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Search of human proteins with 153792133
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153792133 inhibitor of kappa light polypeptide gene enhancer
in B-cells, kinase gamma isoform a [Homo sapiens]
(419 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223671870 inhibitor of kappa light polypeptide gene enhancer ... 819 0.0
gi|4504631 inhibitor of kappa light polypeptide gene enhancer in... 819 0.0
gi|153792133 inhibitor of kappa light polypeptide gene enhancer ... 819 0.0
gi|223671872 inhibitor of kappa light polypeptide gene enhancer ... 362 e-100
gi|56549111 optineurin [Homo sapiens] 142 6e-34
gi|56549109 optineurin [Homo sapiens] 142 6e-34
gi|20149572 optineurin [Homo sapiens] 142 6e-34
gi|56549107 optineurin [Homo sapiens] 142 6e-34
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 83 5e-16
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 83 5e-16
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 83 5e-16
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 83 5e-16
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 83 5e-16
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 83 5e-16
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 83 5e-16
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 83 5e-16
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 75 1e-13
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 75 1e-13
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 75 1e-13
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 74 2e-13
gi|21450705 leucine rich repeat containing 45 [Homo sapiens] 73 5e-13
gi|21735548 centrosomal protein 2 [Homo sapiens] 72 1e-12
gi|115511012 coiled-coil domain containing 136 [Homo sapiens] 72 1e-12
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 71 2e-12
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 70 3e-12
gi|58530840 desmoplakin isoform I [Homo sapiens] 70 3e-12
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 70 3e-12
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 70 3e-12
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 70 4e-12
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 70 4e-12
>gi|223671870 inhibitor of kappa light polypeptide gene enhancer in
B-cells, kinase gamma isoform b [Homo sapiens]
Length = 487
Score = 819 bits (2115), Expect = 0.0
Identities = 419/419 (100%), Positives = 419/419 (100%)
Query: 1 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE 60
MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE
Sbjct: 69 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE 128
Query: 61 LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ 120
LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ
Sbjct: 129 LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ 188
Query: 121 ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQ 180
ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQ
Sbjct: 189 ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQ 248
Query: 181 ARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQE 240
ARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQE
Sbjct: 249 ARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQE 308
Query: 241 YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPV 300
YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPV
Sbjct: 309 YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPV 368
Query: 301 LKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH 360
LKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH
Sbjct: 369 LKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH 428
Query: 361 VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE 419
VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE
Sbjct: 429 VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE 487
>gi|4504631 inhibitor of kappa light polypeptide gene enhancer in
B-cells, kinase gamma isoform a [Homo sapiens]
Length = 419
Score = 819 bits (2115), Expect = 0.0
Identities = 419/419 (100%), Positives = 419/419 (100%)
Query: 1 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE 60
MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE
Sbjct: 1 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE 60
Query: 61 LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ 120
LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ
Sbjct: 61 LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ 120
Query: 121 ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQ 180
ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQ
Sbjct: 121 ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQ 180
Query: 181 ARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQE 240
ARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQE
Sbjct: 181 ARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQE 240
Query: 241 YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPV 300
YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPV
Sbjct: 241 YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPV 300
Query: 301 LKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH 360
LKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH
Sbjct: 301 LKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH 360
Query: 361 VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE 419
VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE
Sbjct: 361 VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE 419
>gi|153792133 inhibitor of kappa light polypeptide gene enhancer in
B-cells, kinase gamma isoform a [Homo sapiens]
Length = 419
Score = 819 bits (2115), Expect = 0.0
Identities = 419/419 (100%), Positives = 419/419 (100%)
Query: 1 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE 60
MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE
Sbjct: 1 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE 60
Query: 61 LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ 120
LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ
Sbjct: 61 LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ 120
Query: 121 ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQ 180
ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQ
Sbjct: 121 ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQ 180
Query: 181 ARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQE 240
ARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQE
Sbjct: 181 ARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQE 240
Query: 241 YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPV 300
YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPV
Sbjct: 241 YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPV 300
Query: 301 LKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH 360
LKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH
Sbjct: 301 LKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH 360
Query: 361 VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE 419
VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE
Sbjct: 361 VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE 419
>gi|223671872 inhibitor of kappa light polypeptide gene enhancer in
B-cells, kinase gamma isoform c [Homo sapiens]
Length = 320
Score = 362 bits (928), Expect = e-100
Identities = 198/273 (72%), Positives = 216/273 (79%), Gaps = 6/273 (2%)
Query: 1 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE 60
MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE
Sbjct: 1 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE 60
Query: 61 LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ 120
LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ
Sbjct: 61 LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ 120
Query: 121 ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQ 180
ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGR + A Q
Sbjct: 121 ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQ 180
Query: 181 ARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQE 240
+ +E S V R + +A + ERQA + K LQ QL +E
Sbjct: 181 VAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQRE 240
Query: 241 YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEA 273
Y + +K+S S R +ED++++ + +A
Sbjct: 241 Y-SKLKASCQESAR-----IEDMRKRHVEVSQA 267
>gi|56549111 optineurin [Homo sapiens]
Length = 577
Score = 142 bits (358), Expect = 6e-34
Identities = 103/339 (30%), Positives = 186/339 (54%), Gaps = 15/339 (4%)
Query: 88 EEKEFLMCKFQEARKLV---ERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKA 144
++ E L +EA++ V E+ + +++ Q E + + ++ + + + ++
Sbjct: 245 QKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNL 304
Query: 145 QVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQ-LR 203
QVTSL ELQE+ ++L A + L+ + +A + + SE ++Q V ++ L
Sbjct: 305 QVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELN--EKQELVYTNKKLE 362
Query: 204 MQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKS----SVVGSERKRGMQ 259
+Q +S+ + ++ME+ +EK KL LQ+ +++L QE++N +K+ + SE+
Sbjct: 363 LQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAV 422
Query: 260 LEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAR 319
L++L ++L+ AE+AL +KQ +D++K+ + + +ET+ +L+AQ ++Y +DF AER AR
Sbjct: 423 LKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAR 482
Query: 320 EKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPL 379
EK+ E+KE L QL L +E + ++S + +M+ RH ++ AYL
Sbjct: 483 EKIHEEKEQLALQLAVLLKENDAFEDGGRQS--LMEMQSRH--GARTSDSDQQAYLVQRG 538
Query: 380 ALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECI 418
A R P CPKC PD+DTLQIHVM+CI
Sbjct: 539 AEDRDWRQ-QRNIPIHSCPKCGEVLPDIDTLQIHVMDCI 576
Score = 67.0 bits (162), Expect = 3e-11
Identities = 109/465 (23%), Positives = 188/465 (40%), Gaps = 72/465 (15%)
Query: 15 QPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETL----QRCLEENQELRDAIRQSNQ 70
QP +D E + G P + H + PE L + L EN +L++A++ +NQ
Sbjct: 4 QPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQ 63
Query: 71 ILRERCEELLHFQASQREEKEF-----------LMCKFQEARKLVERLGLEKLDLKRQKE 119
++ R EEL + Q+EE++F LM E KL E LG K +R E
Sbjct: 64 AMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSE 123
Query: 120 QALREVEHLKRCQQQMAEDK-----ASVKAQVTSLLGELQESQSRL------EAATKECQ 168
+ L R + + +D+ ++A+ LLG + E Q +L E + E +
Sbjct: 124 DPTDD-SRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIR 182
Query: 169 ALEGRARAASEQAR------QLESEREALQQQHSVQVDQ------------------LRM 204
EG A + ++ + + S AL + S D LR
Sbjct: 183 MAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLRE 242
Query: 205 QGQSV---EAALRMERQAASEEKRKLAQLQVAYHQ----LFQEYDNHIKSSVVGSE-RKR 256
Q V E AL+ ++ S+ ++K + Q +E D VGSE
Sbjct: 243 GNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEAL 302
Query: 257 GMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVP-VLKAQADIYKADFQAE 315
+Q+ L ++LQ+A L + + +L+E+ + + +P L + ++ + + E
Sbjct: 303 NLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLE 362
Query: 316 RQAREKLAE------KKELLQEQLEQLQREYSKLKASCQESAR-IEDM-RKRHVEVSQAP 367
Q L+E K E + +L LQ ++KL + + IE++ RK +V +A
Sbjct: 363 LQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAV 422
Query: 368 LPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQI 412
L LS L L + + + D Q D++T+ I
Sbjct: 423 LKE----LSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTI 463
>gi|56549109 optineurin [Homo sapiens]
Length = 577
Score = 142 bits (358), Expect = 6e-34
Identities = 103/339 (30%), Positives = 186/339 (54%), Gaps = 15/339 (4%)
Query: 88 EEKEFLMCKFQEARKLV---ERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKA 144
++ E L +EA++ V E+ + +++ Q E + + ++ + + + ++
Sbjct: 245 QKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNL 304
Query: 145 QVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQ-LR 203
QVTSL ELQE+ ++L A + L+ + +A + + SE ++Q V ++ L
Sbjct: 305 QVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELN--EKQELVYTNKKLE 362
Query: 204 MQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKS----SVVGSERKRGMQ 259
+Q +S+ + ++ME+ +EK KL LQ+ +++L QE++N +K+ + SE+
Sbjct: 363 LQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAV 422
Query: 260 LEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAR 319
L++L ++L+ AE+AL +KQ +D++K+ + + +ET+ +L+AQ ++Y +DF AER AR
Sbjct: 423 LKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAR 482
Query: 320 EKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPL 379
EK+ E+KE L QL L +E + ++S + +M+ RH ++ AYL
Sbjct: 483 EKIHEEKEQLALQLAVLLKENDAFEDGGRQS--LMEMQSRH--GARTSDSDQQAYLVQRG 538
Query: 380 ALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECI 418
A R P CPKC PD+DTLQIHVM+CI
Sbjct: 539 AEDRDWRQ-QRNIPIHSCPKCGEVLPDIDTLQIHVMDCI 576
Score = 67.0 bits (162), Expect = 3e-11
Identities = 109/465 (23%), Positives = 188/465 (40%), Gaps = 72/465 (15%)
Query: 15 QPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETL----QRCLEENQELRDAIRQSNQ 70
QP +D E + G P + H + PE L + L EN +L++A++ +NQ
Sbjct: 4 QPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQ 63
Query: 71 ILRERCEELLHFQASQREEKEF-----------LMCKFQEARKLVERLGLEKLDLKRQKE 119
++ R EEL + Q+EE++F LM E KL E LG K +R E
Sbjct: 64 AMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSE 123
Query: 120 QALREVEHLKRCQQQMAEDK-----ASVKAQVTSLLGELQESQSRL------EAATKECQ 168
+ L R + + +D+ ++A+ LLG + E Q +L E + E +
Sbjct: 124 DPTDD-SRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIR 182
Query: 169 ALEGRARAASEQAR------QLESEREALQQQHSVQVDQ------------------LRM 204
EG A + ++ + + S AL + S D LR
Sbjct: 183 MAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLRE 242
Query: 205 QGQSV---EAALRMERQAASEEKRKLAQLQVAYHQ----LFQEYDNHIKSSVVGSE-RKR 256
Q V E AL+ ++ S+ ++K + Q +E D VGSE
Sbjct: 243 GNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEAL 302
Query: 257 GMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVP-VLKAQADIYKADFQAE 315
+Q+ L ++LQ+A L + + +L+E+ + + +P L + ++ + + E
Sbjct: 303 NLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLE 362
Query: 316 RQAREKLAE------KKELLQEQLEQLQREYSKLKASCQESAR-IEDM-RKRHVEVSQAP 367
Q L+E K E + +L LQ ++KL + + IE++ RK +V +A
Sbjct: 363 LQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAV 422
Query: 368 LPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQI 412
L LS L L + + + D Q D++T+ I
Sbjct: 423 LKE----LSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTI 463
>gi|20149572 optineurin [Homo sapiens]
Length = 577
Score = 142 bits (358), Expect = 6e-34
Identities = 103/339 (30%), Positives = 186/339 (54%), Gaps = 15/339 (4%)
Query: 88 EEKEFLMCKFQEARKLV---ERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKA 144
++ E L +EA++ V E+ + +++ Q E + + ++ + + + ++
Sbjct: 245 QKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNL 304
Query: 145 QVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQ-LR 203
QVTSL ELQE+ ++L A + L+ + +A + + SE ++Q V ++ L
Sbjct: 305 QVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELN--EKQELVYTNKKLE 362
Query: 204 MQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKS----SVVGSERKRGMQ 259
+Q +S+ + ++ME+ +EK KL LQ+ +++L QE++N +K+ + SE+
Sbjct: 363 LQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAV 422
Query: 260 LEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAR 319
L++L ++L+ AE+AL +KQ +D++K+ + + +ET+ +L+AQ ++Y +DF AER AR
Sbjct: 423 LKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAR 482
Query: 320 EKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPL 379
EK+ E+KE L QL L +E + ++S + +M+ RH ++ AYL
Sbjct: 483 EKIHEEKEQLALQLAVLLKENDAFEDGGRQS--LMEMQSRH--GARTSDSDQQAYLVQRG 538
Query: 380 ALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECI 418
A R P CPKC PD+DTLQIHVM+CI
Sbjct: 539 AEDRDWRQ-QRNIPIHSCPKCGEVLPDIDTLQIHVMDCI 576
Score = 67.0 bits (162), Expect = 3e-11
Identities = 109/465 (23%), Positives = 188/465 (40%), Gaps = 72/465 (15%)
Query: 15 QPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETL----QRCLEENQELRDAIRQSNQ 70
QP +D E + G P + H + PE L + L EN +L++A++ +NQ
Sbjct: 4 QPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQ 63
Query: 71 ILRERCEELLHFQASQREEKEF-----------LMCKFQEARKLVERLGLEKLDLKRQKE 119
++ R EEL + Q+EE++F LM E KL E LG K +R E
Sbjct: 64 AMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSE 123
Query: 120 QALREVEHLKRCQQQMAEDK-----ASVKAQVTSLLGELQESQSRL------EAATKECQ 168
+ L R + + +D+ ++A+ LLG + E Q +L E + E +
Sbjct: 124 DPTDD-SRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIR 182
Query: 169 ALEGRARAASEQAR------QLESEREALQQQHSVQVDQ------------------LRM 204
EG A + ++ + + S AL + S D LR
Sbjct: 183 MAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLRE 242
Query: 205 QGQSV---EAALRMERQAASEEKRKLAQLQVAYHQ----LFQEYDNHIKSSVVGSE-RKR 256
Q V E AL+ ++ S+ ++K + Q +E D VGSE
Sbjct: 243 GNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEAL 302
Query: 257 GMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVP-VLKAQADIYKADFQAE 315
+Q+ L ++LQ+A L + + +L+E+ + + +P L + ++ + + E
Sbjct: 303 NLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLE 362
Query: 316 RQAREKLAE------KKELLQEQLEQLQREYSKLKASCQESAR-IEDM-RKRHVEVSQAP 367
Q L+E K E + +L LQ ++KL + + IE++ RK +V +A
Sbjct: 363 LQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAV 422
Query: 368 LPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQI 412
L LS L L + + + D Q D++T+ I
Sbjct: 423 LKE----LSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTI 463
>gi|56549107 optineurin [Homo sapiens]
Length = 577
Score = 142 bits (358), Expect = 6e-34
Identities = 103/339 (30%), Positives = 186/339 (54%), Gaps = 15/339 (4%)
Query: 88 EEKEFLMCKFQEARKLV---ERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKA 144
++ E L +EA++ V E+ + +++ Q E + + ++ + + + ++
Sbjct: 245 QKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNL 304
Query: 145 QVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQ-LR 203
QVTSL ELQE+ ++L A + L+ + +A + + SE ++Q V ++ L
Sbjct: 305 QVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELN--EKQELVYTNKKLE 362
Query: 204 MQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKS----SVVGSERKRGMQ 259
+Q +S+ + ++ME+ +EK KL LQ+ +++L QE++N +K+ + SE+
Sbjct: 363 LQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAV 422
Query: 260 LEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAR 319
L++L ++L+ AE+AL +KQ +D++K+ + + +ET+ +L+AQ ++Y +DF AER AR
Sbjct: 423 LKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAR 482
Query: 320 EKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPL 379
EK+ E+KE L QL L +E + ++S + +M+ RH ++ AYL
Sbjct: 483 EKIHEEKEQLALQLAVLLKENDAFEDGGRQS--LMEMQSRH--GARTSDSDQQAYLVQRG 538
Query: 380 ALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECI 418
A R P CPKC PD+DTLQIHVM+CI
Sbjct: 539 AEDRDWRQ-QRNIPIHSCPKCGEVLPDIDTLQIHVMDCI 576
Score = 67.0 bits (162), Expect = 3e-11
Identities = 109/465 (23%), Positives = 188/465 (40%), Gaps = 72/465 (15%)
Query: 15 QPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETL----QRCLEENQELRDAIRQSNQ 70
QP +D E + G P + H + PE L + L EN +L++A++ +NQ
Sbjct: 4 QPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQ 63
Query: 71 ILRERCEELLHFQASQREEKEF-----------LMCKFQEARKLVERLGLEKLDLKRQKE 119
++ R EEL + Q+EE++F LM E KL E LG K +R E
Sbjct: 64 AMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSE 123
Query: 120 QALREVEHLKRCQQQMAEDK-----ASVKAQVTSLLGELQESQSRL------EAATKECQ 168
+ L R + + +D+ ++A+ LLG + E Q +L E + E +
Sbjct: 124 DPTDD-SRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIR 182
Query: 169 ALEGRARAASEQAR------QLESEREALQQQHSVQVDQ------------------LRM 204
EG A + ++ + + S AL + S D LR
Sbjct: 183 MAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLRE 242
Query: 205 QGQSV---EAALRMERQAASEEKRKLAQLQVAYHQ----LFQEYDNHIKSSVVGSE-RKR 256
Q V E AL+ ++ S+ ++K + Q +E D VGSE
Sbjct: 243 GNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEAL 302
Query: 257 GMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVP-VLKAQADIYKADFQAE 315
+Q+ L ++LQ+A L + + +L+E+ + + +P L + ++ + + E
Sbjct: 303 NLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLE 362
Query: 316 RQAREKLAE------KKELLQEQLEQLQREYSKLKASCQESAR-IEDM-RKRHVEVSQAP 367
Q L+E K E + +L LQ ++KL + + IE++ RK +V +A
Sbjct: 363 LQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAV 422
Query: 368 LPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQI 412
L LS L L + + + D Q D++T+ I
Sbjct: 423 LKE----LSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTI 463
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 82.8 bits (203), Expect = 5e-16
Identities = 93/338 (27%), Positives = 155/338 (45%), Gaps = 38/338 (11%)
Query: 45 QGAPETLQRCLEENQELR-DAIRQSNQILR-----ERCEELLHFQASQREEKEFLMCKFQ 98
+G E +R EE +E R A R++ Q R ER ++ QA R + + K +
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 99 -EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQ 157
EA + R + RQK+ A E+E K+ +Q KA V+ ++T+L +L+E+
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 158 SRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMER 217
+ +E Q L+ A A+ Q Q+E E +++ VQ+++L +EA R
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEELSKLKARIEAENRALI 2255
Query: 218 QAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL--EDLKQQLQQAEEALV 275
+ ++ LQ ++ Q + + SV E R QL EDL QQ AE+ L
Sbjct: 2256 LRDKDNTQRF--LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2313
Query: 276 AKQEVID---KLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQ 332
K + + +LK EAE +L+ Q ++ A+ QAR +K+++ Q+
Sbjct: 2314 EKMQAVQEATRLKAEAE----------LLQQQKEL------AQEQARRLQEDKEQMAQQL 2357
Query: 333 LEQLQREYSKLKASCQE----SARIEDMRKRHVEVSQA 366
E+ Q L+A Q SA E ++ R E+S+A
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2395
Score = 77.8 bits (190), Expect = 2e-14
Identities = 82/322 (25%), Positives = 152/322 (47%), Gaps = 49/322 (15%)
Query: 56 EENQELRDAIR-QSNQILRERCEELLHFQASQ-REEKEFLMCKFQEA----RKLVERLGL 109
E+ Q +++A R ++ L ++ +EL QA + +E+KE + + E ++ +E
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 110 EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKE--- 166
+L++ + E+ V + R Q + ED + Q E+ E R E AT+E
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEKVT 2429
Query: 167 -CQALEGRARAASEQAR-------QLESEREALQQQ-----------HSVQVDQLRMQGQ 207
Q LE + + + A +LE E+E LQQ+ +VQ +QL + Q
Sbjct: 2430 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2489
Query: 208 SVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQL 267
+++ + E+ + + +R + Q + QLFQ D K+ + E++R +QQ+
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ--DEVAKAQQLREEQQRQ------QQQM 2541
Query: 268 QQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKE 327
+Q + LVA E + + EAE+ V + Q ++ + + Q RQ E LAE+ +
Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEG--------VRRKQEELQQLE-QQRRQQEELLAEENQ 2592
Query: 328 LLQEQLEQLQREYSKLKASCQE 349
L+EQL+ L+ ++ A +E
Sbjct: 2593 RLREQLQLLEEQHRAALAHSEE 2614
Score = 74.7 bits (182), Expect = 1e-13
Identities = 88/360 (24%), Positives = 154/360 (42%), Gaps = 62/360 (17%)
Query: 27 LGEESPLGKPAMLHLPSEQGAPETLQRCLEEN----QELRDAIRQSNQILRERCEELLHF 82
+GE + L A + L ++ E L+R E+ + L + Q + ER +L
Sbjct: 1842 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901
Query: 83 QASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASV 142
S+ E + + LVE D RQ+ Q E+ LK ++ A KA +
Sbjct: 1902 SDSELERQ----------KGLVE-------DTLRQRRQVEEEILALKASFEKAAAGKAEL 1944
Query: 143 KAQVTSLLGELQES-----QSRLEAATKECQALEG--RARAASEQARQLESEREALQQQH 195
+ ++ + +++ Q+ LEAA + A E R R A E+ ++ + E +Q
Sbjct: 1945 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 2004
Query: 196 SVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 255
++++ VE A R+ +A E R+L Q A + Q E+
Sbjct: 2005 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ-----------AEEKA 2053
Query: 256 RGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAE 315
++ +Q+LQQ L +Q V+D+L+ EAE + +A + +A QAE
Sbjct: 2054 HAFAVQQKEQELQQT---LQQEQSVLDQLRGEAEAAR---------RAAEEAEEARVQAE 2101
Query: 316 RQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRK-------RHVEVSQAPL 368
R+A + + +E E+L+Q E ++ +A Q +A E +RK R + QA L
Sbjct: 2102 REAAQSRRQVEE--AERLKQSAEEQAQARAQAQAAA--EKLRKEAEQEAARRAQAEQAAL 2157
Score = 74.3 bits (181), Expect = 2e-13
Identities = 96/388 (24%), Positives = 164/388 (42%), Gaps = 66/388 (17%)
Query: 41 LPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEE------LLHFQASQR----EEK 90
L +E+ A + LEE + L+ + ++ + LRER E+ L +A+Q+ EEK
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARR-LRERAEQESARQLQLAQEAAQKRLQAEEK 2052
Query: 91 EFLMCKFQEARKLVERLGLEK--LD-LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVT 147
Q+ ++L + L E+ LD L+ + E A R E + + Q + A + QV
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2112
Query: 148 SLLGELQESQSRLEAATKECQALEG-RARAASEQARQLESEREALQQQHSVQVDQLRMQG 206
Q ++ + +A + A E R A E AR+ ++E+ AL+Q+ + + +
Sbjct: 2113 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE-MEKHK 2171
Query: 207 QSVEAALRMERQAASEEKRKLAQLQVAYHQ--LFQEYDNHIKSSVVGSERKRGM------ 258
+ E LR + Q E QL+ HQ L E +K+ + R+R
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2231
Query: 259 -------QLEDLKQQLQQAEEALVA--KQEVIDKLKEEAEQHKIVMETVPVLK------- 302
+L LK +++ AL+ K L+EEAE+ K V E L
Sbjct: 2232 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2291
Query: 303 -----AQADIYKADFQAERQAREK----------------LAEKKELLQEQLEQLQREYS 341
A+ D+ + AE+ +EK L ++KEL QEQ +LQ +
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2351
Query: 342 KLKASCQESAR-----IEDMRKRHVEVS 364
++ E + +E R+R +E+S
Sbjct: 2352 QMAQQLAEETQGFQRTLEAERQRQLEMS 2379
Score = 68.6 bits (166), Expect = 1e-11
Identities = 86/354 (24%), Positives = 163/354 (46%), Gaps = 41/354 (11%)
Query: 31 SPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILR------ERCEELLHFQA 84
SP KP + + G+ +Q ++ + ++Q ++ R EE
Sbjct: 1298 SPAKKPKV-----QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352
Query: 85 SQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAE-DKASVK 143
QR E+ + + + A + +L K Q E+ +E++ +R Q+++ ++A+V
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVD 1410
Query: 144 AQVT--SLLGELQE----SQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSV 197
AQ S+ ELQ+ S++ ++A ++ +A E E+ R + + EA ++Q
Sbjct: 1411 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470
Query: 198 QVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQ---EYDNHIKSSV-VGSE 253
+L+ E A +RQA E +R Q+Q + Q E + +K+ E
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1530
Query: 254 RKRGMQ-LEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADF 312
++R +Q LE+L+ Q ++AE L + EV E A Q ++ +ET AQ +A+
Sbjct: 1531 KQRALQALEELRLQAEEAERRL-RQAEV-----ERARQVQVALET-----AQRSA-EAEL 1578
Query: 313 QAERQA-REKLAEKKELLQEQ---LEQLQREYSKLKASCQESARIEDMRKRHVE 362
Q++R + EK A+ + LQE+ + QL+ E + E+ R + +R +E
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Score = 67.4 bits (163), Expect = 2e-11
Identities = 65/305 (21%), Positives = 141/305 (46%), Gaps = 32/305 (10%)
Query: 56 EENQELRDAIRQSNQILRER--CEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLD 113
E +EL ++N+ LR R EE+ ++ + E E + +EA + R G +
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQ 1682
Query: 114 LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGR 173
RQ+E A +E+E ++ + A+ + + + ++ L E ++ + + + +E L+
Sbjct: 1683 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Query: 174 ARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVA 233
A AA+++ ++LE+E ++ + V + + +A E ++ SE+ ++ + +
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLL--------ASKARAEEESRSTSEKSKQRLEAEAG 1794
Query: 234 YHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKI 293
+ E +++ ++R+R + ED +Q +AE L K I +
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR------- 1847
Query: 294 VMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARI 353
LK +A+I + +AE + +LAE + + +LE+ ++ KA +E R+
Sbjct: 1848 -------LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH---KADIEE--RL 1895
Query: 354 EDMRK 358
+RK
Sbjct: 1896 AQLRK 1900
Score = 62.0 bits (149), Expect = 1e-09
Identities = 87/356 (24%), Positives = 165/356 (46%), Gaps = 48/356 (13%)
Query: 51 LQRCLEENQELRDAIRQSN-QILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL 109
++ LE+ ++L +A Q+ Q RE E Q +E + Q+ R + E L
Sbjct: 1365 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1424
Query: 110 EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLL-------GELQESQSRLE- 161
+ + + + R+ E +R + ++ E+ V+ Q+ + GELQ ++R E
Sbjct: 1425 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1484
Query: 162 ------AATKECQALEGRARAASEQARQLESE---------REALQQQHSVQ-VDQLRMQ 205
A +E + L + + S++ RQ E E A ++Q ++Q +++LR+Q
Sbjct: 1485 AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1544
Query: 206 GQSVEAALR---MER----QAASEEKRKLAQLQV-AYHQLFQEYDNHIKSSVVGSERKRG 257
+ E LR +ER Q A E ++ A+ ++ + F E ++ S+
Sbjct: 1545 AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1604
Query: 258 MQLEDLKQQLQQAEEALVAKQEVIDKLK------EEAEQHKIVMETVPVLK--AQADIYK 309
E+ +++ QQ EA A++E +L+ EA + ++ E V K AQA+ K
Sbjct: 1605 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1664
Query: 310 ADFQAERQAR------EKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKR 359
+AER+AR E+ ++EL +++LE+ QR+ ++ A + +A E +R R
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQELIRLR 1719
Score = 50.4 bits (119), Expect = 3e-06
Identities = 93/390 (23%), Positives = 157/390 (40%), Gaps = 70/390 (17%)
Query: 3 RHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELR 62
R L + +L + + + + L E + M L + + E R E + R
Sbjct: 1729 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788
Query: 63 DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEA---RKLVERLGLEKLD------ 113
+ RE EE +A E K ++A R ER+ EKL
Sbjct: 1789 --LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 114 -LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEG 172
LK + E AL+E E +++AED+A + + L+E ++ +A +E A
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRR-------LEEQAAQHKADIEERLA--- 1896
Query: 173 RARAASEQARQLESER------EALQQQHSVQVDQLRMQGQSVEAA-------------- 212
+ R AS+ E ER + L+Q+ V+ + L ++ +AA
Sbjct: 1897 QLRKASDS----ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1952
Query: 213 ------LRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSE---RKRGMQLEDL 263
LR + QA E R+ QL + +E + ++ S+ E R+R LE++
Sbjct: 1953 SNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 264 KQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLA 323
E L AK E +L+E AEQ E+ L+ + + QAE +A
Sbjct: 2012 --------ERLKAKVEEARRLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAV 2058
Query: 324 EKKEL-LQEQLEQLQREYSKLKASCQESAR 352
++KE LQ+ L+Q Q +L+ + + R
Sbjct: 2059 QQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088
Score = 43.9 bits (102), Expect = 3e-04
Identities = 57/268 (21%), Positives = 116/268 (43%), Gaps = 16/268 (5%)
Query: 87 REEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQV 146
R E E + K ++ R L + LEKL + + E + R ++ ++ +V A
Sbjct: 1064 RSELELTLGKLEQVRSL-SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT- 1121
Query: 147 TSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQH---SVQVDQLR 203
L EL+ +++ L+ + +A + A ++ R + E LQQ+H V+V++ R
Sbjct: 1122 ---LPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1178
Query: 204 MQ-GQSVE--AALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL 260
+ Q +E A+ + E +L + Y + ++ + E+ + M L
Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1238
Query: 261 ED---LKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQ--AE 315
D +++QL+Q + L + +K++E K + + + Q YKA + A
Sbjct: 1239 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1298
Query: 316 RQAREKLAEKKELLQEQLEQLQREYSKL 343
+ K+ E + ++ L+ YS+L
Sbjct: 1299 PAKKPKVQSGSESVIQEYVDLRTHYSEL 1326
Score = 34.3 bits (77), Expect = 0.22
Identities = 51/252 (20%), Positives = 113/252 (44%), Gaps = 31/252 (12%)
Query: 38 MLHLPSEQGAPETLQRCLEENQEL-------RDAIRQSNQILRE---RCEELLHFQASQ- 86
+L L SE+ ++ L+E Q L +D++ Q + + + + E+L + ++
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527
Query: 87 ---REEKEFLMCKF-QEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASV 142
REE++ + QE ++LV + + +E R+ E L++ +QQ + + +
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2587
Query: 143 KAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREAL-------QQQH 195
+ L +LQ + + AA + + AA+ + L + R+AL + +H
Sbjct: 2588 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT---KTLPNGRDALDGPAAEAEPEH 2644
Query: 196 SVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 255
S + ++ Q ++ A + ++EE ++LAQ +L + D ++ + G
Sbjct: 2645 SFDGLRRKVSAQRLQEAGIL----SAEELQRLAQGHTTVDELARRED--VRHYLQGRSSI 2698
Query: 256 RGMQLEDLKQQL 267
G+ L+ ++L
Sbjct: 2699 AGLLLKATNEKL 2710
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 82.8 bits (203), Expect = 5e-16
Identities = 93/338 (27%), Positives = 155/338 (45%), Gaps = 38/338 (11%)
Query: 45 QGAPETLQRCLEENQELR-DAIRQSNQILR-----ERCEELLHFQASQREEKEFLMCKFQ 98
+G E +R EE +E R A R++ Q R ER ++ QA R + + K +
Sbjct: 2084 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2143
Query: 99 -EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQ 157
EA + R + RQK+ A E+E K+ +Q KA V+ ++T+L +L+E+
Sbjct: 2144 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2203
Query: 158 SRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMER 217
+ +E Q L+ A A+ Q Q+E E +++ VQ+++L +EA R
Sbjct: 2204 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEELSKLKARIEAENRALI 2259
Query: 218 QAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL--EDLKQQLQQAEEALV 275
+ ++ LQ ++ Q + + SV E R QL EDL QQ AE+ L
Sbjct: 2260 LRDKDNTQRF--LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2317
Query: 276 AKQEVID---KLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQ 332
K + + +LK EAE +L+ Q ++ A+ QAR +K+++ Q+
Sbjct: 2318 EKMQAVQEATRLKAEAE----------LLQQQKEL------AQEQARRLQEDKEQMAQQL 2361
Query: 333 LEQLQREYSKLKASCQE----SARIEDMRKRHVEVSQA 366
E+ Q L+A Q SA E ++ R E+S+A
Sbjct: 2362 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2399
Score = 77.8 bits (190), Expect = 2e-14
Identities = 82/322 (25%), Positives = 152/322 (47%), Gaps = 49/322 (15%)
Query: 56 EENQELRDAIR-QSNQILRERCEELLHFQASQ-REEKEFLMCKFQEA----RKLVERLGL 109
E+ Q +++A R ++ L ++ +EL QA + +E+KE + + E ++ +E
Sbjct: 2318 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377
Query: 110 EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKE--- 166
+L++ + E+ V + R Q + ED + Q E+ E R E AT+E
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEKVT 2433
Query: 167 -CQALEGRARAASEQAR-------QLESEREALQQQ-----------HSVQVDQLRMQGQ 207
Q LE + + + A +LE E+E LQQ+ +VQ +QL + Q
Sbjct: 2434 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2493
Query: 208 SVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQL 267
+++ + E+ + + +R + Q + QLFQ D K+ + E++R +QQ+
Sbjct: 2494 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ--DEVAKAQQLREEQQRQ------QQQM 2545
Query: 268 QQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKE 327
+Q + LVA E + + EAE+ V + Q ++ + + Q RQ E LAE+ +
Sbjct: 2546 EQERQRLVASMEEARRRQHEAEEG--------VRRKQEELQQLE-QQRRQQEELLAEENQ 2596
Query: 328 LLQEQLEQLQREYSKLKASCQE 349
L+EQL+ L+ ++ A +E
Sbjct: 2597 RLREQLQLLEEQHRAALAHSEE 2618
Score = 74.7 bits (182), Expect = 1e-13
Identities = 88/360 (24%), Positives = 154/360 (42%), Gaps = 62/360 (17%)
Query: 27 LGEESPLGKPAMLHLPSEQGAPETLQRCLEEN----QELRDAIRQSNQILRERCEELLHF 82
+GE + L A + L ++ E L+R E+ + L + Q + ER +L
Sbjct: 1846 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1905
Query: 83 QASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASV 142
S+ E + + LVE D RQ+ Q E+ LK ++ A KA +
Sbjct: 1906 SDSELERQ----------KGLVE-------DTLRQRRQVEEEILALKASFEKAAAGKAEL 1948
Query: 143 KAQVTSLLGELQES-----QSRLEAATKECQALEG--RARAASEQARQLESEREALQQQH 195
+ ++ + +++ Q+ LEAA + A E R R A E+ ++ + E +Q
Sbjct: 1949 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 2008
Query: 196 SVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 255
++++ VE A R+ +A E R+L Q A + Q E+
Sbjct: 2009 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ-----------AEEKA 2057
Query: 256 RGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAE 315
++ +Q+LQQ L +Q V+D+L+ EAE + +A + +A QAE
Sbjct: 2058 HAFAVQQKEQELQQT---LQQEQSVLDQLRGEAEAAR---------RAAEEAEEARVQAE 2105
Query: 316 RQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRK-------RHVEVSQAPL 368
R+A + + +E E+L+Q E ++ +A Q +A E +RK R + QA L
Sbjct: 2106 REAAQSRRQVEE--AERLKQSAEEQAQARAQAQAAA--EKLRKEAEQEAARRAQAEQAAL 2161
Score = 74.3 bits (181), Expect = 2e-13
Identities = 96/388 (24%), Positives = 164/388 (42%), Gaps = 66/388 (17%)
Query: 41 LPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEE------LLHFQASQR----EEK 90
L +E+ A + LEE + L+ + ++ + LRER E+ L +A+Q+ EEK
Sbjct: 1998 LAAEEEAARQRKAALEEVERLKAKVEEARR-LRERAEQESARQLQLAQEAAQKRLQAEEK 2056
Query: 91 EFLMCKFQEARKLVERLGLEK--LD-LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVT 147
Q+ ++L + L E+ LD L+ + E A R E + + Q + A + QV
Sbjct: 2057 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2116
Query: 148 SLLGELQESQSRLEAATKECQALEG-RARAASEQARQLESEREALQQQHSVQVDQLRMQG 206
Q ++ + +A + A E R A E AR+ ++E+ AL+Q+ + + +
Sbjct: 2117 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE-MEKHK 2175
Query: 207 QSVEAALRMERQAASEEKRKLAQLQVAYHQ--LFQEYDNHIKSSVVGSERKRGM------ 258
+ E LR + Q E QL+ HQ L E +K+ + R+R
Sbjct: 2176 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2235
Query: 259 -------QLEDLKQQLQQAEEALVA--KQEVIDKLKEEAEQHKIVMETVPVLK------- 302
+L LK +++ AL+ K L+EEAE+ K V E L
Sbjct: 2236 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2295
Query: 303 -----AQADIYKADFQAERQAREK----------------LAEKKELLQEQLEQLQREYS 341
A+ D+ + AE+ +EK L ++KEL QEQ +LQ +
Sbjct: 2296 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2355
Query: 342 KLKASCQESAR-----IEDMRKRHVEVS 364
++ E + +E R+R +E+S
Sbjct: 2356 QMAQQLAEETQGFQRTLEAERQRQLEMS 2383
Score = 68.6 bits (166), Expect = 1e-11
Identities = 86/354 (24%), Positives = 163/354 (46%), Gaps = 41/354 (11%)
Query: 31 SPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILR------ERCEELLHFQA 84
SP KP + + G+ +Q ++ + ++Q ++ R EE
Sbjct: 1302 SPAKKPKV-----QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1356
Query: 85 SQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAE-DKASVK 143
QR E+ + + + A + +L K Q E+ +E++ +R Q+++ ++A+V
Sbjct: 1357 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVD 1414
Query: 144 AQVT--SLLGELQE----SQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSV 197
AQ S+ ELQ+ S++ ++A ++ +A E E+ R + + EA ++Q
Sbjct: 1415 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1474
Query: 198 QVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQ---EYDNHIKSSV-VGSE 253
+L+ E A +RQA E +R Q+Q + Q E + +K+ E
Sbjct: 1475 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1534
Query: 254 RKRGMQ-LEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADF 312
++R +Q LE+L+ Q ++AE L + EV E A Q ++ +ET AQ +A+
Sbjct: 1535 KQRALQALEELRLQAEEAERRL-RQAEV-----ERARQVQVALET-----AQRSA-EAEL 1582
Query: 313 QAERQA-REKLAEKKELLQEQ---LEQLQREYSKLKASCQESARIEDMRKRHVE 362
Q++R + EK A+ + LQE+ + QL+ E + E+ R + +R +E
Sbjct: 1583 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636
Score = 67.4 bits (163), Expect = 2e-11
Identities = 65/305 (21%), Positives = 141/305 (46%), Gaps = 32/305 (10%)
Query: 56 EENQELRDAIRQSNQILRER--CEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLD 113
E +EL ++N+ LR R EE+ ++ + E E + +EA + R G +
Sbjct: 1630 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQ 1686
Query: 114 LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGR 173
RQ+E A +E+E ++ + A+ + + + ++ L E ++ + + + +E L+
Sbjct: 1687 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1746
Query: 174 ARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVA 233
A AA+++ ++LE+E ++ + V + + +A E ++ SE+ ++ + +
Sbjct: 1747 AAAATQKRQELEAELAKVRAEMEVLL--------ASKARAEEESRSTSEKSKQRLEAEAG 1798
Query: 234 YHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKI 293
+ E +++ ++R+R + ED +Q +AE L K I +
Sbjct: 1799 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR------- 1851
Query: 294 VMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARI 353
LK +A+I + +AE + +LAE + + +LE+ ++ KA +E R+
Sbjct: 1852 -------LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH---KADIEE--RL 1899
Query: 354 EDMRK 358
+RK
Sbjct: 1900 AQLRK 1904
Score = 62.0 bits (149), Expect = 1e-09
Identities = 87/356 (24%), Positives = 165/356 (46%), Gaps = 48/356 (13%)
Query: 51 LQRCLEENQELRDAIRQSN-QILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL 109
++ LE+ ++L +A Q+ Q RE E Q +E + Q+ R + E L
Sbjct: 1369 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1428
Query: 110 EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLL-------GELQESQSRLE- 161
+ + + + R+ E +R + ++ E+ V+ Q+ + GELQ ++R E
Sbjct: 1429 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1488
Query: 162 ------AATKECQALEGRARAASEQARQLESE---------REALQQQHSVQ-VDQLRMQ 205
A +E + L + + S++ RQ E E A ++Q ++Q +++LR+Q
Sbjct: 1489 AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1548
Query: 206 GQSVEAALR---MER----QAASEEKRKLAQLQV-AYHQLFQEYDNHIKSSVVGSERKRG 257
+ E LR +ER Q A E ++ A+ ++ + F E ++ S+
Sbjct: 1549 AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1608
Query: 258 MQLEDLKQQLQQAEEALVAKQEVIDKLK------EEAEQHKIVMETVPVLK--AQADIYK 309
E+ +++ QQ EA A++E +L+ EA + ++ E V K AQA+ K
Sbjct: 1609 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1668
Query: 310 ADFQAERQAR------EKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKR 359
+AER+AR E+ ++EL +++LE+ QR+ ++ A + +A E +R R
Sbjct: 1669 QKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQELIRLR 1723
Score = 50.4 bits (119), Expect = 3e-06
Identities = 93/390 (23%), Positives = 157/390 (40%), Gaps = 70/390 (17%)
Query: 3 RHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELR 62
R L + +L + + + + L E + M L + + E R E + R
Sbjct: 1733 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1792
Query: 63 DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEA---RKLVERLGLEKLD------ 113
+ RE EE +A E K ++A R ER+ EKL
Sbjct: 1793 --LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1850
Query: 114 -LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEG 172
LK + E AL+E E +++AED+A + + L+E ++ +A +E A
Sbjct: 1851 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRR-------LEEQAAQHKADIEERLA--- 1900
Query: 173 RARAASEQARQLESER------EALQQQHSVQVDQLRMQGQSVEAA-------------- 212
+ R AS+ E ER + L+Q+ V+ + L ++ +AA
Sbjct: 1901 QLRKASDS----ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1956
Query: 213 ------LRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSE---RKRGMQLEDL 263
LR + QA E R+ QL + +E + ++ S+ E R+R LE++
Sbjct: 1957 SNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2015
Query: 264 KQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLA 323
E L AK E +L+E AEQ E+ L+ + + QAE +A
Sbjct: 2016 --------ERLKAKVEEARRLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAV 2062
Query: 324 EKKEL-LQEQLEQLQREYSKLKASCQESAR 352
++KE LQ+ L+Q Q +L+ + + R
Sbjct: 2063 QQKEQELQQTLQQEQSVLDQLRGEAEAARR 2092
Score = 43.9 bits (102), Expect = 3e-04
Identities = 57/268 (21%), Positives = 116/268 (43%), Gaps = 16/268 (5%)
Query: 87 REEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQV 146
R E E + K ++ R L + LEKL + + E + R ++ ++ +V A
Sbjct: 1068 RSELELTLGKLEQVRSL-SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT- 1125
Query: 147 TSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQH---SVQVDQLR 203
L EL+ +++ L+ + +A + A ++ R + E LQQ+H V+V++ R
Sbjct: 1126 ---LPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1182
Query: 204 MQ-GQSVE--AALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL 260
+ Q +E A+ + E +L + Y + ++ + E+ + M L
Sbjct: 1183 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1242
Query: 261 ED---LKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQ--AE 315
D +++QL+Q + L + +K++E K + + + Q YKA + A
Sbjct: 1243 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1302
Query: 316 RQAREKLAEKKELLQEQLEQLQREYSKL 343
+ K+ E + ++ L+ YS+L
Sbjct: 1303 PAKKPKVQSGSESVIQEYVDLRTHYSEL 1330
Score = 34.3 bits (77), Expect = 0.22
Identities = 51/252 (20%), Positives = 113/252 (44%), Gaps = 31/252 (12%)
Query: 38 MLHLPSEQGAPETLQRCLEENQEL-------RDAIRQSNQILRE---RCEELLHFQASQ- 86
+L L SE+ ++ L+E Q L +D++ Q + + + + E+L + ++
Sbjct: 2472 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2531
Query: 87 ---REEKEFLMCKF-QEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASV 142
REE++ + QE ++LV + + +E R+ E L++ +QQ + + +
Sbjct: 2532 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2591
Query: 143 KAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREAL-------QQQH 195
+ L +LQ + + AA + + AA+ + L + R+AL + +H
Sbjct: 2592 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT---KTLPNGRDALDGPAAEAEPEH 2648
Query: 196 SVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 255
S + ++ Q ++ A + ++EE ++LAQ +L + D ++ + G
Sbjct: 2649 SFDGLRRKVSAQRLQEAGIL----SAEELQRLAQGHTTVDELARRED--VRHYLQGRSSI 2702
Query: 256 RGMQLEDLKQQL 267
G+ L+ ++L
Sbjct: 2703 AGLLLKATNEKL 2714
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 82.8 bits (203), Expect = 5e-16
Identities = 93/338 (27%), Positives = 155/338 (45%), Gaps = 38/338 (11%)
Query: 45 QGAPETLQRCLEENQELR-DAIRQSNQILR-----ERCEELLHFQASQREEKEFLMCKFQ 98
+G E +R EE +E R A R++ Q R ER ++ QA R + + K +
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 99 -EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQ 157
EA + R + RQK+ A E+E K+ +Q KA V+ ++T+L +L+E+
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 158 SRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMER 217
+ +E Q L+ A A+ Q Q+E E +++ VQ+++L +EA R
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEELSKLKARIEAENRALI 2255
Query: 218 QAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL--EDLKQQLQQAEEALV 275
+ ++ LQ ++ Q + + SV E R QL EDL QQ AE+ L
Sbjct: 2256 LRDKDNTQRF--LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2313
Query: 276 AKQEVID---KLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQ 332
K + + +LK EAE +L+ Q ++ A+ QAR +K+++ Q+
Sbjct: 2314 EKMQAVQEATRLKAEAE----------LLQQQKEL------AQEQARRLQEDKEQMAQQL 2357
Query: 333 LEQLQREYSKLKASCQE----SARIEDMRKRHVEVSQA 366
E+ Q L+A Q SA E ++ R E+S+A
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2395
Score = 77.8 bits (190), Expect = 2e-14
Identities = 82/322 (25%), Positives = 152/322 (47%), Gaps = 49/322 (15%)
Query: 56 EENQELRDAIR-QSNQILRERCEELLHFQASQ-REEKEFLMCKFQEA----RKLVERLGL 109
E+ Q +++A R ++ L ++ +EL QA + +E+KE + + E ++ +E
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 110 EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKE--- 166
+L++ + E+ V + R Q + ED + Q E+ E R E AT+E
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEKVT 2429
Query: 167 -CQALEGRARAASEQAR-------QLESEREALQQQ-----------HSVQVDQLRMQGQ 207
Q LE + + + A +LE E+E LQQ+ +VQ +QL + Q
Sbjct: 2430 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2489
Query: 208 SVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQL 267
+++ + E+ + + +R + Q + QLFQ D K+ + E++R +QQ+
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ--DEVAKAQQLREEQQRQ------QQQM 2541
Query: 268 QQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKE 327
+Q + LVA E + + EAE+ V + Q ++ + + Q RQ E LAE+ +
Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEG--------VRRKQEELQQLE-QQRRQQEELLAEENQ 2592
Query: 328 LLQEQLEQLQREYSKLKASCQE 349
L+EQL+ L+ ++ A +E
Sbjct: 2593 RLREQLQLLEEQHRAALAHSEE 2614
Score = 74.7 bits (182), Expect = 1e-13
Identities = 88/360 (24%), Positives = 154/360 (42%), Gaps = 62/360 (17%)
Query: 27 LGEESPLGKPAMLHLPSEQGAPETLQRCLEEN----QELRDAIRQSNQILRERCEELLHF 82
+GE + L A + L ++ E L+R E+ + L + Q + ER +L
Sbjct: 1842 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901
Query: 83 QASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASV 142
S+ E + + LVE D RQ+ Q E+ LK ++ A KA +
Sbjct: 1902 SDSELERQ----------KGLVE-------DTLRQRRQVEEEILALKASFEKAAAGKAEL 1944
Query: 143 KAQVTSLLGELQES-----QSRLEAATKECQALEG--RARAASEQARQLESEREALQQQH 195
+ ++ + +++ Q+ LEAA + A E R R A E+ ++ + E +Q
Sbjct: 1945 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 2004
Query: 196 SVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 255
++++ VE A R+ +A E R+L Q A + Q E+
Sbjct: 2005 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ-----------AEEKA 2053
Query: 256 RGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAE 315
++ +Q+LQQ L +Q V+D+L+ EAE + +A + +A QAE
Sbjct: 2054 HAFAVQQKEQELQQT---LQQEQSVLDQLRGEAEAAR---------RAAEEAEEARVQAE 2101
Query: 316 RQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRK-------RHVEVSQAPL 368
R+A + + +E E+L+Q E ++ +A Q +A E +RK R + QA L
Sbjct: 2102 REAAQSRRQVEE--AERLKQSAEEQAQARAQAQAAA--EKLRKEAEQEAARRAQAEQAAL 2157
Score = 74.3 bits (181), Expect = 2e-13
Identities = 96/388 (24%), Positives = 164/388 (42%), Gaps = 66/388 (17%)
Query: 41 LPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEE------LLHFQASQR----EEK 90
L +E+ A + LEE + L+ + ++ + LRER E+ L +A+Q+ EEK
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARR-LRERAEQESARQLQLAQEAAQKRLQAEEK 2052
Query: 91 EFLMCKFQEARKLVERLGLEK--LD-LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVT 147
Q+ ++L + L E+ LD L+ + E A R E + + Q + A + QV
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2112
Query: 148 SLLGELQESQSRLEAATKECQALEG-RARAASEQARQLESEREALQQQHSVQVDQLRMQG 206
Q ++ + +A + A E R A E AR+ ++E+ AL+Q+ + + +
Sbjct: 2113 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE-MEKHK 2171
Query: 207 QSVEAALRMERQAASEEKRKLAQLQVAYHQ--LFQEYDNHIKSSVVGSERKRGM------ 258
+ E LR + Q E QL+ HQ L E +K+ + R+R
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2231
Query: 259 -------QLEDLKQQLQQAEEALVA--KQEVIDKLKEEAEQHKIVMETVPVLK------- 302
+L LK +++ AL+ K L+EEAE+ K V E L
Sbjct: 2232 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2291
Query: 303 -----AQADIYKADFQAERQAREK----------------LAEKKELLQEQLEQLQREYS 341
A+ D+ + AE+ +EK L ++KEL QEQ +LQ +
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2351
Query: 342 KLKASCQESAR-----IEDMRKRHVEVS 364
++ E + +E R+R +E+S
Sbjct: 2352 QMAQQLAEETQGFQRTLEAERQRQLEMS 2379
Score = 68.6 bits (166), Expect = 1e-11
Identities = 86/354 (24%), Positives = 163/354 (46%), Gaps = 41/354 (11%)
Query: 31 SPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILR------ERCEELLHFQA 84
SP KP + + G+ +Q ++ + ++Q ++ R EE
Sbjct: 1298 SPAKKPKV-----QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352
Query: 85 SQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAE-DKASVK 143
QR E+ + + + A + +L K Q E+ +E++ +R Q+++ ++A+V
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVD 1410
Query: 144 AQVT--SLLGELQE----SQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSV 197
AQ S+ ELQ+ S++ ++A ++ +A E E+ R + + EA ++Q
Sbjct: 1411 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470
Query: 198 QVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQ---EYDNHIKSSV-VGSE 253
+L+ E A +RQA E +R Q+Q + Q E + +K+ E
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1530
Query: 254 RKRGMQ-LEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADF 312
++R +Q LE+L+ Q ++AE L + EV E A Q ++ +ET AQ +A+
Sbjct: 1531 KQRALQALEELRLQAEEAERRL-RQAEV-----ERARQVQVALET-----AQRSA-EAEL 1578
Query: 313 QAERQA-REKLAEKKELLQEQ---LEQLQREYSKLKASCQESARIEDMRKRHVE 362
Q++R + EK A+ + LQE+ + QL+ E + E+ R + +R +E
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Score = 67.4 bits (163), Expect = 2e-11
Identities = 65/305 (21%), Positives = 141/305 (46%), Gaps = 32/305 (10%)
Query: 56 EENQELRDAIRQSNQILRER--CEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLD 113
E +EL ++N+ LR R EE+ ++ + E E + +EA + R G +
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQ 1682
Query: 114 LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGR 173
RQ+E A +E+E ++ + A+ + + + ++ L E ++ + + + +E L+
Sbjct: 1683 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Query: 174 ARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVA 233
A AA+++ ++LE+E ++ + V + + +A E ++ SE+ ++ + +
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLL--------ASKARAEEESRSTSEKSKQRLEAEAG 1794
Query: 234 YHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKI 293
+ E +++ ++R+R + ED +Q +AE L K I +
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR------- 1847
Query: 294 VMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARI 353
LK +A+I + +AE + +LAE + + +LE+ ++ KA +E R+
Sbjct: 1848 -------LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH---KADIEE--RL 1895
Query: 354 EDMRK 358
+RK
Sbjct: 1896 AQLRK 1900
Score = 62.0 bits (149), Expect = 1e-09
Identities = 87/356 (24%), Positives = 165/356 (46%), Gaps = 48/356 (13%)
Query: 51 LQRCLEENQELRDAIRQSN-QILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL 109
++ LE+ ++L +A Q+ Q RE E Q +E + Q+ R + E L
Sbjct: 1365 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1424
Query: 110 EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLL-------GELQESQSRLE- 161
+ + + + R+ E +R + ++ E+ V+ Q+ + GELQ ++R E
Sbjct: 1425 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1484
Query: 162 ------AATKECQALEGRARAASEQARQLESE---------REALQQQHSVQ-VDQLRMQ 205
A +E + L + + S++ RQ E E A ++Q ++Q +++LR+Q
Sbjct: 1485 AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1544
Query: 206 GQSVEAALR---MER----QAASEEKRKLAQLQV-AYHQLFQEYDNHIKSSVVGSERKRG 257
+ E LR +ER Q A E ++ A+ ++ + F E ++ S+
Sbjct: 1545 AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1604
Query: 258 MQLEDLKQQLQQAEEALVAKQEVIDKLK------EEAEQHKIVMETVPVLK--AQADIYK 309
E+ +++ QQ EA A++E +L+ EA + ++ E V K AQA+ K
Sbjct: 1605 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1664
Query: 310 ADFQAERQAR------EKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKR 359
+AER+AR E+ ++EL +++LE+ QR+ ++ A + +A E +R R
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQELIRLR 1719
Score = 50.4 bits (119), Expect = 3e-06
Identities = 93/390 (23%), Positives = 157/390 (40%), Gaps = 70/390 (17%)
Query: 3 RHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELR 62
R L + +L + + + + L E + M L + + E R E + R
Sbjct: 1729 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788
Query: 63 DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEA---RKLVERLGLEKLD------ 113
+ RE EE +A E K ++A R ER+ EKL
Sbjct: 1789 --LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 114 -LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEG 172
LK + E AL+E E +++AED+A + + L+E ++ +A +E A
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRR-------LEEQAAQHKADIEERLA--- 1896
Query: 173 RARAASEQARQLESER------EALQQQHSVQVDQLRMQGQSVEAA-------------- 212
+ R AS+ E ER + L+Q+ V+ + L ++ +AA
Sbjct: 1897 QLRKASDS----ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1952
Query: 213 ------LRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSE---RKRGMQLEDL 263
LR + QA E R+ QL + +E + ++ S+ E R+R LE++
Sbjct: 1953 SNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 264 KQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLA 323
E L AK E +L+E AEQ E+ L+ + + QAE +A
Sbjct: 2012 --------ERLKAKVEEARRLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAV 2058
Query: 324 EKKEL-LQEQLEQLQREYSKLKASCQESAR 352
++KE LQ+ L+Q Q +L+ + + R
Sbjct: 2059 QQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088
Score = 43.9 bits (102), Expect = 3e-04
Identities = 57/268 (21%), Positives = 116/268 (43%), Gaps = 16/268 (5%)
Query: 87 REEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQV 146
R E E + K ++ R L + LEKL + + E + R ++ ++ +V A
Sbjct: 1064 RSELELTLGKLEQVRSL-SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT- 1121
Query: 147 TSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQH---SVQVDQLR 203
L EL+ +++ L+ + +A + A ++ R + E LQQ+H V+V++ R
Sbjct: 1122 ---LPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1178
Query: 204 MQ-GQSVE--AALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL 260
+ Q +E A+ + E +L + Y + ++ + E+ + M L
Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1238
Query: 261 ED---LKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQ--AE 315
D +++QL+Q + L + +K++E K + + + Q YKA + A
Sbjct: 1239 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1298
Query: 316 RQAREKLAEKKELLQEQLEQLQREYSKL 343
+ K+ E + ++ L+ YS+L
Sbjct: 1299 PAKKPKVQSGSESVIQEYVDLRTHYSEL 1326
Score = 34.3 bits (77), Expect = 0.22
Identities = 51/252 (20%), Positives = 113/252 (44%), Gaps = 31/252 (12%)
Query: 38 MLHLPSEQGAPETLQRCLEENQEL-------RDAIRQSNQILRE---RCEELLHFQASQ- 86
+L L SE+ ++ L+E Q L +D++ Q + + + + E+L + ++
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527
Query: 87 ---REEKEFLMCKF-QEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASV 142
REE++ + QE ++LV + + +E R+ E L++ +QQ + + +
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2587
Query: 143 KAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREAL-------QQQH 195
+ L +LQ + + AA + + AA+ + L + R+AL + +H
Sbjct: 2588 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT---KTLPNGRDALDGPAAEAEPEH 2644
Query: 196 SVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 255
S + ++ Q ++ A + ++EE ++LAQ +L + D ++ + G
Sbjct: 2645 SFDGLRRKVSAQRLQEAGIL----SAEELQRLAQGHTTVDELARRED--VRHYLQGRSSI 2698
Query: 256 RGMQLEDLKQQL 267
G+ L+ ++L
Sbjct: 2699 AGLLLKATNEKL 2710
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 82.8 bits (203), Expect = 5e-16
Identities = 93/338 (27%), Positives = 155/338 (45%), Gaps = 38/338 (11%)
Query: 45 QGAPETLQRCLEENQELR-DAIRQSNQILR-----ERCEELLHFQASQREEKEFLMCKFQ 98
+G E +R EE +E R A R++ Q R ER ++ QA R + + K +
Sbjct: 2048 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2107
Query: 99 -EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQ 157
EA + R + RQK+ A E+E K+ +Q KA V+ ++T+L +L+E+
Sbjct: 2108 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2167
Query: 158 SRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMER 217
+ +E Q L+ A A+ Q Q+E E +++ VQ+++L +EA R
Sbjct: 2168 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEELSKLKARIEAENRALI 2223
Query: 218 QAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL--EDLKQQLQQAEEALV 275
+ ++ LQ ++ Q + + SV E R QL EDL QQ AE+ L
Sbjct: 2224 LRDKDNTQRF--LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2281
Query: 276 AKQEVID---KLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQ 332
K + + +LK EAE +L+ Q ++ A+ QAR +K+++ Q+
Sbjct: 2282 EKMQAVQEATRLKAEAE----------LLQQQKEL------AQEQARRLQEDKEQMAQQL 2325
Query: 333 LEQLQREYSKLKASCQE----SARIEDMRKRHVEVSQA 366
E+ Q L+A Q SA E ++ R E+S+A
Sbjct: 2326 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2363
Score = 77.8 bits (190), Expect = 2e-14
Identities = 82/322 (25%), Positives = 152/322 (47%), Gaps = 49/322 (15%)
Query: 56 EENQELRDAIR-QSNQILRERCEELLHFQASQ-REEKEFLMCKFQEA----RKLVERLGL 109
E+ Q +++A R ++ L ++ +EL QA + +E+KE + + E ++ +E
Sbjct: 2282 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341
Query: 110 EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKE--- 166
+L++ + E+ V + R Q + ED + Q E+ E R E AT+E
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEKVT 2397
Query: 167 -CQALEGRARAASEQAR-------QLESEREALQQQ-----------HSVQVDQLRMQGQ 207
Q LE + + + A +LE E+E LQQ+ +VQ +QL + Q
Sbjct: 2398 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2457
Query: 208 SVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQL 267
+++ + E+ + + +R + Q + QLFQ D K+ + E++R +QQ+
Sbjct: 2458 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ--DEVAKAQQLREEQQRQ------QQQM 2509
Query: 268 QQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKE 327
+Q + LVA E + + EAE+ V + Q ++ + + Q RQ E LAE+ +
Sbjct: 2510 EQERQRLVASMEEARRRQHEAEEG--------VRRKQEELQQLE-QQRRQQEELLAEENQ 2560
Query: 328 LLQEQLEQLQREYSKLKASCQE 349
L+EQL+ L+ ++ A +E
Sbjct: 2561 RLREQLQLLEEQHRAALAHSEE 2582
Score = 74.7 bits (182), Expect = 1e-13
Identities = 88/360 (24%), Positives = 154/360 (42%), Gaps = 62/360 (17%)
Query: 27 LGEESPLGKPAMLHLPSEQGAPETLQRCLEEN----QELRDAIRQSNQILRERCEELLHF 82
+GE + L A + L ++ E L+R E+ + L + Q + ER +L
Sbjct: 1810 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1869
Query: 83 QASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASV 142
S+ E + + LVE D RQ+ Q E+ LK ++ A KA +
Sbjct: 1870 SDSELERQ----------KGLVE-------DTLRQRRQVEEEILALKASFEKAAAGKAEL 1912
Query: 143 KAQVTSLLGELQES-----QSRLEAATKECQALEG--RARAASEQARQLESEREALQQQH 195
+ ++ + +++ Q+ LEAA + A E R R A E+ ++ + E +Q
Sbjct: 1913 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 1972
Query: 196 SVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 255
++++ VE A R+ +A E R+L Q A + Q E+
Sbjct: 1973 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ-----------AEEKA 2021
Query: 256 RGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAE 315
++ +Q+LQQ L +Q V+D+L+ EAE + +A + +A QAE
Sbjct: 2022 HAFAVQQKEQELQQT---LQQEQSVLDQLRGEAEAAR---------RAAEEAEEARVQAE 2069
Query: 316 RQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRK-------RHVEVSQAPL 368
R+A + + +E E+L+Q E ++ +A Q +A E +RK R + QA L
Sbjct: 2070 REAAQSRRQVEE--AERLKQSAEEQAQARAQAQAAA--EKLRKEAEQEAARRAQAEQAAL 2125
Score = 74.3 bits (181), Expect = 2e-13
Identities = 96/388 (24%), Positives = 164/388 (42%), Gaps = 66/388 (17%)
Query: 41 LPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEE------LLHFQASQR----EEK 90
L +E+ A + LEE + L+ + ++ + LRER E+ L +A+Q+ EEK
Sbjct: 1962 LAAEEEAARQRKAALEEVERLKAKVEEARR-LRERAEQESARQLQLAQEAAQKRLQAEEK 2020
Query: 91 EFLMCKFQEARKLVERLGLEK--LD-LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVT 147
Q+ ++L + L E+ LD L+ + E A R E + + Q + A + QV
Sbjct: 2021 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2080
Query: 148 SLLGELQESQSRLEAATKECQALEG-RARAASEQARQLESEREALQQQHSVQVDQLRMQG 206
Q ++ + +A + A E R A E AR+ ++E+ AL+Q+ + + +
Sbjct: 2081 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE-MEKHK 2139
Query: 207 QSVEAALRMERQAASEEKRKLAQLQVAYHQ--LFQEYDNHIKSSVVGSERKRGM------ 258
+ E LR + Q E QL+ HQ L E +K+ + R+R
Sbjct: 2140 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2199
Query: 259 -------QLEDLKQQLQQAEEALVA--KQEVIDKLKEEAEQHKIVMETVPVLK------- 302
+L LK +++ AL+ K L+EEAE+ K V E L
Sbjct: 2200 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2259
Query: 303 -----AQADIYKADFQAERQAREK----------------LAEKKELLQEQLEQLQREYS 341
A+ D+ + AE+ +EK L ++KEL QEQ +LQ +
Sbjct: 2260 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2319
Query: 342 KLKASCQESAR-----IEDMRKRHVEVS 364
++ E + +E R+R +E+S
Sbjct: 2320 QMAQQLAEETQGFQRTLEAERQRQLEMS 2347
Score = 68.6 bits (166), Expect = 1e-11
Identities = 86/354 (24%), Positives = 163/354 (46%), Gaps = 41/354 (11%)
Query: 31 SPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILR------ERCEELLHFQA 84
SP KP + + G+ +Q ++ + ++Q ++ R EE
Sbjct: 1266 SPAKKPKV-----QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1320
Query: 85 SQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAE-DKASVK 143
QR E+ + + + A + +L K Q E+ +E++ +R Q+++ ++A+V
Sbjct: 1321 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVD 1378
Query: 144 AQVT--SLLGELQE----SQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSV 197
AQ S+ ELQ+ S++ ++A ++ +A E E+ R + + EA ++Q
Sbjct: 1379 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1438
Query: 198 QVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQ---EYDNHIKSSV-VGSE 253
+L+ E A +RQA E +R Q+Q + Q E + +K+ E
Sbjct: 1439 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1498
Query: 254 RKRGMQ-LEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADF 312
++R +Q LE+L+ Q ++AE L + EV E A Q ++ +ET AQ +A+
Sbjct: 1499 KQRALQALEELRLQAEEAERRL-RQAEV-----ERARQVQVALET-----AQRSA-EAEL 1546
Query: 313 QAERQA-REKLAEKKELLQEQ---LEQLQREYSKLKASCQESARIEDMRKRHVE 362
Q++R + EK A+ + LQE+ + QL+ E + E+ R + +R +E
Sbjct: 1547 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600
Score = 67.4 bits (163), Expect = 2e-11
Identities = 65/305 (21%), Positives = 141/305 (46%), Gaps = 32/305 (10%)
Query: 56 EENQELRDAIRQSNQILRER--CEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLD 113
E +EL ++N+ LR R EE+ ++ + E E + +EA + R G +
Sbjct: 1594 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQ 1650
Query: 114 LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGR 173
RQ+E A +E+E ++ + A+ + + + ++ L E ++ + + + +E L+
Sbjct: 1651 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1710
Query: 174 ARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVA 233
A AA+++ ++LE+E ++ + V + + +A E ++ SE+ ++ + +
Sbjct: 1711 AAAATQKRQELEAELAKVRAEMEVLL--------ASKARAEEESRSTSEKSKQRLEAEAG 1762
Query: 234 YHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKI 293
+ E +++ ++R+R + ED +Q +AE L K I +
Sbjct: 1763 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR------- 1815
Query: 294 VMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARI 353
LK +A+I + +AE + +LAE + + +LE+ ++ KA +E R+
Sbjct: 1816 -------LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH---KADIEE--RL 1863
Query: 354 EDMRK 358
+RK
Sbjct: 1864 AQLRK 1868
Score = 62.0 bits (149), Expect = 1e-09
Identities = 87/356 (24%), Positives = 165/356 (46%), Gaps = 48/356 (13%)
Query: 51 LQRCLEENQELRDAIRQSN-QILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL 109
++ LE+ ++L +A Q+ Q RE E Q +E + Q+ R + E L
Sbjct: 1333 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1392
Query: 110 EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLL-------GELQESQSRLE- 161
+ + + + R+ E +R + ++ E+ V+ Q+ + GELQ ++R E
Sbjct: 1393 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1452
Query: 162 ------AATKECQALEGRARAASEQARQLESE---------REALQQQHSVQ-VDQLRMQ 205
A +E + L + + S++ RQ E E A ++Q ++Q +++LR+Q
Sbjct: 1453 AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1512
Query: 206 GQSVEAALR---MER----QAASEEKRKLAQLQV-AYHQLFQEYDNHIKSSVVGSERKRG 257
+ E LR +ER Q A E ++ A+ ++ + F E ++ S+
Sbjct: 1513 AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1572
Query: 258 MQLEDLKQQLQQAEEALVAKQEVIDKLK------EEAEQHKIVMETVPVLK--AQADIYK 309
E+ +++ QQ EA A++E +L+ EA + ++ E V K AQA+ K
Sbjct: 1573 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1632
Query: 310 ADFQAERQAR------EKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKR 359
+AER+AR E+ ++EL +++LE+ QR+ ++ A + +A E +R R
Sbjct: 1633 QKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQELIRLR 1687
Score = 50.4 bits (119), Expect = 3e-06
Identities = 93/390 (23%), Positives = 157/390 (40%), Gaps = 70/390 (17%)
Query: 3 RHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELR 62
R L + +L + + + + L E + M L + + E R E + R
Sbjct: 1697 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1756
Query: 63 DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEA---RKLVERLGLEKLD------ 113
+ RE EE +A E K ++A R ER+ EKL
Sbjct: 1757 --LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1814
Query: 114 -LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEG 172
LK + E AL+E E +++AED+A + + L+E ++ +A +E A
Sbjct: 1815 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRR-------LEEQAAQHKADIEERLA--- 1864
Query: 173 RARAASEQARQLESER------EALQQQHSVQVDQLRMQGQSVEAA-------------- 212
+ R AS+ E ER + L+Q+ V+ + L ++ +AA
Sbjct: 1865 QLRKASDS----ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1920
Query: 213 ------LRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSE---RKRGMQLEDL 263
LR + QA E R+ QL + +E + ++ S+ E R+R LE++
Sbjct: 1921 SNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1979
Query: 264 KQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLA 323
E L AK E +L+E AEQ E+ L+ + + QAE +A
Sbjct: 1980 --------ERLKAKVEEARRLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAV 2026
Query: 324 EKKEL-LQEQLEQLQREYSKLKASCQESAR 352
++KE LQ+ L+Q Q +L+ + + R
Sbjct: 2027 QQKEQELQQTLQQEQSVLDQLRGEAEAARR 2056
Score = 43.9 bits (102), Expect = 3e-04
Identities = 57/268 (21%), Positives = 116/268 (43%), Gaps = 16/268 (5%)
Query: 87 REEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQV 146
R E E + K ++ R L + LEKL + + E + R ++ ++ +V A
Sbjct: 1032 RSELELTLGKLEQVRSL-SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT- 1089
Query: 147 TSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQH---SVQVDQLR 203
L EL+ +++ L+ + +A + A ++ R + E LQQ+H V+V++ R
Sbjct: 1090 ---LPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1146
Query: 204 MQ-GQSVE--AALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL 260
+ Q +E A+ + E +L + Y + ++ + E+ + M L
Sbjct: 1147 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1206
Query: 261 ED---LKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQ--AE 315
D +++QL+Q + L + +K++E K + + + Q YKA + A
Sbjct: 1207 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1266
Query: 316 RQAREKLAEKKELLQEQLEQLQREYSKL 343
+ K+ E + ++ L+ YS+L
Sbjct: 1267 PAKKPKVQSGSESVIQEYVDLRTHYSEL 1294
Score = 34.3 bits (77), Expect = 0.22
Identities = 51/252 (20%), Positives = 113/252 (44%), Gaps = 31/252 (12%)
Query: 38 MLHLPSEQGAPETLQRCLEENQEL-------RDAIRQSNQILRE---RCEELLHFQASQ- 86
+L L SE+ ++ L+E Q L +D++ Q + + + + E+L + ++
Sbjct: 2436 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2495
Query: 87 ---REEKEFLMCKF-QEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASV 142
REE++ + QE ++LV + + +E R+ E L++ +QQ + + +
Sbjct: 2496 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2555
Query: 143 KAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREAL-------QQQH 195
+ L +LQ + + AA + + AA+ + L + R+AL + +H
Sbjct: 2556 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT---KTLPNGRDALDGPAAEAEPEH 2612
Query: 196 SVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 255
S + ++ Q ++ A + ++EE ++LAQ +L + D ++ + G
Sbjct: 2613 SFDGLRRKVSAQRLQEAGIL----SAEELQRLAQGHTTVDELARRED--VRHYLQGRSSI 2666
Query: 256 RGMQLEDLKQQL 267
G+ L+ ++L
Sbjct: 2667 AGLLLKATNEKL 2678
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 82.8 bits (203), Expect = 5e-16
Identities = 93/338 (27%), Positives = 155/338 (45%), Gaps = 38/338 (11%)
Query: 45 QGAPETLQRCLEENQELR-DAIRQSNQILR-----ERCEELLHFQASQREEKEFLMCKFQ 98
+G E +R EE +E R A R++ Q R ER ++ QA R + + K +
Sbjct: 2217 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2276
Query: 99 -EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQ 157
EA + R + RQK+ A E+E K+ +Q KA V+ ++T+L +L+E+
Sbjct: 2277 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2336
Query: 158 SRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMER 217
+ +E Q L+ A A+ Q Q+E E +++ VQ+++L +EA R
Sbjct: 2337 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEELSKLKARIEAENRALI 2392
Query: 218 QAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL--EDLKQQLQQAEEALV 275
+ ++ LQ ++ Q + + SV E R QL EDL QQ AE+ L
Sbjct: 2393 LRDKDNTQRF--LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2450
Query: 276 AKQEVID---KLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQ 332
K + + +LK EAE +L+ Q ++ A+ QAR +K+++ Q+
Sbjct: 2451 EKMQAVQEATRLKAEAE----------LLQQQKEL------AQEQARRLQEDKEQMAQQL 2494
Query: 333 LEQLQREYSKLKASCQE----SARIEDMRKRHVEVSQA 366
E+ Q L+A Q SA E ++ R E+S+A
Sbjct: 2495 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2532
Score = 77.8 bits (190), Expect = 2e-14
Identities = 82/322 (25%), Positives = 152/322 (47%), Gaps = 49/322 (15%)
Query: 56 EENQELRDAIR-QSNQILRERCEELLHFQASQ-REEKEFLMCKFQEA----RKLVERLGL 109
E+ Q +++A R ++ L ++ +EL QA + +E+KE + + E ++ +E
Sbjct: 2451 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510
Query: 110 EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKE--- 166
+L++ + E+ V + R Q + ED + Q E+ E R E AT+E
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEKVT 2566
Query: 167 -CQALEGRARAASEQAR-------QLESEREALQQQ-----------HSVQVDQLRMQGQ 207
Q LE + + + A +LE E+E LQQ+ +VQ +QL + Q
Sbjct: 2567 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2626
Query: 208 SVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQL 267
+++ + E+ + + +R + Q + QLFQ D K+ + E++R +QQ+
Sbjct: 2627 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ--DEVAKAQQLREEQQRQ------QQQM 2678
Query: 268 QQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKE 327
+Q + LVA E + + EAE+ V + Q ++ + + Q RQ E LAE+ +
Sbjct: 2679 EQERQRLVASMEEARRRQHEAEEG--------VRRKQEELQQLE-QQRRQQEELLAEENQ 2729
Query: 328 LLQEQLEQLQREYSKLKASCQE 349
L+EQL+ L+ ++ A +E
Sbjct: 2730 RLREQLQLLEEQHRAALAHSEE 2751
Score = 74.7 bits (182), Expect = 1e-13
Identities = 88/360 (24%), Positives = 154/360 (42%), Gaps = 62/360 (17%)
Query: 27 LGEESPLGKPAMLHLPSEQGAPETLQRCLEEN----QELRDAIRQSNQILRERCEELLHF 82
+GE + L A + L ++ E L+R E+ + L + Q + ER +L
Sbjct: 1979 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 2038
Query: 83 QASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASV 142
S+ E + + LVE D RQ+ Q E+ LK ++ A KA +
Sbjct: 2039 SDSELERQ----------KGLVE-------DTLRQRRQVEEEILALKASFEKAAAGKAEL 2081
Query: 143 KAQVTSLLGELQES-----QSRLEAATKECQALEG--RARAASEQARQLESEREALQQQH 195
+ ++ + +++ Q+ LEAA + A E R R A E+ ++ + E +Q
Sbjct: 2082 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 2141
Query: 196 SVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 255
++++ VE A R+ +A E R+L Q A + Q E+
Sbjct: 2142 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ-----------AEEKA 2190
Query: 256 RGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAE 315
++ +Q+LQQ L +Q V+D+L+ EAE + +A + +A QAE
Sbjct: 2191 HAFAVQQKEQELQQT---LQQEQSVLDQLRGEAEAAR---------RAAEEAEEARVQAE 2238
Query: 316 RQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRK-------RHVEVSQAPL 368
R+A + + +E E+L+Q E ++ +A Q +A E +RK R + QA L
Sbjct: 2239 REAAQSRRQVEE--AERLKQSAEEQAQARAQAQAAA--EKLRKEAEQEAARRAQAEQAAL 2294
Score = 74.3 bits (181), Expect = 2e-13
Identities = 96/388 (24%), Positives = 164/388 (42%), Gaps = 66/388 (17%)
Query: 41 LPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEE------LLHFQASQR----EEK 90
L +E+ A + LEE + L+ + ++ + LRER E+ L +A+Q+ EEK
Sbjct: 2131 LAAEEEAARQRKAALEEVERLKAKVEEARR-LRERAEQESARQLQLAQEAAQKRLQAEEK 2189
Query: 91 EFLMCKFQEARKLVERLGLEK--LD-LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVT 147
Q+ ++L + L E+ LD L+ + E A R E + + Q + A + QV
Sbjct: 2190 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2249
Query: 148 SLLGELQESQSRLEAATKECQALEG-RARAASEQARQLESEREALQQQHSVQVDQLRMQG 206
Q ++ + +A + A E R A E AR+ ++E+ AL+Q+ + + +
Sbjct: 2250 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE-MEKHK 2308
Query: 207 QSVEAALRMERQAASEEKRKLAQLQVAYHQ--LFQEYDNHIKSSVVGSERKRGM------ 258
+ E LR + Q E QL+ HQ L E +K+ + R+R
Sbjct: 2309 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2368
Query: 259 -------QLEDLKQQLQQAEEALVA--KQEVIDKLKEEAEQHKIVMETVPVLK------- 302
+L LK +++ AL+ K L+EEAE+ K V E L
Sbjct: 2369 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2428
Query: 303 -----AQADIYKADFQAERQAREK----------------LAEKKELLQEQLEQLQREYS 341
A+ D+ + AE+ +EK L ++KEL QEQ +LQ +
Sbjct: 2429 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2488
Query: 342 KLKASCQESAR-----IEDMRKRHVEVS 364
++ E + +E R+R +E+S
Sbjct: 2489 QMAQQLAEETQGFQRTLEAERQRQLEMS 2516
Score = 68.6 bits (166), Expect = 1e-11
Identities = 86/354 (24%), Positives = 163/354 (46%), Gaps = 41/354 (11%)
Query: 31 SPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILR------ERCEELLHFQA 84
SP KP + + G+ +Q ++ + ++Q ++ R EE
Sbjct: 1435 SPAKKPKV-----QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1489
Query: 85 SQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAE-DKASVK 143
QR E+ + + + A + +L K Q E+ +E++ +R Q+++ ++A+V
Sbjct: 1490 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVD 1547
Query: 144 AQVT--SLLGELQE----SQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSV 197
AQ S+ ELQ+ S++ ++A ++ +A E E+ R + + EA ++Q
Sbjct: 1548 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1607
Query: 198 QVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQ---EYDNHIKSSV-VGSE 253
+L+ E A +RQA E +R Q+Q + Q E + +K+ E
Sbjct: 1608 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1667
Query: 254 RKRGMQ-LEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADF 312
++R +Q LE+L+ Q ++AE L + EV E A Q ++ +ET AQ +A+
Sbjct: 1668 KQRALQALEELRLQAEEAERRL-RQAEV-----ERARQVQVALET-----AQRSA-EAEL 1715
Query: 313 QAERQA-REKLAEKKELLQEQ---LEQLQREYSKLKASCQESARIEDMRKRHVE 362
Q++R + EK A+ + LQE+ + QL+ E + E+ R + +R +E
Sbjct: 1716 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769
Score = 67.4 bits (163), Expect = 2e-11
Identities = 65/305 (21%), Positives = 141/305 (46%), Gaps = 32/305 (10%)
Query: 56 EENQELRDAIRQSNQILRER--CEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLD 113
E +EL ++N+ LR R EE+ ++ + E E + +EA + R G +
Sbjct: 1763 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQ 1819
Query: 114 LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGR 173
RQ+E A +E+E ++ + A+ + + + ++ L E ++ + + + +E L+
Sbjct: 1820 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1879
Query: 174 ARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVA 233
A AA+++ ++LE+E ++ + V + + +A E ++ SE+ ++ + +
Sbjct: 1880 AAAATQKRQELEAELAKVRAEMEVLL--------ASKARAEEESRSTSEKSKQRLEAEAG 1931
Query: 234 YHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKI 293
+ E +++ ++R+R + ED +Q +AE L K I +
Sbjct: 1932 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR------- 1984
Query: 294 VMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARI 353
LK +A+I + +AE + +LAE + + +LE+ ++ KA +E R+
Sbjct: 1985 -------LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH---KADIEE--RL 2032
Query: 354 EDMRK 358
+RK
Sbjct: 2033 AQLRK 2037
Score = 62.0 bits (149), Expect = 1e-09
Identities = 87/356 (24%), Positives = 165/356 (46%), Gaps = 48/356 (13%)
Query: 51 LQRCLEENQELRDAIRQSN-QILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL 109
++ LE+ ++L +A Q+ Q RE E Q +E + Q+ R + E L
Sbjct: 1502 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1561
Query: 110 EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLL-------GELQESQSRLE- 161
+ + + + R+ E +R + ++ E+ V+ Q+ + GELQ ++R E
Sbjct: 1562 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1621
Query: 162 ------AATKECQALEGRARAASEQARQLESE---------REALQQQHSVQ-VDQLRMQ 205
A +E + L + + S++ RQ E E A ++Q ++Q +++LR+Q
Sbjct: 1622 AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1681
Query: 206 GQSVEAALR---MER----QAASEEKRKLAQLQV-AYHQLFQEYDNHIKSSVVGSERKRG 257
+ E LR +ER Q A E ++ A+ ++ + F E ++ S+
Sbjct: 1682 AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1741
Query: 258 MQLEDLKQQLQQAEEALVAKQEVIDKLK------EEAEQHKIVMETVPVLK--AQADIYK 309
E+ +++ QQ EA A++E +L+ EA + ++ E V K AQA+ K
Sbjct: 1742 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1801
Query: 310 ADFQAERQAR------EKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKR 359
+AER+AR E+ ++EL +++LE+ QR+ ++ A + +A E +R R
Sbjct: 1802 QKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQELIRLR 1856
Score = 50.4 bits (119), Expect = 3e-06
Identities = 93/390 (23%), Positives = 157/390 (40%), Gaps = 70/390 (17%)
Query: 3 RHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELR 62
R L + +L + + + + L E + M L + + E R E + R
Sbjct: 1866 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1925
Query: 63 DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEA---RKLVERLGLEKLD------ 113
+ RE EE +A E K ++A R ER+ EKL
Sbjct: 1926 --LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1983
Query: 114 -LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEG 172
LK + E AL+E E +++AED+A + + L+E ++ +A +E A
Sbjct: 1984 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRR-------LEEQAAQHKADIEERLA--- 2033
Query: 173 RARAASEQARQLESER------EALQQQHSVQVDQLRMQGQSVEAA-------------- 212
+ R AS+ E ER + L+Q+ V+ + L ++ +AA
Sbjct: 2034 QLRKASDS----ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 2089
Query: 213 ------LRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSE---RKRGMQLEDL 263
LR + QA E R+ QL + +E + ++ S+ E R+R LE++
Sbjct: 2090 SNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2148
Query: 264 KQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLA 323
E L AK E +L+E AEQ E+ L+ + + QAE +A
Sbjct: 2149 --------ERLKAKVEEARRLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAV 2195
Query: 324 EKKEL-LQEQLEQLQREYSKLKASCQESAR 352
++KE LQ+ L+Q Q +L+ + + R
Sbjct: 2196 QQKEQELQQTLQQEQSVLDQLRGEAEAARR 2225
Score = 43.9 bits (102), Expect = 3e-04
Identities = 57/268 (21%), Positives = 116/268 (43%), Gaps = 16/268 (5%)
Query: 87 REEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQV 146
R E E + K ++ R L + LEKL + + E + R ++ ++ +V A
Sbjct: 1201 RSELELTLGKLEQVRSL-SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT- 1258
Query: 147 TSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQH---SVQVDQLR 203
L EL+ +++ L+ + +A + A ++ R + E LQQ+H V+V++ R
Sbjct: 1259 ---LPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1315
Query: 204 MQ-GQSVE--AALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL 260
+ Q +E A+ + E +L + Y + ++ + E+ + M L
Sbjct: 1316 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1375
Query: 261 ED---LKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQ--AE 315
D +++QL+Q + L + +K++E K + + + Q YKA + A
Sbjct: 1376 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1435
Query: 316 RQAREKLAEKKELLQEQLEQLQREYSKL 343
+ K+ E + ++ L+ YS+L
Sbjct: 1436 PAKKPKVQSGSESVIQEYVDLRTHYSEL 1463
Score = 34.3 bits (77), Expect = 0.22
Identities = 51/252 (20%), Positives = 113/252 (44%), Gaps = 31/252 (12%)
Query: 38 MLHLPSEQGAPETLQRCLEENQEL-------RDAIRQSNQILRE---RCEELLHFQASQ- 86
+L L SE+ ++ L+E Q L +D++ Q + + + + E+L + ++
Sbjct: 2605 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2664
Query: 87 ---REEKEFLMCKF-QEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASV 142
REE++ + QE ++LV + + +E R+ E L++ +QQ + + +
Sbjct: 2665 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2724
Query: 143 KAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREAL-------QQQH 195
+ L +LQ + + AA + + AA+ + L + R+AL + +H
Sbjct: 2725 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT---KTLPNGRDALDGPAAEAEPEH 2781
Query: 196 SVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 255
S + ++ Q ++ A + ++EE ++LAQ +L + D ++ + G
Sbjct: 2782 SFDGLRRKVSAQRLQEAGIL----SAEELQRLAQGHTTVDELARRED--VRHYLQGRSSI 2835
Query: 256 RGMQLEDLKQQL 267
G+ L+ ++L
Sbjct: 2836 AGLLLKATNEKL 2847
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 82.8 bits (203), Expect = 5e-16
Identities = 93/338 (27%), Positives = 155/338 (45%), Gaps = 38/338 (11%)
Query: 45 QGAPETLQRCLEENQELR-DAIRQSNQILR-----ERCEELLHFQASQREEKEFLMCKFQ 98
+G E +R EE +E R A R++ Q R ER ++ QA R + + K +
Sbjct: 2058 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2117
Query: 99 -EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQ 157
EA + R + RQK+ A E+E K+ +Q KA V+ ++T+L +L+E+
Sbjct: 2118 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2177
Query: 158 SRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMER 217
+ +E Q L+ A A+ Q Q+E E +++ VQ+++L +EA R
Sbjct: 2178 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEELSKLKARIEAENRALI 2233
Query: 218 QAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL--EDLKQQLQQAEEALV 275
+ ++ LQ ++ Q + + SV E R QL EDL QQ AE+ L
Sbjct: 2234 LRDKDNTQRF--LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2291
Query: 276 AKQEVID---KLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQ 332
K + + +LK EAE +L+ Q ++ A+ QAR +K+++ Q+
Sbjct: 2292 EKMQAVQEATRLKAEAE----------LLQQQKEL------AQEQARRLQEDKEQMAQQL 2335
Query: 333 LEQLQREYSKLKASCQE----SARIEDMRKRHVEVSQA 366
E+ Q L+A Q SA E ++ R E+S+A
Sbjct: 2336 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2373
Score = 77.8 bits (190), Expect = 2e-14
Identities = 82/322 (25%), Positives = 152/322 (47%), Gaps = 49/322 (15%)
Query: 56 EENQELRDAIR-QSNQILRERCEELLHFQASQ-REEKEFLMCKFQEA----RKLVERLGL 109
E+ Q +++A R ++ L ++ +EL QA + +E+KE + + E ++ +E
Sbjct: 2292 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351
Query: 110 EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKE--- 166
+L++ + E+ V + R Q + ED + Q E+ E R E AT+E
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEKVT 2407
Query: 167 -CQALEGRARAASEQAR-------QLESEREALQQQ-----------HSVQVDQLRMQGQ 207
Q LE + + + A +LE E+E LQQ+ +VQ +QL + Q
Sbjct: 2408 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2467
Query: 208 SVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQL 267
+++ + E+ + + +R + Q + QLFQ D K+ + E++R +QQ+
Sbjct: 2468 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ--DEVAKAQQLREEQQRQ------QQQM 2519
Query: 268 QQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKE 327
+Q + LVA E + + EAE+ V + Q ++ + + Q RQ E LAE+ +
Sbjct: 2520 EQERQRLVASMEEARRRQHEAEEG--------VRRKQEELQQLE-QQRRQQEELLAEENQ 2570
Query: 328 LLQEQLEQLQREYSKLKASCQE 349
L+EQL+ L+ ++ A +E
Sbjct: 2571 RLREQLQLLEEQHRAALAHSEE 2592
Score = 74.7 bits (182), Expect = 1e-13
Identities = 88/360 (24%), Positives = 154/360 (42%), Gaps = 62/360 (17%)
Query: 27 LGEESPLGKPAMLHLPSEQGAPETLQRCLEEN----QELRDAIRQSNQILRERCEELLHF 82
+GE + L A + L ++ E L+R E+ + L + Q + ER +L
Sbjct: 1820 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1879
Query: 83 QASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASV 142
S+ E + + LVE D RQ+ Q E+ LK ++ A KA +
Sbjct: 1880 SDSELERQ----------KGLVE-------DTLRQRRQVEEEILALKASFEKAAAGKAEL 1922
Query: 143 KAQVTSLLGELQES-----QSRLEAATKECQALEG--RARAASEQARQLESEREALQQQH 195
+ ++ + +++ Q+ LEAA + A E R R A E+ ++ + E +Q
Sbjct: 1923 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 1982
Query: 196 SVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 255
++++ VE A R+ +A E R+L Q A + Q E+
Sbjct: 1983 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ-----------AEEKA 2031
Query: 256 RGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAE 315
++ +Q+LQQ L +Q V+D+L+ EAE + +A + +A QAE
Sbjct: 2032 HAFAVQQKEQELQQT---LQQEQSVLDQLRGEAEAAR---------RAAEEAEEARVQAE 2079
Query: 316 RQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRK-------RHVEVSQAPL 368
R+A + + +E E+L+Q E ++ +A Q +A E +RK R + QA L
Sbjct: 2080 REAAQSRRQVEE--AERLKQSAEEQAQARAQAQAAA--EKLRKEAEQEAARRAQAEQAAL 2135
Score = 74.3 bits (181), Expect = 2e-13
Identities = 96/388 (24%), Positives = 164/388 (42%), Gaps = 66/388 (17%)
Query: 41 LPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEE------LLHFQASQR----EEK 90
L +E+ A + LEE + L+ + ++ + LRER E+ L +A+Q+ EEK
Sbjct: 1972 LAAEEEAARQRKAALEEVERLKAKVEEARR-LRERAEQESARQLQLAQEAAQKRLQAEEK 2030
Query: 91 EFLMCKFQEARKLVERLGLEK--LD-LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVT 147
Q+ ++L + L E+ LD L+ + E A R E + + Q + A + QV
Sbjct: 2031 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2090
Query: 148 SLLGELQESQSRLEAATKECQALEG-RARAASEQARQLESEREALQQQHSVQVDQLRMQG 206
Q ++ + +A + A E R A E AR+ ++E+ AL+Q+ + + +
Sbjct: 2091 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE-MEKHK 2149
Query: 207 QSVEAALRMERQAASEEKRKLAQLQVAYHQ--LFQEYDNHIKSSVVGSERKRGM------ 258
+ E LR + Q E QL+ HQ L E +K+ + R+R
Sbjct: 2150 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2209
Query: 259 -------QLEDLKQQLQQAEEALVA--KQEVIDKLKEEAEQHKIVMETVPVLK------- 302
+L LK +++ AL+ K L+EEAE+ K V E L
Sbjct: 2210 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2269
Query: 303 -----AQADIYKADFQAERQAREK----------------LAEKKELLQEQLEQLQREYS 341
A+ D+ + AE+ +EK L ++KEL QEQ +LQ +
Sbjct: 2270 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2329
Query: 342 KLKASCQESAR-----IEDMRKRHVEVS 364
++ E + +E R+R +E+S
Sbjct: 2330 QMAQQLAEETQGFQRTLEAERQRQLEMS 2357
Score = 68.6 bits (166), Expect = 1e-11
Identities = 86/354 (24%), Positives = 163/354 (46%), Gaps = 41/354 (11%)
Query: 31 SPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILR------ERCEELLHFQA 84
SP KP + + G+ +Q ++ + ++Q ++ R EE
Sbjct: 1276 SPAKKPKV-----QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1330
Query: 85 SQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAE-DKASVK 143
QR E+ + + + A + +L K Q E+ +E++ +R Q+++ ++A+V
Sbjct: 1331 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVD 1388
Query: 144 AQVT--SLLGELQE----SQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSV 197
AQ S+ ELQ+ S++ ++A ++ +A E E+ R + + EA ++Q
Sbjct: 1389 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1448
Query: 198 QVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQ---EYDNHIKSSV-VGSE 253
+L+ E A +RQA E +R Q+Q + Q E + +K+ E
Sbjct: 1449 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1508
Query: 254 RKRGMQ-LEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADF 312
++R +Q LE+L+ Q ++AE L + EV E A Q ++ +ET AQ +A+
Sbjct: 1509 KQRALQALEELRLQAEEAERRL-RQAEV-----ERARQVQVALET-----AQRSA-EAEL 1556
Query: 313 QAERQA-REKLAEKKELLQEQ---LEQLQREYSKLKASCQESARIEDMRKRHVE 362
Q++R + EK A+ + LQE+ + QL+ E + E+ R + +R +E
Sbjct: 1557 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1610
Score = 67.4 bits (163), Expect = 2e-11
Identities = 65/305 (21%), Positives = 141/305 (46%), Gaps = 32/305 (10%)
Query: 56 EENQELRDAIRQSNQILRER--CEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLD 113
E +EL ++N+ LR R EE+ ++ + E E + +EA + R G +
Sbjct: 1604 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQ 1660
Query: 114 LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGR 173
RQ+E A +E+E ++ + A+ + + + ++ L E ++ + + + +E L+
Sbjct: 1661 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1720
Query: 174 ARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVA 233
A AA+++ ++LE+E ++ + V + + +A E ++ SE+ ++ + +
Sbjct: 1721 AAAATQKRQELEAELAKVRAEMEVLL--------ASKARAEEESRSTSEKSKQRLEAEAG 1772
Query: 234 YHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKI 293
+ E +++ ++R+R + ED +Q +AE L K I +
Sbjct: 1773 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR------- 1825
Query: 294 VMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARI 353
LK +A+I + +AE + +LAE + + +LE+ ++ KA +E R+
Sbjct: 1826 -------LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH---KADIEE--RL 1873
Query: 354 EDMRK 358
+RK
Sbjct: 1874 AQLRK 1878
Score = 62.0 bits (149), Expect = 1e-09
Identities = 87/356 (24%), Positives = 165/356 (46%), Gaps = 48/356 (13%)
Query: 51 LQRCLEENQELRDAIRQSN-QILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL 109
++ LE+ ++L +A Q+ Q RE E Q +E + Q+ R + E L
Sbjct: 1343 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1402
Query: 110 EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLL-------GELQESQSRLE- 161
+ + + + R+ E +R + ++ E+ V+ Q+ + GELQ ++R E
Sbjct: 1403 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1462
Query: 162 ------AATKECQALEGRARAASEQARQLESE---------REALQQQHSVQ-VDQLRMQ 205
A +E + L + + S++ RQ E E A ++Q ++Q +++LR+Q
Sbjct: 1463 AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1522
Query: 206 GQSVEAALR---MER----QAASEEKRKLAQLQV-AYHQLFQEYDNHIKSSVVGSERKRG 257
+ E LR +ER Q A E ++ A+ ++ + F E ++ S+
Sbjct: 1523 AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1582
Query: 258 MQLEDLKQQLQQAEEALVAKQEVIDKLK------EEAEQHKIVMETVPVLK--AQADIYK 309
E+ +++ QQ EA A++E +L+ EA + ++ E V K AQA+ K
Sbjct: 1583 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1642
Query: 310 ADFQAERQAR------EKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKR 359
+AER+AR E+ ++EL +++LE+ QR+ ++ A + +A E +R R
Sbjct: 1643 QKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQELIRLR 1697
Score = 50.4 bits (119), Expect = 3e-06
Identities = 93/390 (23%), Positives = 157/390 (40%), Gaps = 70/390 (17%)
Query: 3 RHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELR 62
R L + +L + + + + L E + M L + + E R E + R
Sbjct: 1707 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1766
Query: 63 DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEA---RKLVERLGLEKLD------ 113
+ RE EE +A E K ++A R ER+ EKL
Sbjct: 1767 --LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1824
Query: 114 -LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEG 172
LK + E AL+E E +++AED+A + + L+E ++ +A +E A
Sbjct: 1825 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRR-------LEEQAAQHKADIEERLA--- 1874
Query: 173 RARAASEQARQLESER------EALQQQHSVQVDQLRMQGQSVEAA-------------- 212
+ R AS+ E ER + L+Q+ V+ + L ++ +AA
Sbjct: 1875 QLRKASDS----ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1930
Query: 213 ------LRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSE---RKRGMQLEDL 263
LR + QA E R+ QL + +E + ++ S+ E R+R LE++
Sbjct: 1931 SNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1989
Query: 264 KQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLA 323
E L AK E +L+E AEQ E+ L+ + + QAE +A
Sbjct: 1990 --------ERLKAKVEEARRLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAV 2036
Query: 324 EKKEL-LQEQLEQLQREYSKLKASCQESAR 352
++KE LQ+ L+Q Q +L+ + + R
Sbjct: 2037 QQKEQELQQTLQQEQSVLDQLRGEAEAARR 2066
Score = 43.9 bits (102), Expect = 3e-04
Identities = 57/268 (21%), Positives = 116/268 (43%), Gaps = 16/268 (5%)
Query: 87 REEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQV 146
R E E + K ++ R L + LEKL + + E + R ++ ++ +V A
Sbjct: 1042 RSELELTLGKLEQVRSL-SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT- 1099
Query: 147 TSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQH---SVQVDQLR 203
L EL+ +++ L+ + +A + A ++ R + E LQQ+H V+V++ R
Sbjct: 1100 ---LPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1156
Query: 204 MQ-GQSVE--AALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL 260
+ Q +E A+ + E +L + Y + ++ + E+ + M L
Sbjct: 1157 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1216
Query: 261 ED---LKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQ--AE 315
D +++QL+Q + L + +K++E K + + + Q YKA + A
Sbjct: 1217 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1276
Query: 316 RQAREKLAEKKELLQEQLEQLQREYSKL 343
+ K+ E + ++ L+ YS+L
Sbjct: 1277 PAKKPKVQSGSESVIQEYVDLRTHYSEL 1304
Score = 34.3 bits (77), Expect = 0.22
Identities = 51/252 (20%), Positives = 113/252 (44%), Gaps = 31/252 (12%)
Query: 38 MLHLPSEQGAPETLQRCLEENQEL-------RDAIRQSNQILRE---RCEELLHFQASQ- 86
+L L SE+ ++ L+E Q L +D++ Q + + + + E+L + ++
Sbjct: 2446 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2505
Query: 87 ---REEKEFLMCKF-QEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASV 142
REE++ + QE ++LV + + +E R+ E L++ +QQ + + +
Sbjct: 2506 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2565
Query: 143 KAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREAL-------QQQH 195
+ L +LQ + + AA + + AA+ + L + R+AL + +H
Sbjct: 2566 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT---KTLPNGRDALDGPAAEAEPEH 2622
Query: 196 SVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 255
S + ++ Q ++ A + ++EE ++LAQ +L + D ++ + G
Sbjct: 2623 SFDGLRRKVSAQRLQEAGIL----SAEELQRLAQGHTTVDELARRED--VRHYLQGRSSI 2676
Query: 256 RGMQLEDLKQQL 267
G+ L+ ++L
Sbjct: 2677 AGLLLKATNEKL 2688
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 82.8 bits (203), Expect = 5e-16
Identities = 93/338 (27%), Positives = 155/338 (45%), Gaps = 38/338 (11%)
Query: 45 QGAPETLQRCLEENQELR-DAIRQSNQILR-----ERCEELLHFQASQREEKEFLMCKFQ 98
+G E +R EE +E R A R++ Q R ER ++ QA R + + K +
Sbjct: 2066 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2125
Query: 99 -EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQ 157
EA + R + RQK+ A E+E K+ +Q KA V+ ++T+L +L+E+
Sbjct: 2126 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2185
Query: 158 SRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMER 217
+ +E Q L+ A A+ Q Q+E E +++ VQ+++L +EA R
Sbjct: 2186 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEELSKLKARIEAENRALI 2241
Query: 218 QAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL--EDLKQQLQQAEEALV 275
+ ++ LQ ++ Q + + SV E R QL EDL QQ AE+ L
Sbjct: 2242 LRDKDNTQRF--LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2299
Query: 276 AKQEVID---KLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQ 332
K + + +LK EAE +L+ Q ++ A+ QAR +K+++ Q+
Sbjct: 2300 EKMQAVQEATRLKAEAE----------LLQQQKEL------AQEQARRLQEDKEQMAQQL 2343
Query: 333 LEQLQREYSKLKASCQE----SARIEDMRKRHVEVSQA 366
E+ Q L+A Q SA E ++ R E+S+A
Sbjct: 2344 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2381
Score = 77.8 bits (190), Expect = 2e-14
Identities = 82/322 (25%), Positives = 152/322 (47%), Gaps = 49/322 (15%)
Query: 56 EENQELRDAIR-QSNQILRERCEELLHFQASQ-REEKEFLMCKFQEA----RKLVERLGL 109
E+ Q +++A R ++ L ++ +EL QA + +E+KE + + E ++ +E
Sbjct: 2300 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2359
Query: 110 EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKE--- 166
+L++ + E+ V + R Q + ED + Q E+ E R E AT+E
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEKVT 2415
Query: 167 -CQALEGRARAASEQAR-------QLESEREALQQQ-----------HSVQVDQLRMQGQ 207
Q LE + + + A +LE E+E LQQ+ +VQ +QL + Q
Sbjct: 2416 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2475
Query: 208 SVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQL 267
+++ + E+ + + +R + Q + QLFQ D K+ + E++R +QQ+
Sbjct: 2476 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ--DEVAKAQQLREEQQRQ------QQQM 2527
Query: 268 QQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKE 327
+Q + LVA E + + EAE+ V + Q ++ + + Q RQ E LAE+ +
Sbjct: 2528 EQERQRLVASMEEARRRQHEAEEG--------VRRKQEELQQLE-QQRRQQEELLAEENQ 2578
Query: 328 LLQEQLEQLQREYSKLKASCQE 349
L+EQL+ L+ ++ A +E
Sbjct: 2579 RLREQLQLLEEQHRAALAHSEE 2600
Score = 74.7 bits (182), Expect = 1e-13
Identities = 88/360 (24%), Positives = 154/360 (42%), Gaps = 62/360 (17%)
Query: 27 LGEESPLGKPAMLHLPSEQGAPETLQRCLEEN----QELRDAIRQSNQILRERCEELLHF 82
+GE + L A + L ++ E L+R E+ + L + Q + ER +L
Sbjct: 1828 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1887
Query: 83 QASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASV 142
S+ E + + LVE D RQ+ Q E+ LK ++ A KA +
Sbjct: 1888 SDSELERQ----------KGLVE-------DTLRQRRQVEEEILALKASFEKAAAGKAEL 1930
Query: 143 KAQVTSLLGELQES-----QSRLEAATKECQALEG--RARAASEQARQLESEREALQQQH 195
+ ++ + +++ Q+ LEAA + A E R R A E+ ++ + E +Q
Sbjct: 1931 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 1990
Query: 196 SVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 255
++++ VE A R+ +A E R+L Q A + Q E+
Sbjct: 1991 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ-----------AEEKA 2039
Query: 256 RGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAE 315
++ +Q+LQQ L +Q V+D+L+ EAE + +A + +A QAE
Sbjct: 2040 HAFAVQQKEQELQQT---LQQEQSVLDQLRGEAEAAR---------RAAEEAEEARVQAE 2087
Query: 316 RQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRK-------RHVEVSQAPL 368
R+A + + +E E+L+Q E ++ +A Q +A E +RK R + QA L
Sbjct: 2088 REAAQSRRQVEE--AERLKQSAEEQAQARAQAQAAA--EKLRKEAEQEAARRAQAEQAAL 2143
Score = 74.3 bits (181), Expect = 2e-13
Identities = 96/388 (24%), Positives = 164/388 (42%), Gaps = 66/388 (17%)
Query: 41 LPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEE------LLHFQASQR----EEK 90
L +E+ A + LEE + L+ + ++ + LRER E+ L +A+Q+ EEK
Sbjct: 1980 LAAEEEAARQRKAALEEVERLKAKVEEARR-LRERAEQESARQLQLAQEAAQKRLQAEEK 2038
Query: 91 EFLMCKFQEARKLVERLGLEK--LD-LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVT 147
Q+ ++L + L E+ LD L+ + E A R E + + Q + A + QV
Sbjct: 2039 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2098
Query: 148 SLLGELQESQSRLEAATKECQALEG-RARAASEQARQLESEREALQQQHSVQVDQLRMQG 206
Q ++ + +A + A E R A E AR+ ++E+ AL+Q+ + + +
Sbjct: 2099 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE-MEKHK 2157
Query: 207 QSVEAALRMERQAASEEKRKLAQLQVAYHQ--LFQEYDNHIKSSVVGSERKRGM------ 258
+ E LR + Q E QL+ HQ L E +K+ + R+R
Sbjct: 2158 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2217
Query: 259 -------QLEDLKQQLQQAEEALVA--KQEVIDKLKEEAEQHKIVMETVPVLK------- 302
+L LK +++ AL+ K L+EEAE+ K V E L
Sbjct: 2218 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2277
Query: 303 -----AQADIYKADFQAERQAREK----------------LAEKKELLQEQLEQLQREYS 341
A+ D+ + AE+ +EK L ++KEL QEQ +LQ +
Sbjct: 2278 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2337
Query: 342 KLKASCQESAR-----IEDMRKRHVEVS 364
++ E + +E R+R +E+S
Sbjct: 2338 QMAQQLAEETQGFQRTLEAERQRQLEMS 2365
Score = 68.6 bits (166), Expect = 1e-11
Identities = 86/354 (24%), Positives = 163/354 (46%), Gaps = 41/354 (11%)
Query: 31 SPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILR------ERCEELLHFQA 84
SP KP + + G+ +Q ++ + ++Q ++ R EE
Sbjct: 1284 SPAKKPKV-----QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1338
Query: 85 SQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAE-DKASVK 143
QR E+ + + + A + +L K Q E+ +E++ +R Q+++ ++A+V
Sbjct: 1339 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVD 1396
Query: 144 AQVT--SLLGELQE----SQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSV 197
AQ S+ ELQ+ S++ ++A ++ +A E E+ R + + EA ++Q
Sbjct: 1397 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1456
Query: 198 QVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQ---EYDNHIKSSV-VGSE 253
+L+ E A +RQA E +R Q+Q + Q E + +K+ E
Sbjct: 1457 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1516
Query: 254 RKRGMQ-LEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADF 312
++R +Q LE+L+ Q ++AE L + EV E A Q ++ +ET AQ +A+
Sbjct: 1517 KQRALQALEELRLQAEEAERRL-RQAEV-----ERARQVQVALET-----AQRSA-EAEL 1564
Query: 313 QAERQA-REKLAEKKELLQEQ---LEQLQREYSKLKASCQESARIEDMRKRHVE 362
Q++R + EK A+ + LQE+ + QL+ E + E+ R + +R +E
Sbjct: 1565 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1618
Score = 67.4 bits (163), Expect = 2e-11
Identities = 65/305 (21%), Positives = 141/305 (46%), Gaps = 32/305 (10%)
Query: 56 EENQELRDAIRQSNQILRER--CEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLD 113
E +EL ++N+ LR R EE+ ++ + E E + +EA + R G +
Sbjct: 1612 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQ 1668
Query: 114 LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGR 173
RQ+E A +E+E ++ + A+ + + + ++ L E ++ + + + +E L+
Sbjct: 1669 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1728
Query: 174 ARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVA 233
A AA+++ ++LE+E ++ + V + + +A E ++ SE+ ++ + +
Sbjct: 1729 AAAATQKRQELEAELAKVRAEMEVLL--------ASKARAEEESRSTSEKSKQRLEAEAG 1780
Query: 234 YHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKI 293
+ E +++ ++R+R + ED +Q +AE L K I +
Sbjct: 1781 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR------- 1833
Query: 294 VMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARI 353
LK +A+I + +AE + +LAE + + +LE+ ++ KA +E R+
Sbjct: 1834 -------LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH---KADIEE--RL 1881
Query: 354 EDMRK 358
+RK
Sbjct: 1882 AQLRK 1886
Score = 62.0 bits (149), Expect = 1e-09
Identities = 87/356 (24%), Positives = 165/356 (46%), Gaps = 48/356 (13%)
Query: 51 LQRCLEENQELRDAIRQSN-QILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL 109
++ LE+ ++L +A Q+ Q RE E Q +E + Q+ R + E L
Sbjct: 1351 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1410
Query: 110 EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLL-------GELQESQSRLE- 161
+ + + + R+ E +R + ++ E+ V+ Q+ + GELQ ++R E
Sbjct: 1411 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1470
Query: 162 ------AATKECQALEGRARAASEQARQLESE---------REALQQQHSVQ-VDQLRMQ 205
A +E + L + + S++ RQ E E A ++Q ++Q +++LR+Q
Sbjct: 1471 AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1530
Query: 206 GQSVEAALR---MER----QAASEEKRKLAQLQV-AYHQLFQEYDNHIKSSVVGSERKRG 257
+ E LR +ER Q A E ++ A+ ++ + F E ++ S+
Sbjct: 1531 AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1590
Query: 258 MQLEDLKQQLQQAEEALVAKQEVIDKLK------EEAEQHKIVMETVPVLK--AQADIYK 309
E+ +++ QQ EA A++E +L+ EA + ++ E V K AQA+ K
Sbjct: 1591 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1650
Query: 310 ADFQAERQAR------EKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKR 359
+AER+AR E+ ++EL +++LE+ QR+ ++ A + +A E +R R
Sbjct: 1651 QKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQELIRLR 1705
Score = 50.4 bits (119), Expect = 3e-06
Identities = 93/390 (23%), Positives = 157/390 (40%), Gaps = 70/390 (17%)
Query: 3 RHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELR 62
R L + +L + + + + L E + M L + + E R E + R
Sbjct: 1715 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1774
Query: 63 DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEA---RKLVERLGLEKLD------ 113
+ RE EE +A E K ++A R ER+ EKL
Sbjct: 1775 --LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1832
Query: 114 -LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEG 172
LK + E AL+E E +++AED+A + + L+E ++ +A +E A
Sbjct: 1833 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRR-------LEEQAAQHKADIEERLA--- 1882
Query: 173 RARAASEQARQLESER------EALQQQHSVQVDQLRMQGQSVEAA-------------- 212
+ R AS+ E ER + L+Q+ V+ + L ++ +AA
Sbjct: 1883 QLRKASDS----ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1938
Query: 213 ------LRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSE---RKRGMQLEDL 263
LR + QA E R+ QL + +E + ++ S+ E R+R LE++
Sbjct: 1939 SNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1997
Query: 264 KQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLA 323
E L AK E +L+E AEQ E+ L+ + + QAE +A
Sbjct: 1998 --------ERLKAKVEEARRLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAV 2044
Query: 324 EKKEL-LQEQLEQLQREYSKLKASCQESAR 352
++KE LQ+ L+Q Q +L+ + + R
Sbjct: 2045 QQKEQELQQTLQQEQSVLDQLRGEAEAARR 2074
Score = 43.9 bits (102), Expect = 3e-04
Identities = 57/268 (21%), Positives = 116/268 (43%), Gaps = 16/268 (5%)
Query: 87 REEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQV 146
R E E + K ++ R L + LEKL + + E + R ++ ++ +V A
Sbjct: 1050 RSELELTLGKLEQVRSL-SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT- 1107
Query: 147 TSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQH---SVQVDQLR 203
L EL+ +++ L+ + +A + A ++ R + E LQQ+H V+V++ R
Sbjct: 1108 ---LPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1164
Query: 204 MQ-GQSVE--AALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL 260
+ Q +E A+ + E +L + Y + ++ + E+ + M L
Sbjct: 1165 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1224
Query: 261 ED---LKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQ--AE 315
D +++QL+Q + L + +K++E K + + + Q YKA + A
Sbjct: 1225 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1284
Query: 316 RQAREKLAEKKELLQEQLEQLQREYSKL 343
+ K+ E + ++ L+ YS+L
Sbjct: 1285 PAKKPKVQSGSESVIQEYVDLRTHYSEL 1312
Score = 34.3 bits (77), Expect = 0.22
Identities = 51/252 (20%), Positives = 113/252 (44%), Gaps = 31/252 (12%)
Query: 38 MLHLPSEQGAPETLQRCLEENQEL-------RDAIRQSNQILRE---RCEELLHFQASQ- 86
+L L SE+ ++ L+E Q L +D++ Q + + + + E+L + ++
Sbjct: 2454 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2513
Query: 87 ---REEKEFLMCKF-QEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASV 142
REE++ + QE ++LV + + +E R+ E L++ +QQ + + +
Sbjct: 2514 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2573
Query: 143 KAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREAL-------QQQH 195
+ L +LQ + + AA + + AA+ + L + R+AL + +H
Sbjct: 2574 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT---KTLPNGRDALDGPAAEAEPEH 2630
Query: 196 SVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 255
S + ++ Q ++ A + ++EE ++LAQ +L + D ++ + G
Sbjct: 2631 SFDGLRRKVSAQRLQEAGIL----SAEELQRLAQGHTTVDELARRED--VRHYLQGRSSI 2684
Query: 256 RGMQLEDLKQQL 267
G+ L+ ++L
Sbjct: 2685 AGLLLKATNEKL 2696
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 82.8 bits (203), Expect = 5e-16
Identities = 93/338 (27%), Positives = 155/338 (45%), Gaps = 38/338 (11%)
Query: 45 QGAPETLQRCLEENQELR-DAIRQSNQILR-----ERCEELLHFQASQREEKEFLMCKFQ 98
+G E +R EE +E R A R++ Q R ER ++ QA R + + K +
Sbjct: 2107 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2166
Query: 99 -EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQ 157
EA + R + RQK+ A E+E K+ +Q KA V+ ++T+L +L+E+
Sbjct: 2167 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2226
Query: 158 SRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMER 217
+ +E Q L+ A A+ Q Q+E E +++ VQ+++L +EA R
Sbjct: 2227 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEELSKLKARIEAENRALI 2282
Query: 218 QAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL--EDLKQQLQQAEEALV 275
+ ++ LQ ++ Q + + SV E R QL EDL QQ AE+ L
Sbjct: 2283 LRDKDNTQRF--LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2340
Query: 276 AKQEVID---KLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQ 332
K + + +LK EAE +L+ Q ++ A+ QAR +K+++ Q+
Sbjct: 2341 EKMQAVQEATRLKAEAE----------LLQQQKEL------AQEQARRLQEDKEQMAQQL 2384
Query: 333 LEQLQREYSKLKASCQE----SARIEDMRKRHVEVSQA 366
E+ Q L+A Q SA E ++ R E+S+A
Sbjct: 2385 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2422
Score = 77.8 bits (190), Expect = 2e-14
Identities = 82/322 (25%), Positives = 152/322 (47%), Gaps = 49/322 (15%)
Query: 56 EENQELRDAIR-QSNQILRERCEELLHFQASQ-REEKEFLMCKFQEA----RKLVERLGL 109
E+ Q +++A R ++ L ++ +EL QA + +E+KE + + E ++ +E
Sbjct: 2341 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400
Query: 110 EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKE--- 166
+L++ + E+ V + R Q + ED + Q E+ E R E AT+E
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEKVT 2456
Query: 167 -CQALEGRARAASEQAR-------QLESEREALQQQ-----------HSVQVDQLRMQGQ 207
Q LE + + + A +LE E+E LQQ+ +VQ +QL + Q
Sbjct: 2457 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2516
Query: 208 SVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQL 267
+++ + E+ + + +R + Q + QLFQ D K+ + E++R +QQ+
Sbjct: 2517 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ--DEVAKAQQLREEQQRQ------QQQM 2568
Query: 268 QQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKE 327
+Q + LVA E + + EAE+ V + Q ++ + + Q RQ E LAE+ +
Sbjct: 2569 EQERQRLVASMEEARRRQHEAEEG--------VRRKQEELQQLE-QQRRQQEELLAEENQ 2619
Query: 328 LLQEQLEQLQREYSKLKASCQE 349
L+EQL+ L+ ++ A +E
Sbjct: 2620 RLREQLQLLEEQHRAALAHSEE 2641
Score = 74.7 bits (182), Expect = 1e-13
Identities = 88/360 (24%), Positives = 154/360 (42%), Gaps = 62/360 (17%)
Query: 27 LGEESPLGKPAMLHLPSEQGAPETLQRCLEEN----QELRDAIRQSNQILRERCEELLHF 82
+GE + L A + L ++ E L+R E+ + L + Q + ER +L
Sbjct: 1869 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1928
Query: 83 QASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASV 142
S+ E + + LVE D RQ+ Q E+ LK ++ A KA +
Sbjct: 1929 SDSELERQ----------KGLVE-------DTLRQRRQVEEEILALKASFEKAAAGKAEL 1971
Query: 143 KAQVTSLLGELQES-----QSRLEAATKECQALEG--RARAASEQARQLESEREALQQQH 195
+ ++ + +++ Q+ LEAA + A E R R A E+ ++ + E +Q
Sbjct: 1972 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 2031
Query: 196 SVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 255
++++ VE A R+ +A E R+L Q A + Q E+
Sbjct: 2032 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ-----------AEEKA 2080
Query: 256 RGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAE 315
++ +Q+LQQ L +Q V+D+L+ EAE + +A + +A QAE
Sbjct: 2081 HAFAVQQKEQELQQT---LQQEQSVLDQLRGEAEAAR---------RAAEEAEEARVQAE 2128
Query: 316 RQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRK-------RHVEVSQAPL 368
R+A + + +E E+L+Q E ++ +A Q +A E +RK R + QA L
Sbjct: 2129 REAAQSRRQVEE--AERLKQSAEEQAQARAQAQAAA--EKLRKEAEQEAARRAQAEQAAL 2184
Score = 74.3 bits (181), Expect = 2e-13
Identities = 96/388 (24%), Positives = 164/388 (42%), Gaps = 66/388 (17%)
Query: 41 LPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEE------LLHFQASQR----EEK 90
L +E+ A + LEE + L+ + ++ + LRER E+ L +A+Q+ EEK
Sbjct: 2021 LAAEEEAARQRKAALEEVERLKAKVEEARR-LRERAEQESARQLQLAQEAAQKRLQAEEK 2079
Query: 91 EFLMCKFQEARKLVERLGLEK--LD-LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVT 147
Q+ ++L + L E+ LD L+ + E A R E + + Q + A + QV
Sbjct: 2080 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2139
Query: 148 SLLGELQESQSRLEAATKECQALEG-RARAASEQARQLESEREALQQQHSVQVDQLRMQG 206
Q ++ + +A + A E R A E AR+ ++E+ AL+Q+ + + +
Sbjct: 2140 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE-MEKHK 2198
Query: 207 QSVEAALRMERQAASEEKRKLAQLQVAYHQ--LFQEYDNHIKSSVVGSERKRGM------ 258
+ E LR + Q E QL+ HQ L E +K+ + R+R
Sbjct: 2199 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2258
Query: 259 -------QLEDLKQQLQQAEEALVA--KQEVIDKLKEEAEQHKIVMETVPVLK------- 302
+L LK +++ AL+ K L+EEAE+ K V E L
Sbjct: 2259 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2318
Query: 303 -----AQADIYKADFQAERQAREK----------------LAEKKELLQEQLEQLQREYS 341
A+ D+ + AE+ +EK L ++KEL QEQ +LQ +
Sbjct: 2319 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2378
Query: 342 KLKASCQESAR-----IEDMRKRHVEVS 364
++ E + +E R+R +E+S
Sbjct: 2379 QMAQQLAEETQGFQRTLEAERQRQLEMS 2406
Score = 68.6 bits (166), Expect = 1e-11
Identities = 86/354 (24%), Positives = 163/354 (46%), Gaps = 41/354 (11%)
Query: 31 SPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILR------ERCEELLHFQA 84
SP KP + + G+ +Q ++ + ++Q ++ R EE
Sbjct: 1325 SPAKKPKV-----QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1379
Query: 85 SQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAE-DKASVK 143
QR E+ + + + A + +L K Q E+ +E++ +R Q+++ ++A+V
Sbjct: 1380 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVD 1437
Query: 144 AQVT--SLLGELQE----SQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSV 197
AQ S+ ELQ+ S++ ++A ++ +A E E+ R + + EA ++Q
Sbjct: 1438 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1497
Query: 198 QVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQ---EYDNHIKSSV-VGSE 253
+L+ E A +RQA E +R Q+Q + Q E + +K+ E
Sbjct: 1498 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1557
Query: 254 RKRGMQ-LEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADF 312
++R +Q LE+L+ Q ++AE L + EV E A Q ++ +ET AQ +A+
Sbjct: 1558 KQRALQALEELRLQAEEAERRL-RQAEV-----ERARQVQVALET-----AQRSA-EAEL 1605
Query: 313 QAERQA-REKLAEKKELLQEQ---LEQLQREYSKLKASCQESARIEDMRKRHVE 362
Q++R + EK A+ + LQE+ + QL+ E + E+ R + +R +E
Sbjct: 1606 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1659
Score = 67.4 bits (163), Expect = 2e-11
Identities = 65/305 (21%), Positives = 141/305 (46%), Gaps = 32/305 (10%)
Query: 56 EENQELRDAIRQSNQILRER--CEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLD 113
E +EL ++N+ LR R EE+ ++ + E E + +EA + R G +
Sbjct: 1653 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQ 1709
Query: 114 LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGR 173
RQ+E A +E+E ++ + A+ + + + ++ L E ++ + + + +E L+
Sbjct: 1710 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1769
Query: 174 ARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVA 233
A AA+++ ++LE+E ++ + V + + +A E ++ SE+ ++ + +
Sbjct: 1770 AAAATQKRQELEAELAKVRAEMEVLL--------ASKARAEEESRSTSEKSKQRLEAEAG 1821
Query: 234 YHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKI 293
+ E +++ ++R+R + ED +Q +AE L K I +
Sbjct: 1822 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR------- 1874
Query: 294 VMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARI 353
LK +A+I + +AE + +LAE + + +LE+ ++ KA +E R+
Sbjct: 1875 -------LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH---KADIEE--RL 1922
Query: 354 EDMRK 358
+RK
Sbjct: 1923 AQLRK 1927
Score = 62.0 bits (149), Expect = 1e-09
Identities = 87/356 (24%), Positives = 165/356 (46%), Gaps = 48/356 (13%)
Query: 51 LQRCLEENQELRDAIRQSN-QILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL 109
++ LE+ ++L +A Q+ Q RE E Q +E + Q+ R + E L
Sbjct: 1392 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1451
Query: 110 EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLL-------GELQESQSRLE- 161
+ + + + R+ E +R + ++ E+ V+ Q+ + GELQ ++R E
Sbjct: 1452 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1511
Query: 162 ------AATKECQALEGRARAASEQARQLESE---------REALQQQHSVQ-VDQLRMQ 205
A +E + L + + S++ RQ E E A ++Q ++Q +++LR+Q
Sbjct: 1512 AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1571
Query: 206 GQSVEAALR---MER----QAASEEKRKLAQLQV-AYHQLFQEYDNHIKSSVVGSERKRG 257
+ E LR +ER Q A E ++ A+ ++ + F E ++ S+
Sbjct: 1572 AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA 1631
Query: 258 MQLEDLKQQLQQAEEALVAKQEVIDKLK------EEAEQHKIVMETVPVLK--AQADIYK 309
E+ +++ QQ EA A++E +L+ EA + ++ E V K AQA+ K
Sbjct: 1632 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1691
Query: 310 ADFQAERQAR------EKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKR 359
+AER+AR E+ ++EL +++LE+ QR+ ++ A + +A E +R R
Sbjct: 1692 QKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQELIRLR 1746
Score = 50.4 bits (119), Expect = 3e-06
Identities = 93/390 (23%), Positives = 157/390 (40%), Gaps = 70/390 (17%)
Query: 3 RHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELR 62
R L + +L + + + + L E + M L + + E R E + R
Sbjct: 1756 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1815
Query: 63 DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEA---RKLVERLGLEKLD------ 113
+ RE EE +A E K ++A R ER+ EKL
Sbjct: 1816 --LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1873
Query: 114 -LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEG 172
LK + E AL+E E +++AED+A + + L+E ++ +A +E A
Sbjct: 1874 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRR-------LEEQAAQHKADIEERLA--- 1923
Query: 173 RARAASEQARQLESER------EALQQQHSVQVDQLRMQGQSVEAA-------------- 212
+ R AS+ E ER + L+Q+ V+ + L ++ +AA
Sbjct: 1924 QLRKASDS----ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1979
Query: 213 ------LRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSE---RKRGMQLEDL 263
LR + QA E R+ QL + +E + ++ S+ E R+R LE++
Sbjct: 1980 SNAEDTLRSKEQAELEAARQ-RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2038
Query: 264 KQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLA 323
E L AK E +L+E AEQ E+ L+ + + QAE +A
Sbjct: 2039 --------ERLKAKVEEARRLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAV 2085
Query: 324 EKKEL-LQEQLEQLQREYSKLKASCQESAR 352
++KE LQ+ L+Q Q +L+ + + R
Sbjct: 2086 QQKEQELQQTLQQEQSVLDQLRGEAEAARR 2115
Score = 43.9 bits (102), Expect = 3e-04
Identities = 57/268 (21%), Positives = 116/268 (43%), Gaps = 16/268 (5%)
Query: 87 REEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQV 146
R E E + K ++ R L + LEKL + + E + R ++ ++ +V A
Sbjct: 1091 RSELELTLGKLEQVRSL-SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT- 1148
Query: 147 TSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQH---SVQVDQLR 203
L EL+ +++ L+ + +A + A ++ R + E LQQ+H V+V++ R
Sbjct: 1149 ---LPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1205
Query: 204 MQ-GQSVE--AALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL 260
+ Q +E A+ + E +L + Y + ++ + E+ + M L
Sbjct: 1206 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1265
Query: 261 ED---LKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQ--AE 315
D +++QL+Q + L + +K++E K + + + Q YKA + A
Sbjct: 1266 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1325
Query: 316 RQAREKLAEKKELLQEQLEQLQREYSKL 343
+ K+ E + ++ L+ YS+L
Sbjct: 1326 PAKKPKVQSGSESVIQEYVDLRTHYSEL 1353
Score = 34.3 bits (77), Expect = 0.22
Identities = 51/252 (20%), Positives = 113/252 (44%), Gaps = 31/252 (12%)
Query: 38 MLHLPSEQGAPETLQRCLEENQEL-------RDAIRQSNQILRE---RCEELLHFQASQ- 86
+L L SE+ ++ L+E Q L +D++ Q + + + + E+L + ++
Sbjct: 2495 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2554
Query: 87 ---REEKEFLMCKF-QEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASV 142
REE++ + QE ++LV + + +E R+ E L++ +QQ + + +
Sbjct: 2555 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2614
Query: 143 KAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREAL-------QQQH 195
+ L +LQ + + AA + + AA+ + L + R+AL + +H
Sbjct: 2615 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT---KTLPNGRDALDGPAAEAEPEH 2671
Query: 196 SVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 255
S + ++ Q ++ A + ++EE ++LAQ +L + D ++ + G
Sbjct: 2672 SFDGLRRKVSAQRLQEAGIL----SAEELQRLAQGHTTVDELARRED--VRHYLQGRSSI 2725
Query: 256 RGMQLEDLKQQL 267
G+ L+ ++L
Sbjct: 2726 AGLLLKATNEKL 2737
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 75.1 bits (183), Expect = 1e-13
Identities = 88/358 (24%), Positives = 153/358 (42%), Gaps = 39/358 (10%)
Query: 59 QELRDAIRQSNQILRERCEELLHFQASQREEK---EFLMCKFQEARKLVERLGLEKLDLK 115
Q+L A + LRER L +A ++E+ E L + Q A + + +
Sbjct: 583 QQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQ 642
Query: 116 RQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRAR 175
R+K + R+VE L+ C + +++ +AQV L ELQ + +A KE
Sbjct: 643 REKAELSRKVEELQACVETARQEQHEAQAQVAEL--ELQLRSEQQKATEKE--------- 691
Query: 176 AASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYH 235
++ E++ LQ+Q + L++ S+E R A E++R +++L+
Sbjct: 692 -------RVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETR 744
Query: 236 QLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEE--AEQHKI 293
L +++ K E + G + L+ +LQQ EA A+ EV+ + E A QH
Sbjct: 745 SLVEQHKRERKEL---EEERAGR--KGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTA 799
Query: 294 VMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARI 353
E ++K A A + ++++ A+ + QEQL L+ E K + QE+
Sbjct: 800 ESECEQLVKEVA----AWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEK 855
Query: 354 EDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQ 411
+ H E+ + A L + LA Q+ E + Q A D+ TLQ
Sbjct: 856 VAGIESHSELQISRQQNELAELHANLARALQQVQEKE-------VRAQKLADDLSTLQ 906
Score = 64.3 bits (155), Expect = 2e-10
Identities = 75/356 (21%), Positives = 147/356 (41%), Gaps = 57/356 (16%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL------ 109
E L ++ + IL ++L + +E K +M + ++++KL ERL L
Sbjct: 1221 ERKNSLISSLEEEVSILNR---QVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETA 1277
Query: 110 -------EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGE---------- 152
E+ R++ Q+LRE +R + + + +A+ LG+
Sbjct: 1278 SNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFF 1337
Query: 153 -LQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEA 211
+++ S L+ QAL A +QL++E+ A +++H +++Q + + A
Sbjct: 1338 QKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRA 1397
Query: 212 ALRME----------RQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRG---- 257
L RQ +E++R QL+ ++ K+ + +E RG
Sbjct: 1398 ELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGER 1457
Query: 258 --MQLEDLKQQLQQAEEALV-----AKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKA 310
+ + L+ +L QA E V + + +L E + + + V+ A+ + K
Sbjct: 1458 ANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKV 1517
Query: 311 DFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQA 366
ERQ ++ +K EQLE QRE +K ++E++ K+ + QA
Sbjct: 1518 KVLEERQRFQEERQKLTAQVEQLEVFQREQTK---------QVEELSKKLADSDQA 1564
Score = 62.4 bits (150), Expect = 7e-10
Identities = 106/384 (27%), Positives = 168/384 (43%), Gaps = 65/384 (16%)
Query: 43 SEQGAPETLQRCLEENQELRD-AIRQSNQILRERCEELLHFQASQREEKEF-------LM 94
+ Q E L+R L E + A + Q+++E ++ SQ+EE ++ LM
Sbjct: 777 AHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLM 836
Query: 95 CKFQEARKLVERL--------GLE---KLDLKRQKEQALREVEHLKRCQQQMAEDKASVK 143
+E K + L G+E +L + RQ+ + +L R QQ+ E + V+
Sbjct: 837 TLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKE--VR 894
Query: 144 AQVTSLLGELQESQSRLEAATKECQALEGRARAASEQ----ARQLESE-REALQQQHSVQ 198
AQ L +L Q ++ A +KE LE R A EQ +R+L E A +Q
Sbjct: 895 AQ--KLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWL 952
Query: 199 VDQLRMQGQSVEAALR-MERQA---ASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSER 254
+Q Q S +AAL+ MER+A +E +R A L + Q QE + V +
Sbjct: 953 EEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQ-QEERGQQEREVARLTQ 1011
Query: 255 KRG-----MQLE-----DLKQQLQQA-----------EEALV-------AKQEVIDKLKE 286
+RG + LE +L+ +LQ A +EAL K + + KL+
Sbjct: 1012 ERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRG 1071
Query: 287 -EAEQHKIVME---TVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSK 342
EA Q K + E TV LK Q + + + A+ + A + E +LE L+ E SK
Sbjct: 1072 LEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSK 1131
Query: 343 LKASCQESARIEDMRKRHVEVSQA 366
L+ CQ+ D +R +E +A
Sbjct: 1132 LEQQCQKQQEQADSLERSLEAERA 1155
Score = 56.2 bits (134), Expect = 5e-08
Identities = 73/303 (24%), Positives = 138/303 (45%), Gaps = 47/303 (15%)
Query: 62 RDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQA 121
R+ + QS Q ELL +QRE E + + + A + ER + L+ +K
Sbjct: 1382 REELEQSKQAAGGLRAELLR---AQRELGELIPLRQKVAEQ--ERTAQQ---LRAEKASY 1433
Query: 122 LREVEHLKRCQQQMAEDKASV--KAQVTSLLGELQESQSRLEAATKECQALEGRARAASE 179
++ LK+ +AE+ + +A + E++ Q+R E +E A+ A
Sbjct: 1434 AEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAR-EKYVQELAAVR-----ADA 1487
Query: 180 QARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQ 239
+ R E +REA ++V + +G V+ ERQ EE++KL QV ++FQ
Sbjct: 1488 ETRLAEVQREAQSTARELEVMTAKYEGAKVKVL--EERQRFQEERQKLTA-QVEQLEVFQ 1544
Query: 240 EYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLK----EEAEQHKIVM 295
R++ Q+E+L ++L +++A +Q+ + ++ E ++ + +
Sbjct: 1545 --------------REQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQ 1590
Query: 296 ETVPVLKAQ-------ADIYKADFQAERQAREKLAEKKELLQEQ---LEQLQREYSKLKA 345
+ L+AQ A+ YK + + + ++ + LQEQ LEQLQ+E +L+A
Sbjct: 1591 AQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRA 1650
Query: 346 SCQ 348
+
Sbjct: 1651 EAE 1653
Score = 55.8 bits (133), Expect = 7e-08
Identities = 92/379 (24%), Positives = 150/379 (39%), Gaps = 74/379 (19%)
Query: 52 QRCLEENQELRDAIRQ--------SNQILRERCEELLHFQASQREEKEFLMCKFQEARKL 103
+ C + QEL++A + QI R++ EL A+ + + K A+KL
Sbjct: 840 EECEKARQELQEAKEKVAGIESHSELQISRQQ-NELAELHANLARALQQVQEKEVRAQKL 898
Query: 104 VERLG-LEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGE-----LQESQ 157
+ L L++ KE A E K +QQ + VK + G+ L+E Q
Sbjct: 899 ADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARA--GDRQPEWLEEQQ 956
Query: 158 SRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSV-------- 209
R +T+ AL+ R A + +LE R AL + Q ++ Q + V
Sbjct: 957 GRQFCSTQA--ALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERG 1014
Query: 210 --------EAALRME-----RQAASEEKRKLAQLQVAYHQLFQEYDNHIK--SSVVGSER 254
E A R E + A +E++ + A LQ A E + + + + G E
Sbjct: 1015 RAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEA 1074
Query: 255 KRGMQLEDLKQQLQQAEEALVAKQ-EVIDKLKEEAEQHKIVMETVPVLKA---------- 303
+ +LE+L+Q ++Q +E L K+ E ++E T P L+A
Sbjct: 1075 AQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQ 1134
Query: 304 -------QADIYKADFQAERQAREKLAEKKELLQEQLEQ--------------LQREYSK 342
QAD + +AER +R + E LQ QLE+ QRE +
Sbjct: 1135 QCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAA 1194
Query: 343 LKASCQESARIEDMRKRHV 361
+ Q+ ++ ED K V
Sbjct: 1195 FRTKVQDHSKAEDEWKAQV 1213
Score = 55.5 bits (132), Expect = 9e-08
Identities = 69/326 (21%), Positives = 133/326 (40%), Gaps = 52/326 (15%)
Query: 44 EQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKL 103
EQ + R + L + N ++++ +EL + +E++ L Q+ +
Sbjct: 486 EQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQA 545
Query: 104 VERLGLEKLDLK---RQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRL 160
+ L + L +QKEQ L+EV + +Q D A Q+ + E + S
Sbjct: 546 SQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQ---DHAQ---QLATAAEEREASLRER 599
Query: 161 EAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAA 220
+AA K+ +ALE E+A +LE ++ LQ + + S + ++ ++
Sbjct: 600 DAALKQLEALE------KEKAAKLEILQQQLQVANEAR--------DSAQTSVTQAQREK 645
Query: 221 SEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEV 280
+E RK+ +LQ QE + + Q+ +L+ QL+ ++ K+ V
Sbjct: 646 AELSRKVEELQACVETARQE------------QHEAQAQVAELELQLRSEQQKATEKERV 693
Query: 281 IDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREY 340
+ + EQ + + E++ V K L E+K + LE+ QR
Sbjct: 694 AQEKDQLQEQLQALKESLKVTKG-----------------SLEEEKRRAADALEEQQRCI 736
Query: 341 SKLKASCQESARIEDMRKRHVEVSQA 366
S+LKA + ++ +E +A
Sbjct: 737 SELKAETRSLVEQHKRERKELEEERA 762
Score = 51.6 bits (122), Expect = 1e-06
Identities = 77/334 (23%), Positives = 136/334 (40%), Gaps = 37/334 (11%)
Query: 59 QELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQK 118
Q+L+DA+ + + + +E L QA +E L Q+ +K +E EK ++ + K
Sbjct: 335 QQLQDALNELTEEHSKATQEWLEKQAQLEKE---LSAALQD-KKCLE----EKNEILQGK 386
Query: 119 EQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQA-LEGRARAA 177
L E HL + Q ++K V V L L++ + L A + QA +E
Sbjct: 387 LSQLEE--HLSQLQDNPPQEKGEVLGDVLQL-ETLKQEAATLAANNTQLQARVEMLETER 443
Query: 178 SEQARQLESER----EALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVA 233
+Q +L +ER E QQ S+ D +A +E+ + + R AQ+
Sbjct: 444 GQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASL 503
Query: 234 YHQL------FQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEE 287
+L Q+ D + ++ K+ + L+QQ Q ++ +++ LK++
Sbjct: 504 TSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQK 563
Query: 288 AEQHKIVMETVPVLKAQADIYKADFQAERQA---------------REKLAEKKELLQEQ 332
+Q K V E + A ER+A ++ A K E+LQ+Q
Sbjct: 564 EQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQ 623
Query: 333 LEQLQREYSKLKASCQESARIEDMRKRHVEVSQA 366
L+ + S ++ R + R VE QA
Sbjct: 624 LQVANEARDSAQTSVTQAQREKAELSRKVEELQA 657
Score = 48.1 bits (113), Expect = 1e-05
Identities = 84/375 (22%), Positives = 153/375 (40%), Gaps = 52/375 (13%)
Query: 17 SGGPAADQ-DVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILRER 75
SG PA+ D+L + L E+ + L+ L EN++L ++++R
Sbjct: 198 SGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQR 257
Query: 76 CEELLHFQ----ASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRC 131
+ L AS E KE +E R E L + + +Q + E + R
Sbjct: 258 IDRLALLNEKQAASPLEPKEL-----EELRDKNESLTMRLHETLKQCQDLKTEKSQMDRK 312
Query: 132 QQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ-----------ALEGRARAASEQ 180
Q++E+ + ++ LQ+ Q L T+E LE AA +
Sbjct: 313 INQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQD 372
Query: 181 ARQLESEREALQ------QQH--SVQVDQLRMQGQSVEAALRME--RQAASEEKRKLAQL 230
+ LE + E LQ ++H +Q + + +G+ + L++E +Q A+ QL
Sbjct: 373 KKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQL 432
Query: 231 QVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQ 290
Q L E + + + + +ER E+ KQQL L + + + KEE EQ
Sbjct: 433 QARVEML--ETERGQQEAKLLAERG---HFEEEKQQLSSLITDLQSSISNLSQAKEELEQ 487
Query: 291 ----------HKIVMETVPVLKAQADIYKADFQ---AERQAREKLAEKKELLQEQ---LE 334
++ T + A I + D + ++QA+EK A+ + LQ+Q +
Sbjct: 488 ASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQ 547
Query: 335 QLQREYSKLKASCQE 349
L+ + +L +S ++
Sbjct: 548 GLRHQVEQLSSSLKQ 562
Score = 42.7 bits (99), Expect = 6e-04
Identities = 77/349 (22%), Positives = 146/349 (41%), Gaps = 34/349 (9%)
Query: 6 WKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAI 65
+ QL + + G A + LGE + LG+ L + +Q + +Q + +
Sbjct: 1433 YAEQLSMLKKAHGLLAEENRGLGERANLGRQ-FLEVELDQAREKYVQELAAVRADAETRL 1491
Query: 66 RQSNQILRERCEELLHFQASQREEKEFLM---CKFQEARKL----VERLGLEKLDLKRQK 118
+ + + EL A K ++ +FQE R+ VE+L + + + +Q
Sbjct: 1492 AEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQV 1551
Query: 119 EQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQA-LEGRARAA 177
E+ +++ + + + +V+AQ GE Q+ RL+A E QA L + +AA
Sbjct: 1552 EELSKKLADSDQASKVQQQKLKAVQAQG----GESQQEAQRLQAQLNELQAQLSQKEQAA 1607
Query: 178 SEQARQLESER---EALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVA- 233
Q+E + +A +QQ+ +QLR S+E + ++ +E +R +LQ A
Sbjct: 1608 EHYKLQMEKAKTHYDAKKQQNQELQEQLR----SLEQLQKENKELRAEAERLGHELQQAG 1663
Query: 234 -YHQLFQEYDNHIKSSVVGSERK---RGMQLEDLKQQLQQAEEALVAKQE--------VI 281
+ ++ H+ + V E + QL DL + Q A +AL +++ I
Sbjct: 1664 LKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL-GKFQVATDALKSREPQAKPQLDLSI 1722
Query: 282 DKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQ 330
D L E+ + T + + Q D + ++L K E L+
Sbjct: 1723 DSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPISQRLPPKVESLE 1771
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 74.7 bits (182), Expect = 1e-13
Identities = 85/370 (22%), Positives = 175/370 (47%), Gaps = 55/370 (14%)
Query: 44 EQGAPETLQRCLEENQEL-RDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARK 102
++ + + L+ LE Q+ R ++ Q N+ + E+ +E +AS++ E+ L ++A +
Sbjct: 692 QEASLQKLREELESQQKAERASLEQKNRQMLEQLKE--EIEASEKSEQAALNAAKEKALQ 749
Query: 103 LVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEA 162
+ E+L+ +R++ A E EH ++ + +A + V+SL ++QE+Q + EA
Sbjct: 750 QLR----EQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEA 805
Query: 163 ATKECQA-LEGRARAAS--------EQARQLESEREALQQQHSVQVDQLRMQGQSVEAAL 213
++C +E R S E + L +R+ ++ +H ++D+++ + Q V A
Sbjct: 806 QLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKA 865
Query: 214 RMERQAASEEKR---------KLAQLQVAYHQLFQ--EYDNHIK-SSVVGSERKRGMQLE 261
R + +A ++R +L +LQ A+ + + + H + + R++ +L+
Sbjct: 866 REQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQ 925
Query: 262 DLKQQLQ---------------QAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQAD 306
DL+ L+ Q E A KQ+++D ++ A + + T L+
Sbjct: 926 DLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQK 985
Query: 307 IYKADFQAERQARE----------KLAEKKELLQEQLEQLQREYSKLKASCQESARIEDM 356
+ Q+ +Q RE KL + +LLQ Q +QLQ+ +S L+A Q+ + +
Sbjct: 986 EHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHL--L 1043
Query: 357 RKRHVEVSQA 366
R+ VE + A
Sbjct: 1044 REVTVEENNA 1053
Score = 70.1 bits (170), Expect = 4e-12
Identities = 70/289 (24%), Positives = 149/289 (51%), Gaps = 24/289 (8%)
Query: 83 QASQREEKEFLMCKFQEARKLVERLGLEK----LDLKRQKEQALREVEHLKRCQQQMAED 138
Q +++++ L K ++ ++L E+L E+ L L +QKEQ+L + +R Q+ + E+
Sbjct: 601 QVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLR--ERLQKAIEEE 658
Query: 139 KASVKAQVTSLLGELQ-ESQSRLEAATKECQALEGRA--RAASEQARQLESEREALQQQH 195
+A ++ + + L L+ + QS +A + +A + + + E Q ++ER +L+Q++
Sbjct: 659 EARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKN 718
Query: 196 SVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 255
++QL+ + +EA+ + E+ A + K K A QL ++ + K +V E++
Sbjct: 719 RQMLEQLK---EEIEASEKSEQAALNAAKEK------ALQQLREQLEGERKEAVATLEKE 769
Query: 256 RGMQLEDLKQQLQQAEEALVAK-QEVIDKL--KEEAEQHKIVMETVPVLKAQADIYKADF 312
+LE L L+ +V+ Q+ I + KEEA+ K + + V Q + A +
Sbjct: 770 HSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQ-VEHRVHQKSYHVAGY 828
Query: 313 QAERQA--REKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKR 359
+ E + REK E + + +L++++ E+ ++ A +E E+ ++R
Sbjct: 829 EHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQR 877
Score = 50.1 bits (118), Expect = 4e-06
Identities = 51/229 (22%), Positives = 113/229 (49%), Gaps = 23/229 (10%)
Query: 133 QQMAEDKASVKAQVTSLLGELQESQSRLEAATKE---------CQALEGRARAASEQARQ 183
+Q++E A++KA ++ L++ Q L + +E CQ E +Q Q
Sbjct: 585 EQLSE--AALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQ 642
Query: 184 -LESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASE--EKRKLAQLQVAYHQLFQE 240
L S RE LQ+ + ++R + + LR + Q++++ E + A+ + + +L +E
Sbjct: 643 SLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREE 702
Query: 241 YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEA-----LVAKQEVIDKLKEEAEQHKIVM 295
++ K+ E+K LE LK++++ +E++ AK++ + +L+E+ E +
Sbjct: 703 LESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGER--K 760
Query: 296 ETVPVLKAQ--ADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSK 342
E V L+ + A++ + E + RE ++ ++ +QE ++ + + K
Sbjct: 761 EAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQK 809
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 74.7 bits (182), Expect = 1e-13
Identities = 74/313 (23%), Positives = 146/313 (46%), Gaps = 22/313 (7%)
Query: 51 LQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLE 110
LQ+ E + L + L + + L + ++ +E + + K + L
Sbjct: 841 LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL--- 897
Query: 111 KLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQAL 170
K L+ Q E L+E + LK+ ++ E +K ++ S+ +L ++Q+ L+ KE Q L
Sbjct: 898 KHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL 957
Query: 171 EGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQL 230
+G + + Q + + EALQ + + V Q ++ L Q + EK K++ L
Sbjct: 958 QGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVL 1017
Query: 231 QVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEAL-VAKQEVIDKLKEEAE 289
Q Y + QE ++S G E +L +Q L+ EE L +A++++I +
Sbjct: 1018 QNNYEK-SQETFKQLQSDFYGRE----SELLATRQDLKSVEEKLSLAQEDLISNRNQIGN 1072
Query: 290 QHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQL---EQLQREYSKLKAS 346
Q+K++ E + A+A + + + E+Q +E+ +++ +E+ ++L E SKL
Sbjct: 1073 QNKLIQE---LKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKL--- 1126
Query: 347 CQESARIEDMRKR 359
A IE+++ R
Sbjct: 1127 ----AEIEEIKCR 1135
Score = 73.6 bits (179), Expect = 3e-13
Identities = 72/342 (21%), Positives = 165/342 (48%), Gaps = 21/342 (6%)
Query: 40 HLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQE 99
HL + Q A + Q+ L + D + Q +E C +L +E+ L K +E
Sbjct: 668 HLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEE 727
Query: 100 ARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSR 159
+++L + L++K KEQAL++++ ++ + + Q+ + ++
Sbjct: 728 LEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLD 787
Query: 160 LEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAAL---RME 216
L+ ++ ++++ + E+ + L+ + E L Q+ +Q ++L + Q+ L +ME
Sbjct: 788 LQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKME 847
Query: 217 RQAASEE----KRKLAQLQVAYHQLFQEYDNHI---KSSVVGSERKRGMQLEDLKQQLQ- 268
++A E K KL+++ + E++ K++++ E+ ++LK QLQ
Sbjct: 848 KEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK----TCKELKHQLQV 903
Query: 269 QAEEALVAKQEV---IDKLKEEAEQHKIVMETVPVLKAQA-DIYKADFQAERQAREKLAE 324
Q E L ++E+ ++K KE + Q K+ + ++ QA + K + + E+Q + + E
Sbjct: 904 QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE 963
Query: 325 KKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQA 366
K+ +++ +Q++ +LK + + +E+ K +++QA
Sbjct: 964 LKQSSEQKKKQIEALQGELKIAVLQKTELEN--KLQQQLTQA 1003
Score = 60.5 bits (145), Expect = 3e-09
Identities = 67/339 (19%), Positives = 160/339 (47%), Gaps = 35/339 (10%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
ET ++ E + L++ + S++ L ++ +++ Q +E L K + +L +L
Sbjct: 425 ETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL- 483
Query: 109 LEKLDLKRQKEQALRE--VEHLKRCQ---QQMAEDKASVKAQVTSLLGELQESQSRLEAA 163
+K + Q++QAL++ L+ Q +Q+ ++ +L LQ+S+ +
Sbjct: 484 -DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLL 542
Query: 164 TKECQALEGRARAASEQA---RQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAA 220
KE + L + +A + QL+ + LQ+Q + ++L+ Q +S + A
Sbjct: 543 EKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV 602
Query: 221 SEEKR-------KLAQLQVAYHQL----------FQEYDNHIKSS---VVGSERKRGMQL 260
E+K ++ L+ + ++L + D IK+ ++ +E + Q
Sbjct: 603 QEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQR 662
Query: 261 EDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQARE 320
DL+ L A+ AL KQ+ ++K+ + +Q ++ +Q + + ++ ++
Sbjct: 663 ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY---KEKYL 719
Query: 321 KLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKR 359
L +K E L+ Q+++L+ + ++KAS +++ ++D++++
Sbjct: 720 SLEQKTEELEGQIKKLEADSLEVKASKEQA--LQDLQQQ 756
Score = 57.0 bits (136), Expect = 3e-08
Identities = 85/365 (23%), Positives = 156/365 (42%), Gaps = 58/365 (15%)
Query: 41 LPSEQGAPET-LQRCLEENQELRDAIRQSNQILRERCEELLHFQAS------QREEKEFL 93
L S A ET L R E E +A ++ + L E + H +A QREEKE
Sbjct: 349 LQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQH 408
Query: 94 MCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGEL 153
+ Q + +L + L+ +RQ L E + Q+Q++ +K K Q + +L
Sbjct: 409 GLQLQSE---INQLHSKLLETERQ----LGEAHGRLKEQRQLSSEKLMDKEQ---QVADL 458
Query: 154 QESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQ--------LRMQ 205
Q SRLE KE + ++ +Q E++ALQQ + ++ + LR
Sbjct: 459 QLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQI 518
Query: 206 G------QSVEAALRMER-----------------QAASEEKRKLAQLQVAYH------- 235
G Q++EA L+ + QA E L QLQ H
Sbjct: 519 GDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVT 578
Query: 236 QLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVM 295
QL ++ N +S E Q+++ K L+ A++ +++ + +++L + + K +
Sbjct: 579 QLTEKLKNQSESHKQAQENLHD-QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKV 637
Query: 296 ETVPV-LKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASC-QESARI 353
+ + +KA+ ++ + A+ R L + Q L+ Q+E +K+ Q +A++
Sbjct: 638 SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKL 697
Query: 354 EDMRK 358
+D ++
Sbjct: 698 QDKQE 702
Score = 54.3 bits (129), Expect = 2e-07
Identities = 76/330 (23%), Positives = 137/330 (41%), Gaps = 31/330 (9%)
Query: 51 LQRCLEENQELRDAI----RQSNQILRERCEELLHFQASQREEKEFLMCKF----QEARK 102
L++ L + Q L D + + ++ L++ C++L AS L + QE
Sbjct: 226 LKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAV 285
Query: 103 LVERLGLEKLDLKR--QKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRL 160
V+ L K + QK Q L E LK+ Q ++ + V+ + Q+ L
Sbjct: 286 YVQELQKLKSSVNELTQKNQTLTE-NLLKKEQDYTKLEEKHNEESVSK-----KNIQATL 339
Query: 161 EAATKECQALEGRARAASEQARQLE---SEREALQQQHSVQVDQLRMQGQSVEAALRMER 217
+CQ L+ R A+ ++ SE+ Q+ ++ ++ + Q ++A + +
Sbjct: 340 HQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQ 399
Query: 218 QAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAK 277
Q E+++ QLQ +QL S ++ +ER+ G LK+Q Q + E L+ K
Sbjct: 400 QQREEKEQHGLQLQSEINQLH--------SKLLETERQLGEAHGRLKEQRQLSSEKLMDK 451
Query: 278 -QEVID---KLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQL 333
Q+V D KL EQ K + L+ Q D K Q ++ ++ K Q L
Sbjct: 452 EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDL 511
Query: 334 EQLQREYSKLKASCQESARIEDMRKRHVEV 363
EQ+ R+ Q + K ++ +
Sbjct: 512 EQVLRQIGDKDQKIQNLEALLQKSKENISL 541
Score = 47.0 bits (110), Expect = 3e-05
Identities = 70/334 (20%), Positives = 162/334 (48%), Gaps = 48/334 (14%)
Query: 60 ELRDAIRQSNQI---LRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKR 116
EL+ A+ Q ++ L+++ + A+++E+ L ++++++ ++L + D
Sbjct: 981 ELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQL---QSDFYG 1037
Query: 117 QKEQALREVEHLKRCQQQMA---EDKASVKAQV---TSLLGELQESQSRLE--AATKE-- 166
++ + L + LK +++++ ED S + Q+ L+ EL+ +++ LE +A KE
Sbjct: 1038 RESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQ 1097
Query: 167 ----CQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAAS- 221
C+AL+ + S + ++L +E+ L ++++++ + + L E ++
Sbjct: 1098 LQERCKALQDIQKEKSLKEKELVNEKSKL-----AEIEEIKCRQEKEITKLNEELKSHKL 1152
Query: 222 EEKRKLAQLQVAYHQLFQE------YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALV 275
E +++ L+ A L Q+ + +K++V + KR Q+ LK Q+++ EE L
Sbjct: 1153 ESIKEITNLKDAKQLLIQQKLELQGKADSLKAAV--EQEKRNQQI--LKDQVKKEEEEL- 1207
Query: 276 AKQEVID---KLKEEAEQHKIVM----ETVPVLKAQADIYKADFQAERQAREKLAEKKEL 328
K+E I+ KL E ++ ++ M E L Q + ++ + +
Sbjct: 1208 -KKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSE 1266
Query: 329 LQEQLEQLQREYSKLKASCQESARIEDMRKRHVE 362
L++Q + L+ E + L+A+ Q + +D R+ +E
Sbjct: 1267 LEKQTDDLRGEIAVLEATVQNN---QDERRALLE 1297
Score = 41.2 bits (95), Expect = 0.002
Identities = 40/168 (23%), Positives = 74/168 (44%), Gaps = 22/168 (13%)
Query: 199 VDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGM 258
V LR + Q ++A+L+ E+ + E K++L + Q Q ++ G
Sbjct: 85 VTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQ---------EAKPDGLVTDSSA 135
Query: 259 QLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQA 318
+L+ L+QQL++A+ +++ D +++A Q L + K+ + ER
Sbjct: 136 ELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQ----------LATEIADIKSKYDEERSL 185
Query: 319 REKLAEKKELLQEQLEQLQREYSKLKASCQESARIED---MRKRHVEV 363
RE +K L E+L + LK + IED ++K V+V
Sbjct: 186 REAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQV 233
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 74.3 bits (181), Expect = 2e-13
Identities = 80/359 (22%), Positives = 163/359 (45%), Gaps = 39/359 (10%)
Query: 23 DQDVLGEESPLGKPAMLHLPSEQGAPE--TLQ-RCLEENQELRDAIRQSNQILRERCEEL 79
+++++ +E L K L +E E TLQ + + E +L++ ++ ++ E E
Sbjct: 844 EEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELR 903
Query: 80 LHFQASQREEKEF---LMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMA 136
A ++E +E L + +E + + L EK +++ ++ ++E + +Q++
Sbjct: 904 ARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQ 963
Query: 137 EDKASVKAQVTSLLGELQESQSRLE----AATKECQALEGRARAASEQARQLESEREAL- 191
+K + +A+ L +L+E Q LE KE + LE R + + E + ++L
Sbjct: 964 LEKVTTEAK----LKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLA 1019
Query: 192 --QQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSV 249
+ +H + L + + E +RQ + +RKL E D+ S
Sbjct: 1020 KLKNKHEAMITDLEERLRREEK----QRQELEKTRRKL------------EGDSTDLSDQ 1063
Query: 250 VGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYK 309
+ + Q+ +LK QL + EE L Q + +++EEA Q + ++ + L++Q +
Sbjct: 1064 IAELQA---QIAELKMQLAKKEEEL---QAALARVEEEAAQKNMALKKIRELESQISELQ 1117
Query: 310 ADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPL 368
D ++ER +R K ++K L E+LE L+ E S + R++ V + + L
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTL 1176
Score = 63.9 bits (154), Expect = 3e-10
Identities = 74/324 (22%), Positives = 141/324 (43%), Gaps = 27/324 (8%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
E L + EE D + ++ L++ ++LL QR+ C ++ +K ++L
Sbjct: 1395 EGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA----CNLEKKQKKFDQLL 1450
Query: 109 LEK--LDLKRQKEQALREVE---------HLKRCQQQMAEDKASVKAQVTSLLGELQESQ 157
E+ + K +E+ E E L R ++ E KA ++ E+++
Sbjct: 1451 AEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLM 1510
Query: 158 SRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVD---QLRMQGQSVEAALR 214
S + K LE RA +Q +++++ E L+ + D +L + Q+++A
Sbjct: 1511 SSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE 1570
Query: 215 ME---RQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAE 271
+ R SEEK+K QV + E + +S V + +K M L+DL+ + A
Sbjct: 1571 RDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSAN 1630
Query: 272 EALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQE 331
+ + E I +L++ Q K M + +A + A QA+ ++ + + E++Q
Sbjct: 1631 K---NRDEAIKQLRKLQAQMKDCMRELDDTRASREEILA--QAKENEKKLKSMEAEMIQL 1685
Query: 332 QLEQLQREYSKLKASCQESARIED 355
Q E E +K +A QE + D
Sbjct: 1686 QEELAAAERAKRQAQ-QERDELAD 1708
Score = 62.8 bits (151), Expect = 6e-10
Identities = 82/351 (23%), Positives = 151/351 (43%), Gaps = 53/351 (15%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
E L+R ++ QEL R+ + +++ QA E K L K +E + + R+
Sbjct: 1034 ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVE 1093
Query: 109 LEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQ------------------VTSLL 150
E QK AL+++ L+ ++ ED S +A T L
Sbjct: 1094 EEAA----QKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELE 1149
Query: 151 GELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLR---MQGQ 207
L + ++ E +K Q + + E+A+ E++ + ++Q+HS V++L Q +
Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK 1209
Query: 208 SVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVG---SERKRGMQLEDLK 264
V+A L +Q E+ +LA N +K + G SE KR + ++
Sbjct: 1210 RVKANLEKAKQTLENERGELA--------------NEVKVLLQGKGDSEHKR----KKVE 1251
Query: 265 QQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQARE-KLA 323
QLQ+ + + V +L ++ + ++ ++ V L +Q+D + + A E +L
Sbjct: 1252 AQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQ 1311
Query: 324 EKKELLQEQLEQLQREYSKLKA------SCQESARIEDMRKRHVEVSQAPL 368
+ +ELLQE+ Q +KLK S +E E+ K ++E A L
Sbjct: 1312 DTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL 1362
Score = 60.5 bits (145), Expect = 3e-09
Identities = 71/336 (21%), Positives = 144/336 (42%), Gaps = 38/336 (11%)
Query: 51 LQRCLEEN--------QELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARK 102
L++ LEE QE+R Q+ + L E+ E+ +A+ + K+ L + E
Sbjct: 1172 LKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELAN 1231
Query: 103 LVERLGLEKLDLKRQKEQALREVEHLK-------RCQQQMAEDKASVKAQVTSLLGELQE 155
V+ L K D + ++++ +++ L+ R + ++A+ ++ ++ ++ G L +
Sbjct: 1232 EVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQ 1291
Query: 156 SQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRM 215
S S+ TK+ ALE + + E ++ ++ +L S ++ Q+ + S L
Sbjct: 1292 SDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL----STKLKQVEDEKNSFREQLEE 1347
Query: 216 ERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALV 275
E +A ++++A L + ++ ++ + E KR +Q +DL + L Q E V
Sbjct: 1348 EEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ-KDL-EGLSQRHEEKV 1405
Query: 276 AKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQ 335
A + ++K K +Q + D D +RQ+ L +K Q++ +Q
Sbjct: 1406 AAYDKLEKTKTRLQQ-------------ELDDLLVDLDHQRQSACNLEKK----QKKFDQ 1448
Query: 336 LQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPA 371
L E + A E + R E L A
Sbjct: 1449 LLAEEKTISAKYAEERDRAEAEAREKETKALSLARA 1484
Score = 55.8 bits (133), Expect = 7e-08
Identities = 62/304 (20%), Positives = 125/304 (41%), Gaps = 32/304 (10%)
Query: 58 NQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQ 117
N+ +AI+Q + L+ + ++ + R +E ++ + +E K ++ + E + L+ +
Sbjct: 1630 NKNRDEAIKQLRK-LQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEE 1688
Query: 118 KEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAA 177
L E KR QQ ++ A E+ S + A +E + LE R
Sbjct: 1689 ----LAAAERAKRQAQQERDELAD----------EIANSSGKGALALEEKRRLEARIAQL 1734
Query: 178 SEQARQLESEREALQ---QQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAY 234
E+ + + E + ++ ++Q+DQ+ + + A + +R+ +L+V
Sbjct: 1735 EEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKL 1794
Query: 235 HQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKE-------- 286
++ + K+S+ E K E L + ++ + A + KLK+
Sbjct: 1795 QEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE 1854
Query: 287 --EAEQHKIVMETVPV----LKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREY 340
AEQ+K + LK Q + + + Q +R KL + E E + + RE
Sbjct: 1855 RRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREV 1914
Query: 341 SKLK 344
S LK
Sbjct: 1915 SSLK 1918
Score = 29.3 bits (64), Expect = 7.0
Identities = 30/154 (19%), Positives = 66/154 (42%), Gaps = 21/154 (13%)
Query: 40 HLPSEQGAPETLQRCLEENQELRDAIRQ-----------SNQILRERCEELLHFQASQRE 88
H + A + L+R +N+EL+ +++ S L + +L ++ +
Sbjct: 1772 HAQKNENARQQLER---QNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETK 1828
Query: 89 EKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ-------ALREVEHLKRCQQQMAEDKAS 141
E++ + + K ++ + L+ D +R EQ A ++ LKR ++ E+
Sbjct: 1829 ERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQR 1888
Query: 142 VKAQVTSLLGELQESQSRLEAATKECQALEGRAR 175
A L EL+++ +A +E +L+ + R
Sbjct: 1889 ANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922
>gi|21450705 leucine rich repeat containing 45 [Homo sapiens]
Length = 670
Score = 72.8 bits (177), Expect = 5e-13
Identities = 91/352 (25%), Positives = 162/352 (46%), Gaps = 64/352 (18%)
Query: 85 SQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALR----EVEHLKRCQQQMAEDKA 140
SQR+ KE L + QEA + +L L L +K L+ E+E RCQQ E
Sbjct: 337 SQRQAKE-LKLEQQEAAERESKL-LRDLSAANEKNLLLQNQVDELERKFRCQQ---EQLF 391
Query: 141 SVKAQVTSLLGELQ----ESQSRLEAATKECQA-------------------LEGRARAA 177
+ ++TS+ EL+ +++ RL+ + C+ LE +A
Sbjct: 392 QTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAM 451
Query: 178 SEQARQLESEREALQQQHS-VQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQ 236
E+ ++LE+ R +L+++ S V+ L +GQ+ E ++ + QA EE+++LA L+
Sbjct: 452 QERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRL 511
Query: 237 LFQEYDNH-----IKSSVVGSERKR----GMQLEDLKQQLQQAEEALVAKQEVIDKLKEE 287
L Q D + VV + R G+Q+E L+++L++ ++ L K + +
Sbjct: 512 LAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQ-----ERV 566
Query: 288 AEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSK--LKA 345
AE ++ +E L+ Q QAE A+E L EK L+ QL+ + ++ + L
Sbjct: 567 AEVSRVRVE----LQEQ----NGRLQAELAAQEALREKAAALERQLKVMASDHREALLDR 618
Query: 346 SCQESARIEDMRKRHVEVSQAPLPPAP-------AYLSSPLALPSQRRSPPE 390
+ ++ E +R R E+++ A A L+ A P + SPP+
Sbjct: 619 ESENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQASPVRTLSPPK 670
Score = 56.6 bits (135), Expect = 4e-08
Identities = 74/273 (27%), Positives = 119/273 (43%), Gaps = 36/273 (13%)
Query: 97 FQEARKLVERLGLEKLDLKRQK-EQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQE 155
FQE + L E L+ +K +Q L +E + + +++MA+ + A+V L L E
Sbjct: 234 FQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNE 293
Query: 156 SQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRM 215
S + A + Q E A A SEQ Q E A +Q + + Q + + +E
Sbjct: 294 RHSIINALKAKLQMTEA-ALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAA 352
Query: 216 ERQ-------AASEEKRKLAQLQV---------AYHQLFQ------EYDNHIKSSVVGSE 253
ER+ +A+ EK L Q QV QLFQ +K + +E
Sbjct: 353 ERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAE 412
Query: 254 RKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKA-------QAD 306
+ M+ +Q L+ +E + + E + + EE+E K + E V L+A +
Sbjct: 413 ERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESE--KAMQERVQRLEAARLSLEEELS 470
Query: 307 IYKADFQAER-QAREKLAEKKELLQEQLEQLQR 338
KA +ER QA E+L + K Q +LE+ QR
Sbjct: 471 RVKAAALSERGQAEEELIKAKS--QARLEEQQR 501
Score = 45.8 bits (107), Expect = 7e-05
Identities = 63/229 (27%), Positives = 98/229 (42%), Gaps = 28/229 (12%)
Query: 1 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE 60
M RHL +S+ + AA L EE K A L SE+G E EE +
Sbjct: 440 MTRHLEESEKAMQERVQRLEAARLS-LEEELSRVKAAAL---SERGQAE------EELIK 489
Query: 61 LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQ----EARKLVERLGLEKLDLKR 116
+ R Q E+ L A R+E + + + EA+ V +LGL+ L+R
Sbjct: 490 AKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRR 549
Query: 117 QKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARA 176
+ E+ QQ+++ A+V+ + ELQE RL+A +AL +A A
Sbjct: 550 RLEEL----------QQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAA 599
Query: 177 ASEQARQLESE-REALQQQHSVQV---DQLRMQGQSVEAALRMERQAAS 221
Q + + S+ REAL + S ++LR++ + E Q AS
Sbjct: 600 LERQLKVMASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRAS 648
Score = 32.3 bits (72), Expect = 0.82
Identities = 54/249 (21%), Positives = 91/249 (36%), Gaps = 47/249 (18%)
Query: 201 QLRMQGQSVEA-ALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSE-----R 254
+L + G ++ LR QA + +L Q +N ++ V+ E
Sbjct: 204 RLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQ----------ENQARTHVLSKEVQHLRE 253
Query: 255 KRGMQLEDLKQQLQQAEEALVAKQEV----IDKLKEEA-EQHKIVMETVPVLKAQADIYK 309
++ Q DL + + + E + + +L+E E+H I+ LKA+ + +
Sbjct: 254 EKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIIN----ALKAKLQMTE 309
Query: 310 ADFQAERQAREKLAEKKELL-QEQLEQLQREYSKLKASCQESARIE-------------- 354
A Q + L E QEQL QR+ +LK QE+A E
Sbjct: 310 AALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKN 369
Query: 355 -------DMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDM 407
D +R Q L ++S A R EE D +C+ D
Sbjct: 370 LLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDS 429
Query: 408 DTLQIHVME 416
++L+I +E
Sbjct: 430 ESLRIKEVE 438
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 71.6 bits (174), Expect = 1e-12
Identities = 84/369 (22%), Positives = 167/369 (45%), Gaps = 47/369 (12%)
Query: 44 EQGAPETLQRCLEENQELRDAIRQSNQIL---RERCEELLHFQASQREEKEFLMCKFQEA 100
+Q + L++C + L A+++ Q L RE+ EL + +QR E + + ++
Sbjct: 1475 QQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKK 1534
Query: 101 RKLVERLGLEKLDLKRQKEQA------LREVEHLKRCQQQMAED----KASVKAQVTSLL 150
+++E + DLK+Q L E H CQQ++ ++ + + + +T L
Sbjct: 1535 DQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLT 1594
Query: 151 GELQESQSRLEAATKECQALEGR----ARAASEQARQLESEREALQ-------------- 192
+L+E L+A + + LE AR E+ ++++S+RE ++
Sbjct: 1595 LDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLE 1654
Query: 193 --------QQHSVQV--DQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYD 242
Q+ +QV DQ Q + +E L + + E R+L + + +E
Sbjct: 1655 RRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGK 1714
Query: 243 NHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAE-QHKIVMETVPVL 301
K+ GS + L D +++++ +E + QE+ D+L+++ + H+ V ET +L
Sbjct: 1715 GPSKAQR-GSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLL 1773
Query: 302 KAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYS----KLKASCQESARIEDMR 357
+ Q ++ARE+ K++ LQ QL++ QR + +L+A QE + +
Sbjct: 1774 SQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQE 1833
Query: 358 KRHVEVSQA 366
+R E + A
Sbjct: 1834 ERVKEKADA 1842
Score = 66.6 bits (161), Expect = 4e-11
Identities = 93/364 (25%), Positives = 159/364 (43%), Gaps = 62/364 (17%)
Query: 39 LHLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQ 98
L L ++ E Q + E QEL+D + Q Q L + E + + +E L + Q
Sbjct: 1729 LILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQ 1788
Query: 99 EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQS 158
EAR E+ +LK Q Q+ L Q+ +A+ ++A L E Q++Q
Sbjct: 1789 EAR--------EQGELKEQSLQS-----QLDEAQRALAQRDQELEA----LQQEQQQAQG 1831
Query: 159 RLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQV----DQLRMQG---QSVEA 211
+ E ++ AL+G A EQA ER Q H Q ++L ++G Q++E
Sbjct: 1832 QEERVKEKADALQG----ALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEE 1887
Query: 212 ALRMERQAASEEKRKLAQLQVAYHQLFQEY--------DNHIKSSVVGSERKRGMQLEDL 263
L R + E+++ L LQ + QE+ D+ +++ V ER + +LE L
Sbjct: 1888 VLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQ--ELEAL 1945
Query: 264 KQQLQQA---EEALVAKQEVIDK---------------LKEEAEQHKIVMETVPVLKAQA 305
+ + Q + EEA A+ E + + L E+AE + + + L+A
Sbjct: 1946 RAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASL 2005
Query: 306 DIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLK---ASCQESARIEDMRKRHVE 362
D +A RQ E L ++ +Q+Q + Q + +L+ A E R + R++ +E
Sbjct: 2006 DACQAH---SRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLE 2062
Query: 363 VSQA 366
S A
Sbjct: 2063 KSLA 2066
Score = 65.9 bits (159), Expect = 7e-11
Identities = 86/358 (24%), Positives = 152/358 (42%), Gaps = 41/358 (11%)
Query: 1 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPET----LQRCLE 56
+++ LWK+Q +DVL ++ + + +E+ T LQR L
Sbjct: 1248 LHQDLWKTQ------------QTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLS 1295
Query: 57 ENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKR 116
+NQE + L EL AS + + EA+ E+ L+
Sbjct: 1296 QNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQG-------ERELLQA 1348
Query: 117 QKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGE-LQESQSRLEAATKECQALEGRAR 175
KE +VEHL Q A +A +A +L E L+ ++S L+ +E ++ RA+
Sbjct: 1349 AKENLTAQVEHL-----QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQ 1403
Query: 176 AASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASE----EKRKLAQLQ 231
A EQ ++ +ALQ+ ++ L + + VE LR + Q + +K L L
Sbjct: 1404 ALQEQGELKVAQGKALQENLALLTQTLAEREEEVE-TLRGQIQELEKQREMQKAALELLS 1462
Query: 232 VAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQH 291
+ + QE D ++ + K LE L +Q+ E+ L ++E I +L+++ E
Sbjct: 1463 LDLKKRNQEVD--LQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQ 1520
Query: 292 KIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQE 349
+ V+E ++ K D E Q + KK+L+ + L+ E + K CQ+
Sbjct: 1521 RNVLE-----HQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQ 1573
Score = 61.6 bits (148), Expect = 1e-09
Identities = 77/312 (24%), Positives = 139/312 (44%), Gaps = 36/312 (11%)
Query: 72 LRERCEELLHFQASQREEK---EFLMCKFQ-EARKLVERLGLEKLDLKRQKEQALREVEH 127
L+E+ E+ QA + EE+ E +C+ Q E K ER+ L + L+ QKE A +
Sbjct: 891 LKEQQTEMEAIQAQREEERTQAESALCQMQLETEK--ERVSLLETLLQTQKELADAS-QQ 947
Query: 128 LKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATK----ECQALEGRARAASEQARQ 183
L+R +Q M K + L +LQE+Q L+ A + + AL+ + + +
Sbjct: 948 LERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMD 1007
Query: 184 LESEREALQQQHSVQVDQLRMQGQSVEAALR-----------MERQAAS------EEKRK 226
L+ + E L+ Q Q D R+ Q V+ LR +ER+ AS E++++
Sbjct: 1008 LQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQR 1067
Query: 227 LAQLQVAYHQLFQEYD--NHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQ-EVIDK 283
L LQ A QE G +++ Q+E L+Q++++ E +A++ +++++
Sbjct: 1068 LLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEE 1127
Query: 284 LK-----EEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQR 338
L+ E+ + + + + Q + + Q E A E+ + Q QL L
Sbjct: 1128 LEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYS 1187
Query: 339 EYSKLKASCQES 350
+ S ES
Sbjct: 1188 ALQQALGSVCES 1199
Score = 60.1 bits (144), Expect = 4e-09
Identities = 87/354 (24%), Positives = 150/354 (42%), Gaps = 59/354 (16%)
Query: 41 LPSEQGAPETLQRCLEENQELRDAIRQSNQILR---ERCEEL-LHFQASQR---EEKEFL 93
+ + + A LQ L E ++ R+A+ + N L ++ EE QA R EEKE +
Sbjct: 633 MEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI 692
Query: 94 MCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGEL 153
K E+R Q+E A ++E L + ++ E A + +L+ E
Sbjct: 693 QKKLSESR--------------HQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREK 738
Query: 154 QESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHS---VQVDQLRMQGQSVE 210
+ RL+A ++ Q L + + S LES QQQ+S V QL +Q Q+V
Sbjct: 739 AALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVT 798
Query: 211 AA--------------LRMERQAASEEK----RKLAQLQ----VAYHQLFQEYDNHIKSS 248
A L ER A +E+ R+LAQ + A Q ++ +
Sbjct: 799 QAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQL 858
Query: 249 VVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIY 308
E++R ++L + L+ E K E+ +LKE+ + + + + QA+
Sbjct: 859 REKWEKERSWHQQELAKALESLER---EKMELEMRLKEQQTEMEAIQAQREEERTQAESA 915
Query: 309 KADFQAERQAREKLAEKKELLQ---------EQLEQLQREYSKLKASCQESARI 353
Q E + +E+++ + LLQ +QLE+L+++ K QE+ I
Sbjct: 916 LCQMQLETE-KERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI 968
Score = 60.1 bits (144), Expect = 4e-09
Identities = 79/357 (22%), Positives = 143/357 (40%), Gaps = 51/357 (14%)
Query: 21 AADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELL 80
A+ +L E+ + A+ E + + L+E EL+ A + L+E L
Sbjct: 1371 ASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVA---QGKALQENLALLT 1427
Query: 81 HFQASQREEKEFLMCKFQEARKLVER----LGLEKLDLKRQKEQALREVEHLKRCQQQMA 136
A + EE E L + QE K E L L LDLK++ ++ + E ++
Sbjct: 1428 QTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ------- 1480
Query: 137 EDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHS 196
EL++ +S LE Q E + EQ R+LE +RE +
Sbjct: 1481 ---------------ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLE 1525
Query: 197 VQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQ-----EYDNHIKSSVVG 251
Q+ +L + Q +E+ +R + K++L L+ +L + E + + G
Sbjct: 1526 HQLLELEKKDQMIES----QRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEG 1581
Query: 252 SERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKAD 311
+ + L L L++ + L A+ I L+ + VL + +
Sbjct: 1582 QRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHS----------TVLARELQERDQE 1631
Query: 312 FQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPL 368
+++R+ E+L +KE L + LE+ +E K Q +ED R R ++ + L
Sbjct: 1632 VKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQV---LEDQRTRQTKILEEDL 1685
Score = 55.1 bits (131), Expect = 1e-07
Identities = 75/342 (21%), Positives = 141/342 (41%), Gaps = 44/342 (12%)
Query: 44 EQGAPETLQRCLEENQ-ELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARK 102
EQ LQ L+E Q EL++A RQ L A+ +EE L+ + +K
Sbjct: 962 EQETTGILQTQLQEAQRELKEAARQHRDDL-----------AALQEESSSLLQDKMDLQK 1010
Query: 103 LVERLGLEKLD-------LKRQKEQALREVEHLKRCQQQMAEDKASV------KAQVTSL 149
VE L + + ++++ ++ LRE + R Q+++ +KAS+ K Q +
Sbjct: 1011 QVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLV 1070
Query: 150 LGELQE-SQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQS 208
L E Q L A ++ Q +G + S Q L E + + Q QL + ++
Sbjct: 1071 LQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEA 1130
Query: 209 VEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQ 268
+ R + ++ K AQLQ+ + + G++ + QL L LQ
Sbjct: 1131 SHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQ 1190
Query: 269 QAEEALVAKQEVID----------KLKEEAEQHKIVMETVPVLKA------QADIYK--A 310
QA ++ + + L+ + + + + P+L A + ++K
Sbjct: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ 1250
Query: 311 DFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESAR 352
D +Q R+ L ++ + L+E+L + E S++ Q+ R
Sbjct: 1251 DLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQR 1292
Score = 54.3 bits (129), Expect = 2e-07
Identities = 75/345 (21%), Positives = 148/345 (42%), Gaps = 12/345 (3%)
Query: 41 LPSEQGAPETLQRCLEENQELRDAIRQS---NQILRERCEELLHFQASQREEKEFLMCKF 97
L S+ A + QR +E QE+++ +R++ N+I +E E S E+++ L+
Sbjct: 1015 LKSQLVAQDDSQRLVE--QEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLV-L 1071
Query: 98 QEARKLVER-LGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQES 156
QEA + ++ L + D++ + + ++ +Q++ E +A AQ LL EL+ S
Sbjct: 1072 QEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEAS 1131
Query: 157 QSRLEAATKECQALEGRARAASEQARQLESEREAL--QQQHSVQVDQLRMQGQSVEAALR 214
+ A E +A + R ES+ EAL +QQ Q Q + Q S+ +AL+
Sbjct: 1132 HITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQA-QAQAQLASLYSALQ 1190
Query: 215 MERQAASEEKRKLAQLQVAYHQLF--QEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEE 272
+ E + +L+ + ++ + N +S + E + L + +
Sbjct: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ 1250
Query: 273 ALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQ 332
L Q+ D L+++ ++ + + K+Q D Q + ++ K E Q
Sbjct: 1251 DLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNS 1310
Query: 333 LEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSS 377
LE E + AS Q R ++++ + + L A L++
Sbjct: 1311 LESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTA 1355
Score = 53.5 bits (127), Expect = 3e-07
Identities = 66/307 (21%), Positives = 133/307 (43%), Gaps = 19/307 (6%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELL----HFQASQREEKEFLMCKFQEARKLV 104
E LQ+ EE ++ + + Q LR EL Q + E++E L +E +L
Sbjct: 466 ELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQ 525
Query: 105 ERLGLEKLDLKRQKEQALREVEHLKRCQQQM---AEDKASVKAQVTSLLGELQESQSRLE 161
E L + L+ ++ ++L E+ L+ + E + +VT+ L ++S + L
Sbjct: 526 EML----MGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELS 581
Query: 162 AATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAAS 221
++ + RAA+ + L + + Q+ QL + QSV + + QA +
Sbjct: 582 SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641
Query: 222 EEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVI 281
+ LA+ + L+ E + H+++ + +E + G +L+ + +Q+ K+E+
Sbjct: 642 ALQVDLAEAEKRREALW-EKNTHLEAQLQKAE-EAGAELQADLRDIQE------EKEEIQ 693
Query: 282 DKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYS 341
KL E Q + + L +A + Q +E L +K L+ +L+ ++R+
Sbjct: 694 KKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQ 753
Query: 342 KLKASCQ 348
L Q
Sbjct: 754 DLAEQLQ 760
Score = 50.8 bits (120), Expect = 2e-06
Identities = 70/312 (22%), Positives = 127/312 (40%), Gaps = 51/312 (16%)
Query: 49 ETLQRCLEENQELRDAI-----RQSNQI-----LRERCEELLHFQASQREEKEFLMCKFQ 98
E L + E + L++ + +QS + LRE E R+E+ +
Sbjct: 512 EELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALA 571
Query: 99 EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQS 158
A + + L + LK + L + +A DK + Q+ L E Q S
Sbjct: 572 RAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCS 631
Query: 159 RLEAATKECQALEGRARAASEQARQLESEREALQQQHS---VQVDQLRMQGQSVEAALRM 215
R+EAA + AL+ + E REAL ++++ Q+ + G ++A LR
Sbjct: 632 RMEAAEQARNALQ-------VDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRD 684
Query: 216 ERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALV 275
++ E ++KL++ + HQ + QLE L Q+ ++ EE L
Sbjct: 685 IQEEKEEIQKKLSE---SRHQ----------------QEAATTQLEQLHQEAKRQEEVLA 725
Query: 276 -AKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLE 334
A QE ++E+A L+ + + D Q + + L+ KELL+ L
Sbjct: 726 RAVQEKEALVREKA-----------ALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLF 774
Query: 335 QLQREYSKLKAS 346
+ Q++ S ++ +
Sbjct: 775 EAQQQNSVIEVT 786
Score = 48.9 bits (115), Expect = 8e-06
Identities = 73/346 (21%), Positives = 144/346 (41%), Gaps = 28/346 (8%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHF-QASQREEKEFLMCKFQEARKLVERLGLEKLDL 114
EE + L ++R+ L ++ +E+L + QR E L + + + L L+ L+
Sbjct: 2087 EEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEP 2146
Query: 115 KRQKE-----QALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQA 169
+ Q+E ALR+ E + ++ A+D A AQ + + LQE L+A+ E +
Sbjct: 2147 RLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDS 2206
Query: 170 LEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQ---------SVEAALRMERQAA 220
+ R + E R+ E+E L + +L +G+ VEA +
Sbjct: 2207 EQQRLQDELELTRR-ALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEK 2265
Query: 221 SEEKRKLAQLQVAYHQL------FQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEAL 274
+++L LQ A +L Q ++ ++S++ ER+R +L+ + QA
Sbjct: 2266 QSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERER-RKLKREAMRAAQAGSLE 2324
Query: 275 VAKQEVIDKLKEEAE-QHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQL 333
++K +++ Q + V L+ + + +A ER+ ++ + +L
Sbjct: 2325 ISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSREL 2384
Query: 334 EQLQREYSK---LKASCQESARIE-DMRKRHVEVSQAPLPPAPAYL 375
L S A E+ +E + R+ ++Q+ P P L
Sbjct: 2385 AGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPGPVLL 2430
Score = 48.5 bits (114), Expect = 1e-05
Identities = 60/249 (24%), Positives = 110/249 (44%), Gaps = 30/249 (12%)
Query: 113 DLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEG 172
+L+++ + +E+ LK Q +KA ++ +VT L L +SQ + E K +AL
Sbjct: 255 ELEKEAHERSQELIQLK---SQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALR- 310
Query: 173 RARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQV 232
E LE+ L + + + + S++ ++ Q EE +AQ
Sbjct: 311 ------ETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSG 364
Query: 233 AYHQL------FQEYDNHIKSSVVGSER----KRGMQLEDLKQQLQQAEEALVAKQEVID 282
+ L F ++D + R +R ++DL+QQL +EA+ Q+ D
Sbjct: 365 HENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHD 424
Query: 283 KLKEEAEQHKIVMETVPVLKAQADI---YKADFQAE----RQAREKLAEKKELLQEQLEQ 335
+ +EE K + + + L + D D Q E + RE L + +E L++QLE
Sbjct: 425 QWEEEG---KALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEV 481
Query: 336 LQREYSKLK 344
L++E +L+
Sbjct: 482 LEQEAWRLR 490
Score = 44.3 bits (103), Expect = 2e-04
Identities = 86/381 (22%), Positives = 151/381 (39%), Gaps = 48/381 (12%)
Query: 72 LRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRC 131
L++R EL +++ E + R+ VE L +L + R + K
Sbjct: 281 LQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLS 340
Query: 132 QQQMAEDKASVKAQVTSLLGELQESQSRLE----------------AATKECQALEGRAR 175
QQ+ +D V + + + ++ LE A T L R +
Sbjct: 341 LQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQ 400
Query: 176 AASEQARQLESEREA---LQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQV 232
A + +QL +EA LQQQH DQ +G+ ALR Q + E+ LA V
Sbjct: 401 AVQDLRQQLAGCQEAVNLLQQQH----DQWEEEGK----ALRQRLQKLTGERDTLAGQTV 452
Query: 233 AYHQLFQEYDNHIKSSVVGSERKRGM--QLEDLKQQ----------LQ-QAEEALVAKQE 279
L E D+ K + + + + QLE L+Q+ LQ Q + A K+E
Sbjct: 453 ---DLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEE 509
Query: 280 VIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQRE 339
++L + + + E + L+A+ ++ R+A E + ELL+++ ++
Sbjct: 510 QQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAA 569
Query: 340 YSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPLALP----SQRRSPPEEPPDF 395
++ + S E + E+ K V +A A L+ LAL +Q+ EE
Sbjct: 570 LARAEQSIAELSSSENTLKTEVADLRAAAVKLSA-LNEALALDKVGLNQQLLQLEEENQS 628
Query: 396 CCPKCQYQAPDMDTLQIHVME 416
C + + + LQ+ + E
Sbjct: 629 VCSRMEAAEQARNALQVDLAE 649
Score = 43.9 bits (102), Expect = 3e-04
Identities = 95/431 (22%), Positives = 162/431 (37%), Gaps = 91/431 (21%)
Query: 6 WKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAI 65
W +L + ++ +GGP P E E L R LEE Q+ +++
Sbjct: 69 WCQELEKRLEATGGPI--------------PQRWENVEEPNLDELLVR-LEEEQQRCESL 113
Query: 66 RQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLE--------KLDLKRQ 117
+ N LR E+ + RE+ E L + AR + R + K LK +
Sbjct: 114 AEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGE 173
Query: 118 KEQAL---REV----EHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATK----- 165
+ L REV H + D +KA+ L G L RL +
Sbjct: 174 HGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPN 233
Query: 166 ------------------ECQALEGRARAASEQARQLES----EREALQQ---QHSVQVD 200
+ Q LE A S++ QL+S E+ LQ + S +
Sbjct: 234 GSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLT 293
Query: 201 QLRMQGQSVEAALR----------------MERQA-----ASEEKRKLAQLQVAYHQLFQ 239
Q + Q + E ++ ME +A A EEK L Q+ Q+
Sbjct: 294 QSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMV 353
Query: 240 EYDNHIKSSVVGSERKRGMQLED---LKQQLQQAEEALVAKQEVIDKLKEEA----EQHK 292
E ++I GS + ++L+ + Q A++AL + V+ + ++ +Q
Sbjct: 354 EEGDNIAQ---GSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLA 410
Query: 293 IVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESAR 352
E V +L+ Q D ++ + +A RQ +KL +++ L Q LQ E L + +
Sbjct: 411 GCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQK 470
Query: 353 IEDMRKRHVEV 363
+ ++ +EV
Sbjct: 471 AREELRQQLEV 481
>gi|115511012 coiled-coil domain containing 136 [Homo sapiens]
Length = 1154
Score = 71.6 bits (174), Expect = 1e-12
Identities = 82/350 (23%), Positives = 156/350 (44%), Gaps = 38/350 (10%)
Query: 29 EESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQRE 88
E+ L + LHL + E ++ LE Q+L++ ++ L+ + + F+ S +
Sbjct: 415 EKELLCRLQKLHLQHQNVTCEK-EKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEK 473
Query: 89 EKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAE---------DK 139
+ E + QE ++L + K +L+RQK + + L CQ ++ E DK
Sbjct: 474 DTE-THAQLQEMKQLYQA---SKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDK 529
Query: 140 ASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQV 199
+ +LL L E Q + +A+ KE L+ EQ LE +R ++Q +Q
Sbjct: 530 GKCANKCDTLLSRLTELQEKYKASQKEMGQLQ------MEQCELLEDQRRMQEEQGQLQE 583
Query: 200 DQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQ 259
+ R+ ++ L ++ Q + L +LQ+ Y Q QE E+K+ +Q
Sbjct: 584 ELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLY-QGMQE------------EQKKLIQ 630
Query: 260 LED--LKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQ 317
+D LK+QL+ EE K+ ++ E + K+ + Q+ + QA +
Sbjct: 631 NQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQV 690
Query: 318 AREKLAEKKELLQEQLEQLQREYSKLKAS---CQESARIEDMRKRHVEVS 364
+ K+ELLQ++ +L E +L+A C E ++ ++ +++S
Sbjct: 691 MYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMS 740
Score = 47.8 bits (112), Expect = 2e-05
Identities = 60/279 (21%), Positives = 114/279 (40%), Gaps = 29/279 (10%)
Query: 113 DLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEG 172
+L+ Q Q + E+E + Q +D ++ + E S + E TK+ Q L+G
Sbjct: 60 ELRAQVLQLVAELEETRELAGQHEDDSLELQGLLED---ERLASAQQAEVFTKQIQQLQG 116
Query: 173 RARAASEQARQLESEREA-----LQQQHSVQVDQLRMQGQSVEAALRMERQAAS------ 221
R+ E+ LE E+E+ Q+ H Q + ++ + ++A E AS
Sbjct: 117 ELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLC 176
Query: 222 ---------EEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQ--LEDLKQQLQQA 270
E R ++++A + E + S +G G+Q L++L+++
Sbjct: 177 RMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFL 236
Query: 271 EEALVAKQEVIDKLK---EEAEQHKIVMETVPVLKAQA-DIYKADFQAERQAREKLAEKK 326
E A QE L + E + T L++Q + A+ Q + +
Sbjct: 237 NEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEM 296
Query: 327 ELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQ 365
+LL++QL + + +K CQE + + H +VS+
Sbjct: 297 QLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSE 335
Score = 41.6 bits (96), Expect = 0.001
Identities = 72/314 (22%), Positives = 126/314 (40%), Gaps = 46/314 (14%)
Query: 110 EKLDLKRQKEQALREVEHLKRCQ---QQMAEDKASVKAQVTSLLGELQESQSRLEAAT-- 164
E D++R +E ++ + L+ Q Q E+ + ++ Q+ LL + ++ + L+A
Sbjct: 842 EPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACERE 901
Query: 165 -KECQALEGRARAASE---QARQLESEREALQQQHSVQVDQLRMQGQS--VEAALRMERQ 218
KEC + A + ++L+++ LQ Q+ +D+ QG+ V+ L + Q
Sbjct: 902 FKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDE---QGRLLVVQEQLEGQLQ 958
Query: 219 AASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQ 278
EE R+L + + SVV R + +++ + + V K
Sbjct: 959 CCQEELRQLREK---------------RPSVVKEARGKNAN-KNMNKNANGVKMKKVTKP 1002
Query: 279 EVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQR 338
D + + E K +E V KA + E + E EKK++ +E EQ
Sbjct: 1003 -CSDTSESDLETRKS-LEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGD 1060
Query: 339 EYSKLKASCQESARIEDMRKRH--------VEVSQAPLPPAPAYLSS-----PLAL-PSQ 384
E A +E+ ED + E S+ A + L S PL L S+
Sbjct: 1061 ELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESK 1120
Query: 385 RRSPPEEPPDFCCP 398
+ SP PP F P
Sbjct: 1121 KSSPTPNPPIFSLP 1134
Score = 35.0 bits (79), Expect = 0.13
Identities = 53/280 (18%), Positives = 118/280 (42%), Gaps = 48/280 (17%)
Query: 55 LEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDL 114
L+ Q + ++ + L+E+ E+LL Q +EE + +F+E + +E+ +
Sbjct: 860 LQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEK------PM 913
Query: 115 KRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRA 174
Q ++ +K Q ++ E + +A + + Q RL ++ LEG+
Sbjct: 914 APQNDK-----NEIKELQTKLRELQLQYQASM--------DEQGRLLVVQEQ---LEGQL 957
Query: 175 RAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASE------EKRKLA 228
+ E+ RQL +R ++ ++ + M + ++ + S+ E RK
Sbjct: 958 QCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSL 1017
Query: 229 QLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEA 288
++ + Y S+RK L+ L ++ ++ EE K++V ++ KE+
Sbjct: 1018 EVVLYYK---------------ASQRK----LDGLAKEEEKKEEMEEEKKQVKEEAKEQC 1058
Query: 289 EQHKIVMETVP-VLKAQADIYKADFQAERQAREKLAEKKE 327
+ P K+ D + + E + +E+ +E++E
Sbjct: 1059 GDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEE 1098
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 71.2 bits (173), Expect = 2e-12
Identities = 58/297 (19%), Positives = 141/297 (47%), Gaps = 13/297 (4%)
Query: 59 QELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQK 118
+E +R+ +RE+ ++ + RE++ + + + R+ ++G ++ + Q+
Sbjct: 146 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQE 205
Query: 119 EQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAAS 178
EQ + E +++ ++QM E + ++ Q + + ++ Q + E K+ + + +
Sbjct: 206 EQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMR 265
Query: 179 EQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLF 238
EQ Q+ + E + +Q Q +Q G+ E E Q +E+ Q++ Q+
Sbjct: 266 EQEEQMREQEEQMLKQKE-QTEQEEQTGEQEEQMREQEEQMREQEE----QMREQEEQMR 320
Query: 239 QEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETV 298
++ + K E+K Q+ + K+Q+ + EE + ++E + K +E+ + + M
Sbjct: 321 EQEEQMGKQEEQMWEQKE--QMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMR-- 376
Query: 299 PVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIED 355
K + + K + Q +Q E++ E+KE + EQ EQ++ + ++ ++ + E+
Sbjct: 377 ---KQEEQMRKQEEQMRKQ-EEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEE 429
Score = 67.8 bits (164), Expect = 2e-11
Identities = 65/308 (21%), Positives = 146/308 (47%), Gaps = 11/308 (3%)
Query: 66 RQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVE--RLGLEKLDLKRQKEQALR 123
R +N+ L+E+ EL EK + +E ++ +E ++ L + R++E +R
Sbjct: 3 RITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVR 62
Query: 124 EVEHLKRCQQ-QMAEDKASVK---AQVTSLLGELQESQSRLEAATKECQALEGRARAASE 179
E E R Q+ Q+ E + V+ QV G+++E + ++ + + EG+ R
Sbjct: 63 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 122
Query: 180 QARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQ 239
Q R+ E + + Q Q Q+R Q V R+ + + + Q++ Q+ +
Sbjct: 123 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV-R 181
Query: 240 EYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVM--ET 297
E + ++ + G Q+ + ++Q+ + EE + ++E + + +E+ + + M +
Sbjct: 182 EQEGQVREQEGQMGEQEG-QMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQE 240
Query: 298 VPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMR 357
V K + + K + Q +Q E++ E++E ++EQ EQ+ ++ + + Q + E MR
Sbjct: 241 EQVQKQEEQVQKQEEQMRKQ-EEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMR 299
Query: 358 KRHVEVSQ 365
++ ++ +
Sbjct: 300 EQEEQMRE 307
Score = 66.6 bits (161), Expect = 4e-11
Identities = 61/319 (19%), Positives = 154/319 (48%), Gaps = 15/319 (4%)
Query: 59 QELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQK 118
+E +R+ +RE+ ++ + RE++ + + + R+ ++ ++ ++ Q+
Sbjct: 83 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 142
Query: 119 EQALREVEHLKRCQQQMAEDKASVK---AQVTSLLGELQESQSRLEAATKECQALEGRAR 175
Q + ++ + Q+ E + V+ QV G+++E + ++ + EG+
Sbjct: 143 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMG 202
Query: 176 AASEQARQLESEREALQQQHSVQVDQLRMQ----GQSVEAALRMERQAASEE---KRKLA 228
EQ + E + + ++Q Q +Q+R Q G+ E + E Q +E +++
Sbjct: 203 EQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEE 262
Query: 229 QLQVAYHQLFQEYDNHIKSSV-VGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEE 287
Q++ Q+ ++ + +K E + G Q E +++Q +Q E +E ++++E+
Sbjct: 263 QMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQ 322
Query: 288 AEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASC 347
EQ E + K Q +++ Q +Q E++ E++E +Q+Q EQ++++ +++
Sbjct: 323 EEQMGKQEEQMWEQKEQ--MWEQKEQMWKQ-EEQMGEQEEQMQKQEEQVRKQEEQMRKQE 379
Query: 348 QESARIED-MRKRHVEVSQ 365
++ + E+ MRK+ ++ +
Sbjct: 380 EQMRKQEEQMRKQEEQMGE 398
Score = 65.9 bits (159), Expect = 7e-11
Identities = 59/334 (17%), Positives = 154/334 (46%), Gaps = 20/334 (5%)
Query: 41 LPSEQGAPETLQRCLEENQELRDA---IRQSNQILRERCEELLHFQASQREEKEFLMCKF 97
LP E E + E+ ++R+ +R+ +RE+ ++ + RE++ + +
Sbjct: 48 LPQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 107
Query: 98 QEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQ 157
+ R+ ++ ++ ++ Q+ Q + ++ + Q+ E + V+ Q G+++E +
Sbjct: 108 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE----GQVREQE 163
Query: 158 SRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMER 217
++ + + EG+ R Q R+ E + + Q Q +Q+ G+ E + E
Sbjct: 164 GQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQM---GEQEEQMQKQEE 220
Query: 218 QAASEEK--RKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALV 275
Q +E+ RK + + Q+ + ++ RK+ Q+ + ++Q+++ EE ++
Sbjct: 221 QMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEE-QMRKQEEQMREQEEQMREQEEQML 279
Query: 276 AKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLA-------EKKEL 328
++E ++ ++ EQ + + E ++ Q + + + R+ E++ E+KE
Sbjct: 280 KQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQ 339
Query: 329 LQEQLEQLQREYSKLKASCQESARIEDMRKRHVE 362
+ EQ EQ+ ++ ++ ++ + E+ ++ E
Sbjct: 340 MWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEE 373
Score = 55.1 bits (131), Expect = 1e-07
Identities = 52/274 (18%), Positives = 117/274 (42%), Gaps = 36/274 (13%)
Query: 7 KSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEEN-------- 58
+ Q +M + G ++ +GE+ + M + G E R EE
Sbjct: 188 REQEGQMGEQEGQMGEQEEQMGEQ----EEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQV 243
Query: 59 QELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQK 118
Q+ + +++ + +R++ EE + Q Q E+E M K +E + E+ G ++ ++ Q+
Sbjct: 244 QKQEEQVQKQEEQMRKQ-EEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQE 302
Query: 119 EQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAAS 178
EQ + E ++ ++QM E + + Q + + ++ + E K+ + + +
Sbjct: 303 EQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQ 362
Query: 179 EQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLF 238
+Q Q+ + E +++Q +Q+R Q E +R + + E+K ++ +
Sbjct: 363 KQEEQVRKQEEQMRKQE----EQMRKQ----EEQMRKQEEQMGEQKEQMGEQ-------- 406
Query: 239 QEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEE 272
K + E + G Q E +++Q + E
Sbjct: 407 -------KEQMREQEEQMGEQKEQMRKQEEHMGE 433
Score = 49.3 bits (116), Expect = 7e-06
Identities = 36/167 (21%), Positives = 81/167 (48%), Gaps = 8/167 (4%)
Query: 29 EESPLGKPAMLHLPSEQGAPETLQRCLEEN-QELRDAIRQSNQILRERCEELLHFQASQR 87
EE L + + G E R EE +E + +R+ + +RE+ E++ +
Sbjct: 275 EEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMW 334
Query: 88 EEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVT 147
E+KE + + ++ K E++G ++ +++Q+EQ ++ E +++ ++QM + + ++ Q
Sbjct: 335 EQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQ-E 393
Query: 148 SLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQ 194
+GE +E + +E + G EQ Q+ + E + +Q
Sbjct: 394 EQMGEQKEQMGEQKEQMREQEEQMG------EQKEQMRKQEEHMGEQ 434
Score = 48.9 bits (115), Expect = 8e-06
Identities = 30/155 (19%), Positives = 72/155 (46%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLK 115
+E E + + + +RE+ E++ + RE++E + + ++ K E++ +K +
Sbjct: 282 KEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMW 341
Query: 116 RQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRAR 175
QKEQ ++ E + ++QM + + V+ Q + + ++ + + E K+ + + +
Sbjct: 342 EQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKE 401
Query: 176 AASEQARQLESEREALQQQHSVQVDQLRMQGQSVE 210
EQ Q+ + E + +Q Q G+ E
Sbjct: 402 QMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 45.4 bits (106), Expect = 9e-05
Identities = 36/196 (18%), Positives = 94/196 (47%), Gaps = 20/196 (10%)
Query: 45 QGAPETLQRCLEENQELRDAIRQSNQILRERCEELL-------------HFQASQREEKE 91
Q E +Q+ E+ ++ + +R+ + +RE+ E++L + RE++E
Sbjct: 244 QKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEE 303
Query: 92 FLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLG 151
+ + ++ R+ E++ ++ + +Q+EQ + E + ++QM + + + Q
Sbjct: 304 QMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEE---- 359
Query: 152 ELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSV-- 209
++Q+ + ++ ++ + E + R EQ R+ E + ++Q Q +Q+R Q + +
Sbjct: 360 QMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGE 419
Query: 210 -EAALRMERQAASEEK 224
+ +R + + E+K
Sbjct: 420 QKEQMRKQEEHMGEQK 435
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 70.5 bits (171), Expect = 3e-12
Identities = 71/329 (21%), Positives = 157/329 (47%), Gaps = 39/329 (11%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLK 115
E+ + L + + + + +RE EE +H Q RE++E K QE K+ E+ ++ + K
Sbjct: 363 EKMRRLEEMMWEKEEKIRE-LEEKMHEQEKIREQEE----KRQEEEKIREQEKRQEQEAK 417
Query: 116 --------RQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKEC 167
R++E+ +RE E Q++ ++ ++ + + QE R E +E
Sbjct: 418 MWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR---QEQEEMWRQEEKIREQ 474
Query: 168 QALEGRARAASEQARQLESEREALQQQHSV--QVDQLRMQGQSV---EAALRMERQAASE 222
+ + + EQ + + E + +Q+ + Q +++R Q + + E +R + + E
Sbjct: 475 EEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIRE 534
Query: 223 EKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQ--LQQAEEALVAKQEV 280
++ K+ + + ++ QE E K G Q E +++Q +++ EE + ++E
Sbjct: 535 QEEKIREQE----EMMQE-----------QEEKMGEQEEKMQEQEKMRRQEEKIREQEEK 579
Query: 281 IDKLKEEA-EQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQRE 339
I + KE+ EQ + + E ++ Q ++ + + + EK+ E++E +QEQ E+++R+
Sbjct: 580 IREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 639
Query: 340 YSKLKASCQESARIEDMRKRHVEVSQAPL 368
K+ + E+ + H E +A +
Sbjct: 640 EEKMWEQEVRLRQQEEKMQEHQEHLEAAI 668
Score = 70.1 bits (170), Expect = 4e-12
Identities = 59/345 (17%), Positives = 161/345 (46%), Gaps = 35/345 (10%)
Query: 45 QGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLV 104
Q E + R E+ QE + I++ + +RE+ E++ + R ++E + K ++ R+
Sbjct: 296 QQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQE 355
Query: 105 ERLGLEKLDLKR------QKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQS 158
E + ++ ++R +KE+ +RE+E Q+++ E + K Q + E ++ Q
Sbjct: 356 EMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEE--KRQEEEKIREQEKRQE 413
Query: 159 RLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSV--------- 209
+ ++ + + + EQ +++ + E + +Q ++ ++ R + + +
Sbjct: 414 QEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE 473
Query: 210 EAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIK------------SSVVGSERKRG 257
+ + +++ E+++ Q + + Q + +D K + E K
Sbjct: 474 QEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIR 533
Query: 258 MQLEDLKQQ---LQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQA 314
Q E +++Q +Q+ EE + ++E + + ++ Q + + E ++ Q + + +
Sbjct: 534 EQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEK 593
Query: 315 ERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKR 359
+ EK+ E++E++QEQ E++ + K+ C++ ++++ ++
Sbjct: 594 IWEQEEKIREQEEMMQEQEEKMWEQEEKM---CEQEEKMQEQEEK 635
Score = 66.6 bits (161), Expect = 4e-11
Identities = 68/347 (19%), Positives = 165/347 (47%), Gaps = 27/347 (7%)
Query: 40 HLPSE-QGAPETLQRCLEEN-------QELRDAIRQSNQILRERCEELLHFQASQREEKE 91
HL E Q LQ +EEN Q+ + + + + ++E E++ + RE++E
Sbjct: 269 HLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE 328
Query: 92 FLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLG 151
+ + ++ R+ E + ++ ++RQ+E + E ++R ++ M E + ++ ++ +
Sbjct: 329 KIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIR-ELEEKMH 387
Query: 152 ELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEA 211
E QE E +E + + + + ++A+ E + +Q+ ++ + +M Q E
Sbjct: 388 E-QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQ--EE 444
Query: 212 ALRMERQAASEEKRKLAQLQVAYHQLFQEYDN--------HIKSSVVGSERKRGMQ---L 260
+ + + EEKR+ + + +E + H + + E K Q +
Sbjct: 445 KIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKM 504
Query: 261 EDLKQQLQQAEEALVAKQEVIDKLKEE-AEQHKIVMETVPVLKAQADIYKADFQAER-QA 318
D ++++++ EE + ++E I + +E+ EQ + + E +++ Q + K Q E+ Q
Sbjct: 505 HDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEE--KMGEQEEKMQE 562
Query: 319 REKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQ 365
+EK+ ++E ++EQ E+++ + K++ ++ E+ + E+ Q
Sbjct: 563 QEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQ 609
Score = 39.7 bits (91), Expect = 0.005
Identities = 30/115 (26%), Positives = 63/115 (54%), Gaps = 11/115 (9%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
E ++R E+ +E + IR+ + +RE+ E++ + RE++E M + QE E++
Sbjct: 564 EKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEE--MMQEQE-----EKMW 616
Query: 109 LEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAA 163
++ + Q+E+ + E ++R +++M E + ++ Q ++QE Q LEAA
Sbjct: 617 EQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE----KMQEHQEHLEAA 667
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 70.5 bits (171), Expect = 3e-12
Identities = 80/325 (24%), Positives = 144/325 (44%), Gaps = 44/325 (13%)
Query: 40 HLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFL---MCK 96
HL +Q E L+R E + LR + Q + +++ HFQ + ++ L +
Sbjct: 1643 HLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIE 1702
Query: 97 FQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQES 156
+ + L E L E L L+ + E + L+R + + DK A + L +LQ S
Sbjct: 1703 IERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDK---NATILELRSQLQIS 1759
Query: 157 QSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRME 216
+R T E Q L L+ ERE L+Q+ + Q Q++EA+ R++
Sbjct: 1760 NNR----TLELQGL----------INDLQRERENLRQEIE------KFQKQALEASNRIQ 1799
Query: 217 R------QAASEEKRKLAQLQV-----AYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQ 265
Q E + L +++V A Q ++ N KS++ R + +LE KQ
Sbjct: 1800 ESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVK-QRLECEKQ 1858
Query: 266 QLQ----QAEEALVAKQEVIDKLKEEAEQHKIVMETV--PVLKAQADIYKADFQAERQAR 319
Q+Q Q + K+E I K++ E E+ + ++ + + QA+I + + + R+
Sbjct: 1859 QIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLE 1918
Query: 320 EKLAEKKELLQEQLEQLQREYSKLK 344
+ E + L+ + + QRE KL+
Sbjct: 1919 DSTRETQSQLETERSRYQREIDKLR 1943
Score = 56.2 bits (134), Expect = 5e-08
Identities = 63/315 (20%), Positives = 143/315 (45%), Gaps = 20/315 (6%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
+ +Q+ E+N + ++ ++ + ++++ +E+ +A +EE + E K+
Sbjct: 1297 QVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYD 1356
Query: 109 LEKLDLKRQKEQALREVE-HLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKEC 167
E + LK Q E + + + + Q ED + +AQ+ +L E + + ++E
Sbjct: 1357 EEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENR-------SLSEEI 1409
Query: 168 QALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKL 227
+ L+ +E R++E E +QQQ + ++ + Q +E LR Q +EE +
Sbjct: 1410 KRLKNTLTQTTENLRRVE---EDIQQQKATG-SEVSQRKQQLEVELRQVTQMRTEESVRY 1465
Query: 228 AQLQVAYHQLFQEYDNHIK--SSVVGSERKRGMQLEDLKQQLQQA----EEALVAKQEVI 281
Q + Q+ + I+ ++ E LED +LQ+ ++A + E I
Sbjct: 1466 KQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETI 1525
Query: 282 DKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYS 341
+KLK + ++ + + + + D + + ++L +K+ ++E+L +L+R S
Sbjct: 1526 NKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTAS 1585
Query: 342 KLKASCQESARIEDM 356
+ SC+ E++
Sbjct: 1586 --EDSCKRKKLEEEL 1598
Score = 48.1 bits (113), Expect = 1e-05
Identities = 59/316 (18%), Positives = 129/316 (40%), Gaps = 13/316 (4%)
Query: 51 LQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLE 110
LQR + Q+ + ++ L+ + +EL + + K Q+ + L
Sbjct: 1507 LQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLK-- 1564
Query: 111 KLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQAL 170
+L+ QK++ E+ LKR + + + ++ ++ + L+E ++ T++ +
Sbjct: 1565 --ELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQA 1622
Query: 171 EGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQL 230
+ + + RQ + ++ ++LR VEA R Q +E K A L
Sbjct: 1623 SIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQ--EQESVKQAHL 1680
Query: 231 QVAYHQ-LFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAE 289
+ + Q ++ + S + ER + + K+ L EE + E D + +E
Sbjct: 1681 RNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE 1740
Query: 290 QHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQE 349
T+ L++Q I + L ++E L++++E+ Q K + +
Sbjct: 1741 ADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQ------KQALEA 1794
Query: 350 SARIEDMRKRHVEVSQ 365
S RI++ + + +V Q
Sbjct: 1795 SNRIQESKNQCTQVVQ 1810
Score = 40.8 bits (94), Expect = 0.002
Identities = 56/305 (18%), Positives = 125/305 (40%), Gaps = 38/305 (12%)
Query: 45 QGAPETLQRCLEENQELRDAIRQSNQILRE--RCEELLHFQASQREEKEFLMCKFQEARK 102
+ A + L +C + +EL + I + + + R + + + Q++ + K ++ K
Sbjct: 1091 KSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEK 1150
Query: 103 LVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEA 162
E LG +KL+ ++ ++ E+E L+ Q+ K + ++ + E S L
Sbjct: 1151 --ENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLR- 1207
Query: 163 ATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASE 222
E +++ ++E + Q+D+L R R E
Sbjct: 1208 -----NKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLS----------RENRDLKDE 1252
Query: 223 EKRKLAQLQVAYHQLFQEYDNHIKSSVVGSE---RKRGMQLEDLKQQLQQAEEALVAKQE 279
R + A Q + +N ++ GSE +K+ +++E LKQ +QQ E ++
Sbjct: 1253 IVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIE-LKQVMQQRSEDNARHKQ 1311
Query: 280 VIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAR----EKLAEKKELLQEQLEQ 335
+++ +T+ + + KA+FQ E + R +L++ + E++
Sbjct: 1312 SLEE----------AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIIS 1361
Query: 336 LQREY 340
L+ ++
Sbjct: 1362 LKNQF 1366
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 70.5 bits (171), Expect = 3e-12
Identities = 79/342 (23%), Positives = 147/342 (42%), Gaps = 64/342 (18%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQRE-----------------EKE 91
E L + LEE D + ++ L++ ++L QR+ E++
Sbjct: 1402 EALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEK 1461
Query: 92 FLMCKFQEARKLVERLGLEK----LDLKRQKEQALREVEHLKRCQQQMA---EDKASVKA 144
+ ++ E R E EK L L R E+AL E +R +Q+ ED S K
Sbjct: 1462 SISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKD 1521
Query: 145 QVTSLLGELQESQSRLEAATKECQA----LEGRARAASEQARQLESEREALQQQHSVQVD 200
V + EL++S+ LE +E + LE +A + +LE +A++ Q +
Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL- 1580
Query: 201 QLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQL 260
R +EEK++L QV + E + ++ V S++K + L
Sbjct: 1581 --------------QTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDL 1626
Query: 261 EDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQARE 320
+DL+ Q++ A + A+ EVI +L++ L+AQ Y+ + + R +R+
Sbjct: 1627 KDLEAQIEAANK---ARDEVIKQLRK--------------LQAQMKDYQRELEEARASRD 1669
Query: 321 KLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVE 362
++ + + +++L+ L+ E +L QE + +RH E
Sbjct: 1670 EIFAQSKESEKKLKSLEAEILQL----QEELASSERARRHAE 1707
Score = 65.1 bits (157), Expect = 1e-10
Identities = 77/350 (22%), Positives = 143/350 (40%), Gaps = 71/350 (20%)
Query: 60 ELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKE 119
EL + R+ Q+L E+ + A Q + + L F EA ++ RL +K +L+
Sbjct: 874 ELEEMERKHQQLLEEK-----NILAEQLQAETEL---FAEAEEMRARLAAKKQELEEILH 925
Query: 120 QALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASE 179
VE + Q + +K ++A + L +L E + + E E + + E
Sbjct: 926 DLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEE 985
Query: 180 QARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRK-LAQLQVAYHQLF 238
+ LE + ++ + D++ A + A EEK K LA+++ +
Sbjct: 986 EILLLEDQNSKFIKEKKLMEDRI---------AECSSQLAEEEEKAKNLAKIRNKQEVMI 1036
Query: 239 QEYDNHIKSSVVGSERKRGMQLEDLKQQLQ----QAEEALVAKQEVIDKLK--------- 285
+ + +K E K +LE K++L ++ + Q ID+LK
Sbjct: 1037 SDLEERLKK-----EEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEE 1091
Query: 286 ---------EEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQL 336
+E ++ V L+AQ + DF++E+ +R K ++K L E+LE L
Sbjct: 1092 LQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEAL 1151
Query: 337 ---------------------QREYSKLKASCQE-----SARIEDMRKRH 360
++E ++LK + +E A+I+DMR+RH
Sbjct: 1152 KTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRH 1201
Score = 58.2 bits (139), Expect = 1e-08
Identities = 62/274 (22%), Positives = 120/274 (43%), Gaps = 30/274 (10%)
Query: 99 EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQES-- 156
E K + +L + D +R+ E+A + + ++ + S++A++ L EL S
Sbjct: 1642 EVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSER 1701
Query: 157 ------QSRLEAATKECQALEGRARAASEQAR------QLESEREALQQQHSVQVDQLR- 203
Q R E A + + G++ E+ R QLE E E Q + D+ R
Sbjct: 1702 ARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRK 1761
Query: 204 --MQGQSVEAALRMERQAASEEKRKLAQLQVAYHQL---FQEYDNHIKSSVVGSERKRGM 258
+Q ++ A L ER AA + QL+ +L QE + +KS +
Sbjct: 1762 TTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEA 1821
Query: 259 QLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQA 318
++ L++QL+Q + A +++ + +++ ++ + V + AD YK +
Sbjct: 1822 KIGQLEEQLEQEAKERAAANKLVRRTEKKLKE---IFMQVEDERRHADQYK-------EQ 1871
Query: 319 REKLAEKKELLQEQLEQLQREYSKLKASCQESAR 352
EK + + L+ QLE+ + E ++ AS ++ R
Sbjct: 1872 MEKANARMKQLKRQLEEAEEEATRANASRRKLQR 1905
Score = 57.4 bits (137), Expect = 2e-08
Identities = 74/336 (22%), Positives = 139/336 (41%), Gaps = 55/336 (16%)
Query: 50 TLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL 109
+L R LEE E ++ + N+ LR E+L+ S +++ + + +++++ +E+
Sbjct: 1487 SLARALEEALEAKEEFERQNKQLRADMEDLM----SSKDDVGKNVHELEKSKRALEQQVE 1542
Query: 110 EKLDLKRQKEQALREVEHLK-RCQQQMAEDKASVKAQVTS-----------LLGELQESQ 157
E + E L+ E K R + M KA + + + L+ +++E +
Sbjct: 1543 EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELE 1602
Query: 158 SRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLR-MQGQSVEAALRME 216
+ LE K+ + + LE++ EA + + QLR +Q Q + +E
Sbjct: 1603 AELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELE 1662
Query: 217 RQAAS---------EEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQL 267
AS E ++KL L+ QL +E + SER R ++ +
Sbjct: 1663 EARASRDEIFAQSKESEKKLKSLEAEILQLQEE--------LASSERARRHAEQERDELA 1714
Query: 268 QQAEEALVAKQEVIDK----------LKEEAEQHKIVMETVP----VLKAQADIYKADFQ 313
+ + K ++D+ L+EE E+ + ME + Q D A+
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Query: 314 AERQAREKLAEKKELLQEQLEQLQREYSKLKASCQE 349
AER A +K + +QL+R+ +LKA QE
Sbjct: 1775 AERSAAQKSDNAR-------QQLERQNKELKAKLQE 1803
Score = 54.7 bits (130), Expect = 2e-07
Identities = 65/331 (19%), Positives = 149/331 (45%), Gaps = 35/331 (10%)
Query: 57 ENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKR 116
+N+EL ++ Q+ E + A +E L K E +L L + L+
Sbjct: 1232 DNKELACEVKVLQQVKAESEHKRKKLDAQVQE----LHAKVSEGDRLRVELAEKASKLQN 1287
Query: 117 QKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARA 176
+ + +E ++ + A+D AS+++Q LQ++Q L+ T++ L R R
Sbjct: 1288 ELDNVSTLLEEAEKKGIKFAKDAASLESQ-------LQDTQELLQEETRQKLNLSSRIRQ 1340
Query: 177 ASEQARQLESEREALQQ-QHSVQVDQLRMQGQSVEAALRMER-----QAASEEKRKLAQL 230
E+ L+ ++E ++ + +++ L +Q Q + +++ ++ E K+KL +
Sbjct: 1341 LEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKD 1400
Query: 231 QVAYHQLFQE----YD------NHIKSSV------VGSERKRGMQLEDLKQQLQQ--AEE 272
A Q +E YD N ++ + + +R+ LE +++ Q AEE
Sbjct: 1401 AEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEE 1460
Query: 273 ALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQ 332
++ + ++ + EAE + + + + +A + +A + ERQ ++ A+ ++L+ +
Sbjct: 1461 KSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSK 1520
Query: 333 LEQLQREYSKLKASCQESARIEDMRKRHVEV 363
+ + + K+ ++E+MR + E+
Sbjct: 1521 DDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551
Score = 54.3 bits (129), Expect = 2e-07
Identities = 77/348 (22%), Positives = 150/348 (43%), Gaps = 34/348 (9%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
E L+ E ++ D ++ +R +E+ + + EE + + Q+ R +R
Sbjct: 1146 EELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMR---QRHA 1202
Query: 109 LEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSL---LGELQESQSRLEAATK 165
+L Q EQA R +L++ +Q + D + +V L E + + +L+A +
Sbjct: 1203 TALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQ 1262
Query: 166 ECQA--LEG-RARA-ASEQARQLESERE---ALQQQHSVQVDQLRMQGQSVEAALRMERQ 218
E A EG R R +E+A +L++E + L ++ + + S+E+ L+ ++
Sbjct: 1263 ELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQE 1322
Query: 219 AASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGM---------QLEDLK----- 264
EE R+ L QL +E ++ + E ++ + QL D K
Sbjct: 1323 LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDD 1382
Query: 265 -----QQLQQAEEALVAKQEVI-DKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQA 318
+ L++A++ L+ E + +L+E+A + + +T L+ + D D +RQ
Sbjct: 1383 DLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQV 1442
Query: 319 REKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQA 366
L EKK+ +QL ++ S A ++ A E K +S A
Sbjct: 1443 ASNL-EKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLA 1489
Score = 53.9 bits (128), Expect = 3e-07
Identities = 71/360 (19%), Positives = 149/360 (41%), Gaps = 45/360 (12%)
Query: 21 AADQDVLGEESPLGKPAMLHLPSEQGAPETLQRC------LEENQELRDAIRQSNQILRE 74
A +++ E+ + H + + E L++ LE+N++ + N+ L
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQ---GLETDNKELAC 1238
Query: 75 RCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQ 134
+ L +A +++ L + QE V +++L + + E++++ ++
Sbjct: 1239 EVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEE 1298
Query: 135 MAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQ- 193
+ SL +LQ++Q L+ T++ L R R E+ L+ ++E ++
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358
Query: 194 QHSVQVDQLRMQGQSVEAALRMER-----QAASEEKRKLAQLQVAYHQLFQE----YDNH 244
+ +++ L +Q Q + +++ ++ E K+KL + A Q +E YD
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKL 1418
Query: 245 IKSSVVGSERKRGMQLEDLKQQL---QQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVL 301
K+ + + +L+DL L +Q L KQ+ D+L E +
Sbjct: 1419 EKT-----KNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS----------- 1462
Query: 302 KAQADIYKADFQAERQAREK------LAEKKELLQEQLEQLQREYSKLKASCQESARIED 355
A + +AE +AREK LA E E E+ +R+ +L+A ++ +D
Sbjct: 1463 -ISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKD 1521
Score = 50.1 bits (118), Expect = 4e-06
Identities = 58/301 (19%), Positives = 135/301 (44%), Gaps = 53/301 (17%)
Query: 51 LQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLE 110
L+ +E + RD + + + L+ + ++ R ++ + + +E+ K ++ L E
Sbjct: 1629 LEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAE 1688
Query: 111 KLDLKRQKEQALREVEHLKRCQQQMAED--------------KASVKAQVTSLLGELQES 156
L L+ + + R H ++ + ++A++ K ++A++ L EL+E
Sbjct: 1689 ILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEE 1748
Query: 157 QSRLEA-------ATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSV 209
QS +E T + L A A++ ++ R+ L++Q+ +L+ + Q +
Sbjct: 1749 QSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNK----ELKAKLQEL 1804
Query: 210 EAALRMERQAA-SEEKRKLAQLQ----------VAYHQLFQEYDNHIKSSVVGSERKR-- 256
E A++ + +A S + K+ QL+ A ++L + + +K + E +R
Sbjct: 1805 EGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRH 1864
Query: 257 -----------GMQLEDLKQQLQQAEE----ALVAKQEVIDKLKEEAEQHKIVMETVPVL 301
+++ LK+QL++AEE A +++++ +L + E ++ + V L
Sbjct: 1865 ADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTL 1924
Query: 302 K 302
K
Sbjct: 1925 K 1925
Score = 43.1 bits (100), Expect = 5e-04
Identities = 55/278 (19%), Positives = 122/278 (43%), Gaps = 26/278 (9%)
Query: 115 KRQKEQALREVEH-------LKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKEC 167
K+Q+ AL+ ++ L+ Q K QVT ELQ L ++
Sbjct: 809 KQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQ 868
Query: 168 QALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKL 227
+EG + ++E + + L ++ ++ +QL+ + + A M + A++++
Sbjct: 869 TKVEG-------ELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQ--- 918
Query: 228 AQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQ--LEDLKQQLQQAEEALVAKQEVIDKLK 285
+L+ H L + + + + K+ MQ ++DL++QL + E A Q ++K+
Sbjct: 919 -ELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ--LEKVT 975
Query: 286 EEAEQHKIVMETVPVLKAQADIYKADFQAERQARE---KLAEKKELLQEQLEQLQREYSK 342
EA+ K+ E + + + K E + E +LAE++E + L +++ +
Sbjct: 976 AEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEE-KAKNLAKIRNKQEV 1034
Query: 343 LKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPLA 380
+ + +E + E+ ++ +E ++ L L +A
Sbjct: 1035 MISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA 1072
Score = 35.8 bits (81), Expect = 0.074
Identities = 34/133 (25%), Positives = 68/133 (51%), Gaps = 15/133 (11%)
Query: 215 MERQAASEEKRKLAQLQV------AYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQ 268
+ R+A ++++++L+ L+V AY +L H + V ++ K +Q+ +++LQ
Sbjct: 801 LARKAFAKKQQQLSALKVLQRNCAAYLKL-----RHWQWWRVFTKVKPLLQVTRQEEELQ 855
Query: 269 QAEEALVAKQEVIDKLKEEAEQ----HKIVMETVPVLKAQADIYKADFQAERQAREKLAE 324
+E L+ +E K++ E E+ H+ ++E +L Q F + R +LA
Sbjct: 856 AKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAA 915
Query: 325 KKELLQEQLEQLQ 337
KK+ L+E L L+
Sbjct: 916 KKQELEEILHDLE 928
Score = 28.9 bits (63), Expect = 9.1
Identities = 30/147 (20%), Positives = 62/147 (42%), Gaps = 8/147 (5%)
Query: 56 EENQELRDAIRQSNQILRERCEEL-----LHFQAS-QREEKEFLMCKFQEARKLVERLGL 109
+++ R + + N+ L+ + +EL F+A+ E + + Q ++ ER
Sbjct: 1781 QKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAA 1840
Query: 110 EKLDLKRQKE--QALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKEC 167
KL + +K+ + +VE +R Q E A++ L +L+E++ A
Sbjct: 1841 NKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR 1900
Query: 168 QALEGRARAASEQARQLESEREALQQQ 194
+ L+ A+E L E L+ +
Sbjct: 1901 RKLQRELDDATEANEGLSREVSTLKNR 1927
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 70.5 bits (171), Expect = 3e-12
Identities = 71/335 (21%), Positives = 147/335 (43%), Gaps = 39/335 (11%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
E +R EE ++ + + +E Q + E E LM +A + E L
Sbjct: 858 EDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLM----DAEERCEGLI 913
Query: 109 LEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
K+ L+ + ++ +E + ++ K +++ + +SL ++ + + L KE
Sbjct: 914 KSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKH 973
Query: 169 ALEGRARAASEQARQLES-------EREALQQQHSVQVDQLRMQGQSVEAALR----MER 217
A E + + SE+ LE E+++LQ+ H +D L+++ V ++ +E+
Sbjct: 974 ATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQ 1033
Query: 218 Q------AASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAE 271
Q + +EK+ A L+ A K + G + + DL+ QQ E
Sbjct: 1034 QTDDLEGSLEQEKKLRADLERA------------KRKLEGDLKMSQESIMDLENDKQQIE 1081
Query: 272 EALVAKQEVIDKLKEEAEQHKI----VMETVPVLKAQADIYKADFQAERQAREKLAEKKE 327
E L K+ + +L+ + + ++ + + L+A+ + + + +AE R K+ +++
Sbjct: 1082 EKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRS 1141
Query: 328 LLQEQLEQLQREYSKLKASCQESARIEDMRKRHVE 362
L +LE++ +AS SA+IE +KR E
Sbjct: 1142 DLARELEEISERLE--EASGATSAQIEMNKKREAE 1174
Score = 65.1 bits (157), Expect = 1e-10
Identities = 69/326 (21%), Positives = 143/326 (43%), Gaps = 44/326 (13%)
Query: 55 LEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVER----LGLE 110
LEE +E+ + + L ++C L ++ E + K ++ + E L E
Sbjct: 930 LEEEEEMNSELVAKKRNLEDKCSSLKR----DIDDLELTLTKVEKEKHATENKVKNLSEE 985
Query: 111 KLDLKRQKEQALREVEHLKRCQQQMAED--------------KASVKAQVTSLLGELQES 156
L+ + +E + L+ QQ +D A ++ Q L G L++
Sbjct: 986 MTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQE 1045
Query: 157 QSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRME 216
+ + + LEG + + E LE++++ ++++ + +L ++A + E
Sbjct: 1046 KKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFEL----SQLQAKIDDE 1101
Query: 217 RQAASEEKRKLAQLQVAYHQLFQEYD--NHIKSSVVGSERKRGMQLEDLKQQLQQAEEAL 274
+ + + ++K+ +LQ +L +E + + +++ + +LE++ ++L++A A
Sbjct: 1102 QVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGAT 1161
Query: 275 VAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQA---REKLAEKKELLQE 331
A+ E+ K EAE K+ + D+ +A Q E A R+K A+ L E
Sbjct: 1162 SAQIEM--NKKREAEFQKM----------RRDLEEATLQHEATAATLRKKQADSVAELGE 1209
Query: 332 QLEQLQREYSKL-KASCQESARIEDM 356
Q++ LQR KL K + I+DM
Sbjct: 1210 QIDNLQRVKQKLEKEKSELKMEIDDM 1235
Score = 59.3 bits (142), Expect = 6e-09
Identities = 89/381 (23%), Positives = 164/381 (43%), Gaps = 69/381 (18%)
Query: 29 EESPLGKPAMLH-LPSEQGAPETLQRCLEENQE----LRDAIRQSNQILRE--------- 74
EE K AM H L S + + L+ EE QE L+ A+ ++N + +
Sbjct: 1324 EEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDA 1383
Query: 75 --RCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQ 132
R EEL E K+ L + QEA + E + L++ K++ EVE L R
Sbjct: 1384 IQRTEEL-------EEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDL 1436
Query: 133 QQMAEDKASV---KAQVTSLLGE----LQESQSRLEAATKECQALEGRA----RAASEQA 181
++ A++ + +L E L ESQ+ LEAA KE ++L A E
Sbjct: 1437 ERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVV 1496
Query: 182 RQLES---EREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLF 238
QLE+ E + LQ++ S +Q+ G++++ A + ++ E+ + LQVA ++
Sbjct: 1497 DQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEK----SDLQVALEEVE 1552
Query: 239 QEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETV 298
+ H +S ++ +QLE L Q + + ++ K E I++LK +++ +++V
Sbjct: 1553 GSLE-HEESKIL------RVQLE-LSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSV 1604
Query: 299 PVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRK 358
AE ++R K+ ++ L +++ + E+ +
Sbjct: 1605 -------------LDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAET-------Q 1644
Query: 359 RHVEVSQAPLPPAPAYLSSPL 379
+H+ Q L + +L L
Sbjct: 1645 KHLRTVQGQLKDSQLHLDDAL 1665
Score = 54.3 bits (129), Expect = 2e-07
Identities = 65/337 (19%), Positives = 146/337 (43%), Gaps = 51/337 (15%)
Query: 49 ETLQRCLEENQELRDAIRQSN---QILRERCEELLHFQASQREEKEFLMCKFQEARKLVE 105
E + + +E + L++A +Q+ Q+ ++ L+ A ++ + L ++ +KL
Sbjct: 991 ENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRA 1050
Query: 106 RLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLG-------------- 151
L K L+ + + + L+ +QQ+ E + +++ L
Sbjct: 1051 DLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQK 1110
Query: 152 ELQESQSRLEAATKECQALEGRARA-----ASEQARQLESEREALQQQHSVQVDQL---- 202
+++E Q+R+E +E +A E RA S+ AR+LE E L++ Q+
Sbjct: 1111 KIKELQARIEELEEEIEA-EHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNK 1169
Query: 203 -------RMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDN--HIKSSVVGSE 253
+M+ EA L+ E AA+ K++ + +L ++ DN +K + +
Sbjct: 1170 KREAEFQKMRRDLEEATLQHEATAATLRKKQADSVA----ELGEQIDNLQRVKQKLEKEK 1225
Query: 254 RKRGMQLEDLKQQLQ-------QAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQAD 306
+ M+++D+ ++ E ++ ++K + EQ ++ + + KA+
Sbjct: 1226 SELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQ 1285
Query: 307 IYKADFQAERQARE----KLAEKKELLQEQLEQLQRE 339
+ + +E +L + K+ L +QLE+L+R+
Sbjct: 1286 TQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQ 1322
Score = 54.3 bits (129), Expect = 2e-07
Identities = 56/268 (20%), Positives = 115/268 (42%), Gaps = 13/268 (4%)
Query: 93 LMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGE 152
+ K ++ +L+ L ++K L+ Q + VE + Q+ + K ++ Q+ L +
Sbjct: 1263 IKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQ 1322
Query: 153 LQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAA 212
++E A Q+ EQ + + + LQ+ S ++ E
Sbjct: 1323 MEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETD 1382
Query: 213 LRMERQAASEEKRKLAQ-LQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAE 271
+ E K+KLAQ LQ A E N +S+ ++++ ++EDL + L+++
Sbjct: 1383 AIQRTEELEEAKKKLAQRLQEAEEN--TETANSKCASLEKTKQRLQGEVEDLMRDLERSH 1440
Query: 272 EA---LVAKQEVIDKL----KEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAE 324
A L KQ DK+ K++ ++ + +E + ++ + R A E++ +
Sbjct: 1441 TACATLDKKQRNFDKVLAEWKQKLDESQAELEAA---QKESRSLSTELFKMRNAYEEVVD 1497
Query: 325 KKELLQEQLEQLQREYSKLKASCQESAR 352
+ E L+ + + LQ E S L E+ +
Sbjct: 1498 QLETLRRENKNLQEEISDLTEQIAETGK 1525
Score = 52.0 bits (123), Expect = 1e-06
Identities = 63/333 (18%), Positives = 137/333 (41%), Gaps = 33/333 (9%)
Query: 51 LQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLE 110
L +EE + L + +S Q L ++ EEL + + K + Q +R + L +
Sbjct: 1291 LSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQ 1350
Query: 111 -------KLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGE-LQESQSRLEA 162
K +L+R +A EV + + A + + L + LQE++ E
Sbjct: 1351 YEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTET 1410
Query: 163 ATKECQALEGRARAASEQARQLESERE------ALQQQHSVQVDQLRMQGQSVEAALRME 216
A +C +LE + + L + E A + D++ + + + E
Sbjct: 1411 ANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAE 1470
Query: 217 RQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVA 276
+AA +E R L+ ++E + ++ ++ + ++ DL +Q+ + + L
Sbjct: 1471 LEAAQKESRSLSTELFKMRNAYEEVVDQLE-TLRRENKNLQEEISDLTEQIAETGKNLQE 1529
Query: 277 KQEVIDKLKEEAEQHKIVMETV---------PVLKAQADIYKADFQAERQAREKLAEKKE 327
++ +++E ++ +E V +L+ Q ++ + + +R+ EK
Sbjct: 1530 AEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEK------ 1583
Query: 328 LLQEQLEQLQREYSKLKASCQESARIEDMRKRH 360
E++EQL+R S+ A +S ++R R+
Sbjct: 1584 --DEEIEQLKRN-SQRAAEALQSVLDAEIRSRN 1613
Score = 48.9 bits (115), Expect = 8e-06
Identities = 55/297 (18%), Positives = 134/297 (45%), Gaps = 25/297 (8%)
Query: 58 NQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQ 117
N+++ + + + + + LH + R ++ +E +VER L+ +
Sbjct: 1637 NRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDL-----KEQLAIVERRNGLLLEELEE 1691
Query: 118 KEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQA-LEG---R 173
+ AL + E +R +Q D + + S L ++ +LEA +CQA +E
Sbjct: 1692 MKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQE 1751
Query: 174 ARAASEQARQ------LESEREALQQQHSVQVDQLRMQGQSVEAALR-----MERQAASE 222
+R A E+A++ + +E +Q S +++++ + L+ E+ A
Sbjct: 1752 SRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKG 1811
Query: 223 EKRKLAQLQVAYHQLFQEYDNHIK--SSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEV 280
K+++ +L+ +L E D K + + K +++++ Q ++ + ++ Q++
Sbjct: 1812 GKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDL 1871
Query: 281 IDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQ 337
+DKL+ + + +K E + QA+ + + + E+ AE+ ++ + Q+ +L+
Sbjct: 1872 VDKLQAKVKSYKRQAEEA---EEQANTQLSRCRRVQHELEEAAERADIAESQVNKLR 1925
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 70.1 bits (170), Expect = 4e-12
Identities = 75/335 (22%), Positives = 151/335 (45%), Gaps = 27/335 (8%)
Query: 45 QGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLV 104
Q + LQ+ E Q+ + +++ Q + EE Q + E E + EA ++
Sbjct: 855 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL----YAEAEEMR 910
Query: 105 ERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQS-----R 159
RL +K +L+ + +E + QQ+ ++ + Q+ L +L+E ++ +
Sbjct: 911 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 970
Query: 160 LEAATKECQA--LEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMER 217
LE T E + LE +Q +L ER+ L+++ S L + + + +++
Sbjct: 971 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 218 QAASEEKRKLAQLQVAY---HQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEAL 274
+ S +++L+V + QE + +K + G Q+ DL+ Q+ + + L
Sbjct: 1031 KHES----MISELEVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQIAELKMQL 1085
Query: 275 VAKQEVID----KLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQ 330
K+E + +L +E Q ++ + L+ + D +ER AR K ++K L
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1145
Query: 331 EQLEQLQREYSKLKASCQESARIEDMR-KRHVEVS 364
E+LE L+ E L+ + +A +++R KR EV+
Sbjct: 1146 EELEALKTE---LEDTLDSTATQQELRAKREQEVT 1177
Score = 62.8 bits (151), Expect = 6e-10
Identities = 75/345 (21%), Positives = 152/345 (44%), Gaps = 25/345 (7%)
Query: 24 QDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQ 83
++ L EE + L + + + L+ + + + + + ++L ER +L
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT-TN 1014
Query: 84 ASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALR-EVEHLKRCQQQMAED---- 138
++ EEK + K + + + + +L+++ +KE+ R E+E LKR + A D
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESM----ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070
Query: 139 KASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQ 198
A ++AQ+ L +L + + L+AA + A ++ R+LE LQ+ +
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 199 VDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHI---KSSVVGSERK 255
R + + + L E +A E +L + + + K ++ R
Sbjct: 1131 -RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 256 RGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAE 315
Q+++++Q+ QA E L + E + K +++K +E K AD+ + +
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE-----KENADL-AGELRVL 1243
Query: 316 RQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH 360
QA++++ KK+ L+ Q+++LQ K S E AR E K H
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQS-----KCSDGERARAELNDKVH 1283
Score = 60.5 bits (145), Expect = 3e-09
Identities = 72/331 (21%), Positives = 138/331 (41%), Gaps = 39/331 (11%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLK 115
+ QEL R+ + E++ QA E K L K +E + + RL +++ K
Sbjct: 1048 KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD-DEIAQK 1106
Query: 116 RQKEQALREVE-HLKRCQQQMAEDKAS--------------VKAQVTSLLGELQESQSRL 160
+ +RE+E H+ Q+ + ++A+ ++A T L L + ++
Sbjct: 1107 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1166
Query: 161 EAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAA---LRMER 217
E K Q + +A E+ R E++ + ++Q+H+ V++L Q + + A L +
Sbjct: 1167 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1226
Query: 218 QAASEEKRKLA-QLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVA 276
Q +E LA +L+V K V ++K Q+++L+ + E A
Sbjct: 1227 QTLEKENADLAGELRVL---------GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 277 KQEVIDKLKEEAEQHKIVMETVP--VLKAQADIYKADFQAERQAREKLAEKKELLQEQLE 334
+ + KL+ E E ++ +K D+ Q L + +ELLQE+
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ--------LQDTQELLQEETR 1329
Query: 335 QLQREYSKLKASCQESARIEDMRKRHVEVSQ 365
Q +KL+ +E ++D +E Q
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360
Score = 59.7 bits (143), Expect = 5e-09
Identities = 68/326 (20%), Positives = 138/326 (42%), Gaps = 37/326 (11%)
Query: 45 QGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEK--EFLMCKFQEARK 102
+G E +++ + +++D R+ R E + ++++ K E + + QE
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1697
Query: 103 LVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEA 162
ER ++ DL +KE+ E+ + + ++K ++A++ L EL+E Q +EA
Sbjct: 1698 AAER-ARKQADL--EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754
Query: 163 ATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASE 222
+ R R A++QA QL +E + R Q E+A + + E
Sbjct: 1755 -------MSDRVRKATQQAEQLSNE-----------LATERSTAQKNESARQQLERQNKE 1796
Query: 223 EKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVID 282
+ KL +++ A F KS++ E K + Q +Q E+ KQ
Sbjct: 1797 LRSKLHEMEGAVKSKF-------KSTIAALEAK-------IAQLEEQVEQEAREKQAATK 1842
Query: 283 KLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSK 342
LK++ ++ K ++ V + A+ YK + ++L + E +E+ +++ K
Sbjct: 1843 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902
Query: 343 LKASCQESARIEDMRKRHVEVSQAPL 368
L+ E+ + R V ++ L
Sbjct: 1903 LQRELDEATESNEAMGREVNALKSKL 1928
Score = 58.2 bits (139), Expect = 1e-08
Identities = 73/314 (23%), Positives = 141/314 (44%), Gaps = 41/314 (13%)
Query: 73 RERCEELLHFQASQREEKEFLMCKFQE----ARKLVER----LGLEKLDLKRQKEQALRE 124
R+R E +A ++E K + + E A++ +ER L E DL K+ +
Sbjct: 1471 RDRAEA----EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 125 VEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQL 184
V L++ ++ + +K Q+ L ELQ ++ QAL+G Q
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG----------QF 1576
Query: 185 ESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNH 244
E + +A +Q+ + QL+ Q E L ER+ + +L+ L + D+
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1636
Query: 245 IK--SSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLK 302
IK + RK Q++D +++L E+A ++ E+ KE ++ K + +++
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQREL---EDARASRDEIFATAKENEKKAKSL--EADLMQ 1691
Query: 303 AQADIYKADFQAERQA---REKLAEK-------KELLQEQLEQLQREYSKLKASC-QESA 351
Q D+ A+ +A +QA +E+LAE+ + LQ++ +L+ ++L+ +E
Sbjct: 1692 LQEDLAAAE-RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750
Query: 352 RIEDMRKRHVEVSQ 365
+E M R + +Q
Sbjct: 1751 NMEAMSDRVRKATQ 1764
Score = 56.2 bits (134), Expect = 5e-08
Identities = 84/341 (24%), Positives = 149/341 (43%), Gaps = 58/341 (17%)
Query: 59 QELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQK 118
QE+R Q+ + L E+ E+ +A+ + K+ L + + + LG K +++ +K
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1254
Query: 119 EQALREVEHLK------------------RCQQQM---------AEDKASVKAQ-VTSLL 150
++ +V+ L+ + Q ++ AE KA A+ V SL
Sbjct: 1255 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314
Query: 151 GELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVE 210
+LQ++Q L+ T++ S + RQLE ER +LQ Q+D+ Q++E
Sbjct: 1315 SQLQDTQELLQEETRQ-------KLNVSTKLRQLEEERNSLQD----QLDEEMEAKQNLE 1363
Query: 211 AALRMERQAASEEKRKL---AQLQVAYHQLFQEYDNHIKSSVVGSERKRGM--QLEDLKQ 265
+ S+ K+KL A A + + + I++ E K +LE K
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 266 QLQQAEEALVA-----KQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQARE 320
+LQQ + LV +Q V + K++ + +++ E + AD + D +AE +ARE
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD--ERD-RAEAEARE 1480
Query: 321 K------LAEKKELLQEQLEQLQREYSKLKASCQESARIED 355
K LA E E E+L+R LKA ++ +D
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1521
Score = 48.9 bits (115), Expect = 8e-06
Identities = 44/194 (22%), Positives = 96/194 (49%), Gaps = 18/194 (9%)
Query: 165 KECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEK 224
+E QA E + E+ ++ E+E + L+Q+HS ++ + + ++A E A +EE
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA--ETELYAEAEEM 909
Query: 225 R-KLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDK 283
R +LA + ++ E + ++ E RG QL+ ++++ Q L + E
Sbjct: 910 RVRLAAKKQELEEILHEMEARLE-----EEEDRGQQLQAERKKMAQQMLDLEEQLE---- 960
Query: 284 LKEEAEQHKIVMETVPVLKAQADIYKADFQ--AERQAREKLAEKKELLQEQLEQLQREYS 341
+EEA + K+ +E V A+A I K + + KL+++++LL+E++ L +
Sbjct: 961 -EEEAARQKLQLEKV---TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016
Query: 342 KLKASCQESARIED 355
+ + + ++++
Sbjct: 1017 EEEEKAKNLTKLKN 1030
Score = 32.7 bits (73), Expect = 0.63
Identities = 21/101 (20%), Positives = 52/101 (51%), Gaps = 3/101 (2%)
Query: 259 QLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQA 318
Q E+++ + + ++ +Q+ ++LKE ++H + E +L+ Q + +
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909
Query: 319 REKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKR 359
R +LA KK+ L+E L +++ ++L+ +++ RK+
Sbjct: 910 RVRLAAKKQELEEILHEME---ARLEEEEDRGQQLQAERKK 947
Score = 30.4 bits (67), Expect = 3.1
Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 27/94 (28%)
Query: 266 QLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEK 325
Q+ + EE + AK++ + K KE + KA+ ++ + + Q +L E+
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQ------------KAENELKELE-----QKHSQLTEE 888
Query: 326 KELLQEQLEQLQREYSKLKASCQESARIEDMRKR 359
K LLQEQL+ A + A E+MR R
Sbjct: 889 KNLLQEQLQ----------AETELYAEAEEMRVR 912
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 70.1 bits (170), Expect = 4e-12
Identities = 75/335 (22%), Positives = 151/335 (45%), Gaps = 27/335 (8%)
Query: 45 QGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLV 104
Q + LQ+ E Q+ + +++ Q + EE Q + E E + EA ++
Sbjct: 862 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL----YAEAEEMR 917
Query: 105 ERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQS-----R 159
RL +K +L+ + +E + QQ+ ++ + Q+ L +L+E ++ +
Sbjct: 918 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977
Query: 160 LEAATKECQA--LEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMER 217
LE T E + LE +Q +L ER+ L+++ S L + + + +++
Sbjct: 978 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 218 QAASEEKRKLAQLQVAY---HQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEAL 274
+ S +++L+V + QE + +K + G Q+ DL+ Q+ + + L
Sbjct: 1038 KHES----MISELEVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQIAELKMQL 1092
Query: 275 VAKQEVID----KLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQ 330
K+E + +L +E Q ++ + L+ + D +ER AR K ++K L
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1152
Query: 331 EQLEQLQREYSKLKASCQESARIEDMR-KRHVEVS 364
E+LE L+ E L+ + +A +++R KR EV+
Sbjct: 1153 EELEALKTE---LEDTLDSTATQQELRAKREQEVT 1184
Score = 62.8 bits (151), Expect = 6e-10
Identities = 75/345 (21%), Positives = 152/345 (44%), Gaps = 25/345 (7%)
Query: 24 QDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQ 83
++ L EE + L + + + L+ + + + + + ++L ER +L
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT-TN 1021
Query: 84 ASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALR-EVEHLKRCQQQMAED---- 138
++ EEK + K + + + + +L+++ +KE+ R E+E LKR + A D
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESM----ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077
Query: 139 KASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQ 198
A ++AQ+ L +L + + L+AA + A ++ R+LE LQ+ +
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 199 VDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHI---KSSVVGSERK 255
R + + + L E +A E +L + + + K ++ R
Sbjct: 1138 -RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 256 RGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAE 315
Q+++++Q+ QA E L + E + K +++K +E K AD+ + +
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE-----KENADL-AGELRVL 1250
Query: 316 RQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH 360
QA++++ KK+ L+ Q+++LQ K S E AR E K H
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQS-----KCSDGERARAELNDKVH 1290
Score = 60.5 bits (145), Expect = 3e-09
Identities = 72/331 (21%), Positives = 138/331 (41%), Gaps = 39/331 (11%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLK 115
+ QEL R+ + E++ QA E K L K +E + + RL +++ K
Sbjct: 1055 KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD-DEIAQK 1113
Query: 116 RQKEQALREVE-HLKRCQQQMAEDKAS--------------VKAQVTSLLGELQESQSRL 160
+ +RE+E H+ Q+ + ++A+ ++A T L L + ++
Sbjct: 1114 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1173
Query: 161 EAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAA---LRMER 217
E K Q + +A E+ R E++ + ++Q+H+ V++L Q + + A L +
Sbjct: 1174 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1233
Query: 218 QAASEEKRKLA-QLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVA 276
Q +E LA +L+V K V ++K Q+++L+ + E A
Sbjct: 1234 QTLEKENADLAGELRVL---------GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 277 KQEVIDKLKEEAEQHKIVMETVP--VLKAQADIYKADFQAERQAREKLAEKKELLQEQLE 334
+ + KL+ E E ++ +K D+ Q L + +ELLQE+
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ--------LQDTQELLQEETR 1336
Query: 335 QLQREYSKLKASCQESARIEDMRKRHVEVSQ 365
Q +KL+ +E ++D +E Q
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367
Score = 59.7 bits (143), Expect = 5e-09
Identities = 68/326 (20%), Positives = 138/326 (42%), Gaps = 37/326 (11%)
Query: 45 QGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEK--EFLMCKFQEARK 102
+G E +++ + +++D R+ R E + ++++ K E + + QE
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704
Query: 103 LVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEA 162
ER ++ DL +KE+ E+ + + ++K ++A++ L EL+E Q +EA
Sbjct: 1705 AAER-ARKQADL--EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761
Query: 163 ATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASE 222
+ R R A++QA QL +E + R Q E+A + + E
Sbjct: 1762 -------MSDRVRKATQQAEQLSNE-----------LATERSTAQKNESARQQLERQNKE 1803
Query: 223 EKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVID 282
+ KL +++ A F KS++ E K + Q +Q E+ KQ
Sbjct: 1804 LRSKLHEMEGAVKSKF-------KSTIAALEAK-------IAQLEEQVEQEAREKQAATK 1849
Query: 283 KLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSK 342
LK++ ++ K ++ V + A+ YK + ++L + E +E+ +++ K
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909
Query: 343 LKASCQESARIEDMRKRHVEVSQAPL 368
L+ E+ + R V ++ L
Sbjct: 1910 LQRELDEATESNEAMGREVNALKSKL 1935
Score = 58.2 bits (139), Expect = 1e-08
Identities = 73/314 (23%), Positives = 141/314 (44%), Gaps = 41/314 (13%)
Query: 73 RERCEELLHFQASQREEKEFLMCKFQE----ARKLVER----LGLEKLDLKRQKEQALRE 124
R+R E +A ++E K + + E A++ +ER L E DL K+ +
Sbjct: 1478 RDRAEA----EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 125 VEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQL 184
V L++ ++ + +K Q+ L ELQ ++ QAL+G Q
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG----------QF 1583
Query: 185 ESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNH 244
E + +A +Q+ + QL+ Q E L ER+ + +L+ L + D+
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643
Query: 245 IK--SSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLK 302
IK + RK Q++D +++L E+A ++ E+ KE ++ K + +++
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQREL---EDARASRDEIFATAKENEKKAKSL--EADLMQ 1698
Query: 303 AQADIYKADFQAERQA---REKLAEK-------KELLQEQLEQLQREYSKLKASC-QESA 351
Q D+ A+ +A +QA +E+LAE+ + LQ++ +L+ ++L+ +E
Sbjct: 1699 LQEDLAAAE-RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757
Query: 352 RIEDMRKRHVEVSQ 365
+E M R + +Q
Sbjct: 1758 NMEAMSDRVRKATQ 1771
Score = 56.2 bits (134), Expect = 5e-08
Identities = 84/341 (24%), Positives = 149/341 (43%), Gaps = 58/341 (17%)
Query: 59 QELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQK 118
QE+R Q+ + L E+ E+ +A+ + K+ L + + + LG K +++ +K
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1261
Query: 119 EQALREVEHLK------------------RCQQQM---------AEDKASVKAQ-VTSLL 150
++ +V+ L+ + Q ++ AE KA A+ V SL
Sbjct: 1262 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321
Query: 151 GELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVE 210
+LQ++Q L+ T++ S + RQLE ER +LQ Q+D+ Q++E
Sbjct: 1322 SQLQDTQELLQEETRQ-------KLNVSTKLRQLEEERNSLQD----QLDEEMEAKQNLE 1370
Query: 211 AALRMERQAASEEKRKL---AQLQVAYHQLFQEYDNHIKSSVVGSERKRGM--QLEDLKQ 265
+ S+ K+KL A A + + + I++ E K +LE K
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 266 QLQQAEEALVA-----KQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQARE 320
+LQQ + LV +Q V + K++ + +++ E + AD + D +AE +ARE
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD--ERD-RAEAEARE 1487
Query: 321 K------LAEKKELLQEQLEQLQREYSKLKASCQESARIED 355
K LA E E E+L+R LKA ++ +D
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1528
Score = 48.9 bits (115), Expect = 8e-06
Identities = 44/194 (22%), Positives = 96/194 (49%), Gaps = 18/194 (9%)
Query: 165 KECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEK 224
+E QA E + E+ ++ E+E + L+Q+HS ++ + + ++A E A +EE
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA--ETELYAEAEEM 916
Query: 225 R-KLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDK 283
R +LA + ++ E + ++ E RG QL+ ++++ Q L + E
Sbjct: 917 RVRLAAKKQELEEILHEMEARLE-----EEEDRGQQLQAERKKMAQQMLDLEEQLE---- 967
Query: 284 LKEEAEQHKIVMETVPVLKAQADIYKADFQ--AERQAREKLAEKKELLQEQLEQLQREYS 341
+EEA + K+ +E V A+A I K + + KL+++++LL+E++ L +
Sbjct: 968 -EEEAARQKLQLEKV---TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023
Query: 342 KLKASCQESARIED 355
+ + + ++++
Sbjct: 1024 EEEEKAKNLTKLKN 1037
Score = 32.7 bits (73), Expect = 0.63
Identities = 21/101 (20%), Positives = 52/101 (51%), Gaps = 3/101 (2%)
Query: 259 QLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQA 318
Q E+++ + + ++ +Q+ ++LKE ++H + E +L+ Q + +
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 319 REKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKR 359
R +LA KK+ L+E L +++ ++L+ +++ RK+
Sbjct: 917 RVRLAAKKQELEEILHEME---ARLEEEEDRGQQLQAERKK 954
Score = 30.4 bits (67), Expect = 3.1
Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 27/94 (28%)
Query: 266 QLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEK 325
Q+ + EE + AK++ + K KE + KA+ ++ + + Q +L E+
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQ------------KAENELKELE-----QKHSQLTEE 895
Query: 326 KELLQEQLEQLQREYSKLKASCQESARIEDMRKR 359
K LLQEQL+ A + A E+MR R
Sbjct: 896 KNLLQEQLQ----------AETELYAEAEEMRVR 919
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.126 0.343
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,946,993
Number of Sequences: 37866
Number of extensions: 800601
Number of successful extensions: 14511
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 433
Number of HSP's successfully gapped in prelim test: 1053
Number of HSP's that attempted gapping in prelim test: 6218
Number of HSP's gapped (non-prelim): 4773
length of query: 419
length of database: 18,247,518
effective HSP length: 105
effective length of query: 314
effective length of database: 14,271,588
effective search space: 4481278632
effective search space used: 4481278632
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.