Guide to the Human Genome
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Search of human proteins with 150378463

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|150378463 MYST histone acetyltransferase (monocytic
leukemia) 3 [Homo sapiens]
         (2004 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|150378543 MYST histone acetyltransferase (monocytic leukemia)...  4073   0.0  
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)...  4073   0.0  
gi|150378493 MYST histone acetyltransferase (monocytic leukemia)...  4073   0.0  
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)...  1310   0.0  
gi|5901962 MYST histone acetyltransferase 2 [Homo sapiens]            365   e-100
gi|226371636 MYST histone acetyltransferase 1 isoform 1 [Homo sa...   315   2e-85
gi|36287069 K(lysine) acetyltransferase 5 isoform 1 [Homo sapiens]    303   9e-82
gi|36287060 K(lysine) acetyltransferase 5 isoform 3 [Homo sapiens]    303   9e-82
gi|36287049 K(lysine) acetyltransferase 5 isoform 2 [Homo sapiens]    303   9e-82
gi|226371638 MYST histone acetyltransferase 1 isoform 2 [Homo sa...   300   7e-81
gi|205830434 D4, zinc and double PHD fingers family 1 isoform c ...   137   1e-31
gi|205830430 D4, zinc and double PHD fingers family 1 isoform a ...   137   1e-31
gi|5454004 D4, zinc and double PHD fingers family 2 [Homo sapiens]    136   2e-31
gi|205830432 D4, zinc and double PHD fingers family 1 isoform b ...   130   1e-29
gi|194328736 PHD finger protein 10 isoform b [Homo sapiens]           122   3e-27
gi|194328734 PHD finger protein 10 isoform a [Homo sapiens]           122   3e-27
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    91   9e-18
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     90   2e-17
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ...    89   6e-17
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    87   2e-16
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    87   2e-16
gi|148746195 trichohyalin [Homo sapiens]                               86   5e-16
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    86   5e-16
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]    85   6e-16
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]    85   6e-16
gi|114431236 zinc finger protein 462 [Homo sapiens]                    85   8e-16
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]             84   2e-15
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    83   2e-15
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              83   3e-15
gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi...    80   2e-14

>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
            [Homo sapiens]
          Length = 2004

 Score = 4073 bits (10562), Expect = 0.0
 Identities = 2004/2004 (100%), Positives = 2004/2004 (100%)

Query: 1    MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTI 60
            MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTI
Sbjct: 1    MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTI 60

Query: 61   LKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQNVDWNKLIKRAVEGLAESGGSTLKS 120
            LKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQNVDWNKLIKRAVEGLAESGGSTLKS
Sbjct: 61   LKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQNVDWNKLIKRAVEGLAESGGSTLKS 120

Query: 121  IERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE 180
            IERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
Sbjct: 121  IERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE 180

Query: 181  SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPS 240
            SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPS
Sbjct: 181  SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPS 240

Query: 241  CLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRM 300
            CLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRM
Sbjct: 241  CLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRM 300

Query: 301  PKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP 360
            PKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
Sbjct: 301  PKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP 360

Query: 361  GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPS 420
            GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPS
Sbjct: 361  GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPS 420

Query: 421  PDGRKARGEVVDYSEQYRIRKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGSQEIMTEK 480
            PDGRKARGEVVDYSEQYRIRKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGSQEIMTEK
Sbjct: 421  PDGRKARGEVVDYSEQYRIRKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGSQEIMTEK 480

Query: 481  DMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC 540
            DMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
Sbjct: 481  DMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC 540

Query: 541  EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLF 600
            EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLF
Sbjct: 541  EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLF 600

Query: 601  LDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGR 660
            LDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGR
Sbjct: 601  LDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGR 660

Query: 661  FLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT 720
            FLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
Sbjct: 661  FLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT 720

Query: 721  GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVI 780
            GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVI
Sbjct: 721  GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVI 780

Query: 781  VSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAP 840
            VSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAP
Sbjct: 781  VSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAP 840

Query: 841  VSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG 900
            VSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG
Sbjct: 841  VSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG 900

Query: 901  ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKC 960
            ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKC
Sbjct: 901  ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKC 960

Query: 961  RLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRR 1020
            RLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRR
Sbjct: 961  RLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRR 1020

Query: 1021 RRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF 1080
            RRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF
Sbjct: 1021 RRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF 1080

Query: 1081 PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEP 1140
            PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEP
Sbjct: 1081 PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEP 1140

Query: 1141 DTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGR 1200
            DTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGR
Sbjct: 1141 DTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGR 1200

Query: 1201 KPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNS 1260
            KPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNS
Sbjct: 1201 KPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNS 1260

Query: 1261 PETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDED 1320
            PETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDED
Sbjct: 1261 PETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDED 1320

Query: 1321 DGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSH 1380
            DGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSH
Sbjct: 1321 DGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSH 1380

Query: 1381 DTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHE 1440
            DTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHE
Sbjct: 1381 DTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHE 1440

Query: 1441 GAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSP 1500
            GAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSP
Sbjct: 1441 GAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSP 1500

Query: 1501 NVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTT 1560
            NVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTT
Sbjct: 1501 NVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTT 1560

Query: 1561 ENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQ 1620
            ENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQ
Sbjct: 1561 ENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQ 1620

Query: 1621 QSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQ 1680
            QSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQ
Sbjct: 1621 QSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQ 1680

Query: 1681 QQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFG 1740
            QQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFG
Sbjct: 1681 QQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFG 1740

Query: 1741 AGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPL 1800
            AGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPL
Sbjct: 1741 AGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPL 1800

Query: 1801 AGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSK 1860
            AGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSK
Sbjct: 1801 AGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSK 1860

Query: 1861 SAPLPSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLN 1920
            SAPLPSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLN
Sbjct: 1861 SAPLPSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLN 1920

Query: 1921 AMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYTG 1980
            AMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYTG
Sbjct: 1921 AMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYTG 1980

Query: 1981 PSHHSYMNAAGVPKQSLNGPYMRR 2004
            PSHHSYMNAAGVPKQSLNGPYMRR
Sbjct: 1981 PSHHSYMNAAGVPKQSLNGPYMRR 2004


>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
            [Homo sapiens]
          Length = 2004

 Score = 4073 bits (10562), Expect = 0.0
 Identities = 2004/2004 (100%), Positives = 2004/2004 (100%)

Query: 1    MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTI 60
            MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTI
Sbjct: 1    MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTI 60

Query: 61   LKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQNVDWNKLIKRAVEGLAESGGSTLKS 120
            LKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQNVDWNKLIKRAVEGLAESGGSTLKS
Sbjct: 61   LKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQNVDWNKLIKRAVEGLAESGGSTLKS 120

Query: 121  IERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE 180
            IERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
Sbjct: 121  IERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE 180

Query: 181  SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPS 240
            SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPS
Sbjct: 181  SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPS 240

Query: 241  CLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRM 300
            CLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRM
Sbjct: 241  CLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRM 300

Query: 301  PKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP 360
            PKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
Sbjct: 301  PKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP 360

Query: 361  GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPS 420
            GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPS
Sbjct: 361  GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPS 420

Query: 421  PDGRKARGEVVDYSEQYRIRKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGSQEIMTEK 480
            PDGRKARGEVVDYSEQYRIRKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGSQEIMTEK
Sbjct: 421  PDGRKARGEVVDYSEQYRIRKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGSQEIMTEK 480

Query: 481  DMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC 540
            DMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
Sbjct: 481  DMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC 540

Query: 541  EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLF 600
            EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLF
Sbjct: 541  EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLF 600

Query: 601  LDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGR 660
            LDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGR
Sbjct: 601  LDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGR 660

Query: 661  FLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT 720
            FLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
Sbjct: 661  FLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT 720

Query: 721  GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVI 780
            GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVI
Sbjct: 721  GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVI 780

Query: 781  VSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAP 840
            VSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAP
Sbjct: 781  VSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAP 840

Query: 841  VSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG 900
            VSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG
Sbjct: 841  VSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG 900

Query: 901  ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKC 960
            ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKC
Sbjct: 901  ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKC 960

Query: 961  RLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRR 1020
            RLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRR
Sbjct: 961  RLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRR 1020

Query: 1021 RRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF 1080
            RRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF
Sbjct: 1021 RRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF 1080

Query: 1081 PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEP 1140
            PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEP
Sbjct: 1081 PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEP 1140

Query: 1141 DTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGR 1200
            DTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGR
Sbjct: 1141 DTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGR 1200

Query: 1201 KPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNS 1260
            KPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNS
Sbjct: 1201 KPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNS 1260

Query: 1261 PETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDED 1320
            PETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDED
Sbjct: 1261 PETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDED 1320

Query: 1321 DGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSH 1380
            DGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSH
Sbjct: 1321 DGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSH 1380

Query: 1381 DTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHE 1440
            DTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHE
Sbjct: 1381 DTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHE 1440

Query: 1441 GAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSP 1500
            GAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSP
Sbjct: 1441 GAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSP 1500

Query: 1501 NVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTT 1560
            NVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTT
Sbjct: 1501 NVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTT 1560

Query: 1561 ENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQ 1620
            ENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQ
Sbjct: 1561 ENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQ 1620

Query: 1621 QSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQ 1680
            QSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQ
Sbjct: 1621 QSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQ 1680

Query: 1681 QQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFG 1740
            QQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFG
Sbjct: 1681 QQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFG 1740

Query: 1741 AGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPL 1800
            AGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPL
Sbjct: 1741 AGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPL 1800

Query: 1801 AGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSK 1860
            AGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSK
Sbjct: 1801 AGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSK 1860

Query: 1861 SAPLPSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLN 1920
            SAPLPSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLN
Sbjct: 1861 SAPLPSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLN 1920

Query: 1921 AMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYTG 1980
            AMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYTG
Sbjct: 1921 AMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYTG 1980

Query: 1981 PSHHSYMNAAGVPKQSLNGPYMRR 2004
            PSHHSYMNAAGVPKQSLNGPYMRR
Sbjct: 1981 PSHHSYMNAAGVPKQSLNGPYMRR 2004


>gi|150378493 MYST histone acetyltransferase (monocytic leukemia) 3
            [Homo sapiens]
          Length = 2004

 Score = 4073 bits (10562), Expect = 0.0
 Identities = 2004/2004 (100%), Positives = 2004/2004 (100%)

Query: 1    MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTI 60
            MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTI
Sbjct: 1    MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTI 60

Query: 61   LKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQNVDWNKLIKRAVEGLAESGGSTLKS 120
            LKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQNVDWNKLIKRAVEGLAESGGSTLKS
Sbjct: 61   LKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQNVDWNKLIKRAVEGLAESGGSTLKS 120

Query: 121  IERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE 180
            IERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
Sbjct: 121  IERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE 180

Query: 181  SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPS 240
            SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPS
Sbjct: 181  SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPS 240

Query: 241  CLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRM 300
            CLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRM
Sbjct: 241  CLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRM 300

Query: 301  PKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP 360
            PKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
Sbjct: 301  PKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP 360

Query: 361  GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPS 420
            GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPS
Sbjct: 361  GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPS 420

Query: 421  PDGRKARGEVVDYSEQYRIRKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGSQEIMTEK 480
            PDGRKARGEVVDYSEQYRIRKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGSQEIMTEK
Sbjct: 421  PDGRKARGEVVDYSEQYRIRKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGSQEIMTEK 480

Query: 481  DMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC 540
            DMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
Sbjct: 481  DMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC 540

Query: 541  EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLF 600
            EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLF
Sbjct: 541  EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLF 600

Query: 601  LDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGR 660
            LDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGR
Sbjct: 601  LDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGR 660

Query: 661  FLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT 720
            FLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
Sbjct: 661  FLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT 720

Query: 721  GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVI 780
            GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVI
Sbjct: 721  GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVI 780

Query: 781  VSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAP 840
            VSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAP
Sbjct: 781  VSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAP 840

Query: 841  VSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG 900
            VSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG
Sbjct: 841  VSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG 900

Query: 901  ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKC 960
            ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKC
Sbjct: 901  ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKC 960

Query: 961  RLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRR 1020
            RLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRR
Sbjct: 961  RLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRR 1020

Query: 1021 RRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF 1080
            RRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF
Sbjct: 1021 RRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF 1080

Query: 1081 PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEP 1140
            PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEP
Sbjct: 1081 PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEP 1140

Query: 1141 DTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGR 1200
            DTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGR
Sbjct: 1141 DTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGR 1200

Query: 1201 KPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNS 1260
            KPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNS
Sbjct: 1201 KPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNS 1260

Query: 1261 PETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDED 1320
            PETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDED
Sbjct: 1261 PETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDED 1320

Query: 1321 DGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSH 1380
            DGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSH
Sbjct: 1321 DGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSH 1380

Query: 1381 DTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHE 1440
            DTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHE
Sbjct: 1381 DTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHE 1440

Query: 1441 GAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSP 1500
            GAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSP
Sbjct: 1441 GAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSP 1500

Query: 1501 NVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTT 1560
            NVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTT
Sbjct: 1501 NVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTT 1560

Query: 1561 ENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQ 1620
            ENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQ
Sbjct: 1561 ENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQ 1620

Query: 1621 QSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQ 1680
            QSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQ
Sbjct: 1621 QSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQ 1680

Query: 1681 QQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFG 1740
            QQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFG
Sbjct: 1681 QQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFG 1740

Query: 1741 AGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPL 1800
            AGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPL
Sbjct: 1741 AGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPL 1800

Query: 1801 AGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSK 1860
            AGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSK
Sbjct: 1801 AGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSK 1860

Query: 1861 SAPLPSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLN 1920
            SAPLPSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLN
Sbjct: 1861 SAPLPSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLN 1920

Query: 1921 AMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYTG 1980
            AMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYTG
Sbjct: 1921 AMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYTG 1980

Query: 1981 PSHHSYMNAAGVPKQSLNGPYMRR 2004
            PSHHSYMNAAGVPKQSLNGPYMRR
Sbjct: 1981 PSHHSYMNAAGVPKQSLNGPYMRR 2004


>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
            [Homo sapiens]
          Length = 2073

 Score = 1310 bits (3390), Expect = 0.0
 Identities = 780/1596 (48%), Positives = 969/1596 (60%), Gaps = 249/1596 (15%)

Query: 463  KQENEE-RLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHT 521
            KQE+ +  + G+++++TE+D+++F+  QE + +K+      +   R PSVIEFGKYEI T
Sbjct: 673  KQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQT 732

Query: 522  WYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEV 581
            WYSSPYPQEY+RLPKLYLCEFCLKYMKS+ IL +H KKCGWFHPPANEIYR+ ++SVFEV
Sbjct: 733  WYSSPYPQEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEV 792

Query: 582  DGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQK 641
            DGN+S IYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLT+ND KGCHLVGYFSKEK CQQK
Sbjct: 793  DGNMSKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQK 852

Query: 642  YNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILE 701
            YNVSCIMI+PQ+QR+G+GRFLIDFSYLLS+REGQAGSPEKPLSDLGRLSY+AYWKSVILE
Sbjct: 853  YNVSCIMIMPQHQRQGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILE 912

Query: 702  CLYHQNDKQISIKKLSKLTGICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQ 761
             LYH +++ ISIK +S+ TG+CP DI +TL HL M+D R  +FVIIRREKLI  HM KL+
Sbjct: 913  YLYHHHERHISIKAISRATGMCPHDIATTLQHLHMIDKRDGRFVIIRREKLILSHMEKLK 972

Query: 762  LNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGEN--EEPQCQERELEISVGKSVSH 819
               R  ++DP+ LRWTP+++SN+ VSEEE E  +E E   E+  C E+E           
Sbjct: 973  TCSRANELDPDSLRWTPILISNAAVSEEEREAEKEAERLMEQASCWEKE----------- 1021

Query: 820  ENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERF 879
               EQ+  S  +  +    +P      +K +   +S P   +   RG+            
Sbjct: 1022 ---EQEILSTRANSR---QSPAKVQSKNKYLHSPESRPVTGE---RGQ------------ 1060

Query: 880  GDKDSKLLLEETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRR 939
                   LLE +  + +E+  E  E+ E  +E+  E EE+    EE+  ++     P R 
Sbjct: 1061 -------LLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSPPRL 1113

Query: 940  LSEGVEPWRGQLK-KSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEP-ESP 997
                 +P    +K K P  LK       +R  +R            SE++E   EP ++ 
Sbjct: 1114 ----TKPQSVAIKRKRPFVLK------KKRGRKRRRINSSVTTETISETTEVLNEPFDNS 1163

Query: 998  RSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERP 1057
                P    +PT + +     R+  +RK   H                            
Sbjct: 1164 DEERPMPQLEPTCEIEVEEDGRKPVLRKAFQH---------------------------- 1195

Query: 1058 MPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDAD 1117
                +P  +   EEEE  +N  F                      K+ D   +  +DD+ 
Sbjct: 1196 ----QPGKKRQTEEEEGKDNHCF----------------------KNADPCRNNMNDDSS 1229

Query: 1118 DTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSR 1177
            +           K   K++P       PLK K+ WPKG  R    W++   RK GFKL+ 
Sbjct: 1230 NL----------KEGSKDNP------EPLKCKQVWPKGTKRGLSKWRQNKERKTGFKLNL 1273

Query: 1178 EIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEA-EEA 1236
               P +     +EP         +  ++E +ET E K   P P   +EE +   EA    
Sbjct: 1274 YTPPETP----MEP-------DEQVTVEEQKETSEGKTS-PSPIRIEEEVKETGEALLPQ 1321

Query: 1237 EEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQ------ 1290
            EE   E+  +   P  SP +    PE +  +PE EEEEE+    EE+ +  EE+      
Sbjct: 1322 EENRREETCAPVSPNTSPGE---KPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNV 1378

Query: 1291 ---------QELEEPE-------------PEEEEDAAAETAQNDDHDADDEDDGHLESTK 1328
                     QE EEPE              EEEE+   E + N+DHDADDEDD H+ES  
Sbjct: 1379 EKDPDGAKSQEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESA- 1437

Query: 1329 KKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELD------SEEEQPSHDT 1382
            + E EE P RE  KE    QE+FLD N+Q      +   +  +D      SE ++ + D 
Sbjct: 1438 EVEKEELP-RESFKEVLENQETFLDLNVQPGHSNPEVLMDCGVDLTASCNSEPKELAGDP 1496

Query: 1383 SVV----SEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSE 1438
              V     E   G +   ++  ++KE   E KE       E+D ETVQAVQSLTQ ESSE
Sbjct: 1497 EAVPESDEEPPPGEQAQKQDQKNSKEVDTEFKEGNPAT-MEIDSETVQAVQSLTQ-ESSE 1554

Query: 1439 HEGAYQDCEETLAACQTLQSYTQADEDPQM-SMVEDCHASEHNSPISSVQSHPSQSVRSV 1497
             +  +QDC ET  AC++LQ+YT+AD+ PQ+ + ++DC  S+H+SP+SSV SHP QSVRSV
Sbjct: 1555 QDDTFQDCAETQEACRSLQNYTRADQSPQIATTLDDCQQSDHSSPVSSVHSHPGQSVRSV 1614

Query: 1498 SSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIE 1557
            +SP+VPALE+ Y QISP+Q ++S PS+QNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIE
Sbjct: 1615 NSPSVPALENSYAQISPDQSAISVPSLQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIE 1674

Query: 1558 STTENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCS 1617
            STTENYENPSSYDSTMGGSICGN SSQ+SCSY  L +SSSLTQSSC VTQQM+++  SCS
Sbjct: 1675 STTENYENPSSYDSTMGGSICGNGSSQNSCSYSNL-TSSSLTQSSCAVTQQMSNISGSCS 1733

Query: 1618 MMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQ 1677
            M+QQ+S+     CS+KSPQ CVVERPPS+ QQ                            
Sbjct: 1734 MLQQTSISSPPTCSVKSPQGCVVERPPSSSQQ---------------------------- 1765

Query: 1678 QPQQQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERI-P 1736
                                    L+QCSM  +FTP   + EIPE+ S  NI +YER+  
Sbjct: 1766 ------------------------LAQCSMAANFTPPMQLAEIPET-SNANIGLYERMGQ 1800

Query: 1737 GDFGAGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVS----LSNTGLA 1792
             DFGAG Y QPSATFSLAKLQQLTNT++D H++PYSHS AVTSYA S S    LSNTGL 
Sbjct: 1801 SDFGAGHYPQPSATFSLAKLQQLTNTLID-HSLPYSHSAAVTSYANSASLSTPLSNTGLV 1859

Query: 1793 QLAPS-HPLAGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPV 1851
            QL+ S H + G PQAQATMTPPPNL    MNL  PLLQ NM+A+NIGI H+QRLQ Q+  
Sbjct: 1860 QLSQSPHSVPGGPQAQATMTPPPNLTPPPMNLPPPLLQRNMAASNIGISHSQRLQTQIAS 1919

Query: 1852 KGHISIRSKSAPL-PSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMGVNLMPTPAYN 1910
            KGHIS+R+KSA L P+AA HQ Q+YGRS   VAMQ   R L +QRGMNM VNLMP PAYN
Sbjct: 1920 KGHISMRTKSASLSPAAATHQSQIYGRS-QTVAMQGPARTLTMQRGMNMSVNLMPAPAYN 1978

Query: 1911 VNS--MNMNTLNAMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPM 1968
            VNS  MNMNTLNAMN Y M+QPMMNS YHSN  YMNQT QYPMQMQMGMMG+Q Y QQPM
Sbjct: 1979 VNSVNMNMNTLNAMNGYSMSQPMMNSGYHSNHGYMNQTPQYPMQMQMGMMGTQPYAQQPM 2038

Query: 1969 QPNPHGNMMYTGPSHHSYMNAAGVPKQSLNGPYMRR 2004
            Q  PHGNMMYT P HH YMN  G+ KQSLNG YMRR
Sbjct: 2039 QTPPHGNMMYTAPGHHGYMN-TGMSKQSLNGSYMRR 2073



 Score =  602 bits (1553), Expect = e-172
 Identities = 302/476 (63%), Positives = 365/476 (76%), Gaps = 31/476 (6%)

Query: 1   MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTI 60
           MVKLANPLYTEWILEAI+K+KKQKQRPSEERIC+AVS+SHGLD+KTV EQLELSV+DG++
Sbjct: 1   MVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSV 60

Query: 61  LKVSNKGLNSYKDPDNPGRIALPKPR--------NHGKLDNKQNVDWNKLIKRAVEGLAE 112
           LKV+NKGL SYKDPDNPGR +  KP         + G  ++ +NVDWNKL++RA+EGL E
Sbjct: 61  LKVTNKGLASYKDPDNPGRFSSVKPGTFPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEE 120

Query: 113 SGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTK 172
             GS+LK+IE++L+ Q D+++     A   F Q+LRL  KRA+ +GRLLKDGP YR+N  
Sbjct: 121 PNGSSLKNIEKYLRSQSDLTSTTNNPA---FQQRLRLGAKRAVNNGRLLKDGPQYRVNYG 177

Query: 173 ATNVDGKESCESL--SCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISC 230
           + +  G     S   S LPPVSLLPHEKD+P A+PIPICSFCLGTKE NREKKPEEL+SC
Sbjct: 178 SLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSC 237

Query: 231 ADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHM 290
           ADCG+SGHPSCLKF PELT  VKALRWQCIECKTCS+CR QG+NADNMLFCDSCDRGFHM
Sbjct: 238 ADCGSSGHPSCLKFCPELTTNVKALRWQCIECKTCSACRVQGRNADNMLFCDSCDRGFHM 297

Query: 291 ECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQ---NT 347
           ECCDPPL+RMPKGMWICQ+CRP+KKGRKLL +KAAQIKRRY  PIGRPKN+LK++    T
Sbjct: 298 ECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVT 357

Query: 348 VSKGPFSKV--RTGPGRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRD---------- 395
             +G  +    R  PGRG+K K+  +  S  ++S +    R+   D  R           
Sbjct: 358 SDEGSMNAFTGRGSPGRGQKTKVCTTPSSGHAASGKDSSSRLAVTDPTRPGATTKITTTS 417

Query: 396 ---SNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSS 448
              S  +LK NKKTKGLIDGLTKFFTPSPDGR++RGE++D+S+ YR RK+ ++K S
Sbjct: 418 TYISASTLKVNKKTKGLIDGLTKFFTPSPDGRRSRGEIIDFSKHYRPRKKVSQKQS 473


>gi|5901962 MYST histone acetyltransferase 2 [Homo sapiens]
          Length = 611

 Score =  365 bits (937), Expect = e-100
 Identities = 175/309 (56%), Positives = 230/309 (74%), Gaps = 4/309 (1%)

Query: 474 QEIMTEKDMELFRDIQEQA---LQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQE 530
           + + +E D++LFR  Q +A   L+K+ + G           I FG+YE+ TWY SPYP+E
Sbjct: 299 ENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEE 358

Query: 531 YSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYC 590
           Y+RL +LY+CEFCLKYMKS+TIL++HM KC W HPP +EIYRK +ISVFEVDG  + IYC
Sbjct: 359 YARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYC 418

Query: 591 QNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMIL 650
           QNLCLLAKLFLDHKTLYYDVEPFLFYV+T+ D  GCHL+GYFSKEK+    YNVSCI+ +
Sbjct: 419 QNLCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTM 478

Query: 651 PQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQ 710
           PQY R+GYG+ LIDFSYLLSK E + GSPE+PLSDLG +SY +YWK V+L  L++   K+
Sbjct: 479 PQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKE 538

Query: 711 ISIKKLSKLTGICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAK-LQLNLRPVDV 769
           ISIK++S+ T + P DI STL  L+ML +   + ++++R+ LI + +AK  + +     +
Sbjct: 539 ISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWIAKEAKRSNSNKTM 598

Query: 770 DPECLRWTP 778
           DP CL+WTP
Sbjct: 599 DPSCLKWTP 607


>gi|226371636 MYST histone acetyltransferase 1 isoform 1 [Homo
           sapiens]
          Length = 458

 Score =  315 bits (808), Expect = 2e-85
 Identities = 152/274 (55%), Positives = 189/274 (68%), Gaps = 1/274 (0%)

Query: 505 QVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFH 564
           +V+    I  G YEI  WY SP+P++Y + PKL+LCE+CLKYMK     + H+ +C W  
Sbjct: 175 KVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQ 234

Query: 565 PPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVK 624
           PP  EIYRK+NISV+EVDG    IYCQNLCLLAKLFLDHKTLY+DVEPF+FY+LT+ D +
Sbjct: 235 PPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQ 294

Query: 625 GCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLS 684
           G H+VGYFSKEK      NV+CI+ LP YQR+GYG+FLI FSY LSK E   GSPEKPLS
Sbjct: 295 GAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLS 354

Query: 685 DLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLTGICPQDITSTLHHLRMLDFRSDQF 744
           DLG+LSY +YW  V+LE L       +SIK LS++T I   DI STL  L M+ +   Q 
Sbjct: 355 DLGKLSYRSYWSWVLLEIL-RDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQH 413

Query: 745 VIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTP 778
           VI    KL+++H+   Q    P+ VD  CL+W P
Sbjct: 414 VICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAP 447


>gi|36287069 K(lysine) acetyltransferase 5 isoform 1 [Homo sapiens]
          Length = 546

 Score =  303 bits (777), Expect = 9e-82
 Identities = 147/273 (53%), Positives = 191/273 (69%), Gaps = 9/273 (3%)

Query: 512 IEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIY 571
           IE G++ +  WY SPYPQE + LP LYLCEFCLKY +S   LQ+H+ KC   HPP NEIY
Sbjct: 268 IELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIY 327

Query: 572 RKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGY 631
           RK  IS FE+DG  +  Y QNLCLLAK FLDHKTLYYD +PFLFYV+T+ D KG H+VGY
Sbjct: 328 RKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGY 387

Query: 632 FSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSY 691
           FSKEK   + YNV+CI+ LP YQR+GYG+ LI+FSY LSK EG+ G+PEKPLSDLG LSY
Sbjct: 388 FSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSY 447

Query: 692 MAYWKSVILECLYHQNDK-----QISIKKLSKLTGICPQDITSTLHHLRMLDFRSDQFVI 746
            +YW   ILE L     +     QI+I ++S++T I  +D+ STL +L ++++   Q+++
Sbjct: 448 RSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYIL 507

Query: 747 IRREKLIQDH-MAKLQLNLRPVDVDPECLRWTP 778
              E ++  H  A L+  LR   +D +CL +TP
Sbjct: 508 TLSEDIVDGHERAMLKRLLR---IDSKCLHFTP 537


>gi|36287060 K(lysine) acetyltransferase 5 isoform 3 [Homo sapiens]
          Length = 461

 Score =  303 bits (777), Expect = 9e-82
 Identities = 147/273 (53%), Positives = 191/273 (69%), Gaps = 9/273 (3%)

Query: 512 IEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIY 571
           IE G++ +  WY SPYPQE + LP LYLCEFCLKY +S   LQ+H+ KC   HPP NEIY
Sbjct: 183 IELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIY 242

Query: 572 RKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGY 631
           RK  IS FE+DG  +  Y QNLCLLAK FLDHKTLYYD +PFLFYV+T+ D KG H+VGY
Sbjct: 243 RKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGY 302

Query: 632 FSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSY 691
           FSKEK   + YNV+CI+ LP YQR+GYG+ LI+FSY LSK EG+ G+PEKPLSDLG LSY
Sbjct: 303 FSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSY 362

Query: 692 MAYWKSVILECLYHQNDK-----QISIKKLSKLTGICPQDITSTLHHLRMLDFRSDQFVI 746
            +YW   ILE L     +     QI+I ++S++T I  +D+ STL +L ++++   Q+++
Sbjct: 363 RSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYIL 422

Query: 747 IRREKLIQDH-MAKLQLNLRPVDVDPECLRWTP 778
              E ++  H  A L+  LR   +D +CL +TP
Sbjct: 423 TLSEDIVDGHERAMLKRLLR---IDSKCLHFTP 452


>gi|36287049 K(lysine) acetyltransferase 5 isoform 2 [Homo sapiens]
          Length = 513

 Score =  303 bits (777), Expect = 9e-82
 Identities = 147/273 (53%), Positives = 191/273 (69%), Gaps = 9/273 (3%)

Query: 512 IEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIY 571
           IE G++ +  WY SPYPQE + LP LYLCEFCLKY +S   LQ+H+ KC   HPP NEIY
Sbjct: 235 IELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIY 294

Query: 572 RKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGY 631
           RK  IS FE+DG  +  Y QNLCLLAK FLDHKTLYYD +PFLFYV+T+ D KG H+VGY
Sbjct: 295 RKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGY 354

Query: 632 FSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSY 691
           FSKEK   + YNV+CI+ LP YQR+GYG+ LI+FSY LSK EG+ G+PEKPLSDLG LSY
Sbjct: 355 FSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSY 414

Query: 692 MAYWKSVILECLYHQNDK-----QISIKKLSKLTGICPQDITSTLHHLRMLDFRSDQFVI 746
            +YW   ILE L     +     QI+I ++S++T I  +D+ STL +L ++++   Q+++
Sbjct: 415 RSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYIL 474

Query: 747 IRREKLIQDH-MAKLQLNLRPVDVDPECLRWTP 778
              E ++  H  A L+  LR   +D +CL +TP
Sbjct: 475 TLSEDIVDGHERAMLKRLLR---IDSKCLHFTP 504


>gi|226371638 MYST histone acetyltransferase 1 isoform 2 [Homo
           sapiens]
          Length = 467

 Score =  300 bits (769), Expect = 7e-81
 Identities = 146/263 (55%), Positives = 182/263 (69%), Gaps = 1/263 (0%)

Query: 505 QVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFH 564
           +V+    I  G YEI  WY SP+P++Y + PKL+LCE+CLKYMK     + H+ +C W  
Sbjct: 175 KVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQ 234

Query: 565 PPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVK 624
           PP  EIYRK+NISV+EVDG    IYCQNLCLLAKLFLDHKTLY+DVEPF+FY+LT+ D +
Sbjct: 235 PPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQ 294

Query: 625 GCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLS 684
           G H+VGYFSKEK      NV+CI+ LP YQR+GYG+FLI FSY LSK E   GSPEKPLS
Sbjct: 295 GAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLS 354

Query: 685 DLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLTGICPQDITSTLHHLRMLDFRSDQF 744
           DLG+LSY +YW  V+LE L       +SIK LS++T I   DI STL  L M+ +   Q 
Sbjct: 355 DLGKLSYRSYWSWVLLEIL-RDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQH 413

Query: 745 VIIRREKLIQDHMAKLQLNLRPV 767
           VI    KL+++H+   Q    P+
Sbjct: 414 VICVTPKLVEEHLKSAQYKKPPI 436


>gi|205830434 D4, zinc and double PHD fingers family 1 isoform c
           [Homo sapiens]
          Length = 332

 Score =  137 bits (345), Expect = 1e-31
 Identities = 68/151 (45%), Positives = 88/151 (58%), Gaps = 10/151 (6%)

Query: 179 KESCESLSCLPPVSLLPHEKDKPVAEPIP--ICSFCLGTKEQNREKKPEELISCADCGNS 236
           K+  + L+ +P        K  P    IP   C FCLG  ++     PE+LISCADCG S
Sbjct: 187 KQFYKELAWVPEAQRKHTAKKAPDGTVIPNGYCDFCLGGSKKTG--CPEDLISCADCGRS 244

Query: 237 GHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPP 296
           GHPSCL+F+  +T  V+  RWQCIECK+CS C    +N D +LFCD CDRG+HM C  PP
Sbjct: 245 GHPSCLQFTVNMTAAVRTYRWQCIECKSCSLC-GTSENDDQLLFCDDCDRGYHMYCLSPP 303

Query: 297 LTRMPKGMWICQICRPRKKGRKLLQKKAAQI 327
           +   P+G W C +C      R L +K +A I
Sbjct: 304 MAEPPEGSWSCHLCL-----RHLKEKASAYI 329


>gi|205830430 D4, zinc and double PHD fingers family 1 isoform a
           [Homo sapiens]
          Length = 414

 Score =  137 bits (345), Expect = 1e-31
 Identities = 68/151 (45%), Positives = 88/151 (58%), Gaps = 10/151 (6%)

Query: 179 KESCESLSCLPPVSLLPHEKDKPVAEPIP--ICSFCLGTKEQNREKKPEELISCADCGNS 236
           K+  + L+ +P        K  P    IP   C FCLG  ++     PE+LISCADCG S
Sbjct: 269 KQFYKELAWVPEAQRKHTAKKAPDGTVIPNGYCDFCLGGSKKTG--CPEDLISCADCGRS 326

Query: 237 GHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPP 296
           GHPSCL+F+  +T  V+  RWQCIECK+CS C    +N D +LFCD CDRG+HM C  PP
Sbjct: 327 GHPSCLQFTVNMTAAVRTYRWQCIECKSCSLC-GTSENDDQLLFCDDCDRGYHMYCLSPP 385

Query: 297 LTRMPKGMWICQICRPRKKGRKLLQKKAAQI 327
           +   P+G W C +C      R L +K +A I
Sbjct: 386 MAEPPEGSWSCHLCL-----RHLKEKASAYI 411


>gi|5454004 D4, zinc and double PHD fingers family 2 [Homo sapiens]
          Length = 391

 Score =  136 bits (342), Expect = 2e-31
 Identities = 57/110 (51%), Positives = 75/110 (68%), Gaps = 2/110 (1%)

Query: 202 VAEPIPICSFCLGTKEQNREK-KPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCI 260
           +A P   C FCLG  + N++  +PEEL+SC+DCG SGHPSCL+F+P +   VK  RWQCI
Sbjct: 266 LALPNNYCDFCLGDSKINKKTGQPEELVSCSDCGRSGHPSCLQFTPVMMAAVKTYRWQCI 325

Query: 261 ECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQIC 310
           ECK C+ C    +N D +LFCD CDRG+HM C  P ++  P+G W C +C
Sbjct: 326 ECKCCNIC-GTSENDDQLLFCDDCDRGYHMYCLTPSMSEPPEGSWSCHLC 374


>gi|205830432 D4, zinc and double PHD fingers family 1 isoform b
           [Homo sapiens]
          Length = 380

 Score =  130 bits (327), Expect = 1e-29
 Identities = 66/156 (42%), Positives = 85/156 (54%), Gaps = 18/156 (11%)

Query: 183 ESLSCLPPVSLLPHEKDKPVAEPIP--ICSFCLGTKEQNREKKPEELISCADCGNSGHPS 240
           + L+ +P        K  P    IP   C FCLG  ++     PE+LISCADCG SGHPS
Sbjct: 229 KELAWVPEAQRKHTAKKAPDGTVIPNGYCDFCLGGSKKTG--CPEDLISCADCGRSGHPS 286

Query: 241 CLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNA---------DNMLFCDSCDRGFHME 291
           CL+F+  +T  V+  RWQCIECK+CS C     +          D +LFCD CDRG+HM 
Sbjct: 287 CLQFTVNMTAAVRTYRWQCIECKSCSLCGTSENDGASWAGLTPQDQLLFCDDCDRGYHMY 346

Query: 292 CCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQI 327
           C  PP+   P+G W C +C      R L +K +A I
Sbjct: 347 CLSPPMAEPPEGSWSCHLCL-----RHLKEKASAYI 377


>gi|194328736 PHD finger protein 10 isoform b [Homo sapiens]
          Length = 496

 Score =  122 bits (307), Expect = 3e-27
 Identities = 59/124 (47%), Positives = 72/124 (58%), Gaps = 8/124 (6%)

Query: 200 KPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQC 259
           KP   P  IC  CL  KE N++ K E LI C+ C NSGHPSCL  + EL   +K   WQC
Sbjct: 369 KPKVIPNAICGICLKGKESNKKGKAESLIHCSQCENSGHPSCLDMTMELVSMIKTYPWQC 428

Query: 260 IECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICR-----PRK 314
           +ECKTC  C  Q  + + M+FCD CDRG+H  C    L  +P G WIC  C+     PRK
Sbjct: 429 MECKTCIIC-GQPHHEEEMMFCDMCDRGYHTFCVG--LGAIPSGRWICDCCQRAPPTPRK 485

Query: 315 KGRK 318
            GR+
Sbjct: 486 VGRR 489


>gi|194328734 PHD finger protein 10 isoform a [Homo sapiens]
          Length = 498

 Score =  122 bits (307), Expect = 3e-27
 Identities = 59/124 (47%), Positives = 72/124 (58%), Gaps = 8/124 (6%)

Query: 200 KPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQC 259
           KP   P  IC  CL  KE N++ K E LI C+ C NSGHPSCL  + EL   +K   WQC
Sbjct: 371 KPKVIPNAICGICLKGKESNKKGKAESLIHCSQCENSGHPSCLDMTMELVSMIKTYPWQC 430

Query: 260 IECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICR-----PRK 314
           +ECKTC  C  Q  + + M+FCD CDRG+H  C    L  +P G WIC  C+     PRK
Sbjct: 431 MECKTCIIC-GQPHHEEEMMFCDMCDRGYHTFCVG--LGAIPSGRWICDCCQRAPPTPRK 487

Query: 315 KGRK 318
            GR+
Sbjct: 488 VGRR 491


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
            [Homo sapiens]
          Length = 899

 Score = 91.3 bits (225), Expect = 9e-18
 Identities = 138/700 (19%), Positives = 288/700 (41%), Gaps = 62/700 (8%)

Query: 752  LIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEE---EEEEAEEGEN------EEP 802
            L +   +++QLN++ +    E  ++    V  + + EE   +EEE  E E       E+ 
Sbjct: 236  LAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 295

Query: 803  QCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQP 862
              QE  L    GK    E K         E++ E+       R  K++   +      Q 
Sbjct: 296  WRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEE-QMQEQE 354

Query: 863  SRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEATQEQYTESEEQLVA 922
             +      K R+ +E+   ++ +L  +E     QEQ     E+    Q++    +E+ + 
Sbjct: 355  EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR 414

Query: 923  SEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLR 982
             +E+  +  +    ++++ E  +  R Q +K  E  + R  E   R            ++
Sbjct: 415  EQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQ 474

Query: 983  GFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETT 1042
               E+  E+EE E  +   P          +K  L  + ++++++        E I E  
Sbjct: 475  KQEENMWEQEEKEWQQQRLP---------EQKEKLWEQEKMQEQE--------EKIWEQE 517

Query: 1043 EVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQD--VLRCQSSS 1100
            E + +  E    E+ M R E   ++ E+E++  E E   R+  +++  Q+  + +     
Sbjct: 518  EKIRDQEEMWGQEKKMWRQE---KMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQ 574

Query: 1101 KRKSKDEEE---DEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKS 1157
            ++K+ D+EE   +EE     +  + +   ++R+++ K    E +     +++K W + + 
Sbjct: 575  EKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQ--EQEEKMQEQEEKMWEQEEK 632

Query: 1158 RKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDM 1217
             +    K     +  ++   ++          E +    K   + K+QE EE +  +E M
Sbjct: 633  MQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKM 692

Query: 1218 PLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKP 1277
                E+K +E+ +   ++ +  EEE     E             +   +E  + E+EEK 
Sbjct: 693  ----EKKTQEQEKKTWDQEKMREEESMRERE------------KKMREEEEMMREQEEKM 736

Query: 1278 RVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPT 1337
            +  EE+ Q +EE+   +E +  E+E+   E  +  +      +   ++  +K   +E+  
Sbjct: 737  QEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKM 796

Query: 1338 REDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSV--VSEQMAGSEDD 1395
            R+  ++  G +E      M+   EK++ +EE     EE+    +  +    E+M G E+ 
Sbjct: 797  RDQEEKMRGQEE-----KMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEK 851

Query: 1396 HEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEE 1435
             EE    +EE  +++E+EE    + +    Q  +   QEE
Sbjct: 852  MEEKMQGQEE--KMREQEEKMRGQEEKMREQEEKMRGQEE 889



 Score = 82.4 bits (202), Expect = 4e-15
 Identities = 142/704 (20%), Positives = 291/704 (41%), Gaps = 70/704 (9%)

Query: 772  ECLRWTPV-IVSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVE 830
            +  R +P+  VS S++  E ++ A    +      E +  +S   +VS  +K+ D Y  E
Sbjct: 145  QAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALS---AVSTRHKKADRYIEE 201

Query: 831  SEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEE 890
              K+ + +    S  L +  + ++ L   +   +      ++ K++ +   K+ K  LE 
Sbjct: 202  LTKERDAL----SLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLER 257

Query: 891  TSSA-PQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRG 949
                 PQ Q     E+    +E+  E E+++   EE+  +       + RL E     R 
Sbjct: 258  AKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQ------EERLREQEGKMRE 311

Query: 950  QLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPT 1009
            Q +K     K RL E  + L  +  E     LR   E  E+EE+ +              
Sbjct: 312  QEEKMWRQEK-RLREQEKELREQEKE-----LREQKELREQEEQMQ-------------- 351

Query: 1010 LKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDE 1069
             ++++    +  ++R+++            +  ++ ++  +  D E  M      +E DE
Sbjct: 352  -EQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERM------WEQDE 404

Query: 1070 EEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEE---DEESDDADDTPILKPVS 1126
               E++E      + + ++      +     ++K++D+EE   +EE     +  + +   
Sbjct: 405  RLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEE 464

Query: 1127 LLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQA 1186
             +R+++ K    E +     +K+    +   +K   W++   ++   K+  +   +  Q 
Sbjct: 465  TMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQE 524

Query: 1187 CVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERK---EEEEMQAEAEEAEEG---- 1239
               E      K  R+ K++E E+ +  +E+    +E+K   +EE M+ + +E E+     
Sbjct: 525  ---EMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQ 581

Query: 1240 -----EEEDAASSEVPAASPADSSNSPETETKEPE--VEEEEEKPRVSEEQRQSEEEQQ- 1291
                 EEE     E       +     E + +E E  ++E+EEK    EE+ Q +EE+  
Sbjct: 582  EEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMW 641

Query: 1292 ELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESF 1351
            E EE   E+EE    +    +  +   E +   E  K +E EE+   ++  E+   ++  
Sbjct: 642  EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEK 701

Query: 1352 LDANMQKSREKIKDKE-ETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIE-- 1408
               + +K RE+   +E E ++  EEE        + EQ    ++  EE    +E++ E  
Sbjct: 702  KTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQE 761

Query: 1409 --LKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETL 1450
              + E++ +P  +  L   + +Q   QE+  E E   +D EE +
Sbjct: 762  EKMWEQQRLPEQKEKLWEHEKMQE--QEKIWEQEEKMRDQEEKM 803



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 124/669 (18%), Positives = 262/669 (39%), Gaps = 85/669 (12%)

Query: 783  NSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVS 842
            N++ +EE +++  E + + P  +  + EI +         E+  + +     P+V     
Sbjct: 216  NTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLL-----PQVQTNTL 270

Query: 843  STRLSKQV--LPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG 900
               + +Q   L         Q  +  R   + R+ + +  +++ K+  +E     QE+  
Sbjct: 271  QEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKEL 330

Query: 901  ECGEKSEATQEQYTESEEQLVASEEQP--------SQDGKPDLPKRRLSEGVEPWRGQLK 952
               EK    Q++  E EEQ+   EE+          Q+ K    + RL E  +  R Q +
Sbjct: 331  REQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 390

Query: 953  KSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKR 1012
            K  +  + R+ E  ERL R   E  R   + + +  +  EE +           +  ++ 
Sbjct: 391  KMRDQEE-RMWEQDERL-REKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQE 448

Query: 1013 KKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEE 1072
            ++    R +++R+ +        ET+ E  E + +  E+               + E+EE
Sbjct: 449  EERIREREKKMREEE--------ETMREQEEKMQKQEEN---------------MWEQEE 485

Query: 1073 EEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRD 1132
            +E + +  P E   +L  Q+ ++ Q     + +++  D+E     +  + +   +   R+
Sbjct: 486  KEWQQQRLP-EQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKM---RE 541

Query: 1133 VKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPI 1192
             ++   E +     +++K W +                       E M   TQ       
Sbjct: 542  QEDQMWEQEEKMRDQEQKMWDQ----------------------EERMEKKTQE------ 573

Query: 1193 VSIPKAGRKPKIQESEETVEPKEDMPLPEER-KEEEEMQAEAEEAEEGEEEDAASSEVPA 1251
                   ++ K  + EE +  +E M   E++ +EEEEM  E EE  + +EE     E   
Sbjct: 574  -------QEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKM 626

Query: 1252 ASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEE-----EQQELEEPEPEEEEDAAA 1306
                +     E +  E E +  E++ ++ E+QR  E+     E ++++E E  +E++   
Sbjct: 627  WEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKI 686

Query: 1307 ETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDK 1366
               +  +    +++    +  K +E E    RE    E        +  MQ+  EK++++
Sbjct: 687  WEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQ 746

Query: 1367 EETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQ 1426
            EE   + EE+    +  +  +Q    + +   +    +E  ++ E+EE    + +    Q
Sbjct: 747  EEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQ 806

Query: 1427 AVQSLTQEE 1435
              +   QEE
Sbjct: 807  EEKMRGQEE 815



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 56/239 (23%), Positives = 100/239 (41%), Gaps = 12/239 (5%)

Query: 1221 EERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVE--EEEEKPR 1278
            EE +E+E+   + EE    +EE     E       +     E   +E E E  E+E++ R
Sbjct: 279  EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELR 338

Query: 1279 VSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTR 1338
              +E R+ EE+ QE EE   E+EE         +  +     +  L   +K+  E++   
Sbjct: 339  EQKELREQEEQMQEQEEKMWEQEEK------MREQEEKMWRQEERLWEQEKQMREQEQKM 392

Query: 1339 EDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEE 1398
             D +E    Q+  L    ++ RE+ K  E+ E   EE++         +Q    E+  +E
Sbjct: 393  RDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQ----EEKMQE 448

Query: 1399 DSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQ 1457
            +   +E   +++EEEE    + +    Q      QEE    +    + +E L   + +Q
Sbjct: 449  EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ 507



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 96/505 (19%), Positives = 198/505 (39%), Gaps = 59/505 (11%)

Query: 788  EEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLS 847
            E++  + EE   EE + +ERE ++   +    E +E+       +K+ E M         
Sbjct: 436  EKKTRDQEEKMQEEERIREREKKMREEEETMREQEEK------MQKQEENMWEQEEKEWQ 489

Query: 848  KQVLPHDSLPANSQPSRRGR----WGRKNR-KTQERFGDKDSKLLLEETSSAPQEQYGEC 902
            +Q LP        Q   + +    W ++ + + QE    ++ K+  +E     ++Q  E 
Sbjct: 490  QQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ 549

Query: 903  GEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRL 962
             EK    +++  + EE++    ++  +       K R  E +     ++++  E ++   
Sbjct: 550  EEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR--- 606

Query: 963  TEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRR 1022
             E  E++     E +  +     +  E+EE+ +           K   + +K +  +R  
Sbjct: 607  -EQEEKM----QEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661

Query: 1023 VRKRK--HHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEED--ENE 1078
             +K K   H      E + E  E + E  ++   ++   + + T++ ++  EEE   E E
Sbjct: 662  EQKEKLWEHEKMQEQEKMQEQEEKIWE--QEKMEKKTQEQEKKTWDQEKMREEESMRERE 719

Query: 1079 LFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPL 1138
               RE    +  Q+  + Q   ++  + EEE  E ++       K     R  + K    
Sbjct: 720  KKMREEEEMMREQEE-KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 778

Query: 1139 EPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKA 1198
            E +     +++K W + +  +    K R G++   +   E M    +             
Sbjct: 779  EHEKMQ--EQEKIWEQEEKMRDQEEKMR-GQEEKMRGQEEKMRGQEEKMW---------- 825

Query: 1199 GRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSS 1258
            G++ K+   EE +  +E+    +E K EE+MQ + E+  E EE                 
Sbjct: 826  GQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEE----------------- 868

Query: 1259 NSPETETKEPEVEEEEEKPRVSEEQ 1283
               +   +E ++ E+EEK R  EE+
Sbjct: 869  ---KMRGQEEKMREQEEKMRGQEEK 890



 Score = 35.4 bits (80), Expect = 0.57
 Identities = 34/155 (21%), Positives = 62/155 (40%), Gaps = 9/155 (5%)

Query: 788 EEE--EEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTR 845
           EEE  E+E +  E EE   +++ L     K   HE  ++     E E+K          +
Sbjct: 747 EEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQ 806

Query: 846 LSKQVLPHDSLPANSQP---SRRGRWGRKNRK--TQERFGDKDSKLLLEETSSAPQEQYG 900
             K     + +    +         WG++ +    +E+   ++ K+  EE     +E+  
Sbjct: 807 EEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKM--EEKMQGQEEKMR 864

Query: 901 ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDL 935
           E  EK    +E+  E EE++   EE+    G P +
Sbjct: 865 EQEEKMRGQEEKMREQEEKMRGQEEKIYCVGSPPI 899


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 119/577 (20%), Positives = 239/577 (41%), Gaps = 40/577 (6%)

Query: 882  KDSKLLLEETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLS 941
            +++++  E T    +E   E G++ E  +E+  E  E+   ++  P+++     P++   
Sbjct: 462  EETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEE--ETKSPPAEEAAS--PEK--- 514

Query: 942  EGVEPWRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSS 1001
            E   P + + K   EA      E       +  E  ++  +  ++S  E + PE   + S
Sbjct: 515  EAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKS 574

Query: 1002 PPILTKPTLKRKKPFLHRRRRVRKRK--HHNSSVVTETISETTEVLDEPFEDSDSERPMP 1059
            P  +  P  K K P     +   + K      S V E      E      E++ S   + 
Sbjct: 575  PAEVKSPE-KAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVK 633

Query: 1060 RLEPTFEIDEEEEEEDENELFPREYFRRL--SSQDVLRCQSSSKRKSKDEEEDE-ESDDA 1116
              E      +EE +  E    P +   +    ++  ++ ++ S  K+K   + E +S + 
Sbjct: 634  SPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEK 693

Query: 1117 DDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLS 1176
              +P+ +     +  +   SP++ +  +P K K   P  +  K     K P ++      
Sbjct: 694  AKSPVKEEA---KSPEKAKSPVKEEAKSPEKAKS--PVKEEAKTPEKAKSPVKEEAKSPE 748

Query: 1177 REIMPVSTQAC-VIEPIVSIP--KAGRKPKIQESEETVEP-KEDMPLPEERKEEEEMQAE 1232
            +   P   +   V  P    P  +  R P  +  E+   P KE++  PE+ K   +  A+
Sbjct: 749  KAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAK 808

Query: 1233 AEEAEEGEEEDAASSEVPAASPADSSNSP-ETETKEPEVEEEEEK----PRVSEEQRQSE 1287
            A E E  ++E+         SP      P E + KEP  + EEEK    P+  E++   +
Sbjct: 809  APEKEIPKKEE-------VKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKK 861

Query: 1288 EEQQELEEPEP--EEEEDAAAETAQNDDHDA---DDEDDGHLESTKKKELEEQPTREDVK 1342
            EE  + E P+P  EE+++ A E  +    +A   + ED   + + +K+   +   +ED K
Sbjct: 862  EEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAK 921

Query: 1343 EEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHT 1402
             +   + +  + +  K++E  K  E+ E   E++    + +   E+   +E   +ED  T
Sbjct: 922  PKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKT 981

Query: 1403 -KEELIELKEEEEIPHSELDLETVQAVQSLTQEESSE 1438
              +E  + K E+    S  D +  +  +  T++++++
Sbjct: 982  LSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAK 1018



 Score = 86.3 bits (212), Expect = 3e-16
 Identities = 140/648 (21%), Positives = 252/648 (38%), Gaps = 107/648 (16%)

Query: 784  SVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSS 843
            +V+ EE+ EE +  E E  + +E+E +   GK      +E+     E  K P      S 
Sbjct: 454  TVIVEEQTEETQVTE-EVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASP 512

Query: 844  TRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECG 903
             + +K  +  +   A S    +     + +   E    + +K   +E + +P E      
Sbjct: 513  EKEAKSPVKEE---AKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEK 569

Query: 904  EKSEATQEQYTESEEQLVASEE--QPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCR 961
            E++++  E  +  + +  A EE   P++   P+  K  + E          KSP   K  
Sbjct: 570  EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEA--------KSPAEAKSP 621

Query: 962  LTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRR 1021
            + E   + P      ++A     S + EE + PE  +S        P  K K P     +
Sbjct: 622  VKE-EAKSPAEVKSPEKAK----SPTKEEAKSPEKAKSPEKEEAKSPE-KAKSPVKAEAK 675

Query: 1022 RVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFP 1081
               K K   S V  E  +++ E    P ++ +++ P     P     +EE +  E    P
Sbjct: 676  SPEKAK---SPVKAE--AKSPEKAKSPVKE-EAKSPEKAKSPV----KEEAKSPEKAKSP 725

Query: 1082 REYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEPD 1141
             +             ++  K KS  +EE +  + A      K     +  DVK+    P+
Sbjct: 726  VKE----------EAKTPEKAKSPVKEEAKSPEKA------KSPEKAKTLDVKS----PE 765

Query: 1142 TSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRK 1201
              TP K++   P  K                        P   ++ V E +    K+  K
Sbjct: 766  AKTPAKEEARSPADK-----------------------FPEKAKSPVKEEV----KSPEK 798

Query: 1202 PKIQESEETVEPKEDMPLPEE-----RKEEEEMQAEAEEAEEGEEEDAASSEVPAASPAD 1256
             K    E+   P++++P  EE     ++EE+  + + +E  +  EE+ A +        D
Sbjct: 799  AKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKD 858

Query: 1257 S--SNSPETETKEPEVEEEE----EKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQ 1310
            S    +P+ E  +P+VEE++    EKP+ S+ + + EE + + + P PE+E  A  E  +
Sbjct: 859  SKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKE 918

Query: 1311 NDDHDADDE------DDGHLESTKK--KELEEQPTREDVKEEPGVQESFLDANMQKSREK 1362
            +       E      DD   +   K  ++ E  P ++D KEE   +         K+  K
Sbjct: 919  DAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPE----EKPKTEAK 974

Query: 1363 IKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELK 1410
             K+ ++T L  E  +P       +E+   S    ++DS   E+  E K
Sbjct: 975  AKEDDKT-LSKEPSKPK------AEKAEKSSSTDQKDSKPPEKATEDK 1015



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 121/564 (21%), Positives = 224/564 (39%), Gaps = 60/564 (10%)

Query: 786  VSEEEEEEAEE--------GENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKP-- 835
            V+EEEE+EA+E        GE EE +  E E +    +  +   KE  S   E  K P  
Sbjct: 470  VTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAE 529

Query: 836  -------EVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLL 888
                   E  +P       K   P     A S P  +     + +   E    + +K   
Sbjct: 530  AKSPEKEEAKSPAEVKSPEKAKSPAKE-EAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPA 588

Query: 889  EETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEE--QPSQDGKPDLPKRRLSEGVEP 946
            +E + +P E       KS   +E  + +E +    EE   P++   P+  K    E  E 
Sbjct: 589  KEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKE--EA 646

Query: 947  WRGQLKKSPEALKCRLTEGSE---RLPRRYSEGDRAVLRGFSESSEE-----EEEPESPR 998
               +  KSPE  + +  E ++   +   +  E  ++ ++  ++S E+     +EE +SP 
Sbjct: 647  KSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPE 706

Query: 999  SSSPPIL--TKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETIS-------ETTEVLDEPF 1049
             +  P+    K   K K P     +   K K   S V  E  S       E  + LD   
Sbjct: 707  KAKSPVKEEAKSPEKAKSPVKEEAKTPEKAK---SPVKEEAKSPEKAKSPEKAKTLDVKS 763

Query: 1050 EDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEE 1109
             ++ +        P  +  E+ +   + E+   E  +    +D    +    +K + +  
Sbjct: 764  PEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSP 823

Query: 1110 DEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPL-KKKKGWPKGKSRKPIHWKKRPG 1168
             +E +   +  + +P    +K + + +P  P T      KK+  PK ++ KP   K    
Sbjct: 824  VKEEEKPQEVKVKEPP---KKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKP---KVEEK 877

Query: 1169 RKPGFKLSREIMPVSTQACVIEPIVSIPKAGRK-PKIQESEETVEPKEDMPLPEERKEEE 1227
            ++P  +  +E   V  +    E    +P   ++ P   E +E  +PKE   + ++  ++ 
Sbjct: 878  KEPAVEKPKE-SKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDA 936

Query: 1228 EMQAEAEEAEEGEE--EDAASSEVPAASPADSSNSPETETKEPE----VEEEEEKPRVSE 1281
            + +  ++ AE+ E   E   + E  A  P +    P+TE K  E    + +E  KP+  +
Sbjct: 937  KAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEK---PKTEAKAKEDDKTLSKEPSKPKAEK 993

Query: 1282 EQRQSEEEQQELEEPEPEEEEDAA 1305
             ++ S  +Q++ + PE   E+ AA
Sbjct: 994  AEKSSSTDQKDSKPPEKATEDKAA 1017



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 113/517 (21%), Positives = 199/517 (38%), Gaps = 93/517 (17%)

Query: 1197 KAGRKPKIQES--EETV---EPKEDMPLPEERKEEEEMQAEAEEAEE---GEEEDAASSE 1248
            K+  K K+ E   +ETV   E  E+  + EE  EEEE +A+ EE +E   GEEE+A   E
Sbjct: 439  KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE 498

Query: 1249 VPAASP-ADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAE 1307
                SP A+ + SPE E K P V+EE + P    +  + EE +   E   PE+ +  A E
Sbjct: 499  EETKSPPAEEAASPEKEAKSP-VKEEAKSP-AEAKSPEKEEAKSPAEVKSPEKAKSPAKE 556

Query: 1308 TAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKD-- 1365
             A                  K     + P +E+ K    V          KS EK K   
Sbjct: 557  EA------------------KSPPEAKSPEKEEAKSPAEV----------KSPEKAKSPA 588

Query: 1366 KEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETV 1425
            KEE +  +E + P    S V E+   ++   E  S  KEE            S  ++++ 
Sbjct: 589  KEEAKSPAEAKSPEKAKSPVKEE---AKSPAEAKSPVKEE----------AKSPAEVKSP 635

Query: 1426 QAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQAD-EDPQMSMVEDCHASEHNSPIS 1484
            +  +S T+EE+   E A    +E   + +  +S  +A+ + P+ +       ++      
Sbjct: 636  EKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAK 695

Query: 1485 SVQSHPSQSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQ 1544
            S     ++S     SP     +S     SP +     P       SP+ +     + ++ 
Sbjct: 696  SPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAK---SPVKEEAKSPEKAKS 752

Query: 1545 VVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCV 1604
               +   D+ S E+ T   E   S                         +     ++   
Sbjct: 753  PEKAKTLDVKSPEAKTPAKEEARS------------------------PADKFPEKAKSP 788

Query: 1605 VTQQMASMGSSCSMMQQSSVQPAANCSIK-----------SPQSCVVERPPSNQQQQPPP 1653
            V +++ S   + S +++ +  P      K            PQ   V+ PP   +++  P
Sbjct: 789  VKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAP 848

Query: 1654 PPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQP 1690
              P+  +    + + AP+   P+ + +++ +P  ++P
Sbjct: 849  ATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKP 885



 Score = 71.6 bits (174), Expect = 7e-12
 Identities = 91/460 (19%), Positives = 171/460 (37%), Gaps = 70/460 (15%)

Query: 1025 KRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREY 1084
            K K      V E   + T +++E  E++         + T E+ EEEE+E + E      
Sbjct: 437  KVKSEEKIKVVEKSEKETVIVEEQTEET---------QVTEEVTEEEEKEAKEE------ 481

Query: 1085 FRRLSSQDVLRCQSSSKRKSKDEE--EDEESDDADDTPILKPVSLLRKRDVKNSPLEPDT 1142
                              + K+EE  E+EE++  ++             + K+ P E + 
Sbjct: 482  ------------------EGKEEEGGEEEEAEGGEE-------------ETKSPPAE-EA 509

Query: 1143 STPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKP 1202
            ++P K+ K   K +++ P    K P ++     +    P   ++   E   S P+A + P
Sbjct: 510  ASPEKEAKSPVKEEAKSPAE-AKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA-KSP 567

Query: 1203 KIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEE--EDAASSEVPAASPADSSNS 1260
            + +E++   E K         KEE +  AEA+  E+ +   ++ A S   A SP      
Sbjct: 568  EKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAK 627

Query: 1261 PETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPE----PEEEEDAAAETAQNDDHDA 1316
               E K PE  +   K      ++    E++E + PE    P + E  + E A++     
Sbjct: 628  SPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVK-- 685

Query: 1317 DDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEE 1376
                       K  E  + P +E+ K     +    +      + K   KEE +   + +
Sbjct: 686  --------AEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAK 737

Query: 1377 QPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEES 1436
             P  + +   E+    E     D  + E     KEE   P  +   +    V+   +   
Sbjct: 738  SPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPE 797

Query: 1437 SEHEGAYQDC---EETLAACQTLQSYTQADEDPQMSMVED 1473
                   +D    E+ +   + ++S  + +E PQ   V++
Sbjct: 798  KAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 116/548 (21%), Positives = 209/548 (38%), Gaps = 63/548 (11%)

Query: 983  GFSESSEEEEEPES--PRSSSPPI--LTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETI 1038
            G  E   EEEE E     + SPP      P  + K P     +   + K    S   E  
Sbjct: 483  GKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAK----SPEKEEA 538

Query: 1039 SETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLR-CQ 1097
                EV   P +     +   +  P  +  E+EE +   E+   E  +  + ++     +
Sbjct: 539  KSPAEV-KSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAE 597

Query: 1098 SSSKRKSKDEEEDEESDDAD-DTPI---LKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWP 1153
            + S  K+K   ++E    A+  +P+    K  + ++  +   SP + +  +P K K   P
Sbjct: 598  AKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKS--P 655

Query: 1154 KGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEP 1213
            + +  K     K P +       +   PV  +A          K+  K K    EE   P
Sbjct: 656  EKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEA----------KSPEKAKSPVKEEAKSP 705

Query: 1214 -KEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEE 1272
             K   P+ EE K  E+ ++  +E  +  E+  +  +  A SP + + SPE + K  +V+ 
Sbjct: 706  EKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSP-EKAKSPE-KAKTLDVKS 763

Query: 1273 EEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKEL 1332
             E K    EE R   ++  E +   P +EE  + E A++            L+   K   
Sbjct: 764  PEAKTPAKEEARSPADKFPE-KAKSPVKEEVKSPEKAKSP-----------LKEDAKAPE 811

Query: 1333 EEQPTRED----VKEEPGVQESFLDANMQKSRE-------KIKDKEETELDSEEEQPSHD 1381
            +E P +E+    VKEE   QE  +    +K+ E       K ++K++++ +   ++ +  
Sbjct: 812  KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPK 871

Query: 1382 TSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEG 1441
              V  ++    E   E     K+E  E K++   P  E   + V+  +    +E +E   
Sbjct: 872  PKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAK-VEVKEDAKPKEKTEVAK 930

Query: 1442 AYQD----------CEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPS 1491
               D           E+  AA +   +  +  + P+     +  A E +  +S   S P 
Sbjct: 931  KEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPK 990

Query: 1492 QSVRSVSS 1499
                  SS
Sbjct: 991  AEKAEKSS 998


>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
            sapiens]
          Length = 1362

 Score = 88.6 bits (218), Expect = 6e-17
 Identities = 118/539 (21%), Positives = 201/539 (37%), Gaps = 81/539 (15%)

Query: 1201 KPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNS 1260
            KPK +E ++  + KE     EE +E ++ +A+    ++ ++ ++++S V    PA   + 
Sbjct: 535  KPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSK 594

Query: 1261 PETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDD----HDA 1316
            P   T E E EE++ KP   EE+RQ   +  +L    P E+        Q+ +    +  
Sbjct: 595  PPP-TYESE-EEDKCKPMSYEEKRQLSLDINKL----PGEKLGRVVHIIQSREPSLKNSN 648

Query: 1317 DDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEE 1376
             DE +   E+ K   L E              E ++ + ++K R+   +K +    S + 
Sbjct: 649  PDEIEIDFETLKPSTLREL-------------ERYVTSCLRKKRKPQAEKVDVIAGSSKM 695

Query: 1377 QPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEES 1436
            +        SE  + SE    +   ++ E+    +++  P                +E+ 
Sbjct: 696  KGFSS----SESESSSESSSSDSEDSETEMAPKSKKKGHPG---------------REQK 736

Query: 1437 SEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVRS 1496
              H   +Q  ++  A              P     +     +   P     S P Q+  +
Sbjct: 737  KHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQ----QQPPPPPPPPSMPQQAAPA 792

Query: 1497 VSSPNVPALESGYTQISPE-QGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSG------ 1549
            + S   P + +    + P+  GS+  P     +    +  P +  H  Q  +        
Sbjct: 793  MKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLN 852

Query: 1550 ----FSDLGSIESTTENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVV 1605
                 S      +  +    PS+  + +        +   + +   L     + Q   V+
Sbjct: 853  QHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVL 912

Query: 1606 TQQ-------MASMGSSCSMMQQSSVQPAA----NCSIKSPQSCVVERPP-----SNQQQ 1649
             +        + SM     + Q   VQP      +  ++S     +  PP        QQ
Sbjct: 913  LEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQ 972

Query: 1650 QPPPPPPQQPQPPPPQPQPAPQPPPPQQQP-------QQQPQPQPQQPPPPPPPQQQPP 1701
            QPPPPPP QPQ PPPQ Q  P P P   QP       QQ P PQ QQPP PPP QQ PP
Sbjct: 973  QPPPPPPPQPQ-PPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPP 1030



 Score = 75.9 bits (185), Expect = 4e-13
 Identities = 71/234 (30%), Positives = 95/234 (40%), Gaps = 52/234 (22%)

Query: 1647 QQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCS 1706
            Q QQ P P PQQP PPP QP P   PPPPQQQ         QQPPPPPPP   P  +  +
Sbjct: 745  QMQQAPAPVPQQPPPPPQQPPP---PPPPQQQ---------QQPPPPPPPPSMPQQAAPA 792

Query: 1707 MNNSFTPAPMI-MEIPESGSTGNISIYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMD 1765
            M +S  P P I  ++P        S+++ I      G ++QP        +  L    + 
Sbjct: 793  MKSS--PPPFIATQVPVLEPQLPGSVFDPI------GHFTQP--------ILHLPQPELP 836

Query: 1766 PH-AMPYSHS--PAVTSYATSVSLSNTGLAQLAPSHPLAGTPQAQATMTPPPNLASTTMN 1822
            PH   P  HS  P +  +A    +S   L    P  P   + +A A    P    + +  
Sbjct: 837  PHLPQPPEHSTPPHLNQHAV---VSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPA 893

Query: 1823 LT-SPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSKSAPLPSAAAHQQQLY 1875
            LT +PLL                 Q  M     + +  +  P P   + Q QLY
Sbjct: 894  LTQTPLLP----------------QPPMAQPPQVLLEDEEPPAPPLTSMQMQLY 931



 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 68/258 (26%), Positives = 99/258 (38%), Gaps = 28/258 (10%)

Query: 1640 VERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPPPPPPPQQQ 1699
            +++ P+   QQPPPPP Q P PPPPQ Q  P PPPP     QQ  P  +  PPP    Q 
Sbjct: 746  MQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQV 805

Query: 1700 PPLSQCSMNNSFTP----APMIMEIPESGSTGNISIYERIPGDFGAGSYSQPSATFSLAK 1755
            P L      + F P       I+ +P+      +  +   P +     +    A  S   
Sbjct: 806  PVLEPQLPGSVFDPIGHFTQPILHLPQP----ELPPHLPQPPEHSTPPHLNQHAVVSPPA 861

Query: 1756 LQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQ--LAPSHPLAGTPQAQATMTPP 1813
            L    N +    + P + + A+          +  L Q  L P  P+A  PQ       P
Sbjct: 862  LH---NALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEP 918

Query: 1814 PNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSK---SAPLPSAAAH 1870
            P    T+M +   L Q             Q++Q   P+   + ++S+     P P   + 
Sbjct: 919  PAPPLTSMQMQLYLQQ------------LQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSV 966

Query: 1871 QQQLYGRSPSAVAMQAGP 1888
            QQQL  + P     Q  P
Sbjct: 967  QQQLQQQPPPPPPPQPQP 984



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 116/559 (20%), Positives = 210/559 (37%), Gaps = 77/559 (13%)

Query: 1190 EPIVSIPKAGRKP--KIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASS 1247
            EP+V++      P  K+     + +   D     +   ++  +  A+   E +E+  A  
Sbjct: 463  EPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVH 522

Query: 1248 EVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEE------- 1300
            E  AA      N P+ + K+ + +++E+  R  E +   E ++ + +EP P++       
Sbjct: 523  EQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVE---ENKKSKAKEPPPKKTKKNNSS 579

Query: 1301 ------EEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTRE---DVKEEPGVQESF 1351
                  +E A  ++     +++++ED       K K +  +  R+   D+ + PG +   
Sbjct: 580  NSNVSKKEPAPMKSKPPPTYESEEED-------KCKPMSYEEKRQLSLDINKLPGEKLGR 632

Query: 1352 LDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKE 1411
            +   +Q     +K+    E++ + E     T    E+   S          K+   + ++
Sbjct: 633  VVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTS-------CLRKKRKPQAEK 685

Query: 1412 EEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMV 1471
             + I  S      ++   S   E SSE   +  +  ET  A ++ +      E  +    
Sbjct: 686  VDVIAGSS----KMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHH 741

Query: 1472 EDCHASEHNSPISSVQSHPSQSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSP 1531
                  +  +P+      P Q       P  P  +       P   S+   +   M++SP
Sbjct: 742  HHQQMQQAPAPVPQQPPPPPQQ----PPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSP 797

Query: 1532 MMDVPS-VSDHSQQVVDSGFSDLGSIESTTENY---ENPSSYDSTMGGSICGNSSSQSSC 1587
               + + V     Q+  S F  +G       +    E P         S   + +  +  
Sbjct: 798  PPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAVV 857

Query: 1588 SYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQ 1647
            S   L ++  L Q     + + A++    +  +  +V PA   +   PQ  + + P    
Sbjct: 858  SPPALHNA--LPQQPSRPSNRAAALPPKPA--RPPAVSPALTQTPLLPQPPMAQPPQVLL 913

Query: 1648 QQQPPPPPP-------------QQPQPPPP---------QPQPAPQPPPPQQQPQQQPQP 1685
            + + PP PP             Q+ QPP P         QP P P PPPP    QQQ Q 
Sbjct: 914  EDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPP-PLPPPPHPSVQQQLQ- 971

Query: 1686 QPQQPPPPPPPQQQPPLSQ 1704
              QQPPPPPPPQ QPP  Q
Sbjct: 972  --QQPPPPPPPQPQPPPQQ 988



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 33/89 (37%), Positives = 37/89 (41%), Gaps = 6/89 (6%)

Query: 1643 PPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQQQP-----QPQPQQPPPPPPPQ 1697
            P + Q   PP     QP PPP Q  P P P        Q P      PQP Q PPP PPQ
Sbjct: 197  PNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQ 256

Query: 1698 QQPPLSQCSMNNSFTPAPMIMEIPESGST 1726
             QPP +         P P+I   P+   T
Sbjct: 257  PQPPPAPAPQPVQSHP-PIIAATPQPVKT 284



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 29/77 (37%), Positives = 30/77 (38%), Gaps = 18/77 (23%)

Query: 1635 PQSCVVERPPSNQQQQPPPPPPQQPQPP------------------PPQPQPAPQPPPPQ 1676
            P +     PP  Q  QP PPP Q    P                  PPQP   P P PPQ
Sbjct: 197  PNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQ 256

Query: 1677 QQPQQQPQPQPQQPPPP 1693
             QP   P PQP Q  PP
Sbjct: 257  PQPPPAPAPQPVQSHPP 273



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 24/49 (48%), Positives = 26/49 (53%), Gaps = 1/49 (2%)

Query: 1645 SNQQQQPPPPPPQQP-QPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPPP 1692
            S   QQPPPP  QQP  PPP Q  P PQP  PQQ  Q    P+  +  P
Sbjct: 1005 STHIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDP 1053



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 38/122 (31%), Positives = 49/122 (40%), Gaps = 30/122 (24%)

Query: 1617 SMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPP------------PQQPQP--- 1661
            S+ QQ   QP        P      +PP  QQ QPPP P             Q P P   
Sbjct: 965  SVQQQLQQQPP-------PPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQ 1017

Query: 1662 PPPQPQPAPQPPPPQ-QQPQQQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEI 1720
             PP P P  QPPPPQ  +PQQ  Q         P   +  P S   +  +  P+P+++  
Sbjct: 1018 QPPHPPPGQQPPPPQPAKPQQVIQHHHS-----PRHHKSDPYSTGHLREA--PSPLMIHS 1070

Query: 1721 PE 1722
            P+
Sbjct: 1071 PQ 1072



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 61/285 (21%), Positives = 123/285 (43%), Gaps = 31/285 (10%)

Query: 1035 TETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVL 1094
            +++ S+++   D   +DS+ ER   RL    E  +   E+      P++   +   +D  
Sbjct: 486  SDSSSDSSSDSDSSTDDSEEERAQ-RLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKK 544

Query: 1095 RCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPK 1154
              +   K K K+E E+ +   A + P  K     +K +  NS +      P+K K   P 
Sbjct: 545  E-KKKEKHKRKEEVEENKKSKAKEPPPKKT----KKNNSSNSNVSKKEPAPMKSKPP-PT 598

Query: 1155 GKSR-----KPIHWKKRP------GRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPK 1203
             +S      KP+ ++++        + PG KL R +  + ++    EP +   K     +
Sbjct: 599  YESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSR----EPSL---KNSNPDE 651

Query: 1204 IQESEETVEPKEDMPLPEE----RKEEEEMQAEAEEAEEGEEE--DAASSEVPAASPADS 1257
            I+   ET++P     L        +++ + QAE  +   G  +    +SSE  ++S + S
Sbjct: 652  IEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSS 711

Query: 1258 SNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEE 1302
            S+S ++ET+     +++  P   +++      QQ  + P P  ++
Sbjct: 712  SDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQ 756



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 60/299 (20%), Positives = 121/299 (40%), Gaps = 45/299 (15%)

Query: 1088 LSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVK-NSPL---EPDTS 1143
            + S  + + QS + +    +    +  +     +++P  L+  ++ K +SP+   EP + 
Sbjct: 1068 IHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSP 1127

Query: 1144 TPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIV-SIPKAGRKP 1202
            +   +    P+   + P+H  +RP          E+ PV     VI P   + P  G   
Sbjct: 1128 SLRPEPPKHPES-IKAPVHLPQRP----------EMKPVDVGRPVIRPPEQNAPPPGAPD 1176

Query: 1203 KIQESEET---VEPKEDMPL----------------PEERKEE-----EEMQAEAEEAEE 1238
            K ++ +E    V PK+D+ +                P    +      E+ +  A E EE
Sbjct: 1177 KDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEE 1236

Query: 1239 GEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEP 1298
             E+   A +E  A    +        ++E E   E+ +    E +R+ E++QQ+ +E + 
Sbjct: 1237 REKALKAQAE-HAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQ 1295

Query: 1299 EEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQ 1357
            ++++ AAA  A         +    L+  +++EL  +  RE  +       + +D N Q
Sbjct: 1296 QQQQQAAAVAAAATPQAQSSQPQSMLD--QQRELARK--REQERRRREAMAATIDMNFQ 1350



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 30/102 (29%), Positives = 39/102 (38%), Gaps = 23/102 (22%)

Query: 1640 VERPPSNQQQQPPPPPP-QQPQPP-PPQPQPAPQ---------------------PPPPQ 1676
            +++PP  Q QQPP PPP QQP PP P +PQ   Q                     P P  
Sbjct: 1008 IQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLM 1067

Query: 1677 QQPQQQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIM 1718
                Q  Q Q      PP    QP   +    +   P P+++
Sbjct: 1068 IHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVV 1109



 Score = 38.9 bits (89), Expect = 0.051
 Identities = 55/284 (19%), Positives = 108/284 (38%), Gaps = 40/284 (14%)

Query: 889  EETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKP--DLPKRRLSEGVEP 946
            + +S +  +      +  E   ++  E +EQL A  EQ +   +P  + PK++  +  E 
Sbjct: 487  DSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEK 546

Query: 947  WRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILT 1006
             + + K+  E  + + ++  E  P++  + +       S S+  ++EP   +S  PP   
Sbjct: 547  KKEKHKRKEEVEENKKSKAKEPPPKKTKKNNS------SNSNVSKKEPAPMKSKPPPTYE 600

Query: 1007 KPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFE 1066
                 + KP  +  +  R+     + +  E +     ++        S  P  +     E
Sbjct: 601  SEEEDKCKPMSYEEK--RQLSLDINKLPGEKLGRVVHII-------QSREPSLKNSNPDE 651

Query: 1067 IDEEEEEEDENELFPREYF--------RRLSSQDVLRCQSSSKRKSKDEEEDEESDDADD 1118
            I+ + E    + L   E +        R+  ++ V     SSK K     E E S ++  
Sbjct: 652  IEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSS 711

Query: 1119 TPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIH 1162
            +            D ++S  E     P  KKKG P  + +K  H
Sbjct: 712  S------------DSEDSETE---MAPKSKKKGHPGREQKKHHH 740



 Score = 38.1 bits (87), Expect = 0.087
 Identities = 34/111 (30%), Positives = 40/111 (36%), Gaps = 42/111 (37%)

Query: 1632 IKSPQSCVVERPPSNQQQQPPPPPPQQPQPPP-PQPQPAPQPPP-----PQQ-------- 1677
            +++P   VV  PP  Q  Q PPP P QPQPPP P PQP    PP     PQ         
Sbjct: 234  VQTPVMTVV--PP--QPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVK 289

Query: 1678 -----------QPQQQPQPQPQQP-------------PPPPPPQQQPPLSQ 1704
                        P  +P   P +P             P  PP +  P   Q
Sbjct: 290  RKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQ 340



 Score = 36.2 bits (82), Expect = 0.33
 Identities = 25/99 (25%), Positives = 38/99 (38%), Gaps = 6/99 (6%)

Query: 1631 SIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQP----- 1685
            ++  PQ      P   Q Q PP P PQ  Q  PP     PQP   ++  +++        
Sbjct: 240  TVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTT 299

Query: 1686 -QPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPES 1723
              P   PP  PP+ +         +S    P   ++P+S
Sbjct: 300  IDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDS 338



 Score = 33.5 bits (75), Expect = 2.1
 Identities = 34/131 (25%), Positives = 54/131 (41%), Gaps = 26/131 (19%)

Query: 1621 QSSVQPAAN----CSIKSPQSCVV---ERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPP 1673
            Q +VQP        S+  PQ  VV   E+  S   +  P  P  +P+PP   P+    P 
Sbjct: 1086 QQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPK-HPESIKAPV 1144

Query: 1674 PPQQQPQQQP--------QPQPQQPPPPPPP-----QQQP-----PLSQCSMNNSFTPAP 1715
               Q+P+ +P        +P  Q  PPP  P     +Q+P     P     + N  + A 
Sbjct: 1145 HLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWAS 1204

Query: 1716 MIMEIPESGST 1726
            ++ + P + S+
Sbjct: 1205 LVQKHPTTPSS 1215



 Score = 31.6 bits (70), Expect = 8.2
 Identities = 54/278 (19%), Positives = 99/278 (35%), Gaps = 55/278 (19%)

Query: 1036 ETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDEN------ELFPREYFRRLS 1089
            + + E    L +P ++   ++   + E   E  + +EE +EN      E  P++  +  S
Sbjct: 519  KAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNS 578

Query: 1090 SQDVLRCQSSSKRKSKDEE--EDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLK 1147
            S   +  +  +  KSK     E EE D        KP+S   KR +         S  + 
Sbjct: 579  SNSNVSKKEPAPMKSKPPPTYESEEEDKC------KPMSYEEKRQL---------SLDIN 623

Query: 1148 KKKGWPKGK------SRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRK 1201
            K  G   G+      SR+P      P      ++  E +  ST   +   + S  +  RK
Sbjct: 624  KLPGEKLGRVVHIIQSREPSLKNSNPDE---IEIDFETLKPSTLRELERYVTSCLRKKRK 680

Query: 1202 PKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASS-------------- 1247
            P+  E  + +     M      + E   ++ + ++E+ E E A  S              
Sbjct: 681  PQA-EKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHH 739

Query: 1248 --------EVPAASPADSSNSPETETKEPEVEEEEEKP 1277
                    + PA  P      P+     P  +++++ P
Sbjct: 740  HHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPP 777


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo
            sapiens]
          Length = 916

 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 105/455 (23%), Positives = 185/455 (40%), Gaps = 41/455 (9%)

Query: 989  EEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEP 1048
            EE++E    +   P    +    +K P       V++ +        E   E  E  DE 
Sbjct: 486  EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEE---EEGQEEEEEEDEG 542

Query: 1049 FEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEE 1108
             +   +E      E + E +E E+EE E E          +  +    +   K + K EE
Sbjct: 543  AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAE--------AEGEEAEAKEEKKVEEKSEE 594

Query: 1109 EDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPG 1168
               + +   D  + KP     K  V  SP+E    +P+ K     KGKS  P    +  G
Sbjct: 595  VATKEELVADAKVEKPEKA--KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 652

Query: 1169 RKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEE 1228
            + P  K      PV  +         + +  + P  +   E  + K ++   E+++EEE+
Sbjct: 653  KSPVPK-----SPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK 707

Query: 1229 MQAEAEEAEEGEEEDAASSEVPAASPADSSNSPE------TETKEPEVE-EEEEKPRVSE 1281
               EA + E+ E+++    +VP    A+S    E      T TK  +V  E+E K     
Sbjct: 708  EVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKP 767

Query: 1282 EQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTRE-- 1339
             Q++ E+E+   E    EE  D  A+ ++ +D   + E +G       KE  EQ T+E  
Sbjct: 768  LQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEG-------KEEVEQETKEKG 820

Query: 1340 -DVKEEPGVQESFLD---ANMQKSREKIKDK---EETELDSEEEQPSHDTSVVSEQMAGS 1392
               +EE GV  + LD   A+ +K  +K ++K    +T      E     T  +++ +  +
Sbjct: 821  SGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVT 880

Query: 1393 EDDHEEDSHTKEELIELKEEEEIPHSELDLETVQA 1427
            +   E +   +E+L+  K+ E++    +  E  Q+
Sbjct: 881  QKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQS 915



 Score = 81.3 bits (199), Expect = 9e-15
 Identities = 115/509 (22%), Positives = 195/509 (38%), Gaps = 88/509 (17%)

Query: 984  FSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTE 1043
            F E   EE + E  +S     LT  T +        ++   + K        E ++    
Sbjct: 452  FVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKS 511

Query: 1044 VLDEPFEDSDSERPMPRLEPTFEIDEEEEE--------------EDENELFPREYFRRLS 1089
             +     +   E      E   E +EEE+E              E  +E    E     +
Sbjct: 512  PVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGET 571

Query: 1090 SQDVLRCQSSSKRKSKDEEEDEE----SDDADDTPILKPVSLLRKRDVKNSPLEPDTSTP 1145
              +    ++ +K + K EE+ EE     +   D  + KP     K  V  SP+E    +P
Sbjct: 572  EAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEK--AKSPVPKSPVEEKGKSP 629

Query: 1146 LKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQ 1205
            + K     KGKS  P    +  G+ P                   P   + + G+ P   
Sbjct: 630  VPKSPVEEKGKSPVPKSPVEEKGKSP------------------VPKSPVEEKGKSP--- 668

Query: 1206 ESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETET 1265
             S+  VE K   P+P+   EE + +AE  + E+ EEE+    E P               
Sbjct: 669  VSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAP--------------- 713

Query: 1266 KEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLE 1325
            KE +VE++EEKP+   E++++E             +E+A AE               HLE
Sbjct: 714  KEEKVEKKEEKPKDVPEKKKAES----------PVKEEAVAEVV-----TITKSVKVHLE 758

Query: 1326 STKKKE---LEEQPTREDVKEEPGVQESFLDANMQKSRE-------KIKDKEETELDSEE 1375
               K+E   L+++  +E    E G +E   D   + SR+       +++ KEE E +++E
Sbjct: 759  KETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKE 818

Query: 1376 EQP--SHDTSVVSEQMAGSEDDHEEDSHTKEE-LIELKEEEEIPHSELDLETVQAVQSLT 1432
            +      +  VV+  +  S  D ++     EE ++  K  E+I     D  T    +S+T
Sbjct: 819  KGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVT 878

Query: 1433 -QEESSEHEGAYQDCEETLAACQTLQSYT 1460
              ++  EHE  +   EE L + + ++  T
Sbjct: 879  VTQKVEEHEETF---EEKLVSTKKVEKVT 904



 Score = 68.2 bits (165), Expect = 8e-11
 Identities = 64/276 (23%), Positives = 120/276 (43%), Gaps = 45/276 (16%)

Query: 1191 PIVSIPKAGRKPKIQESEETVEPK------EDMPLPEERKEEEE------------MQAE 1232
            P ++I    +KPK++  +  V+ K      E+  + +E+ E EE            M+ E
Sbjct: 428  PPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEE 487

Query: 1233 AEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQE 1292
             +EA E +EE+  + E   A+      +   E KE E E+EEE+ +        EEE++E
Sbjct: 488  KKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQ--------EEEEEE 539

Query: 1293 LEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFL 1352
             E  + ++ E+  +E   + + +  ++++G  E+      E +    + KEE  V+E   
Sbjct: 540  DEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA------EAEGEEAEAKEEKKVEE--- 590

Query: 1353 DANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEE 1412
                    E++  KEE   D++ E+P    S V +    S  + +  S   +  +E K +
Sbjct: 591  ------KSEEVATKEELVADAKVEKPEKAKSPVPK----SPVEEKGKSPVPKSPVEEKGK 640

Query: 1413 EEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEE 1448
              +P S ++ +    V     EE  +   +    EE
Sbjct: 641  SPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 676



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 112/509 (22%), Positives = 188/509 (36%), Gaps = 131/509 (25%)

Query: 777  TPVIVSNSVVSEEEEEEAEEGENEEPQCQEREL--EISVGKSVSHENKEQDSYSVESEKK 834
            T +    +V  +EE++EA E + EEP+ +E E+  + S  K+ + E KE++    E E +
Sbjct: 474  TAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQ 533

Query: 835  PEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSA 894
             E                                G K+ + +E   +K+     EE    
Sbjct: 534  EE--------------------------EEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQE 567

Query: 895  PQEQYGEC-GEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKK 953
              E   E  GE++EA +E+  E + + VA++E+   D K + P++         +  + K
Sbjct: 568  EGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKA--------KSPVPK 619

Query: 954  SPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRK 1013
            SP   K     G   +P+                S  EE+ +SP   SP        K K
Sbjct: 620  SPVEEK-----GKSPVPK----------------SPVEEKGKSPVPKSP-----VEEKGK 653

Query: 1014 KPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEE 1073
             P        + +   + S V E     + V   P E++ S+  + + E      ++EEE
Sbjct: 654  SPVPKSPVEEKGKSPVSKSPVEE--KAKSPVPKSPVEEAKSKAEVGKGE------QKEEE 705

Query: 1074 EDENELFPREYFRRLSSQDVLRCQSSSK---RKSKDEEEDEESDDADDTPILKPVSLLRK 1130
            E E +  P+E       + V + +   K    K K E   +E   A+   I K V +  +
Sbjct: 706  EKEVKEAPKE-------EKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLE 758

Query: 1131 RDVK--NSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACV 1188
            ++ K    PL+ +     K+K G   G   +        G   G K SR           
Sbjct: 759  KETKEEGKPLQQEKE---KEKAGGEGGSEEE--------GSDKGAKGSR----------- 796

Query: 1189 IEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEG-EEEDAASS 1247
                                     KED+ +  E + +EE++ E +E   G EEE    +
Sbjct: 797  -------------------------KEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVT 831

Query: 1248 EVPAASPADSSNSPETETKEPEVEEEEEK 1276
                 SPAD     +   ++  V +  EK
Sbjct: 832  NGLDLSPADEKKGGDKSEEKVVVTKTVEK 860



 Score = 35.8 bits (81), Expect = 0.43
 Identities = 58/275 (21%), Positives = 104/275 (37%), Gaps = 23/275 (8%)

Query: 770  DPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSV 829
            +PE          + V +   E + EEGE EE + QE E E   G + S + +E  S   
Sbjct: 498  EPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEG-AKSDQAEEGGSEKE 556

Query: 830  ESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLE 889
             S +K E       T         +   A ++  ++     +   T+E     D+K+   
Sbjct: 557  GSSEKEEGEQEEGETEAEA-----EGEEAEAKEEKKVEEKSEEVATKEEL-VADAKVEKP 610

Query: 890  ETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRG 949
            E + +P  +     +      +   E + +    +    + GK  +PK   S   E  + 
Sbjct: 611  EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK---SPVEEKGKS 667

Query: 950  QLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPT 1009
             + KSP   K +      + P   ++    V +G  +  EE+E  E+P+        K  
Sbjct: 668  PVSKSPVEEKAK--SPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEE------KVE 719

Query: 1010 LKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEV 1044
             K +KP     + V ++K   S V  E ++E   +
Sbjct: 720  KKEEKP-----KDVPEKKKAESPVKEEAVAEVVTI 749



 Score = 32.0 bits (71), Expect = 6.3
 Identities = 51/233 (21%), Positives = 86/233 (36%), Gaps = 36/233 (15%)

Query: 1330 KELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQM 1389
            K +EE      V++E    E  L A  ++    +K++++   + +EE+P           
Sbjct: 451  KFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPE---------- 500

Query: 1390 AGSEDDHEEDSHTKEELIELKE-----EEEIPHSELDLETVQAVQSLTQEESSEHEGAYQ 1444
            A  E+   + S  K    E+KE     EEE    E + E   A     +E  SE EG+ +
Sbjct: 501  AEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSE 560

Query: 1445 ----DCEETLAACQTLQSYTQADEDPQM-----------SMVEDCHASEHNSPISSVQSH 1489
                + EE     +      +A E+ ++            +V D    +     S V   
Sbjct: 561  KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKS 620

Query: 1490 PSQSVRSVSSPNVPALESGYTQI--SP--EQGSLSAPS--MQNMETSPMMDVP 1536
            P +       P  P  E G + +  SP  E+G    P   ++    SP+   P
Sbjct: 621  PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSP 673


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 [Homo
            sapiens]
          Length = 540

 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 105/455 (23%), Positives = 185/455 (40%), Gaps = 41/455 (9%)

Query: 989  EEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEP 1048
            EE++E    +   P    +    +K P       V++ +        E   E  E  DE 
Sbjct: 110  EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEE---EEGQEEEEEEDEG 166

Query: 1049 FEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEE 1108
             +   +E      E + E +E E+EE E E          +  +    +   K + K EE
Sbjct: 167  AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAE--------AEGEEAEAKEEKKVEEKSEE 218

Query: 1109 EDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPG 1168
               + +   D  + KP     K  V  SP+E    +P+ K     KGKS  P    +  G
Sbjct: 219  VATKEELVADAKVEKPEKA--KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 276

Query: 1169 RKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEE 1228
            + P  K      PV  +         + +  + P  +   E  + K ++   E+++EEE+
Sbjct: 277  KSPVPK-----SPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK 331

Query: 1229 MQAEAEEAEEGEEEDAASSEVPAASPADSSNSPE------TETKEPEVE-EEEEKPRVSE 1281
               EA + E+ E+++    +VP    A+S    E      T TK  +V  E+E K     
Sbjct: 332  EVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKP 391

Query: 1282 EQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTRE-- 1339
             Q++ E+E+   E    EE  D  A+ ++ +D   + E +G       KE  EQ T+E  
Sbjct: 392  LQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEG-------KEEVEQETKEKG 444

Query: 1340 -DVKEEPGVQESFLD---ANMQKSREKIKDK---EETELDSEEEQPSHDTSVVSEQMAGS 1392
               +EE GV  + LD   A+ +K  +K ++K    +T      E     T  +++ +  +
Sbjct: 445  SGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVT 504

Query: 1393 EDDHEEDSHTKEELIELKEEEEIPHSELDLETVQA 1427
            +   E +   +E+L+  K+ E++    +  E  Q+
Sbjct: 505  QKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQS 539



 Score = 81.3 bits (199), Expect = 9e-15
 Identities = 115/509 (22%), Positives = 195/509 (38%), Gaps = 88/509 (17%)

Query: 984  FSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTE 1043
            F E   EE + E  +S     LT  T +        ++   + K        E ++    
Sbjct: 76   FVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKS 135

Query: 1044 VLDEPFEDSDSERPMPRLEPTFEIDEEEEE--------------EDENELFPREYFRRLS 1089
             +     +   E      E   E +EEE+E              E  +E    E     +
Sbjct: 136  PVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGET 195

Query: 1090 SQDVLRCQSSSKRKSKDEEEDEE----SDDADDTPILKPVSLLRKRDVKNSPLEPDTSTP 1145
              +    ++ +K + K EE+ EE     +   D  + KP     K  V  SP+E    +P
Sbjct: 196  EAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEK--AKSPVPKSPVEEKGKSP 253

Query: 1146 LKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQ 1205
            + K     KGKS  P    +  G+ P                   P   + + G+ P   
Sbjct: 254  VPKSPVEEKGKSPVPKSPVEEKGKSP------------------VPKSPVEEKGKSP--- 292

Query: 1206 ESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETET 1265
             S+  VE K   P+P+   EE + +AE  + E+ EEE+    E P               
Sbjct: 293  VSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAP--------------- 337

Query: 1266 KEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLE 1325
            KE +VE++EEKP+   E++++E             +E+A AE               HLE
Sbjct: 338  KEEKVEKKEEKPKDVPEKKKAES----------PVKEEAVAEVV-----TITKSVKVHLE 382

Query: 1326 STKKKE---LEEQPTREDVKEEPGVQESFLDANMQKSRE-------KIKDKEETELDSEE 1375
               K+E   L+++  +E    E G +E   D   + SR+       +++ KEE E +++E
Sbjct: 383  KETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKE 442

Query: 1376 EQP--SHDTSVVSEQMAGSEDDHEEDSHTKEE-LIELKEEEEIPHSELDLETVQAVQSLT 1432
            +      +  VV+  +  S  D ++     EE ++  K  E+I     D  T    +S+T
Sbjct: 443  KGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVT 502

Query: 1433 -QEESSEHEGAYQDCEETLAACQTLQSYT 1460
              ++  EHE  +   EE L + + ++  T
Sbjct: 503  VTQKVEEHEETF---EEKLVSTKKVEKVT 528



 Score = 68.2 bits (165), Expect = 8e-11
 Identities = 64/276 (23%), Positives = 120/276 (43%), Gaps = 45/276 (16%)

Query: 1191 PIVSIPKAGRKPKIQESEETVEPK------EDMPLPEERKEEEE------------MQAE 1232
            P ++I    +KPK++  +  V+ K      E+  + +E+ E EE            M+ E
Sbjct: 52   PPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEE 111

Query: 1233 AEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQE 1292
             +EA E +EE+  + E   A+      +   E KE E E+EEE+ +        EEE++E
Sbjct: 112  KKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQ--------EEEEEE 163

Query: 1293 LEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFL 1352
             E  + ++ E+  +E   + + +  ++++G  E+      E +    + KEE  V+E   
Sbjct: 164  DEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA------EAEGEEAEAKEEKKVEE--- 214

Query: 1353 DANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEE 1412
                    E++  KEE   D++ E+P    S V +    S  + +  S   +  +E K +
Sbjct: 215  ------KSEEVATKEELVADAKVEKPEKAKSPVPK----SPVEEKGKSPVPKSPVEEKGK 264

Query: 1413 EEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEE 1448
              +P S ++ +    V     EE  +   +    EE
Sbjct: 265  SPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 300



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 112/509 (22%), Positives = 188/509 (36%), Gaps = 131/509 (25%)

Query: 777  TPVIVSNSVVSEEEEEEAEEGENEEPQCQEREL--EISVGKSVSHENKEQDSYSVESEKK 834
            T +    +V  +EE++EA E + EEP+ +E E+  + S  K+ + E KE++    E E +
Sbjct: 98   TAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQ 157

Query: 835  PEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSA 894
             E                                G K+ + +E   +K+     EE    
Sbjct: 158  EE--------------------------EEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQE 191

Query: 895  PQEQYGEC-GEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKK 953
              E   E  GE++EA +E+  E + + VA++E+   D K + P++         +  + K
Sbjct: 192  EGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKA--------KSPVPK 243

Query: 954  SPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRK 1013
            SP   K     G   +P+                S  EE+ +SP   SP        K K
Sbjct: 244  SPVEEK-----GKSPVPK----------------SPVEEKGKSPVPKSP-----VEEKGK 277

Query: 1014 KPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEE 1073
             P        + +   + S V E     + V   P E++ S+  + + E      ++EEE
Sbjct: 278  SPVPKSPVEEKGKSPVSKSPVEE--KAKSPVPKSPVEEAKSKAEVGKGE------QKEEE 329

Query: 1074 EDENELFPREYFRRLSSQDVLRCQSSSK---RKSKDEEEDEESDDADDTPILKPVSLLRK 1130
            E E +  P+E       + V + +   K    K K E   +E   A+   I K V +  +
Sbjct: 330  EKEVKEAPKE-------EKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLE 382

Query: 1131 RDVK--NSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACV 1188
            ++ K    PL+ +     K+K G   G   +        G   G K SR           
Sbjct: 383  KETKEEGKPLQQEKE---KEKAGGEGGSEEE--------GSDKGAKGSR----------- 420

Query: 1189 IEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEG-EEEDAASS 1247
                                     KED+ +  E + +EE++ E +E   G EEE    +
Sbjct: 421  -------------------------KEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVT 455

Query: 1248 EVPAASPADSSNSPETETKEPEVEEEEEK 1276
                 SPAD     +   ++  V +  EK
Sbjct: 456  NGLDLSPADEKKGGDKSEEKVVVTKTVEK 484



 Score = 35.8 bits (81), Expect = 0.43
 Identities = 58/275 (21%), Positives = 104/275 (37%), Gaps = 23/275 (8%)

Query: 770  DPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSV 829
            +PE          + V +   E + EEGE EE + QE E E   G + S + +E  S   
Sbjct: 122  EPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEG-AKSDQAEEGGSEKE 180

Query: 830  ESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLE 889
             S +K E       T         +   A ++  ++     +   T+E     D+K+   
Sbjct: 181  GSSEKEEGEQEEGETEAEA-----EGEEAEAKEEKKVEEKSEEVATKEEL-VADAKVEKP 234

Query: 890  ETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRG 949
            E + +P  +     +      +   E + +    +    + GK  +PK   S   E  + 
Sbjct: 235  EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK---SPVEEKGKS 291

Query: 950  QLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPT 1009
             + KSP   K +      + P   ++    V +G  +  EE+E  E+P+        K  
Sbjct: 292  PVSKSPVEEKAK--SPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEE------KVE 343

Query: 1010 LKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEV 1044
             K +KP     + V ++K   S V  E ++E   +
Sbjct: 344  KKEEKP-----KDVPEKKKAESPVKEEAVAEVVTI 373



 Score = 32.0 bits (71), Expect = 6.3
 Identities = 51/233 (21%), Positives = 86/233 (36%), Gaps = 36/233 (15%)

Query: 1330 KELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQM 1389
            K +EE      V++E    E  L A  ++    +K++++   + +EE+P           
Sbjct: 75   KFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPE---------- 124

Query: 1390 AGSEDDHEEDSHTKEELIELKE-----EEEIPHSELDLETVQAVQSLTQEESSEHEGAYQ 1444
            A  E+   + S  K    E+KE     EEE    E + E   A     +E  SE EG+ +
Sbjct: 125  AEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSE 184

Query: 1445 ----DCEETLAACQTLQSYTQADEDPQM-----------SMVEDCHASEHNSPISSVQSH 1489
                + EE     +      +A E+ ++            +V D    +     S V   
Sbjct: 185  KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKS 244

Query: 1490 PSQSVRSVSSPNVPALESGYTQI--SP--EQGSLSAPS--MQNMETSPMMDVP 1536
            P +       P  P  E G + +  SP  E+G    P   ++    SP+   P
Sbjct: 245  PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSP 297


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 85.5 bits (210), Expect = 5e-16
 Identities = 157/734 (21%), Positives = 286/734 (38%), Gaps = 112/734 (15%)

Query: 791  EEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQV 850
            +E+ E+    E + Q +E E +  +    E +   ++  ++E+K E      S R   + 
Sbjct: 733  QEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLRE 792

Query: 851  LPHDSLPANSQPSRRGRW-----GRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEK 905
                 L A  +  R  R+      ++ R+ Q R  +K+ + L EE     +E+  +  E+
Sbjct: 793  QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEE 852

Query: 906  SEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEP-WRGQLKKSPEALKCRLTE 964
             +  QE       Q    +++     + +  +RR +   +P  + QL+K  + L+    E
Sbjct: 853  EDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ----E 908

Query: 965  GSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVR 1024
              E L R   E  R       E   +  E E  +     +L +   +R+K    RRR+ R
Sbjct: 909  EEEELQREEREKRRR-----QEQERQYREEEQLQQEEEQLLRE---EREK----RRRQER 956

Query: 1025 KRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREY 1084
            +R++     + +   E   + +EP +    ER     E      EEE +++E +L   E 
Sbjct: 957  ERQYRKDKKLQQ--KEEQLLGEEPEKRRRQEREKKYRE------EEELQQEEEQLLREER 1008

Query: 1085 FRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLR----KRDVKNSPLEP 1140
             +R       R +   + + KDE + EE              LLR    KR ++    + 
Sbjct: 1009 EKRR------RQEWERQYRKKDELQQEEEQ------------LLREEREKRRLQERERQY 1050

Query: 1141 DTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGR 1200
                 L++++    G+ R+    ++R   +  ++   E+     Q    EP     K  R
Sbjct: 1051 REEEELQQEEEQLLGEERET---RRRQELERQYRKEEELQQEEEQLLREEP----EKRRR 1103

Query: 1201 KPKIQE--SEETVEPKEDMPLPEER------------KEEEEMQAEAEEAEEGEEEDAAS 1246
            + + ++   EE ++ +E+  L EER            +EEEE+Q E E+    E E    
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRR 1163

Query: 1247 SEVPAASPADSSNSPETET------------KEPEVEEEEEKPRVSEEQRQSEEEQQ-EL 1293
             E+      +     E E             +E +  EEEE  R   +QR  +E+Q+ +L
Sbjct: 1164 QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDL 1223

Query: 1294 E---EPEP--------------EEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQP 1336
            +   EPE               E E+    E +Q  D  +  +    L   ++++ E++ 
Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER 1283

Query: 1337 TREDVKEEPGVQESFLDANMQK--SREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSE- 1393
             R   ++    +E  L+   QK   R   K +EE +L  EE +          +    E 
Sbjct: 1284 RRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQ 1343

Query: 1394 --DDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETLA 1451
               + EE    ++E      EEE+ H E   + ++  Q L ++   E E  +   EE   
Sbjct: 1344 LLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQ---ERERKFLK-EEQQL 1399

Query: 1452 ACQTLQSYTQADED 1465
             CQ  +   + D D
Sbjct: 1400 RCQEREQQLRQDRD 1413



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 130/700 (18%), Positives = 263/700 (37%), Gaps = 68/700 (9%)

Query: 790  EEEEAEEGENEEPQC-----QERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSST 844
            E++E  E + E  +      QE   E  + +    E +EQ     + E++ E        
Sbjct: 323  EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382

Query: 845  RLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGE 904
               +Q L  +      Q  RR +  R+ ++ +     +  + L  E      EQ  E   
Sbjct: 383  LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER 442

Query: 905  KSEATQEQYTESEEQLVASEE---QPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCR 961
            + +  + +  E  + L   EE      +  K  L + +  E  E W   LK   E  + +
Sbjct: 443  REQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW---LKLEEEERREQ 499

Query: 962  LTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRR 1021
                 ++L R   E     L+      +EEEE    R  S   L +   +R++  L R  
Sbjct: 500  QERREQQLRREQEERREQRLK-----RQEEEERLQQRLRSEQQLRREQEERREQLLKREE 554

Query: 1022 RVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFP 1081
              R  +        + +    E   +     + ER   RL       + E+EE   +   
Sbjct: 555  EKRLEQERRE----QRLKREQEERRDQLLKREEERRQQRL-------KREQEERLEQRLK 603

Query: 1082 REYFRRLSSQDVLRCQSSSKRKSKDEE------EDEESDDADDTPILKPVSLLRKRDVKN 1135
            RE   RL  ++  R +   KR+  +EE      + EE ++     + +     R++ +K 
Sbjct: 604  REEVERLEQEE--RREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR 661

Query: 1136 SPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIE-PIVS 1194
               E      LK++    + +       +++   +   ++ +    + ++A   +  + S
Sbjct: 662  EEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS 721

Query: 1195 IPK--AGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAE------EAEEGEEEDAAS 1246
             P+   G++ + ++ E+    + ++   EE +   + Q E +      + +  E+ +   
Sbjct: 722  RPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGR 781

Query: 1247 SEVPAASPADSSNSPETETKEPE------VEEEEEKPRVSEEQRQSEEEQQELEEPEPEE 1300
              + A  P       +   +E +      + EEEEK +   ++R+ E+E Q LEE E  +
Sbjct: 782  QRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQ 841

Query: 1301 EEDAAAETAQNDDHDADDEDDGHLESTKKK-------ELEEQPTREDVKEEPGVQESFLD 1353
              + A +  + +D   +D++    +  ++        E E +  R  +  +P +QE    
Sbjct: 842  RRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL-- 899

Query: 1354 ANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEE 1413
                +  +++  +EE EL  EE +         +     +   EE+   +EE  + + +E
Sbjct: 900  ----RKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955

Query: 1414 EIPHSELDLETVQAVQSLTQEE-----SSEHEGAYQDCEE 1448
                   D +  Q  + L  EE       E E  Y++ EE
Sbjct: 956  RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEE 995



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 139/707 (19%), Positives = 275/707 (38%), Gaps = 101/707 (14%)

Query: 789  EEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRL-- 846
            EEEE   +   +  + +++  ++        EN  +D+      ++ E    +  ++L  
Sbjct: 1201 EEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRD 1260

Query: 847  --SKQVLPH--DSLPANSQPSRRGRWGRKNR----------------KTQERFGDKDSKL 886
              S+Q L H         +   R RW +++R                K ++R   ++ +L
Sbjct: 1261 RQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL 1320

Query: 887  LLEETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPK----RRLSE 942
            L EE     + Q  E   K    ++   E EEQ +  +E+  +  + +L      R+  E
Sbjct: 1321 LREEREEKRRRQ--ETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLE 1378

Query: 943  GVEPWRGQLK-----KSPEALKCRLTEGSERLPR--RYSEGDRAVLRGFSESSEEEEEPE 995
              +  R Q +     K  + L+C+  E   R  R  ++ E ++ + R   +    EEE +
Sbjct: 1379 EEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQ 1438

Query: 996  SPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVL------DEPF 1049
              R            +R++ FL   +++R+ +H       + + E  E        D  F
Sbjct: 1439 VRRQ-----------ERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKF 1487

Query: 1050 EDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEE 1109
             + + +      +  F   E   +E E +    E  ++L  Q   R     +++ + +E 
Sbjct: 1488 LEEEQQLRRQERDRKFREQELRSQEPERKFLEEE--QQLHRQQRQRKFLQEEQQLRRQER 1545

Query: 1110 DEESDDADDTPILKPVSLLRKRDVKN-SPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPG 1168
             ++     D    +   L ++R+ +  S  E D    L+++K   + + RK +  +++  
Sbjct: 1546 GQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR 1605

Query: 1169 RKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKE--- 1225
            R+ G +  R+                     R  K +E E+ ++ +E+  L  + ++   
Sbjct: 1606 RQEGQQQLRQ--------------------ERDRKFREDEQLLQEREEQQLHRQERDRKF 1645

Query: 1226 -EEEMQAEAEEAEEG--EEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEE 1282
             EEE Q   +E E+    + D    E               + ++ +  EEE++ R  E 
Sbjct: 1646 LEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQER 1705

Query: 1283 QRQSEEEQQELEEPEPE----EEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTR 1338
            +R+  +E+Q+L   E E    EEE    ET Q      +       E   + E EEQ  R
Sbjct: 1706 ERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLR 1765

Query: 1339 ED-----VKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSE 1393
                    +EE  +++   +  ++      K +EE +L  E E+         +Q+   +
Sbjct: 1766 RQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREE---------QQLRPQQ 1816

Query: 1394 DDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHE 1440
             D +     +EE ++L+E+E+    E D +     Q  TQE+S   E
Sbjct: 1817 RDGK--YRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE 1861



 Score = 81.3 bits (199), Expect = 9e-15
 Identities = 160/780 (20%), Positives = 298/780 (38%), Gaps = 76/780 (9%)

Query: 748  RREKLI--QDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQ 805
            RRE+ +  Q+   +LQ  LR      + LR         ++  EEE+  E+   E+   +
Sbjct: 514  RREQRLKRQEEEERLQQRLR----SEQQLRREQEERREQLLKREEEKRLEQERREQRLKR 569

Query: 806  ERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRR 865
            E+E           E ++Q     + E+  + +      RL ++      L        R
Sbjct: 570  EQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEER 629

Query: 866  GRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEE 925
             +   K+ + +ER   +  +   E      + +  E   +    +E   E  EQ +A EE
Sbjct: 630  RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEE 689

Query: 926  QPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLP--RRYSEGDRAVLRG 983
            Q       +  + R+   +  W+ QL+   +A + ++     +    RR  E +    R 
Sbjct: 690  Q-------EQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742

Query: 984  FSESSEEEEE--------PESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVT 1035
             SE   +EEE         E  R  +     +   +R +  L  R  +R+++        
Sbjct: 743  ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE 802

Query: 1036 ETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLR 1095
                E   +   P E+   +R   R E   E+   EEEE   +L  RE  ++L  ++   
Sbjct: 803  RQQREQRFL---PEEEEKEQRRRQRREREKELQFLEEEE---QLQRRERAQQLQEEEDGL 856

Query: 1096 CQSSSKRKSKDEEED--------EESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLK 1147
             +   +R+S+++  D        EE      T   KP   L+++  K   L  +    L+
Sbjct: 857  QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA--LQEQLRKEQQLLQEEEEELQ 914

Query: 1148 KKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPK-IQE 1206
            +++   + +  +   +++        +L +E   +  +           +  RK K +Q+
Sbjct: 915  REEREKRRRQEQERQYREEE------QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQ 968

Query: 1207 SEETV---EPKEDMPLPEERK--EEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSP 1261
             EE +   EP++      E+K  EEEE+Q E E+    E E     E             
Sbjct: 969  KEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQ 1028

Query: 1262 ETETKEPEVEEEEEKPRVSEEQRQSEEE---QQELEEPEPEEEEDAAAETAQND---DHD 1315
            E   +E  + EE EK R+ E +RQ  EE   QQE E+   EE E    +  +     + +
Sbjct: 1029 E---EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEE 1085

Query: 1316 ADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIK----------- 1364
               E++  L    +K   ++  R+  +EE   QE   +  +++ REK +           
Sbjct: 1086 LQQEEEQLLREEPEKRRRQERERQCREEEELQQEE--EQLLREEREKRRRQELERQYREE 1143

Query: 1365 ---DKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELD 1421
                +EE +L  EE +      +  +     E   EE+   +EE  + ++E E  + E +
Sbjct: 1144 EEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEE 1203

Query: 1422 LETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNS 1481
                Q  +   ++E    +  +Q   E   A +  + Y +  E+ Q   +ED    +  S
Sbjct: 1204 ELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQS 1263



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 140/707 (19%), Positives = 267/707 (37%), Gaps = 49/707 (6%)

Query: 792  EEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVL 851
            +  E  E EE + +E +L+   G    HE +E      E  ++ E++      R  KQ  
Sbjct: 176  QRQEWQEREERRAEEEQLQSCKG----HETEEFPDE--EQLRRRELLELRRKGREEKQQQ 229

Query: 852  PHDSLPANSQPSRRGRWGRKN-------RKTQERFGDKDSKLLLEETSSAPQEQYGECGE 904
              +      Q      W ++         K QE    +  +L  EE      E+     E
Sbjct: 230  RRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRE 289

Query: 905  KSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTE 964
            + E  Q+Q     EQ +  +++  ++ +    +RR  E  E    Q ++  + L+    E
Sbjct: 290  RQEEEQQQQRLRREQQLRRKQE--EERREQQEERR--EQQERREQQEERREQQLRREQEE 345

Query: 965  GSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVR 1024
              E+  RR  E +R   +   E  EE  E +  R      L +    R++  L R +++R
Sbjct: 346  RREQQLRREQEEERREQQLRREQEEERREQQLRREQQ---LRREQQLRREQQLRREQQLR 402

Query: 1025 K----RKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEE---DEN 1077
            +    R+        +   E     ++  E  + +    R E   + ++EE  +    E 
Sbjct: 403  REQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREE 462

Query: 1078 ELFPREYFRRLSSQDVLRCQSSSKRK---SKDEEEDEESDDADDTPILKPVSLLRKRDVK 1134
            E    E  RR   Q + R Q   +R+     +EEE  E  +  +  + +     R++ +K
Sbjct: 463  ETERHEQERR--KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLK 520

Query: 1135 NSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVS 1194
                E      L+ ++   + +  +     KR   K   +  RE      Q    + ++ 
Sbjct: 521  RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLK 580

Query: 1195 IPKAGRKPKIQ-ESEETVEPKEDMPLPE--ERKEEEEMQAEAEEAEEGEEEDAASSEVPA 1251
              +  R+ +++ E EE +E +      E  E++E  E + + EE EE   +    SE   
Sbjct: 581  REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640

Query: 1252 ASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEE---QQELEEPEPEEEEDAAAET 1308
                      + E +E  ++ EEE+ R+ +  ++  EE   +QEL E E E+  +     
Sbjct: 641  ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSR 700

Query: 1309 AQNDDHDADDEDDGHLES--TKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDK 1366
                    + E D       ++ ++ E Q  R++ +E+   +ES L    ++   + + +
Sbjct: 701  IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQE 760

Query: 1367 EETELDSEEEQPSHDTSVVSEQMAGSEDD---------HEEDSHTKEELIELKEEEEIPH 1417
            EE   D   +  + + S    Q   +              E+   +E+    +EEE+   
Sbjct: 761  EEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQR 820

Query: 1418 SELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADE 1464
                 E  + +Q L +EE  +     Q  +E     Q  Q   ++ E
Sbjct: 821  RRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQE 867



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 123/666 (18%), Positives = 261/666 (39%), Gaps = 54/666 (8%)

Query: 789  EEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSK 848
            ++  + E+    EP+  +R+LE   G+    + +EQ+    E E++ E    +      +
Sbjct: 111  QDRRQEEDQRRFEPR--DRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQR 168

Query: 849  --QVLPHDSLPANSQPSRRGRWGR----KNRKTQERFGDKDS---KLLLEETSSAPQEQY 899
              + L         +  RR    +    K  +T+E F D++    + LLE      +E+ 
Sbjct: 169  RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEE-FPDEEQLRRRELLELRRKGREEKQ 227

Query: 900  GECGEKSEATQEQYTESE----EQLVASEEQPSQDGKPDLPKRRLSEGVEPWRG------ 949
             +  E+ +   ++  E E    E ++  EE+  Q+ +P   +R L E  E  R       
Sbjct: 228  QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ-RQRELQEEEEQLRKLERQEL 286

Query: 950  QLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPT 1009
            + ++  E  + +     ++L R+  E  R       E  E  E+ E  R      L +  
Sbjct: 287  RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQ---LRREQ 343

Query: 1010 LKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDE 1069
             +R++  L R +   +R+        E   E     ++        R   +L    ++  
Sbjct: 344  EERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRR 403

Query: 1070 EEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEES----DDADDTPILKPV 1125
            E++   E +L   +  RR   Q + R Q   + + K E+E  E     +  +    LK  
Sbjct: 404  EQQLRREQQLRREQQLRR--EQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKRE 461

Query: 1126 SLLRKRDVKNSPLEPDTSTPLKKKKGWPK---GKSRKPIHWKKRPGRKPGFKLSREIMPV 1182
                + + +    +       ++++ W K    + R+    +++  R+   +   + +  
Sbjct: 462  EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKR 521

Query: 1183 STQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEE--GE 1240
              +   ++  +   +  R+ + +  E+ ++ +E+  L +ER+E+   + + E  ++    
Sbjct: 522  QEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKR 581

Query: 1241 EEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEE 1300
            EE+     +            + E  E   +EE  + R+  E+ + E  QQ L+  E EE
Sbjct: 582  EEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641

Query: 1301 EEDAAAETAQNDDHD---ADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQ 1357
                     Q +  +     +E++  LE   K+E EE+   +++ EE            +
Sbjct: 642  RRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE----------EQE 691

Query: 1358 KSREKIKD---KEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELK-EEE 1413
            ++RE+IK    K + +L+SE +           +  G     E++   +    EL+ +EE
Sbjct: 692  QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE 751

Query: 1414 EIPHSE 1419
            E  H +
Sbjct: 752  ERAHRQ 757



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 98/433 (22%), Positives = 170/433 (39%), Gaps = 47/433 (10%)

Query: 1050 EDSDSERPMPRLEPTFEIDEEEEEEDENE-LFPREYFRRLSSQDVLRCQSSSKRKSKDEE 1108
            E+    R   R E   E+ E EE+ ++ E L  R+  RR       R +   + + + EE
Sbjct: 131  EEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEE 190

Query: 1109 EDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPG 1168
            E  +S    +T        LR+R++            L+ ++   KG+  K    ++R  
Sbjct: 191  EQLQSCKGHETEEFPDEEQLRRREL------------LELRR---KGREEKQQQRRERQD 235

Query: 1169 RKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEE 1228
            R    +  +E     T     E  +   +  R+ ++QE EE +   E   L  ER+EEE+
Sbjct: 236  RVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQ 295

Query: 1229 MQ--AEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQS 1286
             Q     E+    ++E+    +             + E +E ++  E+E+ R  + +R+ 
Sbjct: 296  QQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQ 355

Query: 1287 EEEQQE----LEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKE----------L 1332
            EEE++E     E+ E   E+    E     +     E     E   ++E           
Sbjct: 356  EEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 415

Query: 1333 EEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETE----LDSEEEQPSHDTSVVSEQ 1388
            E+Q  RE        +E     + Q+ RE+   +E+ E    L  EEE   H+     +Q
Sbjct: 416  EQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQ 475

Query: 1389 MAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEE 1448
            +   +++   +   K E  E +E++E    +L  E         QEE  E     Q+ EE
Sbjct: 476  LKRDQEEERRERWLKLEEEERREQQERREQQLRRE---------QEERREQRLKRQEEEE 526

Query: 1449 TLAACQTLQSYTQ 1461
             L   Q L+S  Q
Sbjct: 527  RLQ--QRLRSEQQ 537



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 126/660 (19%), Positives = 262/660 (39%), Gaps = 85/660 (12%)

Query: 790  EEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQ 849
            EEE+ E  E +E + ++R+ +    K +  E +E+     E+++K          R  +Q
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEE--KQLLREEREEKRRRQETDRK---------FREEEQ 1343

Query: 850  VLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEAT 909
            +L         QP RR    RK R+ + R  ++  K L EE     QE+  E     E  
Sbjct: 1344 LLQE----REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQER--ERKFLKEEQ 1397

Query: 910  QEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERL 969
            Q +  E E+QL    ++  ++ +  L ++           Q+++     K    E   R 
Sbjct: 1398 QLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQ 1457

Query: 970  PRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHH 1029
             R          R   +  +E EE +  R            +R + FL   +++R+++  
Sbjct: 1458 ERHRK------FREEEQLLQEREEQQLHRQ-----------ERDRKFLEEEQQLRRQERD 1500

Query: 1030 NSSVVTETISETTE--VLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRR 1087
                  E  S+  E   L+E  +    +R    L+   ++  +E  +   +    +  R+
Sbjct: 1501 RKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQ----DRDRK 1556

Query: 1088 LSSQDVLRCQSSSKRKSKDE-------EEDEESDDADDTPILKPVSLLRKRDVKNSPLEP 1140
               ++ LR +   ++ S+ E       EE +      +   ++    LR+++ +   L  
Sbjct: 1557 FREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQ-LRQ 1615

Query: 1141 DTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGR 1200
            +     ++ +   + +  + +H ++R          R+ +    Q    E    + +  R
Sbjct: 1616 ERDRKFREDEQLLQEREEQQLHRQER---------DRKFLEEEPQLRRQEREQQL-RHDR 1665

Query: 1201 KPKIQESEETVEPKEDMPLPEERKE----EEEMQAEAEEAEEG---EEEDAASSEVPAAS 1253
              K +E E+ ++  E+  L  + ++    EEE Q   +E E     EE+     E+    
Sbjct: 1666 DRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKF 1725

Query: 1254 PADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDD 1313
              +     ETE ++   +E   K  + EEQ + E E+Q+L      +E D      +   
Sbjct: 1726 REEEQLRQETEQEQLRRQERYRKI-LEEEQLRPEREEQQLRR----QERDRKFREEEQLR 1780

Query: 1314 HDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDA---------NMQKSREKIK 1364
             + +++     ES +K   EEQ  +E  +EE  ++    D           +++  ++++
Sbjct: 1781 QEREEQQLRSQESDRKFREEEQLRQE--REEQQLRPQQRDGKYRWEEEQLQLEEQEQRLR 1838

Query: 1365 DKEETELDSEEEQPSHDTSVVSEQMAGSEDD----HEEDSHTKEELIELKEEEEIPHSEL 1420
             + + +  +EE+  + + S   EQ    E++     E +   +EE I  +++EE  H ++
Sbjct: 1839 QERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQV 1898



 Score = 65.1 bits (157), Expect = 7e-10
 Identities = 61/294 (20%), Positives = 127/294 (43%), Gaps = 19/294 (6%)

Query: 1203 KIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPE 1262
            ++ E EE  E +E +   + ++ +EE+  + +E +E EE  A   ++ +    ++   P+
Sbjct: 147  ELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPD 206

Query: 1263 TET-KEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDD 1321
             E  +  E+ E   K R  E+Q+Q  E Q  + + E E+E        + ++    +E+ 
Sbjct: 207  EEQLRRRELLELRRKGR-EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265

Query: 1322 GHLESTKKKE-----LEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEE 1376
                  +++E     LE Q  R + +EE   Q+        + +++ + +E+ E   E++
Sbjct: 266  QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325

Query: 1377 QPSHDTSVVSEQMAGSEDD--------HEEDSHTKEELIELKEEEEIPHSELDLE-TVQA 1427
            +         EQ    E +         E++   +E+ +  ++EEE    +L  E  ++ 
Sbjct: 326  ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR 385

Query: 1428 VQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQM--SMVEDCHASEH 1479
             Q L +E+    E   +  E+ L   Q L+   Q   + Q+     E+ H  +H
Sbjct: 386  EQQLRREQQLRREQQLRR-EQQLRREQQLRREQQLRREQQLRREQEEERHEQKH 438



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 56/245 (22%), Positives = 106/245 (43%), Gaps = 16/245 (6%)

Query: 1205 QESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETE 1264
            +E     + KE + L + R+EE++ + E  + +  EE      +       + +   E  
Sbjct: 97   EEKRARCDGKESL-LQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155

Query: 1265 TKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDH-DADDEDDGH 1323
             K+  +E+ + + R  E  RQ  +E QE EE   EEE+  + +  + ++  D +      
Sbjct: 156  EKQERLEQRDRQRRDEELWRQ-RQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214

Query: 1324 LESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTS 1383
            L   ++K  EE+  +   +++   QE   +    + RE +  KEE +L  EE Q   +  
Sbjct: 215  LLELRRKGREEKQQQRRERQDRVFQEE--EEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272

Query: 1384 VVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAY 1443
               EQ+   E         ++EL   ++EEE     L  E  Q ++   +EE  E +   
Sbjct: 273  EEEEQLRKLE---------RQELRRERQEEEQQQQRLRRE--QQLRRKQEEERREQQEER 321

Query: 1444 QDCEE 1448
            ++ +E
Sbjct: 322  REQQE 326



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 106/587 (18%), Positives = 227/587 (38%), Gaps = 83/587 (14%)

Query: 789  EEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKK-PEVMAPVSSTRLS 847
            +E E     E ++ +CQERE ++   +      +EQ     E ++K  E    V      
Sbjct: 1386 QERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445

Query: 848  KQVLPHDSLPANSQPSRRGRWGRKNRKTQERFG------DKDSKLLLEETSSAPQEQ--- 898
            ++ L  +      +  R  ++  + +  QER        ++D K L EE     QE+   
Sbjct: 1446 RKFLEEEQ---QLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRK 1502

Query: 899  YGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEAL 958
            + E   +S+  + ++ E E+QL   + Q  +  + +   RR   G +  + + +K  E  
Sbjct: 1503 FREQELRSQEPERKFLEEEQQLHRQQRQ-RKFLQEEQQLRRQERGQQRRQDRDRKFREEE 1561

Query: 959  KCRLTEGSERLPR-----RYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRK 1013
            + R     ++L R     ++   ++ V R   E    E+E +  R      L +   +R 
Sbjct: 1562 QLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQ---ERD 1618

Query: 1014 KPFLHRRRRVRKRKH---HNSSVVTETISETTEVLDEPFEDS---DSERPMPRLEPTFEI 1067
            + F    + +++R+    H      + + E  ++  +  E     D +R     E   + 
Sbjct: 1619 RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678

Query: 1068 DEEEE----------EEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDAD 1117
             EE++           E+E +L  +E  R+   ++    +   +RK ++EE+  +  + +
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738

Query: 1118 DTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSR 1177
                      LR+++     LE +   P ++++   + +  +    +++       +  R
Sbjct: 1739 Q---------LRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQ------LRQER 1783

Query: 1178 EIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPL-PEERK-----EEEEMQA 1231
            E   + +Q                 K +E E+  + +E+  L P++R      EEE++Q 
Sbjct: 1784 EEQQLRSQES-------------DRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQL 1830

Query: 1232 EAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQ 1291
            E +E    +E D                  +  T+E    EE+E  +  E++R+ E E++
Sbjct: 1831 EEQEQRLRQERDRQYRA-----------EEQFATQEKSRREEQELWQEEEQKRRQERERK 1879

Query: 1292 ELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTR 1338
              EE    ++++        +    + +  G L      +    P R
Sbjct: 1880 LREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVPVR 1926


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
            sapiens]
          Length = 1220

 Score = 85.5 bits (210), Expect = 5e-16
 Identities = 129/612 (21%), Positives = 252/612 (41%), Gaps = 85/612 (13%)

Query: 796  EGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDS 855
            E   EE   ++++ +   GK  S ++ + +    +  K  +   P    ++       D 
Sbjct: 85   ENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKP----KVEMYSGSDDD 140

Query: 856  LPANSQPSR-RGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEATQEQYT 914
               N  P + +G+  + N+K      D+D+   ++E S       GE G++S+    ++ 
Sbjct: 141  DDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSS--GESGDESD----EFL 194

Query: 915  ESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRRYS 974
            +S +      ++ +Q  KP      +  G E      K    A K    E  ER  R+  
Sbjct: 195  QSRKG-----QKKNQKNKPG---PNIESGNEDDDASFKIKTVAQK--KAEKKER-ERKKR 243

Query: 975  EGDRAVLRGFSESSEEE--EEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSS 1032
            + ++A LR   E  E E  ++ +S +  S     + T+K K                  +
Sbjct: 244  DEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKV-----------------T 286

Query: 1033 VVTETISETTEVLDEPFE-DSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQ 1091
            V T  I  + E  + P   + D+E    + +   +  E+EE+E E +  P        S+
Sbjct: 287  VDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGP--------SK 338

Query: 1092 DVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKG 1151
              ++    +  K K+EEE ++ ++ +    L+ +   RK + +   LE +     K+K+ 
Sbjct: 339  ATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEER---LEQEKRERKKQKEK 395

Query: 1152 WPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAG------RKPKIQ 1205
              K + +K      +  R+   +    +  +  Q   +    S+PK        ++ KI 
Sbjct: 396  ERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIP 455

Query: 1206 ESEETVEPKEDMPL-------PEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSS 1258
            +  E+ E  E M L        +   E+EE     E  EE + EDA   +  A +  + +
Sbjct: 456  QQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEET 515

Query: 1259 NSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADD 1318
               E      EV+E  E+    EE+ + +EE +E EE   EE E   +E  + D+  +D+
Sbjct: 516  EKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEE---EEGESEGSEGDEEDEKVSDE 572

Query: 1319 EDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSR-EKIKDKEETELDSEEEQ 1377
            +D G       K L+++P++E         +S  D++  +++ E+  DK +  +  E+ +
Sbjct: 573  KDSG-------KTLDKKPSKE------MSSDSEYDSDDDRTKEERAYDKAKRRI--EKRR 617

Query: 1378 PSHDTSVVSEQM 1389
              H  +V +E++
Sbjct: 618  LEHSKNVNTEKL 629



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 133/627 (21%), Positives = 241/627 (38%), Gaps = 102/627 (16%)

Query: 858  ANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEATQEQYTESE 917
            A  Q  ++ +  +K  K ++ F + D   +L+E      E  G   ++     +    +E
Sbjct: 32   AKEQEPQKSKGKKKKEKKKQDFDEDD---ILKELEELSLEAQGIKADRETVAVKPTENNE 88

Query: 918  EQLVASEEQPS-QDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSE------RLP 970
            E+  + +++   Q GK        SE +E    + KK+ +  K  +  GS+      +LP
Sbjct: 89   EEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKP-KVEMYSGSDDDDDFNKLP 147

Query: 971  RRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHN 1030
            ++     +   + +  S E+E+  +  +  S    +  +      FL  R+  +K + + 
Sbjct: 148  KKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNK 207

Query: 1031 SSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSS 1090
                 E+ +E         +D  S +     +   E  E E ++ + E   +   R+L  
Sbjct: 208  PGPNIESGNE---------DDDASFKIKTVAQKKAEKKERERKKRDEE---KAKLRKLKE 255

Query: 1091 QDVLRCQSSSKRKSKD-----EEEDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTP 1145
            ++ L      + K K+     EEE  +S    DT ++ P S   K +   +  + +    
Sbjct: 256  KEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVI-PASE-EKAETPTAAEDDNEGDK 313

Query: 1146 LKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQ 1205
             KK K   KG+  +    KK+   K   K  +E               ++ K   + + Q
Sbjct: 314  KKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQE---------------ALAKLKEEEERQ 358

Query: 1206 ESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEED---------------------- 1243
            + EE    K    L  +RKEEE ++ E  E ++ +E++                      
Sbjct: 359  KREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARAR 418

Query: 1244 ---------AASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQR---------Q 1285
                     A   EVP+            + K  ++ ++ E   VSE            Q
Sbjct: 419  AEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQ 478

Query: 1286 SEEEQQELEEP-EPEEEEDAAAETAQNDDHDA--DDEDDGHLESTKKK-ELEEQPTREDV 1341
               E++E   P EPEEEED   E A  DD +A   DE+   +E  K   E++E P  E+ 
Sbjct: 479  GVPEKEETPPPVEPEEEEDT--EDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEE 536

Query: 1342 KEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSV-------VSEQMAGSED 1394
            +EE    E   D   ++  E+  + E +E D E+E+ S +           S++M+   +
Sbjct: 537  EEE----EEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSE 592

Query: 1395 DHEEDSHTKEELIELKEEEEIPHSELD 1421
               +D  TKEE    K +  I    L+
Sbjct: 593  YDSDDDRTKEERAYDKAKRRIEKRRLE 619



 Score = 78.2 bits (191), Expect = 8e-14
 Identities = 126/591 (21%), Positives = 235/591 (39%), Gaps = 90/591 (15%)

Query: 953  KSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKR 1012
            K  E  K +  +  E+  + + E D  +L+   E S E +  ++ R +   +  KPT   
Sbjct: 33   KEQEPQKSKGKKKKEKKKQDFDEDD--ILKELEELSLEAQGIKADRET---VAVKPTENN 87

Query: 1013 KKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEE 1072
            ++ F  + ++ + +K    S              E  ED DS +     +P  E+    +
Sbjct: 88   EEEFTSKDKKKKGQKGKKQSFDDND--------SEELEDKDS-KSKKTAKPKVEMYSGSD 138

Query: 1073 EEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEES-------------DDADDT 1119
            ++D+        F +L  +   + Q S+K+    EE+++ S             +  D++
Sbjct: 139  DDDD--------FNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDES 190

Query: 1120 PILKPVSLLRKRDVKNSPL------EPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGF 1173
                     +K++ KN P         D     K K    K   +K    KKR   K   
Sbjct: 191  DEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKL 250

Query: 1174 KLSREIMPVST---------------QACVIEPIVSIPKAGRKPKIQESEET-VEPKEDM 1217
            +  +E   + T               +   ++  V++   G  P  +E  ET    ++D 
Sbjct: 251  RKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVD-TGVIPASEEKAETPTAAEDDN 309

Query: 1218 PLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEE----- 1272
               +++K++++ + E EE E+ +++  + + V A   A +    E E ++ E EE     
Sbjct: 310  EGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRL 369

Query: 1273 EEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAE--TAQNDDHDADDEDDGHLESTKKK 1330
            EE + +  EE+R  +E+++  ++ E E +E    E         +A    +  L+  + +
Sbjct: 370  EELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQ 429

Query: 1331 ELE---------EQPTREDVK--------EEPGVQESF-LDANMQKSREKIKDKEETE-- 1370
             +E         ++P  ED K        E   V ES  L A ++   + + +KEET   
Sbjct: 430  GVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPP 489

Query: 1371 LDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQS 1430
            ++ EEE+ + D  +   +   S+++ E+    K   IE+KE  E    E + E       
Sbjct: 490  VEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVH-IEVKENPEEEEEEEEEEEEDEESE 548

Query: 1431 LTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNS 1481
              +EE  E EG+  D EE         S    D+ P   M  D   SE++S
Sbjct: 549  EEEEEEGESEGSEGD-EEDEKVSDEKDSGKTLDKKPSKEMSSD---SEYDS 595



 Score = 35.8 bits (81), Expect = 0.43
 Identities = 63/307 (20%), Positives = 113/307 (36%), Gaps = 59/307 (19%)

Query: 788  EEEEEEAEEGEN---------------EEPQCQERELEISVGKSVSHENKEQDSYSVESE 832
            EE+E+E ++G +               EE + Q+RE E  + +    E K ++   +E E
Sbjct: 326  EEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQE 385

Query: 833  KKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQER-------------- 878
            K+          +  +++     L   SQ   R R     +  Q +              
Sbjct: 386  KRERKKQKEKERK--ERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKR 443

Query: 879  --FGDKDSKLLLEETSSAPQEQYGECGEKSEATQEQYTESEE---QLVASEEQPSQD-GK 932
              + DK  K + ++  S    +  E     E  ++   E EE    +   EE+ ++D G 
Sbjct: 444  PIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGL 503

Query: 933  PDLPKRRLSEGVEPWRG-----QLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSES 987
             D       E  E   G     ++K++PE  +    E  E       E +     G SE 
Sbjct: 504  DDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEG-SEG 562

Query: 988  SEEEEEPESPRSSSPPILTKPT---------------LKRKKPFLHRRRRVRKRK-HHNS 1031
             EE+E+    + S   +  KP+                K ++ +   +RR+ KR+  H+ 
Sbjct: 563  DEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSK 622

Query: 1032 SVVTETI 1038
            +V TE +
Sbjct: 623  NVNTEKL 629



 Score = 32.0 bits (71), Expect = 6.3
 Identities = 20/48 (41%), Positives = 23/48 (47%), Gaps = 1/48 (2%)

Query: 786 VSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEK 833
           V E  EEE EE E EE   +  E E   G+S   E  E+D   V  EK
Sbjct: 527 VKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDE-KVSDEK 573


>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
          Length = 2454

 Score = 85.1 bits (209), Expect = 6e-16
 Identities = 137/658 (20%), Positives = 254/658 (38%), Gaps = 91/658 (13%)

Query: 806  ERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQ--PS 863
            E+ L+       S ++K+Q     E +KKP         ++ K    ++S    ++  P 
Sbjct: 928  EKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDF----KKKVIKMEQQYESSSDGTEKLPE 983

Query: 864  RRGRW----GRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEATQEQYTESEEQ 919
            R        G K  K     G+K SK + ++TS   +++  +  EKS       T   + 
Sbjct: 984  REEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKK-KDELSDYAEKS-------TGKGDS 1035

Query: 920  LVASEEQPSQDGKPDLPKRRLSE-GVEPWRGQLKKSPEALKCRLTE-GSERLPRRYSEGD 977
              +SE++ S++G     K+R    G    + Q   S +  K  + E G     +R    +
Sbjct: 1036 CDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIE 1095

Query: 978  RAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTET 1037
                R  S     +E      SS     ++   K+K+    +++ V  ++   +S+ T T
Sbjct: 1096 LRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTST 1155

Query: 1038 ISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQ 1097
              +  ++      D         +E   +    E   DE ++ P      LSS       
Sbjct: 1156 KRKQADITSSSSSD---------IEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQS 1206

Query: 1098 SSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVK-NSPLEPDTSTPLKKKKGWPKGK 1156
            S  +  SK      + DD D+ P  +    +   ++K N   + D S+  + ++G     
Sbjct: 1207 SGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEG----- 1261

Query: 1157 SRKPIHWKKRPGRK----PGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQE------ 1206
                   KKR G++    PG + ++  +   +         S  +  +KP+ +       
Sbjct: 1262 -------KKRTGKQNEENPGDEEAKNQVNSESD--------SDSEESKKPRYRHRLLRHK 1306

Query: 1207 ---------SEETVEPKEDMPLP--EERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPA 1255
                      E+  +PKE   +     RK   E   +++  E G  E+ + SE       
Sbjct: 1307 LTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRT 1366

Query: 1256 DSSNSPETETKEPEVEEEEEKPRV-------SEEQRQSEEEQQELEEPEPEEEEDAAAET 1308
             S+   E E  +   ++++++ R+       SE +  SEEE++E EE E EEEE+   E 
Sbjct: 1367 RSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEE 1426

Query: 1309 AQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEE 1368
             +NDD  +  +    +    K +     T+  +KEE   ++    A  ++ REK+++  E
Sbjct: 1427 DENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRI--AEREREREKLREVIE 1484

Query: 1369 TELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQ 1426
             E  S  + P     V+           +ED  TKE L+++     I      ++ VQ
Sbjct: 1485 IEDASPTKCPITTKLVL-----------DEDEETKEPLVQVHRNMVIKLKPHQVDGVQ 1531



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 68/364 (18%), Positives = 137/364 (37%), Gaps = 27/364 (7%)

Query: 1098 SSSKRKSKDEEEDEESDDADDTPILKPVSLLR--KRDVKNSPLEPDTSTPLKKKKGWPKG 1155
            S  KR+++ E  + +S+   +   +  +   R  K+ + N+  + D+S   K  K     
Sbjct: 766  SKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTK-DFDSSEDEKHSKKGMDN 824

Query: 1156 KSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKE 1215
            +  K +   +        +        S +  V +    +    R PK Q++  + +  +
Sbjct: 825  QGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVD 884

Query: 1216 DMPLPEERKEEEEMQAEAEEAEEGEE---------EDAASSEVPAASPADSSNSPETETK 1266
             +   E+     E++  AE  E+ +          +D  S         D S+    + K
Sbjct: 885  KLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDK 944

Query: 1267 EPEVEEEEEKPRVSEEQRQSEEEQQELE------EPEPEEEE----DAAAETAQNDDHDA 1316
            +   +  EEK + S+ +++  + +Q+ E      E  PE EE        +  +N   D 
Sbjct: 945  KQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDG 1004

Query: 1317 DDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKI--KDKEETELDSE 1374
            + +     + T KK+ E     E   +  G  +S   +  +KS+     ++K+  +L  +
Sbjct: 1005 EKKSKKIRDKTSKKKDELSDYAE---KSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGK 1061

Query: 1375 EEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQE 1434
              +   D S    +    ++D    S  + + IEL+E   +       E      S   E
Sbjct: 1062 SSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAE 1121

Query: 1435 ESSE 1438
            ESSE
Sbjct: 1122 ESSE 1125



 Score = 34.7 bits (78), Expect = 0.96
 Identities = 40/223 (17%), Positives = 88/223 (39%), Gaps = 6/223 (2%)

Query: 1197 KAGRKPKIQESEETVEPKEDMPLPEE--RKEEEEMQAEAEEAEEGEEEDAASSEVPAASP 1254
            K  RK K   S    + K+          K++ + Q+E+   +   E++  S     A+ 
Sbjct: 738  KGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAAR 797

Query: 1255 ADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDH 1314
                  P T+  +   +E+  K  +  +  ++ +  QE    + E +++   ET  + + 
Sbjct: 798  TTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQE--RETFSSAEG 855

Query: 1315 DAD-DEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDS 1373
              D D     L     K+ +   + + V +  G ++SF    ++K  E  K+K +     
Sbjct: 856  TVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAE-TKEKSKHLKTK 914

Query: 1374 EEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIP 1416
              ++     S ++E+    +   E     K++  +  EE++ P
Sbjct: 915  TCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKP 957



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 33/139 (23%), Positives = 59/139 (42%), Gaps = 26/139 (18%)

Query: 783  NSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVS 842
            N   SEEEEEE EE E EE + +E E           E++  DS S           P  
Sbjct: 1400 NKSNSEEEEEEKEEEEEEEEEEEEEE-----------EDENDDSKS-----------PGK 1437

Query: 843  STRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGEC 902
              +  +++L  D L   +Q + +    R+ R  +     +  + ++E   ++P     +C
Sbjct: 1438 GRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPT----KC 1493

Query: 903  GEKSEATQEQYTESEEQLV 921
               ++   ++  E++E LV
Sbjct: 1494 PITTKLVLDEDEETKEPLV 1512


>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
          Length = 2492

 Score = 85.1 bits (209), Expect = 6e-16
 Identities = 137/658 (20%), Positives = 254/658 (38%), Gaps = 91/658 (13%)

Query: 806  ERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQ--PS 863
            E+ L+       S ++K+Q     E +KKP         ++ K    ++S    ++  P 
Sbjct: 966  EKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDF----KKKVIKMEQQYESSSDGTEKLPE 1021

Query: 864  RRGRW----GRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEATQEQYTESEEQ 919
            R        G K  K     G+K SK + ++TS   +++  +  EKS       T   + 
Sbjct: 1022 REEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKK-KDELSDYAEKS-------TGKGDS 1073

Query: 920  LVASEEQPSQDGKPDLPKRRLSE-GVEPWRGQLKKSPEALKCRLTE-GSERLPRRYSEGD 977
              +SE++ S++G     K+R    G    + Q   S +  K  + E G     +R    +
Sbjct: 1074 CDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIE 1133

Query: 978  RAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTET 1037
                R  S     +E      SS     ++   K+K+    +++ V  ++   +S+ T T
Sbjct: 1134 LRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTST 1193

Query: 1038 ISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQ 1097
              +  ++      D         +E   +    E   DE ++ P      LSS       
Sbjct: 1194 KRKQADITSSSSSD---------IEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQS 1244

Query: 1098 SSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVK-NSPLEPDTSTPLKKKKGWPKGK 1156
            S  +  SK      + DD D+ P  +    +   ++K N   + D S+  + ++G     
Sbjct: 1245 SGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEG----- 1299

Query: 1157 SRKPIHWKKRPGRK----PGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQE------ 1206
                   KKR G++    PG + ++  +   +         S  +  +KP+ +       
Sbjct: 1300 -------KKRTGKQNEENPGDEEAKNQVNSESD--------SDSEESKKPRYRHRLLRHK 1344

Query: 1207 ---------SEETVEPKEDMPLP--EERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPA 1255
                      E+  +PKE   +     RK   E   +++  E G  E+ + SE       
Sbjct: 1345 LTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRT 1404

Query: 1256 DSSNSPETETKEPEVEEEEEKPRV-------SEEQRQSEEEQQELEEPEPEEEEDAAAET 1308
             S+   E E  +   ++++++ R+       SE +  SEEE++E EE E EEEE+   E 
Sbjct: 1405 RSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEE 1464

Query: 1309 AQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEE 1368
             +NDD  +  +    +    K +     T+  +KEE   ++    A  ++ REK+++  E
Sbjct: 1465 DENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRI--AEREREREKLREVIE 1522

Query: 1369 TELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQ 1426
             E  S  + P     V+           +ED  TKE L+++     I      ++ VQ
Sbjct: 1523 IEDASPTKCPITTKLVL-----------DEDEETKEPLVQVHRNMVIKLKPHQVDGVQ 1569



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 68/364 (18%), Positives = 137/364 (37%), Gaps = 27/364 (7%)

Query: 1098 SSSKRKSKDEEEDEESDDADDTPILKPVSLLR--KRDVKNSPLEPDTSTPLKKKKGWPKG 1155
            S  KR+++ E  + +S+   +   +  +   R  K+ + N+  + D+S   K  K     
Sbjct: 804  SKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTK-DFDSSEDEKHSKKGMDN 862

Query: 1156 KSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKE 1215
            +  K +   +        +        S +  V +    +    R PK Q++  + +  +
Sbjct: 863  QGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVD 922

Query: 1216 DMPLPEERKEEEEMQAEAEEAEEGEE---------EDAASSEVPAASPADSSNSPETETK 1266
             +   E+     E++  AE  E+ +          +D  S         D S+    + K
Sbjct: 923  KLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDK 982

Query: 1267 EPEVEEEEEKPRVSEEQRQSEEEQQELE------EPEPEEEE----DAAAETAQNDDHDA 1316
            +   +  EEK + S+ +++  + +Q+ E      E  PE EE        +  +N   D 
Sbjct: 983  KQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDG 1042

Query: 1317 DDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKI--KDKEETELDSE 1374
            + +     + T KK+ E     E   +  G  +S   +  +KS+     ++K+  +L  +
Sbjct: 1043 EKKSKKIRDKTSKKKDELSDYAE---KSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGK 1099

Query: 1375 EEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQE 1434
              +   D S    +    ++D    S  + + IEL+E   +       E      S   E
Sbjct: 1100 SSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAE 1159

Query: 1435 ESSE 1438
            ESSE
Sbjct: 1160 ESSE 1163



 Score = 36.6 bits (83), Expect = 0.25
 Identities = 43/173 (24%), Positives = 68/173 (39%), Gaps = 15/173 (8%)

Query: 1233 AEEAEEGEEEDA----ASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEE 1288
            A  +EE EE  +    A ++         SNS   E  + E     EK + S   R   +
Sbjct: 23   AHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRK 82

Query: 1289 EQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQ 1348
                 +  E ++E+    ET   D  + + E+D  ++S  K  +  QP       EP + 
Sbjct: 83   PSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKGTVIVQP-------EPVLN 135

Query: 1349 ESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDH-EEDS 1400
            E   D    + R + K K E  L    E   H   +VS    G + +H ++DS
Sbjct: 136  EDKDDFKGPEFRSRSKMKTE-NLKKRGEDGLH--GIVSCTACGQQVNHFQKDS 185



 Score = 34.7 bits (78), Expect = 0.96
 Identities = 40/223 (17%), Positives = 88/223 (39%), Gaps = 6/223 (2%)

Query: 1197 KAGRKPKIQESEETVEPKEDMPLPEE--RKEEEEMQAEAEEAEEGEEEDAASSEVPAASP 1254
            K  RK K   S    + K+          K++ + Q+E+   +   E++  S     A+ 
Sbjct: 776  KGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAAR 835

Query: 1255 ADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDH 1314
                  P T+  +   +E+  K  +  +  ++ +  QE    + E +++   ET  + + 
Sbjct: 836  TTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQE--RETFSSAEG 893

Query: 1315 DAD-DEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDS 1373
              D D     L     K+ +   + + V +  G ++SF    ++K  E  K+K +     
Sbjct: 894  TVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAE-TKEKSKHLKTK 952

Query: 1374 EEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIP 1416
              ++     S ++E+    +   E     K++  +  EE++ P
Sbjct: 953  TCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKP 995



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 33/139 (23%), Positives = 59/139 (42%), Gaps = 26/139 (18%)

Query: 783  NSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVS 842
            N   SEEEEEE EE E EE + +E E           E++  DS S           P  
Sbjct: 1438 NKSNSEEEEEEKEEEEEEEEEEEEEE-----------EDENDDSKS-----------PGK 1475

Query: 843  STRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGEC 902
              +  +++L  D L   +Q + +    R+ R  +     +  + ++E   ++P     +C
Sbjct: 1476 GRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPT----KC 1531

Query: 903  GEKSEATQEQYTESEEQLV 921
               ++   ++  E++E LV
Sbjct: 1532 PITTKLVLDEDEETKEPLV 1550


>gi|114431236 zinc finger protein 462 [Homo sapiens]
          Length = 2506

 Score = 84.7 bits (208), Expect = 8e-16
 Identities = 52/108 (48%), Positives = 57/108 (52%), Gaps = 8/108 (7%)

Query: 1611 SMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAP 1670
            S   S S      V    + SI   +S V+  P   QQQQPP PPP  P PPP QPQP  
Sbjct: 504  SQSESISSSLNEGVVSYESSSINGRKSGVMLDPL--QQQQPPQPPPPPPPPPPSQPQPLQ 561

Query: 1671 QPPPPQQQPQQQPQPQPQ-QPPP---PPPPQQQPPLS--QCSMNNSFT 1712
            QP PPQ QP  Q  PQPQ QPPP   P PP Q  PL   +C+M N  T
Sbjct: 562  QPQPPQLQPPHQVPPQPQTQPPPTQQPQPPTQAAPLHPYKCTMCNYST 609



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 20/49 (40%), Positives = 21/49 (42%)

Query: 1673 PPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIP 1721
            P  QQQP Q P P P  PP  P P QQP   Q    +   P P     P
Sbjct: 536  PLQQQQPPQPPPPPPPPPPSQPQPLQQPQPPQLQPPHQVPPQPQTQPPP 584



 Score = 37.4 bits (85), Expect = 0.15
 Identities = 34/105 (32%), Positives = 44/105 (41%), Gaps = 11/105 (10%)

Query: 1579 GNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCS------MMQQSSVQPAANCSI 1632
            G +S   + +    S SSSL +   VV+ + +S+    S      + QQ   QP      
Sbjct: 494  GTTSDWDAVNSQSESISSSLNEG--VVSYESSSINGRKSGVMLDPLQQQQPPQPPPPPPP 551

Query: 1633 KSPQSCVVERPPSNQQQQPPP--PPPQQPQPPP-PQPQPAPQPPP 1674
              P      + P   Q QPP   PP  Q QPPP  QPQP  Q  P
Sbjct: 552  PPPSQPQPLQQPQPPQLQPPHQVPPQPQTQPPPTQQPQPPTQAAP 596



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 77/418 (18%), Positives = 150/418 (35%), Gaps = 69/418 (16%)

Query: 1297 EPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVK-------------- 1342
            + +++EDA      N + D ++E+D  +E   + + EE+PT   ++              
Sbjct: 709  QTKQQEDAVI----NVEDDEEEEEDNEVEIEVELDREEEPTEPIIEVPTSFSAQQIWVRD 764

Query: 1343 -EEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMA----------- 1390
              EP  + +F +     +     + E T  + EE+     T++   Q++           
Sbjct: 765  TSEPQKEPNFRNITHDYNATNGAEIELTLSEDEEDYYGSSTNLKDHQVSNTALLNTQTPI 824

Query: 1391 -GSEDDHEE-DSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQ---D 1445
             G+E + E  D      L   K      H + + ++ ++V +  Q      + +++   D
Sbjct: 825  YGTEHNSENTDFGDSGRLYYCK------HCDFNNKSARSVSTHYQRMHPYIKFSFRYILD 878

Query: 1446 CEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQS--HPSQSVR----SVSS 1499
              +  A  + L+ Y        +      H  EH+    +V +  H     R    S +S
Sbjct: 879  PNDHSAVYRCLECYIDYTNFEDLQQ----HYGEHHPEAMNVLNFDHSDLIYRCRFCSYTS 934

Query: 1500 PNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIEST 1559
            PNV +L   Y ++ P     +A    +        + + S   +++++S   ++ +    
Sbjct: 935  PNVRSLMPHYQRMHPTVKINNAMIFSSYVVEQQEGLNTESQTLREILNSAPKNMATSTPV 994

Query: 1560 TENYENPSSYDSTMGGSICGNSSSQSS-------------CSYGGLSSSSSLTQSSCVVT 1606
                  P++++     +      +Q               CS+   +  S L        
Sbjct: 995  ARGGGLPATFNKNTPKTFTPECENQKDPLVNTVVVYDCDVCSFASPNMHSVLVHYQKKHP 1054

Query: 1607 QQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPP 1664
            ++ AS       M+  SV      S  S  S  V  P S +      PPP  PQPPPP
Sbjct: 1055 EEKASYFRIQKTMRMVSVDRG---SALSQLSFEVGAPMSPKMSNMGSPPP--PQPPPP 1107



 Score = 31.6 bits (70), Expect = 8.2
 Identities = 23/88 (26%), Positives = 41/88 (46%), Gaps = 6/88 (6%)

Query: 1352 LDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEEL-IELK 1410
            LD +  K R +I      E+ S  +   + T    + +   EDD EE+   + E+ +EL 
Sbjct: 685  LDLSPVKKRTRID-----EIASNLQSKINQTKQQEDAVINVEDDEEEEEDNEVEIEVELD 739

Query: 1411 EEEEIPHSELDLETVQAVQSLTQEESSE 1438
             EEE     +++ T  + Q +   ++SE
Sbjct: 740  REEEPTEPIIEVPTSFSAQQIWVRDTSE 767


>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
          Length = 2817

 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 193/946 (20%), Positives = 336/946 (35%), Gaps = 161/946 (17%)

Query: 834  KPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSS 893
            +PE  + +S++ L K++   D+L A +     G     +   Q  F D D     E+ S+
Sbjct: 290  EPERPSILSASEL-KELDKFDNLDAEADEGWAGAQMEVDYTEQLNFSDDD-----EQGSN 343

Query: 894  APQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKK 953
            +P+E   E  + S+A++    + E   V++ +  SQ     +P +     V   +G    
Sbjct: 344  SPKENNSE-DQGSKASENNENKKETDEVSNTKSSSQ-----IPAQPSVAKVPYGKGPSFN 397

Query: 954  SPEALKCRLTEGSERLPRRYSEGDRAVLRGF-------SESSEEEEEPESPRSSSPPILT 1006
                    L    + L +++   DR  + G         + ++E+E  +  R     I  
Sbjct: 398  QERGTSSHLPPPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRRRQQSEISA 457

Query: 1007 KPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFE 1066
                 RK+     RR   +RK           +E  + LDE     + +   P  E   E
Sbjct: 458  AVERARKRREEEERRMEEQRK--------AACAEKLKRLDEKLGILEKQ---PSPEEIRE 506

Query: 1067 IDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVS 1126
             + E+E E E EL   +             Q   K + KD E  +E +            
Sbjct: 507  REREKEREREKELEKEQE------------QEREKEREKDRERQQEKEKE---------- 544

Query: 1127 LLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQA 1186
             L K   K   +E +     +K+    K K ++    K++                  + 
Sbjct: 545  -LEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQE-----------------KE 586

Query: 1187 CVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAAS 1246
            C +E            + ++ EE +EP+E    P   K+E E     EE      +D+  
Sbjct: 587  CELEK-----------EREKLEEKIEPREPNLEPMVEKQESENSCNKEEEPVFTRQDSNR 635

Query: 1247 SEVPAASPADSSNSPETETK-EPEVE----EEEEKPRVSEEQRQSEEEQQELEEPEPEEE 1301
            SE   A+P      PE+ ++  P V     ++ +K      QRQ E+ +Q+  + + +++
Sbjct: 636  SE-KEATPVVHETEPESGSQPRPAVLSGYFKQFQKSLPPRFQRQQEQMKQQ--QWQQQQQ 692

Query: 1302 EDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPG--VQESFLDANMQKS 1359
            +    +T  +    +      H    +  +   Q     +  +P   + +S++D  M   
Sbjct: 693  QGVLPQTVPSQPSSSTVPPPPHRPLYQPMQPHPQHLAS-MGFDPRWLMMQSYMDPRMMSG 751

Query: 1360 REK----------IKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIEL 1409
            R            I  K     D  E  P+   S   E +A S  DH   + +  E   L
Sbjct: 752  RPAMDIPPIHPGMIPPKPLMRRDQMEGSPNSSESF--EHIARSARDH---AISLSEPRML 806

Query: 1410 KEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMS 1469
               +  PH+E    T       T+E       A  D E+  AA      + Q +  P+  
Sbjct: 807  WGSDPYPHAEPQQATTPKA---TEEPEDVRSEAALDQEQITAAYSV--EHNQLEAHPKAD 861

Query: 1470 MVEDCHASEHNSPISSVQSHPSQSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQNM-- 1527
             + +       S  + VQ   S+SV  V   +  A        +P+Q +LSAP  + +  
Sbjct: 862  FIRE-------SSEAQVQKFLSRSVEDVRPHHTDANNQSACFEAPDQKTLSAPQEERISA 914

Query: 1528 ---ETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTT-------ENYENPSSYDSTMGGSI 1577
               + S    V   S+H+Q+  +        I   T       E  E P       G   
Sbjct: 915  VESQPSRKRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEKPKKEGFIR 974

Query: 1578 CGNS-------SSQSSCSYGGLSSSSS--------LTQSSCVVTQQMASMGSSCSMMQQS 1622
                        S+S   +G   SS+         + +S  +    +  M       ++ 
Sbjct: 975  SSEGPKPEKVYKSKSETRWGPRPSSNRREEVNDRPVRRSGPIKKPVLRDMKEEREQRKEK 1034

Query: 1623 SVQPAANCSIKSPQSCVVERPPSNQQQQ--PPPPPPQQPQPPPPQPQPAPQPPPPQQQPQ 1680
              + A   + K     VV +P   +++   PPPPPPQ P P  PQ  P P  P  ++ P 
Sbjct: 1035 EGEKAEKVTEK-----VVVKPEKTEKKDLPPPPPPPQPPAPIQPQSVPPPIQPEAEKFPS 1089

Query: 1681 -------QQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIME 1719
                   Q+P    ++P  P    Q  P  + ++N     AP++ E
Sbjct: 1090 TETATLAQKPSQDTEKPLEPVSTVQVEPAVK-TVNQQTMAAPVVKE 1134



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 115/526 (21%), Positives = 217/526 (41%), Gaps = 59/526 (11%)

Query: 1037 TISETTEVL----DEPFEDSDSERP-------MPRLEPTFEIDEEEEEEDENELFPREYF 1085
            ++SET + L      P   S+ ERP       +  L+    +D E +E         +Y 
Sbjct: 270  SLSETNKGLRGRGPPPSWASEPERPSILSASELKELDKFDNLDAEADEGWAGAQMEVDYT 329

Query: 1086 RRLS-SQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTST 1144
             +L+ S D  +  +S K  + +++  + S++ ++      VS     + K+S   P  + 
Sbjct: 330  EQLNFSDDDEQGSNSPKENNSEDQGSKASENNENKKETDEVS-----NTKSSSQIP--AQ 382

Query: 1145 PLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKI 1204
            P   K  + KG S             P   L+++  P   QA    P       G  P  
Sbjct: 383  PSVAKVPYGKGPSFNQERGTSSHLPPPPKLLAQQHPPPDRQAVPGRP-------GPFPSK 435

Query: 1205 QESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEG-EEEDAASSEVPAASPADSSNSPET 1263
            Q+  +     ED    + R+++ E+ A  E A +  EEE+    E   A+ A+     + 
Sbjct: 436  QQVAD-----EDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDE 490

Query: 1264 ET----KEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDE 1319
            +     K+P  EE  E+ R  E +R+ E E+++ +E E E E+D   +  +  + + + E
Sbjct: 491  KLGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQE 550

Query: 1320 DDGHLESTKKKELEEQPTREDVKEEP--GVQESFLDANMQKSREKIKDKEETELDSEEEQ 1377
                +E  +K+E E++  R+  KE+    ++E   +  ++K REK+++K       E  +
Sbjct: 551  KQREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEK------IEPRE 604

Query: 1378 PSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESS 1437
            P+ +  V  ++   S +  EE   T+++    ++E      E + E      S +Q   +
Sbjct: 605  PNLEPMVEKQESENSCNKEEEPVFTRQDSNRSEKEATPVVHETEPE------SGSQPRPA 658

Query: 1438 EHEGAYQDCEETL----AACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQS 1493
               G ++  +++L       Q      Q  +  Q  ++     S+ +S  S+V   P + 
Sbjct: 659  VLSGYFKQFQKSLPPRFQRQQEQMKQQQWQQQQQQGVLPQTVPSQPSS--STVPPPPHRP 716

Query: 1494 VRSVSSPNVPALES-GYTQISPEQGSLSAPSMQNMETSPMMDVPSV 1538
            +     P+   L S G+        S   P M  M   P MD+P +
Sbjct: 717  LYQPMQPHPQHLASMGFDPRWLMMQSYMDPRM--MSGRPAMDIPPI 760



 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 151/820 (18%), Positives = 308/820 (37%), Gaps = 95/820 (11%)

Query: 949  GQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKP 1008
            G L++  E+     +   E +P+R  +      RG SE+  + E  ES  +S    L+K 
Sbjct: 1234 GPLRQREESETRSESSDFEVVPKRRRQ------RG-SETDTDSEIHES--ASDKDSLSKG 1284

Query: 1009 TLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPF-EDSDSERP--MPRLEPTF 1065
             L +++     ++ V   K H+S      +     +L++P+  D D  +P  +P+ EPT 
Sbjct: 1285 KLPKREERPENKKPV---KPHSSFKPDNHVRIDNRLLEKPYVRDDDKAKPGFLPKGEPTR 1341

Query: 1066 EIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSK-DEEEDEESDDADDTPILKP 1124
                        +   R        +   R    + R+S+  + ED E     +  I  P
Sbjct: 1342 RGRGGTFRRGGRDPGGRPSRPSTLRRPAYRDNQWNPRQSEVPKPEDGEPPRRHEQFI--P 1399

Query: 1125 VSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVST 1184
            ++  ++        +P    P +++   P  +  KP  +++   R+   K S E++ V T
Sbjct: 1400 IAADKRPPKFERKFDPARERPRRQRPTRPP-RQDKPPRFRRLREREAASK-SNEVVAVPT 1457

Query: 1185 QACVI----EPIVSIP--KAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEE 1238
               V     EP+ ++      + P +     + +  E+     E  +  E +      E 
Sbjct: 1458 NGTVNNVAQEPVNTLGDISGNKTPDLSNQNSSDQANEEWETASESSDFNERR------ER 1511

Query: 1239 GEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQ-QELEEPE 1297
             E+++A  +        ++   P+ E  +     +    R +        +  +    P 
Sbjct: 1512 DEKKNADLNAQTVVKVGENVLPPKREIAKRSFSSQRPVDRQNRRGNNGPPKSGRNFSGPR 1571

Query: 1298 PEEEEDAAAETAQN---DDHDADDEDDGHLESTKKKELEEQPT---REDVKEEPGVQESF 1351
             E      +++ +    DD  A       +  +     E  P    +++ K+  G +   
Sbjct: 1572 NERRSGPPSKSGKRGPFDDQPAGTTGVDLINGSSAHHQEGVPNGTGQKNSKDSTGKKRED 1631

Query: 1352 LDANMQKSREKIKDKEETELDSE------EEQPSHDTSVVSEQMAGSEDDHEEDSHTKEE 1405
                 +K +EK+    + +L++       ++ P  + +V+ +  +   DD   +  +K++
Sbjct: 1632 PKPGPKKPKEKVDALSQFDLNNYASVVIIDDHP--EVTVIEDPQSNLNDDGFTEVVSKKQ 1689

Query: 1406 LIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADED 1465
               L++EE     E      Q +Q   ++ ++E +G  Q  +      +           
Sbjct: 1690 QKRLQDEERRKKEE------QVIQVWNKKNANE-KGRSQTSKLPPRFAKK---------- 1732

Query: 1466 PQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQ 1525
             Q + ++   +S    P++S    PS S    +S + P   +    ++P   S SAP   
Sbjct: 1733 -QATGIQQAQSSASVPPLASAPLPPSTSASVPASTSAPLPAT----LTPVPASTSAP--- 1784

Query: 1526 NMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNSSSQS 1585
             +  S +   P ++  S  V  S  + + +  S + +        ST   +I  +S+  S
Sbjct: 1785 -VPASTL--APVLASTSAPVPASPLAPVSASASVSASVPA-----STSAAAITSSSAPAS 1836

Query: 1586 SCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERP-- 1643
            + +   + +S S   S  ++      + +S ++   S+  PA   S  SP + V+  P  
Sbjct: 1837 APAPTPILASVSTPASVTILASASIPILAS-ALASTSAPTPAPAAS--SPAAPVITAPTI 1893

Query: 1644 PSNQQQQPPPPPPQQPQPPPPQPQPA----PQPPPPQQ------QPQQQPQPQPQQPPPP 1693
            P++      P  P     P P P P     P PP P Q      +P Q P     Q    
Sbjct: 1894 PASAPTASVPLAPASASAPAPAPTPVSAPNPAPPAPAQTQAQTHKPVQNPLQTTSQSSKQ 1953

Query: 1694 PPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYE 1733
            PPP  + P +Q      +  +   ++ P+S  T    +++
Sbjct: 1954 PPPSIRLPSAQTPNGTDYVASGKSIQTPQSHGTLTAELWD 1993



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 228/1186 (19%), Positives = 392/1186 (33%), Gaps = 170/1186 (14%)

Query: 792  EEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVL 851
            EE E+  +E    QE   +I+   SV H   E    +    +  E       +R  + V 
Sbjct: 827  EEPEDVRSEAALDQE---QITAAYSVEHNQLEAHPKADFIRESSEAQVQKFLSRSVEDVR 883

Query: 852  PHDSLPANSQPSRRGRWGRKNRKT--QERFGDKDSKLLLEETSS-------APQEQYGEC 902
            PH +  AN+Q +      +K      +ER    +S+   + + S        P EQ  E 
Sbjct: 884  PHHT-DANNQSACFEAPDQKTLSAPQEERISAVESQPSRKRSVSHGSNHTQKPDEQRSEP 942

Query: 903  GEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKS-----PEA 957
                     +  +S+E +   EE+P ++G       R SEG +P +    KS     P  
Sbjct: 943  SAGIPKVTSRCIDSKEPIERPEEKPKKEG-----FIRSSEGPKPEKVYKSKSETRWGPRP 997

Query: 958  LKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSS--SPPILTKPTLKRKKP 1015
               R  E ++R  RR     + VLR   E  E+ +E E  ++   +  ++ KP    KK 
Sbjct: 998  SSNRREEVNDRPVRRSGPIKKPVLRDMKEEREQRKEKEGEKAEKVTEKVVVKPEKTEKKD 1057

Query: 1016 FLHRRRRVRKRKHHNSSVVTETI---------SETTEVLDEPFEDSDSERPMPRLEPTFE 1066
                    +         V   I         +ET  +  +P    D+E+P   LEP   
Sbjct: 1058 LPPPPPPPQPPAPIQPQSVPPPIQPEAEKFPSTETATLAQKP--SQDTEKP---LEPVST 1112

Query: 1067 IDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVS 1126
            +  E   +  N                   Q +       EE+  E   + D  I +P  
Sbjct: 1113 VQVEPAVKTVN-------------------QQTMAAPVVKEEKQPEKVISKDLVIERPRP 1153

Query: 1127 LLRKRDVKNSPLEPDTSTPLKKKKGW-----PKGKSRKPIHWKKRPGR-------KPGFK 1174
              R    K S L P T     +++ W      +G+ R   + + R  R       + G  
Sbjct: 1154 DSRPAVKKESTLPPRTYWKEARERDWFPDQGYRGRGRGEYYSRGRSYRGSYGGRGRGGRG 1213

Query: 1175 LSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEE-EEMQAEA 1233
             +R+           E I S P   R    +ESE   E  +   +P+ R++   E   ++
Sbjct: 1214 HTRDYPQYRDNKPRAEHIPSGPLRQR----EESETRSESSDFEVVPKRRRQRGSETDTDS 1269

Query: 1234 EEAEEGEEEDAAS-SEVPAASPADSSNSPETETKEPEVEEEEEKP--------RVSEEQR 1284
            E  E   ++D+ S  ++P             E K+P       KP        R+ E+  
Sbjct: 1270 EIHESASDKDSLSKGKLP-------KREERPENKKPVKPHSSFKPDNHVRIDNRLLEKPY 1322

Query: 1285 QSEEEQQE---LEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDV 1341
              ++++ +   L + EP              D          L     ++ +  P + +V
Sbjct: 1323 VRDDDKAKPGFLPKGEPTRRGRGGTFRRGGRDPGGRPSRPSTLRRPAYRDNQWNPRQSEV 1382

Query: 1342 -KEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSV-------------VSE 1387
             K E G      +  +  + +K   K E + D   E+P                   + E
Sbjct: 1383 PKPEDGEPPRRHEQFIPIAADKRPPKFERKFDPARERPRRQRPTRPPRQDKPPRFRRLRE 1442

Query: 1388 QMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCE 1447
            + A S+ +      T   +  + +E   P + L   +      L+ + SS+      +  
Sbjct: 1443 REAASKSNEVVAVPTNGTVNNVAQE---PVNTLGDISGNKTPDLSNQNSSDQA---NEEW 1496

Query: 1448 ETLAACQTLQSYTQADEDPQMSMVEDCHASEHNS---PISSVQSHPSQSVRSVSSPNVPA 1504
            ET +         + DE     +          +   P   +      S R V   N   
Sbjct: 1497 ETASESSDFNERRERDEKKNADLNAQTVVKVGENVLPPKREIAKRSFSSQRPVDRQNRRG 1556

Query: 1505 ----LESGYTQISPEQGSLSAPSMQNMETSPMMDVPS----------VSDHSQQVVDSGF 1550
                 +SG     P     S P  ++ +  P  D P+           S H Q+ V +G 
Sbjct: 1557 NNGPPKSGRNFSGPRNERRSGPPSKSGKRGPFDDQPAGTTGVDLINGSSAHHQEGVPNGT 1616

Query: 1551 SDLGSIESTTENYENP--------------SSYDSTMGGS---------ICGNSSSQSSC 1587
                S +ST +  E+P              S +D     S         +      QS+ 
Sbjct: 1617 GQKNSKDSTGKKREDPKPGPKKPKEKVDALSQFDLNNYASVVIIDDHPEVTVIEDPQSNL 1676

Query: 1588 SYGGLSSSSSLTQSSCVVTQQMASMGSSCSMM--QQSSVQPAANCSIKSPQSCVVERPPS 1645
            +  G +   S  Q   +  ++          +  ++++ +   + + K P     ++   
Sbjct: 1677 NDDGFTEVVSKKQQKRLQDEERRKKEEQVIQVWNKKNANEKGRSQTSKLPPRFAKKQATG 1736

Query: 1646 NQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQC 1705
             QQ Q     P     P P    A  P            P P     P P     P+   
Sbjct: 1737 IQQAQSSASVPPLASAPLPPSTSASVPASTSAPLPATLTPVPASTSAPVPASTLAPV--- 1793

Query: 1706 SMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMD 1765
             + ++  P P     P S S    S+   +P    A + +  SA  S      +  ++  
Sbjct: 1794 -LASTSAPVPASPLAPVSASA---SVSASVPASTSAAAITSSSAPASAPAPTPILASVST 1849

Query: 1766 PHAMPYSHS---PAVTSYATSVSLSNTGLAQLAPSHPLAGTPQAQATM-TPPPNLASTTM 1821
            P ++    S   P + S   S S      A  +P+ P+   P   A+  T    LA  + 
Sbjct: 1850 PASVTILASASIPILASALASTSAPTPAPAASSPAAPVITAPTIPASAPTASVPLAPASA 1909

Query: 1822 NLTSPLLQCNMSATNIGIPHTQRLQGQ--MPVKGHISIRSKSAPLP 1865
            +  +P     +SA N   P   + Q Q   PV+  +   S+S+  P
Sbjct: 1910 SAPAP-APTPVSAPNPAPPAPAQTQAQTHKPVQNPLQTTSQSSKQP 1954



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 112/607 (18%), Positives = 216/607 (35%), Gaps = 83/607 (13%)

Query: 786  VSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEV---MAPVS 842
            + E E E+  E E E  + QE+E E    K    + +++     E EK+ E+        
Sbjct: 504  IREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEK 563

Query: 843  STRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGEC 902
               L +Q      L    +  +     ++  K +E+   ++  L   E     QE    C
Sbjct: 564  EKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNL---EPMVEKQESENSC 620

Query: 903  GEKSEA--TQEQYTESEEQL--VASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEAL 958
             ++ E   T++    SE++   V  E +P    +P               G  K+  ++L
Sbjct: 621  NKEEEPVFTRQDSNRSEKEATPVVHETEPESGSQP---------RPAVLSGYFKQFQKSL 671

Query: 959  KCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSS-PPILTKPTLKRKKPFL 1017
              R     E++ ++  +  +       +    +  P  P SS+ PP   +P  +  +P  
Sbjct: 672  PPRFQRQQEQMKQQQWQQQQ------QQGVLPQTVPSQPSSSTVPPPPHRPLYQPMQP-- 723

Query: 1018 HRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERP-MPRLEPTFEIDEEEEEEDE 1076
               + +         ++ ++  +   +   P  D     P M   +P    D+ E   + 
Sbjct: 724  -HPQHLASMGFDPRWLMMQSYMDPRMMSGRPAMDIPPIHPGMIPPKPLMRRDQMEGSPNS 782

Query: 1077 NELF------PREYFRRLSSQDVL---------RCQSSSKRKSKDEEEDEESDDADDTPI 1121
            +E F       R++   LS   +L           Q ++  K+ +E ED  S+ A D   
Sbjct: 783  SESFEHIARSARDHAISLSEPRMLWGSDPYPHAEPQQATTPKATEEPEDVRSEAALDQEQ 842

Query: 1122 LKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMP 1181
            +     +    ++  P           K  + +  S   +       +K   +   ++ P
Sbjct: 843  ITAAYSVEHNQLEAHP-----------KADFIRESSEAQV-------QKFLSRSVEDVRP 884

Query: 1182 VSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEE 1241
              T A         P   +K      EE +   E  P           ++ +  +   ++
Sbjct: 885  HHTDANNQSACFEAP--DQKTLSAPQEERISAVESQP--------SRKRSVSHGSNHTQK 934

Query: 1242 EDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEE 1301
             D   SE  A  P  +S     ++KEP +E  EEKP+     R S       E P+PE+ 
Sbjct: 935  PDEQRSEPSAGIPKVTSRC--IDSKEP-IERPEEKPKKEGFIRSS-------EGPKPEKV 984

Query: 1302 EDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSRE 1361
              + +ET       ++  ++ +    ++    ++P   D+KEE   ++       +K  E
Sbjct: 985  YKSKSETRWGPRPSSNRREEVNDRPVRRSGPIKKPVLRDMKEEREQRKEKEGEKAEKVTE 1044

Query: 1362 KIKDKEE 1368
            K+  K E
Sbjct: 1045 KVVVKPE 1051



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 157/774 (20%), Positives = 263/774 (33%), Gaps = 136/774 (17%)

Query: 1233 AEEAEEGEEE--DAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQ 1290
            +E A+ G+E   +  +  +   +PA + N            E E  P +SE+      E 
Sbjct: 2036 SEGAKNGQESGLEIGTDTIQFGAPASNGN------------ENEVVPVLSEKSADKIPEP 2083

Query: 1291 QELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQES 1350
            +E  + +P                       G +++ K  +L     +E      G + S
Sbjct: 2084 KEQRQKQPRA---------------------GPIKAQKLPDLSPVENKEHKPGPIGKERS 2122

Query: 1351 FLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELK 1410
                       K+KD ++ E + +E+ PS  T   ++ +   E     +  T     E+ 
Sbjct: 2123 L-------KNRKVKDAQQVEPEGQEK-PSPATVRSTDPVTTKETKAVSEMST-----EIG 2169

Query: 1411 EEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQD---CEETLAACQTLQSYTQADEDPQ 1467
                +  +E      ++V   T   SS       +    E+TL     L +       P+
Sbjct: 2170 TMISVSSAEYGTNAKESVTDYTTPSSSLPNTVATNNTKMEDTLVNNVPLPNTLPL---PK 2226

Query: 1468 MSMVEDCHASEHNSPISSVQSHPSQSVRSV--SSPNVPALESGYTQISPE-----QGSLS 1520
               ++   +     P +   +   +S R    +SPNV    S  T  +P        S S
Sbjct: 2227 RETIQQSSSLTSVPPTTFSLTFKMESARKAWENSPNVREKGSPVTSTAPPIATGVSSSAS 2286

Query: 1521 APSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGN 1580
             PS  N  +     +P +   S     S  S  G+  +++ + ++ ++ D     +IC  
Sbjct: 2287 GPSTANYNSFSSASMPQIPVASVTPTAS-LSGAGTYTTSSLSTKSTTTSDPP---NICKV 2342

Query: 1581 SSSQSSCSYGGLSSSSSLTQSSCVVT-----QQMASMGSSCSMMQQSSVQPAANCSIKSP 1635
               Q   S   L S+S  +Q SC+ +     QQ   +  S S   Q          + + 
Sbjct: 2343 KPQQLQTS--SLPSASHFSQLSCMPSLIAQQQQNPQVYVSQSAAAQIPAFYMDTSHLFNT 2400

Query: 1636 QSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQP-QQQPQPQPQQPPPPP 1694
            Q   +  PPS  QQ       Q  QP   QP    Q P P   P Q Q Q Q      P 
Sbjct: 2401 QHARLA-PPSLAQQ-------QGFQPGLSQPTSVQQIPIPIYAPLQGQHQAQLSLGAGPA 2452

Query: 1695 PPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFGAGSYSQPSATFSLA 1754
              Q Q   S  S    +   P  M+   S S  ++ +      +F    + + +   S  
Sbjct: 2453 VSQAQELFS--SSLQPYRSQPAFMQ--SSLSQPSVVLSGTAIHNFPTVQHQELAKAQSGL 2508

Query: 1755 KLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPLAGTPQAQATMTPPP 1814
              QQ +NT   P  + Y H             S  G +QL  +H L    QA+A +T   
Sbjct: 2509 AFQQTSNT--QPIPILYEHQLG--------QASGLGGSQLIDTHLL----QARANLTQAS 2554

Query: 1815 NL-------------------ASTTMNLTSPLLQCNMSATNIGI---PHTQRLQGQMPVK 1852
            NL                    S    +T PL    +S  N G    P     Q   P  
Sbjct: 2555 NLYSGQVQQPGQTNFYNTAQSPSALQQVTVPLPASQLSLPNFGSTGQPLIALPQTLQPPL 2614

Query: 1853 GHISIRSKSAPLPSAAAHQQQLYGRSPS----AVAMQAGPRALAVQRGMNMGVNLMP--- 1905
             H + ++++  L   A   Q   G  P+    ++    G  +    +    G+++ P   
Sbjct: 2615 QHTTPQAQAQSLSRPAQVSQPFRGLIPAGTQHSMIATTGKMSEMELKAFGSGIDIKPGTP 2674

Query: 1906 -------TPAYNVNSMNMNTLNAMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQ 1952
                   TP  +       + N+ +S +M   +    + S PA +  T  +P Q
Sbjct: 2675 PIAGRSTTPTSSPFRATSTSPNSQSS-KMNSIVYQKQFQSAPATVRMTQPFPTQ 2727



 Score = 37.0 bits (84), Expect = 0.19
 Identities = 102/575 (17%), Positives = 185/575 (32%), Gaps = 85/575 (14%)

Query: 1221 EERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVS 1280
            +E  + + + AEA+E   G     A  EV      + S+  E  +  P+    E++   +
Sbjct: 303  KELDKFDNLDAEADEGWAG-----AQMEVDYTEQLNFSDDDEQGSNSPKENNSEDQGSKA 357

Query: 1281 EEQRQSEEEQQELEEPE-----PEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQ 1335
             E  ++++E  E+   +     P +   A     +    + +     HL    K   ++ 
Sbjct: 358  SENNENKKETDEVSNTKSSSQIPAQPSVAKVPYGKGPSFNQERGTSSHLPPPPKLLAQQH 417

Query: 1336 PTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDD 1395
            P   D +  PG    F       S++++ D++E       +Q     +V   +    E++
Sbjct: 418  PP-PDRQAVPGRPGPF------PSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEE 470

Query: 1396 HEEDSHTK----EELIELKEE----------EEIPHSELDLETVQAVQSLTQEESSEHEG 1441
               +   K    E+L  L E+          EEI   E + E  +  + L +E+  E E 
Sbjct: 471  RRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKER-EREKELEKEQEQERE- 528

Query: 1442 AYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSPN 1501
              ++ E+     Q  +   + +++ Q  M ++    E    +   +    +  +      
Sbjct: 529  --KEREKDRERQQEKEKELEKEQEKQREMEKE-RKQEKEKELERQKEKEKELQKMKEQEK 585

Query: 1502 VPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTE 1561
               LE    ++  +      P   N+E  PM++     +   +  +  F+   S  S  E
Sbjct: 586  ECELEKEREKLEEK----IEPREPNLE--PMVEKQESENSCNKEEEPVFTRQDSNRSEKE 639

Query: 1562 NYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQQ 1621
                    +   G       S        G       +       QQ           QQ
Sbjct: 640  ATPVVHETEPESG-------SQPRPAVLSGYFKQFQKSLPPRFQRQQEQMKQQQWQQQQQ 692

Query: 1622 SSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAP------QPPPP 1675
              V P              +  PS       PPPP +P   P QP P         P   
Sbjct: 693  QGVLP--------------QTVPSQPSSSTVPPPPHRPLYQPMQPHPQHLASMGFDPRWL 738

Query: 1676 QQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERI 1735
              Q    P+    +P    PP                P P++      GS  +   +E I
Sbjct: 739  MMQSYMDPRMMSGRPAMDIPPIHP---------GMIPPKPLMRRDQMEGSPNSSESFEHI 789

Query: 1736 PGDFGAGSYSQPSATFSLAKLQQLTNTIMDPHAMP 1770
                   + S      SL++ + L  +   PHA P
Sbjct: 790  -------ARSARDHAISLSEPRMLWGSDPYPHAEP 817



 Score = 36.2 bits (82), Expect = 0.33
 Identities = 122/672 (18%), Positives = 237/672 (35%), Gaps = 112/672 (16%)

Query: 784  SVVSEEEEEEAEEGENEEPQCQE----RELEISV------------GKSVSHENKEQDSY 827
            S++S  E +E ++ +N + +  E     ++E+              G +   EN  +D  
Sbjct: 295  SILSASELKELDKFDNLDAEADEGWAGAQMEVDYTEQLNFSDDDEQGSNSPKENNSEDQG 354

Query: 828  SVESE--KKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSK 885
            S  SE  +  +    VS+T+ S Q+    S+     P  +G    + R T         K
Sbjct: 355  SKASENNENKKETDEVSNTKSSSQIPAQPSVA--KVPYGKGPSFNQERGTSSHL-PPPPK 411

Query: 886  LLLEETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVE 945
            LL ++    P ++    G       +Q    E+++     +   +    + + R     E
Sbjct: 412  LLAQQ--HPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEE 469

Query: 946  PWRGQLKKSP---EALKCRLTE---------GSERLPRRYSEGDRAVLRGFSESSEEEEE 993
              R + ++     E LK RL E           E +  R  E +R   +   +  E+E E
Sbjct: 470  ERRMEEQRKAACAEKLK-RLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQERE 528

Query: 994  PESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSD 1053
             E               K ++    + + + K +     +  E   E  + L+   E   
Sbjct: 529  KERE-------------KDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEK 575

Query: 1054 SERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEE----- 1108
              + M   E   E+ E+E E+ E ++ PRE     + + ++  Q S    +K+EE     
Sbjct: 576  ELQKMKEQEKECEL-EKEREKLEEKIEPRE----PNLEPMVEKQESENSCNKEEEPVFTR 630

Query: 1109 EDEESDDADDTPIL-----------KPVSL--LRKRDVKNSPLEPDTSTPLKKKKGW--- 1152
            +D    + + TP++           +P  L    K+  K+ P          K++ W   
Sbjct: 631  QDSNRSEKEATPVVHETEPESGSQPRPAVLSGYFKQFQKSLPPRFQRQQEQMKQQQWQQQ 690

Query: 1153 ------PKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQE 1206
                  P+    +P      P          +  P    +   +P   + ++   P++  
Sbjct: 691  QQQGVLPQTVPSQPSSSTVPPPPHRPLYQPMQPHPQHLASMGFDPRWLMMQSYMDPRMMS 750

Query: 1207 SEET-----VEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPA---DSS 1258
                     + P    P P  R+++ E    + E+ E     A    +  + P     S 
Sbjct: 751  GRPAMDIPPIHPGMIPPKPLMRRDQMEGSPNSSESFEHIARSARDHAISLSEPRMLWGSD 810

Query: 1259 NSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADD 1318
              P  E            P+ +   + +EE +    E   ++E+  AA + +++  +A  
Sbjct: 811  PYPHAE------------PQQATTPKATEEPEDVRSEAALDQEQITAAYSVEHNQLEAHP 858

Query: 1319 EDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKS------REKIKDKEETELD 1372
            + D   ES+     E Q  +   +    V+    DAN Q +      ++ +   +E  + 
Sbjct: 859  KADFIRESS-----EAQVQKFLSRSVEDVRPHHTDANNQSACFEAPDQKTLSAPQEERIS 913

Query: 1373 SEEEQPSHDTSV 1384
            + E QPS   SV
Sbjct: 914  AVESQPSRKRSV 925


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 41/103 (39%), Positives = 55/103 (53%), Gaps = 10/103 (9%)

Query: 209 CSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSC 268
           C+ C G  E        +L  C  CG+  H +CL  +  LT R +A  WQC ECK C +C
Sbjct: 229 CAVCEGPGELC------DLFFCTSCGHHYHGACLDTA--LTARKRA-GWQCPECKVCQAC 279

Query: 269 RDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICR 311
           R  G N   ML C++CD+G+H  C  PP+  +P   W C+ CR
Sbjct: 280 RKPG-NDSKMLVCETCDKGYHTFCLKPPMEELPAHSWKCKACR 321



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 31/84 (36%), Positives = 44/84 (52%), Gaps = 3/84 (3%)

Query: 227  LISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDR 286
            L++C+ C    HP C+       + +K   W+C+EC  C  C  Q  +   +L CD CD 
Sbjct: 1394 LLACSQCSQCYHPYCVNSKITKVMLLKG--WRCVECIVCEVC-GQASDPSRLLLCDDCDI 1450

Query: 287  GFHMECCDPPLTRMPKGMWICQIC 310
             +H  C DPPL  +PKG W C+ C
Sbjct: 1451 SYHTYCLDPPLLTVPKGGWKCKWC 1474



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 125/563 (22%), Positives = 200/563 (35%), Gaps = 118/563 (20%)

Query: 1387 EQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDC 1446
            +Q+   +   ++    +++  +L++++++   +L  +  Q  Q L Q++  + +   Q  
Sbjct: 3898 QQLQQQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQ--QQLQQQQQQQLQQQQQQL 3955

Query: 1447 EETLAACQTLQSYTQADEDPQMSMVEDCHA-----SEHNSPISSVQSHPSQSVRSVSSPN 1501
            ++     Q  Q + Q  +  QM ++           +    ++     P++ ++  SSP 
Sbjct: 3956 QQQQQ--QQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPG 4013

Query: 1502 V----------------PALESGYTQ-ISPEQGSLSA--PSMQNMETSPMMDVPSVSDHS 1542
                             PA+ S  T+  S  QG   A   + ++M T P    PS+S  S
Sbjct: 4014 ALGPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDS 4073

Query: 1543 QQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNSSSQSSC-------SYGGLSSS 1595
            Q ++              +    PSS        + G    Q S        S+G L S 
Sbjct: 4074 QLLLVQ-----------PQPQPQPSSLQLQPPLRLPGQQQQQVSLLHTAGGGSHGQLGSG 4122

Query: 1596 SSLTQSSC--VVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQ-QQPP 1652
            SS   SS   ++ Q   S+G     M Q+         +  PQ  ++ERP  N    QPP
Sbjct: 4123 SSSEASSVPHLLAQPSVSLGDQPGSMTQN---------LLGPQQPMLERPMQNNTGPQPP 4173

Query: 1653 PPPP--QQPQPPP--------------------PQPQPAPQPPPPQQQPQ--------QQ 1682
             P P  Q  Q  P                      PQ     P  QQQ Q        QQ
Sbjct: 4174 KPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQ 4233

Query: 1683 PQPQPQQPPPPPPPQQQPPLSQ---CSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDF 1739
             Q   Q PP   P  Q  PL     C       P P    + E G+        R+P   
Sbjct: 4234 SQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPP 4293

Query: 1740 GAGSYSQPSATFSLAKLQQLTNTIMDP-HAMPYSHSPAVTSYATSVSLSNTGL---AQLA 1795
            GA S                T  ++ P H  P   SP      + +   ++ L   AQL 
Sbjct: 4294 GALS----------------TGPVLGPVHPTPPPSSPQEPKRPSQLPSPSSQLPTEAQLP 4337

Query: 1796 PSHPLAGTPQAQA-TMTPPPNLAS-TTMNLTSPLLQCNMSATN--IGIPHTQRLQGQMPV 1851
            P+HP  GTP+ Q  T+ PPP   S     L   L    +   +    +  TQ+ +    V
Sbjct: 4338 PTHP--GTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQKPEQSSLV 4395

Query: 1852 KGHI-SIRSKSAPLPSAAAHQQQ 1873
             GH+  +  +  P  S  + +Q+
Sbjct: 4396 PGHLDQVNGQVVPEASQLSIKQE 4418



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 55/229 (24%), Positives = 85/229 (37%), Gaps = 26/229 (11%)

Query: 1614 SSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPP 1673
            S  S +++S + P      +SP S  +E P S   +  P  PP +  P  P P+  P  P
Sbjct: 510  SPFSPLEESPLSPPE----ESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSP 565

Query: 1674 PPQQQ-----PQQQP-QPQPQQPP--PPP------PPQQQPPLSQCSMNNSFTPAPMIME 1719
            PP+       P++ P  P P++ P  PPP      PP ++ PLS     +  +P P    
Sbjct: 566  PPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASR 625

Query: 1720 IPESGSTGNISIYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTS 1779
            +        +S              S P     L+ L  ++     P   P S  P  + 
Sbjct: 626  LSPPPEDSPMSPPPE------ESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEES- 678

Query: 1780 YATSVSLSNTGLAQLAPSHPLAGTPQAQATMTPPPNLASTTMNLTSPLL 1828
              TS     + L+      P +  P+      PP +   +     SPLL
Sbjct: 679  -PTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLL 726



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 157/721 (21%), Positives = 230/721 (31%), Gaps = 91/721 (12%)

Query: 1150 KGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEE 1209
            +G PKG      H      ++PG  L  E  P+      +EP +  P       + E   
Sbjct: 393  QGQPKGG-----HVTSMQPKEPG-PLQCEAKPLGKAGVQLEPQLEAP-------LNEEMP 439

Query: 1210 TVEPKEDMPL-PEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEP 1268
             + P E+ PL P   +       EA       EE  AS   P       S   E     P
Sbjct: 440  LLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPAS---PLPEALHLSRPLEESPLSP 496

Query: 1269 EVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTK 1328
              EE    P   E    S  E+  L  PE E     A ET  +   +A        ES  
Sbjct: 497  PPEESPLSPP-PESSPFSPLEESPLSPPE-ESPPSPALETPLSPPPEASPLSPPFEESPL 554

Query: 1329 KKELEEQPTR------------EDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEE 1376
                EE PT             E+    P  +ES +    + SR     +E       EE
Sbjct: 555  SPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEE 614

Query: 1377 QPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELD-LETVQAVQSLTQEE 1435
             P       S      ED               +E    P  E+  L  +  V  L+   
Sbjct: 615  SPLSPPPEASRLSPPPEDSPMSPPP--------EESPMSPPPEVSRLSPLPVVSRLSPPP 666

Query: 1436 SSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVR 1495
                     +   T    +  +     ++ P     ED  AS    P  S+ S P +   
Sbjct: 667  EESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASP--PPEDSLMSLPLEESP 724

Query: 1496 SVSSPNVPAL----ESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFS 1551
             +  P  P L    E  +    PE+  LS P  +    SP  + P +S   ++       
Sbjct: 725  LLPLPEEPQLCPRSEGPHLSPRPEEPHLS-PRPEEPHLSPQAEEPHLSPQPEEPCLCAVP 783

Query: 1552 DLGSIESTTENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMAS 1611
                        E P       G  +                  S + +  C+  Q   S
Sbjct: 784  ------------EEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEES 831

Query: 1612 MGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQ 1671
              S  S  ++  + P    S  SP+   +E+PP + + + PP  P Q     P P+  P 
Sbjct: 832  HLSPQS--EEPCLSPRPEESHLSPE---LEKPPLSPRPEKPPEEPGQC----PAPEELPL 882

Query: 1672 PPPPQQQPQQQP---QP---QPQQPPPPPPPQQQP--PLSQCSMNNSFTP----APMIME 1719
             PPP  +P   P   +P   +P +PP  P P++ P  P  + S++    P     P +  
Sbjct: 883  FPPP-GEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSP 941

Query: 1720 IPESGSTGNISIYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTS 1779
            I  + +   +S    +   FGA   S P +  +   L+  T     P A      P    
Sbjct: 942  IITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILE--TPISPPPEANCTDPEPVPPM 999

Query: 1780 YATSVSLSNTGLAQLAPSHPLAGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGI 1839
                   S  G A      PL   PQ        P L  + +   SP  QC+  A  + +
Sbjct: 1000 ILPPSPGSPVGPASPILMEPL--PPQCS------PLLQHSLVPQNSPPSQCSPPALPLSV 1051

Query: 1840 P 1840
            P
Sbjct: 1052 P 1052



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 156/711 (21%), Positives = 230/711 (32%), Gaps = 106/711 (14%)

Query: 1047 EPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQS--SSKRKS 1104
            EP  ++     MP L P  E       E+     P E  R     + L       +   S
Sbjct: 427  EPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLS 486

Query: 1105 KDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWK 1164
            +  EE   S   +++P+  P        ++ SPL P   +P       P      P+   
Sbjct: 487  RPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESP-------PSPALETPL--- 536

Query: 1165 KRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGR-KPKIQESEETVEPKED--MPLPE 1221
              P          E  P+S     + P    P+A R  P  +ES  +  P+E    P PE
Sbjct: 537  SPPPEASPLSPPFEESPLSPPPEEL-PTSPPPEASRLSPPPEESPMSPPPEESPMSPPPE 595

Query: 1222 ERK-----EEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETE----TKEPEVEE 1272
              +     EE  +    EE+      +A+    P   P DS  SP  E    +  PEV  
Sbjct: 596  ASRLFPPFEESPLSPPPEESPLSPPPEASRLSPP---PEDSPMSPPPEESPMSPPPEVSR 652

Query: 1273 EEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKEL 1332
                P VS   R S   ++    P PEE   +    A       +D              
Sbjct: 653  LSPLPVVS---RLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDS------------- 696

Query: 1333 EEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGS 1392
               P  ED    P  ++S +   +++S   +   EE +L    E P             S
Sbjct: 697  PTSPPPEDSPASPPPEDSLMSLPLEES-PLLPLPEEPQLCPRSEGPHL-----------S 744

Query: 1393 EDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEE---SSEHEGAY--QDCE 1447
                E     + E   L  + E PH  L  +  +       EE   S + EG +     E
Sbjct: 745  PRPEEPHLSPRPEEPHLSPQAEEPH--LSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPE 802

Query: 1448 ETLAACQTLQSYTQADEDPQMSMV--EDCHASE-HNSPISSVQSHPSQSVRSVSSPNVPA 1504
            E   + QT        E+P +S V  E C + +   S +S     P  S R   S   P 
Sbjct: 803  ELHLSPQT--------EEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPE 854

Query: 1505 LESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYE 1564
            LE       PE+           E  P+   P     S  + +   S+ G    +    E
Sbjct: 855  LEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEE 914

Query: 1565 NPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQ---- 1620
             P S             S + S S   +         S ++T       S    ++    
Sbjct: 915  LPLS------------PSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFG 962

Query: 1621 ----QSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQP-QPAP----Q 1671
                     P A   +++P    +  PP      P P PP    P P  P  PA     +
Sbjct: 963  AKGDSDPESPLAAPILETP----ISPPPEANCTDPEPVPPMILPPSPGSPVGPASPILME 1018

Query: 1672 PPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPE 1722
            P PPQ  P  Q    PQ     PP Q  PP    S+ +  +P   ++ + +
Sbjct: 1019 PLPPQCSPLLQHSLVPQN---SPPSQCSPPALPLSVPSPLSPIGKVVGVSD 1066



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 56/205 (27%), Positives = 71/205 (34%), Gaps = 42/205 (20%)

Query: 1634 SPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPPPP 1693
            +P++  VE        +P  PPP Q   P P   P    P     P  QP   P+  PPP
Sbjct: 2332 TPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPP 2391

Query: 1694 P------PPQQQP----------PLSQCSMNNSFTPAPMIMEI----PESGSTGNISIYE 1733
            P      PP+  P          P SQ S  +  TP P+  E     P +    +   Y 
Sbjct: 2392 PESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYS 2451

Query: 1734 RIPGDFGAGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSV---SLSNTG 1790
            R P        S+P +    A L          H  P    P V   A S+   SL   G
Sbjct: 2452 RPP--------SRPQSRDPFAPL----------HKPPRPQPPEVAFKAGSLAHTSLGAGG 2493

Query: 1791 LAQLAPSHPLAGTPQAQATMTPPPN 1815
                 P+ P AG   A+     PPN
Sbjct: 2494 FPAALPAGP-AGELHAKVPSGQPPN 2517



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 57/245 (23%), Positives = 93/245 (37%), Gaps = 30/245 (12%)

Query: 1644 PSNQQQQPPPPPPQQPQPPPPQPQPAPQPP------PPQQQPQQQPQPQ------PQQPP 1691
            P N++    PPP + P  PPP+  P   PP      PP ++    P P+      P +  
Sbjct: 433  PLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEES 492

Query: 1692 PPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFGAGSYSQPSATF 1751
            P  PP ++ PLS    ++ F+P       P   S  + ++   +     A   S P    
Sbjct: 493  PLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEES 552

Query: 1752 SLAKLQQLTNTIMDPHAM----PYSHSPAVTSYATSVSLSNTGLAQLAP---SHPLAGTP 1804
             L+   +   T   P A     P   SP       S        ++L P     PL+  P
Sbjct: 553  PLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPP 612

Query: 1805 QAQATMTPPPNLASTT-----MNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRS 1859
            + ++ ++PPP  +  +       ++ P  +  MS      P   RL   +PV   +S   
Sbjct: 613  E-ESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPP----PEVSRL-SPLPVVSRLSPPP 666

Query: 1860 KSAPL 1864
            + +PL
Sbjct: 667  EESPL 671



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 86/414 (20%), Positives = 138/414 (33%), Gaps = 30/414 (7%)

Query: 1581 SSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSM--MQQS----SVQPAANCSIKS 1634
            SS Q +    GL     +T       QQ    GS   +  +QQS    S QP  +     
Sbjct: 3836 SSPQLAQQGQGLMGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMG 3895

Query: 1635 PQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPPPPP 1694
                + ++    QQQQ      QQ Q      Q   Q    QQQ QQQ Q Q QQ     
Sbjct: 3896 SLQQLQQQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQL 3955

Query: 1695 PPQQQPPLSQCSMNNSFTPAPMIME-----IPESGSTGNISIYERIPGDFGAGSYSQPSA 1749
              QQQ    Q           ++ +      P+      +++   +P       +S P A
Sbjct: 3956 QQQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQVALGPGMPAK-PLQHFSSPGA 4014

Query: 1750 TFSLAKLQQLTNTIMDPHAM------PYSHSPAVTSYATSVSLSNTGLAQLAPSHPLAGT 1803
                  L       +DP         P +H     +  T+     T   ++ PS  L+G 
Sbjct: 4015 LGPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPGEVKPS--LSGD 4072

Query: 1804 PQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQ--RLQGQMPVKGHISIRSKS 1861
             Q    + P P    +++ L  PL         + + HT      GQ+         S++
Sbjct: 4073 SQL-LLVQPQPQPQPSSLQLQPPLRLPGQQQQQVSLLHTAGGGSHGQL----GSGSSSEA 4127

Query: 1862 APLPSAAAHQQQLYGRSPSAVAMQ-AGPRALAVQRGMNMGVNLMPTPAYNV--NSMNMNT 1918
            + +P   A      G  P ++     GP+   ++R M       P     V  +   +  
Sbjct: 4128 SSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPG 4187

Query: 1919 LNAMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNP 1972
            +  M +    +  +      NP   + + Q   Q+Q  +M  Q    Q ++  P
Sbjct: 4188 VGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTP 4241



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 19/55 (34%), Positives = 27/55 (49%)

Query: 1649 QQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLS 1703
            +Q   PPP++P PPP    P+P  PP +   +   +P  + P P P P    P S
Sbjct: 4904 RQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPES 4958



 Score = 40.4 bits (93), Expect = 0.018
 Identities = 20/69 (28%), Positives = 29/69 (42%), Gaps = 10/69 (14%)

Query: 1643 PPSNQQQQPPPPPPQQPQPPPPQP------QPAPQPPPPQQQP----QQQPQPQPQQPPP 1692
            PP  +   PP P    P  PP +P      +P  +PP P   P     +  +P+P+  PP
Sbjct: 4909 PPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPESARPKPRARPP 4968

Query: 1693 PPPPQQQPP 1701
                  +PP
Sbjct: 4969 EEGEDSRPP 4977



 Score = 40.0 bits (92), Expect = 0.023
 Identities = 21/67 (31%), Positives = 29/67 (43%), Gaps = 7/67 (10%)

Query: 260 IECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMW------ICQICRPR 313
           +E   C+ C   G+  D + FC SC   +H  C D  LT   +  W      +CQ CR  
Sbjct: 224 LEEARCAVCEGPGELCD-LFFCTSCGHHYHGACLDTALTARKRAGWQCPECKVCQACRKP 282

Query: 314 KKGRKLL 320
               K+L
Sbjct: 283 GNDSKML 289



 Score = 39.3 bits (90), Expect = 0.039
 Identities = 71/324 (21%), Positives = 107/324 (33%), Gaps = 39/324 (12%)

Query: 991  EEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFE 1050
            EE P SP     P    P   R  P           +    S   E         + P  
Sbjct: 550  EESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLS 609

Query: 1051 DSDSERPMP------RLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKS 1104
                E P+       RL P  E        +E+ + P     RLS   V+       R S
Sbjct: 610  PPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVV------SRLS 663

Query: 1105 KDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGK-SRKPIHW 1163
               EE   S   +++P   P    R   +   P +  TS P +     P  + S   +  
Sbjct: 664  PPPEESPLSPPPEESPTSPPPEASR---LSPPPEDSPTSPPPEDSPASPPPEDSLMSLPL 720

Query: 1164 KKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEER 1223
            ++ P            +P   Q C   P    P    +P+    E  + P+ + P    +
Sbjct: 721  EESPLLP---------LPEEPQLC---PRSEGPHLSPRPE----EPHLSPRPEEPHLSPQ 764

Query: 1224 KEEEEMQAEAEE----AEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRV 1279
             EE  +  + EE    A   E   +  +E P  SP         +T+EP +    E+P +
Sbjct: 765  AEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCL 824

Query: 1280 S---EEQRQSEEEQQELEEPEPEE 1300
            S   EE   S + ++    P PEE
Sbjct: 825  SPQPEESHLSPQSEEPCLSPRPEE 848



 Score = 35.8 bits (81), Expect = 0.43
 Identities = 37/131 (28%), Positives = 49/131 (37%), Gaps = 31/131 (23%)

Query: 1634 SPQSCVVERPPSNQQQQPPPPP-------PQQPQ--------PPPPQPQPAPQPPPPQQQ 1678
            SP    ++ PP    Q P   P       P +P+        PP P P  AP  PP    
Sbjct: 2155 SPGELFLKLPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGA 2214

Query: 1679 PQQQPQPQPQQ--PPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIP 1736
              +    QP +    PP  P+ QP           TP P +   P   S  N+++ E  P
Sbjct: 2215 SSRPGAGQPGEFHTTPPGTPRHQPS----------TPDPFLK--PRCPSLDNLAVPES-P 2261

Query: 1737 GDFGAGSYSQP 1747
            G  G G  S+P
Sbjct: 2262 G-VGGGKASEP 2271



 Score = 35.4 bits (80), Expect = 0.57
 Identities = 17/62 (27%), Positives = 26/62 (41%), Gaps = 6/62 (9%)

Query: 207 PICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCS 266
           P C  C   ++   + K   ++ C  C    H  CLK   E    + A  W+C  C+ C 
Sbjct: 271 PECKVCQACRKPGNDSK---MLVCETCDKGYHTFCLKPPME---ELPAHSWKCKACRVCR 324

Query: 267 SC 268
           +C
Sbjct: 325 AC 326



 Score = 34.7 bits (78), Expect = 0.96
 Identities = 20/60 (33%), Positives = 26/60 (43%), Gaps = 3/60 (5%)

Query: 209  CSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSC 268
            C  C+  +   +   P  L+ C DC  S H  CL   P LTV      W+C  C +C  C
Sbjct: 1424 CVECIVCEVCGQASDPSRLLLCDDCDISYHTYCLD-PPLLTVPKGG--WKCKWCVSCMQC 1480



 Score = 34.3 bits (77), Expect = 1.3
 Identities = 16/57 (28%), Positives = 25/57 (43%)

Query: 1665 QPQPAPQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIP 1721
            Q  PAP+PP              +Q   PPP +  PP S  + + +  P   ++E+P
Sbjct: 4881 QESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELP 4937



 Score = 33.1 bits (74), Expect = 2.8
 Identities = 86/390 (22%), Positives = 123/390 (31%), Gaps = 52/390 (13%)

Query: 924  EEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRRYS-EGDRAVLR 982
            EE P    +   P   L   + P       SP   +  L+   E LP     E  R    
Sbjct: 516  EESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRL--- 572

Query: 983  GFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETT 1042
                S   EE P SP     P+   P   R  P           +    S   E    + 
Sbjct: 573  ----SPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSP 628

Query: 1043 EVLDEPFEDSDSERPMP------RLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRC 1096
               D P      E PM       RL P   +       +E+ L P         +     
Sbjct: 629  PPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPP------EESPTSP 682

Query: 1097 QSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGK 1156
               + R S   E+   S   +D+P   P     +  + + PLE     PL ++      +
Sbjct: 683  PPEASRLSPPPEDSPTSPPPEDSPASPPP----EDSLMSLPLEESPLLPLPEEPQLCP-R 737

Query: 1157 SRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKED 1216
            S  P H   RP  +P      E           EP +S       P+ +E   + +P+E 
Sbjct: 738  SEGP-HLSPRP-EEPHLSPRPE-----------EPHLS-------PQAEEPHLSPQPEEP 777

Query: 1217 M--PLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADS----SNSPETETKEPEV 1270
                +PEE     + +      +  E   +  +E P  SP       S  PE     P+ 
Sbjct: 778  CLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQS 837

Query: 1271 EEEEEKPRVSEEQRQSEEEQQELEEPEPEE 1300
            EE    PR  E     E E+  L  P PE+
Sbjct: 838  EEPCLSPRPEESHLSPELEKPPL-SPRPEK 866



 Score = 31.6 bits (70), Expect = 8.2
 Identities = 26/93 (27%), Positives = 31/93 (33%), Gaps = 16/93 (17%)

Query: 1647 QQQQPPPPPPQQP------------QPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPPPPP 1694
            +Q+ P P PP Q             Q   P P+    PP P       P  +P    P  
Sbjct: 4880 KQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTE 4939

Query: 1695 PPQQQP---PLSQCSMNNSFTPAPMIMEIPESG 1724
            P  + P   PL   S   S  P P     PE G
Sbjct: 4940 PLAEPPVPSPLPLASSPESARPKPRARP-PEEG 4971


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 91/336 (27%), Positives = 145/336 (43%), Gaps = 25/336 (7%)

Query: 1205 QESEETVEPK-EDMPLPEERKEEEEMQAEAEEAE--EGEEEDAASSEVPAASPADSSNSP 1261
            QE+E   +P+ ED+  PE    E E Q E+E+ E  E E E    SE   A  A+    P
Sbjct: 1861 QEAEGEAQPESEDVEAPEA---EGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQP 1917

Query: 1262 ETETKEP-EVEEEEEKPRVSEEQRQSEEEQQELE-EPEPEEEEDAAAETAQNDDHDADDE 1319
            ETE+ E  E E E+E      E +++EE  QE E + +PE E   + E  +    +++D 
Sbjct: 1918 ETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDV 1977

Query: 1320 DDGHLE-STKKKELEEQPTREDV---KEEPGVQESFLDANMQKSREKIKDKEETELDSEE 1375
            +   +E  T++ E E QP  EDV   + E  +QE+  +A  +    + + K E E   E 
Sbjct: 1978 EALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEV 2037

Query: 1376 EQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEE 1435
            E  +  T   ++  +   +  E +   +E   E++E E   H E +    Q  +   Q E
Sbjct: 2038 EGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPE 2097

Query: 1436 SS-----EHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPIS-SVQSH 1489
            S      E EG  Q  E   A        T+ +  P+   +E   A     P S  V++ 
Sbjct: 2098 SEGVEAPEAEGEAQKAEGIEA------PETEGEAQPESEGIEAPEAEGEAQPESEGVEAQ 2151

Query: 1490 PSQSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQ 1525
             ++      S  + A E+   +  PE   + AP  +
Sbjct: 2152 DAEGEAQPESEGIEAQEA-EEEAQPELEGVEAPEAE 2186



 Score = 81.3 bits (199), Expect = 9e-15
 Identities = 79/347 (22%), Positives = 145/347 (41%), Gaps = 33/347 (9%)

Query: 1206 ESEETVEPK-EDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETE 1264
            E+E   +P+ ED+  PE    E E+Q E+E AE  E E  A  E  +    ++    E E
Sbjct: 1878 EAEGEAQPESEDVETPEA---EWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPE 1934

Query: 1265 TKEPEVEEEEEKPRVSEEQRQSEE---EQQELEEPEPEEEEDAAAETAQNDDHDADDEDD 1321
            ++  E +E EE  + +E Q Q E    E QE EE    E ED  A   + +  +A+ E  
Sbjct: 1935 SEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQ 1994

Query: 1322 GHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKE-ETELDSEEEQPSH 1380
               E  +  E E +   ++ +EE   +   ++A  +   E+ ++ E ET+    + QP  
Sbjct: 1995 PESEDVEAPEAEGE--MQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES 2052

Query: 1381 D------TSVVSEQMAGSEDDHEEDSHTKEELIELKEEE----------EIPHSELDLET 1424
            D          +++  G   + E ++H + E ++ +E E          E P +E + + 
Sbjct: 2053 DGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQK 2112

Query: 1425 VQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADE-----DPQMSMVEDCHASEH 1479
             + +++   E  ++ E    +  E     Q      +A +      P+   +E   A E 
Sbjct: 2113 AEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEE 2172

Query: 1480 NSP-ISSVQSHPSQSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQ 1525
              P +  V++  ++      S  + A E+   +  PE   + AP  +
Sbjct: 2173 AQPELEGVEAPEAEGEAQPESEGIEAPEA-EGEAQPELEGVEAPEAE 2218



 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 100/497 (20%), Positives = 180/497 (36%), Gaps = 61/497 (12%)

Query: 1225 EEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQR 1284
            E  E + EA+   EG E   A  +   A       S + E  E E E + E   V   + 
Sbjct: 1836 EAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEA 1895

Query: 1285 QSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEE 1344
            + E + +      PE E++A  ET   +  + + ED+   E  + +E EE     + + +
Sbjct: 1896 EWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQ 1955

Query: 1345 PGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKE 1404
            P       ++ + +S+E    +EE + +SE+ + + +  V +++  G      ED    E
Sbjct: 1956 P-------ESEVIESQEA---EEEAQPESEDVE-ALEVEVETQEAEGEAQPESEDVEAPE 2004

Query: 1405 ELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADE 1464
               E++E EE    E D   V+A      EE+ E EG  Q               T+ D 
Sbjct: 2005 AEGEMQEAEEEAQPESD--GVEAQPKSEGEEAQEVEGETQK--------------TEGDA 2048

Query: 1465 DPQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSPNVPALESGYTQISPEQGSLSAPSM 1524
             P+   VE   A E        +   ++      S +V A E+   +  PE   + AP  
Sbjct: 2049 QPESDGVEAPEAEEEAQEAEG-EVQEAEGEAHPESEDVDAQEA-EGEAQPESEGVEAPEA 2106

Query: 1525 Q-NMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNSSS 1583
            +   + +  ++ P     +Q        +   IE+     E     +        G +  
Sbjct: 2107 EGEAQKAEGIEAPETEGEAQ-------PESEGIEAPEAEGEAQPESEGVEAQDAEGEAQP 2159

Query: 1584 QSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERP 1643
            +S     G+ +  +  ++   +    A      +  +   ++         P+   VE P
Sbjct: 2160 ESE----GIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAP 2215

Query: 1644 PSNQQQQPPPPPPQQP------QPPPPQPQPAPQPPPPQ--------QQPQQQPQPQPQQ 1689
             + ++ QP P   + P      QP         +   PQ        ++  +   P P+ 
Sbjct: 2216 EAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPED 2275

Query: 1690 PPPPPP------PQQQP 1700
             P PPP      P Q+P
Sbjct: 2276 RPTPPPSPGGDTPHQRP 2292



 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 99/408 (24%), Positives = 165/408 (40%), Gaps = 40/408 (9%)

Query: 1206 ESEETVEPKEDMPLPEERKEEEEMQ---AEAEEAEEGEEE----DAASSEVPAASPADSS 1258
            E+E+  +P+ +     E + E+E +   AEA+EAEE  +E        SEV  +  A+  
Sbjct: 1910 EAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEE 1969

Query: 1259 NSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADD 1318
              PE+E    +VE  E +    E + +++ E +++E PE E E   A E AQ +    + 
Sbjct: 1970 AQPESE----DVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEA 2025

Query: 1319 EDDGHLESTKKKELEEQPTREDVK-EEPGVQESFLDANMQKSREKIKDKE-ETELDSEEE 1376
            +     E  ++ E E Q T  D + E  GV+    +   Q++  ++++ E E   +SE+ 
Sbjct: 2026 QPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDV 2085

Query: 1377 QPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEE--EEIPHSELDLETVQAVQSLTQE 1434
                       +  G E    E    K E IE  E   E  P SE  +E  +A      E
Sbjct: 2086 DAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESE-GIEAPEAEGEAQPE 2144

Query: 1435 ----ESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHP 1490
                E+ + EG  Q   E + A +      + +  P++  VE   A     P S     P
Sbjct: 2145 SEGVEAQDAEGEAQPESEGIEAQE-----AEEEAQPELEGVEAPEAEGEAQPESEGIEAP 2199

Query: 1491 SQSVRSVSSPNVPALES--GYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHS---QQV 1545
                   + P +  +E+     +  PE   +  P  +  E  P  +  +  +     Q  
Sbjct: 2200 --EAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEG-EAQPESEGETQGEKKGSPQVS 2256

Query: 1546 VDSGFSDLGSIESTTENYENPSSYDSTMG-------GSICGNSSSQSS 1586
            +  G S+  S  S+    + P+   S  G       GS  G SSS++S
Sbjct: 2257 LGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRAS 2304



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 105/484 (21%), Positives = 173/484 (35%), Gaps = 47/484 (9%)

Query: 1221 EERKEEEEMQA-EAE-EAEEGEEEDAASSEVPAASPADSSNSPETETKEP-----EVEEE 1273
            E + E E ++A EAE +A+E E E    SE   A  A+    PE+E  E      EV+ E
Sbjct: 1843 EAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPE 1902

Query: 1274 EEKPRVSEEQRQSEEEQQELEEPEPE-----EEEDAAAETAQNDDHDADDEDDGHLESTK 1328
             E     E +++++ E + +E  E E     E E A A+ A+    +A+ +     E  +
Sbjct: 1903 SEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIE 1962

Query: 1329 KKELEE--QPTREDVKE-EPGVQESFLDANMQKSREKIKDKE---ETELDSEEEQPSHDT 1382
             +E EE  QP  EDV+  E  V+    +   Q   E ++  E   E +   EE QP  D 
Sbjct: 1963 SQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDG 2022

Query: 1383 SVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEH-EG 1441
                 +  G E    E    K E     E + +   E + E  +A   + + E   H E 
Sbjct: 2023 VEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPES 2082

Query: 1442 AYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSPN 1501
               D +E            + +  P+   VE   A         +++  ++      S  
Sbjct: 2083 EDVDAQE-----------AEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEG 2131

Query: 1502 VPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTE 1561
            + A E+   +  PE   + A   +  E  P     S    +Q+  +    +L  +E+   
Sbjct: 2132 IEAPEA-EGEAQPESEGVEAQDAEG-EAQP----ESEGIEAQEAEEEAQPELEGVEAPEA 2185

Query: 1562 NYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQQ 1621
              E     +        G +  +        +   +  +   V T +           Q 
Sbjct: 2186 EGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEA------QP 2239

Query: 1622 SSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQQ 1681
             S          SPQ  + +       +   P P  +P PP     P+P    P Q+P  
Sbjct: 2240 ESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPP-----PSPGGDTPHQRPGS 2294

Query: 1682 QPQP 1685
            Q  P
Sbjct: 2295 QTGP 2298



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 111/457 (24%), Positives = 173/457 (37%), Gaps = 49/457 (10%)

Query: 1190 EPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEE---GEEEDAAS 1246
            E + ++   G      E  E  E +E     E + + E    E++EAEE    E ED  +
Sbjct: 1920 ESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEA 1979

Query: 1247 SEVPA-ASPADSSNSPETETKE-PEVE------EEEEKPR---VSEEQRQSEEEQQELEE 1295
             EV      A+    PE+E  E PE E      EEE +P    V  + +   EE QE+E 
Sbjct: 1980 LEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEG 2039

Query: 1296 PEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDV----------KEEP 1345
               + E DA  E+   +  +A++E        ++ E E  P  EDV           E  
Sbjct: 2040 ETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESE 2099

Query: 1346 GVQESFLDANMQKSR--EKIKDKEETELDSEE-EQPSHDTSVVSEQMAGSEDDHEEDSHT 1402
            GV+    +   QK+   E  + + E + +SE  E P  +     E       D E ++  
Sbjct: 2100 GVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQP 2159

Query: 1403 KEELIELKEEEEIPHSELDLETVQAVQSLTQEESS--EHEGAYQDCEETLAACQTLQSYT 1460
            + E IE +E EE    EL+       +   Q ES   E   A  + +  L   +  ++  
Sbjct: 2160 ESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEE 2219

Query: 1461 QADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSPNVPALESGYTQISPEQGSLS 1520
            +A  +P+   VE   A     P S  ++   +      SP V +L  G ++ + E  S  
Sbjct: 2220 EAQPEPE--GVETPEAEGEAQPESEGETQGEKK----GSPQV-SLGDGQSEEASESSSPV 2272

Query: 1521 APSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGN 1580
                     SP  D P     SQ          G   S   ++ N    DS     + G+
Sbjct: 2273 PEDRPTPPPSPGGDTPHQRPGSQ---------TGPSSSRASSWGNCWQKDSE-NDHVLGD 2322

Query: 1581 SSSQSSCSYGGLSSSSSLTQ---SSCVVTQQMASMGS 1614
            + S  + S G   +    T+    S    Q+ A +GS
Sbjct: 2323 TRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGS 2359



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 61/234 (26%), Positives = 91/234 (38%), Gaps = 22/234 (9%)

Query: 1205 QESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGE--EEDAASSEVPAASPADSSNSPE 1262
            ++SEE         L E   +EE    E +E  EGE  +E+A   E             E
Sbjct: 1278 RDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLE-------------E 1324

Query: 1263 TETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDG 1322
            T+T+E   EE  +     EE +++E E Q+ EE + EE E+   E  Q +    ++  +G
Sbjct: 1325 TKTEEGLQEEGVQ----LEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEG 1380

Query: 1323 HLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDT 1382
                 + + LEE    E + EE  V    L    + S    K  +E +   EEE      
Sbjct: 1381 PEGGLQGEALEEGLKEEGLPEEGSVHGQELS---EASSPDGKGSQEDDPVQEEEAGRASA 1437

Query: 1383 SVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEES 1436
            S       G+E+  E  SH  E      E +     E  LE       + QE +
Sbjct: 1438 SAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHT 1491



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 218/1138 (19%), Positives = 389/1138 (34%), Gaps = 168/1138 (14%)

Query: 787  SEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRL 846
            + E+E E +  E       E+  E +V + V  E  ++ +   E E   E    +  T+ 
Sbjct: 1271 TNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGT---EGEGLQEEAVQLEETK- 1326

Query: 847  SKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG-ECGEK 905
            +++ L  + +         G   ++     E   +   + L EE     + + G E G +
Sbjct: 1327 TEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQ 1386

Query: 906  SEATQEQYTES---EEQLVASEE---QPSQDGK---PDLPKR-----RLSEGVEPWRGQL 951
             EA +E   E    EE  V  +E     S DGK    D P +     R S   EP   + 
Sbjct: 1387 GEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEG 1446

Query: 952  KKSPEALKCRLTEGSERLPRRYSEGDR---------AVLRGFSESSEEEEEPESPRSSS- 1001
             + P      L+E       R S             A + G   +  +  +  + RSSS 
Sbjct: 1447 TEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSV 1506

Query: 1002 --------PPILTKPTLKR-KKPFL-HRRRRVRKRKHH----NSSVVTETISETTEVLDE 1047
                     PI     LK+ +K FL H    V + +      ++ ++ +  +E  + + +
Sbjct: 1507 ACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQ 1566

Query: 1048 PFEDSDSERPMPRLEPTFE--IDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKS- 1104
              +DS ++R + +L+      + E   E    EL  +   RR   + +    + S+R   
Sbjct: 1567 RLQDS-TKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLG 1625

Query: 1105 --------KDEEE------DEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKK 1150
                    +DE         +  ++A+        + +RK   K SP+ P      K   
Sbjct: 1626 LGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRK---KVSPMSP------KATM 1676

Query: 1151 GWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPI----VSIPKAGRKPKIQE 1206
            G  +G  ++    ++   RK G     E   V+      +P     V   + G  P + +
Sbjct: 1677 GATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQ 1736

Query: 1207 SEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETK 1266
                 E ++        ++++    EAE     +E +              +++ ET   
Sbjct: 1737 GPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREG------------KTHNSETSAG 1784

Query: 1267 EPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLES 1326
                E E+E   +S        E+ E        E++   E A   D D    D      
Sbjct: 1785 SELGEAEQEGEGIS--------ERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIE 1836

Query: 1327 TKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVS 1386
              + E E QP  E V E P  +    +A  +   E  +D E  E + E +  S D     
Sbjct: 1837 APEAEGEAQPESEGV-EAPEAEGDAQEAEGEAQPES-EDVEAPEAEGEAQPESEDV---- 1890

Query: 1387 EQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLE-TVQAVQSLTQEESSEHEGAYQD 1445
                       E    + E+    E  E P +E + +   ++V++L  E   E E    +
Sbjct: 1891 -----------ETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAE 1939

Query: 1446 CEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPIS--------SVQSHPSQSVRSV 1497
             +E   A Q  +  TQ    P+  ++E   A E   P S         V++  ++     
Sbjct: 1940 AQEAEEAAQEAEGQTQ----PESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQP 1995

Query: 1498 SSPNVPALES-GYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSI 1556
             S +V A E+ G  Q + E+   + P    +E  P     S  + +Q+V        G  
Sbjct: 1996 ESEDVEAPEAEGEMQEAEEE---AQPESDGVEAQP----KSEGEEAQEVEGETQKTEGDA 2048

Query: 1557 ESTTENYENPSSYDSTMGG-----SICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMAS 1611
            +  ++  E P + +             G +  +S       +   +  +S  V   +   
Sbjct: 2049 QPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEG 2108

Query: 1612 MGSSCSMMQ----QSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQ 1667
                   ++    +   QP +   I++P++    +P S   +        QP+    + Q
Sbjct: 2109 EAQKAEGIEAPETEGEAQPESE-GIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQ 2167

Query: 1668 PAPQPPPPQQQPQQQPQPQPQQPP-------PPPPPQQQPPLSQC---SMNNSFTPAPMI 1717
             A +   P+ +  + P+ + +  P       P    + QP L             P P  
Sbjct: 2168 EAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEG 2227

Query: 1718 MEIPESGSTGNISIYERIPGD--------FGAGSYSQPSATFSLAKLQQLTNTIM----D 1765
            +E PE+             G+         G G   + S + S     + T         
Sbjct: 2228 VETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDT 2287

Query: 1766 PHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPLAGT--PQAQATMTPPPNLASTTM 1821
            PH  P S +   +S A+  S  N         H L  T  P A++T TP     +T M
Sbjct: 2288 PHQRPGSQTGPSSSRAS--SWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRM 2343



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 118/588 (20%), Positives = 199/588 (33%), Gaps = 85/588 (14%)

Query: 782  SNSVVSEEEEEEAEEGENE-EPQCQERELEISVGKSVSHENKEQDSYSVESEKKPE---V 837
            S  V + E E +A+E E E +P+ ++ E   + G++   E+++ ++   E E +PE    
Sbjct: 1848 SEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEA-QPESEDVETPEAEWEVQPESEGA 1906

Query: 838  MAPVSSTRLSKQVLPHDSLPANSQ--PSRRGRWGRKNRKT-QERFGDKDSKLLLEETSSA 894
             AP +      +    ++L    +  P   G   ++  +  QE  G    +  + E+  A
Sbjct: 1907 EAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEA 1966

Query: 895  P-------------------QEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDL 935
                                QE  GE   +SE  +    E E Q    E QP  DG    
Sbjct: 1967 EEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQ 2026

Query: 936  PKRRLSEGVEPWRGQLKKS-----PEALKCRLTEGSERLPRRYSEGDRAVLRGFSES--- 987
            PK    E  E   G+ +K+     PE+      E  E       E   A      ES   
Sbjct: 2027 PKSEGEEAQEV-EGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDV 2085

Query: 988  ----SEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTE 1043
                +E E +PES    +P    +    +K   +       + +  +  +         +
Sbjct: 2086 DAQEAEGEAQPESEGVEAPEAEGEA---QKAEGIEAPETEGEAQPESEGIEAPEAEGEAQ 2142

Query: 1044 VLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRK 1103
               E  E  D+E      +P  E  E +E E+E +         L   +    +  ++ +
Sbjct: 2143 PESEGVEAQDAEG---EAQPESEGIEAQEAEEEAQ-------PELEGVEAPEAEGEAQPE 2192

Query: 1104 SKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHW 1163
            S+  E  E   +A   P L+ V      + +  P      TP  + +  P+ +       
Sbjct: 2193 SEGIEAPEAEGEAQ--PELEGVEAPEAEE-EAQPEPEGVETPEAEGEAQPESEGETQGEK 2249

Query: 1164 KKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEER 1223
            K  P    G   S E    S+                   + E   T  P      P +R
Sbjct: 2250 KGSPQVSLGDGQSEEASESSSP------------------VPEDRPTPPPSPGGDTPHQR 2291

Query: 1224 KEEEEMQAEAEEAEEGE--EEDAASSEV--PAASP-ADSSNSPETETK------EPEVEE 1272
               +   + +  +  G   ++D+ +  V     SP A S+ +P  E K      E    E
Sbjct: 2292 PGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSE 2351

Query: 1273 EEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDED 1320
            +EE P  S    Q   E  +L+E +            + D    DD D
Sbjct: 2352 QEEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAVGRADGFGQDDLD 2399



 Score = 40.4 bits (93), Expect = 0.018
 Identities = 65/310 (20%), Positives = 115/310 (37%), Gaps = 36/310 (11%)

Query: 1216 DMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEE 1275
            ++PL    +  +    E+    E +++    + + A + A ++N  E E      + EE+
Sbjct: 1229 ELPLKTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAER-----DSEEQ 1283

Query: 1276 KPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKE--LE 1333
            +   + EQ      Q+E++            ET +  + +   E+   LE TK +E   E
Sbjct: 1284 RASSNLEQLAENTVQEEVQ----------LEETKEGTEGEGLQEEAVQLEETKTEEGLQE 1333

Query: 1334 EQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSE 1393
            E    E+ KE  G          Q+   ++++ EET  +  +E+      V      G +
Sbjct: 1334 EGVQLEETKETEG-------EGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQ 1386

Query: 1394 DDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETLAAC 1453
             +  E+   KEE   L EE  +   EL      +  S    + S+ +   Q+ E   A+ 
Sbjct: 1387 GEALEEG-LKEE--GLPEEGSVHGQEL------SEASSPDGKGSQEDDPVQEEEAGRASA 1437

Query: 1454 QTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSPNVPALESGYTQIS 1513
                   +  E+P        H SE +   S  QS           P    +   +TQ  
Sbjct: 1438 SAEPCPAEGTEEP---TEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQ 1494

Query: 1514 PEQGSLSAPS 1523
            P QG+    S
Sbjct: 1495 PTQGAAERSS 1504


>gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapiens]
          Length = 1341

 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 175/793 (22%), Positives = 288/793 (36%), Gaps = 73/793 (9%)

Query: 1057 PMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDA 1116
            P    +P  +I EE  +      F ++Y  +       R +  ++  ++ EE   ES+D 
Sbjct: 117  PHAAFQPNSQIGEEMSQNS----FIKQYLEKQQELLRQRLEREAREAAELEEASAESEDE 172

Query: 1117 DDTP-----ILKP--VSLLRKRDVKNSPLEPDTSTPLKKKKGWPKG-KSRKPIHWKKRPG 1168
               P     +L P   S L + +++ S   P  S+ + ++KG     K RK      R  
Sbjct: 173  MIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVR 232

Query: 1169 RKPGFKLSREIMPVSTQACVIEPIVSIP-KAGRKPKIQESEETVEPKEDMPLPEERKEEE 1227
            +    KLS    P   +     P  ++  +A R  K +E EE  E +E+    EE  +E 
Sbjct: 233  QARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEG 292

Query: 1228 EMQAEAEEAEEGEEEDAASSEVPAASPADSSNS-PETETKEPEVEEEEEK-PRVSEEQRQ 1285
            +   EA   +E +EE     E+P   P +  +  P+T ++E EV E   +  R  EE R+
Sbjct: 293  QKSREAPILKEFKEE---GEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARK 349

Query: 1286 S----EEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHL-ESTKKKELEEQPTRED 1340
            S    +++++E++   P EEE+   +++Q     +       L E  KK  L   P +  
Sbjct: 350  SHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTA 409

Query: 1341 VKEEPGVQESFLDANMQKSREKIKDKEETE----------LDSEEEQPSHDTS--VVSE- 1387
             +EE        +A+      ++  +EE E          +         DT   +VS+ 
Sbjct: 410  SEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQH 469

Query: 1388 --QMAGSEDDHEEDSHTKEE--LIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAY 1443
              Q+ G        S TK E    ++ EE  +P  +       + Q   + ES       
Sbjct: 470  TVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPL 529

Query: 1444 QDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSV-QSHPSQSVRSVSSPNV 1502
                E LA  + +    +  + P +   E   AS    P   + QS  S S RS SS + 
Sbjct: 530  PLKIEELALAKGITE--ECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSS 587

Query: 1503 PALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTEN 1562
             +     +  S   GS S   ++    S   DV     H+            + ES + +
Sbjct: 588  SSRSRSRSPDS--SGSRSHSPLR----SKQRDVAQARTHANPRGRPKMGSRSTSESRSRS 641

Query: 1563 YENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQQS 1622
                 S  S    S+    S  SS SY      SS  + +     Q+      C   +++
Sbjct: 642  RSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQL----QVCEPKERT 697

Query: 1623 SVQPAANCSIKSPQSCVVERPPS-----NQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQ 1677
            S       S  S Q+  + +P S      Q+ QP    P++ +    +P  A QP   + 
Sbjct: 698  ST------SSSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSET 751

Query: 1678 QPQQQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIM-------EIPESGSTGNIS 1730
            Q    P+ +          +     S+    N     PM +       + PE        
Sbjct: 752  QTSHLPESERIHHTVEEKEEVTMDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDEEK 811

Query: 1731 IYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTG 1790
                +P  F     S  SAT  +      T          +  S A T    S+S++   
Sbjct: 812  KESSLPKSF-KRKISVVSATKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTES 870

Query: 1791 LAQLAPS-HPLAG 1802
            L  L P   PLAG
Sbjct: 871  LKSLIPDIKPLAG 883



 Score = 68.2 bits (165), Expect = 8e-11
 Identities = 141/639 (22%), Positives = 224/639 (35%), Gaps = 143/639 (22%)

Query: 1194 SIPKAGRKPKIQESEETVEPKEDMPLPEERKE--EEEMQAEAEEAEEGEEEDAASSE--- 1248
            S P A  +P  Q  EE  +        E+++E   + ++ EA EA E EE  A S +   
Sbjct: 115  STPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMI 174

Query: 1249 ----VPAASPADSSNSPETETKEPEVEEEEEKPR----VSEEQRQSEEEQQELEEPEPEE 1300
                V +  P D  +S E     PE+E     PR    +SEE+  S++E+    E     
Sbjct: 175  HPEGVASLLPPDFQSSLE----RPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSR 230

Query: 1301 EEDAAAETAQNDDHDADDEDDGHLES------------TKKKELEEQPTREDVKEEPGVQ 1348
               A A         A++E+D    S            T+++E EE+   ED +EE G  
Sbjct: 231  VRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDD 290

Query: 1349 ESFLDANMQKSREKIKDKEETELDSE----------EEQPSHDTSVVSEQMAGSEDDHEE 1398
            E       QKSRE    KE  E   E          +E+P   +        G      +
Sbjct: 291  EG------QKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQ 344

Query: 1399 DSHTKEELIELKEEEEIPHS---ELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQT 1455
            +   K  L   ++E+E+  +   E +   +++ Q L ++  S       + +   A+   
Sbjct: 345  EEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTE-DRKKASLVA 403

Query: 1456 LQSYTQADED----------------PQMSMVEDCHASEHNSPISSVQSHPSQS------ 1493
            L   T ++E+                PQ+   E+    E  +P   +Q  P  +      
Sbjct: 404  LPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTRE 463

Query: 1494 -------------VRSVSSPNVPALESGYTQISPEQGSLSAPSMQNM-ETSPMMDVPSVS 1539
                         +  +SSP+    ES   ++ PE+  L       + + S   D+   S
Sbjct: 464  LLVSQHTVQLVGGLSPLSSPSDTKAESPAEKV-PEESVLPLVQKSTLADYSAQKDLEPES 522

Query: 1540 DHSQQVVDSGFSDLGSIESTTEN-YENPS---------------------SYDSTMGGSI 1577
            D S Q +     +L   +  TE   + PS                     S DS+   S 
Sbjct: 523  DRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSS 582

Query: 1578 CGNSSSQSSCS----YGGLSSSSSLTQSSCVVTQ-----------QMASMGSSCSMMQQS 1622
              +SSS  S S      G  S S L      V Q           +M S  +S S  +  
Sbjct: 583  SSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSR 642

Query: 1623 SVQPAANCSIKSPQSCVVER----------PPSNQQQQPPPPPPQQPQPPPP-------- 1664
            S   +A+ + +   S  V R           PS+ Q+   PP PQ     P         
Sbjct: 643  SRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSS 702

Query: 1665 --QPQPAPQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPP 1701
              Q +   QP   ++   Q+ QP+   P      + +PP
Sbjct: 703  SVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPP 741



 Score = 68.2 bits (165), Expect = 8e-11
 Identities = 156/714 (21%), Positives = 257/714 (35%), Gaps = 85/714 (11%)

Query: 783  NSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVS 842
            N    EEEEEE EE E++E +  + E + S    +  E KE+    +   K  E+M    
Sbjct: 266  NLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGE-EIPRVKPEEMMDERP 324

Query: 843  STRLSKQ-VLPHDSLPANSQ-PSRRGRWGR----KNRKT-----QERFGDKDSKLLLEET 891
             TR  +Q VL        SQ  +R+    R    K  KT     +E    K S+ L E++
Sbjct: 325  KTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKS 384

Query: 892  SSAPQEQYGECGEKSE--ATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRG 949
             S    +  E  +K+   A  EQ T SEE+             P  P+    E +EP  G
Sbjct: 385  KSPSPPRLTEDRKKASLVALPEQ-TASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEG 443

Query: 950  QLKKSPEALKCRLTEGSER--LPRRYS---EGDRAVLRGFSESSEEEEEPESPRSSSPPI 1004
                    L    T+   R  L  +++    G  + L   S++  E    + P  S  P+
Sbjct: 444  PAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPL 503

Query: 1005 LTKPTL------KRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPM 1058
            + K TL      K  +P   R  +    K    ++       T E L +P          
Sbjct: 504  VQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAK---GITEECLKQP---------- 550

Query: 1059 PRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADD 1118
                    ++++E     + L P    ++ +     R  SSS   S+      +S  +  
Sbjct: 551  -------SLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRS 603

Query: 1119 TPILKPVSLLRKRDV---------KNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKK-RPG 1168
               L+     ++RDV         +  P     ST   + +   + +S      K   PG
Sbjct: 604  HSPLRS----KQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPG 659

Query: 1169 --RKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKE-DMPLPEERKE 1225
              R      +    P S Q     P+  +     K +   S  +V+ +    P   E+  
Sbjct: 660  VSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHV 719

Query: 1226 EEEMQAEAEEAE--EGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQ 1283
             + +Q E    +  E EE +  ++  P  S   +S+ PE+E     VEE+EE    + E 
Sbjct: 720  TQRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSEN 779

Query: 1284 RQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKE 1343
            R         E   PE     A + + +D  +   ED+   ES+  K  + + +   V  
Sbjct: 780  RP--------ENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKIS--VVSA 829

Query: 1344 EPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVS------EQMAGSE---D 1394
              GV     D    +   K +    T    ++   S  T  +       + +AG E   D
Sbjct: 830  TKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVD 889

Query: 1395 DHEEDSHTKEELIELKEEEEIPHSELDL-ETVQAVQSLTQEESSEHEGAYQDCE 1447
             H +DS   E+  E   ++      L +  TV  V     +E+ + E   ++ E
Sbjct: 890  LHADDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKE 943



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 113/598 (18%), Positives = 211/598 (35%), Gaps = 89/598 (14%)

Query: 788  EEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLS 847
            EE+EE   +     P+    E  + +   VS++++ + S  VE E+K E   P S  R  
Sbjct: 767  EEKEEVTMDTSENRPENDVPEPPMPIADQVSNDDRPEGS--VEDEEKKESSLPKSFKRKI 824

Query: 848  KQVLPHDSLPANS------QPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGE 901
              V     +PA +      QP R+ RWG     TQ++       +  E   S   +    
Sbjct: 825  SVVSATKGVPAGNSDTEGGQPGRKRRWGASTATTQKK---PSISITTESLKSLIPDIKPL 881

Query: 902  CGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCR 961
             G+  EA  + + +         E+   DG  D       +G++  R   +  P      
Sbjct: 882  AGQ--EAVVDLHADDSRISEDETERNGDDGTHD-------KGLKICRTVTQVVP------ 926

Query: 962  LTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRR 1021
              EG E               G  E  EEE+EPE+     P +  +  L    P  H  +
Sbjct: 927  -AEGQEN--------------GQREEEEEEKEPEAEPPVPPQVSVEVALP--PPAEHEVK 969

Query: 1022 RVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERP----------MPRLEPTFEIDEEE 1071
            +V          +++  S  +  +D+P   +    P          +  L   F + + +
Sbjct: 970  KVTLGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVRPFTLGQLK 1029

Query: 1072 EEEDENELFPREYF---------------------RRLSSQDVLRCQSSSKRKSKDEEED 1110
            E          E F                      R +   V   QS+ K    D  E 
Sbjct: 1030 ELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQ 1089

Query: 1111 EESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRK 1170
            +E D      + +P     +      PL P    P++  +  P+ + R+     +    +
Sbjct: 1090 DELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQH-PRAEQREQERAVREQWAE 1148

Query: 1171 PGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQ 1230
               ++ R     S +    + +   P++  + + +  +E  + KE      E+KE+ + +
Sbjct: 1149 REREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKK---SEKKEKAQEE 1205

Query: 1231 AEAEEAEEGEEEDAAS----------SEVPAASPADSSNSPETETKEPEVEEEEEKPRVS 1280
              A+  ++   +  A+          S++       +  + E E +  E EEEE+K R  
Sbjct: 1206 PPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREK 1265

Query: 1281 EEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTR 1338
            E +R+   + +  +  E   E D   E  +  D   D + D   +  + +E + + T+
Sbjct: 1266 EAERERNRQLEREKRREHSRERDRERERERERDR-GDRDRDRERDRERGRERDRRDTK 1322



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 113/522 (21%), Positives = 176/522 (33%), Gaps = 100/522 (19%)

Query: 781  VSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAP 840
            ++   + +   E+ E             L+ S   S S  +    S S    + P+    
Sbjct: 542  ITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGS 601

Query: 841  VSSTRL-SKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQY 899
             S + L SKQ    D   A +  + RGR    +R T E      S+     ++S      
Sbjct: 602  RSHSPLRSKQ---RDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSP 658

Query: 900  GECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALK 959
            G   + S +  E    S  Q VA+   P        PK R S      + +    PE+ +
Sbjct: 659  GVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCE--PKERTSTSSSSVQARRLSQPESAE 716

Query: 960  CRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKP-TLKRKKPFLH 1018
              +T+      R   E      RG  +  E EE       + PP  T+P T + +   L 
Sbjct: 717  KHVTQ------RLQPE------RGSPKKCEAEE-------AEPPAATQPQTSETQTSHLP 757

Query: 1019 RRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENE 1078
               R+    HH      E   +T+E  + P E+   E PMP       I ++   +D  E
Sbjct: 758  ESERI----HHTVEEKEEVTMDTSE--NRP-ENDVPEPPMP-------IADQVSNDDRPE 803

Query: 1079 LFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPL 1138
                                     S ++EE +ES          P S  RK  V ++  
Sbjct: 804  ------------------------GSVEDEEKKESS--------LPKSFKRKISVVSAT- 830

Query: 1139 EPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKA 1198
                       KG P G S          G +PG K        +TQ    +P +SI   
Sbjct: 831  -----------KGVPAGNS-------DTEGGQPGRKRRWGASTATTQK---KPSISITTE 869

Query: 1199 GRKPKIQESEETV--EPKEDMPLPEERKEEEEMQAEAEEAEEGEEED---AASSEVPAAS 1253
              K  I + +     E   D+   + R  E+E +   ++    +        +  VPA  
Sbjct: 870  SLKSLIPDIKPLAGQEAVVDLHADDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEG 929

Query: 1254 PADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEE 1295
              +     E E KEPE  E    P+VS E       + E+++
Sbjct: 930  QENGQREEEEEEKEPEA-EPPVPPQVSVEVALPPPAEHEVKK 970



 Score = 39.7 bits (91), Expect = 0.030
 Identities = 118/628 (18%), Positives = 222/628 (35%), Gaps = 118/628 (18%)

Query: 895  PQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKS 954
            P+E+        +A +    ES E+ V    QP +      PK+  +E  EP      ++
Sbjct: 693  PKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERGS----PKKCEAEEAEPPAATQPQT 748

Query: 955  PEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKP------ 1008
             E     L E SER+     E +   +   SE+  E + PE P   +  +          
Sbjct: 749  SETQTSHLPE-SERIHHTVEEKEEVTM-DTSENRPENDVPEPPMPIADQVSNDDRPEGSV 806

Query: 1009 ------------TLKRKKPFLHRRRRV-------------RKRKHHNSSVVTE---TISE 1040
                        + KRK   +   + V             RKR+   S+  T+   +IS 
Sbjct: 807  EDEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISI 866

Query: 1041 TTEVLDEPFEDSDSERPMPRLEPTFEI--DEEEEEEDENELFPREYFRRLSSQDVLRCQS 1098
            TTE L     D    +P+   E   ++  D+    EDE E   R        + +  C++
Sbjct: 867  TTESLKSLIPDI---KPLAGQEAVVDLHADDSRISEDETE---RNGDDGTHDKGLKICRT 920

Query: 1099 -------SSKRKSKDEEEDEESDDADDTPI-----------------LKPVSL---LRKR 1131
                     +   + EEE+EE +   + P+                 +K V+L   L +R
Sbjct: 921  VTQVVPAEGQENGQREEEEEEKEPEAEPPVPPQVSVEVALPPPAEHEVKKVTLGDTLTRR 980

Query: 1132 DV--KNSPLEPDTSTPLKKKK--GWPKGKSRKPIHWKK--RPGRKPGFKLSREIMPVSTQ 1185
             +  + S +      P++  +    P+GK    +H     RP     F L +    +   
Sbjct: 981  SISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVRP-----FTLGQLKELLGRT 1035

Query: 1186 ACVIEPIVSIPKAGRKPKIQES--EETVEPKEDMP-LPEERKEEEEMQAEAEEAEEGEEE 1242
              ++E    I K      +  S  EE V  +  +  +   +   + + A+  E +E +  
Sbjct: 1036 GTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQDELDYH 1095

Query: 1243 DAASSEVPAASPADSSNSPET----------ETKEPEVEEEEEKPRVSEE--QRQSEEEQ 1290
                 + P+ +  +    P              + P  E+ E++  V E+  +R+ E E+
Sbjct: 1096 RGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAEREREMER 1155

Query: 1291 QELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTRED---------- 1340
            +E    E E + D   E  ++     D       +S +KK  +++  +E+          
Sbjct: 1156 RERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLF 1215

Query: 1341 --VKEEPGVQ-----ESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSE 1393
               K  P +      +S +     +  E+ K++E+   + EEE+          +     
Sbjct: 1216 RKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQL 1275

Query: 1394 DDHEEDSHTKEELIELKEEEEIPHSELD 1421
            +  +   H++E   E + E E    + D
Sbjct: 1276 EREKRREHSRERDRERERERERDRGDRD 1303



 Score = 35.0 bits (79), Expect = 0.74
 Identities = 25/97 (25%), Positives = 44/97 (45%), Gaps = 8/97 (8%)

Query: 748  RREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSE--------EEEEEAEEGEN 799
            ++EK  ++  AKL  +L        C+ W P+  S  V  E        E E+  +E E 
Sbjct: 1198 KKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEE 1257

Query: 800  EEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPE 836
            EE + +E+E E    + +  E + + S   + E++ E
Sbjct: 1258 EEQKEREKEAERERNRQLEREKRREHSRERDRERERE 1294



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 14/33 (42%), Positives = 19/33 (57%), Gaps = 2/33 (6%)

Query: 1674 PPQQQPQQQPQPQPQQPPPPPP--PQQQPPLSQ 1704
            P + + ++Q  P+P  PPPPPP  P Q P   Q
Sbjct: 1103 PSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQ 1135


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.127    0.368 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,365,699
Number of Sequences: 37866
Number of extensions: 5774636
Number of successful extensions: 183143
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1906
Number of HSP's successfully gapped in prelim test: 2388
Number of HSP's that attempted gapping in prelim test: 42675
Number of HSP's gapped (non-prelim): 58755
length of query: 2004
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1887
effective length of database: 13,817,196
effective search space: 26073048852
effective search space used: 26073048852
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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