Search of human proteins with 150378489

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|150378489 G protein-coupled receptor associated sorting
protein 1 [Homo sapiens]
         (1395 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|150378528 G protein-coupled receptor associated sorting prote...  2846   0.0  
gi|150378489 G protein-coupled receptor associated sorting prote...  2846   0.0  
gi|103472136 G protein-coupled receptor associated sorting prote...  2846   0.0  
gi|51702248 G protein-coupled receptor associated sorting protei...   631   e-180
gi|19923967 G protein-coupled receptor associated sorting protei...   631   e-180
gi|239757861 PREDICTED: similar to armadillo repeat containing, ...   257   6e-68
gi|216547715 basic helix-loop-helix domain containing, class B, ...   236   1e-61
gi|216547682 basic helix-loop-helix domain containing, class B, ...   236   1e-61
gi|216547672 basic helix-loop-helix domain containing, class B, ...   236   1e-61
gi|216547663 basic helix-loop-helix domain containing, class B, ...   236   1e-61
gi|216547655 basic helix-loop-helix domain containing, class B, ...   236   1e-61
gi|216547646 basic helix-loop-helix domain containing, class B, ...   236   1e-61
gi|216547639 basic helix-loop-helix domain containing, class B, ...   236   1e-61
gi|39930463 basic helix-loop-helix domain containing, class B, 9...   236   1e-61
gi|41054846 armadillo repeat containing, X-linked 5 [Homo sapiens]    197   8e-50
gi|29540566 armadillo repeat containing, X-linked 3 [Homo sapiens]    137   7e-32
gi|29540564 armadillo repeat containing, X-linked 3 [Homo sapiens]    137   7e-32
gi|7705274 armadillo repeat containing, X-linked 3 [Homo sapiens]     137   7e-32
gi|7706143 armadillo repeat containing, X-linked 1 [Homo sapiens]     134   5e-31
gi|238776793 SVH protein isoform b [Homo sapiens]                     120   7e-27
gi|31377663 SVH protein isoform a [Homo sapiens]                      120   7e-27
gi|7662162 ALEX2 protein [Homo sapiens]                               111   6e-24
gi|29540562 ALEX2 protein [Homo sapiens]                              111   6e-24
gi|169165522 PREDICTED: similar to SVH protein isoform 1 [Homo s...    86   3e-16
gi|169165931 PREDICTED: similar to SVH protein isoform 1 [Homo s...    84   1e-15
gi|113414573 PREDICTED: similar to SVH protein isoform 2 [Homo s...    84   1e-15
gi|238776797 SVH protein isoform e [Homo sapiens]                      83   2e-15
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    54   1e-06
gi|169165524 PREDICTED: similar to SVH protein isoform 2 [Homo s...    52   3e-06
gi|238776799 SVH protein isoform d [Homo sapiens]                      52   5e-06

>gi|150378528 G protein-coupled receptor associated sorting protein 1
            [Homo sapiens]
          Length = 1395

 Score = 2846 bits (7378), Expect = 0.0
 Identities = 1395/1395 (100%), Positives = 1395/1395 (100%)

Query: 1    MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 60
            MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP
Sbjct: 1    MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 60

Query: 61   GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 120
            GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP
Sbjct: 61   GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 120

Query: 121  LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP 180
            LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP
Sbjct: 121  LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP 180

Query: 181  TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ 240
            TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ
Sbjct: 181  TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ 240

Query: 241  TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE 300
            TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE
Sbjct: 241  TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE 300

Query: 301  HEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE 360
            HEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE
Sbjct: 301  HEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE 360

Query: 361  ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE 420
            ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE
Sbjct: 361  ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE 420

Query: 421  ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG 480
            ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG
Sbjct: 421  ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG 480

Query: 481  AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES 540
            AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES
Sbjct: 481  AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES 540

Query: 541  RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC 600
            RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC
Sbjct: 541  RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC 600

Query: 601  DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV 660
            DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV
Sbjct: 601  DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV 660

Query: 661  RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII 720
            RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII
Sbjct: 661  RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII 720

Query: 721  GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG 780
            GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG
Sbjct: 721  GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG 780

Query: 781  SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE 840
            SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE
Sbjct: 781  SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE 840

Query: 841  VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE 900
            VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE
Sbjct: 841  VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE 900

Query: 901  TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK 960
            TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK
Sbjct: 901  TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK 960

Query: 961  PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP 1020
            PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP
Sbjct: 961  PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP 1020

Query: 1021 VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE 1080
            VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE
Sbjct: 1021 VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE 1080

Query: 1081 MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS 1140
            MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS
Sbjct: 1081 MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS 1140

Query: 1141 SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL 1200
            SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL
Sbjct: 1141 SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL 1200

Query: 1201 IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1260
            IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM
Sbjct: 1201 IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1260

Query: 1261 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1320
            IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS
Sbjct: 1261 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1320

Query: 1321 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ 1380
            EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ
Sbjct: 1321 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ 1380

Query: 1381 GKTDNQNDPEGDQEN 1395
            GKTDNQNDPEGDQEN
Sbjct: 1381 GKTDNQNDPEGDQEN 1395


>gi|150378489 G protein-coupled receptor associated sorting protein 1
            [Homo sapiens]
          Length = 1395

 Score = 2846 bits (7378), Expect = 0.0
 Identities = 1395/1395 (100%), Positives = 1395/1395 (100%)

Query: 1    MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 60
            MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP
Sbjct: 1    MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 60

Query: 61   GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 120
            GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP
Sbjct: 61   GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 120

Query: 121  LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP 180
            LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP
Sbjct: 121  LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP 180

Query: 181  TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ 240
            TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ
Sbjct: 181  TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ 240

Query: 241  TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE 300
            TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE
Sbjct: 241  TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE 300

Query: 301  HEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE 360
            HEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE
Sbjct: 301  HEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE 360

Query: 361  ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE 420
            ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE
Sbjct: 361  ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE 420

Query: 421  ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG 480
            ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG
Sbjct: 421  ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG 480

Query: 481  AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES 540
            AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES
Sbjct: 481  AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES 540

Query: 541  RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC 600
            RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC
Sbjct: 541  RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC 600

Query: 601  DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV 660
            DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV
Sbjct: 601  DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV 660

Query: 661  RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII 720
            RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII
Sbjct: 661  RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII 720

Query: 721  GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG 780
            GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG
Sbjct: 721  GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG 780

Query: 781  SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE 840
            SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE
Sbjct: 781  SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE 840

Query: 841  VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE 900
            VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE
Sbjct: 841  VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE 900

Query: 901  TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK 960
            TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK
Sbjct: 901  TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK 960

Query: 961  PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP 1020
            PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP
Sbjct: 961  PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP 1020

Query: 1021 VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE 1080
            VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE
Sbjct: 1021 VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE 1080

Query: 1081 MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS 1140
            MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS
Sbjct: 1081 MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS 1140

Query: 1141 SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL 1200
            SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL
Sbjct: 1141 SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL 1200

Query: 1201 IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1260
            IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM
Sbjct: 1201 IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1260

Query: 1261 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1320
            IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS
Sbjct: 1261 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1320

Query: 1321 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ 1380
            EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ
Sbjct: 1321 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ 1380

Query: 1381 GKTDNQNDPEGDQEN 1395
            GKTDNQNDPEGDQEN
Sbjct: 1381 GKTDNQNDPEGDQEN 1395


>gi|103472136 G protein-coupled receptor associated sorting protein 1
            [Homo sapiens]
          Length = 1395

 Score = 2846 bits (7378), Expect = 0.0
 Identities = 1395/1395 (100%), Positives = 1395/1395 (100%)

Query: 1    MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 60
            MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP
Sbjct: 1    MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 60

Query: 61   GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 120
            GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP
Sbjct: 61   GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 120

Query: 121  LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP 180
            LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP
Sbjct: 121  LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP 180

Query: 181  TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ 240
            TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ
Sbjct: 181  TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ 240

Query: 241  TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE 300
            TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE
Sbjct: 241  TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE 300

Query: 301  HEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE 360
            HEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE
Sbjct: 301  HEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE 360

Query: 361  ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE 420
            ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE
Sbjct: 361  ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE 420

Query: 421  ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG 480
            ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG
Sbjct: 421  ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG 480

Query: 481  AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES 540
            AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES
Sbjct: 481  AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES 540

Query: 541  RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC 600
            RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC
Sbjct: 541  RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC 600

Query: 601  DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV 660
            DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV
Sbjct: 601  DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV 660

Query: 661  RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII 720
            RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII
Sbjct: 661  RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII 720

Query: 721  GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG 780
            GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG
Sbjct: 721  GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG 780

Query: 781  SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE 840
            SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE
Sbjct: 781  SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE 840

Query: 841  VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE 900
            VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE
Sbjct: 841  VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE 900

Query: 901  TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK 960
            TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK
Sbjct: 901  TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK 960

Query: 961  PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP 1020
            PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP
Sbjct: 961  PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP 1020

Query: 1021 VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE 1080
            VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE
Sbjct: 1021 VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE 1080

Query: 1081 MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS 1140
            MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS
Sbjct: 1081 MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS 1140

Query: 1141 SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL 1200
            SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL
Sbjct: 1141 SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL 1200

Query: 1201 IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1260
            IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM
Sbjct: 1201 IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1260

Query: 1261 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1320
            IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS
Sbjct: 1261 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1320

Query: 1321 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ 1380
            EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ
Sbjct: 1321 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ 1380

Query: 1381 GKTDNQNDPEGDQEN 1395
            GKTDNQNDPEGDQEN
Sbjct: 1381 GKTDNQNDPEGDQEN 1395


>gi|51702248 G protein-coupled receptor associated sorting protein 2
            [Homo sapiens]
          Length = 838

 Score =  631 bits (1627), Expect = e-180
 Identities = 367/702 (52%), Positives = 452/702 (64%), Gaps = 69/702 (9%)

Query: 700  EEDIVNSWFWSRKYTKPEAIIGSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEA 759
            EE  + SW +SR   + EA   S  W+ +E     T   +   T EET + SW  +E   
Sbjct: 200  EETNMGSWCYSRPRAREEASNESGFWSADE-----TSTASSFWTGEETSVRSWPREESNT 254

Query: 760  ISEATDREE----SRPEAEEGDIIGSWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWF 815
             S    + +    SRP +++   + SW  +G ED                E       W 
Sbjct: 255  RSRHRAKHQTNPRSRPRSKQEAYVDSW--SGSED----------------EASNPFSFWV 296

Query: 816  GAREETIRREAGSCSKSSPKAEEEEVIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITV 875
            G     + R         P+  EE  I        E          FES+    E+E   
Sbjct: 297  GENTNNLFR---------PRVREEANIRSKLRTNREDC--------FESE---SEDEFYK 336

Query: 876  GSWFWPEEEASIQAGSQAVEEMESETEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEM 935
             SW  P EEA+ +   +  E+  +  +   +      D   V +E        P  +EE+
Sbjct: 337  QSWVLPGEEANSRFRHRDKEDPNTALK---LRAQKDVDSDRVKQE--------PRFEEEV 385

Query: 936  IVESWFWSRDKAIKETGTVATCESKPENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLA 995
            I+ SWFW+  +A  E G  A CES+P  EEGAI GS + AE+    ++  G+        
Sbjct: 386  IIGSWFWAEKEASLEGGASAICESEPGTEEGAIGGSAYWAEE----KSSLGAVAREEAKP 441

Query: 996  D-EDEAIVGSWFWAGDEAHFESNPSPVFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKP 1054
            + E+EAI GSWFW  DEA F+ NP PV++   R   + E E + S RPQ+W+EVTV+FKP
Sbjct: 442  ESEEEAIFGSWFWDRDEACFDLNPCPVYKVSDRFRDAAE-ELNASSRPQTWDEVTVEFKP 500

Query: 1055 GPWGRVGFPSISPFRFPKEAASLFCEMFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQ 1114
            G +  VGF S SPF  P+EA+    EM   KP+N+ LSPEGE+QESLLQPDQPSPEF FQ
Sbjct: 501  GLFHGVGFRSTSPFGIPEEAS----EMLEAKPKNLELSPEGEEQESLLQPDQPSPEFTFQ 556

Query: 1115 YDPSYRSVQEIREHLRAKESTEPESSSCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEI 1174
            YDPSYRSV+EIREHLRA+ES E ES SC+CIQCELKIGSEEFEE LLLM+KIRDPFIHEI
Sbjct: 557  YDPSYRSVREIREHLRARESAESESWSCSCIQCELKIGSEEFEEFLLLMDKIRDPFIHEI 616

Query: 1175 SKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQ 1234
            SKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMI MAPPYPNLN+I+
Sbjct: 617  SKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIHMAPPYPNLNMIE 676

Query: 1235 TYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRF 1294
            T+IC+VCEETLA+SVDS EQL+GIRM+RHLT T DYHTL+ANYMSGFLSLL T NA+T+F
Sbjct: 677  TFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGFLSLLTTANARTKF 736

Query: 1295 HVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREETNDNIQIVLAIFENIGNNIKK-ET 1353
            HVLKMLLNLSEN  + K+L SA+A+S F+GLFN EETNDNIQIV+ +F+NI N IK  + 
Sbjct: 737  HVLKMLLNLSENPAVAKKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIIKSGKM 796

Query: 1354 VFSDDDFNIEPLISAFHKVEKFAKELQGKTDNQNDPEGDQEN 1395
               DDDF++EPLISAF + E+ AK+LQ + DNQNDPE  Q++
Sbjct: 797  SLIDDDFSLEPLISAFREFEELAKQLQAQIDNQNDPEVGQQS 838



 Score =  319 bits (818), Expect = 1e-86
 Identities = 210/513 (40%), Positives = 273/513 (53%), Gaps = 94/513 (18%)

Query: 1   MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQA---------------- 44
           MTGAEIE  AQ KPEKK GEEV+ G E ENDVPLVVRPKVRTQA                
Sbjct: 1   MTGAEIEPSAQAKPEKKAGEEVIAGPERENDVPLVVRPKVRTQATTGARPKTETKSVPAA 60

Query: 45  ------------------QIMPGARPKNKSKVMPGASTKVETSAVGGARPKSKAKAIPVS 86
                             Q+M GARPK +++ + GA  K +  AVGGAR K+ AKAIP +
Sbjct: 61  RPKTEAQAMSGARPKTEVQVMGGARPKTEAQGITGARPKTDARAVGGARSKTDAKAIPGA 120

Query: 87  RFKEEAQMWAQPRFGAERLSKTERNSQTNIIASPLVSTDSVLVAKTKYLSEDRELVNTDT 146
           R K+EAQ WAQ  FG E +S+ E  SQTN +A PL + +S  V K+K LS DRELVN D 
Sbjct: 121 RPKDEAQAWAQSEFGTEAVSQAEGVSQTNAVAWPLATAESGSVTKSKGLSMDRELVNVDA 180

Query: 147 ESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRPTSKQEASPNSDFKWVDK-SVSSLFWS 205
           E+FP  +   Q G QP F   EETNMGSWC  RP +++EAS  S F   D+ S +S FW+
Sbjct: 181 ETFPGTQG--QKGIQPWFGPGEETNMGSWCYSRPRAREEASNESGFWSADETSTASSFWT 238

Query: 206 GDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQTNQELYIASSSGSEDESVKTPWFWA 265
           G+E + +  P  R + + RS H A  + N  SR ++ QE Y+ S SGSEDE+     FW 
Sbjct: 239 GEETSVRSWP--REESNTRSRHRAKHQTNPRSRPRSKQEAYVDSWSGSEDEASNPFSFWV 296

Query: 266 RDKTNTWSGP--REDPNSRSRFRSKKEVYVESSSGSEHEDHLESWFGAGKEAKFRSKMRA 323
            + TN    P  RE+ N RS+ R+ +E   ES   SE E + +SW            +  
Sbjct: 297 GENTNNLFRPRVREEANIRSKLRTNREDCFESE--SEDEFYKQSW------------VLP 342

Query: 324 GKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPEENANTFSRPMIKKEARARAMTKE 383
           G+EAN+R RHR K                        E+ NT             A+   
Sbjct: 343 GEEANSRFRHRDK------------------------EDPNT-------------ALKLR 365

Query: 384 EAKTKARARAKQEARSEEEALIGTWFWATDESSMADEAS--IESSLQVEDESIIGSWFWT 441
             K     R KQE R EEE +IG+WFWA  E+S+   AS   ES    E+ +I GS +W 
Sbjct: 366 AQKDVDSDRVKQEPRFEEEVIIGSWFWAEKEASLEGGASAICESEPGTEEGAIGGSAYWA 425

Query: 442 EEEASMGTGASSKSRPRTDGERIGDSLFGAREK 474
           EE++S+G  A  +++P ++ E I  S F  R++
Sbjct: 426 EEKSSLGAVAREEAKPESEEEAIFGSWFWDRDE 458



 Score =  144 bits (364), Expect = 5e-34
 Identities = 145/553 (26%), Positives = 218/553 (39%), Gaps = 104/553 (18%)

Query: 86  SRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASPLVSTDSVLVAKTKYLSEDRELVNTD 145
           +  +  AQ   + + G E ++  ER +   ++  P V T +   A+ K          T+
Sbjct: 4   AEIEPSAQAKPEKKAGEEVIAGPERENDVPLVVRPKVRTQATTGARPK----------TE 53

Query: 146 TESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRPTSK--QEASPNSDFKWVDKSVSSLF 203
           T+S P  +   +A      R K E  +     P+  ++    A P +D + V  + S   
Sbjct: 54  TKSVPAARPKTEAQAMSGARPKTEVQVMGGARPKTEAQGITGARPKTDARAVGGARS--- 110

Query: 204 WSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQTNQELYIASSSGSEDESVKTPWF 263
               +  AK  PG R KD          EA   ++S+   E    +   S+  +V  P  
Sbjct: 111 ----KTDAKAIPGARPKD----------EAQAWAQSEFGTEAVSQAEGVSQTNAVAWPLA 156

Query: 264 WARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSEHEDHLESWFGAGKEAKFRSKMRA 323
            A       SG        S  R    V  E+  G++ +  ++ WFG G+E    S   +
Sbjct: 157 TAE------SGSVTKSKGLSMDRELVNVDAETFPGTQGQKGIQPWFGPGEETNMGSWCYS 210

Query: 324 GKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPEENANTFSRPMIKKEARARAMTKE 383
                   R RA+ EA  +    S D     S FW  E  +  S P  +   R+R   K 
Sbjct: 211 --------RPRAREEASNESGFWSADETSTASSFWTGEETSVRSWPREESNTRSRHRAKH 262

Query: 384 EAKTKARARAKQEAR------SEEEALIGTWFWATDESS------MADEASIESSLQV-- 429
           +   ++R R+KQEA       SE+EA     FW  + ++      + +EA+I S L+   
Sbjct: 263 QTNPRSRPRSKQEAYVDSWSGSEDEASNPFSFWVGENTNNLFRPRVREEANIRSKLRTNR 322

Query: 430 --------EDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTGA 481
                   EDE    SW    EEA+                    S F  R+K    T  
Sbjct: 323 EDCFESESEDEFYKQSWVLPGEEAN--------------------SRFRHRDKEDPNTAL 362

Query: 482 EATSESILAADDEQVIIGSWFWAGEEVNQEA--EEETIFGSWFWVIDAASVESGVGVSCE 539
           +  ++  + +D               V QE   EEE I GSWFW    AS+E G    CE
Sbjct: 363 KLRAQKDVDSD--------------RVKQEPRFEEEVIIGSWFWAEKEASLEGGASAICE 408

Query: 540 SRTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMD---CRA 596
           S   +EE  + G  +W+ E+  + A   EEA+P +EEE IFGSWFW  ++   D   C  
Sbjct: 409 SEPGTEEGAIGGSAYWAEEKSSLGAVAREEAKPESEEEAIFGSWFWDRDEACFDLNPCPV 468

Query: 597 ETSCDTMQGAEEE 609
               D  + A EE
Sbjct: 469 YKVSDRFRDAAEE 481



 Score =  104 bits (259), Expect = 7e-22
 Identities = 128/499 (25%), Positives = 197/499 (39%), Gaps = 113/499 (22%)

Query: 368 RPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADEASIESSL 427
           RP ++ +A   A  K E K+   AR K EA++   A   T                    
Sbjct: 37  RPKVRTQATTGARPKTETKSVPAARPKTEAQAMSGARPKT-------------------- 76

Query: 428 QVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKT--GAEATS 485
             E + + G+   TE +   G      +RP+TD   +G    GAR KT  K   GA    
Sbjct: 77  --EVQVMGGARPKTEAQGITG------ARPKTDARAVG----GARSKTDAKAIPGARPKD 124

Query: 486 ESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESG------------ 533
           E+   A  E          G E   +AE  +   +  W +  A+ ESG            
Sbjct: 125 EAQAWAQSE---------FGTEAVSQAEGVSQTNAVAWPL--ATAESGSVTKSKGLSMDR 173

Query: 534 --VGVSCESRTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTY 591
             V V  E+   ++ ++ I PWF  GE+ ++  G    +RP A EE    S FW+ ++T 
Sbjct: 174 ELVNVDAETFPGTQGQKGIQPWFGPGEETNM--GSWCYSRPRAREEASNESGFWSADET- 230

Query: 592 MDCRAETSCDTMQGAEEEEPIIGSW----FWTRVEACVEGDVNSKSSLEDKEEAMIPCFG 647
                 T+     G   EE  + SW      TR     +   N +S    K+EA +  + 
Sbjct: 231 -----STASSFWTG---EETSVRSWPREESNTRSRHRAKHQTNPRSRPRSKQEAYVDSWS 282

Query: 648 AKEE-----VSMKHGTGVRCRFMAGAEE---------TNNKSCFWAEKEPCMYPAG---- 689
             E+      S   G      F     E         TN + CF +E E   Y       
Sbjct: 283 GSEDEASNPFSFWVGENTNNLFRPRVREEANIRSKLRTNREDCFESESEDEFYKQSWVLP 342

Query: 690 ----GGSWKSRPEEE----------EDIVNSWFWSRKYTKPEAIIGSWLWATEESNIDGT 735
                  ++ R +E+          +D+ +         + E IIGSW WA +E++++G 
Sbjct: 343 GEEANSRFRHRDKEDPNTALKLRAQKDVDSDRVKQEPRFEEEVIIGSWFWAEKEASLEGG 402

Query: 736 GE---KAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIGSWFWAGEEDRLE 792
                +++  TEE  I  S +W E+++   A  REE++PE+EE  I GSWFW  +E   +
Sbjct: 403 ASAICESEPGTEEGAIGGSAYWAEEKSSLGAVAREEAKPESEEEAIFGSWFWDRDEACFD 462

Query: 793 ----PAAETREEDRLAAEK 807
               P  +  +  R AAE+
Sbjct: 463 LNPCPVYKVSDRFRDAAEE 481



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 80/291 (27%), Positives = 115/291 (39%), Gaps = 47/291 (16%)

Query: 802  RLAAEKEGIVGSWFGAREETIRREAGSC-SKSSPKAEEEEVIIGSWFWEEEASPEAVAGV 860
            R   E +GI G    AR +T  R  G   SK+  KA      I     ++EA   A +  
Sbjct: 85   RPKTEAQGITG----ARPKTDARAVGGARSKTDAKA------IPGARPKDEAQAWAQSEF 134

Query: 861  GFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEE---MESE---TEEETIFGS----- 909
            G E+    E    T  +  WP   A+ ++GS    +   M+ E    + ET  G+     
Sbjct: 135  GTEAVSQAEGVSQT-NAVAWPL--ATAESGSVTKSKGLSMDRELVNVDAETFPGTQGQKG 191

Query: 910  ---WFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESKPENEEG 966
               WF  G+E +   G  C S+P   EE   ES FWS D    ET T ++  +  E    
Sbjct: 192  IQPWFGPGEETN--MGSWCYSRPRAREEASNESGFWSAD----ETSTASSFWTGEETS-- 243

Query: 967  AIVGSW--FEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAH------FESNP 1018
              V SW   E+     +R  + +N  SR    + EA V SW  + DEA          N 
Sbjct: 244  --VRSWPREESNTRSRHRAKHQTNPRSRP-RSKQEAYVDSWSGSEDEASNPFSFWVGENT 300

Query: 1019 SPVFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFR 1069
            + +FR   R   ++  +   +R      E   +F    W   G  + S FR
Sbjct: 301  NNLFRPRVREEANIRSKLRTNREDCFESESEDEFYKQSWVLPGEEANSRFR 351


>gi|19923967 G protein-coupled receptor associated sorting protein 2
            [Homo sapiens]
          Length = 838

 Score =  631 bits (1627), Expect = e-180
 Identities = 367/702 (52%), Positives = 452/702 (64%), Gaps = 69/702 (9%)

Query: 700  EEDIVNSWFWSRKYTKPEAIIGSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEA 759
            EE  + SW +SR   + EA   S  W+ +E     T   +   T EET + SW  +E   
Sbjct: 200  EETNMGSWCYSRPRAREEASNESGFWSADE-----TSTASSFWTGEETSVRSWPREESNT 254

Query: 760  ISEATDREE----SRPEAEEGDIIGSWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWF 815
             S    + +    SRP +++   + SW  +G ED                E       W 
Sbjct: 255  RSRHRAKHQTNPRSRPRSKQEAYVDSW--SGSED----------------EASNPFSFWV 296

Query: 816  GAREETIRREAGSCSKSSPKAEEEEVIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITV 875
            G     + R         P+  EE  I        E          FES+    E+E   
Sbjct: 297  GENTNNLFR---------PRVREEANIRSKLRTNREDC--------FESE---SEDEFYK 336

Query: 876  GSWFWPEEEASIQAGSQAVEEMESETEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEM 935
             SW  P EEA+ +   +  E+  +  +   +      D   V +E        P  +EE+
Sbjct: 337  QSWVLPGEEANSRFRHRDKEDPNTALK---LRAQKDVDSDRVKQE--------PRFEEEV 385

Query: 936  IVESWFWSRDKAIKETGTVATCESKPENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLA 995
            I+ SWFW+  +A  E G  A CES+P  EEGAI GS + AE+    ++  G+        
Sbjct: 386  IIGSWFWAEKEASLEGGASAICESEPGTEEGAIGGSAYWAEE----KSSLGAVAREEAKP 441

Query: 996  D-EDEAIVGSWFWAGDEAHFESNPSPVFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKP 1054
            + E+EAI GSWFW  DEA F+ NP PV++   R   + E E + S RPQ+W+EVTV+FKP
Sbjct: 442  ESEEEAIFGSWFWDRDEACFDLNPCPVYKVSDRFRDAAE-ELNASSRPQTWDEVTVEFKP 500

Query: 1055 GPWGRVGFPSISPFRFPKEAASLFCEMFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQ 1114
            G +  VGF S SPF  P+EA+    EM   KP+N+ LSPEGE+QESLLQPDQPSPEF FQ
Sbjct: 501  GLFHGVGFRSTSPFGIPEEAS----EMLEAKPKNLELSPEGEEQESLLQPDQPSPEFTFQ 556

Query: 1115 YDPSYRSVQEIREHLRAKESTEPESSSCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEI 1174
            YDPSYRSV+EIREHLRA+ES E ES SC+CIQCELKIGSEEFEE LLLM+KIRDPFIHEI
Sbjct: 557  YDPSYRSVREIREHLRARESAESESWSCSCIQCELKIGSEEFEEFLLLMDKIRDPFIHEI 616

Query: 1175 SKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQ 1234
            SKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMI MAPPYPNLN+I+
Sbjct: 617  SKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIHMAPPYPNLNMIE 676

Query: 1235 TYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRF 1294
            T+IC+VCEETLA+SVDS EQL+GIRM+RHLT T DYHTL+ANYMSGFLSLL T NA+T+F
Sbjct: 677  TFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGFLSLLTTANARTKF 736

Query: 1295 HVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREETNDNIQIVLAIFENIGNNIKK-ET 1353
            HVLKMLLNLSEN  + K+L SA+A+S F+GLFN EETNDNIQIV+ +F+NI N IK  + 
Sbjct: 737  HVLKMLLNLSENPAVAKKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIIKSGKM 796

Query: 1354 VFSDDDFNIEPLISAFHKVEKFAKELQGKTDNQNDPEGDQEN 1395
               DDDF++EPLISAF + E+ AK+LQ + DNQNDPE  Q++
Sbjct: 797  SLIDDDFSLEPLISAFREFEELAKQLQAQIDNQNDPEVGQQS 838



 Score =  319 bits (818), Expect = 1e-86
 Identities = 210/513 (40%), Positives = 273/513 (53%), Gaps = 94/513 (18%)

Query: 1   MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQA---------------- 44
           MTGAEIE  AQ KPEKK GEEV+ G E ENDVPLVVRPKVRTQA                
Sbjct: 1   MTGAEIEPSAQAKPEKKAGEEVIAGPERENDVPLVVRPKVRTQATTGARPKTETKSVPAA 60

Query: 45  ------------------QIMPGARPKNKSKVMPGASTKVETSAVGGARPKSKAKAIPVS 86
                             Q+M GARPK +++ + GA  K +  AVGGAR K+ AKAIP +
Sbjct: 61  RPKTEAQAMSGARPKTEVQVMGGARPKTEAQGITGARPKTDARAVGGARSKTDAKAIPGA 120

Query: 87  RFKEEAQMWAQPRFGAERLSKTERNSQTNIIASPLVSTDSVLVAKTKYLSEDRELVNTDT 146
           R K+EAQ WAQ  FG E +S+ E  SQTN +A PL + +S  V K+K LS DRELVN D 
Sbjct: 121 RPKDEAQAWAQSEFGTEAVSQAEGVSQTNAVAWPLATAESGSVTKSKGLSMDRELVNVDA 180

Query: 147 ESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRPTSKQEASPNSDFKWVDK-SVSSLFWS 205
           E+FP  +   Q G QP F   EETNMGSWC  RP +++EAS  S F   D+ S +S FW+
Sbjct: 181 ETFPGTQG--QKGIQPWFGPGEETNMGSWCYSRPRAREEASNESGFWSADETSTASSFWT 238

Query: 206 GDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQTNQELYIASSSGSEDESVKTPWFWA 265
           G+E + +  P  R + + RS H A  + N  SR ++ QE Y+ S SGSEDE+     FW 
Sbjct: 239 GEETSVRSWP--REESNTRSRHRAKHQTNPRSRPRSKQEAYVDSWSGSEDEASNPFSFWV 296

Query: 266 RDKTNTWSGP--REDPNSRSRFRSKKEVYVESSSGSEHEDHLESWFGAGKEAKFRSKMRA 323
            + TN    P  RE+ N RS+ R+ +E   ES   SE E + +SW            +  
Sbjct: 297 GENTNNLFRPRVREEANIRSKLRTNREDCFESE--SEDEFYKQSW------------VLP 342

Query: 324 GKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPEENANTFSRPMIKKEARARAMTKE 383
           G+EAN+R RHR K                        E+ NT             A+   
Sbjct: 343 GEEANSRFRHRDK------------------------EDPNT-------------ALKLR 365

Query: 384 EAKTKARARAKQEARSEEEALIGTWFWATDESSMADEAS--IESSLQVEDESIIGSWFWT 441
             K     R KQE R EEE +IG+WFWA  E+S+   AS   ES    E+ +I GS +W 
Sbjct: 366 AQKDVDSDRVKQEPRFEEEVIIGSWFWAEKEASLEGGASAICESEPGTEEGAIGGSAYWA 425

Query: 442 EEEASMGTGASSKSRPRTDGERIGDSLFGAREK 474
           EE++S+G  A  +++P ++ E I  S F  R++
Sbjct: 426 EEKSSLGAVAREEAKPESEEEAIFGSWFWDRDE 458



 Score =  144 bits (364), Expect = 5e-34
 Identities = 145/553 (26%), Positives = 218/553 (39%), Gaps = 104/553 (18%)

Query: 86  SRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASPLVSTDSVLVAKTKYLSEDRELVNTD 145
           +  +  AQ   + + G E ++  ER +   ++  P V T +   A+ K          T+
Sbjct: 4   AEIEPSAQAKPEKKAGEEVIAGPERENDVPLVVRPKVRTQATTGARPK----------TE 53

Query: 146 TESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRPTSK--QEASPNSDFKWVDKSVSSLF 203
           T+S P  +   +A      R K E  +     P+  ++    A P +D + V  + S   
Sbjct: 54  TKSVPAARPKTEAQAMSGARPKTEVQVMGGARPKTEAQGITGARPKTDARAVGGARS--- 110

Query: 204 WSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQTNQELYIASSSGSEDESVKTPWF 263
               +  AK  PG R KD          EA   ++S+   E    +   S+  +V  P  
Sbjct: 111 ----KTDAKAIPGARPKD----------EAQAWAQSEFGTEAVSQAEGVSQTNAVAWPLA 156

Query: 264 WARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSEHEDHLESWFGAGKEAKFRSKMRA 323
            A       SG        S  R    V  E+  G++ +  ++ WFG G+E    S   +
Sbjct: 157 TAE------SGSVTKSKGLSMDRELVNVDAETFPGTQGQKGIQPWFGPGEETNMGSWCYS 210

Query: 324 GKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPEENANTFSRPMIKKEARARAMTKE 383
                   R RA+ EA  +    S D     S FW  E  +  S P  +   R+R   K 
Sbjct: 211 --------RPRAREEASNESGFWSADETSTASSFWTGEETSVRSWPREESNTRSRHRAKH 262

Query: 384 EAKTKARARAKQEAR------SEEEALIGTWFWATDESS------MADEASIESSLQV-- 429
           +   ++R R+KQEA       SE+EA     FW  + ++      + +EA+I S L+   
Sbjct: 263 QTNPRSRPRSKQEAYVDSWSGSEDEASNPFSFWVGENTNNLFRPRVREEANIRSKLRTNR 322

Query: 430 --------EDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTGA 481
                   EDE    SW    EEA+                    S F  R+K    T  
Sbjct: 323 EDCFESESEDEFYKQSWVLPGEEAN--------------------SRFRHRDKEDPNTAL 362

Query: 482 EATSESILAADDEQVIIGSWFWAGEEVNQEA--EEETIFGSWFWVIDAASVESGVGVSCE 539
           +  ++  + +D               V QE   EEE I GSWFW    AS+E G    CE
Sbjct: 363 KLRAQKDVDSD--------------RVKQEPRFEEEVIIGSWFWAEKEASLEGGASAICE 408

Query: 540 SRTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMD---CRA 596
           S   +EE  + G  +W+ E+  + A   EEA+P +EEE IFGSWFW  ++   D   C  
Sbjct: 409 SEPGTEEGAIGGSAYWAEEKSSLGAVAREEAKPESEEEAIFGSWFWDRDEACFDLNPCPV 468

Query: 597 ETSCDTMQGAEEE 609
               D  + A EE
Sbjct: 469 YKVSDRFRDAAEE 481



 Score =  104 bits (259), Expect = 7e-22
 Identities = 128/499 (25%), Positives = 197/499 (39%), Gaps = 113/499 (22%)

Query: 368 RPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADEASIESSL 427
           RP ++ +A   A  K E K+   AR K EA++   A   T                    
Sbjct: 37  RPKVRTQATTGARPKTETKSVPAARPKTEAQAMSGARPKT-------------------- 76

Query: 428 QVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKT--GAEATS 485
             E + + G+   TE +   G      +RP+TD   +G    GAR KT  K   GA    
Sbjct: 77  --EVQVMGGARPKTEAQGITG------ARPKTDARAVG----GARSKTDAKAIPGARPKD 124

Query: 486 ESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESG------------ 533
           E+   A  E          G E   +AE  +   +  W +  A+ ESG            
Sbjct: 125 EAQAWAQSE---------FGTEAVSQAEGVSQTNAVAWPL--ATAESGSVTKSKGLSMDR 173

Query: 534 --VGVSCESRTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTY 591
             V V  E+   ++ ++ I PWF  GE+ ++  G    +RP A EE    S FW+ ++T 
Sbjct: 174 ELVNVDAETFPGTQGQKGIQPWFGPGEETNM--GSWCYSRPRAREEASNESGFWSADET- 230

Query: 592 MDCRAETSCDTMQGAEEEEPIIGSW----FWTRVEACVEGDVNSKSSLEDKEEAMIPCFG 647
                 T+     G   EE  + SW      TR     +   N +S    K+EA +  + 
Sbjct: 231 -----STASSFWTG---EETSVRSWPREESNTRSRHRAKHQTNPRSRPRSKQEAYVDSWS 282

Query: 648 AKEE-----VSMKHGTGVRCRFMAGAEE---------TNNKSCFWAEKEPCMYPAG---- 689
             E+      S   G      F     E         TN + CF +E E   Y       
Sbjct: 283 GSEDEASNPFSFWVGENTNNLFRPRVREEANIRSKLRTNREDCFESESEDEFYKQSWVLP 342

Query: 690 ----GGSWKSRPEEE----------EDIVNSWFWSRKYTKPEAIIGSWLWATEESNIDGT 735
                  ++ R +E+          +D+ +         + E IIGSW WA +E++++G 
Sbjct: 343 GEEANSRFRHRDKEDPNTALKLRAQKDVDSDRVKQEPRFEEEVIIGSWFWAEKEASLEGG 402

Query: 736 GE---KAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIGSWFWAGEEDRLE 792
                +++  TEE  I  S +W E+++   A  REE++PE+EE  I GSWFW  +E   +
Sbjct: 403 ASAICESEPGTEEGAIGGSAYWAEEKSSLGAVAREEAKPESEEEAIFGSWFWDRDEACFD 462

Query: 793 ----PAAETREEDRLAAEK 807
               P  +  +  R AAE+
Sbjct: 463 LNPCPVYKVSDRFRDAAEE 481



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 80/291 (27%), Positives = 115/291 (39%), Gaps = 47/291 (16%)

Query: 802  RLAAEKEGIVGSWFGAREETIRREAGSC-SKSSPKAEEEEVIIGSWFWEEEASPEAVAGV 860
            R   E +GI G    AR +T  R  G   SK+  KA      I     ++EA   A +  
Sbjct: 85   RPKTEAQGITG----ARPKTDARAVGGARSKTDAKA------IPGARPKDEAQAWAQSEF 134

Query: 861  GFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEE---MESE---TEEETIFGS----- 909
            G E+    E    T  +  WP   A+ ++GS    +   M+ E    + ET  G+     
Sbjct: 135  GTEAVSQAEGVSQT-NAVAWPL--ATAESGSVTKSKGLSMDRELVNVDAETFPGTQGQKG 191

Query: 910  ---WFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESKPENEEG 966
               WF  G+E +   G  C S+P   EE   ES FWS D    ET T ++  +  E    
Sbjct: 192  IQPWFGPGEETN--MGSWCYSRPRAREEASNESGFWSAD----ETSTASSFWTGEETS-- 243

Query: 967  AIVGSW--FEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAH------FESNP 1018
              V SW   E+     +R  + +N  SR    + EA V SW  + DEA          N 
Sbjct: 244  --VRSWPREESNTRSRHRAKHQTNPRSRP-RSKQEAYVDSWSGSEDEASNPFSFWVGENT 300

Query: 1019 SPVFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFR 1069
            + +FR   R   ++  +   +R      E   +F    W   G  + S FR
Sbjct: 301  NNLFRPRVREEANIRSKLRTNREDCFESESEDEFYKQSWVLPGEEANSRFR 351


>gi|239757861 PREDICTED: similar to armadillo repeat containing,
            X-linked 4 [Homo sapiens]
          Length = 2382

 Score =  257 bits (656), Expect = 6e-68
 Identities = 370/1513 (24%), Positives = 606/1513 (40%), Gaps = 262/1513 (17%)

Query: 17   KPGEEVVGGAEIENDVPLVVRPKV--RTQAQIMPGARPKNKSK------------VMPGA 62
            K    VV  A    D     +P+V   +Q + +PGAR K K              +M   
Sbjct: 981  KGNSNVVSKAGAREDTMGSAQPQVVANSQRETLPGARNKVKGNSNAISKAEAGAGIMGSV 1040

Query: 63   STKVETSAVGGARPKSKAK------AIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNI 116
              +V  S  G   P +K K      A+P +    +    AQP+  A   S+T   ++  +
Sbjct: 1041 QVQVVASFQGEVLPGAKNKVRGNSNAVPKAEAGADTVGSAQPQAVANSQSETLLGARNKV 1100

Query: 117  IASPLVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWC 176
              + +    +   A T++ ++ + +  +  E+ P  +    +  +    +++E       
Sbjct: 1101 KGNTIAVPKAGTGAGTRHSAQPQIVAGSQGETLPGARDKSMSTSEAEATAEDEAYAKPEA 1160

Query: 177  CPRPTSKQEASPNSDF-KWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANT 235
               PTS+ E    +   +    ++   +W+G  V         +K   R   M     N+
Sbjct: 1161 EAMPTSESEGGSGTQACRKTQPNIHDYYWNGIGVEDWIAAERWIKF--RFQTMDGDWENS 1218

Query: 236  MSRSQTNQELYIASSSGSEDES-VKTPWFWARDKTN--TWSGPREDPN------SRSRFR 286
            +S +    E  I S SG+ D++ +   W  A D+T+  +W+G R +        +R+  +
Sbjct: 1219 VSWADDENEASIGSWSGASDKAGIIRSWAVACDETSVKSWAGARAENVVGIGTWARAGEQ 1278

Query: 287  SKKEVYV--ESSSGSEHEDHLE--SWFGAGKEAKFRSKMRAGKEANNRARHRAKREACID 342
            +   ++   ++S G+   D     +W GA  +A   S   AG +A        +      
Sbjct: 1279 ASGGLWAGGQTSEGTWAGDKASGGAWTGAENQASGGSWALAGNQAIGELWAAGQAS---- 1334

Query: 343  FMPGSIDVIKKESCFWPEENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEE 402
               GS          WP   A+  S   + +EA   + T                 +E +
Sbjct: 1335 --DGS----------WPGGQASGVS--WVGEEAIGGSWTG----------------AENQ 1364

Query: 403  ALIGTWFWATDESSMADEASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGE 462
            A  G+W  A       + +S+     V D++  GSW  T +++  G      S+PR + +
Sbjct: 1365 ASEGSWAGA----GAGNMSSVSYWAGVVDQAGGGSWAGTSDQSGGG------SKPRFEDQ 1414

Query: 463  RIGDSLFGAREKTSMKTGAEATSESILAADDEQVIIGSWFWAGEEVNQEAE----EETIF 518
              G+  +          G +A+  S+L  +D Q    SW    ++ +  +     +++  
Sbjct: 1415 ASGEGSWAG-------AGGQASGGSMLGPED-QSSGRSWADTADQASGGSRLGHVDQSSG 1466

Query: 519  GSWFWVIDAASVESGVGVSCESRTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEET 578
            G+W   +D    +SG G       ++ EE   G W  +G Q       G  ++ G E+++
Sbjct: 1467 GAWAGTLD----QSGGGSKPRFENQTTEE---GSWAGAGGQA------GGGSKVGPEDQS 1513

Query: 579  IFGSWFWAENQTYMDCRAETSCDTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDK 638
               SW  + +Q         S   + G  ++    GSW      A     V  K   ED+
Sbjct: 1514 SGRSWANSGDQI--------SGGFLVGIVDQANG-GSW----TGAGHPASVGPKPIFEDQ 1560

Query: 639  EEAMIPCFGAKEEVSMKHGTGVRCRFMAGA-EETNNKSCFWAEKEPCMYPAG---GGSWK 694
                     A+E+V      G+R +    +   T +++  W     C+ P     GGSW 
Sbjct: 1561 VSGRGSWADAREQVVGDSRLGLRDQSSGDSWAGTGDQASGWF----CVCPGSQTNGGSWG 1616

Query: 695  ---------SRP-EEEEDIVNSWFWSRKYTKPEAIIGSWLWATEESNIDGTGEKAKLLTE 744
                     SRP    +    SW        P + +    W T    +D  G  +K   E
Sbjct: 1617 GASGQDVGGSRPGPTNQSSAGSW------DSPGSQVSGSCW-TGAGAVDQAGGCSKPGFE 1669

Query: 745  EETIINSWFWKEDEAISEATDREE--SRPEAEEGDI-IGSWFWAGEE----DRLEPAAET 797
            ++ I    FW        A D+    SRP +E+    IGSW  AG +     R  PA ++
Sbjct: 1670 DQAI-GGGFWPG------AGDQTGGGSRPGSEDQSSGIGSWGVAGGQVLGGARPGPADQS 1722

Query: 798  REEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEEVIIGSWFWE-EEASPEA 856
                      +    SW G  ++ +      CSK  P+ E++    GSW     +AS E+
Sbjct: 1723 SGGSWAGTGNQSSGRSWIGPGDQAV-----DCSK--PEFEDQACGGGSWAGAGSQASGES 1775

Query: 857  VAGVGFESKPGTE---------EEEITVGSWFWPEEEAS----IQAGSQAVEEMESETEE 903
             AG    S+PG E         E++ T GSW   E++AS    +    +A E        
Sbjct: 1776 WAG----SRPGNEAIGGSRMGSEDQATGGSWARSEDQASGRFQVSFEVEANEGFWFGPGA 1831

Query: 904  ETIFGSWFW-----------DGKE---------VSEEAGPCCVSKPEDDEEMIVESWFWS 943
            E + GSW W           D K+           EEA  C  S+ E + +    SW  S
Sbjct: 1832 EAVIGSWCWTEEKADIVSRPDDKDEATTASRSRAGEEAMIC--SRIEAENKASSGSWIRS 1889

Query: 944  RDKAIK------------------ETGTVATCESK----------PENEEGAIVGSWFEA 975
             + A                    E G  A  E+           P  E GA V SW   
Sbjct: 1890 EEVAYMGSCVGAEAGAGAEAGAGAEAGAGAGAEAGAEAGAGAGAGPGTESGAGVWSWDGD 1949

Query: 976  EDEVDNRTDNGSNCG--SRTLA--------------DEDEAIVGSWFWAGDEAHFESNPS 1019
               V++R   G   G  S TLA              D +E  + S FWA      ES  S
Sbjct: 1950 ATTVESRLGAGEEAGVESWTLARNVGEDELSRESSPDIEEISLRSLFWA------ESENS 2003

Query: 1020 PVFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRF-PKEAASLF 1078
              FR+      S E     +   +   E       G W   G  + S  +  PK  A   
Sbjct: 2004 NTFRSKSGKDASFESGAGDNTSIKDKFEAAGGVDIGSWFCAGNENTSEDKSAPKAKAKKS 2063

Query: 1079 CEMFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPE 1138
             E  G  P  +  +  G    +++  +    +F  Q + S+    E R+  R  E T P 
Sbjct: 2064 SESRGIYPYMVPGAGMGSWDGAMIWSET---KFAHQSEASFPVEDESRKQTRTGEKTRPW 2120

Query: 1139 SSSCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVV 1198
            S  C   + E  +   + E+L+ ++E   DP +HEI+  A+   +   ++ + +R+ G +
Sbjct: 2121 SCRC---KHEANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSADYSYSHEVVRNVGGI 2177

Query: 1199 SLIETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGI 1258
            S+IE+LLN P   VR   L  +  ++    N   ++TY+ +VCE+T+ Y ++S  QL+G+
Sbjct: 2178 SVIESLLNNPYPSVRQKALNALNNISVAAENHRKVKTYLNQVCEDTVTYPLNSNVQLAGL 2237

Query: 1259 RMIRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEA 1318
            R+IRHLT T++Y  +V NY+S FL LL  G+ +T+ HVL MLLN S+N  MTK+LL A A
Sbjct: 2238 RLIRHLTITSEYQHMVTNYISEFLRLLTVGSGETKDHVLGMLLNFSKNPSMTKDLLIANA 2297

Query: 1319 VSEFIGLFNREETNDNIQIVLAIFENIGNNIKKET-VFSDDDFNIEPLISAFHKVEKFAK 1377
             +  I +F+++ET +NI   L++FENI  + K+    F+ D F+   L   F + +  AK
Sbjct: 2298 PTSLINIFSKKETKENILNALSLFENINYHFKRRAKAFTQDKFSKNSLYFLFQRPKACAK 2357

Query: 1378 ELQGKTDNQNDPE 1390
            +L+      NDPE
Sbjct: 2358 KLRALAAECNDPE 2370



 Score = 78.2 bits (191), Expect = 5e-14
 Identities = 216/1020 (21%), Positives = 372/1020 (36%), Gaps = 210/1020 (20%)

Query: 38   PKVRTQAQIMPGARPKNKSKVMPGASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQ 97
            P V  +A++  GA    + ++M  AS+K E       + K  + A+  +    +     Q
Sbjct: 744  PNVVLKAEVGEGAMGTAQLQIM--ASSKGEALLDSKNKVKGNSNAVSKAGAGTDTTGSVQ 801

Query: 98   PRFGAERLSKTERNSQTNIIASPLVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQ 157
            P+  A    +    ++  I  +P    +S +   T   +  + + N+  E  P  K   +
Sbjct: 802  PQIVANSQGEVLPGAKNKIRGNPTTVPNSGVGPYTTDSARPQAVANSQGEVLPGAKNKVK 861

Query: 158  AGFQPSFRSKEETNMGSWCCPRPTSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGN 217
            A       SK E  MG+    +P    +A  NS  + +  + + +  + + V+ K   G 
Sbjct: 862  ANLNAV--SKAEAGMGATGSVQP----QAVANSHCETLPGAKNKVRGNWNAVS-KAGAGM 914

Query: 218  RVKDSNRSMHMANQEANTM--SRSQTNQELYIASSSGSEDESVKT--PWFWARDKTNTWS 273
              + S +   +AN +   +  ++++      + S +G+ +++V +  P   A  +  T  
Sbjct: 915  DTRGSAQPQAVANSQGEVLPGAKNKVKGNPNVVSKAGAREDTVGSTQPQVLASSQRETLP 974

Query: 274  GPREDPNSRSRFRSKKEVYVESSSGSEHE----DHLESWFGAGKEAKFRSKMRAGKEANN 329
            G R      S   SK     ++   ++ +       E+  GA  + K  S   +  EA  
Sbjct: 975  GARNKVKGNSNVVSKAGAREDTMGSAQPQVVANSQRETLPGARNKVKGNSNAISKAEAGA 1034

Query: 330  RARHRAKREACIDF----MPGSIDVIKKESCFWPEENANTFSRPMIKKEARARAMTKEEA 385
                  + +    F    +PG+ + ++  S   P+  A                     A
Sbjct: 1035 GIMGSVQVQVVASFQGEVLPGAKNKVRGNSNAVPKAEAG--------------------A 1074

Query: 386  KTKARARAKQEARSEEEALIGTWFWATDESSMADEASIESSLQVEDESIIGSWFWTEEEA 445
             T   A+ +  A S+ E L+G                  +  +V+  +I         +A
Sbjct: 1075 DTVGSAQPQAVANSQSETLLG------------------ARNKVKGNTI------AVPKA 1110

Query: 446  SMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTGAEATSESILAADDEQVIIGSWFWAG 505
              G G    ++P+      G++L GAR+K+   + AEAT+E                   
Sbjct: 1111 GTGAGTRHSAQPQIVAGSQGETLPGARDKSMSTSEAEATAE------------------- 1151

Query: 506  EEVNQEAEEETIFGSWFWVIDAASVESGVGVSCESRTRSEEEEVIGPWFWSGEQVDIEAG 565
            +E   + E E         +  +  E G G     +T+      I  ++W+G  + +E  
Sbjct: 1152 DEAYAKPEAE--------AMPTSESEGGSGTQACRKTQPN----IHDYYWNG--IGVEDW 1197

Query: 566  IGEEARPGAEEETIFGSWFWAENQTYMDCRAETSCDTMQGAEEEEPIIGSWFWTRVEACV 625
            I  E       +T+ G   W  + ++ D   E S  +  GA ++  II SW      AC 
Sbjct: 1198 IAAERWIKFRFQTMDGD--WENSVSWADDENEASIGSWSGASDKAGIIRSW----AVACD 1251

Query: 626  EGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGVRC------RFMAGAEETNNKSCFWA 679
            E  V S +             GA+ E  +  GT  R          AG + +      WA
Sbjct: 1252 ETSVKSWA-------------GARAENVVGIGTWARAGEQASGGLWAGGQTSEGT---WA 1295

Query: 680  EKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAIIGSWLWATEESNIDGT--GE 737
              +     A GG+W     E +    SW  +      E      LWA  +++ DG+  G 
Sbjct: 1296 GDK-----ASGGAWTG--AENQASGGSWALAGNQAIGE------LWAAGQAS-DGSWPGG 1341

Query: 738  KAKLLT--EEETIINSWFWKEDEAI------SEATDREESRPEAEEGDIIGSWFWAGEED 789
            +A  ++   EE I  SW   E++A       + A +       A   D  G   WAG  D
Sbjct: 1342 QASGVSWVGEEAIGGSWTGAENQASEGSWAGAGAGNMSSVSYWAGVVDQAGGGSWAGTSD 1401

Query: 790  RLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEEVIIGSWFWE 849
            +    ++ R ED+ + E     GSW GA         G  S  S    E++    SW   
Sbjct: 1402 QSGGGSKPRFEDQASGE-----GSWAGA--------GGQASGGSMLGPEDQSSGRSW--- 1445

Query: 850  EEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESETEEETIFGS 909
             + + +A  G    S+ G   ++ + G+W    +    Q+G  +    E++T EE   GS
Sbjct: 1446 ADTADQASGG----SRLG-HVDQSSGGAWAGTLD----QSGGGSKPRFENQTTEE---GS 1493

Query: 910  WFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDK----------------AIKETGT 953
            W   G     +AG      PED       SW  S D+                +    G 
Sbjct: 1494 WAGAG----GQAGGGSKVGPEDQSS--GRSWANSGDQISGGFLVGIVDQANGGSWTGAGH 1547

Query: 954  VATCESKPENEEGAI-VGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEA 1012
             A+   KP  E+     GSW +A ++V          G   L   D++   SW   GD+A
Sbjct: 1548 PASVGPKPIFEDQVSGRGSWADAREQV---------VGDSRLGLRDQSSGDSWAGTGDQA 1598



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 124/580 (21%), Positives = 227/580 (39%), Gaps = 111/580 (19%)

Query: 4   AEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMPGAS 63
           AEI++  QV+   + G     GAE+E     +   +  +QA+ M GA P+ +S+    A 
Sbjct: 155 AEIKTKPQVEIGAETGARSGPGAEVETKATAIAIHRANSQAKAMVGAEPETQSESKVVAG 214

Query: 64  TKVETSAVGGARPKSKAKAIPVSR------------------FKEEAQMWA-QPRFGAER 104
           T V T AV     K+KA+ + +                     + +A+ WA   +  A+R
Sbjct: 215 TLVMTEAVTLTEVKAKAREVAMKEAVTQTDAEAGKIVKKEAVTQTKAKAWALVAKTEAKR 274

Query: 105 LSKTERNSQTNIIASPLVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGF--QP 162
            + T+  ++T+I+A      + V+V +++ L+  RE+         +  A  + G   + 
Sbjct: 275 EAMTQTKAETHILAEKETEINRVMVTQSETLAVPREVA--------KMGATNKTGIVDET 326

Query: 163 SFRSKEET----NMGSWCCPRPTSKQEASPNS--------DFKWVDKSVSSLFWSGDEVT 210
             R+ EET       S   P  T     +PN         D K   +S +     GD++ 
Sbjct: 327 KTRALEETVSVAKTQSEARPGATVDARGNPNGMSREVAGVDMKSCAQSQAVTKIQGDDM- 385

Query: 211 AKFHPGNRVKDSNRSMHMANQEANTMSRSQTNQELYIAS--------------------- 249
               PG  V+D      M+  E+   +R+    +++  +                     
Sbjct: 386 ----PGTGVEDMGNCKTMSRAESGADTRASAQPQIFAKTQTEAIPGAKIDAGGNTNAMCK 441

Query: 250 -SSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSEHEDHLESW 308
             +G++  +   P   A+ +    SG R D    +   SK     +  + ++ +    + 
Sbjct: 442 VGAGADVRACIQPQTVAKKQAEVTSGARVDGRGNTNVISKAITGADMRAAAQPQAVASTH 501

Query: 309 FGAGKEAKFRSK------MRAGKEANNRARHRAKR-EACIDFMPGSIDVIKKE------- 354
             A  +AK +++       +AG +AN RA  + +      D   G+ +V+ K        
Sbjct: 502 AEAMSDAKVKNRGNPNAMTKAGAKANLRANSQVEALPDARDKSRGNPNVMAKVGDGTDML 561

Query: 355 SCFWPE----ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFW 410
           SC  P+      A+T S   IK       M KE A    +A+    A+S+ EAL  T   
Sbjct: 562 SCTQPQLVASVQADTLSDGKIKVRGNVNTMPKEGAGVDMKAQGM--AQSQGEALPNTRGK 619

Query: 411 ATDES----------SMADEASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTD 460
           A  ++           M      ++ ++   E+++ S        +  + A +K+  R  
Sbjct: 620 ARGKAKAKCKTGPGMDMKTCTQPQAGVKTPAEALLDSRVDGRGNPNATSKAGTKADQRVC 679

Query: 461 GERI------GDSLFGAREK------TSMKTGA-EATSES 487
           G+ +      G++L GA+ K      T +K GA E T++S
Sbjct: 680 GQPLVVANPQGEALPGAKNKVKGNPHTVLKVGAGEGTTDS 719


>gi|216547715 basic helix-loop-helix domain containing, class B, 9
            [Homo sapiens]
          Length = 547

 Score =  236 bits (601), Expect = 1e-61
 Identities = 176/599 (29%), Positives = 299/599 (49%), Gaps = 67/599 (11%)

Query: 795  AETREEDRLAA--EKEGIVGSWFGAREET---IRREAGSCSKSSPKAEEEEVIIGSWFWE 849
            A T+ + R  A  EK+  + +  GA  E    +R  A + +K+  K   +   +      
Sbjct: 2    AGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVA----- 56

Query: 850  EEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESETEEETIFGS 909
             E    +   V  E+K G   E  T+G       + + +AG+   E   S  + E    +
Sbjct: 57   -EMKAVSKNKVVAETKEGALSEPKTLGKAMG---DFTPKAGN---ESTSSTCKNEAGTDA 109

Query: 910  WFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESKPENEEGAIV 969
            WFW G                  EE  + SWFW+ ++A     + +T   KPE      +
Sbjct: 110  WFWAG------------------EEATINSWFWNGEEA---GNSFSTKNDKPE------I 142

Query: 970  GSWFEAEDEVDNRTDNGSNCGSRTLADEDEA--IVGSWFWAGDEAHFESNPSPVFRAICR 1027
            G+   AE+        G++C  R+ A+E+E   ++G+WFW GD+  F+ NP PV R +  
Sbjct: 143  GAQVCAEEL---EPAAGADCKPRSGAEEEEEENVIGNWFWEGDDTSFDPNPKPVSRIVKP 199

Query: 1028 STCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRF--PKEAASLFCEMFGGK 1085
                   E +   RP+ W EVT+     P      P++  FR   P EA+     +    
Sbjct: 200  QPV---YEINEKNRPKDWSEVTIW----PNAPAVTPAVLGFRSQAPSEASPPSYIVLASA 252

Query: 1086 PRNMVLSPEG---EDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESSSC 1142
              N    P         +     QP PE  F  DP  +++ EIR  +R +E    +  +C
Sbjct: 253  EENACSLPVATACRPSRNTRSCSQPIPECRFDSDPCIQTIDEIRRQIRIREVNGIKPFAC 312

Query: 1143 NCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIE 1202
             C + E  + SEEFE+L+ L++   DP IH+I++IAMG+ +   F ++FI + GVV+LIE
Sbjct: 313  PC-KMECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQEFINEVGVVTLIE 371

Query: 1203 TLLNYPSSRVRTSFLENMIRMAPPYPN--LNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1260
            +LL++PS  +R    + +I + PP  +     I+ ++  +C+ET+++ ++SP Q SG+++
Sbjct: 372  SLLSFPSPEMRK---KTVITLNPPSGDERQRKIELHVKHMCKETMSFPLNSPGQQSGLKI 428

Query: 1261 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1320
            +  LTT   +H +VANY S    LL++GN KTR  VLK+LLN+SEN    +++++ +A++
Sbjct: 429  LGQLTTDFVHHYIVANYFSELFHLLSSGNCKTRNLVLKLLLNMSENPTAARDMINMKALA 488

Query: 1321 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKEL 1379
                +FN++E   N+   +AIF NI  +I+K ++   D  +   L++ F +V++  + +
Sbjct: 489  ALKLIFNQKEAKANLVSGVAIFINIKEHIRKGSIVVVDHLSYNTLMAIFREVKEIIETM 547



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 55/196 (28%), Positives = 86/196 (43%), Gaps = 17/196 (8%)

Query: 372 KKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADEASIESSLQVED 431
           K + RA+A T+++A  +A+A A++EA      +  T   A  ++    +A  E    V  
Sbjct: 5   KNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVAEMKA-VSK 63

Query: 432 ESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGA-REKTSMKTGAEATSESILA 490
             ++             T   + S P+T G+ +GD    A  E TS     EA +++   
Sbjct: 64  NKVVAE-----------TKEGALSEPKTLGKAMGDFTPKAGNESTSSTCKNEAGTDAWFW 112

Query: 491 ADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCESRTRSEEEE-- 548
           A +E  I  SWFW GEE       +         + A  +E   G  C+ R+ +EEEE  
Sbjct: 113 AGEEATI-NSWFWNGEEAGNSFSTKNDKPEIGAQVCAEELEPAAGADCKPRSGAEEEEEE 171

Query: 549 -VIGPWFWSGEQVDIE 563
            VIG WFW G+    +
Sbjct: 172 NVIGNWFWEGDDTSFD 187



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 57/204 (27%), Positives = 93/204 (45%), Gaps = 37/204 (18%)

Query: 323 AGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPEENANTFSRPMIKKEARARAMT- 381
           AG +   RA+ + +++A I    G+            E  A    RP+ K  A+A+A T 
Sbjct: 2   AGTKNKTRAQAKTEKKAAIQAKAGA------------EREATGVVRPVAKTRAKAKAKTG 49

Query: 382 ---------KEEAKTKARARAKQEARSEEEAL---IGTWF-WATDESSMA---DEASIES 425
                    K  +K K  A  K+ A SE + L   +G +   A +ES+ +   +EA  ++
Sbjct: 50  SKTDAVAEMKAVSKNKVVAETKEGALSEPKTLGKAMGDFTPKAGNESTSSTCKNEAGTDA 109

Query: 426 SLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTGAEATS 485
                +E+ I SWFW  EEA  G   S+K+    D   IG  +    E+     GA+   
Sbjct: 110 WFWAGEEATINSWFWNGEEA--GNSFSTKN----DKPEIGAQV--CAEELEPAAGADCKP 161

Query: 486 ESILAADDEQVIIGSWFWAGEEVN 509
            S    ++E+ +IG+WFW G++ +
Sbjct: 162 RSGAEEEEEENVIGNWFWEGDDTS 185



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 59/232 (25%), Positives = 93/232 (40%), Gaps = 40/232 (17%)

Query: 228 MANQEANTMSRSQTNQELYIASSSGSEDES--VKTPWFWARDKTNTWSGPREDPNSRSRF 285
           MA  +  T ++++T ++  I + +G+E E+  V  P    R K    +G + D  +  + 
Sbjct: 1   MAGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVAEMKA 60

Query: 286 RSKKEVYVESSSGSEHEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMP 345
            SK +V  E+  G+  E         GK A      +AG E+ +      K EA  D   
Sbjct: 61  VSKNKVVAETKEGALSEPKT-----LGK-AMGDFTPKAGNESTSST---CKNEAGTDAWF 111

Query: 346 GSIDVIKKESCFWP-EENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEAL 404
            + +     S FW  EE  N+FS    K E  A+    EE +  A A  K  + +EEE  
Sbjct: 112 WAGEEATINSWFWNGEEAGNSFSTKNDKPEIGAQVCA-EELEPAAGADCKPRSGAEEE-- 168

Query: 405 IGTWFWATDESSMADEASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSR 456
                                    E+E++IG+WFW  ++ S        SR
Sbjct: 169 -------------------------EEENVIGNWFWEGDDTSFDPNPKPVSR 195



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 31/108 (28%), Positives = 48/108 (44%), Gaps = 10/108 (9%)

Query: 687 PAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAIIGSWLWATEESNIDGTGEKAKLLTEEE 746
           P  G    S   + E   ++WFW+ +    EA I SW W  EE+     G       ++ 
Sbjct: 90  PKAGNESTSSTCKNEAGTDAWFWAGE----EATINSWFWNGEEA-----GNSFSTKNDKP 140

Query: 747 TIINSWFWKEDEAISEATDREESRPEAEEGD-IIGSWFWAGEEDRLEP 793
            I      +E E  + A  +  S  E EE + +IG+WFW G++   +P
Sbjct: 141 EIGAQVCAEELEPAAGADCKPRSGAEEEEEENVIGNWFWEGDDTSFDP 188



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 57/251 (22%), Positives = 96/251 (38%), Gaps = 57/251 (22%)

Query: 50  ARPKNKSKVMPGASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTE 109
           A  KNK++       K    A  GA  ++     PV++ + +A              K +
Sbjct: 2   AGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKA--------------KAK 47

Query: 110 RNSQTNIIASPLVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEE 169
             S+T+ +A      +   V+K K ++E +E       S P+        F P   ++  
Sbjct: 48  TGSKTDAVA------EMKAVSKNKVVAETKE----GALSEPKTLGKAMGDFTPKAGNEST 97

Query: 170 TNMGSWCCPRPTSKQEASPNSDFKWV--DKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMH 227
           ++         T K EA  ++ F W   + +++S FW+G+E    F   N   +    + 
Sbjct: 98  SS---------TCKNEAGTDAWF-WAGEEATINSWFWNGEEAGNSFSTKNDKPEIGAQVC 147

Query: 228 MANQE----ANTMSRSQTNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSR- 282
               E    A+   RS   +E         E+E+V   WFW  D T+       DPN + 
Sbjct: 148 AEELEPAAGADCKPRSGAEEE---------EEENVIGNWFWEGDDTSF------DPNPKP 192

Query: 283 -SRFRSKKEVY 292
            SR    + VY
Sbjct: 193 VSRIVKPQPVY 203



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 16/99 (16%)

Query: 684 CMYPAGGGSWKSRPEEEEDIVNSWFW---------SRKYTKPEAIIGSWLWATEESNIDG 734
           C   AG  +W    EE    +NSWFW         S K  KPE  IG+ + A E     G
Sbjct: 101 CKNEAGTDAWFWAGEEAT--INSWFWNGEEAGNSFSTKNDKPE--IGAQVCAEELEPAAG 156

Query: 735 TGEKAKLLTEEE---TIINSWFWKEDEAISEATDREESR 770
              K +   EEE    +I +WFW+ D+   +   +  SR
Sbjct: 157 ADCKPRSGAEEEEEENVIGNWFWEGDDTSFDPNPKPVSR 195



 Score = 38.5 bits (88), Expect = 0.046
 Identities = 36/120 (30%), Positives = 46/120 (38%), Gaps = 37/120 (30%)

Query: 590 TYMDCRAETSCDTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAK 649
           T   C+ E   D    A EE  I  SWFW   EA      NS S+  DK E  I      
Sbjct: 97  TSSTCKNEAGTDAWFWAGEEATI-NSWFWNGEEA-----GNSFSTKNDKPE--IGAQVCA 148

Query: 650 EEVSMKHGTGVRCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFW 709
           EE  ++   G  C+  +GAEE                           EEEE+++ +WFW
Sbjct: 149 EE--LEPAAGADCKPRSGAEE---------------------------EEEENVIGNWFW 179



 Score = 37.4 bits (85), Expect = 0.10
 Identities = 56/220 (25%), Positives = 81/220 (36%), Gaps = 35/220 (15%)

Query: 1   MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 60
           M G + ++ AQ K EKK   +   GA  E +   VVRP  +T+A+    A+ K  SK   
Sbjct: 1   MAGTKNKTRAQAKTEKKAAIQAKAGA--EREATGVVRPVAKTRAK----AKAKTGSKTDA 54

Query: 61  GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 120
            A  K  +     A  K  A + P +  K        P+ G E  S T +N         
Sbjct: 55  VAEMKAVSKNKVVAETKEGALSEPKTLGKAMGDF--TPKAGNESTSSTCKNE-------- 104

Query: 121 LVSTDSVLVAK-----TKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSW 175
              TD+   A        +     E  N    SF  +    + G Q      E    G+ 
Sbjct: 105 -AGTDAWFWAGEEATINSWFWNGEEAGN----SFSTKNDKPEIGAQVCAEELEPA-AGAD 158

Query: 176 CCPRPTSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHP 215
           C PR  +++E   N    W        FW GD+ +   +P
Sbjct: 159 CKPRSGAEEEEEENVIGNW--------FWEGDDTSFDPNP 190


>gi|216547682 basic helix-loop-helix domain containing, class B, 9
            [Homo sapiens]
          Length = 547

 Score =  236 bits (601), Expect = 1e-61
 Identities = 176/599 (29%), Positives = 299/599 (49%), Gaps = 67/599 (11%)

Query: 795  AETREEDRLAA--EKEGIVGSWFGAREET---IRREAGSCSKSSPKAEEEEVIIGSWFWE 849
            A T+ + R  A  EK+  + +  GA  E    +R  A + +K+  K   +   +      
Sbjct: 2    AGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVA----- 56

Query: 850  EEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESETEEETIFGS 909
             E    +   V  E+K G   E  T+G       + + +AG+   E   S  + E    +
Sbjct: 57   -EMKAVSKNKVVAETKEGALSEPKTLGKAMG---DFTPKAGN---ESTSSTCKNEAGTDA 109

Query: 910  WFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESKPENEEGAIV 969
            WFW G                  EE  + SWFW+ ++A     + +T   KPE      +
Sbjct: 110  WFWAG------------------EEATINSWFWNGEEA---GNSFSTKNDKPE------I 142

Query: 970  GSWFEAEDEVDNRTDNGSNCGSRTLADEDEA--IVGSWFWAGDEAHFESNPSPVFRAICR 1027
            G+   AE+        G++C  R+ A+E+E   ++G+WFW GD+  F+ NP PV R +  
Sbjct: 143  GAQVCAEEL---EPAAGADCKPRSGAEEEEEENVIGNWFWEGDDTSFDPNPKPVSRIVKP 199

Query: 1028 STCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRF--PKEAASLFCEMFGGK 1085
                   E +   RP+ W EVT+     P      P++  FR   P EA+     +    
Sbjct: 200  QPV---YEINEKNRPKDWSEVTIW----PNAPAVTPAVLGFRSQAPSEASPPSYIVLASA 252

Query: 1086 PRNMVLSPEG---EDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESSSC 1142
              N    P         +     QP PE  F  DP  +++ EIR  +R +E    +  +C
Sbjct: 253  EENACSLPVATACRPSRNTRSCSQPIPECRFDSDPCIQTIDEIRRQIRIREVNGIKPFAC 312

Query: 1143 NCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIE 1202
             C + E  + SEEFE+L+ L++   DP IH+I++IAMG+ +   F ++FI + GVV+LIE
Sbjct: 313  PC-KMECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQEFINEVGVVTLIE 371

Query: 1203 TLLNYPSSRVRTSFLENMIRMAPPYPN--LNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1260
            +LL++PS  +R    + +I + PP  +     I+ ++  +C+ET+++ ++SP Q SG+++
Sbjct: 372  SLLSFPSPEMRK---KTVITLNPPSGDERQRKIELHVKHMCKETMSFPLNSPGQQSGLKI 428

Query: 1261 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1320
            +  LTT   +H +VANY S    LL++GN KTR  VLK+LLN+SEN    +++++ +A++
Sbjct: 429  LGQLTTDFVHHYIVANYFSELFHLLSSGNCKTRNLVLKLLLNMSENPTAARDMINMKALA 488

Query: 1321 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKEL 1379
                +FN++E   N+   +AIF NI  +I+K ++   D  +   L++ F +V++  + +
Sbjct: 489  ALKLIFNQKEAKANLVSGVAIFINIKEHIRKGSIVVVDHLSYNTLMAIFREVKEIIETM 547



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 55/196 (28%), Positives = 86/196 (43%), Gaps = 17/196 (8%)

Query: 372 KKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADEASIESSLQVED 431
           K + RA+A T+++A  +A+A A++EA      +  T   A  ++    +A  E    V  
Sbjct: 5   KNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVAEMKA-VSK 63

Query: 432 ESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGA-REKTSMKTGAEATSESILA 490
             ++             T   + S P+T G+ +GD    A  E TS     EA +++   
Sbjct: 64  NKVVAE-----------TKEGALSEPKTLGKAMGDFTPKAGNESTSSTCKNEAGTDAWFW 112

Query: 491 ADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCESRTRSEEEE-- 548
           A +E  I  SWFW GEE       +         + A  +E   G  C+ R+ +EEEE  
Sbjct: 113 AGEEATI-NSWFWNGEEAGNSFSTKNDKPEIGAQVCAEELEPAAGADCKPRSGAEEEEEE 171

Query: 549 -VIGPWFWSGEQVDIE 563
            VIG WFW G+    +
Sbjct: 172 NVIGNWFWEGDDTSFD 187



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 57/204 (27%), Positives = 93/204 (45%), Gaps = 37/204 (18%)

Query: 323 AGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPEENANTFSRPMIKKEARARAMT- 381
           AG +   RA+ + +++A I    G+            E  A    RP+ K  A+A+A T 
Sbjct: 2   AGTKNKTRAQAKTEKKAAIQAKAGA------------EREATGVVRPVAKTRAKAKAKTG 49

Query: 382 ---------KEEAKTKARARAKQEARSEEEAL---IGTWF-WATDESSMA---DEASIES 425
                    K  +K K  A  K+ A SE + L   +G +   A +ES+ +   +EA  ++
Sbjct: 50  SKTDAVAEMKAVSKNKVVAETKEGALSEPKTLGKAMGDFTPKAGNESTSSTCKNEAGTDA 109

Query: 426 SLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTGAEATS 485
                +E+ I SWFW  EEA  G   S+K+    D   IG  +    E+     GA+   
Sbjct: 110 WFWAGEEATINSWFWNGEEA--GNSFSTKN----DKPEIGAQV--CAEELEPAAGADCKP 161

Query: 486 ESILAADDEQVIIGSWFWAGEEVN 509
            S    ++E+ +IG+WFW G++ +
Sbjct: 162 RSGAEEEEEENVIGNWFWEGDDTS 185



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 59/232 (25%), Positives = 93/232 (40%), Gaps = 40/232 (17%)

Query: 228 MANQEANTMSRSQTNQELYIASSSGSEDES--VKTPWFWARDKTNTWSGPREDPNSRSRF 285
           MA  +  T ++++T ++  I + +G+E E+  V  P    R K    +G + D  +  + 
Sbjct: 1   MAGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVAEMKA 60

Query: 286 RSKKEVYVESSSGSEHEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMP 345
            SK +V  E+  G+  E         GK A      +AG E+ +      K EA  D   
Sbjct: 61  VSKNKVVAETKEGALSEPKT-----LGK-AMGDFTPKAGNESTSST---CKNEAGTDAWF 111

Query: 346 GSIDVIKKESCFWP-EENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEAL 404
            + +     S FW  EE  N+FS    K E  A+    EE +  A A  K  + +EEE  
Sbjct: 112 WAGEEATINSWFWNGEEAGNSFSTKNDKPEIGAQVCA-EELEPAAGADCKPRSGAEEE-- 168

Query: 405 IGTWFWATDESSMADEASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSR 456
                                    E+E++IG+WFW  ++ S        SR
Sbjct: 169 -------------------------EEENVIGNWFWEGDDTSFDPNPKPVSR 195



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 31/108 (28%), Positives = 48/108 (44%), Gaps = 10/108 (9%)

Query: 687 PAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAIIGSWLWATEESNIDGTGEKAKLLTEEE 746
           P  G    S   + E   ++WFW+ +    EA I SW W  EE+     G       ++ 
Sbjct: 90  PKAGNESTSSTCKNEAGTDAWFWAGE----EATINSWFWNGEEA-----GNSFSTKNDKP 140

Query: 747 TIINSWFWKEDEAISEATDREESRPEAEEGD-IIGSWFWAGEEDRLEP 793
            I      +E E  + A  +  S  E EE + +IG+WFW G++   +P
Sbjct: 141 EIGAQVCAEELEPAAGADCKPRSGAEEEEEENVIGNWFWEGDDTSFDP 188



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 57/251 (22%), Positives = 96/251 (38%), Gaps = 57/251 (22%)

Query: 50  ARPKNKSKVMPGASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTE 109
           A  KNK++       K    A  GA  ++     PV++ + +A              K +
Sbjct: 2   AGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKA--------------KAK 47

Query: 110 RNSQTNIIASPLVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEE 169
             S+T+ +A      +   V+K K ++E +E       S P+        F P   ++  
Sbjct: 48  TGSKTDAVA------EMKAVSKNKVVAETKE----GALSEPKTLGKAMGDFTPKAGNEST 97

Query: 170 TNMGSWCCPRPTSKQEASPNSDFKWV--DKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMH 227
           ++         T K EA  ++ F W   + +++S FW+G+E    F   N   +    + 
Sbjct: 98  SS---------TCKNEAGTDAWF-WAGEEATINSWFWNGEEAGNSFSTKNDKPEIGAQVC 147

Query: 228 MANQE----ANTMSRSQTNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSR- 282
               E    A+   RS   +E         E+E+V   WFW  D T+       DPN + 
Sbjct: 148 AEELEPAAGADCKPRSGAEEE---------EEENVIGNWFWEGDDTSF------DPNPKP 192

Query: 283 -SRFRSKKEVY 292
            SR    + VY
Sbjct: 193 VSRIVKPQPVY 203



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 16/99 (16%)

Query: 684 CMYPAGGGSWKSRPEEEEDIVNSWFW---------SRKYTKPEAIIGSWLWATEESNIDG 734
           C   AG  +W    EE    +NSWFW         S K  KPE  IG+ + A E     G
Sbjct: 101 CKNEAGTDAWFWAGEEAT--INSWFWNGEEAGNSFSTKNDKPE--IGAQVCAEELEPAAG 156

Query: 735 TGEKAKLLTEEE---TIINSWFWKEDEAISEATDREESR 770
              K +   EEE    +I +WFW+ D+   +   +  SR
Sbjct: 157 ADCKPRSGAEEEEEENVIGNWFWEGDDTSFDPNPKPVSR 195



 Score = 38.5 bits (88), Expect = 0.046
 Identities = 36/120 (30%), Positives = 46/120 (38%), Gaps = 37/120 (30%)

Query: 590 TYMDCRAETSCDTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAK 649
           T   C+ E   D    A EE  I  SWFW   EA      NS S+  DK E  I      
Sbjct: 97  TSSTCKNEAGTDAWFWAGEEATI-NSWFWNGEEA-----GNSFSTKNDKPE--IGAQVCA 148

Query: 650 EEVSMKHGTGVRCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFW 709
           EE  ++   G  C+  +GAEE                           EEEE+++ +WFW
Sbjct: 149 EE--LEPAAGADCKPRSGAEE---------------------------EEEENVIGNWFW 179



 Score = 37.4 bits (85), Expect = 0.10
 Identities = 56/220 (25%), Positives = 81/220 (36%), Gaps = 35/220 (15%)

Query: 1   MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 60
           M G + ++ AQ K EKK   +   GA  E +   VVRP  +T+A+    A+ K  SK   
Sbjct: 1   MAGTKNKTRAQAKTEKKAAIQAKAGA--EREATGVVRPVAKTRAK----AKAKTGSKTDA 54

Query: 61  GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 120
            A  K  +     A  K  A + P +  K        P+ G E  S T +N         
Sbjct: 55  VAEMKAVSKNKVVAETKEGALSEPKTLGKAMGDF--TPKAGNESTSSTCKNE-------- 104

Query: 121 LVSTDSVLVAK-----TKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSW 175
              TD+   A        +     E  N    SF  +    + G Q      E    G+ 
Sbjct: 105 -AGTDAWFWAGEEATINSWFWNGEEAGN----SFSTKNDKPEIGAQVCAEELEPA-AGAD 158

Query: 176 CCPRPTSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHP 215
           C PR  +++E   N    W        FW GD+ +   +P
Sbjct: 159 CKPRSGAEEEEEENVIGNW--------FWEGDDTSFDPNP 190


>gi|216547672 basic helix-loop-helix domain containing, class B, 9
            [Homo sapiens]
          Length = 547

 Score =  236 bits (601), Expect = 1e-61
 Identities = 176/599 (29%), Positives = 299/599 (49%), Gaps = 67/599 (11%)

Query: 795  AETREEDRLAA--EKEGIVGSWFGAREET---IRREAGSCSKSSPKAEEEEVIIGSWFWE 849
            A T+ + R  A  EK+  + +  GA  E    +R  A + +K+  K   +   +      
Sbjct: 2    AGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVA----- 56

Query: 850  EEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESETEEETIFGS 909
             E    +   V  E+K G   E  T+G       + + +AG+   E   S  + E    +
Sbjct: 57   -EMKAVSKNKVVAETKEGALSEPKTLGKAMG---DFTPKAGN---ESTSSTCKNEAGTDA 109

Query: 910  WFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESKPENEEGAIV 969
            WFW G                  EE  + SWFW+ ++A     + +T   KPE      +
Sbjct: 110  WFWAG------------------EEATINSWFWNGEEA---GNSFSTKNDKPE------I 142

Query: 970  GSWFEAEDEVDNRTDNGSNCGSRTLADEDEA--IVGSWFWAGDEAHFESNPSPVFRAICR 1027
            G+   AE+        G++C  R+ A+E+E   ++G+WFW GD+  F+ NP PV R +  
Sbjct: 143  GAQVCAEEL---EPAAGADCKPRSGAEEEEEENVIGNWFWEGDDTSFDPNPKPVSRIVKP 199

Query: 1028 STCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRF--PKEAASLFCEMFGGK 1085
                   E +   RP+ W EVT+     P      P++  FR   P EA+     +    
Sbjct: 200  QPV---YEINEKNRPKDWSEVTIW----PNAPAVTPAVLGFRSQAPSEASPPSYIVLASA 252

Query: 1086 PRNMVLSPEG---EDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESSSC 1142
              N    P         +     QP PE  F  DP  +++ EIR  +R +E    +  +C
Sbjct: 253  EENACSLPVATACRPSRNTRSCSQPIPECRFDSDPCIQTIDEIRRQIRIREVNGIKPFAC 312

Query: 1143 NCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIE 1202
             C + E  + SEEFE+L+ L++   DP IH+I++IAMG+ +   F ++FI + GVV+LIE
Sbjct: 313  PC-KMECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQEFINEVGVVTLIE 371

Query: 1203 TLLNYPSSRVRTSFLENMIRMAPPYPN--LNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1260
            +LL++PS  +R    + +I + PP  +     I+ ++  +C+ET+++ ++SP Q SG+++
Sbjct: 372  SLLSFPSPEMRK---KTVITLNPPSGDERQRKIELHVKHMCKETMSFPLNSPGQQSGLKI 428

Query: 1261 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1320
            +  LTT   +H +VANY S    LL++GN KTR  VLK+LLN+SEN    +++++ +A++
Sbjct: 429  LGQLTTDFVHHYIVANYFSELFHLLSSGNCKTRNLVLKLLLNMSENPTAARDMINMKALA 488

Query: 1321 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKEL 1379
                +FN++E   N+   +AIF NI  +I+K ++   D  +   L++ F +V++  + +
Sbjct: 489  ALKLIFNQKEAKANLVSGVAIFINIKEHIRKGSIVVVDHLSYNTLMAIFREVKEIIETM 547



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 55/196 (28%), Positives = 86/196 (43%), Gaps = 17/196 (8%)

Query: 372 KKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADEASIESSLQVED 431
           K + RA+A T+++A  +A+A A++EA      +  T   A  ++    +A  E    V  
Sbjct: 5   KNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVAEMKA-VSK 63

Query: 432 ESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGA-REKTSMKTGAEATSESILA 490
             ++             T   + S P+T G+ +GD    A  E TS     EA +++   
Sbjct: 64  NKVVAE-----------TKEGALSEPKTLGKAMGDFTPKAGNESTSSTCKNEAGTDAWFW 112

Query: 491 ADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCESRTRSEEEE-- 548
           A +E  I  SWFW GEE       +         + A  +E   G  C+ R+ +EEEE  
Sbjct: 113 AGEEATI-NSWFWNGEEAGNSFSTKNDKPEIGAQVCAEELEPAAGADCKPRSGAEEEEEE 171

Query: 549 -VIGPWFWSGEQVDIE 563
            VIG WFW G+    +
Sbjct: 172 NVIGNWFWEGDDTSFD 187



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 57/204 (27%), Positives = 93/204 (45%), Gaps = 37/204 (18%)

Query: 323 AGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPEENANTFSRPMIKKEARARAMT- 381
           AG +   RA+ + +++A I    G+            E  A    RP+ K  A+A+A T 
Sbjct: 2   AGTKNKTRAQAKTEKKAAIQAKAGA------------EREATGVVRPVAKTRAKAKAKTG 49

Query: 382 ---------KEEAKTKARARAKQEARSEEEAL---IGTWF-WATDESSMA---DEASIES 425
                    K  +K K  A  K+ A SE + L   +G +   A +ES+ +   +EA  ++
Sbjct: 50  SKTDAVAEMKAVSKNKVVAETKEGALSEPKTLGKAMGDFTPKAGNESTSSTCKNEAGTDA 109

Query: 426 SLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTGAEATS 485
                +E+ I SWFW  EEA  G   S+K+    D   IG  +    E+     GA+   
Sbjct: 110 WFWAGEEATINSWFWNGEEA--GNSFSTKN----DKPEIGAQV--CAEELEPAAGADCKP 161

Query: 486 ESILAADDEQVIIGSWFWAGEEVN 509
            S    ++E+ +IG+WFW G++ +
Sbjct: 162 RSGAEEEEEENVIGNWFWEGDDTS 185



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 59/232 (25%), Positives = 93/232 (40%), Gaps = 40/232 (17%)

Query: 228 MANQEANTMSRSQTNQELYIASSSGSEDES--VKTPWFWARDKTNTWSGPREDPNSRSRF 285
           MA  +  T ++++T ++  I + +G+E E+  V  P    R K    +G + D  +  + 
Sbjct: 1   MAGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVAEMKA 60

Query: 286 RSKKEVYVESSSGSEHEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMP 345
            SK +V  E+  G+  E         GK A      +AG E+ +      K EA  D   
Sbjct: 61  VSKNKVVAETKEGALSEPKT-----LGK-AMGDFTPKAGNESTSST---CKNEAGTDAWF 111

Query: 346 GSIDVIKKESCFWP-EENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEAL 404
            + +     S FW  EE  N+FS    K E  A+    EE +  A A  K  + +EEE  
Sbjct: 112 WAGEEATINSWFWNGEEAGNSFSTKNDKPEIGAQVCA-EELEPAAGADCKPRSGAEEE-- 168

Query: 405 IGTWFWATDESSMADEASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSR 456
                                    E+E++IG+WFW  ++ S        SR
Sbjct: 169 -------------------------EEENVIGNWFWEGDDTSFDPNPKPVSR 195



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 31/108 (28%), Positives = 48/108 (44%), Gaps = 10/108 (9%)

Query: 687 PAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAIIGSWLWATEESNIDGTGEKAKLLTEEE 746
           P  G    S   + E   ++WFW+ +    EA I SW W  EE+     G       ++ 
Sbjct: 90  PKAGNESTSSTCKNEAGTDAWFWAGE----EATINSWFWNGEEA-----GNSFSTKNDKP 140

Query: 747 TIINSWFWKEDEAISEATDREESRPEAEEGD-IIGSWFWAGEEDRLEP 793
            I      +E E  + A  +  S  E EE + +IG+WFW G++   +P
Sbjct: 141 EIGAQVCAEELEPAAGADCKPRSGAEEEEEENVIGNWFWEGDDTSFDP 188



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 57/251 (22%), Positives = 96/251 (38%), Gaps = 57/251 (22%)

Query: 50  ARPKNKSKVMPGASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTE 109
           A  KNK++       K    A  GA  ++     PV++ + +A              K +
Sbjct: 2   AGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKA--------------KAK 47

Query: 110 RNSQTNIIASPLVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEE 169
             S+T+ +A      +   V+K K ++E +E       S P+        F P   ++  
Sbjct: 48  TGSKTDAVA------EMKAVSKNKVVAETKE----GALSEPKTLGKAMGDFTPKAGNEST 97

Query: 170 TNMGSWCCPRPTSKQEASPNSDFKWV--DKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMH 227
           ++         T K EA  ++ F W   + +++S FW+G+E    F   N   +    + 
Sbjct: 98  SS---------TCKNEAGTDAWF-WAGEEATINSWFWNGEEAGNSFSTKNDKPEIGAQVC 147

Query: 228 MANQE----ANTMSRSQTNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSR- 282
               E    A+   RS   +E         E+E+V   WFW  D T+       DPN + 
Sbjct: 148 AEELEPAAGADCKPRSGAEEE---------EEENVIGNWFWEGDDTSF------DPNPKP 192

Query: 283 -SRFRSKKEVY 292
            SR    + VY
Sbjct: 193 VSRIVKPQPVY 203



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 16/99 (16%)

Query: 684 CMYPAGGGSWKSRPEEEEDIVNSWFW---------SRKYTKPEAIIGSWLWATEESNIDG 734
           C   AG  +W    EE    +NSWFW         S K  KPE  IG+ + A E     G
Sbjct: 101 CKNEAGTDAWFWAGEEAT--INSWFWNGEEAGNSFSTKNDKPE--IGAQVCAEELEPAAG 156

Query: 735 TGEKAKLLTEEE---TIINSWFWKEDEAISEATDREESR 770
              K +   EEE    +I +WFW+ D+   +   +  SR
Sbjct: 157 ADCKPRSGAEEEEEENVIGNWFWEGDDTSFDPNPKPVSR 195



 Score = 38.5 bits (88), Expect = 0.046
 Identities = 36/120 (30%), Positives = 46/120 (38%), Gaps = 37/120 (30%)

Query: 590 TYMDCRAETSCDTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAK 649
           T   C+ E   D    A EE  I  SWFW   EA      NS S+  DK E  I      
Sbjct: 97  TSSTCKNEAGTDAWFWAGEEATI-NSWFWNGEEA-----GNSFSTKNDKPE--IGAQVCA 148

Query: 650 EEVSMKHGTGVRCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFW 709
           EE  ++   G  C+  +GAEE                           EEEE+++ +WFW
Sbjct: 149 EE--LEPAAGADCKPRSGAEE---------------------------EEEENVIGNWFW 179



 Score = 37.4 bits (85), Expect = 0.10
 Identities = 56/220 (25%), Positives = 81/220 (36%), Gaps = 35/220 (15%)

Query: 1   MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 60
           M G + ++ AQ K EKK   +   GA  E +   VVRP  +T+A+    A+ K  SK   
Sbjct: 1   MAGTKNKTRAQAKTEKKAAIQAKAGA--EREATGVVRPVAKTRAK----AKAKTGSKTDA 54

Query: 61  GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 120
            A  K  +     A  K  A + P +  K        P+ G E  S T +N         
Sbjct: 55  VAEMKAVSKNKVVAETKEGALSEPKTLGKAMGDF--TPKAGNESTSSTCKNE-------- 104

Query: 121 LVSTDSVLVAK-----TKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSW 175
              TD+   A        +     E  N    SF  +    + G Q      E    G+ 
Sbjct: 105 -AGTDAWFWAGEEATINSWFWNGEEAGN----SFSTKNDKPEIGAQVCAEELEPA-AGAD 158

Query: 176 CCPRPTSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHP 215
           C PR  +++E   N    W        FW GD+ +   +P
Sbjct: 159 CKPRSGAEEEEEENVIGNW--------FWEGDDTSFDPNP 190


>gi|216547663 basic helix-loop-helix domain containing, class B, 9
            [Homo sapiens]
          Length = 547

 Score =  236 bits (601), Expect = 1e-61
 Identities = 176/599 (29%), Positives = 299/599 (49%), Gaps = 67/599 (11%)

Query: 795  AETREEDRLAA--EKEGIVGSWFGAREET---IRREAGSCSKSSPKAEEEEVIIGSWFWE 849
            A T+ + R  A  EK+  + +  GA  E    +R  A + +K+  K   +   +      
Sbjct: 2    AGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVA----- 56

Query: 850  EEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESETEEETIFGS 909
             E    +   V  E+K G   E  T+G       + + +AG+   E   S  + E    +
Sbjct: 57   -EMKAVSKNKVVAETKEGALSEPKTLGKAMG---DFTPKAGN---ESTSSTCKNEAGTDA 109

Query: 910  WFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESKPENEEGAIV 969
            WFW G                  EE  + SWFW+ ++A     + +T   KPE      +
Sbjct: 110  WFWAG------------------EEATINSWFWNGEEA---GNSFSTKNDKPE------I 142

Query: 970  GSWFEAEDEVDNRTDNGSNCGSRTLADEDEA--IVGSWFWAGDEAHFESNPSPVFRAICR 1027
            G+   AE+        G++C  R+ A+E+E   ++G+WFW GD+  F+ NP PV R +  
Sbjct: 143  GAQVCAEEL---EPAAGADCKPRSGAEEEEEENVIGNWFWEGDDTSFDPNPKPVSRIVKP 199

Query: 1028 STCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRF--PKEAASLFCEMFGGK 1085
                   E +   RP+ W EVT+     P      P++  FR   P EA+     +    
Sbjct: 200  QPV---YEINEKNRPKDWSEVTIW----PNAPAVTPAVLGFRSQAPSEASPPSYIVLASA 252

Query: 1086 PRNMVLSPEG---EDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESSSC 1142
              N    P         +     QP PE  F  DP  +++ EIR  +R +E    +  +C
Sbjct: 253  EENACSLPVATACRPSRNTRSCSQPIPECRFDSDPCIQTIDEIRRQIRIREVNGIKPFAC 312

Query: 1143 NCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIE 1202
             C + E  + SEEFE+L+ L++   DP IH+I++IAMG+ +   F ++FI + GVV+LIE
Sbjct: 313  PC-KMECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQEFINEVGVVTLIE 371

Query: 1203 TLLNYPSSRVRTSFLENMIRMAPPYPN--LNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1260
            +LL++PS  +R    + +I + PP  +     I+ ++  +C+ET+++ ++SP Q SG+++
Sbjct: 372  SLLSFPSPEMRK---KTVITLNPPSGDERQRKIELHVKHMCKETMSFPLNSPGQQSGLKI 428

Query: 1261 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1320
            +  LTT   +H +VANY S    LL++GN KTR  VLK+LLN+SEN    +++++ +A++
Sbjct: 429  LGQLTTDFVHHYIVANYFSELFHLLSSGNCKTRNLVLKLLLNMSENPTAARDMINMKALA 488

Query: 1321 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKEL 1379
                +FN++E   N+   +AIF NI  +I+K ++   D  +   L++ F +V++  + +
Sbjct: 489  ALKLIFNQKEAKANLVSGVAIFINIKEHIRKGSIVVVDHLSYNTLMAIFREVKEIIETM 547



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 55/196 (28%), Positives = 86/196 (43%), Gaps = 17/196 (8%)

Query: 372 KKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADEASIESSLQVED 431
           K + RA+A T+++A  +A+A A++EA      +  T   A  ++    +A  E    V  
Sbjct: 5   KNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVAEMKA-VSK 63

Query: 432 ESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGA-REKTSMKTGAEATSESILA 490
             ++             T   + S P+T G+ +GD    A  E TS     EA +++   
Sbjct: 64  NKVVAE-----------TKEGALSEPKTLGKAMGDFTPKAGNESTSSTCKNEAGTDAWFW 112

Query: 491 ADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCESRTRSEEEE-- 548
           A +E  I  SWFW GEE       +         + A  +E   G  C+ R+ +EEEE  
Sbjct: 113 AGEEATI-NSWFWNGEEAGNSFSTKNDKPEIGAQVCAEELEPAAGADCKPRSGAEEEEEE 171

Query: 549 -VIGPWFWSGEQVDIE 563
            VIG WFW G+    +
Sbjct: 172 NVIGNWFWEGDDTSFD 187



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 57/204 (27%), Positives = 93/204 (45%), Gaps = 37/204 (18%)

Query: 323 AGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPEENANTFSRPMIKKEARARAMT- 381
           AG +   RA+ + +++A I    G+            E  A    RP+ K  A+A+A T 
Sbjct: 2   AGTKNKTRAQAKTEKKAAIQAKAGA------------EREATGVVRPVAKTRAKAKAKTG 49

Query: 382 ---------KEEAKTKARARAKQEARSEEEAL---IGTWF-WATDESSMA---DEASIES 425
                    K  +K K  A  K+ A SE + L   +G +   A +ES+ +   +EA  ++
Sbjct: 50  SKTDAVAEMKAVSKNKVVAETKEGALSEPKTLGKAMGDFTPKAGNESTSSTCKNEAGTDA 109

Query: 426 SLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTGAEATS 485
                +E+ I SWFW  EEA  G   S+K+    D   IG  +    E+     GA+   
Sbjct: 110 WFWAGEEATINSWFWNGEEA--GNSFSTKN----DKPEIGAQV--CAEELEPAAGADCKP 161

Query: 486 ESILAADDEQVIIGSWFWAGEEVN 509
            S    ++E+ +IG+WFW G++ +
Sbjct: 162 RSGAEEEEEENVIGNWFWEGDDTS 185



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 59/232 (25%), Positives = 93/232 (40%), Gaps = 40/232 (17%)

Query: 228 MANQEANTMSRSQTNQELYIASSSGSEDES--VKTPWFWARDKTNTWSGPREDPNSRSRF 285
           MA  +  T ++++T ++  I + +G+E E+  V  P    R K    +G + D  +  + 
Sbjct: 1   MAGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVAEMKA 60

Query: 286 RSKKEVYVESSSGSEHEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMP 345
            SK +V  E+  G+  E         GK A      +AG E+ +      K EA  D   
Sbjct: 61  VSKNKVVAETKEGALSEPKT-----LGK-AMGDFTPKAGNESTSST---CKNEAGTDAWF 111

Query: 346 GSIDVIKKESCFWP-EENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEAL 404
            + +     S FW  EE  N+FS    K E  A+    EE +  A A  K  + +EEE  
Sbjct: 112 WAGEEATINSWFWNGEEAGNSFSTKNDKPEIGAQVCA-EELEPAAGADCKPRSGAEEE-- 168

Query: 405 IGTWFWATDESSMADEASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSR 456
                                    E+E++IG+WFW  ++ S        SR
Sbjct: 169 -------------------------EEENVIGNWFWEGDDTSFDPNPKPVSR 195



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 31/108 (28%), Positives = 48/108 (44%), Gaps = 10/108 (9%)

Query: 687 PAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAIIGSWLWATEESNIDGTGEKAKLLTEEE 746
           P  G    S   + E   ++WFW+ +    EA I SW W  EE+     G       ++ 
Sbjct: 90  PKAGNESTSSTCKNEAGTDAWFWAGE----EATINSWFWNGEEA-----GNSFSTKNDKP 140

Query: 747 TIINSWFWKEDEAISEATDREESRPEAEEGD-IIGSWFWAGEEDRLEP 793
            I      +E E  + A  +  S  E EE + +IG+WFW G++   +P
Sbjct: 141 EIGAQVCAEELEPAAGADCKPRSGAEEEEEENVIGNWFWEGDDTSFDP 188



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 57/251 (22%), Positives = 96/251 (38%), Gaps = 57/251 (22%)

Query: 50  ARPKNKSKVMPGASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTE 109
           A  KNK++       K    A  GA  ++     PV++ + +A              K +
Sbjct: 2   AGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKA--------------KAK 47

Query: 110 RNSQTNIIASPLVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEE 169
             S+T+ +A      +   V+K K ++E +E       S P+        F P   ++  
Sbjct: 48  TGSKTDAVA------EMKAVSKNKVVAETKE----GALSEPKTLGKAMGDFTPKAGNEST 97

Query: 170 TNMGSWCCPRPTSKQEASPNSDFKWV--DKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMH 227
           ++         T K EA  ++ F W   + +++S FW+G+E    F   N   +    + 
Sbjct: 98  SS---------TCKNEAGTDAWF-WAGEEATINSWFWNGEEAGNSFSTKNDKPEIGAQVC 147

Query: 228 MANQE----ANTMSRSQTNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSR- 282
               E    A+   RS   +E         E+E+V   WFW  D T+       DPN + 
Sbjct: 148 AEELEPAAGADCKPRSGAEEE---------EEENVIGNWFWEGDDTSF------DPNPKP 192

Query: 283 -SRFRSKKEVY 292
            SR    + VY
Sbjct: 193 VSRIVKPQPVY 203



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 16/99 (16%)

Query: 684 CMYPAGGGSWKSRPEEEEDIVNSWFW---------SRKYTKPEAIIGSWLWATEESNIDG 734
           C   AG  +W    EE    +NSWFW         S K  KPE  IG+ + A E     G
Sbjct: 101 CKNEAGTDAWFWAGEEAT--INSWFWNGEEAGNSFSTKNDKPE--IGAQVCAEELEPAAG 156

Query: 735 TGEKAKLLTEEE---TIINSWFWKEDEAISEATDREESR 770
              K +   EEE    +I +WFW+ D+   +   +  SR
Sbjct: 157 ADCKPRSGAEEEEEENVIGNWFWEGDDTSFDPNPKPVSR 195



 Score = 38.5 bits (88), Expect = 0.046
 Identities = 36/120 (30%), Positives = 46/120 (38%), Gaps = 37/120 (30%)

Query: 590 TYMDCRAETSCDTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAK 649
           T   C+ E   D    A EE  I  SWFW   EA      NS S+  DK E  I      
Sbjct: 97  TSSTCKNEAGTDAWFWAGEEATI-NSWFWNGEEA-----GNSFSTKNDKPE--IGAQVCA 148

Query: 650 EEVSMKHGTGVRCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFW 709
           EE  ++   G  C+  +GAEE                           EEEE+++ +WFW
Sbjct: 149 EE--LEPAAGADCKPRSGAEE---------------------------EEEENVIGNWFW 179



 Score = 37.4 bits (85), Expect = 0.10
 Identities = 56/220 (25%), Positives = 81/220 (36%), Gaps = 35/220 (15%)

Query: 1   MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 60
           M G + ++ AQ K EKK   +   GA  E +   VVRP  +T+A+    A+ K  SK   
Sbjct: 1   MAGTKNKTRAQAKTEKKAAIQAKAGA--EREATGVVRPVAKTRAK----AKAKTGSKTDA 54

Query: 61  GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 120
            A  K  +     A  K  A + P +  K        P+ G E  S T +N         
Sbjct: 55  VAEMKAVSKNKVVAETKEGALSEPKTLGKAMGDF--TPKAGNESTSSTCKNE-------- 104

Query: 121 LVSTDSVLVAK-----TKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSW 175
              TD+   A        +     E  N    SF  +    + G Q      E    G+ 
Sbjct: 105 -AGTDAWFWAGEEATINSWFWNGEEAGN----SFSTKNDKPEIGAQVCAEELEPA-AGAD 158

Query: 176 CCPRPTSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHP 215
           C PR  +++E   N    W        FW GD+ +   +P
Sbjct: 159 CKPRSGAEEEEEENVIGNW--------FWEGDDTSFDPNP 190


>gi|216547655 basic helix-loop-helix domain containing, class B, 9
            [Homo sapiens]
          Length = 547

 Score =  236 bits (601), Expect = 1e-61
 Identities = 176/599 (29%), Positives = 299/599 (49%), Gaps = 67/599 (11%)

Query: 795  AETREEDRLAA--EKEGIVGSWFGAREET---IRREAGSCSKSSPKAEEEEVIIGSWFWE 849
            A T+ + R  A  EK+  + +  GA  E    +R  A + +K+  K   +   +      
Sbjct: 2    AGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVA----- 56

Query: 850  EEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESETEEETIFGS 909
             E    +   V  E+K G   E  T+G       + + +AG+   E   S  + E    +
Sbjct: 57   -EMKAVSKNKVVAETKEGALSEPKTLGKAMG---DFTPKAGN---ESTSSTCKNEAGTDA 109

Query: 910  WFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESKPENEEGAIV 969
            WFW G                  EE  + SWFW+ ++A     + +T   KPE      +
Sbjct: 110  WFWAG------------------EEATINSWFWNGEEA---GNSFSTKNDKPE------I 142

Query: 970  GSWFEAEDEVDNRTDNGSNCGSRTLADEDEA--IVGSWFWAGDEAHFESNPSPVFRAICR 1027
            G+   AE+        G++C  R+ A+E+E   ++G+WFW GD+  F+ NP PV R +  
Sbjct: 143  GAQVCAEEL---EPAAGADCKPRSGAEEEEEENVIGNWFWEGDDTSFDPNPKPVSRIVKP 199

Query: 1028 STCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRF--PKEAASLFCEMFGGK 1085
                   E +   RP+ W EVT+     P      P++  FR   P EA+     +    
Sbjct: 200  QPV---YEINEKNRPKDWSEVTIW----PNAPAVTPAVLGFRSQAPSEASPPSYIVLASA 252

Query: 1086 PRNMVLSPEG---EDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESSSC 1142
              N    P         +     QP PE  F  DP  +++ EIR  +R +E    +  +C
Sbjct: 253  EENACSLPVATACRPSRNTRSCSQPIPECRFDSDPCIQTIDEIRRQIRIREVNGIKPFAC 312

Query: 1143 NCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIE 1202
             C + E  + SEEFE+L+ L++   DP IH+I++IAMG+ +   F ++FI + GVV+LIE
Sbjct: 313  PC-KMECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQEFINEVGVVTLIE 371

Query: 1203 TLLNYPSSRVRTSFLENMIRMAPPYPN--LNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1260
            +LL++PS  +R    + +I + PP  +     I+ ++  +C+ET+++ ++SP Q SG+++
Sbjct: 372  SLLSFPSPEMRK---KTVITLNPPSGDERQRKIELHVKHMCKETMSFPLNSPGQQSGLKI 428

Query: 1261 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1320
            +  LTT   +H +VANY S    LL++GN KTR  VLK+LLN+SEN    +++++ +A++
Sbjct: 429  LGQLTTDFVHHYIVANYFSELFHLLSSGNCKTRNLVLKLLLNMSENPTAARDMINMKALA 488

Query: 1321 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKEL 1379
                +FN++E   N+   +AIF NI  +I+K ++   D  +   L++ F +V++  + +
Sbjct: 489  ALKLIFNQKEAKANLVSGVAIFINIKEHIRKGSIVVVDHLSYNTLMAIFREVKEIIETM 547



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 55/196 (28%), Positives = 86/196 (43%), Gaps = 17/196 (8%)

Query: 372 KKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADEASIESSLQVED 431
           K + RA+A T+++A  +A+A A++EA      +  T   A  ++    +A  E    V  
Sbjct: 5   KNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVAEMKA-VSK 63

Query: 432 ESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGA-REKTSMKTGAEATSESILA 490
             ++             T   + S P+T G+ +GD    A  E TS     EA +++   
Sbjct: 64  NKVVAE-----------TKEGALSEPKTLGKAMGDFTPKAGNESTSSTCKNEAGTDAWFW 112

Query: 491 ADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCESRTRSEEEE-- 548
           A +E  I  SWFW GEE       +         + A  +E   G  C+ R+ +EEEE  
Sbjct: 113 AGEEATI-NSWFWNGEEAGNSFSTKNDKPEIGAQVCAEELEPAAGADCKPRSGAEEEEEE 171

Query: 549 -VIGPWFWSGEQVDIE 563
            VIG WFW G+    +
Sbjct: 172 NVIGNWFWEGDDTSFD 187



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 57/204 (27%), Positives = 93/204 (45%), Gaps = 37/204 (18%)

Query: 323 AGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPEENANTFSRPMIKKEARARAMT- 381
           AG +   RA+ + +++A I    G+            E  A    RP+ K  A+A+A T 
Sbjct: 2   AGTKNKTRAQAKTEKKAAIQAKAGA------------EREATGVVRPVAKTRAKAKAKTG 49

Query: 382 ---------KEEAKTKARARAKQEARSEEEAL---IGTWF-WATDESSMA---DEASIES 425
                    K  +K K  A  K+ A SE + L   +G +   A +ES+ +   +EA  ++
Sbjct: 50  SKTDAVAEMKAVSKNKVVAETKEGALSEPKTLGKAMGDFTPKAGNESTSSTCKNEAGTDA 109

Query: 426 SLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTGAEATS 485
                +E+ I SWFW  EEA  G   S+K+    D   IG  +    E+     GA+   
Sbjct: 110 WFWAGEEATINSWFWNGEEA--GNSFSTKN----DKPEIGAQV--CAEELEPAAGADCKP 161

Query: 486 ESILAADDEQVIIGSWFWAGEEVN 509
            S    ++E+ +IG+WFW G++ +
Sbjct: 162 RSGAEEEEEENVIGNWFWEGDDTS 185



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 59/232 (25%), Positives = 93/232 (40%), Gaps = 40/232 (17%)

Query: 228 MANQEANTMSRSQTNQELYIASSSGSEDES--VKTPWFWARDKTNTWSGPREDPNSRSRF 285
           MA  +  T ++++T ++  I + +G+E E+  V  P    R K    +G + D  +  + 
Sbjct: 1   MAGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVAEMKA 60

Query: 286 RSKKEVYVESSSGSEHEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMP 345
            SK +V  E+  G+  E         GK A      +AG E+ +      K EA  D   
Sbjct: 61  VSKNKVVAETKEGALSEPKT-----LGK-AMGDFTPKAGNESTSST---CKNEAGTDAWF 111

Query: 346 GSIDVIKKESCFWP-EENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEAL 404
            + +     S FW  EE  N+FS    K E  A+    EE +  A A  K  + +EEE  
Sbjct: 112 WAGEEATINSWFWNGEEAGNSFSTKNDKPEIGAQVCA-EELEPAAGADCKPRSGAEEE-- 168

Query: 405 IGTWFWATDESSMADEASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSR 456
                                    E+E++IG+WFW  ++ S        SR
Sbjct: 169 -------------------------EEENVIGNWFWEGDDTSFDPNPKPVSR 195



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 31/108 (28%), Positives = 48/108 (44%), Gaps = 10/108 (9%)

Query: 687 PAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAIIGSWLWATEESNIDGTGEKAKLLTEEE 746
           P  G    S   + E   ++WFW+ +    EA I SW W  EE+     G       ++ 
Sbjct: 90  PKAGNESTSSTCKNEAGTDAWFWAGE----EATINSWFWNGEEA-----GNSFSTKNDKP 140

Query: 747 TIINSWFWKEDEAISEATDREESRPEAEEGD-IIGSWFWAGEEDRLEP 793
            I      +E E  + A  +  S  E EE + +IG+WFW G++   +P
Sbjct: 141 EIGAQVCAEELEPAAGADCKPRSGAEEEEEENVIGNWFWEGDDTSFDP 188



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 57/251 (22%), Positives = 96/251 (38%), Gaps = 57/251 (22%)

Query: 50  ARPKNKSKVMPGASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTE 109
           A  KNK++       K    A  GA  ++     PV++ + +A              K +
Sbjct: 2   AGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKA--------------KAK 47

Query: 110 RNSQTNIIASPLVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEE 169
             S+T+ +A      +   V+K K ++E +E       S P+        F P   ++  
Sbjct: 48  TGSKTDAVA------EMKAVSKNKVVAETKE----GALSEPKTLGKAMGDFTPKAGNEST 97

Query: 170 TNMGSWCCPRPTSKQEASPNSDFKWV--DKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMH 227
           ++         T K EA  ++ F W   + +++S FW+G+E    F   N   +    + 
Sbjct: 98  SS---------TCKNEAGTDAWF-WAGEEATINSWFWNGEEAGNSFSTKNDKPEIGAQVC 147

Query: 228 MANQE----ANTMSRSQTNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSR- 282
               E    A+   RS   +E         E+E+V   WFW  D T+       DPN + 
Sbjct: 148 AEELEPAAGADCKPRSGAEEE---------EEENVIGNWFWEGDDTSF------DPNPKP 192

Query: 283 -SRFRSKKEVY 292
            SR    + VY
Sbjct: 193 VSRIVKPQPVY 203



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 16/99 (16%)

Query: 684 CMYPAGGGSWKSRPEEEEDIVNSWFW---------SRKYTKPEAIIGSWLWATEESNIDG 734
           C   AG  +W    EE    +NSWFW         S K  KPE  IG+ + A E     G
Sbjct: 101 CKNEAGTDAWFWAGEEAT--INSWFWNGEEAGNSFSTKNDKPE--IGAQVCAEELEPAAG 156

Query: 735 TGEKAKLLTEEE---TIINSWFWKEDEAISEATDREESR 770
              K +   EEE    +I +WFW+ D+   +   +  SR
Sbjct: 157 ADCKPRSGAEEEEEENVIGNWFWEGDDTSFDPNPKPVSR 195



 Score = 38.5 bits (88), Expect = 0.046
 Identities = 36/120 (30%), Positives = 46/120 (38%), Gaps = 37/120 (30%)

Query: 590 TYMDCRAETSCDTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAK 649
           T   C+ E   D    A EE  I  SWFW   EA      NS S+  DK E  I      
Sbjct: 97  TSSTCKNEAGTDAWFWAGEEATI-NSWFWNGEEA-----GNSFSTKNDKPE--IGAQVCA 148

Query: 650 EEVSMKHGTGVRCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFW 709
           EE  ++   G  C+  +GAEE                           EEEE+++ +WFW
Sbjct: 149 EE--LEPAAGADCKPRSGAEE---------------------------EEEENVIGNWFW 179



 Score = 37.4 bits (85), Expect = 0.10
 Identities = 56/220 (25%), Positives = 81/220 (36%), Gaps = 35/220 (15%)

Query: 1   MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 60
           M G + ++ AQ K EKK   +   GA  E +   VVRP  +T+A+    A+ K  SK   
Sbjct: 1   MAGTKNKTRAQAKTEKKAAIQAKAGA--EREATGVVRPVAKTRAK----AKAKTGSKTDA 54

Query: 61  GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 120
            A  K  +     A  K  A + P +  K        P+ G E  S T +N         
Sbjct: 55  VAEMKAVSKNKVVAETKEGALSEPKTLGKAMGDF--TPKAGNESTSSTCKNE-------- 104

Query: 121 LVSTDSVLVAK-----TKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSW 175
              TD+   A        +     E  N    SF  +    + G Q      E    G+ 
Sbjct: 105 -AGTDAWFWAGEEATINSWFWNGEEAGN----SFSTKNDKPEIGAQVCAEELEPA-AGAD 158

Query: 176 CCPRPTSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHP 215
           C PR  +++E   N    W        FW GD+ +   +P
Sbjct: 159 CKPRSGAEEEEEENVIGNW--------FWEGDDTSFDPNP 190


>gi|216547646 basic helix-loop-helix domain containing, class B, 9
            [Homo sapiens]
          Length = 547

 Score =  236 bits (601), Expect = 1e-61
 Identities = 176/599 (29%), Positives = 299/599 (49%), Gaps = 67/599 (11%)

Query: 795  AETREEDRLAA--EKEGIVGSWFGAREET---IRREAGSCSKSSPKAEEEEVIIGSWFWE 849
            A T+ + R  A  EK+  + +  GA  E    +R  A + +K+  K   +   +      
Sbjct: 2    AGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVA----- 56

Query: 850  EEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESETEEETIFGS 909
             E    +   V  E+K G   E  T+G       + + +AG+   E   S  + E    +
Sbjct: 57   -EMKAVSKNKVVAETKEGALSEPKTLGKAMG---DFTPKAGN---ESTSSTCKNEAGTDA 109

Query: 910  WFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESKPENEEGAIV 969
            WFW G                  EE  + SWFW+ ++A     + +T   KPE      +
Sbjct: 110  WFWAG------------------EEATINSWFWNGEEA---GNSFSTKNDKPE------I 142

Query: 970  GSWFEAEDEVDNRTDNGSNCGSRTLADEDEA--IVGSWFWAGDEAHFESNPSPVFRAICR 1027
            G+   AE+        G++C  R+ A+E+E   ++G+WFW GD+  F+ NP PV R +  
Sbjct: 143  GAQVCAEEL---EPAAGADCKPRSGAEEEEEENVIGNWFWEGDDTSFDPNPKPVSRIVKP 199

Query: 1028 STCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRF--PKEAASLFCEMFGGK 1085
                   E +   RP+ W EVT+     P      P++  FR   P EA+     +    
Sbjct: 200  QPV---YEINEKNRPKDWSEVTIW----PNAPAVTPAVLGFRSQAPSEASPPSYIVLASA 252

Query: 1086 PRNMVLSPEG---EDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESSSC 1142
              N    P         +     QP PE  F  DP  +++ EIR  +R +E    +  +C
Sbjct: 253  EENACSLPVATACRPSRNTRSCSQPIPECRFDSDPCIQTIDEIRRQIRIREVNGIKPFAC 312

Query: 1143 NCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIE 1202
             C + E  + SEEFE+L+ L++   DP IH+I++IAMG+ +   F ++FI + GVV+LIE
Sbjct: 313  PC-KMECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQEFINEVGVVTLIE 371

Query: 1203 TLLNYPSSRVRTSFLENMIRMAPPYPN--LNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1260
            +LL++PS  +R    + +I + PP  +     I+ ++  +C+ET+++ ++SP Q SG+++
Sbjct: 372  SLLSFPSPEMRK---KTVITLNPPSGDERQRKIELHVKHMCKETMSFPLNSPGQQSGLKI 428

Query: 1261 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1320
            +  LTT   +H +VANY S    LL++GN KTR  VLK+LLN+SEN    +++++ +A++
Sbjct: 429  LGQLTTDFVHHYIVANYFSELFHLLSSGNCKTRNLVLKLLLNMSENPTAARDMINMKALA 488

Query: 1321 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKEL 1379
                +FN++E   N+   +AIF NI  +I+K ++   D  +   L++ F +V++  + +
Sbjct: 489  ALKLIFNQKEAKANLVSGVAIFINIKEHIRKGSIVVVDHLSYNTLMAIFREVKEIIETM 547



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 55/196 (28%), Positives = 86/196 (43%), Gaps = 17/196 (8%)

Query: 372 KKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADEASIESSLQVED 431
           K + RA+A T+++A  +A+A A++EA      +  T   A  ++    +A  E    V  
Sbjct: 5   KNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVAEMKA-VSK 63

Query: 432 ESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGA-REKTSMKTGAEATSESILA 490
             ++             T   + S P+T G+ +GD    A  E TS     EA +++   
Sbjct: 64  NKVVAE-----------TKEGALSEPKTLGKAMGDFTPKAGNESTSSTCKNEAGTDAWFW 112

Query: 491 ADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCESRTRSEEEE-- 548
           A +E  I  SWFW GEE       +         + A  +E   G  C+ R+ +EEEE  
Sbjct: 113 AGEEATI-NSWFWNGEEAGNSFSTKNDKPEIGAQVCAEELEPAAGADCKPRSGAEEEEEE 171

Query: 549 -VIGPWFWSGEQVDIE 563
            VIG WFW G+    +
Sbjct: 172 NVIGNWFWEGDDTSFD 187



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 57/204 (27%), Positives = 93/204 (45%), Gaps = 37/204 (18%)

Query: 323 AGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPEENANTFSRPMIKKEARARAMT- 381
           AG +   RA+ + +++A I    G+            E  A    RP+ K  A+A+A T 
Sbjct: 2   AGTKNKTRAQAKTEKKAAIQAKAGA------------EREATGVVRPVAKTRAKAKAKTG 49

Query: 382 ---------KEEAKTKARARAKQEARSEEEAL---IGTWF-WATDESSMA---DEASIES 425
                    K  +K K  A  K+ A SE + L   +G +   A +ES+ +   +EA  ++
Sbjct: 50  SKTDAVAEMKAVSKNKVVAETKEGALSEPKTLGKAMGDFTPKAGNESTSSTCKNEAGTDA 109

Query: 426 SLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTGAEATS 485
                +E+ I SWFW  EEA  G   S+K+    D   IG  +    E+     GA+   
Sbjct: 110 WFWAGEEATINSWFWNGEEA--GNSFSTKN----DKPEIGAQV--CAEELEPAAGADCKP 161

Query: 486 ESILAADDEQVIIGSWFWAGEEVN 509
            S    ++E+ +IG+WFW G++ +
Sbjct: 162 RSGAEEEEEENVIGNWFWEGDDTS 185



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 59/232 (25%), Positives = 93/232 (40%), Gaps = 40/232 (17%)

Query: 228 MANQEANTMSRSQTNQELYIASSSGSEDES--VKTPWFWARDKTNTWSGPREDPNSRSRF 285
           MA  +  T ++++T ++  I + +G+E E+  V  P    R K    +G + D  +  + 
Sbjct: 1   MAGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVAEMKA 60

Query: 286 RSKKEVYVESSSGSEHEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMP 345
            SK +V  E+  G+  E         GK A      +AG E+ +      K EA  D   
Sbjct: 61  VSKNKVVAETKEGALSEPKT-----LGK-AMGDFTPKAGNESTSST---CKNEAGTDAWF 111

Query: 346 GSIDVIKKESCFWP-EENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEAL 404
            + +     S FW  EE  N+FS    K E  A+    EE +  A A  K  + +EEE  
Sbjct: 112 WAGEEATINSWFWNGEEAGNSFSTKNDKPEIGAQVCA-EELEPAAGADCKPRSGAEEE-- 168

Query: 405 IGTWFWATDESSMADEASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSR 456
                                    E+E++IG+WFW  ++ S        SR
Sbjct: 169 -------------------------EEENVIGNWFWEGDDTSFDPNPKPVSR 195



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 31/108 (28%), Positives = 48/108 (44%), Gaps = 10/108 (9%)

Query: 687 PAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAIIGSWLWATEESNIDGTGEKAKLLTEEE 746
           P  G    S   + E   ++WFW+ +    EA I SW W  EE+     G       ++ 
Sbjct: 90  PKAGNESTSSTCKNEAGTDAWFWAGE----EATINSWFWNGEEA-----GNSFSTKNDKP 140

Query: 747 TIINSWFWKEDEAISEATDREESRPEAEEGD-IIGSWFWAGEEDRLEP 793
            I      +E E  + A  +  S  E EE + +IG+WFW G++   +P
Sbjct: 141 EIGAQVCAEELEPAAGADCKPRSGAEEEEEENVIGNWFWEGDDTSFDP 188



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 57/251 (22%), Positives = 96/251 (38%), Gaps = 57/251 (22%)

Query: 50  ARPKNKSKVMPGASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTE 109
           A  KNK++       K    A  GA  ++     PV++ + +A              K +
Sbjct: 2   AGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKA--------------KAK 47

Query: 110 RNSQTNIIASPLVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEE 169
             S+T+ +A      +   V+K K ++E +E       S P+        F P   ++  
Sbjct: 48  TGSKTDAVA------EMKAVSKNKVVAETKE----GALSEPKTLGKAMGDFTPKAGNEST 97

Query: 170 TNMGSWCCPRPTSKQEASPNSDFKWV--DKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMH 227
           ++         T K EA  ++ F W   + +++S FW+G+E    F   N   +    + 
Sbjct: 98  SS---------TCKNEAGTDAWF-WAGEEATINSWFWNGEEAGNSFSTKNDKPEIGAQVC 147

Query: 228 MANQE----ANTMSRSQTNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSR- 282
               E    A+   RS   +E         E+E+V   WFW  D T+       DPN + 
Sbjct: 148 AEELEPAAGADCKPRSGAEEE---------EEENVIGNWFWEGDDTSF------DPNPKP 192

Query: 283 -SRFRSKKEVY 292
            SR    + VY
Sbjct: 193 VSRIVKPQPVY 203



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 16/99 (16%)

Query: 684 CMYPAGGGSWKSRPEEEEDIVNSWFW---------SRKYTKPEAIIGSWLWATEESNIDG 734
           C   AG  +W    EE    +NSWFW         S K  KPE  IG+ + A E     G
Sbjct: 101 CKNEAGTDAWFWAGEEAT--INSWFWNGEEAGNSFSTKNDKPE--IGAQVCAEELEPAAG 156

Query: 735 TGEKAKLLTEEE---TIINSWFWKEDEAISEATDREESR 770
              K +   EEE    +I +WFW+ D+   +   +  SR
Sbjct: 157 ADCKPRSGAEEEEEENVIGNWFWEGDDTSFDPNPKPVSR 195



 Score = 38.5 bits (88), Expect = 0.046
 Identities = 36/120 (30%), Positives = 46/120 (38%), Gaps = 37/120 (30%)

Query: 590 TYMDCRAETSCDTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAK 649
           T   C+ E   D    A EE  I  SWFW   EA      NS S+  DK E  I      
Sbjct: 97  TSSTCKNEAGTDAWFWAGEEATI-NSWFWNGEEA-----GNSFSTKNDKPE--IGAQVCA 148

Query: 650 EEVSMKHGTGVRCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFW 709
           EE  ++   G  C+  +GAEE                           EEEE+++ +WFW
Sbjct: 149 EE--LEPAAGADCKPRSGAEE---------------------------EEEENVIGNWFW 179



 Score = 37.4 bits (85), Expect = 0.10
 Identities = 56/220 (25%), Positives = 81/220 (36%), Gaps = 35/220 (15%)

Query: 1   MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 60
           M G + ++ AQ K EKK   +   GA  E +   VVRP  +T+A+    A+ K  SK   
Sbjct: 1   MAGTKNKTRAQAKTEKKAAIQAKAGA--EREATGVVRPVAKTRAK----AKAKTGSKTDA 54

Query: 61  GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 120
            A  K  +     A  K  A + P +  K        P+ G E  S T +N         
Sbjct: 55  VAEMKAVSKNKVVAETKEGALSEPKTLGKAMGDF--TPKAGNESTSSTCKNE-------- 104

Query: 121 LVSTDSVLVAK-----TKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSW 175
              TD+   A        +     E  N    SF  +    + G Q      E    G+ 
Sbjct: 105 -AGTDAWFWAGEEATINSWFWNGEEAGN----SFSTKNDKPEIGAQVCAEELEPA-AGAD 158

Query: 176 CCPRPTSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHP 215
           C PR  +++E   N    W        FW GD+ +   +P
Sbjct: 159 CKPRSGAEEEEEENVIGNW--------FWEGDDTSFDPNP 190


>gi|216547639 basic helix-loop-helix domain containing, class B, 9
            [Homo sapiens]
          Length = 547

 Score =  236 bits (601), Expect = 1e-61
 Identities = 176/599 (29%), Positives = 299/599 (49%), Gaps = 67/599 (11%)

Query: 795  AETREEDRLAA--EKEGIVGSWFGAREET---IRREAGSCSKSSPKAEEEEVIIGSWFWE 849
            A T+ + R  A  EK+  + +  GA  E    +R  A + +K+  K   +   +      
Sbjct: 2    AGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVA----- 56

Query: 850  EEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESETEEETIFGS 909
             E    +   V  E+K G   E  T+G       + + +AG+   E   S  + E    +
Sbjct: 57   -EMKAVSKNKVVAETKEGALSEPKTLGKAMG---DFTPKAGN---ESTSSTCKNEAGTDA 109

Query: 910  WFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESKPENEEGAIV 969
            WFW G                  EE  + SWFW+ ++A     + +T   KPE      +
Sbjct: 110  WFWAG------------------EEATINSWFWNGEEA---GNSFSTKNDKPE------I 142

Query: 970  GSWFEAEDEVDNRTDNGSNCGSRTLADEDEA--IVGSWFWAGDEAHFESNPSPVFRAICR 1027
            G+   AE+        G++C  R+ A+E+E   ++G+WFW GD+  F+ NP PV R +  
Sbjct: 143  GAQVCAEEL---EPAAGADCKPRSGAEEEEEENVIGNWFWEGDDTSFDPNPKPVSRIVKP 199

Query: 1028 STCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRF--PKEAASLFCEMFGGK 1085
                   E +   RP+ W EVT+     P      P++  FR   P EA+     +    
Sbjct: 200  QPV---YEINEKNRPKDWSEVTIW----PNAPAVTPAVLGFRSQAPSEASPPSYIVLASA 252

Query: 1086 PRNMVLSPEG---EDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESSSC 1142
              N    P         +     QP PE  F  DP  +++ EIR  +R +E    +  +C
Sbjct: 253  EENACSLPVATACRPSRNTRSCSQPIPECRFDSDPCIQTIDEIRRQIRIREVNGIKPFAC 312

Query: 1143 NCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIE 1202
             C + E  + SEEFE+L+ L++   DP IH+I++IAMG+ +   F ++FI + GVV+LIE
Sbjct: 313  PC-KMECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQEFINEVGVVTLIE 371

Query: 1203 TLLNYPSSRVRTSFLENMIRMAPPYPN--LNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1260
            +LL++PS  +R    + +I + PP  +     I+ ++  +C+ET+++ ++SP Q SG+++
Sbjct: 372  SLLSFPSPEMRK---KTVITLNPPSGDERQRKIELHVKHMCKETMSFPLNSPGQQSGLKI 428

Query: 1261 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1320
            +  LTT   +H +VANY S    LL++GN KTR  VLK+LLN+SEN    +++++ +A++
Sbjct: 429  LGQLTTDFVHHYIVANYFSELFHLLSSGNCKTRNLVLKLLLNMSENPTAARDMINMKALA 488

Query: 1321 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKEL 1379
                +FN++E   N+   +AIF NI  +I+K ++   D  +   L++ F +V++  + +
Sbjct: 489  ALKLIFNQKEAKANLVSGVAIFINIKEHIRKGSIVVVDHLSYNTLMAIFREVKEIIETM 547



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 55/196 (28%), Positives = 86/196 (43%), Gaps = 17/196 (8%)

Query: 372 KKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADEASIESSLQVED 431
           K + RA+A T+++A  +A+A A++EA      +  T   A  ++    +A  E    V  
Sbjct: 5   KNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVAEMKA-VSK 63

Query: 432 ESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGA-REKTSMKTGAEATSESILA 490
             ++             T   + S P+T G+ +GD    A  E TS     EA +++   
Sbjct: 64  NKVVAE-----------TKEGALSEPKTLGKAMGDFTPKAGNESTSSTCKNEAGTDAWFW 112

Query: 491 ADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCESRTRSEEEE-- 548
           A +E  I  SWFW GEE       +         + A  +E   G  C+ R+ +EEEE  
Sbjct: 113 AGEEATI-NSWFWNGEEAGNSFSTKNDKPEIGAQVCAEELEPAAGADCKPRSGAEEEEEE 171

Query: 549 -VIGPWFWSGEQVDIE 563
            VIG WFW G+    +
Sbjct: 172 NVIGNWFWEGDDTSFD 187



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 57/204 (27%), Positives = 93/204 (45%), Gaps = 37/204 (18%)

Query: 323 AGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPEENANTFSRPMIKKEARARAMT- 381
           AG +   RA+ + +++A I    G+            E  A    RP+ K  A+A+A T 
Sbjct: 2   AGTKNKTRAQAKTEKKAAIQAKAGA------------EREATGVVRPVAKTRAKAKAKTG 49

Query: 382 ---------KEEAKTKARARAKQEARSEEEAL---IGTWF-WATDESSMA---DEASIES 425
                    K  +K K  A  K+ A SE + L   +G +   A +ES+ +   +EA  ++
Sbjct: 50  SKTDAVAEMKAVSKNKVVAETKEGALSEPKTLGKAMGDFTPKAGNESTSSTCKNEAGTDA 109

Query: 426 SLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTGAEATS 485
                +E+ I SWFW  EEA  G   S+K+    D   IG  +    E+     GA+   
Sbjct: 110 WFWAGEEATINSWFWNGEEA--GNSFSTKN----DKPEIGAQV--CAEELEPAAGADCKP 161

Query: 486 ESILAADDEQVIIGSWFWAGEEVN 509
            S    ++E+ +IG+WFW G++ +
Sbjct: 162 RSGAEEEEEENVIGNWFWEGDDTS 185



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 59/232 (25%), Positives = 93/232 (40%), Gaps = 40/232 (17%)

Query: 228 MANQEANTMSRSQTNQELYIASSSGSEDES--VKTPWFWARDKTNTWSGPREDPNSRSRF 285
           MA  +  T ++++T ++  I + +G+E E+  V  P    R K    +G + D  +  + 
Sbjct: 1   MAGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVAEMKA 60

Query: 286 RSKKEVYVESSSGSEHEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMP 345
            SK +V  E+  G+  E         GK A      +AG E+ +      K EA  D   
Sbjct: 61  VSKNKVVAETKEGALSEPKT-----LGK-AMGDFTPKAGNESTSST---CKNEAGTDAWF 111

Query: 346 GSIDVIKKESCFWP-EENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEAL 404
            + +     S FW  EE  N+FS    K E  A+    EE +  A A  K  + +EEE  
Sbjct: 112 WAGEEATINSWFWNGEEAGNSFSTKNDKPEIGAQVCA-EELEPAAGADCKPRSGAEEE-- 168

Query: 405 IGTWFWATDESSMADEASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSR 456
                                    E+E++IG+WFW  ++ S        SR
Sbjct: 169 -------------------------EEENVIGNWFWEGDDTSFDPNPKPVSR 195



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 31/108 (28%), Positives = 48/108 (44%), Gaps = 10/108 (9%)

Query: 687 PAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAIIGSWLWATEESNIDGTGEKAKLLTEEE 746
           P  G    S   + E   ++WFW+ +    EA I SW W  EE+     G       ++ 
Sbjct: 90  PKAGNESTSSTCKNEAGTDAWFWAGE----EATINSWFWNGEEA-----GNSFSTKNDKP 140

Query: 747 TIINSWFWKEDEAISEATDREESRPEAEEGD-IIGSWFWAGEEDRLEP 793
            I      +E E  + A  +  S  E EE + +IG+WFW G++   +P
Sbjct: 141 EIGAQVCAEELEPAAGADCKPRSGAEEEEEENVIGNWFWEGDDTSFDP 188



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 57/251 (22%), Positives = 96/251 (38%), Gaps = 57/251 (22%)

Query: 50  ARPKNKSKVMPGASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTE 109
           A  KNK++       K    A  GA  ++     PV++ + +A              K +
Sbjct: 2   AGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKA--------------KAK 47

Query: 110 RNSQTNIIASPLVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEE 169
             S+T+ +A      +   V+K K ++E +E       S P+        F P   ++  
Sbjct: 48  TGSKTDAVA------EMKAVSKNKVVAETKE----GALSEPKTLGKAMGDFTPKAGNEST 97

Query: 170 TNMGSWCCPRPTSKQEASPNSDFKWV--DKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMH 227
           ++         T K EA  ++ F W   + +++S FW+G+E    F   N   +    + 
Sbjct: 98  SS---------TCKNEAGTDAWF-WAGEEATINSWFWNGEEAGNSFSTKNDKPEIGAQVC 147

Query: 228 MANQE----ANTMSRSQTNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSR- 282
               E    A+   RS   +E         E+E+V   WFW  D T+       DPN + 
Sbjct: 148 AEELEPAAGADCKPRSGAEEE---------EEENVIGNWFWEGDDTSF------DPNPKP 192

Query: 283 -SRFRSKKEVY 292
            SR    + VY
Sbjct: 193 VSRIVKPQPVY 203



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 16/99 (16%)

Query: 684 CMYPAGGGSWKSRPEEEEDIVNSWFW---------SRKYTKPEAIIGSWLWATEESNIDG 734
           C   AG  +W    EE    +NSWFW         S K  KPE  IG+ + A E     G
Sbjct: 101 CKNEAGTDAWFWAGEEAT--INSWFWNGEEAGNSFSTKNDKPE--IGAQVCAEELEPAAG 156

Query: 735 TGEKAKLLTEEE---TIINSWFWKEDEAISEATDREESR 770
              K +   EEE    +I +WFW+ D+   +   +  SR
Sbjct: 157 ADCKPRSGAEEEEEENVIGNWFWEGDDTSFDPNPKPVSR 195



 Score = 38.5 bits (88), Expect = 0.046
 Identities = 36/120 (30%), Positives = 46/120 (38%), Gaps = 37/120 (30%)

Query: 590 TYMDCRAETSCDTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAK 649
           T   C+ E   D    A EE  I  SWFW   EA      NS S+  DK E  I      
Sbjct: 97  TSSTCKNEAGTDAWFWAGEEATI-NSWFWNGEEA-----GNSFSTKNDKPE--IGAQVCA 148

Query: 650 EEVSMKHGTGVRCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFW 709
           EE  ++   G  C+  +GAEE                           EEEE+++ +WFW
Sbjct: 149 EE--LEPAAGADCKPRSGAEE---------------------------EEEENVIGNWFW 179



 Score = 37.4 bits (85), Expect = 0.10
 Identities = 56/220 (25%), Positives = 81/220 (36%), Gaps = 35/220 (15%)

Query: 1   MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 60
           M G + ++ AQ K EKK   +   GA  E +   VVRP  +T+A+    A+ K  SK   
Sbjct: 1   MAGTKNKTRAQAKTEKKAAIQAKAGA--EREATGVVRPVAKTRAK----AKAKTGSKTDA 54

Query: 61  GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 120
            A  K  +     A  K  A + P +  K        P+ G E  S T +N         
Sbjct: 55  VAEMKAVSKNKVVAETKEGALSEPKTLGKAMGDF--TPKAGNESTSSTCKNE-------- 104

Query: 121 LVSTDSVLVAK-----TKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSW 175
              TD+   A        +     E  N    SF  +    + G Q      E    G+ 
Sbjct: 105 -AGTDAWFWAGEEATINSWFWNGEEAGN----SFSTKNDKPEIGAQVCAEELEPA-AGAD 158

Query: 176 CCPRPTSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHP 215
           C PR  +++E   N    W        FW GD+ +   +P
Sbjct: 159 CKPRSGAEEEEEENVIGNW--------FWEGDDTSFDPNP 190


>gi|39930463 basic helix-loop-helix domain containing, class B, 9
            [Homo sapiens]
          Length = 547

 Score =  236 bits (601), Expect = 1e-61
 Identities = 176/599 (29%), Positives = 299/599 (49%), Gaps = 67/599 (11%)

Query: 795  AETREEDRLAA--EKEGIVGSWFGAREET---IRREAGSCSKSSPKAEEEEVIIGSWFWE 849
            A T+ + R  A  EK+  + +  GA  E    +R  A + +K+  K   +   +      
Sbjct: 2    AGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVA----- 56

Query: 850  EEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESETEEETIFGS 909
             E    +   V  E+K G   E  T+G       + + +AG+   E   S  + E    +
Sbjct: 57   -EMKAVSKNKVVAETKEGALSEPKTLGKAMG---DFTPKAGN---ESTSSTCKNEAGTDA 109

Query: 910  WFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESKPENEEGAIV 969
            WFW G                  EE  + SWFW+ ++A     + +T   KPE      +
Sbjct: 110  WFWAG------------------EEATINSWFWNGEEA---GNSFSTKNDKPE------I 142

Query: 970  GSWFEAEDEVDNRTDNGSNCGSRTLADEDEA--IVGSWFWAGDEAHFESNPSPVFRAICR 1027
            G+   AE+        G++C  R+ A+E+E   ++G+WFW GD+  F+ NP PV R +  
Sbjct: 143  GAQVCAEEL---EPAAGADCKPRSGAEEEEEENVIGNWFWEGDDTSFDPNPKPVSRIVKP 199

Query: 1028 STCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRF--PKEAASLFCEMFGGK 1085
                   E +   RP+ W EVT+     P      P++  FR   P EA+     +    
Sbjct: 200  QPV---YEINEKNRPKDWSEVTIW----PNAPAVTPAVLGFRSQAPSEASPPSYIVLASA 252

Query: 1086 PRNMVLSPEG---EDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESSSC 1142
              N    P         +     QP PE  F  DP  +++ EIR  +R +E    +  +C
Sbjct: 253  EENACSLPVATACRPSRNTRSCSQPIPECRFDSDPCIQTIDEIRRQIRIREVNGIKPFAC 312

Query: 1143 NCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIE 1202
             C + E  + SEEFE+L+ L++   DP IH+I++IAMG+ +   F ++FI + GVV+LIE
Sbjct: 313  PC-KMECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQEFINEVGVVTLIE 371

Query: 1203 TLLNYPSSRVRTSFLENMIRMAPPYPN--LNIIQTYICKVCEETLAYSVDSPEQLSGIRM 1260
            +LL++PS  +R    + +I + PP  +     I+ ++  +C+ET+++ ++SP Q SG+++
Sbjct: 372  SLLSFPSPEMRK---KTVITLNPPSGDERQRKIELHVKHMCKETMSFPLNSPGQQSGLKI 428

Query: 1261 IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS 1320
            +  LTT   +H +VANY S    LL++GN KTR  VLK+LLN+SEN    +++++ +A++
Sbjct: 429  LGQLTTDFVHHYIVANYFSELFHLLSSGNCKTRNLVLKLLLNMSENPTAARDMINMKALA 488

Query: 1321 EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKEL 1379
                +FN++E   N+   +AIF NI  +I+K ++   D  +   L++ F +V++  + +
Sbjct: 489  ALKLIFNQKEAKANLVSGVAIFINIKEHIRKGSIVVVDHLSYNTLMAIFREVKEIIETM 547



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 55/196 (28%), Positives = 86/196 (43%), Gaps = 17/196 (8%)

Query: 372 KKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADEASIESSLQVED 431
           K + RA+A T+++A  +A+A A++EA      +  T   A  ++    +A  E    V  
Sbjct: 5   KNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVAEMKA-VSK 63

Query: 432 ESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGA-REKTSMKTGAEATSESILA 490
             ++             T   + S P+T G+ +GD    A  E TS     EA +++   
Sbjct: 64  NKVVAE-----------TKEGALSEPKTLGKAMGDFTPKAGNESTSSTCKNEAGTDAWFW 112

Query: 491 ADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCESRTRSEEEE-- 548
           A +E  I  SWFW GEE       +         + A  +E   G  C+ R+ +EEEE  
Sbjct: 113 AGEEATI-NSWFWNGEEAGNSFSTKNDKPEIGAQVCAEELEPAAGADCKPRSGAEEEEEE 171

Query: 549 -VIGPWFWSGEQVDIE 563
            VIG WFW G+    +
Sbjct: 172 NVIGNWFWEGDDTSFD 187



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 57/204 (27%), Positives = 93/204 (45%), Gaps = 37/204 (18%)

Query: 323 AGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPEENANTFSRPMIKKEARARAMT- 381
           AG +   RA+ + +++A I    G+            E  A    RP+ K  A+A+A T 
Sbjct: 2   AGTKNKTRAQAKTEKKAAIQAKAGA------------EREATGVVRPVAKTRAKAKAKTG 49

Query: 382 ---------KEEAKTKARARAKQEARSEEEAL---IGTWF-WATDESSMA---DEASIES 425
                    K  +K K  A  K+ A SE + L   +G +   A +ES+ +   +EA  ++
Sbjct: 50  SKTDAVAEMKAVSKNKVVAETKEGALSEPKTLGKAMGDFTPKAGNESTSSTCKNEAGTDA 109

Query: 426 SLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTGAEATS 485
                +E+ I SWFW  EEA  G   S+K+    D   IG  +    E+     GA+   
Sbjct: 110 WFWAGEEATINSWFWNGEEA--GNSFSTKN----DKPEIGAQV--CAEELEPAAGADCKP 161

Query: 486 ESILAADDEQVIIGSWFWAGEEVN 509
            S    ++E+ +IG+WFW G++ +
Sbjct: 162 RSGAEEEEEENVIGNWFWEGDDTS 185



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 59/232 (25%), Positives = 93/232 (40%), Gaps = 40/232 (17%)

Query: 228 MANQEANTMSRSQTNQELYIASSSGSEDES--VKTPWFWARDKTNTWSGPREDPNSRSRF 285
           MA  +  T ++++T ++  I + +G+E E+  V  P    R K    +G + D  +  + 
Sbjct: 1   MAGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVAEMKA 60

Query: 286 RSKKEVYVESSSGSEHEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMP 345
            SK +V  E+  G+  E         GK A      +AG E+ +      K EA  D   
Sbjct: 61  VSKNKVVAETKEGALSEPKT-----LGK-AMGDFTPKAGNESTSST---CKNEAGTDAWF 111

Query: 346 GSIDVIKKESCFWP-EENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEAL 404
            + +     S FW  EE  N+FS    K E  A+    EE +  A A  K  + +EEE  
Sbjct: 112 WAGEEATINSWFWNGEEAGNSFSTKNDKPEIGAQVCA-EELEPAAGADCKPRSGAEEE-- 168

Query: 405 IGTWFWATDESSMADEASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSR 456
                                    E+E++IG+WFW  ++ S        SR
Sbjct: 169 -------------------------EEENVIGNWFWEGDDTSFDPNPKPVSR 195



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 31/108 (28%), Positives = 48/108 (44%), Gaps = 10/108 (9%)

Query: 687 PAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAIIGSWLWATEESNIDGTGEKAKLLTEEE 746
           P  G    S   + E   ++WFW+ +    EA I SW W  EE+     G       ++ 
Sbjct: 90  PKAGNESTSSTCKNEAGTDAWFWAGE----EATINSWFWNGEEA-----GNSFSTKNDKP 140

Query: 747 TIINSWFWKEDEAISEATDREESRPEAEEGD-IIGSWFWAGEEDRLEP 793
            I      +E E  + A  +  S  E EE + +IG+WFW G++   +P
Sbjct: 141 EIGAQVCAEELEPAAGADCKPRSGAEEEEEENVIGNWFWEGDDTSFDP 188



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 57/251 (22%), Positives = 96/251 (38%), Gaps = 57/251 (22%)

Query: 50  ARPKNKSKVMPGASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTE 109
           A  KNK++       K    A  GA  ++     PV++ + +A              K +
Sbjct: 2   AGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKA--------------KAK 47

Query: 110 RNSQTNIIASPLVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEE 169
             S+T+ +A      +   V+K K ++E +E       S P+        F P   ++  
Sbjct: 48  TGSKTDAVA------EMKAVSKNKVVAETKE----GALSEPKTLGKAMGDFTPKAGNEST 97

Query: 170 TNMGSWCCPRPTSKQEASPNSDFKWV--DKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMH 227
           ++         T K EA  ++ F W   + +++S FW+G+E    F   N   +    + 
Sbjct: 98  SS---------TCKNEAGTDAWF-WAGEEATINSWFWNGEEAGNSFSTKNDKPEIGAQVC 147

Query: 228 MANQE----ANTMSRSQTNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSR- 282
               E    A+   RS   +E         E+E+V   WFW  D T+       DPN + 
Sbjct: 148 AEELEPAAGADCKPRSGAEEE---------EEENVIGNWFWEGDDTSF------DPNPKP 192

Query: 283 -SRFRSKKEVY 292
            SR    + VY
Sbjct: 193 VSRIVKPQPVY 203



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 16/99 (16%)

Query: 684 CMYPAGGGSWKSRPEEEEDIVNSWFW---------SRKYTKPEAIIGSWLWATEESNIDG 734
           C   AG  +W    EE    +NSWFW         S K  KPE  IG+ + A E     G
Sbjct: 101 CKNEAGTDAWFWAGEEAT--INSWFWNGEEAGNSFSTKNDKPE--IGAQVCAEELEPAAG 156

Query: 735 TGEKAKLLTEEE---TIINSWFWKEDEAISEATDREESR 770
              K +   EEE    +I +WFW+ D+   +   +  SR
Sbjct: 157 ADCKPRSGAEEEEEENVIGNWFWEGDDTSFDPNPKPVSR 195



 Score = 38.5 bits (88), Expect = 0.046
 Identities = 36/120 (30%), Positives = 46/120 (38%), Gaps = 37/120 (30%)

Query: 590 TYMDCRAETSCDTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAK 649
           T   C+ E   D    A EE  I  SWFW   EA      NS S+  DK E  I      
Sbjct: 97  TSSTCKNEAGTDAWFWAGEEATI-NSWFWNGEEA-----GNSFSTKNDKPE--IGAQVCA 148

Query: 650 EEVSMKHGTGVRCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFW 709
           EE  ++   G  C+  +GAEE                           EEEE+++ +WFW
Sbjct: 149 EE--LEPAAGADCKPRSGAEE---------------------------EEEENVIGNWFW 179



 Score = 37.4 bits (85), Expect = 0.10
 Identities = 56/220 (25%), Positives = 81/220 (36%), Gaps = 35/220 (15%)

Query: 1   MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP 60
           M G + ++ AQ K EKK   +   GA  E +   VVRP  +T+A+    A+ K  SK   
Sbjct: 1   MAGTKNKTRAQAKTEKKAAIQAKAGA--EREATGVVRPVAKTRAK----AKAKTGSKTDA 54

Query: 61  GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP 120
            A  K  +     A  K  A + P +  K        P+ G E  S T +N         
Sbjct: 55  VAEMKAVSKNKVVAETKEGALSEPKTLGKAMGDF--TPKAGNESTSSTCKNE-------- 104

Query: 121 LVSTDSVLVAK-----TKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSW 175
              TD+   A        +     E  N    SF  +    + G Q      E    G+ 
Sbjct: 105 -AGTDAWFWAGEEATINSWFWNGEEAGN----SFSTKNDKPEIGAQVCAEELEPA-AGAD 158

Query: 176 CCPRPTSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHP 215
           C PR  +++E   N    W        FW GD+ +   +P
Sbjct: 159 CKPRSGAEEEEEENVIGNW--------FWEGDDTSFDPNP 190


>gi|41054846 armadillo repeat containing, X-linked 5 [Homo sapiens]
          Length = 558

 Score =  197 bits (500), Expect = 8e-50
 Identities = 133/461 (28%), Positives = 242/461 (52%), Gaps = 35/461 (7%)

Query: 943  SRDKAIKETGTVATCESKPENEEGAIVGSWFEAEDEVD--NRTDNG--SNCGSRTLADED 998
            S+   +    TV   E K      A + S+ ++ D+ +  +R D    ++ G ++ +DED
Sbjct: 108  SKAMPMSRVSTVTKSEVKVVAVIEANIRSYAKSHDKANTGSRPDRREETSIGMKS-SDED 166

Query: 999  EAIVGSWFWAGDEAHFESNPSPVFRA---ICRSTCSVEQEPDPSRRPQSWEEVTVQFKPG 1055
            E  + SWFW G+E    S   P       + +    ++++P P+ +P     +T++ K  
Sbjct: 167  EENICSWFWTGEEPSVGSWFWPEEETSLQVYKPLPKIQEKPKPTHKPT----LTIKQKVI 222

Query: 1056 PWGRVGFPSISPFRFPKEAASLFCEMFGGKPRNMVLSPEGEDQ--ESLLQPD---QPSPE 1110
             W R  +  + P               GG+     L PEG     E+L++     +P  +
Sbjct: 223  AWSRARYIVLVPVE-------------GGEQS---LPPEGNWTLVETLIETPLGIRPLTK 266

Query: 1111 FPFQYDPSYRSVQEIREHLRAKESTEPESSSCNCIQCELKIGSEEFEELLLLMEKIRDPF 1170
             P  + P Y+++ EI++ +R +E   P   +C+C      +  +EF++L+ L++  +DPF
Sbjct: 267  IPPYHGPYYQTLAEIKKQIRQREKYGPNPKACHCKSRGFSLEPKEFDKLVALLKLTKDPF 326

Query: 1171 IHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIRMAPPYPNL 1230
            IHEI+ + MG+  A  FT+D I D G+  +IE L+N P+ +     L  +   +      
Sbjct: 327  IHEIATMIMGISPAYPFTQDIIHDVGITVMIENLVNNPNVKEHPGALSMVDDSSESSEEP 386

Query: 1231 NIIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDYHTLVANYMSGFLSLLATGNA 1290
               ++YI +VC+  ++  ++SP QL+G++++ HL+   + H ++ +Y+  FL+LL  G+ 
Sbjct: 387  KSGESYIHQVCKGIISCPLNSPVQLAGLKLLGHLSIKFEDHYVITSYIPDFLTLLNKGSV 446

Query: 1291 KTRFHVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREETNDNIQIVLAIFENIGNNIK 1350
            KT+F+VLK+   LS+N   T+EL+SA+ +S  +  FN+ E+  NI  ++ IFENI    K
Sbjct: 447  KTKFYVLKVFSCLSKNHANTRELISAKVLSSLVAPFNKNESKANILNIIEIFENINFQFK 506

Query: 1351 -KETVFSDDDFNIEPLISAFHKVEKFAKELQGKTDNQNDPE 1390
             K  +F+ + F    LIS F + ++F ++LQ   ++ +DPE
Sbjct: 507  TKAKLFTKEKFTKSELISIFQEAKQFGQKLQDLAEH-SDPE 546



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 41/145 (28%), Positives = 61/145 (42%), Gaps = 24/145 (16%)

Query: 319 SKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPEENANTFSRPMIKKE---- 374
           ++ +AG  A  R      REA    M  + +VIK E          T ++P+ ++     
Sbjct: 50  TQAKAGDGAMTRTHTVTYREA----MAVTREVIKVEDTTKTRVMVETKTKPLAERSIVPQ 105

Query: 375 --------ARARAMTKEEAKTKA--RARAKQEARSEEEALIGTWFWATDESSMADEASIE 424
                   +R   +TK E K  A   A  +  A+S ++A  G+           +E SI 
Sbjct: 106 TKSKAMPMSRVSTVTKSEVKVVAVIEANIRSYAKSHDKANTGS------RPDRREETSIG 159

Query: 425 SSLQVEDESIIGSWFWTEEEASMGT 449
                EDE  I SWFWT EE S+G+
Sbjct: 160 MKSSDEDEENICSWFWTGEEPSVGS 184



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 28/86 (32%), Positives = 36/86 (41%), Gaps = 24/86 (27%)

Query: 823 RREAGSCSKSSPKAEEEEVIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPE 882
           RRE  S    S   +EE +   SWFW  E                    E +VGSWFWPE
Sbjct: 152 RREETSIGMKSSDEDEENIC--SWFWTGE--------------------EPSVGSWFWPE 189

Query: 883 EEASIQAGS--QAVEEMESETEEETI 906
           EE S+Q       ++E    T + T+
Sbjct: 190 EETSLQVYKPLPKIQEKPKPTHKPTL 215



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 54/233 (23%), Positives = 90/233 (38%), Gaps = 53/233 (22%)

Query: 311 AGKEAKFRSKMRAGKE------ANNRARHRAKREACIDFMPGSIDVIKKESCFWPEENAN 364
           +G EA+ R K  AG +      A  R   + + EA  +        +K ES    +    
Sbjct: 4   SGTEARARGKAEAGLQDGISGPATARVNGKTQAEAVAEAE------LKTESVTQAKAGDG 57

Query: 365 TFSRPMIKKEARARAMTKE------EAKTKARARAKQEARSEEEALIGTWFWATDESSMA 418
             +R        A A+T+E        KT+     K +  +E   +  T   A   S ++
Sbjct: 58  AMTRTHTVTYREAMAVTREVIKVEDTTKTRVMVETKTKPLAERSIVPQTKSKAMPMSRVS 117

Query: 419 DEASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMK 478
                E  +    E+ I S+  + ++A+ G      SRP              RE+TS+ 
Sbjct: 118 TVTKSEVKVVAVIEANIRSYAKSHDKANTG------SRP------------DRREETSI- 158

Query: 479 TGAEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVE 531
                    + ++D+++  I SWFW GEE +         GSWFW  +  S++
Sbjct: 159 --------GMKSSDEDEENICSWFWTGEEPS--------VGSWFWPEEETSLQ 195



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 43/196 (21%), Positives = 82/196 (41%), Gaps = 15/196 (7%)

Query: 86  SRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASPLVSTDSVLVAKTKYLSEDRELVNTD 145
           +R + +A+   Q        ++    +Q   +A   + T+SV  AK    + D  +  T 
Sbjct: 8   ARARGKAEAGLQDGISGPATARVNGKTQAEAVAEAELKTESVTQAK----AGDGAMTRTH 63

Query: 146 TESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRPTSKQEASPNSDFKWVDKS-VSSLFW 204
           T ++    A  +   +    +K    + +    +P +++   P +  K +  S VS++  
Sbjct: 64  TVTYREAMAVTREVIKVEDTTKTRVMVETKT--KPLAERSIVPQTKSKAMPMSRVSTVTK 121

Query: 205 SGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQTNQELYIASSSGSEDESVKTPWFW 264
           S  +V A       ++ + RS   ++ +ANT SR    +E  I   S  EDE     WFW
Sbjct: 122 SEVKVVAV------IEANIRSYAKSHDKANTGSRPDRREETSIGMKSSDEDEENICSWFW 175

Query: 265 ARDK--TNTWSGPRED 278
             ++    +W  P E+
Sbjct: 176 TGEEPSVGSWFWPEEE 191



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 18/39 (46%), Positives = 24/39 (61%), Gaps = 5/39 (12%)

Query: 694 KSRPEEEEDIVNSWFWSRKYTKPEAIIGSWLWATEESNI 732
           KS  E+EE+I  SWFW    T  E  +GSW W  EE+++
Sbjct: 161 KSSDEDEENIC-SWFW----TGEEPSVGSWFWPEEETSL 194



 Score = 35.4 bits (80), Expect = 0.39
 Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 22/60 (36%)

Query: 531 ESGVGVSCESRTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQT 590
           E+ +G+    ++  E+EE I  WFW+GE+  +                  GSWFW E +T
Sbjct: 155 ETSIGM----KSSDEDEENICSWFWTGEEPSV------------------GSWFWPEEET 192



 Score = 32.0 bits (71), Expect = 4.3
 Identities = 28/93 (30%), Positives = 37/93 (39%), Gaps = 26/93 (27%)

Query: 735 TGEKAKLLTEEETIINSWFWKEDEAI--SEATDREES----RPEAEEGDIIGSWFWAGEE 788
           T  + K++   E  I S+    D+A   S    REE+    +   E+ + I SWFW GEE
Sbjct: 120 TKSEVKVVAVIEANIRSYAKSHDKANTGSRPDRREETSIGMKSSDEDEENICSWFWTGEE 179

Query: 789 DRLEPAAETREEDRLAAEKEGIVGSWFGAREET 821
                                 VGSWF   EET
Sbjct: 180 PS--------------------VGSWFWPEEET 192


>gi|29540566 armadillo repeat containing, X-linked 3 [Homo sapiens]
          Length = 379

 Score =  137 bits (345), Expect = 7e-32
 Identities = 73/202 (36%), Positives = 122/202 (60%)

Query: 1151 IGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSS 1210
            +  +E +++L L+E    P+I E + IA+G  +A  F RD IRD G + ++  +LN    
Sbjct: 118  LSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNRDIIRDLGGLPIVAKILNTRDP 177

Query: 1211 RVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDY 1270
             V+   L  +  ++    N   ++ Y+ +VC++T+   ++S  QL+G+R++ ++T T +Y
Sbjct: 178  IVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEY 237

Query: 1271 HTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREE 1330
              ++AN +S F  L + GN +T+  VLK+LLNL+EN  MT+ELL A+  S    LFN++E
Sbjct: 238  QHMLANSISDFFRLFSAGNEETKLQVLKLLLNLAENPAMTRELLRAQVPSSLGSLFNKKE 297

Query: 1331 TNDNIQIVLAIFENIGNNIKKE 1352
              + I  +L IFENI +N K E
Sbjct: 298  NKEVILKLLVIFENINDNFKWE 319


>gi|29540564 armadillo repeat containing, X-linked 3 [Homo sapiens]
          Length = 379

 Score =  137 bits (345), Expect = 7e-32
 Identities = 73/202 (36%), Positives = 122/202 (60%)

Query: 1151 IGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSS 1210
            +  +E +++L L+E    P+I E + IA+G  +A  F RD IRD G + ++  +LN    
Sbjct: 118  LSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNRDIIRDLGGLPIVAKILNTRDP 177

Query: 1211 RVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDY 1270
             V+   L  +  ++    N   ++ Y+ +VC++T+   ++S  QL+G+R++ ++T T +Y
Sbjct: 178  IVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEY 237

Query: 1271 HTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREE 1330
              ++AN +S F  L + GN +T+  VLK+LLNL+EN  MT+ELL A+  S    LFN++E
Sbjct: 238  QHMLANSISDFFRLFSAGNEETKLQVLKLLLNLAENPAMTRELLRAQVPSSLGSLFNKKE 297

Query: 1331 TNDNIQIVLAIFENIGNNIKKE 1352
              + I  +L IFENI +N K E
Sbjct: 298  NKEVILKLLVIFENINDNFKWE 319


>gi|7705274 armadillo repeat containing, X-linked 3 [Homo sapiens]
          Length = 379

 Score =  137 bits (345), Expect = 7e-32
 Identities = 73/202 (36%), Positives = 122/202 (60%)

Query: 1151 IGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSS 1210
            +  +E +++L L+E    P+I E + IA+G  +A  F RD IRD G + ++  +LN    
Sbjct: 118  LSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNRDIIRDLGGLPIVAKILNTRDP 177

Query: 1211 RVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDY 1270
             V+   L  +  ++    N   ++ Y+ +VC++T+   ++S  QL+G+R++ ++T T +Y
Sbjct: 178  IVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEY 237

Query: 1271 HTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREE 1330
              ++AN +S F  L + GN +T+  VLK+LLNL+EN  MT+ELL A+  S    LFN++E
Sbjct: 238  QHMLANSISDFFRLFSAGNEETKLQVLKLLLNLAENPAMTRELLRAQVPSSLGSLFNKKE 297

Query: 1331 TNDNIQIVLAIFENIGNNIKKE 1352
              + I  +L IFENI +N K E
Sbjct: 298  NKEVILKLLVIFENINDNFKWE 319


>gi|7706143 armadillo repeat containing, X-linked 1 [Homo sapiens]
          Length = 453

 Score =  134 bits (338), Expect = 5e-31
 Identities = 73/239 (30%), Positives = 135/239 (56%), Gaps = 2/239 (0%)

Query: 1151 IGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSS 1210
            + + + +++L ++E+  DPFI E++ + +G  +A  F ++ IR+ G V +I  L+     
Sbjct: 202  LSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQNAIRELGGVPIIAKLIKTKDP 261

Query: 1211 RVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDY 1270
             +R      +  ++    N   I+TYI +VC++T+   +DS  Q++G+R++ ++T T  Y
Sbjct: 262  IIREKTYNALNNLSVNAENQGKIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHY 321

Query: 1271 HTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREE 1330
              L++     F +LL  GN  T+  ++K+++N +EN  MT+EL+S +  SE I LFN+E 
Sbjct: 322  QHLLSYSFPDFFALLFLGNHFTKIQIMKLIINFTENPAMTRELVSCKVPSELISLFNKEW 381

Query: 1331 TNDNIQIVLAIFENIGNNIKKETVFSD-DDFNIEPLISAFHKVEKFAKELQGKTDNQND 1388
              + +  +L +FENI +NIK E + S   +F+   L   F +     K+++    N ND
Sbjct: 382  DREILLNILTLFENINDNIKNEGLASSRKEFSRSSLFFLFKESGVCVKKIKALA-NHND 439


>gi|238776793 SVH protein isoform b [Homo sapiens]
          Length = 308

 Score =  120 bits (302), Expect = 7e-27
 Identities = 63/202 (31%), Positives = 116/202 (57%)

Query: 1151 IGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSS 1210
            + +E+ ++LL L+E   DP I E + I +G  +A    +  IR+ G + ++   +N+ + 
Sbjct: 58   LNAEQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQ 117

Query: 1211 RVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDY 1270
             ++   L  +  ++    N   I+ YI +VCE+  +  ++S  QL+G+ ++ ++T T D+
Sbjct: 118  SIKEKALNALNNLSVNVENQIKIKIYISQVCEDVFSGPLNSAVQLAGLTLLTNMTVTNDH 177

Query: 1271 HTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREE 1330
              ++ +Y++    +L TGN  T+  VLK+LLNLSEN  MT+ LL A+  S F+ L++   
Sbjct: 178  QHMLHSYITDLFQVLLTGNGNTKVQVLKLLLNLSENPAMTEGLLRAQVDSSFLSLYDSHV 237

Query: 1331 TNDNIQIVLAIFENIGNNIKKE 1352
              + +  VL +F+NI N +K E
Sbjct: 238  AKEILLRVLTLFQNIKNCLKIE 259


>gi|31377663 SVH protein isoform a [Homo sapiens]
          Length = 343

 Score =  120 bits (302), Expect = 7e-27
 Identities = 63/202 (31%), Positives = 116/202 (57%)

Query: 1151 IGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSS 1210
            + +E+ ++LL L+E   DP I E + I +G  +A    +  IR+ G + ++   +N+ + 
Sbjct: 93   LNAEQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQ 152

Query: 1211 RVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDY 1270
             ++   L  +  ++    N   I+ YI +VCE+  +  ++S  QL+G+ ++ ++T T D+
Sbjct: 153  SIKEKALNALNNLSVNVENQIKIKIYISQVCEDVFSGPLNSAVQLAGLTLLTNMTVTNDH 212

Query: 1271 HTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREE 1330
              ++ +Y++    +L TGN  T+  VLK+LLNLSEN  MT+ LL A+  S F+ L++   
Sbjct: 213  QHMLHSYITDLFQVLLTGNGNTKVQVLKLLLNLSENPAMTEGLLRAQVDSSFLSLYDSHV 272

Query: 1331 TNDNIQIVLAIFENIGNNIKKE 1352
              + +  VL +F+NI N +K E
Sbjct: 273  AKEILLRVLTLFQNIKNCLKIE 294


>gi|7662162 ALEX2 protein [Homo sapiens]
          Length = 632

 Score =  111 bits (277), Expect = 6e-24
 Identities = 60/211 (28%), Positives = 117/211 (55%), Gaps = 1/211 (0%)

Query: 1151 IGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSS 1210
            +G  +  ++L L++K  DPFI +++ + +   +     ++ IR  G + +I  ++N    
Sbjct: 383  LGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQETIRKLGGLPIIANMINKTDP 442

Query: 1211 RVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDY 1270
             ++   L  M  ++  Y N   +Q Y+ KV ++ +A +++S  Q+ G++ + ++T T DY
Sbjct: 443  HIKEKALMAMNNLSENYENQGRLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDY 502

Query: 1271 HTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREE 1330
              L+ N ++ F  LL+ G  K +  +LK+L N +EN  M K+LLS +  + F  L+N   
Sbjct: 503  QHLLVNSIANFFRLLSQGGGKIKVEILKILSNFAENPDMLKKLLSTQVPASFSSLYNSYV 562

Query: 1331 TNDNIQIVLAIFENIGNNIKKETVFSDDDFN 1361
             ++ +   L +FE I +N++ E VF+  +FN
Sbjct: 563  ESEILINALTLFEIIYDNLRAE-VFNYREFN 592


>gi|29540562 ALEX2 protein [Homo sapiens]
          Length = 632

 Score =  111 bits (277), Expect = 6e-24
 Identities = 60/211 (28%), Positives = 117/211 (55%), Gaps = 1/211 (0%)

Query: 1151 IGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSS 1210
            +G  +  ++L L++K  DPFI +++ + +   +     ++ IR  G + +I  ++N    
Sbjct: 383  LGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQETIRKLGGLPIIANMINKTDP 442

Query: 1211 RVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDY 1270
             ++   L  M  ++  Y N   +Q Y+ KV ++ +A +++S  Q+ G++ + ++T T DY
Sbjct: 443  HIKEKALMAMNNLSENYENQGRLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDY 502

Query: 1271 HTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREE 1330
              L+ N ++ F  LL+ G  K +  +LK+L N +EN  M K+LLS +  + F  L+N   
Sbjct: 503  QHLLVNSIANFFRLLSQGGGKIKVEILKILSNFAENPDMLKKLLSTQVPASFSSLYNSYV 562

Query: 1331 TNDNIQIVLAIFENIGNNIKKETVFSDDDFN 1361
             ++ +   L +FE I +N++ E VF+  +FN
Sbjct: 563  ESEILINALTLFEIIYDNLRAE-VFNYREFN 592


>gi|169165522 PREDICTED: similar to SVH protein isoform 1 [Homo
            sapiens]
          Length = 284

 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 49/202 (24%), Positives = 99/202 (49%), Gaps = 24/202 (11%)

Query: 1151 IGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSS 1210
            + +E+ ++LL L+E   DP I E + I +G  +A    +  IR+ G + ++   +N+ + 
Sbjct: 58   LNAEQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQ 117

Query: 1211 RVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDY 1270
             ++   L  +  ++    N   I+ YI +VCE+  +  ++S  QL+G+R++ ++T T D+
Sbjct: 118  SIKEKALNALNNLSVNVENQIKIKIYISQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDH 177

Query: 1271 HTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREE 1330
              ++ +Y++    +L TGN  T+                          S F+ L++   
Sbjct: 178  QHMLHSYITDLFQVLLTGNGNTKVD------------------------SSFLSLYDSHV 213

Query: 1331 TNDNIQIVLAIFENIGNNIKKE 1352
              + +  VL +F+NI N +K E
Sbjct: 214  AKEILLRVLTLFQNIKNCLKIE 235


>gi|169165931 PREDICTED: similar to SVH protein isoform 1 [Homo
            sapiens]
          Length = 284

 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 48/202 (23%), Positives = 99/202 (49%), Gaps = 24/202 (11%)

Query: 1151 IGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSS 1210
            + +E+ ++LL L+E   DP I E + I +G  +A    +  IR+ G + ++   +N+ + 
Sbjct: 58   LNAEQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQ 117

Query: 1211 RVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDY 1270
             ++   L  +  ++    N   I+ YI +VCE+  +  ++S  QL+G+R++ ++T T D+
Sbjct: 118  SIKDKALNALNNLSVNVENQIKIKIYISQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDH 177

Query: 1271 HTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREE 1330
              ++ +Y++    +L TGN  T+                          S F+ L++   
Sbjct: 178  QHMLHSYITDLFQVLLTGNGNTKVD------------------------SSFLSLYDSHV 213

Query: 1331 TNDNIQIVLAIFENIGNNIKKE 1352
              + +  VL +F++I N +K E
Sbjct: 214  AKEILLRVLTLFQHIKNCLKIE 235


>gi|113414573 PREDICTED: similar to SVH protein isoform 2 [Homo
            sapiens]
          Length = 284

 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 48/202 (23%), Positives = 99/202 (49%), Gaps = 24/202 (11%)

Query: 1151 IGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSS 1210
            + +E+ ++LL L+E   DP I E + I +G  +A    +  IR+ G + ++   +N+ + 
Sbjct: 58   LNAEQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQ 117

Query: 1211 RVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDY 1270
             ++   L  +  ++    N   I+ YI +VCE+  +  ++S  QL+G+R++ ++T T D+
Sbjct: 118  SIKDKALNALNNLSVNVENQIKIKIYISQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDH 177

Query: 1271 HTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREE 1330
              ++ +Y++    +L TGN  T+                          S F+ L++   
Sbjct: 178  QHMLHSYITDLFQVLLTGNGNTKVD------------------------SSFLSLYDSHV 213

Query: 1331 TNDNIQIVLAIFENIGNNIKKE 1352
              + +  VL +F++I N +K E
Sbjct: 214  AKEILLRVLTLFQHIKNCLKIE 235


>gi|238776797 SVH protein isoform e [Homo sapiens]
          Length = 284

 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 48/202 (23%), Positives = 98/202 (48%), Gaps = 24/202 (11%)

Query: 1151 IGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSS 1210
            + +E+ ++LL L+E   DP I E + I +G  +A    +  IR+ G + ++   +N+ + 
Sbjct: 58   LNAEQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQ 117

Query: 1211 RVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDY 1270
             ++   L  +  ++    N   I+ YI +VCE+  +  ++S  QL+G+ ++ ++T T D+
Sbjct: 118  SIKEKALNALNNLSVNVENQIKIKIYISQVCEDVFSGPLNSAVQLAGLTLLTNMTVTNDH 177

Query: 1271 HTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREE 1330
              ++ +Y++    +L TGN  T+                          S F+ L++   
Sbjct: 178  QHMLHSYITDLFQVLLTGNGNTKVD------------------------SSFLSLYDSHV 213

Query: 1331 TNDNIQIVLAIFENIGNNIKKE 1352
              + +  VL +F+NI N +K E
Sbjct: 214  AKEILLRVLTLFQNIKNCLKIE 235


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 83/298 (27%), Positives = 110/298 (36%), Gaps = 33/298 (11%)

Query: 728  EESNIDGTGEKAKLLTEEE--TIINSWFWKEDEAISEATDREESRPEAEEGDIIGSWFWA 785
            EE   +G GE+ +   E E   +      +E+E      + EE   E EEG+        
Sbjct: 797  EEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGE-------- 848

Query: 786  GEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEEVIIGS 845
            GEE+  E   E   E+    E+EG  G   G  EE    E     +   + EEEE   G 
Sbjct: 849  GEEEEGEGKGEEEGEEG-EGEEEGEEGEGEGEEEEG---EGEGEEEGEGEGEEEE---GE 901

Query: 846  WFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQA----GSQAVEEMESET 901
               EEE   E       E   G  EEE   G     EEE   +     G    EE E E 
Sbjct: 902  GEGEEEGEGEGEE----EEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEG 957

Query: 902  EEETIFGSWFWDGK--------EVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGT 953
            EEE   G    +G+        E  EE G     + E +EE   E       +   E   
Sbjct: 958  EEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEE 1017

Query: 954  VATCESKPENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDE 1011
                E + E EEG   G   E E+E + R   G    +R   +E+E   G +   G+E
Sbjct: 1018 EGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEE 1075



 Score = 39.7 bits (91), Expect = 0.020
 Identities = 80/323 (24%), Positives = 113/323 (34%), Gaps = 29/323 (8%)

Query: 382  KEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADEASIESSLQVEDESIIGSWFWT 441
            KEE + K   RA +E + EEE   G      +E +       E   +VE   +       
Sbjct: 770  KEEGERKKEERAGKEEKGEEEGDQGE---GEEEETEGRGEEKEEGGEVEGGEVEEGKGER 826

Query: 442  EEEASMGTGASSKSR-PRTDGERIGDSLFGAREKTSMKTGAEATSESILAADDEQVIIGS 500
            EEE   G G   +      +GE   +   G  E+   +   E   E      +E+   G 
Sbjct: 827  EEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGE 886

Query: 501  WFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCESRTRSEEEEVIGPWFWSGEQV 560
                GE   +E E E          +      G G   E   + EEE   G     GE+ 
Sbjct: 887  GEEEGEGEGEEEEGEG---------EGEEEGEGEGEEEEGEGKGEEEGEEGE--GEGEEE 935

Query: 561  DIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSCDTMQGAEEEEPIIGSWFWTR 620
            + E G GE+     EEE   G W   E +   +   E   +  +G  E E   G      
Sbjct: 936  EGE-GEGEDGEGEGEEEE--GEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEE 992

Query: 621  VEACVEGDVNSKSSLEDKEEAMIPCFGAKE-EVSMKHGTGVRCRFMAGAEETNNKSCFWA 679
             E   EG+   +   E + E      G  E EV  + G G       G EE   +     
Sbjct: 993  EEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEG------EGEEEEGEEEGEER 1046

Query: 680  EKEPCMYPAGGGSWKSRPEEEED 702
            EKE      G  + ++R EEEE+
Sbjct: 1047 EKE----GEGEENRRNREEEEEE 1065



 Score = 38.5 bits (88), Expect = 0.046
 Identities = 68/269 (25%), Positives = 95/269 (35%), Gaps = 25/269 (9%)

Query: 743 TEEETIINSWFWKEDEAISEATDR---EESRPEAEEGDIIGSWFWA---GEEDRLEPAAE 796
           T EE    +  W+++E      D+   E  RP   E ++     W    GEE   +   +
Sbjct: 658 TCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQ 717

Query: 797 TREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEEVIIGSWFWEEEASPEA 856
             +++R    +EG         EE   RE     +   K E E   +     +EE   + 
Sbjct: 718 GHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKK 777

Query: 857 VAGVGFESK------PGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESETEEETIFGSW 910
               G E K       G  EEE T G     EE   ++ G   VEE + E EEE   G  
Sbjct: 778 EERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGE--VEEGKGEREEEEEEGEG 835

Query: 911 FWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESKPENEEGAIVG 970
             +  E  EE G     + E+ E    E       +   E G     E + E EEG   G
Sbjct: 836 EEEEGEGEEEEGE---GEEEEGEGKGEEEGEEGEGEEEGEEG-----EGEGEEEEGEGEG 887

Query: 971 SWFEAEDEVDNRTDNGSNCGSRTLADEDE 999
              E E E +   + G   G      E E
Sbjct: 888 ---EEEGEGEGEEEEGEGEGEEEGEGEGE 913


>gi|169165524 PREDICTED: similar to SVH protein isoform 2 [Homo
            sapiens]
          Length = 253

 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 40/157 (25%), Positives = 75/157 (47%), Gaps = 17/157 (10%)

Query: 1151 IGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSS 1210
            + +E+ ++LL L+E   DP I E + I +G  +A    +  IR+ G + ++   +N+ + 
Sbjct: 58   LNAEQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQ 117

Query: 1211 RVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDY 1270
             ++   L  +  ++    N   I+ YI +VCE+  +  ++S   L+G     +  T  D 
Sbjct: 118  SIKEKALNALNNLSVNVENQIKIKIYISQVCEDVFSGPLNSAVLLTG-----NGNTKVD- 171

Query: 1271 HTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENL 1307
                    S FLSL  +  AK    +L  +L L +N+
Sbjct: 172  --------SSFLSLYDSHVAK---EILLRVLTLFQNI 197


>gi|238776799 SVH protein isoform d [Homo sapiens]
          Length = 249

 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 29/71 (40%), Positives = 42/71 (59%)

Query: 1282 LSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREETNDNIQIVLAI 1341
            LS+      K +  VLK+LLNLSEN  MT+ LL A+  S F+ L++     + +  VL +
Sbjct: 130  LSVNVENQIKIKVQVLKLLLNLSENPAMTEGLLRAQVDSSFLSLYDSHVAKEILLRVLTL 189

Query: 1342 FENIGNNIKKE 1352
            F+NI N +K E
Sbjct: 190  FQNIKNCLKIE 200



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 36/157 (22%), Positives = 69/157 (43%), Gaps = 21/157 (13%)

Query: 1151 IGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSS 1210
            + +E+ ++LL L+E   DP I E + I +G  +A    +  IR+ G + ++   +N+ + 
Sbjct: 58   LNAEQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQAIIRELGGIPIVANKINHSNQ 117

Query: 1211 RVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDY 1270
             ++   L  +  ++    N   I+  + K+    L    ++P    G+            
Sbjct: 118  SIKEKALNALNNLSVNVENQIKIKVQVLKL----LLNLSENPAMTEGL------------ 161

Query: 1271 HTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENL 1307
              L A   S FLSL  +  AK    +L  +L L +N+
Sbjct: 162  --LRAQVDSSFLSLYDSHVAK---EILLRVLTLFQNI 193


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.127    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,018,906
Number of Sequences: 37866
Number of extensions: 2849621
Number of successful extensions: 9548
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 141
Number of HSP's that attempted gapping in prelim test: 7033
Number of HSP's gapped (non-prelim): 773
length of query: 1395
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1280
effective length of database: 13,892,928
effective search space: 17782947840
effective search space used: 17782947840
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.