPGSGSASDKQVQLQSL 220
Q + Q G+ S G+ E S SG G+ PG G Q S
Sbjct: 381 SGQASSSGQH-GSSSRQSSSYGQHESASRHSSGRGQHSSGSGQSPGHGQRGSGSGQSPSS 439
Query: 221 GAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEG--EHRTPCRRRAGCQRKGQIS 278
G G SS P G S E++ E G +H + +G + G S
Sbjct: 440 GQHGTGFGRSSSSGPYVSGSG-YSSGFGHHESSSEHSSGYTQHGSGSGHSSGHGQHGSRS 498
Query: 279 GEEASDEGEVQGQSQGSSPSF 299
G+ S GE QG S GSS S+
Sbjct: 499 GQ--SSRGERQGSSAGSSSSY 517
Score = 33.9 bits (76), Expect = 0.40
Identities = 38/147 (25%), Positives = 55/147 (37%), Gaps = 17/147 (11%)
Query: 176 GAWGGVSIPTGKGELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLP 235
G+ G S +G+ GS SG G + SG +S + G SS
Sbjct: 910 GSGSGRSSSSGRHGSGSGQSSGF---GHKSSSGQSS-------GYTQHGSGSGHSSSYEQ 959
Query: 236 QRPRRGSISEEEQF-SEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQG 294
R G S EQ S + + G+H + R+ G + G SG+ S G G
Sbjct: 960 HGSRSGQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSG 1019
Query: 295 SSPSFNNLRRRQ-WRKTRAKELQGPWD 320
S S+ R W +R GP++
Sbjct: 1020 QSSSYGPYRSGSGWSSSR-----GPYE 1041
Score = 32.7 bits (73), Expect = 0.90
Identities = 70/306 (22%), Positives = 102/306 (33%), Gaps = 35/306 (11%)
Query: 21 RPGQDVRLQAPGTRTGLLKLLSTVSQDKQGCLGSGDGVPNQDLQQRSQSSRQTAK-KDRK 79
R GQ R + G+ +G S + G GSG + +Q S S ++ +
Sbjct: 2139 RSGQSSRGERHGSSSG--------SSSRYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGS 2190
Query: 80 PRGQSKK----GQGSEESEDHFPLLPRKPSFPFQWAWESIATDVRAVLQPSSPTPGHQAL 135
G S G GS S P R ES + A Q S + +
Sbjct: 2191 GSGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQ 2250
Query: 136 PMPSSFSQRQS---RRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELGS 192
S S + S + S+ +HG +Q+ QQ G+ G S G+ GS
Sbjct: 2251 GQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQ-GSGSGQSPSRGRHGSGS 2309
Query: 193 EPPSGLQLPGRRPGSGSASDKQV----QLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQ 248
S G G S+S + Q G E+ SSG G S EQ
Sbjct: 2310 GHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQ 2369
Query: 249 FSEATEEAEEGE--------------HRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQG 294
+ ++ GE H + R+ G + G SG+ S G G
Sbjct: 2370 HGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSG 2429
Query: 295 SSPSFN 300
S S++
Sbjct: 2430 QSSSYS 2435
Score = 32.0 bits (71), Expect = 1.5
Identities = 38/158 (24%), Positives = 52/158 (32%), Gaps = 29/158 (18%)
Query: 171 ARQQLGAWGGVSIPTGKGELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLS 230
A Q G+ G G+ S S G G S+ + S + G
Sbjct: 1296 AYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSSQSSGYGRHGAG 1355
Query: 231 SGVLPQRPRRG------------------SISEEEQFSEATEEAEEGEHRTPCRRRAGCQ 272
SG P R R G S S S + + + G H + + +GC
Sbjct: 1356 SGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGCT 1415
Query: 273 RKGQISGEEASDE-----------GEVQGQSQGSSPSF 299
+ G SG +S E GE G S GSS S+
Sbjct: 1416 QHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSY 1453
Score = 32.0 bits (71), Expect = 1.5
Identities = 71/306 (23%), Positives = 102/306 (33%), Gaps = 37/306 (12%)
Query: 21 RPGQDVRLQAPGTRTGLLKLLSTVSQDKQGCLGSGDGVPNQDLQQRSQSSRQTAKKDRKP 80
R GQ R + G+ S+ S + G GSG + +Q S S Q+ + R
Sbjct: 1669 RSGQSSRGERHGS--------SSRSSSRYGQHGSGSRQSSGHGRQGSGSG-QSPSRGRHG 1719
Query: 81 RG------QSKKGQGSEESEDHFPLLPRKPSFPFQWAWESIATDVRAVLQPSSPTPGHQA 134
G + G GS S P R ES + A Q S + +
Sbjct: 1720 SGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCS 1779
Query: 135 LPMPSSFSQRQS---RRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELG 191
S S + S + S+ +HG +Q+ QQ G+ G S G+ G
Sbjct: 1780 QGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQ-GSGSGQSPSRGRHGSG 1838
Query: 192 SEPPSGLQLPGRRPGSGSASDKQV----QLQSLGAEEAERGLSSGVLPQRPRRGSISEEE 247
S S G G S+S + Q G E+ SSG G S E
Sbjct: 1839 SGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYE 1898
Query: 248 QFSEATEEAEEGE--------------HRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQ 293
Q + ++ GE H + R+ G + G SG+ S G
Sbjct: 1899 QHGSRSGQSSRGEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGS 1958
Query: 294 GSSPSF 299
G S S+
Sbjct: 1959 GQSSSY 1964
Score = 31.2 bits (69), Expect = 2.6
Identities = 35/135 (25%), Positives = 52/135 (38%), Gaps = 5/135 (3%)
Query: 171 ARQQLGAWGGVSIPTGKGELGS--EPPSGLQLPGRRPGSGSASDKQVQLQSLGAEE--AE 226
+R + G+ G S G+ GS SG G SG + QS G + +
Sbjct: 1361 SRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGCTQHGSG 1420
Query: 227 RGLSSGVLPQRPRRGSISEEEQF-SEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDE 285
G SS R G S E+ S + + G+H + R+ G + G SG+ S
Sbjct: 1421 SGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPS 1480
Query: 286 GEVQGQSQGSSPSFN 300
G G S S++
Sbjct: 1481 RGRHGSGSGQSSSYS 1495
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 43.5 bits (101), Expect = 5e-04
Identities = 60/282 (21%), Positives = 103/282 (36%), Gaps = 41/282 (14%)
Query: 56 DGVPNQDLQQRSQSSRQTAKKDRKPRGQSKKGQGSEESEDHFPLLPRKPSFPFQWAWESI 115
D VP ++RS S+ KD PR S++ + P L P + +
Sbjct: 1408 DAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSS-----PGLRDGSGTPSRHSLSGS 1462
Query: 116 ATDVRAVLQPSSPTPGH---QALPMPSSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKAR 172
+ ++ + P +P+ G + P P + Q R + + PE + C + + +
Sbjct: 1463 SPGMKDI--PRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSE 1520
Query: 173 QQLGAWGGVSIPTGK-------GELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEA 225
+ P G+ EL +P + P R S S+ D + + ++ + +
Sbjct: 1521 SSVDQKTVARTPLGQRSRSGSSQELDVKPSAS---PQERSESDSSPDSKAKTRTPLRQRS 1577
Query: 226 ERGLS------SGVLPQRPRRGSISEEEQFSEATEEAEEGEHRT-----------PCRRR 268
G S S + P+R R GS E + A A+ G + P R R
Sbjct: 1578 RSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSR 1637
Query: 269 AGCQRKGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKT 310
+G KG+ S EG +S P + RR R +
Sbjct: 1638 SGSSSKGR----GPSPEGSSSTESSPEHPPKSRTARRGSRSS 1675
Score = 36.2 bits (82), Expect = 0.081
Identities = 115/518 (22%), Positives = 178/518 (34%), Gaps = 79/518 (15%)
Query: 54 SGDGVPNQDLQQ-RSQSS----RQTAKKDRKPRGQS-KKGQGSEESEDHFPLLPRKPSFP 107
S D + D + RS+S+ TA R P S ++G+G + ++PS P
Sbjct: 265 SADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSP 324
Query: 108 FQWAWESIATDVRAVLQPSSPTPG------HQALPMPSSFSQRQSRRKS----TANLPEA 157
A QPSSP ++ PS +R S T L E
Sbjct: 325 -----------ETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAER 373
Query: 158 HGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELGSEPPSGLQLPGRRPGSGSASDKQVQL 217
HG + A +++ + S + S P S +LP S Q
Sbjct: 374 HGGSPQPLATTPLSQEPVNPPSEASPTRDR----SPPKSPEKLPQSSSSESSPPSPQPTK 429
Query: 218 QSLGAEEAERGLSSGVLPQRPRRGSISE-EEQFSEATEEAEEGEHRTPCRRRAGCQRKGQ 276
S A + P R S S + S + ++ TP RR
Sbjct: 430 VSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRM-------- 481
Query: 277 ISGEEASDEGEVQGQSQGSSPS---FNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLD 333
G S +G+S+ +P+ + R QWR++R+ + G + +R
Sbjct: 482 --GRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWG-----RSRSPQRRGRS 534
Query: 334 CGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEATRSLLQAW--- 390
PQ+ W R ++R G++ ++ + H R ATR ++
Sbjct: 535 RSPQRPGWSRSRN----TQRRGRSRSARRGRS-----------HSRSPATRGRSRSRTPA 579
Query: 391 ERQRQEERQQAELR-RARTQHVQRQVAHCLAAYAPRGSRGPGAAQ-RKLEELRRQERQRF 448
R R R A R R+RT +R + A SR P + R +RR+ R R
Sbjct: 580 RRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRS 639
Query: 449 -AEYQAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQVLSALGLDEEQLLSEAGKVD 507
A + + R A + +R R S G + + G+
Sbjct: 640 PARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRS------GRSRSRTPARRGR-S 692
Query: 508 REGTPRKPRSHRSMGVRMEHSPQR-PPRTEPTGSQPDR 544
R TPR+ RS VR S R P R +GS +R
Sbjct: 693 RSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSER 730
Score = 36.2 bits (82), Expect = 0.081
Identities = 80/385 (20%), Positives = 134/385 (34%), Gaps = 36/385 (9%)
Query: 184 PTGKGELGSEPPSGLQLPGR--RPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRG 241
P E+ S P S + GR R S S + + +S A+RG S P + R
Sbjct: 447 PGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTK-RGH 505
Query: 242 SISEEEQFSEATEEAEEGEHRTPCRR-------RAG------CQRKGQIS----GEEASD 284
S S Q+ + G R+P RR R G QR+G+ G S
Sbjct: 506 SRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSR 565
Query: 285 EGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHR---QLQRDLDCGPQKLPW 341
+G+S+ +P+ R + R + P R + R P +
Sbjct: 566 SPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRS 625
Query: 342 KTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEATRSLLQAWERQRQEERQQA 401
+T + S+ A SG + A RS + R+ R +
Sbjct: 626 RTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRT 685
Query: 402 ELRR----ARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEELRRQERQRFAEYQAELQG 457
RR +RT R + L SR P R R+ + R ++ ++
Sbjct: 686 PARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRS---- 741
Query: 458 IQHRVQARPFLFQQAMQANARLTVTRRFSQVLSALGLDEEQLLSEAGKVDREGTPRKPRS 517
R + P + + + + +++ S+ S L L + LS + ++ + PR
Sbjct: 742 ---RSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSL--RRSLSGSSPCPKQKSQTPPRR 796
Query: 518 HRSMGVRMEHSPQRPPRTEPTGSQP 542
RS + + + PPR + S P
Sbjct: 797 SRSGSSQPKAKSRTPPRRSRSSSSP 821
Score = 32.3 bits (72), Expect = 1.2
Identities = 108/539 (20%), Positives = 181/539 (33%), Gaps = 104/539 (19%)
Query: 65 QRSQSSRQTAKKDRKPRGQSKKGQGSEESEDHFPLLPRKPSFPFQWAWESIA-------- 116
+RS+S KD KPR + GS+ S + P P + P + S +
Sbjct: 1594 RRSRSGSSPEVKD-KPRAAPRAQSGSDSSPE--PKAPAPRALPRRSRSGSSSKGRGPSPE 1650
Query: 117 ----TDVRAVLQPSSPTP--GHQALPMPSSFSQRQSRRKSTANLPEAHGCCWKTEAQNLK 170
T+ P S T G ++ P P + S+ RR+S+ + PE K
Sbjct: 1651 GSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPEL----------TRK 1700
Query: 171 ARQQLGAWGGVSIPTGKGELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEE--AERG 228
AR + S P + + P S S ++ + S + + RG
Sbjct: 1701 ARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRG 1760
Query: 229 LSSGVLPQRPRRG-SISEEEQFSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGE 287
S P+ +R S S E+ G ++ RRR + + +++ G
Sbjct: 1761 RSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGY 1820
Query: 288 VQGQSQGSSPSFNNLRRRQWR---------KTRAKELQGPWDLEK------LHRQ----- 327
S + RRR+ R ++R++ PW + HR+
Sbjct: 1821 HSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRT 1880
Query: 328 ---LQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEAT- 383
+R + + R+ ++R ++ AS + P T + + T
Sbjct: 1881 PLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTP 1940
Query: 384 ------RSLLQAWERQRQEERQQAELR---RARTQHVQRQVAHCLAAYAPR---GSRGPG 431
RS R+R R R R+RT + R+ + + R SR
Sbjct: 1941 TTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSP 2000
Query: 432 AAQRKLEE-----LRRQERQRFAEYQAELQGIQHRVQAR-PFLFQQAMQANARLTVTRRF 485
+R+ RR+ R R I+ R ++R P L ++ ++ + L + RR
Sbjct: 2001 VTRRRSRSRTSPVTRRRSRSRTP------PAIRRRSRSRTPLLPRKRSRSRSPLAIRRR- 2053
Query: 486 SQVLSALGLDEEQLLSEAGKVDREGTPRKPRSHRSMGVRMEHSPQRPPRTEPTGSQPDR 544
R TPR R RS + SP R +GS DR
Sbjct: 2054 ---------------------SRSRTPRTARGKRS----LTRSPPAIRRRSASGSSSDR 2087
Score = 29.6 bits (65), Expect = 7.6
Identities = 61/273 (22%), Positives = 96/273 (35%), Gaps = 33/273 (12%)
Query: 64 QQRS--QSSRQTAKKDRKPRGQSKKGQGSEESEDHFPLLPRK-PSFPFQWAWESIATDVR 120
Q+RS +SS K R P S G + P PR+ PS S V+
Sbjct: 868 QRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTP--PRQSPSRS-----SSPQPKVK 920
Query: 121 AVLQPSSPTPGHQALPMPSSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWG- 179
A++ P + + P PS + R + R+S + P C E++ L G+
Sbjct: 921 AIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSP-----CSNVESRLLPRYSHSGSSSP 975
Query: 180 ----GVSIPTGKGELGS---------EPPSGLQLPGRRPGSGSASDKQVQLQSL-GAEEA 225
P + GS + P G L G + K +QS G+
Sbjct: 976 DTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSL 1035
Query: 226 ERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDE 285
G+ S P G S + + T + +P R++ + S + S +
Sbjct: 1036 CAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPK 1095
Query: 286 GEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGP 318
G G+S+ SSP R R+ R + P
Sbjct: 1096 G---GRSRSSSPVTELASRSPIRQDRGEFSASP 1125
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 42.7 bits (99), Expect = 9e-04
Identities = 101/480 (21%), Positives = 175/480 (36%), Gaps = 68/480 (14%)
Query: 65 QRSQSSRQTAKKDRKPRGQSKKGQGSEESEDHFPLLPRKPSFPFQWAWESIATDVRAVLQ 124
++ + R+ +++ K R + + Q EE H + F W W++ R +
Sbjct: 724 RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQR 783
Query: 125 PSSPTPGHQALPMPSSFSQRQSRRKSTANLPEAHGCCWK--------TEAQNLKARQQLG 176
S+ P + +RQ R + LPE + E Q L+ +QL
Sbjct: 784 LSARPPLREQRERQLRAEERQQREQRF--LPEEEEKEQRRRQRREREKELQFLEEEEQLQ 841
Query: 177 AWGGVSIPTGKGELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQ 236
+ + E GLQ R S Q L E ER L
Sbjct: 842 R-------RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL---EEERKRRRHTLYA 891
Query: 237 RPR-RGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGS 295
+P + + +E+Q + EE + E R RR+ +++ Q EE + E Q +
Sbjct: 892 KPALQEQLRKEQQLLQEEEEELQREEREKRRRQ---EQERQYREEEQLQQEEEQLLREER 948
Query: 296 SPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNG 355
R RQ+RK + KL ++ ++ L P+K R + K
Sbjct: 949 EKRRRQERERQYRKDK-----------KLQQKEEQLLGEEPEK-----RRRQEREKKYRE 992
Query: 356 KAYASGYDETFVSANLPNRTFHKRQEATRSLLQAWERQ--RQEERQQAELRRARTQHVQR 413
+ +E + R+E + Q WERQ +++E QQ E + R + +R
Sbjct: 993 EEELQQEEEQLL-----------REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041
Query: 414 QVAHCLAAYAPRGSRGPGAAQRKLEELRRQERQRFAEYQ--AELQGIQHRVQARPFLFQQ 471
++ Y R+ EEL+++E Q E + Q ++ + + L QQ
Sbjct: 1042 RLQERERQY------------REEEELQQEEEQLLGEERETRRRQELERQYRKEEEL-QQ 1088
Query: 472 AMQANARLTVTRRFSQVLSALGLDEEQLLSEAGKVDREGTPRKPRSHRSMGVRMEHSPQR 531
+ R +R Q +EE+L E ++ RE ++ R R E Q+
Sbjct: 1089 EEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQ 1148
Score = 41.2 bits (95), Expect = 0.003
Identities = 69/325 (21%), Positives = 126/325 (38%), Gaps = 28/325 (8%)
Query: 211 SDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEAT-EEAEEGEHRTPCRRRA 269
S+KQ +L+ + + L + R +EEEQ E EE RRR
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 270 --GCQRKGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQ 327
+RKG+ E + Q + + F ++WRK + L++ Q
Sbjct: 215 LLELRRKGR--------EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266
Query: 328 LQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEATRSLL 387
QR+L ++L + Q +R + L + +R+E
Sbjct: 267 RQRELQEEEEQLR----KLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322
Query: 388 QAWER-QRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEELRRQERQ 446
+ ER ++QEER++ +LRR + + ++Q+ R +R+ EE RR+++
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRR-----EQEEERREQQLRREQEEERREQQL 377
Query: 447 RFAEYQAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQVLSALGLDEEQLLSEAGKV 506
R + Q ++ Q R +Q ++ +L RR Q+ L EQ L +
Sbjct: 378 RREQQLRREQQLRREQQLRR---EQQLRREQQL---RREQQLRREQQLRREQQLRREQEE 431
Query: 507 DREGTPRKPRSHRSMGVRMEHSPQR 531
+R + + R ++ E +R
Sbjct: 432 ERH-EQKHEQERREQRLKREQEERR 455
Score = 38.9 bits (89), Expect = 0.013
Identities = 64/270 (23%), Positives = 109/270 (40%), Gaps = 24/270 (8%)
Query: 213 KQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQ 272
+Q Q + L E+ R G ++ R EEEQ + EE + + R Q
Sbjct: 1527 QQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQ 1586
Query: 273 RKGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRD- 331
+ + E E E Q + Q R R++R+ ++L + ++LHRQ +RD
Sbjct: 1587 KVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRED--EQLLQEREEQQLHRQ-ERDR 1643
Query: 332 --LDCGPQ---KLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFH------KRQ 380
L+ PQ + + LR R + +E + +R F +RQ
Sbjct: 1644 KFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ 1703
Query: 381 EATRSLLQAWERQRQEE-----RQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQR 435
E R LQ ++ R++E R++ +LR+ Q R+ R +R
Sbjct: 1704 ERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLR----PER 1759
Query: 436 KLEELRRQERQRFAEYQAELQGIQHRVQAR 465
+ ++LRRQER R + +L+ + Q R
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLR 1789
Score = 38.1 bits (87), Expect = 0.021
Identities = 83/344 (24%), Positives = 131/344 (38%), Gaps = 52/344 (15%)
Query: 214 QVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQR 273
Q LQ L E+ ER ++ RR + F E E+ E E + RR Q
Sbjct: 1264 QQDLQHLLGEQQERDR------EQERRRWQQRDRHFPEE-EQLEREEQKEAKRRDRKSQE 1316
Query: 274 KGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQ------ 327
+ Q+ EE ++ Q + L+ R+ + R +E + E+L Q
Sbjct: 1317 EKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKF 1376
Query: 328 LQRDLDCGPQKLPWKTLRAAFQA-------SKRNGKAYASGYDETFVSANLPNRTFH--- 377
L+ + Q+ K L+ Q R + +E +S +R F
Sbjct: 1377 LEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEE 1436
Query: 378 ---KRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQ 434
+RQE R L+ ++ RQE ++ Q + Q H R R +
Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH-------RQERDRKFLE 1489
Query: 435 RKLEELRRQERQR-FAEYQAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQVLSALG 493
+ ++LRRQER R F E Q ++ + R FL ++ Q R R+F Q
Sbjct: 1490 EE-QQLRRQERDRKFRE-----QELRSQEPERKFLEEE--QQLHRQQRQRKFLQ------ 1535
Query: 494 LDEEQL-LSEAGKVDREGTPRKPRSHRSMGVRMEHSPQRPPRTE 536
+E+QL E G+ R+ RK R + R E Q+ R E
Sbjct: 1536 -EEQQLRRQERGQQRRQDRDRKFREEEQL--RQEREEQQLSRQE 1576
Score = 34.7 bits (78), Expect = 0.24
Identities = 58/256 (22%), Positives = 98/256 (38%), Gaps = 30/256 (11%)
Query: 220 LGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCR---RRAGCQRKGQ 276
L EE ER Q+ RR EQ + EE E + R RR +R+ Q
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 277 ISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLDCGP 336
+ E E + + Q RR Q K + Q ++L R+ + L+
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEE-RRDQLLKREEERRQ-----QRLKREQEERLE--- 599
Query: 337 QKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEATRSLLQAWERQRQE 396
Q+L + + Q +R + +E +RQ+ +S Q RQ+Q
Sbjct: 600 QRLKREEVERLEQEERREQRLKREEPEE------------ERRQQLLKSEEQEERRQQQL 647
Query: 397 ERQQAELR--RARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEELRRQERQRFAEYQ-- 452
R+Q E R R + + + ++ L R A+ + E+ R + + R ++Q
Sbjct: 648 RREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQ 707
Query: 453 --AELQGIQHRVQARP 466
+E Q +V +RP
Sbjct: 708 LESEADARQSKVYSRP 723
Score = 34.3 bits (77), Expect = 0.31
Identities = 49/199 (24%), Positives = 76/199 (38%), Gaps = 35/199 (17%)
Query: 374 RTFHKRQEATRSLLQAWER--------QRQEERQQAELRRARTQHVQR--------QVAH 417
R KRQE R L + E+ QR +R+ EL R R + +R Q+
Sbjct: 136 RRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQS 195
Query: 418 CLAAYAPRGSRGPGAAQRKLEELRRQERQRFAEYQAELQGIQHRVQARPFLFQQAMQANA 477
C +R+L ELRR+ R+ E Q + Q R F ++ +
Sbjct: 196 CKGHETEEFPDEEQLRRRELLELRRKGRE-------EKQQQRRERQDRVFQEEEEKEWRK 248
Query: 478 RLTVTRRFSQVLS--------ALGLDEEQL----LSEAGKVDREGTPRKPRSHRSMGVRM 525
R TV R+ + L L +EEQL E + +E ++ R R +R
Sbjct: 249 RETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRR 308
Query: 526 EHSPQRPPRTEPTGSQPDR 544
+ +R + E Q +R
Sbjct: 309 KQEEERREQQEERREQQER 327
Score = 34.3 bits (77), Expect = 0.31
Identities = 61/326 (18%), Positives = 124/326 (38%), Gaps = 35/326 (10%)
Query: 223 EEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEA 282
+E ER ++ R EE + + E EE + R + +R+ Q+ E+
Sbjct: 310 QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQE 369
Query: 283 SDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLDCGPQKLPWK 342
+ E Q + + LRR Q + R ++L+ L + +QL+R+ ++
Sbjct: 370 EERREQQLRREQQLRREQQLRREQQLR-REQQLRREQQLRR-EQQLRREQQLRREQ---- 423
Query: 343 TLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEATRS----------------- 385
LR + + K ++ R + KR+E T
Sbjct: 424 QLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEE 483
Query: 386 ------LLQAWERQRQEERQQAELRR----ARTQHVQRQVAHCLAAYAPRGSRGPGAAQR 435
L+ ER+ Q+ER++ +LRR R Q ++RQ R + Q
Sbjct: 484 RRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQE 543
Query: 436 KLEE--LRRQERQRFAEYQAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQVLSALG 493
+ E L+R+E +R + + E + + + + R L ++ + + + ++ L
Sbjct: 544 ERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK 603
Query: 494 LDEEQLLSEAGKVDREGTPRKPRSHR 519
+E + L + + ++ +P R
Sbjct: 604 REEVERLEQEERREQRLKREEPEEER 629
Score = 34.3 bits (77), Expect = 0.31
Identities = 43/199 (21%), Positives = 79/199 (39%), Gaps = 26/199 (13%)
Query: 218 QSLGAEEAERGL-SSGVLPQRPRRGSISEEEQFSEATEEAE-EGEHRTPCRRRAGCQRKG 275
Q L +E ER L Q + + +E++ + EE + E RR RK
Sbjct: 1714 QQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKF 1773
Query: 276 QISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLDCG 335
+ + + E Q +SQ S F Q R+ R ++ P + +R + L
Sbjct: 1774 REEEQLRQEREEQQLRSQESDRKFRE--EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLE 1831
Query: 336 PQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEATRSLLQAWERQRQ 395
Q+ + LR R + +A+ ++++ R + W+ + Q
Sbjct: 1832 EQE---QRLRQERDRQYRAEEQFAT------------------QEKSRREEQELWQEEEQ 1870
Query: 396 EERQQAELRRARTQHVQRQ 414
+ RQ+ E R+ R +H++RQ
Sbjct: 1871 KRRQERE-RKLREEHIRRQ 1888
Score = 33.9 bits (76), Expect = 0.40
Identities = 72/338 (21%), Positives = 127/338 (37%), Gaps = 27/338 (7%)
Query: 214 QVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQR 273
Q QL+S + S + RR EE++ +E + E R +++ QR
Sbjct: 705 QWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQR 764
Query: 274 KGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQG---PWDLEKLHRQLQR 330
+ +A ++ E Q + P R RQ R ++ + P + EK R+ QR
Sbjct: 765 RDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQR 824
Query: 331 DLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEATRSLLQAW 390
++ + L Q +R +A +E + + R + QE R Q W
Sbjct: 825 ----REREKELQFLEEEEQLQRRE-RAQQLQEEEDGLQEDQERR---RSQEQRRD--QKW 874
Query: 391 ERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEELRRQERQ--RF 448
Q +EER++ +R + A + + Q + EEL+R+ER+ R
Sbjct: 875 RWQLEEERKR-----------RRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRR 923
Query: 449 AEYQAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQVLSALGLDEEQLLSEAGKVDR 508
E + + + + Q L ++ + R R++ + L EEQLL E + R
Sbjct: 924 QEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD-KKLQQKEEQLLGEEPEKRR 982
Query: 509 EGTPRKPRSHRSMGVRMEHSPQRPPRTEPTGSQPDRHY 546
K + E R R + + +R Y
Sbjct: 983 RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQY 1020
Score = 32.7 bits (73), Expect = 0.90
Identities = 39/195 (20%), Positives = 70/195 (35%), Gaps = 29/195 (14%)
Query: 378 KRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAY--------------- 422
KR+E L Q +R+ +EER++ EL + + ++ + +
Sbjct: 660 KREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKV 719
Query: 423 --APRGSRGPGAAQRKLEELRRQERQ-RFAEYQAELQGIQHRVQARPFLFQ--------- 470
PR G Q + E+ RR+E + ++ E + + Q Q R F +Q
Sbjct: 720 YSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSER 779
Query: 471 --QAMQANARLTVTRRFSQVLSALGLDEEQLLSEAGKVDREGTPRKPRSHRSMGVRMEHS 528
Q + A L R E++ L E + ++ R+ R + E
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839
Query: 529 PQRPPRTEPTGSQPD 543
QR R + + D
Sbjct: 840 LQRRERAQQLQEEED 854
Score = 32.7 bits (73), Expect = 0.90
Identities = 57/262 (21%), Positives = 104/262 (39%), Gaps = 31/262 (11%)
Query: 199 QLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEE 258
QL G P +++ + + EE ++ + +R +R E Q+ + E +E
Sbjct: 972 QLLGEEPEKRRRQEREKKYRE--EEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE 1029
Query: 259 GEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGP 318
E R +R+ Q + +E E+Q + + RRRQ
Sbjct: 1030 EEQLLREERE---KRRLQERERQYREEEELQQEEEQLLGEERETRRRQ------------ 1074
Query: 319 WDLEKLHR---QLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRT 375
+LE+ +R +LQ++ + ++ P K R + R + ++ R
Sbjct: 1075 -ELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE----ERE 1129
Query: 376 FHKRQEATRSLLQAWERQRQEERQ-QAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQ 434
+RQE R + E Q++EE+ + E + R Q ++RQ +
Sbjct: 1130 KRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYRE-----EEELQQEEEQLL 1184
Query: 435 RKLEELRRQERQRFAEYQAELQ 456
R+ +E RRQER+R + ELQ
Sbjct: 1185 REEQEKRRQERERQYREEEELQ 1206
Score = 31.6 bits (70), Expect = 2.0
Identities = 47/212 (22%), Positives = 84/212 (39%), Gaps = 36/212 (16%)
Query: 236 QRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGS 295
+R +R E Q+ E E +E E R R+ Q + E E+Q + +
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERET---RRRQELERQYRKEEELQQEEEQL 1093
Query: 296 SPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNG 355
RRRQ R+ + +E + +L++ QL R+ + R + ++
Sbjct: 1094 LREEPEKRRRQERERQCREEE---ELQQEEEQLLREE---------REKRRRQELERQYR 1141
Query: 356 KAYASGYDETFVSANLPNRTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQV 415
+ +E + P + +RQE R + E Q++EE+ E + R Q +RQ
Sbjct: 1142 EEEEVQQEEEQLLREEPEK--RRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQ- 1198
Query: 416 AHCLAAYAPRGSRGPGAAQRKLEELRRQERQR 447
R+ EEL+RQ+R++
Sbjct: 1199 ------------------YREEEELQRQKRKQ 1212
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 41.6 bits (96), Expect = 0.002
Identities = 46/183 (25%), Positives = 75/183 (40%), Gaps = 23/183 (12%)
Query: 374 RTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAA 433
+ +++E R L + R+R+ RQQ +R R Q +R++ R +
Sbjct: 397 KRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEE-----LERRRKEEEER 451
Query: 434 QRKLEELRRQER-QRFAEYQAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQVLSAL 492
+R EE RR ER Q + Q E + V + L +QAM R R + A
Sbjct: 452 RRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECR---WREMEEHRQAE 508
Query: 493 GLDEEQLLSEAGKVDREGTPRKPRSHRSMGVRMEHSPQRPP----RTEPT--GSQPDRHY 546
L + +A + + R+P +HS Q PP R++P+ +P HY
Sbjct: 509 RLQRQLQQEQAYLLSLQHDHRRPHP--------QHSQQPPPPQQERSKPSFHAPEPKAHY 560
Query: 547 NPS 549
P+
Sbjct: 561 EPA 563
>gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo
sapiens]
Length = 434
Score = 41.6 bits (96), Expect = 0.002
Identities = 41/211 (19%), Positives = 83/211 (39%), Gaps = 13/211 (6%)
Query: 280 EEASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLDCGPQKL 339
++ ++ EV + S ++ R R + R + +G + HR R + +
Sbjct: 21 DKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEG-----RKHRSRSRSKEGRRHES 75
Query: 340 PWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEATRSLLQAWERQRQEERQ 399
K+ + ++ + N K ++S ++++ HKR+E S ++ R R ER+
Sbjct: 76 KDKSSKK-HKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERR 134
Query: 400 QAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEELRRQERQRFAEYQAELQGIQ 459
R R + R + SR ++K R+ ++R +
Sbjct: 135 HRSRSRERKKSRSRSRER-------KKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHR 187
Query: 460 HRVQARPFLFQQAMQANARLTVTRRFSQVLS 490
HR ++R ++ R+ RRFS+ LS
Sbjct: 188 HRTRSRSRTRSRSRDRKKRIEKPRRFSRSLS 218
Score = 29.3 bits (64), Expect = 9.9
Identities = 33/170 (19%), Positives = 66/170 (38%), Gaps = 23/170 (13%)
Query: 237 RPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSS 296
R S S E + + E ++ R+ R+++ + + + S E + + +S+ S
Sbjct: 123 RSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRS 182
Query: 297 PSFNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGK 356
S + R R +TR++ +EK R+ R L P P++ A A +
Sbjct: 183 RSRHRHRTRSRSRTRSRSRDRKKRIEK-PRRFSRSLSRTPSPPPFRGRNTAMDAQE---- 237
Query: 357 AYASGYDETFVSANLPNRTFHKRQEATRSLLQAWERQRQEERQQAELRRA 406
+R E + L + E++ E+++Q E+ A
Sbjct: 238 ------------------ALARRLERAKKLQEQREKEMVEKQKQQEIAAA 269
>gi|7705415 hook homolog 1 [Homo sapiens]
Length = 728
Score = 39.3 bits (90), Expect = 0.010
Identities = 35/175 (20%), Positives = 72/175 (41%), Gaps = 10/175 (5%)
Query: 362 YDETFVSANLPNRTFHKRQEATRS--------LLQAWERQRQEERQQAELRRARTQHVQR 413
Y E F+ N+ +QE + + L+ R+ E + L + R + +Q+
Sbjct: 463 YREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQ 522
Query: 414 QVAHCLAAYAPRGSRGPGAAQRKLEELRRQERQRFAEYQAELQGIQHRVQ-ARPFLFQQA 472
Q+ + +GS+ G + KL++ ++ E ELQ Q ++ +P + Q
Sbjct: 523 QIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNV 582
Query: 473 MQANARLTVTRRFSQVLSALGLDEEQLLSEAGKVDREGTPR-KPRSHRSMGVRME 526
+ N ++ + + A+ + L +A V + P+ P S M +R +
Sbjct: 583 QKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQ 637
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 39.3 bits (90), Expect = 0.010
Identities = 84/362 (23%), Positives = 137/362 (37%), Gaps = 58/362 (16%)
Query: 133 QALPMPSSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELGS 192
QA+P+ S + R+ R+ A L E K E A+Q + A + +
Sbjct: 1234 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1293
Query: 193 EP-PSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSE 251
EP S + P + GS S + V L++ +E L+S + EEE+
Sbjct: 1294 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT--LTSQYIKFISETLRRMEEEERLA 1351
Query: 252 ATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTR 311
+ AEE E A +++ Q++ E Q ++Q +
Sbjct: 1352 EQQRAEERERLAEV--EAALEKQRQLA------EAHAQAKAQA--------------ERE 1389
Query: 312 AKELQGPWDLEKLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANL 371
AKELQ E + R+ + +D QK ++++ Q +++ +A +A
Sbjct: 1390 AKELQQRMQEEVVRRE-EAAVDAQQQK---RSIQEELQQLRQSSEAEIQAKARQAEAAER 1445
Query: 372 PNRTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPG 431
+ R L+A ERQR + + RAR + + Q
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ-------------- 1491
Query: 432 AAQRKLEELRRQ-----ERQRFAEYQ------AELQGI---QHRVQARPFLFQQAMQANA 477
AQ + E LRRQ +R+R AE + AE + Q +QA L QA +A
Sbjct: 1492 -AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1550
Query: 478 RL 479
RL
Sbjct: 1551 RL 1552
Score = 35.4 bits (80), Expect = 0.14
Identities = 83/329 (25%), Positives = 123/329 (37%), Gaps = 56/329 (17%)
Query: 215 VQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRK 274
V+LQ L A E +RG + G L Q R + E Q +A EEAE + + QRK
Sbjct: 1457 VRLQ-LEATERQRGGAEGEL-QALRARAEEAEAQKRQAQEEAERLRRQV----QDESQRK 1510
Query: 275 GQISGEEASD---EGEVQGQSQGSSPSFNNLRR---------RQWRKTRAKELQGPWDLE 322
Q E AS E E + Q + + LR RQ RA+++Q LE
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA--LE 1568
Query: 323 KLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEA 382
R + +L KT + ++ + A A +E A R+EA
Sbjct: 1569 TAQRSAEAELQSKRASFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627
Query: 383 TRSL--------------LQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSR 428
R L LQA E +Q+ QAE + + + A R +R
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE-------------AEREAR 1674
Query: 429 GPGAA------QRKLEELRRQERQRFAE--YQAELQGIQHRVQARPFLFQQAMQANARLT 480
G A QR+L E +++++ AE Q L Q ++ R Q Q
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1734
Query: 481 VTRRFSQVLSALGLDEEQLLSEAGKVDRE 509
R + +A ++L +E KV E
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAE 1763
Score = 33.5 bits (75), Expect = 0.53
Identities = 61/300 (20%), Positives = 110/300 (36%), Gaps = 26/300 (8%)
Query: 214 QVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQR 273
+ + A +AE L G + S+E+ EA + + RR A +
Sbjct: 1931 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1990
Query: 274 KGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLD 333
+ ++ EE E Q + + L+ + R +E ++ RQLQ +
Sbjct: 1991 QKSLAAEE-----EAARQRKAALEEVERLKAKVEEARRLRERAE----QESARQLQLAQE 2041
Query: 334 CGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKR---QEATRSLLQAW 390
++L + AF ++ + + E V L R +EA + +QA
Sbjct: 2042 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA- 2100
Query: 391 ERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEELRRQERQRFA- 449
ER+ + R+Q E Q + Q ++ AQ E+LR++ Q A
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQ------------AQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 450 EYQAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQVLSALGLDEEQLLSEAGKVDRE 509
QAE ++ + A + + A L + Q L+ L L E+ + +D E
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Score = 29.6 bits (65), Expect = 7.6
Identities = 30/83 (36%), Positives = 39/83 (46%), Gaps = 13/83 (15%)
Query: 380 QEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEE 439
QEATR +A Q+Q+E Q + R R Q + Q+A LA QR LE
Sbjct: 2320 QEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQ-------GFQRTLE- 2369
Query: 440 LRRQERQRFAEYQAELQGIQHRV 462
ERQR E AE + ++ RV
Sbjct: 2370 ---AERQRQLEMSAEAERLKLRV 2389
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 39.3 bits (90), Expect = 0.010
Identities = 84/362 (23%), Positives = 137/362 (37%), Gaps = 58/362 (16%)
Query: 133 QALPMPSSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELGS 192
QA+P+ S + R+ R+ A L E K E A+Q + A + +
Sbjct: 1238 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1297
Query: 193 EP-PSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSE 251
EP S + P + GS S + V L++ +E L+S + EEE+
Sbjct: 1298 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT--LTSQYIKFISETLRRMEEEERLA 1355
Query: 252 ATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTR 311
+ AEE E A +++ Q++ E Q ++Q +
Sbjct: 1356 EQQRAEERERLAEV--EAALEKQRQLA------EAHAQAKAQA--------------ERE 1393
Query: 312 AKELQGPWDLEKLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANL 371
AKELQ E + R+ + +D QK ++++ Q +++ +A +A
Sbjct: 1394 AKELQQRMQEEVVRRE-EAAVDAQQQK---RSIQEELQQLRQSSEAEIQAKARQAEAAER 1449
Query: 372 PNRTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPG 431
+ R L+A ERQR + + RAR + + Q
Sbjct: 1450 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ-------------- 1495
Query: 432 AAQRKLEELRRQ-----ERQRFAEYQ------AELQGI---QHRVQARPFLFQQAMQANA 477
AQ + E LRRQ +R+R AE + AE + Q +QA L QA +A
Sbjct: 1496 -AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1554
Query: 478 RL 479
RL
Sbjct: 1555 RL 1556
Score = 35.4 bits (80), Expect = 0.14
Identities = 83/329 (25%), Positives = 123/329 (37%), Gaps = 56/329 (17%)
Query: 215 VQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRK 274
V+LQ L A E +RG + G L Q R + E Q +A EEAE + + QRK
Sbjct: 1461 VRLQ-LEATERQRGGAEGEL-QALRARAEEAEAQKRQAQEEAERLRRQV----QDESQRK 1514
Query: 275 GQISGEEASD---EGEVQGQSQGSSPSFNNLRR---------RQWRKTRAKELQGPWDLE 322
Q E AS E E + Q + + LR RQ RA+++Q LE
Sbjct: 1515 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA--LE 1572
Query: 323 KLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEA 382
R + +L KT + ++ + A A +E A R+EA
Sbjct: 1573 TAQRSAEAELQSKRASFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1631
Query: 383 TRSL--------------LQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSR 428
R L LQA E +Q+ QAE + + + A R +R
Sbjct: 1632 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE-------------AEREAR 1678
Query: 429 GPGAA------QRKLEELRRQERQRFAE--YQAELQGIQHRVQARPFLFQQAMQANARLT 480
G A QR+L E +++++ AE Q L Q ++ R Q Q
Sbjct: 1679 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1738
Query: 481 VTRRFSQVLSALGLDEEQLLSEAGKVDRE 509
R + +A ++L +E KV E
Sbjct: 1739 ELARLQREAAAATQKRQELEAELAKVRAE 1767
Score = 33.5 bits (75), Expect = 0.53
Identities = 61/300 (20%), Positives = 110/300 (36%), Gaps = 26/300 (8%)
Query: 214 QVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQR 273
+ + A +AE L G + S+E+ EA + + RR A +
Sbjct: 1935 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1994
Query: 274 KGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLD 333
+ ++ EE E Q + + L+ + R +E ++ RQLQ +
Sbjct: 1995 QKSLAAEE-----EAARQRKAALEEVERLKAKVEEARRLRERAE----QESARQLQLAQE 2045
Query: 334 CGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKR---QEATRSLLQAW 390
++L + AF ++ + + E V L R +EA + +QA
Sbjct: 2046 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA- 2104
Query: 391 ERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEELRRQERQRFA- 449
ER+ + R+Q E Q + Q ++ AQ E+LR++ Q A
Sbjct: 2105 EREAAQSRRQVEEAERLKQSAEEQ------------AQARAQAQAAAEKLRKEAEQEAAR 2152
Query: 450 EYQAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQVLSALGLDEEQLLSEAGKVDRE 509
QAE ++ + A + + A L + Q L+ L L E+ + +D E
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2212
Score = 29.6 bits (65), Expect = 7.6
Identities = 30/83 (36%), Positives = 39/83 (46%), Gaps = 13/83 (15%)
Query: 380 QEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEE 439
QEATR +A Q+Q+E Q + R R Q + Q+A LA QR LE
Sbjct: 2324 QEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQ-------GFQRTLE- 2373
Query: 440 LRRQERQRFAEYQAELQGIQHRV 462
ERQR E AE + ++ RV
Sbjct: 2374 ---AERQRQLEMSAEAERLKLRV 2393
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 39.3 bits (90), Expect = 0.010
Identities = 84/362 (23%), Positives = 137/362 (37%), Gaps = 58/362 (16%)
Query: 133 QALPMPSSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELGS 192
QA+P+ S + R+ R+ A L E K E A+Q + A + +
Sbjct: 1234 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1293
Query: 193 EP-PSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSE 251
EP S + P + GS S + V L++ +E L+S + EEE+
Sbjct: 1294 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT--LTSQYIKFISETLRRMEEEERLA 1351
Query: 252 ATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTR 311
+ AEE E A +++ Q++ E Q ++Q +
Sbjct: 1352 EQQRAEERERLAEV--EAALEKQRQLA------EAHAQAKAQA--------------ERE 1389
Query: 312 AKELQGPWDLEKLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANL 371
AKELQ E + R+ + +D QK ++++ Q +++ +A +A
Sbjct: 1390 AKELQQRMQEEVVRRE-EAAVDAQQQK---RSIQEELQQLRQSSEAEIQAKARQAEAAER 1445
Query: 372 PNRTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPG 431
+ R L+A ERQR + + RAR + + Q
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ-------------- 1491
Query: 432 AAQRKLEELRRQ-----ERQRFAEYQ------AELQGI---QHRVQARPFLFQQAMQANA 477
AQ + E LRRQ +R+R AE + AE + Q +QA L QA +A
Sbjct: 1492 -AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1550
Query: 478 RL 479
RL
Sbjct: 1551 RL 1552
Score = 35.4 bits (80), Expect = 0.14
Identities = 83/329 (25%), Positives = 123/329 (37%), Gaps = 56/329 (17%)
Query: 215 VQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRK 274
V+LQ L A E +RG + G L Q R + E Q +A EEAE + + QRK
Sbjct: 1457 VRLQ-LEATERQRGGAEGEL-QALRARAEEAEAQKRQAQEEAERLRRQV----QDESQRK 1510
Query: 275 GQISGEEASD---EGEVQGQSQGSSPSFNNLRR---------RQWRKTRAKELQGPWDLE 322
Q E AS E E + Q + + LR RQ RA+++Q LE
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA--LE 1568
Query: 323 KLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEA 382
R + +L KT + ++ + A A +E A R+EA
Sbjct: 1569 TAQRSAEAELQSKRASFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627
Query: 383 TRSL--------------LQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSR 428
R L LQA E +Q+ QAE + + + A R +R
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE-------------AEREAR 1674
Query: 429 GPGAA------QRKLEELRRQERQRFAE--YQAELQGIQHRVQARPFLFQQAMQANARLT 480
G A QR+L E +++++ AE Q L Q ++ R Q Q
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1734
Query: 481 VTRRFSQVLSALGLDEEQLLSEAGKVDRE 509
R + +A ++L +E KV E
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAE 1763
Score = 33.5 bits (75), Expect = 0.53
Identities = 61/300 (20%), Positives = 110/300 (36%), Gaps = 26/300 (8%)
Query: 214 QVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQR 273
+ + A +AE L G + S+E+ EA + + RR A +
Sbjct: 1931 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1990
Query: 274 KGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLD 333
+ ++ EE E Q + + L+ + R +E ++ RQLQ +
Sbjct: 1991 QKSLAAEE-----EAARQRKAALEEVERLKAKVEEARRLRERAE----QESARQLQLAQE 2041
Query: 334 CGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKR---QEATRSLLQAW 390
++L + AF ++ + + E V L R +EA + +QA
Sbjct: 2042 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA- 2100
Query: 391 ERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEELRRQERQRFA- 449
ER+ + R+Q E Q + Q ++ AQ E+LR++ Q A
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQ------------AQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 450 EYQAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQVLSALGLDEEQLLSEAGKVDRE 509
QAE ++ + A + + A L + Q L+ L L E+ + +D E
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2208
Score = 29.6 bits (65), Expect = 7.6
Identities = 30/83 (36%), Positives = 39/83 (46%), Gaps = 13/83 (15%)
Query: 380 QEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEE 439
QEATR +A Q+Q+E Q + R R Q + Q+A LA QR LE
Sbjct: 2320 QEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQ-------GFQRTLE- 2369
Query: 440 LRRQERQRFAEYQAELQGIQHRV 462
ERQR E AE + ++ RV
Sbjct: 2370 ---AERQRQLEMSAEAERLKLRV 2389
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 39.3 bits (90), Expect = 0.010
Identities = 84/362 (23%), Positives = 137/362 (37%), Gaps = 58/362 (16%)
Query: 133 QALPMPSSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELGS 192
QA+P+ S + R+ R+ A L E K E A+Q + A + +
Sbjct: 1202 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1261
Query: 193 EP-PSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSE 251
EP S + P + GS S + V L++ +E L+S + EEE+
Sbjct: 1262 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT--LTSQYIKFISETLRRMEEEERLA 1319
Query: 252 ATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTR 311
+ AEE E A +++ Q++ E Q ++Q +
Sbjct: 1320 EQQRAEERERLAEV--EAALEKQRQLA------EAHAQAKAQA--------------ERE 1357
Query: 312 AKELQGPWDLEKLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANL 371
AKELQ E + R+ + +D QK ++++ Q +++ +A +A
Sbjct: 1358 AKELQQRMQEEVVRRE-EAAVDAQQQK---RSIQEELQQLRQSSEAEIQAKARQAEAAER 1413
Query: 372 PNRTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPG 431
+ R L+A ERQR + + RAR + + Q
Sbjct: 1414 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ-------------- 1459
Query: 432 AAQRKLEELRRQ-----ERQRFAEYQ------AELQGI---QHRVQARPFLFQQAMQANA 477
AQ + E LRRQ +R+R AE + AE + Q +QA L QA +A
Sbjct: 1460 -AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1518
Query: 478 RL 479
RL
Sbjct: 1519 RL 1520
Score = 35.4 bits (80), Expect = 0.14
Identities = 83/329 (25%), Positives = 123/329 (37%), Gaps = 56/329 (17%)
Query: 215 VQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRK 274
V+LQ L A E +RG + G L Q R + E Q +A EEAE + + QRK
Sbjct: 1425 VRLQ-LEATERQRGGAEGEL-QALRARAEEAEAQKRQAQEEAERLRRQV----QDESQRK 1478
Query: 275 GQISGEEASD---EGEVQGQSQGSSPSFNNLRR---------RQWRKTRAKELQGPWDLE 322
Q E AS E E + Q + + LR RQ RA+++Q LE
Sbjct: 1479 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA--LE 1536
Query: 323 KLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEA 382
R + +L KT + ++ + A A +E A R+EA
Sbjct: 1537 TAQRSAEAELQSKRASFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1595
Query: 383 TRSL--------------LQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSR 428
R L LQA E +Q+ QAE + + + A R +R
Sbjct: 1596 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE-------------AEREAR 1642
Query: 429 GPGAA------QRKLEELRRQERQRFAE--YQAELQGIQHRVQARPFLFQQAMQANARLT 480
G A QR+L E +++++ AE Q L Q ++ R Q Q
Sbjct: 1643 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1702
Query: 481 VTRRFSQVLSALGLDEEQLLSEAGKVDRE 509
R + +A ++L +E KV E
Sbjct: 1703 ELARLQREAAAATQKRQELEAELAKVRAE 1731
Score = 33.5 bits (75), Expect = 0.53
Identities = 61/300 (20%), Positives = 110/300 (36%), Gaps = 26/300 (8%)
Query: 214 QVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQR 273
+ + A +AE L G + S+E+ EA + + RR A +
Sbjct: 1899 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1958
Query: 274 KGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLD 333
+ ++ EE E Q + + L+ + R +E ++ RQLQ +
Sbjct: 1959 QKSLAAEE-----EAARQRKAALEEVERLKAKVEEARRLRERAE----QESARQLQLAQE 2009
Query: 334 CGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKR---QEATRSLLQAW 390
++L + AF ++ + + E V L R +EA + +QA
Sbjct: 2010 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA- 2068
Query: 391 ERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEELRRQERQRFA- 449
ER+ + R+Q E Q + Q ++ AQ E+LR++ Q A
Sbjct: 2069 EREAAQSRRQVEEAERLKQSAEEQ------------AQARAQAQAAAEKLRKEAEQEAAR 2116
Query: 450 EYQAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQVLSALGLDEEQLLSEAGKVDRE 509
QAE ++ + A + + A L + Q L+ L L E+ + +D E
Sbjct: 2117 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2176
Score = 29.6 bits (65), Expect = 7.6
Identities = 30/83 (36%), Positives = 39/83 (46%), Gaps = 13/83 (15%)
Query: 380 QEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEE 439
QEATR +A Q+Q+E Q + R R Q + Q+A LA QR LE
Sbjct: 2288 QEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQ-------GFQRTLE- 2337
Query: 440 LRRQERQRFAEYQAELQGIQHRV 462
ERQR E AE + ++ RV
Sbjct: 2338 ---AERQRQLEMSAEAERLKLRV 2357
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 39.3 bits (90), Expect = 0.010
Identities = 84/362 (23%), Positives = 137/362 (37%), Gaps = 58/362 (16%)
Query: 133 QALPMPSSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELGS 192
QA+P+ S + R+ R+ A L E K E A+Q + A + +
Sbjct: 1371 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1430
Query: 193 EP-PSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSE 251
EP S + P + GS S + V L++ +E L+S + EEE+
Sbjct: 1431 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT--LTSQYIKFISETLRRMEEEERLA 1488
Query: 252 ATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTR 311
+ AEE E A +++ Q++ E Q ++Q +
Sbjct: 1489 EQQRAEERERLAEV--EAALEKQRQLA------EAHAQAKAQA--------------ERE 1526
Query: 312 AKELQGPWDLEKLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANL 371
AKELQ E + R+ + +D QK ++++ Q +++ +A +A
Sbjct: 1527 AKELQQRMQEEVVRRE-EAAVDAQQQK---RSIQEELQQLRQSSEAEIQAKARQAEAAER 1582
Query: 372 PNRTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPG 431
+ R L+A ERQR + + RAR + + Q
Sbjct: 1583 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ-------------- 1628
Query: 432 AAQRKLEELRRQ-----ERQRFAEYQ------AELQGI---QHRVQARPFLFQQAMQANA 477
AQ + E LRRQ +R+R AE + AE + Q +QA L QA +A
Sbjct: 1629 -AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1687
Query: 478 RL 479
RL
Sbjct: 1688 RL 1689
Score = 35.4 bits (80), Expect = 0.14
Identities = 83/329 (25%), Positives = 123/329 (37%), Gaps = 56/329 (17%)
Query: 215 VQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRK 274
V+LQ L A E +RG + G L Q R + E Q +A EEAE + + QRK
Sbjct: 1594 VRLQ-LEATERQRGGAEGEL-QALRARAEEAEAQKRQAQEEAERLRRQV----QDESQRK 1647
Query: 275 GQISGEEASD---EGEVQGQSQGSSPSFNNLRR---------RQWRKTRAKELQGPWDLE 322
Q E AS E E + Q + + LR RQ RA+++Q LE
Sbjct: 1648 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA--LE 1705
Query: 323 KLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEA 382
R + +L KT + ++ + A A +E A R+EA
Sbjct: 1706 TAQRSAEAELQSKRASFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1764
Query: 383 TRSL--------------LQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSR 428
R L LQA E +Q+ QAE + + + A R +R
Sbjct: 1765 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE-------------AEREAR 1811
Query: 429 GPGAA------QRKLEELRRQERQRFAE--YQAELQGIQHRVQARPFLFQQAMQANARLT 480
G A QR+L E +++++ AE Q L Q ++ R Q Q
Sbjct: 1812 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1871
Query: 481 VTRRFSQVLSALGLDEEQLLSEAGKVDRE 509
R + +A ++L +E KV E
Sbjct: 1872 ELARLQREAAAATQKRQELEAELAKVRAE 1900
Score = 33.5 bits (75), Expect = 0.53
Identities = 61/300 (20%), Positives = 110/300 (36%), Gaps = 26/300 (8%)
Query: 214 QVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQR 273
+ + A +AE L G + S+E+ EA + + RR A +
Sbjct: 2068 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 2127
Query: 274 KGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLD 333
+ ++ EE E Q + + L+ + R +E ++ RQLQ +
Sbjct: 2128 QKSLAAEE-----EAARQRKAALEEVERLKAKVEEARRLRERAE----QESARQLQLAQE 2178
Query: 334 CGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKR---QEATRSLLQAW 390
++L + AF ++ + + E V L R +EA + +QA
Sbjct: 2179 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA- 2237
Query: 391 ERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEELRRQERQRFA- 449
ER+ + R+Q E Q + Q ++ AQ E+LR++ Q A
Sbjct: 2238 EREAAQSRRQVEEAERLKQSAEEQ------------AQARAQAQAAAEKLRKEAEQEAAR 2285
Query: 450 EYQAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQVLSALGLDEEQLLSEAGKVDRE 509
QAE ++ + A + + A L + Q L+ L L E+ + +D E
Sbjct: 2286 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2345
Score = 29.6 bits (65), Expect = 7.6
Identities = 30/83 (36%), Positives = 39/83 (46%), Gaps = 13/83 (15%)
Query: 380 QEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEE 439
QEATR +A Q+Q+E Q + R R Q + Q+A LA QR LE
Sbjct: 2457 QEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQ-------GFQRTLE- 2506
Query: 440 LRRQERQRFAEYQAELQGIQHRV 462
ERQR E AE + ++ RV
Sbjct: 2507 ---AERQRQLEMSAEAERLKLRV 2526
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 39.3 bits (90), Expect = 0.010
Identities = 84/362 (23%), Positives = 137/362 (37%), Gaps = 58/362 (16%)
Query: 133 QALPMPSSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELGS 192
QA+P+ S + R+ R+ A L E K E A+Q + A + +
Sbjct: 1212 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1271
Query: 193 EP-PSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSE 251
EP S + P + GS S + V L++ +E L+S + EEE+
Sbjct: 1272 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT--LTSQYIKFISETLRRMEEEERLA 1329
Query: 252 ATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTR 311
+ AEE E A +++ Q++ E Q ++Q +
Sbjct: 1330 EQQRAEERERLAEV--EAALEKQRQLA------EAHAQAKAQA--------------ERE 1367
Query: 312 AKELQGPWDLEKLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANL 371
AKELQ E + R+ + +D QK ++++ Q +++ +A +A
Sbjct: 1368 AKELQQRMQEEVVRRE-EAAVDAQQQK---RSIQEELQQLRQSSEAEIQAKARQAEAAER 1423
Query: 372 PNRTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPG 431
+ R L+A ERQR + + RAR + + Q
Sbjct: 1424 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ-------------- 1469
Query: 432 AAQRKLEELRRQ-----ERQRFAEYQ------AELQGI---QHRVQARPFLFQQAMQANA 477
AQ + E LRRQ +R+R AE + AE + Q +QA L QA +A
Sbjct: 1470 -AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1528
Query: 478 RL 479
RL
Sbjct: 1529 RL 1530
Score = 35.4 bits (80), Expect = 0.14
Identities = 83/329 (25%), Positives = 123/329 (37%), Gaps = 56/329 (17%)
Query: 215 VQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRK 274
V+LQ L A E +RG + G L Q R + E Q +A EEAE + + QRK
Sbjct: 1435 VRLQ-LEATERQRGGAEGEL-QALRARAEEAEAQKRQAQEEAERLRRQV----QDESQRK 1488
Query: 275 GQISGEEASD---EGEVQGQSQGSSPSFNNLRR---------RQWRKTRAKELQGPWDLE 322
Q E AS E E + Q + + LR RQ RA+++Q LE
Sbjct: 1489 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA--LE 1546
Query: 323 KLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEA 382
R + +L KT + ++ + A A +E A R+EA
Sbjct: 1547 TAQRSAEAELQSKRASFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1605
Query: 383 TRSL--------------LQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSR 428
R L LQA E +Q+ QAE + + + A R +R
Sbjct: 1606 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE-------------AEREAR 1652
Query: 429 GPGAA------QRKLEELRRQERQRFAE--YQAELQGIQHRVQARPFLFQQAMQANARLT 480
G A QR+L E +++++ AE Q L Q ++ R Q Q
Sbjct: 1653 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1712
Query: 481 VTRRFSQVLSALGLDEEQLLSEAGKVDRE 509
R + +A ++L +E KV E
Sbjct: 1713 ELARLQREAAAATQKRQELEAELAKVRAE 1741
Score = 33.5 bits (75), Expect = 0.53
Identities = 61/300 (20%), Positives = 110/300 (36%), Gaps = 26/300 (8%)
Query: 214 QVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQR 273
+ + A +AE L G + S+E+ EA + + RR A +
Sbjct: 1909 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1968
Query: 274 KGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLD 333
+ ++ EE E Q + + L+ + R +E ++ RQLQ +
Sbjct: 1969 QKSLAAEE-----EAARQRKAALEEVERLKAKVEEARRLRERAE----QESARQLQLAQE 2019
Query: 334 CGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKR---QEATRSLLQAW 390
++L + AF ++ + + E V L R +EA + +QA
Sbjct: 2020 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA- 2078
Query: 391 ERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEELRRQERQRFA- 449
ER+ + R+Q E Q + Q ++ AQ E+LR++ Q A
Sbjct: 2079 EREAAQSRRQVEEAERLKQSAEEQ------------AQARAQAQAAAEKLRKEAEQEAAR 2126
Query: 450 EYQAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQVLSALGLDEEQLLSEAGKVDRE 509
QAE ++ + A + + A L + Q L+ L L E+ + +D E
Sbjct: 2127 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2186
Score = 29.6 bits (65), Expect = 7.6
Identities = 30/83 (36%), Positives = 39/83 (46%), Gaps = 13/83 (15%)
Query: 380 QEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEE 439
QEATR +A Q+Q+E Q + R R Q + Q+A LA QR LE
Sbjct: 2298 QEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQ-------GFQRTLE- 2347
Query: 440 LRRQERQRFAEYQAELQGIQHRV 462
ERQR E AE + ++ RV
Sbjct: 2348 ---AERQRQLEMSAEAERLKLRV 2367
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 39.3 bits (90), Expect = 0.010
Identities = 84/362 (23%), Positives = 137/362 (37%), Gaps = 58/362 (16%)
Query: 133 QALPMPSSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELGS 192
QA+P+ S + R+ R+ A L E K E A+Q + A + +
Sbjct: 1220 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1279
Query: 193 EP-PSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSE 251
EP S + P + GS S + V L++ +E L+S + EEE+
Sbjct: 1280 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT--LTSQYIKFISETLRRMEEEERLA 1337
Query: 252 ATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTR 311
+ AEE E A +++ Q++ E Q ++Q +
Sbjct: 1338 EQQRAEERERLAEV--EAALEKQRQLA------EAHAQAKAQA--------------ERE 1375
Query: 312 AKELQGPWDLEKLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANL 371
AKELQ E + R+ + +D QK ++++ Q +++ +A +A
Sbjct: 1376 AKELQQRMQEEVVRRE-EAAVDAQQQK---RSIQEELQQLRQSSEAEIQAKARQAEAAER 1431
Query: 372 PNRTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPG 431
+ R L+A ERQR + + RAR + + Q
Sbjct: 1432 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ-------------- 1477
Query: 432 AAQRKLEELRRQ-----ERQRFAEYQ------AELQGI---QHRVQARPFLFQQAMQANA 477
AQ + E LRRQ +R+R AE + AE + Q +QA L QA +A
Sbjct: 1478 -AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1536
Query: 478 RL 479
RL
Sbjct: 1537 RL 1538
Score = 35.4 bits (80), Expect = 0.14
Identities = 83/329 (25%), Positives = 123/329 (37%), Gaps = 56/329 (17%)
Query: 215 VQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRK 274
V+LQ L A E +RG + G L Q R + E Q +A EEAE + + QRK
Sbjct: 1443 VRLQ-LEATERQRGGAEGEL-QALRARAEEAEAQKRQAQEEAERLRRQV----QDESQRK 1496
Query: 275 GQISGEEASD---EGEVQGQSQGSSPSFNNLRR---------RQWRKTRAKELQGPWDLE 322
Q E AS E E + Q + + LR RQ RA+++Q LE
Sbjct: 1497 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA--LE 1554
Query: 323 KLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEA 382
R + +L KT + ++ + A A +E A R+EA
Sbjct: 1555 TAQRSAEAELQSKRASFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1613
Query: 383 TRSL--------------LQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSR 428
R L LQA E +Q+ QAE + + + A R +R
Sbjct: 1614 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE-------------AEREAR 1660
Query: 429 GPGAA------QRKLEELRRQERQRFAE--YQAELQGIQHRVQARPFLFQQAMQANARLT 480
G A QR+L E +++++ AE Q L Q ++ R Q Q
Sbjct: 1661 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1720
Query: 481 VTRRFSQVLSALGLDEEQLLSEAGKVDRE 509
R + +A ++L +E KV E
Sbjct: 1721 ELARLQREAAAATQKRQELEAELAKVRAE 1749
Score = 33.5 bits (75), Expect = 0.53
Identities = 61/300 (20%), Positives = 110/300 (36%), Gaps = 26/300 (8%)
Query: 214 QVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQR 273
+ + A +AE L G + S+E+ EA + + RR A +
Sbjct: 1917 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1976
Query: 274 KGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLD 333
+ ++ EE E Q + + L+ + R +E ++ RQLQ +
Sbjct: 1977 QKSLAAEE-----EAARQRKAALEEVERLKAKVEEARRLRERAE----QESARQLQLAQE 2027
Query: 334 CGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKR---QEATRSLLQAW 390
++L + AF ++ + + E V L R +EA + +QA
Sbjct: 2028 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA- 2086
Query: 391 ERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEELRRQERQRFA- 449
ER+ + R+Q E Q + Q ++ AQ E+LR++ Q A
Sbjct: 2087 EREAAQSRRQVEEAERLKQSAEEQ------------AQARAQAQAAAEKLRKEAEQEAAR 2134
Query: 450 EYQAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQVLSALGLDEEQLLSEAGKVDRE 509
QAE ++ + A + + A L + Q L+ L L E+ + +D E
Sbjct: 2135 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2194
Score = 29.6 bits (65), Expect = 7.6
Identities = 30/83 (36%), Positives = 39/83 (46%), Gaps = 13/83 (15%)
Query: 380 QEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEE 439
QEATR +A Q+Q+E Q + R R Q + Q+A LA QR LE
Sbjct: 2306 QEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQ-------GFQRTLE- 2355
Query: 440 LRRQERQRFAEYQAELQGIQHRV 462
ERQR E AE + ++ RV
Sbjct: 2356 ---AERQRQLEMSAEAERLKLRV 2375
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 39.3 bits (90), Expect = 0.010
Identities = 84/362 (23%), Positives = 137/362 (37%), Gaps = 58/362 (16%)
Query: 133 QALPMPSSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELGS 192
QA+P+ S + R+ R+ A L E K E A+Q + A + +
Sbjct: 1261 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1320
Query: 193 EP-PSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSE 251
EP S + P + GS S + V L++ +E L+S + EEE+
Sbjct: 1321 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT--LTSQYIKFISETLRRMEEEERLA 1378
Query: 252 ATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTR 311
+ AEE E A +++ Q++ E Q ++Q +
Sbjct: 1379 EQQRAEERERLAEV--EAALEKQRQLA------EAHAQAKAQA--------------ERE 1416
Query: 312 AKELQGPWDLEKLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANL 371
AKELQ E + R+ + +D QK ++++ Q +++ +A +A
Sbjct: 1417 AKELQQRMQEEVVRRE-EAAVDAQQQK---RSIQEELQQLRQSSEAEIQAKARQAEAAER 1472
Query: 372 PNRTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPG 431
+ R L+A ERQR + + RAR + + Q
Sbjct: 1473 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ-------------- 1518
Query: 432 AAQRKLEELRRQ-----ERQRFAEYQ------AELQGI---QHRVQARPFLFQQAMQANA 477
AQ + E LRRQ +R+R AE + AE + Q +QA L QA +A
Sbjct: 1519 -AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1577
Query: 478 RL 479
RL
Sbjct: 1578 RL 1579
Score = 35.4 bits (80), Expect = 0.14
Identities = 83/329 (25%), Positives = 123/329 (37%), Gaps = 56/329 (17%)
Query: 215 VQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRK 274
V+LQ L A E +RG + G L Q R + E Q +A EEAE + + QRK
Sbjct: 1484 VRLQ-LEATERQRGGAEGEL-QALRARAEEAEAQKRQAQEEAERLRRQV----QDESQRK 1537
Query: 275 GQISGEEASD---EGEVQGQSQGSSPSFNNLRR---------RQWRKTRAKELQGPWDLE 322
Q E AS E E + Q + + LR RQ RA+++Q LE
Sbjct: 1538 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA--LE 1595
Query: 323 KLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEA 382
R + +L KT + ++ + A A +E A R+EA
Sbjct: 1596 TAQRSAEAELQSKRASFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1654
Query: 383 TRSL--------------LQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSR 428
R L LQA E +Q+ QAE + + + A R +R
Sbjct: 1655 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE-------------AEREAR 1701
Query: 429 GPGAA------QRKLEELRRQERQRFAE--YQAELQGIQHRVQARPFLFQQAMQANARLT 480
G A QR+L E +++++ AE Q L Q ++ R Q Q
Sbjct: 1702 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1761
Query: 481 VTRRFSQVLSALGLDEEQLLSEAGKVDRE 509
R + +A ++L +E KV E
Sbjct: 1762 ELARLQREAAAATQKRQELEAELAKVRAE 1790
Score = 33.5 bits (75), Expect = 0.53
Identities = 61/300 (20%), Positives = 110/300 (36%), Gaps = 26/300 (8%)
Query: 214 QVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQR 273
+ + A +AE L G + S+E+ EA + + RR A +
Sbjct: 1958 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV 2017
Query: 274 KGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLD 333
+ ++ EE E Q + + L+ + R +E ++ RQLQ +
Sbjct: 2018 QKSLAAEE-----EAARQRKAALEEVERLKAKVEEARRLRERAE----QESARQLQLAQE 2068
Query: 334 CGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKR---QEATRSLLQAW 390
++L + AF ++ + + E V L R +EA + +QA
Sbjct: 2069 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA- 2127
Query: 391 ERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEELRRQERQRFA- 449
ER+ + R+Q E Q + Q ++ AQ E+LR++ Q A
Sbjct: 2128 EREAAQSRRQVEEAERLKQSAEEQ------------AQARAQAQAAAEKLRKEAEQEAAR 2175
Query: 450 EYQAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQVLSALGLDEEQLLSEAGKVDRE 509
QAE ++ + A + + A L + Q L+ L L E+ + +D E
Sbjct: 2176 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEE 2235
Score = 29.6 bits (65), Expect = 7.6
Identities = 30/83 (36%), Positives = 39/83 (46%), Gaps = 13/83 (15%)
Query: 380 QEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEE 439
QEATR +A Q+Q+E Q + R R Q + Q+A LA QR LE
Sbjct: 2347 QEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQ-------GFQRTLE- 2396
Query: 440 LRRQERQRFAEYQAELQGIQHRV 462
ERQR E AE + ++ RV
Sbjct: 2397 ---AERQRQLEMSAEAERLKLRV 2416
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 38.5 bits (88), Expect = 0.016
Identities = 31/108 (28%), Positives = 49/108 (45%), Gaps = 8/108 (7%)
Query: 187 KGELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEE 246
+GE E +G + G G +++ + + G E+ E G G + + G EE
Sbjct: 772 EGERKKEERAGKEEKGEEEGDQGEGEEE-ETEGRGEEKEEGGEVEGGEVEEGK-GEREEE 829
Query: 247 EQFSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQG 294
E+ E EE EGE G + +G+ GEE +EGE G+ +G
Sbjct: 830 EEEGEGEEEEGEGEE----EEGEGEEEEGEGKGEEEGEEGE--GEEEG 871
Score = 36.6 bits (83), Expect = 0.062
Identities = 31/109 (28%), Positives = 45/109 (41%), Gaps = 10/109 (9%)
Query: 186 GKGELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISE 245
G+GE E G G G G +++ + + G EE E G + G E
Sbjct: 874 GEGEGEEEEGEG---EGEEEGEGEGEEEEGEGE--GEEEGE-----GEGEEEEGEGKGEE 923
Query: 246 EEQFSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQG 294
E + E E EEGE G + +G+ GEE EGE + + +G
Sbjct: 924 EGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEG 972
Score = 35.8 bits (81), Expect = 0.11
Identities = 30/111 (27%), Positives = 45/111 (40%), Gaps = 14/111 (12%)
Query: 191 GSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSS-GVLPQRPRRGSISEEEQF 249
G E G ++ G G ++ + + G EE G G + G EE +
Sbjct: 805 GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEE 864
Query: 250 SEATEEAEEGEHRTPCRRRAGCQRKGQISGEE------ASDEGEVQGQSQG 294
E EE EEGE G + +G+ GEE +EGE +G+ +G
Sbjct: 865 GEGEEEGEEGEGE-------GEEEEGEGEGEEEGEGEGEEEEGEGEGEEEG 908
Score = 34.3 bits (77), Expect = 0.31
Identities = 33/146 (22%), Positives = 55/146 (37%), Gaps = 9/146 (6%)
Query: 186 GKGELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISE 245
G+GE E G G G + + + + E E G G G
Sbjct: 928 GEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEG------EEGEGEG 981
Query: 246 EEQFSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSSPSFNNLRRR 305
EE+ E E EEGE + +G+ GEE +EGEV+G+ +G
Sbjct: 982 EEEEGEGEGEEEEGEEEG--EEEGEGEEEGEGEGEE-EEEGEVEGEVEGEEGEGEGEEEE 1038
Query: 306 QWRKTRAKELQGPWDLEKLHRQLQRD 331
+ +E +G + + +R+ + +
Sbjct: 1039 GEEEGEEREKEGEGEENRRNREEEEE 1064
Score = 33.5 bits (75), Expect = 0.53
Identities = 35/120 (29%), Positives = 48/120 (40%), Gaps = 18/120 (15%)
Query: 186 GKGELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQ-----RPRR 240
G+GE E G G G G +++ + G EE E G G +
Sbjct: 891 GEGEGEEEEGEG---EGEEEGEGEGEEEEGE--GKGEEEGEEGEGEGEEEEGEGEGEDGE 945
Query: 241 GSISEEEQFSEATEEA------EEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQG 294
G EEE E EE EEGE G + +G+ GEE +EGE +G+ +G
Sbjct: 946 GEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEE--EEGEEEGEEEG 1003
Score = 32.3 bits (72), Expect = 1.2
Identities = 32/118 (27%), Positives = 45/118 (38%), Gaps = 13/118 (11%)
Query: 170 KARQQLGAWGGVSIPTGKGELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGL 229
+ ++ G W G G+GE G E G G G +++ + + E E G
Sbjct: 947 EGEEEEGEWEGEE-EEGEGE-GEEEGEG----EGEEGEGEGEEEEGEGEGEEEEGEEEGE 1000
Query: 230 SSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGE 287
G + EEE E E EEGE G + +G+ GEE EGE
Sbjct: 1001 EEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGE-------GEEEEGEEEGEEREKEGE 1051
Score = 29.6 bits (65), Expect = 7.6
Identities = 24/91 (26%), Positives = 41/91 (45%), Gaps = 7/91 (7%)
Query: 208 GSASDKQVQLQSLGAEEAERGLSS-GVLPQRPRRGSISEEEQFSEATE---EAEEGEHRT 263
G ++ +++ G EE G G + + +EE E E E EEGE +
Sbjct: 718 GHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKK 777
Query: 264 PCRRRAGCQRKGQISGEEA-SDEGEVQGQSQ 293
RAG + KG+ G++ +E E +G+ +
Sbjct: 778 --EERAGKEEKGEEEGDQGEGEEEETEGRGE 806
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 38.5 bits (88), Expect = 0.016
Identities = 55/259 (21%), Positives = 96/259 (37%), Gaps = 33/259 (12%)
Query: 44 VSQDKQGCLGSGDGVPNQDLQQRSQSSRQTAKKDRKPRGQSKKGQGSEESEDHFPLLPRK 103
+S+ K+ GSG Q+ + R+ K+ R P+G+ +GS++ E P+K
Sbjct: 931 ISKKKKRRKGSGS---EQEGEDEEGGERKKKKRRRHPKGE----EGSDDDETENGPKPKK 983
Query: 104 PSFPFQWAWESIATD-----------VRAVLQPSSPTPGHQALPMPSSFSQRQSRRKSTA 152
P ++ + +A++ S + L + R S S +
Sbjct: 984 RRPPKAEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEGHPRNSNSNSDS 1043
Query: 153 NLPEAHGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELGSEPPSGLQLPGRRPGSGSASD 212
+ E C +E+ + + + + G+ G + + S RRP SD
Sbjct: 1044 DEDEQRKKCASSESDSDENQNKSGSEAGSPRRPRRQRSDQDSDSDQPSRKRRPSGSEQSD 1103
Query: 213 KQVQLQSLGAEEAERGLS-SGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGC 271
E + G S SGV R S S +E+ E+E G + +G
Sbjct: 1104 N---------ESVQSGRSHSGVSENDSRPASPS-----AESDHESERGSDNEGSGQGSGN 1149
Query: 272 QRKGQISGEEASDEGEVQG 290
+ + + S EASD G G
Sbjct: 1150 ESEPEGSNNEASDRGSEHG 1168
>gi|92091575 coiled-coil domain containing 57 [Homo sapiens]
Length = 915
Score = 38.1 bits (87), Expect = 0.021
Identities = 28/116 (24%), Positives = 54/116 (46%), Gaps = 9/116 (7%)
Query: 387 LQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEELRRQERQ 446
L+ ++ + R+ E RRA ++ + A A A RK+EEL++Q++
Sbjct: 71 LERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREA--------RKVEELQQQQQL 122
Query: 447 RFAEYQAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQVLSALGLDEEQLLSE 502
F E++ EL+ + H + + N + T+ R+ ++ L L ++LL E
Sbjct: 123 AFQEHRLELERV-HSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLE 177
>gi|224809410 Homer, neuronal immediate early gene, 3 isoform 2
[Homo sapiens]
Length = 358
Score = 37.7 bits (86), Expect = 0.028
Identities = 55/270 (20%), Positives = 97/270 (35%), Gaps = 35/270 (12%)
Query: 241 GSISEEE--QFSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSSPS 298
G SE+ QF+E +E +E +++ E++ D GE+ + G
Sbjct: 92 GFASEQHLTQFAEKFQEVKEA---------------ARLAREKSQDGGELTSPALG---- 132
Query: 299 FNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAY 358
L Q + GP + EKL R D P T R + G
Sbjct: 133 ---LASHQVPPSPLVSANGPGE-EKLFRSQSADA-------PGPTERERLKKMLSEGSVG 181
Query: 359 ASGYDETFVSANLPNRTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHC 418
++ F + N + W +Q + +R +AE R R ++ Q A
Sbjct: 182 EVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASE 241
Query: 419 LAAYAPRGSRGPGAAQRKLEELRRQERQRFAEYQAELQGIQHRVQA--RPFLFQQAMQAN 476
+ + G G + +LE L + + Q +++ G + ++A R Q+ N
Sbjct: 242 VTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRN 301
Query: 477 ARLT-VTRRFSQVLSALGLDEEQLLSEAGK 505
A L R + L + E+ +E G+
Sbjct: 302 AELEHQLRAMERSLEEARAERERARAEVGR 331
>gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [Homo
sapiens]
Length = 1336
Score = 37.7 bits (86), Expect = 0.028
Identities = 62/311 (19%), Positives = 117/311 (37%), Gaps = 31/311 (9%)
Query: 241 GSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSSPSFN 300
GS+ +E++ + +E +E P +RR+ C+ + +E S + G + S +
Sbjct: 745 GSLLKEQKMNRDNKEGQE-----PAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVH 799
Query: 301 NLRRRQWRK-------TRAKELQ-GPWDLEKLHRQLQRDLDCGPQKLPWKTLRAAFQASK 352
++R++ K RA LQ P L + P W++ FQ
Sbjct: 800 LRKKRKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSSLSPW---WRSSLTYFQQQL 856
Query: 353 RNGKAYASGYDETFVSANLPNRTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQ 412
+ GK D+ F + R L+ ++++ ++E +A + + H
Sbjct: 857 KPGKE-----DKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDH-- 909
Query: 413 RQVAHCLAAYAPRGSRGPGAAQRKLEELRRQERQRFAEYQAEL-QGIQHRVQARPFLFQQ 471
+ + A + G+ GP ++K ++RR+ R E EL + + H +Q
Sbjct: 910 SRSSSPTAGPSTEGAEGP--EEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLAN 967
Query: 472 AMQANARLTVTRRFSQVLSALGLDEEQLLSEAGKVDREGTPRKPRSHRSMGVRMEHSPQR 531
Q + + G+ E G GTPR+ R +G + P+
Sbjct: 968 ENQQPIKSEPESEGEEPKRPPGICERPHRFSKG---LNGTPRELR--HQLGPSLRSPPRV 1022
Query: 532 PPRTEPTGSQP 542
R P+ S P
Sbjct: 1023 ISRPPPSVSPP 1033
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 37.4 bits (85), Expect = 0.036
Identities = 47/199 (23%), Positives = 79/199 (39%), Gaps = 22/199 (11%)
Query: 370 NLPN-----RTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAP 424
NLP R F + Q A + +A RQ+ E++Q+ R +RQ
Sbjct: 343 NLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKR---IEEQK 399
Query: 425 RGSRGPGAAQRKLEELRR-QERQRFAEYQAELQGIQHRVQARPFLFQQAMQANARLTVTR 483
R QR+ +ELR+ QER++ Y+ +++ + R +A + +L +
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAE----HEQEYIRRQLEEEQ 455
Query: 484 RFSQVLSALGLDEEQLLSEAGKV------DREGTPRKPRSHRSMGVRMEHSPQRPPRTEP 537
R ++L L E+ LL E + E R+ + R V ++H Q P
Sbjct: 456 RQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQ---EQRP 512
Query: 538 TGSQPDRHYNPSLDPECSP 556
+P HY + P P
Sbjct: 513 VEKKPLYHYKEGMSPSEKP 531
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 37.4 bits (85), Expect = 0.036
Identities = 47/199 (23%), Positives = 79/199 (39%), Gaps = 22/199 (11%)
Query: 370 NLPN-----RTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAP 424
NLP R F + Q A + +A RQ+ E++Q+ R +RQ
Sbjct: 343 NLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKR---IEEQK 399
Query: 425 RGSRGPGAAQRKLEELRR-QERQRFAEYQAELQGIQHRVQARPFLFQQAMQANARLTVTR 483
R QR+ +ELR+ QER++ Y+ +++ + R +A + +L +
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAE----HEQEYIRRQLEEEQ 455
Query: 484 RFSQVLSALGLDEEQLLSEAGKV------DREGTPRKPRSHRSMGVRMEHSPQRPPRTEP 537
R ++L L E+ LL E + E R+ + R V ++H Q P
Sbjct: 456 RQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQ---EQRP 512
Query: 538 TGSQPDRHYNPSLDPECSP 556
+P HY + P P
Sbjct: 513 VEKKPLYHYKEGMSPSEKP 531
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 37.4 bits (85), Expect = 0.036
Identities = 47/199 (23%), Positives = 79/199 (39%), Gaps = 22/199 (11%)
Query: 370 NLPN-----RTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAP 424
NLP R F + Q A + +A RQ+ E++Q+ R +RQ
Sbjct: 343 NLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKR---IEEQK 399
Query: 425 RGSRGPGAAQRKLEELRR-QERQRFAEYQAELQGIQHRVQARPFLFQQAMQANARLTVTR 483
R QR+ +ELR+ QER++ Y+ +++ + R +A + +L +
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAE----HEQEYIRRQLEEEQ 455
Query: 484 RFSQVLSALGLDEEQLLSEAGKV------DREGTPRKPRSHRSMGVRMEHSPQRPPRTEP 537
R ++L L E+ LL E + E R+ + R V ++H Q P
Sbjct: 456 RQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQ---EQRP 512
Query: 538 TGSQPDRHYNPSLDPECSP 556
+P HY + P P
Sbjct: 513 VEKKPLYHYKEGMSPSEKP 531
Score = 30.8 bits (68), Expect = 3.4
Identities = 42/186 (22%), Positives = 78/186 (41%), Gaps = 34/186 (18%)
Query: 378 KRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKL 437
+R++ R + +R+ EE+ + E R R +H Q + L QR+L
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLE-----------EEQRQL 458
Query: 438 EELRRQ---ERQRFAEY-------QAELQGIQHRV-QARPFLFQQAMQANARLTVTRR-F 485
E L++Q E+ EY Q + + +Q ++ Q R +L Q + V ++
Sbjct: 459 EILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPL 518
Query: 486 SQVLSALGLDEE----QLLSEAGKVDREGTPRKPRSHRSMGVRMEHSPQRPPRTEP---T 538
+ E+ + + E +++R+ +P P + R+ P PPR+E +
Sbjct: 519 YHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMP---HKVANRIS-DPNLPPRSESFSIS 574
Query: 539 GSQPDR 544
G QP R
Sbjct: 575 GVQPAR 580
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 37.4 bits (85), Expect = 0.036
Identities = 47/199 (23%), Positives = 79/199 (39%), Gaps = 22/199 (11%)
Query: 370 NLPN-----RTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAP 424
NLP R F + Q A + +A RQ+ E++Q+ R +RQ
Sbjct: 343 NLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKR---IEEQK 399
Query: 425 RGSRGPGAAQRKLEELRR-QERQRFAEYQAELQGIQHRVQARPFLFQQAMQANARLTVTR 483
R QR+ +ELR+ QER++ Y+ +++ + R +A + +L +
Sbjct: 400 EQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAE----HEQEYIRRQLEEEQ 455
Query: 484 RFSQVLSALGLDEEQLLSEAGKV------DREGTPRKPRSHRSMGVRMEHSPQRPPRTEP 537
R ++L L E+ LL E + E R+ + R V ++H Q P
Sbjct: 456 RQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQ---EQRP 512
Query: 538 TGSQPDRHYNPSLDPECSP 556
+P HY + P P
Sbjct: 513 VEKKPLYHYKEGMSPSEKP 531
Score = 30.8 bits (68), Expect = 3.4
Identities = 42/186 (22%), Positives = 78/186 (41%), Gaps = 34/186 (18%)
Query: 378 KRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKL 437
+R++ R + +R+ EE+ + E R R +H Q + L QR+L
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLE-----------EEQRQL 458
Query: 438 EELRRQ---ERQRFAEY-------QAELQGIQHRV-QARPFLFQQAMQANARLTVTRR-F 485
E L++Q E+ EY Q + + +Q ++ Q R +L Q + V ++
Sbjct: 459 EILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPL 518
Query: 486 SQVLSALGLDEE----QLLSEAGKVDREGTPRKPRSHRSMGVRMEHSPQRPPRTEP---T 538
+ E+ + + E +++R+ +P P + R+ P PPR+E +
Sbjct: 519 YHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMP---HKVANRIS-DPNLPPRSESFSIS 574
Query: 539 GSQPDR 544
G QP R
Sbjct: 575 GVQPAR 580
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,656,396
Number of Sequences: 37866
Number of extensions: 1295299
Number of successful extensions: 7197
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 50
Number of HSP's successfully gapped in prelim test: 348
Number of HSP's that attempted gapping in prelim test: 6156
Number of HSP's gapped (non-prelim): 1046
length of query: 556
length of database: 18,247,518
effective HSP length: 107
effective length of query: 449
effective length of database: 14,195,856
effective search space: 6373939344
effective search space used: 6373939344
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.