Search of human proteins with 14993776

Search of human proteins with 14993776

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14993776 skeletal myosin light chain kinase [Homo sapiens]
         (596 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14993776 skeletal myosin light chain kinase [Homo sapiens]        1201   0.0  
gi|146219832 myosin light chain kinase 3 [Homo sapiens]               452   e-127
gi|167466233 myosin light chain kinase family, member 4 [Homo sa...   376   e-104
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]       312   5e-85
gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]       312   5e-85
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          236   4e-62
gi|14670383 death-associated kinase 2 [Homo sapiens]                  234   2e-61
gi|4557511 death-associated protein kinase 3 [Homo sapiens]           229   5e-60
gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]      220   3e-57
gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens]      220   3e-57
gi|110349719 titin isoform N2-A [Homo sapiens]                        217   3e-56
gi|110349717 titin isoform novex-2 [Homo sapiens]                     217   3e-56
gi|110349713 titin isoform novex-1 [Homo sapiens]                     217   3e-56
gi|110349715 titin isoform N2-B [Homo sapiens]                        217   3e-56
gi|109255245 serine/threonine kinase 17a [Homo sapiens]               212   9e-55
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor...   201   2e-51
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo...   201   2e-51
gi|4758194 serine/threonine kinase 17B [Homo sapiens]                 197   2e-50
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s...   183   4e-46
gi|27901803 protein serine kinase H1 [Homo sapiens]                   181   2e-45
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ...   179   6e-45
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac...   176   7e-44
gi|157785645 SPEG complex locus [Homo sapiens]                        174   2e-43
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha...   174   3e-43
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha...   174   3e-43
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca...   167   2e-41
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca...   167   2e-41
gi|149589021 doublecortin-like kinase 3 [Homo sapiens]                167   3e-41
gi|14916455 protein serine kinase H2 [Homo sapiens]                   167   3e-41
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo...   166   6e-41

>gi|14993776 skeletal myosin light chain kinase [Homo sapiens]
          Length = 596

 Score = 1201 bits (3106), Expect = 0.0
 Identities = 596/596 (100%), Positives = 596/596 (100%)

Query: 1   MATENGAVELGIQNPSTDKAPKGPTGERPLAAGKDPGPPDPKKAPDPPTLKKDAKAPASE 60
           MATENGAVELGIQNPSTDKAPKGPTGERPLAAGKDPGPPDPKKAPDPPTLKKDAKAPASE
Sbjct: 1   MATENGAVELGIQNPSTDKAPKGPTGERPLAAGKDPGPPDPKKAPDPPTLKKDAKAPASE 60

Query: 61  KGDGTLAQPSTSSQGPKGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGS 120
           KGDGTLAQPSTSSQGPKGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGS
Sbjct: 61  KGDGTLAQPSTSSQGPKGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGS 120

Query: 121 QDPGKPRVGKKAAEGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEGVP 180
           QDPGKPRVGKKAAEGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEGVP
Sbjct: 121 QDPGKPRVGKKAAEGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEGVP 180

Query: 181 MTHSPTDPRPAKAEEGKNILAESQKEVGEKTPGQAGQAKMQGDTSRGIEFQAVPSEKSEV 240
           MTHSPTDPRPAKAEEGKNILAESQKEVGEKTPGQAGQAKMQGDTSRGIEFQAVPSEKSEV
Sbjct: 181 MTHSPTDPRPAKAEEGKNILAESQKEVGEKTPGQAGQAKMQGDTSRGIEFQAVPSEKSEV 240

Query: 241 GQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGGGKFGAVC 300
           GQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGGGKFGAVC
Sbjct: 241 GQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGGGKFGAVC 300

Query: 301 TCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFME 360
           TCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFME
Sbjct: 301 TCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFME 360

Query: 361 YIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGH 420
           YIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGH
Sbjct: 361 YIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGH 420

Query: 421 LVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLS 480
           LVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLS
Sbjct: 421 LVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLS 480

Query: 481 PFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL 540
           PFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL
Sbjct: 481 PFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL 540

Query: 541 NNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV 596
           NNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV
Sbjct: 541 NNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV 596


>gi|146219832 myosin light chain kinase 3 [Homo sapiens]
          Length = 819

 Score =  452 bits (1164), Expect = e-127
 Identities = 267/590 (45%), Positives = 355/590 (60%), Gaps = 53/590 (8%)

Query: 10  LGIQNPSTDKAP---KGPTGERP----LAAGKDPGPPDPKKAPDPPTLKKDAKAPASEKG 62
           + + +PS + AP   +G +  RP    L  G    P    + P PP L   A+A A+  G
Sbjct: 271 VNVVSPSLEVAPGAGQGASSSRPDPEPLEEGTRLTPGPGPQCPGPPGLP--AQARATHSG 328

Query: 63  DGTLAQPSTSSQGPKGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGS-- 120
             T  + S   Q     G+       GS GP       T T E        +QG  G+  
Sbjct: 329 GETPPRISIHIQEMDTPGEMLM-TGRGSLGP-------TLTTEAPAAAQPGKQGPPGTGR 380

Query: 121 --QDPGKPRVGKKAAEGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEG 178
             Q PG    G++  EG   AR  SP  L   S P  + + E+  A   P          
Sbjct: 381 CLQAPGT-EPGEQTPEG---ARELSP--LQESSSPGGVKAEEEQRAGAEPG--------- 425

Query: 179 VPMTHSPTDPRPAKAEEGKNILAESQKEVGEKTPGQAGQAKMQGDTSRGIEFQAVPSEKS 238
                  T P  A++++  + +     + G K+PG AG  + + D +     +A    + 
Sbjct: 426 -------TRPSLARSDDNDHEVGALGLQQG-KSPG-AGNPEPEQDCAARAPVRAEAVRRM 476

Query: 239 EVGQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGGGKFGA 298
             G         E    +LDD P PPAPF HR+V ++  ++S+ + +   E LGGG+FG 
Sbjct: 477 PPGA--------EAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQ 528

Query: 299 VCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLF 358
           V  C EK+TGL LAAK+IK ++ KD+E V  EI +MNQL+H NLIQLY A E+ H   L 
Sbjct: 529 VHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLV 588

Query: 359 MEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTT 418
           MEY++GGELF+RI DE YHLTE+D ++F RQIC+G+ ++H+  +LHLDLKPENILCVN T
Sbjct: 589 MEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQT 648

Query: 419 GHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSG 478
           GH +KIIDFGLARRY P EKLKVNFGTPEFL+PEVVNY+ +S  TDMWS+GVITYMLLSG
Sbjct: 649 GHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSG 708

Query: 479 LSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHP 538
           LSPFLG+ D ET+N +++ +W FD +TFE +S+EAKDFVS L+VK++  RM+A QCL H 
Sbjct: 709 LSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHE 768

Query: 539 WLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSS 588
           WLNNL  KA R   RLKSQ+LL+KY+ +R+WKK+F  V+AANR +K  +S
Sbjct: 769 WLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTS 818


>gi|167466233 myosin light chain kinase family, member 4 [Homo
           sapiens]
          Length = 388

 Score =  376 bits (966), Expect = e-104
 Identities = 178/284 (62%), Positives = 229/284 (80%)

Query: 259 DCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKK 318
           D P PPAPF HR+V  + G V+S ++++  E LGGG+FG V  C E ATGLKLAAK+IK 
Sbjct: 80  DIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKT 139

Query: 319 QTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHL 378
           +  KDKE V  EI VMNQL+H NLIQLY A E+ ++IVL MEY++GGELF+RI+DE Y+L
Sbjct: 140 RGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNL 199

Query: 379 TEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEK 438
           TE+DT++F++QIC+GI  MH+M +LHLDLKPENILCVN     +KIIDFGLARRY P EK
Sbjct: 200 TELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREK 259

Query: 439 LKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGN 498
           LKVNFGTPEFL+PEVVNYD +S  TDMWS+GVI YMLLSGLSPFLGD+D ETLNN+L+  
Sbjct: 260 LKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACR 319

Query: 499 WYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNN 542
           W  ++E F+ +S+EAK+F+S L++K++  R++A++ L HPWL++
Sbjct: 320 WDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSD 363


>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
          Length = 1914

 Score =  312 bits (800), Expect = 5e-85
 Identities = 163/358 (45%), Positives = 227/358 (63%), Gaps = 5/358 (1%)

Query: 234  PSEKSEVGQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGG 293
            PS++SE+          +D  ++ DD    P    +R V + T    S+F  + +E LG 
Sbjct: 1415 PSQESELTTVGEKPEEPKDEVEVSDDDEKEPE-VDYRTVTINTEQKVSDF-YDIEERLGS 1472

Query: 294  GKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPH 353
            GKFG V   +EK T    A K  K  + K+KE +  EI +MN L+H  L+Q   A E   
Sbjct: 1473 GKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKA 1532

Query: 354  EIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENIL 413
             IV+ +E + GGELFERI+DED+ LTE + + ++RQI +G+ ++HK  ++HLDLKPENI+
Sbjct: 1533 NIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIM 1592

Query: 414  CVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITY 473
            CVN TG  +K+IDFGLARR      LKV FGTPEF++PEV+NY+ I   TDMWS+GVI Y
Sbjct: 1593 CVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICY 1652

Query: 474  MLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQ 533
            +L+SGLSPF+GD+D ETL NV S  W FD+E F+ +SD+AKDF+SNL+ KD + R++  Q
Sbjct: 1653 ILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQ 1712

Query: 534  CLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGAL 591
            CL HPW   L +  K    +  S+  +KKY+ +R+W+K   AV A  R   ++    L
Sbjct: 1713 CLQHPW---LMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGL 1767


>gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]
          Length = 1845

 Score =  312 bits (800), Expect = 5e-85
 Identities = 163/358 (45%), Positives = 227/358 (63%), Gaps = 5/358 (1%)

Query: 234  PSEKSEVGQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGG 293
            PS++SE+          +D  ++ DD    P    +R V + T    S+F  + +E LG 
Sbjct: 1346 PSQESELTTVGEKPEEPKDEVEVSDDDEKEPE-VDYRTVTINTEQKVSDF-YDIEERLGS 1403

Query: 294  GKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPH 353
            GKFG V   +EK T    A K  K  + K+KE +  EI +MN L+H  L+Q   A E   
Sbjct: 1404 GKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKA 1463

Query: 354  EIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENIL 413
             IV+ +E + GGELFERI+DED+ LTE + + ++RQI +G+ ++HK  ++HLDLKPENI+
Sbjct: 1464 NIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIM 1523

Query: 414  CVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITY 473
            CVN TG  +K+IDFGLARR      LKV FGTPEF++PEV+NY+ I   TDMWS+GVI Y
Sbjct: 1524 CVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICY 1583

Query: 474  MLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQ 533
            +L+SGLSPF+GD+D ETL NV S  W FD+E F+ +SD+AKDF+SNL+ KD + R++  Q
Sbjct: 1584 ILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQ 1643

Query: 534  CLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGAL 591
            CL HPW   L +  K    +  S+  +KKY+ +R+W+K   AV A  R   ++    L
Sbjct: 1644 CLQHPW---LMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGL 1698


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  236 bits (602), Expect = 4e-62
 Identities = 129/338 (38%), Positives = 199/338 (58%), Gaps = 22/338 (6%)

Query: 271 MVELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKD------K 324
           M   R  NV   +  ++ E LG G+F  V  C EK+TGL+ AAK IKK+  K       +
Sbjct: 1   MTVFRQENVDDYY--DTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSR 58

Query: 325 EMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTM 384
           E +  E+ ++ ++ H N+I L+   E   +++L +E + GGELF+ + +++  LTE +  
Sbjct: 59  EDIEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKE-SLTEEEAT 117

Query: 385 VFVRQICDGILFMHKMRVLHLDLKPENILCV--NTTGHLVKIIDFGLARRYNPNEKLKVN 442
            F++QI +G+ ++H +++ H DLKPENI+ +  N     +KIIDFGLA + +   + K  
Sbjct: 118 EFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNI 177

Query: 443 FGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFD 502
           FGTPEF++PE+VNY+ +  + DMWS+GVITY+LLSG SPFLGD   ETL NV + N+ F+
Sbjct: 178 FGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFE 237

Query: 503 EETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL------NNLAEKAKRCNRRLKS 556
           +E F   S  AKDF+  L+VKD + RM     L HPW+        L+ KA   N     
Sbjct: 238 DEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNME--- 294

Query: 557 QILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMAL 594
               KK+  +++WK++   +S   R  +   S + M++
Sbjct: 295 --KFKKFAARKKWKQSVRLISLCQRLSRSFLSRSNMSV 330


>gi|14670383 death-associated kinase 2 [Homo sapiens]
          Length = 370

 Score =  234 bits (597), Expect = 2e-61
 Identities = 121/305 (39%), Positives = 185/305 (60%), Gaps = 10/305 (3%)

Query: 289 EALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPK------DKEMVLLEIEVMNQLNHRNL 342
           E LG G+F  V  C EK+TGL+ AAK IKK+  +       +E +  E+ ++ Q+ H N+
Sbjct: 27  EELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNV 86

Query: 343 IQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRV 402
           I L+   E   ++VL +E + GGELF+ +  ++  L+E +   F++QI DG+ ++H  ++
Sbjct: 87  ITLHDVYENRTDVVLILELVSGGELFDFLAQKE-SLSEEEATSFIKQILDGVNYLHTKKI 145

Query: 403 LHLDLKPENILCVNTTGHL--VKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQIS 460
            H DLKPENI+ ++    +  +K+IDFGLA       + K  FGTPEF++PE+VNY+ + 
Sbjct: 146 AHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLG 205

Query: 461 DKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNL 520
            + DMWS+GVITY+LLSG SPFLGD   ETL N+ + ++ FDEE F   S+ AKDF+  L
Sbjct: 206 LEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKL 265

Query: 521 IVKDQRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQI-LLKKYLMKRRWKKNFIAVSAA 579
           +VK+ R R+   + L HPW+  +  +     R     +   +K  ++RRWK +F  VS  
Sbjct: 266 LVKETRKRLTIQEALRHPWITPVDNQQAMVRRESVVNLENFRKQYVRRRWKLSFSIVSLC 325

Query: 580 NRFKK 584
           N   +
Sbjct: 326 NHLTR 330


>gi|4557511 death-associated protein kinase 3 [Homo sapiens]
          Length = 454

 Score =  229 bits (584), Expect = 5e-60
 Identities = 122/311 (39%), Positives = 183/311 (58%), Gaps = 18/311 (5%)

Query: 271 MVELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKD------K 324
           M   R  +V   + M   E LG G+F  V  C +K TG + AAK IKK+          +
Sbjct: 1   MSTFRQEDVEDHYEMG--EELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSR 58

Query: 325 EMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTM 384
           E +  E+ ++ ++ H N+I L+   E   ++VL +E + GGELF+ + +++  LTE +  
Sbjct: 59  EEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKE-SLTEDEAT 117

Query: 385 VFVRQICDGILFMHKMRVLHLDLKPENILCV--NTTGHLVKIIDFGLARRYNPNEKLKVN 442
            F++QI DG+ ++H  R+ H DLKPENI+ +  N     +K+IDFG+A +     + K  
Sbjct: 118 QFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNI 177

Query: 443 FGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFD 502
           FGTPEF++PE+VNY+ +  + DMWS+GVITY+LLSG SPFLG+   ETL N+ + N+ FD
Sbjct: 178 FGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFD 237

Query: 503 EETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNL-------AEKAKRCNRRLK 555
           EE F   S+ AKDF+  L+VKD + RM  AQ L H W+  +        +  ++  RR  
Sbjct: 238 EEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGEDSGRKPERRRL 297

Query: 556 SQILLKKYLMK 566
               LK+Y +K
Sbjct: 298 KTTRLKEYTIK 308


>gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]
          Length = 1863

 Score =  220 bits (560), Expect = 3e-57
 Identities = 132/358 (36%), Positives = 186/358 (51%), Gaps = 56/358 (15%)

Query: 234  PSEKSEVGQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGG 293
            PS++SE+          +D  ++ DD    P    +R V + T    S+F  + +E LG 
Sbjct: 1415 PSQESELTTVGEKPEEPKDEVEVSDDDEKEPE-VDYRTVTINTEQKVSDF-YDIEERLGS 1472

Query: 294  GKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPH 353
            GKFG V   +EK T    A K  K  + K+KE +  EI +MN L+H  L+Q   A E   
Sbjct: 1473 GKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKA 1532

Query: 354  EIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENIL 413
             IV+ +E + GGELFERI+DED+ LTE + + ++RQI +G+ ++HK  ++HLDLKPENI+
Sbjct: 1533 NIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIM 1592

Query: 414  CVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITY 473
            CVN TG  +K+IDFGLARR      LKV FGTPEF++PEV+NY+ I   TDMWS+GVI Y
Sbjct: 1593 CVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICY 1652

Query: 474  MLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQ 533
            +L                                                    R++  Q
Sbjct: 1653 IL---------------------------------------------------NRLDCTQ 1661

Query: 534  CLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGAL 591
            CL HPW   L +  K    +  S+  +KKY+ +R+W+K   AV A  R   ++    L
Sbjct: 1662 CLQHPW---LMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGL 1716


>gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens]
          Length = 1794

 Score =  220 bits (560), Expect = 3e-57
 Identities = 132/358 (36%), Positives = 186/358 (51%), Gaps = 56/358 (15%)

Query: 234  PSEKSEVGQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGG 293
            PS++SE+          +D  ++ DD    P    +R V + T    S+F  + +E LG 
Sbjct: 1346 PSQESELTTVGEKPEEPKDEVEVSDDDEKEPE-VDYRTVTINTEQKVSDF-YDIEERLGS 1403

Query: 294  GKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPH 353
            GKFG V   +EK T    A K  K  + K+KE +  EI +MN L+H  L+Q   A E   
Sbjct: 1404 GKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKA 1463

Query: 354  EIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENIL 413
             IV+ +E + GGELFERI+DED+ LTE + + ++RQI +G+ ++HK  ++HLDLKPENI+
Sbjct: 1464 NIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIM 1523

Query: 414  CVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITY 473
            CVN TG  +K+IDFGLARR      LKV FGTPEF++PEV+NY+ I   TDMWS+GVI Y
Sbjct: 1524 CVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICY 1583

Query: 474  MLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQ 533
            +L                                                    R++  Q
Sbjct: 1584 IL---------------------------------------------------NRLDCTQ 1592

Query: 534  CLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGAL 591
            CL HPW   L +  K    +  S+  +KKY+ +R+W+K   AV A  R   ++    L
Sbjct: 1593 CLQHPW---LMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGL 1647


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score =  217 bits (552), Expect = 3e-56
 Identities = 109/303 (35%), Positives = 184/303 (60%), Gaps = 8/303 (2%)

Query: 289   EALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAA 348
             E LG G+FG V  C+E ++     AK +K +   D+ +V  EI ++N   HRN++ L+ +
Sbjct: 31255 EDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGT-DQVLVKKEISILNIARHRNILHLHES 31313

Query: 349   IETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLK 408
              E+  E+V+  E+I G ++FERI    + L E + + +V Q+C+ + F+H   + H D++
Sbjct: 31314 FESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHFDIR 31373

Query: 409   PENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSM 468
             PENI+        +KII+FG AR+  P +  ++ F  PE+ +PEV  +D +S  TDMWS+
Sbjct: 31374 PENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDMWSL 31433

Query: 469   GVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRAR 528
             G + Y+LLSG++PFL + + + + N+++  + FDEE F+ +S EA DFV  L+VK++++R
Sbjct: 31434 GTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSR 31493

Query: 529   MNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSS 588
             M A++ L HPWL    +K +R + ++   +  ++Y      K   + VSAA    +IS  
Sbjct: 31494 MTASEALQHPWLK---QKIERVSTKVIRTLKHRRYYHTLIKKDLNMVVSAA----RISCG 31546

Query: 589   GAL 591
             GA+
Sbjct: 31547 GAI 31549



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 67/278 (24%), Positives = 102/278 (36%), Gaps = 35/278 (12%)

Query: 19    KAPKGPTGERPLAAGKDPGPPDPKKAPDPPTLKKDA-KAPASEKGDGTLAQPSTSSQGPK 77
             K P+ P    P    K P PP PKK   PPT   +  K    EK       P   S  P+
Sbjct: 10608 KVPEAPKEVVP--EKKVPVPP-PKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPE 10664

Query: 78    -----GEGDRGGGPAEGSAGP-PAALPQQTATPETSVKKPKAEQGASGSQDPGKPRVGKK 131
                   E      PAE    P PAA PQ T  P+  V + KA   A  ++ P  P V   
Sbjct: 10665 VFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAP--AVVAKKPELPPVKVP 10722

Query: 132   AAEGQAAARRGSPAFLHS---------PSCPAIISSSEKLLAKK----PPSEASELTFEG 178
                 +    +  P  +           P  P  +   +K+   K    PP++  E+  + 
Sbjct: 10723 EVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKP 10782

Query: 179   VPMTHSPTDPRPAKAEEGKNILAESQKEVG---EKTPGQAGQAKMQGDTSRGIEFQAVPS 235
             V +   P  P P +AE     + E  +E+    E  P +     +  +    +   AVP 
Sbjct: 10783 V-LEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPE 10841

Query: 236   EKSEVGQALCLTAREEDCFQILDDCPPPPAPFPHRMVE 273
             E  ++     +   ++       + PPP  P P +++E
Sbjct: 10842 EPKKIIPEKKVPVIKKP------EAPPPKEPEPEKVIE 10873



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 45/183 (24%), Positives = 62/183 (33%), Gaps = 12/183 (6%)

Query: 21    PKGPTGERPLAAGKDPGPPDPKKAPDPPT-LKKDAKAPASEKGDGTLAQPSTSSQGPK-G 78
             PK P   + +   K    P PKK   PPT + +  KA   EK       P   S  P+  
Sbjct: 10523 PKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVP 10582

Query: 79    EGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGSQDPGKPRVG-------KK 131
             E  +   P +     P   P+ T        K    +       P KP V         K
Sbjct: 10583 EAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPK 10642

Query: 132   AAEGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEGVP--MTHSPTDPR 189
              A  +       P    SP  P +    E++  ++PP+E  E      P  +T  P  P 
Sbjct: 10643 VAVPEKKVPEAIPPKPESPP-PEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPV 10701

Query: 190   PAK 192
             P K
Sbjct: 10702 PEK 10704



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 24/86 (27%), Positives = 34/86 (39%), Gaps = 2/86 (2%)

Query: 39    PDPKKAPDPPTLKKDAKAPASEKGDGTLAQPST-SSQGPKGEGDRGGGPAEGSAGPPAAL 97
             P P+  P P    K  K P  E     +A P T    G K E       A    GP   +
Sbjct: 11017 PAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGV 11076

Query: 98    PQQTATPETSVKKPKAEQGASGSQDP 123
             P++T +P    ++ K   G+ G + P
Sbjct: 11077 PKKTPSP-IEAERRKLRPGSGGEKPP 11101



 Score = 32.0 bits (71), Expect = 1.7
 Identities = 53/261 (20%), Positives = 87/261 (33%), Gaps = 39/261 (14%)

Query: 19    KAPKGPTGERPLAAGKDPGPPDPK--KAPDPPTLKKDAKAPASEKGDGTLAQPSTSSQGP 76
             + PK    E+ +A  K P  P  K  + P  P L++    P  E+ +             
Sbjct: 10751 EVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESP----------- 10799

Query: 77    KGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGSQDPGKPRVGKK-AAEG 135
                      P E    P    P++   PE     P AE+       P  P   KK   E 
Sbjct: 10800 ---------PPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEK 10850

Query: 136   QAAARRGSPAFLHSPSCPAIISSSEKLLAKKPP-------SEASELTFE--GVPMTHSPT 186
             +    +   A       P  +    KL  + PP        +  E  F+   +P    P 
Sbjct: 10851 KVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPE 10910

Query: 187   DPR-PAKAEEGKNILAESQKEVGEKTPGQAGQAKMQGDTSRGIEFQAVPSEKSEVGQALC 245
              P+ P K E     +   +K+V +  P +  + K +      +  ++V  ++ E  +   
Sbjct: 10911 KPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEE------VVLKSVLRKRPEEEEPKV 10964

Query: 246   LTAREEDCFQILDDCPPPPAP 266
                + E   +     PPPP P
Sbjct: 10965 EPKKLEKVKKPAVPEPPPPKP 10985



 Score = 31.2 bits (69), Expect = 2.8
 Identities = 48/197 (24%), Positives = 69/197 (35%), Gaps = 36/197 (18%)

Query: 15   PSTDKAPKGPTGERPLAAGKDPGPPDPKKAPDPPTLKKDAKAPASEKGDGTLAQPSTSSQ 74
            P   K P+ P  ++P+   K P P   K+   PP + +  K P  E+    +  P     
Sbjct: 9311 PPAPKVPEVP--KKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEE---KIPVP----- 9360

Query: 75   GPKGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGSQDPGKPRV-GKKAA 133
                        A+    PPA +P+      T  K     Q    S  P  P +  KK  
Sbjct: 9361 -----------VAKKKEAPPAKVPEVQKGVVTEEKITIVTQ-REESPPPAVPEIPKKKVP 9408

Query: 134  EGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEGVPMTHSPTDPRPAKA 193
            E +    R        P  PA        L KKP  E        VP+  +   P P +A
Sbjct: 9409 EERKPVPRKEEEVPPPPKVPA--------LPKKPVPEEK----VAVPVPVAKKAP-PPRA 9455

Query: 194  EEGKNILAESQKEVGEK 210
            E  K  + E ++ V E+
Sbjct: 9456 EVSKKTVVEEKRFVAEE 9472



 Score = 30.4 bits (67), Expect = 4.8
 Identities = 13/31 (41%), Positives = 17/31 (54%)

Query: 24    PTGERPLAAGKDPGPPDPKKAPDPPTLKKDA 54
             P    P+ A    GPPDP K P+  T+ KD+
Sbjct: 21640 PLESEPVLAVNPYGPPDPPKNPEVTTITKDS 21670


>gi|110349717 titin isoform novex-2 [Homo sapiens]
          Length = 27118

 Score =  217 bits (552), Expect = 3e-56
 Identities = 109/303 (35%), Positives = 184/303 (60%), Gaps = 8/303 (2%)

Query: 289   EALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAA 348
             E LG G+FG V  C+E ++     AK +K +   D+ +V  EI ++N   HRN++ L+ +
Sbjct: 24950 EDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGT-DQVLVKKEISILNIARHRNILHLHES 25008

Query: 349   IETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLK 408
              E+  E+V+  E+I G ++FERI    + L E + + +V Q+C+ + F+H   + H D++
Sbjct: 25009 FESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHFDIR 25068

Query: 409   PENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSM 468
             PENI+        +KII+FG AR+  P +  ++ F  PE+ +PEV  +D +S  TDMWS+
Sbjct: 25069 PENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDMWSL 25128

Query: 469   GVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRAR 528
             G + Y+LLSG++PFL + + + + N+++  + FDEE F+ +S EA DFV  L+VK++++R
Sbjct: 25129 GTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSR 25188

Query: 529   MNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSS 588
             M A++ L HPWL    +K +R + ++   +  ++Y      K   + VSAA    +IS  
Sbjct: 25189 MTASEALQHPWLK---QKIERVSTKVIRTLKHRRYYHTLIKKDLNMVVSAA----RISCG 25241

Query: 589   GAL 591
             GA+
Sbjct: 25242 GAI 25244



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 24/86 (27%), Positives = 34/86 (39%), Gaps = 2/86 (2%)

Query: 39   PDPKKAPDPPTLKKDAKAPASEKGDGTLAQPST-SSQGPKGEGDRGGGPAEGSAGPPAAL 97
            P P+  P P    K  K P  E     +A P T    G K E       A    GP   +
Sbjct: 4712 PAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGV 4771

Query: 98   PQQTATPETSVKKPKAEQGASGSQDP 123
            P++T +P    ++ K   G+ G + P
Sbjct: 4772 PKKTPSP-IEAERRKLRPGSGGEKPP 4796



 Score = 30.4 bits (67), Expect = 4.8
 Identities = 13/31 (41%), Positives = 17/31 (54%)

Query: 24    PTGERPLAAGKDPGPPDPKKAPDPPTLKKDA 54
             P    P+ A    GPPDP K P+  T+ KD+
Sbjct: 15335 PLESEPVLAVNPYGPPDPPKNPEVTTITKDS 15365


>gi|110349713 titin isoform novex-1 [Homo sapiens]
          Length = 27051

 Score =  217 bits (552), Expect = 3e-56
 Identities = 109/303 (35%), Positives = 184/303 (60%), Gaps = 8/303 (2%)

Query: 289   EALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAA 348
             E LG G+FG V  C+E ++     AK +K +   D+ +V  EI ++N   HRN++ L+ +
Sbjct: 24883 EDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGT-DQVLVKKEISILNIARHRNILHLHES 24941

Query: 349   IETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLK 408
              E+  E+V+  E+I G ++FERI    + L E + + +V Q+C+ + F+H   + H D++
Sbjct: 24942 FESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHFDIR 25001

Query: 409   PENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSM 468
             PENI+        +KII+FG AR+  P +  ++ F  PE+ +PEV  +D +S  TDMWS+
Sbjct: 25002 PENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDMWSL 25061

Query: 469   GVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRAR 528
             G + Y+LLSG++PFL + + + + N+++  + FDEE F+ +S EA DFV  L+VK++++R
Sbjct: 25062 GTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSR 25121

Query: 529   MNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSS 588
             M A++ L HPWL    +K +R + ++   +  ++Y      K   + VSAA    +IS  
Sbjct: 25122 MTASEALQHPWLK---QKIERVSTKVIRTLKHRRYYHTLIKKDLNMVVSAA----RISCG 25174

Query: 589   GAL 591
             GA+
Sbjct: 25175 GAI 25177



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 24/86 (27%), Positives = 34/86 (39%), Gaps = 2/86 (2%)

Query: 39   PDPKKAPDPPTLKKDAKAPASEKGDGTLAQPST-SSQGPKGEGDRGGGPAEGSAGPPAAL 97
            P P+  P P    K  K P  E     +A P T    G K E       A    GP   +
Sbjct: 4645 PAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGV 4704

Query: 98   PQQTATPETSVKKPKAEQGASGSQDP 123
            P++T +P    ++ K   G+ G + P
Sbjct: 4705 PKKTPSP-IEAERRKLRPGSGGEKPP 4729



 Score = 30.4 bits (67), Expect = 4.8
 Identities = 13/31 (41%), Positives = 17/31 (54%)

Query: 24    PTGERPLAAGKDPGPPDPKKAPDPPTLKKDA 54
             P    P+ A    GPPDP K P+  T+ KD+
Sbjct: 15268 PLESEPVLAVNPYGPPDPPKNPEVTTITKDS 15298


>gi|110349715 titin isoform N2-B [Homo sapiens]
          Length = 26926

 Score =  217 bits (552), Expect = 3e-56
 Identities = 109/303 (35%), Positives = 184/303 (60%), Gaps = 8/303 (2%)

Query: 289   EALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAA 348
             E LG G+FG V  C+E ++     AK +K +   D+ +V  EI ++N   HRN++ L+ +
Sbjct: 24758 EDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGT-DQVLVKKEISILNIARHRNILHLHES 24816

Query: 349   IETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLK 408
              E+  E+V+  E+I G ++FERI    + L E + + +V Q+C+ + F+H   + H D++
Sbjct: 24817 FESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHFDIR 24876

Query: 409   PENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSM 468
             PENI+        +KII+FG AR+  P +  ++ F  PE+ +PEV  +D +S  TDMWS+
Sbjct: 24877 PENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDMWSL 24936

Query: 469   GVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRAR 528
             G + Y+LLSG++PFL + + + + N+++  + FDEE F+ +S EA DFV  L+VK++++R
Sbjct: 24937 GTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSR 24996

Query: 529   MNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSS 588
             M A++ L HPWL    +K +R + ++   +  ++Y      K   + VSAA    +IS  
Sbjct: 24997 MTASEALQHPWLK---QKIERVSTKVIRTLKHRRYYHTLIKKDLNMVVSAA----RISCG 25049

Query: 589   GAL 591
             GA+
Sbjct: 25050 GAI 25052



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 24/86 (27%), Positives = 34/86 (39%), Gaps = 2/86 (2%)

Query: 39   PDPKKAPDPPTLKKDAKAPASEKGDGTLAQPST-SSQGPKGEGDRGGGPAEGSAGPPAAL 97
            P P+  P P    K  K P  E     +A P T    G K E       A    GP   +
Sbjct: 4520 PAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGV 4579

Query: 98   PQQTATPETSVKKPKAEQGASGSQDP 123
            P++T +P    ++ K   G+ G + P
Sbjct: 4580 PKKTPSP-IEAERRKLRPGSGGEKPP 4604



 Score = 30.4 bits (67), Expect = 4.8
 Identities = 13/31 (41%), Positives = 17/31 (54%)

Query: 24    PTGERPLAAGKDPGPPDPKKAPDPPTLKKDA 54
             P    P+ A    GPPDP K P+  T+ KD+
Sbjct: 15143 PLESEPVLAVNPYGPPDPPKNPEVTTITKDS 15173


>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
          Length = 414

 Score =  212 bits (539), Expect = 9e-55
 Identities = 119/315 (37%), Positives = 188/315 (59%), Gaps = 12/315 (3%)

Query: 260 CPPPPAPFPHRMVE-----LRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAK 314
           C PPP P    ++      +RT      +S+     LG GKF  V  C++K +G + AAK
Sbjct: 31  CRPPPPPQARGLLTEIRAVVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAK 90

Query: 315 VIKKQTP-KDKEMVLLEIEVMNQLNHRN--LIQLYAAIETPHEIVLFMEYIEGGELFERI 371
            ++K+   +D  M ++    + +L   N  +I L+   ET  E++L +EY  GGE+F++ 
Sbjct: 91  FMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQC 150

Query: 372 V-DEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTG-HLVKIIDFGL 429
           V D +    E D    +RQI +G+ F+H   V+HLDLKP+NIL  + +    +KI+DFGL
Sbjct: 151 VADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGL 210

Query: 430 ARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTE 489
           +R    +E+L+   GTPE+++PE+++YD IS  TDMWS+GV+TY++L+G+SPFLG+D  E
Sbjct: 211 SRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQE 270

Query: 490 TLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL--NNLAEKA 547
           T  N+   N  + EE F+ +S+ A DF+  L+VK    R  A +CL HPWL  +++ E +
Sbjct: 271 TFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPS 330

Query: 548 KRCNRRLKSQILLKK 562
            R  + L+    L++
Sbjct: 331 FRMEKALEEANALQE 345


>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
           [Homo sapiens]
          Length = 357

 Score =  201 bits (510), Expect = 2e-51
 Identities = 106/306 (34%), Positives = 167/306 (54%), Gaps = 5/306 (1%)

Query: 288 KEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLL-EIEVMNQLNHRNLIQLY 346
           KE LG G F  V    EKATG   A K I K+  K KE  +  EI V+ ++ H N++ L 
Sbjct: 26  KETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALE 85

Query: 347 AAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLD 406
              E+P+ + L M+ + GGELF+RIV++ ++ TE D    +RQ+ D + ++H+M ++H D
Sbjct: 86  DIYESPNHLYLVMQLVSGGELFDRIVEKGFY-TEKDASTLIRQVLDAVYYLHRMGIVHRD 144

Query: 407 LKPENILCVNTTGHL-VKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDM 465
           LKPEN+L  +      + I DFGL++     + +    GTP +++PEV+     S   D 
Sbjct: 145 LKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDC 204

Query: 466 WSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQ 525
           WS+GVI Y+LL G  PF  ++D++    +L   + FD   ++ +SD AKDF+ NL+ KD 
Sbjct: 205 WSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDP 264

Query: 526 RARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKI 585
             R    Q   HPW+       K  +  + +QI  +K   K +W++ F A +     +K+
Sbjct: 265 NKRYTCEQAARHPWIAGDTALNKNIHESVSAQI--RKNFAKSKWRQAFNATAVVRHMRKL 322

Query: 586 SSSGAL 591
               +L
Sbjct: 323 HLGSSL 328


>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
           2 [Homo sapiens]
          Length = 385

 Score =  201 bits (510), Expect = 2e-51
 Identities = 106/306 (34%), Positives = 167/306 (54%), Gaps = 5/306 (1%)

Query: 288 KEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLL-EIEVMNQLNHRNLIQLY 346
           KE LG G F  V    EKATG   A K I K+  K KE  +  EI V+ ++ H N++ L 
Sbjct: 26  KETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALE 85

Query: 347 AAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLD 406
              E+P+ + L M+ + GGELF+RIV++ ++ TE D    +RQ+ D + ++H+M ++H D
Sbjct: 86  DIYESPNHLYLVMQLVSGGELFDRIVEKGFY-TEKDASTLIRQVLDAVYYLHRMGIVHRD 144

Query: 407 LKPENILCVNTTGHL-VKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDM 465
           LKPEN+L  +      + I DFGL++     + +    GTP +++PEV+     S   D 
Sbjct: 145 LKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDC 204

Query: 466 WSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQ 525
           WS+GVI Y+LL G  PF  ++D++    +L   + FD   ++ +SD AKDF+ NL+ KD 
Sbjct: 205 WSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDP 264

Query: 526 RARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKI 585
             R    Q   HPW+       K  +  + +QI  +K   K +W++ F A +     +K+
Sbjct: 265 NKRYTCEQAARHPWIAGDTALNKNIHESVSAQI--RKNFAKSKWRQAFNATAVVRHMRKL 322

Query: 586 SSSGAL 591
               +L
Sbjct: 323 HLGSSL 328


>gi|4758194 serine/threonine kinase 17B [Homo sapiens]
          Length = 372

 Score =  197 bits (501), Expect = 2e-50
 Identities = 108/275 (39%), Positives = 170/275 (61%), Gaps = 8/275 (2%)

Query: 272 VELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKD--KEMVLL 329
           + ++  N ++ + + SKE LG GKF  V  C+ K+TG + AAK +KK+      +  +L 
Sbjct: 21  IPIKMENFNNFYILTSKE-LGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILH 79

Query: 330 EIEVMNQLNH-RNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHL-TEVDTMVFV 387
           EI V+        +I L+   E   EI+L +EY  GGE+F   + E   + +E D +  +
Sbjct: 80  EIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLI 139

Query: 388 RQICDGILFMHKMRVLHLDLKPENILC--VNTTGHLVKIIDFGLARRYNPNEKLKVNFGT 445
           +QI +G+ ++H+  ++HLDLKP+NIL   +   G  +KI+DFG++R+     +L+   GT
Sbjct: 140 KQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGD-IKIVDFGMSRKIGHACELREIMGT 198

Query: 446 PEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEET 505
           PE+L+PE++NYD I+  TDMW++G+I YMLL+  SPF+G+D+ ET  N+   N  + EET
Sbjct: 199 PEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEET 258

Query: 506 FEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL 540
           F +VS  A DF+ +L+VK+   R  A  CL+H WL
Sbjct: 259 FSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWL 293


>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
           sapiens]
          Length = 370

 Score =  183 bits (464), Expect = 4e-46
 Identities = 100/300 (33%), Positives = 162/300 (54%), Gaps = 5/300 (1%)

Query: 288 KEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLL-EIEVMNQLNHRNLIQLY 346
           ++ LG G F  V    +K T   +A K I K+  + KE  +  EI V++++ H N++ L 
Sbjct: 23  RDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALD 82

Query: 347 AAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLD 406
              E+   + L M+ + GGELF+RIV++ ++ TE D    + Q+ D + ++H + ++H D
Sbjct: 83  DIYESGGHLYLIMQLVSGGELFDRIVEKGFY-TERDASRLIFQVLDAVKYLHDLGIVHRD 141

Query: 407 LKPENILCVNTT-GHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDM 465
           LKPEN+L  +      + I DFGL++  +P   L    GTP +++PEV+     S   D 
Sbjct: 142 LKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDC 201

Query: 466 WSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQ 525
           WS+GVI Y+LL G  PF  ++D +    +L   + FD   ++ +SD AKDF+ +L+ KD 
Sbjct: 202 WSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDP 261

Query: 526 RARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKI 585
             R    Q L HPW+       K  ++ +  QI  KK   K +WK+ F A +     +K+
Sbjct: 262 EKRFTCEQALQHPWIAGDTALDKNIHQSVSEQI--KKNFAKSKWKQAFNATAVVRHMRKL 319


>gi|27901803 protein serine kinase H1 [Homo sapiens]
          Length = 424

 Score =  181 bits (458), Expect = 2e-45
 Identities = 108/309 (34%), Positives = 170/309 (55%), Gaps = 10/309 (3%)

Query: 261 PPPPAPFPHRMVELRTG---NVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIK 317
           PP   P   R+ + R      V++++ +  K  +G G F  V     +AT    A K+I+
Sbjct: 73  PPSEPPRRARVAKYRAKFDPRVTAKYDI--KALIGRGSFSRVVRVEHRATRQPYAIKMIE 130

Query: 318 KQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYH 377
            +  + +E+   E+ V+ ++ H N+IQL    ET   + + ME   GGELF+RI+ +   
Sbjct: 131 TKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKG-S 189

Query: 378 LTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNT-TGHLVKIIDFGLA--RRYN 434
            TE D    ++ + DG+ ++H + + H DLKPEN+L  +  T   + I DFGLA  R+  
Sbjct: 190 FTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKG 249

Query: 435 PNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNV 494
            +  +K   GTPE+++PEV+     ++  DMW++GVI Y+LLSG  PF  D+ T     +
Sbjct: 250 DDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQI 309

Query: 495 LSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRCN-RR 553
           L G + +  E + +VS+ AKDF+  L+  D  ARM A Q L HPW+ ++A  +   N  R
Sbjct: 310 LRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHR 369

Query: 554 LKSQILLKK 562
             SQ LLK+
Sbjct: 370 SISQNLLKR 378


>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
           sapiens]
          Length = 473

 Score =  179 bits (454), Expect = 6e-45
 Identities = 114/312 (36%), Positives = 171/312 (54%), Gaps = 10/312 (3%)

Query: 279 VSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLN 338
           +S  F + S+  LG G    V  C +K T    A KV+KK    DK++V  EI V+ +L+
Sbjct: 42  LSDFFEVESE--LGRGATSIVYRCKQKGTQKPYALKVLKKTV--DKKIVRTEIGVLLRLS 97

Query: 339 HRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMH 398
           H N+I+L    ETP EI L +E + GGELF+RIV++ Y+ +E D    V+QI + + ++H
Sbjct: 98  HPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYY-SERDAADAVKQILEAVAYLH 156

Query: 399 KMRVLHLDLKPENILCVNTTGHL-VKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYD 457
           +  ++H DLKPEN+L         +KI DFGL++       +K   GTP + +PE++   
Sbjct: 157 ENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGC 216

Query: 458 QISDKTDMWSMGVITYMLLSGLSPFLGD-DDTETLNNVLSGNWYFDEETFEAVSDEAKDF 516
               + DMWS+G+ITY+LL G  PF  +  D      +L+  +YF    ++ VS  AKD 
Sbjct: 217 AYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDL 276

Query: 517 VSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAV 576
           V  LIV D + R+   Q L HPW+     KA        +Q  L+++  +R+ K    AV
Sbjct: 277 VRKLIVLDPKKRLTTFQALQHPWVTG---KAANFVHMDTAQKKLQEFNARRKLKAAVKAV 333

Query: 577 SAANRFKKISSS 588
            A++R    SSS
Sbjct: 334 VASSRLGSASSS 345


>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
            RhoGEF isoform b [Homo sapiens]
          Length = 7968

 Score =  176 bits (445), Expect = 7e-44
 Identities = 99/290 (34%), Positives = 164/290 (56%), Gaps = 9/290 (3%)

Query: 288  KEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYA 347
            KE +G G FG V     K   +  AAK I  ++ + +     E +++  L+H  +  L  
Sbjct: 6471 KEEIGRGVFGFVKRVQHKGNKILCAAKFIPLRS-RTRAQAYRERDILAALSHPLVTGLLD 6529

Query: 348  AIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDL 407
              ET   ++L +E     EL +R+  +   +TE +  V+++Q+ +G+ ++H   VLHLD+
Sbjct: 6530 QFETRKTLILILELCSSEELLDRLYRKGV-VTEAEVKVYIQQLVEGLHYLHSHGVLHLDI 6588

Query: 408  KPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWS 467
            KP NIL V+     +KI DFG A+   P E     +G+PEF+SPE++  + +S+ +D+W+
Sbjct: 6589 KPSNILMVHPAREDIKICDFGFAQNITPAELQFSQYGSPEFVSPEIIQQNPVSEASDIWA 6648

Query: 468  MGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRA 527
            MGVI+Y+ L+  SPF G+ D  TL NVL G   +       +S++AKDF+   + +  +A
Sbjct: 6649 MGVISYLSLTCSSPFAGESDRATLLNVLEGRVSWSSPMAAHLSEDAKDFIKATLQRAPQA 6708

Query: 528  RMNAAQCLAHPWL--NNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIA 575
            R +AAQCL+HPW   +  AE+A   N +      LK  L + RW+++ ++
Sbjct: 6709 RPSAAQCLSHPWFLKSMPAEEAHFINTK-----QLKFLLARSRWQRSLMS 6753



 Score =  115 bits (289), Expect = 9e-26
 Identities = 80/264 (30%), Positives = 132/264 (50%), Gaps = 16/264 (6%)

Query: 294  GKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPH 353
            G+F  V  C EKA+G  LAAK+I    PKDK  VL E E +  L H +L QL+AA  +P 
Sbjct: 7681 GRFSVVRQCWEKASGRALAAKIIPYH-PKDKTAVLREYEALKGLRHPHLAQLHAAYLSPR 7739

Query: 354  EIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENIL 413
             +VL +E   G EL   + +   + +E +   ++ Q+     ++H   +LHLDL+ EN++
Sbjct: 7740 HLVLILELCSGPELLPCLAERASY-SESEVKDYLWQMLSATQYLHNQHILHLDLRSENMI 7798

Query: 414  CVNTTGHLVKIIDFGLARRYN-----PNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSM 468
               T  +L+K++D G A+  +     P++K K      E ++PE++       +TD+W++
Sbjct: 7799 I--TEYNLLKVVDLGNAQSLSQEKVLPSDKFKDYL---ETMAPELLEGQGAVPQTDIWAI 7853

Query: 469  GVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRAR 528
            GV  +++LS   P +  +    L   L          +  +S  A  F+ + +      R
Sbjct: 7854 GVTAFIMLSAEYP-VSSEGARDLQRGLRKGLVRLSRCYAGLSGGAVAFLRSTLCAQPWGR 7912

Query: 529  MNAAQCLAHPWLNNLAEKAKRCNR 552
              A+ CL  PW   L E+   C+R
Sbjct: 7913 PCASSCLQCPW---LTEEGPACSR 7933



 Score = 31.2 bits (69), Expect = 2.8
 Identities = 27/90 (30%), Positives = 36/90 (40%), Gaps = 16/90 (17%)

Query: 62   GDGTLAQPSTSSQGPKGE----------GDRGGGPAEGSAGPPAA---LPQQTATPETSV 108
            GD  L+  S+  +   G           G  G  P     G PAA    PQQ   P  +V
Sbjct: 4796 GDADLSHTSSDDESRAGTPSLVTYLKKAGRPGTSPLASKVGAPAAPSVKPQQQQEPLAAV 4855

Query: 109  KKPKAEQGASGSQDPGKPRVGKKAAEGQAA 138
            + P    G   ++D G P + K A + QAA
Sbjct: 4856 RPP---LGDLSTKDLGDPSMDKAAVKIQAA 4882



 Score = 29.6 bits (65), Expect = 8.2
 Identities = 43/190 (22%), Positives = 60/190 (31%), Gaps = 10/190 (5%)

Query: 2    ATENGAVELGIQNPSTDKAPKGPTGERPLAAGKDPGPPDPKKAPDPPTLKKDAKAPASEK 61
            A   GA    + +P   K      G    A  + P P  P   P P    K   AP    
Sbjct: 6988 APSGGAPIRDMGHPQGSKQLPSTGGHPGTAQPERPSPDSPWGQPAPFCHPKQGSAPQEGC 7047

Query: 62   GDGTLAQPSTSSQGPKGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGSQ 121
                   P      P G       P   S+ P    PQ    P  +     ++ G     
Sbjct: 7048 SPHPAVAPCPPGSFPPGSCKEA--PLVPSS-PFLGQPQAPPAPAKASPPLDSKMGPGDIS 7104

Query: 122  DPGKPRVGKKAAEGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEGVPM 181
             PG+P+ G  ++ G A+    S            + SS+      P  +A   T E   +
Sbjct: 7105 LPGRPKPGPCSSPGSASQASSSQV------SSLRVGSSQVGTEPGPSLDAEGWTQEAEDL 7158

Query: 182  THS-PTDPRP 190
            + S PT  RP
Sbjct: 7159 SDSTPTLQRP 7168


>gi|157785645 SPEG complex locus [Homo sapiens]
          Length = 3267

 Score =  174 bits (441), Expect = 2e-43
 Identities = 102/289 (35%), Positives = 167/289 (57%), Gaps = 12/289 (4%)

Query: 289  EALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAA 348
            + +G G F  +   +E+++GL+ AAK I  Q  K K     E  ++ +L H  ++  + A
Sbjct: 1605 QEIGRGAFSYLRRIVERSSGLEFAAKFIPSQA-KPKASARREARLLARLQHDCVLYFHEA 1663

Query: 349  IETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLK 408
             E    +V+  E     EL ERI  +   + E +   ++RQ+ +GI ++H+  VLHLD+K
Sbjct: 1664 FERRRGLVIVTELCTE-ELLERIARKPT-VCESEIRAYMRQVLEGIHYLHQSHVLHLDVK 1721

Query: 409  PENILCVNTTG--HLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMW 466
            PEN+L  +       V+I DFG A+   P E     +GTPEF++PE+VN   +S  TD+W
Sbjct: 1722 PENLLVWDGAAGEQQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIW 1781

Query: 467  SMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQR 526
             +GV+ ++ L+G+SPF+G++D  TL N+ + N  F+E TF ++S EA+ F+  ++V+D R
Sbjct: 1782 PVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-R 1840

Query: 527  ARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIA 575
             R  A + L HPW    A+ A+       S   LK +L +RRW+++ I+
Sbjct: 1841 LRPTAEETLEHPWFKTQAKGAE------VSTDHLKLFLSRRRWQRSQIS 1883



 Score =  163 bits (412), Expect = 5e-40
 Identities = 147/508 (28%), Positives = 223/508 (43%), Gaps = 38/508 (7%)

Query: 103  TPETSVKKPKAEQGASGSQDPGK---PRVGKKAAEGQAAARRGSPAFLHSPSCPAIISSS 159
            T ++S     A Q A  +  P +   P      A   A A    P+   SPS P    S 
Sbjct: 2771 TQDSSAVPSAAHQEAPVTSRPARARPPDSPTSLAPPLAPAAPTPPSVTVSPSSPPTPPSQ 2830

Query: 160  --EKLLAKKPPSEASELTFEGV----------PMTH-SPTDPRPAKAEEGKNILAESQ-- 204
                L A  PP +       G+          P TH +P++P+P   + G  I A +   
Sbjct: 2831 ALSSLKAVGPPPQTPPRRHRGLQAARPAEPTLPSTHVTPSEPKPFVLDTGTPIPASTPQG 2890

Query: 205  -KEVGEKTPGQAGQAKMQGDTSRGIEFQAVPSEKSEVGQALCLTAREEDCFQILDDCPPP 263
             K V   TP     + +    +        P E ++V       A+E           P 
Sbjct: 2891 VKPVSSSTPVYVVTSFVSAPPAPEPPAPEPPPEPTKVTVQSLSPAKE---VVSSPGSSPR 2947

Query: 264  PAPFPHRMVELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKD 323
             +P P     LR G     ++   ++A G  +FG V  C E ATG    AK++     + 
Sbjct: 2948 SSPRPEGTT-LRQGPPQKPYTFLEEKARG--RFGVVRACRENATGRTFVAKIVP-YAAEG 3003

Query: 324  KEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDT 383
            K  VL E EV+  L+H  ++ L+ A  TP  +VL  E     EL   + D  +  +E D 
Sbjct: 3004 KRRVLQEYEVLRTLHHERIMSLHEAYITPRYLVLIAESCGNRELLCGLSDR-FRYSEDDV 3062

Query: 384  MVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPN--EKLKV 441
              ++ Q+  G+ ++H   VLHLD+KP+N+L      + +KI+DFG A+ YNP     L  
Sbjct: 3063 ATYMVQLLQGLDYLHGHHVLHLDIKPDNLLLA--PDNALKIVDFGSAQPYNPQALRPLGH 3120

Query: 442  NFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYF 501
              GT EF++PE+V  + I   TD+W  GV+TY++LSG SPF   D  ET   ++ G   F
Sbjct: 3121 RTGTLEFMAPEMVKGEPIGSATDIWGAGVLTYIMLSGRSPFYEPDPQETEARIVGGR--F 3178

Query: 502  DE-ETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILL 560
            D  + +   S  A  F+  ++     +R +   CLAHPWL +      R      +   L
Sbjct: 3179 DAFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWLQDAYLMKLRRQTLTFTTNRL 3238

Query: 561  KKYLMKRRWKKNFIAVSAANRFKKISSS 588
            K++L ++R ++      AA R K +  S
Sbjct: 3239 KEFLGEQRRRR----AEAATRHKVLLRS 3262



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 39/155 (25%), Positives = 66/155 (42%), Gaps = 20/155 (12%)

Query: 69   PSTSSQGPKGEGDRGGGPAEGSAGPPAALPQQTATP----ETSVKKPKAEQ---GASGSQ 121
            P+  ++G  GE   GG  A GS  P  A+ ++ +       + +++  + +   GASG  
Sbjct: 2427 PAWEARGGDGESSEGGSSARGS--PVLAMRRRLSFTLERLSSRLQRSGSSEDSGGASGRS 2484

Query: 122  DPGKPRVGKKAAEGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEGVP- 180
             P   R+ +  +EG++  R G P    +    A   S+E L      SEAS  +    P 
Sbjct: 2485 TPLFGRLRRATSEGESLRRLGLPHNQLAAQAGATTPSAESL-----GSEASATSGSSAPG 2539

Query: 181  -----MTHSPTDPRPAKAEEGKNILAESQKEVGEK 210
                 +    + PR  K     N+ A  Q+E+G +
Sbjct: 2540 ESRSRLRWGFSRPRKDKGLSPPNLSASVQEELGHQ 2574



 Score = 34.7 bits (78), Expect = 0.26
 Identities = 52/230 (22%), Positives = 82/230 (35%), Gaps = 38/230 (16%)

Query: 15   PSTDKAPKGPTGERPLAAGKDPGPPDPKKAP-DPPTLKKDAKAPASEKGDGTLAQPSTSS 73
            P+  + P  PT   P  A   P PP    +P  PPT                   PS + 
Sbjct: 2791 PARARPPDSPTSLAPPLAPAAPTPPSVTVSPSSPPT------------------PPSQAL 2832

Query: 74   QGPKGEGDRGGGPAEGSAGPPAALPQQTATPETSV--KKPKAEQGASGSQDPGKPRVGKK 131
               K  G     P     G  AA P +   P T V   +PK     +G+  P     G K
Sbjct: 2833 SSLKAVGPPPQTPPRRHRGLQAARPAEPTLPSTHVTPSEPKPFVLDTGTPIPASTPQGVK 2892

Query: 132  AAEGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEGV----PMTHSP-T 186
                       + +F+ +P  P       +  A +PP E +++T + +     +  SP +
Sbjct: 2893 PVSSSTPVYVVT-SFVSAPPAP-------EPPAPEPPPEPTKVTVQSLSPAKEVVSSPGS 2944

Query: 187  DPRPAKAEEGKNILAESQKE----VGEKTPGQAGQAKMQGDTSRGIEFQA 232
             PR +   EG  +     ++    + EK  G+ G  +   + + G  F A
Sbjct: 2945 SPRSSPRPEGTTLRQGPPQKPYTFLEEKARGRFGVVRACRENATGRTFVA 2994



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 56/255 (21%), Positives = 79/255 (30%), Gaps = 50/255 (19%)

Query: 63   DGTLAQPSTSSQGPKGEGDRGGGPAEGSAGP-PAALPQQTATPETSVKKPKAEQGASGSQ 121
            D  L  P T +  P    ++G  P++    P P ALP     P       + E     S 
Sbjct: 1957 DEALGTPETGAATPMDWQEQGRAPSQDQEAPSPEALPSPGQEPAAGASPRRGELRRGSSA 2016

Query: 122  DPGKPRVG--------KKAAEGQAAARRG-SPAF-------LHSPSCPAIISSSEKLLAK 165
            +   PR G         KAA  +   RR  SP         L        + +  + L +
Sbjct: 2017 ESALPRAGPRELGRGLHKAASVELPQRRSPSPGATRLARGGLGEGEYAQRLQALRQRLLR 2076

Query: 166  KPPSEASELTFEGVPMTHS----PTDPRPAKAE------------EGKNILAESQKEVGE 209
              P +       G P+  S      DPR A+A             E + +   S    GE
Sbjct: 2077 GGPEDGKVSGLRG-PLLESLGGRARDPRMARAASSEAAPHHQPPLENRGLQKSSSFSQGE 2135

Query: 210  KTP---------------GQAGQAKMQGDTSRGIEFQAVPSEKSEVGQALCLTARE-EDC 253
              P                + G  ++Q   S     +A PS  +        T +  E  
Sbjct: 2136 AEPRGRHRRAGAPLEIPVARLGARRLQESPSLSALSEAQPSSPARPSAPKPSTPKSAEPS 2195

Query: 254  FQILDDCPPPPAPFP 268
                 D P PPAP P
Sbjct: 2196 ATTPSDAPQPPAPQP 2210



 Score = 29.6 bits (65), Expect = 8.2
 Identities = 21/65 (32%), Positives = 28/65 (43%), Gaps = 4/65 (6%)

Query: 39  PDPKKAPDPPTLKKDAKAPASEKGDGTLAQPSTSSQGPKGEGDRGGGP-AEGSAG--PPA 95
           P P++  +PP   + +    S       AQP + S   K  GD  G P + G AG   P 
Sbjct: 525 PSPREPGEPPLFSRPSTPKTSRAVSPAAAQPPSPSSAEK-PGDEPGRPRSRGPAGRTEPG 583

Query: 96  ALPQQ 100
             PQQ
Sbjct: 584 EGPQQ 588



 Score = 29.6 bits (65), Expect = 8.2
 Identities = 30/99 (30%), Positives = 42/99 (42%), Gaps = 14/99 (14%)

Query: 30   LAAGKDPGPPDPKKAPDPPTLKKDAKAPASEKGDGTLAQPSTSSQGPKGEGDRGGGP--- 86
            ++A   P PP P+  P+P  +   + +PA E      + P  SS  P+G   R G P   
Sbjct: 2907 VSAPPAPEPPAPEPPPEPTKVTVQSLSPAKEVVSSPGSSP-RSSPRPEGTTLRQGPPQKP 2965

Query: 87   -------AEGSAGPPAALPQQTATPETSVKK--PKAEQG 116
                   A G  G   A  ++ AT  T V K  P A +G
Sbjct: 2966 YTFLEEKARGRFGVVRAC-RENATGRTFVAKIVPYAAEG 3003


>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
           isoform 2 [Homo sapiens]
          Length = 478

 Score =  174 bits (440), Expect = 3e-43
 Identities = 101/297 (34%), Positives = 160/297 (53%), Gaps = 6/297 (2%)

Query: 289 EALGGGKFGAVCTCMEKATGLKLAAKVI--KKQTPKDKEMVLLEIEVMNQLNHRNLIQLY 346
           E LG G F  V  C++   G + AAK+I  KK + +D + +  E  +   L H N+++L+
Sbjct: 17  EELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLH 76

Query: 347 AAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLD 406
            +I       L  + + GGELFE IV  +Y+ +E D    ++QI + +L  H+M V+H D
Sbjct: 77  DSISEEGHHYLIFDLVTGGELFEDIVAREYY-SEADASHCIQQILEAVLHCHQMGVVHRD 135

Query: 407 LKPENILCVNTT-GHLVKIIDFGLARRYNPNEKLKVNF-GTPEFLSPEVVNYDQISDKTD 464
           LKPEN+L  +   G  VK+ DFGLA      ++    F GTP +LSPEV+  D      D
Sbjct: 136 LKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVD 195

Query: 465 MWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKD 524
           +W+ GVI Y+LL G  PF  +D       + +G + F    ++ V+ EAKD ++ ++  +
Sbjct: 196 LWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTIN 255

Query: 525 QRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANR 581
              R+ AA+ L HPW+++ +  A  C  R ++   LKK+  +R+ K   +    A R
Sbjct: 256 PSKRITAAEALKHPWISHRSTVAS-CMHRQETVDCLKKFNARRKLKGAILTTMLATR 311


>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
           isoform 1 [Homo sapiens]
          Length = 489

 Score =  174 bits (440), Expect = 3e-43
 Identities = 101/297 (34%), Positives = 160/297 (53%), Gaps = 6/297 (2%)

Query: 289 EALGGGKFGAVCTCMEKATGLKLAAKVI--KKQTPKDKEMVLLEIEVMNQLNHRNLIQLY 346
           E LG G F  V  C++   G + AAK+I  KK + +D + +  E  +   L H N+++L+
Sbjct: 17  EELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLH 76

Query: 347 AAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLD 406
            +I       L  + + GGELFE IV  +Y+ +E D    ++QI + +L  H+M V+H D
Sbjct: 77  DSISEEGHHYLIFDLVTGGELFEDIVAREYY-SEADASHCIQQILEAVLHCHQMGVVHRD 135

Query: 407 LKPENILCVNTT-GHLVKIIDFGLARRYNPNEKLKVNF-GTPEFLSPEVVNYDQISDKTD 464
           LKPEN+L  +   G  VK+ DFGLA      ++    F GTP +LSPEV+  D      D
Sbjct: 136 LKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVD 195

Query: 465 MWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKD 524
           +W+ GVI Y+LL G  PF  +D       + +G + F    ++ V+ EAKD ++ ++  +
Sbjct: 196 LWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTIN 255

Query: 525 QRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANR 581
              R+ AA+ L HPW+++ +  A  C  R ++   LKK+  +R+ K   +    A R
Sbjct: 256 PSKRITAAEALKHPWISHRSTVAS-CMHRQETVDCLKKFNARRKLKGAILTTMLATR 311


>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
           kinase isoform b [Homo sapiens]
          Length = 360

 Score =  167 bits (424), Expect = 2e-41
 Identities = 97/317 (30%), Positives = 169/317 (53%), Gaps = 8/317 (2%)

Query: 271 MVELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKE-MVLL 329
           +++  T ++SS + +  +E LG G F  V    E+ +   +A K I K+  + KE +V  
Sbjct: 20  LLKKHTEDISSVYEI--RERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVEN 77

Query: 330 EIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQ 389
           EI V+ +++H N++ L    E+P  + L ME + GGELF+RI++   + TE D    V Q
Sbjct: 78  EIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSY-TEKDASHLVGQ 136

Query: 390 ICDGILFMHKMRVLHLDLKPENILCVNT-TGHLVKIIDFGLARRYNPNEKLKVNFGTPEF 448
           +   + ++H + ++H DLKPEN+L         + + DFGL++    N  L    GTP +
Sbjct: 137 VLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGN-MLGTACGTPGY 195

Query: 449 LSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEA 508
           ++PE++         D+W++GVI+Y+LL G  PF  + D E  + +L  ++ FD   ++ 
Sbjct: 196 VAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDD 255

Query: 509 VSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRR 568
           +S+ AKDF+ +L+ +D + R    Q L H W++      +     +  QI  +K   +  
Sbjct: 256 ISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQI--RKNFARTH 313

Query: 569 WKKNFIAVSAANRFKKI 585
           WK+ F A S     +K+
Sbjct: 314 WKRAFNATSFLRHIRKL 330


>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
           kinase isoform a [Homo sapiens]
          Length = 426

 Score =  167 bits (424), Expect = 2e-41
 Identities = 97/317 (30%), Positives = 169/317 (53%), Gaps = 8/317 (2%)

Query: 271 MVELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKE-MVLL 329
           +++  T ++SS + +  +E LG G F  V    E+ +   +A K I K+  + KE +V  
Sbjct: 86  LLKKHTEDISSVYEI--RERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVEN 143

Query: 330 EIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQ 389
           EI V+ +++H N++ L    E+P  + L ME + GGELF+RI++   + TE D    V Q
Sbjct: 144 EIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSY-TEKDASHLVGQ 202

Query: 390 ICDGILFMHKMRVLHLDLKPENILCVNT-TGHLVKIIDFGLARRYNPNEKLKVNFGTPEF 448
           +   + ++H + ++H DLKPEN+L         + + DFGL++    N  L    GTP +
Sbjct: 203 VLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGN-MLGTACGTPGY 261

Query: 449 LSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEA 508
           ++PE++         D+W++GVI+Y+LL G  PF  + D E  + +L  ++ FD   ++ 
Sbjct: 262 VAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDD 321

Query: 509 VSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRR 568
           +S+ AKDF+ +L+ +D + R    Q L H W++      +     +  QI  +K   +  
Sbjct: 322 ISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQI--RKNFARTH 379

Query: 569 WKKNFIAVSAANRFKKI 585
           WK+ F A S     +K+
Sbjct: 380 WKRAFNATSFLRHIRKL 396


>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
          Length = 648

 Score =  167 bits (423), Expect = 3e-41
 Identities = 120/390 (30%), Positives = 191/390 (48%), Gaps = 31/390 (7%)

Query: 164 AKKPPSEASELTFEGVPMTHSPTDPRPAKAEEGKNILAESQKEVGEKTPGQAGQAKMQGD 223
           AKK   E   +T EG+      T P  ++++ G  +L E Q          AG  K++  
Sbjct: 242 AKKDLVEVLPVTEEGLREVKKDTRPM-SRSKHGGWLLREHQ----------AGFEKLR-- 288

Query: 224 TSRGIEFQAVPSEKSEVGQALCLTAREEDCFQIL--------DDCPPPPAPFPHRMVELR 275
            +RG E +A   +K  +     +T R++   ++         ++ P  P+    R + + 
Sbjct: 289 RTRGEEKEAEKEKKPCMSGGRRMTLRDDQPAKLEKEPKTRPEENKPERPSGRKPRPMGII 348

Query: 276 TGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKE-MVLLEIEVM 334
             NV   +       +G G F  V  C  + T    A K+I K   K KE MV  EI ++
Sbjct: 349 AANVEKHYETG--RVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILII 406

Query: 335 NQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGI 394
             L+H N+++L+   ET  EI L +EY++GG+LF+ I+ E     E D  + +  +C  +
Sbjct: 407 QSLSHPNIVKLHEVYETDMEIYLILEYVQGGDLFDAII-ESVKFPEPDAALMIMDLCKAL 465

Query: 395 LFMHKMRVLHLDLKPENILCVNT--TGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPE 452
           + MH   ++H DLKPEN+L          +K+ DFGLA+  +    +    GTP +++PE
Sbjct: 466 VHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAK--HVVRPIFTVCGTPTYVAPE 523

Query: 453 VVNYDQISDKTDMWSMGVITYMLLSGLSPFLGD--DDTETLNNVLSGNWYFDEETFEAVS 510
           +++      + DMW+ GVI Y+LL G  PF     D  E  N +  G++ F    ++ +S
Sbjct: 524 ILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNIS 583

Query: 511 DEAKDFVSNLIVKDQRARMNAAQCLAHPWL 540
           D AKD VS L+V D + R  A Q L HPW+
Sbjct: 584 DAAKDLVSRLLVVDPKKRYTAHQVLQHPWI 613


>gi|14916455 protein serine kinase H2 [Homo sapiens]
          Length = 385

 Score =  167 bits (423), Expect = 3e-41
 Identities = 94/280 (33%), Positives = 160/280 (57%), Gaps = 7/280 (2%)

Query: 288 KEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYA 347
           K  +G G F  V    +K T    A KV++ +  + +E  + E+ V+ +++HR ++QL  
Sbjct: 66  KALIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGREACVSELSVLRRVSHRYIVQLME 125

Query: 348 AIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDL 407
             ET  ++ + ME   GGELF+R++ +    TE D +  ++ + DGI ++H +++ H +L
Sbjct: 126 IFETEDQVYMVMELATGGELFDRLIAQG-SFTERDAVRILQMVADGIRYLHALQITHRNL 184

Query: 408 KPENILCVNTTGHLVKII--DFGLAR--RYNPNEKLKVNFGTPEFLSPEVVNYDQISDKT 463
           KPEN+L  +  G   KI+  DFGLA   + + +  +K   GTPE+++PEV+     +   
Sbjct: 185 KPENLLYYHP-GEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAV 243

Query: 464 DMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVK 523
           DMW++GVITY LLSG  PF  +  T     +L G + +  E + ++S  AKDF+  L++ 
Sbjct: 244 DMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISHLAKDFIDKLLIL 303

Query: 524 DQRARMNAAQCLAHPWLNNLAEKAKRCN-RRLKSQILLKK 562
           +   RM+A Q L HPW+  +A  +   N +R  S+ L+++
Sbjct: 304 EAGHRMSAGQALDHPWVITMAAGSSMKNLQRAISRNLMQR 343


>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
           sapiens]
          Length = 476

 Score =  166 bits (420), Expect = 6e-41
 Identities = 94/312 (30%), Positives = 162/312 (51%), Gaps = 7/312 (2%)

Query: 275 RTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVM 334
           +T N+   F     E LG G F  V    ++ TG   A K IKK        +  EI V+
Sbjct: 15  QTTNIRKTFIF--MEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVL 72

Query: 335 NQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGI 394
            ++ H N++ L    E+     L M+ + GGELF+RI++   + TE D  + ++Q+   +
Sbjct: 73  KKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVY-TEKDASLVIQQVLSAV 131

Query: 395 LFMHKMRVLHLDLKPENILCVNTTGHL-VKIIDFGLARRYNPNEKLKVNFGTPEFLSPEV 453
            ++H+  ++H DLKPEN+L +    +  + I DFGL++    N  +    GTP +++PEV
Sbjct: 132 KYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKM-EQNGIMSTACGTPGYVAPEV 190

Query: 454 VNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEA 513
           +     S   D WS+GVITY+LL G  PF  + +++    +  G + F+   ++ +S+ A
Sbjct: 191 LAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESA 250

Query: 514 KDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNF 573
           KDF+ +L+ KD   R    + L+HPW++      +     +  QI  +K   K +W++ F
Sbjct: 251 KDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQI--QKNFAKSKWRQAF 308

Query: 574 IAVSAANRFKKI 585
            A +  +  +K+
Sbjct: 309 NAAAVVHHMRKL 320


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.131    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,531,503
Number of Sequences: 37866
Number of extensions: 1503580
Number of successful extensions: 15048
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 671
Number of HSP's successfully gapped in prelim test: 1306
Number of HSP's that attempted gapping in prelim test: 8104
Number of HSP's gapped (non-prelim): 4847
length of query: 596
length of database: 18,247,518
effective HSP length: 108
effective length of query: 488
effective length of database: 14,157,990
effective search space: 6909099120
effective search space used: 6909099120
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.