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Search of human proteins with 149408126
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|149408126 nemo like kinase [Homo sapiens]
(527 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|149408126 nemo like kinase [Homo sapiens] 1087 0.0
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 281 1e-75
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 281 1e-75
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 281 1e-75
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 254 1e-67
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 254 1e-67
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 248 7e-66
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 247 2e-65
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 246 5e-65
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ... 244 1e-64
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s... 236 5e-62
gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ... 228 1e-59
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 224 2e-58
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 220 2e-57
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ... 220 3e-57
gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ... 219 5e-57
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 217 2e-56
gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta... 211 2e-54
gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta... 211 2e-54
gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s... 210 3e-54
gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ... 210 3e-54
gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ... 210 3e-54
gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph... 209 5e-54
gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph... 209 5e-54
gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo s... 206 3e-53
gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph... 204 1e-52
gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha... 204 1e-52
gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta... 203 4e-52
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta... 203 4e-52
gi|4506091 mitogen-activated protein kinase 6 [Homo sapiens] 194 1e-49
>gi|149408126 nemo like kinase [Homo sapiens]
Length = 527
Score = 1087 bits (2812), Expect = 0.0
Identities = 527/527 (100%), Positives = 527/527 (100%)
Query: 1 MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAA 60
MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAA
Sbjct: 1 MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAA 60
Query: 61 VHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAAT 120
VHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAAT
Sbjct: 61 VHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAAT 120
Query: 121 VKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK 180
VKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK
Sbjct: 121 VKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK 180
Query: 181 RVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDH 240
RVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDH
Sbjct: 181 RVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDH 240
Query: 241 VKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQE 300
VKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQE
Sbjct: 241 VKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQE 300
Query: 301 VVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTP 360
VVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTP
Sbjct: 301 VVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTP 360
Query: 361 SLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKD 420
SLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKD
Sbjct: 361 SLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKD 420
Query: 421 ALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEI 480
ALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEI
Sbjct: 421 ALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEI 480
Query: 481 IHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE 527
IHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE
Sbjct: 481 IHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE 527
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 281 bits (719), Expect = 1e-75
Identities = 170/391 (43%), Positives = 234/391 (59%), Gaps = 35/391 (8%)
Query: 101 QAPGPAAAAPAQVQAAAAAT----VKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVT 156
+ PGP A PA A+ AA +KA + + +I IG GA+GVV S
Sbjct: 16 EPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEII--ETIGNGAYGVVSSAR 73
Query: 157 DPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDY--FEE 214
G++VA+KK+PN F + + KR RELK+L FKHDN+++ DIL+P + Y F+
Sbjct: 74 RRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPT-VPYGEFKS 132
Query: 215 IYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNS 274
+YVV +LM+SDLH+II S QPL+ +HV+ FLYQ+LRGLKY+HSA ++HRD+KP NLLVN
Sbjct: 133 VYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNE 192
Query: 275 NCVLKICDFGLAR---VEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIF 331
NC LKI DFG+AR + MT+ V T++YRAPE+++ Y+ AID+WSVGCIF
Sbjct: 193 NCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIF 252
Query: 332 AELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMR-TACEGAKAHILRGPHKQPSLPVLY 390
E+L RR LF ++ + QL LI +LGTPS ++ E +A+I P +QP +P
Sbjct: 253 GEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQP-VP-WE 310
Query: 391 TLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRV 450
T+ A +A+ LL RML F+PS RISA AL HP+L +YH
Sbjct: 311 TVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL----AKYH--------------- 351
Query: 451 YTSDFEPVTNPKFDDTFEKNLSSVRQVKEII 481
D EP P FD F++ + ++KE I
Sbjct: 352 -DPDDEPDCAPPFDFAFDREALTRERIKEAI 381
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 281 bits (719), Expect = 1e-75
Identities = 170/391 (43%), Positives = 234/391 (59%), Gaps = 35/391 (8%)
Query: 101 QAPGPAAAAPAQVQAAAAAT----VKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVT 156
+ PGP A PA A+ AA +KA + + +I IG GA+GVV S
Sbjct: 16 EPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEII--ETIGNGAYGVVSSAR 73
Query: 157 DPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDY--FEE 214
G++VA+KK+PN F + + KR RELK+L FKHDN+++ DIL+P + Y F+
Sbjct: 74 RRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPT-VPYGEFKS 132
Query: 215 IYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNS 274
+YVV +LM+SDLH+II S QPL+ +HV+ FLYQ+LRGLKY+HSA ++HRD+KP NLLVN
Sbjct: 133 VYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNE 192
Query: 275 NCVLKICDFGLAR---VEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIF 331
NC LKI DFG+AR + MT+ V T++YRAPE+++ Y+ AID+WSVGCIF
Sbjct: 193 NCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIF 252
Query: 332 AELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMR-TACEGAKAHILRGPHKQPSLPVLY 390
E+L RR LF ++ + QL LI +LGTPS ++ E +A+I P +QP +P
Sbjct: 253 GEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQP-VP-WE 310
Query: 391 TLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRV 450
T+ A +A+ LL RML F+PS RISA AL HP+L +YH
Sbjct: 311 TVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL----AKYH--------------- 351
Query: 451 YTSDFEPVTNPKFDDTFEKNLSSVRQVKEII 481
D EP P FD F++ + ++KE I
Sbjct: 352 -DPDDEPDCAPPFDFAFDREALTRERIKEAI 381
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 281 bits (719), Expect = 1e-75
Identities = 170/391 (43%), Positives = 234/391 (59%), Gaps = 35/391 (8%)
Query: 101 QAPGPAAAAPAQVQAAAAAT----VKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVT 156
+ PGP A PA A+ AA +KA + + +I IG GA+GVV S
Sbjct: 16 EPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEII--ETIGNGAYGVVSSAR 73
Query: 157 DPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDY--FEE 214
G++VA+KK+PN F + + KR RELK+L FKHDN+++ DIL+P + Y F+
Sbjct: 74 RRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPT-VPYGEFKS 132
Query: 215 IYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNS 274
+YVV +LM+SDLH+II S QPL+ +HV+ FLYQ+LRGLKY+HSA ++HRD+KP NLLVN
Sbjct: 133 VYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNE 192
Query: 275 NCVLKICDFGLAR---VEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIF 331
NC LKI DFG+AR + MT+ V T++YRAPE+++ Y+ AID+WSVGCIF
Sbjct: 193 NCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIF 252
Query: 332 AELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMR-TACEGAKAHILRGPHKQPSLPVLY 390
E+L RR LF ++ + QL LI +LGTPS ++ E +A+I P +QP +P
Sbjct: 253 GEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQP-VP-WE 310
Query: 391 TLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRV 450
T+ A +A+ LL RML F+PS RISA AL HP+L +YH
Sbjct: 311 TVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL----AKYH--------------- 351
Query: 451 YTSDFEPVTNPKFDDTFEKNLSSVRQVKEII 481
D EP P FD F++ + ++KE I
Sbjct: 352 -DPDDEPDCAPPFDFAFDREALTRERIKEAI 381
>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 254 bits (649), Expect = 1e-67
Identities = 145/353 (41%), Positives = 216/353 (61%), Gaps = 27/353 (7%)
Query: 144 IGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDI 203
IG GA+G+V S D + RVA+KK+ + F++ C+R RE+K+L F+H+N++ DI
Sbjct: 31 IGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFRHENIIGINDI 89
Query: 204 LQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHR 263
++ P I+ +++Y+V +LM++DL+K++ + Q LS+DH+ FLYQILRGLKY+HSA +LHR
Sbjct: 90 IRAPTIEQMKDVYIVQDLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHR 148
Query: 264 DIKPGNLLVNSNCVLKICDFGLARVEELDESR--HMTQEVVTQYYRAPEILMGSRHYSNA 321
D+KP NLL+N+ C LKICDFGLARV + D +T+ V T++YRAPEI++ S+ Y+ +
Sbjct: 149 DLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS 208
Query: 322 IDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACE-GAKAHILRGP 380
IDIWSVGCI AE+L R +F + + QL+ I +LG+PS E + A+ ++L P
Sbjct: 209 IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLP 268
Query: 381 HKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCK 440
HK +P L A +A+ LL +ML F+P KRI + ALAHPYL++
Sbjct: 269 HKN-KVP-WNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ----------- 315
Query: 441 CCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNR 493
Y EP+ F E + ++KE+I + Q G R
Sbjct: 316 ---------YYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYR 359
>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 254 bits (649), Expect = 1e-67
Identities = 145/353 (41%), Positives = 216/353 (61%), Gaps = 27/353 (7%)
Query: 144 IGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDI 203
IG GA+G+V S D + RVA+KK+ + F++ C+R RE+K+L F+H+N++ DI
Sbjct: 31 IGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFRHENIIGINDI 89
Query: 204 LQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHR 263
++ P I+ +++Y+V +LM++DL+K++ + Q LS+DH+ FLYQILRGLKY+HSA +LHR
Sbjct: 90 IRAPTIEQMKDVYIVQDLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHR 148
Query: 264 DIKPGNLLVNSNCVLKICDFGLARVEELDESR--HMTQEVVTQYYRAPEILMGSRHYSNA 321
D+KP NLL+N+ C LKICDFGLARV + D +T+ V T++YRAPEI++ S+ Y+ +
Sbjct: 149 DLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS 208
Query: 322 IDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACE-GAKAHILRGP 380
IDIWSVGCI AE+L R +F + + QL+ I +LG+PS E + A+ ++L P
Sbjct: 209 IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLP 268
Query: 381 HKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCK 440
HK +P L A +A+ LL +ML F+P KRI + ALAHPYL++
Sbjct: 269 HKN-KVP-WNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ----------- 315
Query: 441 CCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNR 493
Y EP+ F E + ++KE+I + Q G R
Sbjct: 316 ---------YYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYR 359
>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
sapiens]
Length = 379
Score = 248 bits (634), Expect = 7e-66
Identities = 141/350 (40%), Positives = 212/350 (60%), Gaps = 25/350 (7%)
Query: 144 IGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDI 203
IG GA+G+V S D RVA+KK+ + F++ C+R RE+++L F+H+NV+ DI
Sbjct: 48 IGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFRHENVIGIRDI 106
Query: 204 LQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHR 263
L+ ++ ++Y+V +LM++DL+K++ S Q LS+DH+ FLYQILRGLKY+HSA +LHR
Sbjct: 107 LRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANVLHR 165
Query: 264 DIKPGNLLVNSNCVLKICDFGLARV--EELDESRHMTQEVVTQYYRAPEILMGSRHYSNA 321
D+KP NLL+N+ C LKICDFGLAR+ E D + +T+ V T++YRAPEI++ S+ Y+ +
Sbjct: 166 DLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS 225
Query: 322 IDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPH 381
IDIWSVGCI AE+L R +F + + QL+ I +LG+PS E + + L+
Sbjct: 226 IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLP 285
Query: 382 KQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKC 441
+ + L ++ +A+ LL RML F+P+KRI+ ++ALAHPYL++
Sbjct: 286 SKTKV-AWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ------------ 332
Query: 442 CFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKG 491
Y EPV F E + ++KE+I Q Q G
Sbjct: 333 --------YYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPG 374
>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
sapiens]
Length = 357
Score = 247 bits (630), Expect = 2e-65
Identities = 129/288 (44%), Positives = 196/288 (68%), Gaps = 5/288 (1%)
Query: 144 IGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDI 203
IG GA+G+V S D RVA+KK+ + F++ C+R RE+++L F+H+NV+ DI
Sbjct: 48 IGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFRHENVIGIRDI 106
Query: 204 LQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHR 263
L+ ++ ++Y+V +LM++DL+K++ S Q LS+DH+ FLYQILRGLKY+HSA +LHR
Sbjct: 107 LRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANVLHR 165
Query: 264 DIKPGNLLVNSNCVLKICDFGLARV--EELDESRHMTQEVVTQYYRAPEILMGSRHYSNA 321
D+KP NLL+N+ C LKICDFGLAR+ E D + +T+ V T++YRAPEI++ S+ Y+ +
Sbjct: 166 DLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS 225
Query: 322 IDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPH 381
IDIWSVGCI AE+L R +F + + QL+ I +LG+PS E + + L+
Sbjct: 226 IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLP 285
Query: 382 KQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDE 429
+ + L ++ +A+ LL RML F+P+KRI+ ++ALAHPYL++
Sbjct: 286 SKTKV-AWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332
>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
Length = 364
Score = 246 bits (627), Expect = 5e-65
Identities = 147/349 (42%), Positives = 211/349 (60%), Gaps = 34/349 (9%)
Query: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
RP+G GA+G V S D R ++VA+KK+ FQ+L+ +R +REL++L KH+NV+ L
Sbjct: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 87
Query: 202 DILQPP-HIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
D+ P I+ F E+Y+VT LM +DL+ I V Q LS +HV+ +YQ+LRGLKY+HSAGI
Sbjct: 88 DVFTPATSIEDFSEVYLVTTLMGADLNNI-VKCQALSDEHVQFLVYQLLRGLKYIHSAGI 146
Query: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320
+HRD+KP N+ VN +C L+I DFGLAR + DE MT V T++YRAPEI++ HY+
Sbjct: 147 IHRDLKPSNVAVNEDCELRILDFGLAR--QADE--EMTGYVATRWYRAPEIMLNWMHYNQ 202
Query: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAM-RTACEGAKAHILRG 379
+DIWSVGCI AELL + LF I QL I +++GTPS E + + + E A+ +I
Sbjct: 203 TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI--- 259
Query: 380 PHKQPSLPV--LYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTC 437
P +P L ++ A A+ LL RMLV D +R+SA +ALAH Y + YH
Sbjct: 260 -QSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ----YH-- 312
Query: 438 MCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFIL 486
+ EP P +D++ E ++ + KE+ +Q +L
Sbjct: 313 --------------DPEDEPEAEP-YDESVEAKERTLEEWKELTYQEVL 346
>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
sapiens]
Length = 360
Score = 244 bits (623), Expect = 1e-64
Identities = 144/345 (41%), Positives = 201/345 (58%), Gaps = 28/345 (8%)
Query: 143 PIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALD 202
P+G GA+G V + D + G RVA+KK+ FQ+++ KR +REL++L KH+NV+ LD
Sbjct: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88
Query: 203 ILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGIL 261
+ P ++ F ++Y+VT LM +DL+ I V Q L+ DHV+ +YQILRGLKY+HSA I+
Sbjct: 89 VFTPARSLEEFNDVYLVTHLMGADLNNI-VKCQKLTDDHVQFLIYQILRGLKYIHSADII 147
Query: 262 HRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNA 321
HRD+KP NL VN +C LKI DFGLAR + DE MT V T++YRAPEI++ HY+
Sbjct: 148 HRDLKPSNLAVNEDCELKILDFGLARHTD-DE---MTGYVATRWYRAPEIMLNWMHYNQT 203
Query: 322 IDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPH 381
+DIWSVGCI AELL R LF I QL LI L+GTP E ++ + + ++
Sbjct: 204 VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLT 263
Query: 382 KQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKC 441
+ P + A AV LL +MLV D KRI+A ALAH Y +YH
Sbjct: 264 QMPKMNFANVFIG-ANPLAVDLLEKMLVLDSDKRITAAQALAHAYF----AQYH------ 312
Query: 442 CFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFIL 486
D EPV +P +D +FE + + K + + ++
Sbjct: 313 ----------DPDDEPVADP-YDQSFESRDLLIDEWKSLTYDEVI 346
>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
sapiens]
Length = 360
Score = 236 bits (601), Expect = 5e-62
Identities = 142/345 (41%), Positives = 196/345 (56%), Gaps = 28/345 (8%)
Query: 143 PIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALD 202
P+G GA+G V + D + G RVA+KK+ FQ+++ KR +REL++L KH+NV+ LD
Sbjct: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88
Query: 203 ILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGIL 261
+ P ++ F ++Y+VT LM +DL+ I V Q L+ DHV+ +YQILRGLKY+HSA I+
Sbjct: 89 VFTPARSLEEFNDVYLVTHLMGADLNNI-VKCQKLTDDHVQFLIYQILRGLKYIHSADII 147
Query: 262 HRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNA 321
HRD+KP NL VN +C LKI DFGLAR + DE MT V T++YRAPEI++ HY+
Sbjct: 148 HRDLKPSNLAVNEDCELKILDFGLARHTD-DE---MTGYVATRWYRAPEIMLNWMHYNQT 203
Query: 322 IDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPH 381
+DIWSVGCI AELL R LF I QL I L GTP + + ++
Sbjct: 204 VDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHEARNYIQSLT 263
Query: 382 KQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKC 441
+ P + A AV LL +MLV D KRI+A ALAH Y +YH
Sbjct: 264 QMPKMNFANVFIG-ANPLAVDLLEKMLVLDSDKRITAAQALAHAYF----AQYH------ 312
Query: 442 CFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFIL 486
D EPV +P +D +FE + + K + + ++
Sbjct: 313 ----------DPDDEPVADP-YDQSFESRDLLIDEWKSLTYDEVI 346
>gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo
sapiens]
Length = 335
Score = 228 bits (580), Expect = 1e-59
Identities = 136/350 (38%), Positives = 197/350 (56%), Gaps = 69/350 (19%)
Query: 144 IGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDI 203
IG GA+G+V S D RVA+KK+ + F++ C+R RE+++L F+H+NV+ DI
Sbjct: 48 IGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFRHENVIGIRDI 106
Query: 204 LQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHR 263
L+ ++ ++Y+V +LM++DL+K++ S Q LS+DH+ FLYQILRGLKY+HSA +LHR
Sbjct: 107 LRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANVLHR 165
Query: 264 DIKPGNLLVNSNCVLKICDFGLARV--EELDESRHMTQEVVTQYYRAPEILMGSRHYSNA 321
D+KP NLL+N+ C LKICDFGLAR+ E D + +T+ V T++YRAPEI++ S+ Y+ +
Sbjct: 166 DLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS 225
Query: 322 IDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPH 381
IDIWSVGCI AE+L R +F + + QL+ HIL
Sbjct: 226 IDIWSVGCILAEMLSNRPIFPGKHYLDQLN-----------------------HIL---- 258
Query: 382 KQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKC 441
A+ LL RML F+P+KRI+ ++ALAHPYL++
Sbjct: 259 ------------------ALDLLDRMLTFNPNKRITVEEALAHPYLEQ------------ 288
Query: 442 CFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKG 491
Y EPV F E + ++KE+I Q Q G
Sbjct: 289 --------YYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPG 330
>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
Length = 367
Score = 224 bits (571), Expect = 2e-58
Identities = 131/359 (36%), Positives = 209/359 (58%), Gaps = 34/359 (9%)
Query: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
+P+G GA+G V S D R G +VA+KK+ FQ+ + KR +REL++L +H+NV+ L
Sbjct: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90
Query: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
D+ P +D F + Y+V M +DL K++ + L D ++ +YQ+L+GL+Y+H+AGI
Sbjct: 91 DVFTPDETLDDFTDFYLVMPFMGTDLGKLM-KHEKLGEDRIQFLVYQMLKGLRYIHAAGI 149
Query: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320
+HRD+KPGNL VN +C LKI DFGLAR + + MT VVT++YRAPE+++ Y+
Sbjct: 150 IHRDLKPGNLAVNEDCELKILDFGLARQADSE----MTGYVVTRWYRAPEVILNWMRYTQ 205
Query: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLE-AMRTACEGAKAHILRG 379
+DIWSVGCI AE++ + LF+ + QL I + GTP E R + AK ++
Sbjct: 206 TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGL 265
Query: 380 PHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMC 439
P + ++ + A+ AV+LL +MLV D +R++A +ALAHPY +
Sbjct: 266 PELEKK--DFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES---------- 313
Query: 440 KCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILE----QQKGNRV 494
++ ++ EP K+DD+F+ ++ + K + ++ +L +Q G RV
Sbjct: 314 ----------LHDTEDEPQVQ-KYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARV 361
>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
Length = 544
Score = 220 bits (561), Expect = 2e-57
Identities = 118/299 (39%), Positives = 181/299 (60%), Gaps = 12/299 (4%)
Query: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFF-KHDNVLSA 200
R +G GA+G+VW D R G+ VA+KK+ + F++ +R FRE+ +L F H N++S
Sbjct: 17 RQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISL 76
Query: 201 LDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
LD+++ + +IY+V E M +DL+ +I L HV+ YQ+LR ++LHS +
Sbjct: 77 LDVIRAEND---RDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHV 133
Query: 261 LHRDIKPGNLLVNSNCVLKICDFGLAR----VEELDESRHMTQEVVTQYYRAPEILMGSR 316
+HRD KP N+L+++NC +K+CDFGLAR + E E + +T+ V T++YRAPE+L+ S
Sbjct: 134 VHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSH 193
Query: 317 HYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHI 376
Y+ +D+WS+GCI E+L R LF S + QL+LI + + PS E + G +A +
Sbjct: 194 RYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASV 253
Query: 377 LRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYH 435
L +P + L + EA+ LL R+LVF P KR+SA AL HPY+ R+H
Sbjct: 254 LHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQ----RFH 308
>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
sapiens]
Length = 297
Score = 220 bits (560), Expect = 3e-57
Identities = 117/236 (49%), Positives = 159/236 (67%), Gaps = 7/236 (2%)
Query: 143 PIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALD 202
P+G GA+G V + D + G RVA+KK+ FQ+++ KR +REL++L KH+NV+ LD
Sbjct: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88
Query: 203 ILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGIL 261
+ P ++ F ++Y+VT LM +DL+ I V Q L+ DHV+ +YQILRGLKY+HSA I+
Sbjct: 89 VFTPARSLEEFNDVYLVTHLMGADLNNI-VKCQKLTDDHVQFLIYQILRGLKYIHSADII 147
Query: 262 HRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNA 321
HRD+KP NL VN +C LKI DFGLAR + DE MT V T++YRAPEI++ HY+
Sbjct: 148 HRDLKPSNLAVNEDCELKILDFGLARHTD-DE---MTGYVATRWYRAPEIMLNWMHYNQT 203
Query: 322 IDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAM-RTACEGAKAHI 376
+DIWSVGCI AELL R LF I QL LI L+GTP E + + + E A+ +I
Sbjct: 204 VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYI 259
>gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo
sapiens]
Length = 307
Score = 219 bits (558), Expect = 5e-57
Identities = 114/225 (50%), Positives = 153/225 (68%), Gaps = 6/225 (2%)
Query: 143 PIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALD 202
P+G GA+G V + D + G RVA+KK+ FQ+++ KR +REL++L KH+NV+ LD
Sbjct: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88
Query: 203 ILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGIL 261
+ P ++ F ++Y+VT LM +DL+ I V Q L+ DHV+ +YQILRGLKY+HSA I+
Sbjct: 89 VFTPARSLEEFNDVYLVTHLMGADLNNI-VKCQKLTDDHVQFLIYQILRGLKYIHSADII 147
Query: 262 HRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNA 321
HRD+KP NL VN +C LKI DFGLAR + DE MT V T++YRAPEI++ HY+
Sbjct: 148 HRDLKPSNLAVNEDCELKILDFGLARHTD-DE---MTGYVATRWYRAPEIMLNWMHYNQT 203
Query: 322 IDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMR 366
+DIWSVGCI AELL R LF I QL LI L+GTP E ++
Sbjct: 204 VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLK 248
>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
Length = 365
Score = 217 bits (553), Expect = 2e-56
Identities = 120/290 (41%), Positives = 177/290 (61%), Gaps = 10/290 (3%)
Query: 144 IGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDI 203
+G GA+G V S D R G++VA+KK+ FQ+ + KR +REL +L +H+NV+ LD+
Sbjct: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90
Query: 204 LQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILH 262
P + F + Y+V MQ+DL KI+ S + ++ +YQ+L+GLKY+HSAG++H
Sbjct: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAGVVH 148
Query: 263 RDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAI 322
RD+KPGNL VN +C LKI DFGLAR + + MT VVT++YRAPE+++ HY+ +
Sbjct: 149 RDLKPGNLAVNEDCELKILDFGLARHADAE----MTGYVVTRWYRAPEVILSWMHYNQTV 204
Query: 323 DIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLE-AMRTACEGAKAHILRGPH 381
DIWSVGCI AE+L + LF+ + + QL I + G P E + + AK++I P
Sbjct: 205 DIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP- 263
Query: 382 KQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGR 431
Q L +A+ +A LL +ML D KR++A AL HP+ + R
Sbjct: 264 -QTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFR 312
>gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2
[Homo sapiens]
Length = 424
Score = 211 bits (536), Expect = 2e-54
Identities = 122/298 (40%), Positives = 180/298 (60%), Gaps = 18/298 (6%)
Query: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
+PIG GA G+V + D G VA+KK+ FQN KR +REL +L H N++S L
Sbjct: 30 KPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLL 89
Query: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
++ P ++ F+++Y+V ELM ++L ++I L + + LYQ+L G+K+LHSAGI
Sbjct: 90 NVFTPQKTLEEFQDVYLVMELMDANLCQVI--HMELDHERMSYLLYQMLCGIKHLHSAGI 147
Query: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320
+HRD+KP N++V S+C LKI DFGLAR + MT VVT+YYRAPE+++G + N
Sbjct: 148 IHRDLKPSNIVVKSDCTLKILDFGLART--ACTNFMMTPYVVTRYYRAPEVILGMGYKEN 205
Query: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380
+DIWSVGCI AE++ ++LF + I Q + + + LGTPS E M+ + ++ P
Sbjct: 206 -VDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRP 264
Query: 381 HKQPSLPV-------LYTLSSQ----ATHEAVHLLCRMLVFDPSKRISAKDALAHPYL 427
K P + ++ S+ T +A LL +MLV DP KRIS +AL HPY+
Sbjct: 265 -KYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI 321
>gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1
[Homo sapiens]
Length = 382
Score = 211 bits (536), Expect = 2e-54
Identities = 122/298 (40%), Positives = 180/298 (60%), Gaps = 18/298 (6%)
Query: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
+PIG GA G+V + D G VA+KK+ FQN KR +REL +L H N++S L
Sbjct: 30 KPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLL 89
Query: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
++ P ++ F+++Y+V ELM ++L ++I L + + LYQ+L G+K+LHSAGI
Sbjct: 90 NVFTPQKTLEEFQDVYLVMELMDANLCQVI--HMELDHERMSYLLYQMLCGIKHLHSAGI 147
Query: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320
+HRD+KP N++V S+C LKI DFGLAR + MT VVT+YYRAPE+++G + N
Sbjct: 148 IHRDLKPSNIVVKSDCTLKILDFGLART--ACTNFMMTPYVVTRYYRAPEVILGMGYKEN 205
Query: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380
+DIWSVGCI AE++ ++LF + I Q + + + LGTPS E M+ + ++ P
Sbjct: 206 -VDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRP 264
Query: 381 HKQPSLPV-------LYTLSSQ----ATHEAVHLLCRMLVFDPSKRISAKDALAHPYL 427
K P + ++ S+ T +A LL +MLV DP KRIS +AL HPY+
Sbjct: 265 -KYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI 321
>gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
sapiens]
Length = 422
Score = 210 bits (534), Expect = 3e-54
Identities = 121/298 (40%), Positives = 181/298 (60%), Gaps = 16/298 (5%)
Query: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
+PIG GA G+V + D + VA+KK+ FQN KR +REL ++ H N++S L
Sbjct: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLL 127
Query: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
++ P ++ F+++Y+V ELM ++L ++I L + + LYQ+L G+K+LHSAGI
Sbjct: 128 NVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGI 185
Query: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320
+HRD+KP N++V S+C LKI DFGLAR S MT VVT+YYRAPE+++G + N
Sbjct: 186 IHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVILGMGYKEN 243
Query: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380
+DIWSVGCI E++ +ILF + I Q + + + LGTP E M+ + ++ P
Sbjct: 244 -VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302
Query: 381 -HKQPSLPVLYTLS---SQATH------EAVHLLCRMLVFDPSKRISAKDALAHPYLD 428
+ + P L+ S + + H +A LL +MLV DP+KRIS DAL HPY++
Sbjct: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360
>gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
sapiens]
Length = 464
Score = 210 bits (534), Expect = 3e-54
Identities = 121/298 (40%), Positives = 181/298 (60%), Gaps = 16/298 (5%)
Query: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
+PIG GA G+V + D + VA+KK+ FQN KR +REL ++ H N++S L
Sbjct: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLL 127
Query: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
++ P ++ F+++Y+V ELM ++L ++I L + + LYQ+L G+K+LHSAGI
Sbjct: 128 NVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGI 185
Query: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320
+HRD+KP N++V S+C LKI DFGLAR S MT VVT+YYRAPE+++G + N
Sbjct: 186 IHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVILGMGYKEN 243
Query: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380
+DIWSVGCI E++ +ILF + I Q + + + LGTP E M+ + ++ P
Sbjct: 244 -VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302
Query: 381 -HKQPSLPVLYTLS---SQATH------EAVHLLCRMLVFDPSKRISAKDALAHPYLD 428
+ + P L+ S + + H +A LL +MLV DP+KRIS DAL HPY++
Sbjct: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360
>gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo
sapiens]
Length = 426
Score = 210 bits (534), Expect = 3e-54
Identities = 121/298 (40%), Positives = 181/298 (60%), Gaps = 16/298 (5%)
Query: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
+PIG GA G+V + D + VA+KK+ FQN KR +REL ++ H N++S L
Sbjct: 30 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLL 89
Query: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
++ P ++ F+++Y+V ELM ++L ++I L + + LYQ+L G+K+LHSAGI
Sbjct: 90 NVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGI 147
Query: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320
+HRD+KP N++V S+C LKI DFGLAR S MT VVT+YYRAPE+++G + N
Sbjct: 148 IHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVILGMGYKEN 205
Query: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380
+DIWSVGCI E++ +ILF + I Q + + + LGTP E M+ + ++ P
Sbjct: 206 -VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 264
Query: 381 -HKQPSLPVLYTLS---SQATH------EAVHLLCRMLVFDPSKRISAKDALAHPYLD 428
+ + P L+ S + + H +A LL +MLV DP+KRIS DAL HPY++
Sbjct: 265 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 322
>gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1
[Homo sapiens]
Length = 382
Score = 209 bits (532), Expect = 5e-54
Identities = 122/298 (40%), Positives = 178/298 (59%), Gaps = 18/298 (6%)
Query: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
+PIG GA G+V + D G VA+KK+ FQN KR +REL +L H N++S L
Sbjct: 30 KPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLL 89
Query: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
++ P ++ F+++Y+V ELM ++L ++I L + + LYQ+L G+K+LHSAGI
Sbjct: 90 NVFTPQKTLEEFQDVYLVMELMDANLCQVI--HMELDHERMSYLLYQMLCGIKHLHSAGI 147
Query: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320
+HRD+KP N++V S+C LKI DFGLAR + MT VVT+YYRAPE+++G + N
Sbjct: 148 IHRDLKPSNIVVKSDCTLKILDFGLART--ACTNFMMTPYVVTRYYRAPEVILGMGYKEN 205
Query: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380
+DIWSVGCI EL+ ++FQ I Q + + + LGTPS E M+ + ++ P
Sbjct: 206 -VDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRP 264
Query: 381 HKQPSLPV-------LYTLSSQ----ATHEAVHLLCRMLVFDPSKRISAKDALAHPYL 427
K P + ++ S+ T +A LL +MLV DP KRIS +AL HPY+
Sbjct: 265 -KYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI 321
>gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2
[Homo sapiens]
Length = 424
Score = 209 bits (532), Expect = 5e-54
Identities = 122/298 (40%), Positives = 178/298 (59%), Gaps = 18/298 (6%)
Query: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
+PIG GA G+V + D G VA+KK+ FQN KR +REL +L H N++S L
Sbjct: 30 KPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLL 89
Query: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
++ P ++ F+++Y+V ELM ++L ++I L + + LYQ+L G+K+LHSAGI
Sbjct: 90 NVFTPQKTLEEFQDVYLVMELMDANLCQVI--HMELDHERMSYLLYQMLCGIKHLHSAGI 147
Query: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320
+HRD+KP N++V S+C LKI DFGLAR + MT VVT+YYRAPE+++G + N
Sbjct: 148 IHRDLKPSNIVVKSDCTLKILDFGLART--ACTNFMMTPYVVTRYYRAPEVILGMGYKEN 205
Query: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380
+DIWSVGCI EL+ ++FQ I Q + + + LGTPS E M+ + ++ P
Sbjct: 206 -VDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRP 264
Query: 381 HKQPSLPV-------LYTLSSQ----ATHEAVHLLCRMLVFDPSKRISAKDALAHPYL 427
K P + ++ S+ T +A LL +MLV DP KRIS +AL HPY+
Sbjct: 265 -KYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI 321
>gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo
sapiens]
Length = 677
Score = 206 bits (525), Expect = 3e-53
Identities = 120/264 (45%), Positives = 162/264 (61%), Gaps = 26/264 (9%)
Query: 222 MQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKIC 281
M+SDLH+II S QPL+ +HV+ FLYQ+LRGLKY+HSA ++HRD+KP NLLVN NC LKI
Sbjct: 1 MESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIG 60
Query: 282 DFGLAR---VEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRR 338
DFG+AR + MT+ V T++YRAPE+++ Y+ AID+WSVGCIF E+L RR
Sbjct: 61 DFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARR 120
Query: 339 ILFQAQSPIQQLDLITDLLGTPSLEAMR-TACEGAKAHILRGPHKQPSLPVLYTLSSQAT 397
LF ++ + QL LI +LGTPS ++ E +A+I P +QP +P T+ A
Sbjct: 121 QLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQP-VP-WETVYPGAD 178
Query: 398 HEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEP 457
+A+ LL RML F+PS RISA AL HP+L +YH D EP
Sbjct: 179 RQALSLLGRMLRFEPSARISAAAALRHPFL----AKYH----------------DPDDEP 218
Query: 458 VTNPKFDDTFEKNLSSVRQVKEII 481
P FD F++ + ++KE I
Sbjct: 219 DCAPPFDFAFDREALTRERIKEAI 242
>gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2
[Homo sapiens]
Length = 427
Score = 204 bits (520), Expect = 1e-52
Identities = 117/298 (39%), Positives = 177/298 (59%), Gaps = 16/298 (5%)
Query: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
+PIG GA G+V + D + VA+KK+ FQN KR +REL ++ H N++ L
Sbjct: 30 KPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLL 89
Query: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
++ P ++ F+++Y+V ELM ++L ++I L + + LYQ+L G+K+LHSAGI
Sbjct: 90 NVFTPQKSLEEFQDVYIVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGI 147
Query: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320
+HRD+KP N++V S+C LKI DFGLAR S MT VVT+YYRAPE+++G + N
Sbjct: 148 IHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVILGMGYKEN 205
Query: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380
+D+WSVGCI E++ +ILF + I Q + + + LGTP E M+ + ++ P
Sbjct: 206 -VDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRP 264
Query: 381 ------HKQPSLPVLYTLSSQ----ATHEAVHLLCRMLVFDPSKRISAKDALAHPYLD 428
++ VL+ S+ +A LL +MLV D SKRIS +AL HPY++
Sbjct: 265 KYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYIN 322
>gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1
[Homo sapiens]
Length = 384
Score = 204 bits (520), Expect = 1e-52
Identities = 117/298 (39%), Positives = 177/298 (59%), Gaps = 16/298 (5%)
Query: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
+PIG GA G+V + D + VA+KK+ FQN KR +REL ++ H N++ L
Sbjct: 30 KPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLL 89
Query: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
++ P ++ F+++Y+V ELM ++L ++I L + + LYQ+L G+K+LHSAGI
Sbjct: 90 NVFTPQKSLEEFQDVYIVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGI 147
Query: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320
+HRD+KP N++V S+C LKI DFGLAR S MT VVT+YYRAPE+++G + N
Sbjct: 148 IHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVILGMGYKEN 205
Query: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380
+D+WSVGCI E++ +ILF + I Q + + + LGTP E M+ + ++ P
Sbjct: 206 -VDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRP 264
Query: 381 ------HKQPSLPVLYTLSSQ----ATHEAVHLLCRMLVFDPSKRISAKDALAHPYLD 428
++ VL+ S+ +A LL +MLV D SKRIS +AL HPY++
Sbjct: 265 KYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYIN 322
>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
[Homo sapiens]
Length = 427
Score = 203 bits (516), Expect = 4e-52
Identities = 117/298 (39%), Positives = 175/298 (58%), Gaps = 16/298 (5%)
Query: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
+PIG GA G+V + D + VA+KK+ FQN KR +REL ++ H N++ L
Sbjct: 30 KPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLL 89
Query: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
++ P ++ F+++Y+V ELM ++L ++I L + + LYQ+L G+K+LHSAGI
Sbjct: 90 NVFTPQKSLEEFQDVYIVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGI 147
Query: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320
+HRD+KP N++V S+C LKI DFGLAR S MT VVT+YYRAPE+++G + N
Sbjct: 148 IHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVILGMGYKEN 205
Query: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380
+DIWSVGCI E++ +LF I Q + + + LGTP E M+ + ++ P
Sbjct: 206 -VDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRP 264
Query: 381 ------HKQPSLPVLYTLSSQ----ATHEAVHLLCRMLVFDPSKRISAKDALAHPYLD 428
++ VL+ S+ +A LL +MLV D SKRIS +AL HPY++
Sbjct: 265 KYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYIN 322
>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
[Homo sapiens]
Length = 384
Score = 203 bits (516), Expect = 4e-52
Identities = 117/298 (39%), Positives = 175/298 (58%), Gaps = 16/298 (5%)
Query: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
+PIG GA G+V + D + VA+KK+ FQN KR +REL ++ H N++ L
Sbjct: 30 KPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLL 89
Query: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
++ P ++ F+++Y+V ELM ++L ++I L + + LYQ+L G+K+LHSAGI
Sbjct: 90 NVFTPQKSLEEFQDVYIVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGI 147
Query: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320
+HRD+KP N++V S+C LKI DFGLAR S MT VVT+YYRAPE+++G + N
Sbjct: 148 IHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVILGMGYKEN 205
Query: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGP 380
+DIWSVGCI E++ +LF I Q + + + LGTP E M+ + ++ P
Sbjct: 206 -VDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRP 264
Query: 381 ------HKQPSLPVLYTLSSQ----ATHEAVHLLCRMLVFDPSKRISAKDALAHPYLD 428
++ VL+ S+ +A LL +MLV D SKRIS +AL HPY++
Sbjct: 265 KYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYIN 322
>gi|4506091 mitogen-activated protein kinase 6 [Homo sapiens]
Length = 721
Score = 194 bits (494), Expect = 1e-49
Identities = 109/298 (36%), Positives = 176/298 (59%), Gaps = 17/298 (5%)
Query: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
+P+G G G+V+S D KRVA+KK+ V + S K RE+K++ HDN++
Sbjct: 24 KPLGCGGNGLVFSAVDNDCDKRVAIKKI--VLTDPQSVKHALREIKIIRRLDHDNIVKVF 81
Query: 202 DILQPP---------HIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGL 252
+IL P + +Y+V E M++DL ++ PL +H ++F+YQ+LRGL
Sbjct: 82 EILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVL-EQGPLLEEHARLFMYQLLRGL 140
Query: 253 KYLHSAGILHRDIKPGNLLVNS-NCVLKICDFGLARVEELDESR--HMTQEVVTQYYRAP 309
KY+HSA +LHRD+KP NL +N+ + VLKI DFGLAR+ + S H+++ +VT++YR+P
Sbjct: 141 KYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSP 200
Query: 310 EILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTAC 369
+L+ +Y+ AID+W+ GCIFAE+L + LF ++Q+ LI + + E +
Sbjct: 201 RLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELL 260
Query: 370 EGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL 427
+I R +P P+ L + EA+ L ++L F P R++A++AL+HPY+
Sbjct: 261 SVIPVYI-RNDMTEPHKPLTQLLPG-ISREALDFLEQILTFSPMDRLTAEEALSHPYM 316
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.134 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,972,513
Number of Sequences: 37866
Number of extensions: 1133993
Number of successful extensions: 17729
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1007
Number of HSP's successfully gapped in prelim test: 360
Number of HSP's that attempted gapping in prelim test: 8596
Number of HSP's gapped (non-prelim): 4715
length of query: 527
length of database: 18,247,518
effective HSP length: 107
effective length of query: 420
effective length of database: 14,195,856
effective search space: 5962259520
effective search space used: 5962259520
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.