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Search of human proteins with 150456432
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|150456432 unc-51-like kinase 3 [Homo sapiens]
(472 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|150456432 unc-51-like kinase 3 [Homo sapiens] 931 0.0
gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 199 3e-51
gi|217330559 unc-51-like kinase 2 [Homo sapiens] 191 1e-48
gi|217330557 unc-51-like kinase 2 [Homo sapiens] 191 1e-48
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens] 169 4e-42
gi|38327570 serine/threonine protein kinase 6 [Homo sapiens] 169 4e-42
gi|38327568 serine/threonine protein kinase 6 [Homo sapiens] 169 4e-42
gi|38327566 serine/threonine protein kinase 6 [Homo sapiens] 169 4e-42
gi|38327564 serine/threonine protein kinase 6 [Homo sapiens] 169 4e-42
gi|38327562 serine/threonine protein kinase 6 [Homo sapiens] 169 4e-42
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 167 2e-41
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 165 7e-41
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 164 1e-40
gi|83776600 aurora kinase B [Homo sapiens] 162 8e-40
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 162 8e-40
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 161 1e-39
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 161 1e-39
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 161 1e-39
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 160 2e-39
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 160 2e-39
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 160 2e-39
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 160 2e-39
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 160 3e-39
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 160 3e-39
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 160 3e-39
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 160 3e-39
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 160 3e-39
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 159 4e-39
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 159 4e-39
gi|62865643 aurora kinase C isoform 3 [Homo sapiens] 159 5e-39
>gi|150456432 unc-51-like kinase 3 [Homo sapiens]
Length = 472
Score = 931 bits (2406), Expect = 0.0
Identities = 472/472 (100%), Positives = 472/472 (100%)
Query: 1 MAGPGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLL 60
MAGPGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLL
Sbjct: 1 MAGPGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLL 60
Query: 61 TEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQ 120
TEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQ
Sbjct: 61 TEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQ 120
Query: 121 LASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYM 180
LASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYM
Sbjct: 121 LASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYM 180
Query: 181 APEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLS 240
APEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLS
Sbjct: 181 APEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLS 240
Query: 241 RDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPSGESLGRATALVVQAVKKDQEGDS 300
RDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPSGESLGRATALVVQAVKKDQEGDS
Sbjct: 241 RDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPSGESLGRATALVVQAVKKDQEGDS 300
Query: 301 AAALSLYCKALDFFVPALHYEVDAQRKEAIKAKVGQYVSRAEELKAIVSSSNQALLRQGT 360
AAALSLYCKALDFFVPALHYEVDAQRKEAIKAKVGQYVSRAEELKAIVSSSNQALLRQGT
Sbjct: 301 AAALSLYCKALDFFVPALHYEVDAQRKEAIKAKVGQYVSRAEELKAIVSSSNQALLRQGT 360
Query: 361 SARDLLREMARDKPRLLAALEVASAAMAKEEAAGGEQDALDLYQHSLGELLLLLAAEPPG 420
SARDLLREMARDKPRLLAALEVASAAMAKEEAAGGEQDALDLYQHSLGELLLLLAAEPPG
Sbjct: 361 SARDLLREMARDKPRLLAALEVASAAMAKEEAAGGEQDALDLYQHSLGELLLLLAAEPPG 420
Query: 421 RRRELLHTEVQNLMARAEYLKEQVKMRESRWEADTLDKEGLSESVRSSCTLQ 472
RRRELLHTEVQNLMARAEYLKEQVKMRESRWEADTLDKEGLSESVRSSCTLQ
Sbjct: 421 RRRELLHTEVQNLMARAEYLKEQVKMRESRWEADTLDKEGLSESVRSSCTLQ 472
>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
Length = 1050
Score = 199 bits (507), Expect = 3e-51
Identities = 115/312 (36%), Positives = 179/312 (57%), Gaps = 16/312 (5%)
Query: 4 PGWGPPRLDG---FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLL 60
PG G G F + +G G +A V+K ++ VA+KC+ KK+L K+ L
Sbjct: 3 PGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTL-LG 61
Query: 61 TEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQ 120
EI+ILK ++H +IV L DFQ ++++YL+ME+C GGDL+ ++H R L E R+F+QQ
Sbjct: 62 KEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQ 121
Query: 121 LASALQFLHERNISHLDLKPQNILLS-------SLEKPHLKLADFGFAQHMSPWDEKHVL 173
+A A++ LH + I H DLKPQNILLS + +K+ADFGFA+++ L
Sbjct: 122 IAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATL 181
Query: 174 RGSPLYMAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIEL 233
GSP+YMAPE++ + YD + DLWS+G I+Y+ L G+ PF + S +L N+ +
Sbjct: 182 CGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVP 241
Query: 234 PLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPSGESLGRATALVVQAVK 293
+ S R LL LL+R+ R+ F +FF HP++D + S+ ++ + V +
Sbjct: 242 TIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLD-----ASPSVRKSPPVPVPSYP 296
Query: 294 KDQEGDSAAALS 305
G S+++ S
Sbjct: 297 SSGSGSSSSSSS 308
>gi|217330559 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 191 bits (485), Expect = 1e-48
Identities = 102/259 (39%), Positives = 162/259 (62%), Gaps = 8/259 (3%)
Query: 20 LGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKD 79
+G G +A V++ ++ T VAIK + KK+L+K+ + L EI+ILK ++H +IV L D
Sbjct: 15 VGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKILKELQHENIVALYD 73
Query: 80 FQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLK 139
Q ++++L+ME+C GGDL+ ++ + L E RVF+ Q+A+A++ LH + I H DLK
Sbjct: 74 VQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLK 133
Query: 140 PQNILLS-------SLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQYDA 192
PQNILLS S+ +K+ADFGFA+++ L GSP+YMAPE++ + YDA
Sbjct: 134 PQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDA 193
Query: 193 RVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQRLLE 252
+ DLWS+G ++Y+ L G+PPF + S +L NR + + S +LL LL+
Sbjct: 194 KADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQ 253
Query: 253 RDPSRRISFQDFFAHPWVD 271
R+ R+ F+ FF+HP+++
Sbjct: 254 RNQKDRMDFEAFFSHPFLE 272
>gi|217330557 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 191 bits (485), Expect = 1e-48
Identities = 102/259 (39%), Positives = 162/259 (62%), Gaps = 8/259 (3%)
Query: 20 LGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKD 79
+G G +A V++ ++ T VAIK + KK+L+K+ + L EI+ILK ++H +IV L D
Sbjct: 15 VGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKILKELQHENIVALYD 73
Query: 80 FQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLK 139
Q ++++L+ME+C GGDL+ ++ + L E RVF+ Q+A+A++ LH + I H DLK
Sbjct: 74 VQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLK 133
Query: 140 PQNILLS-------SLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQYDA 192
PQNILLS S+ +K+ADFGFA+++ L GSP+YMAPE++ + YDA
Sbjct: 134 PQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDA 193
Query: 193 RVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQRLLE 252
+ DLWS+G ++Y+ L G+PPF + S +L NR + + S +LL LL+
Sbjct: 194 KADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQ 253
Query: 253 RDPSRRISFQDFFAHPWVD 271
R+ R+ F+ FF+HP+++
Sbjct: 254 RNQKDRMDFEAFFSHPFLE 272
>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 169 bits (429), Expect = 4e-42
Identities = 92/261 (35%), Positives = 155/261 (59%), Gaps = 8/261 (3%)
Query: 11 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLT-EIEILKGI 69
L+ F + LG G + VY A +K ++ ++A+K + K L KA VE+ L E+EI +
Sbjct: 130 LEDFEIGRPLGKGKFGNVYLA-REKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHL 188
Query: 70 RHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLH 129
RHP+I++L + D+ +YLI+E+ G + R + E+ ++ +LA+AL + H
Sbjct: 189 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCH 248
Query: 130 ERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQ 189
+ + H D+KP+N+LL S + LK+ADFG++ H +P + L G+ Y+ PEM+ R
Sbjct: 249 SKRVIHRDIKPENLLLGSAGE--LKIADFGWSVH-APSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 190 YDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQR 249
+D +VDLWS+GV+ YE L G+PPF + ++ E ++I +E ++ RDL+ R
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISR---VEFTFPDFVTEGARDLISR 362
Query: 250 LLERDPSRRISFQDFFAHPWV 270
LL+ +PS+R ++ HPW+
Sbjct: 363 LLKHNPSQRPMLREVLEHPWI 383
>gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 169 bits (429), Expect = 4e-42
Identities = 92/261 (35%), Positives = 155/261 (59%), Gaps = 8/261 (3%)
Query: 11 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLT-EIEILKGI 69
L+ F + LG G + VY A +K ++ ++A+K + K L KA VE+ L E+EI +
Sbjct: 130 LEDFEIGRPLGKGKFGNVYLA-REKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHL 188
Query: 70 RHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLH 129
RHP+I++L + D+ +YLI+E+ G + R + E+ ++ +LA+AL + H
Sbjct: 189 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCH 248
Query: 130 ERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQ 189
+ + H D+KP+N+LL S + LK+ADFG++ H +P + L G+ Y+ PEM+ R
Sbjct: 249 SKRVIHRDIKPENLLLGSAGE--LKIADFGWSVH-APSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 190 YDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQR 249
+D +VDLWS+GV+ YE L G+PPF + ++ E ++I +E ++ RDL+ R
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISR---VEFTFPDFVTEGARDLISR 362
Query: 250 LLERDPSRRISFQDFFAHPWV 270
LL+ +PS+R ++ HPW+
Sbjct: 363 LLKHNPSQRPMLREVLEHPWI 383
>gi|38327568 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 169 bits (429), Expect = 4e-42
Identities = 92/261 (35%), Positives = 155/261 (59%), Gaps = 8/261 (3%)
Query: 11 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLT-EIEILKGI 69
L+ F + LG G + VY A +K ++ ++A+K + K L KA VE+ L E+EI +
Sbjct: 130 LEDFEIGRPLGKGKFGNVYLA-REKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHL 188
Query: 70 RHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLH 129
RHP+I++L + D+ +YLI+E+ G + R + E+ ++ +LA+AL + H
Sbjct: 189 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCH 248
Query: 130 ERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQ 189
+ + H D+KP+N+LL S + LK+ADFG++ H +P + L G+ Y+ PEM+ R
Sbjct: 249 SKRVIHRDIKPENLLLGSAGE--LKIADFGWSVH-APSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 190 YDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQR 249
+D +VDLWS+GV+ YE L G+PPF + ++ E ++I +E ++ RDL+ R
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISR---VEFTFPDFVTEGARDLISR 362
Query: 250 LLERDPSRRISFQDFFAHPWV 270
LL+ +PS+R ++ HPW+
Sbjct: 363 LLKHNPSQRPMLREVLEHPWI 383
>gi|38327566 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 169 bits (429), Expect = 4e-42
Identities = 92/261 (35%), Positives = 155/261 (59%), Gaps = 8/261 (3%)
Query: 11 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLT-EIEILKGI 69
L+ F + LG G + VY A +K ++ ++A+K + K L KA VE+ L E+EI +
Sbjct: 130 LEDFEIGRPLGKGKFGNVYLA-REKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHL 188
Query: 70 RHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLH 129
RHP+I++L + D+ +YLI+E+ G + R + E+ ++ +LA+AL + H
Sbjct: 189 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCH 248
Query: 130 ERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQ 189
+ + H D+KP+N+LL S + LK+ADFG++ H +P + L G+ Y+ PEM+ R
Sbjct: 249 SKRVIHRDIKPENLLLGSAGE--LKIADFGWSVH-APSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 190 YDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQR 249
+D +VDLWS+GV+ YE L G+PPF + ++ E ++I +E ++ RDL+ R
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISR---VEFTFPDFVTEGARDLISR 362
Query: 250 LLERDPSRRISFQDFFAHPWV 270
LL+ +PS+R ++ HPW+
Sbjct: 363 LLKHNPSQRPMLREVLEHPWI 383
>gi|38327564 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 169 bits (429), Expect = 4e-42
Identities = 92/261 (35%), Positives = 155/261 (59%), Gaps = 8/261 (3%)
Query: 11 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLT-EIEILKGI 69
L+ F + LG G + VY A +K ++ ++A+K + K L KA VE+ L E+EI +
Sbjct: 130 LEDFEIGRPLGKGKFGNVYLA-REKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHL 188
Query: 70 RHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLH 129
RHP+I++L + D+ +YLI+E+ G + R + E+ ++ +LA+AL + H
Sbjct: 189 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCH 248
Query: 130 ERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQ 189
+ + H D+KP+N+LL S + LK+ADFG++ H +P + L G+ Y+ PEM+ R
Sbjct: 249 SKRVIHRDIKPENLLLGSAGE--LKIADFGWSVH-APSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 190 YDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQR 249
+D +VDLWS+GV+ YE L G+PPF + ++ E ++I +E ++ RDL+ R
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISR---VEFTFPDFVTEGARDLISR 362
Query: 250 LLERDPSRRISFQDFFAHPWV 270
LL+ +PS+R ++ HPW+
Sbjct: 363 LLKHNPSQRPMLREVLEHPWI 383
>gi|38327562 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 169 bits (429), Expect = 4e-42
Identities = 92/261 (35%), Positives = 155/261 (59%), Gaps = 8/261 (3%)
Query: 11 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLT-EIEILKGI 69
L+ F + LG G + VY A +K ++ ++A+K + K L KA VE+ L E+EI +
Sbjct: 130 LEDFEIGRPLGKGKFGNVYLA-REKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHL 188
Query: 70 RHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLH 129
RHP+I++L + D+ +YLI+E+ G + R + E+ ++ +LA+AL + H
Sbjct: 189 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCH 248
Query: 130 ERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQ 189
+ + H D+KP+N+LL S + LK+ADFG++ H +P + L G+ Y+ PEM+ R
Sbjct: 249 SKRVIHRDIKPENLLLGSAGE--LKIADFGWSVH-APSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 190 YDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQR 249
+D +VDLWS+GV+ YE L G+PPF + ++ E ++I +E ++ RDL+ R
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISR---VEFTFPDFVTEGARDLISR 362
Query: 250 LLERDPSRRISFQDFFAHPWV 270
LL+ +PS+R ++ HPW+
Sbjct: 363 LLKHNPSQRPMLREVLEHPWI 383
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 167 bits (423), Expect = 2e-41
Identities = 104/279 (37%), Positives = 163/279 (58%), Gaps = 16/279 (5%)
Query: 11 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIR 70
++ + + E +G G++ VYK +K + +VVA+K + K ++ + NL EIEI++G+R
Sbjct: 1 MEKYHVLEMIGEGSFGRVYKG-RRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLR 59
Query: 71 HPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHE 130
HP+IV + D +++D +++ A G+L + + LPE + QL SAL +LH
Sbjct: 60 HPNIVHMLD-SFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHS 118
Query: 131 RNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHV-LRGSPLYMAPEMVCQRQ 189
I H D+KPQNILL+ + +KL DFGFA+ MS ++G+PLYM+PE+V +R
Sbjct: 119 HRILHRDMKPQNILLA--KGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERP 176
Query: 190 YDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLR-PLLSRDC-RDLL 247
YD DLWS+G ILYE G PPF + S +L + +++ P+R P C ++ L
Sbjct: 177 YDHTADLWSVGCILYELAVGTPPFYATSIFQL-----VSLILKDPVRWPSTISPCFKNFL 231
Query: 248 QRLLERDPSRRISFQDFFAHPW----VDLEHMPSGESLG 282
Q LL +DP +R+S+ D HP+ V + P+G LG
Sbjct: 232 QGLLTKDPRQRLSWPDLLYHPFIAGHVTIITEPAGPDLG 270
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 165 bits (418), Expect = 7e-41
Identities = 98/264 (37%), Positives = 155/264 (58%), Gaps = 14/264 (5%)
Query: 14 FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKK-SLNKASVENLLTEIEILKGIRHP 72
FI E LGSG ++ V+ ++ T ++ A+KC+ K + +S+EN EI +LK I+H
Sbjct: 23 FIFMEVLGSGAFSEVFLV-KQRLTGKLFALKCIKKSPAFRDSSLEN---EIAVLKKIKHE 78
Query: 73 HIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERN 132
+IV L+D + + YL+M+ +GG+L I R + EK A + +QQ+ SA+++LHE
Sbjct: 79 NIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENG 138
Query: 133 ISHLDLKPQNIL-LSSLEKPHLKLADFGFAQHMSPWDEKHVLR---GSPLYMAPEMVCQR 188
I H DLKP+N+L L+ E + + DFG +S ++ ++ G+P Y+APE++ Q+
Sbjct: 139 IVHRDLKPENLLYLTPEENSKIMITDFG----LSKMEQNGIMSTACGTPGYVAPEVLAQK 194
Query: 189 QYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRV-IELPLRPLLSRDCRDLL 247
Y VD WS+GVI Y L G PPF + S+L EKI+ E P +S +D +
Sbjct: 195 PYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFI 254
Query: 248 QRLLERDPSRRISFQDFFAHPWVD 271
LLE+DP+ R + + +HPW+D
Sbjct: 255 CHLLEKDPNERYTCEKALSHPWID 278
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 164 bits (416), Expect = 1e-40
Identities = 92/274 (33%), Positives = 155/274 (56%), Gaps = 9/274 (3%)
Query: 9 PRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKG 68
P + + L +G G +A V A REV AIK + K LN +S++ L E+ I+KG
Sbjct: 54 PHVGNYRLLRTIGKGNFAKVKLARHILTGREV-AIKIIDKTQLNPSSLQKLFREVRIMKG 112
Query: 69 IRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFL 128
+ HP+IV+L + +YL+ME+ + G++ ++ + + EK AR +Q+ SA+ +
Sbjct: 113 LNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYC 172
Query: 129 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQR 188
H++NI H DLK +N+LL + + ++K+ADFGF+ + + GSP Y APE+ +
Sbjct: 173 HQKNIVHRDLKAENLLLDA--EANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGK 230
Query: 189 QYDA-RVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLL 247
+YD VD+WS+GVILY + G PF + EL E++ + +P +S DC +L
Sbjct: 231 KYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGK-YRVPF--YMSTDCESIL 287
Query: 248 QRLLERDPSRRISFQDFFAHPWVDLEHMPSGESL 281
+R L +P++R + + W+++ + GE L
Sbjct: 288 RRFLVLNPAKRCTLEQIMKDKWINIGY--EGEEL 319
>gi|83776600 aurora kinase B [Homo sapiens]
Length = 344
Score = 162 bits (409), Expect = 8e-40
Identities = 93/261 (35%), Positives = 147/261 (56%), Gaps = 8/261 (3%)
Query: 11 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLT-EIEILKGI 69
+D F + LG G + VY A KK + +VA+K + K + K VE+ L EIEI +
Sbjct: 74 IDDFEIGRPLGKGKFGNVYLAREKK-SHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHL 132
Query: 70 RHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLH 129
HP+I++L ++ +D IYLI+E+ G+L + + E+ M++LA AL + H
Sbjct: 133 HHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCH 192
Query: 130 ERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQ 189
+ + H D+KP+N+LL K LK+ADFG++ H +P + + G+ Y+ PEM+ R
Sbjct: 193 GKKVIHRDIKPENLLLGL--KGELKIADFGWSVH-APSLRRKTMCGTLDYLPPEMIEGRM 249
Query: 190 YDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQR 249
++ +VDLW +GV+ YE L G PPF S S +E +I ++L + +DL+ +
Sbjct: 250 HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVK---VDLKFPASVPMGAQDLISK 306
Query: 250 LLERDPSRRISFQDFFAHPWV 270
LL +PS R+ AHPWV
Sbjct: 307 LLRHNPSERLPLAQVSAHPWV 327
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 162 bits (409), Expect = 8e-40
Identities = 91/267 (34%), Positives = 152/267 (56%), Gaps = 7/267 (2%)
Query: 9 PRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKG 68
P + + L + +G G +A V A REV A+K + K LN S++ L E+ I+K
Sbjct: 55 PHIGNYRLQKTIGKGNFAKVKLARHVLTGREV-AVKIIDKTQLNPTSLQKLFREVRIMKI 113
Query: 69 IRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFL 128
+ HP+IV+L + +YL+ME+ +GG++ ++ + EK AR +Q+ SA+Q+
Sbjct: 114 LNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 173
Query: 129 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQR 188
H++ I H DLK +N+LL ++K+ADFGF+ + ++ GSP Y APE+ +
Sbjct: 174 HQKYIVHRDLKAENLLLDG--DMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGK 231
Query: 189 QYDA-RVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLL 247
+YD VD+WS+GVILY + G PF ++ EL E++ + +P +S DC +LL
Sbjct: 232 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGK-YRIPF--YMSTDCENLL 288
Query: 248 QRLLERDPSRRISFQDFFAHPWVDLEH 274
++LL +P +R S + W+++ H
Sbjct: 289 KKLLVLNPIKRGSLEQIMKDRWMNVGH 315
>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
Length = 586
Score = 161 bits (407), Expect = 1e-39
Identities = 99/276 (35%), Positives = 161/276 (58%), Gaps = 14/276 (5%)
Query: 12 DGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVE------NLLTEIEI 65
D +I+++ LGSG V A+ +K ++V AIK ++K+ S N+ TEIEI
Sbjct: 261 DEYIMSKTLGSGACGEVKLAFERKTCKKV-AIKIISKRKFAIGSAREADPALNVETEIEI 319
Query: 66 LKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASAL 125
LK + HP I+++K+F +D+++ Y+++E GG+L + + L E +++ Q+ A+
Sbjct: 320 LKKLNHPCIIKIKNF-FDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAV 378
Query: 126 QFLHERNISHLDLKPQNILLSSLEKPHL-KLADFGFAQHMSPWDEKHVLRGSPLYMAPEM 184
Q+LHE I H DLKP+N+LLSS E+ L K+ DFG ++ + L G+P Y+APE+
Sbjct: 379 QYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEV 438
Query: 185 ---VCQRQYDARVDLWSMGVILYEALFGQPPFAS-RSFSELEEKIRSNRVIELP-LRPLL 239
V Y+ VD WS+GVIL+ L G PPF+ R+ L+++I S + +P + +
Sbjct: 439 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 498
Query: 240 SRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHM 275
S DL+++LL DP R + ++ HPW+ E M
Sbjct: 499 SEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDM 534
>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
Length = 543
Score = 161 bits (407), Expect = 1e-39
Identities = 99/276 (35%), Positives = 161/276 (58%), Gaps = 14/276 (5%)
Query: 12 DGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVE------NLLTEIEI 65
D +I+++ LGSG V A+ +K ++V AIK ++K+ S N+ TEIEI
Sbjct: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKV-AIKIISKRKFAIGSAREADPALNVETEIEI 276
Query: 66 LKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASAL 125
LK + HP I+++K+F +D+++ Y+++E GG+L + + L E +++ Q+ A+
Sbjct: 277 LKKLNHPCIIKIKNF-FDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAV 335
Query: 126 QFLHERNISHLDLKPQNILLSSLEKPHL-KLADFGFAQHMSPWDEKHVLRGSPLYMAPEM 184
Q+LHE I H DLKP+N+LLSS E+ L K+ DFG ++ + L G+P Y+APE+
Sbjct: 336 QYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEV 395
Query: 185 ---VCQRQYDARVDLWSMGVILYEALFGQPPFAS-RSFSELEEKIRSNRVIELP-LRPLL 239
V Y+ VD WS+GVIL+ L G PPF+ R+ L+++I S + +P + +
Sbjct: 396 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 455
Query: 240 SRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHM 275
S DL+++LL DP R + ++ HPW+ E M
Sbjct: 456 SEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDM 491
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 161 bits (407), Expect = 1e-39
Identities = 96/274 (35%), Positives = 156/274 (56%), Gaps = 10/274 (3%)
Query: 3 GPGWGPPR--LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLN--KASVEN 58
GP W D + + LG+G ++ V A K+ T+++VAIKC+AK++L + S+EN
Sbjct: 7 GPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKR-TQKLVAIKCIAKEALEGKEGSMEN 65
Query: 59 LLTEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFM 118
EI +L I+HP+IV L D ++YLIM+ +GG+L I + E+ A +
Sbjct: 66 ---EIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLI 122
Query: 119 QQLASALQFLHERNISHLDLKPQNILLSSL-EKPHLKLADFGFAQHMSPWDEKHVLRGSP 177
Q+ A+++LH+ I H DLKP+N+L SL E + ++DFG ++ P G+P
Sbjct: 123 FQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTP 182
Query: 178 LYMAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKI-RSNRVIELPLR 236
Y+APE++ Q+ Y VD WS+GVI Y L G PPF + ++L E+I ++ + P
Sbjct: 183 GYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYW 242
Query: 237 PLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWV 270
+S +D ++ L+E+DP +R + + HPW+
Sbjct: 243 DDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 160 bits (405), Expect = 2e-39
Identities = 92/267 (34%), Positives = 150/267 (56%), Gaps = 7/267 (2%)
Query: 9 PRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKG 68
P + + L + +G G +A V A REV AIK + K LN S++ L E+ I+K
Sbjct: 51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREV-AIKIIDKTQLNPTSLQKLFREVRIMKI 109
Query: 69 IRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFL 128
+ HP+IV+L + +YLIME+ +GG++ ++ + EK AR +Q+ SA+Q+
Sbjct: 110 LNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169
Query: 129 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQR 188
H++ I H DLK +N+LL + ++K+ADFGF+ + + GSP Y APE+ +
Sbjct: 170 HQKRIVHRDLKAENLLLDA--DMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGK 227
Query: 189 QYDA-RVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLL 247
+YD VD+WS+GVILY + G PF ++ EL E++ + +P +S DC +LL
Sbjct: 228 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGK-YRIPF--YMSTDCENLL 284
Query: 248 QRLLERDPSRRISFQDFFAHPWVDLEH 274
+R L +P +R + + W++ H
Sbjct: 285 KRFLVLNPIKRGTLEQIMKDRWINAGH 311
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 160 bits (405), Expect = 2e-39
Identities = 92/267 (34%), Positives = 150/267 (56%), Gaps = 7/267 (2%)
Query: 9 PRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKG 68
P + + L + +G G +A V A REV AIK + K LN S++ L E+ I+K
Sbjct: 51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREV-AIKIIDKTQLNPTSLQKLFREVRIMKI 109
Query: 69 IRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFL 128
+ HP+IV+L + +YLIME+ +GG++ ++ + EK AR +Q+ SA+Q+
Sbjct: 110 LNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169
Query: 129 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQR 188
H++ I H DLK +N+LL + ++K+ADFGF+ + + GSP Y APE+ +
Sbjct: 170 HQKRIVHRDLKAENLLLDA--DMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGK 227
Query: 189 QYDA-RVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLL 247
+YD VD+WS+GVILY + G PF ++ EL E++ + +P +S DC +LL
Sbjct: 228 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGK-YRIPF--YMSTDCENLL 284
Query: 248 QRLLERDPSRRISFQDFFAHPWVDLEH 274
+R L +P +R + + W++ H
Sbjct: 285 KRFLVLNPIKRGTLEQIMKDRWINAGH 311
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 160 bits (405), Expect = 2e-39
Identities = 92/267 (34%), Positives = 150/267 (56%), Gaps = 7/267 (2%)
Query: 9 PRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKG 68
P + + L + +G G +A V A REV AIK + K LN S++ L E+ I+K
Sbjct: 51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREV-AIKIIDKTQLNPTSLQKLFREVRIMKI 109
Query: 69 IRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFL 128
+ HP+IV+L + +YLIME+ +GG++ ++ + EK AR +Q+ SA+Q+
Sbjct: 110 LNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169
Query: 129 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQR 188
H++ I H DLK +N+LL + ++K+ADFGF+ + + GSP Y APE+ +
Sbjct: 170 HQKRIVHRDLKAENLLLDA--DMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGK 227
Query: 189 QYDA-RVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLL 247
+YD VD+WS+GVILY + G PF ++ EL E++ + +P +S DC +LL
Sbjct: 228 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGK-YRIPF--YMSTDCENLL 284
Query: 248 QRLLERDPSRRISFQDFFAHPWVDLEH 274
+R L +P +R + + W++ H
Sbjct: 285 KRFLVLNPIKRGTLEQIMKDRWINAGH 311
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 160 bits (405), Expect = 2e-39
Identities = 92/267 (34%), Positives = 150/267 (56%), Gaps = 7/267 (2%)
Query: 9 PRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKG 68
P + + L + +G G +A V A REV AIK + K LN S++ L E+ I+K
Sbjct: 51 PHIGNYRLLKTIGKGNFAKVKLARHILTGREV-AIKIIDKTQLNPTSLQKLFREVRIMKI 109
Query: 69 IRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFL 128
+ HP+IV+L + +YLIME+ +GG++ ++ + EK AR +Q+ SA+Q+
Sbjct: 110 LNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169
Query: 129 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQR 188
H++ I H DLK +N+LL + ++K+ADFGF+ + + GSP Y APE+ +
Sbjct: 170 HQKRIVHRDLKAENLLLDA--DMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGK 227
Query: 189 QYDA-RVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLL 247
+YD VD+WS+GVILY + G PF ++ EL E++ + +P +S DC +LL
Sbjct: 228 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGK-YRIPF--YMSTDCENLL 284
Query: 248 QRLLERDPSRRISFQDFFAHPWVDLEH 274
+R L +P +R + + W++ H
Sbjct: 285 KRFLVLNPIKRGTLEQIMKDRWINAGH 311
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 160 bits (404), Expect = 3e-39
Identities = 89/267 (33%), Positives = 154/267 (57%), Gaps = 7/267 (2%)
Query: 9 PRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKG 68
P + + L + +G G +A V A +EV A+K + K LN +S++ L E+ I+K
Sbjct: 48 PHIGNYRLLKTIGKGNFAKVKLARHILTGKEV-AVKIIDKTQLNSSSLQKLFREVRIMKV 106
Query: 69 IRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFL 128
+ HP+IV+L + +YL+ME+ +GG++ ++ + EK AR +Q+ SA+Q+
Sbjct: 107 LNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 166
Query: 129 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQR 188
H++ I H DLK +N+LL + ++K+ADFGF+ + ++ GSP Y APE+ +
Sbjct: 167 HQKFIVHRDLKAENLLLDA--DMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGK 224
Query: 189 QYDA-RVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLL 247
+YD VD+WS+GVILY + G PF ++ EL E++ + +P +S DC +LL
Sbjct: 225 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGK-YRIPF--YMSTDCENLL 281
Query: 248 QRLLERDPSRRISFQDFFAHPWVDLEH 274
++ L +PS+R + + W+++ H
Sbjct: 282 KKFLILNPSKRGTLEQIMKDRWMNVGH 308
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 160 bits (404), Expect = 3e-39
Identities = 89/267 (33%), Positives = 154/267 (57%), Gaps = 7/267 (2%)
Query: 9 PRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKG 68
P + + L + +G G +A V A +EV A+K + K LN +S++ L E+ I+K
Sbjct: 48 PHIGNYRLLKTIGKGNFAKVKLARHILTGKEV-AVKIIDKTQLNSSSLQKLFREVRIMKV 106
Query: 69 IRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFL 128
+ HP+IV+L + +YL+ME+ +GG++ ++ + EK AR +Q+ SA+Q+
Sbjct: 107 LNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 166
Query: 129 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQR 188
H++ I H DLK +N+LL + ++K+ADFGF+ + ++ GSP Y APE+ +
Sbjct: 167 HQKFIVHRDLKAENLLLDA--DMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGK 224
Query: 189 QYDA-RVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLL 247
+YD VD+WS+GVILY + G PF ++ EL E++ + +P +S DC +LL
Sbjct: 225 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGK-YRIPF--YMSTDCENLL 281
Query: 248 QRLLERDPSRRISFQDFFAHPWVDLEH 274
++ L +PS+R + + W+++ H
Sbjct: 282 KKFLILNPSKRGTLEQIMKDRWMNVGH 308
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 160 bits (404), Expect = 3e-39
Identities = 89/267 (33%), Positives = 154/267 (57%), Gaps = 7/267 (2%)
Query: 9 PRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKG 68
P + + L + +G G +A V A +EV A+K + K LN +S++ L E+ I+K
Sbjct: 48 PHIGNYRLLKTIGKGNFAKVKLARHILTGKEV-AVKIIDKTQLNSSSLQKLFREVRIMKV 106
Query: 69 IRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFL 128
+ HP+IV+L + +YL+ME+ +GG++ ++ + EK AR +Q+ SA+Q+
Sbjct: 107 LNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 166
Query: 129 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQR 188
H++ I H DLK +N+LL + ++K+ADFGF+ + ++ GSP Y APE+ +
Sbjct: 167 HQKFIVHRDLKAENLLLDA--DMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGK 224
Query: 189 QYDA-RVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLL 247
+YD VD+WS+GVILY + G PF ++ EL E++ + +P +S DC +LL
Sbjct: 225 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGK-YRIPF--YMSTDCENLL 281
Query: 248 QRLLERDPSRRISFQDFFAHPWVDLEH 274
++ L +PS+R + + W+++ H
Sbjct: 282 KKFLILNPSKRGTLEQIMKDRWMNVGH 308
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 160 bits (404), Expect = 3e-39
Identities = 89/267 (33%), Positives = 154/267 (57%), Gaps = 7/267 (2%)
Query: 9 PRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKG 68
P + + L + +G G +A V A +EV A+K + K LN +S++ L E+ I+K
Sbjct: 48 PHIGNYRLLKTIGKGNFAKVKLARHILTGKEV-AVKIIDKTQLNSSSLQKLFREVRIMKV 106
Query: 69 IRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFL 128
+ HP+IV+L + +YL+ME+ +GG++ ++ + EK AR +Q+ SA+Q+
Sbjct: 107 LNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 166
Query: 129 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQR 188
H++ I H DLK +N+LL + ++K+ADFGF+ + ++ GSP Y APE+ +
Sbjct: 167 HQKFIVHRDLKAENLLLDA--DMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGK 224
Query: 189 QYDA-RVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLL 247
+YD VD+WS+GVILY + G PF ++ EL E++ + +P +S DC +LL
Sbjct: 225 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGK-YRIPF--YMSTDCENLL 281
Query: 248 QRLLERDPSRRISFQDFFAHPWVDLEH 274
++ L +PS+R + + W+++ H
Sbjct: 282 KKFLILNPSKRGTLEQIMKDRWMNVGH 308
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 160 bits (404), Expect = 3e-39
Identities = 89/267 (33%), Positives = 154/267 (57%), Gaps = 7/267 (2%)
Query: 9 PRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKG 68
P + + L + +G G +A V A +EV A+K + K LN +S++ L E+ I+K
Sbjct: 15 PHIGNYRLLKTIGKGNFAKVKLARHILTGKEV-AVKIIDKTQLNSSSLQKLFREVRIMKV 73
Query: 69 IRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFL 128
+ HP+IV+L + +YL+ME+ +GG++ ++ + EK AR +Q+ SA+Q+
Sbjct: 74 LNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 133
Query: 129 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQR 188
H++ I H DLK +N+LL + ++K+ADFGF+ + ++ GSP Y APE+ +
Sbjct: 134 HQKFIVHRDLKAENLLLDA--DMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGK 191
Query: 189 QYDA-RVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLL 247
+YD VD+WS+GVILY + G PF ++ EL E++ + +P +S DC +LL
Sbjct: 192 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGK-YRIPF--YMSTDCENLL 248
Query: 248 QRLLERDPSRRISFQDFFAHPWVDLEH 274
++ L +PS+R + + W+++ H
Sbjct: 249 KKFLILNPSKRGTLEQIMKDRWMNVGH 275
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 159 bits (403), Expect = 4e-39
Identities = 91/261 (34%), Positives = 152/261 (58%), Gaps = 8/261 (3%)
Query: 14 FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLN--KASVENLLTEIEILKGIRH 71
F E LG+G ++ V A +K T ++ A+KC+ KK+L ++S+EN EI +L+ I+H
Sbjct: 23 FEFKETLGTGAFSEVVLA-EEKATGKLFAVKCIPKKALKGKESSIEN---EIAVLRKIKH 78
Query: 72 PHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHER 131
+IV L+D +++YL+M+ +GG+L I + EK A ++Q+ A+ +LH
Sbjct: 79 ENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRM 138
Query: 132 NISHLDLKPQNIL-LSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQY 190
I H DLKP+N+L S E+ + ++DFG ++ D G+P Y+APE++ Q+ Y
Sbjct: 139 GIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPY 198
Query: 191 DARVDLWSMGVILYEALFGQPPFASRSFSELEEKI-RSNRVIELPLRPLLSRDCRDLLQR 249
VD WS+GVI Y L G PPF + S+L E+I ++ + P +S +D ++
Sbjct: 199 SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRN 258
Query: 250 LLERDPSRRISFQDFFAHPWV 270
L+E+DP++R + + HPW+
Sbjct: 259 LMEKDPNKRYTCEQAARHPWI 279
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 159 bits (403), Expect = 4e-39
Identities = 91/261 (34%), Positives = 152/261 (58%), Gaps = 8/261 (3%)
Query: 14 FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLN--KASVENLLTEIEILKGIRH 71
F E LG+G ++ V A +K T ++ A+KC+ KK+L ++S+EN EI +L+ I+H
Sbjct: 23 FEFKETLGTGAFSEVVLA-EEKATGKLFAVKCIPKKALKGKESSIEN---EIAVLRKIKH 78
Query: 72 PHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHER 131
+IV L+D +++YL+M+ +GG+L I + EK A ++Q+ A+ +LH
Sbjct: 79 ENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRM 138
Query: 132 NISHLDLKPQNIL-LSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQY 190
I H DLKP+N+L S E+ + ++DFG ++ D G+P Y+APE++ Q+ Y
Sbjct: 139 GIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPY 198
Query: 191 DARVDLWSMGVILYEALFGQPPFASRSFSELEEKI-RSNRVIELPLRPLLSRDCRDLLQR 249
VD WS+GVI Y L G PPF + S+L E+I ++ + P +S +D ++
Sbjct: 199 SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRN 258
Query: 250 LLERDPSRRISFQDFFAHPWV 270
L+E+DP++R + + HPW+
Sbjct: 259 LMEKDPNKRYTCEQAARHPWI 279
>gi|62865643 aurora kinase C isoform 3 [Homo sapiens]
Length = 275
Score = 159 bits (402), Expect = 5e-39
Identities = 93/263 (35%), Positives = 150/263 (57%), Gaps = 12/263 (4%)
Query: 11 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLT-EIEILKGI 69
+D F + LG G + VY A K ++ +VA+K + K + K +E+ L EIEI +
Sbjct: 6 VDDFEIGRPLGKGKFGNVYLARLK-ESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHL 64
Query: 70 RHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLH 129
+HP+I++L ++ D+ +YLI+E+ G+L + + L E+ +++LA AL + H
Sbjct: 65 QHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCH 124
Query: 130 ERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQ 189
++ + H D+KP+N+LL + +K+ADFG++ H +P + + G+ Y+ PEM+ R
Sbjct: 125 DKKVIHRDIKPENLLLGF--RGEVKIADFGWSVH-TPSLRRKTMCGTLDYLPPEMIEGRT 181
Query: 190 YDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSR--DCRDLL 247
YD +VDLW +GV+ YE L G PPF S S SE R++++ +R LS RDL+
Sbjct: 182 YDEKVDLWCIGVLCYELLVGYPPFESASHSE-----TYRRILKVDVRFPLSMPLGARDLI 236
Query: 248 QRLLERDPSRRISFQDFFAHPWV 270
RLL P R+ HPWV
Sbjct: 237 SRLLRYQPLERLPLAQILKHPWV 259
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,261,368
Number of Sequences: 37866
Number of extensions: 719338
Number of successful extensions: 4728
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 643
Number of HSP's successfully gapped in prelim test: 182
Number of HSP's that attempted gapping in prelim test: 2288
Number of HSP's gapped (non-prelim): 1093
length of query: 472
length of database: 18,247,518
effective HSP length: 106
effective length of query: 366
effective length of database: 14,233,722
effective search space: 5209542252
effective search space used: 5209542252
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.