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Search of human proteins with 150417984
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
sapiens]
(2146 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ... 4297 0.0
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa... 2052 0.0
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s... 1743 0.0
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform... 1258 0.0
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform... 1258 0.0
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor... 1021 0.0
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor... 1021 0.0
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13... 980 0.0
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s... 495 e-139
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s... 280 8e-75
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo... 277 7e-74
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ... 270 1e-71
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ... 270 1e-71
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s... 257 8e-68
gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sap... 224 5e-58
gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens] 155 4e-37
gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens] 155 4e-37
gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens] 155 4e-37
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 91 1e-17
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 86 5e-16
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 86 5e-16
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 86 5e-16
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 82 4e-15
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 81 1e-14
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7... 81 1e-14
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6... 81 1e-14
gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5... 81 1e-14
gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3... 81 1e-14
gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4... 81 1e-14
gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2... 81 1e-14
>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
sapiens]
Length = 2146
Score = 4297 bits (11145), Expect = 0.0
Identities = 2146/2146 (100%), Positives = 2146/2146 (100%)
Query: 1 MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKP 60
MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKP
Sbjct: 1 MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKP 60
Query: 61 LPSAGTVPWLQGLICNVNNTCFPQLTPGEEPGRLSNFNDSLVSRLLADARTVLGGASAHR 120
LPSAGTVPWLQGLICNVNNTCFPQLTPGEEPGRLSNFNDSLVSRLLADARTVLGGASAHR
Sbjct: 61 LPSAGTVPWLQGLICNVNNTCFPQLTPGEEPGRLSNFNDSLVSRLLADARTVLGGASAHR 120
Query: 121 TLAGLGKLIATLRAARSTAQPQPTKQSPLEPPMLDVAELLTSLLRTESLGLALGQAQEPL 180
TLAGLGKLIATLRAARSTAQPQPTKQSPLEPPMLDVAELLTSLLRTESLGLALGQAQEPL
Sbjct: 121 TLAGLGKLIATLRAARSTAQPQPTKQSPLEPPMLDVAELLTSLLRTESLGLALGQAQEPL 180
Query: 181 HSLLEAAEDLAQELLALRSLVELRALLQRPRGTSGPLELLSEALCSVRGPSSTVGPSLNW 240
HSLLEAAEDLAQELLALRSLVELRALLQRPRGTSGPLELLSEALCSVRGPSSTVGPSLNW
Sbjct: 181 HSLLEAAEDLAQELLALRSLVELRALLQRPRGTSGPLELLSEALCSVRGPSSTVGPSLNW 240
Query: 241 YEASDLMELVGQEPESALPDSSLSPACSELIGALDSHPLSRLLWRRLKPLILGKLLFAPD 300
YEASDLMELVGQEPESALPDSSLSPACSELIGALDSHPLSRLLWRRLKPLILGKLLFAPD
Sbjct: 241 YEASDLMELVGQEPESALPDSSLSPACSELIGALDSHPLSRLLWRRLKPLILGKLLFAPD 300
Query: 301 TPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPRIFTFMNDSSNVAMLQRLLQMQDEGRR 360
TPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPRIFTFMNDSSNVAMLQRLLQMQDEGRR
Sbjct: 301 TPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPRIFTFMNDSSNVAMLQRLLQMQDEGRR 360
Query: 361 QPRPGGRDHMEALRSFLDPGSGGYSWQDAHADVGHLVGTLGRVTECLSLDKLEAAPSEAA 420
QPRPGGRDHMEALRSFLDPGSGGYSWQDAHADVGHLVGTLGRVTECLSLDKLEAAPSEAA
Sbjct: 361 QPRPGGRDHMEALRSFLDPGSGGYSWQDAHADVGHLVGTLGRVTECLSLDKLEAAPSEAA 420
Query: 421 LVSRALQLLAEHRFWAGVVFLGPEDSSDPTEHPTPDLGPGHVRIKIRMDIDVVTRTNKIR 480
LVSRALQLLAEHRFWAGVVFLGPEDSSDPTEHPTPDLGPGHVRIKIRMDIDVVTRTNKIR
Sbjct: 421 LVSRALQLLAEHRFWAGVVFLGPEDSSDPTEHPTPDLGPGHVRIKIRMDIDVVTRTNKIR 480
Query: 481 DRFWDPGPAADPLTDLRYVWGGFVYLQDLVERAAVRVLSGANPRAGLYLQQMPYPCYVDD 540
DRFWDPGPAADPLTDLRYVWGGFVYLQDLVERAAVRVLSGANPRAGLYLQQMPYPCYVDD
Sbjct: 481 DRFWDPGPAADPLTDLRYVWGGFVYLQDLVERAAVRVLSGANPRAGLYLQQMPYPCYVDD 540
Query: 541 VFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCL 600
VFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCL
Sbjct: 541 VFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCL 600
Query: 601 GPFLLSAALLVLVLKLGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACG 660
GPFLLSAALLVLVLKLGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACG
Sbjct: 601 GPFLLSAALLVLVLKLGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACG 660
Query: 661 GLAYFSLYLPYVLCVAWRDRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVG 720
GLAYFSLYLPYVLCVAWRDRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVG
Sbjct: 661 GLAYFSLYLPYVLCVAWRDRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVG 720
Query: 721 TRPTADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPP 780
TRPTADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPP
Sbjct: 721 TRPTADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPP 780
Query: 781 KSPAPCPTPLDPKVLVEEAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFL 840
KSPAPCPTPLDPKVLVEEAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFL
Sbjct: 781 KSPAPCPTPLDPKVLVEEAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFL 840
Query: 841 GHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDE 900
GHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDE
Sbjct: 841 GHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDE 900
Query: 901 HVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQV 960
HVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQV
Sbjct: 901 HVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQV 960
Query: 961 VILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCG 1020
VILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCG
Sbjct: 961 VILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCG 1020
Query: 1021 SPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLA 1080
SPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLA
Sbjct: 1021 SPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLA 1080
Query: 1081 LVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLE 1140
LVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLE
Sbjct: 1081 LVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLE 1140
Query: 1141 EIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETD 1200
EIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETD
Sbjct: 1141 EIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETD 1200
Query: 1201 QGSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIV 1260
QGSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIV
Sbjct: 1201 QGSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIV 1260
Query: 1261 PPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFSA 1320
PPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFSA
Sbjct: 1261 PPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFSA 1320
Query: 1321 PEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQ 1380
PEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQ
Sbjct: 1321 PEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQ 1380
Query: 1381 NLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEELW 1440
NLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEELW
Sbjct: 1381 NLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEELW 1440
Query: 1441 ALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLP 1500
ALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLP
Sbjct: 1441 ALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLP 1500
Query: 1501 PGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIEE 1560
PGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIEE
Sbjct: 1501 PGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIEE 1560
Query: 1561 RVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPALL 1620
RVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPALL
Sbjct: 1561 RVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPALL 1620
Query: 1621 LLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQEV 1680
LLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQEV
Sbjct: 1621 LLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQEV 1680
Query: 1681 SRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQ 1740
SRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQ
Sbjct: 1681 SRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQ 1740
Query: 1741 GPLFLLFTLLLQHRSQLLPQPRVRSLPLLGEEDEDVARERERVVQGATQGDVLVLRNLTK 1800
GPLFLLFTLLLQHRSQLLPQPRVRSLPLLGEEDEDVARERERVVQGATQGDVLVLRNLTK
Sbjct: 1741 GPLFLLFTLLLQHRSQLLPQPRVRSLPLLGEEDEDVARERERVVQGATQGDVLVLRNLTK 1800
Query: 1801 VYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAR 1860
VYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAR
Sbjct: 1801 VYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAR 1860
Query: 1861 EPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYAD 1920
EPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYAD
Sbjct: 1861 EPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYAD 1920
Query: 1921 RPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVML 1980
RPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVML
Sbjct: 1921 RPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVML 1980
Query: 1981 TSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAA 2040
TSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAA
Sbjct: 1981 TSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAA 2040
Query: 2041 EFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYF 2100
EFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYF
Sbjct: 2041 EFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYF 2100
Query: 2101 SKDQGKDEDTEEQKEAGVGVDPAPGLQHPKRVSQFLDDPSTAETVL 2146
SKDQGKDEDTEEQKEAGVGVDPAPGLQHPKRVSQFLDDPSTAETVL
Sbjct: 2101 SKDQGKDEDTEEQKEAGVGVDPAPGLQHPKRVSQFLDDPSTAETVL 2146
>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
sapiens]
Length = 2261
Score = 2052 bits (5317), Expect = 0.0
Identities = 1052/2008 (52%), Positives = 1386/2008 (69%), Gaps = 62/2008 (3%)
Query: 158 ELLTSLLRT--ESLGLALGQAQEPLHSLLEAAEDLAQELLALRSLVELRA---LLQRPRG 212
++L +LRT + + E +LL + LAQEL ++RS ++R L
Sbjct: 234 DILKPILRTLNSTSPFPSKELAEATKTLLHSLGTLAQELFSMRSWSDMRQEVMFLTNVNS 293
Query: 213 TSGPLEL---LSEALCSVRGPSSTVGPSLNWYEASDLMELVG----QEPESALPDSSLSP 265
+S ++ +S +C SLNWYE ++ L G +E D+S +P
Sbjct: 294 SSSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETFYDNSTTP 353
Query: 266 ACSELIGALDSHPLSRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEELTLLRDVR 325
C++L+ L+S PLSR++W+ LKPL++GK+L+ PDTP TR++MA+VN+TF+EL + D+
Sbjct: 354 YCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLE 413
Query: 326 EVWEMLGPRIFTFMNDSSNVAMLQRLLQMQDEGR--RQPRPGGRDHMEALRSFLDP---- 379
+WE L P+I+TFM +S + +++ LL +D Q G + + +FL
Sbjct: 414 GMWEELSPKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPED 473
Query: 380 --GSGG--YSWQDAHADVGHLVGTLGRVTECLSLDKLEAAPSEAALVSRALQLLAEHRFW 435
S G Y+W++A + + T+ R EC++L+KLE +E L++++++LL E +FW
Sbjct: 474 VQSSNGSVYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMELLDERKFW 533
Query: 436 AGVVFLGPEDSSDPTEHPTPDLGPGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTD 495
AG+VF G S H HV+ KIRMDID V RTNKI+D +WDPGP ADP D
Sbjct: 534 AGIVFTGITPGSIELPH--------HVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFED 585
Query: 496 LRYVWGGFVYLQDLVERAAVRVLSGANPRAGLYLQQMPYPCYVDDVFLRVLSRSLPLFLT 555
+RYVWGGF YLQD+VE+A +RVL+G + G+Y+QQMPYPCYVDD+FLRV+SRS+PLF+T
Sbjct: 586 MRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMT 645
Query: 556 LAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLK 615
LAWIYSV + +K +V EKE RL++TMR MGL ++LW WF+S L P L+SA LLV++LK
Sbjct: 646 LAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILK 705
Query: 616 LGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCV 675
LG++LPYS P VVF+FL+ FAV T+ Q FL+S FSRANLAAACGG+ YF+LYLPYVLCV
Sbjct: 706 LGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCV 765
Query: 676 AWRDRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTA-DVFSLAQVS 734
AW+D + ++ ASLLSPVAFGFGCE AL EEQG G QW N+ P D F+L
Sbjct: 766 AWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSV 825
Query: 735 GLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPKSPAPCPTPLD-PK 793
++L D LYG+ TWY+EAV PGQYGIP PW FP +SYW G + P +
Sbjct: 826 SMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISE 885
Query: 794 VLVEEAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSI 853
+ +EE P L GVS+++L K + + A+ GL+L+FY+G IT+FLGHNGAGKTTT+SI
Sbjct: 886 ICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSI 945
Query: 854 LSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSA 913
L+GLFPP+ G+A+ILG D+RS M+ IR +LGVCPQ+NVLFDMLTV+EH+WFY RLKGLS
Sbjct: 946 LTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSE 1005
Query: 914 AVVGPEQDRLLQDVGLVS-KQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDP 972
V E +++ DVGL S K +T LSGGMQRKLSVA+AFVGGS+VVILDEPTAGVDP
Sbjct: 1006 KHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDP 1065
Query: 973 ASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSG 1032
SRRGIWELLLKYR+GRT+ILSTHH+DEA++LGDR+A+++ G+LCC GS LFL+ LG+G
Sbjct: 1066 YSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTG 1125
Query: 1033 YYLTLVKARLPLTTN------------EKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLA 1080
YYLTLVK + + + +K D+ + S D + S + +
Sbjct: 1126 YYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISN 1185
Query: 1081 LVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLE 1140
L++ V ARLVE++ HEL VLPY A +G+F LF E+D RL++L ++ YGIS+T+LE
Sbjct: 1186 LIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLE 1245
Query: 1141 EIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAG-SAPET 1199
EIFLKV EE D + DG+ G + + A N + ET
Sbjct: 1246 EIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRET 1305
Query: 1200 DQGSGPDAVG--RVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFS 1257
D SG D G +V+GW LT+QQ ALL KR L+ARRSR+G FAQIVLPA+FV +ALVFS
Sbjct: 1306 DLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFS 1365
Query: 1258 LIVPPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAG----------LE 1307
LIVPPFG YP+L L P MY Q +F S DAP D G LL AL ++ G +
Sbjct: 1366 LIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIP 1425
Query: 1308 EPPVQHSSHRFSAPEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPP 1367
+ P Q ++ VP + + +GNWT ++PSPACQCS +++LP CP AGG P
Sbjct: 1426 DTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLP 1485
Query: 1368 PPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLG-GRDPGL 1426
PPQ + +++Q+LTGRN+SD+LVKTY +++ + LK K WVNE RYGGFSLG L
Sbjct: 1486 PPQRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQAL 1545
Query: 1427 PSGQELGRSVEELWALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAF 1486
P QE+ +++++ L + DR L +L + LD ++++K+WFNNKGWH++ +F
Sbjct: 1546 PPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSF 1605
Query: 1487 VNRASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAM 1546
+N +NAILRA+L G + IT NHPLNLTK+QLSE ALM +SVDVLVSICV+FAM
Sbjct: 1606 LNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAM 1665
Query: 1547 SFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQ 1606
SFVPASF + LI+ERV++AKHLQ + G+ P +YWL NF+WDMCNY+VPA +V++IF+ FQ
Sbjct: 1666 SFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQ 1725
Query: 1607 QRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMAT 1666
Q++YV+ NLP L LLLLLYGWSITPLMYPASF F +PSTAYVVLT +NLFIGINGS+AT
Sbjct: 1726 QKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVAT 1785
Query: 1667 FVLELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLR 1726
FVLELF+D KL ++ ILK VFLIFPHFCLGRGLIDMV+NQAMADA ER G+ +F SPL
Sbjct: 1786 FVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLS 1845
Query: 1727 WEVVGKNLLAMVIQGPLFLLFTLLLQHRSQLLPQPRVRSLPLLGEEDEDVARERERVVQG 1786
W++VG+NL AM ++G +F L T+L+Q+R + P+P L L +EDEDV RER+R++ G
Sbjct: 1846 WDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDG 1905
Query: 1787 ATQGDVLVLRNLTKVYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLA 1846
Q D+L ++ LTK+YR +R PAVDR+C+GIPPGECFGLLGVNGAGK+STF+M+TGDT
Sbjct: 1906 GGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTV 1965
Query: 1847 SRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTA 1906
+RG+A L +S+ H +MGYCPQ DAI ELLTGREH+E A LRGVPE +V +
Sbjct: 1966 TRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVG 2025
Query: 1907 GSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWN 1966
+ +LGL Y ++ AG YSGGNKRKL+TA+AL+G P VVFLDEPTTGMDP ARRFLWN
Sbjct: 2026 EWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWN 2085
Query: 1967 SLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRV 2026
L+VV+EGRSV+LTSHSMEECEALC+R+AIMVNGRFRCLGS QHLK RF G+T+ +R+
Sbjct: 2086 CALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRI 2145
Query: 2027 PAARS--QPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVE 2084
+ +P F FPG+ L+E H L++QL P +LAR+F L+ +E
Sbjct: 2146 AGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQL-PSSLSSLARIFSILSQSKKRLHIE 2204
Query: 2085 DFSVSQTMLEEVFLYFSKDQGKDEDTEE 2112
D+SVSQT L++VF+ F+KDQ D+ ++
Sbjct: 2205 DYSVSQTTLDQVFVNFAKDQSDDDHLKD 2232
Score = 170 bits (430), Expect = 2e-41
Identities = 76/139 (54%), Positives = 102/139 (73%)
Query: 1 MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKP 60
MA W QL LLLWKN +RRRQ QLL+E+ WPLF+F IL++VR S+PP E HECHFPNK
Sbjct: 1 MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKA 60
Query: 61 LPSAGTVPWLQGLICNVNNTCFPQLTPGEEPGRLSNFNDSLVSRLLADARTVLGGASAHR 120
+PSAGT+PW+QG+ICN NN CF TPGE PG + NFN S+V+RL +DAR +L +
Sbjct: 61 MPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDT 120
Query: 121 TLAGLGKLIATLRAARSTA 139
++ + K++ TL+ + ++
Sbjct: 121 SMKDMRKVLRTLQQIKKSS 139
>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
sapiens]
Length = 2273
Score = 1743 bits (4514), Expect = 0.0
Identities = 946/2033 (46%), Positives = 1285/2033 (63%), Gaps = 113/2033 (5%)
Query: 159 LLTSLLRTESLGLALGQAQEPLHSLLEAAEDLAQELLALRSLVEL----RALLQR--PRG 212
+L +LL + S G+ L +L QE + S+ +L R L+Q P
Sbjct: 256 VLPTLLDSRSQGINL----RSWGGILSDMSPRIQEFIHRPSMQDLLWVTRPLMQNGGPET 311
Query: 213 TSGPLELLSEALCSVRGPSSTVGPSLNWYEASDLMELVGQEPESALP----DSSLSPACS 268
+ + +LS+ LC + S NWYE ++ +G + P D + C+
Sbjct: 312 FTKLMGILSDLLCGYPEGGGSRVLSFNWYEDNNYKAFLGIDSTRKDPIYSYDRRTTSFCN 371
Query: 269 ELIGALDSHPLSRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEELTLLRDVREVW 328
LI +L+S+PL+++ WR KPL++GK+L+ PD+P R+++ N TFEEL +R + + W
Sbjct: 372 ALIQSLESNPLTKIAWRAAKPLLMGKILYTPDSPAARRILKNANSTFEELEHVRKLVKAW 431
Query: 329 EMLGPRIFTFMNDSSNVAMLQRLL---QMQDEGRRQPRPGGRDHMEALRSFLDPGS---- 381
E +GP+I+ F ++S+ + M++ L ++D RQ G EA+ +FL G
Sbjct: 432 EEVGPQIWYFFDNSTQMNMIRDTLGNPTVKDFLNRQLGEEGIT-AEAILNFLYKGPRESQ 490
Query: 382 ----GGYSWQDAHADVGHLVGTLGRVTECLSLDKLEAAPSEAALVSRALQLLAEHRFWAG 437
+ W+D + + + ECL LDK E+ E L RAL LL E+ FWAG
Sbjct: 491 ADDMANFDWRDIFNITDRTLRLVNQYLECLVLDKFESYNDETQLTQRALSLLEENMFWAG 550
Query: 438 VVFLGPEDSSDPTEHPTPDLGPGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTDLR 497
VVF P +P P HV+ KIRMDIDVV +TNKI+DR+WD GP ADP+ D R
Sbjct: 551 VVF--------PDMYPWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFR 602
Query: 498 YVWGGFVYLQDLVERAAVRVLSGANPRAGLYLQQMPYPCYVDDVFLRVLSRSLPLFLTLA 557
Y+WGGF YLQD+VE+ R A G+YLQQMPYPC+VDD F+ +L+R P+F+ LA
Sbjct: 603 YIWGGFAYLQDMVEQGITRSQVQAEAPVGIYLQQMPYPCFVDDSFMIILNRCFPIFMVLA 662
Query: 558 WIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLG 617
WIYSV++TVK++V EKE RL++T++ G+S AV+W WFL +S LL + + G
Sbjct: 663 WIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHG 722
Query: 618 DILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAW 677
IL YS P ++FLFL AF+ AT+ FLLS FFS+A+LAAAC G+ YF+LYLP++LC AW
Sbjct: 723 RILHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCFAW 782
Query: 678 RDRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPT-ADVFSLAQVSGL 736
+DR+ A + A SLLSPVAFGFG E L EEQG G QW N+G PT D FS +
Sbjct: 783 QDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQM 842
Query: 737 LLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCG--------PRPPKSPAPCPT 788
+LLDAA+YGL WYL+ V PG YG P PW F + SYW G R + P
Sbjct: 843 MLLDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTE 902
Query: 789 PL-DPK-------VLVEEAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFL 840
DP+ E PG PGV V++L K F +PA+ L++ FY+ ITAFL
Sbjct: 903 ETEDPEHPEGIHDSFFEREHPGWVPGVCVKNLVKIFEPCGRPAVDRLNITFYENQITAFL 962
Query: 841 GHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDE 900
GHNGAGKTTTLSIL+GL PP+ G+ + G D+ +S+ A+R LG+CPQ+N+LF LTV E
Sbjct: 963 GHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTVAE 1022
Query: 901 HVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQV 960
H+ FY +LKG S E + +L+D GL K++ + + LSGGMQRKLSVAIAFVG ++V
Sbjct: 1023 HMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKV 1082
Query: 961 VILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCG 1020
VILDEPT+GVDP SRR IW+LLLKYR GRT+I+STHH+DEA+LLGDR+A++A GRL C G
Sbjct: 1083 VILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSG 1142
Query: 1021 SPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVG--TPQ- 1077
+PLFL+ G+G YLTLV+ + + K EG+ + + + + V TP+
Sbjct: 1143 TPLFLKNCFGTGLYLTLVRKMKNIQSQRKGS---EGTCSCSSKGFSTTCPAHVDDLTPEQ 1199
Query: 1078 --------LLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRL 1129
L+ +V H VP A+LVE + EL+ +LP ++A+LFREL+ LA+L L
Sbjct: 1200 VLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGL 1259
Query: 1130 TGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQ-------HLCTGI---AGLDVTLRLK 1179
+ +GISDT LEEIFLKV E+ + G+ + H C G AG +
Sbjct: 1260 SSFGISDTPLEEIFLKVTEDSDSGPLFAGGAQQKRENVNPRHPCLGPREKAG-------Q 1312
Query: 1180 MPPQETALENGEPAGSAPETDQGSGPDAVGRV--QGWALTRQQLQALLLKRFLLARRSRR 1237
P G PA PE P+ G G L Q +QALL+KRF RS +
Sbjct: 1313 TPQDSNVCSPGAPAAH-PEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHK 1371
Query: 1238 GLFAQIVLPALFVGLALVFSLIVPPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLL 1297
AQIVLPA FV LAL+ S+++PPFG YPAL L P +YG Q +FFS D PG L
Sbjct: 1372 DFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLA 1431
Query: 1298 EALLQEAG----------LEEPPVQHSSHRFSAPEVPAEVAKVLASGNWTPESPSPACQC 1347
+ LL + G L E P +S+ + P V + ++ WT +PSP+C+C
Sbjct: 1432 DVLLNKPGFGNRCLKEGWLPEYPCGNSTP-WKTPSVSPNITQLFQKQKWTQVNPSPSCRC 1490
Query: 1348 SRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLVRQGLKTKK 1407
S +LP+CP AGG PPPQ S E++Q+LT RN+SDFLVKTYP L+R LK+K
Sbjct: 1491 STREKLTMLPECPEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKF 1550
Query: 1408 WVNEVRYGGFSLGGRDPGLP-SGQELGRSVEELWALLSPLPGGALDRVLKNLTAWAHSLD 1466
WVNE RYGG S+GG+ P +P +G+ L + +L +++ G K + + L+
Sbjct: 1551 WVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLE 1610
Query: 1467 AQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLSE 1526
+D++K+WFNNKGWH++V+F+N A NAILRA LP + + IT ++ PLNLTKEQLSE
Sbjct: 1611 TEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSE 1670
Query: 1527 GALMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLW 1586
++ +SVD +V+ICV+F+MSFVPASF L LI+ERV ++KHLQ + G+SPT YW+ NFLW
Sbjct: 1671 ITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLW 1730
Query: 1587 DMCNYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPST 1646
D+ NY V A +VV IF+ FQ++AY +P NLPAL+ LLLLYGW++ P+MYPASF F VPST
Sbjct: 1731 DIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPST 1790
Query: 1647 AYVVLTCINLFIGINGSMATFVLELFSDQK-LQEVSRILKQVFLIFPHFCLGRGLIDMVR 1705
AYV L+C NLFIGIN S TF+LELF + + L + +L+++ ++FPHFCLGRGLID+
Sbjct: 1791 AYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLAL 1850
Query: 1706 NQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQHR---SQLLPQPR 1762
+QA+ D + R G+ +P W+++GKNL AMV++G ++ L TLL+Q SQ + +P
Sbjct: 1851 SQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAEPT 1910
Query: 1763 VRSLPLLGEEDEDVARERERVVQGATQGDVLVLRNLTKVYRGQRMPAVDRLCLGIPPGEC 1822
+ +ED+DVA ER+R++ G + D+L L LTK+Y G PAVDRLC+G+ PGEC
Sbjct: 1911 KEPIV---DEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGEC 1967
Query: 1823 FGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELL 1882
FGLLGVNGAGKT+TF+M+TGDT + G+A +AG S+ S H +MGYCPQ DAI ELL
Sbjct: 1968 FGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELL 2027
Query: 1883 TGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVG 1942
TGREHL L ARLRGVP ++ + A + LGL+ YAD AGTYSGGNKRKL+TA+AL+G
Sbjct: 2028 TGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIG 2087
Query: 1943 DPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGR 2002
P +V LDEPTTGMDP ARR LWN +++++REGR+V+LTSHSMEECEALC+RLAIMV G
Sbjct: 2088 CPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGA 2147
Query: 2003 FRCLGSPQHLKGRFAAGHTLTLRVPAARS------QPAAAFVAAEFPGAELREAHGGRLR 2056
FRC+G+ QHLK +F G+ +T+++ + + P F FPG+ RE H L+
Sbjct: 2148 FRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQ 2207
Query: 2057 FQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKDQGKDED 2109
FQ+ +LAR+F L H +E++SV+QT L++VF+ F+K Q + D
Sbjct: 2208 FQV---SSSSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQTESHD 2257
Score = 149 bits (375), Expect = 4e-35
Identities = 82/236 (34%), Positives = 133/236 (56%), Gaps = 13/236 (5%)
Query: 1 MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKP 60
M F Q+ LLLWKN+ R+RQ ++ +VEL+WPL LF +L+ +R+++P HHECHFPNK
Sbjct: 1 MGFVRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKA 60
Query: 61 LPSAGTVPWLQGLICNVNNTCFPQLTPGEEPGRLSNFNDSLVSRLLADARTVLGGASAHR 120
+PSAG +PWLQG+ CNVNN CF TPGE PG +SN+N+S+++R+ D + +L A +
Sbjct: 61 MPSAGMLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNSILARVYRDFQELLMNAPESQ 120
Query: 121 TLAGLGKLIATLRAARSTAQPQPTKQSPLEPPMLDVAE--------LLTSLLRTESLGLA 172
L + + L T + P + + + D+ + L+ ++ ++S+
Sbjct: 121 HLGRIWTELHILSQFMDTLRTHPERIAGRGIRIRDILKDEETLTLFLIKNIGLSDSVVYL 180
Query: 173 LGQAQEPLHSLLEAAEDLA-QELLALRSLVELRALLQRPRGTSGPLELLSEALCSV 227
L +Q DLA +++ +L+E + + RG + + ALCS+
Sbjct: 181 LINSQVRPEQFAHGVPDLALKDIACSEALLERFIIFSQRRGA----KTVRYALCSL 232
>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
[Homo sapiens]
Length = 2436
Score = 1258 bits (3255), Expect = 0.0
Identities = 793/2015 (39%), Positives = 1123/2015 (55%), Gaps = 235/2015 (11%)
Query: 294 KLLFAPDTPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPRIFTFMNDSSNVAMLQRLLQ 353
K+L+AP +++ + N TF + + +VW + I +F+ L+ L Q
Sbjct: 459 KILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRSFLEQGRLQQHLRWLQQ 518
Query: 354 MQDEGRRQPRPGGRDHME---ALR--SFLDPGSGGYSWQDAHADVGHLVGTLGRVTECLS 408
E R P E ALR +F P SG Q G + +++ +S
Sbjct: 519 YVAELRLHPEALNLSLDELPPALRQDNFSLP-SGMALLQQLDTIDNAACGWIQFMSK-VS 576
Query: 409 LDKLEAAPSEAALVSRALQLLAEHRF--WAGVVFLGPEDSSDPTEHPTPDLGPGHVRIKI 466
+D + P E ++V+ L + +A V+F +D S P HV KI
Sbjct: 577 VDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPP----------HVHYKI 626
Query: 467 RMDIDVVTRTNKIRDRFWDPGPAADPLTDLRYVWGGFVYLQDLVERAAVRVLSGANP-RA 525
R + +TN+IR +W PGP Y GFV++QD++ERA + G +
Sbjct: 627 RQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLY---GFVWIQDMMERAIIDTFVGHDVVEP 683
Query: 526 GLYLQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMG 585
G Y+Q PYPCY D FL V+ +PL + ++W+YSV +T++ +V EKE RL++ M+ MG
Sbjct: 684 GSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMG 743
Query: 586 LSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPGVVFLFLAAFAVATVTQSFL 645
L+ AV W+ WF++ +S L +LK G +L +SH +++LFLA +AVAT+ FL
Sbjct: 744 LNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFL 803
Query: 646 LSAFFSRANLAAACGGLAYFSLYLPYVLCVAWR-----DRLPAGGRVAASLLSPVAFGFG 700
+S +S+A LA+ACGG+ YF Y+PY+ VA R D++ A + ASL+S AFG G
Sbjct: 804 VSVLYSKAKLASACGGIIYFLSYVPYMY-VAIREEVAHDKITAFEKCIASLMSTTAFGLG 862
Query: 701 CESLALLEEQGEGAQWHNVGTRPT-ADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQY 759
+ AL E G G QWH P D F+L +L++DA +YG+ TWY+EAV PG Y
Sbjct: 863 SKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMY 922
Query: 760 GIPEPWNFPFRRSYWCGP-RPPKSPAPCPTPLDPKVLV--------------------EE 798
G+P PW FP ++SYW G R P P++ V EE
Sbjct: 923 GLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEE 982
Query: 799 APPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLF 858
P L V V L K + + AL LSL+ Y+ + +FLGHNGAGKTTT+SIL+GLF
Sbjct: 983 EPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLF 1042
Query: 859 PPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGP 918
PP+ GSA I GHD+R+ M IR +LG+CPQ+NVLFD LTV+EH+WFY RLK ++ +
Sbjct: 1043 PPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRR 1102
Query: 919 EQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGI 978
E D++++D+ L +K+ + LSGGM+RKLSVAIAFVGGS+ +ILDEPTAGVDP +RR I
Sbjct: 1103 EMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAI 1162
Query: 979 WELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLV 1038
W+L+LKY+ GRT++LSTHH+DEA+LLGDR+A+++ G+L CCGSPLFL+ G GY LTLV
Sbjct: 1163 WDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLV 1222
Query: 1039 KARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHE 1098
K P + + S R + S+ Q+ ++ V LV + E
Sbjct: 1223 KR--PAEPGGPQEPGLASSPPGRAPLSSCSE------LQVSQFIRKHVASCLLVSDTSTE 1274
Query: 1099 LVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEE------CAA 1152
L +LP A G+F LF+ L+ L L L+ +G+ DT+LEE+FLKV EE A
Sbjct: 1275 LSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEA 1334
Query: 1153 DT-----DMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSG--- 1204
D D+ G+ G G AG ++ ++ + +L++ GSA D+G+G
Sbjct: 1335 DVKESRKDVLPGAEGPASGEGHAG-NLARCSELTQSQASLQSASSVGSA-RGDEGAGYTD 1392
Query: 1205 --------------PDAVG--RVQGWALTR---------------QQLQALLLKRFLLAR 1233
PD V V+ AL+R +Q LL+KRF AR
Sbjct: 1393 VYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLKVRQFHGLLVKRFHCAR 1452
Query: 1234 RSRRGLFAQI------VLPALFVGLALVFSLIVPPFGHYPA------------------- 1268
R+ + LF+QI V A+ V L++ +PP P+
Sbjct: 1453 RNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEE 1512
Query: 1269 -----LRLSPTMYGAQ-VSFF------------SEDAPGDPG-------------RARLL 1297
LRLSP Q VS F A G G AR
Sbjct: 1513 RREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLSSGESRLLAARFF 1572
Query: 1298 EALLQEAGLEEPPVQHSSHRFSAP---EVPAEVAKVLASGNWT-PESPSPACQCSRPGAR 1353
+++ E+ + P+ + +P + PA + L + N + P + P S P
Sbjct: 1573 DSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTAGPEMWTSAPSLP 1632
Query: 1354 RLLPD--------------CPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLV 1399
RL+ + CP++ GG PP V +G+++ ++TG N+S++L+ T R
Sbjct: 1633 RLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVV-TGDILTDITGHNVSEYLLFTSDRFR 1691
Query: 1400 RQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEELWALLSPLPGGALDRVLKNLT 1459
RYG + G +L +P R
Sbjct: 1692 LH-----------RYGAITFGN--------------------VLKSIPASFGTRA----P 1716
Query: 1460 AWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLPPGPARHA-HSITTLNHPLN 1518
+ + + ++++NNKG+HSM ++N +NAILRA+LP A + IT NHP+N
Sbjct: 1717 PMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMN 1776
Query: 1519 LTKEQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTL 1578
T LS L+ + DV+++I ++ AMSFVPASF + L+ E+ T+AKHLQ + G +P +
Sbjct: 1777 KTSASLSLDYLLQGT-DVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPII 1835
Query: 1579 YWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPAS 1638
YWL N++WDM NYLVPA V+I F AY +P N PA+L L LLYGWSITP+MYPAS
Sbjct: 1836 YWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPAS 1895
Query: 1639 FFFSVPSTAYVVLTCINLFIGINGSMATFVLELFS-DQKLQEVSRILKQVFLIFPHFCLG 1697
F+F VPS+AYV L INLFIGI ++ATF+L+LF D+ L+ V+ LK FLIFP++ LG
Sbjct: 1896 FWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLG 1955
Query: 1698 RGLIDMVRNQAMADAFERLGD-RQFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQHRSQ 1756
GL++M N+ + + + ++G + +SP W++V + L+AM ++G + L T++ Q+
Sbjct: 1956 HGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVVGFLLTIMCQYNFL 2015
Query: 1757 LLPQPR-VRSLPLLGEEDEDVARERERVVQGATQGDVLVLRNLTKVYRGQ---RMPAVDR 1812
PQ V + P+ E+D DVA ER+RV++G D++ + NLTKVY+ + R+ AVDR
Sbjct: 2016 RRPQRMPVSTKPV--EDDVDVASERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDR 2073
Query: 1813 LCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYC 1872
LCLG+ PGECFGLLGVNGAGKTSTF+M+TGD + GEA + GHSV +E S+GYC
Sbjct: 2074 LCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSLGYC 2133
Query: 1873 PQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKR 1932
PQ DA+F+ LT REHL+L RLRG+ A+ L +L L+ YAD+PAGTYSGGNKR
Sbjct: 2134 PQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKR 2193
Query: 1933 KLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALC 1992
KL+TA+AL+G PA +FLDEPTTGMDP ARRFLWN +L +++ GRSV+LTSHSMEECEALC
Sbjct: 2194 KLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALC 2253
Query: 1993 SRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARS-QPAAAFVAAEFPGAELREAH 2051
+RLAIMVNGR RCLGS QHLK RF G+ +T+R +++S + F FP A L+E H
Sbjct: 2254 TRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNRNFPEAMLKERH 2313
Query: 2052 GGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKDQGKDEDTE 2111
++++QL +LA+VF ++ G+ED+SVSQT L+ VF+ F+K K D
Sbjct: 2314 HTKVQYQL-KSEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAK---KQSDNL 2369
Query: 2112 EQKEAGVGVDPAPGLQHPKRVSQFLDDPSTAETVL 2146
EQ+E +P LQ P L P +A T L
Sbjct: 2370 EQQE----TEPPSALQSPLGCLLSLLRPRSAPTEL 2400
Score = 59.7 bits (143), Expect = 3e-08
Identities = 34/74 (45%), Positives = 41/74 (55%), Gaps = 1/74 (1%)
Query: 1 MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHF-PNK 59
M F QL LLLWKN +RR P L E+ PL LFFIL+ +R P + E F
Sbjct: 1 MGFLHQLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAA 60
Query: 60 PLPSAGTVPWLQGL 73
PL SAG +P +Q L
Sbjct: 61 PLTSAGILPVMQSL 74
>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
[Homo sapiens]
Length = 2466
Score = 1258 bits (3255), Expect = 0.0
Identities = 793/2015 (39%), Positives = 1123/2015 (55%), Gaps = 235/2015 (11%)
Query: 294 KLLFAPDTPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPRIFTFMNDSSNVAMLQRLLQ 353
K+L+AP +++ + N TF + + +VW + I +F+ L+ L Q
Sbjct: 489 KILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRSFLEQGRLQQHLRWLQQ 548
Query: 354 MQDEGRRQPRPGGRDHME---ALR--SFLDPGSGGYSWQDAHADVGHLVGTLGRVTECLS 408
E R P E ALR +F P SG Q G + +++ +S
Sbjct: 549 YVAELRLHPEALNLSLDELPPALRQDNFSLP-SGMALLQQLDTIDNAACGWIQFMSK-VS 606
Query: 409 LDKLEAAPSEAALVSRALQLLAEHRF--WAGVVFLGPEDSSDPTEHPTPDLGPGHVRIKI 466
+D + P E ++V+ L + +A V+F +D S P HV KI
Sbjct: 607 VDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPP----------HVHYKI 656
Query: 467 RMDIDVVTRTNKIRDRFWDPGPAADPLTDLRYVWGGFVYLQDLVERAAVRVLSGANP-RA 525
R + +TN+IR +W PGP Y GFV++QD++ERA + G +
Sbjct: 657 RQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLY---GFVWIQDMMERAIIDTFVGHDVVEP 713
Query: 526 GLYLQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMG 585
G Y+Q PYPCY D FL V+ +PL + ++W+YSV +T++ +V EKE RL++ M+ MG
Sbjct: 714 GSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMG 773
Query: 586 LSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPGVVFLFLAAFAVATVTQSFL 645
L+ AV W+ WF++ +S L +LK G +L +SH +++LFLA +AVAT+ FL
Sbjct: 774 LNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFL 833
Query: 646 LSAFFSRANLAAACGGLAYFSLYLPYVLCVAWR-----DRLPAGGRVAASLLSPVAFGFG 700
+S +S+A LA+ACGG+ YF Y+PY+ VA R D++ A + ASL+S AFG G
Sbjct: 834 VSVLYSKAKLASACGGIIYFLSYVPYMY-VAIREEVAHDKITAFEKCIASLMSTTAFGLG 892
Query: 701 CESLALLEEQGEGAQWHNVGTRPT-ADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQY 759
+ AL E G G QWH P D F+L +L++DA +YG+ TWY+EAV PG Y
Sbjct: 893 SKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMY 952
Query: 760 GIPEPWNFPFRRSYWCGP-RPPKSPAPCPTPLDPKVLV--------------------EE 798
G+P PW FP ++SYW G R P P++ V EE
Sbjct: 953 GLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEE 1012
Query: 799 APPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLF 858
P L V V L K + + AL LSL+ Y+ + +FLGHNGAGKTTT+SIL+GLF
Sbjct: 1013 EPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLF 1072
Query: 859 PPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGP 918
PP+ GSA I GHD+R+ M IR +LG+CPQ+NVLFD LTV+EH+WFY RLK ++ +
Sbjct: 1073 PPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRR 1132
Query: 919 EQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGI 978
E D++++D+ L +K+ + LSGGM+RKLSVAIAFVGGS+ +ILDEPTAGVDP +RR I
Sbjct: 1133 EMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAI 1192
Query: 979 WELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLV 1038
W+L+LKY+ GRT++LSTHH+DEA+LLGDR+A+++ G+L CCGSPLFL+ G GY LTLV
Sbjct: 1193 WDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLV 1252
Query: 1039 KARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHE 1098
K P + + S R + S+ Q+ ++ V LV + E
Sbjct: 1253 KR--PAEPGGPQEPGLASSPPGRAPLSSCSE------LQVSQFIRKHVASCLLVSDTSTE 1304
Query: 1099 LVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEE------CAA 1152
L +LP A G+F LF+ L+ L L L+ +G+ DT+LEE+FLKV EE A
Sbjct: 1305 LSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEA 1364
Query: 1153 DT-----DMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSG--- 1204
D D+ G+ G G AG ++ ++ + +L++ GSA D+G+G
Sbjct: 1365 DVKESRKDVLPGAEGPASGEGHAG-NLARCSELTQSQASLQSASSVGSA-RGDEGAGYTD 1422
Query: 1205 --------------PDAVG--RVQGWALTR---------------QQLQALLLKRFLLAR 1233
PD V V+ AL+R +Q LL+KRF AR
Sbjct: 1423 VYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLKVRQFHGLLVKRFHCAR 1482
Query: 1234 RSRRGLFAQI------VLPALFVGLALVFSLIVPPFGHYPA------------------- 1268
R+ + LF+QI V A+ V L++ +PP P+
Sbjct: 1483 RNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEE 1542
Query: 1269 -----LRLSPTMYGAQ-VSFF------------SEDAPGDPG-------------RARLL 1297
LRLSP Q VS F A G G AR
Sbjct: 1543 RREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLSSGESRLLAARFF 1602
Query: 1298 EALLQEAGLEEPPVQHSSHRFSAP---EVPAEVAKVLASGNWT-PESPSPACQCSRPGAR 1353
+++ E+ + P+ + +P + PA + L + N + P + P S P
Sbjct: 1603 DSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTAGPEMWTSAPSLP 1662
Query: 1354 RLLPD--------------CPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLV 1399
RL+ + CP++ GG PP V +G+++ ++TG N+S++L+ T R
Sbjct: 1663 RLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVV-TGDILTDITGHNVSEYLLFTSDRFR 1721
Query: 1400 RQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEELWALLSPLPGGALDRVLKNLT 1459
RYG + G +L +P R
Sbjct: 1722 LH-----------RYGAITFGN--------------------VLKSIPASFGTRA----P 1746
Query: 1460 AWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLPPGPARHA-HSITTLNHPLN 1518
+ + + ++++NNKG+HSM ++N +NAILRA+LP A + IT NHP+N
Sbjct: 1747 PMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMN 1806
Query: 1519 LTKEQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTL 1578
T LS L+ + DV+++I ++ AMSFVPASF + L+ E+ T+AKHLQ + G +P +
Sbjct: 1807 KTSASLSLDYLLQGT-DVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPII 1865
Query: 1579 YWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPAS 1638
YWL N++WDM NYLVPA V+I F AY +P N PA+L L LLYGWSITP+MYPAS
Sbjct: 1866 YWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPAS 1925
Query: 1639 FFFSVPSTAYVVLTCINLFIGINGSMATFVLELFS-DQKLQEVSRILKQVFLIFPHFCLG 1697
F+F VPS+AYV L INLFIGI ++ATF+L+LF D+ L+ V+ LK FLIFP++ LG
Sbjct: 1926 FWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLG 1985
Query: 1698 RGLIDMVRNQAMADAFERLGD-RQFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQHRSQ 1756
GL++M N+ + + + ++G + +SP W++V + L+AM ++G + L T++ Q+
Sbjct: 1986 HGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVVGFLLTIMCQYNFL 2045
Query: 1757 LLPQPR-VRSLPLLGEEDEDVARERERVVQGATQGDVLVLRNLTKVYRGQ---RMPAVDR 1812
PQ V + P+ E+D DVA ER+RV++G D++ + NLTKVY+ + R+ AVDR
Sbjct: 2046 RRPQRMPVSTKPV--EDDVDVASERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDR 2103
Query: 1813 LCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYC 1872
LCLG+ PGECFGLLGVNGAGKTSTF+M+TGD + GEA + GHSV +E S+GYC
Sbjct: 2104 LCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSLGYC 2163
Query: 1873 PQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKR 1932
PQ DA+F+ LT REHL+L RLRG+ A+ L +L L+ YAD+PAGTYSGGNKR
Sbjct: 2164 PQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKR 2223
Query: 1933 KLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALC 1992
KL+TA+AL+G PA +FLDEPTTGMDP ARRFLWN +L +++ GRSV+LTSHSMEECEALC
Sbjct: 2224 KLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALC 2283
Query: 1993 SRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARS-QPAAAFVAAEFPGAELREAH 2051
+RLAIMVNGR RCLGS QHLK RF G+ +T+R +++S + F FP A L+E H
Sbjct: 2284 TRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNRNFPEAMLKERH 2343
Query: 2052 GGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKDQGKDEDTE 2111
++++QL +LA+VF ++ G+ED+SVSQT L+ VF+ F+K K D
Sbjct: 2344 HTKVQYQL-KSEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAK---KQSDNL 2399
Query: 2112 EQKEAGVGVDPAPGLQHPKRVSQFLDDPSTAETVL 2146
EQ+E +P LQ P L P +A T L
Sbjct: 2400 EQQE----TEPPSALQSPLGCLLSLLRPRSAPTEL 2430
>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
[Homo sapiens]
Length = 2277
Score = 1021 bits (2640), Expect = 0.0
Identities = 684/2015 (33%), Positives = 1061/2015 (52%), Gaps = 185/2015 (9%)
Query: 173 LGQAQEPLHSLLEAAEDLAQELLALRSLVELRALLQRPRGTS--GPLELLSEALCS---- 226
L Q H LL+ L Q L RS+ +A+ + R + G +S+ALCS
Sbjct: 359 LNQMASGTHPLLDKMRSLKQMHLP-RSVPLTQAMYRSNRMNTPQGSFSTISQALCSQGIT 417
Query: 227 -----VRGPSSTVGPSLNWYEASDLMELVGQEPES--ALPDSSLSPACSELIGALDSHPL 279
PSS P N + +L ++ S +P +S +P C L + + P
Sbjct: 418 TEYLTAMLPSSQ-RPKGNHTKDFLTYKLTKEQIASKYGIPINS-TPFCFSLYKDIINMPA 475
Query: 280 SRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPRIFTFM 339
++W LKP++LG++L+AP P T+ +M + N T +L LR+ + W P FM
Sbjct: 476 GPVIWAFLKPMLLGRILYAPYNPVTKAIMEKSNVTLRQLAELREKSQEWMDKSP---LFM 532
Query: 340 ND----SSNVAMLQRLLQMQDEGRRQPRPGGRDHMEALRSFLDPGSGGYSWQDAHADVGH 395
N + + MLQ L+ G D +E L+ + ++ + D+
Sbjct: 533 NSFHLLNQAIPMLQNTLRNPFVQVFVKFSVGLDAVELLKQIDELDILRLKLEN-NIDIID 591
Query: 396 LVGTLGRVT----ECLSLDKLEAAPSEAALVSRALQLLAEHRFWAGVVFLGPEDSSDPTE 451
+ TL +T C+ D+++AA + + A +L + + V+F P + S
Sbjct: 592 QLNTLSSLTVNISSCVLYDRIQAAKTIDEMEREAKRLYKSNELFGSVIFKLPSNRS---W 648
Query: 452 HPTPDLG----PGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTDLRYVWGGFVYLQ 507
H D G P ++ IRM + T +R + W PGP P + Y F+YLQ
Sbjct: 649 HRGYDSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPSHNQIY-GRAFIYLQ 707
Query: 508 DLVERAAVRVLSGANPRA-GLYLQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTV 566
D +ERA + + +G N + + +Q +PYPC++ D FL +S SLP+ L +AW+ + V
Sbjct: 708 DSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFV 767
Query: 567 KAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPG 626
K +V EK+ RL + M+ MG++ + W + +G L++ +L+++LK G+ILP ++
Sbjct: 768 KKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNILPKTNGF 827
Query: 627 VVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGR 686
++FL+ + ++ + + S+L+S FF+ N+AA G L Y + P+++ V + L +
Sbjct: 828 ILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENELSYVLK 887
Query: 687 VAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTAD-VFSLAQVSGLLLLDAALYG 745
V SLLSP AF + + +A EEQG G QW N+ T P D S + L+L D+ +Y
Sbjct: 888 VFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYF 947
Query: 746 LATWYLEAVCPGQYGIPEPWNFPFRRSYW-----CGP-RPPKSPAPCPTPL--------- 790
L WY+ V PG YG+ PW FP SYW C +P KS T +
Sbjct: 948 LIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSA 1007
Query: 791 DPKVL----VEEAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAG 846
P+ + +E P L+ GV++ + K + + A+ L+L+FY+GHIT+ LG NGAG
Sbjct: 1008 SPEYMFSSNIEPEPKDLTVGVALHGVTKIY--GSKVAVDNLNLNFYEGHITSLLGPNGAG 1065
Query: 847 KTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYG 906
KTTT+S+L+GLF S G+ F+ G D+++ + +R ++GVC Q++VLF LT EH+ YG
Sbjct: 1066 KTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYG 1125
Query: 907 RLK--GLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILD 964
+K + + E R L+D GL S + + LSGGM+RKLS++IA +GGS+VVILD
Sbjct: 1126 SIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILD 1185
Query: 965 EPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLF 1024
EP+ GVDP SRR IW+++ K + RT+ILSTHHLDEAE+L DR+A + G L CCGSP +
Sbjct: 1186 EPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFY 1245
Query: 1025 LRRHLGSGYYLTLVKARLP-LTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQ 1083
L+ G GY+LTL K + P L N DT + A++Q
Sbjct: 1246 LKEAFGDGYHLTLTKKKSPNLNANAVCDT-----------------------MAVTAMIQ 1282
Query: 1084 HWVPGARLVEELPHELVLVLP-YTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEI 1142
+P A L E++ ELV VLP ++ G++ +L R LD + +L + YGISDT++EE+
Sbjct: 1283 SHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEV 1342
Query: 1143 FLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQG 1202
FL + +E ++ M +HL G + P + S+ TD+
Sbjct: 1343 FLNLTKESQKNSAMSL----EHLTQKKIGNSNANGISTPDDLSV-------SSSNFTDRD 1391
Query: 1203 SGPDAVG-RVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVP 1261
G R+ G+ L +++ A+L+KRF RR+ +GL AQ++LP +FV A+ +
Sbjct: 1392 DKILTRGERLDGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTLRN 1451
Query: 1262 PFGHYPALRLSPTMYGA--QVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFS 1319
YP +++SP++YG Q +F+ A P L+ A+ G++ + S +
Sbjct: 1452 SSNSYPEIQISPSLYGTSEQTAFY---ANYHPSTEALVSAMWDFPGIDNMCLNTSDLQCL 1508
Query: 1320 APEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVV 1379
+ + K SG P + C CS + +CP PP + T S +V+
Sbjct: 1509 NKD---SLEKWNTSGE--PITNFGVCSCSEN-----VQECPKFNYSPPHRR--TYSSQVI 1556
Query: 1380 QNLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEEL 1439
NLTG+ + ++L+ T V++ RYGG+S G LP ++L +
Sbjct: 1557 YNLTGQRVENYLISTANEFVQK-----------RYGGWSFG-----LPLTKDLRFDIT-- 1598
Query: 1440 WALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHL 1499
G +R L K+W++ +G+HS+ A++N +N +LR ++
Sbjct: 1599 --------GVPANRTLA---------------KVWYDPEGYHSLPAYLNSLNNFLLRVNM 1635
Query: 1500 PPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIE 1559
A H I +HP ++Q E A ++S +D+LV++ ++ S ASF ++
Sbjct: 1636 SKYDAAR-HGIIMYSHPYPGVQDQ--EQATISSLIDILVALSILMGYSVTTASFVTYVVR 1692
Query: 1560 ERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPAL 1619
E T+AK LQ + G+ T YW+ NF++DM YLVP + I F+ A+ + NL A+
Sbjct: 1693 EHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLGAV 1752
Query: 1620 LLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQK--- 1676
LLLLL+G++ MY + F A++ C+NLF GIN ++ V+ S +K
Sbjct: 1753 SLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPND 1812
Query: 1677 --LQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNL 1734
L+ +S LK++FLIFP FC G GLI++ + Q++ D + G +G
Sbjct: 1813 PTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMF 1872
Query: 1735 LAMVIQGPLFLLFTLLLQHRSQLLPQPRVRSLPLLG-------EEDEDVARERERVVQGA 1787
+A+V QG +F F+L L L+ + R+ +EDEDV ER RV GA
Sbjct: 1873 VALVSQGTMF--FSLRLLINESLIKKLRLFFRKFNSSHVRETIDEDEDVRAERLRVESGA 1930
Query: 1788 TQGDVLVLRNLTKVYR--GQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTL 1845
+ D++ L LTK Y+ +++ AV+ + +GIP GECFGLLGVNGAGKT+ F+M+TGD +
Sbjct: 1931 AEFDLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDII 1990
Query: 1846 ASRGEAVLAGHSVAREPSAAHLSM-GYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQ 1904
S G ++ + + +H S+ GYCPQ DA+ +L+T EHL AR+ G+PE + +
Sbjct: 1991 PSSGNILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKE 2050
Query: 1905 TAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFL 1964
T L RL L + DR S G KRKL+TALAL+G P+++ LDEP++GMDP ++R L
Sbjct: 2051 TVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHL 2110
Query: 1965 WNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTL 2024
W + V+ SV+LTSHSMEECEALC+RLAIMVNG+F+C+GS QH+K RF G T+ +
Sbjct: 2111 WKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKV 2170
Query: 2025 RVPAAR--SQPAAAFVAAEFPGAELREAHGGRLRFQLP--PGGRCALARVFGELAVHGAE 2080
+ + + F+ FP L++ H L + +P GG +A +F L +
Sbjct: 2171 HLKNNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGG---VANIFDLLETNKTA 2227
Query: 2081 HGVEDFSVSQTMLEEVFLYFSKDQGKDE--DTEEQ 2113
+ +F VSQT LEEVF+ F+KDQ E DT Q
Sbjct: 2228 LNITNFLVSQTTLEEVFINFAKDQKSYETADTSSQ 2262
>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
[Homo sapiens]
Length = 2595
Score = 1021 bits (2640), Expect = 0.0
Identities = 685/2015 (33%), Positives = 1060/2015 (52%), Gaps = 185/2015 (9%)
Query: 173 LGQAQEPLHSLLEAAEDLAQELLALRSLVELRALLQRPRGTS--GPLELLSEALCS---- 226
L Q H LL+ L Q L RS+ +A+ + R + G +S+ALCS
Sbjct: 677 LNQMASGTHPLLDKMRSLKQMHLP-RSVPLTQAMYRSNRMNTPQGSFSTISQALCSQGIT 735
Query: 227 -----VRGPSSTVGPSLNWYEASDLMELVGQEPES--ALPDSSLSPACSELIGALDSHPL 279
PSS P N + +L ++ S +P +S +P C L + + P
Sbjct: 736 TEYLTAMLPSSQ-RPKGNHTKDFLTYKLTKEQIASKYGIPINS-TPFCFSLYKDIINMPA 793
Query: 280 SRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPRIFTFM 339
++W LKP++LG++L+AP P T+ +M + N T +L LR+ + W P FM
Sbjct: 794 GPVIWAFLKPMLLGRILYAPYNPVTKAIMEKSNVTLRQLAELREKSQEWMDKSP---LFM 850
Query: 340 ND----SSNVAMLQRLLQMQDEGRRQPRPGGRDHMEALRSFLDPGSGGYSWQDAHADVGH 395
N + + MLQ L+ G D +E L+ + ++ + D+
Sbjct: 851 NSFHLLNQAIPMLQNTLRNPFVQVFVKFSVGLDAVELLKQIDELDILRLKLEN-NIDIID 909
Query: 396 LVGTLGRVT----ECLSLDKLEAAPSEAALVSRALQLLAEHRFWAGVVFLGPEDSSDPTE 451
+ TL +T C+ D+++AA + + A +L + + V+F P + S
Sbjct: 910 QLNTLSSLTVNISSCVLYDRIQAAKTIDEMEREAKRLYKSNELFGSVIFKLPSNRS---W 966
Query: 452 HPTPDLG----PGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTDLRYVWGGFVYLQ 507
H D G P ++ IRM + T +R + W PGP P + Y F+YLQ
Sbjct: 967 HRGYDSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPSHNQIY-GRAFIYLQ 1025
Query: 508 DLVERAAVRVLSGANPRA-GLYLQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTV 566
D +ERA + + +G N + + +Q +PYPC++ D FL +S SLP+ L +AW+ + V
Sbjct: 1026 DSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFV 1085
Query: 567 KAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPG 626
K +V EK+ RL + M+ MG++ + W + +G L++ +L+++LK G+ILP ++
Sbjct: 1086 KKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNILPKTNGF 1145
Query: 627 VVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGR 686
++FL+ + ++ + + S+L+S FF+ N+AA G L Y + P+++ V + L +
Sbjct: 1146 ILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENELSYVLK 1205
Query: 687 VAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTAD-VFSLAQVSGLLLLDAALYG 745
V SLLSP AF + + +A EEQG G QW N+ T P D S + L+L D+ +Y
Sbjct: 1206 VFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYF 1265
Query: 746 LATWYLEAVCPGQYGIPEPWNFPFRRSYW-----CGP-RPPKSPAPCPTPL--------- 790
L WY+ V PG YG+ PW FP SYW C +P KS T +
Sbjct: 1266 LIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSA 1325
Query: 791 DPKVL----VEEAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAG 846
P+ + +E P L+ GV++ + K + + A+ L+L+FY+GHIT+ LG NGAG
Sbjct: 1326 SPEYMFSSNIEPEPKDLTVGVALHGVTKIY--GSKVAVDNLNLNFYEGHITSLLGPNGAG 1383
Query: 847 KTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYG 906
KTTT+S+L+GLF S G+ F+ G D+++ + +R ++GVC Q++VLF LT EH+ YG
Sbjct: 1384 KTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYG 1443
Query: 907 RLK--GLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILD 964
+K + + E R L+D GL S + + LSGGM+RKLS++IA +GGS+VVILD
Sbjct: 1444 SIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILD 1503
Query: 965 EPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLF 1024
EP+ GVDP SRR IW+++ K + RT+ILSTHHLDEAE+L DR+A + G L CCGSP +
Sbjct: 1504 EPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFY 1563
Query: 1025 LRRHLGSGYYLTLVKARLP-LTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQ 1083
L+ G GY+LTL K + P L N DT + A++Q
Sbjct: 1564 LKEAFGDGYHLTLTKKKSPNLNANAVCDT-----------------------MAVTAMIQ 1600
Query: 1084 HWVPGARLVEELPHELVLVLP-YTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEI 1142
+P A L E++ ELV VLP ++ G++ +L R LD + +L + YGISDT++EE+
Sbjct: 1601 SHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEV 1660
Query: 1143 FLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQG 1202
FL + +E ++ M +HL G + P + S+ TD+
Sbjct: 1661 FLNLTKESQKNSAMSL----EHLTQKKIGNSNANGISTPDDLSV-------SSSNFTDRD 1709
Query: 1203 SGPDAVG-RVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVP 1261
G R+ G+ L +++ A+L+KRF RR+ +GL AQ++LP +FV A+ +
Sbjct: 1710 DKILTRGERLDGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTLRN 1769
Query: 1262 PFGHYPALRLSPTMYGA--QVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFS 1319
YP +++SP++YG Q +F+ A P L+ A+ G++ + S +
Sbjct: 1770 SSNSYPEIQISPSLYGTSEQTAFY---ANYHPSTEALVSAMWDFPGIDNMCLNTSDLQCL 1826
Query: 1320 APEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVV 1379
+ + K SG P + C CS + +CP PP + T S +V+
Sbjct: 1827 NKD---SLEKWNTSGE--PITNFGVCSCSEN-----VQECPKFNYSPPHRR--TYSSQVI 1874
Query: 1380 QNLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEEL 1439
NLTG+ + ++L+ T V++ RYGG+S G LP ++L +
Sbjct: 1875 YNLTGQRVENYLISTANEFVQK-----------RYGGWSFG-----LPLTKDLRFDIT-- 1916
Query: 1440 WALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHL 1499
G +R L K+W++ +G+HS+ A++N +N +LR ++
Sbjct: 1917 --------GVPANRTLA---------------KVWYDPEGYHSLPAYLNSLNNFLLRVNM 1953
Query: 1500 PPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIE 1559
A H I +HP ++Q E A ++S +D+LV++ ++ S ASF ++
Sbjct: 1954 SKYDAAR-HGIIMYSHPYPGVQDQ--EQATISSLIDILVALSILMGYSVTTASFVTYVVR 2010
Query: 1560 ERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPAL 1619
E T+AK LQ + G+ T YW+ NF++DM YLVP + I F+ A+ + NL A+
Sbjct: 2011 EHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLGAV 2070
Query: 1620 LLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQK--- 1676
LLLLL+G++ MY + F A++ C+NLF GIN ++ V+ S +K
Sbjct: 2071 SLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPND 2130
Query: 1677 --LQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNL 1734
L+ +S LK++FLIFP FC G GLI++ + Q++ D + G +G
Sbjct: 2131 PTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMF 2190
Query: 1735 LAMVIQGPLFLLFTLLLQHRSQLLPQPRVRSLPLLG-------EEDEDVARERERVVQGA 1787
+A+V QG +F F+L L L+ + R+ +EDEDV ER RV GA
Sbjct: 2191 VALVSQGTMF--FSLRLLINESLIKKLRLFFRKFNSSHVRETIDEDEDVRAERLRVESGA 2248
Query: 1788 TQGDVLVLRNLTKVYR--GQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTL 1845
+ D++ L LTK Y+ +++ AV+ + +GIP GECFGLLGVNGAGKT+ F+M+TGD +
Sbjct: 2249 AEFDLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDII 2308
Query: 1846 ASRGEAVLAGHSVAREPSAAHLSM-GYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQ 1904
S G ++ + + +H S+ GYCPQ DA+ +L+T EHL AR+ G+PE + +
Sbjct: 2309 PSSGNILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKE 2368
Query: 1905 TAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFL 1964
T L RL L + DR S G KRKL+TALAL+G P+++ LDEP++GMDP ++R L
Sbjct: 2369 TVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHL 2428
Query: 1965 WNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLT- 2023
W + V+ SV+LTSHSMEECEALC+RLAIMVNG+F+C+GS QH+K RF G T+
Sbjct: 2429 WKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKV 2488
Query: 2024 -LRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLP--PGGRCALARVFGELAVHGAE 2080
L+ + F+ FP L++ H L + +P GG +A +F L +
Sbjct: 2489 HLKNNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGG---VANIFDLLETNKTA 2545
Query: 2081 HGVEDFSVSQTMLEEVFLYFSKDQGKDE--DTEEQ 2113
+ +F VSQT LEEVF+ F+KDQ E DT Q
Sbjct: 2546 LNITNFLVSQTTLEEVFINFAKDQKSYETADTSSQ 2580
Score = 71.6 bits (174), Expect = 8e-12
Identities = 31/76 (40%), Positives = 47/76 (61%)
Query: 6 QLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSAG 65
QL +L+WKN++ +RQP+ LV +LWP+ +F IL R PP C+ + LPS G
Sbjct: 7 QLQILVWKNWLGVKRQPLWTLVLILWPVIIFIILAITRTKFPPTAKPTCYLAPRNLPSTG 66
Query: 66 TVPWLQGLICNVNNTC 81
P+LQ L+C+ ++ C
Sbjct: 67 FFPFLQTLLCDTDSKC 82
>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
[Homo sapiens]
Length = 5058
Score = 980 bits (2533), Expect = 0.0
Identities = 671/1995 (33%), Positives = 997/1995 (49%), Gaps = 189/1995 (9%)
Query: 159 LLTSLLR-TESLGLALGQAQEPLHSLLEAAEDLAQELLALRSLVELRALLQRPRGTS--- 214
LL SLL SL L +AQ L E ++ AL ++ + + Q + S
Sbjct: 3182 LLNSLLDIVSSLSALLAKAQHVFEYLPEFLHTF--KITALLETLDFQQVSQNVQARSSAF 3239
Query: 215 GPLELLSEALCSVRGPSSTVGPSLNWYEASDLMELVGQEPESALPDSSLSPACSELIGAL 274
G + + + +C + +S + S + + EL+ + E +P C +L +
Sbjct: 3240 GSFQFVMKMVC--KDQASFLSDSNMFINLPRVKELLEDDKEKFNIPEDSTPFCLKLYQEI 3297
Query: 275 DSHPLSRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPR 334
P L+W LKP++ GK+L+ P+TP K++ + N TF + L+ + E +
Sbjct: 3298 LQLPNGALVWTFLKPILHGKILYTPNTPEINKVIQKANYTFYIVDKLKTLSETLLEMSS- 3356
Query: 335 IFTFMNDSSNVAMLQRLLQMQDEGRRQPRPGGRDHMEALRSFLDPGSGGYSWQDAHADVG 394
+F LQ L+ + D ++ L L G HA G
Sbjct: 3357 LFQRSGSGQMFNQLQEALRNKFVRNFVENQLHID-VDKLTEKLQTYGGLLDEMFNHAGAG 3415
Query: 395 H---LVGTLGRVTECLSLDKLEAAPSEAALVSRALQLLAEHRFWAGVVFLGPEDSSDPTE 451
L L ++ C++L++ +A S L ++A +LL ++ F A ++F D
Sbjct: 3416 RFRFLGSILVNLSSCVALNRFQALQSVDILETKAHELLQQNSFLASIIF--SNSLFDKNF 3473
Query: 452 HPTPDLGPGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTDLRYVWGGFVYLQDLVE 511
P HV IR ++ RT+ +++ W P P +Y + F LQD++E
Sbjct: 3474 RSESVKLPPHVSYTIRTNVLYSVRTDVVKNPSWKFHPQNLPADGFKYNYV-FAPLQDMIE 3532
Query: 512 RAAVRVLSGANP-RAGLYLQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVV 570
RA + V +G Q PYPC+ D+FL + PL + L W+ SV V+ +V
Sbjct: 3533 RAIILVQTGQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVSVASMVRKLV 3592
Query: 571 REKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPGVVFL 630
E+E ++ + MR MG+ + +L WFL + +S+A L +VLK I +S+ +VFL
Sbjct: 3593 YEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKTSGIFAHSNTFIVFL 3652
Query: 631 FLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGRVAAS 690
FL F ++ V S+LLSAFFS+AN AA C L Y +LPY++ + ++L +
Sbjct: 3653 FLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLLVLHNQLSFVNQTFLC 3712
Query: 691 LLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGLLLLDAALYGLATWY 750
LLS AFG G + LE Q G QW+N+ + V ++L D++LY L WY
Sbjct: 3713 LLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMTFGWVCWMILFDSSLYFLCGWY 3772
Query: 751 LEAVCPGQYGIPEPWNFPFRRSYW--CGPRPPKSPAPCPTPL-------DPKVLV----E 797
L + PG +G+ +PW FPF SYW G K + L D K E
Sbjct: 3773 LSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGSSLQNRE 3832
Query: 798 EAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGL 857
G +PGV++ S+ K + G + ++ LSL FY+ ITA LG NGAGKTT +S+L+GL
Sbjct: 3833 GELEGSAPGVTLVSVTKEYEGH-KAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGL 3891
Query: 858 FPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKG--LSAAV 915
PP+ G+ I G ++++ ++ +R LGVCPQ ++L D LTV EH+ + +K +
Sbjct: 3892 HPPTSGTIIINGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKE 3951
Query: 916 VGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASR 975
+ + ++ LQDV L Q QTR LSGG++RKLS+ IAF+G S+ V+LDEPT+GVDP SR
Sbjct: 3952 LHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSR 4011
Query: 976 RGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYL 1035
+W++LLKYREGRT+I +THHLDEAE L DRVAV+ GRL CCG P L+ G G L
Sbjct: 4012 HSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRL 4071
Query: 1036 TLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEEL 1095
TL + L ++ D + +L++ ++P A L +
Sbjct: 4072 TLTRQPSVLEAHDLKDMAC-----------------------VTSLIKIYIPQAFLKDSS 4108
Query: 1096 PHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEECAADTD 1155
EL +P LF+ LD L +L LTGYGISDT+LEE+FL +
Sbjct: 4109 GSELTYTIP-KDTDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFLML--------- 4158
Query: 1156 MEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSGPDAVGRVQGWA 1215
++D + H+ G E+ L+N P G A VQG
Sbjct: 4159 LQDSNKKSHIALGT--------------ESELQNHRPTGHLSGYCGSLARPAT--VQGVQ 4202
Query: 1216 LTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPALRLSPTM 1275
L R Q+ A+L +R R+ + A ++LP LFV LA+ ++ P YP LRL+P
Sbjct: 4203 LLRAQVAAILARRLRRTLRAGKSTLADLLLPVLFVALAMGLFMVRPLATEYPPLRLTPGH 4262
Query: 1276 YGAQVSFFSEDAPGDPGRARLLEALLQEAGLE----EPPVQHSS----HRFSAPEVPAEV 1327
Y ++F + R+L ++ L P ++SS FS PE
Sbjct: 4263 YQRAETYFFSSGGDNLDLTRVLLRKFRDQDLPCADLNPRQKNSSCWRTDPFSHPEF---- 4318
Query: 1328 AKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNL 1387
+C C + CP + P G + NL+G N+
Sbjct: 4319 --------------QDSCGCLK---------CPNRSASAP--YLTNHLGHTLLNLSGFNM 4353
Query: 1388 SDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEELWALLSPLP 1447
++L+ + R GG+S G + P
Sbjct: 4354 EEYLLAPSEK--------------PRLGGWSFGLKIPSEA-------------------- 4379
Query: 1448 GGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLPPGPARHA 1507
GGA + K T K+W+N KG+HS+ +++N +N IL HLPP
Sbjct: 4380 GGANGNISKPPTL----------AKVWYNQKGFHSLPSYLNHLNNLILWQHLPPTVDWRQ 4429
Query: 1508 HSITTLNHPLN---LTKEQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTR 1564
+ IT +HP L K+++ E V++C+V S + AS ++ +RV
Sbjct: 4430 YGITLYSHPYGGALLNKDKILESIRQCG-----VALCIVLGFSILSASIGSSVVRDRVIG 4484
Query: 1565 AKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLL 1624
AK LQ + GL +YW NFL+DM YLV C+ V + +AFQ A+ NL A LLL
Sbjct: 4485 AKRLQHISGLGYRMYWFTNFLYDMLFYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLS 4544
Query: 1625 LYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFS----DQKLQEV 1680
L+G++ P MY S FS A++ +N G+ + T + L + + LQ +
Sbjct: 4545 LFGYATLPWMYLMSRIFSSSDVAFISYVSLNFIFGLCTMLITIMPRLLAIISKAKNLQNI 4604
Query: 1681 SRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQ 1740
+LK VF IFP FCLG+GL+++ NQ D G + SP +G + + Q
Sbjct: 4605 YDVLKWVFTIFPQFCLGQGLVELCYNQIKYDLTHNFGIDSYVSPFEMNFLGWIFVQLASQ 4664
Query: 1741 GPLFLLFTLLLQHRSQLLPQPRVRSL---PLLGEEDEDVARERERVVQGATQGDVLVLRN 1797
G + LL +LL LL PR S + +D DV +E +RV +G T GD+LVL N
Sbjct: 4665 GTVLLLLRVLLHW--DLLRWPRGHSTLQGTVKSSKDTDVEKEEKRVFEGRTNGDILVLYN 4722
Query: 1798 LTKVYRG--QRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLA- 1854
L+K YR Q + AV + LGIP GECFGLLGVNGAGK++TF+M+ G+ + G A++
Sbjct: 4723 LSKHYRRFFQNIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRT 4782
Query: 1855 --GHSV-AREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLA 1911
G +V A + +GYCPQ DA+ ELLTG EHL LRG+P + + AG +
Sbjct: 4783 PMGDAVDLSSAGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIR 4842
Query: 1912 RLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAV 1971
RL L +AD+P TYSGG KRKL+TALALVG P ++ LDEP++GMDP ++R+LW +++
Sbjct: 4843 RLHLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKE 4902
Query: 1972 VREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARS 2031
VREG + +LTSHSMEECEALC+RLAIMVNG F+CLGSPQH+K RF G+T+ + + +
Sbjct: 4903 VREGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEAN 4962
Query: 2032 Q--PAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVS 2089
Q + + FPG + + H L + +P C LA +F + + ++ +S++
Sbjct: 4963 QHCTVSDHLKLYFPGIQFKGQHLNLLEYHVPKRWGC-LADLFKVIENNKTFLNIKHYSIN 5021
Query: 2090 QTMLEEVFLYFSKDQ 2104
QT LE+VF+ F+ +Q
Sbjct: 5022 QTTLEQVFINFASEQ 5036
Score = 179 bits (455), Expect = 2e-44
Identities = 163/622 (26%), Positives = 278/622 (44%), Gaps = 64/622 (10%)
Query: 1529 LMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDM 1588
L ++V + ++ AS L+ E+ + + M G+ P +++L FL +M
Sbjct: 3563 LFLNNVGFFFPLIMMLTWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENM 3622
Query: 1589 CNYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAY 1648
+ + + ++ + A +N + L LL +G S+ L Y S FFS +TA
Sbjct: 3623 AVLTISSATLAIVL---KTSGIFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAA 3679
Query: 1649 VVLTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFL-IFPHFCLGRGL--IDMVR 1705
+ + + + S +++ L +L V+ Q FL + G+G+ I +
Sbjct: 3680 LCTSLVYMI-----SFLPYIVLLVLHNQLSFVN----QTFLCLLSTTAFGQGVFFITFLE 3730
Query: 1706 NQAMADAFERLGDRQFQSPLR-----WEVVGKNLLAMV--------------IQGPLFLL 1746
Q + + Q + W ++ + L + ++ P +
Sbjct: 3731 GQETGIQWNNMYQALEQGGMTFGWVCWMILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFP 3790
Query: 1747 FT--------LLLQHRSQLLPQPRVRSLPLLGEEDEDVA---RERERVVQGATQGDVLVL 1795
FT L++ R L SL E ++ + RE ++G+ G LV
Sbjct: 3791 FTASYWKSVGFLVEKRQYFLSS----SLFFFNENFDNKGSSLQNREGELEGSAPGVTLV- 3845
Query: 1796 RNLTKVYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAG 1855
++TK Y G + D L L + LLG NGAGKT+ M+TG + G ++ G
Sbjct: 3846 -SVTKEYEGHKAVVQD-LSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIING 3903
Query: 1856 HSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGV--PEAQVAQTAGSGLARL 1913
++ + S + +G CPQ D + + LT REHL L A ++ + ++ Q L +
Sbjct: 3904 KNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDV 3963
Query: 1914 GLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVR 1973
L+ + + SGG KRKL+ +A +G V LDEPT+G+DP +R LW+ LL R
Sbjct: 3964 DLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLK-YR 4022
Query: 1974 EGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTL-RVPAARSQ 2032
EGR+++ T+H ++E EAL R+A++ +GR RC G P LK + G LTL R P+
Sbjct: 4023 EGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQPSVLEA 4082
Query: 2033 P-------AAAFVAAEFPGAELREAHGGRLRFQLPPG-GRCALARVFGELAVHGAEHGVE 2084
+ + P A L+++ G L + +P + L +F L + + +
Sbjct: 4083 HDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQLHLT 4142
Query: 2085 DFSVSQTMLEEVFLYFSKDQGK 2106
+ +S T LEEVFL +D K
Sbjct: 4143 GYGISDTTLEEVFLMLLQDSNK 4164
Score = 75.1 bits (183), Expect = 7e-13
Identities = 38/94 (40%), Positives = 48/94 (51%), Gaps = 2/94 (2%)
Query: 6 QLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSAG 65
Q LLWKN++ R R PV L E WP LF IL +R PP C+ + LPS G
Sbjct: 7 QFKALLWKNWLCRLRNPVLFLAEFFWPCILFVILTVLRFQEPPRYRDICYLQPRDLPSCG 66
Query: 66 TVPWLQGLICNVNNTC--FPQLTPGEEPGRLSNF 97
+P++Q L+CN + C F E RLS F
Sbjct: 67 VIPFVQSLLCNTGSRCRNFSYEGSMEHHFRLSRF 100
>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
sapiens]
Length = 1704
Score = 495 bits (1275), Expect = e-139
Identities = 313/866 (36%), Positives = 460/866 (53%), Gaps = 94/866 (10%)
Query: 476 TNKIRDRFWDPGPAADPLTD---LRYVWGGFVYLQDLVERAAVRVLSGANPRA-----GL 527
T + F +PGP D Y+ GF+ +Q V+RA + + A R +
Sbjct: 181 TTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTV 240
Query: 528 YLQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLS 587
+++ PYP ++ D FL + LPL L L++ Y+ +AVV+EKE RL++ MR MGLS
Sbjct: 241 TIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLS 300
Query: 588 RAVLWLGWFLSCLGPFLLSAALLVLVLKLG-----DILPYSHPGVVFLFLAAFAVATVTQ 642
+ W WFL L++A+ + L+ + +L S P +V FL FA++T++
Sbjct: 301 SWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISF 360
Query: 643 SFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGRVAASLLSPVAFGFGCE 702
SF++S FFS+AN+AAA GG YF Y+PY + + ++ + LLS VA G +
Sbjct: 361 SFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQ 420
Query: 703 SLALLEEQGEGAQWHNVGTRPTADV-FSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGI 761
+ E +G G QW ++ + D F QV G+LLLD+ LYGL TWY+EAV PGQ+G+
Sbjct: 421 LIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGV 480
Query: 762 PEPWNFPFRRSYWCGPRPPKSPAPCPTPLDPKVLV-----EEAPPGLSPGVSVRSLEK-- 814
P+PW F SYWCG +P DP+ + E P L G+ ++ L K
Sbjct: 481 PQPWYFFIMPSYWCG-KPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVF 539
Query: 815 RFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRS 874
R + A+R L+L+ Y+G IT LGHNGAGKTTTLS+L+GLFPP+ G A+I G+++
Sbjct: 540 RVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQ 599
Query: 875 SMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQS 934
M IR LG+CPQ+++LFD LTV EH++FY +LKGLS E ++L +GL K +
Sbjct: 600 DMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWN 659
Query: 935 VQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILS 994
++R LSGGM+RKLS+ IA + GS+V+ILDEPT+G+D SRR IW+LL + + RT++L+
Sbjct: 660 SRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLT 719
Query: 995 THHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDM 1054
TH +DEA+LLGDR+A++A G L CCGS LFL++ G+GY++TLVK
Sbjct: 720 THFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKE-------------- 765
Query: 1055 EGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFA 1114
+ LV H VP A L EL +LP H F
Sbjct: 766 ----------------PHCNPEDISQLVHHHVPNATLESSAGAELSFILPRESTH--RFE 807
Query: 1115 TLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEECAADTDME----------------D 1158
LF +L+ + EL + +G S T++EE+FL+V + + D++ D
Sbjct: 808 GLFAKLEKKQKELGIASFGASITTMEEVFLRVGKLVDSSMDIQAIQLPALQYQHERRASD 867
Query: 1159 GSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSGPDAVGRVQGWALTR 1218
+ +LC A++ + G+ E ++ AV G AL
Sbjct: 868 WAVDSNLC------------------GAMDPSDGIGALIEEER----TAVKLNTGLALHC 905
Query: 1219 QQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPALRLSPTMYGA 1278
QQ A+ LK+ + R + + AQ+++P V LAL+ P LRL+ YG
Sbjct: 906 QQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTLGEYGR 965
Query: 1279 QVSFFSEDAPGDPGRARLLEALLQEA 1304
V FS PG + L L++A
Sbjct: 966 TVVPFS--VPGTSQLGQQLSEHLKDA 989
Score = 452 bits (1164), Expect = e-126
Identities = 265/666 (39%), Positives = 398/666 (59%), Gaps = 53/666 (7%)
Query: 1475 FNNKGWHSMVAFVNRASNAILRAHLPPGPARHAHSITTLNHP-----LNLTKEQLSEGAL 1529
FNN+ +HS + N + + P HA SI N P L K+Q +EG
Sbjct: 1042 FNNQAYHSPATALAVVDNLLFKLLCGP----HA-SIVVSNFPQPRSALQAAKDQFNEGR- 1095
Query: 1530 MASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMC 1589
D+ +++ +FAM+F+ ++F+++ + ER +AKH+Q + G+ +WL LWD+
Sbjct: 1096 --KGFDIALNL--LFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLI 1151
Query: 1590 NYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYV 1649
++L+P+ +++++F AF RA+ ++ LLLLLLYGW+I PLMY +FFF +TAY
Sbjct: 1152 SFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYT 1211
Query: 1650 VLTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVRN--- 1706
LT N+ GI + ++ + + KL+E+S+ L VFL+ P+ CLG + N
Sbjct: 1212 RLTIFNILSGIATFLMVTIMRIPA-VKLEELSKTLDHVFLVLPNHCLGMAVSSFYENYET 1270
Query: 1707 -------QAMADAFERLGDRQFQSPLRWEV--VGKNLLAMVIQGP-----LFLLFTLLLQ 1752
+ A ++ + ++ W VG+ + +M G LFL+ T LLQ
Sbjct: 1271 RRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQ 1330
Query: 1753 HRSQLLPQPRVRS--------LPLLGEEDEDVARERERVVQGATQGDV---LVLRNLTKV 1801
+L R R +P+L ED+DVA ER R++ + + L+++ L+KV
Sbjct: 1331 RLRGILCALRRRRTLTELYTRMPVL-PEDQDVADERTRILAPSPDSLLHTPLIIKELSKV 1389
Query: 1802 YRGQRMP--AVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVA 1859
Y QR+P AVDRL L + GECFGLLG NGAGKT+TF+M+TG+ + G+A + GH ++
Sbjct: 1390 YE-QRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRIS 1448
Query: 1860 REPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYA 1919
+ +GYCPQ DA+ + +TGRE L + ARLRG+PE + + L L L +A
Sbjct: 1449 SDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHA 1508
Query: 1920 DRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVM 1979
++ TYSGGNKRKL+T +AL+G+PAV+FLDEP+TGMDP ARR LW+++ G++++
Sbjct: 1509 NKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAII 1568
Query: 1980 LTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPA----A 2035
+TSHSMEECEALC+RLAIMV G+F+CLGSPQHLK +F +G++L +V + Q A
Sbjct: 1569 ITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFK 1628
Query: 2036 AFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEE 2095
AFV FPG+ L + H G + + L PG + A+VFG L ++GV+D+SVSQ LE+
Sbjct: 1629 AFVDLTFPGSVLEDEHQGMVHYHL-PGRDLSWAKVFGILEKAKEKYGVDDYSVSQISLEQ 1687
Query: 2096 VFLYFS 2101
VFL F+
Sbjct: 1688 VFLSFA 1693
Score = 194 bits (492), Expect = 1e-48
Identities = 177/636 (27%), Positives = 286/636 (44%), Gaps = 52/636 (8%)
Query: 1534 VDVLVSICVVFAMSFVPASFTLV--LIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNY 1591
V + + ++ +SF + T+ +++E+ R K M GLS L+W FL
Sbjct: 257 VAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFL 316
Query: 1592 LVPACIVVLIF-LAFQQRAYVAPANLPALLLLLLL-YGWSITPLMYPASFFFSVPSTAYV 1649
L+ A + L+F + + V + P+L+L LL + S + S FFS + A
Sbjct: 317 LIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAA 376
Query: 1650 VLTCINLFIGINGSMATFVLELFSDQKLQ--EVSRILKQVFLIFPHFCLGRGLIDMVRNQ 1707
+ F T++ F + +S+ L L +G LI +
Sbjct: 377 FGGFLYFF--------TYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAK 428
Query: 1708 AMADAFERLGDRQFQSPLR-------WEVVGKNLLAMVIQGPLFLLFTLLLQHRSQLLPQ 1760
M + R SP+ +V+G LL V+ G + + + + PQ
Sbjct: 429 GMGIQW-----RDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGV-PQ 482
Query: 1761 P------------RVRSLPLLGEEDEDVARERERVVQGATQGDVLV---LRNLTKVYR-- 1803
P + R++ EED D + A D++ +++L+KV+R
Sbjct: 483 PWYFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVG 542
Query: 1804 GQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPS 1863
+ AV L L + G+ LLG NGAGKT+T M+TG + G A ++G+ ++++
Sbjct: 543 NKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMV 602
Query: 1864 AAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPA 1923
S+G CPQ D +F+ LT EHL A+L+G+ + + L +GL + +
Sbjct: 603 QIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRS 662
Query: 1924 GTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSH 1983
SGG +RKL+ +AL+ V+ LDEPT+GMD +RR +W+ LL + R+++LT+H
Sbjct: 663 RFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWD-LLQRQKSDRTIVLTTH 721
Query: 1984 SMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTL-RVPAARSQPAAAFVAAEF 2042
M+E + L R+AIM G +C GS LK ++ AG+ +TL + P + + V
Sbjct: 722 FMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHV 781
Query: 2043 PGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSK 2102
P A L + G L F LP +F +L E G+ F S T +EEVFL K
Sbjct: 782 PNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGK 841
Query: 2103 DQGKDEDTEEQKEAGVGVDPAPGLQHPKRVSQFLDD 2138
D + + PA QH +R S + D
Sbjct: 842 LVDSSMDIQAIQL------PALQYQHERRASDWAVD 871
Score = 167 bits (423), Expect = 1e-40
Identities = 108/326 (33%), Positives = 165/326 (50%), Gaps = 31/326 (9%)
Query: 820 PQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAI 879
P A+ LSL +G LG NGAGKTTT +L+G + G AF+ GH + S + +
Sbjct: 1395 PLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKV 1454
Query: 880 RPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRH 939
R +G CPQ++ L D +T E + Y RL+G+ +G + L+ + L + R
Sbjct: 1455 RQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRT 1514
Query: 940 LSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYRE-GRTLILSTHHL 998
SGG +RKLS IA +G V+ LDEP+ G+DP +RR +W+ + + RE G+ +I+++H +
Sbjct: 1515 YSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSM 1574
Query: 999 DEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSV 1058
+E E L R+A++ G+ C GSP L+ GSGY L +A EG
Sbjct: 1575 EECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL-------------RAKVQSEGQQ 1621
Query: 1059 DTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFR 1118
+ +E K A V PG+ L +E + LP D S+A +F
Sbjct: 1622 EALEEFK--------------AFVDLTFPGSVLEDEHQGMVHYHLP---GRDLSWAKVFG 1664
Query: 1119 ELDTRLAELRLTGYGISDTSLEEIFL 1144
L+ + + Y +S SLE++FL
Sbjct: 1665 ILEKAKEKYGVDDYSVSQISLEQVFL 1690
Score = 36.2 bits (82), Expect = 0.36
Identities = 18/43 (41%), Positives = 27/43 (62%)
Query: 1 MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVR 43
MA QL LLLWKN+ ++R+ + ++EL PL IL+ +R
Sbjct: 1 MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLR 43
Score = 35.0 bits (79), Expect = 0.79
Identities = 30/111 (27%), Positives = 52/111 (46%), Gaps = 5/111 (4%)
Query: 549 SLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAA 608
+L L +A++ S T ++ AV E+ + + G+ A WL L L FL+ +
Sbjct: 1101 ALNLLFAMAFLAS-TFSILAV-SERAVQAKHVQFVSGVHVASFWLSALLWDLISFLIPSL 1158
Query: 609 LLVLVLKLGDILPYS---HPGVVFLFLAAFAVATVTQSFLLSAFFSRANLA 656
LL++V K D+ ++ H L L + A + +L++ FF A A
Sbjct: 1159 LLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATA 1209
>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
sapiens]
Length = 1624
Score = 280 bits (717), Expect = 8e-75
Identities = 228/804 (28%), Positives = 366/804 (45%), Gaps = 108/804 (13%)
Query: 502 GFVYLQDLVERAAVRVLSGANPR------AGLYLQQMPYPCY---VDDVFLRVLSRSLPL 552
GFV Q + A + + + + G++++ +P+ D F+ S
Sbjct: 177 GFVAFQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFST 236
Query: 553 FLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVL 612
F IY V++ V ++ + M MGL + WL W L G L+ A L+ L
Sbjct: 237 F-----IYYVSVNVT----QERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMAL 287
Query: 613 VLKLGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYV 672
++K I+ + +VF + ++ +T +FL+S + L GL F L + +
Sbjct: 288 IVKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLT----GLVVFLLIVFWG 343
Query: 673 LC--VAWRDRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTADVFSL 730
+ A RLPA LLSP AF G L L+ + P + +L
Sbjct: 344 ILGFPALYTRLPAFLEWTLCLLSPFAFTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATL 403
Query: 731 AQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYW----------CGPRPP 780
+L+ D LY + T Y + + P +YG F + +W
Sbjct: 404 F----MLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETD 459
Query: 781 KSPAP--CPTPLDPKVLVEEAPPGLSPGVSVRSLEKRFPGSPQ--PALRGLSLDFYQGHI 836
P P C P+ P+ +EA + +++L+K + G + AL+G+ D Y+G I
Sbjct: 460 SDPTPNDCFEPVSPEFCGKEA-------IRIKNLKKEYAGKCERVEALKGVVFDIYEGQI 512
Query: 837 TAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVR--SSMAAIRPHLGVCPQYNVLFD 894
TA LGH+GAGKTT L+ILSGL P+ GS + H + + + I G CPQ NV F
Sbjct: 513 TALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFG 572
Query: 895 MLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAF 954
LTV E++ + ++KG+ V E R++Q++ + + Q + ++LSGG RKL+ IA
Sbjct: 573 FLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAI 632
Query: 955 VGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGG 1014
+G QV++LDEPTAG+DP SR IW LL + + R ++ ST +DEA++L DR ++ G
Sbjct: 633 LGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFISNG 692
Query: 1015 RLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVG 1074
+L C GS LFL++ G GY+L+ L NE+ D +
Sbjct: 693 KLKCAGSSLFLKKKWGIGYHLS-------LHLNERCDPE--------------------- 724
Query: 1075 TPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGI 1134
+ +LV+ + A+L + +LV +LP F L+R+LD R + + YG+
Sbjct: 725 --SITSLVKQHISDAKLTAQSEEKLVYILPL--ERTNKFPELYRDLD-RCSNQGIEDYGV 779
Query: 1135 SDTSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAG 1194
S T+L E+FLK+ + D + + G GQ + + G
Sbjct: 780 SITTLNEVFLKLEGKSTID-ESDIGIWGQ---------------------LQTDGAKDIG 817
Query: 1195 SAPETDQ--GSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGL 1252
S E +Q S + + G AL RQQ+ A+ RFL ++ R+ L+ ++L +
Sbjct: 818 SLVELEQVLSSFHETRKTISGVALWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIP 877
Query: 1253 ALVFSLIVPPFGHYPALRLSPTMY 1276
L+ L + LSP Y
Sbjct: 878 QLLEHLFYESYQKSYPWELSPNTY 901
Score = 217 bits (552), Expect = 1e-55
Identities = 182/593 (30%), Positives = 283/593 (47%), Gaps = 64/593 (10%)
Query: 1551 ASFTLVLIEERVTRAK---HLQL-MGGLSPTLYWLGNFLWDMCNY-LVPACIVVLIFLAF 1605
ASFT + + K H QL + GL P+ YW G L D+ Y L+ + ++ ++
Sbjct: 1034 ASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFLILLLMQIMDYIFS 1093
Query: 1606 QQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMA 1665
+ NL +L + Y S+ L Y SF F + + L + I +A
Sbjct: 1094 PEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWSFFFLIVVIFSIVA 1153
Query: 1666 TFVLELFSDQKLQEVSRILKQVF--LIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQS 1723
T + E L F ++ P F L L + ++ D+ + LG +
Sbjct: 1154 TDLNEY----------GFLGLFFGTMLIPPFTLIGSLF--IFSEISPDSMDYLGASES-- 1199
Query: 1724 PLRWEVVGKNLLAMVIQGPLFLLFTLLLQ------HRSQLLPQPRVRSLPLLGE------ 1771
E+V LA++I FL+F +L+ + + P R P
Sbjct: 1200 ----EIV---YLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIFPNPE 1252
Query: 1772 ----EDEDVARERERVVQGATQGD-----VLVLRNLTKVYRGQRMP---------AVDRL 1813
E+ED+ ER R V D V++ L K Y G++ A +
Sbjct: 1253 EPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNV 1312
Query: 1814 CLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCP 1873
+ GE GLLG NGAGK++T +M+TGDT + G+ +L G S EP +GYCP
Sbjct: 1313 SFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKG-SGGGEPLGF---LGYCP 1368
Query: 1874 QSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRK 1933
Q +A++ LT R+HLE+ A ++G+ + + L L P T S G KRK
Sbjct: 1369 QENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRK 1428
Query: 1934 LATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREG-RSVMLTSHSMEECEALC 1992
L L+++G+P+VV LDEP+TGMDP ++ +W + A R R +LT+H M E EA+C
Sbjct: 1429 LCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVC 1488
Query: 1993 SRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVP-AARSQPAAAFVAAEFPGAELREAH 2051
R+AIMV+GR RC+GS QHLK +F + L +++ A+ +P A + FP A +E
Sbjct: 1489 DRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFPQAAQQERF 1548
Query: 2052 GGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKDQ 2104
+ ++LP L++ F +L + +E++S+SQ+ LE+VFL SK+Q
Sbjct: 1549 SSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQ 1601
Score = 167 bits (423), Expect = 1e-40
Identities = 154/610 (25%), Positives = 266/610 (43%), Gaps = 51/610 (8%)
Query: 1533 SVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYL 1592
+ D + C++ +F+ + V + + L M GL + +WL L L
Sbjct: 222 ATDFFIFFCIISFSTFI--YYVSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAGFIL 279
Query: 1593 VPACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLT 1652
+ A ++ LI + Q V + L LLYG S+ L + S P +V+
Sbjct: 280 IMATLMALIVKSAQ---IVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVF 336
Query: 1653 CINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADA 1712
+ +F GI G A + + L+ + F G+ ++ ++
Sbjct: 337 LLIVFWGILGFPALYT----------RLPAFLEWTLCLLSPFAFTVGMAQLIHLDYDVNS 386
Query: 1713 FERLGDRQFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQ--------HRSQLL------ 1758
L Q +P ++ L +V L+L+ TL HR L
Sbjct: 387 NAHLDSSQ--NPY---LIIATLFMLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSC 441
Query: 1759 ---PQPRVRSLPLLGEEDEDVARER--ERVVQGATQGDVLVLRNLTKVYRG--QRMPAVD 1811
R + L E D D E V + + ++NL K Y G +R+ A+
Sbjct: 442 FWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCGKEAIRIKNLKKEYAGKCERVEALK 501
Query: 1812 RLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSM-- 1869
+ I G+ LLG +GAGKT+ +++G ++ + G + H+++R ++S
Sbjct: 502 GVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFT 561
Query: 1870 GYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGG 1929
G+CPQS+ F LT +E+L L A+++G+ +V + + L + D A SGG
Sbjct: 562 GFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGG 621
Query: 1930 NKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECE 1989
RKL +A++GDP V+ LDEPT G+DP +R +WN LL + R ++ ++ ++E +
Sbjct: 622 QNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWN-LLKEGKSDRVILFSTQFIDEAD 680
Query: 1990 ALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRV-PAARSQPAAAFVAAEFPGAELR 2048
L R + NG+ +C GS LK ++ G+ L+L + + + V A+L
Sbjct: 681 ILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNERCDPESITSLVKQHISDAKLT 740
Query: 2049 EAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKDQGKDE 2108
+L + LP ++ +L + G+ED+ VS T L EVFL K +GK
Sbjct: 741 AQSEEKLVYILPLERTNKFPELYRDLD-RCSNQGIEDYGVSITTLNEVFL---KLEGK-- 794
Query: 2109 DTEEQKEAGV 2118
T ++ + G+
Sbjct: 795 STIDESDIGI 804
Score = 133 bits (334), Expect = 2e-30
Identities = 98/329 (29%), Positives = 155/329 (47%), Gaps = 38/329 (11%)
Query: 823 ALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPH 882
A R +S +G + LGHNGAGK+TT+ +++G P+ G + G +
Sbjct: 1308 ATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPLG----F 1363
Query: 883 LGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSG 942
LG CPQ N L+ LTV +H+ Y +KGL RL+ + L + + LS
Sbjct: 1364 LGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSE 1423
Query: 943 GMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELL-LKYRE-GRTLILSTHHLDE 1000
G++RKL ++ +G VV+LDEP+ G+DP ++ +W+++ +R R +L+TH++ E
Sbjct: 1424 GIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAE 1483
Query: 1001 AELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDT 1060
AE + DRVA++ GRL C GS L+ G Y L +
Sbjct: 1484 AEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEM----------------------- 1520
Query: 1061 RQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFREL 1120
+ KN +Q L A + P A E +V LP S A F +L
Sbjct: 1521 --KLKNLAQ-----MEPLHAEILRLFPQAAQQERFSSLMVYKLPVEDVRPLSQA--FFKL 1571
Query: 1121 DTRLAELRLTGYGISDTSLEEIFLKVVEE 1149
+ L Y +S ++LE++FL++ +E
Sbjct: 1572 EIVKQSFDLEEYSLSQSTLEQVFLELSKE 1600
>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
sapiens]
Length = 1543
Score = 277 bits (709), Expect = 7e-74
Identities = 215/716 (30%), Positives = 346/716 (48%), Gaps = 89/716 (12%)
Query: 557 AWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKL 616
++IY +L V RE+ + + M MGL + WL W L+ + + + + LV+
Sbjct: 146 SFIYFASLNV---ARERG-KFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALVITS 201
Query: 617 GDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVA 676
I+ ++ V+F + + ++ + +FL+S + LA G L F+++ +
Sbjct: 202 IPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFL--FTVFWGCLGFTV 259
Query: 677 WRDRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGL 736
+LP SLLSP AF G + L+ G + + P+ D + + +
Sbjct: 260 LYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFPD----PSGDSYKMIATFFI 315
Query: 737 LLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPR------------PPKSPA 784
L D Y + T Y E V P + G + F + S+W + P S
Sbjct: 316 LAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTHHEIFENEINPEHSSD 375
Query: 785 PCPTPLDPKVLVEEAPPGLSPGVSVRSLEKRFPGSPQP--ALRGLSLDFYQGHITAFLGH 842
P+ P+ +EA + +R++ K + G AL+G+ D Y+G ITA LGH
Sbjct: 376 DSFEPVSPEFHGKEA-------IRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGH 428
Query: 843 NGAGKTTTLSILSGLFPPSGGSAFILGHDVR--SSMAAIRPHLGVCPQYNVLFDMLTVDE 900
NGAGK+T L+ILSGL + GSA I + + M IR ++G CPQ+N FD LTV E
Sbjct: 429 NGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRE 488
Query: 901 HVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQV 960
++ + ++KG+ V E R++ ++ + S Q + + LSGG +RKL++ IA +G QV
Sbjct: 489 NLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQV 548
Query: 961 VILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCG 1020
++LDEPTAG+DP SR +W LL +++ R ++ ST +DEA++L DR ++ G+L C G
Sbjct: 549 LLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAG 608
Query: 1021 SPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLA 1080
S LFL+R G GY+L+L + NE DT+ ++ +
Sbjct: 609 SSLFLKRKWGIGYHLSLHR-------NEMCDTE-----------------------KITS 638
Query: 1081 LVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLE 1140
L++ +P A+L E +LV LP + F L+ +LD + ++ + Y +S TSL
Sbjct: 639 LIKQHIPDAKLTTESEEKLVYSLPLEKTN--KFPDLYSDLD-KCSDQGIRNYAVSVTSLN 695
Query: 1141 EIFLKVVEECAAD-TDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPET 1199
E+FL + + A D D + G + T G E+ +E + S PET
Sbjct: 696 EVFLNLEGKSAIDEPDFDIGKQEKIHVTRNTG-----------DESEME--QVLCSLPET 742
Query: 1200 DQGSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFA-QIVLPALFVGLAL 1254
+ V AL R+Q+ A+ RFL RR RR L +VL F+ + L
Sbjct: 743 RKA--------VSSAALWRRQIYAVATLRFLKLRRERRALLCLLLVLGIAFIPIIL 790
Score = 198 bits (503), Expect = 5e-50
Identities = 173/619 (27%), Positives = 294/619 (47%), Gaps = 80/619 (12%)
Query: 1542 VVFAMSFVPASFTLVLIEERVTR----------AKHLQL---MGGLSPTLYWLGNFLWDM 1588
+V + F+ S L+LI V+ K++Q + GL P+ YW G L D+
Sbjct: 926 IVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKKNVQSQLWISGLWPSAYWCGQALVDI 985
Query: 1589 CNYLVPA----CIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSV- 1643
Y + I IFL FQ ++ + L++ ++ S+ L Y SF F
Sbjct: 986 PLYFLILFSIHLIYYFIFLGFQ----LSWELMFVLVVCIIGCAVSLIFLTYVLSFIFRKW 1041
Query: 1644 -------PSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPHFCL 1696
+++L C++ + + ++++ IL +F+ P F L
Sbjct: 1042 RKNNGFWSFGFFIILICVST--------------IMVSTQYEKLNLILCMIFI--PSFTL 1085
Query: 1697 GRGLIDMVRNQAMADAFERLGDR--QFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQHR 1754
++ +++ M + + L +R + + + L +++ LF++ L +++
Sbjct: 1086 LGYVMLLIQLDFMRN-LDSLDNRINEVNKTILLTTLIPYLQSVIF---LFVIRCLEMKYG 1141
Query: 1755 SQLLPQ-------PRVRSL----PLLGEEDEDVARERERVVQGAT-----QGDVLVLRNL 1798
++++ + PR R EEDEDV ER + T + V+ L
Sbjct: 1142 NEIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCL 1201
Query: 1799 TKVY---------RGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRG 1849
K Y ++ A+ + + GE GLLG NGAGK+++ +M+TG T + G
Sbjct: 1202 HKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAG 1261
Query: 1850 EAVLAGH--SVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAG 1907
VL G SV ++ + +GYCPQ ++++ LT +EHLEL A ++G+ + A +
Sbjct: 1262 VVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSIS 1321
Query: 1908 SGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNS 1967
+ L L P T S G KRKL L+++G+P+VV LDEP TGMDP ++ +W
Sbjct: 1322 RLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQI 1381
Query: 1968 LLAVVR-EGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRV 2026
L A V+ + R +LT+H M E EA+C R+A+MV+G RC+GS QHLK +F + L +++
Sbjct: 1382 LQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKM 1441
Query: 2027 PAARSQPAA-AFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVED 2085
A + FP A +E + + ++LP L+R F +L +E+
Sbjct: 1442 KEPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLEE 1501
Query: 2086 FSVSQTMLEEVFLYFSKDQ 2104
+S+SQ LE+VFL K+Q
Sbjct: 1502 YSLSQATLEQVFLELCKEQ 1520
Score = 153 bits (386), Expect = 2e-36
Identities = 94/323 (29%), Positives = 169/323 (52%), Gaps = 7/323 (2%)
Query: 1791 DVLVLRNLTKVYRGQ--RMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASR 1848
+ + +RN+ K Y G+ ++ A+ + I G+ +LG NGAGK++ +++G ++++
Sbjct: 389 EAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTE 448
Query: 1849 GEAVLAGHSVAREPSAAHL--SMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTA 1906
G A + ++ + ++G+CPQ + F+ LT RE+L + A+++G+ +V Q
Sbjct: 449 GSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQEV 508
Query: 1907 GSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWN 1966
+ L + D A SGG KRKL +A++GDP V+ LDEPT G+DP +R +W
Sbjct: 509 KRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVW- 567
Query: 1967 SLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTL-R 2025
SLL + R ++ ++ M+E + L R + NG+ +C GS LK ++ G+ L+L R
Sbjct: 568 SLLKEHKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHR 627
Query: 2026 VPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVED 2085
++ + + P A+L +L + LP ++ +L ++ G+ +
Sbjct: 628 NEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDLYSDLD-KCSDQGIRN 686
Query: 2086 FSVSQTMLEEVFLYFSKDQGKDE 2108
++VS T L EVFL DE
Sbjct: 687 YAVSVTSLNEVFLNLEGKSAIDE 709
Score = 140 bits (354), Expect = 1e-32
Identities = 108/367 (29%), Positives = 170/367 (46%), Gaps = 51/367 (13%)
Query: 823 ALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGH--DVRSSMAAIR 880
A+R +S +G + LGHNGAGK+T++ +++G P+ G + G VR
Sbjct: 1221 AIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSL 1280
Query: 881 PHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHL 940
LG CPQ N L+ LT+ EH+ Y +KGL RL++ + L + + L
Sbjct: 1281 KFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTL 1340
Query: 941 SGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELL---LKYREGRTLILSTHH 997
S G++RKL ++ +G VV+LDEP G+DP ++ +W++L +K +E TL L+TH+
Sbjct: 1341 SEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTL-LTTHY 1399
Query: 998 LDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGS 1057
+ EAE + DR+A++ G L C GS L+ G Y L +
Sbjct: 1400 MSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEI-------------------- 1439
Query: 1058 VDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLF 1117
+ K +Q + T ++L L P A E + LP H S A F
Sbjct: 1440 -----KMKEPTQVEALHT-EILKL----FPQAAWQERYSSLMAYKLPVEDVHPLSRA--F 1487
Query: 1118 RELDTRLAELRLTGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLR 1177
+L+ L Y +S +LE++FL++ +E Q L +D T+
Sbjct: 1488 FKLEAMKQTFNLEEYSLSQATLEQVFLELCKE-------------QELGNVDDKIDTTVE 1534
Query: 1178 LKMPPQE 1184
K+ PQE
Sbjct: 1535 WKLLPQE 1541
>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 270 bits (689), Expect = 1e-71
Identities = 187/611 (30%), Positives = 303/611 (49%), Gaps = 69/611 (11%)
Query: 569 VVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPGVV 628
+V EKE ++++ ++ MGL WL W L L + L+ ++ + P S V+
Sbjct: 240 IVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVI 299
Query: 629 FLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGRVA 688
FL + +++V + +L+ F ++ G+ F + + + + + +
Sbjct: 300 FLLFFLYGLSSVFFALMLTPLFKKSKHV----GIVEFFVTVAFGFIGLMIILIESFPKSL 355
Query: 689 ASLLSPVA---FGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGLLLLDAALYG 745
L SP F G + LE+ EGA + N+ TA + L +L L++ Y
Sbjct: 356 VWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNL----TAGPYPLIITIIMLTLNSIFYV 411
Query: 746 LATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPK------------SPAPCPTPLDPK 793
L YL+ V PG++G+ + + SYW + S + P+ +
Sbjct: 412 LLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSE 471
Query: 794 VLVEEAPPGLSPGVSVRSLEKRF--PGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTL 851
+ +EA + + ++K + G ALR LS D Y+G ITA LGH+G GK+T +
Sbjct: 472 FVGKEA-------IRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLM 524
Query: 852 SILSGLFPPSGGSAFILGHDVRS--SMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLK 909
+IL GL PPS G A I GH V M R +G+CPQ ++ FD+LTV+E++ +K
Sbjct: 525 NILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIK 584
Query: 910 GLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAG 969
G+ A + E ++L D+ + + + Q + LSGG +RKLS+ IA +G ++++LDEPTAG
Sbjct: 585 GIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAG 644
Query: 970 VDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHL 1029
+DP SR +W LL + R + STH +DEA++L DR AV++ G L C GS +FL+
Sbjct: 645 MDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKW 704
Query: 1030 GSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGA 1089
G GY L++ +D T L +LV+ +PGA
Sbjct: 705 GIGYRLSMY-------------------ID-----------KYCATESLSSLVKQHIPGA 734
Query: 1090 RLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEE 1149
L+++ +LV LP+ F+ LF LD+ + L + YG+S T+LE++FLK+ E
Sbjct: 735 TLLQQNDQQLVYSLPFKDM--DKFSGLFSALDSH-SNLGVISYGVSMTTLEDVFLKL--E 789
Query: 1150 CAADTDMEDGS 1160
A+ D D S
Sbjct: 790 VEAEIDQADYS 800
Score = 200 bits (509), Expect = 1e-50
Identities = 166/633 (26%), Positives = 283/633 (44%), Gaps = 116/633 (18%)
Query: 1549 VPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQR 1608
+P F + E +A + GL P+ YW+G + D+ + + +++ LAF
Sbjct: 1035 MPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYG 1094
Query: 1609 AYVAPANLPALLLLLLLYGWSITPLMYPASFFF--------------SVPSTAYVVLTCI 1654
Y A++ L+ Y S+ Y ASF F SV + A + +T I
Sbjct: 1095 LYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEI 1154
Query: 1655 NLFIGINGSMATFVLELFSDQKLQEVSRILKQVF-LIFPHFCLGRGLIDMVRNQAMADAF 1713
F+G ++ IL F +I P + L LI ++
Sbjct: 1155 TFFMGYT------------------IATILHYAFCIIIPIYPLLGCLISFIK-------- 1188
Query: 1714 ERLGDRQFQSPLRWEVVGKNL--------LAMVIQGPLF--LLFTLLLQH---------- 1753
+ W+ V KN+ L++ + P +L+ LLQ+
Sbjct: 1189 -----------ISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSI 1237
Query: 1754 -------------RSQLLPQPRVRSLPLLGEEDEDVARERERV-----VQGATQGDVLVL 1795
+++ LP+P P +EDEDV ER +V Q + +++
Sbjct: 1238 RKDPFFRNLSTKSKNRKLPEP-----PDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMV 1292
Query: 1796 RNLTKVY---------RGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLA 1846
NL K Y R + A + + GE GLLG NGAGK++ ++ GD
Sbjct: 1293 SNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEP 1352
Query: 1847 SRGEAVLAGHSVAREPSAAHLS-MGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQT 1905
+ G+ L +S L MGYCPQ + ++ T +EH E+ ++G+ + + +
Sbjct: 1353 TSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEV 1412
Query: 1906 AGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLW 1965
L L + + G KRKL AL+++G+P + LDEP+TGMDP A++ +W
Sbjct: 1413 ISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMW 1472
Query: 1966 NSL-LAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTL 2024
++ A R+ +LT+H MEE EA+C R+AIMV+G+ RC+G+ QHLK +F G+ L +
Sbjct: 1473 RAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEI 1532
Query: 2025 R-------VPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVH 2077
+ + R Q ++ FP A +E+ L +++P +L++ F +L
Sbjct: 1533 KLKDWIENLEVDRLQREIQYI---FPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEA 1589
Query: 2078 GAEHGVEDFSVSQTMLEEVFLYFSKDQGKDEDT 2110
+E++S SQ LE+VF+ +K+Q +++++
Sbjct: 1590 KHAFAIEEYSFSQATLEQVFVELTKEQEEEDNS 1622
Score = 170 bits (431), Expect = 1e-41
Identities = 156/598 (26%), Positives = 259/598 (43%), Gaps = 71/598 (11%)
Query: 1540 ICVVFAMSFVPASFTLVL--IEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACI 1597
I + ++F P + L + + E+ + K + GL T +WL L
Sbjct: 221 ILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVL----------LY 270
Query: 1598 VVLIFLAFQQRAYVAPANLP-------ALLLLLLLYGWSITPLMYPASFFFSVPSTAYVV 1650
LIFL A +A A+L + LL LYG S + F +V
Sbjct: 271 TSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIV 330
Query: 1651 LTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMA 1710
+ + G G M ++E F K + +F FC +I + + +
Sbjct: 331 EFFVTVAFGFIGLMI-ILIESFP-----------KSLVWLFSPFCHCTFVIGIAQVMHLE 378
Query: 1711 DAFERLGDRQFQS---PLRWEVVGKNLLAMVIQGPLFLLFTLLLQHRSQLLPQP---RVR 1764
D E + PL ++ +++ + + LL + Q++P R
Sbjct: 379 DFNEGASFSNLTAGPYPL--------IITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRS 430
Query: 1765 SLPLLGEEDEDVA-RERERVVQGATQGDV------------------LVLRNLTKVYR-- 1803
SL L + R E + +G G++ + + + K YR
Sbjct: 431 SLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKK 490
Query: 1804 GQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAR--E 1861
G+ + A+ L I G+ LLG +G GK++ ++ G S G A + GH V+ E
Sbjct: 491 GENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDE 550
Query: 1862 PSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADR 1921
A +G CPQ D F++LT E+L +LA ++G+P + Q L L + D
Sbjct: 551 MFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDN 610
Query: 1922 PAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLT 1981
A SGG KRKL+ +A++G+P ++ LDEPT GMDP +R +WN LL + R + +
Sbjct: 611 QAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWN-LLKYRKANRVTVFS 669
Query: 1982 SHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPA-ARSQPAAAFVAA 2040
+H M+E + L R A++ G +C+GS LK ++ G+ L++ + ++ ++ V
Sbjct: 670 THFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLVKQ 729
Query: 2041 EFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFL 2098
PGA L + + +L + LP + +F L H + GV + VS T LE+VFL
Sbjct: 730 HIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSH-SNLGVISYGVSMTTLEDVFL 786
Score = 140 bits (353), Expect = 1e-32
Identities = 150/614 (24%), Positives = 260/614 (42%), Gaps = 76/614 (12%)
Query: 581 MRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPGVVFL---FLAA-FA 636
++ GL + W+G + + F + +L+L LG +L + H G+ F FLA F
Sbjct: 1055 LKLSGLLPSAYWIGQAVVDIPLFFI-----ILILMLGSLLAF-HYGLYFYTVKFLAVVFC 1108
Query: 637 VATVTQSFLLSAFFSRANLAAACGGLAYFSLY--LPYVLCVAWRDRLPAGGRVAASLLS- 693
+ S +L + + ++S + + C+A + G A++L
Sbjct: 1109 LIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFFMGYTIATILHY 1168
Query: 694 ------PVAFGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGLLLLDAALYGLA 747
P+ GC ++ ++ + + NV T D S+A +S L L+
Sbjct: 1169 AFCIIIPIYPLLGC-LISFIKISWKNVR-KNVDTYNPWDRLSVAVISPYL--QCVLWIFL 1224
Query: 748 TWYLEAVCPGQYGIPEPW--NFPFRRSYWCGPRPPKSPAPCPTPLDPKVLVEEAPPGL-- 803
Y E G+ +P+ N + P PP + ++ V+E
Sbjct: 1225 LQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCC 1284
Query: 804 --SPGVSVRSLEKRFPGSP---------QPALRGLSLDFYQGHITAFLGHNGAGKTTTLS 852
P + V +L K + + A + +S +G I LG NGAGK+T ++
Sbjct: 1285 EEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIIN 1344
Query: 853 ILSGLFPPSGGSAFILGHDVRSSMAAIRPH-LGVCPQYNVLFDMLTVDEHVWFYGRLKGL 911
IL G P+ G F+ + +S +G CPQ N L+ T+ EH YG +KG+
Sbjct: 1345 ILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGM 1404
Query: 912 SAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVD 971
SA+ + R+ + L + L G++RKL A++ +G Q+ +LDEP+ G+D
Sbjct: 1405 SASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMD 1464
Query: 972 PASRRGIWELL---LKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRH 1028
P +++ +W + K R+ R IL+TH+++EAE + DRVA++ G+L C G+ L+
Sbjct: 1465 PKAKQHMWRAIRTAFKNRK-RAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSK 1523
Query: 1029 LGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPG 1088
G GY+L + + D VD Q + +Q+ P
Sbjct: 1524 FGKGYFLEI----------KLKDWIENLEVDRLQRE-----------------IQYIFPN 1556
Query: 1089 ARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVE 1148
A E L +P S + F +L+ + Y S +LE++F+++ +
Sbjct: 1557 ASRQESFSSILAYKIPKEDVQ--SLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTK 1614
Query: 1149 ECAADTDMEDGSCG 1162
E + ED SCG
Sbjct: 1615 E----QEEEDNSCG 1624
Score = 37.7 bits (86), Expect = 0.12
Identities = 17/50 (34%), Positives = 27/50 (54%)
Query: 4 WTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHE 53
W Q LL KN++ + R + E+L+PLF F L+ + HP ++ E
Sbjct: 11 WRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEE 60
>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 270 bits (689), Expect = 1e-71
Identities = 187/611 (30%), Positives = 303/611 (49%), Gaps = 69/611 (11%)
Query: 569 VVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPGVV 628
+V EKE ++++ ++ MGL WL W L L + L+ ++ + P S V+
Sbjct: 240 IVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVI 299
Query: 629 FLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGRVA 688
FL + +++V + +L+ F ++ G+ F + + + + + +
Sbjct: 300 FLLFFLYGLSSVFFALMLTPLFKKSKHV----GIVEFFVTVAFGFIGLMIILIESFPKSL 355
Query: 689 ASLLSPVA---FGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGLLLLDAALYG 745
L SP F G + LE+ EGA + N+ TA + L +L L++ Y
Sbjct: 356 VWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNL----TAGPYPLIITIIMLTLNSIFYV 411
Query: 746 LATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPK------------SPAPCPTPLDPK 793
L YL+ V PG++G+ + + SYW + S + P+ +
Sbjct: 412 LLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSE 471
Query: 794 VLVEEAPPGLSPGVSVRSLEKRF--PGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTL 851
+ +EA + + ++K + G ALR LS D Y+G ITA LGH+G GK+T +
Sbjct: 472 FVGKEA-------IRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLM 524
Query: 852 SILSGLFPPSGGSAFILGHDVRS--SMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLK 909
+IL GL PPS G A I GH V M R +G+CPQ ++ FD+LTV+E++ +K
Sbjct: 525 NILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIK 584
Query: 910 GLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAG 969
G+ A + E ++L D+ + + + Q + LSGG +RKLS+ IA +G ++++LDEPTAG
Sbjct: 585 GIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAG 644
Query: 970 VDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHL 1029
+DP SR +W LL + R + STH +DEA++L DR AV++ G L C GS +FL+
Sbjct: 645 MDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKW 704
Query: 1030 GSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGA 1089
G GY L++ +D T L +LV+ +PGA
Sbjct: 705 GIGYRLSMY-------------------ID-----------KYCATESLSSLVKQHIPGA 734
Query: 1090 RLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEE 1149
L+++ +LV LP+ F+ LF LD+ + L + YG+S T+LE++FLK+ E
Sbjct: 735 TLLQQNDQQLVYSLPFKDM--DKFSGLFSALDSH-SNLGVISYGVSMTTLEDVFLKL--E 789
Query: 1150 CAADTDMEDGS 1160
A+ D D S
Sbjct: 790 VEAEIDQADYS 800
Score = 200 bits (509), Expect = 1e-50
Identities = 166/633 (26%), Positives = 283/633 (44%), Gaps = 116/633 (18%)
Query: 1549 VPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQR 1608
+P F + E +A + GL P+ YW+G + D+ + + +++ LAF
Sbjct: 1035 MPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYG 1094
Query: 1609 AYVAPANLPALLLLLLLYGWSITPLMYPASFFF--------------SVPSTAYVVLTCI 1654
Y A++ L+ Y S+ Y ASF F SV + A + +T I
Sbjct: 1095 LYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEI 1154
Query: 1655 NLFIGINGSMATFVLELFSDQKLQEVSRILKQVF-LIFPHFCLGRGLIDMVRNQAMADAF 1713
F+G ++ IL F +I P + L LI ++
Sbjct: 1155 TFFMGYT------------------IATILHYAFCIIIPIYPLLGCLISFIK-------- 1188
Query: 1714 ERLGDRQFQSPLRWEVVGKNL--------LAMVIQGPLF--LLFTLLLQH---------- 1753
+ W+ V KN+ L++ + P +L+ LLQ+
Sbjct: 1189 -----------ISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSI 1237
Query: 1754 -------------RSQLLPQPRVRSLPLLGEEDEDVARERERV-----VQGATQGDVLVL 1795
+++ LP+P P +EDEDV ER +V Q + +++
Sbjct: 1238 RKDPFFRNLSTKSKNRKLPEP-----PDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMV 1292
Query: 1796 RNLTKVY---------RGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLA 1846
NL K Y R + A + + GE GLLG NGAGK++ ++ GD
Sbjct: 1293 SNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEP 1352
Query: 1847 SRGEAVLAGHSVAREPSAAHLS-MGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQT 1905
+ G+ L +S L MGYCPQ + ++ T +EH E+ ++G+ + + +
Sbjct: 1353 TSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEV 1412
Query: 1906 AGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLW 1965
L L + + G KRKL AL+++G+P + LDEP+TGMDP A++ +W
Sbjct: 1413 ISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMW 1472
Query: 1966 NSL-LAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTL 2024
++ A R+ +LT+H MEE EA+C R+AIMV+G+ RC+G+ QHLK +F G+ L +
Sbjct: 1473 RAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEI 1532
Query: 2025 R-------VPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVH 2077
+ + R Q ++ FP A +E+ L +++P +L++ F +L
Sbjct: 1533 KLKDWIENLEVDRLQREIQYI---FPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEA 1589
Query: 2078 GAEHGVEDFSVSQTMLEEVFLYFSKDQGKDEDT 2110
+E++S SQ LE+VF+ +K+Q +++++
Sbjct: 1590 KHAFAIEEYSFSQATLEQVFVELTKEQEEEDNS 1622
Score = 170 bits (431), Expect = 1e-41
Identities = 156/598 (26%), Positives = 259/598 (43%), Gaps = 71/598 (11%)
Query: 1540 ICVVFAMSFVPASFTLVL--IEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACI 1597
I + ++F P + L + + E+ + K + GL T +WL L
Sbjct: 221 ILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVL----------LY 270
Query: 1598 VVLIFLAFQQRAYVAPANLP-------ALLLLLLLYGWSITPLMYPASFFFSVPSTAYVV 1650
LIFL A +A A+L + LL LYG S + F +V
Sbjct: 271 TSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIV 330
Query: 1651 LTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMA 1710
+ + G G M ++E F K + +F FC +I + + +
Sbjct: 331 EFFVTVAFGFIGLMI-ILIESFP-----------KSLVWLFSPFCHCTFVIGIAQVMHLE 378
Query: 1711 DAFERLGDRQFQS---PLRWEVVGKNLLAMVIQGPLFLLFTLLLQHRSQLLPQP---RVR 1764
D E + PL ++ +++ + + LL + Q++P R
Sbjct: 379 DFNEGASFSNLTAGPYPL--------IITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRS 430
Query: 1765 SLPLLGEEDEDVA-RERERVVQGATQGDV------------------LVLRNLTKVYR-- 1803
SL L + R E + +G G++ + + + K YR
Sbjct: 431 SLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKK 490
Query: 1804 GQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAR--E 1861
G+ + A+ L I G+ LLG +G GK++ ++ G S G A + GH V+ E
Sbjct: 491 GENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDE 550
Query: 1862 PSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADR 1921
A +G CPQ D F++LT E+L +LA ++G+P + Q L L + D
Sbjct: 551 MFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDN 610
Query: 1922 PAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLT 1981
A SGG KRKL+ +A++G+P ++ LDEPT GMDP +R +WN LL + R + +
Sbjct: 611 QAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWN-LLKYRKANRVTVFS 669
Query: 1982 SHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPA-ARSQPAAAFVAA 2040
+H M+E + L R A++ G +C+GS LK ++ G+ L++ + ++ ++ V
Sbjct: 670 THFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLVKQ 729
Query: 2041 EFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFL 2098
PGA L + + +L + LP + +F L H + GV + VS T LE+VFL
Sbjct: 730 HIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSH-SNLGVISYGVSMTTLEDVFL 786
Score = 140 bits (353), Expect = 1e-32
Identities = 150/614 (24%), Positives = 260/614 (42%), Gaps = 76/614 (12%)
Query: 581 MRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPGVVFL---FLAA-FA 636
++ GL + W+G + + F + +L+L LG +L + H G+ F FLA F
Sbjct: 1055 LKLSGLLPSAYWIGQAVVDIPLFFI-----ILILMLGSLLAF-HYGLYFYTVKFLAVVFC 1108
Query: 637 VATVTQSFLLSAFFSRANLAAACGGLAYFSLY--LPYVLCVAWRDRLPAGGRVAASLLS- 693
+ S +L + + ++S + + C+A + G A++L
Sbjct: 1109 LIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFFMGYTIATILHY 1168
Query: 694 ------PVAFGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGLLLLDAALYGLA 747
P+ GC ++ ++ + + NV T D S+A +S L L+
Sbjct: 1169 AFCIIIPIYPLLGC-LISFIKISWKNVR-KNVDTYNPWDRLSVAVISPYL--QCVLWIFL 1224
Query: 748 TWYLEAVCPGQYGIPEPW--NFPFRRSYWCGPRPPKSPAPCPTPLDPKVLVEEAPPGL-- 803
Y E G+ +P+ N + P PP + ++ V+E
Sbjct: 1225 LQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCC 1284
Query: 804 --SPGVSVRSLEKRFPGSP---------QPALRGLSLDFYQGHITAFLGHNGAGKTTTLS 852
P + V +L K + + A + +S +G I LG NGAGK+T ++
Sbjct: 1285 EEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIIN 1344
Query: 853 ILSGLFPPSGGSAFILGHDVRSSMAAIRPH-LGVCPQYNVLFDMLTVDEHVWFYGRLKGL 911
IL G P+ G F+ + +S +G CPQ N L+ T+ EH YG +KG+
Sbjct: 1345 ILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGM 1404
Query: 912 SAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVD 971
SA+ + R+ + L + L G++RKL A++ +G Q+ +LDEP+ G+D
Sbjct: 1405 SASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMD 1464
Query: 972 PASRRGIWELL---LKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRH 1028
P +++ +W + K R+ R IL+TH+++EAE + DRVA++ G+L C G+ L+
Sbjct: 1465 PKAKQHMWRAIRTAFKNRK-RAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSK 1523
Query: 1029 LGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPG 1088
G GY+L + + D VD Q + +Q+ P
Sbjct: 1524 FGKGYFLEI----------KLKDWIENLEVDRLQRE-----------------IQYIFPN 1556
Query: 1089 ARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVE 1148
A E L +P S + F +L+ + Y S +LE++F+++ +
Sbjct: 1557 ASRQESFSSILAYKIPKEDVQ--SLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTK 1614
Query: 1149 ECAADTDMEDGSCG 1162
E + ED SCG
Sbjct: 1615 E----QEEEDNSCG 1624
Score = 37.7 bits (86), Expect = 0.12
Identities = 17/50 (34%), Positives = 27/50 (54%)
Query: 4 WTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHE 53
W Q LL KN++ + R + E+L+PLF F L+ + HP ++ E
Sbjct: 11 WRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEE 60
>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
sapiens]
Length = 1617
Score = 257 bits (657), Expect = 8e-68
Identities = 212/797 (26%), Positives = 366/797 (45%), Gaps = 102/797 (12%)
Query: 484 WDPGPAADPLTDLRYVWGGFVYLQDLVERAAVR------VLSGANPRAGLYLQQMPYPCY 537
WD G T +Y GFV LQ + A + V+ + ++ +P+
Sbjct: 157 WD-GYGEFSCTLTKYWNRGFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPF--- 212
Query: 538 VDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFL 597
+ +L + + L + + V ++ + ++ M+ MGL + WL W L
Sbjct: 213 ---ITKNLLHNEMFILFFLLHFSPLVYFISLNVTKERKKSKNLMKMMGLQDSAFWLSWGL 269
Query: 598 SCLGPFLLSAALLVLVLKLGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAA 657
G + + + +++ I+ + V+F+ + ++ V FL+S +A L
Sbjct: 270 IYAGFIFIISIFVTIIITFTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLT- 328
Query: 658 ACGGLAYFSLYLPYVLCVAWR---DRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGA 714
L F L L + C+ + ++LP+ ++ SP AF G + L+ G
Sbjct: 329 ---NLVVFLLTL-FWGCLGFTVFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGV 384
Query: 715 QWHNVGTRPTADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWN-FPFRRSY 773
+ + P+ D +++ +LLLD +Y L Y + + P YG ++ F S
Sbjct: 385 IFPD----PSGDSYTMIATFSMLLLDGLIYLLLALYFDKILP--YGDERHYSPLFFLNSS 438
Query: 774 WCGPRPPKSPAPCPTPLDPKVLVEEAPPGLSP------GVSVRSLEKRFPGSPQP--ALR 825
C + +D + ++ ++P + +R+++K + G AL+
Sbjct: 439 SCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEALK 498
Query: 826 GLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRS--SMAAIRPHL 883
GL D Y+G ITA LGH+GAGK++ L+IL+GL P+ GS I ++ + IR
Sbjct: 499 GLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKIT 558
Query: 884 GVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGG 943
GVCPQ+NV FD+LTV E++ + ++KG+ V E R+L ++ + + Q +HLS G
Sbjct: 559 GVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEG 618
Query: 944 MQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAEL 1003
+RKL+ I +G Q+++LDEPT G+DP SR +W LL + R ++ ST +DEA++
Sbjct: 619 QKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVILFSTQSMDEADI 678
Query: 1004 LGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQE 1063
L DR +++ GRL C GS +FL+R G GY+L+L + NE + +
Sbjct: 679 LADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHR-------NEICNPE---------- 721
Query: 1064 KKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTR 1123
Q+ + + H +P A+L E +LV LP + +F LF +LD +
Sbjct: 722 -------------QITSFITHHIPDAKLKTENKEKLVYTLPLERTN--TFPDLFSDLD-K 765
Query: 1124 LAELRLTGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQ 1183
++ +TGY IS ++L E+F+K+ + + D E +++M
Sbjct: 766 CSDQGVTGYDISMSTLNEVFMKLEGQSTIEQDFE-------------------QVEMIRD 806
Query: 1184 ETALENGEPAGSAPETDQGSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFAQI 1243
+L E A S+ Q + V L R Q+ A+ RFL +R ++
Sbjct: 807 SESLNEMELAHSSFSEMQTA-------VSDMGLWRMQVFAMARLRFLKLKRQ-----TKV 854
Query: 1244 VLPALFVGLALVFSLIV 1260
+L L V +F LIV
Sbjct: 855 LLTLLLVFGIAIFPLIV 871
Score = 210 bits (534), Expect = 1e-53
Identities = 192/687 (27%), Positives = 300/687 (43%), Gaps = 102/687 (14%)
Query: 1476 NNKGWHSMVAFVNRASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVD 1535
N K H +N SN +L+ H I + P L+ L G L S
Sbjct: 967 NTKRLHCFPILMNIISNGLLQMF------NHTQHIRIESSPFPLSHIGLWTG-LPDGSFF 1019
Query: 1536 VLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPA 1595
+ + +C + T+ I + AK + GL + YW G L D+ +++
Sbjct: 1020 LFLVLCSISPY------ITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILIL 1073
Query: 1596 CIVVLIF-LAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASF--------------F 1640
++ LIF + Q + + AL+++ Y S+ +Y SF +
Sbjct: 1074 LLMYLIFYIENMQYLLITSQIVFALVIVTPGYAASLVFFIYMISFIFRKRRKNSGLWSFY 1133
Query: 1641 FSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPHFCLGRGL 1700
F ST +T IN F ++S ++ + L+ + LG
Sbjct: 1134 FFFASTIMFSITLINHF---------------------DLSILITTMVLVPSYTLLGFKT 1172
Query: 1701 IDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQHRSQLLPQ 1760
VR+Q F +E+ + L I LLF +L+ +
Sbjct: 1173 FLEVRDQEHYREFPEAN---------FELSATDFLVCFIPYFQTLLFVFVLRCMELKCGK 1223
Query: 1761 PRVRSLPLLG----------------EEDEDVARERERVVQGAT-----QGDVLVLRNLT 1799
R+R P+ +EDED+ ER R T + V++ L
Sbjct: 1224 KRMRKDPVFRISPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLH 1283
Query: 1800 KVYRGQRMP---------AVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGE 1850
K Y GQ+ A + + GE GLLG NGAGK+S+ RM++G T + GE
Sbjct: 1284 KEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGE 1343
Query: 1851 AVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGL 1910
L G S HL GYCPQ + ++ +LT REHLE+ A ++G+ +A +
Sbjct: 1344 VELKGCSSV----LGHL--GYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLV 1397
Query: 1911 ARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLA 1970
+ L + P + G RKL L+L+G+ V+ LDEP+TG+DP+ ++ +W ++ A
Sbjct: 1398 SAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQA 1457
Query: 1971 VVRE-GRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAA 2029
VV+ R V+LT+H++ E EALC R+AIMV+GR RC+GS QHLK + + L L+V
Sbjct: 1458 VVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKV--- 1514
Query: 2030 RSQPAAAFVAAE----FPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVED 2085
+ V E FP A +E + L ++LP L++ F +L +E+
Sbjct: 1515 KETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEE 1574
Query: 2086 FSVSQTMLEEVFLYFSKDQGKDEDTEE 2112
+S+SQ LE+VFL SK+Q EE
Sbjct: 1575 YSLSQCTLEKVFLELSKEQEVGNFDEE 1601
Score = 171 bits (434), Expect = 5e-42
Identities = 158/636 (24%), Positives = 280/636 (44%), Gaps = 60/636 (9%)
Query: 1512 TLNHPLNLTKEQLSEGALMASSVDVLVS-------ICVVFAMSFVPASFTLVL-IEERVT 1563
T NHP+ +E +S A+ ++ + + F + F P + + L + +
Sbjct: 190 TTNHPV--MEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYFISLNVTKERK 247
Query: 1564 RAKHLQLMGGLSPTLYWLGNFLWDM--CNYLVPACIVVLIFLAFQQRAYVAPANLPALLL 1621
++K+L M GL + +WL W + ++ I V I + F Q + + +
Sbjct: 248 KSKNLMKMMGLQDSAFWLS---WGLIYAGFIFIISIFVTIIITFTQ--IIVMTGFMVIFI 302
Query: 1622 LLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQEVS 1681
L LYG S+ L++ S +V+ + LF G G + +++
Sbjct: 303 LFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFY----------EQLP 352
Query: 1682 RILKQVFLIFPHFCLGRGLIDMVRNQAMADAF---ERLGDRQFQ----SPLRWEVVGKNL 1734
L+ + I F G+I +++ + + GD S L + + L
Sbjct: 353 SSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLIYLL 412
Query: 1735 LAMVIQ-----------GPLFLLFTLLLQHRSQLLPQPRVRSLPLLGEED-EDVARERER 1782
LA+ PLF L + S R + + E D E + +
Sbjct: 413 LALYFDKILPYGDERHYSPLFFL------NSSSCFQHQRTNAKVIEKEIDAEHPSDDYFE 466
Query: 1783 VVQGATQG-DVLVLRNLTKVYRGQ--RMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRM 1839
V QG + + +RN+ K Y+G+ ++ A+ L I G+ +LG +GAGK+S +
Sbjct: 467 PVAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNI 526
Query: 1840 VTGDTLASRGEAVLAGHSVAREPSAAHLSM--GYCPQSDAIFELLTGREHLELLARLRGV 1897
+ G ++ + G + +++ + G CPQ + F++LT +E+L L A+++G+
Sbjct: 527 LNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGI 586
Query: 1898 PEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMD 1957
+V Q L L + D A S G KRKL + ++GDP ++ LDEPTTG+D
Sbjct: 587 HLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLD 646
Query: 1958 PSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFA 2017
P +R +W SLL R ++ ++ SM+E + L R IM NGR +C GS LK R+
Sbjct: 647 PFSRDQVW-SLLRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWG 705
Query: 2018 AGHTLTL-RVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAV 2076
G+ L+L R + +F+ P A+L+ + +L + LP +F +L
Sbjct: 706 LGYHLSLHRNEICNPEQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLD- 764
Query: 2077 HGAEHGVEDFSVSQTMLEEVFLYFSKDQGKDEDTEE 2112
++ GV + +S + L EVF+ ++D E+
Sbjct: 765 KCSDQGVTGYDISMSTLNEVFMKLEGQSTIEQDFEQ 800
Score = 148 bits (373), Expect = 6e-35
Identities = 113/363 (31%), Positives = 177/363 (48%), Gaps = 55/363 (15%)
Query: 823 ALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPH 882
A R +S +G I LG NGAGK++++ ++SG+ P+ G + G +++ H
Sbjct: 1302 AARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG------CSSVLGH 1355
Query: 883 LGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSG 942
LG CPQ NVL+ MLT+ EH+ Y +KGL A RL+ L + +V + L+
Sbjct: 1356 LGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTA 1415
Query: 943 GMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELL---LKYREGRTLILSTHHLD 999
G+ RKL ++ +G S V++LDEP+ G+DP ++ +W+ + +K E R ++L+TH+L
Sbjct: 1416 GITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTE-RGVLLTTHNLA 1474
Query: 1000 EAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVD 1059
EAE L DRVA++ GRL C GS L+ LG Y L L
Sbjct: 1475 EAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILEL---------------------- 1512
Query: 1060 TRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRE 1119
+ K SQ + V T ++L L P A E L LP + + F +
Sbjct: 1513 ---KVKETSQVTLVHT-EILKL----FPQAAGQERYSSLLTYKLPVADVY--PLSQTFHK 1562
Query: 1120 LDTRLAELRLTGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLK 1179
L+ L Y +S +LE++FL++ +E E G+ + +D T+R K
Sbjct: 1563 LEAVKHNFNLEEYSLSQCTLEKVFLELSKE------QEVGNFDEE-------IDTTMRWK 1609
Query: 1180 MPP 1182
+ P
Sbjct: 1610 LLP 1612
>gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sapiens]
Length = 1581
Score = 224 bits (572), Expect = 5e-58
Identities = 219/800 (27%), Positives = 344/800 (43%), Gaps = 140/800 (17%)
Query: 502 GFVYLQDLVERAAVRV------------LSGANPRAGLYLQQMPYPCYVDDVFLRVLSRS 549
GFV LQ + A + + ++G N + ++ Q + D++L S
Sbjct: 176 GFVALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGV---ITDLYLFSCIIS 232
Query: 550 LPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAAL 609
F+ A SV +T RE++ R++ M MGL + WL W L G + A
Sbjct: 233 FSSFIYYA---SVNVT-----RERK-RMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALF 283
Query: 610 LVLVLKLGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYL 669
L LV++ + S VVF + ++ V +FL+S ++ L GL F L +
Sbjct: 284 LALVIRSTQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLT----GLVVFLLTV 339
Query: 670 PYVLCVAWRD---RLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTAD 726
+ C+ + LPA SLLSP AF G L L+ N P+
Sbjct: 340 -FWGCLGFTSLYRHLPASLEWILSLLSPFAFMLGMAQLLHLDYDLNS----NAFPHPSDG 394
Query: 727 VFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPKSPA-P 785
+ + +L D LY Y E + P +YG P F + S+W + A
Sbjct: 395 SNLIVATNFMLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALE 454
Query: 786 CPTPLDPKV--LVEEAPPGLS--PGVSVRSLEKRFPGSPQP--ALRGLSLDFYQGHITAF 839
DP E+APP + +R++ K + G P AL+ L D Y+G ITA
Sbjct: 455 DEMDADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAI 514
Query: 840 LGHNGAGKTTTLSILSGLFPPSGGSAFILGHDV--RSSMAAIRPHLGVCPQYNVLFDMLT 897
LGH+GAGK+T L+ILSGL P+ GS I + + + + + GVCPQ NV FD LT
Sbjct: 515 LGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLT 574
Query: 898 VDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGG 957
V E++ + ++KG+ L Q+V
Sbjct: 575 VRENLRLFAKIKGI-----------LPQEV-----------------------------D 594
Query: 958 SQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLC 1017
++ +LDEPTAG+DP SR +W LL + + R ++ ST +DEA++L DR ++ G+L
Sbjct: 595 KEIFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLSQGKLK 654
Query: 1018 CCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQ 1077
C GS LFL++ G GY+L+L + + N
Sbjct: 655 CAGSSLFLKKKWGIGYHLSLQLNEICVEEN------------------------------ 684
Query: 1078 LLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDT 1137
+ +LV+ +P A+L + +L+ LP F L+++LD+ +L + YG+S T
Sbjct: 685 ITSLVKQHIPDAKLSAKSEGKLIYTLPL--ERTNKFPELYKDLDS-YPDLGIENYGVSMT 741
Query: 1138 SLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAP 1197
+L E+FLK+ + + + IA L K E +E + S
Sbjct: 742 TLNEVFLKLEGKSTINE------------SDIAILGEVQAEKADDTERLVEMEQVLSSLN 789
Query: 1198 ETDQGSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFA-QIVLPALFVGLALVF 1256
+ + G G AL RQQ+ A+ R L + R+ L A ++L A F L + +
Sbjct: 790 KMRKTIG--------GVALWRQQICAIARVRLLKLKHERKALLALLLILMAGFCPLLVEY 841
Query: 1257 SLIVPPFGHYPALRLSPTMY 1276
+++ Y LSP +Y
Sbjct: 842 TMVKIYQNSY-TWELSPHLY 860
Score = 214 bits (545), Expect = 7e-55
Identities = 178/606 (29%), Positives = 280/606 (46%), Gaps = 88/606 (14%)
Query: 1547 SFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQ 1606
S P + I++ RA+ + GLSP+ YW G L D+ Y L+F+
Sbjct: 993 SSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYF-------LVFVFIY 1045
Query: 1607 QRAYVAPANLPALLLLLLL---------YGWSITPLMYPASFFF-------SVPSTAYVV 1650
+Y++ N +LL ++ Y +S+ + Y SF F + S + V
Sbjct: 1046 LMSYIS--NFEDMLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFRKGRKNSGIWSFCFYV 1103
Query: 1651 LTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMA 1710
+T S+A F +F ++ I FLI P +G + +
Sbjct: 1104 VTVF--------SVAGFAFSIFES----DIPFIF--TFLIPPATMIGCLFLSSHLLFSSL 1149
Query: 1711 DAFERLGDRQFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQ------HRSQLLPQPRVR 1764
+ ER+ + F L +I F++F L+ + + P R
Sbjct: 1150 FSEERMDVQPF-------------LVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFR 1196
Query: 1765 SLPLLGE----------EDEDVARERERVVQGATQGD-----VLVLRNLTKVYRGQRMP- 1808
P + EDEDV ER R + V++ L K Y G+R
Sbjct: 1197 ISPRSSDVCQNPEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGC 1256
Query: 1809 --------AVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAR 1860
A + + GE GLLG NGAGK+++ +++TGDT + G+ +L G
Sbjct: 1257 FSKRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSG--- 1313
Query: 1861 EPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYAD 1920
A +GYCPQ +A++ LT R+HLE+ A ++G+ + + L L
Sbjct: 1314 -GGDALEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLK 1372
Query: 1921 RPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREG-RSVM 1979
P T S G KRKL L+++G+P+VV LDEP+TGMDP ++ +W ++ A R R +
Sbjct: 1373 SPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGAL 1432
Query: 1980 LTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVP-AARSQPAAAFV 2038
LT+H M E EA+C R+AIMV+GR RC+GS QHLK +F + L ++V A+ +P A +
Sbjct: 1433 LTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAEI 1492
Query: 2039 AAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFL 2098
FP A +E + + ++LP LA+ F +L +E++S+SQ+ LE+VFL
Sbjct: 1493 LRLFPQAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFL 1552
Query: 2099 YFSKDQ 2104
SK+Q
Sbjct: 1553 ELSKEQ 1558
Score = 133 bits (334), Expect = 2e-30
Identities = 103/364 (28%), Positives = 165/364 (45%), Gaps = 51/364 (14%)
Query: 823 ALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPH 882
A R +S +G + LGHNGAGK+T++ +++G P+ G + G ++
Sbjct: 1265 ATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALE----F 1320
Query: 883 LGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSG 942
LG CPQ N L+ LTV +H+ Y +KGL RL+ + L + + LS
Sbjct: 1321 LGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSE 1380
Query: 943 GMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELL-LKYRE-GRTLILSTHHLDE 1000
G++RKL ++ +G VV+LDEP+ G+DP ++ +W+ + +R R +L+TH++ E
Sbjct: 1381 GIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAE 1440
Query: 1001 AELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDT 1060
AE + DRVA++ GRL C GS L+ G Y L +
Sbjct: 1441 AEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEM----------------------- 1477
Query: 1061 RQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFREL 1120
+ KN +Q L A + P A E +V LP A F +L
Sbjct: 1478 --KVKNLAQ-----VEPLHAEILRLFPQAARQERYSSLMVYKLPVEDVQ--PLAQAFFKL 1528
Query: 1121 DTRLAELRLTGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKM 1180
+ L Y +S ++LE++FL++ +E ED D +++ K+
Sbjct: 1529 EKVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDFEED-------------FDPSVKWKL 1575
Query: 1181 PPQE 1184
PQE
Sbjct: 1576 LPQE 1579
Score = 128 bits (322), Expect = 5e-29
Identities = 140/608 (23%), Positives = 252/608 (41%), Gaps = 103/608 (16%)
Query: 1535 DVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVP 1594
D+ + C++ SF+ + V E + R K L M GL + +WL W +
Sbjct: 223 DLYLFSCIISFSSFIYYASVNVTRERK--RMKALMTMMGLRDSAFWLS---WGLLYAGFI 277
Query: 1595 ACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCI 1654
+ + + L + ++ + + L LLYG S+ L + S +V+ +
Sbjct: 278 FIMALFLALVIRSTQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLL 337
Query: 1655 NLFIGINGSMATF---------VLELFSDQKLQ-EVSRILKQVFLI----FPHFCLGRGL 1700
+F G G + + +L L S ++++L + + FPH G L
Sbjct: 338 TVFWGCLGFTSLYRHLPASLEWILSLLSPFAFMLGMAQLLHLDYDLNSNAFPHPSDGSNL 397
Query: 1701 I---------DMVRNQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQGPLFLL---FT 1748
I D A+A FE++ ++ + PLF L F
Sbjct: 398 IVATNFMLAFDTCLYLALAIYFEKILPNEYGHR---------------RPPLFFLKSSFW 442
Query: 1749 LLLQHRSQLLPQPRVRSLPLLGEEDEDVARERERVVQGATQGDVLVLRNLTKVYRGQ--R 1806
Q + + + + P + E E QG + + +RN+TK Y+G+ +
Sbjct: 443 SQTQKTDHVALEDEMDADPSFHDSFEQAPPE----FQGK---EAIRIRNVTKEYKGKPDK 495
Query: 1807 MPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAH 1866
+ A+ L I G+ +LG +GAGK++ +++G ++ ++G + + ++ +
Sbjct: 496 IEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLEN 555
Query: 1867 LSM--GYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAG 1924
LS G CPQS+ F+ LT RE+L L A+++G+ +V
Sbjct: 556 LSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEV---------------------- 593
Query: 1925 TYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHS 1984
D + LDEPT G+DP +R +WN LL + R ++ ++
Sbjct: 594 ------------------DKEIFLLDEPTAGLDPFSRHQVWN-LLKERKTDRVILFSTQF 634
Query: 1985 MEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRV-PAARSQPAAAFVAAEFP 2043
M+E + L R + G+ +C GS LK ++ G+ L+L++ + + V P
Sbjct: 635 MDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEICVEENITSLVKQHIP 694
Query: 2044 GAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKD 2103
A+L G+L + LP ++ +L + + G+E++ VS T L EVFL K
Sbjct: 695 DAKLSAKSEGKLIYTLPLERTNKFPELYKDLDSY-PDLGIENYGVSMTTLNEVFL---KL 750
Query: 2104 QGKDEDTE 2111
+GK E
Sbjct: 751 EGKSTINE 758
>gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 155 bits (392), Expect = 4e-37
Identities = 79/164 (48%), Positives = 109/164 (66%), Gaps = 1/164 (0%)
Query: 1882 LTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALV 1941
+T +E + + AR+ GV E Q+ L L L +A R TYS GNKR+L+TA+AL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1942 GDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNG 2001
G +V+FLDEP+TGMDP ARR LWN + G+++++TSHSMEEC+ALC+ LAIMV G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 2002 RFRCLGSPQHLKGRFAAGHTLTLRVPAA-RSQPAAAFVAAEFPG 2044
+F CLGSPQHLK +F + L ++V + + +VA FPG
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFPG 164
Score = 93.2 bits (230), Expect = 2e-18
Identities = 48/141 (34%), Positives = 82/141 (58%), Gaps = 1/141 (0%)
Query: 896 LTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFV 955
+T E + Y R+ G+S +G ++ L + L S + S G +R+LS AIA +
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 956 GGSQVVILDEPTAGVDPASRRGIWELLLKYRE-GRTLILSTHHLDEAELLGDRVAVVAGG 1014
G S V+ LDEP+ G+DP +RR +W ++ K RE G+ +++++H ++E + L +A++ G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 1015 RLCCCGSPLFLRRHLGSGYYL 1035
+ C GSP L+ G+ Y L
Sbjct: 121 KFTCLGSPQHLKSKFGNIYIL 141
>gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 155 bits (392), Expect = 4e-37
Identities = 79/164 (48%), Positives = 109/164 (66%), Gaps = 1/164 (0%)
Query: 1882 LTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALV 1941
+T +E + + AR+ GV E Q+ L L L +A R TYS GNKR+L+TA+AL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1942 GDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNG 2001
G +V+FLDEP+TGMDP ARR LWN + G+++++TSHSMEEC+ALC+ LAIMV G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 2002 RFRCLGSPQHLKGRFAAGHTLTLRVPAA-RSQPAAAFVAAEFPG 2044
+F CLGSPQHLK +F + L ++V + + +VA FPG
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFPG 164
Score = 93.2 bits (230), Expect = 2e-18
Identities = 48/141 (34%), Positives = 82/141 (58%), Gaps = 1/141 (0%)
Query: 896 LTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFV 955
+T E + Y R+ G+S +G ++ L + L S + S G +R+LS AIA +
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 956 GGSQVVILDEPTAGVDPASRRGIWELLLKYRE-GRTLILSTHHLDEAELLGDRVAVVAGG 1014
G S V+ LDEP+ G+DP +RR +W ++ K RE G+ +++++H ++E + L +A++ G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 1015 RLCCCGSPLFLRRHLGSGYYL 1035
+ C GSP L+ G+ Y L
Sbjct: 121 KFTCLGSPQHLKSKFGNIYIL 141
>gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 155 bits (392), Expect = 4e-37
Identities = 79/164 (48%), Positives = 109/164 (66%), Gaps = 1/164 (0%)
Query: 1882 LTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALV 1941
+T +E + + AR+ GV E Q+ L L L +A R TYS GNKR+L+TA+AL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1942 GDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNG 2001
G +V+FLDEP+TGMDP ARR LWN + G+++++TSHSMEEC+ALC+ LAIMV G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 2002 RFRCLGSPQHLKGRFAAGHTLTLRVPAA-RSQPAAAFVAAEFPG 2044
+F CLGSPQHLK +F + L ++V + + +VA FPG
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFPG 164
Score = 93.2 bits (230), Expect = 2e-18
Identities = 48/141 (34%), Positives = 82/141 (58%), Gaps = 1/141 (0%)
Query: 896 LTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFV 955
+T E + Y R+ G+S +G ++ L + L S + S G +R+LS AIA +
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 956 GGSQVVILDEPTAGVDPASRRGIWELLLKYRE-GRTLILSTHHLDEAELLGDRVAVVAGG 1014
G S V+ LDEP+ G+DP +RR +W ++ K RE G+ +++++H ++E + L +A++ G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 1015 RLCCCGSPLFLRRHLGSGYYL 1035
+ C GSP L+ G+ Y L
Sbjct: 121 KFTCLGSPQHLKSKFGNIYIL 141
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 90.9 bits (224), Expect = 1e-17
Identities = 72/244 (29%), Positives = 121/244 (49%), Gaps = 22/244 (9%)
Query: 788 TPLDPKVLVEEAPPGLSPG-VSVRSLEKRFPGSPQ-PALRGLSLDFYQGHITAFLGHNGA 845
TPL E P G V+ + +P P P L+GLSL+ +G A +G +G
Sbjct: 1015 TPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGC 1074
Query: 846 GKTTTLSILSGLFPPSGGSAFILGHDV-RSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWF 904
GK+T + +L + P G + G ++ R ++ +R HLG+ Q +LFD ++ E++ +
Sbjct: 1075 GKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDC-SIAENIAY 1133
Query: 905 YGRLKGLSAAVVGPEQD-RLLQDVG-------LVSKQSVQT----RHLSGGMQRKLSVAI 952
G ++ VV E+ R ++ L +K S + LSGG ++++++A
Sbjct: 1134 -----GDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIAR 1188
Query: 953 AFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVA 1012
A V +++LDE T+ +D S + + E L K REGRT I+ H L + D + V
Sbjct: 1189 ALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQ-NADLIVVFQ 1247
Query: 1013 GGRL 1016
GR+
Sbjct: 1248 NGRV 1251
Score = 89.0 bits (219), Expect = 5e-17
Identities = 101/417 (24%), Positives = 180/417 (43%), Gaps = 40/417 (9%)
Query: 687 VAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGLLLLDAALYGL 746
V A++ + +AFG + L + E A+ + TA++ + LL A Y L
Sbjct: 257 VLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANI----SIGAAFLLIYASYAL 312
Query: 747 ATWY-LEAVCPGQYGIPEPWNFPFR---RSYWCGPRPPKSPAPCPTP---------LDPK 793
A WY V G+Y I + F ++ G P A +D K
Sbjct: 313 AFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNK 372
Query: 794 VLVEE------APPGLSPGVSVRSLEKRFPGSPQ-PALRGLSLDFYQGHITAFLGHNGAG 846
++ P + + R++ +P + L+GL+L G A +G++G G
Sbjct: 373 PSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCG 432
Query: 847 KTTTLSILSGLFPPSGGSAFILGHDVRS-SMAAIRPHLGVCPQYNVLFDMLTVDEHVWFY 905
K+TT+ ++ L+ P+ G + G D+R+ ++ +R +GV Q VLF T+ E++ Y
Sbjct: 433 KSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLF-ATTIAENIR-Y 490
Query: 906 GR----LKGLSAAVVGPEQDRLLQDVG-----LVSKQSVQTRHLSGGMQRKLSVAIAFVG 956
GR + + AV + + LV ++ Q LSGG ++++++A A V
Sbjct: 491 GRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQ---LSGGQKQRIAIARALVR 547
Query: 957 GSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRL 1016
++++LDE T+ +D S + L K R+GRT I+ H L D +A G +
Sbjct: 548 NPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVR-NADVIAGFDDGVI 606
Query: 1017 CCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRV 1073
G+ L + G + L ++ E A + + +D + N S+ S +
Sbjct: 607 VEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLI 663
Score = 57.0 bits (136), Expect = 2e-07
Identities = 52/216 (24%), Positives = 99/216 (45%), Gaps = 15/216 (6%)
Query: 1807 MPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAR---EPS 1863
+P + L L + G+ L+G +G GK++ +++ G+ +L G + R +
Sbjct: 1050 IPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWL 1109
Query: 1864 AAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPA 1923
AHL G Q +F+ E++ R V + ++ + A + ++ +
Sbjct: 1110 RAHL--GIVSQEPILFDCSIA-ENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYS 1166
Query: 1924 ------GTY-SGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGR 1976
GT SGG K+++A A ALV P ++ LDE T+ +D + + + L REGR
Sbjct: 1167 TKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVV-QEALDKAREGR 1225
Query: 1977 SVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHL 2012
+ ++ +H + + + + NGR + G+ Q L
Sbjct: 1226 TCIVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQL 1260
Score = 43.5 bits (101), Expect = 0.002
Identities = 46/181 (25%), Positives = 84/181 (46%), Gaps = 12/181 (6%)
Query: 1813 LCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLS--MG 1870
L L + G+ L+G +G GK++T +++ + G + G + R + L +G
Sbjct: 413 LNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDI-RTINVRFLREIIG 471
Query: 1871 YCPQSDAIF------ELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAG 1924
Q +F + GRE++ + + V EA A L + +R A
Sbjct: 472 VVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEAN-AYDFIMKLPHKFDTLVGERGA- 529
Query: 1925 TYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHS 1984
SGG K+++A A ALV +P ++ LDE T+ +D + + L R+GR+ ++ +H
Sbjct: 530 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV-QVALDKARKGRTTIVIAHR 588
Query: 1985 M 1985
+
Sbjct: 589 L 589
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 85.5 bits (210), Expect = 5e-16
Identities = 64/228 (28%), Positives = 109/228 (47%), Gaps = 9/228 (3%)
Query: 816 FPGSPQP-ALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRS 874
+P P L GLS+ G AF+G +G GK+T++ +L + P G I GHD +
Sbjct: 1087 YPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKK 1146
Query: 875 -SMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQ 933
++ +R ++G+ Q VLF +D + + V+ + L D + +
Sbjct: 1147 VNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPE 1206
Query: 934 SVQTR------HLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYRE 987
+T LS G ++++++A A V ++++LDE T+ +D S + + L K RE
Sbjct: 1207 KYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKARE 1266
Query: 988 GRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYL 1035
GRT I+ H L + D +AV+A G + G+ L G+ Y L
Sbjct: 1267 GRTCIVIAHRLSTIQ-NADIIAVMAQGVVIEKGTHEELMAQKGAYYKL 1313
Score = 78.6 bits (192), Expect = 6e-14
Identities = 53/191 (27%), Positives = 97/191 (50%), Gaps = 10/191 (5%)
Query: 816 FPGSPQ-PALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRS 874
+P P+ L L++ G +TA +G +GAGK+T L ++ + P G + GHD+RS
Sbjct: 429 YPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRS 488
Query: 875 -SMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQ 933
++ +R +G+ Q VLF T+ E++ YGR +V ++ + + Q
Sbjct: 489 LNIQWLRDQIGIVEQEPVLFS-TTIAENI-RYGREDATMEDIVQAAKEANAYNFIMDLPQ 546
Query: 934 SVQT------RHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYRE 987
T +SGG ++++++A A + ++++LD T+ +D S + E+L K +
Sbjct: 547 QFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQH 606
Query: 988 GRTLILSTHHL 998
G T+I H L
Sbjct: 607 GHTIISVAHRL 617
Score = 50.1 bits (118), Expect = 2e-05
Identities = 46/218 (21%), Positives = 98/218 (44%), Gaps = 11/218 (5%)
Query: 1813 LCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAR-EPSAAHLSMGY 1871
L + I PG+ +G +G GK+++ +++ +G+ ++ GH + ++G
Sbjct: 1099 LSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGI 1158
Query: 1872 CPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLAR---LGLSWYADRPAGT--- 1925
Q +F + ++++ + +P +V A + L + G+
Sbjct: 1159 VSQEPVLF-ACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGS 1217
Query: 1926 -YSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHS 1984
S G K+++A A A+V DP ++ LDE T+ +D + + + L REGR+ ++ +H
Sbjct: 1218 QLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV-QVALDKAREGRTCIVIAHR 1276
Query: 1985 MEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTL 2022
+ + +A+M G G+ + L + A + L
Sbjct: 1277 LSTIQN-ADIIAVMAQGVVIEKGTHEELMAQKGAYYKL 1313
Score = 49.7 bits (117), Expect = 3e-05
Identities = 43/184 (23%), Positives = 82/184 (44%), Gaps = 16/184 (8%)
Query: 1817 IPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHL--SMGYCPQ 1874
I PGE L+G +GAGK++ +++ G + GH + R + L +G Q
Sbjct: 445 IKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDI-RSLNIQWLRDQIGIVEQ 503
Query: 1875 SDAIFE------LLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSW--YADRPAGTY 1926
+F + GRE A + + +A A + + L + G
Sbjct: 504 EPVLFSTTIAENIRYGRED----ATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQM 559
Query: 1927 SGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSME 1986
SGG K+++A A AL+ +P ++ LD T+ +D + + +L+ ++ G +++ +H +
Sbjct: 560 SGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMV-QEVLSKIQHGHTIISVAHRLS 618
Query: 1987 ECEA 1990
A
Sbjct: 619 TVRA 622
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 85.5 bits (210), Expect = 5e-16
Identities = 57/203 (28%), Positives = 104/203 (51%), Gaps = 10/203 (4%)
Query: 822 PALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRS-SMAAIR 880
P L+GLSL+ +G A +G +G GK+T + +L + P G+ + G + + ++ +R
Sbjct: 1003 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLR 1062
Query: 881 PHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSA-AVVGPEQDRLLQDVGLVSKQSVQTR- 938
LG+ Q +LFD ++ E++ + + +S +V + + +TR
Sbjct: 1063 AQLGIVSQEPILFDC-SIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRV 1121
Query: 939 -----HLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLIL 993
LSGG ++++++A A + Q+++LDE T+ +D S + + E L K REGRT I+
Sbjct: 1122 GDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIV 1181
Query: 994 STHHLDEAELLGDRVAVVAGGRL 1016
H L + D + V GR+
Sbjct: 1182 IAHRLSTIQ-NADLIVVFQNGRV 1203
Score = 81.6 bits (200), Expect = 7e-15
Identities = 59/185 (31%), Positives = 98/185 (52%), Gaps = 15/185 (8%)
Query: 824 LRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRS-SMAAIRPH 882
L+GL+L G A +G +G GK+TT+ ++ L+ P G+ I G D+R+ ++ +R
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
Query: 883 LGVCPQYNVLFDMLTVDEHVWFYGR----LKGLSAAVVGPEQDRLLQDVG-----LVSKQ 933
+GV Q VLF T+ E++ YGR + + AV + + LV ++
Sbjct: 472 IGVVSQEPVLFST-TIAENIC-YGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGER 529
Query: 934 SVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLIL 993
Q LSGG ++++++A A V ++++LDE T+ +D S + L K REGRT I+
Sbjct: 530 GAQ---LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIV 586
Query: 994 STHHL 998
H L
Sbjct: 587 IAHRL 591
Score = 52.4 bits (124), Expect = 5e-06
Identities = 47/214 (21%), Positives = 92/214 (42%), Gaps = 11/214 (5%)
Query: 1807 MPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAR-EPSAA 1865
+P + L L + G+ L+G +G GK++ +++ G +L G +
Sbjct: 1002 VPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWL 1061
Query: 1866 HLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADR---- 1921
+G Q +F+ E++ R V + ++ A + + +
Sbjct: 1062 RAQLGIVSQEPILFDCSIA-ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETR 1120
Query: 1922 --PAGT-YSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSV 1978
GT SGG K+++A A AL+ P ++ LDE T+ +D + + + L REGR+
Sbjct: 1121 VGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVV-QEALDKAREGRTC 1179
Query: 1979 MLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHL 2012
++ +H + + + + NGR + G+ Q L
Sbjct: 1180 IVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQL 1212
Score = 45.8 bits (107), Expect = 4e-04
Identities = 45/181 (24%), Positives = 85/181 (46%), Gaps = 12/181 (6%)
Query: 1813 LCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLS--MG 1870
L L + G+ L+G +G GK++T +++ G + G + R + +L +G
Sbjct: 415 LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDI-RNFNVNYLREIIG 473
Query: 1871 YCPQSDAIFE------LLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAG 1924
Q +F + GR ++ + + V EA + L + + +R A
Sbjct: 474 VVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMK-LPQKFDTLVGERGA- 531
Query: 1925 TYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHS 1984
SGG K+++A A ALV +P ++ LDE T+ +D + + + L REGR+ ++ +H
Sbjct: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHR 590
Query: 1985 M 1985
+
Sbjct: 591 L 591
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 85.5 bits (210), Expect = 5e-16
Identities = 57/203 (28%), Positives = 104/203 (51%), Gaps = 10/203 (4%)
Query: 822 PALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRS-SMAAIR 880
P L+GLSL+ +G A +G +G GK+T + +L + P G+ + G + + ++ +R
Sbjct: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLR 1109
Query: 881 PHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSA-AVVGPEQDRLLQDVGLVSKQSVQTR- 938
LG+ Q +LFD ++ E++ + + +S +V + + +TR
Sbjct: 1110 AQLGIVSQEPILFDC-SIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRV 1168
Query: 939 -----HLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLIL 993
LSGG ++++++A A + Q+++LDE T+ +D S + + E L K REGRT I+
Sbjct: 1169 GDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIV 1228
Query: 994 STHHLDEAELLGDRVAVVAGGRL 1016
H L + D + V GR+
Sbjct: 1229 IAHRLSTIQ-NADLIVVFQNGRV 1250
Score = 81.6 bits (200), Expect = 7e-15
Identities = 59/185 (31%), Positives = 98/185 (52%), Gaps = 15/185 (8%)
Query: 824 LRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRS-SMAAIRPH 882
L+GL+L G A +G +G GK+TT+ ++ L+ P G+ I G D+R+ ++ +R
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
Query: 883 LGVCPQYNVLFDMLTVDEHVWFYGR----LKGLSAAVVGPEQDRLLQDVG-----LVSKQ 933
+GV Q VLF T+ E++ YGR + + AV + + LV ++
Sbjct: 472 IGVVSQEPVLFST-TIAENIC-YGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGER 529
Query: 934 SVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLIL 993
Q LSGG ++++++A A V ++++LDE T+ +D S + L K REGRT I+
Sbjct: 530 GAQ---LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIV 586
Query: 994 STHHL 998
H L
Sbjct: 587 IAHRL 591
Score = 52.4 bits (124), Expect = 5e-06
Identities = 47/214 (21%), Positives = 92/214 (42%), Gaps = 11/214 (5%)
Query: 1807 MPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAR-EPSAA 1865
+P + L L + G+ L+G +G GK++ +++ G +L G +
Sbjct: 1049 VPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWL 1108
Query: 1866 HLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADR---- 1921
+G Q +F+ E++ R V + ++ A + + +
Sbjct: 1109 RAQLGIVSQEPILFDCSIA-ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETR 1167
Query: 1922 --PAGT-YSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSV 1978
GT SGG K+++A A AL+ P ++ LDE T+ +D + + + L REGR+
Sbjct: 1168 VGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVV-QEALDKAREGRTC 1226
Query: 1979 MLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHL 2012
++ +H + + + + NGR + G+ Q L
Sbjct: 1227 IVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQL 1259
Score = 45.8 bits (107), Expect = 4e-04
Identities = 45/181 (24%), Positives = 85/181 (46%), Gaps = 12/181 (6%)
Query: 1813 LCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLS--MG 1870
L L + G+ L+G +G GK++T +++ G + G + R + +L +G
Sbjct: 415 LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDI-RNFNVNYLREIIG 473
Query: 1871 YCPQSDAIFE------LLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAG 1924
Q +F + GR ++ + + V EA + L + + +R A
Sbjct: 474 VVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMK-LPQKFDTLVGERGA- 531
Query: 1925 TYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHS 1984
SGG K+++A A ALV +P ++ LDE T+ +D + + + L REGR+ ++ +H
Sbjct: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHR 590
Query: 1985 M 1985
+
Sbjct: 591 L 591
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 82.4 bits (202), Expect = 4e-15
Identities = 59/210 (28%), Positives = 103/210 (49%), Gaps = 17/210 (8%)
Query: 822 PALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFI-LGHDVRSSMAA-- 878
P L+GLSL+ +G A +G +G GK+T + +L + P G+ F+ G + A
Sbjct: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKK 1109
Query: 879 -----IRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSA-AVVGPEQDRLLQDVGLVSK 932
+R LG+ Q +LFD ++ E++ + + +S +V + +
Sbjct: 1110 LNVQWLRAQLGIVSQEPILFDC-SIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLP 1168
Query: 933 QSVQTR------HLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYR 986
+TR LSGG ++++++A A + Q+++LDE T+ +D S + + E L K R
Sbjct: 1169 HKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAR 1228
Query: 987 EGRTLILSTHHLDEAELLGDRVAVVAGGRL 1016
EGRT I+ H L + D + V GR+
Sbjct: 1229 EGRTCIVIAHRLSTIQ-NADLIVVFQNGRV 1257
Score = 81.6 bits (200), Expect = 7e-15
Identities = 59/185 (31%), Positives = 98/185 (52%), Gaps = 15/185 (8%)
Query: 824 LRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRS-SMAAIRPH 882
L+GL+L G A +G +G GK+TT+ ++ L+ P G+ I G D+R+ ++ +R
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
Query: 883 LGVCPQYNVLFDMLTVDEHVWFYGR----LKGLSAAVVGPEQDRLLQDVG-----LVSKQ 933
+GV Q VLF T+ E++ YGR + + AV + + LV ++
Sbjct: 472 IGVVSQEPVLFST-TIAENIC-YGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGER 529
Query: 934 SVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLIL 993
Q LSGG ++++++A A V ++++LDE T+ +D S + L K REGRT I+
Sbjct: 530 GAQ---LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIV 586
Query: 994 STHHL 998
H L
Sbjct: 587 IAHRL 591
Score = 51.2 bits (121), Expect = 1e-05
Identities = 48/221 (21%), Positives = 93/221 (42%), Gaps = 18/221 (8%)
Query: 1807 MPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMV-------TGDTLASRGEAVLAGHSVA 1859
+P + L L + G+ L+G +G GK++ +++ G G +L G
Sbjct: 1049 VPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAK 1108
Query: 1860 R-EPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWY 1918
+ +G Q +F+ E++ R V + ++ A + +
Sbjct: 1109 KLNVQWLRAQLGIVSQEPILFDCSIA-ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETL 1167
Query: 1919 ADR------PAGTY-SGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAV 1971
+ GT SGG K+++A A AL+ P ++ LDE T+ +D + + + L
Sbjct: 1168 PHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVV-QEALDK 1226
Query: 1972 VREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHL 2012
REGR+ ++ +H + + + + NGR + G+ Q L
Sbjct: 1227 AREGRTCIVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQL 1266
Score = 45.8 bits (107), Expect = 4e-04
Identities = 45/181 (24%), Positives = 85/181 (46%), Gaps = 12/181 (6%)
Query: 1813 LCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLS--MG 1870
L L + G+ L+G +G GK++T +++ G + G + R + +L +G
Sbjct: 415 LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDI-RNFNVNYLREIIG 473
Query: 1871 YCPQSDAIFE------LLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAG 1924
Q +F + GR ++ + + V EA + L + + +R A
Sbjct: 474 VVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMK-LPQKFDTLVGERGA- 531
Query: 1925 TYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHS 1984
SGG K+++A A ALV +P ++ LDE T+ +D + + + L REGR+ ++ +H
Sbjct: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHR 590
Query: 1985 M 1985
+
Sbjct: 591 L 591
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 81.3 bits (199), Expect = 1e-14
Identities = 66/231 (28%), Positives = 117/231 (50%), Gaps = 22/231 (9%)
Query: 824 LRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRS-SMAAIRPH 882
LRGLSL +G AF+G +G GK+T++ +L L+ P G G D + ++ +R
Sbjct: 588 LRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQ 647
Query: 883 LGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDV--------GLVSKQS 934
+ + PQ VLF+ ++ E++ + G ++ VV ++ + + GL K +
Sbjct: 648 IAIVPQEPVLFNC-SIAENIAY-----GDNSRVVPLDEIKEAANAANIHSFIEGLPEKYN 701
Query: 935 VQT----RHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRT 990
Q LSGG +++L++A A + ++++LDE T+ +D S + + L K R GRT
Sbjct: 702 TQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRT 761
Query: 991 LILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKAR 1041
++ TH L + D + V+ G++ G+ L R+ Y LV A+
Sbjct: 762 CLVVTHRLSAIQ-NADLIVVLHNGKIKEQGTHQELLRN--RDIYFKLVNAQ 809
Score = 55.5 bits (132), Expect = 6e-07
Identities = 56/212 (26%), Positives = 94/212 (44%), Gaps = 32/212 (15%)
Query: 870 HDVRS-SMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVG 928
+D+R+ ++ R H+GV Q VLF T+ ++ YGR V E +R ++
Sbjct: 5 NDIRALNVRHYRDHIGVVSQEPVLFGT-TISNNIK-YGR-----DDVTDEEMERAAREAN 57
Query: 929 --------------LVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPAS 974
LV ++ Q +SGG ++++++A A V +++ILDE T+ +D S
Sbjct: 58 AYDFIMEFPNKFNTLVGEKGAQ---MSGGQKQRIAIARALVRNPKILILDEATSALDSES 114
Query: 975 RRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYY 1034
+ + L K +GRT I+ H L D + + G L G+ L G Y
Sbjct: 115 KSAVQAALEKASKGRTTIVVAHRLSTIR-SADLIVTLKDGMLAEKGAHAELMAKRGLYYS 173
Query: 1035 LTLVKARLPLTTNEKADTDMEGSVDTRQEKKN 1066
L + + +KAD ME + + K N
Sbjct: 174 LVMSQ------DIKKADEQMESMTYSTERKTN 199
Score = 50.4 bits (119), Expect = 2e-05
Identities = 46/209 (22%), Positives = 95/209 (45%), Gaps = 13/209 (6%)
Query: 1813 LCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHL--SMG 1870
L L I G+ +G +G GK+++ +++ +G+ + G A+E + L +
Sbjct: 591 LSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVD-AKELNVQWLRSQIA 649
Query: 1871 YCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADR-------PA 1923
PQ +F E++ R VP ++ + A + + ++
Sbjct: 650 IVPQEPVLFNCSIA-ENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKG 708
Query: 1924 GTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSH 1983
SGG K++LA A AL+ P ++ LDE T+ +D + + + ++ L R GR+ ++ +H
Sbjct: 709 AQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHA-LDKARTGRTCLVVTH 767
Query: 1984 SMEECEALCSRLAIMVNGRFRCLGSPQHL 2012
+ + + ++ NG+ + G+ Q L
Sbjct: 768 RLSAIQN-ADLIVVLHNGKIKEQGTHQEL 795
Score = 40.4 bits (93), Expect = 0.019
Identities = 19/59 (32%), Positives = 37/59 (62%), Gaps = 1/59 (1%)
Query: 1927 SGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSM 1985
SGG K+++A A ALV +P ++ LDE T+ +D ++ + + L +GR+ ++ +H +
Sbjct: 81 SGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV-QAALEKASKGRTTIVVAHRL 138
>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
[Homo sapiens]
Length = 663
Score = 80.9 bits (198), Expect = 1e-14
Identities = 65/227 (28%), Positives = 111/227 (48%), Gaps = 13/227 (5%)
Query: 800 PPGLSPGVSVRSLEKRFPGSP-------QPALRGLSLDFYQGHITAFLGHNGAGKTTTLS 852
P + + R L P P + L+G+S F G + A +G +GAGK+T ++
Sbjct: 67 PRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMN 126
Query: 853 ILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLS 912
IL+G + +G +L + + + R Q ++L LTV E + LK L
Sbjct: 127 ILAG-YRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLK-LQ 184
Query: 913 AAVVGPEQ--DRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGV 970
G + +L +GL+S + +T LSGG +++L++A+ V V+ DEPT+G+
Sbjct: 185 EKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGL 244
Query: 971 DPASRRGIWELLLKYREGRTLILSTHHLDEAEL--LGDRVAVVAGGR 1015
D AS + L+ +G I+ T H A+L L D++ V++ G+
Sbjct: 245 DSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQ 291
Score = 69.7 bits (169), Expect = 3e-11
Identities = 49/165 (29%), Positives = 85/165 (51%), Gaps = 2/165 (1%)
Query: 1820 GECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIF 1879
GE ++G +GAGK++ ++ G AVL + + R+ Y Q D +
Sbjct: 108 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI-NGLPRDLRCFRKVSCYIMQDDMLL 166
Query: 1880 ELLTGREHLELLARLRGVPEAQVA-QTAGSGLARLGLSWYADRPAGTYSGGNKRKLATAL 1938
LT +E + + A L+ + + + L LGL A+ G+ SGG +++LA AL
Sbjct: 167 PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIAL 226
Query: 1939 ALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSH 1983
LV +P V+F DEPT+G+D ++ + + + + + GRS++ T H
Sbjct: 227 ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 271
>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
[Homo sapiens]
Length = 644
Score = 80.9 bits (198), Expect = 1e-14
Identities = 65/227 (28%), Positives = 111/227 (48%), Gaps = 13/227 (5%)
Query: 800 PPGLSPGVSVRSLEKRFPGSP-------QPALRGLSLDFYQGHITAFLGHNGAGKTTTLS 852
P + + R L P P + L+G+S F G + A +G +GAGK+T ++
Sbjct: 48 PRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMN 107
Query: 853 ILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLS 912
IL+G + +G +L + + + R Q ++L LTV E + LK L
Sbjct: 108 ILAG-YRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLK-LQ 165
Query: 913 AAVVGPEQ--DRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGV 970
G + +L +GL+S + +T LSGG +++L++A+ V V+ DEPT+G+
Sbjct: 166 EKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGL 225
Query: 971 DPASRRGIWELLLKYREGRTLILSTHHLDEAEL--LGDRVAVVAGGR 1015
D AS + L+ +G I+ T H A+L L D++ V++ G+
Sbjct: 226 DSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQ 272
Score = 69.7 bits (169), Expect = 3e-11
Identities = 49/165 (29%), Positives = 85/165 (51%), Gaps = 2/165 (1%)
Query: 1820 GECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIF 1879
GE ++G +GAGK++ ++ G AVL + + R+ Y Q D +
Sbjct: 89 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI-NGLPRDLRCFRKVSCYIMQDDMLL 147
Query: 1880 ELLTGREHLELLARLRGVPEAQVA-QTAGSGLARLGLSWYADRPAGTYSGGNKRKLATAL 1938
LT +E + + A L+ + + + L LGL A+ G+ SGG +++LA AL
Sbjct: 148 PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIAL 207
Query: 1939 ALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSH 1983
LV +P V+F DEPT+G+D ++ + + + + + GRS++ T H
Sbjct: 208 ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 252
>gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5
[Homo sapiens]
Length = 668
Score = 80.9 bits (198), Expect = 1e-14
Identities = 65/227 (28%), Positives = 111/227 (48%), Gaps = 13/227 (5%)
Query: 800 PPGLSPGVSVRSLEKRFPGSP-------QPALRGLSLDFYQGHITAFLGHNGAGKTTTLS 852
P + + R L P P + L+G+S F G + A +G +GAGK+T ++
Sbjct: 72 PRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMN 131
Query: 853 ILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLS 912
IL+G + +G +L + + + R Q ++L LTV E + LK L
Sbjct: 132 ILAG-YRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLK-LQ 189
Query: 913 AAVVGPEQ--DRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGV 970
G + +L +GL+S + +T LSGG +++L++A+ V V+ DEPT+G+
Sbjct: 190 EKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGL 249
Query: 971 DPASRRGIWELLLKYREGRTLILSTHHLDEAEL--LGDRVAVVAGGR 1015
D AS + L+ +G I+ T H A+L L D++ V++ G+
Sbjct: 250 DSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQ 296
Score = 69.7 bits (169), Expect = 3e-11
Identities = 49/165 (29%), Positives = 85/165 (51%), Gaps = 2/165 (1%)
Query: 1820 GECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIF 1879
GE ++G +GAGK++ ++ G AVL + + R+ Y Q D +
Sbjct: 113 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI-NGLPRDLRCFRKVSCYIMQDDMLL 171
Query: 1880 ELLTGREHLELLARLRGVPEAQVA-QTAGSGLARLGLSWYADRPAGTYSGGNKRKLATAL 1938
LT +E + + A L+ + + + L LGL A+ G+ SGG +++LA AL
Sbjct: 172 PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIAL 231
Query: 1939 ALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSH 1983
LV +P V+F DEPT+G+D ++ + + + + + GRS++ T H
Sbjct: 232 ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 276
>gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3
[Homo sapiens]
Length = 677
Score = 80.9 bits (198), Expect = 1e-14
Identities = 65/227 (28%), Positives = 111/227 (48%), Gaps = 13/227 (5%)
Query: 800 PPGLSPGVSVRSLEKRFPGSP-------QPALRGLSLDFYQGHITAFLGHNGAGKTTTLS 852
P + + R L P P + L+G+S F G + A +G +GAGK+T ++
Sbjct: 81 PRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMN 140
Query: 853 ILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLS 912
IL+G + +G +L + + + R Q ++L LTV E + LK L
Sbjct: 141 ILAG-YRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLK-LQ 198
Query: 913 AAVVGPEQ--DRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGV 970
G + +L +GL+S + +T LSGG +++L++A+ V V+ DEPT+G+
Sbjct: 199 EKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGL 258
Query: 971 DPASRRGIWELLLKYREGRTLILSTHHLDEAEL--LGDRVAVVAGGR 1015
D AS + L+ +G I+ T H A+L L D++ V++ G+
Sbjct: 259 DSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQ 305
Score = 69.7 bits (169), Expect = 3e-11
Identities = 49/165 (29%), Positives = 85/165 (51%), Gaps = 2/165 (1%)
Query: 1820 GECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIF 1879
GE ++G +GAGK++ ++ G AVL + + R+ Y Q D +
Sbjct: 122 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI-NGLPRDLRCFRKVSCYIMQDDMLL 180
Query: 1880 ELLTGREHLELLARLRGVPEAQVA-QTAGSGLARLGLSWYADRPAGTYSGGNKRKLATAL 1938
LT +E + + A L+ + + + L LGL A+ G+ SGG +++LA AL
Sbjct: 181 PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIAL 240
Query: 1939 ALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSH 1983
LV +P V+F DEPT+G+D ++ + + + + + GRS++ T H
Sbjct: 241 ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 285
>gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4
[Homo sapiens]
Length = 678
Score = 80.9 bits (198), Expect = 1e-14
Identities = 65/227 (28%), Positives = 111/227 (48%), Gaps = 13/227 (5%)
Query: 800 PPGLSPGVSVRSLEKRFPGSP-------QPALRGLSLDFYQGHITAFLGHNGAGKTTTLS 852
P + + R L P P + L+G+S F G + A +G +GAGK+T ++
Sbjct: 70 PRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMN 129
Query: 853 ILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLS 912
IL+G + +G +L + + + R Q ++L LTV E + LK L
Sbjct: 130 ILAG-YRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLK-LQ 187
Query: 913 AAVVGPEQ--DRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGV 970
G + +L +GL+S + +T LSGG +++L++A+ V V+ DEPT+G+
Sbjct: 188 EKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGL 247
Query: 971 DPASRRGIWELLLKYREGRTLILSTHHLDEAEL--LGDRVAVVAGGR 1015
D AS + L+ +G I+ T H A+L L D++ V++ G+
Sbjct: 248 DSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQ 294
Score = 69.7 bits (169), Expect = 3e-11
Identities = 49/165 (29%), Positives = 85/165 (51%), Gaps = 2/165 (1%)
Query: 1820 GECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIF 1879
GE ++G +GAGK++ ++ G AVL + + R+ Y Q D +
Sbjct: 111 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI-NGLPRDLRCFRKVSCYIMQDDMLL 169
Query: 1880 ELLTGREHLELLARLRGVPEAQVA-QTAGSGLARLGLSWYADRPAGTYSGGNKRKLATAL 1938
LT +E + + A L+ + + + L LGL A+ G+ SGG +++LA AL
Sbjct: 170 PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIAL 229
Query: 1939 ALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSH 1983
LV +P V+F DEPT+G+D ++ + + + + + GRS++ T H
Sbjct: 230 ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 274
>gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2
[Homo sapiens]
Length = 666
Score = 80.9 bits (198), Expect = 1e-14
Identities = 65/227 (28%), Positives = 111/227 (48%), Gaps = 13/227 (5%)
Query: 800 PPGLSPGVSVRSLEKRFPGSP-------QPALRGLSLDFYQGHITAFLGHNGAGKTTTLS 852
P + + R L P P + L+G+S F G + A +G +GAGK+T ++
Sbjct: 70 PRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMN 129
Query: 853 ILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLS 912
IL+G + +G +L + + + R Q ++L LTV E + LK L
Sbjct: 130 ILAG-YRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLK-LQ 187
Query: 913 AAVVGPEQ--DRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGV 970
G + +L +GL+S + +T LSGG +++L++A+ V V+ DEPT+G+
Sbjct: 188 EKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGL 247
Query: 971 DPASRRGIWELLLKYREGRTLILSTHHLDEAEL--LGDRVAVVAGGR 1015
D AS + L+ +G I+ T H A+L L D++ V++ G+
Sbjct: 248 DSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQ 294
Score = 69.7 bits (169), Expect = 3e-11
Identities = 49/165 (29%), Positives = 85/165 (51%), Gaps = 2/165 (1%)
Query: 1820 GECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIF 1879
GE ++G +GAGK++ ++ G AVL + + R+ Y Q D +
Sbjct: 111 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI-NGLPRDLRCFRKVSCYIMQDDMLL 169
Query: 1880 ELLTGREHLELLARLRGVPEAQVA-QTAGSGLARLGLSWYADRPAGTYSGGNKRKLATAL 1938
LT +E + + A L+ + + + L LGL A+ G+ SGG +++LA AL
Sbjct: 170 PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIAL 229
Query: 1939 ALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSH 1983
LV +P V+F DEPT+G+D ++ + + + + + GRS++ T H
Sbjct: 230 ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 274
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,351,888
Number of Sequences: 37866
Number of extensions: 4633458
Number of successful extensions: 16619
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 86
Number of HSP's successfully gapped in prelim test: 48
Number of HSP's that attempted gapping in prelim test: 15722
Number of HSP's gapped (non-prelim): 590
length of query: 2146
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2028
effective length of database: 13,779,330
effective search space: 27944481240
effective search space used: 27944481240
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.