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Search of human proteins with 148839466
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
(2986 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 5992 0.0
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 3278 0.0
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 3274 0.0
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 2558 0.0
gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapi... 430 e-120
gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapi... 430 e-120
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens] 246 2e-64
gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens] 246 2e-64
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 239 2e-62
gi|4557511 death-associated protein kinase 3 [Homo sapiens] 231 6e-60
gi|110349719 titin isoform N2-A [Homo sapiens] 231 1e-59
gi|110349717 titin isoform novex-2 [Homo sapiens] 231 1e-59
gi|110349713 titin isoform novex-1 [Homo sapiens] 231 1e-59
gi|110349715 titin isoform N2-B [Homo sapiens] 231 1e-59
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 231 1e-59
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 231 1e-59
gi|153791628 MCF.2 cell line derived transforming sequence isofo... 229 2e-59
gi|153791325 MCF.2 cell line derived transforming sequence isofo... 229 2e-59
gi|188528641 SEC14 and spectrin domains 1 [Homo sapiens] 229 4e-59
gi|14670383 death-associated kinase 2 [Homo sapiens] 228 5e-59
gi|109255245 serine/threonine kinase 17a [Homo sapiens] 200 2e-50
gi|148529025 pleckstrin homology domain containing, family G (wi... 199 3e-50
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 196 2e-49
gi|4758194 serine/threonine kinase 17B [Homo sapiens] 189 3e-47
gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens] 185 7e-46
gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens] 185 7e-46
gi|157785645 SPEG complex locus [Homo sapiens] 184 1e-45
gi|193211603 pleckstrin homology domain containing, family G (wi... 182 6e-45
gi|193211598 pleckstrin homology domain containing, family G (wi... 182 6e-45
gi|193211596 pleckstrin homology domain containing, family G (wi... 182 6e-45
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 5992 bits (15545), Expect = 0.0
Identities = 2986/2986 (100%), Positives = 2986/2986 (100%)
Query: 1 MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTF 60
MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTF
Sbjct: 1 MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTF 60
Query: 61 PARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFP 120
PARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFP
Sbjct: 61 PARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFP 120
Query: 121 AEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNH 180
AEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNH
Sbjct: 121 AEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNH 180
Query: 181 EEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKA 240
EEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKA
Sbjct: 181 EEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKA 240
Query: 241 PVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWH 300
PVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWH
Sbjct: 241 PVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWH 300
Query: 301 VRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMN 360
VRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMN
Sbjct: 301 VRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMN 360
Query: 361 SMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVF 420
SMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVF
Sbjct: 361 SMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVF 420
Query: 421 HQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLD 480
HQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLD
Sbjct: 421 HQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLD 480
Query: 481 VLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCV 540
VLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCV
Sbjct: 481 VLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCV 540
Query: 541 FQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEA 600
FQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEA
Sbjct: 541 FQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEA 600
Query: 601 AEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDL 660
AEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDL
Sbjct: 601 AEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDL 660
Query: 661 QKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSE 720
QKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSE
Sbjct: 661 QKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSE 720
Query: 721 ARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIE 780
ARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIE
Sbjct: 721 ARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIE 780
Query: 781 VTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIT 840
VTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIT
Sbjct: 781 VTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIT 840
Query: 841 EVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVK 900
EVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVK
Sbjct: 841 EVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVK 900
Query: 901 QVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQ 960
QVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQ
Sbjct: 901 QVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQ 960
Query: 961 QKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLE 1020
QKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLE
Sbjct: 961 QKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLE 1020
Query: 1021 SLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYI 1080
SLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYI
Sbjct: 1021 SLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYI 1080
Query: 1081 HRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAK 1140
HRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAK
Sbjct: 1081 HRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAK 1140
Query: 1141 QALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVE 1200
QALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVE
Sbjct: 1141 QALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVE 1200
Query: 1201 KGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDR 1260
KGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDR
Sbjct: 1201 KGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDR 1260
Query: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320
EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP
Sbjct: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320
Query: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380
GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP
Sbjct: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380
Query: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELK 1440
DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELK
Sbjct: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELK 1440
Query: 1441 DGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFL 1500
DGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFL
Sbjct: 1441 DGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFL 1500
Query: 1501 FEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVL 1560
FEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVL
Sbjct: 1501 FEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVL 1560
Query: 1561 KASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGD 1620
KASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGD
Sbjct: 1561 KASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGD 1620
Query: 1621 GSSQPDTISIASRTSQNTVDSDKLSGGCELTVVLQDFSAGHSSELTIQVGQTVELLERPS 1680
GSSQPDTISIASRTSQNTVDSDKLSGGCELTVVLQDFSAGHSSELTIQVGQTVELLERPS
Sbjct: 1621 GSSQPDTISIASRTSQNTVDSDKLSGGCELTVVLQDFSAGHSSELTIQVGQTVELLERPS 1680
Query: 1681 ERPGWCLVRTTERSPPLEGLVPSSALCISHSRSSVEMDCFFPLVKDAYSHSSSENGGKSE 1740
ERPGWCLVRTTERSPPLEGLVPSSALCISHSRSSVEMDCFFPLVKDAYSHSSSENGGKSE
Sbjct: 1681 ERPGWCLVRTTERSPPLEGLVPSSALCISHSRSSVEMDCFFPLVKDAYSHSSSENGGKSE 1740
Query: 1741 SVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSF 1800
SVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSF
Sbjct: 1741 SVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSF 1800
Query: 1801 DLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSSLL 1860
DLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSSLL
Sbjct: 1801 DLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSSLL 1860
Query: 1861 AARQASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEE 1920
AARQASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEE
Sbjct: 1861 AARQASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEE 1920
Query: 1921 EQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIH 1980
EQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIH
Sbjct: 1921 EQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIH 1980
Query: 1981 QIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFE 2040
QIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFE
Sbjct: 1981 QIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFE 2040
Query: 2041 EVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKR 2100
EVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKR
Sbjct: 2041 EVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKR 2100
Query: 2101 CNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELL 2160
CNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELL
Sbjct: 2101 CNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELL 2160
Query: 2161 RKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANADIQQAWVQD 2220
RKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANADIQQAWVQD
Sbjct: 2161 RKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANADIQQAWVQD 2220
Query: 2221 INQVLETQRDFLNALQSPIEYQRKERSTAVMRSQPARLPQASPRPYSSVPAGSEKPPKGS 2280
INQVLETQRDFLNALQSPIEYQRKERSTAVMRSQPARLPQASPRPYSSVPAGSEKPPKGS
Sbjct: 2221 INQVLETQRDFLNALQSPIEYQRKERSTAVMRSQPARLPQASPRPYSSVPAGSEKPPKGS 2280
Query: 2281 SYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEI 2340
SYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEI
Sbjct: 2281 SYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEI 2340
Query: 2341 CVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKS 2400
CVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKS
Sbjct: 2341 CVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKS 2400
Query: 2401 CSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEI 2460
CSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEI
Sbjct: 2401 CSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEI 2460
Query: 2461 LNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSAT 2520
LNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSAT
Sbjct: 2461 LNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSAT 2520
Query: 2521 YTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER 2580
YTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER
Sbjct: 2521 YTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER 2580
Query: 2581 SCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQF 2640
SCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQF
Sbjct: 2581 SCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQF 2640
Query: 2641 RVSASNPWGISLPSEPSEFVRLPEYDAAADGATISWKENFDSAYTELNEIGRGRFSIVKK 2700
RVSASNPWGISLPSEPSEFVRLPEYDAAADGATISWKENFDSAYTELNEIGRGRFSIVKK
Sbjct: 2641 RVSASNPWGISLPSEPSEFVRLPEYDAAADGATISWKENFDSAYTELNEIGRGRFSIVKK 2700
Query: 2701 CIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELM 2760
CIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELM
Sbjct: 2701 CIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELM 2760
Query: 2761 DDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRV 2820
DDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRV
Sbjct: 2761 DDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRV 2820
Query: 2821 KLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPF 2880
KLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPF
Sbjct: 2821 KLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPF 2880
Query: 2881 LDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQP 2940
LDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQP
Sbjct: 2881 LDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQP 2940
Query: 2941 HNGSYSKIPLDTSRLACFIERRKHQNDVRPIPNVKSYIVNRVNQGT 2986
HNGSYSKIPLDTSRLACFIERRKHQNDVRPIPNVKSYIVNRVNQGT
Sbjct: 2941 HNGSYSKIPLDTSRLACFIERRKHQNDVRPIPNVKSYIVNRVNQGT 2986
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 3278 bits (8499), Expect = 0.0
Identities = 1643/1643 (100%), Positives = 1643/1643 (100%)
Query: 1 MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTF 60
MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTF
Sbjct: 1 MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTF 60
Query: 61 PARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFP 120
PARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFP
Sbjct: 61 PARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFP 120
Query: 121 AEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNH 180
AEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNH
Sbjct: 121 AEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNH 180
Query: 181 EEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKA 240
EEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKA
Sbjct: 181 EEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKA 240
Query: 241 PVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWH 300
PVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWH
Sbjct: 241 PVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWH 300
Query: 301 VRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMN 360
VRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMN
Sbjct: 301 VRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMN 360
Query: 361 SMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVF 420
SMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVF
Sbjct: 361 SMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVF 420
Query: 421 HQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLD 480
HQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLD
Sbjct: 421 HQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLD 480
Query: 481 VLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCV 540
VLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCV
Sbjct: 481 VLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCV 540
Query: 541 FQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEA 600
FQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEA
Sbjct: 541 FQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEA 600
Query: 601 AEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDL 660
AEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDL
Sbjct: 601 AEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDL 660
Query: 661 QKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSE 720
QKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSE
Sbjct: 661 QKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSE 720
Query: 721 ARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIE 780
ARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIE
Sbjct: 721 ARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIE 780
Query: 781 VTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIT 840
VTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIT
Sbjct: 781 VTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIT 840
Query: 841 EVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVK 900
EVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVK
Sbjct: 841 EVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVK 900
Query: 901 QVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQ 960
QVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQ
Sbjct: 901 QVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQ 960
Query: 961 QKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLE 1020
QKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLE
Sbjct: 961 QKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLE 1020
Query: 1021 SLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYI 1080
SLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYI
Sbjct: 1021 SLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYI 1080
Query: 1081 HRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAK 1140
HRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAK
Sbjct: 1081 HRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAK 1140
Query: 1141 QALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVE 1200
QALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVE
Sbjct: 1141 QALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVE 1200
Query: 1201 KGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDR 1260
KGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDR
Sbjct: 1201 KGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDR 1260
Query: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320
EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP
Sbjct: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320
Query: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380
GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP
Sbjct: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380
Query: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELK 1440
DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELK
Sbjct: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELK 1440
Query: 1441 DGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFL 1500
DGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFL
Sbjct: 1441 DGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFL 1500
Query: 1501 FEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVL 1560
FEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVL
Sbjct: 1501 FEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVL 1560
Query: 1561 KASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGD 1620
KASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGD
Sbjct: 1561 KASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGD 1620
Query: 1621 GSSQPDTISIASRTSQNTVDSDK 1643
GSSQPDTISIASRTSQNTVDSDK
Sbjct: 1621 GSSQPDTISIASRTSQNTVDSDK 1643
Score = 218 bits (554), Expect = 9e-56
Identities = 121/327 (37%), Positives = 200/327 (61%), Gaps = 11/327 (3%)
Query: 1921 EQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEE--KGVPEDMRGKDKIVFGN 1978
E+K K+ R + F++ EL+QTEK YV+DL +E ++ + + +P + K+ I+FGN
Sbjct: 1273 EEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGN 1332
Query: 1979 IHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DA 2037
I +IYD+H + FL ELEK Q + + F+ K +YV YC+NKP S ++ E+
Sbjct: 1333 IQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGT 1392
Query: 2038 YFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 2097
+F+E++Q ++S +LIKP+QRITKYQLLLK+ L E+ E D +E+M V
Sbjct: 1393 FFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKD---GLEVMLSV 1449
Query: 2098 PKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFS 2157
PK+ ND M++ L+GF+ L QG+L+ QD F V + + + +ER +FLFE ++FS
Sbjct: 1450 PKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWD-PKSLIRKGRERHLFLFEISLVFS 1508
Query: 2158 ELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRET---SERVVLQAANADIQ 2214
+ ++ S Y++K + + L + E+V+ DPCKFAL + T + VL+A+N + +
Sbjct: 1509 KEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETK 1568
Query: 2215 QAWVQDINQVLETQRDFL-NALQSPIE 2240
Q W+++I +V++ + L AL+ P++
Sbjct: 1569 QEWIKNIREVIQERIIHLKGALKEPLQ 1595
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 3274 bits (8490), Expect = 0.0
Identities = 1625/2265 (71%), Positives = 1934/2265 (85%), Gaps = 70/2265 (3%)
Query: 22 RGSFR-NDGLKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTY 80
R FR ND +KA DVLPILKEKVA++SGGRDKRGGPILTFPARSNHDRIRQEDLR+L++Y
Sbjct: 51 RSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISY 110
Query: 81 LASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKT 140
LA +PSE+VCKRGFTVI+DMRGSKWD IKPLLK LQE+FP IHVALIIKPDNFWQKQ+T
Sbjct: 111 LACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRT 170
Query: 141 NFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHL 200
NFGSSKF FET+MVS+EGLTK+VDPSQLT EFDG L+YNHEEWIE+R++ E++ ++A H+
Sbjct: 171 NFGSSKFEFETNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHM 230
Query: 201 LSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSD 260
LSRLE+LQ++LA+KE P D+EG+R +I+EH+QLKKKV+KAP+E+LD EGQ+LLQ I+ S+
Sbjct: 231 LSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSE 290
Query: 261 GFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAE 320
F +N G+AD Q+L+PK++++LD+LHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAE
Sbjct: 291 SFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAE 350
Query: 321 KMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSE 380
KMFDWI+HNK LFL S+TEIG S+ +A++LQTQHNHFAMN MN YVNINRIMSVA+RL E
Sbjct: 351 KMFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVE 410
Query: 381 AGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSE 440
+GHYASQQI+QI++QL+QEWK+FAAALDERST+L MS++FHQKAE+++S VD+WCK C E
Sbjct: 411 SGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGE 470
Query: 441 GGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANY 500
LPSE+QDLE AIHHHQ +YE +T AY+EVSQDGK+LLD LQRPL+PG+S+SLTA+ANY
Sbjct: 471 VDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANY 530
Query: 501 SKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFL 560
SKAVH VLDV+HEVLHHQR+LE+IWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFL
Sbjct: 531 SKAVHHVLDVIHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFL 590
Query: 561 SKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAAR 620
SKHTGVGKSLHRARALQKRH+DFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIY+AA
Sbjct: 591 SKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAH 650
Query: 621 HLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELI 680
LE RIQDFVRRVEQRK+LLDMSVSFHTH KELWTW+E+LQKE+L+DV A+SV+AVQ+LI
Sbjct: 651 QLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLI 710
Query: 681 KQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHI 740
K+F QQQ TL T+NVIKEGEDLIQQL RDSA+S+NKTPH+SSI+HI
Sbjct: 711 KRFGQQQQTTLQVTVNVIKEGEDLIQQL-------------RDSAISSNKTPHNSSINHI 757
Query: 741 ESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFN 800
E+VLQQLD+AQ QMEELF ERKIKL++FLQLRIFE+ I++ ++L++WN++L +QMNDF+
Sbjct: 758 ETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELSQQMNDFD 817
Query: 801 TEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDIDLAAQ 860
TEDLT+AEQRLQ H ++ L MNN+TF+VI QGQDL QY+ EVQASG+EL+C++D+D+A +
Sbjct: 818 TEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATR 877
Query: 861 VQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNA 920
VQ+LLEFLHEKQ EL+L AEQ K LEQC+QLRHLQAEVKQVLGWIRNGESMLNA L+ A
Sbjct: 878 VQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITA 937
Query: 921 SSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIREC 980
SSL EAEQLQREHEQFQ AIE KTHQSALQVQQKAE +LQA HYD D IR+C
Sbjct: 938 SSLQEAEQLQREHEQFQHAIE---------KTHQSALQVQQKAEAMLQANHYDMDMIRDC 988
Query: 981 AEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLG 1040
AEKVA HWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEY+R+EDWCGG DKLG
Sbjct: 989 AEKVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLG 1048
Query: 1041 PAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQ 1100
P +E DHV P+ISKHLEQKEAFLKACTLARRNA+VFLKY+HRN+V+MP + +H + PEQQ
Sbjct: 1049 PNSETDHVTPMISKHLEQKEAFLKACTLARRNADVFLKYLHRNSVNMPGMVTHIKAPEQQ 1108
Query: 1101 VKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTST 1160
VK IL+EL QRENRVLH+WT++KRRLDQCQQYVVFERSAKQAL+WI + GEFYLSTHTST
Sbjct: 1109 VKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTST 1168
Query: 1161 GETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHY 1220
G + + TQELLKE+ EF++ AKQTKE+VKLLIQLAD F EKGH HA EI+K VT VDK Y
Sbjct: 1169 GSSIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRY 1228
Query: 1221 RDFSLRMGKYRYSLEKALGVNTEDN---KDLELDIIPASLSDREVKLRDANHEVNEEKRK 1277
RDFSLRM KYR SLEKALG++++ N K L+LDIIPAS+ EVKLRDA HE+NEEKRK
Sbjct: 1229 RDFSLRMEKYRTSLEKALGISSDSNKSSKSLQLDIIPASIPGSEVKLRDAAHELNEEKRK 1288
Query: 1278 SARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIY 1337
SAR+KEFIMAEL+QTEKAYVRDL EC++TYLWEMTSGVEEIPPGI+NKE IIFGN+QEIY
Sbjct: 1289 SARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIY 1348
Query: 1338 DFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDEI 1397
+FHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDS QLILEHAG++FDEI
Sbjct: 1349 EFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEI 1408
Query: 1398 QQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDAM 1457
QQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGE+KDGLEVMLSVPK+ANDAM
Sbjct: 1409 QQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVPKRANDAM 1468
Query: 1458 HVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGH 1517
H+SMLEGFDEN++ QGELILQ++FQVWDPK+LIRKGRERHLFLFE+SLVFSKE+KDSSG
Sbjct: 1469 HLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGR 1528
Query: 1518 TKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIRE 1577
+KY+YK+KL TSELGVTEHVEGDPCKFALW GRTP+SDNK VLKAS+IE KQ+WIK+IRE
Sbjct: 1529 SKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIRE 1588
Query: 1578 VIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGDGSSQPDTISIASRTSQN 1637
VIQER IHLKGALKEP+ +PKT R +RDG ED+DSQGDGSSQPDTISIASRTSQN
Sbjct: 1589 VIQERTIHLKGALKEPIHIPKTAPATRQKGRRDG-EDLDSQGDGSSQPDTISIASRTSQN 1647
Query: 1638 TVDSDKLSGGCELTVVLQDFSAGHSSELTIQVGQTVELLERPSERPGWCLVRTTERSPPL 1697
T+DSDKLSGGCELTVV+ DF+A +S+ELTI+ GQTVE+LERP ++P WCLVRTT+RSP
Sbjct: 1648 TLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAA 1707
Query: 1698 EGLVPSSALCISHSRSSVEMDCFFPLVKDAYSHSSSENGGKSESVANLQAQPSLNSIHSS 1757
EGLVP +LCI+HSRSS+EM+ F KD+ S SS++ SVA+L QP + SS
Sbjct: 1708 EGLVPCGSLCIAHSRSSMEMEGIFN-HKDSLSVSSND-ASPPASVASL--QPHMIGAQSS 1763
Query: 1758 PGPKRSTNTLKKWLTSPVRRLNSGKADGNIK----KQKKVRDGRKSFDLGSPKPGDET-- 1811
PGPKR NTL+KWLTSPVRRL+SGKADG++K K KK R+ RKS D GS K D++
Sbjct: 1764 PGPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHKHKKSREVRKSADAGSQKDSDDSAA 1823
Query: 1812 TPQGDSADEKSK-----------------KGWGEDEPDEESH-TPLPPPMKIFDND---- 1849
TPQ ++ +E+ + + GE+E +E + PLPPPM I +
Sbjct: 1824 TPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEGEEGADAVPLPPPMAIQQHSLLQP 1883
Query: 1850 PTQDEMSSSLLAARQASTEVPTAADLVNAIEKLVKNKLSLEGSSY-----RGSLKDPA-G 1903
+QD+ +SS L R S+E P+AA+LV+AIE+LVK+K++LE +G P+
Sbjct: 1884 DSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFN 1943
Query: 1904 CLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKG 1963
+ + + P + EE+K+ +L+ R +VL ELV+TE+DYV+DLG VVEG+M ++E G
Sbjct: 1944 PSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDG 2003
Query: 1964 VPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQ 2023
VP+DM+GKDKIVFGNIHQIYDWH+DFFL ELEKC+++ ++L LF+KHER+LH+Y+ YCQ
Sbjct: 2004 VPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQ 2063
Query: 2024 NKPRSEYIVAEY-DAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGL 2082
NKP+SE+IV+EY D +FE++KQ + RL L+D LIKP+QRI KYQLLLKDFL+YS+KA L
Sbjct: 2064 NKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASL 2123
Query: 2083 ECSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRT 2142
+ S++E+AVE+MC+VP+RCNDMMN+GRLQGF+G + AQGKLL QDTF V + DAG+ R
Sbjct: 2124 DTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLVTDQDAGLLPRC 2183
Query: 2143 KERRVFLFEQIVIFSELL--RKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNR-- 2198
+ERR+FLFEQIVIFSE L +KG PG++FK SIK++ L LEENV+NDPCKFAL +R
Sbjct: 2184 RERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTG 2243
Query: 2199 ETSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQR 2243
+ E +L +++ ++Q W+ +INQ+LE QR+FLNAL SPIEYQR
Sbjct: 2244 DVVETFILHSSSPSVRQTWIHEINQILENQRNFLNALTSPIEYQR 2288
Score = 388 bits (997), Expect = e-107
Identities = 181/313 (57%), Positives = 244/313 (77%), Gaps = 1/313 (0%)
Query: 2670 DGATISWKENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEA 2729
DG ++WK+NFDS Y+E+ E+GRGRFS+VKKC K T++ VA KFV+KK+ K++Q HE
Sbjct: 2782 DGIMVTWKDNFDSFYSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMKRDQVTHEL 2841
Query: 2730 ALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIME 2789
+LQ LQHP + L DT+E+PTSYIL+LE+ D GRLLD ++ L E K+ ++ +++E
Sbjct: 2842 GILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDCVVRWGSLTEGKIRAHLGEVLE 2901
Query: 2790 ALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAP 2849
A++YLHNCR+AHLD+KPEN+L+D + P +KL D DAVQ++ ++IH LLGNPEFAAP
Sbjct: 2902 AVRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAAP 2961
Query: 2850 EVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSN 2909
E+I G PVSL +D WS+GVLTYV+LSGVSPFLD+S EETC+N+CR+DFSFP +YF GVS
Sbjct: 2962 EIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQ 3021
Query: 2910 AARDFINVILQEDFRRRPTAATCLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQNDVR 2969
A++F+ +LQED +RP+AA LQ WLQ NG + + LDTSRL FIERRKHQNDVR
Sbjct: 3022 KAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGRSTGV-LDTSRLTSFIERRKHQNDVR 3080
Query: 2970 PIPNVKSYIVNRV 2982
PI ++K+++ +R+
Sbjct: 3081 PIRSIKNFLQSRL 3093
Score = 235 bits (600), Expect = 4e-61
Identities = 144/341 (42%), Positives = 200/341 (58%), Gaps = 44/341 (12%)
Query: 2247 STAVMRSQPARLPQASPRP-----YSSVPAGSEKPPKGSSYNPPLPPLKISTS-NGSPGF 2300
S+AV P +SP +SS+PA P ++ L+ T + +PG
Sbjct: 2462 SSAVPSLGKEPFPPSSPLQKGGSFWSSIPASPASRPGSFTFPGDSDSLQRQTPRHAAPGK 2521
Query: 2301 EYHQPGDKFEASKQN---------DLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVL 2351
+ + AS+Q+ + + S+M V DY A+KE+EI V QGEVVQ+L
Sbjct: 2522 DTDRMSTCSSASEQSVQSTQSNGSESSSSSNISTMLVTHDYTAVKEDEINVYQGEVVQIL 2581
Query: 2352 AVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHT-LRMRK 2410
A NQQNM LV++ A+D PAAEGW+PG +L T A E+ DG++KKS SWHT LR+RK
Sbjct: 2582 ASNQQNMFLVFRAATDQCPAAEGWIPGFVLGH-TSAVIVENPDGTLKKSTSWHTALRLRK 2640
Query: 2411 RAEVENT-GKNEA---TGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFI 2466
++E ++ GK E G RK ++ L NKVSVK +LNPN+I
Sbjct: 2641 KSEKKDKDGKREGKLENGYRKSREGLSNKVSVK--------------------LLNPNYI 2680
Query: 2467 QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
+V PEF++PL +VTC G+TV+L+C+VCGRPK +ITWKGP+ N L+ D Y++S
Sbjct: 2681 YDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTLNNDGH---YSISYS 2737
Query: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG 2567
D GE TLKI + +D GIYTCIA ND G+ S+SA+++V G
Sbjct: 2738 DLGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLG 2778
Score = 235 bits (599), Expect = 6e-61
Identities = 167/527 (31%), Positives = 280/527 (53%), Gaps = 52/527 (9%)
Query: 1921 EQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEE--KGVPEDMRGKDKIVFGN 1978
E+K K+ R + F++ EL+QTEK YV+DL ++ ++ + + +P + K+ I+FGN
Sbjct: 1284 EEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGN 1343
Query: 1979 IHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DA 2037
+ +IY++H + FL ELEK Q + + F+ K +YV YC+NKP S ++ E+ +
Sbjct: 1344 MQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGS 1403
Query: 2038 YFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 2097
YF+E++Q ++S +LIKP+QRITKYQLLLK+ L E+ E D +E+M V
Sbjct: 1404 YFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKD---GLEVMLSV 1460
Query: 2098 PKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFS 2157
PKR ND M+L L+GF+ + +QG+L+ Q++F V + ++ + +ER +FLFE ++FS
Sbjct: 1461 PKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIR-KGRERHLFLFEMSLVFS 1519
Query: 2158 ELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRET---SERVVLQAANADIQ 2214
+ ++ S Y++K + + L + E+V+ DPCKFAL T ++VL+A++ + +
Sbjct: 1520 KEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENK 1579
Query: 2215 QAWVQDINQVLETQRDFLN-ALQSPIEYQRKERSTAVMRSQPARLPQASPRPYSSVPAGS 2273
Q W++ I +V++ + L AL+ PI + TA Q R G
Sbjct: 1580 QDWIKHIREVIQERTIHLKGALKEPIHIPK----TAPATRQKGRRD------------GE 1623
Query: 2274 EKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLGGCNGTSSMAVIKDYY 2333
+ +G + P + I++ + DK GGC T VI D+
Sbjct: 1624 DLDSQGDGSSQP-DTISIASRTSQNTLD----SDKLS-------GGCELT---VVIHDFT 1668
Query: 2334 ALKENEICVSQGEVVQVLAV--NQQNMCLVYQPASDHSPAAEGWVP-GSILAPLTKATAA 2390
A NE+ + +G+ V+VL ++ + CLV +D SPAAEG VP GS+ ++++
Sbjct: 1669 ACNSNELTIRRGQTVEVLERPHDKPDWCLVR--TTDRSPAAEGLVPCGSLCIAHSRSSME 1726
Query: 2391 ESSDGSIKKSCSWHTLRMRKRAEVEN-----TGKNEATGPRKPKDIL 2432
+ K S S + A V + G + GP++P + L
Sbjct: 1727 MEGIFNHKDSLSVSSNDASPPASVASLQPHMIGAQSSPGPKRPGNTL 1773
>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
Length = 1289
Score = 2558 bits (6629), Expect = 0.0
Identities = 1264/1268 (99%), Positives = 1265/1268 (99%), Gaps = 1/1268 (0%)
Query: 1719 CFFPLVKDAYSHSSSENGGKSESVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRL 1778
C FP +DAYSHSSSENGGKSESVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRL
Sbjct: 23 CCFPC-RDAYSHSSSENGGKSESVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRL 81
Query: 1779 NSGKADGNIKKQKKVRDGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTP 1838
NSGKADGNIKKQKKVRDGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTP
Sbjct: 82 NSGKADGNIKKQKKVRDGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTP 141
Query: 1839 LPPPMKIFDNDPTQDEMSSSLLAARQASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSL 1898
LPPPMKIFDNDPTQDEMSSSLLAARQASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSL
Sbjct: 142 LPPPMKIFDNDPTQDEMSSSLLAARQASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSL 201
Query: 1899 KDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKR 1958
KDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKR
Sbjct: 202 KDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKR 261
Query: 1959 IEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIY 2018
IEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIY
Sbjct: 262 IEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIY 321
Query: 2019 VWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSE 2078
VWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSE
Sbjct: 322 VWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSE 381
Query: 2079 KAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGM 2138
KAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGM
Sbjct: 382 KAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGM 441
Query: 2139 QSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNR 2198
QSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNR
Sbjct: 442 QSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNR 501
Query: 2199 ETSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAVMRSQPARL 2258
ETSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAVMRSQPARL
Sbjct: 502 ETSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAVMRSQPARL 561
Query: 2259 PQASPRPYSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLG 2318
PQASPRPYSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLG
Sbjct: 562 PQASPRPYSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLG 621
Query: 2319 GCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPG 2378
GCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPG
Sbjct: 622 GCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPG 681
Query: 2379 SILAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSV 2438
SILAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSV
Sbjct: 682 SILAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSV 741
Query: 2439 KETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRP 2498
KETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRP
Sbjct: 742 KETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRP 801
Query: 2499 KPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTS 2558
KPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTS
Sbjct: 802 KPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTS 861
Query: 2559 TSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQS 2618
TSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQS
Sbjct: 862 TSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQS 921
Query: 2619 VASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAADGATISWKE 2678
VASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAADGATISWKE
Sbjct: 922 VASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAADGATISWKE 981
Query: 2679 NFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHP 2738
NFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHP
Sbjct: 982 NFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHP 1041
Query: 2739 QYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCR 2798
QYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCR
Sbjct: 1042 QYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCR 1101
Query: 2799 VAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVS 2858
VAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVS
Sbjct: 1102 VAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVS 1161
Query: 2859 LGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVI 2918
LGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVI
Sbjct: 1162 LGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVI 1221
Query: 2919 LQEDFRRRPTAATCLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQNDVRPIPNVKSYI 2978
LQEDFRRRPTAATCLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQNDVRPIPNVKSYI
Sbjct: 1222 LQEDFRRRPTAATCLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQNDVRPIPNVKSYI 1281
Query: 2979 VNRVNQGT 2986
VNRVNQGT
Sbjct: 1282 VNRVNQGT 1289
Score = 231 bits (588), Expect = 1e-59
Identities = 162/512 (31%), Positives = 267/512 (52%), Gaps = 53/512 (10%)
Query: 1273 EEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGN 1332
E+K K+ R + F++ EL+QTEK YV+DL +E ++ + + +P + K+ I+FGN
Sbjct: 224 EQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEE--KGVPEDMRGKDKIVFGN 281
Query: 1333 IQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGT 1392
I +IYD+H + FL ELEK Q + + F+ K +YV YC+NKP S ++ E+
Sbjct: 282 IHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DA 340
Query: 1393 FFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKD---GLEVMLSV 1449
+F+E++Q ++S +LIKP+QRITKYQLLLK+ L E+ E D +E+M V
Sbjct: 341 YFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 400
Query: 1450 PKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWD-PKSLIRKGRERHLFLFEISLVFS 1508
PK+ ND M++ L+GF+ L QG+L+ QD F V + + + +ER +FLFE ++FS
Sbjct: 401 PKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFS 460
Query: 1509 KEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETK 1568
+ ++ S Y++K + + L + E+V+ DPCKFAL + T + VL+A+N + +
Sbjct: 461 ELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRET---SERVVLQAANADIQ 517
Query: 1569 QEWIKNIREVIQERIIHLKGALKEPLQL---PKTPAKQRNNSKR---DGVEDIDSQGDGS 1622
Q W+++I +V++ + L AL+ P++ ++ A R+ R S GS
Sbjct: 518 QAWVQDINQVLETQRDFL-NALQSPIEYQRKERSTAVMRSQPARLPQASPRPYSSVPAGS 576
Query: 1623 SQPD--------------TISIASRTSQNTVDSDKLS-------GGCELT---VVLQDFS 1658
+P + S S + DK GGC T V++D+
Sbjct: 577 EKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLGGCNGTSSMAVIKDYY 636
Query: 1659 AGHSSELTIQVGQTVELLERPSERPGWCLV--RTTERSPPLEGLVPSS-------ALCIS 1709
A +E+ + G+ V++L + CLV ++ SP EG VP S A
Sbjct: 637 ALKENEICVSQGEVVQVL--AVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAAE 694
Query: 1710 HSRSSVEMDCFFPLVKDAYSHSSSENGGKSES 1741
S S++ C + ++ + EN GK+E+
Sbjct: 695 SSDGSIKKSCSWHTLR-MRKRAEVENTGKNEA 725
>gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapiens]
Length = 580
Score = 430 bits (1106), Expect = e-120
Identities = 212/339 (62%), Positives = 274/339 (80%), Gaps = 9/339 (2%)
Query: 1919 EEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGN 1978
EEEQK KAL M+VL+ELV+TEK YV DLG +VEG+M + +GVPE +RG+D+IVFGN
Sbjct: 150 EEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGN 209
Query: 1979 IHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DA 2037
I QIY+WH+D+FL EL++C+++ D LAQLFIKHER+LH+YV YCQNKP+SE++V+E+ D+
Sbjct: 210 IQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDS 269
Query: 2038 YFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 2097
YFEE++Q++ RL L+D LIKP+QRI KYQLLLKDFL+Y +AG++ +D+E+AVE+MC V
Sbjct: 270 YFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFV 329
Query: 2098 PKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAG--MQSRTKERRVFLFEQIVI 2155
PKRCNDMM LGRL+GFEG LTAQGKLL QDTF+V E +AG + SR +ERRVFLFEQI+I
Sbjct: 330 PKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIII 389
Query: 2156 FSELLR---KGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETS---ERVVLQAA 2209
FSE L +G PGY++K SIK++ L LE N+ DPC+FAL +R +R VLQAA
Sbjct: 390 FSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAA 449
Query: 2210 NADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERST 2248
+ I QAW++ + Q+LE+QRDFLNALQSPIEYQR+E T
Sbjct: 450 DPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQT 488
Score = 231 bits (589), Expect = 8e-60
Identities = 134/387 (34%), Positives = 222/387 (57%), Gaps = 20/387 (5%)
Query: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320
E L A E+K+K+ + ++++EL++TEK YV DL + +E Y+ T + +P
Sbjct: 140 EETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM--ATMAAQGVPE 197
Query: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380
+ ++ I+FGNIQ+IY++H + FL+EL++ + P+ + F+ + MYV YC+NKP
Sbjct: 198 SLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKP 257
Query: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG---KG 1437
S ++ E ++F+E++Q+ G ++ LIKPVQRI KYQLLLK+ L
Sbjct: 258 KSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTA 317
Query: 1438 ELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKS---LIRKGR 1494
+L+ +EVM VPK+ ND M + L GF+ L QG+L+ QD F V +P++ L +GR
Sbjct: 318 DLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGR 377
Query: 1495 ERHLFLFEISLVFSKEIKDS-SGHTK--YVYKNKLLTSELGVTEHVEGDPCKFALWSGRT 1551
ER +FLFE ++FS+ + G T+ YVYKN + S LG+ +++GDPC+FAL S
Sbjct: 378 ERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGP 437
Query: 1552 PSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDG 1611
+ VL+A++ Q WIK++ ++++ + L AL+ P++ QR S+ +
Sbjct: 438 EGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL-NALQSPIEY------QRRESQTNS 490
Query: 1612 VEDIDSQGDGSSQPDTISIASRTSQNT 1638
+ +G G P I + + +T
Sbjct: 491 LG--RPRGPGVGSPGRIRLGDQAQGST 515
>gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapiens]
Length = 619
Score = 430 bits (1106), Expect = e-120
Identities = 212/339 (62%), Positives = 274/339 (80%), Gaps = 9/339 (2%)
Query: 1919 EEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGN 1978
EEEQK KAL M+VL+ELV+TEK YV DLG +VEG+M + +GVPE +RG+D+IVFGN
Sbjct: 189 EEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGN 248
Query: 1979 IHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DA 2037
I QIY+WH+D+FL EL++C+++ D LAQLFIKHER+LH+YV YCQNKP+SE++V+E+ D+
Sbjct: 249 IQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDS 308
Query: 2038 YFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 2097
YFEE++Q++ RL L+D LIKP+QRI KYQLLLKDFL+Y +AG++ +D+E+AVE+MC V
Sbjct: 309 YFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFV 368
Query: 2098 PKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAG--MQSRTKERRVFLFEQIVI 2155
PKRCNDMM LGRL+GFEG LTAQGKLL QDTF+V E +AG + SR +ERRVFLFEQI+I
Sbjct: 369 PKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIII 428
Query: 2156 FSELLR---KGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETS---ERVVLQAA 2209
FSE L +G PGY++K SIK++ L LE N+ DPC+FAL +R +R VLQAA
Sbjct: 429 FSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAA 488
Query: 2210 NADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERST 2248
+ I QAW++ + Q+LE+QRDFLNALQSPIEYQR+E T
Sbjct: 489 DPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQT 527
Score = 231 bits (589), Expect = 8e-60
Identities = 134/387 (34%), Positives = 222/387 (57%), Gaps = 20/387 (5%)
Query: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320
E L A E+K+K+ + ++++EL++TEK YV DL + +E Y+ T + +P
Sbjct: 179 EETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM--ATMAAQGVPE 236
Query: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380
+ ++ I+FGNIQ+IY++H + FL+EL++ + P+ + F+ + MYV YC+NKP
Sbjct: 237 SLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKP 296
Query: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG---KG 1437
S ++ E ++F+E++Q+ G ++ LIKPVQRI KYQLLLK+ L
Sbjct: 297 KSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTA 356
Query: 1438 ELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKS---LIRKGR 1494
+L+ +EVM VPK+ ND M + L GF+ L QG+L+ QD F V +P++ L +GR
Sbjct: 357 DLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGR 416
Query: 1495 ERHLFLFEISLVFSKEIKDS-SGHTK--YVYKNKLLTSELGVTEHVEGDPCKFALWSGRT 1551
ER +FLFE ++FS+ + G T+ YVYKN + S LG+ +++GDPC+FAL S
Sbjct: 417 ERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGP 476
Query: 1552 PSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDG 1611
+ VL+A++ Q WIK++ ++++ + L AL+ P++ QR S+ +
Sbjct: 477 EGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL-NALQSPIEY------QRRESQTNS 529
Query: 1612 VEDIDSQGDGSSQPDTISIASRTSQNT 1638
+ +G G P I + + +T
Sbjct: 530 LG--RPRGPGVGSPGRIRLGDQAQGST 554
>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
Length = 1914
Score = 246 bits (629), Expect = 2e-64
Identities = 175/588 (29%), Positives = 277/588 (47%), Gaps = 47/588 (7%)
Query: 2415 ENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFL 2474
ENT E R+PK L + + + ++ P +M P IQ PE
Sbjct: 1194 ENTKAPEMKS-RRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMP---PQIIQ--FPE-- 1245
Query: 2475 VPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLK 2534
D G++V L KV G T TW + I ++++ V + ++G L
Sbjct: 1246 ----DQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMK----VENSENGS-KLT 1296
Query: 2535 ICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAP-NRPIAQERSCTSVILRWLPPS 2593
I + G YT + N G+ + V P P P A + +S+ L W S
Sbjct: 1297 ILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSS 1356
Query: 2594 STGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP 2653
G + Y++E + ++ W++ +A+ T ++DL P Y+FRV A N +G S P
Sbjct: 1357 YDGGSAVQSYSIEIWDSANKTWKE-LATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEP 1415
Query: 2654 SEPSEFVRL--------------------PEYDAAADGATISWKENFDSAYTELNEIGRG 2693
S+ SE + PE D TI+ ++ Y +G G
Sbjct: 1416 SQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRT--VTINTEQKVSDFYDIEERLGSG 1473
Query: 2694 RFSIVKKCIHKATRKDVAVKFVSK-KMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTS 2752
+F V + + K TRK A KF K+KE E +++ L HP+ + D +E +
Sbjct: 1474 KFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKAN 1533
Query: 2753 YILILELMDDGRLLDYLMNHD-ELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLI 2811
+++LE++ G L + +++ D EL E + Y+R I E ++Y+H + HLD+KPEN++
Sbjct: 1534 IVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMC 1593
Query: 2812 DLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTY 2871
+ R+KLID A ++ + L G PEF APEVI P+ TD+WSIGV+ Y
Sbjct: 1594 VNKTGT-RIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICY 1652
Query: 2872 VMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAAT 2931
+++SG+SPF+ ++ ET NV + F E F +S+ A+DFI+ +L++D + R
Sbjct: 1653 ILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQ 1712
Query: 2932 CLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQ---NDVRPIPNVKS 2976
CLQHPWL + L R+ ++ RRK Q N VR I + S
Sbjct: 1713 CLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSS 1760
Score = 71.2 bits (173), Expect = 1e-11
Identities = 45/122 (36%), Positives = 58/122 (47%), Gaps = 18/122 (14%)
Query: 2466 IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSS 2525
+ EVAP F L D + G +LQC V G P P ITW Q I Y S+
Sbjct: 509 VMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI--------QYARST 560
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG----------VPAAPNRP 2575
C++G L I + +P+D G YTC+A N G S SA V V +P AP++P
Sbjct: 561 CEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKP 620
Query: 2576 IA 2577
A
Sbjct: 621 TA 622
Score = 60.1 bits (144), Expect = 3e-08
Identities = 40/126 (31%), Positives = 60/126 (47%), Gaps = 6/126 (4%)
Query: 2463 PNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYT 2522
P+ E P+F L V G CK+ GRP+P +TW + + SA +
Sbjct: 153 PSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPL----QPSARVS 208
Query: 2523 VSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSC 2582
VS +G L+I + D G+YTC+ N G S SA + +QG+ +A NR +E
Sbjct: 209 VSE-KNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSA-NRSFVRETKA 266
Query: 2583 TSVILR 2588
T+ +R
Sbjct: 267 TNSDVR 272
Score = 58.9 bits (141), Expect = 7e-08
Identities = 58/241 (24%), Positives = 89/241 (36%), Gaps = 37/241 (15%)
Query: 2343 SQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAAESSD--GSIKKS 2400
S E + AV QP+ P P L P+ A AE+ G+ K
Sbjct: 998 SSAETLNAKAVESSKPLSNAQPSGPLKPVGNA-KPAETLKPMGNAKPAETLKPMGNAKPD 1056
Query: 2401 CSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEI 2460
L+ + E++ KN D+ + T++ + SE
Sbjct: 1057 ---ENLKSASKEELKKDVKN---------DVNCKRGHAGTTDNEKRSES----------- 1093
Query: 2461 LNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSAT 2520
Q AP F L DV G ++LQC+V P TI W + + T
Sbjct: 1094 ------QGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK----- 1142
Query: 2521 YTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER 2580
+ + S + ++ I +P+D G+Y C+A ND G S V V PA+ N + +
Sbjct: 1143 FIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMK 1202
Query: 2581 S 2581
S
Sbjct: 1203 S 1203
Score = 50.1 bits (118), Expect = 3e-05
Identities = 59/224 (26%), Positives = 96/224 (42%), Gaps = 30/224 (13%)
Query: 2436 VSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVC 2495
V+V E SS +SE +L + AP FL L D+ + G V + +V
Sbjct: 598 VTVHEKKSSRKSEY----------LLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVS 647
Query: 2496 GRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHG 2555
G P P + W I ++++ + + +L I + P+D+G YTC A N G
Sbjct: 648 GNPPPEVIWLHNGNEIQESEDFHFEQRGT-----QHSLCIQEVFPEDTGTYTCEAWNSAG 702
Query: 2556 TTSTSATVKVQGVPAAPNRP--IAQERSCTSVILRWLPPSSTGNCTISG---YTVEYREE 2610
T A + VQ P +P I++ RS T+ L S +C I+G TV + +
Sbjct: 703 EVRTQAVLTVQ-EPHDGTQPWFISKPRSVTAS----LGQSVLISCAIAGDPFPTVHWLRD 757
Query: 2611 GSQIWQQS----VASTLDTY-LVIEDLSPGCPYQFRVSASNPWG 2649
G + + + V D + LV++ + P Q+ + N G
Sbjct: 758 GKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVG 801
Score = 45.8 bits (107), Expect = 6e-04
Identities = 29/98 (29%), Positives = 45/98 (45%), Gaps = 4/98 (4%)
Query: 2470 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG 2529
AP F++P ++ G T + +V G P+P +TW Q I S + + G
Sbjct: 32 APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPI----TSGGRFLLDCGIRG 87
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG 2567
+L I + +D G YTC ATN G + + V+G
Sbjct: 88 TFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEG 125
Score = 45.4 bits (106), Expect = 8e-04
Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 4/98 (4%)
Query: 2469 VAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDS 2528
V P F + D+ + G CK+ G P P + W DQ+I ++ + Y +
Sbjct: 1807 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYD----ED 1862
Query: 2529 GEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
G +L I ++ D YTC A N G + +A + V+
Sbjct: 1863 GNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 1900
Score = 44.7 bits (104), Expect = 0.001
Identities = 26/80 (32%), Positives = 39/80 (48%), Gaps = 4/80 (5%)
Query: 2487 TVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIY 2546
TV +C+V G PKP + W + + S Y D+G L + +DSG Y
Sbjct: 430 TVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYE----DAGSHYLCLLKARTRDSGTY 485
Query: 2547 TCIATNDHGTTSTSATVKVQ 2566
+C A+N G S S T++V+
Sbjct: 486 SCTASNAQGQLSCSWTLQVE 505
Score = 35.0 bits (79), Expect = 1.1
Identities = 25/101 (24%), Positives = 42/101 (41%), Gaps = 6/101 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNIL-DTDNSSATYTVSSCDSG 2529
P F+ VT LG +V++ C + G P PT+ W + + DT + +
Sbjct: 721 PWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQ-----NED 775
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPA 2570
TL + + P +G Y + N G S ++ +Q A
Sbjct: 776 VFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSA 816
>gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]
Length = 1845
Score = 246 bits (629), Expect = 2e-64
Identities = 175/588 (29%), Positives = 277/588 (47%), Gaps = 47/588 (7%)
Query: 2415 ENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFL 2474
ENT E R+PK L + + + ++ P +M P IQ PE
Sbjct: 1125 ENTKAPEMKS-RRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMP---PQIIQ--FPE-- 1176
Query: 2475 VPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLK 2534
D G++V L KV G T TW + I ++++ V + ++G L
Sbjct: 1177 ----DQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMK----VENSENGS-KLT 1227
Query: 2535 ICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAP-NRPIAQERSCTSVILRWLPPS 2593
I + G YT + N G+ + V P P P A + +S+ L W S
Sbjct: 1228 ILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSS 1287
Query: 2594 STGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP 2653
G + Y++E + ++ W++ +A+ T ++DL P Y+FRV A N +G S P
Sbjct: 1288 YDGGSAVQSYSIEIWDSANKTWKE-LATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEP 1346
Query: 2654 SEPSEFVRL--------------------PEYDAAADGATISWKENFDSAYTELNEIGRG 2693
S+ SE + PE D TI+ ++ Y +G G
Sbjct: 1347 SQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRT--VTINTEQKVSDFYDIEERLGSG 1404
Query: 2694 RFSIVKKCIHKATRKDVAVKFVSK-KMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTS 2752
+F V + + K TRK A KF K+KE E +++ L HP+ + D +E +
Sbjct: 1405 KFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKAN 1464
Query: 2753 YILILELMDDGRLLDYLMNHD-ELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLI 2811
+++LE++ G L + +++ D EL E + Y+R I E ++Y+H + HLD+KPEN++
Sbjct: 1465 IVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMC 1524
Query: 2812 DLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTY 2871
+ R+KLID A ++ + L G PEF APEVI P+ TD+WSIGV+ Y
Sbjct: 1525 VNKTGT-RIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICY 1583
Query: 2872 VMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAAT 2931
+++SG+SPF+ ++ ET NV + F E F +S+ A+DFI+ +L++D + R
Sbjct: 1584 ILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQ 1643
Query: 2932 CLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQ---NDVRPIPNVKS 2976
CLQHPWL + L R+ ++ RRK Q N VR I + S
Sbjct: 1644 CLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSS 1691
Score = 71.2 bits (173), Expect = 1e-11
Identities = 45/122 (36%), Positives = 58/122 (47%), Gaps = 18/122 (14%)
Query: 2466 IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSS 2525
+ EVAP F L D + G +LQC V G P P ITW Q I Y S+
Sbjct: 440 VMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI--------QYARST 491
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG----------VPAAPNRP 2575
C++G L I + +P+D G YTC+A N G S SA V V +P AP++P
Sbjct: 492 CEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKP 551
Query: 2576 IA 2577
A
Sbjct: 552 TA 553
Score = 60.1 bits (144), Expect = 3e-08
Identities = 40/126 (31%), Positives = 60/126 (47%), Gaps = 6/126 (4%)
Query: 2463 PNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYT 2522
P+ E P+F L V G CK+ GRP+P +TW + + SA +
Sbjct: 153 PSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPL----QPSARVS 208
Query: 2523 VSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSC 2582
VS +G L+I + D G+YTC+ N G S SA + +QG+ +A NR +E
Sbjct: 209 VSE-KNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSA-NRSFVRETKA 266
Query: 2583 TSVILR 2588
T+ +R
Sbjct: 267 TNSDVR 272
Score = 58.9 bits (141), Expect = 7e-08
Identities = 58/241 (24%), Positives = 89/241 (36%), Gaps = 37/241 (15%)
Query: 2343 SQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAAESSD--GSIKKS 2400
S E + AV QP+ P P L P+ A AE+ G+ K
Sbjct: 929 SSAETLNAKAVESSKPLSNAQPSGPLKPVGNA-KPAETLKPMGNAKPAETLKPMGNAKPD 987
Query: 2401 CSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEI 2460
L+ + E++ KN D+ + T++ + SE
Sbjct: 988 ---ENLKSASKEELKKDVKN---------DVNCKRGHAGTTDNEKRSES----------- 1024
Query: 2461 LNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSAT 2520
Q AP F L DV G ++LQC+V P TI W + + T
Sbjct: 1025 ------QGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK----- 1073
Query: 2521 YTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER 2580
+ + S + ++ I +P+D G+Y C+A ND G S V V PA+ N + +
Sbjct: 1074 FIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMK 1133
Query: 2581 S 2581
S
Sbjct: 1134 S 1134
Score = 50.1 bits (118), Expect = 3e-05
Identities = 59/224 (26%), Positives = 96/224 (42%), Gaps = 30/224 (13%)
Query: 2436 VSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVC 2495
V+V E SS +SE +L + AP FL L D+ + G V + +V
Sbjct: 529 VTVHEKKSSRKSEY----------LLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVS 578
Query: 2496 GRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHG 2555
G P P + W I ++++ + + +L I + P+D+G YTC A N G
Sbjct: 579 GNPPPEVIWLHNGNEIQESEDFHFEQRGT-----QHSLCIQEVFPEDTGTYTCEAWNSAG 633
Query: 2556 TTSTSATVKVQGVPAAPNRP--IAQERSCTSVILRWLPPSSTGNCTISG---YTVEYREE 2610
T A + VQ P +P I++ RS T+ L S +C I+G TV + +
Sbjct: 634 EVRTQAVLTVQ-EPHDGTQPWFISKPRSVTAS----LGQSVLISCAIAGDPFPTVHWLRD 688
Query: 2611 GSQIWQQS----VASTLDTY-LVIEDLSPGCPYQFRVSASNPWG 2649
G + + + V D + LV++ + P Q+ + N G
Sbjct: 689 GKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVG 732
Score = 45.8 bits (107), Expect = 6e-04
Identities = 29/98 (29%), Positives = 45/98 (45%), Gaps = 4/98 (4%)
Query: 2470 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG 2529
AP F++P ++ G T + +V G P+P +TW Q I S + + G
Sbjct: 32 APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPI----TSGGRFLLDCGIRG 87
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG 2567
+L I + +D G YTC ATN G + + V+G
Sbjct: 88 TFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEG 125
Score = 45.4 bits (106), Expect = 8e-04
Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 4/98 (4%)
Query: 2469 VAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDS 2528
V P F + D+ + G CK+ G P P + W DQ+I ++ + Y +
Sbjct: 1738 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYD----ED 1793
Query: 2529 GEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
G +L I ++ D YTC A N G + +A + V+
Sbjct: 1794 GNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 1831
Score = 35.0 bits (79), Expect = 1.1
Identities = 25/101 (24%), Positives = 42/101 (41%), Gaps = 6/101 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNIL-DTDNSSATYTVSSCDSG 2529
P F+ VT LG +V++ C + G P PT+ W + + DT + +
Sbjct: 652 PWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQ-----NED 706
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPA 2570
TL + + P +G Y + N G S ++ +Q A
Sbjct: 707 VFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSA 747
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 239 bits (611), Expect = 2e-62
Identities = 123/311 (39%), Positives = 185/311 (59%), Gaps = 12/311 (3%)
Query: 2673 TISWKENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKK-------KEQA 2725
T+ +EN D Y E+G G+F++VKKC K+T A KF+ K+ K +E
Sbjct: 2 TVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDI 61
Query: 2726 AHEAALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIR 2785
E ++L+ +QHP ITLH+ YE+ T ILILEL+ G L D+L + L EE+ +++
Sbjct: 62 EREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLK 121
Query: 2786 DIMEALQYLHNCRVAHLDIKPENL-LIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNP 2844
I+ + YLH+ ++AH D+KPEN+ L+D +P PR+K+ID A +I ++ G P
Sbjct: 122 QILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTP 181
Query: 2845 EFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYF 2904
EF APE++ P+ L D+WSIGV+TY++LSG SPFL ++K+ET NV V++ F EYF
Sbjct: 182 EFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYF 241
Query: 2905 CGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQPHNG----SYSKIPLDTSRLACFIE 2960
S A+DFI +L +D ++R T LQHPW++P + S ++ + F
Sbjct: 242 SNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAA 301
Query: 2961 RRKHQNDVRPI 2971
R+K + VR I
Sbjct: 302 RKKWKQSVRLI 312
>gi|4557511 death-associated protein kinase 3 [Homo sapiens]
Length = 454
Score = 231 bits (590), Expect = 6e-60
Identities = 111/271 (40%), Positives = 170/271 (62%), Gaps = 8/271 (2%)
Query: 2677 KENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKK-------KEQAAHEA 2729
+E+ + Y E+G G+F+IV+KC K T K+ A KF+ K+ +E+ E
Sbjct: 6 QEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREV 65
Query: 2730 ALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIME 2789
+L+ ++HP ITLHD +E+ T +LILEL+ G L D+L + L E++ +++ I++
Sbjct: 66 NILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILD 125
Query: 2790 ALQYLHNCRVAHLDIKPENL-LIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAA 2848
+ YLH+ R+AH D+KPEN+ L+D +P PR+KLID A +I ++ G PEF A
Sbjct: 126 GVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVA 185
Query: 2849 PEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVS 2908
PE++ P+ L D+WSIGV+TY++LSG SPFL E+K+ET N+ V++ F EYF S
Sbjct: 186 PEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTS 245
Query: 2909 NAARDFINVILQEDFRRRPTAATCLQHPWLQ 2939
A+DFI +L +D +RR T A L+H W++
Sbjct: 246 ELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 276
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 231 bits (588), Expect = 1e-59
Identities = 152/487 (31%), Positives = 240/487 (49%), Gaps = 26/487 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P+ L + V L G+ V ++ G+P P ITW+ Q+++D + S S
Sbjct: 31028 PKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQ-KGQDLIDNNGHYQVIVTRSFTS-- 31084
Query: 2531 ITLKICN-LMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRW 2589
L N + +D+G Y A N G + + V VP P + S SV L W
Sbjct: 31085 --LVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTW 31142
Query: 2590 LPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG 2649
P+S G I+ Y VE ++ W + V +T + +L YQFRV A N +G
Sbjct: 31143 TEPASDGGSKITNYIVEKCATTAERWLR-VGQARETRYTVINLFGKTSYQFRVIAENKFG 31201
Query: 2650 ISLPSEPSE-------FVRLPEYDAAAD---------GATISWKENFDSAYTELNEIGRG 2693
+S PSEPSE R YD D + S KE ++ Y ++GRG
Sbjct: 31202 LSKPSEPSEPTITKEDKTRAMNYDEEVDETREVSMTKASHSSTKELYEK-YMIAEDLGRG 31260
Query: 2694 RFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSY 2753
F IV +C+ +++K KFV K + E ++L +H + LH+++ES
Sbjct: 31261 EFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISILNIARHRNILHLHESFESMEEL 31320
Query: 2754 ILILELMDDGRLLDYLMNHD-ELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLID 2812
++I E + + + + EL E ++ Y+ + EALQ+LH+ + H DI+PEN++
Sbjct: 31321 VMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHFDIRPENIIYQ 31380
Query: 2813 LRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYV 2872
R +K+I+ A Q+ + L PE+ APEV Q VS TD+WS+G L YV
Sbjct: 31381 TRRS-STIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDMWSLGTLVYV 31439
Query: 2873 MLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATC 2932
+LSG++PFL E+ ++ N+ +++F E F +S A DF++ +L ++ + R TA+
Sbjct: 31440 LLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSRMTASEA 31499
Query: 2933 LQHPWLQ 2939
LQHPWL+
Sbjct: 31500 LQHPWLK 31506
Score = 101 bits (251), Expect = 1e-20
Identities = 68/214 (31%), Positives = 93/214 (43%), Gaps = 18/214 (8%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLM 2539
+TC G + + GRP P +TWK + + +TD S T T TL + + M
Sbjct: 28657 ITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTT-----KDRTTLTVKDSM 28711
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPI-AQERSCTSVILRWLPPSSTGNC 2598
DSG Y N G + S TV V G P PI S S +L W P G
Sbjct: 28712 RGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIEVSSVSAESCVLSWGEPKDGGGT 28771
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE--- 2655
I+ Y VE RE G+ WQ +S T + + L+ Y FRVS+ N +G+S P E
Sbjct: 28772 EITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAP 28831
Query: 2656 ---------PSEFVRLPEYDAAADGATISWKENF 2680
PS R Y +A+ +I W+E +
Sbjct: 28832 IIAEHPFVPPSAPTRPEVYHVSANAMSIRWEEPY 28865
Score = 97.4 bits (241), Expect = 2e-19
Identities = 68/211 (32%), Positives = 89/211 (42%), Gaps = 26/211 (12%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
GD + ++ V GRPKPT+TWK DQ + T + T +S L I + DSG
Sbjct: 21080 GDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATST-----ILNINECVRSDSG 21134
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTISGY 2603
Y A N G T++V +P P PI E S V W PP + G IS Y
Sbjct: 21135 PYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNY 21194
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI------------- 2650
VE R+ S W + + + T L+ G YQFRV A N +G+
Sbjct: 21195 VVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANY 21254
Query: 2651 --SLPSEPSEFVRLPEYDAAA-DGATISWKE 2678
+P P P+ A D TISW E
Sbjct: 21255 PFKVPGPPG----TPQVTAVTKDSMTISWHE 21281
Score = 94.4 bits (233), Expect = 2e-18
Identities = 59/186 (31%), Positives = 85/186 (45%), Gaps = 6/186 (3%)
Query: 2469 VAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDS 2528
+ P +P + G+ + ++ V GRP+P I+W + + T + T +S
Sbjct: 24310 IQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATST-- 24367
Query: 2529 GEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVIL 2587
L I D G YT ATN GT + + +V V P P P+ E S V++
Sbjct: 24368 ---VLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVI 24424
Query: 2588 RWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNP 2647
W PP+ TG C IS Y VE R+ + W A+ T + I L G YQFR+ A N
Sbjct: 24425 SWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENR 24484
Query: 2648 WGISLP 2653
+G S P
Sbjct: 24485 YGKSAP 24490
Score = 92.0 bits (227), Expect = 8e-18
Identities = 64/202 (31%), Positives = 91/202 (45%), Gaps = 17/202 (8%)
Query: 2487 TVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIY 2546
T+ L + GRP+P + W+ + + D T S L I N+ DSG Y
Sbjct: 25124 TLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVT-------SSFTMLVIDNVTRFDSGRY 25176
Query: 2547 TCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVE 2606
N+ G+ + V+V P+AP +E SV L W PP G I+ Y VE
Sbjct: 25177 NLTLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVE 25236
Query: 2607 YREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE-- 2664
RE + + + T IE+L GC Y FRV ASN +GI LP+E +E V++ E
Sbjct: 25237 KRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPP 25296
Query: 2665 --------YDAAADGATISWKE 2678
D + ATI W++
Sbjct: 25297 LPPGRVTLVDVTRNTATIKWEK 25318
Score = 91.7 bits (226), Expect = 1e-17
Identities = 61/196 (31%), Positives = 83/196 (42%), Gaps = 27/196 (13%)
Query: 2496 GRPKPTITWKGPDQNI-----LDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIA 2550
GRP PT W PD N+ + T +S +T TV +C+ D+G YT
Sbjct: 28383 GRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRN------------DAGKYTLTV 28430
Query: 2551 TNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREE 2610
N+ G+ S + TVKV P P ++ + S L W P G I Y VE RE
Sbjct: 28431 ENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKREA 28490
Query: 2611 GSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV---------- 2660
+ WQ + DL+ G PY FRVSA N +G+ P E E +
Sbjct: 28491 SRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPR 28550
Query: 2661 RLPEYDAAADGATISW 2676
RL D + A ++W
Sbjct: 28551 RLDVVDTSKSSAVLAW 28566
Score = 90.5 bits (223), Expect = 2e-17
Identities = 85/288 (29%), Positives = 125/288 (43%), Gaps = 34/288 (11%)
Query: 2414 VENTGKNEAT----GPRKPKDILGNKV---SVKETNSSEESECDDLDPNTSMEILNPNFI 2466
VE GK E T G K +I +++ SV E ++E DP T + P +
Sbjct: 27499 VERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVT----IGPITV 27554
Query: 2467 QE--VAPEFL---VPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATY 2521
+E + PE +P VT +G V L+ G+PKP+I+W + +++ +
Sbjct: 27555 KELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESE-----F 27609
Query: 2522 TVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QER 2580
S +ITL I N + G YT I N + TV G P+ P PI E
Sbjct: 27610 VRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKGPIRFDEI 27669
Query: 2581 SCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQF 2640
SVIL W P G I+ Y++E RE W+ +S T + +L YQF
Sbjct: 27670 KADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQF 27729
Query: 2641 RVSASNPWGISLPSEPSEFV-----RLPE-------YDAAADGATISW 2676
RV A N +G+S P S V R+P Y+ +DG +++W
Sbjct: 27730 RVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSLTW 27777
Score = 88.6 bits (218), Expect = 8e-17
Identities = 60/195 (30%), Positives = 85/195 (43%), Gaps = 9/195 (4%)
Query: 2468 EVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTD--NSSATYTVSS 2525
E+ P +P + + + GRP+ T+ W+ Q + +T N S++ TV+S
Sbjct: 25392 EIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTS 25451
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSV 2585
L I +D G Y +N G+ + T+ V P P E SC S+
Sbjct: 25452 -------LSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSI 25504
Query: 2586 ILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSAS 2645
+ W PP G C IS Y VE +E S W + T + I L+ G YQFRV A
Sbjct: 25505 TISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAE 25564
Query: 2646 NPWGISLPSEPSEFV 2660
N +G S SE S V
Sbjct: 25565 NRYGKSSYSESSAVV 25579
Score = 88.2 bits (217), Expect = 1e-16
Identities = 101/420 (24%), Positives = 157/420 (37%), Gaps = 60/420 (14%)
Query: 2422 ATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSM-EILNPNFIQEVAPEFLVPLVDV 2480
ATG + ++ N S SE D P T + E + P VA + L+
Sbjct: 19253 ATGLEEKAQYQFRAIARTAVNISPPSEPSD--PVTILAENVPPRIDLSVAMKSLL----- 19305
Query: 2481 TCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMP 2540
T G V L V G+P PT++WK + + + C TL++ ++
Sbjct: 19306 TVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLC-----TLELFSVNR 19360
Query: 2541 QDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTI 2600
+DSG YT A N G+ S + +KV P P + +L W PP G I
Sbjct: 19361 KDSGDYTITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEI 19420
Query: 2601 SGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
+ Y V+ RE W Q A+ T +E L G YQFR+ A N +G+ P +
Sbjct: 19421 TNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAI 19480
Query: 2661 RLPEYD------------AAADGATISWKENFDSA------------------YTELNEI 2690
YD D T+SWK D +T++N
Sbjct: 19481 AKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRK 19540
Query: 2691 GRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQH----PQYITLHDT 2746
++ + + T + V ++K K A +AA + Q+ P + ++DT
Sbjct: 19541 PIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDT 19600
Query: 2747 YESPTSYILILELMDDGR-LLDYLM-----NHDELME-------EKVAFYIRDIMEALQY 2793
S S D G ++ YL+ + D + +K F + +ME QY
Sbjct: 19601 TRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQY 19660
Score = 87.8 bits (216), Expect = 1e-16
Identities = 60/202 (29%), Positives = 88/202 (43%), Gaps = 17/202 (8%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G ++ L + GRP P + W D I D T + +S L + N+ DSG
Sbjct: 22957 GGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTS-------LVLDNVNRYDSG 23009
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
YT N GT S TV+V P+ P E + SV + W PP G I Y
Sbjct: 23010 KYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYI 23069
Query: 2605 VEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
VE RE + + V + I+ L GC Y FRV+A N +GI LP++ ++ +++ E
Sbjct: 23070 VEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAE 23129
Query: 2665 Y----------DAAADGATISW 2676
D + ++SW
Sbjct: 23130 VPQPPGKITVDDVTRNSVSLSW 23151
Score = 87.4 bits (215), Expect = 2e-16
Identities = 61/204 (29%), Positives = 89/204 (43%), Gaps = 21/204 (10%)
Query: 2487 TVILQCKVCGRPKPTITWKGPDQNILDTDN--SSATYTVSSCDSGEITLKICNLMPQDSG 2544
T+ L + GRP P + W LD + S+++YT+ L + N+ DSG
Sbjct: 21877 TLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTL---------LIVGNVNRFDSG 21927
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
Y N G+ S V+V P P +E + TSV L W PP G I Y
Sbjct: 21928 KYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYI 21987
Query: 2605 VEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
VE RE + + + T ++ L GC Y FRV A N +GI LP+E +E V+ E
Sbjct: 21988 VEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASE 22047
Query: 2665 ----------YDAAADGATISWKE 2678
D + ++SW++
Sbjct: 22048 RPLPPGKITLMDVTRNSVSLSWEK 22071
Score = 85.5 bits (210), Expect = 7e-16
Identities = 74/282 (26%), Positives = 117/282 (41%), Gaps = 36/282 (12%)
Query: 2453 DPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVC--------GRPKPTITW 2504
DP+ S + P +E E PL D+ + T+I++ GRP P + W
Sbjct: 26167 DPSDSSD---PQIAKEREEE---PLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLW 26220
Query: 2505 KGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVK 2564
PD TD + Y V + DS +L I N DSG YT N S + VK
Sbjct: 26221 SKPD-----TDLRTRAY-VDTTDS-RTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVK 26273
Query: 2565 VQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLD 2624
V P P Q+ + S +L W P + G + Y +E RE + W +
Sbjct: 26274 VLDTPGPPTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNR 26333
Query: 2625 TYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDA----------AADGATI 2674
+ +L G Y FRVS N +G+ +P+E E V++ E + + D ++
Sbjct: 26334 LSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSL 26393
Query: 2675 SW-KENFDS----AYTELNEIGRGRFSIVKKCIHKATRKDVA 2711
+W K D + + + +G+ + VK + K+T V+
Sbjct: 26394 TWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVS 26435
Score = 85.1 bits (209), Expect = 9e-16
Identities = 64/238 (26%), Positives = 100/238 (42%), Gaps = 10/238 (4%)
Query: 2484 LGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEIT-LKICNLMPQD 2542
+G + ++ + GRPKPTITW + T + T DS ++T L I D
Sbjct: 23243 VGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVT------DSLDLTTLSIKETHKDD 23296
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTIS 2601
G Y N G + S + P P P+ + S S+ L W PP TG C I+
Sbjct: 23297 GGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQIT 23356
Query: 2602 GYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV- 2660
Y V+ R+ + +W A+ T L + L G YQFR+ A N +G S E V
Sbjct: 23357 NYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVA 23416
Query: 2661 RLPEYDAAADGATISWKENFDSAYTELNE-IGRGRFSIVKKCIHKATRKDVAVKFVSK 2717
+ P + G + + DS + +E + G ++ + + R + V+K
Sbjct: 23417 QYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNK 23474
Score = 84.7 bits (208), Expect = 1e-15
Identities = 64/201 (31%), Positives = 84/201 (41%), Gaps = 15/201 (7%)
Query: 2485 GDTVILQCKVCGRPKPTITW-----KGPDQN--ILDTDNSSATYTVSSCDSGEITLKICN 2537
G V + K+ G P PT+TW K PD +L + + +C TL I
Sbjct: 16131 GTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTC-----TLVIPQ 16185
Query: 2538 LMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTSVILRWLPPSSTG 2596
D+G+YT A N+ GT S + V G P P PI E S + L W PP G
Sbjct: 16186 SRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDG 16245
Query: 2597 NCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP--S 2654
I+ Y +E RE + W + + I L G Y FR+ A N +GI P S
Sbjct: 16246 GSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDS 16305
Query: 2655 EPSEFVRLPEYDAAADGATIS 2675
EP L A D T+S
Sbjct: 16306 EPETARNLFSVPGAPDKPTVS 16326
Score = 84.0 bits (206), Expect = 2e-15
Identities = 54/171 (31%), Positives = 82/171 (47%), Gaps = 10/171 (5%)
Query: 2490 LQCKVCGRPKPTITWK-GPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTC 2548
L+ + G+P P+++WK G D DT S + V++ TL + + D+G YT
Sbjct: 20002 LKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNT------TLIVYDCQKSDAGKYTI 20055
Query: 2549 IATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTISGYTVEY 2607
N GT + ++KV G P P PI E + ++ L+W PP G I+ Y +E
Sbjct: 20056 TLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEK 20115
Query: 2608 REEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI--SLPSEP 2656
R+ + W ++ T + L G Y FRVSA N +G+ L SEP
Sbjct: 20116 RDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEP 20166
Score = 84.0 bits (206), Expect = 2e-15
Identities = 77/295 (26%), Positives = 119/295 (40%), Gaps = 24/295 (8%)
Query: 2398 KKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTS 2457
K S W T K E TG I G + S + + +E+ D S
Sbjct: 22090 KGSDKWATCATVKVTEATITGL-----------IQGEEYSFRVSAQNEKGISDPRQ--LS 22136
Query: 2458 MEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNS 2517
+ ++ + + + P F + T L G+ + + GRP P +TW + + T
Sbjct: 22137 VPVIAKDLV--IPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRV 22194
Query: 2518 SATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA 2577
+A T ++ L I + +D G Y TN G + V V P P P+
Sbjct: 22195 NAESTENNS-----LLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVK 22249
Query: 2578 QER-SCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGC 2636
+ + S+ L W PP G +I+ Y VE R+ + WQ A+ T + L GC
Sbjct: 22250 MDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGC 22309
Query: 2637 PYQFRVSASNPWGIS--LPSEPSEFVRLPEYDAAADGATISWKENFDSAYTELNE 2689
YQFR++A N +G S L SEP+ + P G + + DS + NE
Sbjct: 22310 EYQFRIAAENRYGKSTYLNSEPT-VAQYPFKVPGPPGTPVVTLSSRDSMEVQWNE 22363
Score = 83.6 bits (205), Expect = 3e-15
Identities = 64/209 (30%), Positives = 93/209 (44%), Gaps = 17/209 (8%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G+ V + GRP PT+TW+ ++N+ S A Y++ + DS + L I + D+G
Sbjct: 27286 GEDVQVLIPFKGRPPPTVTWRKDEKNL----GSDARYSIENTDSSSL-LTIPQVTRNDTG 27340
Query: 2545 IYTCIATNDHGTT-STSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
Y N G S++ +VKV PAA + + S +V L W PP G I Y
Sbjct: 27341 KYILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINY 27400
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLP 2663
+E R+ + W T + DLS P+ FRV A N GI P E +E V+
Sbjct: 27401 VIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAA 27460
Query: 2664 EY----------DAAADGATISW-KENFD 2681
E D+ +SW K +FD
Sbjct: 27461 EVPAPIRDLSMKDSTKTSVILSWTKPDFD 27489
Score = 83.2 bits (204), Expect = 4e-15
Identities = 65/227 (28%), Positives = 90/227 (39%), Gaps = 20/227 (8%)
Query: 2470 APEFLVP---LVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
APE + L +T G + L V G+P+P ITW D IL D V
Sbjct: 13687 APEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADM-ILKQDKRITIENVPK- 13744
Query: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVI 2586
+ T+ I + D+G Y A N G + V V P P + + S +
Sbjct: 13745 ---KSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCL 13801
Query: 2587 LRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASN 2646
L W PP G I+ Y VE R S++W + ++ DT L P Y FRV+A N
Sbjct: 13802 LTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAEN 13861
Query: 2647 PWGISLPSE------------PSEFVRLPEYDAAADGATISWKENFD 2681
+G+ P + P RL D D T++W E D
Sbjct: 13862 MYGVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDD 13908
Score = 82.8 bits (203), Expect = 5e-15
Identities = 67/221 (30%), Positives = 91/221 (41%), Gaps = 18/221 (8%)
Query: 2480 VTCLLGDTVILQC-KVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNL 2538
+T GDT++L + G+P P +W ++I +D + T T +S +T+K
Sbjct: 20388 LTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS---SMLTIKYATR 20444
Query: 2539 MPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNC 2598
+D+G YT ATN GT V V VP P S L W PP G
Sbjct: 20445 --KDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGS 20502
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP--SEP 2656
I Y +E RE +W V L G Y FRVSA N +G P SEP
Sbjct: 20503 PIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEP 20562
Query: 2657 SEFV---------RLPEY-DAAADGATISWKENFDSAYTEL 2687
+ V PE + + AT+SWK D +E+
Sbjct: 20563 VKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEI 20603
Score = 82.4 bits (202), Expect = 6e-15
Identities = 57/234 (24%), Positives = 101/234 (43%), Gaps = 18/234 (7%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLM 2539
+T +G+ L + G+PKP ++W + ++L+ D + T ++ +I K
Sbjct: 16828 LTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAK----- 16882
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNC 2598
DSG Y + N G+ V V P P P++ E + +++ W PP G
Sbjct: 16883 RSDSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVTKDYMVISWKPPLDDGGS 16942
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP----- 2653
I+ Y +E +E G +W +++ T + L G Y FR+ A N +GIS P
Sbjct: 16943 KITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDS 17002
Query: 2654 SEPSEFVRLPE-------YDAAADGATISWKENFDSAYTELNEIGRGRFSIVKK 2700
+ + R+P+ + D A ++W + D N I R ++ K+
Sbjct: 17003 MKAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKPITNYILEKRETMSKR 17056
Score = 80.5 bits (197), Expect = 2e-14
Identities = 60/199 (30%), Positives = 88/199 (44%), Gaps = 8/199 (4%)
Query: 2467 QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
Q + P+ L+P +T G + ++ V G+P PT WK + ++ +S+ V
Sbjct: 18896 QLLPPKILMP-EQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVV----TSSHLAVHKA 18950
Query: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPI-AQERSCTSV 2585
DS I L I ++ +DSG Y+ A N GT + V V P P P + +
Sbjct: 18951 DSSSI-LIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADAC 19009
Query: 2586 ILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSAS 2645
L W P G I+ Y VE + W ++AS T + L PG Y FRV A
Sbjct: 19010 SLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAE 19069
Query: 2646 NPWGISLP-SEPSEFVRLP 2663
N +GIS P + P + P
Sbjct: 19070 NRFGISEPLTSPKMVAQFP 19088
Score = 78.2 bits (191), Expect = 1e-13
Identities = 63/207 (30%), Positives = 92/207 (44%), Gaps = 22/207 (10%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSA-TYT-VSSCDSGEITLKICNLMPQD 2542
G V L + GRP P +W + +++ + T+T V+ E T++ D
Sbjct: 29753 GRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIR-------D 29805
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTIS 2601
+G YT N GTTS + V + P P PI E TS+ + W PP G +S
Sbjct: 29806 TGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLS 29865
Query: 2602 GYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGIS--LPSEPSE- 2658
GY VE R+ W S + L+ G Y FRV+A+N +GI L SE E
Sbjct: 29866 GYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIEC 29925
Query: 2659 --FVRLPE-------YDAAADGATISW 2676
+R+P +D + DG T++W
Sbjct: 29926 RSSIRIPGPPETLQIFDVSRDGMTLTW 29952
Score = 77.0 bits (188), Expect = 3e-13
Identities = 59/204 (28%), Positives = 79/204 (38%), Gaps = 15/204 (7%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G T+ L V GRP P ITW P+ N+ D + S D + L+ N+ D+G
Sbjct: 19708 GVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLD----IKSTDF-DTFLRCENVNKYDAG 19762
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
Y N G + VKV P P +E S S + W PP G I Y
Sbjct: 19763 KYILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYV 19822
Query: 2605 VEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE--------- 2655
V+ R+ + W T + +L G Y FRV A N +GI P E
Sbjct: 19823 VQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQ 19882
Query: 2656 -PSEFVRLPEYDAAADGATISWKE 2678
P V L + +I WK+
Sbjct: 19883 TPGPVVDLKVRSVSKSSCSIGWKK 19906
Score = 77.0 bits (188), Expect = 3e-13
Identities = 61/216 (28%), Positives = 85/216 (39%), Gaps = 17/216 (7%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G+T +L+ + G+P P + W + + +T +A + S + TL + + + D G
Sbjct: 24722 GETFVLEADIRGKPIPDVVWSKDGKELEET---AARMEIKSTIQ-KTTLVVKDCIRTDGG 24777
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTSVILRWLPPSSTGNCTISGY 2603
Y +N GT S TVKV P P P+ + L W PP G IS Y
Sbjct: 24778 QYILKLSNVGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHY 24837
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE-------- 2655
+E RE W Q + L PG Y FRV A N +GI P E
Sbjct: 24838 IIEKRETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACN 24897
Query: 2656 ---PSEFVRLPEYDA-AADGATISWKENFDSAYTEL 2687
P PE A D ++W D TE+
Sbjct: 24898 PYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEI 24933
Score = 76.3 bits (186), Expect = 4e-13
Identities = 54/187 (28%), Positives = 74/187 (39%), Gaps = 3/187 (1%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLM 2539
+T GDT+ L+ V G+P P + W D++ D S + DS + +L
Sbjct: 18211 LTVKAGDTIRLEAGVRGKPFPEVAWT-KDKDATDLTRSPRVKIDTRADSSKFSLT--KAK 18267
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCT 2599
D G Y ATN G+ ATV V P + S + W PP G C
Sbjct: 18268 RSDGGKYVVTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWDPPEDDGGCE 18327
Query: 2600 ISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF 2659
I Y +E E +W A+ L + L G Y FRV A N G P+E
Sbjct: 18328 IQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTESKPV 18387
Query: 2660 VRLPEYD 2666
+ +YD
Sbjct: 18388 IAKTKYD 18394
Score = 75.9 bits (185), Expect = 6e-13
Identities = 60/199 (30%), Positives = 78/199 (39%), Gaps = 14/199 (7%)
Query: 2476 PLVDVTCLLGDTVIL--------QCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCD 2527
P + V DTVIL + V GRP PT+ W + + T A + D
Sbjct: 21459 PKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGT----AKLEIKIAD 21514
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVI 2586
L + +DSG YT ATN G VKV P P P+A E + +
Sbjct: 21515 FST-NLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEKCV 21573
Query: 2587 LRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASN 2646
L W PP G I Y V+ RE W + T L + L G Y FRV A N
Sbjct: 21574 LSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVN 21633
Query: 2647 PWGISLPSEPSEFVRLPEY 2665
+G+ P E + + Y
Sbjct: 21634 KYGVGEPLESEPVLAVNPY 21652
Score = 75.9 bits (185), Expect = 6e-13
Identities = 53/195 (27%), Positives = 76/195 (38%), Gaps = 21/195 (10%)
Query: 2496 GRPKPTITWKGPDQNILDTDN--SSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATND 2553
GRP P ITW + D YT S D N D+G Y N
Sbjct: 24050 GRPTPEITWSREEGEFTDKVQIEKGVNYTQLSID---------NCDRNDAGKYILKLENS 24100
Query: 2554 HGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQ 2613
G+ S TVKV P P +E S L W PP G + Y ++ RE +
Sbjct: 24101 SGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRK 24160
Query: 2614 IWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE--------- 2664
+ + T +E+L+ G Y FRV A N +G+ +P E + V+ E
Sbjct: 24161 AYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVT 24220
Query: 2665 -YDAAADGATISWKE 2678
D + A++ W++
Sbjct: 24221 LTDVSQTSASLMWEK 24235
Score = 75.5 bits (184), Expect = 7e-13
Identities = 52/180 (28%), Positives = 73/180 (40%), Gaps = 18/180 (10%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNI-----LDTDNSSATYTVSSCDSGEITLKICNLM 2539
G + L + G+P P W Q+I + T + + D G
Sbjct: 30151 GGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRG---------- 30200
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTSVILRWLPPSSTGNC 2598
DSG Y + N G + V+V G P +P P+ + SV + W PP+ G
Sbjct: 30201 --DSGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGA 30258
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
I GY +E RE W + T LV++ L Y FRVSA N +GIS P + E
Sbjct: 30259 DILGYILERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEE 30318
Score = 75.1 bits (183), Expect = 1e-12
Identities = 63/237 (26%), Positives = 100/237 (42%), Gaps = 19/237 (8%)
Query: 2454 PNTSMEILNPNFIQEVAPEFLVPLVD-VTCLLGDTVILQCKVCGRPKPTITWKGPDQNIL 2512
P+T++ I + + E V L++ + G TV + G P PT W D + +
Sbjct: 17493 PDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWT-TDGSEI 17551
Query: 2513 DTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAP 2572
TD YTV + D+ L I N + +D+G Y +N G+ + + + V VP P
Sbjct: 17552 KTDEH---YTVET-DNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPP 17607
Query: 2573 NRPI-AQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIED 2631
PI + + + + W PP G + Y VE ++ W + + T L I
Sbjct: 17608 TGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPH 17667
Query: 2632 LSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEY------------DAAADGATISW 2676
L GC Y FRV A N G+ P + + V ++ D + AT+SW
Sbjct: 17668 LQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSW 17724
Score = 74.3 bits (181), Expect = 2e-12
Identities = 62/214 (28%), Positives = 86/214 (40%), Gaps = 27/214 (12%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITW--KGPD---QNILDTDNSSATYTVSSCDSGEITLK 2534
VT G ++ L V GRP P ITW +G D + I+DT S + V +
Sbjct: 29456 VTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNR------ 29509
Query: 2535 ICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSS 2594
D+G YT A N G S + VKV P +E S SV + W P+
Sbjct: 29510 ------YDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTI 29563
Query: 2595 TGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPS 2654
G ++ Y VE RE + ++ T I L G Y FRV N +GI P
Sbjct: 29564 DGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPC 29623
Query: 2655 EPSEFV----------RLPEYDAAADGATISWKE 2678
E S+ V +L D T++W++
Sbjct: 29624 ETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEK 29657
Score = 73.9 bits (180), Expect = 2e-12
Identities = 61/206 (29%), Positives = 83/206 (40%), Gaps = 20/206 (9%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G+T L+ V G+P PTI W D+ I SA + + D + + + + + D G
Sbjct: 23640 GETFRLEADVHGKPLPTIEWLRGDKEI----EESARCEIKNTDFKALLI-VKDAIRIDGG 23694
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTS--VILRWLPPSSTGNCTISG 2602
Y A+N G+ S VKV P P P+ Q TS L W PP G IS
Sbjct: 23695 QYILRASNVAGSKSFPVNVKVLDRPGPPEGPV-QVTGVTSEKCSLTWSPPLQDGGSDISH 23753
Query: 2603 YTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE------- 2655
Y VE RE W + + L + L G Y FR+ A N +G+ P E
Sbjct: 23754 YVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMK 23813
Query: 2656 -----PSEFVRLPEYDAAADGATISW 2676
P L + A D T+ W
Sbjct: 23814 NPFVLPGPPKSLEVTNIAKDSMTVCW 23839
Score = 73.6 bits (179), Expect = 3e-12
Identities = 61/271 (22%), Positives = 100/271 (36%), Gaps = 46/271 (16%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNS-------------------------SA 2519
GD + L + G P PTITW D+N++ + +
Sbjct: 14694 GDEIALDASISGSPYPTITWI-KDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQ 14752
Query: 2520 TYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQE 2579
++ + GE L++ + + D G+Y NDHG TV V P P + ++
Sbjct: 14753 RLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPINFVFED 14812
Query: 2580 RSCTSVILRWLPPSSTGNCTISGYTVEYRE--EGSQIWQQSVASTLDTYLVIEDLSPGCP 2637
TSV+ +W PP G I YT+E ++ + W ++ + L G
Sbjct: 14813 IRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKE 14872
Query: 2638 YQFRVSASNPWGISLPSEPSEFVRLPEY------------DAAADGATISWKENFDSA-- 2683
Y FRV A N +G P V + D ++ + W E D+
Sbjct: 14873 YLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNGSP 14932
Query: 2684 ----YTELNEIGRGRFSIVKKCIHKATRKDV 2710
+ E E+ +S V K + A + +V
Sbjct: 14933 ILGYWLEKREVNSTHWSRVNKSLLNALKANV 14963
Score = 72.8 bits (177), Expect = 5e-12
Identities = 64/221 (28%), Positives = 95/221 (42%), Gaps = 21/221 (9%)
Query: 2444 SEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTC-------LLGDTVILQCKVCG 2496
S E++ DP+ EIL P + F+ P +D++ ++ + + + G
Sbjct: 13367 SAENKAGVSDPS---EILGPLTADDA---FVEPTMDLSAFKDGLEVIVPNPITILVPSTG 13420
Query: 2497 RPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT 2556
P+PT TW D+ +L+T + T+S+ L I D GIYT N T
Sbjct: 13421 YPRPTATWCFGDK-VLETGDRVKMKTLSAYAE----LVISPSERSDKGIYTLKLENRVKT 13475
Query: 2557 TSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQ 2616
S V V P+AP + + SV L W PP G ++GY VE RE + W
Sbjct: 13476 ISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWT 13535
Query: 2617 QSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPS 2657
+ + D + DL G Y F+V A N G P EP+
Sbjct: 13536 KVMDFVTDLEFTVPDLVQGKEYLFKVCARNKCG---PGEPA 13573
Score = 72.8 bits (177), Expect = 5e-12
Identities = 54/180 (30%), Positives = 74/180 (41%), Gaps = 12/180 (6%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G++ + + G+P PTI W DQ + +T A + S D +L + + + DSG
Sbjct: 22558 GESFKVDADIYGKPIPTIQWIKGDQELSNT----ARLEIKSTDFAT-SLSVKDAVRVDSG 22612
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA----QERSCTSVILRWLPPSSTGNCTI 2600
Y A N G S + VKV P P P+ CT L W PP G I
Sbjct: 22613 NYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCT---LAWKPPLQDGGSDI 22669
Query: 2601 SGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
Y VE RE +W A+ + L G Y FR+ A N +G+ P E V
Sbjct: 22670 INYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVV 22729
Score = 72.0 bits (175), Expect = 8e-12
Identities = 44/168 (26%), Positives = 74/168 (44%), Gaps = 6/168 (3%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G + + + G+P P +T + T + T + +T+ + + D+G
Sbjct: 26491 GSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAEN-----LTINLKESVTADAG 26545
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTISGY 2603
Y A N GTT + V P P P+ + + SV L+W PP G ++ Y
Sbjct: 26546 RYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNY 26605
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGIS 2651
+ RE + +W + A+ T + + L+ G YQFR+ A N +GIS
Sbjct: 26606 ILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAENRFGIS 26653
Score = 71.6 bits (174), Expect = 1e-11
Identities = 63/231 (27%), Positives = 91/231 (39%), Gaps = 23/231 (9%)
Query: 2459 EILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSS 2518
EIL P I A + +V C + L V GRP P +TW+ + DN
Sbjct: 18599 EILEPPEIDLDASMRKLVIVRAGC----PIRLFAIVRGRPAPKVTWRK-----VGIDNVV 18649
Query: 2519 ATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQ 2578
V D+ L I N DSG Y+ N G + V+V P +
Sbjct: 18650 RKGQVDLVDTMAF-LVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVS 18708
Query: 2579 ERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPY 2638
+ + TS + W PP + G ++ Y VE RE + W T + +L PG Y
Sbjct: 18709 DVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEY 18768
Query: 2639 QFRVSASNPWGISLP-------------SEPSEFVRLPEYDAAADGATISW 2676
FRV+A N +G +P SEP +L + + AT++W
Sbjct: 18769 YFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAW 18819
Score = 71.6 bits (174), Expect = 1e-11
Identities = 48/177 (27%), Positives = 76/177 (42%), Gaps = 6/177 (3%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G +V L+ + G+P PTI W D+ + ++ ++ D I +K + + +SG
Sbjct: 26887 GTSVKLRAGISGKPAPTIEWYKDDKEL---QTNALVCVENTTDLASILIKDADRL--NSG 26941
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTSVILRWLPPSSTGNCTISGY 2603
Y N G+ S + V++ P P PI + + + L W PP+ G I+ Y
Sbjct: 26942 CYELKLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHY 27001
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
VE RE +W + + + G Y FRV A N +GI P E V
Sbjct: 27002 IVEKRETSRVVWSMVSEHLEECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVV 27058
Score = 71.2 bits (173), Expect = 1e-11
Identities = 67/221 (30%), Positives = 97/221 (43%), Gaps = 29/221 (13%)
Query: 2364 PASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHTLR---MRKRAE------- 2413
P ++H A + GS +A L K +A SS I KS T++ R RAE
Sbjct: 824 PKTEHGYEAS--IAGSAIATLQKELSATSSAQKITKSVKAPTVKPSETRVRAEPTPLPQF 881
Query: 2414 ----VENTGKNEATGPRKPKDILGNKVSVKETNSSEES----ECDDLDPNTSMEILNPNF 2465
+T K+EA G K++ VS+ T EE + + + P
Sbjct: 882 PFADTPDTYKSEA-GVEVKKEV---GVSITGTTVREERFEVLHGREAKVTETARVPAPVE 937
Query: 2466 IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSS 2525
I P + L +VT + G++V L+C + G P PT+TW D I + + T+
Sbjct: 938 IPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF---- 993
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
SG L I +DSG +TC A N+ GT STS + VQ
Sbjct: 994 -QSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 1033
Score = 70.9 bits (172), Expect = 2e-11
Identities = 50/166 (30%), Positives = 69/166 (41%), Gaps = 7/166 (4%)
Query: 2484 LGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDS 2543
+GDT+ L + G P P +TWK D++ T S L+I N +D
Sbjct: 17232 VGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSK-------LEIRNAAHEDG 17284
Query: 2544 GIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
GIY+ N G+ + S V V P P E S L W P G I+ Y
Sbjct: 17285 GIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNY 17344
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG 2649
VE R+ S W A++ + L+ G Y FRV+A N +G
Sbjct: 17345 VVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYG 17390
Score = 70.5 bits (171), Expect = 2e-11
Identities = 61/253 (24%), Positives = 104/253 (41%), Gaps = 24/253 (9%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G + + V G+P PT+TW ++ L + + T +SS ++ I N G
Sbjct: 16539 GGVIRIIAYVSGKPPPTVTWN-MNERTLPQEATIETTAISS------SMVIKNCQRSHQG 16591
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRP-IAQERSCTSVILRWLPPSSTGNCTISGY 2603
+Y+ +A N+ G + V V VP P +A + S L W P G I+ Y
Sbjct: 16592 VYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNY 16651
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF---- 2659
+E RE + W + ++ L G Y FR++A N G+ E SE
Sbjct: 16652 VIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIR 16711
Query: 2660 --VRLPE-------YDAAADGATISWK-ENFDSAYTELNEIGRGRFSIVKKCIHKATRKD 2709
+ +PE + + T++W +D +N + R +K HK T +
Sbjct: 16712 EPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEK-FHKVTNDN 16770
Query: 2710 -VAVKFVSKKMKK 2721
++ K+ K +K+
Sbjct: 16771 LLSRKYTVKGLKE 16783
Score = 68.9 bits (167), Expect = 7e-11
Identities = 63/245 (25%), Positives = 94/245 (38%), Gaps = 36/245 (14%)
Query: 2429 KDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLL---G 2485
K++ + VK N + ESE D T+ EI + +E PE + + CL+ G
Sbjct: 15772 KELRKYRFRVKAVNEAGESEPSD----TTGEIPATDIQEE--PEVFIDIGAQDCLVCKAG 15825
Query: 2486 DTVILQCKVCGRPKPTITWKG---------------PDQNILDTDNSSATYTVSSCDSGE 2530
+ + + GRP P +W+ P+ L+T +S+ + C
Sbjct: 15826 SQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSH 15885
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWL 2590
+G Y+ A N G + + VKV VP P + + S L W
Sbjct: 15886 ------------TGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWK 15933
Query: 2591 PPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI 2650
P G I GY +E R + W + T V+ DL Y FRV A N +GI
Sbjct: 15934 MPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGI 15993
Query: 2651 SLPSE 2655
P E
Sbjct: 15994 GPPVE 15998
Score = 68.6 bits (166), Expect = 9e-11
Identities = 56/181 (30%), Positives = 83/181 (45%), Gaps = 10/181 (5%)
Query: 2484 LGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQD- 2542
+G T+ L GRP P +TW + + +++N + T L + N+ +
Sbjct: 30642 VGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTH-----LVMKNVQRKTH 30696
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSC-TSVILRWLPPSSTGNCTIS 2601
+G Y +N GT V++Q P P PI E S ++ W PP+ G I+
Sbjct: 30697 AGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWIT 30756
Query: 2602 GYTVEYRE--EGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF 2659
Y VE E EG++ WQ ++ T I +L+ Y FRVSA N +GIS P E S
Sbjct: 30757 NYVVEKCEAKEGAE-WQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSV 30815
Query: 2660 V 2660
V
Sbjct: 30816 V 30816
Score = 68.2 bits (165), Expect = 1e-10
Identities = 44/153 (28%), Positives = 70/153 (45%), Gaps = 6/153 (3%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGV-----P 2569
+ S ++T S + + K+ L+P + I+ +A N +G + V P
Sbjct: 24843 ETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPP 24902
Query: 2570 AAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLV 2628
P+ P + S+++ W P G I GY +E R++ W + TL D L
Sbjct: 24903 GPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLR 24962
Query: 2629 IEDLSPGCPYQFRVSASNPWGISLPSEPSEFVR 2661
+ L+ G Y+FRV+A N G+ PSEPS F R
Sbjct: 24963 VTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYR 24995
Score = 67.8 bits (164), Expect = 2e-10
Identities = 67/259 (25%), Positives = 106/259 (40%), Gaps = 29/259 (11%)
Query: 2435 KVSVKETNSSEESECDDLDPNTSMEILNPNFIQ-EVAPEFLVPLVDVTCLLGDTVILQCK 2493
K+ V N++ E + P T E P ++ +V+ + + + + G T+ +
Sbjct: 15073 KLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQI-----MAGKTLRIPAV 15127
Query: 2494 VCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATND 2553
V GRP PT W ++ LD D V + L I + + +D G Y ATN
Sbjct: 15128 VTGRPVPTKVWT-KEEGELDKDR-----VVIDNVGTKSELIIKDALRKDHGRYVITATNS 15181
Query: 2554 HGTTSTSATVKVQGV--PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEG 2611
G+ +A V+V V P +P+ R +L W P G I+G+ +E ++
Sbjct: 15182 CGSKFAAARVEVFDVPGPVLDLKPVVTNRK--MCLLNWSDPEDDGGSEITGFIIERKDAK 15239
Query: 2612 SQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE------------PSEF 2659
W+Q + T + I L G Y+FRV A N +G P E P+
Sbjct: 15240 MHTWRQPI-ETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSP 15298
Query: 2660 VRLPEYDAAADGATISWKE 2678
RL + T+ WKE
Sbjct: 15299 ERLTYTERTKSTITLDWKE 15317
Score = 67.8 bits (164), Expect = 2e-10
Identities = 51/205 (24%), Positives = 85/205 (41%), Gaps = 30/205 (14%)
Query: 2487 TVILQCKVCGRPKP---------------TITWKGPDQN---------ILDTDNSSATYT 2522
+V + CKV +P P +++W P ++ + + S +T
Sbjct: 25872 SVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWT 25931
Query: 2523 VSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG-----VPAAPNRPIA 2577
+ + + K+ L+ + I+ N +G +V ++ VP+ P
Sbjct: 25932 ICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEI 25991
Query: 2578 QERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGC 2636
+ S+ L W P S G ISGY +E RE+ S W + + D + L GC
Sbjct: 25992 TSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGC 26051
Query: 2637 PYQFRVSASNPWGISLPSEPSEFVR 2661
Y++RV A N G+SLPSE S +R
Sbjct: 26052 EYEYRVYAENAAGLSLPSETSPLIR 26076
Score = 67.4 bits (163), Expect = 2e-10
Identities = 52/181 (28%), Positives = 69/181 (38%), Gaps = 5/181 (2%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLM 2539
VT G ++L V G+P+P I W D+ + + S YT + +K C+
Sbjct: 29057 VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATA---VIKFCDR- 29112
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCT 2599
DSG YT N GT + S VKV P + + L W P G
Sbjct: 29113 -SDSGKYTLTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAE 29171
Query: 2600 ISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF 2659
I+ Y VE RE W V+ L Y FRV A N +G +P E
Sbjct: 29172 ITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPI 29231
Query: 2660 V 2660
V
Sbjct: 29232 V 29232
Score = 66.6 bits (161), Expect = 3e-10
Identities = 56/211 (26%), Positives = 88/211 (41%), Gaps = 10/211 (4%)
Query: 2467 QEVAPEFLVPLVDVTCLL---GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTV 2523
+E+AP+F + L+ G ++ + + GRP P +TW + N+ + N T +
Sbjct: 20770 REMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESF 20829
Query: 2524 SSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCT 2583
+ + + CN D+G + N G S V+V P + +
Sbjct: 20830 TL-----LIIPECNRY--DTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKD 20882
Query: 2584 SVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVS 2643
SV L W P G I+ Y VE RE + + + + LS GC Y FRV
Sbjct: 20883 SVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVM 20942
Query: 2644 ASNPWGISLPSEPSEFVRLPEYDAAADGATI 2674
A N +GI P+E +E V+ E + D I
Sbjct: 20943 AENEYGIGEPTETTEPVKASEAPSPPDSLNI 20973
Score = 66.2 bits (160), Expect = 5e-10
Identities = 43/130 (33%), Positives = 65/130 (50%), Gaps = 12/130 (9%)
Query: 2469 VAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDS 2528
V P F+ L DV +LG +V+L+C+V G ++ W I+ ++++ + C
Sbjct: 6739 VPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVC-- 6796
Query: 2529 GEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQE------RSC 2582
TL + L P D+GIYTC+A N G+ SA + VQ P+ P + E +
Sbjct: 6797 ---TLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTF 6853
Query: 2583 TSVILRWLPP 2592
TSVI R PP
Sbjct: 6854 TSVI-RGTPP 6862
Score = 65.9 bits (159), Expect = 6e-10
Identities = 55/212 (25%), Positives = 90/212 (42%), Gaps = 18/212 (8%)
Query: 2479 DVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNL 2538
D+ + G+ + + P PT++W + + +D + D L++
Sbjct: 14395 DIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKN-----DHISAHLEVPKS 14449
Query: 2539 MPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNC 2598
+ D+GIYT N G+ + S VKV G+P A + + +S L W PP G
Sbjct: 14450 VRADAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGT 14509
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG----ISL-- 2652
I Y +E RE G + + ++ ++DL P Y FRV A N G I L
Sbjct: 14510 PILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKN 14569
Query: 2653 ------PSEPSE-FVRLPEYDAAADGATISWK 2677
P +P + V + ++ A+ TI+WK
Sbjct: 14570 PVIAQDPKQPPDPPVDVEVHNPTAEAMTITWK 14601
Score = 65.5 bits (158), Expect = 8e-10
Identities = 46/138 (33%), Positives = 68/138 (49%), Gaps = 8/138 (5%)
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTS--TSATVKVQG---VPAAPNRPIAQERSC 2582
S + T K+ L+ I+ A N +G + S ++K + VP AP++PI E +
Sbjct: 16966 SAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTK 17025
Query: 2583 TSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLV--IEDLSPGCPYQF 2640
S ++ W P G I+ Y +E RE S+ W + + Y + DL GC Y+F
Sbjct: 17026 DSALVTWNKPHDGGK-PITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEF 17084
Query: 2641 RVSASNPWGISLPSEPSE 2658
RVSA N GI PS PS+
Sbjct: 17085 RVSAENEIGIGDPSPPSK 17102
Score = 65.5 bits (158), Expect = 8e-10
Identities = 46/173 (26%), Positives = 76/173 (43%), Gaps = 15/173 (8%)
Query: 2501 TITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIAT 2551
T+ W+ P + +L + S+A +T S +K+ L + + A
Sbjct: 26588 TLKWEPPKYDGGSQVTNYILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAE 26647
Query: 2552 NDHGTT----STSATVKVQ-GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVE 2606
N G + S TVK+ P P+ P + S+ + W P S G + GY +E
Sbjct: 26648 NRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSAVVGYHLE 26707
Query: 2607 YREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
++ S +WQ++ + T+ + +S G Y+FRV A N G+ PS PSE
Sbjct: 26708 MKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSHPSE 26760
Score = 65.1 bits (157), Expect = 1e-09
Identities = 46/171 (26%), Positives = 74/171 (43%), Gaps = 5/171 (2%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILD--TDNSSATYTVSSCDSGEITLKICNLMPQD 2542
G+ V + V G P P I W ++ +++ TD T S + L I + +D
Sbjct: 15413 GEPVHIPADVTGLPMPKIEWS-KNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVRED 15471
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISG 2602
G YT A+N G+ + V+V P+ P + S L W P G I+
Sbjct: 15472 KGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAPLDNGGSEITH 15531
Query: 2603 YTVEYREEGSQ--IWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGIS 2651
Y ++ R+ + W++ + ++ I L P Y+FRV A N +GIS
Sbjct: 15532 YVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGIS 15582
Score = 64.7 bits (156), Expect = 1e-09
Identities = 53/183 (28%), Positives = 75/183 (40%), Gaps = 30/183 (16%)
Query: 2502 ITWKGPDQNILDTDNSSAT-YTVSSCDSG-------EIT-------LKICNLMPQDSGIY 2546
+TW P LD S T Y + D+ E+T I L+P +
Sbjct: 15516 LTWDAP----LDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEF 15571
Query: 2547 TCIATNDHGTTSTSATVKV-----QGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTIS 2601
A N +G + + KV +P P +P R+ S+++ W PP G I+
Sbjct: 15572 RVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPIT 15631
Query: 2602 GYTVEYREEGSQIWQQSVASTL------DTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
GY +E REEGS W + + + + L G YQFR A N GI PSE
Sbjct: 15632 GYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSE 15691
Query: 2656 PSE 2658
PS+
Sbjct: 15692 PSD 15694
Score = 64.7 bits (156), Expect = 1e-09
Identities = 31/91 (34%), Positives = 49/91 (53%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYL 2627
+P+ P++P + T++ + W+ P G I+GYTVEY++ W+ S+ S T
Sbjct: 26083 LPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEY 26142
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
I L+ G Y FRV + N G S PS+ S+
Sbjct: 26143 TISGLTTGAEYVFRVKSVNKVGASDPSDSSD 26173
Score = 64.3 bits (155), Expect = 2e-09
Identities = 36/108 (33%), Positives = 54/108 (50%), Gaps = 1/108 (0%)
Query: 2558 STSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ 2617
S AT + P P P + + +S L W PP G ++GY VEY+EEG + W++
Sbjct: 16410 SDPATARDPIAPPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEK 16469
Query: 2618 SVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
+ T LV+ L G Y+FRV A N GI P E ++ + + +
Sbjct: 16470 GKDKEVRGTKLVVTGLKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKD 16517
Score = 64.3 bits (155), Expect = 2e-09
Identities = 46/172 (26%), Positives = 72/172 (41%), Gaps = 6/172 (3%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G+ + + + GRP P I+W ++ ++ + + T +S+ + +T+K C + +D+G
Sbjct: 25804 GEVLKINADIAGRPLPVISWA---KDGIEIEERARTEIISTDNHTLLTVKDC--IRRDTG 25858
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPI-AQERSCTSVILRWLPPSSTGNCTISGY 2603
Y N GT S + KV P P P+ + L W P G I Y
Sbjct: 25859 QYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYY 25918
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
VE RE W T + L G Y FRV+ N +G+ P E
Sbjct: 25919 IVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLE 25970
Score = 63.5 bits (153), Expect = 3e-09
Identities = 68/267 (25%), Positives = 107/267 (40%), Gaps = 32/267 (11%)
Query: 2466 IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSS 2525
I E PE+ L+ + G+++ ++ V GRP P +TW I N T +
Sbjct: 27957 IVEFGPEYFDGLIIKS---GESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVL-- 28011
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTS 2584
G +L + + G+YT A N G+ VKVQ P PI +
Sbjct: 28012 ---GSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEK 28068
Query: 2585 VILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVS 2643
+ L W P + G I+ Y +E RE W +Y I+ L G YQFRVS
Sbjct: 28069 MTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIK-LINGNEYQFRVS 28127
Query: 2644 ASNPWGISLPSEPSEFVRLPEY------------DAAADGATISWKENFDSAYTELNEIG 2691
A N +G+ P + V +Y + + T++W +E+ +
Sbjct: 28128 AVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQY- 28186
Query: 2692 RGRFSIVKKCIHKATRKDVAVKFVSKK 2718
I+++ K+TR VK +SK+
Sbjct: 28187 -----ILERREKKSTR---WVKVISKR 28205
Score = 63.5 bits (153), Expect = 3e-09
Identities = 49/185 (26%), Positives = 78/185 (42%), Gaps = 18/185 (9%)
Query: 2499 KPTITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
K T+ W P ++ + + S + + + ++ + L+ + I+
Sbjct: 29156 KCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVR 29215
Query: 2550 ATNDHGTTSTSATVKVQG-----VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
A N +G + + +P+ P P +I++W P S G IS Y
Sbjct: 29216 AVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYL 29275
Query: 2605 VEYREEGSQIWQQSVASTL--DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV-- 2660
V+ RE+ S W + + DT L + L GC YQFRV+A N G S PSE S F+
Sbjct: 29276 VDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISC 29335
Query: 2661 RLPEY 2665
R P Y
Sbjct: 29336 REPSY 29340
Score = 62.8 bits (151), Expect = 5e-09
Identities = 51/181 (28%), Positives = 79/181 (43%), Gaps = 15/181 (8%)
Query: 2499 KPTITWKGPDQN--------ILDT-DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
K T+TW P ++ IL+ + S +TV S D L+ + I+
Sbjct: 20488 KATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVS 20547
Query: 2550 ATNDHGTTSTSATVKVQ-----GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
A N +G + V+ G P P +P + + + W P G I+GY
Sbjct: 20548 AVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYH 20607
Query: 2605 VEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLP 2663
VE RE+ S W +++ + + D + L G Y+FRVSA N GI PSE S+ V +
Sbjct: 20608 VERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMK 20667
Query: 2664 E 2664
+
Sbjct: 20668 D 20668
Score = 62.4 bits (150), Expect = 7e-09
Identities = 62/234 (26%), Positives = 94/234 (40%), Gaps = 25/234 (10%)
Query: 2426 RKPKDILGN--KVSVKETNSSEESECDDLDPNT-SMEILNPNFIQEVAPEFLVPLVDVTC 2482
R P I GN + +K N E E +L + + +IL+P ++ +DVTC
Sbjct: 17865 RVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVE----------LDVTC 17914
Query: 2483 L------LGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKIC 2536
+G T+ + +V GRP+P ITW + ++ D + L+I
Sbjct: 17915 RDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQ-----DLPRVELQIK 17969
Query: 2537 NLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTG 2596
+ D G Y A N G SA V V P + + + W P G
Sbjct: 17970 EAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVTKENCTISWENPLDNG 18029
Query: 2597 NCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI 2650
I+ + VEYR+ + W VAS + L+ +L Y FRV A N G+
Sbjct: 18030 GSEITNFIVEYRKPNQKGW-SIVASDVTKRLIKANLLANNEYYFRVCAENKVGV 18082
Score = 62.4 bits (150), Expect = 7e-09
Identities = 51/200 (25%), Positives = 81/200 (40%), Gaps = 25/200 (12%)
Query: 2502 ITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATN 2552
++W P+ N I + S + + T K+ NL+ + A N
Sbjct: 27676 LSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAEN 27735
Query: 2553 DHGTT----STSATVKVQ-GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEY 2607
+G + S+ K Q +P P +P+ + + L W P G ++G+ VE
Sbjct: 27736 RYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEK 27795
Query: 2608 REEGSQIWQQSVASTLD-TYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV------ 2660
+E S +WQ+ S + L G YQFRV A N G+S PS+PS+F
Sbjct: 27796 KERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPV 27855
Query: 2661 ---RLPEY-DAAADGATISW 2676
P+Y D + T+ W
Sbjct: 27856 DPPGTPDYIDVTRETITLKW 27875
Score = 62.4 bits (150), Expect = 7e-09
Identities = 38/111 (34%), Positives = 56/111 (50%), Gaps = 6/111 (5%)
Query: 2470 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG 2529
AP + DVT LG+ L C++ GRP P I W + ++ S Y +SS D
Sbjct: 30532 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ----SRKYKMSS-DGR 30586
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPA-APNRPIAQE 2579
TL + +D G+YTCIATN+ G TS+ + +Q P P P+ ++
Sbjct: 30587 THTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEK 30637
Score = 62.0 bits (149), Expect = 8e-09
Identities = 45/150 (30%), Positives = 67/150 (44%), Gaps = 6/150 (4%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTS---TSATVKVQG--VP 2569
D S+ T+ + S T+K C L + A N +G ++ + TV VP
Sbjct: 22282 DTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVP 22341
Query: 2570 AAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLV 2628
P P+ S S+ ++W P S G + GY +E +E S +W + + + T
Sbjct: 22342 GPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFK 22401
Query: 2629 IEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
L G Y+FRVSA N GI PS+ SE
Sbjct: 22402 TTGLEEGVEYEFRVSAENIVGIGKPSKVSE 22431
Score = 61.6 bits (148), Expect = 1e-08
Identities = 36/104 (34%), Positives = 51/104 (49%), Gaps = 3/104 (2%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLV 2628
PA P R + S +S +L WL P G I+GY +E R++GS W ++ T
Sbjct: 28546 PAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEA-GHTKQLTFT 28604
Query: 2629 IEDLSPGCPYQFRVSASNPWGISLPSE--PSEFVRLPEYDAAAD 2670
+E L Y+FRV A N G S P E S ++ P+ + AD
Sbjct: 28605 VERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTAD 28648
Score = 61.2 bits (147), Expect = 1e-08
Identities = 42/143 (29%), Positives = 64/143 (44%), Gaps = 7/143 (4%)
Query: 2520 TYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ------GVPAAPN 2573
T++ + + + + + NL+P + + A N++G + K P P
Sbjct: 18744 TWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPR 18803
Query: 2574 RPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLVIEDL 2632
+ E + S L WLPP G I GY YREE + + S + D LV+ L
Sbjct: 18804 KLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGL 18863
Query: 2633 SPGCPYQFRVSASNPWGISLPSE 2655
G Y+FRV+A N G+SLP E
Sbjct: 18864 KEGKKYKFRVAARNAVGVSLPRE 18886
Score = 61.2 bits (147), Expect = 1e-08
Identities = 47/189 (24%), Positives = 82/189 (43%), Gaps = 9/189 (4%)
Query: 2520 TYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPI 2576
+Y+ ++ + T K+ L + +A N++G T T+ VK P+ P+
Sbjct: 20913 SYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLN 20972
Query: 2577 AQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGC 2636
+ + ++V L W P G I+GY +E + +GS W + + V+ +L+ G
Sbjct: 20973 IMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTH-ITTVKGLECVVRNLTEGE 21031
Query: 2637 PYQFRVSASNPWGISLPSEP-----SEFVRLPEYDAAADGATISWKENFDSAYTELNEIG 2691
Y F+V A N G S P E E LPE D + + D+ E+ +G
Sbjct: 21032 EYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLG 21091
Query: 2692 RGRFSIVKK 2700
R + ++ K
Sbjct: 21092 RPKPTVTWK 21100
Score = 61.2 bits (147), Expect = 1e-08
Identities = 41/135 (30%), Positives = 60/135 (44%), Gaps = 6/135 (4%)
Query: 2533 LKICNLMPQDSGIYTCIATNDHGT-----TSTSATVKVQGVPAAPNRPIAQERSCTSVIL 2587
LK+ L+ + I+ +A N +G + V G P P P + S+++
Sbjct: 21614 LKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVV 21673
Query: 2588 RWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASN 2646
W P S G I Y VE R++ Q W + TL D + L+ G Y+FR+ A N
Sbjct: 21674 CWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAEN 21733
Query: 2647 PWGISLPSEPSEFVR 2661
GIS PS S F +
Sbjct: 21734 AAGISAPSPTSPFYK 21748
Score = 60.8 bits (146), Expect = 2e-08
Identities = 53/183 (28%), Positives = 76/183 (41%), Gaps = 19/183 (10%)
Query: 2490 LQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG------------EITLKICN 2537
L+ K + T+TW P +LD + Y V +S + + K+
Sbjct: 21958 LKVKEVTKTSVTLTWDPP---LLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQ 22014
Query: 2538 LMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSS 2594
L S + +A N++G T+ +VK P P + + + SV L W P
Sbjct: 22015 LQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKPEH 22074
Query: 2595 TGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPS 2654
G I GY VE + +GS W + A+ T I L G Y FRVSA N GIS P
Sbjct: 22075 DGGSRILGYIVEMQTKGSDKW-ATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPR 22133
Query: 2655 EPS 2657
+ S
Sbjct: 22134 QLS 22136
Score = 60.1 bits (144), Expect = 3e-08
Identities = 47/176 (26%), Positives = 76/176 (43%), Gaps = 15/176 (8%)
Query: 2499 KPTITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
K T+ WK P Q+ + + S +TV + ++ K+ L+ + + +
Sbjct: 22653 KCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRIM 22712
Query: 2550 ATNDHGTTSTSATVKVQG-----VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
A N +G + V VP AP P + S+I+ W P+S G I GY
Sbjct: 22713 AVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYV 22772
Query: 2605 VEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF 2659
+E R++ W + + + L + L Y+FRVSA N G+S PS PS +
Sbjct: 22773 LEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAY 22828
Score = 60.1 bits (144), Expect = 3e-08
Identities = 44/150 (29%), Positives = 68/150 (45%), Gaps = 6/150 (4%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTST--SATVKVQ---GVP 2569
D ++ T+ + S T+KI L + A N +G ++ S V VQ P
Sbjct: 24446 DTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEP 24505
Query: 2570 AAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLV 2628
P P S ++++W P + G I GY +E +E+ S +W + + + DT
Sbjct: 24506 GPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFK 24565
Query: 2629 IEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
L G Y+F+VSA N GI PS+ SE
Sbjct: 24566 TTGLDEGLEYEFKVSAENIVGIGKPSKVSE 24595
Score = 59.7 bits (143), Expect = 4e-08
Identities = 42/145 (28%), Positives = 68/145 (46%), Gaps = 6/145 (4%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAA 2571
+ + Y + + + T +I NL S + +A+N++G T+ VKV P
Sbjct: 25239 ETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLP 25298
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P R + + + ++W P S G I+GY VE + +GS+ W + TL+ I
Sbjct: 25299 PGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEA--TIS 25356
Query: 2631 DLSPGCPYQFRVSASNPWGISLPSE 2655
L+ G Y FRV+A N G S P +
Sbjct: 25357 GLTAGEEYVFRVAAVNEKGRSDPRQ 25381
Score = 59.3 bits (142), Expect = 6e-08
Identities = 37/113 (32%), Positives = 51/113 (45%), Gaps = 5/113 (4%)
Query: 2558 STSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ 2617
ST ATV P P ++R+ S+ L W PP + G I GY VE GS W
Sbjct: 13582 STPATV-----PDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVA 13636
Query: 2618 SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAAD 2670
+T + + L G Y +RV A N G S PS P+E ++ + A +
Sbjct: 13637 CGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPE 13689
Score = 58.2 bits (139), Expect = 1e-07
Identities = 49/177 (27%), Positives = 65/177 (36%), Gaps = 22/177 (12%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTC------------ 2548
T+TW PD D + Y V D CN MP Y
Sbjct: 13900 TLTWCEPDD---DGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFR 13956
Query: 2549 -IATNDHGTTSTSATVKVQGV------PAAPNRPIAQERSCTSVILRWLPPSSTGNCTIS 2601
+A N G S + + + P P +P ++ TSV L W P G I
Sbjct: 13957 VLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIE 14016
Query: 2602 GYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
Y +E + G+ W + T ++ L G Y FRV A N G S PSEPS+
Sbjct: 14017 SYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSD 14073
Score = 58.2 bits (139), Expect = 1e-07
Identities = 33/92 (35%), Positives = 48/92 (52%), Gaps = 1/92 (1%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTY- 2626
VP AP P + SV L W P TG I+GY +E++E S +W+++ + +
Sbjct: 20175 VPDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRD 20234
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
+ L+ G Y+FRV A N G+ PS PSE
Sbjct: 20235 FKVTGLTEGLEYEFRVMAINLAGVGKPSLPSE 20266
Score = 58.2 bits (139), Expect = 1e-07
Identities = 42/173 (24%), Positives = 75/173 (43%), Gaps = 15/173 (8%)
Query: 2501 TITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIAT 2551
TI+W P+ + + + +S T+ + S ++KI L + A
Sbjct: 25505 TISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAE 25564
Query: 2552 NDHGTTSTSATVKVQGV-----PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVE 2606
N +G +S S + V P P P + +++++ W P + G + GY +E
Sbjct: 25565 NRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLE 25624
Query: 2607 YREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
Y+E S +W ++ + DT + + L G Y++RV A N GI S+ E
Sbjct: 25625 YKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCE 25677
Score = 57.8 bits (138), Expect = 2e-07
Identities = 35/107 (32%), Positives = 51/107 (47%), Gaps = 5/107 (4%)
Query: 2469 VAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDS 2528
V P F L + L G +V+++CKV G P +++W I T T ++C
Sbjct: 7680 VPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTC-- 7737
Query: 2529 GEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRP 2575
L + L DSG YTCIATN G+ SA + V+ P+ +P
Sbjct: 7738 ---ALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKP 7781
Score = 57.8 bits (138), Expect = 2e-07
Identities = 50/205 (24%), Positives = 83/205 (40%), Gaps = 37/205 (18%)
Query: 2490 LQCKVCGRPKP---------------TITWKGPDQN---------ILDTDNSSATYTVSS 2525
++ V GRP P T++W P + I + + T+ S
Sbjct: 16209 MRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVS 16268
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGT-----TSTSATVKVQGVPAAPNRPIAQER 2580
+ E T I L+ ++ +A N +G + + VP AP++P
Sbjct: 16269 SEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSV 16328
Query: 2581 SCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-----SVASTLDTYLVIEDLSPG 2635
+ S+ + W P G ++GY +E ++ S+ W++ A TL + L G
Sbjct: 16329 TRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEG 16388
Query: 2636 CPYQFRVSASNPWGI---SLPSEPS 2657
YQFRV A N G+ SLPS+P+
Sbjct: 16389 SDYQFRVYAINAAGVGPASLPSDPA 16413
Score = 57.8 bits (138), Expect = 2e-07
Identities = 51/178 (28%), Positives = 78/178 (43%), Gaps = 17/178 (9%)
Query: 2490 LQCKVCGRPKPTITWKGP---------DQNILDTDNSSATYTVSSCDSGEITLKICNLMP 2540
LQ K R T+ W P + I D + T++V S + K+ +L
Sbjct: 27372 LQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSE 27431
Query: 2541 QDSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQERSC-TSVILRWLPPSSTG 2596
+ + +A N+ G T+ VK VPA P R ++ + S TSVIL W P G
Sbjct: 27432 KTPFFFRVLAENEIGIGEPCETTEPVKAAEVPA-PIRDLSMKDSTKTSVILSWTKPDFDG 27490
Query: 2597 NCTISGYTVEYREEGSQIWQQS-VASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP 2653
I+ Y VE + +G Q W + ++ T + + + L +FRV A N G+S P
Sbjct: 27491 GSVITEYVVERKGKGEQTWSHAGISKTCE--IEVSQLKEQSVLEFRVFAKNEKGLSDP 27546
Score = 57.4 bits (137), Expect = 2e-07
Identities = 69/297 (23%), Positives = 112/297 (37%), Gaps = 36/297 (12%)
Query: 2390 AESSDGSIKKSCSWHTL-----RMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSS 2444
++SSD I K L MRK V+ T P + + + S +T+
Sbjct: 26169 SDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLR 26228
Query: 2445 EESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKP---- 2500
+ D D TS+ I N N + + ++ + + +V T+++ KV P P
Sbjct: 26229 TRAYVDTTDSRTSLTIENAN--RNDSGKYTLTIQNVLSAASLTLVV--KVLDTPGPPTNI 26284
Query: 2501 ----------TITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQ 2541
++W P+ + I + S + + + ++ K+ NL
Sbjct: 26285 TVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNLQEG 26344
Query: 2542 DSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNC 2598
+ N+ G T VK+ P+ P + S SV L WL P G
Sbjct: 26345 AIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGS 26404
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
I Y VE E+G + W + + T+ V+ L Y FRV A N G+S P E
Sbjct: 26405 RIVHYVVEALEKGQKNWVKCAVAK-STHHVVSGLRENSEYFFRVFAENQAGLSDPRE 26460
Score = 57.0 bits (136), Expect = 3e-07
Identities = 34/93 (36%), Positives = 47/93 (50%), Gaps = 3/93 (3%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ---SVASTLDT 2625
P+ P P A + +C SV L W PP G I GY VEY++ G + W++ + S +T
Sbjct: 17113 PSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPET 17172
Query: 2626 YLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
+ L G Y+FRV A N G S P+ E
Sbjct: 17173 KYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPE 17205
Score = 57.0 bits (136), Expect = 3e-07
Identities = 46/183 (25%), Positives = 78/183 (42%), Gaps = 23/183 (12%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVSSCDSG------------EITLKICNLMPQDSGIYTC 2548
+++W P + D ++ Y V CD + + ++ L+P I+
Sbjct: 19010 SLSWHIP---LEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRV 19066
Query: 2549 IATNDHGTTSTSATVKVQ-----GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
A N G + + K+ GVP+ P + + + + W P S G I GY
Sbjct: 19067 RAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGY 19126
Query: 2604 TVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV-- 2660
+E +E S +W ++ + + T L G Y FR+ A N G S PS+P+E+V
Sbjct: 19127 LIERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTA 19186
Query: 2661 RLP 2663
R+P
Sbjct: 19187 RMP 19189
Score = 56.6 bits (135), Expect = 4e-07
Identities = 42/142 (29%), Positives = 61/142 (42%), Gaps = 4/142 (2%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAA 2571
+++ Y S + + K+ NL + +A N+ G T VK P+
Sbjct: 24156 ESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSP 24215
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIED 2631
P + + S TS L W P G + GY VE + +G++ W VA + V+
Sbjct: 24216 PGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKW-SIVAESKVCNAVVTG 24274
Query: 2632 LSPGCPYQFRVSASNPWGISLP 2653
LS G YQFRV A N G S P
Sbjct: 24275 LSSGQEYQFRVKAYNEKGKSDP 24296
Score = 56.6 bits (135), Expect = 4e-07
Identities = 43/151 (28%), Positives = 60/151 (39%), Gaps = 7/151 (4%)
Query: 2535 ICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ------GVPAAPNRPIAQERSCTSVILR 2588
+ L+P + IA ND G + TS + P+ P S SV L+
Sbjct: 30391 VTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQ 30450
Query: 2589 WLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNP 2647
W P G I GY VEYR+ G W++S + D I L Y+FRV A N
Sbjct: 30451 WEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENE 30510
Query: 2648 WGISLPSEPSEFVRLPEYDAAADGATISWKE 2678
G+S P + ++ A G K+
Sbjct: 30511 TGLSRPRRTAMSIKTKLTSGEAPGIRKEMKD 30541
Score = 56.6 bits (135), Expect = 4e-07
Identities = 48/177 (27%), Positives = 71/177 (40%), Gaps = 23/177 (12%)
Query: 2502 ITWKGPDQNILDTDNSSATYTVSSCDSGE-------------ITLKICNLMPQDSGIYTC 2548
I+WK P D + Y V C++ E T +I NL +
Sbjct: 30742 ISWKPPAD---DGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRV 30798
Query: 2549 IATNDHGTTS---TSATVKVQGV---PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISG 2602
A N G + S+ V ++ P AP +P + S ++ W PP+S G I
Sbjct: 30799 SAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRN 30858
Query: 2603 YTVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
Y +E RE+ W + +T +++L G Y+FRV N G S SE SE
Sbjct: 30859 YYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISE 30915
Score = 56.2 bits (134), Expect = 5e-07
Identities = 50/186 (26%), Positives = 75/186 (40%), Gaps = 20/186 (10%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDS------------GEIT 2532
G V + K + +TW+ P I+D + Y V D+ + +
Sbjct: 19788 GPPVNVTVKEISKDSAYVTWEPP---IIDGGSPIINYVVQKRDAERKSWSTVTTECSKTS 19844
Query: 2533 LKICNLMPQDSGIYTCIATNDHGTTSTSAT---VKVQGVPAAPNRPIAQERSCTSVILRW 2589
++ NL S + A N++G T VK P + S +S + W
Sbjct: 19845 FRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGW 19904
Query: 2590 LPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG 2649
P S G I GY V++ E ++ WQ+ V +L +DL+ G Y FRVSA N G
Sbjct: 19905 KKPHSDGGSRIIGYVVDFLTEENK-WQR-VMKSLSLQYSAKDLTEGKEYTFRVSAENENG 19962
Query: 2650 ISLPSE 2655
PSE
Sbjct: 19963 EGTPSE 19968
Score = 55.8 bits (133), Expect = 6e-07
Identities = 46/175 (26%), Positives = 74/175 (42%), Gaps = 14/175 (8%)
Query: 2501 TITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIAT 2551
TI+W+ P + + D T+ V S S + LKI +L ++ A
Sbjct: 17622 TISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAE 17681
Query: 2552 NDHGT----TSTSATVKVQ-GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVE 2606
N G ST K + P+ P +P+ + + + + W P S G I+GY +E
Sbjct: 17682 NKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYME 17741
Query: 2607 YREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVR 2661
RE + + + D + L G Y+FRV A N G+S PS S+ ++
Sbjct: 17742 RREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIK 17796
Score = 55.5 bits (132), Expect = 8e-07
Identities = 53/246 (21%), Positives = 98/246 (39%), Gaps = 22/246 (8%)
Query: 2389 AAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESE 2448
+A + G++ SC + +++ + E E T E + + + V + +T+ +EE
Sbjct: 1016 SAVNEAGTVSTSC-YLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQA 1074
Query: 2449 CDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPD 2508
P + AP F+ V + G +V+ C+V G PKP + WK
Sbjct: 1075 -------------GPG--EPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSG 1119
Query: 2509 QNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG- 2567
+ +Y + +GE L I D+G YT + N HG TS SA++ +
Sbjct: 1120 VPLTTGYRYKVSY---NKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEAD 1176
Query: 2568 --VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDT 2625
+ + + + T+ + + S Y EY +E + I ++ T+
Sbjct: 1177 YELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVV 1236
Query: 2626 YLVIED 2631
+ED
Sbjct: 1237 RTYVED 1242
Score = 54.3 bits (129), Expect = 2e-06
Identities = 31/96 (32%), Positives = 46/96 (47%), Gaps = 5/96 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F+ L + +GD+V LQC+V G P+ T++W D + T +T +
Sbjct: 6079 PYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFT-----NNV 6133
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
TL + DSG YTC A N GT S+ ++Q
Sbjct: 6134 ATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQ 6169
Score = 53.9 bits (128), Expect = 2e-06
Identities = 55/256 (21%), Positives = 103/256 (40%), Gaps = 35/256 (13%)
Query: 2467 QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
+++AP F PL +V ++ T L CK+ G ++W + I +D +
Sbjct: 4109 RDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFV---- 4164
Query: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQE------- 2579
G +L+I + D+G +TC ATN G+ +S + VQ P+ +P +++
Sbjct: 4165 -EGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAV 4223
Query: 2580 ------RSCTSVILRWLPPS----STGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVI 2629
+ T + +RW + S G+C I T E E +++ + + +
Sbjct: 4224 CLKSTFQGSTPLTIRWFKGNKELVSGGSCYI---TKEALESSLELYLVKTSDSGTYTCKV 4280
Query: 2630 EDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAADGAT------ISWKENFDSA 2683
+++ G + P EPS+ ++ + A T I+W N
Sbjct: 4281 SNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFAN---- 4336
Query: 2684 YTELNEIGRGRFSIVK 2699
E+ E + R S V+
Sbjct: 4337 DREIKESSKHRMSFVE 4352
Score = 53.9 bits (128), Expect = 2e-06
Identities = 31/90 (34%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIW-QQSVASTLDTYL 2627
P+AP RP S ++ +RW P G I GY VE +E + +W +++ L+
Sbjct: 28841 PSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNY 28900
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSEPS 2657
+ L G YQFR A N G+S SE S
Sbjct: 28901 KVTGLVEGLEYQFRTYALNAAGVSKASEAS 28930
Score = 53.5 bits (127), Expect = 3e-06
Identities = 31/92 (33%), Positives = 50/92 (54%), Gaps = 7/92 (7%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-----SVASTL 2623
P P+ P ++++ +S+ L W PP+ G I GY VE +EEG+ W++ + +T
Sbjct: 15705 PGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTC 15764
Query: 2624 DTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
+ V+ +L Y+FRV A N G S PS+
Sbjct: 15765 E--CVVPNLKELRKYRFRVKAVNEAGESEPSD 15794
Score = 53.5 bits (127), Expect = 3e-06
Identities = 34/92 (36%), Positives = 42/92 (45%), Gaps = 1/92 (1%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTY 2626
VP P P + S+ + W P S G I GY VE +E +WQ S A
Sbjct: 21258 VPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNI 21317
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
L+ G Y+FRV A N G S PS+PSE
Sbjct: 21318 FKSSGLTDGIAYEFRVIAENMAGKSKPSKPSE 21349
Score = 53.5 bits (127), Expect = 3e-06
Identities = 42/152 (27%), Positives = 65/152 (42%), Gaps = 14/152 (9%)
Query: 2533 LKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG------VPAAPNRPIAQERSCTSVI 2586
LK+ +LM + A N G + S P P+ P + + S+
Sbjct: 29300 LKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSIS 29359
Query: 2587 LRWLPPSSTGNCTISGYTVEYREEGSQIWQQ--SVASTLDTYLVIEDLSPGCPYQFRVSA 2644
L W P G I GY +E +E+ + W + + A+ +T + DL G Y FRV+A
Sbjct: 29360 LAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAA 29419
Query: 2645 SNPWGISLPS------EPSEFVRLPEYDAAAD 2670
N G+S S EP E + +P+ + A D
Sbjct: 29420 VNVKGMSEYSESIAEIEPVERIEIPDLELADD 29451
Score = 53.1 bits (126), Expect = 4e-06
Identities = 31/96 (32%), Positives = 47/96 (48%), Gaps = 5/96 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P+ L L VT G + GRP+P I+W +Q + S+ D E
Sbjct: 3239 PQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLL-----STGFKCKFLHDGQE 3293
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
TL + P+D+ +YTC A ND+G +TSA++ V+
Sbjct: 3294 YTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVE 3329
Score = 53.1 bits (126), Expect = 4e-06
Identities = 33/108 (30%), Positives = 59/108 (54%), Gaps = 12/108 (11%)
Query: 2463 PNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYT 2522
P+F+++V P +L+ L G++ L CK+ G P +TW ++ + ++ N+ Y
Sbjct: 3737 PSFVKKVDPSYLM-------LPGESARLHCKLKGSPVIQVTWFKNNKELSES-NTVRMYF 3788
Query: 2523 VSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPA 2570
V+S E L I ++ +DSG Y+C A ND G+ S S + ++ P+
Sbjct: 3789 VNS----EAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPS 3832
Score = 53.1 bits (126), Expect = 4e-06
Identities = 30/71 (42%), Positives = 38/71 (53%), Gaps = 1/71 (1%)
Query: 2583 TSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRV 2642
T V L W P G I+GY VEY+EEG+Q W + T + V+ L G Y+FRV
Sbjct: 17424 TEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVT-NLECVVTGLQQGKTYRFRV 17482
Query: 2643 SASNPWGISLP 2653
A N G+ LP
Sbjct: 17483 KAENIVGLGLP 17493
Score = 52.8 bits (125), Expect = 5e-06
Identities = 33/94 (35%), Positives = 49/94 (52%), Gaps = 5/94 (5%)
Query: 2567 GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTY 2626
G P AP++PI ++ + S++++W P G+ I GY +E RE S W + S L+
Sbjct: 14901 GPPDAPDKPIVEDVTSNSMLVKWNEPKDNGS-PILGYWLEKREVNSTHWSRVNKSLLNAL 14959
Query: 2627 LV-IEDLSPGCPYQFRVSASN---PWGISLPSEP 2656
++ L G Y FRV A N P S PS+P
Sbjct: 14960 KANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDP 14993
Score = 52.8 bits (125), Expect = 5e-06
Identities = 48/187 (25%), Positives = 79/187 (42%), Gaps = 15/187 (8%)
Query: 2490 LQCKVCGRPKPTITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMP 2540
++ K K T+ W+ P + + + S +++ S E + ++
Sbjct: 26973 IEFKTVTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLEECIITTTKIIK 27032
Query: 2541 QDSGIYTCIATNDHGT----TSTSATVKVQGV-PAAPNRPIAQERSCTSVILRWLPPSST 2595
+ I+ A N +G S S K V P P P + + S+ + W P +
Sbjct: 27033 GNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIAD 27092
Query: 2596 GNCTISGYTVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPS 2654
G ISGY +E R++ S W + + T+ DT + L+ YQ+RV A N G S
Sbjct: 27093 GGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFS 27152
Query: 2655 EPSEFVR 2661
EPSEF +
Sbjct: 27153 EPSEFYK 27159
Score = 52.8 bits (125), Expect = 5e-06
Identities = 56/202 (27%), Positives = 79/202 (39%), Gaps = 33/202 (16%)
Query: 2468 EVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCD 2527
E PEF +PL + T +G+ V + P+P +TW Q I DN YT S D
Sbjct: 31687 ERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDK-KYTFES-D 31744
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPN---RPIAQ------ 2578
G L I ++ D YT +A N +G S A + V P + RP+ +
Sbjct: 31745 KGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANA 31804
Query: 2579 -----ERSCTSVILRWLPP-----SSTGNCTISGYTVEYREEGSQIWQQSVASTLDTY-L 2627
+ C + + +PP G G +E EG LD Y L
Sbjct: 31805 ECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEG-----------LDYYAL 31853
Query: 2628 VIEDLSPGCPYQFRVSASNPWG 2649
I D P +RV+A+N G
Sbjct: 31854 HIRDTLPEDTGYYRVTATNTAG 31875
Score = 52.4 bits (124), Expect = 7e-06
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 1/90 (1%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYL 2627
P P+ P + S + + W PP G +I+GY +E +E+ S W S + + +
Sbjct: 18396 PGRPDPPEVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPERRM 18455
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSEPS 2657
+++L P YQFRV A N GI PS PS
Sbjct: 18456 KVQNLLPDHEYQFRVKAENEIGIGEPSLPS 18485
Score = 51.6 bits (122), Expect = 1e-05
Identities = 45/172 (26%), Positives = 78/172 (45%), Gaps = 17/172 (9%)
Query: 2501 TITWKGPDQN---------ILDTDNSSATY-TVSSCDSGEITLKICNLMPQDSGIYTCIA 2550
++TW+ P+ + I D +S + T + + +++ + +++ + A
Sbjct: 13208 SLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRA 13267
Query: 2551 TNDHGTTSTSAT---VKVQGVPAAPNRPI---AQERSCTSVILRWLPPSSTGNCTISGYT 2604
N G SA VKV P+ P+ + +++ +SV L+W PP G I GY
Sbjct: 13268 QNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYI 13327
Query: 2605 VEYREEGSQIW-QQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
+E EEG W + ++ + + L G Y +RVSA N G+S PSE
Sbjct: 13328 IERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSE 13379
Score = 51.6 bits (122), Expect = 1e-05
Identities = 32/104 (30%), Positives = 48/104 (46%), Gaps = 3/104 (2%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL--DTY 2626
P P+ P + + S L W P G I+GY VE+++ G + W + T T
Sbjct: 20673 PGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQ 20732
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAAD 2670
V+ DL Y FR+SA N G+ P+ + V + E + A D
Sbjct: 20733 FVVPDLQTKEKYNFRISAINDAGVGEPAVIPD-VEIVEREMAPD 20775
Score = 51.6 bits (122), Expect = 1e-05
Identities = 30/91 (32%), Positives = 48/91 (52%), Gaps = 2/91 (2%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIW-QQSVASTLDTYLVIE 2630
P +P+ + +V L+W P TG I+ Y VE R+ + W + + ++ L+ +
Sbjct: 21360 PGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVS 21419
Query: 2631 DLSPGCPYQFRVSASNPWG-ISLPSEPSEFV 2660
L+ Y+FRV A N G IS PSEPS+ +
Sbjct: 21420 GLTEDAAYEFRVIAKNAAGAISPPSEPSDAI 21450
Score = 50.8 bits (120), Expect = 2e-05
Identities = 32/107 (29%), Positives = 49/107 (45%), Gaps = 5/107 (4%)
Query: 2469 VAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDS 2528
V P F L + +LG + IL+CKV G ++ W I+ T++ + C
Sbjct: 5798 VPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVC-- 5855
Query: 2529 GEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRP 2575
TL++ +L D G YTC+A N G+ A + VQ P+ P
Sbjct: 5856 ---TLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEP 5899
Score = 50.8 bits (120), Expect = 2e-05
Identities = 45/178 (25%), Positives = 77/178 (43%), Gaps = 15/178 (8%)
Query: 2499 KPTITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
K ++TW P Q+ + + S +TV + + +LK+ L+ + ++ +
Sbjct: 23735 KCSLTWSPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIM 23794
Query: 2550 ATNDHGTTST--SATVKVQGVPAAPNRPIAQERSCT---SVILRWLPPSSTGNCTISGYT 2604
A N +G SA V ++ P P + E + S+ + W P S G I GY
Sbjct: 23795 AVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYI 23854
Query: 2605 VEYREEGSQIW-QQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVR 2661
VE R+ W + + D L + L+ Y+FRVSA N G+ PS + + +
Sbjct: 23855 VEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYK 23912
Score = 50.4 bits (119), Expect = 3e-05
Identities = 56/219 (25%), Positives = 87/219 (39%), Gaps = 31/219 (14%)
Query: 2454 PNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILD 2513
P ++E+ F EV+ + PL D G + I+ V R TW +L
Sbjct: 13092 PVRNLEVTE-TFDGEVSLAWEEPLTD-----GGSKIIGYVVERRDIKRKTW------VLA 13139
Query: 2514 TDNS-SATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQG-- 2567
TD + S +TV+ G + ++ A N GT T V+ +
Sbjct: 13140 TDRAESCEFTVTGLQKGGVEY-----------LFRVSARNRVGTGEPVETDNPVEARSKY 13188
Query: 2568 -VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSV-ASTLDT 2625
VP P + + V L W PP G I+ Y +E R++ S W ++ D
Sbjct: 13189 DVPGPPLNVTITDVNRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDL 13248
Query: 2626 YLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
+ D+ G Y FRV A N G+ PS + FV++ +
Sbjct: 13249 SATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVAD 13287
Score = 50.4 bits (119), Expect = 3e-05
Identities = 47/168 (27%), Positives = 68/168 (40%), Gaps = 19/168 (11%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVSSCDSGEITL------------KICNLMPQDSGIYTC 2548
+ITW+ P +LD + Y V ++ + KI L S +
Sbjct: 23051 SITWEPP---LLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRV 23107
Query: 2549 IATNDHGT---TSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTV 2605
A N++G T+ +KV VP P + + + SV L W P G I Y V
Sbjct: 23108 TAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIV 23167
Query: 2606 EYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP 2653
E + + S+ W + A VI +L+ G Y FRV A N G S P
Sbjct: 23168 EMQAKHSEKWSE-CARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDP 23214
Score = 50.1 bits (118), Expect = 3e-05
Identities = 33/98 (33%), Positives = 45/98 (45%), Gaps = 4/98 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F++ V CL G T KV GRP P W Q I+ + T+ V + G
Sbjct: 1457 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIV----NDYTHKVVIKEDGT 1512
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGV 2568
+L I P DSG +T +A N G +S S + V+ V
Sbjct: 1513 QSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAV 1550
Score = 49.7 bits (117), Expect = 4e-05
Identities = 46/200 (23%), Positives = 79/200 (39%), Gaps = 10/200 (5%)
Query: 2469 VAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDS 2528
+ P F L + + G + L+C V G +I W DQ I ++S Y S D+
Sbjct: 4673 IPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEI----SASEKYKFSFHDN 4728
Query: 2529 GEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILR 2588
L+I L DSG YTC ATN G S + V+ P +P +Q+ + + +
Sbjct: 4729 TAF-LEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQL 4787
Query: 2589 WLPPSSTGNCTISGYTVE---YREEGSQIWQQSVASTLDTYL--VIEDLSPGCPYQFRVS 2643
T TI + + +W+ +++L+ + + + C V
Sbjct: 4788 KALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVG 4847
Query: 2644 ASNPWGISLPSEPSEFVRLP 2663
+ EP +F++ P
Sbjct: 4848 TATSKATLFVKEPPQFIKKP 4867
Score = 49.7 bits (117), Expect = 4e-05
Identities = 43/140 (30%), Positives = 66/140 (47%), Gaps = 21/140 (15%)
Query: 2463 PNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYT 2522
P FI+E+ P +V DV L+C+V G P +TW ++ I SS YT
Sbjct: 4955 PTFIRELKPVEVVKYSDVE--------LECEVTGTPPFEVTWLKNNREI----RSSKKYT 5002
Query: 2523 VSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSC 2582
++ S L I P D+G Y CI +N+ G+ S S V ++ P+ I + +
Sbjct: 5003 LTDRVS-VFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSF----IKKIENT 5057
Query: 2583 TSVILRWLPPSSTGNCTISG 2602
T+V L S+T T++G
Sbjct: 5058 TTV----LKSSATFQSTVAG 5073
Score = 49.7 bits (117), Expect = 4e-05
Identities = 34/113 (30%), Positives = 58/113 (51%), Gaps = 12/113 (10%)
Query: 2463 PNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYT 2522
P FI+++ P +V + T +CK+ G P+ + W + I + S+ +
Sbjct: 7305 PRFIKKLEPSRIVKQDEFTRY-------ECKIGGSPEIKVLWYKDETEIQE----SSKFR 7353
Query: 2523 VSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRP 2575
+S DS + L++ NL +DSG YTC A N G+ S+S ++KV+ P +P
Sbjct: 7354 MSFVDSVAV-LEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPIFRKKP 7405
Score = 49.7 bits (117), Expect = 4e-05
Identities = 33/88 (37%), Positives = 45/88 (51%), Gaps = 3/88 (3%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P RP A + SV L+W P+ G I+GY VE +E W + S + +DT+ +
Sbjct: 22442 PGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVT 22501
Query: 2631 DLSPGCPYQFRVSASNPWGISLPSEPSE 2658
L Y+FRV A N G+ SEPSE
Sbjct: 22502 GLVEDHRYEFRVIARNAAGVF--SEPSE 22527
Score = 49.7 bits (117), Expect = 4e-05
Identities = 51/196 (26%), Positives = 81/196 (41%), Gaps = 21/196 (10%)
Query: 2477 LVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG-----EI 2531
LV V G ++ K R TITW+ P +D Y V ++ +
Sbjct: 29531 LVKVYDTPGPCPSVKVKEVSRDSVTITWEIPT---IDGGAPVNNYIVEKREAAMRAFKTV 29587
Query: 2532 TLKICNLMPQDSGI-------YTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQERS 2581
T K + + SG+ + + N +G TS V V VP P + + +
Sbjct: 29588 TTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVT 29647
Query: 2582 CTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYL--VIEDLSPGCPYQ 2639
++V L W P G ++GY +E + G++ W + V + T L + L+ G Y
Sbjct: 29648 KSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMK-VVTLKPTVLEHTVTSLNEGEQYL 29706
Query: 2640 FRVSASNPWGISLPSE 2655
FR+ A N G+S P E
Sbjct: 29707 FRIRAQNEKGVSEPRE 29722
Score = 49.7 bits (117), Expect = 4e-05
Identities = 46/177 (25%), Positives = 70/177 (39%), Gaps = 23/177 (12%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVSSCDSGE------------ITLKICNLMPQDSGIYTC 2548
TI+W+ P+ LD + Y V D+ T K L + ++
Sbjct: 29850 TISWEPPE---LDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRV 29906
Query: 2549 IATNDHGTTSTSATVKVQ-----GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
ATN G S + ++ +P P + S + L W PP G ++GY
Sbjct: 29907 AATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGY 29966
Query: 2604 TVEYREEGSQIWQQ--SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
VE +E + W + V T+ Y L+ G Y+ RV+A N G PS PS+
Sbjct: 29967 IVERKEVRADRWVRVNKVPVTMTRYR-STGLTEGLEYEHRVTAINARGSGKPSRPSK 30022
Score = 49.3 bits (116), Expect = 6e-05
Identities = 48/203 (23%), Positives = 78/203 (38%), Gaps = 14/203 (6%)
Query: 2472 EFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQN--------ILDTDNSSATYTV 2523
+F V+V + G + L+ V R + W P+ + I++ ++
Sbjct: 15185 KFAAARVEVFDVPGPVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWR 15244
Query: 2524 SSCDSGEITLKICNLMPQDSGIYTCIATNDHGT-----TSTSATVKVQGVPAAPNRPIAQ 2578
++ I L+ + IA N G V G P +P R
Sbjct: 15245 QPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYT 15304
Query: 2579 ERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGCP 2637
ER+ +++ L W P S G I GY +E R +++ + T ++E+L
Sbjct: 15305 ERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQM 15364
Query: 2638 YQFRVSASNPWGISLPSEPSEFV 2660
Y+FRV A N G S PS P V
Sbjct: 15365 YEFRVKAVNEIGESEPSLPLNVV 15387
Score = 49.3 bits (116), Expect = 6e-05
Identities = 71/323 (21%), Positives = 121/323 (37%), Gaps = 34/323 (10%)
Query: 2398 KKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTS 2457
KK W ++ + E + KN G L + VK N ESE ++ S
Sbjct: 30866 KKQNKWISVTTEEIRETVFSVKNLIEG-------LEYEFRVKCENLGGESEWSEI----S 30914
Query: 2458 MEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNS 2517
I + + AP F L ++ L CKV G PKP + W + I+
Sbjct: 30915 EPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEII---AD 30971
Query: 2518 SATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA 2577
Y + G L I ++ D+ +Y ATN G+ S +A+++V+ VPA + P
Sbjct: 30972 GLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVE-VPAKIHLPKT 31030
Query: 2578 QERSCTSVILRW------LPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIED 2631
E LR +P S + I+ + + + +Q V + + +
Sbjct: 31031 LEGMGAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNG 31090
Query: 2632 LSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE-------YDAAADGATISWKENFDSAY 2684
+ + V A N +GI + + +P+ D + D ++W E
Sbjct: 31091 VERKDAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGG 31150
Query: 2685 TELNEIGRGRFSIVKKCIHKATR 2707
+++ IV+KC A R
Sbjct: 31151 SKITNY------IVEKCATTAER 31167
Score = 48.5 bits (114), Expect = 1e-04
Identities = 49/163 (30%), Positives = 73/163 (44%), Gaps = 20/163 (12%)
Query: 2418 GKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPL 2477
G+ + T P K G + S+K TN S ++ + E PNF+Q L
Sbjct: 61 GRAKLTIPAVTKANSG-RYSLKATNGSGQAT-STAELLVKAETAPPNFVQR--------L 110
Query: 2478 VDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEI-TLKIC 2536
+T G V LQ +V G P P + + I SS + +S G++ +L I
Sbjct: 111 QSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEI----QSSLDFQISQ--EGDLYSLLIA 164
Query: 2537 NLMPQDSGIYTCIATNDHGTTSTSATVKVQG---VPAAPNRPI 2576
P+DSG Y+ ATN G +++A + VQG VPA + I
Sbjct: 165 EAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTI 207
Score = 48.5 bits (114), Expect = 1e-04
Identities = 32/100 (32%), Positives = 47/100 (47%), Gaps = 5/100 (5%)
Query: 2470 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG 2529
+P F + V + + G++ +C V G ITW ++ I N YT++ C
Sbjct: 6270 SPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGN----YTIT-CVGN 6324
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVP 2569
L+I + DSG YTC ATND G SA + V+ P
Sbjct: 6325 TPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPP 6364
Score = 48.5 bits (114), Expect = 1e-04
Identities = 33/99 (33%), Positives = 49/99 (49%), Gaps = 3/99 (3%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P +P + SV L W P G ++GY VE R+ S+ W + + + + +
Sbjct: 20277 PGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVT 20336
Query: 2631 DLSPGCPYQFRVSASNPWG-ISLPSEPSE-FVRLPEYDA 2667
DL G Y+FR+ A N G IS PSE +E + EY+A
Sbjct: 20337 DLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEA 20375
Score = 48.5 bits (114), Expect = 1e-04
Identities = 30/95 (31%), Positives = 44/95 (46%), Gaps = 2/95 (2%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQ--QSVASTLDTY 2626
P P + + + +S+ L W P G ++GY VE R+ + W + T
Sbjct: 27167 PGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTE 27226
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVR 2661
V+ +L PG Y FRVSA N G P E +E V+
Sbjct: 27227 YVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQ 27261
Score = 48.1 bits (113), Expect = 1e-04
Identities = 36/127 (28%), Positives = 46/127 (36%), Gaps = 1/127 (0%)
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRW 2589
+ + +I D G Y + N HG +KV VP E V L W
Sbjct: 13051 QTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLAW 13110
Query: 2590 LPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSP-GCPYQFRVSASNPW 2648
P + G I GY VE R+ + W + + L G Y FRVSA N
Sbjct: 13111 EEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSARNRV 13170
Query: 2649 GISLPSE 2655
G P E
Sbjct: 13171 GTGEPVE 13177
Score = 47.8 bits (112), Expect = 2e-04
Identities = 34/104 (32%), Positives = 47/104 (45%), Gaps = 15/104 (14%)
Query: 2567 GVPAAPNRPIAQERSC-------------TSVILRWLPPSSTGNCTISGYTVEYREEGSQ 2613
G P+ P+ P+ +C SV L W P+ G I+GY VE R+
Sbjct: 26753 GKPSHPSEPVLAIDACEPPRNVRITDISKNSVSLSWQQPAFDGGSKITGYIVERRDLPDG 26812
Query: 2614 IW-QQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG-ISLPSE 2655
W + S + +T +I L+ Y+FRV A N G IS PSE
Sbjct: 26813 RWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSE 26856
Score = 47.8 bits (112), Expect = 2e-04
Identities = 30/99 (30%), Positives = 44/99 (44%), Gaps = 2/99 (2%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVAS--TLDT 2625
VP AP P + S+ L W P S G I Y +E RE+ S W + ++ +T
Sbjct: 28151 VPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISET 28210
Query: 2626 YLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
+ L+ G Y+F V A N G+ S S ++ E
Sbjct: 28211 RFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCRE 28249
Score = 47.8 bits (112), Expect = 2e-04
Identities = 29/105 (27%), Positives = 45/105 (42%), Gaps = 7/105 (6%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYL 2627
P P P + + TSV L W P G ++GY +E ++ W + + T
Sbjct: 30033 PGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREY 30092
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSE------PSEFVRLPEYD 2666
+ L G Y+FRV A N G P+E +E + P+Y+
Sbjct: 30093 TLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYE 30137
Score = 47.4 bits (111), Expect = 2e-04
Identities = 30/90 (33%), Positives = 42/90 (46%), Gaps = 6/90 (6%)
Query: 2483 LLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQD 2542
L G V CK+ G P P I W + I + Y + G +L+I ++P+D
Sbjct: 1303 LEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGER----YQMDFLQDGRASLRIPVVLPED 1358
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAP 2572
GIYT A+N G S + V+ PAAP
Sbjct: 1359 EGIYTAFASNIKGNAICSGKLYVE--PAAP 1386
Score = 47.4 bits (111), Expect = 2e-04
Identities = 34/101 (33%), Positives = 50/101 (49%), Gaps = 7/101 (6%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F+ L V + V L+C+V K T+TW Q + Y + C +
Sbjct: 3644 PHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKL----PPGKDYKI--CFEDK 3697
Query: 2531 I-TLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPA 2570
I TL+I +DSG Y C A+N+ G++S SATV V+ P+
Sbjct: 3698 IATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPS 3738
Score = 47.4 bits (111), Expect = 2e-04
Identities = 27/87 (31%), Positives = 40/87 (45%), Gaps = 1/87 (1%)
Query: 2573 NRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIW-QQSVASTLDTYLVIED 2631
N P + + +SV L W P G ++GY +E +E + W + + T +
Sbjct: 30334 NPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTG 30393
Query: 2632 LSPGCPYQFRVSASNPWGISLPSEPSE 2658
L P YQFR+ A N G+S S SE
Sbjct: 30394 LVPDAEYQFRIIAQNDVGLSETSPASE 30420
Score = 47.0 bits (110), Expect = 3e-04
Identities = 63/271 (23%), Positives = 114/271 (42%), Gaps = 26/271 (9%)
Query: 2302 YHQPGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLV 2361
+ + G + AS + + GT+S+ +I+ N C + V + + +V
Sbjct: 4146 WFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVG---SKDSSGALIV 4202
Query: 2362 YQPASDHS-PAAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKN 2420
+P S + P ++ +PGS A K+T GS + W + E+ + G
Sbjct: 4203 QEPPSFVTKPGSKDVLPGS--AVCLKSTF----QGSTPLTIRW----FKGNKELVSGGSC 4252
Query: 2421 EATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDV 2480
T + ++ + +T+ S C + +E F++E P V ++
Sbjct: 4253 YITKEALESSL---ELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKE--PATFVEKLEP 4307
Query: 2481 TCLL--GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNL 2538
+ LL GD L CKV G P ITW D+ I ++ ++ S+ L++ ++
Sbjct: 4308 SQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTA-----VLRLTDV 4362
Query: 2539 MPQDSGIYTCIATNDHGTTSTSATVKVQGVP 2569
+DSG Y C A N+ G+ S+ V V+ P
Sbjct: 4363 GIEDSGEYMCEAQNEAGSDHCSSIVIVKESP 4393
Score = 47.0 bits (110), Expect = 3e-04
Identities = 36/117 (30%), Positives = 52/117 (44%), Gaps = 10/117 (8%)
Query: 2468 EVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCD 2527
EV P F + V V LG++ +C V G ITW ++ I N T ++
Sbjct: 7209 EVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTA- 7267
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVP-----AAPNRPIAQE 2579
TL + + D+G YTC A+N G S SA + VQ P P+R + Q+
Sbjct: 7268 ----TLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQD 7320
Score = 46.6 bits (109), Expect = 4e-04
Identities = 35/131 (26%), Positives = 61/131 (46%), Gaps = 10/131 (7%)
Query: 2467 QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
Q + P F L + +LG ++ ++CKV G + W + I ++SA Y + C
Sbjct: 5233 QNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEI----STSAKYRL-VC 5287
Query: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTS-- 2584
++L++ NL +D+ YTC +N G + S + V+ P+ +P Q+ S
Sbjct: 5288 HERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPDSTV 5347
Query: 2585 ---VILRWLPP 2592
IL+ PP
Sbjct: 5348 EFKAILKGTPP 5358
Score = 46.6 bits (109), Expect = 4e-04
Identities = 80/342 (23%), Positives = 124/342 (36%), Gaps = 60/342 (17%)
Query: 2349 QVLAVNQQNMCLVYQP-----ASDHSPAAEGWVPGSILAPLT-----KATAAESSDGSIK 2398
+V A+N+Q +P A D A E ++ +LA LT K + G +
Sbjct: 13660 RVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPE 13719
Query: 2399 KSCSWHT----LRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEE-SECDDLD 2453
+W L+ KR +EN K I+ +K S T E + C
Sbjct: 13720 PKITWTKADMILKQDKRITIENVPKKSTV------TIVDSKRSDTGTYIIEAVNVC---- 13769
Query: 2454 PNTSMEILNPNFIQEVAPEFLVPLVDVT---CLL--------GDTVILQCKVCGRPKPTI 2502
+ ++ N + + P + DVT CLL G + I V R +
Sbjct: 13770 -GRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSE 13828
Query: 2503 TWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT----TS 2558
W + DT+ K L+P I+ A N +G +
Sbjct: 13829 VWHKLSSTVKDTN-----------------FKATKLIPNKEYIFRVAAENMYGVGEPVQA 13871
Query: 2559 TSATVKVQ-GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ 2617
+ T K Q P P R + + +V L W P G I+GY VE + + W +
Sbjct: 13872 SPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVR 13931
Query: 2618 -SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
+ DT ++ L+ Y+FRV A N G PS+ +E
Sbjct: 13932 CNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTE 13973
Score = 46.6 bits (109), Expect = 4e-04
Identities = 26/88 (29%), Positives = 40/88 (45%), Gaps = 1/88 (1%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDT-YL 2627
P P P + S T++ L W PP+ G I GY V+ + G+ W + +
Sbjct: 15002 PPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQY 15061
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSE 2655
++++ G Y+ RVSA N G P E
Sbjct: 15062 TVKEIREGADYKLRVSAVNAAGEGPPGE 15089
Score = 46.6 bits (109), Expect = 4e-04
Identities = 36/130 (27%), Positives = 50/130 (38%), Gaps = 8/130 (6%)
Query: 2529 GEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGV------PAAPNRPIAQERSC 2582
GE+ L++ L+ + A N G + S Q P PN P + +
Sbjct: 22792 GELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITR 22851
Query: 2583 TSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVAST--LDTYLVIEDLSPGCPYQF 2640
+SV L W P G C I GY VE + W T T + +E L Y F
Sbjct: 22852 SSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNF 22911
Query: 2641 RVSASNPWGI 2650
R+ A N G+
Sbjct: 22912 RICAINKAGV 22921
Score = 46.6 bits (109), Expect = 4e-04
Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 3/91 (3%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P P + + ++ L+W PP G I GY++E R+ G++ W + + + +
Sbjct: 27858 PGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQ-GNERWVRCNFTDVSECQYTVT 27916
Query: 2631 DLSPGCPYQFRVSASNPWG-ISLPSEPSEFV 2660
LSPG Y+FR+ A N G IS PS+ S +
Sbjct: 27917 GLSPGDRYEFRIIARNAVGTISPPSQSSGII 27947
Score = 46.2 bits (108), Expect = 5e-04
Identities = 32/104 (30%), Positives = 45/104 (43%), Gaps = 3/104 (2%)
Query: 2470 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG 2529
AP F PL V L G T + + G P P ++W Q I S+ S G
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVI---STSTLPGVQISFSDG 61
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPN 2573
L I + +SG Y+ ATN G +++A + V+ A PN
Sbjct: 62 RAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPN 105
Score = 46.2 bits (108), Expect = 5e-04
Identities = 33/107 (30%), Positives = 51/107 (47%), Gaps = 13/107 (12%)
Query: 2463 PNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYT 2522
P F Q+ +P V L G VILQC++ G P + W + + +S +
Sbjct: 6458 PVFTQKPSP--------VGALKGSDVILQCEISGTPPFEVVWVKDRKQV----RNSKKFK 6505
Query: 2523 VSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVP 2569
++S + +L I NL D G Y C ATN+ G+ + S +VK + P
Sbjct: 6506 ITS-KHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPP 6551
Score = 46.2 bits (108), Expect = 5e-04
Identities = 30/110 (27%), Positives = 42/110 (38%), Gaps = 8/110 (7%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVAST--LDTY 2626
P P+ P + S +SV L W P G + GY VE +E + W T
Sbjct: 25003 PGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQ 25062
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSE------PSEFVRLPEYDAAAD 2670
+ L Y FR+ A N G+ P+ E + PE + AD
Sbjct: 25063 FTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDAD 25112
Score = 45.8 bits (107), Expect = 6e-04
Identities = 28/91 (30%), Positives = 47/91 (51%), Gaps = 5/91 (5%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
GD+ L+CK+ G P+ + W + + +D Y ++ DS + +++ NL +DSG
Sbjct: 5438 GDSSRLECKIAGSPEIRVVWFRNEHELPASDK----YRMTFIDSVAV-IQMNNLSTEDSG 5492
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRP 2575
+ C A N G+TS S V V+ P + P
Sbjct: 5493 DFICEAQNPAGSTSCSTKVIVKEPPVFSSFP 5523
Score = 45.4 bits (106), Expect = 8e-04
Identities = 25/81 (30%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 2585 VILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVAST-LDTYLVIEDLSPGCPYQFRVS 2643
V L+W PP + G I Y +E +E W ++ + D + D+ G QF+V
Sbjct: 14200 VDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVR 14259
Query: 2644 ASNPWGISLPSEPSEFVRLPE 2664
A N G+ PSEP+E + + +
Sbjct: 14260 AENEAGVGHPSEPTEILSIED 14280
Score = 45.4 bits (106), Expect = 8e-04
Identities = 54/224 (24%), Positives = 80/224 (35%), Gaps = 60/224 (26%)
Query: 2496 GRPKP-----------TITWKGPDQN--------ILDTDNSSATYTVSSCDSG--EITLK 2534
GRP P T+ W P+ + L+ +T V S E +K
Sbjct: 18397 GRPDPPEVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPERRMK 18456
Query: 2535 ICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQ---------------- 2578
+ NL+P + A N+ G G P+ P+RP+
Sbjct: 18457 VQNLLPDHEYQFRVKAENEIGI----------GEPSLPSRPVVAKDPIEPPGPPTNFRVV 18506
Query: 2579 ERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQI-----WQQ--SVASTLDTYLVIED 2631
+ + S+ L W P G I GY VE R + + W++ + A + +
Sbjct: 18507 DTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTS 18566
Query: 2632 LSPGCPYQFRVSASNPWGISLPSE------PSEFVRLPEYDAAA 2669
L Y+FRV A N GI P+E P E + PE D A
Sbjct: 18567 LDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDA 18610
Score = 45.4 bits (106), Expect = 8e-04
Identities = 46/155 (29%), Positives = 60/155 (38%), Gaps = 14/155 (9%)
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV------QGVPAAPNRPIAQERSCT 2583
E TLK L + A N G S K Q P P P + + +
Sbjct: 19544 ERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRS 19603
Query: 2584 SVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLD-TYLVIEDLSPGCPYQFR 2641
SV L W P+ G I GY VE + S W + ++ L T + L YQFR
Sbjct: 19604 SVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFR 19663
Query: 2642 VSASNPWGISLPSE------PSEFVRLPEYDAAAD 2670
V A N G S PS+ P + + PE + AD
Sbjct: 19664 VYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDAD 19698
Score = 45.4 bits (106), Expect = 8e-04
Identities = 51/277 (18%), Positives = 107/277 (38%), Gaps = 25/277 (9%)
Query: 2304 QPGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQ 2363
+P + E K N + S++ ++ Y+L+ VS + A N + C
Sbjct: 33160 EPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQC---- 33215
Query: 2364 PASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEAT 2423
S A V + P + S D S++ S S +++M + + ++
Sbjct: 33216 -----SATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSS 33270
Query: 2424 GPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQE------------VAP 2471
++ +S + +S +ES + + ++ M I N ++ + P
Sbjct: 33271 SASSMTEMKFASMSAQSMSSMQESFVE-MSSSSFMGISNMTQLESSTSKMLKAGIRGIPP 33329
Query: 2472 EFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEI 2531
+ D++ G + + C G P P +TW + I + + + + D
Sbjct: 33330 KIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGR--FHIENTDD-LT 33386
Query: 2532 TLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGV 2568
TL I ++ QD G+YT N+ G+ S + + ++ +
Sbjct: 33387 TLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIRSI 33423
Score = 45.1 bits (105), Expect = 0.001
Identities = 45/147 (30%), Positives = 66/147 (44%), Gaps = 16/147 (10%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F+ + + T +L + Q V G P +ITW DQ ILD D++ +S DS
Sbjct: 5048 PSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQ-ILDEDDN---VYISFVDS-V 5102
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWL 2590
TL+I ++ SG YTC A N+ G A + VQ P SV +
Sbjct: 5103 ATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQ-------EPAQIVEKAKSVDVTEK 5155
Query: 2591 PPSSTGNCTISG---YTVEYREEGSQI 2614
P T C ++G V++ ++G QI
Sbjct: 5156 DP-MTLECVVAGTPELKVKWLKDGKQI 5181
Score = 45.1 bits (105), Expect = 0.001
Identities = 61/237 (25%), Positives = 100/237 (42%), Gaps = 38/237 (16%)
Query: 2457 SMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDN 2516
++ +L P I E PE + GDT L+C V G P+ + W D L +DN
Sbjct: 7579 TLSVLEPATIVE-KPE------SIKVTTGDTCTLECTVAGTPELSTKWF-KDGKELTSDN 7630
Query: 2517 SSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV--QGVPAAPNR 2574
Y +S + LKI N+ P DSG+Y+ N G S +A+++V + VP + R
Sbjct: 7631 K---YKISFFNKVS-GLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTR 7686
Query: 2575 PIAQER--SCTSVILRWLPPSSTGNCTISG---YTVEYREEGSQIWQ----QSVASTLDT 2625
+ + S +SV++ C + G +V + EG++I Q+ +
Sbjct: 7687 KLKETNGLSGSSVVM---------ECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTC 7737
Query: 2626 YLVIEDLSPGCPYQFRVSASNPWG---ISLP---SEPSEFVRLPEYDAAADGATISW 2676
L + L + A+N G S P EP FV+ P+ G +++
Sbjct: 7738 ALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTF 7794
Score = 45.1 bits (105), Expect = 0.001
Identities = 30/88 (34%), Positives = 42/88 (47%), Gaps = 3/88 (3%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P +P + SV L+W P G I+GY VE RE W + + + +TY +
Sbjct: 25688 PGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVT 25747
Query: 2631 DLSPGCPYQFRVSASNPWGISLPSEPSE 2658
+L+ Y+FRV A N SEPSE
Sbjct: 25748 ELTEDQRYEFRVFARN--AADSVSEPSE 25773
Score = 44.7 bits (104), Expect = 0.001
Identities = 31/100 (31%), Positives = 46/100 (46%), Gaps = 5/100 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F L VT G+ V L C V G I W + I +D S ++ SG
Sbjct: 8346 PVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFA-----SGT 8400
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPA 2570
L++ ++ DSG Y C A+N G+ +T + V ++ PA
Sbjct: 8401 AVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPA 8440
Score = 44.7 bits (104), Expect = 0.001
Identities = 43/174 (24%), Positives = 71/174 (40%), Gaps = 21/174 (12%)
Query: 2502 ITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATN 2552
++WK PD + I +T + D G T + +L+ + + A N
Sbjct: 15930 LSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAEN 15989
Query: 2553 DHGTTSTSATVK---VQGVPAAPNRPIAQERSC---TSVILRWLPPSSTGNCTISGYTVE 2606
G T++ + P+ PI + +V L W PP + G ++ Y VE
Sbjct: 15990 RFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVE 16049
Query: 2607 ---YREEGS--QIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPS 2654
+ G+ + W+Q + + +EDL G Y+FRV A N G+S PS
Sbjct: 16050 CLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPS 16103
Score = 44.3 bits (103), Expect = 0.002
Identities = 34/108 (31%), Positives = 53/108 (49%), Gaps = 11/108 (10%)
Query: 2465 FIQEVAPEFLVPLVDVTCLL-GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSAT--Y 2521
F++E P+F+ V L G + +C++ G PK ++W LD + +A +
Sbjct: 4856 FVKE-PPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSW------YLDGNEITAIQKH 4908
Query: 2522 TVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVP 2569
+S D G T +I ++SG Y C A ND GT S S +KV+ P
Sbjct: 4909 GISFID-GLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPP 4955
Score = 44.3 bits (103), Expect = 0.002
Identities = 49/215 (22%), Positives = 92/215 (42%), Gaps = 29/215 (13%)
Query: 2478 VDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICN 2537
VDVT D + L+C V G P+ + W + I+ + Y S ++ + +I +
Sbjct: 5150 VDVT--EKDPMTLECVVAGTPELKVKWLKDGKQIVPS-----RYFSMSFENNVASFRIQS 5202
Query: 2538 LMPQDSGIYTCIATNDHGTTSTSATVKV--QGVPAAPNRPIAQERSCTSVILRWLPPSST 2595
+M QDSG YT ND G++S A ++V Q +P + + + + + + L S
Sbjct: 5203 VMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTK-------MDKVLGSSIH 5255
Query: 2596 GNCTISG---YTVEYREEGSQI----------WQQSVASTLDTYLVIEDLSPGCPYQFRV 2642
C +SG + ++ ++G +I ++SV+ ++ + + + C
Sbjct: 5256 MECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVA 5315
Query: 2643 SASNPWGISLPSEPSEFVRLPEYDAAADGATISWK 2677
GI EP F+ P A +T+ +K
Sbjct: 5316 GDDACSGILTVKEPPSFLVKPGRQQAIPDSTVEFK 5350
Score = 44.3 bits (103), Expect = 0.002
Identities = 49/191 (25%), Positives = 79/191 (41%), Gaps = 28/191 (14%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G+++ L+CK+ G P+ ++W D + + S Y +S +S + L I +DSG
Sbjct: 6379 GESIQLECKISGSPEIKVSWFRNDSEL----HESWKYNMSFINSVAL-LTINEASAEDSG 6433
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPI-AQERSCTSVILRWLPPSSTGNCTISG- 2602
Y C A N G S S + V+ P +P + VIL+ C ISG
Sbjct: 6434 DYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQ---------CEISGT 6484
Query: 2603 --YTVEYREEGSQIWQQS----VASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPS-- 2654
+ V + ++ Q+ + DT L I +L ++ A+N G S
Sbjct: 6485 PPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCS 6544
Query: 2655 ----EPSEFVR 2661
EP FV+
Sbjct: 6545 VKFKEPPRFVK 6555
Score = 44.3 bits (103), Expect = 0.002
Identities = 48/199 (24%), Positives = 76/199 (38%), Gaps = 32/199 (16%)
Query: 2487 TVILQCKVCGRPKPT--------------ITWKGPDQN--------ILDTDNSSA-TYTV 2523
T + KV G P P +TW+ P+ + +L+ + TY
Sbjct: 14469 TASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIP 14528
Query: 2524 SSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQE- 2579
+++ + +L+P + A N G V Q P+ P+ E
Sbjct: 14529 VMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEV 14588
Query: 2580 --RSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLD--TYLVIEDLSPG 2635
+ ++ + W PP G I GY +E +G + W++ + TY + L G
Sbjct: 14589 HNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTY-TAKGLEEG 14647
Query: 2636 CPYQFRVSASNPWGISLPS 2654
YQFRV A N GIS PS
Sbjct: 14648 KEYQFRVRAENAAGISEPS 14666
Score = 44.3 bits (103), Expect = 0.002
Identities = 30/88 (34%), Positives = 43/88 (48%), Gaps = 2/88 (2%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P RP A + +V L+W P+ G I+GY VE ++ W + S + L+T +
Sbjct: 24606 PGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVS 24665
Query: 2631 DLSPGCPYQFRVSASNPWG-ISLPSEPS 2657
L Y+FRV A N G S PS+ S
Sbjct: 24666 GLVEDQRYEFRVIARNAAGNFSEPSDSS 24693
Score = 44.3 bits (103), Expect = 0.002
Identities = 30/109 (27%), Positives = 46/109 (42%), Gaps = 4/109 (3%)
Query: 2546 YTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTV 2605
Y A + S + Q AP RP + + ++V L W P+ G + GY +
Sbjct: 28916 YALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGYII 28975
Query: 2606 EYR---EEGSQIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI 2650
E + E G W + + D + + LS G Y+FRV A N G+
Sbjct: 28976 ERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGV 29024
Score = 43.9 bits (102), Expect = 0.002
Identities = 34/119 (28%), Positives = 50/119 (42%), Gaps = 8/119 (6%)
Query: 2550 ATNDHGTTSTSATVKVQGV--PAAPNRPIAQ----ERSCTSVILRWLPPSSTGNCTISGY 2603
A N+ G S ++ + P +P P + + + W PP G I GY
Sbjct: 14260 AENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGY 14319
Query: 2604 TVEYREEGSQIWQQSVASTLD--TYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
VE G++ W + + + + V E + P Y RV A N G+S PSE SE V
Sbjct: 14320 HVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENV 14378
Score = 43.9 bits (102), Expect = 0.002
Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 4/96 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F L + C G +V + +V G P PT+ W+ Q + N +
Sbjct: 31795 PMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHE----GLDY 31850
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
L I + +P+D+G Y ATN G+TS A ++V+
Sbjct: 31851 YALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVE 31886
Score = 43.5 bits (101), Expect = 0.003
Identities = 29/102 (28%), Positives = 47/102 (46%), Gaps = 5/102 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F+ PL V ++G+ LQCKV G P+ I+W + S+ Y + +
Sbjct: 7020 PYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKL----RSAPAYKM-QFKNNV 7074
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAP 2572
+L I + D G Y+C A N G ++SA + ++ P
Sbjct: 7075 ASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLPP 7116
Score = 43.5 bits (101), Expect = 0.003
Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 2/94 (2%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL--DTY 2626
P P P +++S + L W P S G I GY VE ++ G+ W + L
Sbjct: 17804 PGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCA 17863
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
+ L G Y+FR+ A+N G P E +E V
Sbjct: 17864 FRVPGLIEGNEYRFRIKAANIVGEGEPRELAESV 17897
Score = 43.5 bits (101), Expect = 0.003
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 4/89 (4%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYL 2627
P PI +R+ + L+W P G I+GY VE R+ W + S + ++T
Sbjct: 23523 PPGTPEPIMVKRN--EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQF 23580
Query: 2628 VIEDLSPGCPYQFRVSASNPWG-ISLPSE 2655
+ L+ Y+FRV A N G IS PS+
Sbjct: 23581 TVSGLTEDQRYEFRVIAKNAAGAISKPSD 23609
Score = 43.5 bits (101), Expect = 0.003
Identities = 27/111 (24%), Positives = 45/111 (40%), Gaps = 5/111 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P + L D T K G P+PT W + I Y +S D G
Sbjct: 32852 PVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAI----TQGGKYKLSE-DKGG 32906
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERS 2581
L+I DSG+YTC N G+ S+S + ++ + + ++ +++
Sbjct: 32907 FFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKT 32957
Score = 43.1 bits (100), Expect = 0.004
Identities = 42/167 (25%), Positives = 63/167 (37%), Gaps = 18/167 (10%)
Query: 2501 TITWKGPD--------QNILDTDNSSATY---TVSSCDSGEITLKICNLMPQDSGIYTCI 2549
T+TW P+ Q IL+ +T +S E K+ L + + +
Sbjct: 28169 TLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVM 28228
Query: 2550 ATNDHGTTSTSATVKV------QGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
A N G S ++ P P + S T+V L W P G I GY
Sbjct: 28229 AENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGY 28288
Query: 2604 TVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVSASNPWG 2649
+E + W + + + + T + DL G Y+FRVSA N G
Sbjct: 28289 IIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAG 28335
Score = 42.7 bits (99), Expect = 0.005
Identities = 37/153 (24%), Positives = 66/153 (43%), Gaps = 11/153 (7%)
Query: 2459 EILNPNFIQEVAPEFLV-PLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNS 2517
E+++P+ V P ++ PL D G QC+V G ++W D+ I
Sbjct: 3332 EVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLK-VSWYSKDKKI----KP 3386
Query: 2518 SATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA 2577
S + ++ + L+I P+D G YT +A+N G S++A + ++ + + I
Sbjct: 3387 SRFFRMTQFED-TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIE 3445
Query: 2578 Q----ERSCTSVILRWLPPSSTGNCTISGYTVE 2606
Q E VI R + P ++ +T E
Sbjct: 3446 QEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCE 3478
Score = 42.7 bits (99), Expect = 0.005
Identities = 27/96 (28%), Positives = 47/96 (48%), Gaps = 6/96 (6%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITW-KGPDQNILDTDNSSATYTVSSCDSG 2529
P F+ L D++ ++G V LQ + G ++ W K + + ++DN +Y+ +
Sbjct: 7492 PRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIA--- 7548
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV 2565
TL+ + P ++G YTC ND G AT+ V
Sbjct: 7549 --TLQFSRVEPANAGKYTCQIKNDAGMQECFATLSV 7582
Score = 42.7 bits (99), Expect = 0.005
Identities = 52/190 (27%), Positives = 80/190 (42%), Gaps = 25/190 (13%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F+ L V +GD+ LQC++ G P+ ++W D + T TY + +
Sbjct: 7961 PYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPT----TTYKM-HFRNNV 8015
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHG--TTSTSATVKVQGVPAAPNRPI--AQERSCTSVI 2586
TL + DSG Y C A N G + ST TV+ Q +P + +R + QE V+
Sbjct: 8016 ATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVV 8075
Query: 2587 LRWLPPSSTGNCTISG---YTVEYREEGSQIWQQSVAST--LD--TYLVIEDLSPGCPYQ 2639
+C ISG +V + ++G + T LD L I Q
Sbjct: 8076 F---------DCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQ 8126
Query: 2640 FRVSASNPWG 2649
+ +A+NP G
Sbjct: 8127 YSCTATNPIG 8136
Score = 42.7 bits (99), Expect = 0.005
Identities = 23/65 (35%), Positives = 31/65 (47%)
Query: 2587 LRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASN 2646
L+W P G I+ Y VE R+ + WQ + DT + L+ G Y FRV+A N
Sbjct: 14102 LKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAEN 14161
Query: 2647 PWGIS 2651
G S
Sbjct: 14162 AIGQS 14166
Score = 42.0 bits (97), Expect = 0.009
Identities = 29/97 (29%), Positives = 42/97 (43%), Gaps = 5/97 (5%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G V+ C++ G P P I W + I + N S S +L+I N DSG
Sbjct: 33148 GQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSI-----SRSRNVYSLEIRNASVSDSG 33202
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERS 2581
YT A N G S +A++ V + P+R + S
Sbjct: 33203 KYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTS 33239
Score = 41.6 bits (96), Expect = 0.012
Identities = 27/94 (28%), Positives = 45/94 (47%), Gaps = 5/94 (5%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLM 2539
+T +G+T L+CKV G P+ ++ W D +L + + S L+I ++
Sbjct: 5713 MTVTVGETCTLECKVAGTPELSVEWY-KDGKLLTSSQKHKFSFYNKISS----LRILSVE 5767
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPN 2573
QD+G YT N+ G +S +A V V P+
Sbjct: 5768 RQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPS 5801
Score = 41.2 bits (95), Expect = 0.016
Identities = 28/106 (26%), Positives = 46/106 (43%), Gaps = 5/106 (4%)
Query: 2467 QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
+++ P F L D+ +G V L C++ G + W + D +N ++
Sbjct: 6171 RQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFV---- 6226
Query: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAP 2572
TLKI SG Y+C A+N GT S+SA + + +P
Sbjct: 6227 -DNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSP 6271
Score = 40.8 bits (94), Expect = 0.020
Identities = 45/179 (25%), Positives = 78/179 (43%), Gaps = 30/179 (16%)
Query: 2455 NTSME----ILNPNFIQEV------APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITW 2504
N S+E IL+ QE+ AP + + LG C++ P W
Sbjct: 3430 NLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQW 3489
Query: 2505 KGPDQNILDTDNSS--ATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSAT 2562
+ I ++D S ++ +SS L+I D G YTC A+N++G+ S +AT
Sbjct: 3490 FKAGREIYESDKCSIRSSKYISS-------LEILRTQVVDCGEYTCKASNEYGSVSCTAT 3542
Query: 2563 VKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVAS 2621
+ V A P +++ +S T+ + + ++ CT++G V IWQ+ A+
Sbjct: 3543 LTV--TEAYPPTFLSRPKSLTTFVGK----AAKFICTVTGTPVI-----ETIWQKDGAA 3590
Score = 40.8 bits (94), Expect = 0.020
Identities = 26/95 (27%), Positives = 45/95 (47%), Gaps = 5/95 (5%)
Query: 2467 QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
Q++ P F L DV +G V+ C + G +++W + + D+ N ++ ++
Sbjct: 8053 QKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTA 8112
Query: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSA 2561
TL I +G Y+C ATN G+ S+SA
Sbjct: 8113 -----TLNIFKTDRSLAGQYSCTATNPIGSASSSA 8142
Score = 40.4 bits (93), Expect = 0.026
Identities = 25/96 (26%), Positives = 44/96 (45%), Gaps = 5/96 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F + L V ++G++ +C V G ++W + I S Y +S ++
Sbjct: 8153 PFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREI----RSGGKYQISYLENSA 8208
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
L + + DSG YTC A N+ G S +A + ++
Sbjct: 8209 -HLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIK 8243
Score = 40.4 bits (93), Expect = 0.026
Identities = 41/170 (24%), Positives = 65/170 (38%), Gaps = 23/170 (13%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVS----------SCDSGEITLKI--CNLMPQDSGIYTC 2548
TI+W+ P LD S T + S + ++T ++ NL+ + +
Sbjct: 18019 TISWENP----LDNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRV 18074
Query: 2549 IATNDHGTTSTSAT------VKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISG 2602
A N G T T + P P ++ T V L+W P G
Sbjct: 18075 CAENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLS 18134
Query: 2603 YTVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGIS 2651
Y VE R +GS W++ S +T+ +++ Y+FRV N G S
Sbjct: 18135 YHVERRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNEGGES 18184
Score = 40.4 bits (93), Expect = 0.026
Identities = 43/191 (22%), Positives = 74/191 (38%), Gaps = 19/191 (9%)
Query: 2376 VPGSILAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNK 2435
VP S+ LT+ A S S KK+ + + + T E+ + K
Sbjct: 32480 VPRSVFPELTRTEAYAVS--SFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMK 32537
Query: 2436 VSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVC 2495
+ E S EE +T+ +I +A L +T G++ C
Sbjct: 32538 SAALEEKSLEEK-------STTRKIKTT-----LAARILTKPRSMTVYEGESARFSCDTD 32585
Query: 2496 GRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHG 2555
G P PT+TW Q + ++SA + V++ + T +I ++ D G Y+ + N G
Sbjct: 32586 GEPVPTVTWLRKGQVL----STSARHQVTT-TKYKSTFEISSVQASDEGNYSVVVENSEG 32640
Query: 2556 TTSTSATVKVQ 2566
T+ +Q
Sbjct: 32641 KQEAEFTLTIQ 32651
Score = 40.0 bits (92), Expect = 0.035
Identities = 30/105 (28%), Positives = 43/105 (40%), Gaps = 3/105 (2%)
Query: 2468 EVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCD 2527
+V P F+ L +V G + ++ + G P P I W I+ +
Sbjct: 1553 QVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTK-- 1610
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAP 2572
GE LKI + + QDS YT A N G +T V V+ A P
Sbjct: 1611 -GEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEP 1654
Score = 40.0 bits (92), Expect = 0.035
Identities = 25/96 (26%), Positives = 40/96 (41%), Gaps = 5/96 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F+ + + L G T Q + G T+TW I + DN T+ ++
Sbjct: 4486 PSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTF-----ENNV 4540
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
+L + + + G Y C A ND G SA + V+
Sbjct: 4541 ASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVK 4576
Score = 40.0 bits (92), Expect = 0.035
Identities = 30/105 (28%), Positives = 47/105 (44%), Gaps = 6/105 (5%)
Query: 2465 FIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVS 2524
F++E A FL L D + G ++IL+ G ++TWK NI ++ + T
Sbjct: 5981 FVKEPAA-FLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEK 6039
Query: 2525 SCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVP 2569
+C L+I N +D+G Y+C N+ G A V P
Sbjct: 6040 TC-----ILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPP 6079
Score = 39.7 bits (91), Expect = 0.045
Identities = 36/149 (24%), Positives = 60/149 (40%), Gaps = 17/149 (11%)
Query: 2433 GNKVSVKETNSSEESECDDLDPNTSMEIL------------NPNFIQEVAPEFLVPLVDV 2480
G++ +V +S E E D+D + S E + + +F+ L D
Sbjct: 7818 GDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDY 7877
Query: 2481 TCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMP 2540
+ G +IL+ G P ++TWK N+ + + T T S L+I +
Sbjct: 7878 SIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSA-----ILEIPSSTV 7932
Query: 2541 QDSGIYTCIATNDHGTTSTSATVKVQGVP 2569
+D+G Y C N G S SA + + P
Sbjct: 7933 EDAGQYNCYIENASGKDSCSAQILILEPP 7961
Score = 39.3 bits (90), Expect = 0.059
Identities = 27/88 (30%), Positives = 39/88 (44%), Gaps = 1/88 (1%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTY 2626
VP P +E + +V L W PP G I Y +E R G++ + + L
Sbjct: 16716 VPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRK 16775
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPS 2654
++ L G Y++RVSA N G PS
Sbjct: 16776 YTVKGLKEGDTYEYRVSAVNIVGQGKPS 16803
Score = 38.1 bits (87), Expect = 0.13
Identities = 31/96 (32%), Positives = 43/96 (44%), Gaps = 7/96 (7%)
Query: 2478 VDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICN 2537
+DVT GD LQ K G + T W Q + + Y +S D+ I LKI +
Sbjct: 4588 IDVT--QGDPATLQVKFSGTKEITAKWFKDGQEL----TLGSKYKISVTDTVSI-LKIIS 4640
Query: 2538 LMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPN 2573
+DSG YT ND G +S A + V + P+
Sbjct: 4641 TEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPS 4676
Score = 38.1 bits (87), Expect = 0.13
Identities = 31/110 (28%), Positives = 43/110 (39%), Gaps = 8/110 (7%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQ--QSVASTLDTY 2626
P P P + S +S+ + W P G I+GY VE WQ A T
Sbjct: 21756 PGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATS 21815
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGIS----LPSEPSEFVRL--PEYDAAAD 2670
I L+ Y+ R+ A N G+ +P P R+ PE + AD
Sbjct: 21816 YTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDAD 21865
Score = 37.7 bits (86), Expect = 0.17
Identities = 29/105 (27%), Positives = 47/105 (44%), Gaps = 5/105 (4%)
Query: 2466 IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSS 2525
I + +P F + L V+L +V G P ITW D IL + T+
Sbjct: 4388 IVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWF-KDNTILRSGRKYKTFIQDH 4446
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPA 2570
++L+I + D+G Y C TN+ G++ SA V ++ P+
Sbjct: 4447 L----VSLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPPS 4487
Score = 37.4 bits (85), Expect = 0.22
Identities = 42/164 (25%), Positives = 70/164 (42%), Gaps = 22/164 (13%)
Query: 2411 RAEVENTGKNEATGPRKPKDILGNK------------VSVKETNSSE--ESECDDLDPNT 2456
+ EV TG E + + K I +K + + NS++ E EC +
Sbjct: 3851 QCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANEVG 3910
Query: 2457 SMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITW-KGPDQNILDTD 2515
+ + ++E P F+ + D+ L G TV LQ V G ++TW KG Q ++ D
Sbjct: 3911 KCGCMATHLLKE-PPTFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMKG--QEVIRED 3967
Query: 2516 NSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTST 2559
S +G L I ++ G YTC+A N+ G+ ++
Sbjct: 3968 GK----IKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTS 4007
Score = 37.4 bits (85), Expect = 0.22
Identities = 34/131 (25%), Positives = 58/131 (44%), Gaps = 10/131 (7%)
Query: 2441 TNSSEESECDDLDPNTSMEILNPNFIQEVAPEF--LVPLVDVTCLLGDTVILQCKVCGRP 2498
T S + C+ +P S ++E P F P+V+ L V L+C++ G P
Sbjct: 5488 TEDSGDFICEAQNPAGSTSCSTKVIVKE-PPVFSSFPPIVET--LKNAEVSLECELSGTP 5544
Query: 2499 KPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTS 2558
+ W + + SS Y ++S + ++ I N+ D G Y C A N+ G+ +
Sbjct: 5545 PFEVVWYKDKRQL----RSSKKYKIAS-KNFHTSIHILNVDTSDIGEYHCKAQNEVGSDT 5599
Query: 2559 TSATVKVQGVP 2569
TVK++ P
Sbjct: 5600 CVCTVKLKEPP 5610
Score = 37.4 bits (85), Expect = 0.22
Identities = 23/101 (22%), Positives = 47/101 (46%), Gaps = 9/101 (8%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G++ L+ +V G T+ W + I T N T+ + + L++ D+G
Sbjct: 8264 GNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFK-----NNTLVLQVRKAGMNDAG 8318
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSV 2585
+YTC +ND G+ ++++ ++ P +P ++ T V
Sbjct: 8319 LYTCKVSNDAGSALCTSSIVIK----EPKKPPVFDQHLTPV 8355
Score = 37.0 bits (84), Expect = 0.29
Identities = 26/99 (26%), Positives = 42/99 (42%), Gaps = 5/99 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P FL +T +G C V G P W+ + + N + +S ++
Sbjct: 3551 PTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPN----WRISDAENKH 3606
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVP 2569
I L++ NL QD G+Y+C A+N G A + + P
Sbjct: 3607 I-LELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKP 3644
Score = 37.0 bits (84), Expect = 0.29
Identities = 58/257 (22%), Positives = 97/257 (37%), Gaps = 32/257 (12%)
Query: 2325 SMAVIKDYYALKENEIC-VSQGEVVQVLAVNQ-------QNMCLVYQPASDHSPAAEGWV 2376
S++ IKD Y + ++E C ++ E +L + + Q CL+ A A V
Sbjct: 6957 SVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICEALVSV 7016
Query: 2377 --PGSILAPLTK--------ATAAESSDGSIKKSCSWHT--LRMRKRAEVENTGKNEATG 2424
P + PL AT DG+ + SW+ ++R + KN
Sbjct: 7017 LEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVAS 7076
Query: 2425 PRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLL 2484
++ NKV + + + S +L +++ P F L DV L
Sbjct: 7077 ------LVINKVDHSDVGEYSCKADNSVGAVASSAVLVIK-ARKLPPFFARKLKDVHETL 7129
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G V +C++ G ++W + D N ++ + TL+I G
Sbjct: 7130 GFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVA-----TLQILQTDQSHIG 7184
Query: 2545 IYTCIATNDHGTTSTSA 2561
Y C A+N GT S+SA
Sbjct: 7185 QYNCSASNPLGTASSSA 7201
Score = 36.6 bits (83), Expect = 0.38
Identities = 25/96 (26%), Positives = 42/96 (43%), Gaps = 6/96 (6%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITW-KGPDQNILDTDNSSATYTVSSCDSG 2529
P F+ L +T + G+ LQ + G + W K ++ I +++N T+ +
Sbjct: 5610 PRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVA--- 5666
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV 2565
TL+ P ++G Y C ND G AT+ V
Sbjct: 5667 --TLQFAKAEPANAGKYICQIKNDGGMRENMATLMV 5700
Score = 36.6 bits (83), Expect = 0.38
Identities = 27/96 (28%), Positives = 45/96 (46%), Gaps = 6/96 (6%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITW-KGPDQNILDTDNSSATYTVSSCDSG 2529
P F+ L D + L+GD V L+ V G ++ W K + I +++N+ ++
Sbjct: 6551 PRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFI-----DN 6605
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV 2565
TL++ + +SG Y C ND G SA + V
Sbjct: 6606 IATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTV 6641
Score = 36.6 bits (83), Expect = 0.38
Identities = 27/105 (25%), Positives = 45/105 (42%), Gaps = 6/105 (5%)
Query: 2465 FIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVS 2524
F++E A F+ L D + G ++L+ G P +++W + I ++ S T T
Sbjct: 6922 FVKEPAT-FVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEK 6980
Query: 2525 SCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVP 2569
S L+I +D Y+C+ N+ G A V V P
Sbjct: 6981 S-----TILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPP 7020
Score = 36.6 bits (83), Expect = 0.38
Identities = 48/191 (25%), Positives = 71/191 (37%), Gaps = 26/191 (13%)
Query: 2501 TITWKGPDQN--------ILDTDNSSATYTVSSCDSGEIT---LKICNLMPQDSGIYTCI 2549
T+ W PD + I++ + S + C+ IT L++ L +
Sbjct: 23836 TVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIK-CNKRRITDLRLRVTGLTEDHEYEFRVS 23894
Query: 2550 ATNDHGTTSTS-ATVKVQGV-----PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
A N G S ATV + P P + + S+ L W P G I GY
Sbjct: 23895 AENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGY 23954
Query: 2604 TVEYREEGSQIWQQSVAST--LDTYLVIEDLSPGCPYQFRVSASNPWGI----SLPS--E 2655
VE + + WQ T T I L+ Y+ RV A N G+ S+P +
Sbjct: 23955 VVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVK 24014
Query: 2656 PSEFVRLPEYD 2666
P + + PE D
Sbjct: 24015 PEDKLEAPELD 24025
Score = 36.2 bits (82), Expect = 0.50
Identities = 26/92 (28%), Positives = 38/92 (41%), Gaps = 5/92 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F+ L + G +LQC+V G I+W + I SS Y + S
Sbjct: 3831 PSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQI----RSSKKYRLFS-QKSL 3885
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSAT 2562
+ L+I + D G Y C+ N+ G AT
Sbjct: 3886 VCLEIFSFNSADVGEYECVVANEVGKCGCMAT 3917
Score = 36.2 bits (82), Expect = 0.50
Identities = 47/199 (23%), Positives = 71/199 (35%), Gaps = 20/199 (10%)
Query: 2381 LAPLTKATAAESSDGSIKKSCSWHTLRMR---KRAEVENTGKNEATGPRKPKDILGNKVS 2437
L PL TA E S +R++ + T K I +S
Sbjct: 11932 LTPLKDVTAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLS 11991
Query: 2438 VKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGR 2497
+ +T S E + + +L E P F L D T + D VILQC++
Sbjct: 11992 IDDT-SQIRVEAMGMSSEAKLTVL------EGDPYFTGKLQDYTGVEKDEVILQCEISKA 12044
Query: 2498 PKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTT 2557
P + W + I + N+ V D + L + + D G YTC D GT
Sbjct: 12045 DAP-VKWFKDGKEIKPSKNA-----VIKADGKKRMLILKKALKSDIGQYTC----DCGTD 12094
Query: 2558 STSATVKVQGVPAAPNRPI 2576
TS + ++ RP+
Sbjct: 12095 KTSGKLDIEDREIKLVRPL 12113
Score = 35.8 bits (81), Expect = 0.65
Identities = 24/69 (34%), Positives = 33/69 (47%), Gaps = 3/69 (4%)
Query: 2499 KPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTS 2558
KPT K + ++S YT +S G +TL+I + DSG Y + TN G S
Sbjct: 32400 KPTAEVKWYHNGVELQESSKIHYTNTS---GVLTLEILDCHTDDSGTYRAVCTNYKGEAS 32456
Query: 2559 TSATVKVQG 2567
AT+ V G
Sbjct: 32457 DYATLDVTG 32465
Score = 35.4 bits (80), Expect = 0.85
Identities = 28/115 (24%), Positives = 52/115 (45%), Gaps = 12/115 (10%)
Query: 2455 NTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDT 2514
+TS+++ P P F + L G V L+C++ G P ++W + +
Sbjct: 7390 STSLKVKEP-------PIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKREL--- 7439
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVP 2569
S Y + S ++ ++ I N+ D G Y C ATND G+ + ++ ++ P
Sbjct: 7440 -RSGKKYKIMS-ENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPP 7492
Score = 35.4 bits (80), Expect = 0.85
Identities = 29/96 (30%), Positives = 41/96 (42%), Gaps = 7/96 (7%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIED 2631
P +P + + ++V L W P G I GY VE + W + +T + E+
Sbjct: 19193 PGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVR--CNTAPHQIPQEE 19250
Query: 2632 -----LSPGCPYQFRVSASNPWGISLPSEPSEFVRL 2662
L YQFR A IS PSEPS+ V +
Sbjct: 19251 YTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTI 19286
Score = 35.0 bits (79), Expect = 1.1
Identities = 23/80 (28%), Positives = 36/80 (45%), Gaps = 6/80 (7%)
Query: 2487 TVILQCKVCGRPKPTITW-KGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGI 2545
T KV G P P + W KG + + N + E L+I + DSG+
Sbjct: 8470 TATFIAKVGGDPIPNVKWTKGKWRQL----NQGGRVFIHQ-KGDEAKLEIRDTTKTDSGL 8524
Query: 2546 YTCIATNDHGTTSTSATVKV 2565
Y C+A N+HG ++ ++V
Sbjct: 8525 YRCVAFNEHGEIESNVNLQV 8544
Score = 34.3 bits (77), Expect = 1.9
Identities = 16/26 (61%), Positives = 20/26 (76%)
Query: 2541 QDSGIYTCIATNDHGTTSTSATVKVQ 2566
+DSGI TC ATN +GT TSAT+ V+
Sbjct: 1770 RDSGIITCRATNKYGTDHTSATLIVK 1795
Score = 34.3 bits (77), Expect = 1.9
Identities = 37/147 (25%), Positives = 63/147 (42%), Gaps = 21/147 (14%)
Query: 2434 NKVSVKETN----SSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVI 2489
+K+ +KE S +++ +L +++L E P F V L D T + D +
Sbjct: 11628 HKLEMKEVTLDDISQIKAQVKELSSTAQLKVL------EADPYFTVKLHDKTAVEKDEIT 11681
Query: 2490 LQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
L+C+V + P +K ++ + S Y++ + D LKI +D G Y C
Sbjct: 11682 LKCEV-SKDVPVKWFKDGEEIV-----PSPKYSIKA-DGLRRILKIKKADLKDKGEYVC- 11733
Query: 2550 ATNDHGTTSTSATVKVQGVPAAPNRPI 2576
D GT T A V V+ +P+
Sbjct: 11734 ---DCGTDKTKANVTVEARLIKVEKPL 11757
Score = 33.5 bits (75), Expect = 3.2
Identities = 23/85 (27%), Positives = 39/85 (45%), Gaps = 6/85 (7%)
Query: 2485 GDTVILQCKVCGRPKPT-ITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDS 2543
G V CK+ + T +TW + + +++ TY + G L + ++ D
Sbjct: 31582 GGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITY-----EDGVAILYVKDITKLDD 31636
Query: 2544 GIYTCIATNDHGTTSTSATVKVQGV 2568
G Y C ND+G S+ A + V+GV
Sbjct: 31637 GTYRCKVVNDYGEDSSYAELFVKGV 31661
Score = 32.3 bits (72), Expect = 7.2
Identities = 34/154 (22%), Positives = 61/154 (39%), Gaps = 22/154 (14%)
Query: 2407 RMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFI 2466
R++ V++ + ++ P PK VS ET + + L + P
Sbjct: 32672 RVKSPEAVKSPKRVKSPEPSHPK-----AVSPTETKPTPTEKVQHLPVSAP-----PKIT 32721
Query: 2467 QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
Q + E + +TC++ +V+ R K +TW + + + + Y+
Sbjct: 32722 QFLKAEASKEIAKLTCVVESSVL-------RAKE-VTWYKDGKKLKENGHFQFHYSAD-- 32771
Query: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTS 2560
G LKI NL D G Y C + + GT+ T+
Sbjct: 32772 --GTYELKINNLTESDQGEYVCEISGEGGTSKTN 32803
>gi|110349717 titin isoform novex-2 [Homo sapiens]
Length = 27118
Score = 231 bits (588), Expect = 1e-59
Identities = 152/487 (31%), Positives = 240/487 (49%), Gaps = 26/487 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P+ L + V L G+ V ++ G+P P ITW+ Q+++D + S S
Sbjct: 24723 PKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQ-KGQDLIDNNGHYQVIVTRSFTS-- 24779
Query: 2531 ITLKICN-LMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRW 2589
L N + +D+G Y A N G + + V VP P + S SV L W
Sbjct: 24780 --LVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTW 24837
Query: 2590 LPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG 2649
P+S G I+ Y VE ++ W + V +T + +L YQFRV A N +G
Sbjct: 24838 TEPASDGGSKITNYIVEKCATTAERWLR-VGQARETRYTVINLFGKTSYQFRVIAENKFG 24896
Query: 2650 ISLPSEPSE-------FVRLPEYDAAAD---------GATISWKENFDSAYTELNEIGRG 2693
+S PSEPSE R YD D + S KE ++ Y ++GRG
Sbjct: 24897 LSKPSEPSEPTITKEDKTRAMNYDEEVDETREVSMTKASHSSTKELYEK-YMIAEDLGRG 24955
Query: 2694 RFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSY 2753
F IV +C+ +++K KFV K + E ++L +H + LH+++ES
Sbjct: 24956 EFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISILNIARHRNILHLHESFESMEEL 25015
Query: 2754 ILILELMDDGRLLDYLMNHD-ELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLID 2812
++I E + + + + EL E ++ Y+ + EALQ+LH+ + H DI+PEN++
Sbjct: 25016 VMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHFDIRPENIIYQ 25075
Query: 2813 LRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYV 2872
R +K+I+ A Q+ + L PE+ APEV Q VS TD+WS+G L YV
Sbjct: 25076 TRRS-STIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDMWSLGTLVYV 25134
Query: 2873 MLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATC 2932
+LSG++PFL E+ ++ N+ +++F E F +S A DF++ +L ++ + R TA+
Sbjct: 25135 LLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSRMTASEA 25194
Query: 2933 LQHPWLQ 2939
LQHPWL+
Sbjct: 25195 LQHPWLK 25201
Score = 101 bits (251), Expect = 1e-20
Identities = 68/214 (31%), Positives = 93/214 (43%), Gaps = 18/214 (8%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLM 2539
+TC G + + GRP P +TWK + + +TD S T T TL + + M
Sbjct: 22352 ITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTT-----KDRTTLTVKDSM 22406
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPI-AQERSCTSVILRWLPPSSTGNC 2598
DSG Y N G + S TV V G P PI S S +L W P G
Sbjct: 22407 RGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIEVSSVSAESCVLSWGEPKDGGGT 22466
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE--- 2655
I+ Y VE RE G+ WQ +S T + + L+ Y FRVS+ N +G+S P E
Sbjct: 22467 EITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAP 22526
Query: 2656 ---------PSEFVRLPEYDAAADGATISWKENF 2680
PS R Y +A+ +I W+E +
Sbjct: 22527 IIAEHPFVPPSAPTRPEVYHVSANAMSIRWEEPY 22560
Score = 97.4 bits (241), Expect = 2e-19
Identities = 68/211 (32%), Positives = 89/211 (42%), Gaps = 26/211 (12%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
GD + ++ V GRPKPT+TWK DQ + T + T +S L I + DSG
Sbjct: 14775 GDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATST-----ILNINECVRSDSG 14829
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTISGY 2603
Y A N G T++V +P P PI E S V W PP + G IS Y
Sbjct: 14830 PYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNY 14889
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI------------- 2650
VE R+ S W + + + T L+ G YQFRV A N +G+
Sbjct: 14890 VVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANY 14949
Query: 2651 --SLPSEPSEFVRLPEYDAAA-DGATISWKE 2678
+P P P+ A D TISW E
Sbjct: 14950 PFKVPGPPG----TPQVTAVTKDSMTISWHE 14976
Score = 94.4 bits (233), Expect = 2e-18
Identities = 59/186 (31%), Positives = 85/186 (45%), Gaps = 6/186 (3%)
Query: 2469 VAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDS 2528
+ P +P + G+ + ++ V GRP+P I+W + + T + T +S
Sbjct: 18005 IQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATST-- 18062
Query: 2529 GEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVIL 2587
L I D G YT ATN GT + + +V V P P P+ E S V++
Sbjct: 18063 ---VLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVI 18119
Query: 2588 RWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNP 2647
W PP+ TG C IS Y VE R+ + W A+ T + I L G YQFR+ A N
Sbjct: 18120 SWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENR 18179
Query: 2648 WGISLP 2653
+G S P
Sbjct: 18180 YGKSAP 18185
Score = 92.0 bits (227), Expect = 8e-18
Identities = 64/202 (31%), Positives = 91/202 (45%), Gaps = 17/202 (8%)
Query: 2487 TVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIY 2546
T+ L + GRP+P + W+ + + D T S L I N+ DSG Y
Sbjct: 18819 TLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVT-------SSFTMLVIDNVTRFDSGRY 18871
Query: 2547 TCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVE 2606
N+ G+ + V+V P+AP +E SV L W PP G I+ Y VE
Sbjct: 18872 NLTLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVE 18931
Query: 2607 YREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE-- 2664
RE + + + T IE+L GC Y FRV ASN +GI LP+E +E V++ E
Sbjct: 18932 KRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPP 18991
Query: 2665 --------YDAAADGATISWKE 2678
D + ATI W++
Sbjct: 18992 LPPGRVTLVDVTRNTATIKWEK 19013
Score = 91.7 bits (226), Expect = 1e-17
Identities = 61/196 (31%), Positives = 83/196 (42%), Gaps = 27/196 (13%)
Query: 2496 GRPKPTITWKGPDQNI-----LDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIA 2550
GRP PT W PD N+ + T +S +T TV +C+ D+G YT
Sbjct: 22078 GRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRN------------DAGKYTLTV 22125
Query: 2551 TNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREE 2610
N+ G+ S + TVKV P P ++ + S L W P G I Y VE RE
Sbjct: 22126 ENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKREA 22185
Query: 2611 GSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV---------- 2660
+ WQ + DL+ G PY FRVSA N +G+ P E E +
Sbjct: 22186 SRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPR 22245
Query: 2661 RLPEYDAAADGATISW 2676
RL D + A ++W
Sbjct: 22246 RLDVVDTSKSSAVLAW 22261
Score = 90.5 bits (223), Expect = 2e-17
Identities = 85/288 (29%), Positives = 125/288 (43%), Gaps = 34/288 (11%)
Query: 2414 VENTGKNEAT----GPRKPKDILGNKV---SVKETNSSEESECDDLDPNTSMEILNPNFI 2466
VE GK E T G K +I +++ SV E ++E DP T + P +
Sbjct: 21194 VERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVT----IGPITV 21249
Query: 2467 QE--VAPEFL---VPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATY 2521
+E + PE +P VT +G V L+ G+PKP+I+W + +++ +
Sbjct: 21250 KELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESE-----F 21304
Query: 2522 TVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QER 2580
S +ITL I N + G YT I N + TV G P+ P PI E
Sbjct: 21305 VRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKGPIRFDEI 21364
Query: 2581 SCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQF 2640
SVIL W P G I+ Y++E RE W+ +S T + +L YQF
Sbjct: 21365 KADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQF 21424
Query: 2641 RVSASNPWGISLPSEPSEFV-----RLPE-------YDAAADGATISW 2676
RV A N +G+S P S V R+P Y+ +DG +++W
Sbjct: 21425 RVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSLTW 21472
Score = 88.6 bits (218), Expect = 8e-17
Identities = 60/195 (30%), Positives = 85/195 (43%), Gaps = 9/195 (4%)
Query: 2468 EVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTD--NSSATYTVSS 2525
E+ P +P + + + GRP+ T+ W+ Q + +T N S++ TV+S
Sbjct: 19087 EIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTS 19146
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSV 2585
L I +D G Y +N G+ + T+ V P P E SC S+
Sbjct: 19147 -------LSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSI 19199
Query: 2586 ILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSAS 2645
+ W PP G C IS Y VE +E S W + T + I L+ G YQFRV A
Sbjct: 19200 TISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAE 19259
Query: 2646 NPWGISLPSEPSEFV 2660
N +G S SE S V
Sbjct: 19260 NRYGKSSYSESSAVV 19274
Score = 88.2 bits (217), Expect = 1e-16
Identities = 101/420 (24%), Positives = 157/420 (37%), Gaps = 60/420 (14%)
Query: 2422 ATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSM-EILNPNFIQEVAPEFLVPLVDV 2480
ATG + ++ N S SE D P T + E + P VA + L+
Sbjct: 12948 ATGLEEKAQYQFRAIARTAVNISPPSEPSD--PVTILAENVPPRIDLSVAMKSLL----- 13000
Query: 2481 TCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMP 2540
T G V L V G+P PT++WK + + + C TL++ ++
Sbjct: 13001 TVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLC-----TLELFSVNR 13055
Query: 2541 QDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTI 2600
+DSG YT A N G+ S + +KV P P + +L W PP G I
Sbjct: 13056 KDSGDYTITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEI 13115
Query: 2601 SGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
+ Y V+ RE W Q A+ T +E L G YQFR+ A N +G+ P +
Sbjct: 13116 TNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAI 13175
Query: 2661 RLPEYD------------AAADGATISWKENFDSA------------------YTELNEI 2690
YD D T+SWK D +T++N
Sbjct: 13176 AKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRK 13235
Query: 2691 GRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQH----PQYITLHDT 2746
++ + + T + V ++K K A +AA + Q+ P + ++DT
Sbjct: 13236 PIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDT 13295
Query: 2747 YESPTSYILILELMDDGR-LLDYLM-----NHDELME-------EKVAFYIRDIMEALQY 2793
S S D G ++ YL+ + D + +K F + +ME QY
Sbjct: 13296 TRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQY 13355
Score = 87.8 bits (216), Expect = 1e-16
Identities = 60/202 (29%), Positives = 88/202 (43%), Gaps = 17/202 (8%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G ++ L + GRP P + W D I D T + +S L + N+ DSG
Sbjct: 16652 GGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTS-------LVLDNVNRYDSG 16704
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
YT N GT S TV+V P+ P E + SV + W PP G I Y
Sbjct: 16705 KYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYI 16764
Query: 2605 VEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
VE RE + + V + I+ L GC Y FRV+A N +GI LP++ ++ +++ E
Sbjct: 16765 VEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAE 16824
Query: 2665 Y----------DAAADGATISW 2676
D + ++SW
Sbjct: 16825 VPQPPGKITVDDVTRNSVSLSW 16846
Score = 87.4 bits (215), Expect = 2e-16
Identities = 61/204 (29%), Positives = 89/204 (43%), Gaps = 21/204 (10%)
Query: 2487 TVILQCKVCGRPKPTITWKGPDQNILDTDN--SSATYTVSSCDSGEITLKICNLMPQDSG 2544
T+ L + GRP P + W LD + S+++YT+ L + N+ DSG
Sbjct: 15572 TLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTL---------LIVGNVNRFDSG 15622
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
Y N G+ S V+V P P +E + TSV L W PP G I Y
Sbjct: 15623 KYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYI 15682
Query: 2605 VEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
VE RE + + + T ++ L GC Y FRV A N +GI LP+E +E V+ E
Sbjct: 15683 VEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASE 15742
Query: 2665 ----------YDAAADGATISWKE 2678
D + ++SW++
Sbjct: 15743 RPLPPGKITLMDVTRNSVSLSWEK 15766
Score = 85.5 bits (210), Expect = 7e-16
Identities = 74/282 (26%), Positives = 117/282 (41%), Gaps = 36/282 (12%)
Query: 2453 DPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVC--------GRPKPTITW 2504
DP+ S + P +E E PL D+ + T+I++ GRP P + W
Sbjct: 19862 DPSDSSD---PQIAKEREEE---PLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLW 19915
Query: 2505 KGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVK 2564
PD TD + Y V + DS +L I N DSG YT N S + VK
Sbjct: 19916 SKPD-----TDLRTRAY-VDTTDS-RTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVK 19968
Query: 2565 VQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLD 2624
V P P Q+ + S +L W P + G + Y +E RE + W +
Sbjct: 19969 VLDTPGPPTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNR 20028
Query: 2625 TYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDA----------AADGATI 2674
+ +L G Y FRVS N +G+ +P+E E V++ E + + D ++
Sbjct: 20029 LSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSL 20088
Query: 2675 SW-KENFDS----AYTELNEIGRGRFSIVKKCIHKATRKDVA 2711
+W K D + + + +G+ + VK + K+T V+
Sbjct: 20089 TWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVS 20130
Score = 85.1 bits (209), Expect = 9e-16
Identities = 64/238 (26%), Positives = 100/238 (42%), Gaps = 10/238 (4%)
Query: 2484 LGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEIT-LKICNLMPQD 2542
+G + ++ + GRPKPTITW + T + T DS ++T L I D
Sbjct: 16938 VGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVT------DSLDLTTLSIKETHKDD 16991
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTIS 2601
G Y N G + S + P P P+ + S S+ L W PP TG C I+
Sbjct: 16992 GGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQIT 17051
Query: 2602 GYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV- 2660
Y V+ R+ + +W A+ T L + L G YQFR+ A N +G S E V
Sbjct: 17052 NYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVA 17111
Query: 2661 RLPEYDAAADGATISWKENFDSAYTELNE-IGRGRFSIVKKCIHKATRKDVAVKFVSK 2717
+ P + G + + DS + +E + G ++ + + R + V+K
Sbjct: 17112 QYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNK 17169
Score = 84.7 bits (208), Expect = 1e-15
Identities = 64/201 (31%), Positives = 84/201 (41%), Gaps = 15/201 (7%)
Query: 2485 GDTVILQCKVCGRPKPTITW-----KGPDQN--ILDTDNSSATYTVSSCDSGEITLKICN 2537
G V + K+ G P PT+TW K PD +L + + +C TL I
Sbjct: 9826 GTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTC-----TLVIPQ 9880
Query: 2538 LMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTSVILRWLPPSSTG 2596
D+G+YT A N+ GT S + V G P P PI E S + L W PP G
Sbjct: 9881 SRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDG 9940
Query: 2597 NCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP--S 2654
I+ Y +E RE + W + + I L G Y FR+ A N +GI P S
Sbjct: 9941 GSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDS 10000
Query: 2655 EPSEFVRLPEYDAAADGATIS 2675
EP L A D T+S
Sbjct: 10001 EPETARNLFSVPGAPDKPTVS 10021
Score = 84.0 bits (206), Expect = 2e-15
Identities = 54/171 (31%), Positives = 82/171 (47%), Gaps = 10/171 (5%)
Query: 2490 LQCKVCGRPKPTITWK-GPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTC 2548
L+ + G+P P+++WK G D DT S + V++ TL + + D+G YT
Sbjct: 13697 LKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNT------TLIVYDCQKSDAGKYTI 13750
Query: 2549 IATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTISGYTVEY 2607
N GT + ++KV G P P PI E + ++ L+W PP G I+ Y +E
Sbjct: 13751 TLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEK 13810
Query: 2608 REEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI--SLPSEP 2656
R+ + W ++ T + L G Y FRVSA N +G+ L SEP
Sbjct: 13811 RDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEP 13861
Score = 84.0 bits (206), Expect = 2e-15
Identities = 77/295 (26%), Positives = 119/295 (40%), Gaps = 24/295 (8%)
Query: 2398 KKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTS 2457
K S W T K E TG I G + S + + +E+ D S
Sbjct: 15785 KGSDKWATCATVKVTEATITGL-----------IQGEEYSFRVSAQNEKGISDPRQ--LS 15831
Query: 2458 MEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNS 2517
+ ++ + + + P F + T L G+ + + GRP P +TW + + T
Sbjct: 15832 VPVIAKDLV--IPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRV 15889
Query: 2518 SATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA 2577
+A T ++ L I + +D G Y TN G + V V P P P+
Sbjct: 15890 NAESTENNS-----LLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVK 15944
Query: 2578 QER-SCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGC 2636
+ + S+ L W PP G +I+ Y VE R+ + WQ A+ T + L GC
Sbjct: 15945 MDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGC 16004
Query: 2637 PYQFRVSASNPWGIS--LPSEPSEFVRLPEYDAAADGATISWKENFDSAYTELNE 2689
YQFR++A N +G S L SEP+ + P G + + DS + NE
Sbjct: 16005 EYQFRIAAENRYGKSTYLNSEPT-VAQYPFKVPGPPGTPVVTLSSRDSMEVQWNE 16058
Score = 83.6 bits (205), Expect = 3e-15
Identities = 64/209 (30%), Positives = 93/209 (44%), Gaps = 17/209 (8%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G+ V + GRP PT+TW+ ++N+ S A Y++ + DS + L I + D+G
Sbjct: 20981 GEDVQVLIPFKGRPPPTVTWRKDEKNL----GSDARYSIENTDSSSL-LTIPQVTRNDTG 21035
Query: 2545 IYTCIATNDHGTT-STSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
Y N G S++ +VKV PAA + + S +V L W PP G I Y
Sbjct: 21036 KYILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINY 21095
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLP 2663
+E R+ + W T + DLS P+ FRV A N GI P E +E V+
Sbjct: 21096 VIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAA 21155
Query: 2664 EY----------DAAADGATISW-KENFD 2681
E D+ +SW K +FD
Sbjct: 21156 EVPAPIRDLSMKDSTKTSVILSWTKPDFD 21184
Score = 83.2 bits (204), Expect = 4e-15
Identities = 65/227 (28%), Positives = 90/227 (39%), Gaps = 20/227 (8%)
Query: 2470 APEFLVP---LVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
APE + L +T G + L V G+P+P ITW D IL D V
Sbjct: 7382 APEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADM-ILKQDKRITIENVPK- 7439
Query: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVI 2586
+ T+ I + D+G Y A N G + V V P P + + S +
Sbjct: 7440 ---KSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCL 7496
Query: 2587 LRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASN 2646
L W PP G I+ Y VE R S++W + ++ DT L P Y FRV+A N
Sbjct: 7497 LTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAEN 7556
Query: 2647 PWGISLPSE------------PSEFVRLPEYDAAADGATISWKENFD 2681
+G+ P + P RL D D T++W E D
Sbjct: 7557 MYGVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDD 7603
Score = 82.8 bits (203), Expect = 5e-15
Identities = 67/221 (30%), Positives = 91/221 (41%), Gaps = 18/221 (8%)
Query: 2480 VTCLLGDTVILQC-KVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNL 2538
+T GDT++L + G+P P +W ++I +D + T T +S +T+K
Sbjct: 14083 LTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS---SMLTIKYATR 14139
Query: 2539 MPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNC 2598
+D+G YT ATN GT V V VP P S L W PP G
Sbjct: 14140 --KDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGS 14197
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP--SEP 2656
I Y +E RE +W V L G Y FRVSA N +G P SEP
Sbjct: 14198 PIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEP 14257
Query: 2657 SEFV---------RLPEY-DAAADGATISWKENFDSAYTEL 2687
+ V PE + + AT+SWK D +E+
Sbjct: 14258 VKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEI 14298
Score = 82.4 bits (202), Expect = 6e-15
Identities = 57/234 (24%), Positives = 101/234 (43%), Gaps = 18/234 (7%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLM 2539
+T +G+ L + G+PKP ++W + ++L+ D + T ++ +I K
Sbjct: 10523 LTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAK----- 10577
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNC 2598
DSG Y + N G+ V V P P P++ E + +++ W PP G
Sbjct: 10578 RSDSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVTKDYMVISWKPPLDDGGS 10637
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP----- 2653
I+ Y +E +E G +W +++ T + L G Y FR+ A N +GIS P
Sbjct: 10638 KITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDS 10697
Query: 2654 SEPSEFVRLPE-------YDAAADGATISWKENFDSAYTELNEIGRGRFSIVKK 2700
+ + R+P+ + D A ++W + D N I R ++ K+
Sbjct: 10698 MKAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKPITNYILEKRETMSKR 10751
Score = 80.5 bits (197), Expect = 2e-14
Identities = 59/199 (29%), Positives = 88/199 (44%), Gaps = 8/199 (4%)
Query: 2467 QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
Q + P+ L+P +T G + ++ V G+P PT WK + ++ +S+ V
Sbjct: 12591 QLLPPKILMP-EQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVV----TSSHLAVHKA 12645
Query: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPI-AQERSCTSV 2585
DS I + I ++ +DSG Y+ A N GT + V V P P P + +
Sbjct: 12646 DSSSILI-IKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADAC 12704
Query: 2586 ILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSAS 2645
L W P G I+ Y VE + W ++AS T + L PG Y FRV A
Sbjct: 12705 SLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAE 12764
Query: 2646 NPWGISLP-SEPSEFVRLP 2663
N +GIS P + P + P
Sbjct: 12765 NRFGISEPLTSPKMVAQFP 12783
Score = 78.2 bits (191), Expect = 1e-13
Identities = 63/207 (30%), Positives = 92/207 (44%), Gaps = 22/207 (10%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSA-TYT-VSSCDSGEITLKICNLMPQD 2542
G V L + GRP P +W + +++ + T+T V+ E T++ D
Sbjct: 23448 GRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIR-------D 23500
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTIS 2601
+G YT N GTTS + V + P P PI E TS+ + W PP G +S
Sbjct: 23501 TGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLS 23560
Query: 2602 GYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGIS--LPSEPSE- 2658
GY VE R+ W S + L+ G Y FRV+A+N +GI L SE E
Sbjct: 23561 GYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIEC 23620
Query: 2659 --FVRLPE-------YDAAADGATISW 2676
+R+P +D + DG T++W
Sbjct: 23621 RSSIRIPGPPETLQIFDVSRDGMTLTW 23647
Score = 77.0 bits (188), Expect = 3e-13
Identities = 59/204 (28%), Positives = 79/204 (38%), Gaps = 15/204 (7%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G T+ L V GRP P ITW P+ N+ D + S D + L+ N+ D+G
Sbjct: 13403 GVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLD----IKSTDF-DTFLRCENVNKYDAG 13457
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
Y N G + VKV P P +E S S + W PP G I Y
Sbjct: 13458 KYILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYV 13517
Query: 2605 VEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE--------- 2655
V+ R+ + W T + +L G Y FRV A N +GI P E
Sbjct: 13518 VQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQ 13577
Query: 2656 -PSEFVRLPEYDAAADGATISWKE 2678
P V L + +I WK+
Sbjct: 13578 TPGPVVDLKVRSVSKSSCSIGWKK 13601
Score = 77.0 bits (188), Expect = 3e-13
Identities = 61/216 (28%), Positives = 85/216 (39%), Gaps = 17/216 (7%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G+T +L+ + G+P P + W + + +T +A + S + TL + + + D G
Sbjct: 18417 GETFVLEADIRGKPIPDVVWSKDGKELEET---AARMEIKSTIQ-KTTLVVKDCIRTDGG 18472
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTSVILRWLPPSSTGNCTISGY 2603
Y +N GT S TVKV P P P+ + L W PP G IS Y
Sbjct: 18473 QYILKLSNVGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHY 18532
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE-------- 2655
+E RE W Q + L PG Y FRV A N +GI P E
Sbjct: 18533 IIEKRETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACN 18592
Query: 2656 ---PSEFVRLPEYDA-AADGATISWKENFDSAYTEL 2687
P PE A D ++W D TE+
Sbjct: 18593 PYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEI 18628
Score = 76.3 bits (186), Expect = 4e-13
Identities = 54/187 (28%), Positives = 74/187 (39%), Gaps = 3/187 (1%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLM 2539
+T GDT+ L+ V G+P P + W D++ D S + DS + +L
Sbjct: 11906 LTVKAGDTIRLEAGVRGKPFPEVAWT-KDKDATDLTRSPRVKIDTRADSSKFSLT--KAK 11962
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCT 2599
D G Y ATN G+ ATV V P + S + W PP G C
Sbjct: 11963 RSDGGKYVVTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWDPPEDDGGCE 12022
Query: 2600 ISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF 2659
I Y +E E +W A+ L + L G Y FRV A N G P+E
Sbjct: 12023 IQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTESKPV 12082
Query: 2660 VRLPEYD 2666
+ +YD
Sbjct: 12083 IAKTKYD 12089
Score = 75.9 bits (185), Expect = 6e-13
Identities = 60/199 (30%), Positives = 78/199 (39%), Gaps = 14/199 (7%)
Query: 2476 PLVDVTCLLGDTVIL--------QCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCD 2527
P + V DTVIL + V GRP PT+ W + + T A + D
Sbjct: 15154 PKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGT----AKLEIKIAD 15209
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVI 2586
L + +DSG YT ATN G VKV P P P+A E + +
Sbjct: 15210 FST-NLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEKCV 15268
Query: 2587 LRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASN 2646
L W PP G I Y V+ RE W + T L + L G Y FRV A N
Sbjct: 15269 LSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVN 15328
Query: 2647 PWGISLPSEPSEFVRLPEY 2665
+G+ P E + + Y
Sbjct: 15329 KYGVGEPLESEPVLAVNPY 15347
Score = 75.9 bits (185), Expect = 6e-13
Identities = 53/195 (27%), Positives = 76/195 (38%), Gaps = 21/195 (10%)
Query: 2496 GRPKPTITWKGPDQNILDTDN--SSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATND 2553
GRP P ITW + D YT S D N D+G Y N
Sbjct: 17745 GRPTPEITWSREEGEFTDKVQIEKGVNYTQLSID---------NCDRNDAGKYILKLENS 17795
Query: 2554 HGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQ 2613
G+ S TVKV P P +E S L W PP G + Y ++ RE +
Sbjct: 17796 SGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRK 17855
Query: 2614 IWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE--------- 2664
+ + T +E+L+ G Y FRV A N +G+ +P E + V+ E
Sbjct: 17856 AYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVT 17915
Query: 2665 -YDAAADGATISWKE 2678
D + A++ W++
Sbjct: 17916 LTDVSQTSASLMWEK 17930
Score = 75.5 bits (184), Expect = 7e-13
Identities = 52/180 (28%), Positives = 73/180 (40%), Gaps = 18/180 (10%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNI-----LDTDNSSATYTVSSCDSGEITLKICNLM 2539
G + L + G+P P W Q+I + T + + D G
Sbjct: 23846 GGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRG---------- 23895
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTSVILRWLPPSSTGNC 2598
DSG Y + N G + V+V G P +P P+ + SV + W PP+ G
Sbjct: 23896 --DSGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGA 23953
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
I GY +E RE W + T LV++ L Y FRVSA N +GIS P + E
Sbjct: 23954 DILGYILERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEE 24013
Score = 75.1 bits (183), Expect = 1e-12
Identities = 63/237 (26%), Positives = 100/237 (42%), Gaps = 19/237 (8%)
Query: 2454 PNTSMEILNPNFIQEVAPEFLVPLVD-VTCLLGDTVILQCKVCGRPKPTITWKGPDQNIL 2512
P+T++ I + + E V L++ + G TV + G P PT W D + +
Sbjct: 11188 PDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWT-TDGSEI 11246
Query: 2513 DTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAP 2572
TD YTV + D+ L I N + +D+G Y +N G+ + + + V VP P
Sbjct: 11247 KTDEH---YTVET-DNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPP 11302
Query: 2573 NRPI-AQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIED 2631
PI + + + + W PP G + Y VE ++ W + + T L I
Sbjct: 11303 TGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPH 11362
Query: 2632 LSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEY------------DAAADGATISW 2676
L GC Y FRV A N G+ P + + V ++ D + AT+SW
Sbjct: 11363 LQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSW 11419
Score = 74.3 bits (181), Expect = 2e-12
Identities = 62/214 (28%), Positives = 86/214 (40%), Gaps = 27/214 (12%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITW--KGPD---QNILDTDNSSATYTVSSCDSGEITLK 2534
VT G ++ L V GRP P ITW +G D + I+DT S + V +
Sbjct: 23151 VTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNR------ 23204
Query: 2535 ICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSS 2594
D+G YT A N G S + VKV P +E S SV + W P+
Sbjct: 23205 ------YDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTI 23258
Query: 2595 TGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPS 2654
G ++ Y VE RE + ++ T I L G Y FRV N +GI P
Sbjct: 23259 DGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPC 23318
Query: 2655 EPSEFV----------RLPEYDAAADGATISWKE 2678
E S+ V +L D T++W++
Sbjct: 23319 ETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEK 23352
Score = 73.9 bits (180), Expect = 2e-12
Identities = 61/206 (29%), Positives = 83/206 (40%), Gaps = 20/206 (9%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G+T L+ V G+P PTI W D+ I SA + + D + + + + + D G
Sbjct: 17335 GETFRLEADVHGKPLPTIEWLRGDKEI----EESARCEIKNTDFKALLI-VKDAIRIDGG 17389
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTS--VILRWLPPSSTGNCTISG 2602
Y A+N G+ S VKV P P P+ Q TS L W PP G IS
Sbjct: 17390 QYILRASNVAGSKSFPVNVKVLDRPGPPEGPV-QVTGVTSEKCSLTWSPPLQDGGSDISH 17448
Query: 2603 YTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE------- 2655
Y VE RE W + + L + L G Y FR+ A N +G+ P E
Sbjct: 17449 YVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMK 17508
Query: 2656 -----PSEFVRLPEYDAAADGATISW 2676
P L + A D T+ W
Sbjct: 17509 NPFVLPGPPKSLEVTNIAKDSMTVCW 17534
Score = 73.6 bits (179), Expect = 3e-12
Identities = 61/271 (22%), Positives = 100/271 (36%), Gaps = 46/271 (16%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNS-------------------------SA 2519
GD + L + G P PTITW D+N++ + +
Sbjct: 8389 GDEIALDASISGSPYPTITWI-KDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQ 8447
Query: 2520 TYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQE 2579
++ + GE L++ + + D G+Y NDHG TV V P P + ++
Sbjct: 8448 RLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPINFVFED 8507
Query: 2580 RSCTSVILRWLPPSSTGNCTISGYTVEYRE--EGSQIWQQSVASTLDTYLVIEDLSPGCP 2637
TSV+ +W PP G I YT+E ++ + W ++ + L G
Sbjct: 8508 IRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKE 8567
Query: 2638 YQFRVSASNPWGISLPSEPSEFVRLPEY------------DAAADGATISWKENFDSA-- 2683
Y FRV A N +G P V + D ++ + W E D+
Sbjct: 8568 YLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNGSP 8627
Query: 2684 ----YTELNEIGRGRFSIVKKCIHKATRKDV 2710
+ E E+ +S V K + A + +V
Sbjct: 8628 ILGYWLEKREVNSTHWSRVNKSLLNALKANV 8658
Score = 72.8 bits (177), Expect = 5e-12
Identities = 64/221 (28%), Positives = 95/221 (42%), Gaps = 21/221 (9%)
Query: 2444 SEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTC-------LLGDTVILQCKVCG 2496
S E++ DP+ EIL P + F+ P +D++ ++ + + + G
Sbjct: 7062 SAENKAGVSDPS---EILGPLTADDA---FVEPTMDLSAFKDGLEVIVPNPITILVPSTG 7115
Query: 2497 RPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT 2556
P+PT TW D+ +L+T + T+S+ L I D GIYT N T
Sbjct: 7116 YPRPTATWCFGDK-VLETGDRVKMKTLSAYAE----LVISPSERSDKGIYTLKLENRVKT 7170
Query: 2557 TSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQ 2616
S V V P+AP + + SV L W PP G ++GY VE RE + W
Sbjct: 7171 ISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWT 7230
Query: 2617 QSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPS 2657
+ + D + DL G Y F+V A N G P EP+
Sbjct: 7231 KVMDFVTDLEFTVPDLVQGKEYLFKVCARNKCG---PGEPA 7268
Score = 72.8 bits (177), Expect = 5e-12
Identities = 54/180 (30%), Positives = 74/180 (41%), Gaps = 12/180 (6%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G++ + + G+P PTI W DQ + +T A + S D +L + + + DSG
Sbjct: 16253 GESFKVDADIYGKPIPTIQWIKGDQELSNT----ARLEIKSTDFAT-SLSVKDAVRVDSG 16307
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA----QERSCTSVILRWLPPSSTGNCTI 2600
Y A N G S + VKV P P P+ CT L W PP G I
Sbjct: 16308 NYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCT---LAWKPPLQDGGSDI 16364
Query: 2601 SGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
Y VE RE +W A+ + L G Y FR+ A N +G+ P E V
Sbjct: 16365 INYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVV 16424
Score = 72.0 bits (175), Expect = 8e-12
Identities = 44/168 (26%), Positives = 74/168 (44%), Gaps = 6/168 (3%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G + + + G+P P +T + T + T + +T+ + + D+G
Sbjct: 20186 GSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAEN-----LTINLKESVTADAG 20240
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTISGY 2603
Y A N GTT + V P P P+ + + SV L+W PP G ++ Y
Sbjct: 20241 RYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNY 20300
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGIS 2651
+ RE + +W + A+ T + + L+ G YQFR+ A N +GIS
Sbjct: 20301 ILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAENRFGIS 20348
Score = 71.6 bits (174), Expect = 1e-11
Identities = 63/231 (27%), Positives = 91/231 (39%), Gaps = 23/231 (9%)
Query: 2459 EILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSS 2518
EIL P I A + +V C + L V GRP P +TW+ + DN
Sbjct: 12294 EILEPPEIDLDASMRKLVIVRAGC----PIRLFAIVRGRPAPKVTWRK-----VGIDNVV 12344
Query: 2519 ATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQ 2578
V D+ L I N DSG Y+ N G + V+V P +
Sbjct: 12345 RKGQVDLVDTMAF-LVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVS 12403
Query: 2579 ERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPY 2638
+ + TS + W PP + G ++ Y VE RE + W T + +L PG Y
Sbjct: 12404 DVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEY 12463
Query: 2639 QFRVSASNPWGISLP-------------SEPSEFVRLPEYDAAADGATISW 2676
FRV+A N +G +P SEP +L + + AT++W
Sbjct: 12464 YFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAW 12514
Score = 71.6 bits (174), Expect = 1e-11
Identities = 48/177 (27%), Positives = 76/177 (42%), Gaps = 6/177 (3%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G +V L+ + G+P PTI W D+ + ++ ++ D I +K + + +SG
Sbjct: 20582 GTSVKLRAGISGKPAPTIEWYKDDKEL---QTNALVCVENTTDLASILIKDADRL--NSG 20636
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTSVILRWLPPSSTGNCTISGY 2603
Y N G+ S + V++ P P PI + + + L W PP+ G I+ Y
Sbjct: 20637 CYELKLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHY 20696
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
VE RE +W + + + G Y FRV A N +GI P E V
Sbjct: 20697 IVEKRETSRVVWSMVSEHLEECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVV 20753
Score = 71.2 bits (173), Expect = 1e-11
Identities = 67/221 (30%), Positives = 97/221 (43%), Gaps = 29/221 (13%)
Query: 2364 PASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHTLR---MRKRAE------- 2413
P ++H A + GS +A L K +A SS I KS T++ R RAE
Sbjct: 778 PKTEHGYEAS--IAGSAIATLQKELSATSSAQKITKSVKAPTVKPSETRVRAEPTPLPQF 835
Query: 2414 ----VENTGKNEATGPRKPKDILGNKVSVKETNSSEES----ECDDLDPNTSMEILNPNF 2465
+T K+EA G K++ VS+ T EE + + + P
Sbjct: 836 PFADTPDTYKSEA-GVEVKKEV---GVSITGTTVREERFEVLHGREAKVTETARVPAPVE 891
Query: 2466 IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSS 2525
I P + L +VT + G++V L+C + G P PT+TW D I + + T+
Sbjct: 892 IPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF---- 947
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
SG L I +DSG +TC A N+ GT STS + VQ
Sbjct: 948 -QSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 987
Score = 70.9 bits (172), Expect = 2e-11
Identities = 50/166 (30%), Positives = 69/166 (41%), Gaps = 7/166 (4%)
Query: 2484 LGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDS 2543
+GDT+ L + G P P +TWK D++ T S L+I N +D
Sbjct: 10927 VGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSK-------LEIRNAAHEDG 10979
Query: 2544 GIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
GIY+ N G+ + S V V P P E S L W P G I+ Y
Sbjct: 10980 GIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNY 11039
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG 2649
VE R+ S W A++ + L+ G Y FRV+A N +G
Sbjct: 11040 VVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYG 11085
Score = 70.5 bits (171), Expect = 2e-11
Identities = 61/253 (24%), Positives = 104/253 (41%), Gaps = 24/253 (9%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G + + V G+P PT+TW ++ L + + T +SS ++ I N G
Sbjct: 10234 GGVIRIIAYVSGKPPPTVTWN-MNERTLPQEATIETTAISS------SMVIKNCQRSHQG 10286
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRP-IAQERSCTSVILRWLPPSSTGNCTISGY 2603
+Y+ +A N+ G + V V VP P +A + S L W P G I+ Y
Sbjct: 10287 VYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNY 10346
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF---- 2659
+E RE + W + ++ L G Y FR++A N G+ E SE
Sbjct: 10347 VIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIR 10406
Query: 2660 --VRLPE-------YDAAADGATISWK-ENFDSAYTELNEIGRGRFSIVKKCIHKATRKD 2709
+ +PE + + T++W +D +N + R +K HK T +
Sbjct: 10407 EPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEK-FHKVTNDN 10465
Query: 2710 -VAVKFVSKKMKK 2721
++ K+ K +K+
Sbjct: 10466 LLSRKYTVKGLKE 10478
Score = 68.9 bits (167), Expect = 7e-11
Identities = 63/245 (25%), Positives = 94/245 (38%), Gaps = 36/245 (14%)
Query: 2429 KDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLL---G 2485
K++ + VK N + ESE D T+ EI + +E PE + + CL+ G
Sbjct: 9467 KELRKYRFRVKAVNEAGESEPSD----TTGEIPATDIQEE--PEVFIDIGAQDCLVCKAG 9520
Query: 2486 DTVILQCKVCGRPKPTITWKG---------------PDQNILDTDNSSATYTVSSCDSGE 2530
+ + + GRP P +W+ P+ L+T +S+ + C
Sbjct: 9521 SQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSH 9580
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWL 2590
+G Y+ A N G + + VKV VP P + + S L W
Sbjct: 9581 ------------TGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWK 9628
Query: 2591 PPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI 2650
P G I GY +E R + W + T V+ DL Y FRV A N +GI
Sbjct: 9629 MPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGI 9688
Query: 2651 SLPSE 2655
P E
Sbjct: 9689 GPPVE 9693
Score = 68.6 bits (166), Expect = 9e-11
Identities = 56/181 (30%), Positives = 83/181 (45%), Gaps = 10/181 (5%)
Query: 2484 LGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQD- 2542
+G T+ L GRP P +TW + + +++N + T L + N+ +
Sbjct: 24337 VGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTH-----LVMKNVQRKTH 24391
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSC-TSVILRWLPPSSTGNCTIS 2601
+G Y +N GT V++Q P P PI E S ++ W PP+ G I+
Sbjct: 24392 AGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWIT 24451
Query: 2602 GYTVEYRE--EGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF 2659
Y VE E EG++ WQ ++ T I +L+ Y FRVSA N +GIS P E S
Sbjct: 24452 NYVVEKCEAKEGAE-WQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSV 24510
Query: 2660 V 2660
V
Sbjct: 24511 V 24511
Score = 68.2 bits (165), Expect = 1e-10
Identities = 44/153 (28%), Positives = 70/153 (45%), Gaps = 6/153 (3%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGV-----P 2569
+ S ++T S + + K+ L+P + I+ +A N +G + V P
Sbjct: 18538 ETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPP 18597
Query: 2570 AAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLV 2628
P+ P + S+++ W P G I GY +E R++ W + TL D L
Sbjct: 18598 GPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLR 18657
Query: 2629 IEDLSPGCPYQFRVSASNPWGISLPSEPSEFVR 2661
+ L+ G Y+FRV+A N G+ PSEPS F R
Sbjct: 18658 VTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYR 18690
Score = 67.8 bits (164), Expect = 2e-10
Identities = 67/259 (25%), Positives = 106/259 (40%), Gaps = 29/259 (11%)
Query: 2435 KVSVKETNSSEESECDDLDPNTSMEILNPNFIQ-EVAPEFLVPLVDVTCLLGDTVILQCK 2493
K+ V N++ E + P T E P ++ +V+ + + + + G T+ +
Sbjct: 8768 KLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQI-----MAGKTLRIPAV 8822
Query: 2494 VCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATND 2553
V GRP PT W ++ LD D V + L I + + +D G Y ATN
Sbjct: 8823 VTGRPVPTKVWT-KEEGELDKDR-----VVIDNVGTKSELIIKDALRKDHGRYVITATNS 8876
Query: 2554 HGTTSTSATVKVQGV--PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEG 2611
G+ +A V+V V P +P+ R +L W P G I+G+ +E ++
Sbjct: 8877 CGSKFAAARVEVFDVPGPVLDLKPVVTNRK--MCLLNWSDPEDDGGSEITGFIIERKDAK 8934
Query: 2612 SQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE------------PSEF 2659
W+Q + T + I L G Y+FRV A N +G P E P+
Sbjct: 8935 MHTWRQPI-ETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSP 8993
Query: 2660 VRLPEYDAAADGATISWKE 2678
RL + T+ WKE
Sbjct: 8994 ERLTYTERTKSTITLDWKE 9012
Score = 67.8 bits (164), Expect = 2e-10
Identities = 51/205 (24%), Positives = 85/205 (41%), Gaps = 30/205 (14%)
Query: 2487 TVILQCKVCGRPKP---------------TITWKGPDQN---------ILDTDNSSATYT 2522
+V + CKV +P P +++W P ++ + + S +T
Sbjct: 19567 SVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWT 19626
Query: 2523 VSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG-----VPAAPNRPIA 2577
+ + + K+ L+ + I+ N +G +V ++ VP+ P
Sbjct: 19627 ICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEI 19686
Query: 2578 QERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGC 2636
+ S+ L W P S G ISGY +E RE+ S W + + D + L GC
Sbjct: 19687 TSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGC 19746
Query: 2637 PYQFRVSASNPWGISLPSEPSEFVR 2661
Y++RV A N G+SLPSE S +R
Sbjct: 19747 EYEYRVYAENAAGLSLPSETSPLIR 19771
Score = 67.4 bits (163), Expect = 2e-10
Identities = 52/181 (28%), Positives = 69/181 (38%), Gaps = 5/181 (2%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLM 2539
VT G ++L V G+P+P I W D+ + + S YT + +K C+
Sbjct: 22752 VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATA---VIKFCDR- 22807
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCT 2599
DSG YT N GT + S VKV P + + L W P G
Sbjct: 22808 -SDSGKYTLTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAE 22866
Query: 2600 ISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF 2659
I+ Y VE RE W V+ L Y FRV A N +G +P E
Sbjct: 22867 ITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPI 22926
Query: 2660 V 2660
V
Sbjct: 22927 V 22927
Score = 66.6 bits (161), Expect = 3e-10
Identities = 56/211 (26%), Positives = 88/211 (41%), Gaps = 10/211 (4%)
Query: 2467 QEVAPEFLVPLVDVTCLL---GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTV 2523
+E+AP+F + L+ G ++ + + GRP P +TW + N+ + N T +
Sbjct: 14465 REMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESF 14524
Query: 2524 SSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCT 2583
+ + + CN D+G + N G S V+V P + +
Sbjct: 14525 TL-----LIIPECNRY--DTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKD 14577
Query: 2584 SVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVS 2643
SV L W P G I+ Y VE RE + + + + LS GC Y FRV
Sbjct: 14578 SVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVM 14637
Query: 2644 ASNPWGISLPSEPSEFVRLPEYDAAADGATI 2674
A N +GI P+E +E V+ E + D I
Sbjct: 14638 AENEYGIGEPTETTEPVKASEAPSPPDSLNI 14668
Score = 65.9 bits (159), Expect = 6e-10
Identities = 55/212 (25%), Positives = 90/212 (42%), Gaps = 18/212 (8%)
Query: 2479 DVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNL 2538
D+ + G+ + + P PT++W + + +D + D L++
Sbjct: 8090 DIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKN-----DHISAHLEVPKS 8144
Query: 2539 MPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNC 2598
+ D+GIYT N G+ + S VKV G+P A + + +S L W PP G
Sbjct: 8145 VRADAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGT 8204
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG----ISL-- 2652
I Y +E RE G + + ++ ++DL P Y FRV A N G I L
Sbjct: 8205 PILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKN 8264
Query: 2653 ------PSEPSE-FVRLPEYDAAADGATISWK 2677
P +P + V + ++ A+ TI+WK
Sbjct: 8265 PVIAQDPKQPPDPPVDVEVHNPTAEAMTITWK 8296
Score = 65.5 bits (158), Expect = 8e-10
Identities = 46/138 (33%), Positives = 68/138 (49%), Gaps = 8/138 (5%)
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTS--TSATVKVQG---VPAAPNRPIAQERSC 2582
S + T K+ L+ I+ A N +G + S ++K + VP AP++PI E +
Sbjct: 10661 SAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTK 10720
Query: 2583 TSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLV--IEDLSPGCPYQF 2640
S ++ W P G I+ Y +E RE S+ W + + Y + DL GC Y+F
Sbjct: 10721 DSALVTWNKPHDGGK-PITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEF 10779
Query: 2641 RVSASNPWGISLPSEPSE 2658
RVSA N GI PS PS+
Sbjct: 10780 RVSAENEIGIGDPSPPSK 10797
Score = 65.5 bits (158), Expect = 8e-10
Identities = 46/173 (26%), Positives = 76/173 (43%), Gaps = 15/173 (8%)
Query: 2501 TITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIAT 2551
T+ W+ P + +L + S+A +T S +K+ L + + A
Sbjct: 20283 TLKWEPPKYDGGSQVTNYILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAE 20342
Query: 2552 NDHGTT----STSATVKVQ-GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVE 2606
N G + S TVK+ P P+ P + S+ + W P S G + GY +E
Sbjct: 20343 NRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSAVVGYHLE 20402
Query: 2607 YREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
++ S +WQ++ + T+ + +S G Y+FRV A N G+ PS PSE
Sbjct: 20403 MKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSHPSE 20455
Score = 65.1 bits (157), Expect = 1e-09
Identities = 46/171 (26%), Positives = 74/171 (43%), Gaps = 5/171 (2%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILD--TDNSSATYTVSSCDSGEITLKICNLMPQD 2542
G+ V + V G P P I W ++ +++ TD T S + L I + +D
Sbjct: 9108 GEPVHIPADVTGLPMPKIEWS-KNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVRED 9166
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISG 2602
G YT A+N G+ + V+V P+ P + S L W P G I+
Sbjct: 9167 KGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAPLDNGGSEITH 9226
Query: 2603 YTVEYREEGSQ--IWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGIS 2651
Y ++ R+ + W++ + ++ I L P Y+FRV A N +GIS
Sbjct: 9227 YVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGIS 9277
Score = 64.7 bits (156), Expect = 1e-09
Identities = 53/183 (28%), Positives = 75/183 (40%), Gaps = 30/183 (16%)
Query: 2502 ITWKGPDQNILDTDNSSAT-YTVSSCDSG-------EIT-------LKICNLMPQDSGIY 2546
+TW P LD S T Y + D+ E+T I L+P +
Sbjct: 9211 LTWDAP----LDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEF 9266
Query: 2547 TCIATNDHGTTSTSATVKV-----QGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTIS 2601
A N +G + + KV +P P +P R+ S+++ W PP G I+
Sbjct: 9267 RVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPIT 9326
Query: 2602 GYTVEYREEGSQIWQQSVASTL------DTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
GY +E REEGS W + + + + L G YQFR A N GI PSE
Sbjct: 9327 GYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSE 9386
Query: 2656 PSE 2658
PS+
Sbjct: 9387 PSD 9389
Score = 64.7 bits (156), Expect = 1e-09
Identities = 31/91 (34%), Positives = 49/91 (53%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYL 2627
+P+ P++P + T++ + W+ P G I+GYTVEY++ W+ S+ S T
Sbjct: 19778 LPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEY 19837
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
I L+ G Y FRV + N G S PS+ S+
Sbjct: 19838 TISGLTTGAEYVFRVKSVNKVGASDPSDSSD 19868
Score = 64.3 bits (155), Expect = 2e-09
Identities = 36/108 (33%), Positives = 54/108 (50%), Gaps = 1/108 (0%)
Query: 2558 STSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ 2617
S AT + P P P + + +S L W PP G ++GY VEY+EEG + W++
Sbjct: 10105 SDPATARDPIAPPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEK 10164
Query: 2618 SVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
+ T LV+ L G Y+FRV A N GI P E ++ + + +
Sbjct: 10165 GKDKEVRGTKLVVTGLKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKD 10212
Score = 64.3 bits (155), Expect = 2e-09
Identities = 46/172 (26%), Positives = 72/172 (41%), Gaps = 6/172 (3%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G+ + + + GRP P I+W ++ ++ + + T +S+ + +T+K C + +D+G
Sbjct: 19499 GEVLKINADIAGRPLPVISWA---KDGIEIEERARTEIISTDNHTLLTVKDC--IRRDTG 19553
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPI-AQERSCTSVILRWLPPSSTGNCTISGY 2603
Y N GT S + KV P P P+ + L W P G I Y
Sbjct: 19554 QYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYY 19613
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
VE RE W T + L G Y FRV+ N +G+ P E
Sbjct: 19614 IVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLE 19665
Score = 63.5 bits (153), Expect = 3e-09
Identities = 68/267 (25%), Positives = 107/267 (40%), Gaps = 32/267 (11%)
Query: 2466 IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSS 2525
I E PE+ L+ + G+++ ++ V GRP P +TW I N T +
Sbjct: 21652 IVEFGPEYFDGLIIKS---GESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVL-- 21706
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTS 2584
G +L + + G+YT A N G+ VKVQ P PI +
Sbjct: 21707 ---GSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEK 21763
Query: 2585 VILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVS 2643
+ L W P + G I+ Y +E RE W +Y I+ L G YQFRVS
Sbjct: 21764 MTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIK-LINGNEYQFRVS 21822
Query: 2644 ASNPWGISLPSEPSEFVRLPEY------------DAAADGATISWKENFDSAYTELNEIG 2691
A N +G+ P + V +Y + + T++W +E+ +
Sbjct: 21823 AVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQY- 21881
Query: 2692 RGRFSIVKKCIHKATRKDVAVKFVSKK 2718
I+++ K+TR VK +SK+
Sbjct: 21882 -----ILERREKKSTR---WVKVISKR 21900
Score = 63.5 bits (153), Expect = 3e-09
Identities = 49/185 (26%), Positives = 78/185 (42%), Gaps = 18/185 (9%)
Query: 2499 KPTITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
K T+ W P ++ + + S + + + ++ + L+ + I+
Sbjct: 22851 KCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVR 22910
Query: 2550 ATNDHGTTSTSATVKVQG-----VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
A N +G + + +P+ P P +I++W P S G IS Y
Sbjct: 22911 AVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYL 22970
Query: 2605 VEYREEGSQIWQQSVASTL--DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV-- 2660
V+ RE+ S W + + DT L + L GC YQFRV+A N G S PSE S F+
Sbjct: 22971 VDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISC 23030
Query: 2661 RLPEY 2665
R P Y
Sbjct: 23031 REPSY 23035
Score = 62.8 bits (151), Expect = 5e-09
Identities = 51/181 (28%), Positives = 79/181 (43%), Gaps = 15/181 (8%)
Query: 2499 KPTITWKGPDQN--------ILDT-DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
K T+TW P ++ IL+ + S +TV S D L+ + I+
Sbjct: 14183 KATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVS 14242
Query: 2550 ATNDHGTTSTSATVKVQ-----GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
A N +G + V+ G P P +P + + + W P G I+GY
Sbjct: 14243 AVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYH 14302
Query: 2605 VEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLP 2663
VE RE+ S W +++ + + D + L G Y+FRVSA N GI PSE S+ V +
Sbjct: 14303 VERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMK 14362
Query: 2664 E 2664
+
Sbjct: 14363 D 14363
Score = 62.4 bits (150), Expect = 7e-09
Identities = 62/234 (26%), Positives = 94/234 (40%), Gaps = 25/234 (10%)
Query: 2426 RKPKDILGN--KVSVKETNSSEESECDDLDPNT-SMEILNPNFIQEVAPEFLVPLVDVTC 2482
R P I GN + +K N E E +L + + +IL+P ++ +DVTC
Sbjct: 11560 RVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVE----------LDVTC 11609
Query: 2483 L------LGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKIC 2536
+G T+ + +V GRP+P ITW + ++ D + L+I
Sbjct: 11610 RDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQ-----DLPRVELQIK 11664
Query: 2537 NLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTG 2596
+ D G Y A N G SA V V P + + + W P G
Sbjct: 11665 EAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVTKENCTISWENPLDNG 11724
Query: 2597 NCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI 2650
I+ + VEYR+ + W VAS + L+ +L Y FRV A N G+
Sbjct: 11725 GSEITNFIVEYRKPNQKGW-SIVASDVTKRLIKANLLANNEYYFRVCAENKVGV 11777
Score = 62.4 bits (150), Expect = 7e-09
Identities = 51/200 (25%), Positives = 81/200 (40%), Gaps = 25/200 (12%)
Query: 2502 ITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATN 2552
++W P+ N I + S + + T K+ NL+ + A N
Sbjct: 21371 LSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAEN 21430
Query: 2553 DHGTT----STSATVKVQ-GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEY 2607
+G + S+ K Q +P P +P+ + + L W P G ++G+ VE
Sbjct: 21431 RYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEK 21490
Query: 2608 REEGSQIWQQSVASTLD-TYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV------ 2660
+E S +WQ+ S + L G YQFRV A N G+S PS+PS+F
Sbjct: 21491 KERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPV 21550
Query: 2661 ---RLPEY-DAAADGATISW 2676
P+Y D + T+ W
Sbjct: 21551 DPPGTPDYIDVTRETITLKW 21570
Score = 62.4 bits (150), Expect = 7e-09
Identities = 38/111 (34%), Positives = 56/111 (50%), Gaps = 6/111 (5%)
Query: 2470 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG 2529
AP + DVT LG+ L C++ GRP P I W + ++ S Y +SS D
Sbjct: 24227 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ----SRKYKMSS-DGR 24281
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPA-APNRPIAQE 2579
TL + +D G+YTCIATN+ G TS+ + +Q P P P+ ++
Sbjct: 24282 THTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEK 24332
Score = 62.0 bits (149), Expect = 8e-09
Identities = 45/150 (30%), Positives = 67/150 (44%), Gaps = 6/150 (4%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTS---TSATVKVQG--VP 2569
D S+ T+ + S T+K C L + A N +G ++ + TV VP
Sbjct: 15977 DTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVP 16036
Query: 2570 AAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLV 2628
P P+ S S+ ++W P S G + GY +E +E S +W + + + T
Sbjct: 16037 GPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFK 16096
Query: 2629 IEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
L G Y+FRVSA N GI PS+ SE
Sbjct: 16097 TTGLEEGVEYEFRVSAENIVGIGKPSKVSE 16126
Score = 61.6 bits (148), Expect = 1e-08
Identities = 36/104 (34%), Positives = 51/104 (49%), Gaps = 3/104 (2%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLV 2628
PA P R + S +S +L WL P G I+GY +E R++GS W ++ T
Sbjct: 22241 PAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEA-GHTKQLTFT 22299
Query: 2629 IEDLSPGCPYQFRVSASNPWGISLPSE--PSEFVRLPEYDAAAD 2670
+E L Y+FRV A N G S P E S ++ P+ + AD
Sbjct: 22300 VERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTAD 22343
Score = 61.2 bits (147), Expect = 1e-08
Identities = 42/143 (29%), Positives = 64/143 (44%), Gaps = 7/143 (4%)
Query: 2520 TYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ------GVPAAPN 2573
T++ + + + + + NL+P + + A N++G + K P P
Sbjct: 12439 TWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPR 12498
Query: 2574 RPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLVIEDL 2632
+ E + S L WLPP G I GY YREE + + S + D LV+ L
Sbjct: 12499 KLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGL 12558
Query: 2633 SPGCPYQFRVSASNPWGISLPSE 2655
G Y+FRV+A N G+SLP E
Sbjct: 12559 KEGKKYKFRVAARNAVGVSLPRE 12581
Score = 61.2 bits (147), Expect = 1e-08
Identities = 47/189 (24%), Positives = 82/189 (43%), Gaps = 9/189 (4%)
Query: 2520 TYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPI 2576
+Y+ ++ + T K+ L + +A N++G T T+ VK P+ P+
Sbjct: 14608 SYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLN 14667
Query: 2577 AQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGC 2636
+ + ++V L W P G I+GY +E + +GS W + + V+ +L+ G
Sbjct: 14668 IMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTH-ITTVKGLECVVRNLTEGE 14726
Query: 2637 PYQFRVSASNPWGISLPSEP-----SEFVRLPEYDAAADGATISWKENFDSAYTELNEIG 2691
Y F+V A N G S P E E LPE D + + D+ E+ +G
Sbjct: 14727 EYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLG 14786
Query: 2692 RGRFSIVKK 2700
R + ++ K
Sbjct: 14787 RPKPTVTWK 14795
Score = 61.2 bits (147), Expect = 1e-08
Identities = 41/135 (30%), Positives = 60/135 (44%), Gaps = 6/135 (4%)
Query: 2533 LKICNLMPQDSGIYTCIATNDHGT-----TSTSATVKVQGVPAAPNRPIAQERSCTSVIL 2587
LK+ L+ + I+ +A N +G + V G P P P + S+++
Sbjct: 15309 LKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVV 15368
Query: 2588 RWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASN 2646
W P S G I Y VE R++ Q W + TL D + L+ G Y+FR+ A N
Sbjct: 15369 CWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAEN 15428
Query: 2647 PWGISLPSEPSEFVR 2661
GIS PS S F +
Sbjct: 15429 AAGISAPSPTSPFYK 15443
Score = 60.8 bits (146), Expect = 2e-08
Identities = 53/183 (28%), Positives = 76/183 (41%), Gaps = 19/183 (10%)
Query: 2490 LQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG------------EITLKICN 2537
L+ K + T+TW P +LD + Y V +S + + K+
Sbjct: 15653 LKVKEVTKTSVTLTWDPP---LLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQ 15709
Query: 2538 LMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSS 2594
L S + +A N++G T+ +VK P P + + + SV L W P
Sbjct: 15710 LQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKPEH 15769
Query: 2595 TGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPS 2654
G I GY VE + +GS W + A+ T I L G Y FRVSA N GIS P
Sbjct: 15770 DGGSRILGYIVEMQTKGSDKW-ATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPR 15828
Query: 2655 EPS 2657
+ S
Sbjct: 15829 QLS 15831
Score = 60.1 bits (144), Expect = 3e-08
Identities = 47/176 (26%), Positives = 76/176 (43%), Gaps = 15/176 (8%)
Query: 2499 KPTITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
K T+ WK P Q+ + + S +TV + ++ K+ L+ + + +
Sbjct: 16348 KCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRIM 16407
Query: 2550 ATNDHGTTSTSATVKVQG-----VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
A N +G + V VP AP P + S+I+ W P+S G I GY
Sbjct: 16408 AVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYV 16467
Query: 2605 VEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF 2659
+E R++ W + + + L + L Y+FRVSA N G+S PS PS +
Sbjct: 16468 LEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAY 16523
Score = 60.1 bits (144), Expect = 3e-08
Identities = 44/150 (29%), Positives = 68/150 (45%), Gaps = 6/150 (4%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTST--SATVKVQ---GVP 2569
D ++ T+ + S T+KI L + A N +G ++ S V VQ P
Sbjct: 18141 DTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEP 18200
Query: 2570 AAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLV 2628
P P S ++++W P + G I GY +E +E+ S +W + + + DT
Sbjct: 18201 GPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFK 18260
Query: 2629 IEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
L G Y+F+VSA N GI PS+ SE
Sbjct: 18261 TTGLDEGLEYEFKVSAENIVGIGKPSKVSE 18290
Score = 59.7 bits (143), Expect = 4e-08
Identities = 42/145 (28%), Positives = 68/145 (46%), Gaps = 6/145 (4%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAA 2571
+ + Y + + + T +I NL S + +A+N++G T+ VKV P
Sbjct: 18934 ETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLP 18993
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P R + + + ++W P S G I+GY VE + +GS+ W + TL+ I
Sbjct: 18994 PGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEA--TIS 19051
Query: 2631 DLSPGCPYQFRVSASNPWGISLPSE 2655
L+ G Y FRV+A N G S P +
Sbjct: 19052 GLTAGEEYVFRVAAVNEKGRSDPRQ 19076
Score = 59.3 bits (142), Expect = 6e-08
Identities = 37/113 (32%), Positives = 51/113 (45%), Gaps = 5/113 (4%)
Query: 2558 STSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ 2617
ST ATV P P ++R+ S+ L W PP + G I GY VE GS W
Sbjct: 7277 STPATV-----PDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVA 7331
Query: 2618 SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAAD 2670
+T + + L G Y +RV A N G S PS P+E ++ + A +
Sbjct: 7332 CGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPE 7384
Score = 58.2 bits (139), Expect = 1e-07
Identities = 49/177 (27%), Positives = 65/177 (36%), Gaps = 22/177 (12%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTC------------ 2548
T+TW PD D + Y V D CN MP Y
Sbjct: 7595 TLTWCEPDD---DGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFR 7651
Query: 2549 -IATNDHGTTSTSATVKVQGV------PAAPNRPIAQERSCTSVILRWLPPSSTGNCTIS 2601
+A N G S + + + P P +P ++ TSV L W P G I
Sbjct: 7652 VLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIE 7711
Query: 2602 GYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
Y +E + G+ W + T ++ L G Y FRV A N G S PSEPS+
Sbjct: 7712 SYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSD 7768
Score = 58.2 bits (139), Expect = 1e-07
Identities = 33/92 (35%), Positives = 48/92 (52%), Gaps = 1/92 (1%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTY- 2626
VP AP P + SV L W P TG I+GY +E++E S +W+++ + +
Sbjct: 13870 VPDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRD 13929
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
+ L+ G Y+FRV A N G+ PS PSE
Sbjct: 13930 FKVTGLTEGLEYEFRVMAINLAGVGKPSLPSE 13961
Score = 58.2 bits (139), Expect = 1e-07
Identities = 42/173 (24%), Positives = 75/173 (43%), Gaps = 15/173 (8%)
Query: 2501 TITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIAT 2551
TI+W P+ + + + +S T+ + S ++KI L + A
Sbjct: 19200 TISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAE 19259
Query: 2552 NDHGTTSTSATVKVQGV-----PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVE 2606
N +G +S S + V P P P + +++++ W P + G + GY +E
Sbjct: 19260 NRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLE 19319
Query: 2607 YREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
Y+E S +W ++ + DT + + L G Y++RV A N GI S+ E
Sbjct: 19320 YKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCE 19372
Score = 57.8 bits (138), Expect = 2e-07
Identities = 50/205 (24%), Positives = 83/205 (40%), Gaps = 37/205 (18%)
Query: 2490 LQCKVCGRPKP---------------TITWKGPDQN---------ILDTDNSSATYTVSS 2525
++ V GRP P T++W P + I + + T+ S
Sbjct: 9904 MRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVS 9963
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGT-----TSTSATVKVQGVPAAPNRPIAQER 2580
+ E T I L+ ++ +A N +G + + VP AP++P
Sbjct: 9964 SEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSV 10023
Query: 2581 SCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-----SVASTLDTYLVIEDLSPG 2635
+ S+ + W P G ++GY +E ++ S+ W++ A TL + L G
Sbjct: 10024 TRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEG 10083
Query: 2636 CPYQFRVSASNPWGI---SLPSEPS 2657
YQFRV A N G+ SLPS+P+
Sbjct: 10084 SDYQFRVYAINAAGVGPASLPSDPA 10108
Score = 57.8 bits (138), Expect = 2e-07
Identities = 51/178 (28%), Positives = 78/178 (43%), Gaps = 17/178 (9%)
Query: 2490 LQCKVCGRPKPTITWKGP---------DQNILDTDNSSATYTVSSCDSGEITLKICNLMP 2540
LQ K R T+ W P + I D + T++V S + K+ +L
Sbjct: 21067 LQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSE 21126
Query: 2541 QDSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQERSC-TSVILRWLPPSSTG 2596
+ + +A N+ G T+ VK VPA P R ++ + S TSVIL W P G
Sbjct: 21127 KTPFFFRVLAENEIGIGEPCETTEPVKAAEVPA-PIRDLSMKDSTKTSVILSWTKPDFDG 21185
Query: 2597 NCTISGYTVEYREEGSQIWQQS-VASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP 2653
I+ Y VE + +G Q W + ++ T + + + L +FRV A N G+S P
Sbjct: 21186 GSVITEYVVERKGKGEQTWSHAGISKTCE--IEVSQLKEQSVLEFRVFAKNEKGLSDP 21241
Score = 57.4 bits (137), Expect = 2e-07
Identities = 69/297 (23%), Positives = 112/297 (37%), Gaps = 36/297 (12%)
Query: 2390 AESSDGSIKKSCSWHTL-----RMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSS 2444
++SSD I K L MRK V+ T P + + + S +T+
Sbjct: 19864 SDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLR 19923
Query: 2445 EESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKP---- 2500
+ D D TS+ I N N + + ++ + + +V T+++ KV P P
Sbjct: 19924 TRAYVDTTDSRTSLTIENAN--RNDSGKYTLTIQNVLSAASLTLVV--KVLDTPGPPTNI 19979
Query: 2501 ----------TITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQ 2541
++W P+ + I + S + + + ++ K+ NL
Sbjct: 19980 TVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNLQEG 20039
Query: 2542 DSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNC 2598
+ N+ G T VK+ P+ P + S SV L WL P G
Sbjct: 20040 AIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGS 20099
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
I Y VE E+G + W + + T+ V+ L Y FRV A N G+S P E
Sbjct: 20100 RIVHYVVEALEKGQKNWVKCAVAK-STHHVVSGLRENSEYFFRVFAENQAGLSDPRE 20155
Score = 57.0 bits (136), Expect = 3e-07
Identities = 34/93 (36%), Positives = 47/93 (50%), Gaps = 3/93 (3%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ---SVASTLDT 2625
P+ P P A + +C SV L W PP G I GY VEY++ G + W++ + S +T
Sbjct: 10808 PSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPET 10867
Query: 2626 YLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
+ L G Y+FRV A N G S P+ E
Sbjct: 10868 KYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPE 10900
Score = 57.0 bits (136), Expect = 3e-07
Identities = 46/183 (25%), Positives = 78/183 (42%), Gaps = 23/183 (12%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVSSCDSG------------EITLKICNLMPQDSGIYTC 2548
+++W P + D ++ Y V CD + + ++ L+P I+
Sbjct: 12705 SLSWHIP---LEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRV 12761
Query: 2549 IATNDHGTTSTSATVKVQ-----GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
A N G + + K+ GVP+ P + + + + W P S G I GY
Sbjct: 12762 RAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGY 12821
Query: 2604 TVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV-- 2660
+E +E S +W ++ + + T L G Y FR+ A N G S PS+P+E+V
Sbjct: 12822 LIERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTA 12881
Query: 2661 RLP 2663
R+P
Sbjct: 12882 RMP 12884
Score = 56.6 bits (135), Expect = 4e-07
Identities = 42/142 (29%), Positives = 61/142 (42%), Gaps = 4/142 (2%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAA 2571
+++ Y S + + K+ NL + +A N+ G T VK P+
Sbjct: 17851 ESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSP 17910
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIED 2631
P + + S TS L W P G + GY VE + +G++ W VA + V+
Sbjct: 17911 PGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKW-SIVAESKVCNAVVTG 17969
Query: 2632 LSPGCPYQFRVSASNPWGISLP 2653
LS G YQFRV A N G S P
Sbjct: 17970 LSSGQEYQFRVKAYNEKGKSDP 17991
Score = 56.6 bits (135), Expect = 4e-07
Identities = 43/151 (28%), Positives = 60/151 (39%), Gaps = 7/151 (4%)
Query: 2535 ICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ------GVPAAPNRPIAQERSCTSVILR 2588
+ L+P + IA ND G + TS + P+ P S SV L+
Sbjct: 24086 VTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQ 24145
Query: 2589 WLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNP 2647
W P G I GY VEYR+ G W++S + D I L Y+FRV A N
Sbjct: 24146 WEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENE 24205
Query: 2648 WGISLPSEPSEFVRLPEYDAAADGATISWKE 2678
G+S P + ++ A G K+
Sbjct: 24206 TGLSRPRRTAMSIKTKLTSGEAPGIRKEMKD 24236
Score = 56.6 bits (135), Expect = 4e-07
Identities = 48/177 (27%), Positives = 71/177 (40%), Gaps = 23/177 (12%)
Query: 2502 ITWKGPDQNILDTDNSSATYTVSSCDSGE-------------ITLKICNLMPQDSGIYTC 2548
I+WK P D + Y V C++ E T +I NL +
Sbjct: 24437 ISWKPPAD---DGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRV 24493
Query: 2549 IATNDHGTTS---TSATVKVQGV---PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISG 2602
A N G + S+ V ++ P AP +P + S ++ W PP+S G I
Sbjct: 24494 SAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRN 24553
Query: 2603 YTVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
Y +E RE+ W + +T +++L G Y+FRV N G S SE SE
Sbjct: 24554 YYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISE 24610
Score = 56.2 bits (134), Expect = 5e-07
Identities = 50/186 (26%), Positives = 75/186 (40%), Gaps = 20/186 (10%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDS------------GEIT 2532
G V + K + +TW+ P I+D + Y V D+ + +
Sbjct: 13483 GPPVNVTVKEISKDSAYVTWEPP---IIDGGSPIINYVVQKRDAERKSWSTVTTECSKTS 13539
Query: 2533 LKICNLMPQDSGIYTCIATNDHGTTSTSAT---VKVQGVPAAPNRPIAQERSCTSVILRW 2589
++ NL S + A N++G T VK P + S +S + W
Sbjct: 13540 FRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGW 13599
Query: 2590 LPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG 2649
P S G I GY V++ E ++ WQ+ V +L +DL+ G Y FRVSA N G
Sbjct: 13600 KKPHSDGGSRIIGYVVDFLTEENK-WQR-VMKSLSLQYSAKDLTEGKEYTFRVSAENENG 13657
Query: 2650 ISLPSE 2655
PSE
Sbjct: 13658 EGTPSE 13663
Score = 55.8 bits (133), Expect = 6e-07
Identities = 46/175 (26%), Positives = 74/175 (42%), Gaps = 14/175 (8%)
Query: 2501 TITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIAT 2551
TI+W+ P + + D T+ V S S + LKI +L ++ A
Sbjct: 11317 TISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAE 11376
Query: 2552 NDHGT----TSTSATVKVQ-GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVE 2606
N G ST K + P+ P +P+ + + + + W P S G I+GY +E
Sbjct: 11377 NKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYME 11436
Query: 2607 YREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVR 2661
RE + + + D + L G Y+FRV A N G+S PS S+ ++
Sbjct: 11437 RREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIK 11491
Score = 55.5 bits (132), Expect = 8e-07
Identities = 53/246 (21%), Positives = 98/246 (39%), Gaps = 22/246 (8%)
Query: 2389 AAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESE 2448
+A + G++ SC + +++ + E E T E + + + V + +T+ +EE
Sbjct: 970 SAVNEAGTVSTSC-YLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQA 1028
Query: 2449 CDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPD 2508
P + AP F+ V + G +V+ C+V G PKP + WK
Sbjct: 1029 -------------GPG--EPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSG 1073
Query: 2509 QNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG- 2567
+ +Y + +GE L I D+G YT + N HG TS SA++ +
Sbjct: 1074 VPLTTGYRYKVSY---NKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEAD 1130
Query: 2568 --VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDT 2625
+ + + + T+ + + S Y EY +E + I ++ T+
Sbjct: 1131 YELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVV 1190
Query: 2626 YLVIED 2631
+ED
Sbjct: 1191 RTYVED 1196
Score = 53.9 bits (128), Expect = 2e-06
Identities = 33/101 (32%), Positives = 48/101 (47%), Gaps = 7/101 (6%)
Query: 2470 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG 2529
AP+ + L DVT GDT C + +TW I +++ + +G
Sbjct: 3488 APKIFLHLQDVTVKCGDTAQFLCVLKDDSFIDVTWTHEGAKIEESER------LKQSQNG 3541
Query: 2530 EIT-LKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVP 2569
I L ICN+ D G+Y+CI ND G +TSA + V+G P
Sbjct: 3542 NIQFLTICNVQLVDQGLYSCIVHNDCGERTTSAVLSVEGAP 3582
Score = 53.9 bits (128), Expect = 2e-06
Identities = 31/90 (34%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIW-QQSVASTLDTYL 2627
P+AP RP S ++ +RW P G I GY VE +E + +W +++ L+
Sbjct: 22536 PSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNY 22595
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSEPS 2657
+ L G YQFR A N G+S SE S
Sbjct: 22596 KVTGLVEGLEYQFRTYALNAAGVSKASEAS 22625
Score = 53.5 bits (127), Expect = 3e-06
Identities = 31/92 (33%), Positives = 50/92 (54%), Gaps = 7/92 (7%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-----SVASTL 2623
P P+ P ++++ +S+ L W PP+ G I GY VE +EEG+ W++ + +T
Sbjct: 9400 PGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTC 9459
Query: 2624 DTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
+ V+ +L Y+FRV A N G S PS+
Sbjct: 9460 E--CVVPNLKELRKYRFRVKAVNEAGESEPSD 9489
Score = 53.5 bits (127), Expect = 3e-06
Identities = 34/92 (36%), Positives = 42/92 (45%), Gaps = 1/92 (1%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTY 2626
VP P P + S+ + W P S G I GY VE +E +WQ S A
Sbjct: 14953 VPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNI 15012
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
L+ G Y+FRV A N G S PS+PSE
Sbjct: 15013 FKSSGLTDGIAYEFRVIAENMAGKSKPSKPSE 15044
Score = 53.5 bits (127), Expect = 3e-06
Identities = 42/152 (27%), Positives = 65/152 (42%), Gaps = 14/152 (9%)
Query: 2533 LKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG------VPAAPNRPIAQERSCTSVI 2586
LK+ +LM + A N G + S P P+ P + + S+
Sbjct: 22995 LKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSIS 23054
Query: 2587 LRWLPPSSTGNCTISGYTVEYREEGSQIWQQ--SVASTLDTYLVIEDLSPGCPYQFRVSA 2644
L W P G I GY +E +E+ + W + + A+ +T + DL G Y FRV+A
Sbjct: 23055 LAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAA 23114
Query: 2645 SNPWGISLPS------EPSEFVRLPEYDAAAD 2670
N G+S S EP E + +P+ + A D
Sbjct: 23115 VNVKGMSEYSESIAEIEPVERIEIPDLELADD 23146
Score = 53.1 bits (126), Expect = 4e-06
Identities = 31/96 (32%), Positives = 47/96 (48%), Gaps = 5/96 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P+ L L VT G + GRP+P I+W +Q + S+ D E
Sbjct: 3193 PQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLL-----STGFKCKFLHDGQE 3247
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
TL + P+D+ +YTC A ND+G +TSA++ V+
Sbjct: 3248 YTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVE 3283
Score = 53.1 bits (126), Expect = 4e-06
Identities = 30/71 (42%), Positives = 38/71 (53%), Gaps = 1/71 (1%)
Query: 2583 TSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRV 2642
T V L W P G I+GY VEY+EEG+Q W + T + V+ L G Y+FRV
Sbjct: 11119 TEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVT-NLECVVTGLQQGKTYRFRV 11177
Query: 2643 SASNPWGISLP 2653
A N G+ LP
Sbjct: 11178 KAENIVGLGLP 11188
Score = 52.8 bits (125), Expect = 5e-06
Identities = 33/94 (35%), Positives = 49/94 (52%), Gaps = 5/94 (5%)
Query: 2567 GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTY 2626
G P AP++PI ++ + S++++W P G+ I GY +E RE S W + S L+
Sbjct: 8596 GPPDAPDKPIVEDVTSNSMLVKWNEPKDNGS-PILGYWLEKREVNSTHWSRVNKSLLNAL 8654
Query: 2627 LV-IEDLSPGCPYQFRVSASN---PWGISLPSEP 2656
++ L G Y FRV A N P S PS+P
Sbjct: 8655 KANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDP 8688
Score = 52.8 bits (125), Expect = 5e-06
Identities = 48/187 (25%), Positives = 79/187 (42%), Gaps = 15/187 (8%)
Query: 2490 LQCKVCGRPKPTITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMP 2540
++ K K T+ W+ P + + + S +++ S E + ++
Sbjct: 20668 IEFKTVTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLEECIITTTKIIK 20727
Query: 2541 QDSGIYTCIATNDHGT----TSTSATVKVQGV-PAAPNRPIAQERSCTSVILRWLPPSST 2595
+ I+ A N +G S S K V P P P + + S+ + W P +
Sbjct: 20728 GNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIAD 20787
Query: 2596 GNCTISGYTVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPS 2654
G ISGY +E R++ S W + + T+ DT + L+ YQ+RV A N G S
Sbjct: 20788 GGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFS 20847
Query: 2655 EPSEFVR 2661
EPSEF +
Sbjct: 20848 EPSEFYK 20854
Score = 52.8 bits (125), Expect = 5e-06
Identities = 56/202 (27%), Positives = 79/202 (39%), Gaps = 33/202 (16%)
Query: 2468 EVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCD 2527
E PEF +PL + T +G+ V + P+P +TW Q I DN YT S D
Sbjct: 25382 ERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDK-KYTFES-D 25439
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPN---RPIAQ------ 2578
G L I ++ D YT +A N +G S A + V P + RP+ +
Sbjct: 25440 KGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANA 25499
Query: 2579 -----ERSCTSVILRWLPP-----SSTGNCTISGYTVEYREEGSQIWQQSVASTLDTY-L 2627
+ C + + +PP G G +E EG LD Y L
Sbjct: 25500 ECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEG-----------LDYYAL 25548
Query: 2628 VIEDLSPGCPYQFRVSASNPWG 2649
I D P +RV+A+N G
Sbjct: 25549 HIRDTLPEDTGYYRVTATNTAG 25570
Score = 52.4 bits (124), Expect = 7e-06
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 1/90 (1%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYL 2627
P P+ P + S + + W PP G +I+GY +E +E+ S W S + + +
Sbjct: 12091 PGRPDPPEVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPERRM 12150
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSEPS 2657
+++L P YQFRV A N GI PS PS
Sbjct: 12151 KVQNLLPDHEYQFRVKAENEIGIGEPSLPS 12180
Score = 51.6 bits (122), Expect = 1e-05
Identities = 45/172 (26%), Positives = 78/172 (45%), Gaps = 17/172 (9%)
Query: 2501 TITWKGPDQN---------ILDTDNSSATY-TVSSCDSGEITLKICNLMPQDSGIYTCIA 2550
++TW+ P+ + I D +S + T + + +++ + +++ + A
Sbjct: 6903 SLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRA 6962
Query: 2551 TNDHGTTSTSAT---VKVQGVPAAPNRPI---AQERSCTSVILRWLPPSSTGNCTISGYT 2604
N G SA VKV P+ P+ + +++ +SV L+W PP G I GY
Sbjct: 6963 QNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYI 7022
Query: 2605 VEYREEGSQIW-QQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
+E EEG W + ++ + + L G Y +RVSA N G+S PSE
Sbjct: 7023 IERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSE 7074
Score = 51.6 bits (122), Expect = 1e-05
Identities = 32/104 (30%), Positives = 48/104 (46%), Gaps = 3/104 (2%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL--DTY 2626
P P+ P + + S L W P G I+GY VE+++ G + W + T T
Sbjct: 14368 PGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQ 14427
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAAD 2670
V+ DL Y FR+SA N G+ P+ + V + E + A D
Sbjct: 14428 FVVPDLQTKEKYNFRISAINDAGVGEPAVIPD-VEIVEREMAPD 14470
Score = 51.6 bits (122), Expect = 1e-05
Identities = 30/91 (32%), Positives = 48/91 (52%), Gaps = 2/91 (2%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIW-QQSVASTLDTYLVIE 2630
P +P+ + +V L+W P TG I+ Y VE R+ + W + + ++ L+ +
Sbjct: 15055 PGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVS 15114
Query: 2631 DLSPGCPYQFRVSASNPWG-ISLPSEPSEFV 2660
L+ Y+FRV A N G IS PSEPS+ +
Sbjct: 15115 GLTEDAAYEFRVIAKNAAGAISPPSEPSDAI 15145
Score = 50.8 bits (120), Expect = 2e-05
Identities = 45/178 (25%), Positives = 77/178 (43%), Gaps = 15/178 (8%)
Query: 2499 KPTITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
K ++TW P Q+ + + S +TV + + +LK+ L+ + ++ +
Sbjct: 17430 KCSLTWSPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIM 17489
Query: 2550 ATNDHGTTST--SATVKVQGVPAAPNRPIAQERSCT---SVILRWLPPSSTGNCTISGYT 2604
A N +G SA V ++ P P + E + S+ + W P S G I GY
Sbjct: 17490 AVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYI 17549
Query: 2605 VEYREEGSQIW-QQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVR 2661
VE R+ W + + D L + L+ Y+FRVSA N G+ PS + + +
Sbjct: 17550 VEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYK 17607
Score = 50.4 bits (119), Expect = 3e-05
Identities = 56/219 (25%), Positives = 87/219 (39%), Gaps = 31/219 (14%)
Query: 2454 PNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILD 2513
P ++E+ F EV+ + PL D G + I+ V R TW +L
Sbjct: 6787 PVRNLEVTE-TFDGEVSLAWEEPLTD-----GGSKIIGYVVERRDIKRKTW------VLA 6834
Query: 2514 TDNS-SATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQG-- 2567
TD + S +TV+ G + ++ A N GT T V+ +
Sbjct: 6835 TDRAESCEFTVTGLQKGGVEY-----------LFRVSARNRVGTGEPVETDNPVEARSKY 6883
Query: 2568 -VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSV-ASTLDT 2625
VP P + + V L W PP G I+ Y +E R++ S W ++ D
Sbjct: 6884 DVPGPPLNVTITDVNRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDL 6943
Query: 2626 YLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
+ D+ G Y FRV A N G+ PS + FV++ +
Sbjct: 6944 SATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVAD 6982
Score = 50.4 bits (119), Expect = 3e-05
Identities = 47/168 (27%), Positives = 68/168 (40%), Gaps = 19/168 (11%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVSSCDSGEITL------------KICNLMPQDSGIYTC 2548
+ITW+ P +LD + Y V ++ + KI L S +
Sbjct: 16746 SITWEPP---LLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRV 16802
Query: 2549 IATNDHGT---TSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTV 2605
A N++G T+ +KV VP P + + + SV L W P G I Y V
Sbjct: 16803 TAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIV 16862
Query: 2606 EYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP 2653
E + + S+ W + A VI +L+ G Y FRV A N G S P
Sbjct: 16863 EMQAKHSEKWSE-CARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDP 16909
Score = 50.1 bits (118), Expect = 3e-05
Identities = 33/98 (33%), Positives = 45/98 (45%), Gaps = 4/98 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F++ V CL G T KV GRP P W Q I+ + T+ V + G
Sbjct: 1411 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIV----NDYTHKVVIKEDGT 1466
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGV 2568
+L I P DSG +T +A N G +S S + V+ V
Sbjct: 1467 QSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAV 1504
Score = 49.7 bits (117), Expect = 4e-05
Identities = 33/88 (37%), Positives = 45/88 (51%), Gaps = 3/88 (3%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P RP A + SV L+W P+ G I+GY VE +E W + S + +DT+ +
Sbjct: 16137 PGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVT 16196
Query: 2631 DLSPGCPYQFRVSASNPWGISLPSEPSE 2658
L Y+FRV A N G+ SEPSE
Sbjct: 16197 GLVEDHRYEFRVIARNAAGVF--SEPSE 16222
Score = 49.7 bits (117), Expect = 4e-05
Identities = 51/196 (26%), Positives = 81/196 (41%), Gaps = 21/196 (10%)
Query: 2477 LVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG-----EI 2531
LV V G ++ K R TITW+ P +D Y V ++ +
Sbjct: 23226 LVKVYDTPGPCPSVKVKEVSRDSVTITWEIPT---IDGGAPVNNYIVEKREAAMRAFKTV 23282
Query: 2532 TLKICNLMPQDSGI-------YTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQERS 2581
T K + + SG+ + + N +G TS V V VP P + + +
Sbjct: 23283 TTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVT 23342
Query: 2582 CTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYL--VIEDLSPGCPYQ 2639
++V L W P G ++GY +E + G++ W + V + T L + L+ G Y
Sbjct: 23343 KSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMK-VVTLKPTVLEHTVTSLNEGEQYL 23401
Query: 2640 FRVSASNPWGISLPSE 2655
FR+ A N G+S P E
Sbjct: 23402 FRIRAQNEKGVSEPRE 23417
Score = 49.7 bits (117), Expect = 4e-05
Identities = 46/177 (25%), Positives = 70/177 (39%), Gaps = 23/177 (12%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVSSCDSGE------------ITLKICNLMPQDSGIYTC 2548
TI+W+ P+ LD + Y V D+ T K L + ++
Sbjct: 23545 TISWEPPE---LDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRV 23601
Query: 2549 IATNDHGTTSTSATVKVQ-----GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
ATN G S + ++ +P P + S + L W PP G ++GY
Sbjct: 23602 AATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGY 23661
Query: 2604 TVEYREEGSQIWQQ--SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
VE +E + W + V T+ Y L+ G Y+ RV+A N G PS PS+
Sbjct: 23662 IVERKEVRADRWVRVNKVPVTMTRYR-STGLTEGLEYEHRVTAINARGSGKPSRPSK 23717
Score = 49.3 bits (116), Expect = 6e-05
Identities = 48/203 (23%), Positives = 78/203 (38%), Gaps = 14/203 (6%)
Query: 2472 EFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQN--------ILDTDNSSATYTV 2523
+F V+V + G + L+ V R + W P+ + I++ ++
Sbjct: 8880 KFAAARVEVFDVPGPVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWR 8939
Query: 2524 SSCDSGEITLKICNLMPQDSGIYTCIATNDHGT-----TSTSATVKVQGVPAAPNRPIAQ 2578
++ I L+ + IA N G V G P +P R
Sbjct: 8940 QPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYT 8999
Query: 2579 ERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGCP 2637
ER+ +++ L W P S G I GY +E R +++ + T ++E+L
Sbjct: 9000 ERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQM 9059
Query: 2638 YQFRVSASNPWGISLPSEPSEFV 2660
Y+FRV A N G S PS P V
Sbjct: 9060 YEFRVKAVNEIGESEPSLPLNVV 9082
Score = 49.3 bits (116), Expect = 6e-05
Identities = 71/323 (21%), Positives = 121/323 (37%), Gaps = 34/323 (10%)
Query: 2398 KKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTS 2457
KK W ++ + E + KN G L + VK N ESE ++ S
Sbjct: 24561 KKQNKWISVTTEEIRETVFSVKNLIEG-------LEYEFRVKCENLGGESEWSEI----S 24609
Query: 2458 MEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNS 2517
I + + AP F L ++ L CKV G PKP + W + I+
Sbjct: 24610 EPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEII---AD 24666
Query: 2518 SATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA 2577
Y + G L I ++ D+ +Y ATN G+ S +A+++V+ VPA + P
Sbjct: 24667 GLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVE-VPAKIHLPKT 24725
Query: 2578 QERSCTSVILRW------LPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIED 2631
E LR +P S + I+ + + + +Q V + + +
Sbjct: 24726 LEGMGAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNG 24785
Query: 2632 LSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE-------YDAAADGATISWKENFDSAY 2684
+ + V A N +GI + + +P+ D + D ++W E
Sbjct: 24786 VERKDAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGG 24845
Query: 2685 TELNEIGRGRFSIVKKCIHKATR 2707
+++ IV+KC A R
Sbjct: 24846 SKITNY------IVEKCATTAER 24862
Score = 48.9 bits (115), Expect = 7e-05
Identities = 29/95 (30%), Positives = 46/95 (48%), Gaps = 4/95 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P FL L + C G I + V G P PT+TW ++ + +S YT+ +G
Sbjct: 3767 PHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLC----TSVYYTIIHNPNGS 3822
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV 2565
T + + +DSG+Y C A N G ++ +A + V
Sbjct: 3823 GTFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3857
Score = 48.5 bits (114), Expect = 1e-04
Identities = 49/163 (30%), Positives = 73/163 (44%), Gaps = 20/163 (12%)
Query: 2418 GKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPL 2477
G+ + T P K G + S+K TN S ++ + E PNF+Q L
Sbjct: 61 GRAKLTIPAVTKANSG-RYSLKATNGSGQAT-STAELLVKAETAPPNFVQR--------L 110
Query: 2478 VDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEI-TLKIC 2536
+T G V LQ +V G P P + + I SS + +S G++ +L I
Sbjct: 111 QSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEI----QSSLDFQISQ--EGDLYSLLIA 164
Query: 2537 NLMPQDSGIYTCIATNDHGTTSTSATVKVQG---VPAAPNRPI 2576
P+DSG Y+ ATN G +++A + VQG VPA + I
Sbjct: 165 EAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTI 207
Score = 48.5 bits (114), Expect = 1e-04
Identities = 33/99 (33%), Positives = 49/99 (49%), Gaps = 3/99 (3%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P +P + SV L W P G ++GY VE R+ S+ W + + + + +
Sbjct: 13972 PGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVT 14031
Query: 2631 DLSPGCPYQFRVSASNPWG-ISLPSEPSE-FVRLPEYDA 2667
DL G Y+FR+ A N G IS PSE +E + EY+A
Sbjct: 14032 DLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEA 14070
Score = 48.5 bits (114), Expect = 1e-04
Identities = 30/95 (31%), Positives = 44/95 (46%), Gaps = 2/95 (2%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQ--QSVASTLDTY 2626
P P + + + +S+ L W P G ++GY VE R+ + W + T
Sbjct: 20862 PGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTE 20921
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVR 2661
V+ +L PG Y FRVSA N G P E +E V+
Sbjct: 20922 YVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQ 20956
Score = 48.1 bits (113), Expect = 1e-04
Identities = 36/127 (28%), Positives = 46/127 (36%), Gaps = 1/127 (0%)
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRW 2589
+ + +I D G Y + N HG +KV VP E V L W
Sbjct: 6746 QTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLAW 6805
Query: 2590 LPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSP-GCPYQFRVSASNPW 2648
P + G I GY VE R+ + W + + L G Y FRVSA N
Sbjct: 6806 EEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSARNRV 6865
Query: 2649 GISLPSE 2655
G P E
Sbjct: 6866 GTGEPVE 6872
Score = 47.8 bits (112), Expect = 2e-04
Identities = 34/104 (32%), Positives = 47/104 (45%), Gaps = 15/104 (14%)
Query: 2567 GVPAAPNRPIAQERSC-------------TSVILRWLPPSSTGNCTISGYTVEYREEGSQ 2613
G P+ P+ P+ +C SV L W P+ G I+GY VE R+
Sbjct: 20448 GKPSHPSEPVLAIDACEPPRNVRITDISKNSVSLSWQQPAFDGGSKITGYIVERRDLPDG 20507
Query: 2614 IW-QQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG-ISLPSE 2655
W + S + +T +I L+ Y+FRV A N G IS PSE
Sbjct: 20508 RWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSE 20551
Score = 47.8 bits (112), Expect = 2e-04
Identities = 30/99 (30%), Positives = 44/99 (44%), Gaps = 2/99 (2%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVAS--TLDT 2625
VP AP P + S+ L W P S G I Y +E RE+ S W + ++ +T
Sbjct: 21846 VPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISET 21905
Query: 2626 YLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
+ L+ G Y+F V A N G+ S S ++ E
Sbjct: 21906 RFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCRE 21944
Score = 47.8 bits (112), Expect = 2e-04
Identities = 29/105 (27%), Positives = 45/105 (42%), Gaps = 7/105 (6%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYL 2627
P P P + + TSV L W P G ++GY +E ++ W + + T
Sbjct: 23728 PGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREY 23787
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSE------PSEFVRLPEYD 2666
+ L G Y+FRV A N G P+E +E + P+Y+
Sbjct: 23788 TLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYE 23832
Score = 47.4 bits (111), Expect = 2e-04
Identities = 30/90 (33%), Positives = 42/90 (46%), Gaps = 6/90 (6%)
Query: 2483 LLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQD 2542
L G V CK+ G P P I W + I + Y + G +L+I ++P+D
Sbjct: 1257 LEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGER----YQMDFLQDGRASLRIPVVLPED 1312
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAP 2572
GIYT A+N G S + V+ PAAP
Sbjct: 1313 EGIYTAFASNIKGNAICSGKLYVE--PAAP 1340
Score = 47.4 bits (111), Expect = 2e-04
Identities = 27/87 (31%), Positives = 40/87 (45%), Gaps = 1/87 (1%)
Query: 2573 NRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIW-QQSVASTLDTYLVIED 2631
N P + + +SV L W P G ++GY +E +E + W + + T +
Sbjct: 24029 NPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTG 24088
Query: 2632 LSPGCPYQFRVSASNPWGISLPSEPSE 2658
L P YQFR+ A N G+S S SE
Sbjct: 24089 LVPDAEYQFRIIAQNDVGLSETSPASE 24115
Score = 46.6 bits (109), Expect = 4e-04
Identities = 80/342 (23%), Positives = 124/342 (36%), Gaps = 60/342 (17%)
Query: 2349 QVLAVNQQNMCLVYQP-----ASDHSPAAEGWVPGSILAPLT-----KATAAESSDGSIK 2398
+V A+N+Q +P A D A E ++ +LA LT K + G +
Sbjct: 7355 RVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPE 7414
Query: 2399 KSCSWHT----LRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEE-SECDDLD 2453
+W L+ KR +EN K I+ +K S T E + C
Sbjct: 7415 PKITWTKADMILKQDKRITIENVPKKSTV------TIVDSKRSDTGTYIIEAVNVC---- 7464
Query: 2454 PNTSMEILNPNFIQEVAPEFLVPLVDVT---CLL--------GDTVILQCKVCGRPKPTI 2502
+ ++ N + + P + DVT CLL G + I V R +
Sbjct: 7465 -GRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSE 7523
Query: 2503 TWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT----TS 2558
W + DT+ K L+P I+ A N +G +
Sbjct: 7524 VWHKLSSTVKDTN-----------------FKATKLIPNKEYIFRVAAENMYGVGEPVQA 7566
Query: 2559 TSATVKVQ-GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ 2617
+ T K Q P P R + + +V L W P G I+GY VE + + W +
Sbjct: 7567 SPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVR 7626
Query: 2618 -SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
+ DT ++ L+ Y+FRV A N G PS+ +E
Sbjct: 7627 CNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTE 7668
Score = 46.6 bits (109), Expect = 4e-04
Identities = 26/88 (29%), Positives = 40/88 (45%), Gaps = 1/88 (1%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDT-YL 2627
P P P + S T++ L W PP+ G I GY V+ + G+ W + +
Sbjct: 8697 PPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQY 8756
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSE 2655
++++ G Y+ RVSA N G P E
Sbjct: 8757 TVKEIREGADYKLRVSAVNAAGEGPPGE 8784
Score = 46.6 bits (109), Expect = 4e-04
Identities = 36/130 (27%), Positives = 50/130 (38%), Gaps = 8/130 (6%)
Query: 2529 GEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGV------PAAPNRPIAQERSC 2582
GE+ L++ L+ + A N G + S Q P PN P + +
Sbjct: 16487 GELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITR 16546
Query: 2583 TSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVAST--LDTYLVIEDLSPGCPYQF 2640
+SV L W P G C I GY VE + W T T + +E L Y F
Sbjct: 16547 SSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNF 16606
Query: 2641 RVSASNPWGI 2650
R+ A N G+
Sbjct: 16607 RICAINKAGV 16616
Score = 46.6 bits (109), Expect = 4e-04
Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 3/91 (3%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P P + + ++ L+W PP G I GY++E R+ G++ W + + + +
Sbjct: 21553 PGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQ-GNERWVRCNFTDVSECQYTVT 21611
Query: 2631 DLSPGCPYQFRVSASNPWG-ISLPSEPSEFV 2660
LSPG Y+FR+ A N G IS PS+ S +
Sbjct: 21612 GLSPGDRYEFRIIARNAVGTISPPSQSSGII 21642
Score = 46.2 bits (108), Expect = 5e-04
Identities = 32/104 (30%), Positives = 45/104 (43%), Gaps = 3/104 (2%)
Query: 2470 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG 2529
AP F PL V L G T + + G P P ++W Q I S+ S G
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVI---STSTLPGVQISFSDG 61
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPN 2573
L I + +SG Y+ ATN G +++A + V+ A PN
Sbjct: 62 RAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPN 105
Score = 46.2 bits (108), Expect = 5e-04
Identities = 30/95 (31%), Positives = 46/95 (48%), Gaps = 5/95 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F+ + + +GD L V G PKP I W +L T ++ + D +
Sbjct: 3649 PIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFF--NGVLLTPSADYKFVF---DGDD 3703
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV 2565
+L I +D G YTC+A+ND+G T SA +K+
Sbjct: 3704 HSLIILFTKLEDEGEYTCMASNDYGKTICSAYLKI 3738
Score = 46.2 bits (108), Expect = 5e-04
Identities = 30/110 (27%), Positives = 42/110 (38%), Gaps = 8/110 (7%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVAST--LDTY 2626
P P+ P + S +SV L W P G + GY VE +E + W T
Sbjct: 18698 PGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQ 18757
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSE------PSEFVRLPEYDAAAD 2670
+ L Y FR+ A N G+ P+ E + PE + AD
Sbjct: 18758 FTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDAD 18807
Score = 45.4 bits (106), Expect = 8e-04
Identities = 25/81 (30%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 2585 VILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVAST-LDTYLVIEDLSPGCPYQFRVS 2643
V L+W PP + G I Y +E +E W ++ + D + D+ G QF+V
Sbjct: 7895 VDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVR 7954
Query: 2644 ASNPWGISLPSEPSEFVRLPE 2664
A N G+ PSEP+E + + +
Sbjct: 7955 AENEAGVGHPSEPTEILSIED 7975
Score = 45.4 bits (106), Expect = 8e-04
Identities = 54/224 (24%), Positives = 80/224 (35%), Gaps = 60/224 (26%)
Query: 2496 GRPKP-----------TITWKGPDQN--------ILDTDNSSATYTVSSCDSG--EITLK 2534
GRP P T+ W P+ + L+ +T V S E +K
Sbjct: 12092 GRPDPPEVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPERRMK 12151
Query: 2535 ICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQ---------------- 2578
+ NL+P + A N+ G G P+ P+RP+
Sbjct: 12152 VQNLLPDHEYQFRVKAENEIGI----------GEPSLPSRPVVAKDPIEPPGPPTNFRVV 12201
Query: 2579 ERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQI-----WQQ--SVASTLDTYLVIED 2631
+ + S+ L W P G I GY VE R + + W++ + A + +
Sbjct: 12202 DTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTS 12261
Query: 2632 LSPGCPYQFRVSASNPWGISLPSE------PSEFVRLPEYDAAA 2669
L Y+FRV A N GI P+E P E + PE D A
Sbjct: 12262 LDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDA 12305
Score = 45.4 bits (106), Expect = 8e-04
Identities = 46/155 (29%), Positives = 60/155 (38%), Gaps = 14/155 (9%)
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV------QGVPAAPNRPIAQERSCT 2583
E TLK L + A N G S K Q P P P + + +
Sbjct: 13239 ERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRS 13298
Query: 2584 SVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLD-TYLVIEDLSPGCPYQFR 2641
SV L W P+ G I GY VE + S W + ++ L T + L YQFR
Sbjct: 13299 SVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFR 13358
Query: 2642 VSASNPWGISLPSE------PSEFVRLPEYDAAAD 2670
V A N G S PS+ P + + PE + AD
Sbjct: 13359 VYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDAD 13393
Score = 45.4 bits (106), Expect = 8e-04
Identities = 51/277 (18%), Positives = 107/277 (38%), Gaps = 25/277 (9%)
Query: 2304 QPGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQ 2363
+P + E K N + S++ ++ Y+L+ VS + A N + C
Sbjct: 26855 EPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQC---- 26910
Query: 2364 PASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEAT 2423
S A V + P + S D S++ S S +++M + + ++
Sbjct: 26911 -----SATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSS 26965
Query: 2424 GPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQE------------VAP 2471
++ +S + +S +ES + + ++ M I N ++ + P
Sbjct: 26966 SASSMTEMKFASMSAQSMSSMQESFVE-MSSSSFMGISNMTQLESSTSKMLKAGIRGIPP 27024
Query: 2472 EFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEI 2531
+ D++ G + + C G P P +TW + I + + + + D
Sbjct: 27025 KIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGR--FHIENTDD-LT 27081
Query: 2532 TLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGV 2568
TL I ++ QD G+YT N+ G+ S + + ++ +
Sbjct: 27082 TLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIRSI 27118
Score = 45.1 bits (105), Expect = 0.001
Identities = 30/88 (34%), Positives = 42/88 (47%), Gaps = 3/88 (3%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P +P + SV L+W P G I+GY VE RE W + + + +TY +
Sbjct: 19383 PGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVT 19442
Query: 2631 DLSPGCPYQFRVSASNPWGISLPSEPSE 2658
+L+ Y+FRV A N SEPSE
Sbjct: 19443 ELTEDQRYEFRVFARN--AADSVSEPSE 19468
Score = 44.7 bits (104), Expect = 0.001
Identities = 43/174 (24%), Positives = 71/174 (40%), Gaps = 21/174 (12%)
Query: 2502 ITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATN 2552
++WK PD + I +T + D G T + +L+ + + A N
Sbjct: 9625 LSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAEN 9684
Query: 2553 DHGTTSTSATVK---VQGVPAAPNRPIAQERSC---TSVILRWLPPSSTGNCTISGYTVE 2606
G T++ + P+ PI + +V L W PP + G ++ Y VE
Sbjct: 9685 RFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVE 9744
Query: 2607 ---YREEGS--QIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPS 2654
+ G+ + W+Q + + +EDL G Y+FRV A N G+S PS
Sbjct: 9745 CLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPS 9798
Score = 44.3 bits (103), Expect = 0.002
Identities = 48/199 (24%), Positives = 76/199 (38%), Gaps = 32/199 (16%)
Query: 2487 TVILQCKVCGRPKPT--------------ITWKGPDQN--------ILDTDNSSA-TYTV 2523
T + KV G P P +TW+ P+ + +L+ + TY
Sbjct: 8164 TASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIP 8223
Query: 2524 SSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQE- 2579
+++ + +L+P + A N G V Q P+ P+ E
Sbjct: 8224 VMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEV 8283
Query: 2580 --RSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLD--TYLVIEDLSPG 2635
+ ++ + W PP G I GY +E +G + W++ + TY + L G
Sbjct: 8284 HNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTY-TAKGLEEG 8342
Query: 2636 CPYQFRVSASNPWGISLPS 2654
YQFRV A N GIS PS
Sbjct: 8343 KEYQFRVRAENAAGISEPS 8361
Score = 44.3 bits (103), Expect = 0.002
Identities = 30/88 (34%), Positives = 43/88 (48%), Gaps = 2/88 (2%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P RP A + +V L+W P+ G I+GY VE ++ W + S + L+T +
Sbjct: 18301 PGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVS 18360
Query: 2631 DLSPGCPYQFRVSASNPWG-ISLPSEPS 2657
L Y+FRV A N G S PS+ S
Sbjct: 18361 GLVEDQRYEFRVIARNAAGNFSEPSDSS 18388
Score = 44.3 bits (103), Expect = 0.002
Identities = 30/109 (27%), Positives = 46/109 (42%), Gaps = 4/109 (3%)
Query: 2546 YTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTV 2605
Y A + S + Q AP RP + + ++V L W P+ G + GY +
Sbjct: 22611 YALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGYII 22670
Query: 2606 EYR---EEGSQIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI 2650
E + E G W + + D + + LS G Y+FRV A N G+
Sbjct: 22671 ERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGV 22719
Score = 43.9 bits (102), Expect = 0.002
Identities = 34/119 (28%), Positives = 50/119 (42%), Gaps = 8/119 (6%)
Query: 2550 ATNDHGTTSTSATVKVQGV--PAAPNRPIAQ----ERSCTSVILRWLPPSSTGNCTISGY 2603
A N+ G S ++ + P +P P + + + W PP G I GY
Sbjct: 7955 AENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGY 8014
Query: 2604 TVEYREEGSQIWQQSVASTLD--TYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
VE G++ W + + + + V E + P Y RV A N G+S PSE SE V
Sbjct: 8015 HVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENV 8073
Score = 43.9 bits (102), Expect = 0.002
Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 4/96 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F L + C G +V + +V G P PT+ W+ Q + N +
Sbjct: 25490 PMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHE----GLDY 25545
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
L I + +P+D+G Y ATN G+TS A ++V+
Sbjct: 25546 YALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVE 25581
Score = 43.5 bits (101), Expect = 0.003
Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 2/94 (2%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL--DTY 2626
P P P +++S + L W P S G I GY VE ++ G+ W + L
Sbjct: 11499 PGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCA 11558
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
+ L G Y+FR+ A+N G P E +E V
Sbjct: 11559 FRVPGLIEGNEYRFRIKAANIVGEGEPRELAESV 11592
Score = 43.5 bits (101), Expect = 0.003
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 4/89 (4%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYL 2627
P PI +R+ + L+W P G I+GY VE R+ W + S + ++T
Sbjct: 17218 PPGTPEPIMVKRN--EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQF 17275
Query: 2628 VIEDLSPGCPYQFRVSASNPWG-ISLPSE 2655
+ L+ Y+FRV A N G IS PS+
Sbjct: 17276 TVSGLTEDQRYEFRVIAKNAAGAISKPSD 17304
Score = 43.5 bits (101), Expect = 0.003
Identities = 27/111 (24%), Positives = 45/111 (40%), Gaps = 5/111 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P + L D T K G P+PT W + I Y +S D G
Sbjct: 26547 PVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAI----TQGGKYKLSE-DKGG 26601
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERS 2581
L+I DSG+YTC N G+ S+S + ++ + + ++ +++
Sbjct: 26602 FFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKT 26652
Score = 43.1 bits (100), Expect = 0.004
Identities = 42/167 (25%), Positives = 63/167 (37%), Gaps = 18/167 (10%)
Query: 2501 TITWKGPD--------QNILDTDNSSATY---TVSSCDSGEITLKICNLMPQDSGIYTCI 2549
T+TW P+ Q IL+ +T +S E K+ L + + +
Sbjct: 21864 TLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVM 21923
Query: 2550 ATNDHGTTSTSATVKV------QGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
A N G S ++ P P + S T+V L W P G I GY
Sbjct: 21924 AENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGY 21983
Query: 2604 TVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVSASNPWG 2649
+E + W + + + + T + DL G Y+FRVSA N G
Sbjct: 21984 IIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAG 22030
Score = 42.7 bits (99), Expect = 0.005
Identities = 23/65 (35%), Positives = 31/65 (47%)
Query: 2587 LRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASN 2646
L+W P G I+ Y VE R+ + WQ + DT + L+ G Y FRV+A N
Sbjct: 7797 LKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAEN 7856
Query: 2647 PWGIS 2651
G S
Sbjct: 7857 AIGQS 7861
Score = 42.0 bits (97), Expect = 0.009
Identities = 29/97 (29%), Positives = 42/97 (43%), Gaps = 5/97 (5%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G V+ C++ G P P I W + I + N S S +L+I N DSG
Sbjct: 26843 GQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSI-----SRSRNVYSLEIRNASVSDSG 26897
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERS 2581
YT A N G S +A++ V + P+R + S
Sbjct: 26898 KYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTS 26934
Score = 40.4 bits (93), Expect = 0.026
Identities = 41/170 (24%), Positives = 65/170 (38%), Gaps = 23/170 (13%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVS----------SCDSGEITLKI--CNLMPQDSGIYTC 2548
TI+W+ P LD S T + S + ++T ++ NL+ + +
Sbjct: 11714 TISWENP----LDNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRV 11769
Query: 2549 IATNDHGTTSTSAT------VKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISG 2602
A N G T T + P P ++ T V L+W P G
Sbjct: 11770 CAENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLS 11829
Query: 2603 YTVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGIS 2651
Y VE R +GS W++ S +T+ +++ Y+FRV N G S
Sbjct: 11830 YHVERRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNEGGES 11879
Score = 40.4 bits (93), Expect = 0.026
Identities = 43/191 (22%), Positives = 74/191 (38%), Gaps = 19/191 (9%)
Query: 2376 VPGSILAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNK 2435
VP S+ LT+ A S S KK+ + + + T E+ + K
Sbjct: 26175 VPRSVFPELTRTEAYAVS--SFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMK 26232
Query: 2436 VSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVC 2495
+ E S EE +T+ +I +A L +T G++ C
Sbjct: 26233 SAALEEKSLEEK-------STTRKIKTT-----LAARILTKPRSMTVYEGESARFSCDTD 26280
Query: 2496 GRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHG 2555
G P PT+TW Q + ++SA + V++ + T +I ++ D G Y+ + N G
Sbjct: 26281 GEPVPTVTWLRKGQVL----STSARHQVTT-TKYKSTFEISSVQASDEGNYSVVVENSEG 26335
Query: 2556 TTSTSATVKVQ 2566
T+ +Q
Sbjct: 26336 KQEAEFTLTIQ 26346
Score = 40.0 bits (92), Expect = 0.035
Identities = 30/105 (28%), Positives = 43/105 (40%), Gaps = 3/105 (2%)
Query: 2468 EVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCD 2527
+V P F+ L +V G + ++ + G P P I W I+ +
Sbjct: 1507 QVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTK-- 1564
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAP 2572
GE LKI + + QDS YT A N G +T V V+ A P
Sbjct: 1565 -GEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEP 1608
Score = 39.7 bits (91), Expect = 0.045
Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 7/109 (6%)
Query: 2459 EILNPNFIQEVAPEFLV-PLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNS 2517
E+++P+ V P ++ PL D G QC+V G ++W D+ I
Sbjct: 3286 EVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLK-VSWYSKDKKI----KP 3340
Query: 2518 SATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
S + ++ + L+I P+D G YT +A+N G S++A + ++
Sbjct: 3341 SRFFRMTQFED-TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLE 3388
Score = 39.3 bits (90), Expect = 0.059
Identities = 27/88 (30%), Positives = 39/88 (44%), Gaps = 1/88 (1%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTY 2626
VP P +E + +V L W PP G I Y +E R G++ + + L
Sbjct: 10411 VPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRK 10470
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPS 2654
++ L G Y++RVSA N G PS
Sbjct: 10471 YTVKGLKEGDTYEYRVSAVNIVGQGKPS 10498
Score = 38.1 bits (87), Expect = 0.13
Identities = 31/110 (28%), Positives = 43/110 (39%), Gaps = 8/110 (7%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQ--QSVASTLDTY 2626
P P P + S +S+ + W P G I+GY VE WQ A T
Sbjct: 15451 PGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATS 15510
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGIS----LPSEPSEFVRL--PEYDAAAD 2670
I L+ Y+ R+ A N G+ +P P R+ PE + AD
Sbjct: 15511 YTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDAD 15560
Score = 37.7 bits (86), Expect = 0.17
Identities = 26/102 (25%), Positives = 45/102 (44%), Gaps = 9/102 (8%)
Query: 2466 IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSS--ATYTV 2523
++ AP + + LG C++ P W + I ++D S ++ +
Sbjct: 4524 VKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYI 4583
Query: 2524 SSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV 2565
SS L+I D G YTC A+N++G+ S +AT+ V
Sbjct: 4584 SS-------LEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4618
Score = 37.4 bits (85), Expect = 0.22
Identities = 35/132 (26%), Positives = 54/132 (40%), Gaps = 9/132 (6%)
Query: 2435 KVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKV 2494
K S ++ SS ES +++ ++ I+E P PLVD GD V L +
Sbjct: 4400 KPSEEKEESSSESGTEEV-ATVKIQEAEGGLIKEDGPMIHTPLVDTVSEEGDIVHLTTSI 4458
Query: 2495 CGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQD-SGIYTCIATND 2553
+ + W ++ + + D TL I + +D G Y C A ND
Sbjct: 4459 TNAKE--VNWYFENKLVPSDEKFKCLQ-----DQNTYTLVIDKVNTEDHQGEYVCEALND 4511
Query: 2554 HGTTSTSATVKV 2565
G T+TSA + V
Sbjct: 4512 SGKTATSAKLTV 4523
Score = 36.6 bits (83), Expect = 0.38
Identities = 48/191 (25%), Positives = 71/191 (37%), Gaps = 26/191 (13%)
Query: 2501 TITWKGPDQN--------ILDTDNSSATYTVSSCDSGEIT---LKICNLMPQDSGIYTCI 2549
T+ W PD + I++ + S + C+ IT L++ L +
Sbjct: 17531 TVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIK-CNKRRITDLRLRVTGLTEDHEYEFRVS 17589
Query: 2550 ATNDHGTTSTS-ATVKVQGV-----PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
A N G S ATV + P P + + S+ L W P G I GY
Sbjct: 17590 AENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGY 17649
Query: 2604 TVEYREEGSQIWQQSVAST--LDTYLVIEDLSPGCPYQFRVSASNPWGI----SLPS--E 2655
VE + + WQ T T I L+ Y+ RV A N G+ S+P +
Sbjct: 17650 VVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVK 17709
Query: 2656 PSEFVRLPEYD 2666
P + + PE D
Sbjct: 17710 PEDKLEAPELD 17720
Score = 36.2 bits (82), Expect = 0.50
Identities = 47/199 (23%), Positives = 71/199 (35%), Gaps = 20/199 (10%)
Query: 2381 LAPLTKATAAESSDGSIKKSCSWHTLRMR---KRAEVENTGKNEATGPRKPKDILGNKVS 2437
L PL TA E S +R++ + T K I +S
Sbjct: 5627 LTPLKDVTAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLS 5686
Query: 2438 VKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGR 2497
+ +T S E + + +L E P F L D T + D VILQC++
Sbjct: 5687 IDDT-SQIRVEAMGMSSEAKLTVL------EGDPYFTGKLQDYTGVEKDEVILQCEISKA 5739
Query: 2498 PKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTT 2557
P + W + I + N+ V D + L + + D G YTC D GT
Sbjct: 5740 DAP-VKWFKDGKEIKPSKNA-----VIKADGKKRMLILKKALKSDIGQYTC----DCGTD 5789
Query: 2558 STSATVKVQGVPAAPNRPI 2576
TS + ++ RP+
Sbjct: 5790 KTSGKLDIEDREIKLVRPL 5808
Score = 35.8 bits (81), Expect = 0.65
Identities = 24/69 (34%), Positives = 33/69 (47%), Gaps = 3/69 (4%)
Query: 2499 KPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTS 2558
KPT K + ++S YT +S G +TL+I + DSG Y + TN G S
Sbjct: 26095 KPTAEVKWYHNGVELQESSKIHYTNTS---GVLTLEILDCHTDDSGTYRAVCTNYKGEAS 26151
Query: 2559 TSATVKVQG 2567
AT+ V G
Sbjct: 26152 DYATLDVTG 26160
Score = 35.4 bits (80), Expect = 0.85
Identities = 29/96 (30%), Positives = 41/96 (42%), Gaps = 7/96 (7%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIED 2631
P +P + + ++V L W P G I GY VE + W + +T + E+
Sbjct: 12888 PGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVR--CNTAPHQIPQEE 12945
Query: 2632 -----LSPGCPYQFRVSASNPWGISLPSEPSEFVRL 2662
L YQFR A IS PSEPS+ V +
Sbjct: 12946 YTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTI 12981
Score = 34.3 bits (77), Expect = 1.9
Identities = 16/26 (61%), Positives = 20/26 (76%)
Query: 2541 QDSGIYTCIATNDHGTTSTSATVKVQ 2566
+DSGI TC ATN +GT TSAT+ V+
Sbjct: 1724 RDSGIITCRATNKYGTDHTSATLIVK 1749
Score = 34.3 bits (77), Expect = 1.9
Identities = 37/147 (25%), Positives = 63/147 (42%), Gaps = 21/147 (14%)
Query: 2434 NKVSVKETN----SSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVI 2489
+K+ +KE S +++ +L +++L E P F V L D T + D +
Sbjct: 5323 HKLEMKEVTLDDISQIKAQVKELSSTAQLKVL------EADPYFTVKLHDKTAVEKDEIT 5376
Query: 2490 LQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
L+C+V + P +K ++ + S Y++ + D LKI +D G Y C
Sbjct: 5377 LKCEV-SKDVPVKWFKDGEEIV-----PSPKYSIKA-DGLRRILKIKKADLKDKGEYVC- 5428
Query: 2550 ATNDHGTTSTSATVKVQGVPAAPNRPI 2576
D GT T A V V+ +P+
Sbjct: 5429 ---DCGTDKTKANVTVEARLIKVEKPL 5452
Score = 33.5 bits (75), Expect = 3.2
Identities = 23/85 (27%), Positives = 39/85 (45%), Gaps = 6/85 (7%)
Query: 2485 GDTVILQCKVCGRPKPT-ITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDS 2543
G V CK+ + T +TW + + +++ TY + G L + ++ D
Sbjct: 25277 GGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITY-----EDGVAILYVKDITKLDD 25331
Query: 2544 GIYTCIATNDHGTTSTSATVKVQGV 2568
G Y C ND+G S+ A + V+GV
Sbjct: 25332 GTYRCKVVNDYGEDSSYAELFVKGV 25356
Score = 32.3 bits (72), Expect = 7.2
Identities = 34/154 (22%), Positives = 61/154 (39%), Gaps = 22/154 (14%)
Query: 2407 RMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFI 2466
R++ V++ + ++ P PK VS ET + + L + P
Sbjct: 26367 RVKSPEAVKSPKRVKSPEPSHPK-----AVSPTETKPTPTEKVQHLPVSAP-----PKIT 26416
Query: 2467 QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
Q + E + +TC++ +V+ R K +TW + + + + Y+
Sbjct: 26417 QFLKAEASKEIAKLTCVVESSVL-------RAKE-VTWYKDGKKLKENGHFQFHYSAD-- 26466
Query: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTS 2560
G LKI NL D G Y C + + GT+ T+
Sbjct: 26467 --GTYELKINNLTESDQGEYVCEISGEGGTSKTN 26498
>gi|110349713 titin isoform novex-1 [Homo sapiens]
Length = 27051
Score = 231 bits (588), Expect = 1e-59
Identities = 152/487 (31%), Positives = 240/487 (49%), Gaps = 26/487 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P+ L + V L G+ V ++ G+P P ITW+ Q+++D + S S
Sbjct: 24656 PKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQ-KGQDLIDNNGHYQVIVTRSFTS-- 24712
Query: 2531 ITLKICN-LMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRW 2589
L N + +D+G Y A N G + + V VP P + S SV L W
Sbjct: 24713 --LVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTW 24770
Query: 2590 LPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG 2649
P+S G I+ Y VE ++ W + V +T + +L YQFRV A N +G
Sbjct: 24771 TEPASDGGSKITNYIVEKCATTAERWLR-VGQARETRYTVINLFGKTSYQFRVIAENKFG 24829
Query: 2650 ISLPSEPSE-------FVRLPEYDAAAD---------GATISWKENFDSAYTELNEIGRG 2693
+S PSEPSE R YD D + S KE ++ Y ++GRG
Sbjct: 24830 LSKPSEPSEPTITKEDKTRAMNYDEEVDETREVSMTKASHSSTKELYEK-YMIAEDLGRG 24888
Query: 2694 RFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSY 2753
F IV +C+ +++K KFV K + E ++L +H + LH+++ES
Sbjct: 24889 EFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISILNIARHRNILHLHESFESMEEL 24948
Query: 2754 ILILELMDDGRLLDYLMNHD-ELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLID 2812
++I E + + + + EL E ++ Y+ + EALQ+LH+ + H DI+PEN++
Sbjct: 24949 VMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHFDIRPENIIYQ 25008
Query: 2813 LRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYV 2872
R +K+I+ A Q+ + L PE+ APEV Q VS TD+WS+G L YV
Sbjct: 25009 TRRS-STIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDMWSLGTLVYV 25067
Query: 2873 MLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATC 2932
+LSG++PFL E+ ++ N+ +++F E F +S A DF++ +L ++ + R TA+
Sbjct: 25068 LLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSRMTASEA 25127
Query: 2933 LQHPWLQ 2939
LQHPWL+
Sbjct: 25128 LQHPWLK 25134
Score = 101 bits (251), Expect = 1e-20
Identities = 68/214 (31%), Positives = 93/214 (43%), Gaps = 18/214 (8%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLM 2539
+TC G + + GRP P +TWK + + +TD S T T TL + + M
Sbjct: 22285 ITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTT-----KDRTTLTVKDSM 22339
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPI-AQERSCTSVILRWLPPSSTGNC 2598
DSG Y N G + S TV V G P PI S S +L W P G
Sbjct: 22340 RGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIEVSSVSAESCVLSWGEPKDGGGT 22399
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE--- 2655
I+ Y VE RE G+ WQ +S T + + L+ Y FRVS+ N +G+S P E
Sbjct: 22400 EITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAP 22459
Query: 2656 ---------PSEFVRLPEYDAAADGATISWKENF 2680
PS R Y +A+ +I W+E +
Sbjct: 22460 IIAEHPFVPPSAPTRPEVYHVSANAMSIRWEEPY 22493
Score = 97.4 bits (241), Expect = 2e-19
Identities = 68/211 (32%), Positives = 89/211 (42%), Gaps = 26/211 (12%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
GD + ++ V GRPKPT+TWK DQ + T + T +S L I + DSG
Sbjct: 14708 GDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATST-----ILNINECVRSDSG 14762
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTISGY 2603
Y A N G T++V +P P PI E S V W PP + G IS Y
Sbjct: 14763 PYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNY 14822
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI------------- 2650
VE R+ S W + + + T L+ G YQFRV A N +G+
Sbjct: 14823 VVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANY 14882
Query: 2651 --SLPSEPSEFVRLPEYDAAA-DGATISWKE 2678
+P P P+ A D TISW E
Sbjct: 14883 PFKVPGPPG----TPQVTAVTKDSMTISWHE 14909
Score = 94.4 bits (233), Expect = 2e-18
Identities = 59/186 (31%), Positives = 85/186 (45%), Gaps = 6/186 (3%)
Query: 2469 VAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDS 2528
+ P +P + G+ + ++ V GRP+P I+W + + T + T +S
Sbjct: 17938 IQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATST-- 17995
Query: 2529 GEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVIL 2587
L I D G YT ATN GT + + +V V P P P+ E S V++
Sbjct: 17996 ---VLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVI 18052
Query: 2588 RWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNP 2647
W PP+ TG C IS Y VE R+ + W A+ T + I L G YQFR+ A N
Sbjct: 18053 SWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENR 18112
Query: 2648 WGISLP 2653
+G S P
Sbjct: 18113 YGKSAP 18118
Score = 92.0 bits (227), Expect = 8e-18
Identities = 64/202 (31%), Positives = 91/202 (45%), Gaps = 17/202 (8%)
Query: 2487 TVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIY 2546
T+ L + GRP+P + W+ + + D T S L I N+ DSG Y
Sbjct: 18752 TLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVT-------SSFTMLVIDNVTRFDSGRY 18804
Query: 2547 TCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVE 2606
N+ G+ + V+V P+AP +E SV L W PP G I+ Y VE
Sbjct: 18805 NLTLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVE 18864
Query: 2607 YREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE-- 2664
RE + + + T IE+L GC Y FRV ASN +GI LP+E +E V++ E
Sbjct: 18865 KRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPP 18924
Query: 2665 --------YDAAADGATISWKE 2678
D + ATI W++
Sbjct: 18925 LPPGRVTLVDVTRNTATIKWEK 18946
Score = 91.7 bits (226), Expect = 1e-17
Identities = 61/196 (31%), Positives = 83/196 (42%), Gaps = 27/196 (13%)
Query: 2496 GRPKPTITWKGPDQNI-----LDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIA 2550
GRP PT W PD N+ + T +S +T TV +C+ D+G YT
Sbjct: 22011 GRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRN------------DAGKYTLTV 22058
Query: 2551 TNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREE 2610
N+ G+ S + TVKV P P ++ + S L W P G I Y VE RE
Sbjct: 22059 ENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKREA 22118
Query: 2611 GSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV---------- 2660
+ WQ + DL+ G PY FRVSA N +G+ P E E +
Sbjct: 22119 SRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPR 22178
Query: 2661 RLPEYDAAADGATISW 2676
RL D + A ++W
Sbjct: 22179 RLDVVDTSKSSAVLAW 22194
Score = 90.5 bits (223), Expect = 2e-17
Identities = 85/288 (29%), Positives = 125/288 (43%), Gaps = 34/288 (11%)
Query: 2414 VENTGKNEAT----GPRKPKDILGNKV---SVKETNSSEESECDDLDPNTSMEILNPNFI 2466
VE GK E T G K +I +++ SV E ++E DP T + P +
Sbjct: 21127 VERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVT----IGPITV 21182
Query: 2467 QE--VAPEFL---VPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATY 2521
+E + PE +P VT +G V L+ G+PKP+I+W + +++ +
Sbjct: 21183 KELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESE-----F 21237
Query: 2522 TVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QER 2580
S +ITL I N + G YT I N + TV G P+ P PI E
Sbjct: 21238 VRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKGPIRFDEI 21297
Query: 2581 SCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQF 2640
SVIL W P G I+ Y++E RE W+ +S T + +L YQF
Sbjct: 21298 KADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQF 21357
Query: 2641 RVSASNPWGISLPSEPSEFV-----RLPE-------YDAAADGATISW 2676
RV A N +G+S P S V R+P Y+ +DG +++W
Sbjct: 21358 RVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSLTW 21405
Score = 88.6 bits (218), Expect = 8e-17
Identities = 60/195 (30%), Positives = 85/195 (43%), Gaps = 9/195 (4%)
Query: 2468 EVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTD--NSSATYTVSS 2525
E+ P +P + + + GRP+ T+ W+ Q + +T N S++ TV+S
Sbjct: 19020 EIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTS 19079
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSV 2585
L I +D G Y +N G+ + T+ V P P E SC S+
Sbjct: 19080 -------LSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSI 19132
Query: 2586 ILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSAS 2645
+ W PP G C IS Y VE +E S W + T + I L+ G YQFRV A
Sbjct: 19133 TISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAE 19192
Query: 2646 NPWGISLPSEPSEFV 2660
N +G S SE S V
Sbjct: 19193 NRYGKSSYSESSAVV 19207
Score = 88.2 bits (217), Expect = 1e-16
Identities = 101/420 (24%), Positives = 157/420 (37%), Gaps = 60/420 (14%)
Query: 2422 ATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSM-EILNPNFIQEVAPEFLVPLVDV 2480
ATG + ++ N S SE D P T + E + P VA + L+
Sbjct: 12881 ATGLEEKAQYQFRAIARTAVNISPPSEPSD--PVTILAENVPPRIDLSVAMKSLL----- 12933
Query: 2481 TCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMP 2540
T G V L V G+P PT++WK + + + C TL++ ++
Sbjct: 12934 TVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLC-----TLELFSVNR 12988
Query: 2541 QDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTI 2600
+DSG YT A N G+ S + +KV P P + +L W PP G I
Sbjct: 12989 KDSGDYTITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEI 13048
Query: 2601 SGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
+ Y V+ RE W Q A+ T +E L G YQFR+ A N +G+ P +
Sbjct: 13049 TNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAI 13108
Query: 2661 RLPEYD------------AAADGATISWKENFDSA------------------YTELNEI 2690
YD D T+SWK D +T++N
Sbjct: 13109 AKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRK 13168
Query: 2691 GRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQH----PQYITLHDT 2746
++ + + T + V ++K K A +AA + Q+ P + ++DT
Sbjct: 13169 PIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDT 13228
Query: 2747 YESPTSYILILELMDDGR-LLDYLM-----NHDELME-------EKVAFYIRDIMEALQY 2793
S S D G ++ YL+ + D + +K F + +ME QY
Sbjct: 13229 TRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQY 13288
Score = 87.8 bits (216), Expect = 1e-16
Identities = 60/202 (29%), Positives = 88/202 (43%), Gaps = 17/202 (8%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G ++ L + GRP P + W D I D T + +S L + N+ DSG
Sbjct: 16585 GGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTS-------LVLDNVNRYDSG 16637
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
YT N GT S TV+V P+ P E + SV + W PP G I Y
Sbjct: 16638 KYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYI 16697
Query: 2605 VEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
VE RE + + V + I+ L GC Y FRV+A N +GI LP++ ++ +++ E
Sbjct: 16698 VEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAE 16757
Query: 2665 Y----------DAAADGATISW 2676
D + ++SW
Sbjct: 16758 VPQPPGKITVDDVTRNSVSLSW 16779
Score = 87.4 bits (215), Expect = 2e-16
Identities = 61/204 (29%), Positives = 89/204 (43%), Gaps = 21/204 (10%)
Query: 2487 TVILQCKVCGRPKPTITWKGPDQNILDTDN--SSATYTVSSCDSGEITLKICNLMPQDSG 2544
T+ L + GRP P + W LD + S+++YT+ L + N+ DSG
Sbjct: 15505 TLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTL---------LIVGNVNRFDSG 15555
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
Y N G+ S V+V P P +E + TSV L W PP G I Y
Sbjct: 15556 KYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYI 15615
Query: 2605 VEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
VE RE + + + T ++ L GC Y FRV A N +GI LP+E +E V+ E
Sbjct: 15616 VEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASE 15675
Query: 2665 ----------YDAAADGATISWKE 2678
D + ++SW++
Sbjct: 15676 RPLPPGKITLMDVTRNSVSLSWEK 15699
Score = 85.5 bits (210), Expect = 7e-16
Identities = 74/282 (26%), Positives = 117/282 (41%), Gaps = 36/282 (12%)
Query: 2453 DPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVC--------GRPKPTITW 2504
DP+ S + P +E E PL D+ + T+I++ GRP P + W
Sbjct: 19795 DPSDSSD---PQIAKEREEE---PLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLW 19848
Query: 2505 KGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVK 2564
PD TD + Y V + DS +L I N DSG YT N S + VK
Sbjct: 19849 SKPD-----TDLRTRAY-VDTTDS-RTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVK 19901
Query: 2565 VQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLD 2624
V P P Q+ + S +L W P + G + Y +E RE + W +
Sbjct: 19902 VLDTPGPPTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNR 19961
Query: 2625 TYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDA----------AADGATI 2674
+ +L G Y FRVS N +G+ +P+E E V++ E + + D ++
Sbjct: 19962 LSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSL 20021
Query: 2675 SW-KENFDS----AYTELNEIGRGRFSIVKKCIHKATRKDVA 2711
+W K D + + + +G+ + VK + K+T V+
Sbjct: 20022 TWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVS 20063
Score = 85.1 bits (209), Expect = 9e-16
Identities = 64/238 (26%), Positives = 100/238 (42%), Gaps = 10/238 (4%)
Query: 2484 LGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEIT-LKICNLMPQD 2542
+G + ++ + GRPKPTITW + T + T DS ++T L I D
Sbjct: 16871 VGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVT------DSLDLTTLSIKETHKDD 16924
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTIS 2601
G Y N G + S + P P P+ + S S+ L W PP TG C I+
Sbjct: 16925 GGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQIT 16984
Query: 2602 GYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV- 2660
Y V+ R+ + +W A+ T L + L G YQFR+ A N +G S E V
Sbjct: 16985 NYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVA 17044
Query: 2661 RLPEYDAAADGATISWKENFDSAYTELNE-IGRGRFSIVKKCIHKATRKDVAVKFVSK 2717
+ P + G + + DS + +E + G ++ + + R + V+K
Sbjct: 17045 QYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNK 17102
Score = 84.7 bits (208), Expect = 1e-15
Identities = 64/201 (31%), Positives = 84/201 (41%), Gaps = 15/201 (7%)
Query: 2485 GDTVILQCKVCGRPKPTITW-----KGPDQN--ILDTDNSSATYTVSSCDSGEITLKICN 2537
G V + K+ G P PT+TW K PD +L + + +C TL I
Sbjct: 9759 GTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTC-----TLVIPQ 9813
Query: 2538 LMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTSVILRWLPPSSTG 2596
D+G+YT A N+ GT S + V G P P PI E S + L W PP G
Sbjct: 9814 SRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDG 9873
Query: 2597 NCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP--S 2654
I+ Y +E RE + W + + I L G Y FR+ A N +GI P S
Sbjct: 9874 GSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDS 9933
Query: 2655 EPSEFVRLPEYDAAADGATIS 2675
EP L A D T+S
Sbjct: 9934 EPETARNLFSVPGAPDKPTVS 9954
Score = 84.0 bits (206), Expect = 2e-15
Identities = 54/171 (31%), Positives = 82/171 (47%), Gaps = 10/171 (5%)
Query: 2490 LQCKVCGRPKPTITWK-GPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTC 2548
L+ + G+P P+++WK G D DT S + V++ TL + + D+G YT
Sbjct: 13630 LKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNT------TLIVYDCQKSDAGKYTI 13683
Query: 2549 IATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTISGYTVEY 2607
N GT + ++KV G P P PI E + ++ L+W PP G I+ Y +E
Sbjct: 13684 TLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEK 13743
Query: 2608 REEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI--SLPSEP 2656
R+ + W ++ T + L G Y FRVSA N +G+ L SEP
Sbjct: 13744 RDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEP 13794
Score = 84.0 bits (206), Expect = 2e-15
Identities = 77/295 (26%), Positives = 119/295 (40%), Gaps = 24/295 (8%)
Query: 2398 KKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTS 2457
K S W T K E TG I G + S + + +E+ D S
Sbjct: 15718 KGSDKWATCATVKVTEATITGL-----------IQGEEYSFRVSAQNEKGISDPRQ--LS 15764
Query: 2458 MEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNS 2517
+ ++ + + + P F + T L G+ + + GRP P +TW + + T
Sbjct: 15765 VPVIAKDLV--IPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRV 15822
Query: 2518 SATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA 2577
+A T ++ L I + +D G Y TN G + V V P P P+
Sbjct: 15823 NAESTENNS-----LLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVK 15877
Query: 2578 QER-SCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGC 2636
+ + S+ L W PP G +I+ Y VE R+ + WQ A+ T + L GC
Sbjct: 15878 MDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGC 15937
Query: 2637 PYQFRVSASNPWGIS--LPSEPSEFVRLPEYDAAADGATISWKENFDSAYTELNE 2689
YQFR++A N +G S L SEP+ + P G + + DS + NE
Sbjct: 15938 EYQFRIAAENRYGKSTYLNSEPT-VAQYPFKVPGPPGTPVVTLSSRDSMEVQWNE 15991
Score = 83.6 bits (205), Expect = 3e-15
Identities = 64/209 (30%), Positives = 93/209 (44%), Gaps = 17/209 (8%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G+ V + GRP PT+TW+ ++N+ S A Y++ + DS + L I + D+G
Sbjct: 20914 GEDVQVLIPFKGRPPPTVTWRKDEKNL----GSDARYSIENTDSSSL-LTIPQVTRNDTG 20968
Query: 2545 IYTCIATNDHGTT-STSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
Y N G S++ +VKV PAA + + S +V L W PP G I Y
Sbjct: 20969 KYILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINY 21028
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLP 2663
+E R+ + W T + DLS P+ FRV A N GI P E +E V+
Sbjct: 21029 VIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAA 21088
Query: 2664 EY----------DAAADGATISW-KENFD 2681
E D+ +SW K +FD
Sbjct: 21089 EVPAPIRDLSMKDSTKTSVILSWTKPDFD 21117
Score = 83.2 bits (204), Expect = 4e-15
Identities = 65/227 (28%), Positives = 90/227 (39%), Gaps = 20/227 (8%)
Query: 2470 APEFLVP---LVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
APE + L +T G + L V G+P+P ITW D IL D V
Sbjct: 7315 APEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADM-ILKQDKRITIENVPK- 7372
Query: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVI 2586
+ T+ I + D+G Y A N G + V V P P + + S +
Sbjct: 7373 ---KSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCL 7429
Query: 2587 LRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASN 2646
L W PP G I+ Y VE R S++W + ++ DT L P Y FRV+A N
Sbjct: 7430 LTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAEN 7489
Query: 2647 PWGISLPSE------------PSEFVRLPEYDAAADGATISWKENFD 2681
+G+ P + P RL D D T++W E D
Sbjct: 7490 MYGVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDD 7536
Score = 82.8 bits (203), Expect = 5e-15
Identities = 67/221 (30%), Positives = 91/221 (41%), Gaps = 18/221 (8%)
Query: 2480 VTCLLGDTVILQC-KVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNL 2538
+T GDT++L + G+P P +W ++I +D + T T +S +T+K
Sbjct: 14016 LTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS---SMLTIKYATR 14072
Query: 2539 MPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNC 2598
+D+G YT ATN GT V V VP P S L W PP G
Sbjct: 14073 --KDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGS 14130
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP--SEP 2656
I Y +E RE +W V L G Y FRVSA N +G P SEP
Sbjct: 14131 PIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEP 14190
Query: 2657 SEFV---------RLPEY-DAAADGATISWKENFDSAYTEL 2687
+ V PE + + AT+SWK D +E+
Sbjct: 14191 VKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEI 14231
Score = 82.4 bits (202), Expect = 6e-15
Identities = 57/234 (24%), Positives = 101/234 (43%), Gaps = 18/234 (7%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLM 2539
+T +G+ L + G+PKP ++W + ++L+ D + T ++ +I K
Sbjct: 10456 LTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAK----- 10510
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNC 2598
DSG Y + N G+ V V P P P++ E + +++ W PP G
Sbjct: 10511 RSDSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVTKDYMVISWKPPLDDGGS 10570
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP----- 2653
I+ Y +E +E G +W +++ T + L G Y FR+ A N +GIS P
Sbjct: 10571 KITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDS 10630
Query: 2654 SEPSEFVRLPE-------YDAAADGATISWKENFDSAYTELNEIGRGRFSIVKK 2700
+ + R+P+ + D A ++W + D N I R ++ K+
Sbjct: 10631 MKAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKPITNYILEKRETMSKR 10684
Score = 80.5 bits (197), Expect = 2e-14
Identities = 60/199 (30%), Positives = 88/199 (44%), Gaps = 8/199 (4%)
Query: 2467 QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
Q + P+ L+P +T G + ++ V G+P PT WK + ++ +S+ V
Sbjct: 12524 QLLPPKILMP-EQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVV----TSSHLAVHKA 12578
Query: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPI-AQERSCTSV 2585
DS I L I ++ +DSG Y+ A N GT + V V P P P + +
Sbjct: 12579 DSSSI-LIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADAC 12637
Query: 2586 ILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSAS 2645
L W P G I+ Y VE + W ++AS T + L PG Y FRV A
Sbjct: 12638 SLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAE 12697
Query: 2646 NPWGISLP-SEPSEFVRLP 2663
N +GIS P + P + P
Sbjct: 12698 NRFGISEPLTSPKMVAQFP 12716
Score = 78.2 bits (191), Expect = 1e-13
Identities = 63/207 (30%), Positives = 92/207 (44%), Gaps = 22/207 (10%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSA-TYT-VSSCDSGEITLKICNLMPQD 2542
G V L + GRP P +W + +++ + T+T V+ E T++ D
Sbjct: 23381 GRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIR-------D 23433
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTIS 2601
+G YT N GTTS + V + P P PI E TS+ + W PP G +S
Sbjct: 23434 TGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLS 23493
Query: 2602 GYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGIS--LPSEPSE- 2658
GY VE R+ W S + L+ G Y FRV+A+N +GI L SE E
Sbjct: 23494 GYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIEC 23553
Query: 2659 --FVRLPE-------YDAAADGATISW 2676
+R+P +D + DG T++W
Sbjct: 23554 RSSIRIPGPPETLQIFDVSRDGMTLTW 23580
Score = 77.0 bits (188), Expect = 3e-13
Identities = 59/204 (28%), Positives = 79/204 (38%), Gaps = 15/204 (7%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G T+ L V GRP P ITW P+ N+ D + S D + L+ N+ D+G
Sbjct: 13336 GVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLD----IKSTDF-DTFLRCENVNKYDAG 13390
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
Y N G + VKV P P +E S S + W PP G I Y
Sbjct: 13391 KYILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYV 13450
Query: 2605 VEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE--------- 2655
V+ R+ + W T + +L G Y FRV A N +GI P E
Sbjct: 13451 VQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQ 13510
Query: 2656 -PSEFVRLPEYDAAADGATISWKE 2678
P V L + +I WK+
Sbjct: 13511 TPGPVVDLKVRSVSKSSCSIGWKK 13534
Score = 77.0 bits (188), Expect = 3e-13
Identities = 61/216 (28%), Positives = 85/216 (39%), Gaps = 17/216 (7%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G+T +L+ + G+P P + W + + +T +A + S + TL + + + D G
Sbjct: 18350 GETFVLEADIRGKPIPDVVWSKDGKELEET---AARMEIKSTIQ-KTTLVVKDCIRTDGG 18405
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTSVILRWLPPSSTGNCTISGY 2603
Y +N GT S TVKV P P P+ + L W PP G IS Y
Sbjct: 18406 QYILKLSNVGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHY 18465
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE-------- 2655
+E RE W Q + L PG Y FRV A N +GI P E
Sbjct: 18466 IIEKRETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACN 18525
Query: 2656 ---PSEFVRLPEYDA-AADGATISWKENFDSAYTEL 2687
P PE A D ++W D TE+
Sbjct: 18526 PYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEI 18561
Score = 76.3 bits (186), Expect = 4e-13
Identities = 54/187 (28%), Positives = 74/187 (39%), Gaps = 3/187 (1%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLM 2539
+T GDT+ L+ V G+P P + W D++ D S + DS + +L
Sbjct: 11839 LTVKAGDTIRLEAGVRGKPFPEVAWT-KDKDATDLTRSPRVKIDTRADSSKFSLT--KAK 11895
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCT 2599
D G Y ATN G+ ATV V P + S + W PP G C
Sbjct: 11896 RSDGGKYVVTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWDPPEDDGGCE 11955
Query: 2600 ISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF 2659
I Y +E E +W A+ L + L G Y FRV A N G P+E
Sbjct: 11956 IQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTESKPV 12015
Query: 2660 VRLPEYD 2666
+ +YD
Sbjct: 12016 IAKTKYD 12022
Score = 75.9 bits (185), Expect = 6e-13
Identities = 60/199 (30%), Positives = 78/199 (39%), Gaps = 14/199 (7%)
Query: 2476 PLVDVTCLLGDTVIL--------QCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCD 2527
P + V DTVIL + V GRP PT+ W + + T A + D
Sbjct: 15087 PKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGT----AKLEIKIAD 15142
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVI 2586
L + +DSG YT ATN G VKV P P P+A E + +
Sbjct: 15143 FST-NLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEKCV 15201
Query: 2587 LRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASN 2646
L W PP G I Y V+ RE W + T L + L G Y FRV A N
Sbjct: 15202 LSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVN 15261
Query: 2647 PWGISLPSEPSEFVRLPEY 2665
+G+ P E + + Y
Sbjct: 15262 KYGVGEPLESEPVLAVNPY 15280
Score = 75.9 bits (185), Expect = 6e-13
Identities = 53/195 (27%), Positives = 76/195 (38%), Gaps = 21/195 (10%)
Query: 2496 GRPKPTITWKGPDQNILDTDN--SSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATND 2553
GRP P ITW + D YT S D N D+G Y N
Sbjct: 17678 GRPTPEITWSREEGEFTDKVQIEKGVNYTQLSID---------NCDRNDAGKYILKLENS 17728
Query: 2554 HGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQ 2613
G+ S TVKV P P +E S L W PP G + Y ++ RE +
Sbjct: 17729 SGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRK 17788
Query: 2614 IWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE--------- 2664
+ + T +E+L+ G Y FRV A N +G+ +P E + V+ E
Sbjct: 17789 AYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVT 17848
Query: 2665 -YDAAADGATISWKE 2678
D + A++ W++
Sbjct: 17849 LTDVSQTSASLMWEK 17863
Score = 75.5 bits (184), Expect = 7e-13
Identities = 52/180 (28%), Positives = 73/180 (40%), Gaps = 18/180 (10%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNI-----LDTDNSSATYTVSSCDSGEITLKICNLM 2539
G + L + G+P P W Q+I + T + + D G
Sbjct: 23779 GGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRG---------- 23828
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTSVILRWLPPSSTGNC 2598
DSG Y + N G + V+V G P +P P+ + SV + W PP+ G
Sbjct: 23829 --DSGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGA 23886
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
I GY +E RE W + T LV++ L Y FRVSA N +GIS P + E
Sbjct: 23887 DILGYILERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEE 23946
Score = 75.1 bits (183), Expect = 1e-12
Identities = 63/237 (26%), Positives = 100/237 (42%), Gaps = 19/237 (8%)
Query: 2454 PNTSMEILNPNFIQEVAPEFLVPLVD-VTCLLGDTVILQCKVCGRPKPTITWKGPDQNIL 2512
P+T++ I + + E V L++ + G TV + G P PT W D + +
Sbjct: 11121 PDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWT-TDGSEI 11179
Query: 2513 DTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAP 2572
TD YTV + D+ L I N + +D+G Y +N G+ + + + V VP P
Sbjct: 11180 KTDEH---YTVET-DNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPP 11235
Query: 2573 NRPI-AQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIED 2631
PI + + + + W PP G + Y VE ++ W + + T L I
Sbjct: 11236 TGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPH 11295
Query: 2632 LSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEY------------DAAADGATISW 2676
L GC Y FRV A N G+ P + + V ++ D + AT+SW
Sbjct: 11296 LQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSW 11352
Score = 74.3 bits (181), Expect = 2e-12
Identities = 62/214 (28%), Positives = 86/214 (40%), Gaps = 27/214 (12%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITW--KGPD---QNILDTDNSSATYTVSSCDSGEITLK 2534
VT G ++ L V GRP P ITW +G D + I+DT S + V +
Sbjct: 23084 VTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNR------ 23137
Query: 2535 ICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSS 2594
D+G YT A N G S + VKV P +E S SV + W P+
Sbjct: 23138 ------YDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTI 23191
Query: 2595 TGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPS 2654
G ++ Y VE RE + ++ T I L G Y FRV N +GI P
Sbjct: 23192 DGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPC 23251
Query: 2655 EPSEFV----------RLPEYDAAADGATISWKE 2678
E S+ V +L D T++W++
Sbjct: 23252 ETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEK 23285
Score = 73.9 bits (180), Expect = 2e-12
Identities = 61/206 (29%), Positives = 83/206 (40%), Gaps = 20/206 (9%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G+T L+ V G+P PTI W D+ I SA + + D + + + + + D G
Sbjct: 17268 GETFRLEADVHGKPLPTIEWLRGDKEI----EESARCEIKNTDFKALLI-VKDAIRIDGG 17322
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTS--VILRWLPPSSTGNCTISG 2602
Y A+N G+ S VKV P P P+ Q TS L W PP G IS
Sbjct: 17323 QYILRASNVAGSKSFPVNVKVLDRPGPPEGPV-QVTGVTSEKCSLTWSPPLQDGGSDISH 17381
Query: 2603 YTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE------- 2655
Y VE RE W + + L + L G Y FR+ A N +G+ P E
Sbjct: 17382 YVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMK 17441
Query: 2656 -----PSEFVRLPEYDAAADGATISW 2676
P L + A D T+ W
Sbjct: 17442 NPFVLPGPPKSLEVTNIAKDSMTVCW 17467
Score = 73.6 bits (179), Expect = 3e-12
Identities = 61/271 (22%), Positives = 100/271 (36%), Gaps = 46/271 (16%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNS-------------------------SA 2519
GD + L + G P PTITW D+N++ + +
Sbjct: 8322 GDEIALDASISGSPYPTITWI-KDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQ 8380
Query: 2520 TYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQE 2579
++ + GE L++ + + D G+Y NDHG TV V P P + ++
Sbjct: 8381 RLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPINFVFED 8440
Query: 2580 RSCTSVILRWLPPSSTGNCTISGYTVEYRE--EGSQIWQQSVASTLDTYLVIEDLSPGCP 2637
TSV+ +W PP G I YT+E ++ + W ++ + L G
Sbjct: 8441 IRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKE 8500
Query: 2638 YQFRVSASNPWGISLPSEPSEFVRLPEY------------DAAADGATISWKENFDSA-- 2683
Y FRV A N +G P V + D ++ + W E D+
Sbjct: 8501 YLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNGSP 8560
Query: 2684 ----YTELNEIGRGRFSIVKKCIHKATRKDV 2710
+ E E+ +S V K + A + +V
Sbjct: 8561 ILGYWLEKREVNSTHWSRVNKSLLNALKANV 8591
Score = 72.8 bits (177), Expect = 5e-12
Identities = 64/221 (28%), Positives = 95/221 (42%), Gaps = 21/221 (9%)
Query: 2444 SEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTC-------LLGDTVILQCKVCG 2496
S E++ DP+ EIL P + F+ P +D++ ++ + + + G
Sbjct: 6995 SAENKAGVSDPS---EILGPLTADDA---FVEPTMDLSAFKDGLEVIVPNPITILVPSTG 7048
Query: 2497 RPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT 2556
P+PT TW D+ +L+T + T+S+ L I D GIYT N T
Sbjct: 7049 YPRPTATWCFGDK-VLETGDRVKMKTLSAYAE----LVISPSERSDKGIYTLKLENRVKT 7103
Query: 2557 TSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQ 2616
S V V P+AP + + SV L W PP G ++GY VE RE + W
Sbjct: 7104 ISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWT 7163
Query: 2617 QSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPS 2657
+ + D + DL G Y F+V A N G P EP+
Sbjct: 7164 KVMDFVTDLEFTVPDLVQGKEYLFKVCARNKCG---PGEPA 7201
Score = 72.8 bits (177), Expect = 5e-12
Identities = 54/180 (30%), Positives = 74/180 (41%), Gaps = 12/180 (6%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G++ + + G+P PTI W DQ + +T A + S D +L + + + DSG
Sbjct: 16186 GESFKVDADIYGKPIPTIQWIKGDQELSNT----ARLEIKSTDFAT-SLSVKDAVRVDSG 16240
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA----QERSCTSVILRWLPPSSTGNCTI 2600
Y A N G S + VKV P P P+ CT L W PP G I
Sbjct: 16241 NYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCT---LAWKPPLQDGGSDI 16297
Query: 2601 SGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
Y VE RE +W A+ + L G Y FR+ A N +G+ P E V
Sbjct: 16298 INYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVV 16357
Score = 72.0 bits (175), Expect = 8e-12
Identities = 44/168 (26%), Positives = 74/168 (44%), Gaps = 6/168 (3%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G + + + G+P P +T + T + T + +T+ + + D+G
Sbjct: 20119 GSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAEN-----LTINLKESVTADAG 20173
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTISGY 2603
Y A N GTT + V P P P+ + + SV L+W PP G ++ Y
Sbjct: 20174 RYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNY 20233
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGIS 2651
+ RE + +W + A+ T + + L+ G YQFR+ A N +GIS
Sbjct: 20234 ILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAENRFGIS 20281
Score = 71.6 bits (174), Expect = 1e-11
Identities = 63/231 (27%), Positives = 91/231 (39%), Gaps = 23/231 (9%)
Query: 2459 EILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSS 2518
EIL P I A + +V C + L V GRP P +TW+ + DN
Sbjct: 12227 EILEPPEIDLDASMRKLVIVRAGC----PIRLFAIVRGRPAPKVTWRK-----VGIDNVV 12277
Query: 2519 ATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQ 2578
V D+ L I N DSG Y+ N G + V+V P +
Sbjct: 12278 RKGQVDLVDTMAF-LVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVS 12336
Query: 2579 ERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPY 2638
+ + TS + W PP + G ++ Y VE RE + W T + +L PG Y
Sbjct: 12337 DVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEY 12396
Query: 2639 QFRVSASNPWGISLP-------------SEPSEFVRLPEYDAAADGATISW 2676
FRV+A N +G +P SEP +L + + AT++W
Sbjct: 12397 YFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAW 12447
Score = 71.6 bits (174), Expect = 1e-11
Identities = 48/177 (27%), Positives = 76/177 (42%), Gaps = 6/177 (3%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G +V L+ + G+P PTI W D+ + ++ ++ D I +K + + +SG
Sbjct: 20515 GTSVKLRAGISGKPAPTIEWYKDDKEL---QTNALVCVENTTDLASILIKDADRL--NSG 20569
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTSVILRWLPPSSTGNCTISGY 2603
Y N G+ S + V++ P P PI + + + L W PP+ G I+ Y
Sbjct: 20570 CYELKLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHY 20629
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
VE RE +W + + + G Y FRV A N +GI P E V
Sbjct: 20630 IVEKRETSRVVWSMVSEHLEECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVV 20686
Score = 71.2 bits (173), Expect = 1e-11
Identities = 67/221 (30%), Positives = 97/221 (43%), Gaps = 29/221 (13%)
Query: 2364 PASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHTLR---MRKRAE------- 2413
P ++H A + GS +A L K +A SS I KS T++ R RAE
Sbjct: 778 PKTEHGYEAS--IAGSAIATLQKELSATSSAQKITKSVKAPTVKPSETRVRAEPTPLPQF 835
Query: 2414 ----VENTGKNEATGPRKPKDILGNKVSVKETNSSEES----ECDDLDPNTSMEILNPNF 2465
+T K+EA G K++ VS+ T EE + + + P
Sbjct: 836 PFADTPDTYKSEA-GVEVKKEV---GVSITGTTVREERFEVLHGREAKVTETARVPAPVE 891
Query: 2466 IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSS 2525
I P + L +VT + G++V L+C + G P PT+TW D I + + T+
Sbjct: 892 IPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF---- 947
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
SG L I +DSG +TC A N+ GT STS + VQ
Sbjct: 948 -QSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 987
Score = 70.9 bits (172), Expect = 2e-11
Identities = 50/166 (30%), Positives = 69/166 (41%), Gaps = 7/166 (4%)
Query: 2484 LGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDS 2543
+GDT+ L + G P P +TWK D++ T S L+I N +D
Sbjct: 10860 VGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSK-------LEIRNAAHEDG 10912
Query: 2544 GIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
GIY+ N G+ + S V V P P E S L W P G I+ Y
Sbjct: 10913 GIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNY 10972
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG 2649
VE R+ S W A++ + L+ G Y FRV+A N +G
Sbjct: 10973 VVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYG 11018
Score = 70.5 bits (171), Expect = 2e-11
Identities = 61/253 (24%), Positives = 104/253 (41%), Gaps = 24/253 (9%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G + + V G+P PT+TW ++ L + + T +SS ++ I N G
Sbjct: 10167 GGVIRIIAYVSGKPPPTVTWN-MNERTLPQEATIETTAISS------SMVIKNCQRSHQG 10219
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRP-IAQERSCTSVILRWLPPSSTGNCTISGY 2603
+Y+ +A N+ G + V V VP P +A + S L W P G I+ Y
Sbjct: 10220 VYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNY 10279
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF---- 2659
+E RE + W + ++ L G Y FR++A N G+ E SE
Sbjct: 10280 VIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIR 10339
Query: 2660 --VRLPE-------YDAAADGATISWK-ENFDSAYTELNEIGRGRFSIVKKCIHKATRKD 2709
+ +PE + + T++W +D +N + R +K HK T +
Sbjct: 10340 EPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEK-FHKVTNDN 10398
Query: 2710 -VAVKFVSKKMKK 2721
++ K+ K +K+
Sbjct: 10399 LLSRKYTVKGLKE 10411
Score = 68.9 bits (167), Expect = 7e-11
Identities = 63/245 (25%), Positives = 94/245 (38%), Gaps = 36/245 (14%)
Query: 2429 KDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLL---G 2485
K++ + VK N + ESE D T+ EI + +E PE + + CL+ G
Sbjct: 9400 KELRKYRFRVKAVNEAGESEPSD----TTGEIPATDIQEE--PEVFIDIGAQDCLVCKAG 9453
Query: 2486 DTVILQCKVCGRPKPTITWKG---------------PDQNILDTDNSSATYTVSSCDSGE 2530
+ + + GRP P +W+ P+ L+T +S+ + C
Sbjct: 9454 SQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSH 9513
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWL 2590
+G Y+ A N G + + VKV VP P + + S L W
Sbjct: 9514 ------------TGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWK 9561
Query: 2591 PPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI 2650
P G I GY +E R + W + T V+ DL Y FRV A N +GI
Sbjct: 9562 MPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGI 9621
Query: 2651 SLPSE 2655
P E
Sbjct: 9622 GPPVE 9626
Score = 68.6 bits (166), Expect = 9e-11
Identities = 56/181 (30%), Positives = 83/181 (45%), Gaps = 10/181 (5%)
Query: 2484 LGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQD- 2542
+G T+ L GRP P +TW + + +++N + T L + N+ +
Sbjct: 24270 VGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTH-----LVMKNVQRKTH 24324
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSC-TSVILRWLPPSSTGNCTIS 2601
+G Y +N GT V++Q P P PI E S ++ W PP+ G I+
Sbjct: 24325 AGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWIT 24384
Query: 2602 GYTVEYRE--EGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF 2659
Y VE E EG++ WQ ++ T I +L+ Y FRVSA N +GIS P E S
Sbjct: 24385 NYVVEKCEAKEGAE-WQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSV 24443
Query: 2660 V 2660
V
Sbjct: 24444 V 24444
Score = 68.2 bits (165), Expect = 1e-10
Identities = 44/153 (28%), Positives = 70/153 (45%), Gaps = 6/153 (3%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGV-----P 2569
+ S ++T S + + K+ L+P + I+ +A N +G + V P
Sbjct: 18471 ETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPP 18530
Query: 2570 AAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLV 2628
P+ P + S+++ W P G I GY +E R++ W + TL D L
Sbjct: 18531 GPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLR 18590
Query: 2629 IEDLSPGCPYQFRVSASNPWGISLPSEPSEFVR 2661
+ L+ G Y+FRV+A N G+ PSEPS F R
Sbjct: 18591 VTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYR 18623
Score = 67.8 bits (164), Expect = 2e-10
Identities = 67/259 (25%), Positives = 106/259 (40%), Gaps = 29/259 (11%)
Query: 2435 KVSVKETNSSEESECDDLDPNTSMEILNPNFIQ-EVAPEFLVPLVDVTCLLGDTVILQCK 2493
K+ V N++ E + P T E P ++ +V+ + + + + G T+ +
Sbjct: 8701 KLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQI-----MAGKTLRIPAV 8755
Query: 2494 VCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATND 2553
V GRP PT W ++ LD D V + L I + + +D G Y ATN
Sbjct: 8756 VTGRPVPTKVWT-KEEGELDKDR-----VVIDNVGTKSELIIKDALRKDHGRYVITATNS 8809
Query: 2554 HGTTSTSATVKVQGV--PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEG 2611
G+ +A V+V V P +P+ R +L W P G I+G+ +E ++
Sbjct: 8810 CGSKFAAARVEVFDVPGPVLDLKPVVTNRK--MCLLNWSDPEDDGGSEITGFIIERKDAK 8867
Query: 2612 SQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE------------PSEF 2659
W+Q + T + I L G Y+FRV A N +G P E P+
Sbjct: 8868 MHTWRQPI-ETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSP 8926
Query: 2660 VRLPEYDAAADGATISWKE 2678
RL + T+ WKE
Sbjct: 8927 ERLTYTERTKSTITLDWKE 8945
Score = 67.8 bits (164), Expect = 2e-10
Identities = 51/205 (24%), Positives = 85/205 (41%), Gaps = 30/205 (14%)
Query: 2487 TVILQCKVCGRPKP---------------TITWKGPDQN---------ILDTDNSSATYT 2522
+V + CKV +P P +++W P ++ + + S +T
Sbjct: 19500 SVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWT 19559
Query: 2523 VSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG-----VPAAPNRPIA 2577
+ + + K+ L+ + I+ N +G +V ++ VP+ P
Sbjct: 19560 ICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEI 19619
Query: 2578 QERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGC 2636
+ S+ L W P S G ISGY +E RE+ S W + + D + L GC
Sbjct: 19620 TSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGC 19679
Query: 2637 PYQFRVSASNPWGISLPSEPSEFVR 2661
Y++RV A N G+SLPSE S +R
Sbjct: 19680 EYEYRVYAENAAGLSLPSETSPLIR 19704
Score = 67.4 bits (163), Expect = 2e-10
Identities = 52/181 (28%), Positives = 69/181 (38%), Gaps = 5/181 (2%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLM 2539
VT G ++L V G+P+P I W D+ + + S YT + +K C+
Sbjct: 22685 VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATA---VIKFCDR- 22740
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCT 2599
DSG YT N GT + S VKV P + + L W P G
Sbjct: 22741 -SDSGKYTLTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAE 22799
Query: 2600 ISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF 2659
I+ Y VE RE W V+ L Y FRV A N +G +P E
Sbjct: 22800 ITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPI 22859
Query: 2660 V 2660
V
Sbjct: 22860 V 22860
Score = 66.6 bits (161), Expect = 3e-10
Identities = 56/211 (26%), Positives = 88/211 (41%), Gaps = 10/211 (4%)
Query: 2467 QEVAPEFLVPLVDVTCLL---GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTV 2523
+E+AP+F + L+ G ++ + + GRP P +TW + N+ + N T +
Sbjct: 14398 REMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESF 14457
Query: 2524 SSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCT 2583
+ + + CN D+G + N G S V+V P + +
Sbjct: 14458 TL-----LIIPECNRY--DTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKD 14510
Query: 2584 SVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVS 2643
SV L W P G I+ Y VE RE + + + + LS GC Y FRV
Sbjct: 14511 SVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVM 14570
Query: 2644 ASNPWGISLPSEPSEFVRLPEYDAAADGATI 2674
A N +GI P+E +E V+ E + D I
Sbjct: 14571 AENEYGIGEPTETTEPVKASEAPSPPDSLNI 14601
Score = 65.9 bits (159), Expect = 6e-10
Identities = 55/212 (25%), Positives = 90/212 (42%), Gaps = 18/212 (8%)
Query: 2479 DVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNL 2538
D+ + G+ + + P PT++W + + +D + D L++
Sbjct: 8023 DIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKN-----DHISAHLEVPKS 8077
Query: 2539 MPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNC 2598
+ D+GIYT N G+ + S VKV G+P A + + +S L W PP G
Sbjct: 8078 VRADAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGT 8137
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG----ISL-- 2652
I Y +E RE G + + ++ ++DL P Y FRV A N G I L
Sbjct: 8138 PILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKN 8197
Query: 2653 ------PSEPSE-FVRLPEYDAAADGATISWK 2677
P +P + V + ++ A+ TI+WK
Sbjct: 8198 PVIAQDPKQPPDPPVDVEVHNPTAEAMTITWK 8229
Score = 65.5 bits (158), Expect = 8e-10
Identities = 46/138 (33%), Positives = 68/138 (49%), Gaps = 8/138 (5%)
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTS--TSATVKVQG---VPAAPNRPIAQERSC 2582
S + T K+ L+ I+ A N +G + S ++K + VP AP++PI E +
Sbjct: 10594 SAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTK 10653
Query: 2583 TSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLV--IEDLSPGCPYQF 2640
S ++ W P G I+ Y +E RE S+ W + + Y + DL GC Y+F
Sbjct: 10654 DSALVTWNKPHDGGK-PITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEF 10712
Query: 2641 RVSASNPWGISLPSEPSE 2658
RVSA N GI PS PS+
Sbjct: 10713 RVSAENEIGIGDPSPPSK 10730
Score = 65.5 bits (158), Expect = 8e-10
Identities = 46/173 (26%), Positives = 76/173 (43%), Gaps = 15/173 (8%)
Query: 2501 TITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIAT 2551
T+ W+ P + +L + S+A +T S +K+ L + + A
Sbjct: 20216 TLKWEPPKYDGGSQVTNYILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAE 20275
Query: 2552 NDHGTT----STSATVKVQ-GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVE 2606
N G + S TVK+ P P+ P + S+ + W P S G + GY +E
Sbjct: 20276 NRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSAVVGYHLE 20335
Query: 2607 YREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
++ S +WQ++ + T+ + +S G Y+FRV A N G+ PS PSE
Sbjct: 20336 MKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSHPSE 20388
Score = 65.1 bits (157), Expect = 1e-09
Identities = 46/171 (26%), Positives = 74/171 (43%), Gaps = 5/171 (2%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILD--TDNSSATYTVSSCDSGEITLKICNLMPQD 2542
G+ V + V G P P I W ++ +++ TD T S + L I + +D
Sbjct: 9041 GEPVHIPADVTGLPMPKIEWS-KNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVRED 9099
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISG 2602
G YT A+N G+ + V+V P+ P + S L W P G I+
Sbjct: 9100 KGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAPLDNGGSEITH 9159
Query: 2603 YTVEYREEGSQ--IWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGIS 2651
Y ++ R+ + W++ + ++ I L P Y+FRV A N +GIS
Sbjct: 9160 YVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGIS 9210
Score = 64.7 bits (156), Expect = 1e-09
Identities = 53/183 (28%), Positives = 75/183 (40%), Gaps = 30/183 (16%)
Query: 2502 ITWKGPDQNILDTDNSSAT-YTVSSCDSG-------EIT-------LKICNLMPQDSGIY 2546
+TW P LD S T Y + D+ E+T I L+P +
Sbjct: 9144 LTWDAP----LDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEF 9199
Query: 2547 TCIATNDHGTTSTSATVKV-----QGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTIS 2601
A N +G + + KV +P P +P R+ S+++ W PP G I+
Sbjct: 9200 RVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPIT 9259
Query: 2602 GYTVEYREEGSQIWQQSVASTL------DTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
GY +E REEGS W + + + + L G YQFR A N GI PSE
Sbjct: 9260 GYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSE 9319
Query: 2656 PSE 2658
PS+
Sbjct: 9320 PSD 9322
Score = 64.7 bits (156), Expect = 1e-09
Identities = 31/91 (34%), Positives = 49/91 (53%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYL 2627
+P+ P++P + T++ + W+ P G I+GYTVEY++ W+ S+ S T
Sbjct: 19711 LPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEY 19770
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
I L+ G Y FRV + N G S PS+ S+
Sbjct: 19771 TISGLTTGAEYVFRVKSVNKVGASDPSDSSD 19801
Score = 64.3 bits (155), Expect = 2e-09
Identities = 36/108 (33%), Positives = 54/108 (50%), Gaps = 1/108 (0%)
Query: 2558 STSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ 2617
S AT + P P P + + +S L W PP G ++GY VEY+EEG + W++
Sbjct: 10038 SDPATARDPIAPPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEK 10097
Query: 2618 SVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
+ T LV+ L G Y+FRV A N GI P E ++ + + +
Sbjct: 10098 GKDKEVRGTKLVVTGLKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKD 10145
Score = 64.3 bits (155), Expect = 2e-09
Identities = 46/172 (26%), Positives = 72/172 (41%), Gaps = 6/172 (3%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G+ + + + GRP P I+W ++ ++ + + T +S+ + +T+K C + +D+G
Sbjct: 19432 GEVLKINADIAGRPLPVISWA---KDGIEIEERARTEIISTDNHTLLTVKDC--IRRDTG 19486
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPI-AQERSCTSVILRWLPPSSTGNCTISGY 2603
Y N GT S + KV P P P+ + L W P G I Y
Sbjct: 19487 QYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYY 19546
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
VE RE W T + L G Y FRV+ N +G+ P E
Sbjct: 19547 IVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLE 19598
Score = 63.5 bits (153), Expect = 3e-09
Identities = 68/267 (25%), Positives = 107/267 (40%), Gaps = 32/267 (11%)
Query: 2466 IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSS 2525
I E PE+ L+ + G+++ ++ V GRP P +TW I N T +
Sbjct: 21585 IVEFGPEYFDGLIIKS---GESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVL-- 21639
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTS 2584
G +L + + G+YT A N G+ VKVQ P PI +
Sbjct: 21640 ---GSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEK 21696
Query: 2585 VILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVS 2643
+ L W P + G I+ Y +E RE W +Y I+ L G YQFRVS
Sbjct: 21697 MTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIK-LINGNEYQFRVS 21755
Query: 2644 ASNPWGISLPSEPSEFVRLPEY------------DAAADGATISWKENFDSAYTELNEIG 2691
A N +G+ P + V +Y + + T++W +E+ +
Sbjct: 21756 AVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQY- 21814
Query: 2692 RGRFSIVKKCIHKATRKDVAVKFVSKK 2718
I+++ K+TR VK +SK+
Sbjct: 21815 -----ILERREKKSTR---WVKVISKR 21833
Score = 63.5 bits (153), Expect = 3e-09
Identities = 49/185 (26%), Positives = 78/185 (42%), Gaps = 18/185 (9%)
Query: 2499 KPTITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
K T+ W P ++ + + S + + + ++ + L+ + I+
Sbjct: 22784 KCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVR 22843
Query: 2550 ATNDHGTTSTSATVKVQG-----VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
A N +G + + +P+ P P +I++W P S G IS Y
Sbjct: 22844 AVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYL 22903
Query: 2605 VEYREEGSQIWQQSVASTL--DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV-- 2660
V+ RE+ S W + + DT L + L GC YQFRV+A N G S PSE S F+
Sbjct: 22904 VDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISC 22963
Query: 2661 RLPEY 2665
R P Y
Sbjct: 22964 REPSY 22968
Score = 62.8 bits (151), Expect = 5e-09
Identities = 51/181 (28%), Positives = 79/181 (43%), Gaps = 15/181 (8%)
Query: 2499 KPTITWKGPDQN--------ILDT-DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
K T+TW P ++ IL+ + S +TV S D L+ + I+
Sbjct: 14116 KATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVS 14175
Query: 2550 ATNDHGTTSTSATVKVQ-----GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
A N +G + V+ G P P +P + + + W P G I+GY
Sbjct: 14176 AVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYH 14235
Query: 2605 VEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLP 2663
VE RE+ S W +++ + + D + L G Y+FRVSA N GI PSE S+ V +
Sbjct: 14236 VERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMK 14295
Query: 2664 E 2664
+
Sbjct: 14296 D 14296
Score = 62.4 bits (150), Expect = 7e-09
Identities = 62/234 (26%), Positives = 94/234 (40%), Gaps = 25/234 (10%)
Query: 2426 RKPKDILGN--KVSVKETNSSEESECDDLDPNT-SMEILNPNFIQEVAPEFLVPLVDVTC 2482
R P I GN + +K N E E +L + + +IL+P ++ +DVTC
Sbjct: 11493 RVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVE----------LDVTC 11542
Query: 2483 L------LGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKIC 2536
+G T+ + +V GRP+P ITW + ++ D + L+I
Sbjct: 11543 RDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQ-----DLPRVELQIK 11597
Query: 2537 NLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTG 2596
+ D G Y A N G SA V V P + + + W P G
Sbjct: 11598 EAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVTKENCTISWENPLDNG 11657
Query: 2597 NCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI 2650
I+ + VEYR+ + W VAS + L+ +L Y FRV A N G+
Sbjct: 11658 GSEITNFIVEYRKPNQKGW-SIVASDVTKRLIKANLLANNEYYFRVCAENKVGV 11710
Score = 62.4 bits (150), Expect = 7e-09
Identities = 51/200 (25%), Positives = 81/200 (40%), Gaps = 25/200 (12%)
Query: 2502 ITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATN 2552
++W P+ N I + S + + T K+ NL+ + A N
Sbjct: 21304 LSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAEN 21363
Query: 2553 DHGTT----STSATVKVQ-GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEY 2607
+G + S+ K Q +P P +P+ + + L W P G ++G+ VE
Sbjct: 21364 RYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEK 21423
Query: 2608 REEGSQIWQQSVASTLD-TYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV------ 2660
+E S +WQ+ S + L G YQFRV A N G+S PS+PS+F
Sbjct: 21424 KERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPV 21483
Query: 2661 ---RLPEY-DAAADGATISW 2676
P+Y D + T+ W
Sbjct: 21484 DPPGTPDYIDVTRETITLKW 21503
Score = 62.4 bits (150), Expect = 7e-09
Identities = 38/111 (34%), Positives = 56/111 (50%), Gaps = 6/111 (5%)
Query: 2470 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG 2529
AP + DVT LG+ L C++ GRP P I W + ++ S Y +SS D
Sbjct: 24160 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ----SRKYKMSS-DGR 24214
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPA-APNRPIAQE 2579
TL + +D G+YTCIATN+ G TS+ + +Q P P P+ ++
Sbjct: 24215 THTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEK 24265
Score = 62.0 bits (149), Expect = 8e-09
Identities = 45/150 (30%), Positives = 67/150 (44%), Gaps = 6/150 (4%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTS---TSATVKVQG--VP 2569
D S+ T+ + S T+K C L + A N +G ++ + TV VP
Sbjct: 15910 DTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVP 15969
Query: 2570 AAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLV 2628
P P+ S S+ ++W P S G + GY +E +E S +W + + + T
Sbjct: 15970 GPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFK 16029
Query: 2629 IEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
L G Y+FRVSA N GI PS+ SE
Sbjct: 16030 TTGLEEGVEYEFRVSAENIVGIGKPSKVSE 16059
Score = 61.6 bits (148), Expect = 1e-08
Identities = 36/104 (34%), Positives = 51/104 (49%), Gaps = 3/104 (2%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLV 2628
PA P R + S +S +L WL P G I+GY +E R++GS W ++ T
Sbjct: 22174 PAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEA-GHTKQLTFT 22232
Query: 2629 IEDLSPGCPYQFRVSASNPWGISLPSE--PSEFVRLPEYDAAAD 2670
+E L Y+FRV A N G S P E S ++ P+ + AD
Sbjct: 22233 VERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTAD 22276
Score = 61.2 bits (147), Expect = 1e-08
Identities = 42/143 (29%), Positives = 64/143 (44%), Gaps = 7/143 (4%)
Query: 2520 TYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ------GVPAAPN 2573
T++ + + + + + NL+P + + A N++G + K P P
Sbjct: 12372 TWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPR 12431
Query: 2574 RPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLVIEDL 2632
+ E + S L WLPP G I GY YREE + + S + D LV+ L
Sbjct: 12432 KLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGL 12491
Query: 2633 SPGCPYQFRVSASNPWGISLPSE 2655
G Y+FRV+A N G+SLP E
Sbjct: 12492 KEGKKYKFRVAARNAVGVSLPRE 12514
Score = 61.2 bits (147), Expect = 1e-08
Identities = 47/189 (24%), Positives = 82/189 (43%), Gaps = 9/189 (4%)
Query: 2520 TYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPI 2576
+Y+ ++ + T K+ L + +A N++G T T+ VK P+ P+
Sbjct: 14541 SYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLN 14600
Query: 2577 AQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGC 2636
+ + ++V L W P G I+GY +E + +GS W + + V+ +L+ G
Sbjct: 14601 IMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTH-ITTVKGLECVVRNLTEGE 14659
Query: 2637 PYQFRVSASNPWGISLPSEP-----SEFVRLPEYDAAADGATISWKENFDSAYTELNEIG 2691
Y F+V A N G S P E E LPE D + + D+ E+ +G
Sbjct: 14660 EYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLG 14719
Query: 2692 RGRFSIVKK 2700
R + ++ K
Sbjct: 14720 RPKPTVTWK 14728
Score = 61.2 bits (147), Expect = 1e-08
Identities = 41/135 (30%), Positives = 60/135 (44%), Gaps = 6/135 (4%)
Query: 2533 LKICNLMPQDSGIYTCIATNDHGT-----TSTSATVKVQGVPAAPNRPIAQERSCTSVIL 2587
LK+ L+ + I+ +A N +G + V G P P P + S+++
Sbjct: 15242 LKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVV 15301
Query: 2588 RWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASN 2646
W P S G I Y VE R++ Q W + TL D + L+ G Y+FR+ A N
Sbjct: 15302 CWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAEN 15361
Query: 2647 PWGISLPSEPSEFVR 2661
GIS PS S F +
Sbjct: 15362 AAGISAPSPTSPFYK 15376
Score = 60.8 bits (146), Expect = 2e-08
Identities = 53/183 (28%), Positives = 76/183 (41%), Gaps = 19/183 (10%)
Query: 2490 LQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG------------EITLKICN 2537
L+ K + T+TW P +LD + Y V +S + + K+
Sbjct: 15586 LKVKEVTKTSVTLTWDPP---LLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQ 15642
Query: 2538 LMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSS 2594
L S + +A N++G T+ +VK P P + + + SV L W P
Sbjct: 15643 LQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKPEH 15702
Query: 2595 TGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPS 2654
G I GY VE + +GS W + A+ T I L G Y FRVSA N GIS P
Sbjct: 15703 DGGSRILGYIVEMQTKGSDKW-ATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPR 15761
Query: 2655 EPS 2657
+ S
Sbjct: 15762 QLS 15764
Score = 60.1 bits (144), Expect = 3e-08
Identities = 47/176 (26%), Positives = 76/176 (43%), Gaps = 15/176 (8%)
Query: 2499 KPTITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
K T+ WK P Q+ + + S +TV + ++ K+ L+ + + +
Sbjct: 16281 KCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRIM 16340
Query: 2550 ATNDHGTTSTSATVKVQG-----VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
A N +G + V VP AP P + S+I+ W P+S G I GY
Sbjct: 16341 AVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYV 16400
Query: 2605 VEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF 2659
+E R++ W + + + L + L Y+FRVSA N G+S PS PS +
Sbjct: 16401 LEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAY 16456
Score = 60.1 bits (144), Expect = 3e-08
Identities = 44/150 (29%), Positives = 68/150 (45%), Gaps = 6/150 (4%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTST--SATVKVQ---GVP 2569
D ++ T+ + S T+KI L + A N +G ++ S V VQ P
Sbjct: 18074 DTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEP 18133
Query: 2570 AAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLV 2628
P P S ++++W P + G I GY +E +E+ S +W + + + DT
Sbjct: 18134 GPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFK 18193
Query: 2629 IEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
L G Y+F+VSA N GI PS+ SE
Sbjct: 18194 TTGLDEGLEYEFKVSAENIVGIGKPSKVSE 18223
Score = 59.7 bits (143), Expect = 4e-08
Identities = 42/145 (28%), Positives = 68/145 (46%), Gaps = 6/145 (4%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAA 2571
+ + Y + + + T +I NL S + +A+N++G T+ VKV P
Sbjct: 18867 ETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLP 18926
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P R + + + ++W P S G I+GY VE + +GS+ W + TL+ I
Sbjct: 18927 PGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEA--TIS 18984
Query: 2631 DLSPGCPYQFRVSASNPWGISLPSE 2655
L+ G Y FRV+A N G S P +
Sbjct: 18985 GLTAGEEYVFRVAAVNEKGRSDPRQ 19009
Score = 59.3 bits (142), Expect = 6e-08
Identities = 37/113 (32%), Positives = 51/113 (45%), Gaps = 5/113 (4%)
Query: 2558 STSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ 2617
ST ATV P P ++R+ S+ L W PP + G I GY VE GS W
Sbjct: 7210 STPATV-----PDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVA 7264
Query: 2618 SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAAD 2670
+T + + L G Y +RV A N G S PS P+E ++ + A +
Sbjct: 7265 CGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPE 7317
Score = 58.2 bits (139), Expect = 1e-07
Identities = 49/177 (27%), Positives = 65/177 (36%), Gaps = 22/177 (12%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTC------------ 2548
T+TW PD D + Y V D CN MP Y
Sbjct: 7528 TLTWCEPDD---DGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFR 7584
Query: 2549 -IATNDHGTTSTSATVKVQGV------PAAPNRPIAQERSCTSVILRWLPPSSTGNCTIS 2601
+A N G S + + + P P +P ++ TSV L W P G I
Sbjct: 7585 VLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIE 7644
Query: 2602 GYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
Y +E + G+ W + T ++ L G Y FRV A N G S PSEPS+
Sbjct: 7645 SYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSD 7701
Score = 58.2 bits (139), Expect = 1e-07
Identities = 33/92 (35%), Positives = 48/92 (52%), Gaps = 1/92 (1%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTY- 2626
VP AP P + SV L W P TG I+GY +E++E S +W+++ + +
Sbjct: 13803 VPDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRD 13862
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
+ L+ G Y+FRV A N G+ PS PSE
Sbjct: 13863 FKVTGLTEGLEYEFRVMAINLAGVGKPSLPSE 13894
Score = 58.2 bits (139), Expect = 1e-07
Identities = 42/173 (24%), Positives = 75/173 (43%), Gaps = 15/173 (8%)
Query: 2501 TITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIAT 2551
TI+W P+ + + + +S T+ + S ++KI L + A
Sbjct: 19133 TISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAE 19192
Query: 2552 NDHGTTSTSATVKVQGV-----PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVE 2606
N +G +S S + V P P P + +++++ W P + G + GY +E
Sbjct: 19193 NRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLE 19252
Query: 2607 YREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
Y+E S +W ++ + DT + + L G Y++RV A N GI S+ E
Sbjct: 19253 YKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCE 19305
Score = 57.8 bits (138), Expect = 2e-07
Identities = 50/205 (24%), Positives = 83/205 (40%), Gaps = 37/205 (18%)
Query: 2490 LQCKVCGRPKP---------------TITWKGPDQN---------ILDTDNSSATYTVSS 2525
++ V GRP P T++W P + I + + T+ S
Sbjct: 9837 MRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVS 9896
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGT-----TSTSATVKVQGVPAAPNRPIAQER 2580
+ E T I L+ ++ +A N +G + + VP AP++P
Sbjct: 9897 SEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSV 9956
Query: 2581 SCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-----SVASTLDTYLVIEDLSPG 2635
+ S+ + W P G ++GY +E ++ S+ W++ A TL + L G
Sbjct: 9957 TRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEG 10016
Query: 2636 CPYQFRVSASNPWGI---SLPSEPS 2657
YQFRV A N G+ SLPS+P+
Sbjct: 10017 SDYQFRVYAINAAGVGPASLPSDPA 10041
Score = 57.8 bits (138), Expect = 2e-07
Identities = 51/178 (28%), Positives = 78/178 (43%), Gaps = 17/178 (9%)
Query: 2490 LQCKVCGRPKPTITWKGP---------DQNILDTDNSSATYTVSSCDSGEITLKICNLMP 2540
LQ K R T+ W P + I D + T++V S + K+ +L
Sbjct: 21000 LQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSE 21059
Query: 2541 QDSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQERSC-TSVILRWLPPSSTG 2596
+ + +A N+ G T+ VK VPA P R ++ + S TSVIL W P G
Sbjct: 21060 KTPFFFRVLAENEIGIGEPCETTEPVKAAEVPA-PIRDLSMKDSTKTSVILSWTKPDFDG 21118
Query: 2597 NCTISGYTVEYREEGSQIWQQS-VASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP 2653
I+ Y VE + +G Q W + ++ T + + + L +FRV A N G+S P
Sbjct: 21119 GSVITEYVVERKGKGEQTWSHAGISKTCE--IEVSQLKEQSVLEFRVFAKNEKGLSDP 21174
Score = 57.4 bits (137), Expect = 2e-07
Identities = 69/297 (23%), Positives = 112/297 (37%), Gaps = 36/297 (12%)
Query: 2390 AESSDGSIKKSCSWHTL-----RMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSS 2444
++SSD I K L MRK V+ T P + + + S +T+
Sbjct: 19797 SDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLR 19856
Query: 2445 EESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKP---- 2500
+ D D TS+ I N N + + ++ + + +V T+++ KV P P
Sbjct: 19857 TRAYVDTTDSRTSLTIENAN--RNDSGKYTLTIQNVLSAASLTLVV--KVLDTPGPPTNI 19912
Query: 2501 ----------TITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQ 2541
++W P+ + I + S + + + ++ K+ NL
Sbjct: 19913 TVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNLQEG 19972
Query: 2542 DSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNC 2598
+ N+ G T VK+ P+ P + S SV L WL P G
Sbjct: 19973 AIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGS 20032
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
I Y VE E+G + W + + T+ V+ L Y FRV A N G+S P E
Sbjct: 20033 RIVHYVVEALEKGQKNWVKCAVAK-STHHVVSGLRENSEYFFRVFAENQAGLSDPRE 20088
Score = 57.0 bits (136), Expect = 3e-07
Identities = 34/93 (36%), Positives = 47/93 (50%), Gaps = 3/93 (3%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ---SVASTLDT 2625
P+ P P A + +C SV L W PP G I GY VEY++ G + W++ + S +T
Sbjct: 10741 PSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPET 10800
Query: 2626 YLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
+ L G Y+FRV A N G S P+ E
Sbjct: 10801 KYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPE 10833
Score = 57.0 bits (136), Expect = 3e-07
Identities = 46/183 (25%), Positives = 78/183 (42%), Gaps = 23/183 (12%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVSSCDSG------------EITLKICNLMPQDSGIYTC 2548
+++W P + D ++ Y V CD + + ++ L+P I+
Sbjct: 12638 SLSWHIP---LEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRV 12694
Query: 2549 IATNDHGTTSTSATVKVQ-----GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
A N G + + K+ GVP+ P + + + + W P S G I GY
Sbjct: 12695 RAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGY 12754
Query: 2604 TVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV-- 2660
+E +E S +W ++ + + T L G Y FR+ A N G S PS+P+E+V
Sbjct: 12755 LIERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTA 12814
Query: 2661 RLP 2663
R+P
Sbjct: 12815 RMP 12817
Score = 56.6 bits (135), Expect = 4e-07
Identities = 42/142 (29%), Positives = 61/142 (42%), Gaps = 4/142 (2%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAA 2571
+++ Y S + + K+ NL + +A N+ G T VK P+
Sbjct: 17784 ESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSP 17843
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIED 2631
P + + S TS L W P G + GY VE + +G++ W VA + V+
Sbjct: 17844 PGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKW-SIVAESKVCNAVVTG 17902
Query: 2632 LSPGCPYQFRVSASNPWGISLP 2653
LS G YQFRV A N G S P
Sbjct: 17903 LSSGQEYQFRVKAYNEKGKSDP 17924
Score = 56.6 bits (135), Expect = 4e-07
Identities = 43/151 (28%), Positives = 60/151 (39%), Gaps = 7/151 (4%)
Query: 2535 ICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ------GVPAAPNRPIAQERSCTSVILR 2588
+ L+P + IA ND G + TS + P+ P S SV L+
Sbjct: 24019 VTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQ 24078
Query: 2589 WLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNP 2647
W P G I GY VEYR+ G W++S + D I L Y+FRV A N
Sbjct: 24079 WEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENE 24138
Query: 2648 WGISLPSEPSEFVRLPEYDAAADGATISWKE 2678
G+S P + ++ A G K+
Sbjct: 24139 TGLSRPRRTAMSIKTKLTSGEAPGIRKEMKD 24169
Score = 56.6 bits (135), Expect = 4e-07
Identities = 48/177 (27%), Positives = 71/177 (40%), Gaps = 23/177 (12%)
Query: 2502 ITWKGPDQNILDTDNSSATYTVSSCDSGE-------------ITLKICNLMPQDSGIYTC 2548
I+WK P D + Y V C++ E T +I NL +
Sbjct: 24370 ISWKPPAD---DGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRV 24426
Query: 2549 IATNDHGTTS---TSATVKVQGV---PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISG 2602
A N G + S+ V ++ P AP +P + S ++ W PP+S G I
Sbjct: 24427 SAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRN 24486
Query: 2603 YTVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
Y +E RE+ W + +T +++L G Y+FRV N G S SE SE
Sbjct: 24487 YYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISE 24543
Score = 56.2 bits (134), Expect = 5e-07
Identities = 50/186 (26%), Positives = 75/186 (40%), Gaps = 20/186 (10%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDS------------GEIT 2532
G V + K + +TW+ P I+D + Y V D+ + +
Sbjct: 13416 GPPVNVTVKEISKDSAYVTWEPP---IIDGGSPIINYVVQKRDAERKSWSTVTTECSKTS 13472
Query: 2533 LKICNLMPQDSGIYTCIATNDHGTTSTSAT---VKVQGVPAAPNRPIAQERSCTSVILRW 2589
++ NL S + A N++G T VK P + S +S + W
Sbjct: 13473 FRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGW 13532
Query: 2590 LPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG 2649
P S G I GY V++ E ++ WQ+ V +L +DL+ G Y FRVSA N G
Sbjct: 13533 KKPHSDGGSRIIGYVVDFLTEENK-WQR-VMKSLSLQYSAKDLTEGKEYTFRVSAENENG 13590
Query: 2650 ISLPSE 2655
PSE
Sbjct: 13591 EGTPSE 13596
Score = 55.8 bits (133), Expect = 6e-07
Identities = 46/175 (26%), Positives = 74/175 (42%), Gaps = 14/175 (8%)
Query: 2501 TITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIAT 2551
TI+W+ P + + D T+ V S S + LKI +L ++ A
Sbjct: 11250 TISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAE 11309
Query: 2552 NDHGT----TSTSATVKVQ-GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVE 2606
N G ST K + P+ P +P+ + + + + W P S G I+GY +E
Sbjct: 11310 NKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYME 11369
Query: 2607 YREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVR 2661
RE + + + D + L G Y+FRV A N G+S PS S+ ++
Sbjct: 11370 RREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIK 11424
Score = 55.5 bits (132), Expect = 8e-07
Identities = 53/246 (21%), Positives = 98/246 (39%), Gaps = 22/246 (8%)
Query: 2389 AAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESE 2448
+A + G++ SC + +++ + E E T E + + + V + +T+ +EE
Sbjct: 970 SAVNEAGTVSTSC-YLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQA 1028
Query: 2449 CDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPD 2508
P + AP F+ V + G +V+ C+V G PKP + WK
Sbjct: 1029 -------------GPG--EPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSG 1073
Query: 2509 QNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG- 2567
+ +Y + +GE L I D+G YT + N HG TS SA++ +
Sbjct: 1074 VPLTTGYRYKVSY---NKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEAD 1130
Query: 2568 --VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDT 2625
+ + + + T+ + + S Y EY +E + I ++ T+
Sbjct: 1131 YELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVV 1190
Query: 2626 YLVIED 2631
+ED
Sbjct: 1191 RTYVED 1196
Score = 53.9 bits (128), Expect = 2e-06
Identities = 31/90 (34%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIW-QQSVASTLDTYL 2627
P+AP RP S ++ +RW P G I GY VE +E + +W +++ L+
Sbjct: 22469 PSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNY 22528
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSEPS 2657
+ L G YQFR A N G+S SE S
Sbjct: 22529 KVTGLVEGLEYQFRTYALNAAGVSKASEAS 22558
Score = 53.5 bits (127), Expect = 3e-06
Identities = 31/92 (33%), Positives = 50/92 (54%), Gaps = 7/92 (7%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-----SVASTL 2623
P P+ P ++++ +S+ L W PP+ G I GY VE +EEG+ W++ + +T
Sbjct: 9333 PGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTC 9392
Query: 2624 DTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
+ V+ +L Y+FRV A N G S PS+
Sbjct: 9393 E--CVVPNLKELRKYRFRVKAVNEAGESEPSD 9422
Score = 53.5 bits (127), Expect = 3e-06
Identities = 34/92 (36%), Positives = 42/92 (45%), Gaps = 1/92 (1%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTY 2626
VP P P + S+ + W P S G I GY VE +E +WQ S A
Sbjct: 14886 VPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNI 14945
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
L+ G Y+FRV A N G S PS+PSE
Sbjct: 14946 FKSSGLTDGIAYEFRVIAENMAGKSKPSKPSE 14977
Score = 53.5 bits (127), Expect = 3e-06
Identities = 42/152 (27%), Positives = 65/152 (42%), Gaps = 14/152 (9%)
Query: 2533 LKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG------VPAAPNRPIAQERSCTSVI 2586
LK+ +LM + A N G + S P P+ P + + S+
Sbjct: 22928 LKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSIS 22987
Query: 2587 LRWLPPSSTGNCTISGYTVEYREEGSQIWQQ--SVASTLDTYLVIEDLSPGCPYQFRVSA 2644
L W P G I GY +E +E+ + W + + A+ +T + DL G Y FRV+A
Sbjct: 22988 LAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAA 23047
Query: 2645 SNPWGISLPS------EPSEFVRLPEYDAAAD 2670
N G+S S EP E + +P+ + A D
Sbjct: 23048 VNVKGMSEYSESIAEIEPVERIEIPDLELADD 23079
Score = 53.1 bits (126), Expect = 4e-06
Identities = 31/96 (32%), Positives = 47/96 (48%), Gaps = 5/96 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P+ L L VT G + GRP+P I+W +Q + S+ D E
Sbjct: 3193 PQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLL-----STGFKCKFLHDGQE 3247
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
TL + P+D+ +YTC A ND+G +TSA++ V+
Sbjct: 3248 YTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVE 3283
Score = 53.1 bits (126), Expect = 4e-06
Identities = 30/71 (42%), Positives = 38/71 (53%), Gaps = 1/71 (1%)
Query: 2583 TSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRV 2642
T V L W P G I+GY VEY+EEG+Q W + T + V+ L G Y+FRV
Sbjct: 11052 TEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVT-NLECVVTGLQQGKTYRFRV 11110
Query: 2643 SASNPWGISLP 2653
A N G+ LP
Sbjct: 11111 KAENIVGLGLP 11121
Score = 52.8 bits (125), Expect = 5e-06
Identities = 33/94 (35%), Positives = 49/94 (52%), Gaps = 5/94 (5%)
Query: 2567 GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTY 2626
G P AP++PI ++ + S++++W P G+ I GY +E RE S W + S L+
Sbjct: 8529 GPPDAPDKPIVEDVTSNSMLVKWNEPKDNGS-PILGYWLEKREVNSTHWSRVNKSLLNAL 8587
Query: 2627 LV-IEDLSPGCPYQFRVSASN---PWGISLPSEP 2656
++ L G Y FRV A N P S PS+P
Sbjct: 8588 KANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDP 8621
Score = 52.8 bits (125), Expect = 5e-06
Identities = 48/187 (25%), Positives = 79/187 (42%), Gaps = 15/187 (8%)
Query: 2490 LQCKVCGRPKPTITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMP 2540
++ K K T+ W+ P + + + S +++ S E + ++
Sbjct: 20601 IEFKTVTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLEECIITTTKIIK 20660
Query: 2541 QDSGIYTCIATNDHGT----TSTSATVKVQGV-PAAPNRPIAQERSCTSVILRWLPPSST 2595
+ I+ A N +G S S K V P P P + + S+ + W P +
Sbjct: 20661 GNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIAD 20720
Query: 2596 GNCTISGYTVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPS 2654
G ISGY +E R++ S W + + T+ DT + L+ YQ+RV A N G S
Sbjct: 20721 GGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFS 20780
Query: 2655 EPSEFVR 2661
EPSEF +
Sbjct: 20781 EPSEFYK 20787
Score = 52.8 bits (125), Expect = 5e-06
Identities = 56/202 (27%), Positives = 79/202 (39%), Gaps = 33/202 (16%)
Query: 2468 EVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCD 2527
E PEF +PL + T +G+ V + P+P +TW Q I DN YT S D
Sbjct: 25315 ERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDK-KYTFES-D 25372
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPN---RPIAQ------ 2578
G L I ++ D YT +A N +G S A + V P + RP+ +
Sbjct: 25373 KGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANA 25432
Query: 2579 -----ERSCTSVILRWLPP-----SSTGNCTISGYTVEYREEGSQIWQQSVASTLDTY-L 2627
+ C + + +PP G G +E EG LD Y L
Sbjct: 25433 ECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEG-----------LDYYAL 25481
Query: 2628 VIEDLSPGCPYQFRVSASNPWG 2649
I D P +RV+A+N G
Sbjct: 25482 HIRDTLPEDTGYYRVTATNTAG 25503
Score = 52.4 bits (124), Expect = 7e-06
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 1/90 (1%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYL 2627
P P+ P + S + + W PP G +I+GY +E +E+ S W S + + +
Sbjct: 12024 PGRPDPPEVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPERRM 12083
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSEPS 2657
+++L P YQFRV A N GI PS PS
Sbjct: 12084 KVQNLLPDHEYQFRVKAENEIGIGEPSLPS 12113
Score = 51.6 bits (122), Expect = 1e-05
Identities = 45/172 (26%), Positives = 78/172 (45%), Gaps = 17/172 (9%)
Query: 2501 TITWKGPDQN---------ILDTDNSSATY-TVSSCDSGEITLKICNLMPQDSGIYTCIA 2550
++TW+ P+ + I D +S + T + + +++ + +++ + A
Sbjct: 6836 SLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRA 6895
Query: 2551 TNDHGTTSTSAT---VKVQGVPAAPNRPI---AQERSCTSVILRWLPPSSTGNCTISGYT 2604
N G SA VKV P+ P+ + +++ +SV L+W PP G I GY
Sbjct: 6896 QNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYI 6955
Query: 2605 VEYREEGSQIW-QQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
+E EEG W + ++ + + L G Y +RVSA N G+S PSE
Sbjct: 6956 IERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSE 7007
Score = 51.6 bits (122), Expect = 1e-05
Identities = 32/104 (30%), Positives = 48/104 (46%), Gaps = 3/104 (2%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL--DTY 2626
P P+ P + + S L W P G I+GY VE+++ G + W + T T
Sbjct: 14301 PGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQ 14360
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAAD 2670
V+ DL Y FR+SA N G+ P+ + V + E + A D
Sbjct: 14361 FVVPDLQTKEKYNFRISAINDAGVGEPAVIPD-VEIVEREMAPD 14403
Score = 51.6 bits (122), Expect = 1e-05
Identities = 30/91 (32%), Positives = 48/91 (52%), Gaps = 2/91 (2%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIW-QQSVASTLDTYLVIE 2630
P +P+ + +V L+W P TG I+ Y VE R+ + W + + ++ L+ +
Sbjct: 14988 PGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVS 15047
Query: 2631 DLSPGCPYQFRVSASNPWG-ISLPSEPSEFV 2660
L+ Y+FRV A N G IS PSEPS+ +
Sbjct: 15048 GLTEDAAYEFRVIAKNAAGAISPPSEPSDAI 15078
Score = 50.8 bits (120), Expect = 2e-05
Identities = 45/178 (25%), Positives = 77/178 (43%), Gaps = 15/178 (8%)
Query: 2499 KPTITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
K ++TW P Q+ + + S +TV + + +LK+ L+ + ++ +
Sbjct: 17363 KCSLTWSPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIM 17422
Query: 2550 ATNDHGTTST--SATVKVQGVPAAPNRPIAQERSCT---SVILRWLPPSSTGNCTISGYT 2604
A N +G SA V ++ P P + E + S+ + W P S G I GY
Sbjct: 17423 AVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYI 17482
Query: 2605 VEYREEGSQIW-QQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVR 2661
VE R+ W + + D L + L+ Y+FRVSA N G+ PS + + +
Sbjct: 17483 VEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYK 17540
Score = 50.4 bits (119), Expect = 3e-05
Identities = 56/219 (25%), Positives = 87/219 (39%), Gaps = 31/219 (14%)
Query: 2454 PNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILD 2513
P ++E+ F EV+ + PL D G + I+ V R TW +L
Sbjct: 6720 PVRNLEVTE-TFDGEVSLAWEEPLTD-----GGSKIIGYVVERRDIKRKTW------VLA 6767
Query: 2514 TDNS-SATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQG-- 2567
TD + S +TV+ G + ++ A N GT T V+ +
Sbjct: 6768 TDRAESCEFTVTGLQKGGVEY-----------LFRVSARNRVGTGEPVETDNPVEARSKY 6816
Query: 2568 -VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSV-ASTLDT 2625
VP P + + V L W PP G I+ Y +E R++ S W ++ D
Sbjct: 6817 DVPGPPLNVTITDVNRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDL 6876
Query: 2626 YLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
+ D+ G Y FRV A N G+ PS + FV++ +
Sbjct: 6877 SATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVAD 6915
Score = 50.4 bits (119), Expect = 3e-05
Identities = 47/168 (27%), Positives = 68/168 (40%), Gaps = 19/168 (11%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVSSCDSGEITL------------KICNLMPQDSGIYTC 2548
+ITW+ P +LD + Y V ++ + KI L S +
Sbjct: 16679 SITWEPP---LLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRV 16735
Query: 2549 IATNDHGT---TSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTV 2605
A N++G T+ +KV VP P + + + SV L W P G I Y V
Sbjct: 16736 TAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIV 16795
Query: 2606 EYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP 2653
E + + S+ W + A VI +L+ G Y FRV A N G S P
Sbjct: 16796 EMQAKHSEKWSE-CARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDP 16842
Score = 50.1 bits (118), Expect = 3e-05
Identities = 33/98 (33%), Positives = 45/98 (45%), Gaps = 4/98 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F++ V CL G T KV GRP P W Q I+ + T+ V + G
Sbjct: 1411 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIV----NDYTHKVVIKEDGT 1466
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGV 2568
+L I P DSG +T +A N G +S S + V+ V
Sbjct: 1467 QSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAV 1504
Score = 49.7 bits (117), Expect = 4e-05
Identities = 33/88 (37%), Positives = 45/88 (51%), Gaps = 3/88 (3%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P RP A + SV L+W P+ G I+GY VE +E W + S + +DT+ +
Sbjct: 16070 PGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVT 16129
Query: 2631 DLSPGCPYQFRVSASNPWGISLPSEPSE 2658
L Y+FRV A N G+ SEPSE
Sbjct: 16130 GLVEDHRYEFRVIARNAAGVF--SEPSE 16155
Score = 49.7 bits (117), Expect = 4e-05
Identities = 51/196 (26%), Positives = 81/196 (41%), Gaps = 21/196 (10%)
Query: 2477 LVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG-----EI 2531
LV V G ++ K R TITW+ P +D Y V ++ +
Sbjct: 23159 LVKVYDTPGPCPSVKVKEVSRDSVTITWEIPT---IDGGAPVNNYIVEKREAAMRAFKTV 23215
Query: 2532 TLKICNLMPQDSGI-------YTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQERS 2581
T K + + SG+ + + N +G TS V V VP P + + +
Sbjct: 23216 TTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVT 23275
Query: 2582 CTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYL--VIEDLSPGCPYQ 2639
++V L W P G ++GY +E + G++ W + V + T L + L+ G Y
Sbjct: 23276 KSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMK-VVTLKPTVLEHTVTSLNEGEQYL 23334
Query: 2640 FRVSASNPWGISLPSE 2655
FR+ A N G+S P E
Sbjct: 23335 FRIRAQNEKGVSEPRE 23350
Score = 49.7 bits (117), Expect = 4e-05
Identities = 46/177 (25%), Positives = 70/177 (39%), Gaps = 23/177 (12%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVSSCDSGE------------ITLKICNLMPQDSGIYTC 2548
TI+W+ P+ LD + Y V D+ T K L + ++
Sbjct: 23478 TISWEPPE---LDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRV 23534
Query: 2549 IATNDHGTTSTSATVKVQ-----GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
ATN G S + ++ +P P + S + L W PP G ++GY
Sbjct: 23535 AATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGY 23594
Query: 2604 TVEYREEGSQIWQQ--SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
VE +E + W + V T+ Y L+ G Y+ RV+A N G PS PS+
Sbjct: 23595 IVERKEVRADRWVRVNKVPVTMTRYR-STGLTEGLEYEHRVTAINARGSGKPSRPSK 23650
Score = 49.3 bits (116), Expect = 6e-05
Identities = 48/203 (23%), Positives = 78/203 (38%), Gaps = 14/203 (6%)
Query: 2472 EFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQN--------ILDTDNSSATYTV 2523
+F V+V + G + L+ V R + W P+ + I++ ++
Sbjct: 8813 KFAAARVEVFDVPGPVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWR 8872
Query: 2524 SSCDSGEITLKICNLMPQDSGIYTCIATNDHGT-----TSTSATVKVQGVPAAPNRPIAQ 2578
++ I L+ + IA N G V G P +P R
Sbjct: 8873 QPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYT 8932
Query: 2579 ERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGCP 2637
ER+ +++ L W P S G I GY +E R +++ + T ++E+L
Sbjct: 8933 ERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQM 8992
Query: 2638 YQFRVSASNPWGISLPSEPSEFV 2660
Y+FRV A N G S PS P V
Sbjct: 8993 YEFRVKAVNEIGESEPSLPLNVV 9015
Score = 49.3 bits (116), Expect = 6e-05
Identities = 71/323 (21%), Positives = 121/323 (37%), Gaps = 34/323 (10%)
Query: 2398 KKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTS 2457
KK W ++ + E + KN G L + VK N ESE ++ S
Sbjct: 24494 KKQNKWISVTTEEIRETVFSVKNLIEG-------LEYEFRVKCENLGGESEWSEI----S 24542
Query: 2458 MEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNS 2517
I + + AP F L ++ L CKV G PKP + W + I+
Sbjct: 24543 EPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEII---AD 24599
Query: 2518 SATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA 2577
Y + G L I ++ D+ +Y ATN G+ S +A+++V+ VPA + P
Sbjct: 24600 GLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVE-VPAKIHLPKT 24658
Query: 2578 QERSCTSVILRW------LPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIED 2631
E LR +P S + I+ + + + +Q V + + +
Sbjct: 24659 LEGMGAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNG 24718
Query: 2632 LSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE-------YDAAADGATISWKENFDSAY 2684
+ + V A N +GI + + +P+ D + D ++W E
Sbjct: 24719 VERKDAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGG 24778
Query: 2685 TELNEIGRGRFSIVKKCIHKATR 2707
+++ IV+KC A R
Sbjct: 24779 SKITNY------IVEKCATTAER 24795
Score = 48.9 bits (115), Expect = 7e-05
Identities = 29/95 (30%), Positives = 46/95 (48%), Gaps = 4/95 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P FL L + C G I + V G P PT+TW ++ + +S YT+ +G
Sbjct: 3700 PHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLC----TSVYYTIIHNPNGS 3755
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV 2565
T + + +DSG+Y C A N G ++ +A + V
Sbjct: 3756 GTFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3790
Score = 48.5 bits (114), Expect = 1e-04
Identities = 49/163 (30%), Positives = 73/163 (44%), Gaps = 20/163 (12%)
Query: 2418 GKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPL 2477
G+ + T P K G + S+K TN S ++ + E PNF+Q L
Sbjct: 61 GRAKLTIPAVTKANSG-RYSLKATNGSGQAT-STAELLVKAETAPPNFVQR--------L 110
Query: 2478 VDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEI-TLKIC 2536
+T G V LQ +V G P P + + I SS + +S G++ +L I
Sbjct: 111 QSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEI----QSSLDFQISQ--EGDLYSLLIA 164
Query: 2537 NLMPQDSGIYTCIATNDHGTTSTSATVKVQG---VPAAPNRPI 2576
P+DSG Y+ ATN G +++A + VQG VPA + I
Sbjct: 165 EAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTI 207
Score = 48.5 bits (114), Expect = 1e-04
Identities = 33/99 (33%), Positives = 49/99 (49%), Gaps = 3/99 (3%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P +P + SV L W P G ++GY VE R+ S+ W + + + + +
Sbjct: 13905 PGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVT 13964
Query: 2631 DLSPGCPYQFRVSASNPWG-ISLPSEPSE-FVRLPEYDA 2667
DL G Y+FR+ A N G IS PSE +E + EY+A
Sbjct: 13965 DLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEA 14003
Score = 48.5 bits (114), Expect = 1e-04
Identities = 30/95 (31%), Positives = 44/95 (46%), Gaps = 2/95 (2%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQ--QSVASTLDTY 2626
P P + + + +S+ L W P G ++GY VE R+ + W + T
Sbjct: 20795 PGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTE 20854
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVR 2661
V+ +L PG Y FRVSA N G P E +E V+
Sbjct: 20855 YVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQ 20889
Score = 48.1 bits (113), Expect = 1e-04
Identities = 36/127 (28%), Positives = 46/127 (36%), Gaps = 1/127 (0%)
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRW 2589
+ + +I D G Y + N HG +KV VP E V L W
Sbjct: 6679 QTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLAW 6738
Query: 2590 LPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSP-GCPYQFRVSASNPW 2648
P + G I GY VE R+ + W + + L G Y FRVSA N
Sbjct: 6739 EEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSARNRV 6798
Query: 2649 GISLPSE 2655
G P E
Sbjct: 6799 GTGEPVE 6805
Score = 47.8 bits (112), Expect = 2e-04
Identities = 33/102 (32%), Positives = 48/102 (47%), Gaps = 5/102 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F+ PL + G+TV +V G PKP I W Q IL T + + S +G
Sbjct: 3419 PSFIQPLSSLRVHNGETVRFHARVSGIPKPEIQWFHNQQLILPTKDVVFHFEES---TGM 3475
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAP 2572
+ I + + +G Y+C A N G + +AT+ V P AP
Sbjct: 3476 ALMLIVDAYSEHAGQYSCKAANSAGEATCAATLTV--TPKAP 3515
Score = 47.8 bits (112), Expect = 2e-04
Identities = 34/104 (32%), Positives = 47/104 (45%), Gaps = 15/104 (14%)
Query: 2567 GVPAAPNRPIAQERSC-------------TSVILRWLPPSSTGNCTISGYTVEYREEGSQ 2613
G P+ P+ P+ +C SV L W P+ G I+GY VE R+
Sbjct: 20381 GKPSHPSEPVLAIDACEPPRNVRITDISKNSVSLSWQQPAFDGGSKITGYIVERRDLPDG 20440
Query: 2614 IW-QQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG-ISLPSE 2655
W + S + +T +I L+ Y+FRV A N G IS PSE
Sbjct: 20441 RWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSE 20484
Score = 47.8 bits (112), Expect = 2e-04
Identities = 30/99 (30%), Positives = 44/99 (44%), Gaps = 2/99 (2%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVAS--TLDT 2625
VP AP P + S+ L W P S G I Y +E RE+ S W + ++ +T
Sbjct: 21779 VPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISET 21838
Query: 2626 YLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
+ L+ G Y+F V A N G+ S S ++ E
Sbjct: 21839 RFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCRE 21877
Score = 47.8 bits (112), Expect = 2e-04
Identities = 29/105 (27%), Positives = 45/105 (42%), Gaps = 7/105 (6%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYL 2627
P P P + + TSV L W P G ++GY +E ++ W + + T
Sbjct: 23661 PGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREY 23720
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSE------PSEFVRLPEYD 2666
+ L G Y+FRV A N G P+E +E + P+Y+
Sbjct: 23721 TLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYE 23765
Score = 47.4 bits (111), Expect = 2e-04
Identities = 30/90 (33%), Positives = 42/90 (46%), Gaps = 6/90 (6%)
Query: 2483 LLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQD 2542
L G V CK+ G P P I W + I + Y + G +L+I ++P+D
Sbjct: 1257 LEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGER----YQMDFLQDGRASLRIPVVLPED 1312
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAP 2572
GIYT A+N G S + V+ PAAP
Sbjct: 1313 EGIYTAFASNIKGNAICSGKLYVE--PAAP 1340
Score = 47.4 bits (111), Expect = 2e-04
Identities = 27/87 (31%), Positives = 40/87 (45%), Gaps = 1/87 (1%)
Query: 2573 NRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIW-QQSVASTLDTYLVIED 2631
N P + + +SV L W P G ++GY +E +E + W + + T +
Sbjct: 23962 NPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTG 24021
Query: 2632 LSPGCPYQFRVSASNPWGISLPSEPSE 2658
L P YQFR+ A N G+S S SE
Sbjct: 24022 LVPDAEYQFRIIAQNDVGLSETSPASE 24048
Score = 47.0 bits (110), Expect = 3e-04
Identities = 42/165 (25%), Positives = 72/165 (43%), Gaps = 29/165 (17%)
Query: 2425 PRKPKDILGNKVS------VKETNSS---------EESECDDLDPNTSMEILNPNFI--- 2466
P+ P+ IL ++ +KE +SS +E N ++E+L+ + +
Sbjct: 3512 PKAPESILHERIEQEIEMEMKEFSSSFLSAEEEGLHSAELQLSKINETLELLSESPVYPT 3571
Query: 2467 ------QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSAT 2520
+ P F+ + + +GD L V G PKP I W +L T ++
Sbjct: 3572 KFDSEKEGTGPIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFF--NGVLLTPSADYK 3629
Query: 2521 YTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV 2565
+ D + +L I +D G YTC+A+ND+G T SA +K+
Sbjct: 3630 FVF---DGDDHSLIILFTKLEDEGEYTCMASNDYGKTICSAYLKI 3671
Score = 46.6 bits (109), Expect = 4e-04
Identities = 80/342 (23%), Positives = 124/342 (36%), Gaps = 60/342 (17%)
Query: 2349 QVLAVNQQNMCLVYQP-----ASDHSPAAEGWVPGSILAPLT-----KATAAESSDGSIK 2398
+V A+N+Q +P A D A E ++ +LA LT K + G +
Sbjct: 7288 RVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPE 7347
Query: 2399 KSCSWHT----LRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEE-SECDDLD 2453
+W L+ KR +EN K I+ +K S T E + C
Sbjct: 7348 PKITWTKADMILKQDKRITIENVPKKSTV------TIVDSKRSDTGTYIIEAVNVC---- 7397
Query: 2454 PNTSMEILNPNFIQEVAPEFLVPLVDVT---CLL--------GDTVILQCKVCGRPKPTI 2502
+ ++ N + + P + DVT CLL G + I V R +
Sbjct: 7398 -GRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSE 7456
Query: 2503 TWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT----TS 2558
W + DT+ K L+P I+ A N +G +
Sbjct: 7457 VWHKLSSTVKDTN-----------------FKATKLIPNKEYIFRVAAENMYGVGEPVQA 7499
Query: 2559 TSATVKVQ-GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ 2617
+ T K Q P P R + + +V L W P G I+GY VE + + W +
Sbjct: 7500 SPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVR 7559
Query: 2618 -SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
+ DT ++ L+ Y+FRV A N G PS+ +E
Sbjct: 7560 CNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTE 7601
Score = 46.6 bits (109), Expect = 4e-04
Identities = 26/88 (29%), Positives = 40/88 (45%), Gaps = 1/88 (1%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDT-YL 2627
P P P + S T++ L W PP+ G I GY V+ + G+ W + +
Sbjct: 8630 PPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQY 8689
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSE 2655
++++ G Y+ RVSA N G P E
Sbjct: 8690 TVKEIREGADYKLRVSAVNAAGEGPPGE 8717
Score = 46.6 bits (109), Expect = 4e-04
Identities = 36/130 (27%), Positives = 50/130 (38%), Gaps = 8/130 (6%)
Query: 2529 GEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGV------PAAPNRPIAQERSC 2582
GE+ L++ L+ + A N G + S Q P PN P + +
Sbjct: 16420 GELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITR 16479
Query: 2583 TSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVAST--LDTYLVIEDLSPGCPYQF 2640
+SV L W P G C I GY VE + W T T + +E L Y F
Sbjct: 16480 SSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNF 16539
Query: 2641 RVSASNPWGI 2650
R+ A N G+
Sbjct: 16540 RICAINKAGV 16549
Score = 46.6 bits (109), Expect = 4e-04
Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 3/91 (3%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P P + + ++ L+W PP G I GY++E R+ G++ W + + + +
Sbjct: 21486 PGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQ-GNERWVRCNFTDVSECQYTVT 21544
Query: 2631 DLSPGCPYQFRVSASNPWG-ISLPSEPSEFV 2660
LSPG Y+FR+ A N G IS PS+ S +
Sbjct: 21545 GLSPGDRYEFRIIARNAVGTISPPSQSSGII 21575
Score = 46.2 bits (108), Expect = 5e-04
Identities = 32/104 (30%), Positives = 45/104 (43%), Gaps = 3/104 (2%)
Query: 2470 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG 2529
AP F PL V L G T + + G P P ++W Q I S+ S G
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVI---STSTLPGVQISFSDG 61
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPN 2573
L I + +SG Y+ ATN G +++A + V+ A PN
Sbjct: 62 RAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPN 105
Score = 46.2 bits (108), Expect = 5e-04
Identities = 30/110 (27%), Positives = 42/110 (38%), Gaps = 8/110 (7%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVAST--LDTY 2626
P P+ P + S +SV L W P G + GY VE +E + W T
Sbjct: 18631 PGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQ 18690
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSE------PSEFVRLPEYDAAAD 2670
+ L Y FR+ A N G+ P+ E + PE + AD
Sbjct: 18691 FTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDAD 18740
Score = 45.4 bits (106), Expect = 8e-04
Identities = 25/81 (30%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 2585 VILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVAST-LDTYLVIEDLSPGCPYQFRVS 2643
V L+W PP + G I Y +E +E W ++ + D + D+ G QF+V
Sbjct: 7828 VDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVR 7887
Query: 2644 ASNPWGISLPSEPSEFVRLPE 2664
A N G+ PSEP+E + + +
Sbjct: 7888 AENEAGVGHPSEPTEILSIED 7908
Score = 45.4 bits (106), Expect = 8e-04
Identities = 54/224 (24%), Positives = 80/224 (35%), Gaps = 60/224 (26%)
Query: 2496 GRPKP-----------TITWKGPDQN--------ILDTDNSSATYTVSSCDSG--EITLK 2534
GRP P T+ W P+ + L+ +T V S E +K
Sbjct: 12025 GRPDPPEVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPERRMK 12084
Query: 2535 ICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQ---------------- 2578
+ NL+P + A N+ G G P+ P+RP+
Sbjct: 12085 VQNLLPDHEYQFRVKAENEIGI----------GEPSLPSRPVVAKDPIEPPGPPTNFRVV 12134
Query: 2579 ERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQI-----WQQ--SVASTLDTYLVIED 2631
+ + S+ L W P G I GY VE R + + W++ + A + +
Sbjct: 12135 DTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTS 12194
Query: 2632 LSPGCPYQFRVSASNPWGISLPSE------PSEFVRLPEYDAAA 2669
L Y+FRV A N GI P+E P E + PE D A
Sbjct: 12195 LDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDA 12238
Score = 45.4 bits (106), Expect = 8e-04
Identities = 46/155 (29%), Positives = 60/155 (38%), Gaps = 14/155 (9%)
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV------QGVPAAPNRPIAQERSCT 2583
E TLK L + A N G S K Q P P P + + +
Sbjct: 13172 ERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRS 13231
Query: 2584 SVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLD-TYLVIEDLSPGCPYQFR 2641
SV L W P+ G I GY VE + S W + ++ L T + L YQFR
Sbjct: 13232 SVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFR 13291
Query: 2642 VSASNPWGISLPSE------PSEFVRLPEYDAAAD 2670
V A N G S PS+ P + + PE + AD
Sbjct: 13292 VYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDAD 13326
Score = 45.4 bits (106), Expect = 8e-04
Identities = 51/277 (18%), Positives = 107/277 (38%), Gaps = 25/277 (9%)
Query: 2304 QPGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQ 2363
+P + E K N + S++ ++ Y+L+ VS + A N + C
Sbjct: 26788 EPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQC---- 26843
Query: 2364 PASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEAT 2423
S A V + P + S D S++ S S +++M + + ++
Sbjct: 26844 -----SATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSS 26898
Query: 2424 GPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQE------------VAP 2471
++ +S + +S +ES + + ++ M I N ++ + P
Sbjct: 26899 SASSMTEMKFASMSAQSMSSMQESFVE-MSSSSFMGISNMTQLESSTSKMLKAGIRGIPP 26957
Query: 2472 EFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEI 2531
+ D++ G + + C G P P +TW + I + + + + D
Sbjct: 26958 KIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGR--FHIENTDD-LT 27014
Query: 2532 TLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGV 2568
TL I ++ QD G+YT N+ G+ S + + ++ +
Sbjct: 27015 TLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIRSI 27051
Score = 45.1 bits (105), Expect = 0.001
Identities = 30/88 (34%), Positives = 42/88 (47%), Gaps = 3/88 (3%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P +P + SV L+W P G I+GY VE RE W + + + +TY +
Sbjct: 19316 PGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVT 19375
Query: 2631 DLSPGCPYQFRVSASNPWGISLPSEPSE 2658
+L+ Y+FRV A N SEPSE
Sbjct: 19376 ELTEDQRYEFRVFARN--AADSVSEPSE 19401
Score = 44.7 bits (104), Expect = 0.001
Identities = 43/174 (24%), Positives = 71/174 (40%), Gaps = 21/174 (12%)
Query: 2502 ITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATN 2552
++WK PD + I +T + D G T + +L+ + + A N
Sbjct: 9558 LSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAEN 9617
Query: 2553 DHGTTSTSATVK---VQGVPAAPNRPIAQERSC---TSVILRWLPPSSTGNCTISGYTVE 2606
G T++ + P+ PI + +V L W PP + G ++ Y VE
Sbjct: 9618 RFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVE 9677
Query: 2607 ---YREEGS--QIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPS 2654
+ G+ + W+Q + + +EDL G Y+FRV A N G+S PS
Sbjct: 9678 CLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPS 9731
Score = 44.3 bits (103), Expect = 0.002
Identities = 48/199 (24%), Positives = 76/199 (38%), Gaps = 32/199 (16%)
Query: 2487 TVILQCKVCGRPKPT--------------ITWKGPDQN--------ILDTDNSSA-TYTV 2523
T + KV G P P +TW+ P+ + +L+ + TY
Sbjct: 8097 TASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIP 8156
Query: 2524 SSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQE- 2579
+++ + +L+P + A N G V Q P+ P+ E
Sbjct: 8157 VMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEV 8216
Query: 2580 --RSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLD--TYLVIEDLSPG 2635
+ ++ + W PP G I GY +E +G + W++ + TY + L G
Sbjct: 8217 HNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTY-TAKGLEEG 8275
Query: 2636 CPYQFRVSASNPWGISLPS 2654
YQFRV A N GIS PS
Sbjct: 8276 KEYQFRVRAENAAGISEPS 8294
Score = 44.3 bits (103), Expect = 0.002
Identities = 30/88 (34%), Positives = 43/88 (48%), Gaps = 2/88 (2%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P RP A + +V L+W P+ G I+GY VE ++ W + S + L+T +
Sbjct: 18234 PGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVS 18293
Query: 2631 DLSPGCPYQFRVSASNPWG-ISLPSEPS 2657
L Y+FRV A N G S PS+ S
Sbjct: 18294 GLVEDQRYEFRVIARNAAGNFSEPSDSS 18321
Score = 44.3 bits (103), Expect = 0.002
Identities = 30/109 (27%), Positives = 46/109 (42%), Gaps = 4/109 (3%)
Query: 2546 YTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTV 2605
Y A + S + Q AP RP + + ++V L W P+ G + GY +
Sbjct: 22544 YALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGYII 22603
Query: 2606 EYR---EEGSQIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI 2650
E + E G W + + D + + LS G Y+FRV A N G+
Sbjct: 22604 ERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGV 22652
Score = 43.9 bits (102), Expect = 0.002
Identities = 34/119 (28%), Positives = 50/119 (42%), Gaps = 8/119 (6%)
Query: 2550 ATNDHGTTSTSATVKVQGV--PAAPNRPIAQ----ERSCTSVILRWLPPSSTGNCTISGY 2603
A N+ G S ++ + P +P P + + + W PP G I GY
Sbjct: 7888 AENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGY 7947
Query: 2604 TVEYREEGSQIWQQSVASTLD--TYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
VE G++ W + + + + V E + P Y RV A N G+S PSE SE V
Sbjct: 7948 HVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENV 8006
Score = 43.9 bits (102), Expect = 0.002
Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 4/96 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F L + C G +V + +V G P PT+ W+ Q + N +
Sbjct: 25423 PMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHE----GLDY 25478
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
L I + +P+D+G Y ATN G+TS A ++V+
Sbjct: 25479 YALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVE 25514
Score = 43.5 bits (101), Expect = 0.003
Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 2/94 (2%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL--DTY 2626
P P P +++S + L W P S G I GY VE ++ G+ W + L
Sbjct: 11432 PGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCA 11491
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
+ L G Y+FR+ A+N G P E +E V
Sbjct: 11492 FRVPGLIEGNEYRFRIKAANIVGEGEPRELAESV 11525
Score = 43.5 bits (101), Expect = 0.003
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 4/89 (4%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYL 2627
P PI +R+ + L+W P G I+GY VE R+ W + S + ++T
Sbjct: 17151 PPGTPEPIMVKRN--EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQF 17208
Query: 2628 VIEDLSPGCPYQFRVSASNPWG-ISLPSE 2655
+ L+ Y+FRV A N G IS PS+
Sbjct: 17209 TVSGLTEDQRYEFRVIAKNAAGAISKPSD 17237
Score = 43.5 bits (101), Expect = 0.003
Identities = 27/111 (24%), Positives = 45/111 (40%), Gaps = 5/111 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P + L D T K G P+PT W + I Y +S D G
Sbjct: 26480 PVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAI----TQGGKYKLSE-DKGG 26534
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERS 2581
L+I DSG+YTC N G+ S+S + ++ + + ++ +++
Sbjct: 26535 FFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKT 26585
Score = 43.1 bits (100), Expect = 0.004
Identities = 42/167 (25%), Positives = 63/167 (37%), Gaps = 18/167 (10%)
Query: 2501 TITWKGPD--------QNILDTDNSSATY---TVSSCDSGEITLKICNLMPQDSGIYTCI 2549
T+TW P+ Q IL+ +T +S E K+ L + + +
Sbjct: 21797 TLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVM 21856
Query: 2550 ATNDHGTTSTSATVKV------QGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
A N G S ++ P P + S T+V L W P G I GY
Sbjct: 21857 AENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGY 21916
Query: 2604 TVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVSASNPWG 2649
+E + W + + + + T + DL G Y+FRVSA N G
Sbjct: 21917 IIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAG 21963
Score = 42.7 bits (99), Expect = 0.005
Identities = 23/65 (35%), Positives = 31/65 (47%)
Query: 2587 LRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASN 2646
L+W P G I+ Y VE R+ + WQ + DT + L+ G Y FRV+A N
Sbjct: 7730 LKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAEN 7789
Query: 2647 PWGIS 2651
G S
Sbjct: 7790 AIGQS 7794
Score = 42.0 bits (97), Expect = 0.009
Identities = 29/110 (26%), Positives = 52/110 (47%), Gaps = 7/110 (6%)
Query: 2459 EILNPNFIQEVAPEFLV-PLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNS 2517
E+++P+ V P ++ PL D G QC+V G ++W D+ I
Sbjct: 3286 EVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLK-VSWYSKDKKI----KP 3340
Query: 2518 SATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG 2567
S + ++ + L+I P+D G YT +A+N G S++A + ++G
Sbjct: 3341 SRFFRMTQFED-TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEG 3389
Score = 42.0 bits (97), Expect = 0.009
Identities = 29/97 (29%), Positives = 42/97 (43%), Gaps = 5/97 (5%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G V+ C++ G P P I W + I + N S S +L+I N DSG
Sbjct: 26776 GQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSI-----SRSRNVYSLEIRNASVSDSG 26830
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERS 2581
YT A N G S +A++ V + P+R + S
Sbjct: 26831 KYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTS 26867
Score = 40.4 bits (93), Expect = 0.026
Identities = 41/170 (24%), Positives = 65/170 (38%), Gaps = 23/170 (13%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVS----------SCDSGEITLKI--CNLMPQDSGIYTC 2548
TI+W+ P LD S T + S + ++T ++ NL+ + +
Sbjct: 11647 TISWENP----LDNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRV 11702
Query: 2549 IATNDHGTTSTSAT------VKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISG 2602
A N G T T + P P ++ T V L+W P G
Sbjct: 11703 CAENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLS 11762
Query: 2603 YTVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGIS 2651
Y VE R +GS W++ S +T+ +++ Y+FRV N G S
Sbjct: 11763 YHVERRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNEGGES 11812
Score = 40.4 bits (93), Expect = 0.026
Identities = 43/191 (22%), Positives = 74/191 (38%), Gaps = 19/191 (9%)
Query: 2376 VPGSILAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNK 2435
VP S+ LT+ A S S KK+ + + + T E+ + K
Sbjct: 26108 VPRSVFPELTRTEAYAVS--SFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMK 26165
Query: 2436 VSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVC 2495
+ E S EE +T+ +I +A L +T G++ C
Sbjct: 26166 SAALEEKSLEEK-------STTRKIKTT-----LAARILTKPRSMTVYEGESARFSCDTD 26213
Query: 2496 GRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHG 2555
G P PT+TW Q + ++SA + V++ + T +I ++ D G Y+ + N G
Sbjct: 26214 GEPVPTVTWLRKGQVL----STSARHQVTT-TKYKSTFEISSVQASDEGNYSVVVENSEG 26268
Query: 2556 TTSTSATVKVQ 2566
T+ +Q
Sbjct: 26269 KQEAEFTLTIQ 26279
Score = 40.0 bits (92), Expect = 0.035
Identities = 30/105 (28%), Positives = 43/105 (40%), Gaps = 3/105 (2%)
Query: 2468 EVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCD 2527
+V P F+ L +V G + ++ + G P P I W I+ +
Sbjct: 1507 QVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTK-- 1564
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAP 2572
GE LKI + + QDS YT A N G +T V V+ A P
Sbjct: 1565 -GEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEP 1608
Score = 39.3 bits (90), Expect = 0.059
Identities = 27/88 (30%), Positives = 39/88 (44%), Gaps = 1/88 (1%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTY 2626
VP P +E + +V L W PP G I Y +E R G++ + + L
Sbjct: 10344 VPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRK 10403
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPS 2654
++ L G Y++RVSA N G PS
Sbjct: 10404 YTVKGLKEGDTYEYRVSAVNIVGQGKPS 10431
Score = 38.1 bits (87), Expect = 0.13
Identities = 31/110 (28%), Positives = 43/110 (39%), Gaps = 8/110 (7%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQ--QSVASTLDTY 2626
P P P + S +S+ + W P G I+GY VE WQ A T
Sbjct: 15384 PGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATS 15443
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGIS----LPSEPSEFVRL--PEYDAAAD 2670
I L+ Y+ R+ A N G+ +P P R+ PE + AD
Sbjct: 15444 YTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDAD 15493
Score = 37.7 bits (86), Expect = 0.17
Identities = 26/102 (25%), Positives = 45/102 (44%), Gaps = 9/102 (8%)
Query: 2466 IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSS--ATYTV 2523
++ AP + + LG C++ P W + I ++D S ++ +
Sbjct: 4457 VKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYI 4516
Query: 2524 SSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV 2565
SS L+I D G YTC A+N++G+ S +AT+ V
Sbjct: 4517 SS-------LEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4551
Score = 37.4 bits (85), Expect = 0.22
Identities = 35/132 (26%), Positives = 54/132 (40%), Gaps = 9/132 (6%)
Query: 2435 KVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKV 2494
K S ++ SS ES +++ ++ I+E P PLVD GD V L +
Sbjct: 4333 KPSEEKEESSSESGTEEV-ATVKIQEAEGGLIKEDGPMIHTPLVDTVSEEGDIVHLTTSI 4391
Query: 2495 CGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQD-SGIYTCIATND 2553
+ + W ++ + + D TL I + +D G Y C A ND
Sbjct: 4392 TNAKE--VNWYFENKLVPSDEKFKCLQ-----DQNTYTLVIDKVNTEDHQGEYVCEALND 4444
Query: 2554 HGTTSTSATVKV 2565
G T+TSA + V
Sbjct: 4445 SGKTATSAKLTV 4456
Score = 36.6 bits (83), Expect = 0.38
Identities = 48/191 (25%), Positives = 71/191 (37%), Gaps = 26/191 (13%)
Query: 2501 TITWKGPDQN--------ILDTDNSSATYTVSSCDSGEIT---LKICNLMPQDSGIYTCI 2549
T+ W PD + I++ + S + C+ IT L++ L +
Sbjct: 17464 TVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIK-CNKRRITDLRLRVTGLTEDHEYEFRVS 17522
Query: 2550 ATNDHGTTSTS-ATVKVQGV-----PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
A N G S ATV + P P + + S+ L W P G I GY
Sbjct: 17523 AENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGY 17582
Query: 2604 TVEYREEGSQIWQQSVAST--LDTYLVIEDLSPGCPYQFRVSASNPWGI----SLPS--E 2655
VE + + WQ T T I L+ Y+ RV A N G+ S+P +
Sbjct: 17583 VVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVK 17642
Query: 2656 PSEFVRLPEYD 2666
P + + PE D
Sbjct: 17643 PEDKLEAPELD 17653
Score = 36.2 bits (82), Expect = 0.50
Identities = 47/199 (23%), Positives = 71/199 (35%), Gaps = 20/199 (10%)
Query: 2381 LAPLTKATAAESSDGSIKKSCSWHTLRMR---KRAEVENTGKNEATGPRKPKDILGNKVS 2437
L PL TA E S +R++ + T K I +S
Sbjct: 5560 LTPLKDVTAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLS 5619
Query: 2438 VKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGR 2497
+ +T S E + + +L E P F L D T + D VILQC++
Sbjct: 5620 IDDT-SQIRVEAMGMSSEAKLTVL------EGDPYFTGKLQDYTGVEKDEVILQCEISKA 5672
Query: 2498 PKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTT 2557
P + W + I + N+ V D + L + + D G YTC D GT
Sbjct: 5673 DAP-VKWFKDGKEIKPSKNA-----VIKADGKKRMLILKKALKSDIGQYTC----DCGTD 5722
Query: 2558 STSATVKVQGVPAAPNRPI 2576
TS + ++ RP+
Sbjct: 5723 KTSGKLDIEDREIKLVRPL 5741
Score = 35.8 bits (81), Expect = 0.65
Identities = 24/69 (34%), Positives = 33/69 (47%), Gaps = 3/69 (4%)
Query: 2499 KPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTS 2558
KPT K + ++S YT +S G +TL+I + DSG Y + TN G S
Sbjct: 26028 KPTAEVKWYHNGVELQESSKIHYTNTS---GVLTLEILDCHTDDSGTYRAVCTNYKGEAS 26084
Query: 2559 TSATVKVQG 2567
AT+ V G
Sbjct: 26085 DYATLDVTG 26093
Score = 35.4 bits (80), Expect = 0.85
Identities = 29/96 (30%), Positives = 41/96 (42%), Gaps = 7/96 (7%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIED 2631
P +P + + ++V L W P G I GY VE + W + +T + E+
Sbjct: 12821 PGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVR--CNTAPHQIPQEE 12878
Query: 2632 -----LSPGCPYQFRVSASNPWGISLPSEPSEFVRL 2662
L YQFR A IS PSEPS+ V +
Sbjct: 12879 YTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTI 12914
Score = 34.3 bits (77), Expect = 1.9
Identities = 16/26 (61%), Positives = 20/26 (76%)
Query: 2541 QDSGIYTCIATNDHGTTSTSATVKVQ 2566
+DSGI TC ATN +GT TSAT+ V+
Sbjct: 1724 RDSGIITCRATNKYGTDHTSATLIVK 1749
Score = 34.3 bits (77), Expect = 1.9
Identities = 37/147 (25%), Positives = 63/147 (42%), Gaps = 21/147 (14%)
Query: 2434 NKVSVKETN----SSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVI 2489
+K+ +KE S +++ +L +++L E P F V L D T + D +
Sbjct: 5256 HKLEMKEVTLDDISQIKAQVKELSSTAQLKVL------EADPYFTVKLHDKTAVEKDEIT 5309
Query: 2490 LQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
L+C+V + P +K ++ + S Y++ + D LKI +D G Y C
Sbjct: 5310 LKCEV-SKDVPVKWFKDGEEIV-----PSPKYSIKA-DGLRRILKIKKADLKDKGEYVC- 5361
Query: 2550 ATNDHGTTSTSATVKVQGVPAAPNRPI 2576
D GT T A V V+ +P+
Sbjct: 5362 ---DCGTDKTKANVTVEARLIKVEKPL 5385
Score = 33.5 bits (75), Expect = 3.2
Identities = 23/85 (27%), Positives = 39/85 (45%), Gaps = 6/85 (7%)
Query: 2485 GDTVILQCKVCGRPKPT-ITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDS 2543
G V CK+ + T +TW + + +++ TY + G L + ++ D
Sbjct: 25210 GGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITY-----EDGVAILYVKDITKLDD 25264
Query: 2544 GIYTCIATNDHGTTSTSATVKVQGV 2568
G Y C ND+G S+ A + V+GV
Sbjct: 25265 GTYRCKVVNDYGEDSSYAELFVKGV 25289
Score = 32.3 bits (72), Expect = 7.2
Identities = 34/154 (22%), Positives = 61/154 (39%), Gaps = 22/154 (14%)
Query: 2407 RMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFI 2466
R++ V++ + ++ P PK VS ET + + L + P
Sbjct: 26300 RVKSPEAVKSPKRVKSPEPSHPK-----AVSPTETKPTPTEKVQHLPVSAP-----PKIT 26349
Query: 2467 QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
Q + E + +TC++ +V+ R K +TW + + + + Y+
Sbjct: 26350 QFLKAEASKEIAKLTCVVESSVL-------RAKE-VTWYKDGKKLKENGHFQFHYSAD-- 26399
Query: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTS 2560
G LKI NL D G Y C + + GT+ T+
Sbjct: 26400 --GTYELKINNLTESDQGEYVCEISGEGGTSKTN 26431
>gi|110349715 titin isoform N2-B [Homo sapiens]
Length = 26926
Score = 231 bits (588), Expect = 1e-59
Identities = 152/487 (31%), Positives = 240/487 (49%), Gaps = 26/487 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P+ L + V L G+ V ++ G+P P ITW+ Q+++D + S S
Sbjct: 24531 PKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQ-KGQDLIDNNGHYQVIVTRSFTS-- 24587
Query: 2531 ITLKICN-LMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRW 2589
L N + +D+G Y A N G + + V VP P + S SV L W
Sbjct: 24588 --LVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTW 24645
Query: 2590 LPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG 2649
P+S G I+ Y VE ++ W + V +T + +L YQFRV A N +G
Sbjct: 24646 TEPASDGGSKITNYIVEKCATTAERWLR-VGQARETRYTVINLFGKTSYQFRVIAENKFG 24704
Query: 2650 ISLPSEPSE-------FVRLPEYDAAAD---------GATISWKENFDSAYTELNEIGRG 2693
+S PSEPSE R YD D + S KE ++ Y ++GRG
Sbjct: 24705 LSKPSEPSEPTITKEDKTRAMNYDEEVDETREVSMTKASHSSTKELYEK-YMIAEDLGRG 24763
Query: 2694 RFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSY 2753
F IV +C+ +++K KFV K + E ++L +H + LH+++ES
Sbjct: 24764 EFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISILNIARHRNILHLHESFESMEEL 24823
Query: 2754 ILILELMDDGRLLDYLMNHD-ELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLID 2812
++I E + + + + EL E ++ Y+ + EALQ+LH+ + H DI+PEN++
Sbjct: 24824 VMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHFDIRPENIIYQ 24883
Query: 2813 LRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYV 2872
R +K+I+ A Q+ + L PE+ APEV Q VS TD+WS+G L YV
Sbjct: 24884 TRRS-STIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDMWSLGTLVYV 24942
Query: 2873 MLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATC 2932
+LSG++PFL E+ ++ N+ +++F E F +S A DF++ +L ++ + R TA+
Sbjct: 24943 LLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSRMTASEA 25002
Query: 2933 LQHPWLQ 2939
LQHPWL+
Sbjct: 25003 LQHPWLK 25009
Score = 101 bits (251), Expect = 1e-20
Identities = 68/214 (31%), Positives = 93/214 (43%), Gaps = 18/214 (8%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLM 2539
+TC G + + GRP P +TWK + + +TD S T T TL + + M
Sbjct: 22160 ITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTT-----KDRTTLTVKDSM 22214
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPI-AQERSCTSVILRWLPPSSTGNC 2598
DSG Y N G + S TV V G P PI S S +L W P G
Sbjct: 22215 RGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIEVSSVSAESCVLSWGEPKDGGGT 22274
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE--- 2655
I+ Y VE RE G+ WQ +S T + + L+ Y FRVS+ N +G+S P E
Sbjct: 22275 EITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAP 22334
Query: 2656 ---------PSEFVRLPEYDAAADGATISWKENF 2680
PS R Y +A+ +I W+E +
Sbjct: 22335 IIAEHPFVPPSAPTRPEVYHVSANAMSIRWEEPY 22368
Score = 97.4 bits (241), Expect = 2e-19
Identities = 68/211 (32%), Positives = 89/211 (42%), Gaps = 26/211 (12%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
GD + ++ V GRPKPT+TWK DQ + T + T +S L I + DSG
Sbjct: 14583 GDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATST-----ILNINECVRSDSG 14637
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTISGY 2603
Y A N G T++V +P P PI E S V W PP + G IS Y
Sbjct: 14638 PYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNY 14697
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI------------- 2650
VE R+ S W + + + T L+ G YQFRV A N +G+
Sbjct: 14698 VVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANY 14757
Query: 2651 --SLPSEPSEFVRLPEYDAAA-DGATISWKE 2678
+P P P+ A D TISW E
Sbjct: 14758 PFKVPGPPG----TPQVTAVTKDSMTISWHE 14784
Score = 94.4 bits (233), Expect = 2e-18
Identities = 59/186 (31%), Positives = 85/186 (45%), Gaps = 6/186 (3%)
Query: 2469 VAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDS 2528
+ P +P + G+ + ++ V GRP+P I+W + + T + T +S
Sbjct: 17813 IQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATST-- 17870
Query: 2529 GEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVIL 2587
L I D G YT ATN GT + + +V V P P P+ E S V++
Sbjct: 17871 ---VLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVI 17927
Query: 2588 RWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNP 2647
W PP+ TG C IS Y VE R+ + W A+ T + I L G YQFR+ A N
Sbjct: 17928 SWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENR 17987
Query: 2648 WGISLP 2653
+G S P
Sbjct: 17988 YGKSAP 17993
Score = 92.0 bits (227), Expect = 8e-18
Identities = 64/202 (31%), Positives = 91/202 (45%), Gaps = 17/202 (8%)
Query: 2487 TVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIY 2546
T+ L + GRP+P + W+ + + D T S L I N+ DSG Y
Sbjct: 18627 TLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVT-------SSFTMLVIDNVTRFDSGRY 18679
Query: 2547 TCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVE 2606
N+ G+ + V+V P+AP +E SV L W PP G I+ Y VE
Sbjct: 18680 NLTLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVE 18739
Query: 2607 YREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE-- 2664
RE + + + T IE+L GC Y FRV ASN +GI LP+E +E V++ E
Sbjct: 18740 KRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPP 18799
Query: 2665 --------YDAAADGATISWKE 2678
D + ATI W++
Sbjct: 18800 LPPGRVTLVDVTRNTATIKWEK 18821
Score = 91.7 bits (226), Expect = 1e-17
Identities = 61/196 (31%), Positives = 83/196 (42%), Gaps = 27/196 (13%)
Query: 2496 GRPKPTITWKGPDQNI-----LDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIA 2550
GRP PT W PD N+ + T +S +T TV +C+ D+G YT
Sbjct: 21886 GRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRN------------DAGKYTLTV 21933
Query: 2551 TNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREE 2610
N+ G+ S + TVKV P P ++ + S L W P G I Y VE RE
Sbjct: 21934 ENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKREA 21993
Query: 2611 GSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV---------- 2660
+ WQ + DL+ G PY FRVSA N +G+ P E E +
Sbjct: 21994 SRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPR 22053
Query: 2661 RLPEYDAAADGATISW 2676
RL D + A ++W
Sbjct: 22054 RLDVVDTSKSSAVLAW 22069
Score = 90.5 bits (223), Expect = 2e-17
Identities = 85/288 (29%), Positives = 125/288 (43%), Gaps = 34/288 (11%)
Query: 2414 VENTGKNEAT----GPRKPKDILGNKV---SVKETNSSEESECDDLDPNTSMEILNPNFI 2466
VE GK E T G K +I +++ SV E ++E DP T + P +
Sbjct: 21002 VERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVT----IGPITV 21057
Query: 2467 QE--VAPEFL---VPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATY 2521
+E + PE +P VT +G V L+ G+PKP+I+W + +++ +
Sbjct: 21058 KELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESE-----F 21112
Query: 2522 TVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QER 2580
S +ITL I N + G YT I N + TV G P+ P PI E
Sbjct: 21113 VRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKGPIRFDEI 21172
Query: 2581 SCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQF 2640
SVIL W P G I+ Y++E RE W+ +S T + +L YQF
Sbjct: 21173 KADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQF 21232
Query: 2641 RVSASNPWGISLPSEPSEFV-----RLPE-------YDAAADGATISW 2676
RV A N +G+S P S V R+P Y+ +DG +++W
Sbjct: 21233 RVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSLTW 21280
Score = 88.6 bits (218), Expect = 8e-17
Identities = 60/195 (30%), Positives = 85/195 (43%), Gaps = 9/195 (4%)
Query: 2468 EVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTD--NSSATYTVSS 2525
E+ P +P + + + GRP+ T+ W+ Q + +T N S++ TV+S
Sbjct: 18895 EIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTS 18954
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSV 2585
L I +D G Y +N G+ + T+ V P P E SC S+
Sbjct: 18955 -------LSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSI 19007
Query: 2586 ILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSAS 2645
+ W PP G C IS Y VE +E S W + T + I L+ G YQFRV A
Sbjct: 19008 TISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAE 19067
Query: 2646 NPWGISLPSEPSEFV 2660
N +G S SE S V
Sbjct: 19068 NRYGKSSYSESSAVV 19082
Score = 88.2 bits (217), Expect = 1e-16
Identities = 101/420 (24%), Positives = 157/420 (37%), Gaps = 60/420 (14%)
Query: 2422 ATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSM-EILNPNFIQEVAPEFLVPLVDV 2480
ATG + ++ N S SE D P T + E + P VA + L+
Sbjct: 12756 ATGLEEKAQYQFRAIARTAVNISPPSEPSD--PVTILAENVPPRIDLSVAMKSLL----- 12808
Query: 2481 TCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMP 2540
T G V L V G+P PT++WK + + + C TL++ ++
Sbjct: 12809 TVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLC-----TLELFSVNR 12863
Query: 2541 QDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTI 2600
+DSG YT A N G+ S + +KV P P + +L W PP G I
Sbjct: 12864 KDSGDYTITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEI 12923
Query: 2601 SGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
+ Y V+ RE W Q A+ T +E L G YQFR+ A N +G+ P +
Sbjct: 12924 TNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAI 12983
Query: 2661 RLPEYD------------AAADGATISWKENFDSA------------------YTELNEI 2690
YD D T+SWK D +T++N
Sbjct: 12984 AKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRK 13043
Query: 2691 GRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQH----PQYITLHDT 2746
++ + + T + V ++K K A +AA + Q+ P + ++DT
Sbjct: 13044 PIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDT 13103
Query: 2747 YESPTSYILILELMDDGR-LLDYLM-----NHDELME-------EKVAFYIRDIMEALQY 2793
S S D G ++ YL+ + D + +K F + +ME QY
Sbjct: 13104 TRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQY 13163
Score = 87.8 bits (216), Expect = 1e-16
Identities = 60/202 (29%), Positives = 88/202 (43%), Gaps = 17/202 (8%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G ++ L + GRP P + W D I D T + +S L + N+ DSG
Sbjct: 16460 GGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTS-------LVLDNVNRYDSG 16512
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
YT N GT S TV+V P+ P E + SV + W PP G I Y
Sbjct: 16513 KYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYI 16572
Query: 2605 VEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
VE RE + + V + I+ L GC Y FRV+A N +GI LP++ ++ +++ E
Sbjct: 16573 VEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAE 16632
Query: 2665 Y----------DAAADGATISW 2676
D + ++SW
Sbjct: 16633 VPQPPGKITVDDVTRNSVSLSW 16654
Score = 87.4 bits (215), Expect = 2e-16
Identities = 61/204 (29%), Positives = 89/204 (43%), Gaps = 21/204 (10%)
Query: 2487 TVILQCKVCGRPKPTITWKGPDQNILDTDN--SSATYTVSSCDSGEITLKICNLMPQDSG 2544
T+ L + GRP P + W LD + S+++YT+ L + N+ DSG
Sbjct: 15380 TLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTL---------LIVGNVNRFDSG 15430
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
Y N G+ S V+V P P +E + TSV L W PP G I Y
Sbjct: 15431 KYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYI 15490
Query: 2605 VEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
VE RE + + + T ++ L GC Y FRV A N +GI LP+E +E V+ E
Sbjct: 15491 VEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASE 15550
Query: 2665 ----------YDAAADGATISWKE 2678
D + ++SW++
Sbjct: 15551 RPLPPGKITLMDVTRNSVSLSWEK 15574
Score = 85.5 bits (210), Expect = 7e-16
Identities = 74/282 (26%), Positives = 117/282 (41%), Gaps = 36/282 (12%)
Query: 2453 DPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVC--------GRPKPTITW 2504
DP+ S + P +E E PL D+ + T+I++ GRP P + W
Sbjct: 19670 DPSDSSD---PQIAKEREEE---PLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLW 19723
Query: 2505 KGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVK 2564
PD TD + Y V + DS +L I N DSG YT N S + VK
Sbjct: 19724 SKPD-----TDLRTRAY-VDTTDS-RTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVK 19776
Query: 2565 VQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLD 2624
V P P Q+ + S +L W P + G + Y +E RE + W +
Sbjct: 19777 VLDTPGPPTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNR 19836
Query: 2625 TYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDA----------AADGATI 2674
+ +L G Y FRVS N +G+ +P+E E V++ E + + D ++
Sbjct: 19837 LSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSL 19896
Query: 2675 SW-KENFDS----AYTELNEIGRGRFSIVKKCIHKATRKDVA 2711
+W K D + + + +G+ + VK + K+T V+
Sbjct: 19897 TWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVS 19938
Score = 85.1 bits (209), Expect = 9e-16
Identities = 64/238 (26%), Positives = 100/238 (42%), Gaps = 10/238 (4%)
Query: 2484 LGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEIT-LKICNLMPQD 2542
+G + ++ + GRPKPTITW + T + T DS ++T L I D
Sbjct: 16746 VGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVT------DSLDLTTLSIKETHKDD 16799
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTIS 2601
G Y N G + S + P P P+ + S S+ L W PP TG C I+
Sbjct: 16800 GGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQIT 16859
Query: 2602 GYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV- 2660
Y V+ R+ + +W A+ T L + L G YQFR+ A N +G S E V
Sbjct: 16860 NYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVA 16919
Query: 2661 RLPEYDAAADGATISWKENFDSAYTELNE-IGRGRFSIVKKCIHKATRKDVAVKFVSK 2717
+ P + G + + DS + +E + G ++ + + R + V+K
Sbjct: 16920 QYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNK 16977
Score = 84.7 bits (208), Expect = 1e-15
Identities = 64/201 (31%), Positives = 84/201 (41%), Gaps = 15/201 (7%)
Query: 2485 GDTVILQCKVCGRPKPTITW-----KGPDQN--ILDTDNSSATYTVSSCDSGEITLKICN 2537
G V + K+ G P PT+TW K PD +L + + +C TL I
Sbjct: 9634 GTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTC-----TLVIPQ 9688
Query: 2538 LMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTSVILRWLPPSSTG 2596
D+G+YT A N+ GT S + V G P P PI E S + L W PP G
Sbjct: 9689 SRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDG 9748
Query: 2597 NCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP--S 2654
I+ Y +E RE + W + + I L G Y FR+ A N +GI P S
Sbjct: 9749 GSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDS 9808
Query: 2655 EPSEFVRLPEYDAAADGATIS 2675
EP L A D T+S
Sbjct: 9809 EPETARNLFSVPGAPDKPTVS 9829
Score = 84.0 bits (206), Expect = 2e-15
Identities = 54/171 (31%), Positives = 82/171 (47%), Gaps = 10/171 (5%)
Query: 2490 LQCKVCGRPKPTITWK-GPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTC 2548
L+ + G+P P+++WK G D DT S + V++ TL + + D+G YT
Sbjct: 13505 LKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNT------TLIVYDCQKSDAGKYTI 13558
Query: 2549 IATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTISGYTVEY 2607
N GT + ++KV G P P PI E + ++ L+W PP G I+ Y +E
Sbjct: 13559 TLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEK 13618
Query: 2608 REEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI--SLPSEP 2656
R+ + W ++ T + L G Y FRVSA N +G+ L SEP
Sbjct: 13619 RDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEP 13669
Score = 84.0 bits (206), Expect = 2e-15
Identities = 77/295 (26%), Positives = 119/295 (40%), Gaps = 24/295 (8%)
Query: 2398 KKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTS 2457
K S W T K E TG I G + S + + +E+ D S
Sbjct: 15593 KGSDKWATCATVKVTEATITGL-----------IQGEEYSFRVSAQNEKGISDPRQ--LS 15639
Query: 2458 MEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNS 2517
+ ++ + + + P F + T L G+ + + GRP P +TW + + T
Sbjct: 15640 VPVIAKDLV--IPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRV 15697
Query: 2518 SATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA 2577
+A T ++ L I + +D G Y TN G + V V P P P+
Sbjct: 15698 NAESTENNS-----LLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVK 15752
Query: 2578 QER-SCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGC 2636
+ + S+ L W PP G +I+ Y VE R+ + WQ A+ T + L GC
Sbjct: 15753 MDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGC 15812
Query: 2637 PYQFRVSASNPWGIS--LPSEPSEFVRLPEYDAAADGATISWKENFDSAYTELNE 2689
YQFR++A N +G S L SEP+ + P G + + DS + NE
Sbjct: 15813 EYQFRIAAENRYGKSTYLNSEPT-VAQYPFKVPGPPGTPVVTLSSRDSMEVQWNE 15866
Score = 83.6 bits (205), Expect = 3e-15
Identities = 64/209 (30%), Positives = 93/209 (44%), Gaps = 17/209 (8%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G+ V + GRP PT+TW+ ++N+ S A Y++ + DS + L I + D+G
Sbjct: 20789 GEDVQVLIPFKGRPPPTVTWRKDEKNL----GSDARYSIENTDSSSL-LTIPQVTRNDTG 20843
Query: 2545 IYTCIATNDHGTT-STSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
Y N G S++ +VKV PAA + + S +V L W PP G I Y
Sbjct: 20844 KYILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINY 20903
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLP 2663
+E R+ + W T + DLS P+ FRV A N GI P E +E V+
Sbjct: 20904 VIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAA 20963
Query: 2664 EY----------DAAADGATISW-KENFD 2681
E D+ +SW K +FD
Sbjct: 20964 EVPAPIRDLSMKDSTKTSVILSWTKPDFD 20992
Score = 83.2 bits (204), Expect = 4e-15
Identities = 65/227 (28%), Positives = 90/227 (39%), Gaps = 20/227 (8%)
Query: 2470 APEFLVP---LVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
APE + L +T G + L V G+P+P ITW D IL D V
Sbjct: 7190 APEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADM-ILKQDKRITIENVPK- 7247
Query: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVI 2586
+ T+ I + D+G Y A N G + V V P P + + S +
Sbjct: 7248 ---KSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCL 7304
Query: 2587 LRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASN 2646
L W PP G I+ Y VE R S++W + ++ DT L P Y FRV+A N
Sbjct: 7305 LTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAEN 7364
Query: 2647 PWGISLPSE------------PSEFVRLPEYDAAADGATISWKENFD 2681
+G+ P + P RL D D T++W E D
Sbjct: 7365 MYGVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDD 7411
Score = 82.8 bits (203), Expect = 5e-15
Identities = 67/221 (30%), Positives = 91/221 (41%), Gaps = 18/221 (8%)
Query: 2480 VTCLLGDTVILQC-KVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNL 2538
+T GDT++L + G+P P +W ++I +D + T T +S +T+K
Sbjct: 13891 LTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTS---SMLTIKYATR 13947
Query: 2539 MPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNC 2598
+D+G YT ATN GT V V VP P S L W PP G
Sbjct: 13948 --KDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGS 14005
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP--SEP 2656
I Y +E RE +W V L G Y FRVSA N +G P SEP
Sbjct: 14006 PIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEP 14065
Query: 2657 SEFV---------RLPEY-DAAADGATISWKENFDSAYTEL 2687
+ V PE + + AT+SWK D +E+
Sbjct: 14066 VKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEI 14106
Score = 82.4 bits (202), Expect = 6e-15
Identities = 57/234 (24%), Positives = 101/234 (43%), Gaps = 18/234 (7%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLM 2539
+T +G+ L + G+PKP ++W + ++L+ D + T ++ +I K
Sbjct: 10331 LTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAK----- 10385
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNC 2598
DSG Y + N G+ V V P P P++ E + +++ W PP G
Sbjct: 10386 RSDSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVTKDYMVISWKPPLDDGGS 10445
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP----- 2653
I+ Y +E +E G +W +++ T + L G Y FR+ A N +GIS P
Sbjct: 10446 KITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDS 10505
Query: 2654 SEPSEFVRLPE-------YDAAADGATISWKENFDSAYTELNEIGRGRFSIVKK 2700
+ + R+P+ + D A ++W + D N I R ++ K+
Sbjct: 10506 MKAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKPITNYILEKRETMSKR 10559
Score = 80.5 bits (197), Expect = 2e-14
Identities = 59/199 (29%), Positives = 88/199 (44%), Gaps = 8/199 (4%)
Query: 2467 QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
Q + P+ L+P +T G + ++ V G+P PT WK + ++ +S+ V
Sbjct: 12399 QLLPPKILMP-EQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVV----TSSHLAVHKA 12453
Query: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPI-AQERSCTSV 2585
DS I + I ++ +DSG Y+ A N GT + V V P P P + +
Sbjct: 12454 DSSSILI-IKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADAC 12512
Query: 2586 ILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSAS 2645
L W P G I+ Y VE + W ++AS T + L PG Y FRV A
Sbjct: 12513 SLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAE 12572
Query: 2646 NPWGISLP-SEPSEFVRLP 2663
N +GIS P + P + P
Sbjct: 12573 NRFGISEPLTSPKMVAQFP 12591
Score = 78.2 bits (191), Expect = 1e-13
Identities = 63/207 (30%), Positives = 92/207 (44%), Gaps = 22/207 (10%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSA-TYT-VSSCDSGEITLKICNLMPQD 2542
G V L + GRP P +W + +++ + T+T V+ E T++ D
Sbjct: 23256 GRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIR-------D 23308
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTIS 2601
+G YT N GTTS + V + P P PI E TS+ + W PP G +S
Sbjct: 23309 TGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLS 23368
Query: 2602 GYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGIS--LPSEPSE- 2658
GY VE R+ W S + L+ G Y FRV+A+N +GI L SE E
Sbjct: 23369 GYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIEC 23428
Query: 2659 --FVRLPE-------YDAAADGATISW 2676
+R+P +D + DG T++W
Sbjct: 23429 RSSIRIPGPPETLQIFDVSRDGMTLTW 23455
Score = 77.0 bits (188), Expect = 3e-13
Identities = 59/204 (28%), Positives = 79/204 (38%), Gaps = 15/204 (7%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G T+ L V GRP P ITW P+ N+ D + S D + L+ N+ D+G
Sbjct: 13211 GVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLD----IKSTDF-DTFLRCENVNKYDAG 13265
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
Y N G + VKV P P +E S S + W PP G I Y
Sbjct: 13266 KYILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYV 13325
Query: 2605 VEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE--------- 2655
V+ R+ + W T + +L G Y FRV A N +GI P E
Sbjct: 13326 VQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQ 13385
Query: 2656 -PSEFVRLPEYDAAADGATISWKE 2678
P V L + +I WK+
Sbjct: 13386 TPGPVVDLKVRSVSKSSCSIGWKK 13409
Score = 77.0 bits (188), Expect = 3e-13
Identities = 61/216 (28%), Positives = 85/216 (39%), Gaps = 17/216 (7%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G+T +L+ + G+P P + W + + +T +A + S + TL + + + D G
Sbjct: 18225 GETFVLEADIRGKPIPDVVWSKDGKELEET---AARMEIKSTIQ-KTTLVVKDCIRTDGG 18280
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTSVILRWLPPSSTGNCTISGY 2603
Y +N GT S TVKV P P P+ + L W PP G IS Y
Sbjct: 18281 QYILKLSNVGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHY 18340
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE-------- 2655
+E RE W Q + L PG Y FRV A N +GI P E
Sbjct: 18341 IIEKRETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACN 18400
Query: 2656 ---PSEFVRLPEYDA-AADGATISWKENFDSAYTEL 2687
P PE A D ++W D TE+
Sbjct: 18401 PYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEI 18436
Score = 76.3 bits (186), Expect = 4e-13
Identities = 54/187 (28%), Positives = 74/187 (39%), Gaps = 3/187 (1%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLM 2539
+T GDT+ L+ V G+P P + W D++ D S + DS + +L
Sbjct: 11714 LTVKAGDTIRLEAGVRGKPFPEVAWT-KDKDATDLTRSPRVKIDTRADSSKFSLT--KAK 11770
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCT 2599
D G Y ATN G+ ATV V P + S + W PP G C
Sbjct: 11771 RSDGGKYVVTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWDPPEDDGGCE 11830
Query: 2600 ISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF 2659
I Y +E E +W A+ L + L G Y FRV A N G P+E
Sbjct: 11831 IQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPPTESKPV 11890
Query: 2660 VRLPEYD 2666
+ +YD
Sbjct: 11891 IAKTKYD 11897
Score = 75.9 bits (185), Expect = 6e-13
Identities = 60/199 (30%), Positives = 78/199 (39%), Gaps = 14/199 (7%)
Query: 2476 PLVDVTCLLGDTVIL--------QCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCD 2527
P + V DTVIL + V GRP PT+ W + + T A + D
Sbjct: 14962 PKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGT----AKLEIKIAD 15017
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVI 2586
L + +DSG YT ATN G VKV P P P+A E + +
Sbjct: 15018 FST-NLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEKCV 15076
Query: 2587 LRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASN 2646
L W PP G I Y V+ RE W + T L + L G Y FRV A N
Sbjct: 15077 LSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVN 15136
Query: 2647 PWGISLPSEPSEFVRLPEY 2665
+G+ P E + + Y
Sbjct: 15137 KYGVGEPLESEPVLAVNPY 15155
Score = 75.9 bits (185), Expect = 6e-13
Identities = 53/195 (27%), Positives = 76/195 (38%), Gaps = 21/195 (10%)
Query: 2496 GRPKPTITWKGPDQNILDTDN--SSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATND 2553
GRP P ITW + D YT S D N D+G Y N
Sbjct: 17553 GRPTPEITWSREEGEFTDKVQIEKGVNYTQLSID---------NCDRNDAGKYILKLENS 17603
Query: 2554 HGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQ 2613
G+ S TVKV P P +E S L W PP G + Y ++ RE +
Sbjct: 17604 SGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRK 17663
Query: 2614 IWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE--------- 2664
+ + T +E+L+ G Y FRV A N +G+ +P E + V+ E
Sbjct: 17664 AYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVT 17723
Query: 2665 -YDAAADGATISWKE 2678
D + A++ W++
Sbjct: 17724 LTDVSQTSASLMWEK 17738
Score = 75.5 bits (184), Expect = 7e-13
Identities = 52/180 (28%), Positives = 73/180 (40%), Gaps = 18/180 (10%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNI-----LDTDNSSATYTVSSCDSGEITLKICNLM 2539
G + L + G+P P W Q+I + T + + D G
Sbjct: 23654 GGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRG---------- 23703
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTSVILRWLPPSSTGNC 2598
DSG Y + N G + V+V G P +P P+ + SV + W PP+ G
Sbjct: 23704 --DSGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGA 23761
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
I GY +E RE W + T LV++ L Y FRVSA N +GIS P + E
Sbjct: 23762 DILGYILERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEE 23821
Score = 75.1 bits (183), Expect = 1e-12
Identities = 63/237 (26%), Positives = 100/237 (42%), Gaps = 19/237 (8%)
Query: 2454 PNTSMEILNPNFIQEVAPEFLVPLVD-VTCLLGDTVILQCKVCGRPKPTITWKGPDQNIL 2512
P+T++ I + + E V L++ + G TV + G P PT W D + +
Sbjct: 10996 PDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWT-TDGSEI 11054
Query: 2513 DTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAP 2572
TD YTV + D+ L I N + +D+G Y +N G+ + + + V VP P
Sbjct: 11055 KTDEH---YTVET-DNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPP 11110
Query: 2573 NRPI-AQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIED 2631
PI + + + + W PP G + Y VE ++ W + + T L I
Sbjct: 11111 TGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPH 11170
Query: 2632 LSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEY------------DAAADGATISW 2676
L GC Y FRV A N G+ P + + V ++ D + AT+SW
Sbjct: 11171 LQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSW 11227
Score = 74.3 bits (181), Expect = 2e-12
Identities = 62/214 (28%), Positives = 86/214 (40%), Gaps = 27/214 (12%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITW--KGPD---QNILDTDNSSATYTVSSCDSGEITLK 2534
VT G ++ L V GRP P ITW +G D + I+DT S + V +
Sbjct: 22959 VTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNR------ 23012
Query: 2535 ICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSS 2594
D+G YT A N G S + VKV P +E S SV + W P+
Sbjct: 23013 ------YDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTI 23066
Query: 2595 TGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPS 2654
G ++ Y VE RE + ++ T I L G Y FRV N +GI P
Sbjct: 23067 DGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPC 23126
Query: 2655 EPSEFV----------RLPEYDAAADGATISWKE 2678
E S+ V +L D T++W++
Sbjct: 23127 ETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEK 23160
Score = 73.9 bits (180), Expect = 2e-12
Identities = 61/206 (29%), Positives = 83/206 (40%), Gaps = 20/206 (9%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G+T L+ V G+P PTI W D+ I SA + + D + + + + + D G
Sbjct: 17143 GETFRLEADVHGKPLPTIEWLRGDKEI----EESARCEIKNTDFKALLI-VKDAIRIDGG 17197
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTS--VILRWLPPSSTGNCTISG 2602
Y A+N G+ S VKV P P P+ Q TS L W PP G IS
Sbjct: 17198 QYILRASNVAGSKSFPVNVKVLDRPGPPEGPV-QVTGVTSEKCSLTWSPPLQDGGSDISH 17256
Query: 2603 YTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE------- 2655
Y VE RE W + + L + L G Y FR+ A N +G+ P E
Sbjct: 17257 YVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMK 17316
Query: 2656 -----PSEFVRLPEYDAAADGATISW 2676
P L + A D T+ W
Sbjct: 17317 NPFVLPGPPKSLEVTNIAKDSMTVCW 17342
Score = 73.6 bits (179), Expect = 3e-12
Identities = 61/271 (22%), Positives = 100/271 (36%), Gaps = 46/271 (16%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNS-------------------------SA 2519
GD + L + G P PTITW D+N++ + +
Sbjct: 8197 GDEIALDASISGSPYPTITWI-KDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQ 8255
Query: 2520 TYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQE 2579
++ + GE L++ + + D G+Y NDHG TV V P P + ++
Sbjct: 8256 RLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPINFVFED 8315
Query: 2580 RSCTSVILRWLPPSSTGNCTISGYTVEYRE--EGSQIWQQSVASTLDTYLVIEDLSPGCP 2637
TSV+ +W PP G I YT+E ++ + W ++ + L G
Sbjct: 8316 IRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKE 8375
Query: 2638 YQFRVSASNPWGISLPSEPSEFVRLPEY------------DAAADGATISWKENFDSA-- 2683
Y FRV A N +G P V + D ++ + W E D+
Sbjct: 8376 YLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNGSP 8435
Query: 2684 ----YTELNEIGRGRFSIVKKCIHKATRKDV 2710
+ E E+ +S V K + A + +V
Sbjct: 8436 ILGYWLEKREVNSTHWSRVNKSLLNALKANV 8466
Score = 72.8 bits (177), Expect = 5e-12
Identities = 64/221 (28%), Positives = 95/221 (42%), Gaps = 21/221 (9%)
Query: 2444 SEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTC-------LLGDTVILQCKVCG 2496
S E++ DP+ EIL P + F+ P +D++ ++ + + + G
Sbjct: 6870 SAENKAGVSDPS---EILGPLTADDA---FVEPTMDLSAFKDGLEVIVPNPITILVPSTG 6923
Query: 2497 RPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT 2556
P+PT TW D+ +L+T + T+S+ L I D GIYT N T
Sbjct: 6924 YPRPTATWCFGDK-VLETGDRVKMKTLSAYAE----LVISPSERSDKGIYTLKLENRVKT 6978
Query: 2557 TSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQ 2616
S V V P+AP + + SV L W PP G ++GY VE RE + W
Sbjct: 6979 ISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWT 7038
Query: 2617 QSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPS 2657
+ + D + DL G Y F+V A N G P EP+
Sbjct: 7039 KVMDFVTDLEFTVPDLVQGKEYLFKVCARNKCG---PGEPA 7076
Score = 72.8 bits (177), Expect = 5e-12
Identities = 54/180 (30%), Positives = 74/180 (41%), Gaps = 12/180 (6%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G++ + + G+P PTI W DQ + +T A + S D +L + + + DSG
Sbjct: 16061 GESFKVDADIYGKPIPTIQWIKGDQELSNT----ARLEIKSTDFAT-SLSVKDAVRVDSG 16115
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA----QERSCTSVILRWLPPSSTGNCTI 2600
Y A N G S + VKV P P P+ CT L W PP G I
Sbjct: 16116 NYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCT---LAWKPPLQDGGSDI 16172
Query: 2601 SGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
Y VE RE +W A+ + L G Y FR+ A N +G+ P E V
Sbjct: 16173 INYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVV 16232
Score = 72.0 bits (175), Expect = 8e-12
Identities = 44/168 (26%), Positives = 74/168 (44%), Gaps = 6/168 (3%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G + + + G+P P +T + T + T + +T+ + + D+G
Sbjct: 19994 GSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAEN-----LTINLKESVTADAG 20048
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA-QERSCTSVILRWLPPSSTGNCTISGY 2603
Y A N GTT + V P P P+ + + SV L+W PP G ++ Y
Sbjct: 20049 RYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNY 20108
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGIS 2651
+ RE + +W + A+ T + + L+ G YQFR+ A N +GIS
Sbjct: 20109 ILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAENRFGIS 20156
Score = 71.6 bits (174), Expect = 1e-11
Identities = 63/231 (27%), Positives = 91/231 (39%), Gaps = 23/231 (9%)
Query: 2459 EILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSS 2518
EIL P I A + +V C + L V GRP P +TW+ + DN
Sbjct: 12102 EILEPPEIDLDASMRKLVIVRAGC----PIRLFAIVRGRPAPKVTWRK-----VGIDNVV 12152
Query: 2519 ATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQ 2578
V D+ L I N DSG Y+ N G + V+V P +
Sbjct: 12153 RKGQVDLVDTMAF-LVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVS 12211
Query: 2579 ERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPY 2638
+ + TS + W PP + G ++ Y VE RE + W T + +L PG Y
Sbjct: 12212 DVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEY 12271
Query: 2639 QFRVSASNPWGISLP-------------SEPSEFVRLPEYDAAADGATISW 2676
FRV+A N +G +P SEP +L + + AT++W
Sbjct: 12272 YFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAW 12322
Score = 71.6 bits (174), Expect = 1e-11
Identities = 48/177 (27%), Positives = 76/177 (42%), Gaps = 6/177 (3%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G +V L+ + G+P PTI W D+ + ++ ++ D I +K + + +SG
Sbjct: 20390 GTSVKLRAGISGKPAPTIEWYKDDKEL---QTNALVCVENTTDLASILIKDADRL--NSG 20444
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTSVILRWLPPSSTGNCTISGY 2603
Y N G+ S + V++ P P PI + + + L W PP+ G I+ Y
Sbjct: 20445 CYELKLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHY 20504
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
VE RE +W + + + G Y FRV A N +GI P E V
Sbjct: 20505 IVEKRETSRVVWSMVSEHLEECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVV 20561
Score = 71.2 bits (173), Expect = 1e-11
Identities = 67/221 (30%), Positives = 97/221 (43%), Gaps = 29/221 (13%)
Query: 2364 PASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHTLR---MRKRAE------- 2413
P ++H A + GS +A L K +A SS I KS T++ R RAE
Sbjct: 778 PKTEHGYEAS--IAGSAIATLQKELSATSSAQKITKSVKAPTVKPSETRVRAEPTPLPQF 835
Query: 2414 ----VENTGKNEATGPRKPKDILGNKVSVKETNSSEES----ECDDLDPNTSMEILNPNF 2465
+T K+EA G K++ VS+ T EE + + + P
Sbjct: 836 PFADTPDTYKSEA-GVEVKKEV---GVSITGTTVREERFEVLHGREAKVTETARVPAPVE 891
Query: 2466 IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSS 2525
I P + L +VT + G++V L+C + G P PT+TW D I + + T+
Sbjct: 892 IPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF---- 947
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
SG L I +DSG +TC A N+ GT STS + VQ
Sbjct: 948 -QSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 987
Score = 70.9 bits (172), Expect = 2e-11
Identities = 50/166 (30%), Positives = 69/166 (41%), Gaps = 7/166 (4%)
Query: 2484 LGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDS 2543
+GDT+ L + G P P +TWK D++ T S L+I N +D
Sbjct: 10735 VGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSK-------LEIRNAAHEDG 10787
Query: 2544 GIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
GIY+ N G+ + S V V P P E S L W P G I+ Y
Sbjct: 10788 GIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNY 10847
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG 2649
VE R+ S W A++ + L+ G Y FRV+A N +G
Sbjct: 10848 VVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYG 10893
Score = 70.5 bits (171), Expect = 2e-11
Identities = 61/253 (24%), Positives = 104/253 (41%), Gaps = 24/253 (9%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G + + V G+P PT+TW ++ L + + T +SS ++ I N G
Sbjct: 10042 GGVIRIIAYVSGKPPPTVTWN-MNERTLPQEATIETTAISS------SMVIKNCQRSHQG 10094
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRP-IAQERSCTSVILRWLPPSSTGNCTISGY 2603
+Y+ +A N+ G + V V VP P +A + S L W P G I+ Y
Sbjct: 10095 VYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNY 10154
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF---- 2659
+E RE + W + ++ L G Y FR++A N G+ E SE
Sbjct: 10155 VIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIR 10214
Query: 2660 --VRLPE-------YDAAADGATISWK-ENFDSAYTELNEIGRGRFSIVKKCIHKATRKD 2709
+ +PE + + T++W +D +N + R +K HK T +
Sbjct: 10215 EPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEK-FHKVTNDN 10273
Query: 2710 -VAVKFVSKKMKK 2721
++ K+ K +K+
Sbjct: 10274 LLSRKYTVKGLKE 10286
Score = 68.9 bits (167), Expect = 7e-11
Identities = 63/245 (25%), Positives = 94/245 (38%), Gaps = 36/245 (14%)
Query: 2429 KDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLL---G 2485
K++ + VK N + ESE D T+ EI + +E PE + + CL+ G
Sbjct: 9275 KELRKYRFRVKAVNEAGESEPSD----TTGEIPATDIQEE--PEVFIDIGAQDCLVCKAG 9328
Query: 2486 DTVILQCKVCGRPKPTITWKG---------------PDQNILDTDNSSATYTVSSCDSGE 2530
+ + + GRP P +W+ P+ L+T +S+ + C
Sbjct: 9329 SQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSH 9388
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWL 2590
+G Y+ A N G + + VKV VP P + + S L W
Sbjct: 9389 ------------TGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWK 9436
Query: 2591 PPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI 2650
P G I GY +E R + W + T V+ DL Y FRV A N +GI
Sbjct: 9437 MPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGI 9496
Query: 2651 SLPSE 2655
P E
Sbjct: 9497 GPPVE 9501
Score = 68.6 bits (166), Expect = 9e-11
Identities = 56/181 (30%), Positives = 83/181 (45%), Gaps = 10/181 (5%)
Query: 2484 LGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQD- 2542
+G T+ L GRP P +TW + + +++N + T L + N+ +
Sbjct: 24145 VGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTH-----LVMKNVQRKTH 24199
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSC-TSVILRWLPPSSTGNCTIS 2601
+G Y +N GT V++Q P P PI E S ++ W PP+ G I+
Sbjct: 24200 AGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWIT 24259
Query: 2602 GYTVEYRE--EGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF 2659
Y VE E EG++ WQ ++ T I +L+ Y FRVSA N +GIS P E S
Sbjct: 24260 NYVVEKCEAKEGAE-WQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSV 24318
Query: 2660 V 2660
V
Sbjct: 24319 V 24319
Score = 68.2 bits (165), Expect = 1e-10
Identities = 44/153 (28%), Positives = 70/153 (45%), Gaps = 6/153 (3%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGV-----P 2569
+ S ++T S + + K+ L+P + I+ +A N +G + V P
Sbjct: 18346 ETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPP 18405
Query: 2570 AAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLV 2628
P+ P + S+++ W P G I GY +E R++ W + TL D L
Sbjct: 18406 GPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLR 18465
Query: 2629 IEDLSPGCPYQFRVSASNPWGISLPSEPSEFVR 2661
+ L+ G Y+FRV+A N G+ PSEPS F R
Sbjct: 18466 VTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYR 18498
Score = 67.8 bits (164), Expect = 2e-10
Identities = 67/259 (25%), Positives = 106/259 (40%), Gaps = 29/259 (11%)
Query: 2435 KVSVKETNSSEESECDDLDPNTSMEILNPNFIQ-EVAPEFLVPLVDVTCLLGDTVILQCK 2493
K+ V N++ E + P T E P ++ +V+ + + + + G T+ +
Sbjct: 8576 KLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQI-----MAGKTLRIPAV 8630
Query: 2494 VCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATND 2553
V GRP PT W ++ LD D V + L I + + +D G Y ATN
Sbjct: 8631 VTGRPVPTKVWT-KEEGELDKDR-----VVIDNVGTKSELIIKDALRKDHGRYVITATNS 8684
Query: 2554 HGTTSTSATVKVQGV--PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEG 2611
G+ +A V+V V P +P+ R +L W P G I+G+ +E ++
Sbjct: 8685 CGSKFAAARVEVFDVPGPVLDLKPVVTNRK--MCLLNWSDPEDDGGSEITGFIIERKDAK 8742
Query: 2612 SQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE------------PSEF 2659
W+Q + T + I L G Y+FRV A N +G P E P+
Sbjct: 8743 MHTWRQPI-ETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSP 8801
Query: 2660 VRLPEYDAAADGATISWKE 2678
RL + T+ WKE
Sbjct: 8802 ERLTYTERTKSTITLDWKE 8820
Score = 67.8 bits (164), Expect = 2e-10
Identities = 51/205 (24%), Positives = 85/205 (41%), Gaps = 30/205 (14%)
Query: 2487 TVILQCKVCGRPKP---------------TITWKGPDQN---------ILDTDNSSATYT 2522
+V + CKV +P P +++W P ++ + + S +T
Sbjct: 19375 SVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRETSHLAWT 19434
Query: 2523 VSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG-----VPAAPNRPIA 2577
+ + + K+ L+ + I+ N +G +V ++ VP+ P
Sbjct: 19435 ICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEI 19494
Query: 2578 QERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGC 2636
+ S+ L W P S G ISGY +E RE+ S W + + D + L GC
Sbjct: 19495 TSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGC 19554
Query: 2637 PYQFRVSASNPWGISLPSEPSEFVR 2661
Y++RV A N G+SLPSE S +R
Sbjct: 19555 EYEYRVYAENAAGLSLPSETSPLIR 19579
Score = 67.4 bits (163), Expect = 2e-10
Identities = 52/181 (28%), Positives = 69/181 (38%), Gaps = 5/181 (2%)
Query: 2480 VTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLM 2539
VT G ++L V G+P+P I W D+ + + S YT + +K C+
Sbjct: 22560 VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATA---VIKFCDR- 22615
Query: 2540 PQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCT 2599
DSG YT N GT + S VKV P + + L W P G
Sbjct: 22616 -SDSGKYTLTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAE 22674
Query: 2600 ISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF 2659
I+ Y VE RE W V+ L Y FRV A N +G +P E
Sbjct: 22675 ITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPI 22734
Query: 2660 V 2660
V
Sbjct: 22735 V 22735
Score = 66.6 bits (161), Expect = 3e-10
Identities = 56/211 (26%), Positives = 88/211 (41%), Gaps = 10/211 (4%)
Query: 2467 QEVAPEFLVPLVDVTCLL---GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTV 2523
+E+AP+F + L+ G ++ + + GRP P +TW + N+ + N T +
Sbjct: 14273 REMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESF 14332
Query: 2524 SSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCT 2583
+ + + CN D+G + N G S V+V P + +
Sbjct: 14333 TL-----LIIPECNRY--DTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKD 14385
Query: 2584 SVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVS 2643
SV L W P G I+ Y VE RE + + + + LS GC Y FRV
Sbjct: 14386 SVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVM 14445
Query: 2644 ASNPWGISLPSEPSEFVRLPEYDAAADGATI 2674
A N +GI P+E +E V+ E + D I
Sbjct: 14446 AENEYGIGEPTETTEPVKASEAPSPPDSLNI 14476
Score = 65.9 bits (159), Expect = 6e-10
Identities = 55/212 (25%), Positives = 90/212 (42%), Gaps = 18/212 (8%)
Query: 2479 DVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNL 2538
D+ + G+ + + P PT++W + + +D + D L++
Sbjct: 7898 DIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKN-----DHISAHLEVPKS 7952
Query: 2539 MPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNC 2598
+ D+GIYT N G+ + S VKV G+P A + + +S L W PP G
Sbjct: 7953 VRADAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGT 8012
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG----ISL-- 2652
I Y +E RE G + + ++ ++DL P Y FRV A N G I L
Sbjct: 8013 PILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKN 8072
Query: 2653 ------PSEPSE-FVRLPEYDAAADGATISWK 2677
P +P + V + ++ A+ TI+WK
Sbjct: 8073 PVIAQDPKQPPDPPVDVEVHNPTAEAMTITWK 8104
Score = 65.5 bits (158), Expect = 8e-10
Identities = 46/138 (33%), Positives = 68/138 (49%), Gaps = 8/138 (5%)
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTS--TSATVKVQG---VPAAPNRPIAQERSC 2582
S + T K+ L+ I+ A N +G + S ++K + VP AP++PI E +
Sbjct: 10469 SAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTK 10528
Query: 2583 TSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLV--IEDLSPGCPYQF 2640
S ++ W P G I+ Y +E RE S+ W + + Y + DL GC Y+F
Sbjct: 10529 DSALVTWNKPHDGGK-PITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEF 10587
Query: 2641 RVSASNPWGISLPSEPSE 2658
RVSA N GI PS PS+
Sbjct: 10588 RVSAENEIGIGDPSPPSK 10605
Score = 65.5 bits (158), Expect = 8e-10
Identities = 46/173 (26%), Positives = 76/173 (43%), Gaps = 15/173 (8%)
Query: 2501 TITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIAT 2551
T+ W+ P + +L + S+A +T S +K+ L + + A
Sbjct: 20091 TLKWEPPKYDGGSQVTNYILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAE 20150
Query: 2552 NDHGTT----STSATVKVQ-GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVE 2606
N G + S TVK+ P P+ P + S+ + W P S G + GY +E
Sbjct: 20151 NRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSAVVGYHLE 20210
Query: 2607 YREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
++ S +WQ++ + T+ + +S G Y+FRV A N G+ PS PSE
Sbjct: 20211 MKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSHPSE 20263
Score = 65.1 bits (157), Expect = 1e-09
Identities = 46/171 (26%), Positives = 74/171 (43%), Gaps = 5/171 (2%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILD--TDNSSATYTVSSCDSGEITLKICNLMPQD 2542
G+ V + V G P P I W ++ +++ TD T S + L I + +D
Sbjct: 8916 GEPVHIPADVTGLPMPKIEWS-KNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVRED 8974
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISG 2602
G YT A+N G+ + V+V P+ P + S L W P G I+
Sbjct: 8975 KGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAPLDNGGSEITH 9034
Query: 2603 YTVEYREEGSQ--IWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGIS 2651
Y ++ R+ + W++ + ++ I L P Y+FRV A N +GIS
Sbjct: 9035 YVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGIS 9085
Score = 64.7 bits (156), Expect = 1e-09
Identities = 53/183 (28%), Positives = 75/183 (40%), Gaps = 30/183 (16%)
Query: 2502 ITWKGPDQNILDTDNSSAT-YTVSSCDSG-------EIT-------LKICNLMPQDSGIY 2546
+TW P LD S T Y + D+ E+T I L+P +
Sbjct: 9019 LTWDAP----LDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEF 9074
Query: 2547 TCIATNDHGTTSTSATVKV-----QGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTIS 2601
A N +G + + KV +P P +P R+ S+++ W PP G I+
Sbjct: 9075 RVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPIT 9134
Query: 2602 GYTVEYREEGSQIWQQSVASTL------DTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
GY +E REEGS W + + + + L G YQFR A N GI PSE
Sbjct: 9135 GYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSE 9194
Query: 2656 PSE 2658
PS+
Sbjct: 9195 PSD 9197
Score = 64.7 bits (156), Expect = 1e-09
Identities = 31/91 (34%), Positives = 49/91 (53%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYL 2627
+P+ P++P + T++ + W+ P G I+GYTVEY++ W+ S+ S T
Sbjct: 19586 LPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEY 19645
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
I L+ G Y FRV + N G S PS+ S+
Sbjct: 19646 TISGLTTGAEYVFRVKSVNKVGASDPSDSSD 19676
Score = 64.3 bits (155), Expect = 2e-09
Identities = 36/108 (33%), Positives = 54/108 (50%), Gaps = 1/108 (0%)
Query: 2558 STSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ 2617
S AT + P P P + + +S L W PP G ++GY VEY+EEG + W++
Sbjct: 9913 SDPATARDPIAPPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEK 9972
Query: 2618 SVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
+ T LV+ L G Y+FRV A N GI P E ++ + + +
Sbjct: 9973 GKDKEVRGTKLVVTGLKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKD 10020
Score = 64.3 bits (155), Expect = 2e-09
Identities = 46/172 (26%), Positives = 72/172 (41%), Gaps = 6/172 (3%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G+ + + + GRP P I+W ++ ++ + + T +S+ + +T+K C + +D+G
Sbjct: 19307 GEVLKINADIAGRPLPVISWA---KDGIEIEERARTEIISTDNHTLLTVKDC--IRRDTG 19361
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPI-AQERSCTSVILRWLPPSSTGNCTISGY 2603
Y N GT S + KV P P P+ + L W P G I Y
Sbjct: 19362 QYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYY 19421
Query: 2604 TVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
VE RE W T + L G Y FRV+ N +G+ P E
Sbjct: 19422 IVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLE 19473
Score = 63.5 bits (153), Expect = 3e-09
Identities = 68/267 (25%), Positives = 107/267 (40%), Gaps = 32/267 (11%)
Query: 2466 IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSS 2525
I E PE+ L+ + G+++ ++ V GRP P +TW I N T +
Sbjct: 21460 IVEFGPEYFDGLIIKS---GESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVL-- 21514
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER-SCTS 2584
G +L + + G+YT A N G+ VKVQ P PI +
Sbjct: 21515 ---GSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEK 21571
Query: 2585 VILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVS 2643
+ L W P + G I+ Y +E RE W +Y I+ L G YQFRVS
Sbjct: 21572 MTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIK-LINGNEYQFRVS 21630
Query: 2644 ASNPWGISLPSEPSEFVRLPEY------------DAAADGATISWKENFDSAYTELNEIG 2691
A N +G+ P + V +Y + + T++W +E+ +
Sbjct: 21631 AVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQY- 21689
Query: 2692 RGRFSIVKKCIHKATRKDVAVKFVSKK 2718
I+++ K+TR VK +SK+
Sbjct: 21690 -----ILERREKKSTR---WVKVISKR 21708
Score = 63.5 bits (153), Expect = 3e-09
Identities = 49/185 (26%), Positives = 78/185 (42%), Gaps = 18/185 (9%)
Query: 2499 KPTITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
K T+ W P ++ + + S + + + ++ + L+ + I+
Sbjct: 22659 KCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVR 22718
Query: 2550 ATNDHGTTSTSATVKVQG-----VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
A N +G + + +P+ P P +I++W P S G IS Y
Sbjct: 22719 AVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYL 22778
Query: 2605 VEYREEGSQIWQQSVASTL--DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV-- 2660
V+ RE+ S W + + DT L + L GC YQFRV+A N G S PSE S F+
Sbjct: 22779 VDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISC 22838
Query: 2661 RLPEY 2665
R P Y
Sbjct: 22839 REPSY 22843
Score = 62.8 bits (151), Expect = 5e-09
Identities = 51/181 (28%), Positives = 79/181 (43%), Gaps = 15/181 (8%)
Query: 2499 KPTITWKGPDQN--------ILDT-DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
K T+TW P ++ IL+ + S +TV S D L+ + I+
Sbjct: 13991 KATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVS 14050
Query: 2550 ATNDHGTTSTSATVKVQ-----GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
A N +G + V+ G P P +P + + + W P G I+GY
Sbjct: 14051 AVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYH 14110
Query: 2605 VEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLP 2663
VE RE+ S W +++ + + D + L G Y+FRVSA N GI PSE S+ V +
Sbjct: 14111 VERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMK 14170
Query: 2664 E 2664
+
Sbjct: 14171 D 14171
Score = 62.4 bits (150), Expect = 7e-09
Identities = 62/234 (26%), Positives = 94/234 (40%), Gaps = 25/234 (10%)
Query: 2426 RKPKDILGN--KVSVKETNSSEESECDDLDPNT-SMEILNPNFIQEVAPEFLVPLVDVTC 2482
R P I GN + +K N E E +L + + +IL+P ++ +DVTC
Sbjct: 11368 RVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVE----------LDVTC 11417
Query: 2483 L------LGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKIC 2536
+G T+ + +V GRP+P ITW + ++ D + L+I
Sbjct: 11418 RDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQ-----DLPRVELQIK 11472
Query: 2537 NLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTG 2596
+ D G Y A N G SA V V P + + + W P G
Sbjct: 11473 EAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVTKENCTISWENPLDNG 11532
Query: 2597 NCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI 2650
I+ + VEYR+ + W VAS + L+ +L Y FRV A N G+
Sbjct: 11533 GSEITNFIVEYRKPNQKGW-SIVASDVTKRLIKANLLANNEYYFRVCAENKVGV 11585
Score = 62.4 bits (150), Expect = 7e-09
Identities = 51/200 (25%), Positives = 81/200 (40%), Gaps = 25/200 (12%)
Query: 2502 ITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATN 2552
++W P+ N I + S + + T K+ NL+ + A N
Sbjct: 21179 LSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAEN 21238
Query: 2553 DHGTT----STSATVKVQ-GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEY 2607
+G + S+ K Q +P P +P+ + + L W P G ++G+ VE
Sbjct: 21239 RYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEK 21298
Query: 2608 REEGSQIWQQSVASTLD-TYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV------ 2660
+E S +WQ+ S + L G YQFRV A N G+S PS+PS+F
Sbjct: 21299 KERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPV 21358
Query: 2661 ---RLPEY-DAAADGATISW 2676
P+Y D + T+ W
Sbjct: 21359 DPPGTPDYIDVTRETITLKW 21378
Score = 62.4 bits (150), Expect = 7e-09
Identities = 38/111 (34%), Positives = 56/111 (50%), Gaps = 6/111 (5%)
Query: 2470 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG 2529
AP + DVT LG+ L C++ GRP P I W + ++ S Y +SS D
Sbjct: 24035 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ----SRKYKMSS-DGR 24089
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPA-APNRPIAQE 2579
TL + +D G+YTCIATN+ G TS+ + +Q P P P+ ++
Sbjct: 24090 THTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEK 24140
Score = 62.0 bits (149), Expect = 8e-09
Identities = 45/150 (30%), Positives = 67/150 (44%), Gaps = 6/150 (4%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTS---TSATVKVQG--VP 2569
D S+ T+ + S T+K C L + A N +G ++ + TV VP
Sbjct: 15785 DTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVP 15844
Query: 2570 AAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLV 2628
P P+ S S+ ++W P S G + GY +E +E S +W + + + T
Sbjct: 15845 GPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFK 15904
Query: 2629 IEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
L G Y+FRVSA N GI PS+ SE
Sbjct: 15905 TTGLEEGVEYEFRVSAENIVGIGKPSKVSE 15934
Score = 61.6 bits (148), Expect = 1e-08
Identities = 36/104 (34%), Positives = 51/104 (49%), Gaps = 3/104 (2%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLV 2628
PA P R + S +S +L WL P G I+GY +E R++GS W ++ T
Sbjct: 22049 PAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEA-GHTKQLTFT 22107
Query: 2629 IEDLSPGCPYQFRVSASNPWGISLPSE--PSEFVRLPEYDAAAD 2670
+E L Y+FRV A N G S P E S ++ P+ + AD
Sbjct: 22108 VERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTAD 22151
Score = 61.2 bits (147), Expect = 1e-08
Identities = 42/143 (29%), Positives = 64/143 (44%), Gaps = 7/143 (4%)
Query: 2520 TYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ------GVPAAPN 2573
T++ + + + + + NL+P + + A N++G + K P P
Sbjct: 12247 TWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPR 12306
Query: 2574 RPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLVIEDL 2632
+ E + S L WLPP G I GY YREE + + S + D LV+ L
Sbjct: 12307 KLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGL 12366
Query: 2633 SPGCPYQFRVSASNPWGISLPSE 2655
G Y+FRV+A N G+SLP E
Sbjct: 12367 KEGKKYKFRVAARNAVGVSLPRE 12389
Score = 61.2 bits (147), Expect = 1e-08
Identities = 47/189 (24%), Positives = 82/189 (43%), Gaps = 9/189 (4%)
Query: 2520 TYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPI 2576
+Y+ ++ + T K+ L + +A N++G T T+ VK P+ P+
Sbjct: 14416 SYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLN 14475
Query: 2577 AQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGC 2636
+ + ++V L W P G I+GY +E + +GS W + + V+ +L+ G
Sbjct: 14476 IMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTH-ITTVKGLECVVRNLTEGE 14534
Query: 2637 PYQFRVSASNPWGISLPSEP-----SEFVRLPEYDAAADGATISWKENFDSAYTELNEIG 2691
Y F+V A N G S P E E LPE D + + D+ E+ +G
Sbjct: 14535 EYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLG 14594
Query: 2692 RGRFSIVKK 2700
R + ++ K
Sbjct: 14595 RPKPTVTWK 14603
Score = 61.2 bits (147), Expect = 1e-08
Identities = 41/135 (30%), Positives = 60/135 (44%), Gaps = 6/135 (4%)
Query: 2533 LKICNLMPQDSGIYTCIATNDHGT-----TSTSATVKVQGVPAAPNRPIAQERSCTSVIL 2587
LK+ L+ + I+ +A N +G + V G P P P + S+++
Sbjct: 15117 LKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVV 15176
Query: 2588 RWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASN 2646
W P S G I Y VE R++ Q W + TL D + L+ G Y+FR+ A N
Sbjct: 15177 CWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAEN 15236
Query: 2647 PWGISLPSEPSEFVR 2661
GIS PS S F +
Sbjct: 15237 AAGISAPSPTSPFYK 15251
Score = 60.8 bits (146), Expect = 2e-08
Identities = 53/183 (28%), Positives = 76/183 (41%), Gaps = 19/183 (10%)
Query: 2490 LQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG------------EITLKICN 2537
L+ K + T+TW P +LD + Y V +S + + K+
Sbjct: 15461 LKVKEVTKTSVTLTWDPP---LLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQ 15517
Query: 2538 LMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSS 2594
L S + +A N++G T+ +VK P P + + + SV L W P
Sbjct: 15518 LQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKPEH 15577
Query: 2595 TGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPS 2654
G I GY VE + +GS W + A+ T I L G Y FRVSA N GIS P
Sbjct: 15578 DGGSRILGYIVEMQTKGSDKW-ATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPR 15636
Query: 2655 EPS 2657
+ S
Sbjct: 15637 QLS 15639
Score = 60.1 bits (144), Expect = 3e-08
Identities = 47/176 (26%), Positives = 76/176 (43%), Gaps = 15/176 (8%)
Query: 2499 KPTITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
K T+ WK P Q+ + + S +TV + ++ K+ L+ + + +
Sbjct: 16156 KCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRIM 16215
Query: 2550 ATNDHGTTSTSATVKVQG-----VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYT 2604
A N +G + V VP AP P + S+I+ W P+S G I GY
Sbjct: 16216 AVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYV 16275
Query: 2605 VEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEF 2659
+E R++ W + + + L + L Y+FRVSA N G+S PS PS +
Sbjct: 16276 LEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAY 16331
Score = 60.1 bits (144), Expect = 3e-08
Identities = 44/150 (29%), Positives = 68/150 (45%), Gaps = 6/150 (4%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTST--SATVKVQ---GVP 2569
D ++ T+ + S T+KI L + A N +G ++ S V VQ P
Sbjct: 17949 DTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEP 18008
Query: 2570 AAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLV 2628
P P S ++++W P + G I GY +E +E+ S +W + + + DT
Sbjct: 18009 GPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFK 18068
Query: 2629 IEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
L G Y+F+VSA N GI PS+ SE
Sbjct: 18069 TTGLDEGLEYEFKVSAENIVGIGKPSKVSE 18098
Score = 59.7 bits (143), Expect = 4e-08
Identities = 42/145 (28%), Positives = 68/145 (46%), Gaps = 6/145 (4%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAA 2571
+ + Y + + + T +I NL S + +A+N++G T+ VKV P
Sbjct: 18742 ETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLP 18801
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P R + + + ++W P S G I+GY VE + +GS+ W + TL+ I
Sbjct: 18802 PGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEA--TIS 18859
Query: 2631 DLSPGCPYQFRVSASNPWGISLPSE 2655
L+ G Y FRV+A N G S P +
Sbjct: 18860 GLTAGEEYVFRVAAVNEKGRSDPRQ 18884
Score = 59.3 bits (142), Expect = 6e-08
Identities = 37/113 (32%), Positives = 51/113 (45%), Gaps = 5/113 (4%)
Query: 2558 STSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ 2617
ST ATV P P ++R+ S+ L W PP + G I GY VE GS W
Sbjct: 7085 STPATV-----PDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVA 7139
Query: 2618 SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAAD 2670
+T + + L G Y +RV A N G S PS P+E ++ + A +
Sbjct: 7140 CGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPE 7192
Score = 58.2 bits (139), Expect = 1e-07
Identities = 49/177 (27%), Positives = 65/177 (36%), Gaps = 22/177 (12%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTC------------ 2548
T+TW PD D + Y V D CN MP Y
Sbjct: 7403 TLTWCEPDD---DGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFR 7459
Query: 2549 -IATNDHGTTSTSATVKVQGV------PAAPNRPIAQERSCTSVILRWLPPSSTGNCTIS 2601
+A N G S + + + P P +P ++ TSV L W P G I
Sbjct: 7460 VLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIE 7519
Query: 2602 GYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
Y +E + G+ W + T ++ L G Y FRV A N G S PSEPS+
Sbjct: 7520 SYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSD 7576
Score = 58.2 bits (139), Expect = 1e-07
Identities = 33/92 (35%), Positives = 48/92 (52%), Gaps = 1/92 (1%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTY- 2626
VP AP P + SV L W P TG I+GY +E++E S +W+++ + +
Sbjct: 13678 VPDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRD 13737
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
+ L+ G Y+FRV A N G+ PS PSE
Sbjct: 13738 FKVTGLTEGLEYEFRVMAINLAGVGKPSLPSE 13769
Score = 58.2 bits (139), Expect = 1e-07
Identities = 42/173 (24%), Positives = 75/173 (43%), Gaps = 15/173 (8%)
Query: 2501 TITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIAT 2551
TI+W P+ + + + +S T+ + S ++KI L + A
Sbjct: 19008 TISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAE 19067
Query: 2552 NDHGTTSTSATVKVQGV-----PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVE 2606
N +G +S S + V P P P + +++++ W P + G + GY +E
Sbjct: 19068 NRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLE 19127
Query: 2607 YREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
Y+E S +W ++ + DT + + L G Y++RV A N GI S+ E
Sbjct: 19128 YKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCE 19180
Score = 57.8 bits (138), Expect = 2e-07
Identities = 50/205 (24%), Positives = 83/205 (40%), Gaps = 37/205 (18%)
Query: 2490 LQCKVCGRPKP---------------TITWKGPDQN---------ILDTDNSSATYTVSS 2525
++ V GRP P T++W P + I + + T+ S
Sbjct: 9712 MRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVS 9771
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGT-----TSTSATVKVQGVPAAPNRPIAQER 2580
+ E T I L+ ++ +A N +G + + VP AP++P
Sbjct: 9772 SEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSV 9831
Query: 2581 SCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-----SVASTLDTYLVIEDLSPG 2635
+ S+ + W P G ++GY +E ++ S+ W++ A TL + L G
Sbjct: 9832 TRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEG 9891
Query: 2636 CPYQFRVSASNPWGI---SLPSEPS 2657
YQFRV A N G+ SLPS+P+
Sbjct: 9892 SDYQFRVYAINAAGVGPASLPSDPA 9916
Score = 57.8 bits (138), Expect = 2e-07
Identities = 51/178 (28%), Positives = 78/178 (43%), Gaps = 17/178 (9%)
Query: 2490 LQCKVCGRPKPTITWKGP---------DQNILDTDNSSATYTVSSCDSGEITLKICNLMP 2540
LQ K R T+ W P + I D + T++V S + K+ +L
Sbjct: 20875 LQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSE 20934
Query: 2541 QDSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQERSC-TSVILRWLPPSSTG 2596
+ + +A N+ G T+ VK VPA P R ++ + S TSVIL W P G
Sbjct: 20935 KTPFFFRVLAENEIGIGEPCETTEPVKAAEVPA-PIRDLSMKDSTKTSVILSWTKPDFDG 20993
Query: 2597 NCTISGYTVEYREEGSQIWQQS-VASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP 2653
I+ Y VE + +G Q W + ++ T + + + L +FRV A N G+S P
Sbjct: 20994 GSVITEYVVERKGKGEQTWSHAGISKTCE--IEVSQLKEQSVLEFRVFAKNEKGLSDP 21049
Score = 57.4 bits (137), Expect = 2e-07
Identities = 69/297 (23%), Positives = 112/297 (37%), Gaps = 36/297 (12%)
Query: 2390 AESSDGSIKKSCSWHTL-----RMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSS 2444
++SSD I K L MRK V+ T P + + + S +T+
Sbjct: 19672 SDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLR 19731
Query: 2445 EESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKP---- 2500
+ D D TS+ I N N + + ++ + + +V T+++ KV P P
Sbjct: 19732 TRAYVDTTDSRTSLTIENAN--RNDSGKYTLTIQNVLSAASLTLVV--KVLDTPGPPTNI 19787
Query: 2501 ----------TITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQ 2541
++W P+ + I + S + + + ++ K+ NL
Sbjct: 19788 TVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNLQEG 19847
Query: 2542 DSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNC 2598
+ N+ G T VK+ P+ P + S SV L WL P G
Sbjct: 19848 AIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGS 19907
Query: 2599 TISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
I Y VE E+G + W + + T+ V+ L Y FRV A N G+S P E
Sbjct: 19908 RIVHYVVEALEKGQKNWVKCAVAK-STHHVVSGLRENSEYFFRVFAENQAGLSDPRE 19963
Score = 57.0 bits (136), Expect = 3e-07
Identities = 34/93 (36%), Positives = 47/93 (50%), Gaps = 3/93 (3%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ---SVASTLDT 2625
P+ P P A + +C SV L W PP G I GY VEY++ G + W++ + S +T
Sbjct: 10616 PSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPET 10675
Query: 2626 YLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
+ L G Y+FRV A N G S P+ E
Sbjct: 10676 KYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPE 10708
Score = 57.0 bits (136), Expect = 3e-07
Identities = 46/183 (25%), Positives = 78/183 (42%), Gaps = 23/183 (12%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVSSCDSG------------EITLKICNLMPQDSGIYTC 2548
+++W P + D ++ Y V CD + + ++ L+P I+
Sbjct: 12513 SLSWHIP---LEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRV 12569
Query: 2549 IATNDHGTTSTSATVKVQ-----GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
A N G + + K+ GVP+ P + + + + W P S G I GY
Sbjct: 12570 RAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGY 12629
Query: 2604 TVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV-- 2660
+E +E S +W ++ + + T L G Y FR+ A N G S PS+P+E+V
Sbjct: 12630 LIERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTA 12689
Query: 2661 RLP 2663
R+P
Sbjct: 12690 RMP 12692
Score = 56.6 bits (135), Expect = 4e-07
Identities = 42/142 (29%), Positives = 61/142 (42%), Gaps = 4/142 (2%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAA 2571
+++ Y S + + K+ NL + +A N+ G T VK P+
Sbjct: 17659 ESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSP 17718
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIED 2631
P + + S TS L W P G + GY VE + +G++ W VA + V+
Sbjct: 17719 PGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKW-SIVAESKVCNAVVTG 17777
Query: 2632 LSPGCPYQFRVSASNPWGISLP 2653
LS G YQFRV A N G S P
Sbjct: 17778 LSSGQEYQFRVKAYNEKGKSDP 17799
Score = 56.6 bits (135), Expect = 4e-07
Identities = 43/151 (28%), Positives = 60/151 (39%), Gaps = 7/151 (4%)
Query: 2535 ICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ------GVPAAPNRPIAQERSCTSVILR 2588
+ L+P + IA ND G + TS + P+ P S SV L+
Sbjct: 23894 VTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQ 23953
Query: 2589 WLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNP 2647
W P G I GY VEYR+ G W++S + D I L Y+FRV A N
Sbjct: 23954 WEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENE 24013
Query: 2648 WGISLPSEPSEFVRLPEYDAAADGATISWKE 2678
G+S P + ++ A G K+
Sbjct: 24014 TGLSRPRRTAMSIKTKLTSGEAPGIRKEMKD 24044
Score = 56.6 bits (135), Expect = 4e-07
Identities = 48/177 (27%), Positives = 71/177 (40%), Gaps = 23/177 (12%)
Query: 2502 ITWKGPDQNILDTDNSSATYTVSSCDSGE-------------ITLKICNLMPQDSGIYTC 2548
I+WK P D + Y V C++ E T +I NL +
Sbjct: 24245 ISWKPPAD---DGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRV 24301
Query: 2549 IATNDHGTTS---TSATVKVQGV---PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISG 2602
A N G + S+ V ++ P AP +P + S ++ W PP+S G I
Sbjct: 24302 SAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRN 24361
Query: 2603 YTVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
Y +E RE+ W + +T +++L G Y+FRV N G S SE SE
Sbjct: 24362 YYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISE 24418
Score = 56.2 bits (134), Expect = 5e-07
Identities = 50/186 (26%), Positives = 75/186 (40%), Gaps = 20/186 (10%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDS------------GEIT 2532
G V + K + +TW+ P I+D + Y V D+ + +
Sbjct: 13291 GPPVNVTVKEISKDSAYVTWEPP---IIDGGSPIINYVVQKRDAERKSWSTVTTECSKTS 13347
Query: 2533 LKICNLMPQDSGIYTCIATNDHGTTSTSAT---VKVQGVPAAPNRPIAQERSCTSVILRW 2589
++ NL S + A N++G T VK P + S +S + W
Sbjct: 13348 FRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGW 13407
Query: 2590 LPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG 2649
P S G I GY V++ E ++ WQ+ V +L +DL+ G Y FRVSA N G
Sbjct: 13408 KKPHSDGGSRIIGYVVDFLTEENK-WQR-VMKSLSLQYSAKDLTEGKEYTFRVSAENENG 13465
Query: 2650 ISLPSE 2655
PSE
Sbjct: 13466 EGTPSE 13471
Score = 55.8 bits (133), Expect = 6e-07
Identities = 46/175 (26%), Positives = 74/175 (42%), Gaps = 14/175 (8%)
Query: 2501 TITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIAT 2551
TI+W+ P + + D T+ V S S + LKI +L ++ A
Sbjct: 11125 TISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAE 11184
Query: 2552 NDHGT----TSTSATVKVQ-GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVE 2606
N G ST K + P+ P +P+ + + + + W P S G I+GY +E
Sbjct: 11185 NKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYME 11244
Query: 2607 YREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVR 2661
RE + + + D + L G Y+FRV A N G+S PS S+ ++
Sbjct: 11245 RREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIK 11299
Score = 55.5 bits (132), Expect = 8e-07
Identities = 53/246 (21%), Positives = 98/246 (39%), Gaps = 22/246 (8%)
Query: 2389 AAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESE 2448
+A + G++ SC + +++ + E E T E + + + V + +T+ +EE
Sbjct: 970 SAVNEAGTVSTSC-YLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQA 1028
Query: 2449 CDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPD 2508
P + AP F+ V + G +V+ C+V G PKP + WK
Sbjct: 1029 -------------GPG--EPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSG 1073
Query: 2509 QNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG- 2567
+ +Y + +GE L I D+G YT + N HG TS SA++ +
Sbjct: 1074 VPLTTGYRYKVSY---NKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEAD 1130
Query: 2568 --VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDT 2625
+ + + + T+ + + S Y EY +E + I ++ T+
Sbjct: 1131 YELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVV 1190
Query: 2626 YLVIED 2631
+ED
Sbjct: 1191 RTYVED 1196
Score = 53.9 bits (128), Expect = 2e-06
Identities = 31/90 (34%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIW-QQSVASTLDTYL 2627
P+AP RP S ++ +RW P G I GY VE +E + +W +++ L+
Sbjct: 22344 PSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNY 22403
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSEPS 2657
+ L G YQFR A N G+S SE S
Sbjct: 22404 KVTGLVEGLEYQFRTYALNAAGVSKASEAS 22433
Score = 53.5 bits (127), Expect = 3e-06
Identities = 31/92 (33%), Positives = 50/92 (54%), Gaps = 7/92 (7%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-----SVASTL 2623
P P+ P ++++ +S+ L W PP+ G I GY VE +EEG+ W++ + +T
Sbjct: 9208 PGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTC 9267
Query: 2624 DTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
+ V+ +L Y+FRV A N G S PS+
Sbjct: 9268 E--CVVPNLKELRKYRFRVKAVNEAGESEPSD 9297
Score = 53.5 bits (127), Expect = 3e-06
Identities = 34/92 (36%), Positives = 42/92 (45%), Gaps = 1/92 (1%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTY 2626
VP P P + S+ + W P S G I GY VE +E +WQ S A
Sbjct: 14761 VPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNI 14820
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
L+ G Y+FRV A N G S PS+PSE
Sbjct: 14821 FKSSGLTDGIAYEFRVIAENMAGKSKPSKPSE 14852
Score = 53.5 bits (127), Expect = 3e-06
Identities = 42/152 (27%), Positives = 65/152 (42%), Gaps = 14/152 (9%)
Query: 2533 LKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG------VPAAPNRPIAQERSCTSVI 2586
LK+ +LM + A N G + S P P+ P + + S+
Sbjct: 22803 LKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSIS 22862
Query: 2587 LRWLPPSSTGNCTISGYTVEYREEGSQIWQQ--SVASTLDTYLVIEDLSPGCPYQFRVSA 2644
L W P G I GY +E +E+ + W + + A+ +T + DL G Y FRV+A
Sbjct: 22863 LAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAA 22922
Query: 2645 SNPWGISLPS------EPSEFVRLPEYDAAAD 2670
N G+S S EP E + +P+ + A D
Sbjct: 22923 VNVKGMSEYSESIAEIEPVERIEIPDLELADD 22954
Score = 53.1 bits (126), Expect = 4e-06
Identities = 31/96 (32%), Positives = 47/96 (48%), Gaps = 5/96 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P+ L L VT G + GRP+P I+W +Q + S+ D E
Sbjct: 3193 PQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLL-----STGFKCKFLHDGQE 3247
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
TL + P+D+ +YTC A ND+G +TSA++ V+
Sbjct: 3248 YTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVE 3283
Score = 53.1 bits (126), Expect = 4e-06
Identities = 30/71 (42%), Positives = 38/71 (53%), Gaps = 1/71 (1%)
Query: 2583 TSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRV 2642
T V L W P G I+GY VEY+EEG+Q W + T + V+ L G Y+FRV
Sbjct: 10927 TEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVT-NLECVVTGLQQGKTYRFRV 10985
Query: 2643 SASNPWGISLP 2653
A N G+ LP
Sbjct: 10986 KAENIVGLGLP 10996
Score = 52.8 bits (125), Expect = 5e-06
Identities = 33/94 (35%), Positives = 49/94 (52%), Gaps = 5/94 (5%)
Query: 2567 GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTY 2626
G P AP++PI ++ + S++++W P G+ I GY +E RE S W + S L+
Sbjct: 8404 GPPDAPDKPIVEDVTSNSMLVKWNEPKDNGS-PILGYWLEKREVNSTHWSRVNKSLLNAL 8462
Query: 2627 LV-IEDLSPGCPYQFRVSASN---PWGISLPSEP 2656
++ L G Y FRV A N P S PS+P
Sbjct: 8463 KANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDP 8496
Score = 52.8 bits (125), Expect = 5e-06
Identities = 48/187 (25%), Positives = 79/187 (42%), Gaps = 15/187 (8%)
Query: 2490 LQCKVCGRPKPTITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMP 2540
++ K K T+ W+ P + + + S +++ S E + ++
Sbjct: 20476 IEFKTVTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLEECIITTTKIIK 20535
Query: 2541 QDSGIYTCIATNDHGT----TSTSATVKVQGV-PAAPNRPIAQERSCTSVILRWLPPSST 2595
+ I+ A N +G S S K V P P P + + S+ + W P +
Sbjct: 20536 GNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIAD 20595
Query: 2596 GNCTISGYTVEYREEGSQIWQQSVASTL-DTYLVIEDLSPGCPYQFRVSASNPWGISLPS 2654
G ISGY +E R++ S W + + T+ DT + L+ YQ+RV A N G S
Sbjct: 20596 GGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFS 20655
Query: 2655 EPSEFVR 2661
EPSEF +
Sbjct: 20656 EPSEFYK 20662
Score = 52.8 bits (125), Expect = 5e-06
Identities = 56/202 (27%), Positives = 79/202 (39%), Gaps = 33/202 (16%)
Query: 2468 EVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCD 2527
E PEF +PL + T +G+ V + P+P +TW Q I DN YT S D
Sbjct: 25190 ERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDK-KYTFES-D 25247
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPN---RPIAQ------ 2578
G L I ++ D YT +A N +G S A + V P + RP+ +
Sbjct: 25248 KGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANA 25307
Query: 2579 -----ERSCTSVILRWLPP-----SSTGNCTISGYTVEYREEGSQIWQQSVASTLDTY-L 2627
+ C + + +PP G G +E EG LD Y L
Sbjct: 25308 ECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEG-----------LDYYAL 25356
Query: 2628 VIEDLSPGCPYQFRVSASNPWG 2649
I D P +RV+A+N G
Sbjct: 25357 HIRDTLPEDTGYYRVTATNTAG 25378
Score = 52.4 bits (124), Expect = 7e-06
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 1/90 (1%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTYL 2627
P P+ P + S + + W PP G +I+GY +E +E+ S W S + + +
Sbjct: 11899 PGRPDPPEVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPERRM 11958
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSEPS 2657
+++L P YQFRV A N GI PS PS
Sbjct: 11959 KVQNLLPDHEYQFRVKAENEIGIGEPSLPS 11988
Score = 51.6 bits (122), Expect = 1e-05
Identities = 45/172 (26%), Positives = 78/172 (45%), Gaps = 17/172 (9%)
Query: 2501 TITWKGPDQN---------ILDTDNSSATY-TVSSCDSGEITLKICNLMPQDSGIYTCIA 2550
++TW+ P+ + I D +S + T + + +++ + +++ + A
Sbjct: 6711 SLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRA 6770
Query: 2551 TNDHGTTSTSAT---VKVQGVPAAPNRPI---AQERSCTSVILRWLPPSSTGNCTISGYT 2604
N G SA VKV P+ P+ + +++ +SV L+W PP G I GY
Sbjct: 6771 QNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYI 6830
Query: 2605 VEYREEGSQIW-QQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSE 2655
+E EEG W + ++ + + L G Y +RVSA N G+S PSE
Sbjct: 6831 IERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSE 6882
Score = 51.6 bits (122), Expect = 1e-05
Identities = 32/104 (30%), Positives = 48/104 (46%), Gaps = 3/104 (2%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL--DTY 2626
P P+ P + + S L W P G I+GY VE+++ G + W + T T
Sbjct: 14176 PGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQ 14235
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAAD 2670
V+ DL Y FR+SA N G+ P+ + V + E + A D
Sbjct: 14236 FVVPDLQTKEKYNFRISAINDAGVGEPAVIPD-VEIVEREMAPD 14278
Score = 51.6 bits (122), Expect = 1e-05
Identities = 30/91 (32%), Positives = 48/91 (52%), Gaps = 2/91 (2%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIW-QQSVASTLDTYLVIE 2630
P +P+ + +V L+W P TG I+ Y VE R+ + W + + ++ L+ +
Sbjct: 14863 PGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVS 14922
Query: 2631 DLSPGCPYQFRVSASNPWG-ISLPSEPSEFV 2660
L+ Y+FRV A N G IS PSEPS+ +
Sbjct: 14923 GLTEDAAYEFRVIAKNAAGAISPPSEPSDAI 14953
Score = 50.8 bits (120), Expect = 2e-05
Identities = 45/178 (25%), Positives = 77/178 (43%), Gaps = 15/178 (8%)
Query: 2499 KPTITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
K ++TW P Q+ + + S +TV + + +LK+ L+ + ++ +
Sbjct: 17238 KCSLTWSPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIM 17297
Query: 2550 ATNDHGTTST--SATVKVQGVPAAPNRPIAQERSCT---SVILRWLPPSSTGNCTISGYT 2604
A N +G SA V ++ P P + E + S+ + W P S G I GY
Sbjct: 17298 AVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYI 17357
Query: 2605 VEYREEGSQIW-QQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVR 2661
VE R+ W + + D L + L+ Y+FRVSA N G+ PS + + +
Sbjct: 17358 VEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYK 17415
Score = 50.4 bits (119), Expect = 3e-05
Identities = 56/219 (25%), Positives = 87/219 (39%), Gaps = 31/219 (14%)
Query: 2454 PNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILD 2513
P ++E+ F EV+ + PL D G + I+ V R TW +L
Sbjct: 6595 PVRNLEVTE-TFDGEVSLAWEEPLTD-----GGSKIIGYVVERRDIKRKTW------VLA 6642
Query: 2514 TDNS-SATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQG-- 2567
TD + S +TV+ G + ++ A N GT T V+ +
Sbjct: 6643 TDRAESCEFTVTGLQKGGVEY-----------LFRVSARNRVGTGEPVETDNPVEARSKY 6691
Query: 2568 -VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSV-ASTLDT 2625
VP P + + V L W PP G I+ Y +E R++ S W ++ D
Sbjct: 6692 DVPGPPLNVTITDVNRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDL 6751
Query: 2626 YLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
+ D+ G Y FRV A N G+ PS + FV++ +
Sbjct: 6752 SATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVAD 6790
Score = 50.4 bits (119), Expect = 3e-05
Identities = 47/168 (27%), Positives = 68/168 (40%), Gaps = 19/168 (11%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVSSCDSGEITL------------KICNLMPQDSGIYTC 2548
+ITW+ P +LD + Y V ++ + KI L S +
Sbjct: 16554 SITWEPP---LLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRV 16610
Query: 2549 IATNDHGT---TSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTV 2605
A N++G T+ +KV VP P + + + SV L W P G I Y V
Sbjct: 16611 TAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIV 16670
Query: 2606 EYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP 2653
E + + S+ W + A VI +L+ G Y FRV A N G S P
Sbjct: 16671 EMQAKHSEKWSE-CARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDP 16717
Score = 50.1 bits (118), Expect = 3e-05
Identities = 33/98 (33%), Positives = 45/98 (45%), Gaps = 4/98 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F++ V CL G T KV GRP P W Q I+ + T+ V + G
Sbjct: 1411 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIV----NDYTHKVVIKEDGT 1466
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGV 2568
+L I P DSG +T +A N G +S S + V+ V
Sbjct: 1467 QSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAV 1504
Score = 49.7 bits (117), Expect = 4e-05
Identities = 33/88 (37%), Positives = 45/88 (51%), Gaps = 3/88 (3%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P RP A + SV L+W P+ G I+GY VE +E W + S + +DT+ +
Sbjct: 15945 PGRPEAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVT 16004
Query: 2631 DLSPGCPYQFRVSASNPWGISLPSEPSE 2658
L Y+FRV A N G+ SEPSE
Sbjct: 16005 GLVEDHRYEFRVIARNAAGVF--SEPSE 16030
Score = 49.7 bits (117), Expect = 4e-05
Identities = 51/196 (26%), Positives = 81/196 (41%), Gaps = 21/196 (10%)
Query: 2477 LVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG-----EI 2531
LV V G ++ K R TITW+ P +D Y V ++ +
Sbjct: 23034 LVKVYDTPGPCPSVKVKEVSRDSVTITWEIPT---IDGGAPVNNYIVEKREAAMRAFKTV 23090
Query: 2532 TLKICNLMPQDSGI-------YTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQERS 2581
T K + + SG+ + + N +G TS V V VP P + + +
Sbjct: 23091 TTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVT 23150
Query: 2582 CTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYL--VIEDLSPGCPYQ 2639
++V L W P G ++GY +E + G++ W + V + T L + L+ G Y
Sbjct: 23151 KSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMK-VVTLKPTVLEHTVTSLNEGEQYL 23209
Query: 2640 FRVSASNPWGISLPSE 2655
FR+ A N G+S P E
Sbjct: 23210 FRIRAQNEKGVSEPRE 23225
Score = 49.7 bits (117), Expect = 4e-05
Identities = 46/177 (25%), Positives = 70/177 (39%), Gaps = 23/177 (12%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVSSCDSGE------------ITLKICNLMPQDSGIYTC 2548
TI+W+ P+ LD + Y V D+ T K L + ++
Sbjct: 23353 TISWEPPE---LDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRV 23409
Query: 2549 IATNDHGTTSTSATVKVQ-----GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
ATN G S + ++ +P P + S + L W PP G ++GY
Sbjct: 23410 AATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGY 23469
Query: 2604 TVEYREEGSQIWQQ--SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
VE +E + W + V T+ Y L+ G Y+ RV+A N G PS PS+
Sbjct: 23470 IVERKEVRADRWVRVNKVPVTMTRYR-STGLTEGLEYEHRVTAINARGSGKPSRPSK 23525
Score = 49.3 bits (116), Expect = 6e-05
Identities = 48/203 (23%), Positives = 78/203 (38%), Gaps = 14/203 (6%)
Query: 2472 EFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQN--------ILDTDNSSATYTV 2523
+F V+V + G + L+ V R + W P+ + I++ ++
Sbjct: 8688 KFAAARVEVFDVPGPVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWR 8747
Query: 2524 SSCDSGEITLKICNLMPQDSGIYTCIATNDHGT-----TSTSATVKVQGVPAAPNRPIAQ 2578
++ I L+ + IA N G V G P +P R
Sbjct: 8748 QPIETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYT 8807
Query: 2579 ERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGCP 2637
ER+ +++ L W P S G I GY +E R +++ + T ++E+L
Sbjct: 8808 ERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQM 8867
Query: 2638 YQFRVSASNPWGISLPSEPSEFV 2660
Y+FRV A N G S PS P V
Sbjct: 8868 YEFRVKAVNEIGESEPSLPLNVV 8890
Score = 49.3 bits (116), Expect = 6e-05
Identities = 71/323 (21%), Positives = 121/323 (37%), Gaps = 34/323 (10%)
Query: 2398 KKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTS 2457
KK W ++ + E + KN G L + VK N ESE ++ S
Sbjct: 24369 KKQNKWISVTTEEIRETVFSVKNLIEG-------LEYEFRVKCENLGGESEWSEI----S 24417
Query: 2458 MEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNS 2517
I + + AP F L ++ L CKV G PKP + W + I+
Sbjct: 24418 EPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEII---AD 24474
Query: 2518 SATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA 2577
Y + G L I ++ D+ +Y ATN G+ S +A+++V+ VPA + P
Sbjct: 24475 GLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVE-VPAKIHLPKT 24533
Query: 2578 QERSCTSVILRW------LPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIED 2631
E LR +P S + I+ + + + +Q V + + +
Sbjct: 24534 LEGMGAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNG 24593
Query: 2632 LSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE-------YDAAADGATISWKENFDSAY 2684
+ + V A N +GI + + +P+ D + D ++W E
Sbjct: 24594 VERKDAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGG 24653
Query: 2685 TELNEIGRGRFSIVKKCIHKATR 2707
+++ IV+KC A R
Sbjct: 24654 SKITNY------IVEKCATTAER 24670
Score = 48.9 bits (115), Expect = 7e-05
Identities = 29/95 (30%), Positives = 46/95 (48%), Gaps = 4/95 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P FL L + C G I + V G P PT+TW ++ + +S YT+ +G
Sbjct: 3575 PHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLC----TSVYYTIIHNPNGS 3630
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV 2565
T + + +DSG+Y C A N G ++ +A + V
Sbjct: 3631 GTFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3665
Score = 48.5 bits (114), Expect = 1e-04
Identities = 49/163 (30%), Positives = 73/163 (44%), Gaps = 20/163 (12%)
Query: 2418 GKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPL 2477
G+ + T P K G + S+K TN S ++ + E PNF+Q L
Sbjct: 61 GRAKLTIPAVTKANSG-RYSLKATNGSGQAT-STAELLVKAETAPPNFVQR--------L 110
Query: 2478 VDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEI-TLKIC 2536
+T G V LQ +V G P P + + I SS + +S G++ +L I
Sbjct: 111 QSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEI----QSSLDFQISQ--EGDLYSLLIA 164
Query: 2537 NLMPQDSGIYTCIATNDHGTTSTSATVKVQG---VPAAPNRPI 2576
P+DSG Y+ ATN G +++A + VQG VPA + I
Sbjct: 165 EAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTI 207
Score = 48.5 bits (114), Expect = 1e-04
Identities = 33/99 (33%), Positives = 49/99 (49%), Gaps = 3/99 (3%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P +P + SV L W P G ++GY VE R+ S+ W + + + + +
Sbjct: 13780 PGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVT 13839
Query: 2631 DLSPGCPYQFRVSASNPWG-ISLPSEPSE-FVRLPEYDA 2667
DL G Y+FR+ A N G IS PSE +E + EY+A
Sbjct: 13840 DLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEA 13878
Score = 48.5 bits (114), Expect = 1e-04
Identities = 30/95 (31%), Positives = 44/95 (46%), Gaps = 2/95 (2%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQ--QSVASTLDTY 2626
P P + + + +S+ L W P G ++GY VE R+ + W + T
Sbjct: 20670 PGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTE 20729
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVR 2661
V+ +L PG Y FRVSA N G P E +E V+
Sbjct: 20730 YVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQ 20764
Score = 48.1 bits (113), Expect = 1e-04
Identities = 36/127 (28%), Positives = 46/127 (36%), Gaps = 1/127 (0%)
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRW 2589
+ + +I D G Y + N HG +KV VP E V L W
Sbjct: 6554 QTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLAW 6613
Query: 2590 LPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSP-GCPYQFRVSASNPW 2648
P + G I GY VE R+ + W + + L G Y FRVSA N
Sbjct: 6614 EEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSARNRV 6673
Query: 2649 GISLPSE 2655
G P E
Sbjct: 6674 GTGEPVE 6680
Score = 47.8 bits (112), Expect = 2e-04
Identities = 34/104 (32%), Positives = 47/104 (45%), Gaps = 15/104 (14%)
Query: 2567 GVPAAPNRPIAQERSC-------------TSVILRWLPPSSTGNCTISGYTVEYREEGSQ 2613
G P+ P+ P+ +C SV L W P+ G I+GY VE R+
Sbjct: 20256 GKPSHPSEPVLAIDACEPPRNVRITDISKNSVSLSWQQPAFDGGSKITGYIVERRDLPDG 20315
Query: 2614 IW-QQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG-ISLPSE 2655
W + S + +T +I L+ Y+FRV A N G IS PSE
Sbjct: 20316 RWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSE 20359
Score = 47.8 bits (112), Expect = 2e-04
Identities = 30/99 (30%), Positives = 44/99 (44%), Gaps = 2/99 (2%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVAS--TLDT 2625
VP AP P + S+ L W P S G I Y +E RE+ S W + ++ +T
Sbjct: 21654 VPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISET 21713
Query: 2626 YLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
+ L+ G Y+F V A N G+ S S ++ E
Sbjct: 21714 RFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCRE 21752
Score = 47.8 bits (112), Expect = 2e-04
Identities = 29/105 (27%), Positives = 45/105 (42%), Gaps = 7/105 (6%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYL 2627
P P P + + TSV L W P G ++GY +E ++ W + + T
Sbjct: 23536 PGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREY 23595
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSE------PSEFVRLPEYD 2666
+ L G Y+FRV A N G P+E +E + P+Y+
Sbjct: 23596 TLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYE 23640
Score = 47.4 bits (111), Expect = 2e-04
Identities = 30/90 (33%), Positives = 42/90 (46%), Gaps = 6/90 (6%)
Query: 2483 LLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQD 2542
L G V CK+ G P P I W + I + Y + G +L+I ++P+D
Sbjct: 1257 LEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGER----YQMDFLQDGRASLRIPVVLPED 1312
Query: 2543 SGIYTCIATNDHGTTSTSATVKVQGVPAAP 2572
GIYT A+N G S + V+ PAAP
Sbjct: 1313 EGIYTAFASNIKGNAICSGKLYVE--PAAP 1340
Score = 47.4 bits (111), Expect = 2e-04
Identities = 27/87 (31%), Positives = 40/87 (45%), Gaps = 1/87 (1%)
Query: 2573 NRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIW-QQSVASTLDTYLVIED 2631
N P + + +SV L W P G ++GY +E +E + W + + T +
Sbjct: 23837 NPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTG 23896
Query: 2632 LSPGCPYQFRVSASNPWGISLPSEPSE 2658
L P YQFR+ A N G+S S SE
Sbjct: 23897 LVPDAEYQFRIIAQNDVGLSETSPASE 23923
Score = 46.6 bits (109), Expect = 4e-04
Identities = 80/342 (23%), Positives = 124/342 (36%), Gaps = 60/342 (17%)
Query: 2349 QVLAVNQQNMCLVYQP-----ASDHSPAAEGWVPGSILAPLT-----KATAAESSDGSIK 2398
+V A+N+Q +P A D A E ++ +LA LT K + G +
Sbjct: 7163 RVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPE 7222
Query: 2399 KSCSWHT----LRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEE-SECDDLD 2453
+W L+ KR +EN K I+ +K S T E + C
Sbjct: 7223 PKITWTKADMILKQDKRITIENVPKKSTV------TIVDSKRSDTGTYIIEAVNVC---- 7272
Query: 2454 PNTSMEILNPNFIQEVAPEFLVPLVDVT---CLL--------GDTVILQCKVCGRPKPTI 2502
+ ++ N + + P + DVT CLL G + I V R +
Sbjct: 7273 -GRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSE 7331
Query: 2503 TWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGT----TS 2558
W + DT+ K L+P I+ A N +G +
Sbjct: 7332 VWHKLSSTVKDTN-----------------FKATKLIPNKEYIFRVAAENMYGVGEPVQA 7374
Query: 2559 TSATVKVQ-GVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ 2617
+ T K Q P P R + + +V L W P G I+GY VE + + W +
Sbjct: 7375 SPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVR 7434
Query: 2618 -SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSE 2658
+ DT ++ L+ Y+FRV A N G PS+ +E
Sbjct: 7435 CNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTE 7476
Score = 46.6 bits (109), Expect = 4e-04
Identities = 26/88 (29%), Positives = 40/88 (45%), Gaps = 1/88 (1%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDT-YL 2627
P P P + S T++ L W PP+ G I GY V+ + G+ W + +
Sbjct: 8505 PPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQY 8564
Query: 2628 VIEDLSPGCPYQFRVSASNPWGISLPSE 2655
++++ G Y+ RVSA N G P E
Sbjct: 8565 TVKEIREGADYKLRVSAVNAAGEGPPGE 8592
Score = 46.6 bits (109), Expect = 4e-04
Identities = 36/130 (27%), Positives = 50/130 (38%), Gaps = 8/130 (6%)
Query: 2529 GEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGV------PAAPNRPIAQERSC 2582
GE+ L++ L+ + A N G + S Q P PN P + +
Sbjct: 16295 GELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITR 16354
Query: 2583 TSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVAST--LDTYLVIEDLSPGCPYQF 2640
+SV L W P G C I GY VE + W T T + +E L Y F
Sbjct: 16355 SSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNF 16414
Query: 2641 RVSASNPWGI 2650
R+ A N G+
Sbjct: 16415 RICAINKAGV 16424
Score = 46.6 bits (109), Expect = 4e-04
Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 3/91 (3%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P P + + ++ L+W PP G I GY++E R+ G++ W + + + +
Sbjct: 21361 PGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQ-GNERWVRCNFTDVSECQYTVT 21419
Query: 2631 DLSPGCPYQFRVSASNPWG-ISLPSEPSEFV 2660
LSPG Y+FR+ A N G IS PS+ S +
Sbjct: 21420 GLSPGDRYEFRIIARNAVGTISPPSQSSGII 21450
Score = 46.2 bits (108), Expect = 5e-04
Identities = 32/104 (30%), Positives = 45/104 (43%), Gaps = 3/104 (2%)
Query: 2470 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG 2529
AP F PL V L G T + + G P P ++W Q I S+ S G
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVI---STSTLPGVQISFSDG 61
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPN 2573
L I + +SG Y+ ATN G +++A + V+ A PN
Sbjct: 62 RAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPN 105
Score = 46.2 bits (108), Expect = 5e-04
Identities = 30/95 (31%), Positives = 46/95 (48%), Gaps = 5/95 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F+ + + +GD L V G PKP I W +L T ++ + D +
Sbjct: 3457 PIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFF--NGVLLTPSADYKFVF---DGDD 3511
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV 2565
+L I +D G YTC+A+ND+G T SA +K+
Sbjct: 3512 HSLIILFTKLEDEGEYTCMASNDYGKTICSAYLKI 3546
Score = 46.2 bits (108), Expect = 5e-04
Identities = 30/110 (27%), Positives = 42/110 (38%), Gaps = 8/110 (7%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVAST--LDTY 2626
P P+ P + S +SV L W P G + GY VE +E + W T
Sbjct: 18506 PGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQ 18565
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSE------PSEFVRLPEYDAAAD 2670
+ L Y FR+ A N G+ P+ E + PE + AD
Sbjct: 18566 FTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDAD 18615
Score = 45.4 bits (106), Expect = 8e-04
Identities = 25/81 (30%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 2585 VILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVAST-LDTYLVIEDLSPGCPYQFRVS 2643
V L+W PP + G I Y +E +E W ++ + D + D+ G QF+V
Sbjct: 7703 VDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVR 7762
Query: 2644 ASNPWGISLPSEPSEFVRLPE 2664
A N G+ PSEP+E + + +
Sbjct: 7763 AENEAGVGHPSEPTEILSIED 7783
Score = 45.4 bits (106), Expect = 8e-04
Identities = 54/224 (24%), Positives = 80/224 (35%), Gaps = 60/224 (26%)
Query: 2496 GRPKP-----------TITWKGPDQN--------ILDTDNSSATYTVSSCDSG--EITLK 2534
GRP P T+ W P+ + L+ +T V S E +K
Sbjct: 11900 GRPDPPEVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWVPVNKSAIPERRMK 11959
Query: 2535 ICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQ---------------- 2578
+ NL+P + A N+ G G P+ P+RP+
Sbjct: 11960 VQNLLPDHEYQFRVKAENEIGI----------GEPSLPSRPVVAKDPIEPPGPPTNFRVV 12009
Query: 2579 ERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQI-----WQQ--SVASTLDTYLVIED 2631
+ + S+ L W P G I GY VE R + + W++ + A + +
Sbjct: 12010 DTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTS 12069
Query: 2632 LSPGCPYQFRVSASNPWGISLPSE------PSEFVRLPEYDAAA 2669
L Y+FRV A N GI P+E P E + PE D A
Sbjct: 12070 LDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDA 12113
Score = 45.4 bits (106), Expect = 8e-04
Identities = 46/155 (29%), Positives = 60/155 (38%), Gaps = 14/155 (9%)
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV------QGVPAAPNRPIAQERSCT 2583
E TLK L + A N G S K Q P P P + + +
Sbjct: 13047 ERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRS 13106
Query: 2584 SVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLD-TYLVIEDLSPGCPYQFR 2641
SV L W P+ G I GY VE + S W + ++ L T + L YQFR
Sbjct: 13107 SVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFR 13166
Query: 2642 VSASNPWGISLPSE------PSEFVRLPEYDAAAD 2670
V A N G S PS+ P + + PE + AD
Sbjct: 13167 VYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDAD 13201
Score = 45.4 bits (106), Expect = 8e-04
Identities = 51/277 (18%), Positives = 107/277 (38%), Gaps = 25/277 (9%)
Query: 2304 QPGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQ 2363
+P + E K N + S++ ++ Y+L+ VS + A N + C
Sbjct: 26663 EPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQC---- 26718
Query: 2364 PASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEAT 2423
S A V + P + S D S++ S S +++M + + ++
Sbjct: 26719 -----SATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSS 26773
Query: 2424 GPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQE------------VAP 2471
++ +S + +S +ES + + ++ M I N ++ + P
Sbjct: 26774 SASSMTEMKFASMSAQSMSSMQESFVE-MSSSSFMGISNMTQLESSTSKMLKAGIRGIPP 26832
Query: 2472 EFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEI 2531
+ D++ G + + C G P P +TW + I + + + + D
Sbjct: 26833 KIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGR--FHIENTDD-LT 26889
Query: 2532 TLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGV 2568
TL I ++ QD G+YT N+ G+ S + + ++ +
Sbjct: 26890 TLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIRSI 26926
Score = 45.1 bits (105), Expect = 0.001
Identities = 30/88 (34%), Positives = 42/88 (47%), Gaps = 3/88 (3%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P +P + SV L+W P G I+GY VE RE W + + + +TY +
Sbjct: 19191 PGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVT 19250
Query: 2631 DLSPGCPYQFRVSASNPWGISLPSEPSE 2658
+L+ Y+FRV A N SEPSE
Sbjct: 19251 ELTEDQRYEFRVFARN--AADSVSEPSE 19276
Score = 44.7 bits (104), Expect = 0.001
Identities = 43/174 (24%), Positives = 71/174 (40%), Gaps = 21/174 (12%)
Query: 2502 ITWKGPDQN---------ILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATN 2552
++WK PD + I +T + D G T + +L+ + + A N
Sbjct: 9433 LSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAEN 9492
Query: 2553 DHGTTSTSATVK---VQGVPAAPNRPIAQERSC---TSVILRWLPPSSTGNCTISGYTVE 2606
G T++ + P+ PI + +V L W PP + G ++ Y VE
Sbjct: 9493 RFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVE 9552
Query: 2607 ---YREEGS--QIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPS 2654
+ G+ + W+Q + + +EDL G Y+FRV A N G+S PS
Sbjct: 9553 CLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPS 9606
Score = 44.3 bits (103), Expect = 0.002
Identities = 48/199 (24%), Positives = 76/199 (38%), Gaps = 32/199 (16%)
Query: 2487 TVILQCKVCGRPKPT--------------ITWKGPDQN--------ILDTDNSSA-TYTV 2523
T + KV G P P +TW+ P+ + +L+ + TY
Sbjct: 7972 TASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIP 8031
Query: 2524 SSCDSGEITLKICNLMPQDSGIYTCIATNDHGT---TSTSATVKVQGVPAAPNRPIAQE- 2579
+++ + +L+P + A N G V Q P+ P+ E
Sbjct: 8032 VMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEV 8091
Query: 2580 --RSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLD--TYLVIEDLSPG 2635
+ ++ + W PP G I GY +E +G + W++ + TY + L G
Sbjct: 8092 HNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTY-TAKGLEEG 8150
Query: 2636 CPYQFRVSASNPWGISLPS 2654
YQFRV A N GIS PS
Sbjct: 8151 KEYQFRVRAENAAGISEPS 8169
Score = 44.3 bits (103), Expect = 0.002
Identities = 30/88 (34%), Positives = 43/88 (48%), Gaps = 2/88 (2%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYLVIE 2630
P RP A + +V L+W P+ G I+GY VE ++ W + S + L+T +
Sbjct: 18109 PGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVS 18168
Query: 2631 DLSPGCPYQFRVSASNPWG-ISLPSEPS 2657
L Y+FRV A N G S PS+ S
Sbjct: 18169 GLVEDQRYEFRVIARNAAGNFSEPSDSS 18196
Score = 44.3 bits (103), Expect = 0.002
Identities = 30/109 (27%), Positives = 46/109 (42%), Gaps = 4/109 (3%)
Query: 2546 YTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTV 2605
Y A + S + Q AP RP + + ++V L W P+ G + GY +
Sbjct: 22419 YALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGYII 22478
Query: 2606 EYR---EEGSQIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI 2650
E + E G W + + D + + LS G Y+FRV A N G+
Sbjct: 22479 ERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGV 22527
Score = 43.9 bits (102), Expect = 0.002
Identities = 34/119 (28%), Positives = 50/119 (42%), Gaps = 8/119 (6%)
Query: 2550 ATNDHGTTSTSATVKVQGV--PAAPNRPIAQ----ERSCTSVILRWLPPSSTGNCTISGY 2603
A N+ G S ++ + P +P P + + + W PP G I GY
Sbjct: 7763 AENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGY 7822
Query: 2604 TVEYREEGSQIWQQSVASTLD--TYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
VE G++ W + + + + V E + P Y RV A N G+S PSE SE V
Sbjct: 7823 HVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENV 7881
Score = 43.9 bits (102), Expect = 0.002
Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 4/96 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F L + C G +V + +V G P PT+ W+ Q + N +
Sbjct: 25298 PMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHE----GLDY 25353
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
L I + +P+D+G Y ATN G+TS A ++V+
Sbjct: 25354 YALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVE 25389
Score = 43.5 bits (101), Expect = 0.003
Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 2/94 (2%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL--DTY 2626
P P P +++S + L W P S G I GY VE ++ G+ W + L
Sbjct: 11307 PGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCA 11366
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFV 2660
+ L G Y+FR+ A+N G P E +E V
Sbjct: 11367 FRVPGLIEGNEYRFRIKAANIVGEGEPRELAESV 11400
Score = 43.5 bits (101), Expect = 0.003
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 4/89 (4%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQ-SVASTLDTYL 2627
P PI +R+ + L+W P G I+GY VE R+ W + S + ++T
Sbjct: 17026 PPGTPEPIMVKRN--EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQF 17083
Query: 2628 VIEDLSPGCPYQFRVSASNPWG-ISLPSE 2655
+ L+ Y+FRV A N G IS PS+
Sbjct: 17084 TVSGLTEDQRYEFRVIAKNAAGAISKPSD 17112
Score = 43.5 bits (101), Expect = 0.003
Identities = 27/111 (24%), Positives = 45/111 (40%), Gaps = 5/111 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P + L D T K G P+PT W + I Y +S D G
Sbjct: 26355 PVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAI----TQGGKYKLSE-DKGG 26409
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERS 2581
L+I DSG+YTC N G+ S+S + ++ + + ++ +++
Sbjct: 26410 FFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKT 26460
Score = 43.1 bits (100), Expect = 0.004
Identities = 42/167 (25%), Positives = 63/167 (37%), Gaps = 18/167 (10%)
Query: 2501 TITWKGPD--------QNILDTDNSSATY---TVSSCDSGEITLKICNLMPQDSGIYTCI 2549
T+TW P+ Q IL+ +T +S E K+ L + + +
Sbjct: 21672 TLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVM 21731
Query: 2550 ATNDHGTTSTSATVKV------QGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
A N G S ++ P P + S T+V L W P G I GY
Sbjct: 21732 AENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGY 21791
Query: 2604 TVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVSASNPWG 2649
+E + W + + + + T + DL G Y+FRVSA N G
Sbjct: 21792 IIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAG 21838
Score = 42.7 bits (99), Expect = 0.005
Identities = 23/65 (35%), Positives = 31/65 (47%)
Query: 2587 LRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASN 2646
L+W P G I+ Y VE R+ + WQ + DT + L+ G Y FRV+A N
Sbjct: 7605 LKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAEN 7664
Query: 2647 PWGIS 2651
G S
Sbjct: 7665 AIGQS 7669
Score = 42.0 bits (97), Expect = 0.009
Identities = 31/122 (25%), Positives = 56/122 (45%), Gaps = 7/122 (5%)
Query: 2459 EILNPNFIQEVAPEFLV-PLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNS 2517
E+++P+ V P ++ PL D G QC+V G ++W D+ I
Sbjct: 3286 EVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLK-VSWYSKDKKI----KP 3340
Query: 2518 SATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIA 2577
S + ++ + L+I P+D G YT +A+N G S++A + ++ + + I
Sbjct: 3341 SRFFRMTQFED-TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIE 3399
Query: 2578 QE 2579
QE
Sbjct: 3400 QE 3401
Score = 42.0 bits (97), Expect = 0.009
Identities = 29/97 (29%), Positives = 42/97 (43%), Gaps = 5/97 (5%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G V+ C++ G P P I W + I + N S S +L+I N DSG
Sbjct: 26651 GQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSI-----SRSRNVYSLEIRNASVSDSG 26705
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERS 2581
YT A N G S +A++ V + P+R + S
Sbjct: 26706 KYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTS 26742
Score = 40.4 bits (93), Expect = 0.026
Identities = 41/170 (24%), Positives = 65/170 (38%), Gaps = 23/170 (13%)
Query: 2501 TITWKGPDQNILDTDNSSATYTVS----------SCDSGEITLKI--CNLMPQDSGIYTC 2548
TI+W+ P LD S T + S + ++T ++ NL+ + +
Sbjct: 11522 TISWENP----LDNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRV 11577
Query: 2549 IATNDHGTTSTSAT------VKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISG 2602
A N G T T + P P ++ T V L+W P G
Sbjct: 11578 CAENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLS 11637
Query: 2603 YTVEYREEGSQIWQQ-SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGIS 2651
Y VE R +GS W++ S +T+ +++ Y+FRV N G S
Sbjct: 11638 YHVERRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNEGGES 11687
Score = 40.4 bits (93), Expect = 0.026
Identities = 43/191 (22%), Positives = 74/191 (38%), Gaps = 19/191 (9%)
Query: 2376 VPGSILAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNK 2435
VP S+ LT+ A S S KK+ + + + T E+ + K
Sbjct: 25983 VPRSVFPELTRTEAYAVS--SFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMK 26040
Query: 2436 VSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVC 2495
+ E S EE +T+ +I +A L +T G++ C
Sbjct: 26041 SAALEEKSLEEK-------STTRKIKTT-----LAARILTKPRSMTVYEGESARFSCDTD 26088
Query: 2496 GRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHG 2555
G P PT+TW Q + ++SA + V++ + T +I ++ D G Y+ + N G
Sbjct: 26089 GEPVPTVTWLRKGQVL----STSARHQVTT-TKYKSTFEISSVQASDEGNYSVVVENSEG 26143
Query: 2556 TTSTSATVKVQ 2566
T+ +Q
Sbjct: 26144 KQEAEFTLTIQ 26154
Score = 40.0 bits (92), Expect = 0.035
Identities = 30/105 (28%), Positives = 43/105 (40%), Gaps = 3/105 (2%)
Query: 2468 EVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCD 2527
+V P F+ L +V G + ++ + G P P I W I+ +
Sbjct: 1507 QVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTK-- 1564
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAP 2572
GE LKI + + QDS YT A N G +T V V+ A P
Sbjct: 1565 -GEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEP 1608
Score = 39.3 bits (90), Expect = 0.059
Identities = 27/88 (30%), Positives = 39/88 (44%), Gaps = 1/88 (1%)
Query: 2568 VPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTL-DTY 2626
VP P +E + +V L W PP G I Y +E R G++ + + L
Sbjct: 10219 VPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRK 10278
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGISLPS 2654
++ L G Y++RVSA N G PS
Sbjct: 10279 YTVKGLKEGDTYEYRVSAVNIVGQGKPS 10306
Score = 38.1 bits (87), Expect = 0.13
Identities = 31/110 (28%), Positives = 43/110 (39%), Gaps = 8/110 (7%)
Query: 2569 PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQ--QSVASTLDTY 2626
P P P + S +S+ + W P G I+GY VE WQ A T
Sbjct: 15259 PGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATS 15318
Query: 2627 LVIEDLSPGCPYQFRVSASNPWGIS----LPSEPSEFVRL--PEYDAAAD 2670
I L+ Y+ R+ A N G+ +P P R+ PE + AD
Sbjct: 15319 YTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDAD 15368
Score = 37.7 bits (86), Expect = 0.17
Identities = 26/102 (25%), Positives = 45/102 (44%), Gaps = 9/102 (8%)
Query: 2466 IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSS--ATYTV 2523
++ AP + + LG C++ P W + I ++D S ++ +
Sbjct: 4332 VKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYI 4391
Query: 2524 SSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV 2565
SS L+I D G YTC A+N++G+ S +AT+ V
Sbjct: 4392 SS-------LEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4426
Score = 37.4 bits (85), Expect = 0.22
Identities = 35/132 (26%), Positives = 54/132 (40%), Gaps = 9/132 (6%)
Query: 2435 KVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKV 2494
K S ++ SS ES +++ ++ I+E P PLVD GD V L +
Sbjct: 4208 KPSEEKEESSSESGTEEV-ATVKIQEAEGGLIKEDGPMIHTPLVDTVSEEGDIVHLTTSI 4266
Query: 2495 CGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQD-SGIYTCIATND 2553
+ + W ++ + + D TL I + +D G Y C A ND
Sbjct: 4267 TNAKE--VNWYFENKLVPSDEKFKCLQ-----DQNTYTLVIDKVNTEDHQGEYVCEALND 4319
Query: 2554 HGTTSTSATVKV 2565
G T+TSA + V
Sbjct: 4320 SGKTATSAKLTV 4331
Score = 36.6 bits (83), Expect = 0.38
Identities = 48/191 (25%), Positives = 71/191 (37%), Gaps = 26/191 (13%)
Query: 2501 TITWKGPDQN--------ILDTDNSSATYTVSSCDSGEIT---LKICNLMPQDSGIYTCI 2549
T+ W PD + I++ + S + C+ IT L++ L +
Sbjct: 17339 TVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIK-CNKRRITDLRLRVTGLTEDHEYEFRVS 17397
Query: 2550 ATNDHGTTSTS-ATVKVQGV-----PAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGY 2603
A N G S ATV + P P + + S+ L W P G I GY
Sbjct: 17398 AENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGY 17457
Query: 2604 TVEYREEGSQIWQQSVAST--LDTYLVIEDLSPGCPYQFRVSASNPWGI----SLPS--E 2655
VE + + WQ T T I L+ Y+ RV A N G+ S+P +
Sbjct: 17458 VVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVK 17517
Query: 2656 PSEFVRLPEYD 2666
P + + PE D
Sbjct: 17518 PEDKLEAPELD 17528
Score = 36.2 bits (82), Expect = 0.50
Identities = 47/199 (23%), Positives = 71/199 (35%), Gaps = 20/199 (10%)
Query: 2381 LAPLTKATAAESSDGSIKKSCSWHTLRMR---KRAEVENTGKNEATGPRKPKDILGNKVS 2437
L PL TA E S +R++ + T K I +S
Sbjct: 5435 LTPLKDVTAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLS 5494
Query: 2438 VKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGR 2497
+ +T S E + + +L E P F L D T + D VILQC++
Sbjct: 5495 IDDT-SQIRVEAMGMSSEAKLTVL------EGDPYFTGKLQDYTGVEKDEVILQCEISKA 5547
Query: 2498 PKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTT 2557
P + W + I + N+ V D + L + + D G YTC D GT
Sbjct: 5548 DAP-VKWFKDGKEIKPSKNA-----VIKADGKKRMLILKKALKSDIGQYTC----DCGTD 5597
Query: 2558 STSATVKVQGVPAAPNRPI 2576
TS + ++ RP+
Sbjct: 5598 KTSGKLDIEDREIKLVRPL 5616
Score = 35.8 bits (81), Expect = 0.65
Identities = 24/69 (34%), Positives = 33/69 (47%), Gaps = 3/69 (4%)
Query: 2499 KPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTS 2558
KPT K + ++S YT +S G +TL+I + DSG Y + TN G S
Sbjct: 25903 KPTAEVKWYHNGVELQESSKIHYTNTS---GVLTLEILDCHTDDSGTYRAVCTNYKGEAS 25959
Query: 2559 TSATVKVQG 2567
AT+ V G
Sbjct: 25960 DYATLDVTG 25968
Score = 35.4 bits (80), Expect = 0.85
Identities = 29/96 (30%), Positives = 41/96 (42%), Gaps = 7/96 (7%)
Query: 2572 PNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIED 2631
P +P + + ++V L W P G I GY VE + W + +T + E+
Sbjct: 12696 PGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVR--CNTAPHQIPQEE 12753
Query: 2632 -----LSPGCPYQFRVSASNPWGISLPSEPSEFVRL 2662
L YQFR A IS PSEPS+ V +
Sbjct: 12754 YTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTI 12789
Score = 34.3 bits (77), Expect = 1.9
Identities = 16/26 (61%), Positives = 20/26 (76%)
Query: 2541 QDSGIYTCIATNDHGTTSTSATVKVQ 2566
+DSGI TC ATN +GT TSAT+ V+
Sbjct: 1724 RDSGIITCRATNKYGTDHTSATLIVK 1749
Score = 34.3 bits (77), Expect = 1.9
Identities = 37/147 (25%), Positives = 63/147 (42%), Gaps = 21/147 (14%)
Query: 2434 NKVSVKETN----SSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVI 2489
+K+ +KE S +++ +L +++L E P F V L D T + D +
Sbjct: 5131 HKLEMKEVTLDDISQIKAQVKELSSTAQLKVL------EADPYFTVKLHDKTAVEKDEIT 5184
Query: 2490 LQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCI 2549
L+C+V + P +K ++ + S Y++ + D LKI +D G Y C
Sbjct: 5185 LKCEV-SKDVPVKWFKDGEEIV-----PSPKYSIKA-DGLRRILKIKKADLKDKGEYVC- 5236
Query: 2550 ATNDHGTTSTSATVKVQGVPAAPNRPI 2576
D GT T A V V+ +P+
Sbjct: 5237 ---DCGTDKTKANVTVEARLIKVEKPL 5260
Score = 33.5 bits (75), Expect = 3.2
Identities = 23/85 (27%), Positives = 39/85 (45%), Gaps = 6/85 (7%)
Query: 2485 GDTVILQCKVCGRPKPT-ITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDS 2543
G V CK+ + T +TW + + +++ TY + G L + ++ D
Sbjct: 25085 GGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITY-----EDGVAILYVKDITKLDD 25139
Query: 2544 GIYTCIATNDHGTTSTSATVKVQGV 2568
G Y C ND+G S+ A + V+GV
Sbjct: 25140 GTYRCKVVNDYGEDSSYAELFVKGV 25164
Score = 32.3 bits (72), Expect = 7.2
Identities = 34/154 (22%), Positives = 61/154 (39%), Gaps = 22/154 (14%)
Query: 2407 RMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFI 2466
R++ V++ + ++ P PK VS ET + + L + P
Sbjct: 26175 RVKSPEAVKSPKRVKSPEPSHPK-----AVSPTETKPTPTEKVQHLPVSAP-----PKIT 26224
Query: 2467 QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
Q + E + +TC++ +V+ R K +TW + + + + Y+
Sbjct: 26225 QFLKAEASKEIAKLTCVVESSVL-------RAKE-VTWYKDGKKLKENGHFQFHYSAD-- 26274
Query: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTS 2560
G LKI NL D G Y C + + GT+ T+
Sbjct: 26275 --GTYELKINNLTESDQGEYVCEISGEGGTSKTN 26306
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 231 bits (588), Expect = 1e-59
Identities = 199/676 (29%), Positives = 311/676 (46%), Gaps = 101/676 (14%)
Query: 1119 WTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFR 1178
+ L + +D+CQ + A+ AL I++ E T +E + KEY
Sbjct: 503 YLLASQPVDKCQS----QDGAEAALQEIEKFLE------TGAENKIQELNAIYKEYES-- 550
Query: 1179 VPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKAL 1238
+ + E V+ + Q S E H ++K + + + R S +
Sbjct: 551 ILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSP 610
Query: 1239 GVNT-EDNKDLELDII---PASLSDREV-KLRDANHEVNEEKRKSARKKEFIMAELLQTE 1293
G+ +N E + P + E+ + R EE+ A + +M+ELL TE
Sbjct: 611 GIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTE 670
Query: 1294 KAYVRDLHECLETYLWEMTSGVEE--IPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKY 1351
+AYV +L LE Y EM + + + G+ NK+ ++FGN++EIY FHN IFL+ELE Y
Sbjct: 671 RAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENY 730
Query: 1352 EQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAG-TFFDEIQQRHGLANSISSY 1410
PE VG CF+ + FQ+Y YC+NKP S L + + FF E Q++ S+ SY
Sbjct: 731 TDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSY 790
Query: 1411 LIKPVQRITKYQLLLKELLTCCE--EGKGELKDGLEVMLSVPKKANDAMHVSMLEGFDEN 1468
L+KPVQRITKYQLLLKE+L EG +L++ L +L + K ND+MH+ + G+D N
Sbjct: 791 LLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGN 850
Query: 1469 LDVQGELILQDAFQVWDP--------KSLIR-KGRERHLFLFEISLVFSKEIKDS-SGHT 1518
L G+L++Q +F VW K L R K +RHLFL E +++F K+ +++ G+
Sbjct: 851 LGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYE 910
Query: 1519 K---YVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNI 1575
K Y YK L + +G+TE+V+GD KF +W + + +++A E K W+ I
Sbjct: 911 KAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYN---AREEVYIVQAPTPEIKAAWVNEI 967
Query: 1576 REVIQERIIHLKGALKE---------PLQLPKTPAKQRNNSKR----------------- 1609
R+V+ ++ + A + PL P + + R NS+
Sbjct: 968 RKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGY 1027
Query: 1610 --------------------DGVEDIDSQGDGSSQPDTISIASRTSQNTVDSDKLSGGCE 1649
+E + G SS + I+ + + KL G +
Sbjct: 1028 VSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPG-K 1086
Query: 1650 LTVVLQDFSAGHSSELTIQVGQTVELLERPSERPGWCLVRTTERSPPLEGLVPSSAL--- 1706
TVV D G L ++ G VEL++ E + TT + EG VP+S+L
Sbjct: 1087 YTVV-ADHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGK----EGWVPASSLSVR 1141
Query: 1707 --------CISHSRSS 1714
C+S S SS
Sbjct: 1142 LGPSGSAQCLSSSESS 1157
Score = 191 bits (486), Expect = 7e-48
Identities = 147/523 (28%), Positives = 250/523 (47%), Gaps = 60/523 (11%)
Query: 1919 EEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPE----DMRGKDKI 1974
EEE+ LR V++EL+ TE+ YV++L V+EG+ ++ + + K +
Sbjct: 650 EEEESLAILRRH--VMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDV 707
Query: 1975 VFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAE 2034
+FGN+ +IY +H FL ELE + + + F++ IY YCQNKPRSE + +
Sbjct: 708 LFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQ 767
Query: 2035 YD--AYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKA-GLECSDIEKAV 2091
+F+E +++++ +L+L +L+KP+QRITKYQLLLK+ L+YS G E D+++A+
Sbjct: 768 CSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAE--DLQEAL 825
Query: 2092 ELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKE------- 2144
+ + K ND M+L + G++G L GKLL Q +F V ++ KE
Sbjct: 826 SSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPM 885
Query: 2145 -RRVFLFEQIVIFSELLRKG----SLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRE 2199
R +FL E+ V+F + + P Y +K+S+ M + + ENV D KF +
Sbjct: 886 QRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNA 945
Query: 2200 TSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAVMRSQPA--- 2256
E ++QA +I+ AWV +I +VL +Q L A + +++ E+S ++ P
Sbjct: 946 REEVYIVQAPTPEIKAAWVNEIRKVLTSQ---LQACREASQHRALEQSQSLPLPAPTSTS 1002
Query: 2257 ----------RLPQASPRP-----YSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFE 2301
+L + P Y S ++ P KG ++ L+ +G
Sbjct: 1003 PSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGG---- 1058
Query: 2302 YHQPGDKFEASKQNDLGGCNG----TSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQN 2357
+ ++ +S + GG V+ D+ + + V G+VV+++ +
Sbjct: 1059 WSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEG 1118
Query: 2358 MCLVYQPASDHSPAAEGWVPGSILA----PLTKATAAESSDGS 2396
+ V P + EGWVP S L+ P A SS+ S
Sbjct: 1119 LWYVRDPTT----GKEGWVPASSLSVRLGPSGSAQCLSSSESS 1157
Score = 163 bits (412), Expect = 3e-39
Identities = 136/521 (26%), Positives = 230/521 (44%), Gaps = 51/521 (9%)
Query: 30 LKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDV 89
L A+D+ LK++ A++SGGR + G P++TFP I ++ + ++TYL S+PS
Sbjct: 94 LCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQD 153
Query: 90 CKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTN----FGSS 145
GF ++ID R KW +K + + +FPA + + L+++P F+Q+ ++ F
Sbjct: 154 AGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRD 213
Query: 146 KFIFETSMV---SVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLS 202
F + ++ SV L +D SQLTE+ G+LDY H W+ R ++E F
Sbjct: 214 DFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQ 273
Query: 203 RLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGF 262
L+ LA E P DV+ + ++ HT+ K K K + +EG +L+ +R
Sbjct: 274 MLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKA-KEDLRLALKEGHSVLESLRELQAE 332
Query: 263 SGRNCI-PGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQ---D 318
+ D Q+ V + LL +L+ T + W + KL+QC QLR FEQ +
Sbjct: 333 GSEPSVNQDQLDNQATVQR---LLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFRE 389
Query: 319 AEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRL 378
+ + D S + + T+IG S + L F S A + +L
Sbjct: 390 VKAILDAASQK----IATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQL 445
Query: 379 SEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMC 438
HYA I+ +L F+A + R +L+ S H++ E + K C
Sbjct: 446 IGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSM-------KWC 498
Query: 439 SEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEV-SQDG-KALLDVLQRPLSPGNSESL-- 494
EG +Y +Q + SQDG +A L +++ L G +
Sbjct: 499 DEG------------------IYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQE 540
Query: 495 --TATANYSKAVHQ-VLDVVHEVLHHQRRLESIWQHRKVRL 532
Y ++Q +++ V +V Q +E ++ R+ L
Sbjct: 541 LNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASL 581
Score = 58.9 bits (141), Expect = 7e-08
Identities = 73/319 (22%), Positives = 128/319 (40%), Gaps = 33/319 (10%)
Query: 803 DLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKD-IDLAAQV 861
D+ L HTE+K +++G + + + E+QA G E +D +D A V
Sbjct: 290 DVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATV 349
Query: 862 QELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNAS 921
Q LL L+E + + + ++LEQCLQLRH + ++V + + +
Sbjct: 350 QRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGN 409
Query: 922 SLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECA 981
SL+ E L R+ F+ ++++ +L +Q L+ HY D+IR
Sbjct: 410 SLAHVEHLLRDLASFEEK-----SGVAVERARALSLDGEQ----LIGNKHYAVDSIRPKC 460
Query: 982 EKVALHWQQLMLKMEDRLKLVNASVAFYK---TSEQVCSVLESLEQEYRRDEDWCGGRDK 1038
+++ Q ++ R L++ S+ ++ TS + C E + + D C +D
Sbjct: 461 QELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCD--EGIYLLASQPVDKCQSQD- 517
Query: 1039 LGPAAEIDHVIPLISKHLEQKEAFLKAC----------TLARRNAEVFLK------YIHR 1082
G A + + + E K L A L +VF K HR
Sbjct: 518 -GAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHR 576
Query: 1083 NNVSMPSVASHTRGPEQQV 1101
S+ +A+ P Q V
Sbjct: 577 RQASLKKLAARQTRPVQPV 595
Score = 56.6 bits (135), Expect = 4e-07
Identities = 75/365 (20%), Positives = 140/365 (38%), Gaps = 44/365 (12%)
Query: 407 LDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQ 466
L +R+ I + + + Q A+ S + +E LP+++Q + H ++ +
Sbjct: 255 LCQRTAIESFALMVKQTAQMLQS----FGTELAETELPNDVQSTSSVLCAHTEKKDKAKE 310
Query: 467 AYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQ 526
++G ++L+ L+ + G+ S+ ++A Q L + ++ + + W
Sbjct: 311 DLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRL--LAQLNETEAAFDEFWA 368
Query: 527 HRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEV 586
+ +L Q LQL F+Q ++V ++ + ++ T +G SL L + FEE
Sbjct: 369 KHQQKLEQCLQLRHFEQGFREVKAILDAASQK-IATFTDIGNSLAHVEHLLRDLASFEEK 427
Query: 587 AQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSF 646
+ A L EQL + I + L F + +R+ LL S+
Sbjct: 428 SGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLEL 487
Query: 647 HTHTKELWTWMED---LQKEMLEDVCA--DSVDAVQELIKQFQQQQTATLDATLNVI-KE 700
H + W ++ L D C D +A + I++F + LN I KE
Sbjct: 488 HRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKE 547
Query: 701 GEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHE 760
E ++ Q + H+ V Q+ Q MEE+FH
Sbjct: 548 YESILNQ---------------------------DLMEHVRKVFQK----QASMEEVFHR 576
Query: 761 RKIKL 765
R+ L
Sbjct: 577 RQASL 581
Score = 48.5 bits (114), Expect = 1e-04
Identities = 66/325 (20%), Positives = 136/325 (41%), Gaps = 36/325 (11%)
Query: 645 SFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDL 704
SF K+ ++ E+ E + V + ++ +++ + +KEG +
Sbjct: 263 SFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSV 322
Query: 705 IQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIK 764
++ LR EPS +D + N T ++ +L QL++ + +E + + + K
Sbjct: 323 LESLRELQAEGSEPSVNQDQ-LDNQAT--------VQRLLAQLNETEAAFDEFWAKHQQK 373
Query: 765 LDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNT--------EDLTLAEQRLQRHTE 816
L+ LQLR FEQ EV A LDA ++ + + N+ DL E++ E
Sbjct: 374 LEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVE 433
Query: 817 RKLAMNNMTFEVIQQGQDLHQYITEVQASGIEL--ICEKDIDLAAQVQELLEFLHEKQHE 874
R A++ ++I + H + ++ EL +C++ A+ + LL E
Sbjct: 434 RARALSLDGEQLI---GNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRR 490
Query: 875 LELNAE--------QTHKRLEQCLQLRHLQAEVKQVLGWIRNGE----SMLNASLVNASS 922
LE + + + +++C +A ++++ ++ G LNA S
Sbjct: 491 LETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYES 550
Query: 923 LSEAEQLQREHEQF--QLAIESLFH 945
+ + ++ + F Q ++E +FH
Sbjct: 551 ILNQDLMEHVRKVFQKQASMEEVFH 575
Score = 48.1 bits (113), Expect = 1e-04
Identities = 40/197 (20%), Positives = 80/197 (40%), Gaps = 3/197 (1%)
Query: 1044 EIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNV--SMPSVASHTRGPEQQV 1101
++ ++ H E+K+ + LA + L+ + S PSV + V
Sbjct: 290 DVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATV 349
Query: 1102 KAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTG 1161
+ +L++L + E FW +++L+QC Q FE+ ++ + I + ++T T G
Sbjct: 350 QRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFRE-VKAILDAASQKIATFTDIG 408
Query: 1162 ETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYR 1221
+ + LL++ F + E+ + L + + H IR +
Sbjct: 409 NSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCD 468
Query: 1222 DFSLRMGKYRYSLEKAL 1238
FS + + R L K+L
Sbjct: 469 QFSAEIARRRGLLSKSL 485
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 231 bits (588), Expect = 1e-59
Identities = 199/676 (29%), Positives = 311/676 (46%), Gaps = 101/676 (14%)
Query: 1119 WTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFR 1178
+ L + +D+CQ + A+ AL I++ E T +E + KEY
Sbjct: 450 YLLASQPVDKCQS----QDGAEAALQEIEKFLE------TGAENKIQELNAIYKEYES-- 497
Query: 1179 VPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKAL 1238
+ + E V+ + Q S E H ++K + + + R S +
Sbjct: 498 ILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSP 557
Query: 1239 GVNT-EDNKDLELDII---PASLSDREV-KLRDANHEVNEEKRKSARKKEFIMAELLQTE 1293
G+ +N E + P + E+ + R EE+ A + +M+ELL TE
Sbjct: 558 GIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTE 617
Query: 1294 KAYVRDLHECLETYLWEMTSGVEE--IPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKY 1351
+AYV +L LE Y EM + + + G+ NK+ ++FGN++EIY FHN IFL+ELE Y
Sbjct: 618 RAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENY 677
Query: 1352 EQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAG-TFFDEIQQRHGLANSISSY 1410
PE VG CF+ + FQ+Y YC+NKP S L + + FF E Q++ S+ SY
Sbjct: 678 TDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSY 737
Query: 1411 LIKPVQRITKYQLLLKELLTCCE--EGKGELKDGLEVMLSVPKKANDAMHVSMLEGFDEN 1468
L+KPVQRITKYQLLLKE+L EG +L++ L +L + K ND+MH+ + G+D N
Sbjct: 738 LLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGN 797
Query: 1469 LDVQGELILQDAFQVWDP--------KSLIR-KGRERHLFLFEISLVFSKEIKDS-SGHT 1518
L G+L++Q +F VW K L R K +RHLFL E +++F K+ +++ G+
Sbjct: 798 LGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYE 857
Query: 1519 K---YVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNI 1575
K Y YK L + +G+TE+V+GD KF +W + + +++A E K W+ I
Sbjct: 858 KAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYN---AREEVYIVQAPTPEIKAAWVNEI 914
Query: 1576 REVIQERIIHLKGALKE---------PLQLPKTPAKQRNNSKR----------------- 1609
R+V+ ++ + A + PL P + + R NS+
Sbjct: 915 RKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGY 974
Query: 1610 --------------------DGVEDIDSQGDGSSQPDTISIASRTSQNTVDSDKLSGGCE 1649
+E + G SS + I+ + + KL G +
Sbjct: 975 VSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPG-K 1033
Query: 1650 LTVVLQDFSAGHSSELTIQVGQTVELLERPSERPGWCLVRTTERSPPLEGLVPSSAL--- 1706
TVV D G L ++ G VEL++ E + TT + EG VP+S+L
Sbjct: 1034 YTVV-ADHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGK----EGWVPASSLSVR 1088
Query: 1707 --------CISHSRSS 1714
C+S S SS
Sbjct: 1089 LGPSGSAQCLSSSESS 1104
Score = 191 bits (486), Expect = 7e-48
Identities = 147/523 (28%), Positives = 250/523 (47%), Gaps = 60/523 (11%)
Query: 1919 EEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPE----DMRGKDKI 1974
EEE+ LR V++EL+ TE+ YV++L V+EG+ ++ + + K +
Sbjct: 597 EEEESLAILRRH--VMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDV 654
Query: 1975 VFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAE 2034
+FGN+ +IY +H FL ELE + + + F++ IY YCQNKPRSE + +
Sbjct: 655 LFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQ 714
Query: 2035 YD--AYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKA-GLECSDIEKAV 2091
+F+E +++++ +L+L +L+KP+QRITKYQLLLK+ L+YS G E D+++A+
Sbjct: 715 CSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAE--DLQEAL 772
Query: 2092 ELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKE------- 2144
+ + K ND M+L + G++G L GKLL Q +F V ++ KE
Sbjct: 773 SSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPM 832
Query: 2145 -RRVFLFEQIVIFSELLRKG----SLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRE 2199
R +FL E+ V+F + + P Y +K+S+ M + + ENV D KF +
Sbjct: 833 QRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNA 892
Query: 2200 TSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAVMRSQPA--- 2256
E ++QA +I+ AWV +I +VL +Q L A + +++ E+S ++ P
Sbjct: 893 REEVYIVQAPTPEIKAAWVNEIRKVLTSQ---LQACREASQHRALEQSQSLPLPAPTSTS 949
Query: 2257 ----------RLPQASPRP-----YSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFE 2301
+L + P Y S ++ P KG ++ L+ +G
Sbjct: 950 PSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGG---- 1005
Query: 2302 YHQPGDKFEASKQNDLGGCNG----TSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQN 2357
+ ++ +S + GG V+ D+ + + V G+VV+++ +
Sbjct: 1006 WSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEG 1065
Query: 2358 MCLVYQPASDHSPAAEGWVPGSILA----PLTKATAAESSDGS 2396
+ V P + EGWVP S L+ P A SS+ S
Sbjct: 1066 LWYVRDPTT----GKEGWVPASSLSVRLGPSGSAQCLSSSESS 1104
Score = 166 bits (420), Expect = 3e-40
Identities = 142/548 (25%), Positives = 238/548 (43%), Gaps = 59/548 (10%)
Query: 11 LWYLRLLRLLDRGSFRNDGLKASDVLPI--------LKEKVAFVSGGRDKRGGPILTFPA 62
LW L R G R D + D++P+ LK++ A++SGGR + G P++TFP
Sbjct: 14 LWSLPRRRRGTAGRSRPDEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSPVITFPD 73
Query: 63 RSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAE 122
I ++ + ++TYL S+PS GF ++ID R KW +K + + +FPA
Sbjct: 74 YPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIAASFPAN 133
Query: 123 IHVALIIKPDNFWQKQKTN----FGSSKFIFETSMV---SVEGLTKLVDPSQLTEEFDGS 175
+ + L+++P F+Q+ ++ F F + ++ SV L +D SQLTE+ G+
Sbjct: 134 LQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGT 193
Query: 176 LDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKK 235
LDY H W+ R ++E F L+ LA E P DV+ + ++ HT+ K
Sbjct: 194 LDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKD 253
Query: 236 KVLKAPVEELDREGQRLLQCIRCSDGFSGRNCI-PGSADFQSLVPKITSLLDKLHSTRQH 294
K K + +EG +L+ +R + D Q+ V + LL +L+ T
Sbjct: 254 KA-KEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQR---LLAQLNETEAA 309
Query: 295 LHQMWHVRKLKLDQCFQLRLFEQ---DAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQ 351
+ W + KL+QC QLR FEQ + + + D S + + T+IG S + L
Sbjct: 310 FDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQK----IATFTDIGNSLAHVEHLL 365
Query: 352 TQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERS 411
F S A + +L HYA I+ +L F+A + R
Sbjct: 366 RDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRR 425
Query: 412 TILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEV 471
+L+ S H++ E + K C EG +Y +Q +
Sbjct: 426 GLLSKSLELHRRLETSM-------KWCDEG------------------IYLLASQPVDKC 460
Query: 472 -SQDG-KALLDVLQRPLSPGNSESL----TATANYSKAVHQ-VLDVVHEVLHHQRRLESI 524
SQDG +A L +++ L G + Y ++Q +++ V +V Q +E +
Sbjct: 461 QSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEV 520
Query: 525 WQHRKVRL 532
+ R+ L
Sbjct: 521 FHRRQASL 528
Score = 58.9 bits (141), Expect = 7e-08
Identities = 73/319 (22%), Positives = 128/319 (40%), Gaps = 33/319 (10%)
Query: 803 DLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKD-IDLAAQV 861
D+ L HTE+K +++G + + + E+QA G E +D +D A V
Sbjct: 237 DVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATV 296
Query: 862 QELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNAS 921
Q LL L+E + + + ++LEQCLQLRH + ++V + + +
Sbjct: 297 QRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGN 356
Query: 922 SLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECA 981
SL+ E L R+ F+ ++++ +L +Q L+ HY D+IR
Sbjct: 357 SLAHVEHLLRDLASFEEK-----SGVAVERARALSLDGEQ----LIGNKHYAVDSIRPKC 407
Query: 982 EKVALHWQQLMLKMEDRLKLVNASVAFYK---TSEQVCSVLESLEQEYRRDEDWCGGRDK 1038
+++ Q ++ R L++ S+ ++ TS + C E + + D C +D
Sbjct: 408 QELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCD--EGIYLLASQPVDKCQSQD- 464
Query: 1039 LGPAAEIDHVIPLISKHLEQKEAFLKAC----------TLARRNAEVFLK------YIHR 1082
G A + + + E K L A L +VF K HR
Sbjct: 465 -GAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHR 523
Query: 1083 NNVSMPSVASHTRGPEQQV 1101
S+ +A+ P Q V
Sbjct: 524 RQASLKKLAARQTRPVQPV 542
Score = 56.6 bits (135), Expect = 4e-07
Identities = 75/365 (20%), Positives = 140/365 (38%), Gaps = 44/365 (12%)
Query: 407 LDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQ 466
L +R+ I + + + Q A+ S + +E LP+++Q + H ++ +
Sbjct: 202 LCQRTAIESFALMVKQTAQMLQS----FGTELAETELPNDVQSTSSVLCAHTEKKDKAKE 257
Query: 467 AYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQ 526
++G ++L+ L+ + G+ S+ ++A Q L + ++ + + W
Sbjct: 258 DLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRL--LAQLNETEAAFDEFWA 315
Query: 527 HRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEV 586
+ +L Q LQL F+Q ++V ++ + ++ T +G SL L + FEE
Sbjct: 316 KHQQKLEQCLQLRHFEQGFREVKAILDAASQK-IATFTDIGNSLAHVEHLLRDLASFEEK 374
Query: 587 AQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSF 646
+ A L EQL + I + L F + +R+ LL S+
Sbjct: 375 SGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLEL 434
Query: 647 HTHTKELWTWMED---LQKEMLEDVCA--DSVDAVQELIKQFQQQQTATLDATLNVI-KE 700
H + W ++ L D C D +A + I++F + LN I KE
Sbjct: 435 HRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKE 494
Query: 701 GEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHE 760
E ++ Q + H+ V Q+ Q MEE+FH
Sbjct: 495 YESILNQ---------------------------DLMEHVRKVFQK----QASMEEVFHR 523
Query: 761 RKIKL 765
R+ L
Sbjct: 524 RQASL 528
Score = 48.5 bits (114), Expect = 1e-04
Identities = 66/325 (20%), Positives = 136/325 (41%), Gaps = 36/325 (11%)
Query: 645 SFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDL 704
SF K+ ++ E+ E + V + ++ +++ + +KEG +
Sbjct: 210 SFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSV 269
Query: 705 IQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIK 764
++ LR EPS +D + N T ++ +L QL++ + +E + + + K
Sbjct: 270 LESLRELQAEGSEPSVNQDQ-LDNQAT--------VQRLLAQLNETEAAFDEFWAKHQQK 320
Query: 765 LDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNT--------EDLTLAEQRLQRHTE 816
L+ LQLR FEQ EV A LDA ++ + + N+ DL E++ E
Sbjct: 321 LEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVE 380
Query: 817 RKLAMNNMTFEVIQQGQDLHQYITEVQASGIEL--ICEKDIDLAAQVQELLEFLHEKQHE 874
R A++ ++I + H + ++ EL +C++ A+ + LL E
Sbjct: 381 RARALSLDGEQLI---GNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRR 437
Query: 875 LELNAE--------QTHKRLEQCLQLRHLQAEVKQVLGWIRNGE----SMLNASLVNASS 922
LE + + + +++C +A ++++ ++ G LNA S
Sbjct: 438 LETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYES 497
Query: 923 LSEAEQLQREHEQF--QLAIESLFH 945
+ + ++ + F Q ++E +FH
Sbjct: 498 ILNQDLMEHVRKVFQKQASMEEVFH 522
Score = 48.1 bits (113), Expect = 1e-04
Identities = 40/197 (20%), Positives = 80/197 (40%), Gaps = 3/197 (1%)
Query: 1044 EIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNV--SMPSVASHTRGPEQQV 1101
++ ++ H E+K+ + LA + L+ + S PSV + V
Sbjct: 237 DVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATV 296
Query: 1102 KAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTG 1161
+ +L++L + E FW +++L+QC Q FE+ ++ + I + ++T T G
Sbjct: 297 QRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFRE-VKAILDAASQKIATFTDIG 355
Query: 1162 ETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYR 1221
+ + LL++ F + E+ + L + + H IR +
Sbjct: 356 NSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCD 415
Query: 1222 DFSLRMGKYRYSLEKAL 1238
FS + + R L K+L
Sbjct: 416 QFSAEIARRRGLLSKSL 432
>gi|153791628 MCF.2 cell line derived transforming sequence isoform a
[Homo sapiens]
Length = 985
Score = 229 bits (585), Expect = 2e-59
Identities = 149/418 (35%), Positives = 225/418 (53%), Gaps = 37/418 (8%)
Query: 1282 KEFIMAELLQTEKAYVRDLHECLETYLWEMTSG--VEEIPPGILNKEHIIFGNIQEIYDF 1339
K ++ EL+QTE+ YVR+L+ L Y EM + + +PP + NK+ I+FGN+ EIY+F
Sbjct: 556 KNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEF 615
Query: 1340 HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAG-TFFDEIQ 1398
HN+IFL LE PE VG CF+ D FQMY YC+NKP S + +++ FF E Q
Sbjct: 616 HNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQ 675
Query: 1399 QRHGLANSISSYLIKPVQRITKYQLLLKELLTCCE--EGKGELKDGLEVMLSVPKKANDA 1456
++ + SYL+KPVQRITKYQLLLKELL + EG LK L+ ML + K ND+
Sbjct: 676 RKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVNDS 735
Query: 1457 MHVSMLEGFDENLDVQGELILQDAFQVW--------DPKSLIR-KGRERHLFLFEISLVF 1507
MH + G+ NL+ G++I+Q F VW K L R K +RHLFL+E ++VF
Sbjct: 736 MHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVF 795
Query: 1508 SKEI----KDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKAS 1563
K + S + Y +K+ E+G+TE+V+GD KF +W G + +++AS
Sbjct: 796 CKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYG---EKEEVYIVQAS 852
Query: 1564 NIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGDGSS 1623
N++ K W+K IR ++ + ++ L K +Q ++RD + Q D
Sbjct: 853 NVDVKMTWLKEIRNILLK---------QQELLTVKKRKQQDQLTERDKFQISLQQNDEKQ 903
Query: 1624 QPDTISIASRTSQNTVDSDKLSGGCELTVVLQDFSAGHSSELTIQVGQTVELLERPSE 1681
Q IS ++T ++ CE +Q ++ + + Q+ E+ E P+E
Sbjct: 904 QGAFISTEETELEHTSTVVEV---CEAIASVQ----AEANTVWTEASQSAEISEEPAE 954
Score = 192 bits (488), Expect = 4e-48
Identities = 113/335 (33%), Positives = 186/335 (55%), Gaps = 25/335 (7%)
Query: 1933 VLNELVQTEKDYVKDLGIVVEGFMKRIEEKGV----PEDMRGKDKIVFGNIHQIYDWHKD 1988
VLNEL+QTE+ YV++L V+ G+ ++ + P +R K I+FGN+ +IY++H D
Sbjct: 559 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 618
Query: 1989 FFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYD--AYFEEVKQEI 2046
FL+ LE C +R+ F++ + +Y YCQNKPRSE I +Y A+F+E ++++
Sbjct: 619 IFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKL 678
Query: 2047 NQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSD---IEKAVELMCLVPKRCND 2103
RL L +L+KP+QRITKYQLLLK+ L+YS+ +C ++KA++ M + K ND
Sbjct: 679 KHRLRLDSYLLKPVQRITKYQLLLKELLKYSK----DCEGSALLKKALDAMLDLLKSVND 734
Query: 2104 MMNLGRLQGFEGTLTAQGKLLQQDTFYV--------IELDAGMQSRTKERRVFLFEQIVI 2155
M+ + G+ G L GK++ Q F V ++ + + +R +FL+E+ ++
Sbjct: 735 SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIV 794
Query: 2156 FS----ELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANA 2211
F E P Y FK KM+ + + E V D KF + E E ++QA+N
Sbjct: 795 FCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEEVYIVQASNV 854
Query: 2212 DIQQAWVQDINQVLETQRDFLNALQSPIEYQRKER 2246
D++ W+++I +L Q++ L + + Q ER
Sbjct: 855 DVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTER 889
Score = 134 bits (337), Expect = 1e-30
Identities = 104/372 (27%), Positives = 169/372 (45%), Gaps = 26/372 (6%)
Query: 41 EKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDM 100
+ +AF+SGGR K I+TFP N I +E + K++TYL S+ ++ FT+I+D
Sbjct: 2 QDIAFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLTYLTSIARQNGSDSRFTIILDR 61
Query: 101 RGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTN----FGSSKFIFETSMV-- 154
R W +K L+ + +FP +H+ L+++P +F Q+ T+ F F+ + +V
Sbjct: 62 RLDTWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVML 121
Query: 155 -SVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLAR 213
SV L +D QLT E G+L Y H EWI R ++E F + + L+ LA
Sbjct: 122 SSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAE 181
Query: 214 KEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSD---GFSGR-NCIP 269
E P D+ ++ + + +LK + + +EG+ LL + D S R C
Sbjct: 182 TELPDDIPSIEEILAIRAE-RYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHR 240
Query: 270 G-SADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISH 328
S D+Q+ I LL ++H W +LK++Q QL FEQD +++ +
Sbjct: 241 QISGDWQT----INKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEV-- 294
Query: 329 NKELFLQSHTEI----GVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHY 384
E L E+ G Q ++ N NS ++ +L+ HY
Sbjct: 295 --EFLLNQQAELADVTGTIAQVKQKIKKLEN-LDENSQELLSKAQFVILHGHKLAANHHY 351
Query: 385 ASQQIKQISTQL 396
A I Q +L
Sbjct: 352 ALDLICQRCNEL 363
Score = 51.2 bits (121), Expect = 2e-05
Identities = 51/242 (21%), Positives = 105/242 (43%), Gaps = 19/242 (7%)
Query: 419 VFHQKAEQFLSGVDAWCKMCSEGG-------LPSEMQDLELAIHHHQTLYEQVTQAYTEV 471
+F E F V +M G LP ++ +E + Y + T V
Sbjct: 153 IFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAV 212
Query: 472 SQDGKALLDVLQRPLSPGN-SESLTATANYS---KAVHQVLDVVHEVLHHQRRLESIWQH 527
+++GK LL L+ P + G S L S + ++++L VH++ + + W+
Sbjct: 213 TKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVHDM---ETAFDGFWEK 269
Query: 528 RKVRLHQRLQLCVFQQDVQQVLDWIE--NHGEAFLSKHTGVGKSLHRARALQKRHDDFEE 585
++++ Q LQL F+QD QQ++ +E + +A L+ TG ++ + + K+ ++ +E
Sbjct: 270 HQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAELADVTG---TIAQVKQKIKKLENLDE 326
Query: 586 VAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVS 645
+Q + A ++ +LA + I + L V ++ +++ L +
Sbjct: 327 NSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDILVNEIKAKRIQLSRTFK 386
Query: 646 FH 647
H
Sbjct: 387 MH 388
Score = 45.1 bits (105), Expect = 0.001
Identities = 58/258 (22%), Positives = 109/258 (42%), Gaps = 32/258 (12%)
Query: 645 SFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDL 704
+F KE+ ++ E+ E D + +++E++ ++ + V KEG+ L
Sbjct: 160 NFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKIL 219
Query: 705 IQQLRSAPPSLGEPSEARDSAVSNNKTPH---SSSISHIESVLQQLDDAQVQMEELFHER 761
+ L P + G AVS+ H S I +L Q+ D + + + +
Sbjct: 220 LTNLE-VPDTEG--------AVSSRLECHRQISGDWQTINKLLTQVHDMETAFDGFWEKH 270
Query: 762 KIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAE-----QRLQRHTE 816
++K++ +LQL FEQ ++ E+ E LL Q + T+A+ ++L+ E
Sbjct: 271 QLKMEQYLQLWKFEQDFQQLVTEV----EFLLNQQAELADVTGTIAQVKQKIKKLENLDE 326
Query: 817 RKLAMNNMTFEVIQQGQDL---HQYITEVQASGIELICEKDIDLAAQVQELLEFLHEKQH 873
+ + VI G L H Y ++LIC++ +L L+ + K+
Sbjct: 327 NSQELLSKAQFVILHGHKLAANHHY-------ALDLICQRCNELRYLSDILVNEIKAKRI 379
Query: 874 ELELNAEQTHKRLEQCLQ 891
+L + HK L+Q Q
Sbjct: 380 QLS-RTFKMHKLLQQARQ 396
>gi|153791325 MCF.2 cell line derived transforming sequence isoform b
[Homo sapiens]
Length = 925
Score = 229 bits (585), Expect = 2e-59
Identities = 149/418 (35%), Positives = 225/418 (53%), Gaps = 37/418 (8%)
Query: 1282 KEFIMAELLQTEKAYVRDLHECLETYLWEMTSG--VEEIPPGILNKEHIIFGNIQEIYDF 1339
K ++ EL+QTE+ YVR+L+ L Y EM + + +PP + NK+ I+FGN+ EIY+F
Sbjct: 496 KNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEF 555
Query: 1340 HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAG-TFFDEIQ 1398
HN+IFL LE PE VG CF+ D FQMY YC+NKP S + +++ FF E Q
Sbjct: 556 HNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQ 615
Query: 1399 QRHGLANSISSYLIKPVQRITKYQLLLKELLTCCE--EGKGELKDGLEVMLSVPKKANDA 1456
++ + SYL+KPVQRITKYQLLLKELL + EG LK L+ ML + K ND+
Sbjct: 616 RKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVNDS 675
Query: 1457 MHVSMLEGFDENLDVQGELILQDAFQVW--------DPKSLIR-KGRERHLFLFEISLVF 1507
MH + G+ NL+ G++I+Q F VW K L R K +RHLFL+E ++VF
Sbjct: 676 MHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVF 735
Query: 1508 SKEI----KDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKAS 1563
K + S + Y +K+ E+G+TE+V+GD KF +W G + +++AS
Sbjct: 736 CKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYG---EKEEVYIVQAS 792
Query: 1564 NIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGDGSS 1623
N++ K W+K IR ++ + ++ L K +Q ++RD + Q D
Sbjct: 793 NVDVKMTWLKEIRNILLK---------QQELLTVKKRKQQDQLTERDKFQISLQQNDEKQ 843
Query: 1624 QPDTISIASRTSQNTVDSDKLSGGCELTVVLQDFSAGHSSELTIQVGQTVELLERPSE 1681
Q IS ++T ++ CE +Q ++ + + Q+ E+ E P+E
Sbjct: 844 QGAFISTEETELEHTSTVVEV---CEAIASVQ----AEANTVWTEASQSAEISEEPAE 894
Score = 192 bits (488), Expect = 4e-48
Identities = 113/335 (33%), Positives = 186/335 (55%), Gaps = 25/335 (7%)
Query: 1933 VLNELVQTEKDYVKDLGIVVEGFMKRIEEKGV----PEDMRGKDKIVFGNIHQIYDWHKD 1988
VLNEL+QTE+ YV++L V+ G+ ++ + P +R K I+FGN+ +IY++H D
Sbjct: 499 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 558
Query: 1989 FFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYD--AYFEEVKQEI 2046
FL+ LE C +R+ F++ + +Y YCQNKPRSE I +Y A+F+E ++++
Sbjct: 559 IFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKL 618
Query: 2047 NQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSD---IEKAVELMCLVPKRCND 2103
RL L +L+KP+QRITKYQLLLK+ L+YS+ +C ++KA++ M + K ND
Sbjct: 619 KHRLRLDSYLLKPVQRITKYQLLLKELLKYSK----DCEGSALLKKALDAMLDLLKSVND 674
Query: 2104 MMNLGRLQGFEGTLTAQGKLLQQDTFYV--------IELDAGMQSRTKERRVFLFEQIVI 2155
M+ + G+ G L GK++ Q F V ++ + + +R +FL+E+ ++
Sbjct: 675 SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIV 734
Query: 2156 FS----ELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANA 2211
F E P Y FK KM+ + + E V D KF + E E ++QA+N
Sbjct: 735 FCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEEVYIVQASNV 794
Query: 2212 DIQQAWVQDINQVLETQRDFLNALQSPIEYQRKER 2246
D++ W+++I +L Q++ L + + Q ER
Sbjct: 795 DVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTER 829
Score = 85.5 bits (210), Expect = 7e-16
Identities = 77/295 (26%), Positives = 126/295 (42%), Gaps = 26/295 (8%)
Query: 118 AFPAEIHVALIIKPDNFWQKQKTNFG----SSKFIFETSMV---SVEGLTKLVDPSQLTE 170
+FP +H+ L+++P +F Q+ T+ G F+ + +V SV L +D QLT
Sbjct: 19 SFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTP 78
Query: 171 EFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEH 230
E G+L Y H EWI R ++E F + + L+ LA E P D+ ++
Sbjct: 79 ELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIR 138
Query: 231 TQLKKKVLKAPVEELDREGQRLLQCIRCSD---GFSGR-NCIPG-SADFQSLVPKITSLL 285
+ + +LK + + +EG+ LL + D S R C S D+Q+ I LL
Sbjct: 139 AE-RYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQT----INKLL 193
Query: 286 DKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEI----G 341
++H W +LK++Q QL FEQD +++ + E L E+ G
Sbjct: 194 TQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEV----EFLLNQQAELADVTG 249
Query: 342 VSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQL 396
Q ++ N NS ++ +L+ HYA I Q +L
Sbjct: 250 TIAQVKQKIKKLEN-LDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNEL 303
Score = 51.2 bits (121), Expect = 2e-05
Identities = 51/242 (21%), Positives = 105/242 (43%), Gaps = 19/242 (7%)
Query: 419 VFHQKAEQFLSGVDAWCKMCSEGG-------LPSEMQDLELAIHHHQTLYEQVTQAYTEV 471
+F E F V +M G LP ++ +E + Y + T V
Sbjct: 93 IFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAV 152
Query: 472 SQDGKALLDVLQRPLSPGN-SESLTATANYS---KAVHQVLDVVHEVLHHQRRLESIWQH 527
+++GK LL L+ P + G S L S + ++++L VH++ + + W+
Sbjct: 153 TKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVHDM---ETAFDGFWEK 209
Query: 528 RKVRLHQRLQLCVFQQDVQQVLDWIE--NHGEAFLSKHTGVGKSLHRARALQKRHDDFEE 585
++++ Q LQL F+QD QQ++ +E + +A L+ TG ++ + + K+ ++ +E
Sbjct: 210 HQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAELADVTG---TIAQVKQKIKKLENLDE 266
Query: 586 VAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVS 645
+Q + A ++ +LA + I + L V ++ +++ L +
Sbjct: 267 NSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDILVNEIKAKRIQLSRTFK 326
Query: 646 FH 647
H
Sbjct: 327 MH 328
Score = 45.1 bits (105), Expect = 0.001
Identities = 58/258 (22%), Positives = 109/258 (42%), Gaps = 32/258 (12%)
Query: 645 SFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDL 704
+F KE+ ++ E+ E D + +++E++ ++ + V KEG+ L
Sbjct: 100 NFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKIL 159
Query: 705 IQQLRSAPPSLGEPSEARDSAVSNNKTPH---SSSISHIESVLQQLDDAQVQMEELFHER 761
+ L P + G AVS+ H S I +L Q+ D + + + +
Sbjct: 160 LTNLE-VPDTEG--------AVSSRLECHRQISGDWQTINKLLTQVHDMETAFDGFWEKH 210
Query: 762 KIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAE-----QRLQRHTE 816
++K++ +LQL FEQ ++ E+ E LL Q + T+A+ ++L+ E
Sbjct: 211 QLKMEQYLQLWKFEQDFQQLVTEV----EFLLNQQAELADVTGTIAQVKQKIKKLENLDE 266
Query: 817 RKLAMNNMTFEVIQQGQDL---HQYITEVQASGIELICEKDIDLAAQVQELLEFLHEKQH 873
+ + VI G L H Y ++LIC++ +L L+ + K+
Sbjct: 267 NSQELLSKAQFVILHGHKLAANHHY-------ALDLICQRCNELRYLSDILVNEIKAKRI 319
Query: 874 ELELNAEQTHKRLEQCLQ 891
+L + HK L+Q Q
Sbjct: 320 QLS-RTFKMHKLLQQARQ 336
>gi|188528641 SEC14 and spectrin domains 1 [Homo sapiens]
Length = 696
Score = 229 bits (583), Expect = 4e-59
Identities = 173/659 (26%), Positives = 304/659 (46%), Gaps = 34/659 (5%)
Query: 30 LKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDV 89
++AS +LPILK+K+AF+SGG+D+R G ILT P ++ ++L + YL S+PSE
Sbjct: 1 MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCL--EQTNMDELSVTLDYLLSIPSEKC 58
Query: 90 CKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNF----GSS 145
RGFTVI+D R S+W+++K ++ LQ PAE+ + ++KPD FW K+ T+F
Sbjct: 59 KARGFTVIVDGRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKD 118
Query: 146 KFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLE 205
+ FE +VS LT+ ++P QLTE+F GSL Y+H +W+ RL E+F + LL L
Sbjct: 119 RLGFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELA 178
Query: 206 DLQE-----MLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSD 260
+ KE VD+ +D T VL+ E L QR +
Sbjct: 179 LINNGSDKGNQQEKERSVDL-NFLPSVDPET-----VLQTGHELLSELQQRRF------N 226
Query: 261 GFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAE 320
G G D P++ LLD L ++ R + QL +Q
Sbjct: 227 GSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRT----QLEEIQQKVM 282
Query: 321 KMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMN---AYVNINRIMSVASR 377
++ +W+ L++ IG S + + LQ +H YV +N+ +A+
Sbjct: 283 QVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQ--QIAAL 340
Query: 378 LSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKM 437
L+ ++K + QL A+ L+ R +L + FH A+ +D M
Sbjct: 341 LNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGM 400
Query: 438 CSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTAT 497
P++ ++ + + + V + + G+ LLD + S + + T
Sbjct: 401 LCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDV--T 458
Query: 498 ANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGE 557
+ V + V+ ++ ++R E + R++++ Q +QL ++D Q ++W+ +
Sbjct: 459 IENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLD 518
Query: 558 AFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYK 617
A L H +G + L ++H F +VAQ+TY +LL+A L Q+ C
Sbjct: 519 ALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGD 578
Query: 618 AARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAV 676
L + F E+R L+M+++FH++ +++ + + + ++ D ++AV
Sbjct: 579 TLPRLNRVWKQFTIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAV 637
Score = 77.8 bits (190), Expect = 1e-13
Identities = 104/504 (20%), Positives = 215/504 (42%), Gaps = 51/504 (10%)
Query: 773 IFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTF----EV 828
+FE++T E T+ LD L +N+ + ++ Q+ ER + +N + V
Sbjct: 162 VFEKFTKESTSLLDE-----LALINNGS-------DKGNQQEKERSVDLNFLPSVDPETV 209
Query: 829 IQQGQDLHQYITEVQASGIE---LICEKDIDLAAQ--VQELLEFLHEKQHELELNAEQTH 883
+Q G +L + + + +G + D +L AQ V +LL+ L E+ + Q
Sbjct: 210 LQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRS 269
Query: 884 KRLEQCLQLRHLQAEVKQVLGWIRN-GESMLNASLVNASSLSEAEQLQREHEQFQLAIES 942
KR QL +Q +V QV+ W+ G L A S+ ++ LQ++HE+ +
Sbjct: 270 KRT----QLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSE 325
Query: 943 LFHATSLQKTHQSALQVQQKAEVLLQAG-HYDADAIRECAEKVALHWQQLMLKMEDRLKL 1001
F +++ Q+ LL AG D ++ ++++ + ++E R L
Sbjct: 326 WFAVY---------VELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNL 376
Query: 1002 VNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEA 1061
+ A++ F+ ++ + L+ L D G A I + L+ + L+ +
Sbjct: 377 LQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADG-------ASIQQTLKLLEEKLKSVDV 429
Query: 1062 FLKACTLARRNAEVFLKYIHRNNVSMP---SVASHTRGPEQQVKAILSELLQRENRVLHF 1118
L+ R + L I N S V + ++ ++ ++ R+ R
Sbjct: 430 GLQGL---REKGQGLLDQIS-NQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDM 485
Query: 1119 WTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFR 1178
+++ ++ Q Q E A QA++W+ E + L TH G+ +ET+ LL+++ +F
Sbjct: 486 VDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFV 545
Query: 1179 VPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKAL 1238
A+ T + + L+Q + + + +++ ++ F++ + + LE A+
Sbjct: 546 DVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRLEMAI 605
Query: 1239 GVNTEDNKDL-ELDIIPASLSDRE 1261
++ K L + P +++D E
Sbjct: 606 AFHSNAEKILQDCPEEPEAINDEE 629
Score = 74.7 bits (182), Expect = 1e-12
Identities = 77/316 (24%), Positives = 132/316 (41%), Gaps = 37/316 (11%)
Query: 178 YNHEEWIELRLSLE----EFFNSAVHLLSRLEDLQEMLARKEFPVD---VEGSRRLIDEH 230
Y +E R +L EF A L +L+ L ML P D ++ + +L++E
Sbjct: 364 YRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEE- 422
Query: 231 TQLKKKVLKAPVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHS 290
K K + ++ L +GQ LL I ++ + + + + V I +++ +
Sbjct: 423 ---KLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDV--TIENKENVDHIQGVMEDMQL 477
Query: 291 TRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDL 350
+Q M VR+LK+ Q QL E+DA + +W+S + L++H +G Q L
Sbjct: 478 RKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVL 537
Query: 351 QTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDER 410
+H F + + Y +++ L ++ S+ +L++ WK F A +ER
Sbjct: 538 LEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEER 597
Query: 411 STILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTE 470
L M+ FH AE+ L C E P + D E + E
Sbjct: 598 VHRLEMAIAFHSNAEKILQD-------CPEE--PEAINDEE---------------QFDE 633
Query: 471 VSQDGKALLDVLQRPL 486
+ GK+LLD L P+
Sbjct: 634 IEAVGKSLLDRLTVPV 649
>gi|14670383 death-associated kinase 2 [Homo sapiens]
Length = 370
Score = 228 bits (582), Expect = 5e-59
Identities = 109/272 (40%), Positives = 167/272 (61%), Gaps = 8/272 (2%)
Query: 2677 KENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKK-------KEQAAHEA 2729
++ + Y E+G G+F+IVKKC K+T + A KF+ K+ + +E+ E
Sbjct: 16 QQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREV 75
Query: 2730 ALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIME 2789
++L+ + H ITLHD YE+ T +LILEL+ G L D+L + L EE+ +I+ I++
Sbjct: 76 SILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILD 135
Query: 2790 ALQYLHNCRVAHLDIKPENL-LIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAA 2848
+ YLH ++AH D+KPEN+ L+D IP+P +KLID A +I ++ G PEF A
Sbjct: 136 GVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVA 195
Query: 2849 PEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVS 2908
PE++ P+ L D+WSIGV+TY++LSG SPFL ++K+ET N+ V + F E+F S
Sbjct: 196 PEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTS 255
Query: 2909 NAARDFINVILQEDFRRRPTAATCLQHPWLQP 2940
A+DFI +L ++ R+R T L+HPW+ P
Sbjct: 256 ELAKDFIRKLLVKETRKRLTIQEALRHPWITP 287
>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
Length = 414
Score = 200 bits (508), Expect = 2e-50
Identities = 107/294 (36%), Positives = 175/294 (59%), Gaps = 11/294 (3%)
Query: 2689 EIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKE---QAAHEAALLQHLQ-HPQYITLH 2744
E+GRG+F++V+KCI K + K+ A KF+ K+ K ++ + HE A+L+ Q +P I LH
Sbjct: 66 ELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLH 125
Query: 2745 DTYESPTSYILILELMDDGRLLDYLM-NHDELMEEK-VAFYIRDIMEALQYLHNCRVAHL 2802
+ YE+ + IL+LE G + D + + +E +EK V +R I+E + +LH V HL
Sbjct: 126 EVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHL 185
Query: 2803 DIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTD 2862
D+KP+N+L+ P+ +K++D + + + ++G PE+ APE++ P+S+ TD
Sbjct: 186 DLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATD 245
Query: 2863 IWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQED 2922
+WSIGVLTYVML+G+SPFL K+ET +N+ +++ S+ E F +S +A DFI +L +
Sbjct: 246 MWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKK 305
Query: 2923 FRRRPTAATCLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQNDVRPIPNVKS 2976
R TA CL+HPWL + S I + R+ +E + +P + S
Sbjct: 306 PEDRATAEECLKHPWL-----TQSSIQEPSFRMEKALEEANALQEGHSVPEINS 354
>gi|148529025 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4B [Homo sapiens]
Length = 1271
Score = 199 bits (507), Expect = 3e-50
Identities = 117/334 (35%), Positives = 178/334 (53%), Gaps = 14/334 (4%)
Query: 1254 PASLSDREVKLRDANHEVNEEKRKS--ARKKEFIMAELLQTEKAYVRDLHECLETYLWEM 1311
P R + H E+ R+ + + IMAE++ TE+ Y+R L ++ Y EM
Sbjct: 776 PPVTQSRSLSSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEM 835
Query: 1312 TSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQM 1371
++P G+ K H+IFGN+++++DFH FL+ELE+ + P VG F+ ++F M
Sbjct: 836 ER--MDLPQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGM 893
Query: 1372 YVTYCKNKPDSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTC 1431
YV Y KNKP S+ L+ H FF + Q+ G ++SYL++PVQR+ KY LLL++LL
Sbjct: 894 YVIYSKNKPQSDALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKE 953
Query: 1432 CEEG------KGELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWD 1485
G GEL+ V+ + ND + + + G D NL QG+L +D F V
Sbjct: 954 ASCGLAQGQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIV-- 1011
Query: 1486 PKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFA 1545
RK RH+FLFE ++FSK K H Y+YK T+E+G+TE+V +F
Sbjct: 1012 --CCGRKKYLRHVFLFEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFE 1069
Query: 1546 LWSGRTPSSDNKTVLKASNIETKQEWIKNIREVI 1579
+W R S + +L+AS+ E K W I ++
Sbjct: 1070 IWFRRRRKSQDTYILQASSAEVKSAWTDVIGRIL 1103
Score = 181 bits (458), Expect = 1e-44
Identities = 93/338 (27%), Positives = 195/338 (57%), Gaps = 13/338 (3%)
Query: 1899 KDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRM-FVLNELVQTEKDYVKDLGIVVEGFMK 1957
+ P + ++ P+ EE+ + + R+ ++ E++ TE++Y++ LG V++ +
Sbjct: 774 RSPPVTQSRSLSSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFP 833
Query: 1958 RIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHI 2017
+E +P+ +RGK ++FGN+ +++D+H+ FL ELE+C + + F++HE + +
Sbjct: 834 EMERMDLPQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGM 893
Query: 2018 YVWYCQNKPRSEYIVAEY-DAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRY 2076
YV Y +NKP+S+ +++ + +A+F++ ++E+ ++ L+ +L++P+QR+ KY LLL+D L+
Sbjct: 894 YVIYSKNKPQSDALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKE 953
Query: 2077 SE---KAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIE 2133
+ G E ++ A ++C + ND++ + ++G + L QG+L +D F V
Sbjct: 954 ASCGLAQGQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVC- 1012
Query: 2134 LDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKF 2193
+ R VFLFE +++FS+ + Y++K+S K + + ENV + +F
Sbjct: 1013 ----CGRKKYLRHVFLFEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRF 1068
Query: 2194 AL---MNRETSERVVLQAANADIQQAWVQDINQVLETQ 2228
+ R++ + +LQA++A+++ AW I ++L Q
Sbjct: 1069 EIWFRRRRKSQDTYILQASSAEVKSAWTDVIGRILWRQ 1106
Score = 77.4 bits (189), Expect = 2e-13
Identities = 73/282 (25%), Positives = 126/282 (44%), Gaps = 29/282 (10%)
Query: 38 ILKEKVAFVSGGRDKRGGPILTFPARS---NHDRIRQEDLRKLVTYLASVPSEDVCKRGF 94
+L+ V + G RD+ G ++ RS + +L +L+ Y S+P ++V G
Sbjct: 197 LLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGL 256
Query: 95 TVIIDMRGSKW-DLIKPLLKTLQEAFPAEIH-VALIIKPDNFWQKQKTNFGSSKFIFETS 152
V++D R S + L LQ IH + L++ ++ ++ K I +
Sbjct: 257 VVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDKESAFRPDKDA------IIQCE 310
Query: 153 MVS-VEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEML 211
+VS ++ + K VD QLT + DGS Y+H +WI R LE F + + L++ L
Sbjct: 311 VVSSLKAVHKFVDSCQLTADLDGSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSL 370
Query: 212 ARKEFPVDVEGSRRLIDEHTQLKKKVLKAP-VEELDREGQRLLQCIRCSDGFSGRNCIPG 270
P + LID+H + K VL+ P + L EG +L +R + G
Sbjct: 371 NTHRTPRTAQEVAELIDQHETMMKLVLEDPLLVSLRLEGGTVLARLRREE--------LG 422
Query: 271 SADFQSLVPKITSLLDKLH--------STRQHLHQMWHVRKL 304
+ D + + TSL D++ ++ L Q+ H+R+L
Sbjct: 423 TEDSRDTLEAATSLYDRVDEEVHRLVLTSNNRLQQLEHLREL 464
>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform b [Homo sapiens]
Length = 7968
Score = 196 bits (499), Expect = 2e-49
Identities = 154/507 (30%), Positives = 232/507 (45%), Gaps = 29/507 (5%)
Query: 2470 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG 2529
AP FL L D T +LG +V L C+V +P TW + SS+ +S+
Sbjct: 7462 APTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPL----ESSSRVLISATLKN 7517
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRW 2589
L I ++ +D G+YTC +N GT +T+ ++ P++ P E V+L W
Sbjct: 7518 FQLLTILVVVAEDLGVYTCSVSNALGTVTTTGVLRKAERPSSSPCPDIGEVYADGVLLVW 7577
Query: 2590 LPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWG 2649
P S G T Y V+ EG W + D + LS G Y FR + + G
Sbjct: 7578 KPVESYGPVT---YIVQCSLEGGS-WTTLASDIFDCCYLTSKLSRGGTYTFRTACVSKAG 7633
Query: 2650 ISLPSEPSEFVRL--PEYDAAADGATISWKENFDSAYTEL--NEIGRGRFSIVKKCIHKA 2705
+ S PSE V L P + A+ + + + S T +I RGRFS+V++C KA
Sbjct: 7634 MGPYSSPSEQVLLGGPSHLASEEESQGRSAQPLPSTKTFAFQTQIQRGRFSVVRQCWEKA 7693
Query: 2706 TRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELMDDGRL 2765
+ + +A K + K K E L+ L+HP LH Y SP +LILEL L
Sbjct: 7694 SGRALAAKIIPYHPKDKTAVLREYEALKGLRHPHLAQLHAAYLSPRHLVLILELCSGPEL 7753
Query: 2766 LDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDL 2825
L L E +V Y+ ++ A QYLHN + HLD++ EN++I +K++DL
Sbjct: 7754 LPCLAERASYSESEVKDYLWQMLSATQYLHNQHILHLDLRSENMII---TEYNLLKVVDL 7810
Query: 2826 EDAVQISGHFHIHHLLGNPEF------AAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSP 2879
+A +S +L + +F APE+++G TDIW+IGV ++MLS P
Sbjct: 7811 GNAQSLSQ----EKVLPSDKFKDYLETMAPELLEGQGAVPQTDIWAIGVTAFIMLSAEYP 7866
Query: 2880 FLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQ 2939
E + + R + G+S A F+ L RP A++CLQ PWL
Sbjct: 7867 VSSEGARDLQRGL-RKGLVRLSRCYAGLSGGAVAFLRSTLCAQPWGRPCASSCLQCPWLT 7925
Query: 2940 PHNGSYSK---IPLDTSRLACFIERRK 2963
+ S+ + T+RL F+ R+
Sbjct: 7926 EEGPACSRPAPVTFPTARLRVFVRNRE 7952
Score = 174 bits (440), Expect = 2e-42
Identities = 112/316 (35%), Positives = 160/316 (50%), Gaps = 4/316 (1%)
Query: 2666 DAAADGATISWKENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQA 2725
D D S + S Y EIGRG F VK+ HK + A KF+ + + + QA
Sbjct: 6450 DNEPDSEKQSHRRKLHSFYEVKEEIGRGVFGFVKRVQHKGNKILCAAKFIPLRSRTRAQA 6509
Query: 2726 AHEAALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIR 2785
E +L L HP L D +E+ + ILILEL LLD L + E +V YI+
Sbjct: 6510 YRERDILAALSHPLVTGLLDQFETRKTLILILELCSSEELLDRLYRKGVVTEAEVKVYIQ 6569
Query: 2786 DIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPE 2845
++E L YLH+ V HLDIKP N+L+ + +K+ D A I+ G+PE
Sbjct: 6570 QLVEGLHYLHSHGVLHLDIKPSNILM-VHPAREDIKICDFGFAQNITPAELQFSQYGSPE 6628
Query: 2846 FAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFC 2905
F +PE+IQ PVS +DIW++GV++Y+ L+ SPF ES T +NV S+
Sbjct: 6629 FVSPEIIQQNPVSEASDIWAMGVISYLSLTCSSPFAGESDRATLLNVLEGRVSWSSPMAA 6688
Query: 2906 GVSNAARDFINVILQEDFRRRPTAATCLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQ 2965
+S A+DFI LQ + RP+AA CL HPW + ++T +L + R + Q
Sbjct: 6689 HLSEDAKDFIKATLQRAPQARPSAAQCLSHPWFLKSMPAEEAHFINTKQLKFLLARSRWQ 6748
Query: 2966 NDVRPIPNVKSYIVNR 2981
R + + KS +V R
Sbjct: 6749 ---RSLMSYKSILVMR 6761
Score = 134 bits (336), Expect = 2e-30
Identities = 97/329 (29%), Positives = 172/329 (52%), Gaps = 23/329 (6%)
Query: 1271 VNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIF 1330
V+E++ K+ + ++ ELL +E+A+V +L + L+++ + +P + ++ +IF
Sbjct: 5685 VSEDEYKA--RLSSVIQELLSSEQAFVEEL-QFLQSHHLQHLERCPHVPIAVAGQKAVIF 5741
Query: 1331 GNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHA 1390
N+++I FH++ FL+EL++ + +DV CF+ F+ Y+ + + + +++ A
Sbjct: 5742 RNVRDIGRFHSS-FLQELQQCDT-DDDVAMCFIKNQAAFEQYLEFLVGRVQAESVVVSTA 5799
Query: 1391 -GTFFDEIQQRHGLANSISS--------YLIKPVQRITKYQLLLKELLTCCEEGKGE--- 1438
F+ + + LA S YL +PV+R+ +YQ LLKEL+ +
Sbjct: 5800 IQEFYKKYAEEALLAGDPSQPPPPPLQHYLEQPVERVQRYQALLKELIRNKARNRQNCAL 5859
Query: 1439 LKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIR---KGRE 1495
L+ V+ ++P++A + +HVS++E + L GE I Q F VW+ R KG
Sbjct: 5860 LEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEGAPGARMPWKGHN 5919
Query: 1496 RHLFLFEISLVFSKEIKDSSGHT-KYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSS 1554
RH+FLF LV K +DS T YV++N + S + + + VEGD F +W R S
Sbjct: 5920 RHVFLFRNHLVICKPRRDSRTDTVSYVFRNMMKLSSIDLNDQVEGDDRAFEVWQER-EDS 5978
Query: 1555 DNKTVLKASNIETKQEWIKNIREVIQERI 1583
K +L+A K W+K I IQ+R+
Sbjct: 5979 VRKYLLQARTAIIKSSWVKEICG-IQQRL 6006
Score = 114 bits (286), Expect = 1e-24
Identities = 87/320 (27%), Positives = 164/320 (51%), Gaps = 24/320 (7%)
Query: 1919 EEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEE-KGVPEDMRGKDKIVFG 1977
E+E KA+ V+ EL+ +E+ +V++L + ++ +E VP + G+ ++F
Sbjct: 5687 EDEYKARLSS----VIQELLSSEQAFVEELQFLQSHHLQHLERCPHVPIAVAGQKAVIFR 5742
Query: 1978 NIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDA 2037
N+ I +H F L EL++C + D +A FIK++ Y+ + + ++E +V A
Sbjct: 5743 NVRDIGRFHSSF-LQELQQCDTDDD-VAMCFIKNQAAFEQYLEFLVGRVQAESVVVS-TA 5799
Query: 2038 YFEEVKQEINQRLTLSD-----------FLIKPIQRITKYQLLLKDFLRYSEKAGLECSD 2086
E K+ + L D +L +P++R+ +YQ LLK+ +R + C+
Sbjct: 5800 IQEFYKKYAEEALLAGDPSQPPPPPLQHYLEQPVERVQRYQALLKELIRNKARNRQNCAL 5859
Query: 2087 IEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAG--MQSRTKE 2144
+E+A ++ +P+R + +++ ++ + GTL A G+ ++Q F V E G M +
Sbjct: 5860 LEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEGAPGARMPWKGHN 5919
Query: 2145 RRVFLFEQIVIFSELLRKGSL-TPGYMFKRSIKMNYLVLEENVDNDPCKFAL-MNRETSE 2202
R VFLF ++ + R T Y+F+ +K++ + L + V+ D F + RE S
Sbjct: 5920 RHVFLFRNHLVICKPRRDSRTDTVSYVFRNMMKLSSIDLNDQVEGDDRAFEVWQEREDSV 5979
Query: 2203 R-VVLQAANADIQQAWVQDI 2221
R +LQA A I+ +WV++I
Sbjct: 5980 RKYLLQARTAIIKSSWVKEI 5999
Score = 58.5 bits (140), Expect = 9e-08
Identities = 47/150 (31%), Positives = 64/150 (42%), Gaps = 7/150 (4%)
Query: 2515 DNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNR 2574
D+S T T D L + + P +G T A D SA + V G+P P
Sbjct: 4476 DDSDWTVTA---DGSHHALLLRSAQPHHAGEVT-FACRD---AVASARLTVLGLPDPPED 4528
Query: 2575 PIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSP 2634
RS +V L W P S G + GY VE +E + W+ V++ L+P
Sbjct: 4529 AEVVARSSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGPECVVDGLAP 4588
Query: 2635 GCPYQFRVSASNPWGISLPSEPSEFVRLPE 2664
G Y+FRV+A P G P + VRL E
Sbjct: 4589 GETYRFRVAAVGPVGAGEPVHLPQTVRLAE 4618
Score = 54.3 bits (129), Expect = 2e-06
Identities = 32/98 (32%), Positives = 49/98 (50%), Gaps = 4/98 (4%)
Query: 2468 EVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCD 2527
+ AP FL L + G V C V G+P P++ W D +L+ D+ Y ++
Sbjct: 5123 DAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWF-KDGKLLEEDDH---YMINEDQ 5178
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV 2565
G L I ++P D G+Y C+A N G +ST A ++V
Sbjct: 5179 QGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRV 5216
Score = 54.3 bits (129), Expect = 2e-06
Identities = 36/104 (34%), Positives = 48/104 (46%), Gaps = 4/104 (3%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P+F L D T LG+TV L C+V G PKP I+W D + D + + G
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWY-KDGKAVQVD---PHHILIEDPDGS 6069
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNR 2574
L + +L DSG Y C A + G ST + VQ P N+
Sbjct: 6070 CALILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRFVNK 6113
Score = 51.2 bits (121), Expect = 2e-05
Identities = 41/157 (26%), Positives = 72/157 (45%), Gaps = 7/157 (4%)
Query: 2467 QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITW--KGPDQNILDTDNSSATYTVS 2524
Q V P L G ++ KV GRP PT+ W + ++ +L + YTV+
Sbjct: 5367 QLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVA 5426
Query: 2525 SCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTS 2584
S + + +L + ++ Q G YTCIA+N G SA++ V G+P QE+ +
Sbjct: 5427 S-SAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGLPKVEE----QEKVKEA 5481
Query: 2585 VILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVAS 2621
+I +L ++ T + + G Q ++ +A+
Sbjct: 5482 LISTFLQGTTQAISAQGLETASFADLGGQRKEEPLAA 5518
Score = 45.1 bits (105), Expect = 0.001
Identities = 43/171 (25%), Positives = 69/171 (40%), Gaps = 9/171 (5%)
Query: 2484 LGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDS 2543
+GDT + C P + W + ++ + S + TL I +D
Sbjct: 434 VGDTAMF-CVELAVPVGPVHWLRNQEEVV-----AGGRVAISAEGTRHTLTISQCCLEDV 487
Query: 2544 GIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWL-PPSSTGNCTISG 2602
G +A + +T + + P P+ + R +SVIL W PP TI G
Sbjct: 488 GQVAFMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGERPVTIDG 547
Query: 2603 YTVEYREEGSQIWQQ--SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGIS 2651
Y VE ++ G+ W + L + D++ +QFRVSA N +G S
Sbjct: 548 YLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQS 598
Score = 45.1 bits (105), Expect = 0.001
Identities = 28/111 (25%), Positives = 51/111 (45%), Gaps = 8/111 (7%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P V + DV G T + + G P+P++TW ++D+ S +
Sbjct: 6357 PSMQVTIEDVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLVDSTRLS-----QQQEGTT 6411
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERS 2581
+L + ++ +D+G+YTC+A N G A + V G N P ++++S
Sbjct: 6412 YSLVLRHVASKDAGVYTCLAQNTGGQVLCKAELLVLG---GDNEPDSEKQS 6459
Score = 44.3 bits (103), Expect = 0.002
Identities = 33/101 (32%), Positives = 43/101 (42%), Gaps = 7/101 (6%)
Query: 2481 TCLL--GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNL 2538
TC + G L C V G PKP WK Q + + + V LKI
Sbjct: 246 TCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTE----GRRHVVYEDAQENFVLKILFC 301
Query: 2539 MPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQE 2579
D G+YTC A+N G T +S V V+ PA P + Q+
Sbjct: 302 KQSDRGLYTCTASNLVGQTYSSVLVVVR-EPAVPFKKRLQD 341
Score = 42.0 bits (97), Expect = 0.009
Identities = 28/99 (28%), Positives = 44/99 (44%), Gaps = 5/99 (5%)
Query: 2468 EVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCD 2527
E AP FL+ + G +C+V G P+P ++W + + + D V +
Sbjct: 107 EQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGP----RVRVEE 162
Query: 2528 SGEIT-LKICNLMPQDSGIYTCIATNDHGTTSTSATVKV 2565
GE + L+I P+D G Y A N G S +A + V
Sbjct: 163 LGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVV 201
Score = 42.0 bits (97), Expect = 0.009
Identities = 39/147 (26%), Positives = 61/147 (41%), Gaps = 18/147 (12%)
Query: 2468 EVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCD 2527
+V P F+ + + G+ C + G P P I W D +L T N T+S
Sbjct: 6105 QVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWY-KDGALLTTGNK--FQTLSEPR 6161
Query: 2528 SGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG--------------VPAAPN 2573
SG + L I +D G+Y C N G+ SA +++Q V A +
Sbjct: 6162 SGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRIQSPMLQAQEQCHREQLVAAVED 6221
Query: 2574 RPIAQ-ERSCTSVILRWLPPSSTGNCT 2599
+ + ++ TSV+ R L P + G T
Sbjct: 6222 TTLERADQEVTSVLKRLLGPKAPGPST 6248
Score = 40.0 bits (92), Expect = 0.035
Identities = 27/101 (26%), Positives = 40/101 (39%), Gaps = 4/101 (3%)
Query: 2467 QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 2526
Q+ P F D +GD + L+C V + W + D + + +
Sbjct: 4894 QQEGPMFSHTFGDTEAQVGDALRLECVVASKADVRARWLKDGVELTDGRH----HHIDQL 4949
Query: 2527 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG 2567
G +L I L D+G YTC +N G + SA V V G
Sbjct: 4950 GDGTCSLLITGLDRADAGCYTCQVSNKFGQVTHSACVVVSG 4990
Score = 39.7 bits (91), Expect = 0.045
Identities = 29/105 (27%), Positives = 51/105 (48%), Gaps = 11/105 (10%)
Query: 2466 IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSS 2525
I+ + F+ L + G T L+C++ + P + W+ +++ D D S +
Sbjct: 3357 IRPMPAHFIGRLRHQESIEGATATLRCEL-SKAAP-VEWRKGRESLRDGDRHSLRQDGAV 3414
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPA 2570
C+ L+IC L D+G Y+C+ G TSAT+ V+ +PA
Sbjct: 3415 CE-----LQICGLAVADAGEYSCVC----GEERTSATLTVKALPA 3450
Score = 38.9 bits (89), Expect = 0.077
Identities = 27/101 (26%), Positives = 42/101 (41%), Gaps = 5/101 (4%)
Query: 2470 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG 2529
AP FL +G L C++ G P P ++W+ Q + + A + ++ D
Sbjct: 9 APRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVA----AGARFRLAQ-DGD 63
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPA 2570
L I +L DSG Y C A N G + ++V A
Sbjct: 64 LYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAA 104
Score = 37.7 bits (86), Expect = 0.17
Identities = 29/105 (27%), Positives = 50/105 (47%), Gaps = 11/105 (10%)
Query: 2466 IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSS 2525
++ + +F L + + G T +L C++ + P KGP+ N+ D D +
Sbjct: 3445 VKALPAKFTEGLRNEEAVEGATAMLWCEL-SKVAPVEWRKGPE-NLRDGDRYILRQEGTR 3502
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPA 2570
C+ L+IC L D+G Y C+ G TSAT+ ++ +PA
Sbjct: 3503 CE-----LQICGLAMADAGEYLCVC----GQERTSATLTIRALPA 3538
Score = 37.4 bits (85), Expect = 0.22
Identities = 40/168 (23%), Positives = 70/168 (41%), Gaps = 21/168 (12%)
Query: 2473 FLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEIT 2532
FL L D++ T+ LQC+V P+ + W+ + +D +T +G
Sbjct: 2649 FLKALDDLSAEERGTLALQCEVSD-PEAHVVWRKDGVQLGPSDKYDFLHT-----AGTRG 2702
Query: 2533 LKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNR-----PIAQERSCT-SVI 2586
L + ++ P+D+G+YTC G+ T A V+V + + + + SC+ +
Sbjct: 2703 LVVHDVSPEDAGLYTCHV----GSEETRARVRVHDLHVGITKRLKTMEVLEGESCSFECV 2758
Query: 2587 LRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSP 2634
L S T+ G TV GS Q+ LV+ + +P
Sbjct: 2759 LSHESASDPAMWTVGGKTV-----GSSSRFQATRQGRKYILVVREAAP 2801
Score = 36.6 bits (83), Expect = 0.38
Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 10/99 (10%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F PL + G T LQC++ P T+ W + N + C + E
Sbjct: 3890 PVFREPLQSLQAEEGSTATLQCEL-SEPTATVVWSKGGLQL--QANGRREPRLQGC-TAE 3945
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVP 2569
+ L+ +L +D+G YTC G+ +TSAT+ V P
Sbjct: 3946 LVLQ--DLQREDTGEYTCTC----GSQATSATLTVTAAP 3978
Score = 35.8 bits (81), Expect = 0.65
Identities = 26/82 (31%), Positives = 38/82 (46%), Gaps = 8/82 (9%)
Query: 2487 TVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIY 2546
+V+L C PK +K DT S + S + L+I LMP D+G+Y
Sbjct: 2485 SVVLSCDFRPAPKAVQWYKD------DTPLSPSEKFKMSLEGQMAELRILRLMPADAGVY 2538
Query: 2547 TCIATNDHGTTSTSATVKVQGV 2568
C A + H +ST TV+ + V
Sbjct: 2539 RCQAGSAH--SSTEVTVEAREV 2558
Score = 35.8 bits (81), Expect = 0.65
Identities = 25/86 (29%), Positives = 43/86 (50%), Gaps = 11/86 (12%)
Query: 2485 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 2544
G T +L+C++ + P WKG + + D D S + C+ L+I L+ +D+G
Sbjct: 3640 GATAVLRCEL-SKMAPVEWWKG-HETLRDGDRHSLRQDGARCE-----LQIRGLVAEDAG 3692
Query: 2545 IYTCIATNDHGTTSTSATVKVQGVPA 2570
Y C+ G TSA + V+ +P+
Sbjct: 3693 EYLCMC----GKERTSAMLTVRAMPS 3714
Score = 35.4 bits (80), Expect = 0.85
Identities = 29/98 (29%), Positives = 42/98 (42%), Gaps = 10/98 (10%)
Query: 2473 FLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEIT 2532
F L D+ L G L+C + P + W + + D S + +
Sbjct: 3187 FQEALKDLEVLEGGAATLRCVLSSVAAP-VKWCYGNNVLRPGDKYSLRQ-----EGAMLE 3240
Query: 2533 LKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPA 2570
L + NL PQDSG Y+C G +TSAT+ V +PA
Sbjct: 3241 LVVRNLRPQDSGRYSC----SFGDQTTSATLTVTALPA 3274
Score = 33.9 bits (76), Expect = 2.5
Identities = 29/103 (28%), Positives = 49/103 (47%), Gaps = 13/103 (12%)
Query: 2491 QCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEI-TLKICNLMPQDSGIYTCI 2549
Q KV G P P + W Q + +A+ + D + TL+I ++ +DSG Y
Sbjct: 5281 QLKVKGYPAPRLYWFKDGQPL------TASAHIRMTDKKILHTLEIISVTREDSGQYAAY 5334
Query: 2550 ATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPP 2592
+N G +SA + V+G P+ P +E+ + V + +PP
Sbjct: 5335 ISNAMGAAYSSARLLVRG----PDEP--EEKPASDVHEQLVPP 5371
>gi|4758194 serine/threonine kinase 17B [Homo sapiens]
Length = 372
Score = 189 bits (481), Expect = 3e-47
Identities = 95/269 (35%), Positives = 163/269 (60%), Gaps = 7/269 (2%)
Query: 2678 ENFDSAYTELN-EIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAA---HEAALLQ 2733
ENF++ Y + E+GRG+F++V++CI K+T ++ A KF+ K+ + ++ A HE A+L+
Sbjct: 26 ENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLE 85
Query: 2734 HLQH-PQYITLHDTYESPTSYILILELMDDGRLLDYLMNH--DELMEEKVAFYIRDIMEA 2790
+ P+ I LH+ YE+ + ILILE G + + + + E V I+ I+E
Sbjct: 86 LAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEG 145
Query: 2791 LQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPE 2850
+ YLH + HLD+KP+N+L+ P+ +K++D + +I + ++G PE+ APE
Sbjct: 146 VYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPE 205
Query: 2851 VIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNA 2910
++ P++ TD+W+IG++ Y++L+ SPF+ E +ET +N+ +V+ + E F VS
Sbjct: 206 ILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQL 265
Query: 2911 ARDFINVILQEDFRRRPTAATCLQHPWLQ 2939
A DFI +L ++ +RPTA CL H WLQ
Sbjct: 266 ATDFIQSLLVKNPEKRPTAEICLSHSWLQ 294
>gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]
Length = 1863
Score = 185 bits (469), Expect = 7e-46
Identities = 156/588 (26%), Positives = 244/588 (41%), Gaps = 98/588 (16%)
Query: 2415 ENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFL 2474
ENT E R+PK L + + + ++ P +M P IQ PE
Sbjct: 1194 ENTKAPEMKS-RRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMP---PQIIQ--FPE-- 1245
Query: 2475 VPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLK 2534
D G++V L KV G T TW + I ++++ V + ++G L
Sbjct: 1246 ----DQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMK----VENSENGS-KLT 1296
Query: 2535 ICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAP-NRPIAQERSCTSVILRWLPPS 2593
I + G YT + N G+ + V P P P A + +S+ L W S
Sbjct: 1297 ILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSS 1356
Query: 2594 STGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP 2653
G + Y++E + ++ W++ +A+ T ++DL P Y+FRV A N +G S P
Sbjct: 1357 YDGGSAVQSYSIEIWDSANKTWKE-LATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEP 1415
Query: 2654 SEPSEFVRL--------------------PEYDAAADGATISWKENFDSAYTELNEIGRG 2693
S+ SE + PE D TI+ ++ Y +G G
Sbjct: 1416 SQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRT--VTINTEQKVSDFYDIEERLGSG 1473
Query: 2694 RFSIVKKCIHKATRKDVAVKFVSK-KMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTS 2752
+F V + + K TRK A KF K+KE E +++ L HP+ + D +E +
Sbjct: 1474 KFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKAN 1533
Query: 2753 YILILELMDDGRLLDYLMNHD-ELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLI 2811
+++LE++ G L + +++ D EL E + Y+R I E ++Y+H + HLD+KPEN++
Sbjct: 1534 IVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMC 1593
Query: 2812 DLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTY 2871
+ R+KLID A ++ + L G PEF APEVI P+ TD+WSIGV+ Y
Sbjct: 1594 VNKTGT-RIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICY 1652
Query: 2872 VMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAAT 2931
++ R
Sbjct: 1653 IL---------------------------------------------------NRLDCTQ 1661
Query: 2932 CLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQ---NDVRPIPNVKS 2976
CLQHPWL + L R+ ++ RRK Q N VR I + S
Sbjct: 1662 CLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSS 1709
Score = 71.2 bits (173), Expect = 1e-11
Identities = 45/122 (36%), Positives = 58/122 (47%), Gaps = 18/122 (14%)
Query: 2466 IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSS 2525
+ EVAP F L D + G +LQC V G P P ITW Q I Y S+
Sbjct: 509 VMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI--------QYARST 560
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG----------VPAAPNRP 2575
C++G L I + +P+D G YTC+A N G S SA V V +P AP++P
Sbjct: 561 CEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKP 620
Query: 2576 IA 2577
A
Sbjct: 621 TA 622
Score = 60.1 bits (144), Expect = 3e-08
Identities = 40/126 (31%), Positives = 60/126 (47%), Gaps = 6/126 (4%)
Query: 2463 PNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYT 2522
P+ E P+F L V G CK+ GRP+P +TW + + SA +
Sbjct: 153 PSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPL----QPSARVS 208
Query: 2523 VSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSC 2582
VS +G L+I + D G+YTC+ N G S SA + +QG+ +A NR +E
Sbjct: 209 VSE-KNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSA-NRSFVRETKA 266
Query: 2583 TSVILR 2588
T+ +R
Sbjct: 267 TNSDVR 272
Score = 58.9 bits (141), Expect = 7e-08
Identities = 58/241 (24%), Positives = 89/241 (36%), Gaps = 37/241 (15%)
Query: 2343 SQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAAESSD--GSIKKS 2400
S E + AV QP+ P P L P+ A AE+ G+ K
Sbjct: 998 SSAETLNAKAVESSKPLSNAQPSGPLKPVGNA-KPAETLKPMGNAKPAETLKPMGNAKPD 1056
Query: 2401 CSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEI 2460
L+ + E++ KN D+ + T++ + SE
Sbjct: 1057 ---ENLKSASKEELKKDVKN---------DVNCKRGHAGTTDNEKRSES----------- 1093
Query: 2461 LNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSAT 2520
Q AP F L DV G ++LQC+V P TI W + + T
Sbjct: 1094 ------QGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK----- 1142
Query: 2521 YTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER 2580
+ + S + ++ I +P+D G+Y C+A ND G S V V PA+ N + +
Sbjct: 1143 FIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMK 1202
Query: 2581 S 2581
S
Sbjct: 1203 S 1203
Score = 50.1 bits (118), Expect = 3e-05
Identities = 59/224 (26%), Positives = 96/224 (42%), Gaps = 30/224 (13%)
Query: 2436 VSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVC 2495
V+V E SS +SE +L + AP FL L D+ + G V + +V
Sbjct: 598 VTVHEKKSSRKSEY----------LLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVS 647
Query: 2496 GRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHG 2555
G P P + W I ++++ + + +L I + P+D+G YTC A N G
Sbjct: 648 GNPPPEVIWLHNGNEIQESEDFHFEQRGT-----QHSLCIQEVFPEDTGTYTCEAWNSAG 702
Query: 2556 TTSTSATVKVQGVPAAPNRP--IAQERSCTSVILRWLPPSSTGNCTISG---YTVEYREE 2610
T A + VQ P +P I++ RS T+ L S +C I+G TV + +
Sbjct: 703 EVRTQAVLTVQ-EPHDGTQPWFISKPRSVTAS----LGQSVLISCAIAGDPFPTVHWLRD 757
Query: 2611 GSQIWQQS----VASTLDTY-LVIEDLSPGCPYQFRVSASNPWG 2649
G + + + V D + LV++ + P Q+ + N G
Sbjct: 758 GKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVG 801
Score = 45.8 bits (107), Expect = 6e-04
Identities = 29/98 (29%), Positives = 45/98 (45%), Gaps = 4/98 (4%)
Query: 2470 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG 2529
AP F++P ++ G T + +V G P+P +TW Q I S + + G
Sbjct: 32 APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPI----TSGGRFLLDCGIRG 87
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG 2567
+L I + +D G YTC ATN G + + V+G
Sbjct: 88 TFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEG 125
Score = 45.4 bits (106), Expect = 8e-04
Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 4/98 (4%)
Query: 2469 VAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDS 2528
V P F + D+ + G CK+ G P P + W DQ+I ++ + Y +
Sbjct: 1756 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYD----ED 1811
Query: 2529 GEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
G +L I ++ D YTC A N G + +A + V+
Sbjct: 1812 GNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 1849
Score = 44.7 bits (104), Expect = 0.001
Identities = 26/80 (32%), Positives = 39/80 (48%), Gaps = 4/80 (5%)
Query: 2487 TVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIY 2546
TV +C+V G PKP + W + + S Y D+G L + +DSG Y
Sbjct: 430 TVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYE----DAGSHYLCLLKARTRDSGTY 485
Query: 2547 TCIATNDHGTTSTSATVKVQ 2566
+C A+N G S S T++V+
Sbjct: 486 SCTASNAQGQLSCSWTLQVE 505
Score = 35.0 bits (79), Expect = 1.1
Identities = 25/101 (24%), Positives = 42/101 (41%), Gaps = 6/101 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNIL-DTDNSSATYTVSSCDSG 2529
P F+ VT LG +V++ C + G P PT+ W + + DT + +
Sbjct: 721 PWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQ-----NED 775
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPA 2570
TL + + P +G Y + N G S ++ +Q A
Sbjct: 776 VFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSA 816
>gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens]
Length = 1794
Score = 185 bits (469), Expect = 7e-46
Identities = 156/588 (26%), Positives = 244/588 (41%), Gaps = 98/588 (16%)
Query: 2415 ENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFL 2474
ENT E R+PK L + + + ++ P +M P IQ PE
Sbjct: 1125 ENTKAPEMKS-RRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMP---PQIIQ--FPE-- 1176
Query: 2475 VPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLK 2534
D G++V L KV G T TW + I ++++ V + ++G L
Sbjct: 1177 ----DQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMK----VENSENGS-KLT 1227
Query: 2535 ICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAP-NRPIAQERSCTSVILRWLPPS 2593
I + G YT + N G+ + V P P P A + +S+ L W S
Sbjct: 1228 ILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSS 1287
Query: 2594 STGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLP 2653
G + Y++E + ++ W++ +A+ T ++DL P Y+FRV A N +G S P
Sbjct: 1288 YDGGSAVQSYSIEIWDSANKTWKE-LATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEP 1346
Query: 2654 SEPSEFVRL--------------------PEYDAAADGATISWKENFDSAYTELNEIGRG 2693
S+ SE + PE D TI+ ++ Y +G G
Sbjct: 1347 SQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRT--VTINTEQKVSDFYDIEERLGSG 1404
Query: 2694 RFSIVKKCIHKATRKDVAVKFVSK-KMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTS 2752
+F V + + K TRK A KF K+KE E +++ L HP+ + D +E +
Sbjct: 1405 KFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKAN 1464
Query: 2753 YILILELMDDGRLLDYLMNHD-ELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLI 2811
+++LE++ G L + +++ D EL E + Y+R I E ++Y+H + HLD+KPEN++
Sbjct: 1465 IVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMC 1524
Query: 2812 DLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTY 2871
+ R+KLID A ++ + L G PEF APEVI P+ TD+WSIGV+ Y
Sbjct: 1525 VNKTGT-RIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICY 1583
Query: 2872 VMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAAT 2931
++ R
Sbjct: 1584 IL---------------------------------------------------NRLDCTQ 1592
Query: 2932 CLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQ---NDVRPIPNVKS 2976
CLQHPWL + L R+ ++ RRK Q N VR I + S
Sbjct: 1593 CLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSS 1640
Score = 71.2 bits (173), Expect = 1e-11
Identities = 45/122 (36%), Positives = 58/122 (47%), Gaps = 18/122 (14%)
Query: 2466 IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSS 2525
+ EVAP F L D + G +LQC V G P P ITW Q I Y S+
Sbjct: 440 VMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI--------QYARST 491
Query: 2526 CDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG----------VPAAPNRP 2575
C++G L I + +P+D G YTC+A N G S SA V V +P AP++P
Sbjct: 492 CEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKP 551
Query: 2576 IA 2577
A
Sbjct: 552 TA 553
Score = 60.1 bits (144), Expect = 3e-08
Identities = 40/126 (31%), Positives = 60/126 (47%), Gaps = 6/126 (4%)
Query: 2463 PNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYT 2522
P+ E P+F L V G CK+ GRP+P +TW + + SA +
Sbjct: 153 PSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPL----QPSARVS 208
Query: 2523 VSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSC 2582
VS +G L+I + D G+YTC+ N G S SA + +QG+ +A NR +E
Sbjct: 209 VSE-KNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSA-NRSFVRETKA 266
Query: 2583 TSVILR 2588
T+ +R
Sbjct: 267 TNSDVR 272
Score = 58.9 bits (141), Expect = 7e-08
Identities = 58/241 (24%), Positives = 89/241 (36%), Gaps = 37/241 (15%)
Query: 2343 SQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAAESSD--GSIKKS 2400
S E + AV QP+ P P L P+ A AE+ G+ K
Sbjct: 929 SSAETLNAKAVESSKPLSNAQPSGPLKPVGNA-KPAETLKPMGNAKPAETLKPMGNAKPD 987
Query: 2401 CSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEI 2460
L+ + E++ KN D+ + T++ + SE
Sbjct: 988 ---ENLKSASKEELKKDVKN---------DVNCKRGHAGTTDNEKRSES----------- 1024
Query: 2461 LNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSAT 2520
Q AP F L DV G ++LQC+V P TI W + + T
Sbjct: 1025 ------QGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK----- 1073
Query: 2521 YTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER 2580
+ + S + ++ I +P+D G+Y C+A ND G S V V PA+ N + +
Sbjct: 1074 FIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMK 1133
Query: 2581 S 2581
S
Sbjct: 1134 S 1134
Score = 50.1 bits (118), Expect = 3e-05
Identities = 59/224 (26%), Positives = 96/224 (42%), Gaps = 30/224 (13%)
Query: 2436 VSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVC 2495
V+V E SS +SE +L + AP FL L D+ + G V + +V
Sbjct: 529 VTVHEKKSSRKSEY----------LLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVS 578
Query: 2496 GRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHG 2555
G P P + W I ++++ + + +L I + P+D+G YTC A N G
Sbjct: 579 GNPPPEVIWLHNGNEIQESEDFHFEQRGT-----QHSLCIQEVFPEDTGTYTCEAWNSAG 633
Query: 2556 TTSTSATVKVQGVPAAPNRP--IAQERSCTSVILRWLPPSSTGNCTISG---YTVEYREE 2610
T A + VQ P +P I++ RS T+ L S +C I+G TV + +
Sbjct: 634 EVRTQAVLTVQ-EPHDGTQPWFISKPRSVTAS----LGQSVLISCAIAGDPFPTVHWLRD 688
Query: 2611 GSQIWQQS----VASTLDTY-LVIEDLSPGCPYQFRVSASNPWG 2649
G + + + V D + LV++ + P Q+ + N G
Sbjct: 689 GKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVG 732
Score = 45.8 bits (107), Expect = 6e-04
Identities = 29/98 (29%), Positives = 45/98 (45%), Gaps = 4/98 (4%)
Query: 2470 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG 2529
AP F++P ++ G T + +V G P+P +TW Q I S + + G
Sbjct: 32 APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPI----TSGGRFLLDCGIRG 87
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQG 2567
+L I + +D G YTC ATN G + + V+G
Sbjct: 88 TFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEG 125
Score = 45.4 bits (106), Expect = 8e-04
Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 4/98 (4%)
Query: 2469 VAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDS 2528
V P F + D+ + G CK+ G P P + W DQ+I ++ + Y +
Sbjct: 1687 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYD----ED 1742
Query: 2529 GEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 2566
G +L I ++ D YTC A N G + +A + V+
Sbjct: 1743 GNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 1780
Score = 35.0 bits (79), Expect = 1.1
Identities = 25/101 (24%), Positives = 42/101 (41%), Gaps = 6/101 (5%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNIL-DTDNSSATYTVSSCDSG 2529
P F+ VT LG +V++ C + G P PT+ W + + DT + +
Sbjct: 652 PWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQ-----NED 706
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPA 2570
TL + + P +G Y + N G S ++ +Q A
Sbjct: 707 VFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSA 747
>gi|157785645 SPEG complex locus [Homo sapiens]
Length = 3267
Score = 184 bits (466), Expect = 1e-45
Identities = 150/577 (25%), Positives = 252/577 (43%), Gaps = 50/577 (8%)
Query: 2422 ATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVT 2481
ATG RK + +S +SS+ S P+ +++L E AP L D+
Sbjct: 1346 ATGLRKGVQHIFRVLSTTVKSSSKPSP-----PSEPVQLLEHGPTLEEAPAML-DKPDIV 1399
Query: 2482 CLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQ 2541
++ + + W+ +L+ + Y +S D + L+IC + +
Sbjct: 1400 YVVEGQPASVTVTFNHVEAQVVWRSCRGALLEA--RAGVYELSQPDDDQYCLRICRVSRR 1457
Query: 2542 DSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTIS 2601
D G TC A N HGT + +V ++ A I ++ G
Sbjct: 1458 DMGALTCTARNRHGTQT--CSVTLELAEAPRFESIMEDVEV-----------GAGETARF 1504
Query: 2602 GYTVEYREEGSQIW-QQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI------SLPS 2654
VE + +W + V T +++ C + + G+ +L
Sbjct: 1505 AVVVEGKPLPDIMWYKDEVLLTESSHVSFVYEENECSLVVLSTGAQDGGVYTCTAQNLAG 1564
Query: 2655 EPSEFVRLPEYDAAADGATISWKENFDSAYTELN-------EIGRGRFSIVKKCIHKATR 2707
E S L + A E+ D L+ EIGRG FS +++ + +++
Sbjct: 1565 EVSCKAELAVHSAQTAMEVEGVGEDEDHRGRRLSDFYDIHQEIGRGAFSYLRRIVERSSG 1624
Query: 2708 KDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLD 2767
+ A KF+ + K K A EA LL LQH + H+ +E +++ EL + LL+
Sbjct: 1625 LEFAAKFIPSQAKPKASARREARLLARLQHDCVLYFHEAFERRRGLVIVTELCTE-ELLE 1683
Query: 2768 YLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLI-DLRIPVPRVKLIDLE 2826
+ + E ++ Y+R ++E + YLH V HLD+KPENLL+ D +V++ D
Sbjct: 1684 RIARKPTVCESEIRAYMRQVLEGIHYLHQSHVLHLDVKPENLLVWDGAAGEQQVRICDFG 1743
Query: 2827 DAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKE 2886
+A +++ + G PEF APE++ PVS TDIW +GV+ ++ L+G+SPF+ E+
Sbjct: 1744 NAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISPFVGENDR 1803
Query: 2887 ETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQPHNGSYS 2946
T +N+ + +F F +S AR F+ +L +D R RPTA L+HPW +
Sbjct: 1804 TTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD-RLRPTAEETLEHPWFKT---QAK 1859
Query: 2947 KIPLDTSRLACFIERRKHQND---------VRPIPNV 2974
+ T L F+ RR+ Q +RPIP +
Sbjct: 1860 GAEVSTDHLKLFLSRRRWQRSQISYKCHLVLRPIPEL 1896
Score = 155 bits (393), Expect = 4e-37
Identities = 92/258 (35%), Positives = 133/258 (51%), Gaps = 6/258 (2%)
Query: 2684 YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITL 2743
YT L E RGRF +V+ C AT + K V + K + E +L+ L H + ++L
Sbjct: 2966 YTFLEEKARGRFGVVRACRENATGRTFVAKIVPYAAEGKRRVLQEYEVLRTLHHERIMSL 3025
Query: 2744 HDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLD 2803
H+ Y +P +LI E + LL L + E+ VA Y+ +++ L YLH V HLD
Sbjct: 3026 HEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYMVQLLQGLDYLHGHHVLHLD 3085
Query: 2804 IKPENLLIDLRIPVPRVKLIDLEDAVQISGHF--HIHHLLGNPEFAAPEVIQGIPVSLGT 2861
IKP+NLL+ P +K++D A + + H G EF APE+++G P+ T
Sbjct: 3086 IKPDNLLL---APDNALKIVDFGSAQPYNPQALRPLGHRTGTLEFMAPEMVKGEPIGSAT 3142
Query: 2862 DIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQE 2921
DIW GVLTY+MLSG SPF + +ET + F + + S +A F+ +L
Sbjct: 3143 DIWGAGVLTYIMLSGRSPFYEPDPQETEARIVGGRFD-AFQLYPNTSQSATLFLRKVLSV 3201
Query: 2922 DFRRRPTAATCLQHPWLQ 2939
RP+ CL HPWLQ
Sbjct: 3202 HPWSRPSLQDCLAHPWLQ 3219
Score = 82.4 bits (202), Expect = 6e-15
Identities = 60/204 (29%), Positives = 88/204 (43%), Gaps = 9/204 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P F + L D L G+ L C P P I+W +++ S + + SC G
Sbjct: 2584 PVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSL----RSEPSVIIVSCKDGR 2639
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWL 2590
L I + +G+Y C ATN G+ ++S TV V VP P + + ++ W
Sbjct: 2640 QLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARVPGKLAPPEVPQTYQDTALVLWK 2699
Query: 2591 PPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGI 2650
P S CT YT+E R +G +W + D Y + L G +FRV+ +N G
Sbjct: 2700 PGDSRAPCT---YTLERRVDGESVWHPVSSGIPDCYYNVTHLPVGVTVRFRVACANRAGQ 2756
Query: 2651 SLPSEPSE--FVRLPEYDAAADGA 2672
S SE FVR + +A A
Sbjct: 2757 GPFSNSSEKVFVRGTQDSSAVPSA 2780
Score = 69.3 bits (168), Expect = 5e-11
Identities = 60/207 (28%), Positives = 85/207 (41%), Gaps = 10/207 (4%)
Query: 2471 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 2530
P+FL PL D+ L +L+C+V G P PTI+W I +D+ T D
Sbjct: 1188 PDFLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMT---QYRDVHR 1244
Query: 2531 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTS--VILR 2588
+ PQ +G+Y + N G + A + V V P Q + T V L
Sbjct: 1245 LVFPAVG--PQHAGVYKSVIANKLGKAACYAHLYVTDVVPGPPDGAPQVVAVTGRMVTLT 1302
Query: 2589 WLPPSSTGNCTISG---YTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSAS 2645
W PP S YTV+++ GS W V + L G + FRV ++
Sbjct: 1303 WNPPRSLDMAIDPDSLTYTVQHQVLGSDQWTALVTGLREPGWAATGLRKGVQHIFRVLST 1362
Query: 2646 NPWGISLPSEPSEFVRLPEYDAAADGA 2672
S PS PSE V+L E+ + A
Sbjct: 1363 TVKSSSKPSPPSEPVQLLEHGPTLEEA 1389
Score = 51.6 bits (122), Expect = 1e-05
Identities = 32/118 (27%), Positives = 52/118 (44%), Gaps = 4/118 (3%)
Query: 2452 LDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNI 2511
+ P+ S + + + P F V L+D + G VI+ +V G PKP ++W Q +
Sbjct: 850 MKPSPSQNRRSSDTGSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPV 909
Query: 2512 LDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVP 2569
A + G L+I D+G YTC A N++G A ++V+ P
Sbjct: 910 RPDQRRFA----EEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHP 963
Score = 49.3 bits (116), Expect = 6e-05
Identities = 33/117 (28%), Positives = 51/117 (43%), Gaps = 5/117 (4%)
Query: 2469 VAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDS 2528
+AP F L DV L G CK+ G P P +TW + +++N D
Sbjct: 1062 LAPLFTRLLEDVEVLEGRAARFDCKISGTPPPVVTWTHFGCPMEESENLRLRQ-----DG 1116
Query: 2529 GEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSV 2585
G +L I ++ +D G+Y A N HG SA + V+ A + P ++ S+
Sbjct: 1117 GLHSLHIAHVGSEDEGLYAVSAVNTHGQAHCSAQLYVEEPRTAASGPSSKLEKMPSI 1173
Score = 45.1 bits (105), Expect = 0.001
Identities = 31/96 (32%), Positives = 44/96 (45%), Gaps = 12/96 (12%)
Query: 2470 APEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSG 2529
AP FL PL + G V L+ V G P+P++ W D A SC
Sbjct: 42 APVFLRPLKNAAVCAGSDVRLRVVVSGTPQPSLRW------FRDGQLLPAPAPEPSC--- 92
Query: 2530 EITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV 2565
+ L+ C QD+G+Y+C+A N+ G S A + V
Sbjct: 93 -LWLRRCG--AQDAGVYSCMAQNERGRASCEAVLTV 125
Score = 43.9 bits (102), Expect = 0.002
Identities = 47/181 (25%), Positives = 70/181 (38%), Gaps = 18/181 (9%)
Query: 2421 EATGPRKPKDILGNKVSVK----ETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVP 2476
E GP P D G + K S E DD + E L AP F +P
Sbjct: 675 EEDGPWGPWDRRGARSQGKGRRARPTSPELESSDDSYVSAGEEPLE-------APVFEIP 727
Query: 2477 LVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKIC 2536
L +V G V+L+C + P P ++W D + L ++ + + TL +
Sbjct: 728 LQNVVVAPGADVLLKCIITANPPPQVSWH-KDGSALRSEGR----LLLRAEGERHTLLLR 782
Query: 2537 NLMPQDSGIYTCIATNDHG--TTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSS 2594
D+G Y ATN+ G T + S TV+ G + + PI + S + P
Sbjct: 783 EARAADAGSYMATATNELGQATCAASLTVRPGGSTSPFSSPITSDEEYLSPPEEFPEPGE 842
Query: 2595 T 2595
T
Sbjct: 843 T 843
>gi|193211603 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 2 [Homo sapiens]
Length = 1110
Score = 182 bits (461), Expect = 6e-45
Identities = 109/323 (33%), Positives = 179/323 (55%), Gaps = 12/323 (3%)
Query: 1910 APPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMR 1969
A PT P P ++L VL E+V TE++YV+ L +E + ++ VP+ +R
Sbjct: 634 ASPTVP--PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLR 691
Query: 1970 GKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSE 2029
G+ +FGN+ ++ D+H FFL ELE C + R+A F++H + +Y Y +NKPRS+
Sbjct: 692 GQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSD 751
Query: 2030 YIVAEY-DAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIE 2088
+++ Y +F++ +Q + L L+ +L+KPIQR+ KY LLL++ R E S +
Sbjct: 752 ALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALR 811
Query: 2089 KAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKE-RRV 2147
+A L+ + ND++ + +QG + L QG+L++QD F V R K RR+
Sbjct: 812 EAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVV------RTGRHKSVRRI 865
Query: 2148 FLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFAL--MNRETSERVV 2205
FLFE++++FS+ + + +KRS KM L L E N +F + R+ + V
Sbjct: 866 FLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFV 925
Query: 2206 LQAANADIQQAWVQDINQVLETQ 2228
LQA++ I+QAW DI+ +L Q
Sbjct: 926 LQASSLAIKQAWTADISHLLWRQ 948
Score = 178 bits (451), Expect = 8e-44
Identities = 108/317 (34%), Positives = 170/317 (53%), Gaps = 16/317 (5%)
Query: 1277 KSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEI 1336
+S + + ++AE++ TE+ YVR L +E Y E+ ++P G+ + +FGN++++
Sbjct: 647 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 704
Query: 1337 YDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDE 1396
DFH + FL+ELE + P V + F+ +F MY Y KNKP S+ L+ + TFF +
Sbjct: 705 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 764
Query: 1397 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVP---KKA 1453
QQ G ++SYL+KP+QR+ KY LLL+EL C EL E V +
Sbjct: 765 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 824
Query: 1454 NDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRE---RHLFLFEISLVFSKE 1510
ND + + ++G D NL QG+L+ QD F ++R GR R +FLFE L+FSK
Sbjct: 825 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 877
Query: 1511 IKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQE 1570
+G + YK ++LG+TE +F +W R + D VL+AS++ KQ
Sbjct: 878 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 936
Query: 1571 WIKNIREVIQERIIHLK 1587
W +I ++ + +H K
Sbjct: 937 WTADISHLLWRQAVHNK 953
Score = 52.4 bits (124), Expect = 7e-06
Identities = 62/288 (21%), Positives = 117/288 (40%), Gaps = 32/288 (11%)
Query: 39 LKEKVAFVSGGRDKRGGPILTFPARSN---HDRIRQEDLRKLVTYLASVPSEDVCKRGFT 95
+ ++ G RD +G +L A S ++L +L+ YL S+P +V G T
Sbjct: 109 MSSHLSLAQGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLT 168
Query: 96 VIIDMR-GSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMV 154
V++D R + + L LQEA P ++ L++ T + +
Sbjct: 169 VLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVG--------STLLKEVPSGLQLEQL 220
Query: 155 SVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARK 214
+ L + + L G L Y H+ W++ R LE + + L+ E +
Sbjct: 221 PSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAV 280
Query: 215 EFPVDVEGSRRLIDEHTQLKKKVLKAP-VEELDREGQRLLQCIRCSDGFSGRNCIPG--- 270
P++ +L+ + L ++VL +P + L +G R L ++ +P
Sbjct: 281 PQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQE--------VPEVTL 332
Query: 271 SADFQSLVPKITSLLDKLHSTRQHLHQM-----WHVRKLKLDQCFQLR 313
S D+++ + K L D++ LHQ+ ++ L+L Q + R
Sbjct: 333 SPDYRTAMDKADELYDRVDGL---LHQLTLQSNQRIQALELVQTLEAR 377
>gi|193211598 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 182 bits (461), Expect = 6e-45
Identities = 109/323 (33%), Positives = 179/323 (55%), Gaps = 12/323 (3%)
Query: 1910 APPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMR 1969
A PT P P ++L VL E+V TE++YV+ L +E + ++ VP+ +R
Sbjct: 715 ASPTVP--PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLR 772
Query: 1970 GKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSE 2029
G+ +FGN+ ++ D+H FFL ELE C + R+A F++H + +Y Y +NKPRS+
Sbjct: 773 GQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSD 832
Query: 2030 YIVAEY-DAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIE 2088
+++ Y +F++ +Q + L L+ +L+KPIQR+ KY LLL++ R E S +
Sbjct: 833 ALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALR 892
Query: 2089 KAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKE-RRV 2147
+A L+ + ND++ + +QG + L QG+L++QD F V R K RR+
Sbjct: 893 EAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVV------RTGRHKSVRRI 946
Query: 2148 FLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFAL--MNRETSERVV 2205
FLFE++++FS+ + + +KRS KM L L E N +F + R+ + V
Sbjct: 947 FLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFV 1006
Query: 2206 LQAANADIQQAWVQDINQVLETQ 2228
LQA++ I+QAW DI+ +L Q
Sbjct: 1007 LQASSLAIKQAWTADISHLLWRQ 1029
Score = 178 bits (451), Expect = 8e-44
Identities = 108/317 (34%), Positives = 170/317 (53%), Gaps = 16/317 (5%)
Query: 1277 KSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEI 1336
+S + + ++AE++ TE+ YVR L +E Y E+ ++P G+ + +FGN++++
Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 785
Query: 1337 YDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDE 1396
DFH + FL+ELE + P V + F+ +F MY Y KNKP S+ L+ + TFF +
Sbjct: 786 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 845
Query: 1397 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVP---KKA 1453
QQ G ++SYL+KP+QR+ KY LLL+EL C EL E V +
Sbjct: 846 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 905
Query: 1454 NDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRE---RHLFLFEISLVFSKE 1510
ND + + ++G D NL QG+L+ QD F ++R GR R +FLFE L+FSK
Sbjct: 906 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 958
Query: 1511 IKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQE 1570
+G + YK ++LG+TE +F +W R + D VL+AS++ KQ
Sbjct: 959 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 1017
Query: 1571 WIKNIREVIQERIIHLK 1587
W +I ++ + +H K
Sbjct: 1018 WTADISHLLWRQAVHNK 1034
Score = 54.3 bits (129), Expect = 2e-06
Identities = 68/300 (22%), Positives = 124/300 (41%), Gaps = 33/300 (11%)
Query: 28 DGLKASDVL-PILKEKVAFVSGGRDKRGGPILTFPARSN---HDRIRQEDLRKLVTYLAS 83
D L A D+ +L +A + G RD +G +L A S ++L +L+ YL S
Sbjct: 178 DCLLAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRS 237
Query: 84 VPSEDVCKRGFTVIIDMR-GSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNF 142
+P +V G TV++D R + + L LQEA P ++ L++ T
Sbjct: 238 IPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVG--------STLL 289
Query: 143 GSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLS 202
+ + + L + + L G L Y H+ W++ R LE + +
Sbjct: 290 KEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACA 349
Query: 203 RLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAP-VEELDREGQRLLQCIRCSDG 261
L+ E + P++ +L+ + L ++VL +P + L +G R L ++
Sbjct: 350 LLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQE-- 407
Query: 262 FSGRNCIPG---SADFQSLVPKITSLLDKLHSTRQHLHQM-----WHVRKLKLDQCFQLR 313
+P S D+++ + K L D++ LHQ+ ++ L+L Q + R
Sbjct: 408 ------VPEVTLSPDYRTAMDKADELYDRVDGL---LHQLTLQSNQRIQALELVQTLEAR 458
>gi|193211596 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 182 bits (461), Expect = 6e-45
Identities = 109/323 (33%), Positives = 179/323 (55%), Gaps = 12/323 (3%)
Query: 1910 APPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMR 1969
A PT P P ++L VL E+V TE++YV+ L +E + ++ VP+ +R
Sbjct: 715 ASPTVP--PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLR 772
Query: 1970 GKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSE 2029
G+ +FGN+ ++ D+H FFL ELE C + R+A F++H + +Y Y +NKPRS+
Sbjct: 773 GQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSD 832
Query: 2030 YIVAEY-DAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIE 2088
+++ Y +F++ +Q + L L+ +L+KPIQR+ KY LLL++ R E S +
Sbjct: 833 ALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALR 892
Query: 2089 KAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKE-RRV 2147
+A L+ + ND++ + +QG + L QG+L++QD F V R K RR+
Sbjct: 893 EAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVV------RTGRHKSVRRI 946
Query: 2148 FLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFAL--MNRETSERVV 2205
FLFE++++FS+ + + +KRS KM L L E N +F + R+ + V
Sbjct: 947 FLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFV 1006
Query: 2206 LQAANADIQQAWVQDINQVLETQ 2228
LQA++ I+QAW DI+ +L Q
Sbjct: 1007 LQASSLAIKQAWTADISHLLWRQ 1029
Score = 178 bits (451), Expect = 8e-44
Identities = 108/317 (34%), Positives = 170/317 (53%), Gaps = 16/317 (5%)
Query: 1277 KSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEI 1336
+S + + ++AE++ TE+ YVR L +E Y E+ ++P G+ + +FGN++++
Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDR--PDVPQGLRGQRAHLFGNLEKL 785
Query: 1337 YDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDE 1396
DFH + FL+ELE + P V + F+ +F MY Y KNKP S+ L+ + TFF +
Sbjct: 786 RDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKD 845
Query: 1397 IQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVP---KKA 1453
QQ G ++SYL+KP+QR+ KY LLL+EL C EL E V +
Sbjct: 846 KQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHG 905
Query: 1454 NDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRE---RHLFLFEISLVFSKE 1510
ND + + ++G D NL QG+L+ QD F ++R GR R +FLFE L+FSK
Sbjct: 906 NDLLAMDAIQGCDVNLKEQGQLVRQDEF-------VVRTGRHKSVRRIFLFEELLLFSKP 958
Query: 1511 IKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQE 1570
+G + YK ++LG+TE +F +W R + D VL+AS++ KQ
Sbjct: 959 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDT-FVLQASSLAIKQA 1017
Query: 1571 WIKNIREVIQERIIHLK 1587
W +I ++ + +H K
Sbjct: 1018 WTADISHLLWRQAVHNK 1034
Score = 54.3 bits (129), Expect = 2e-06
Identities = 68/300 (22%), Positives = 124/300 (41%), Gaps = 33/300 (11%)
Query: 28 DGLKASDVL-PILKEKVAFVSGGRDKRGGPILTFPARSN---HDRIRQEDLRKLVTYLAS 83
D L A D+ +L +A + G RD +G +L A S ++L +L+ YL S
Sbjct: 178 DCLLAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRS 237
Query: 84 VPSEDVCKRGFTVIIDMR-GSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNF 142
+P +V G TV++D R + + L LQEA P ++ L++ T
Sbjct: 238 IPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVG--------STLL 289
Query: 143 GSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLS 202
+ + + L + + L G L Y H+ W++ R LE + +
Sbjct: 290 KEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACA 349
Query: 203 RLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAP-VEELDREGQRLLQCIRCSDG 261
L+ E + P++ +L+ + L ++VL +P + L +G R L ++
Sbjct: 350 LLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQE-- 407
Query: 262 FSGRNCIPG---SADFQSLVPKITSLLDKLHSTRQHLHQM-----WHVRKLKLDQCFQLR 313
+P S D+++ + K L D++ LHQ+ ++ L+L Q + R
Sbjct: 408 ------VPEVTLSPDYRTAMDKADELYDRVDGL---LHQLTLQSNQRIQALELVQTLEAR 458
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 115,068,761
Number of Sequences: 37866
Number of extensions: 5419115
Number of successful extensions: 29282
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 701
Number of HSP's successfully gapped in prelim test: 809
Number of HSP's that attempted gapping in prelim test: 20059
Number of HSP's gapped (non-prelim): 6591
length of query: 2986
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2866
effective length of database: 13,703,598
effective search space: 39274511868
effective search space used: 39274511868
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.