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Search of human proteins with 148612818
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148612818 protein kinase, cGMP-dependent, type I isoform 1
[Homo sapiens]
(671 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H... 1357 0.0
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho... 1213 0.0
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens] 670 0.0
gi|4826948 protein kinase, X-linked [Homo sapiens] 292 6e-79
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 280 4e-75
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 280 4e-75
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 278 2e-74
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 278 2e-74
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 269 5e-72
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 238 1e-62
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 233 3e-61
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 227 2e-59
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 227 3e-59
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 227 3e-59
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 224 2e-58
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 224 2e-58
gi|46909587 cAMP-dependent protein kinase catalytic subunit beta... 222 1e-57
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 221 1e-57
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 217 3e-56
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 217 3e-56
gi|5453974 protein kinase N2 [Homo sapiens] 215 1e-55
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 214 2e-55
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 214 2e-55
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 214 2e-55
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 214 2e-55
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 214 2e-55
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 214 2e-55
gi|4502023 AKT2 kinase [Homo sapiens] 214 3e-55
gi|62241015 AKT1 kinase [Homo sapiens] 210 4e-54
gi|62241013 AKT1 kinase [Homo sapiens] 210 4e-54
>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
sapiens]
Length = 671
Score = 1357 bits (3511), Expect = 0.0
Identities = 671/671 (100%), Positives = 671/671 (100%)
Query: 1 MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTR 60
MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTR
Sbjct: 1 MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTR 60
Query: 61 AQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMY 120
AQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMY
Sbjct: 61 AQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMY 120
Query: 121 PVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTAT 180
PVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTAT
Sbjct: 121 PVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTAT 180
Query: 181 VKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEET 240
VKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEET
Sbjct: 181 VKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEET 240
Query: 241 HYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDV 300
HYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDV
Sbjct: 241 HYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDV 300
Query: 301 RTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDF 360
RTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDF
Sbjct: 301 RTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDF 360
Query: 361 NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF 420
NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF
Sbjct: 361 NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF 420
Query: 421 IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI 480
IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI
Sbjct: 421 IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI 480
Query: 481 IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD 540
IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD
Sbjct: 481 IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD 540
Query: 541 YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS 600
YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS
Sbjct: 541 YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS 600
Query: 601 ERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPP 660
ERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPP
Sbjct: 601 ERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPP 660
Query: 661 PDDNSGWDIDF 671
PDDNSGWDIDF
Sbjct: 661 PDDNSGWDIDF 671
>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
sapiens]
Length = 686
Score = 1213 bits (3139), Expect = 0.0
Identities = 612/670 (91%), Positives = 624/670 (93%), Gaps = 11/670 (1%)
Query: 12 LMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVL---------PVPSTHIGPRTTRAQ 62
L ++ I ELE L +K+E IQ+L+ +L K +SV+ ST G T+ Q
Sbjct: 18 LRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQAQKQSASTLQGEPRTKRQ 77
Query: 63 GISAEPQTYRSFHDLRQAFRKF-TKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYP 121
ISAEP + DL F KS +SKDLIKEAILDNDFMKNLELSQIQEIVDCMYP
Sbjct: 78 AISAEPTAF-DIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYP 136
Query: 122 VEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATV 181
VEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATV
Sbjct: 137 VEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATV 196
Query: 182 KTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETH 241
KTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETH
Sbjct: 197 KTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETH 256
Query: 242 YENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVR 301
YENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVR
Sbjct: 257 YENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVR 316
Query: 302 TANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFN 361
TANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFN
Sbjct: 317 TANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFN 376
Query: 362 IIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFI 421
IIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFI
Sbjct: 377 IIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFI 436
Query: 422 VRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGII 481
VRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGII
Sbjct: 437 VRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGII 496
Query: 482 YRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADY 541
YRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADY
Sbjct: 497 YRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADY 556
Query: 542 WSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSE 601
WSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSE
Sbjct: 557 WSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSE 616
Query: 602 RLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPP 661
RLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPP
Sbjct: 617 RLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPP 676
Query: 662 DDNSGWDIDF 671
DDNSGWDIDF
Sbjct: 677 DDNSGWDIDF 686
>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
Length = 762
Score = 670 bits (1728), Expect = 0.0
Identities = 358/737 (48%), Positives = 483/737 (65%), Gaps = 70/737 (9%)
Query: 1 MSELEEDFAKI---LMLKEERIKELEKRLS-------EKEEEIQELKRKLHKCQSVLPVP 50
++ELE + + + +E +KEL ++LS E EE+Q +L+K Q V+ +
Sbjct: 30 VTELERELRRKDAEIQEREYHLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQ 89
Query: 51 S----------------------THIGPRTTRAQGISAEPQTYRSFHDLRQ----AFRK- 83
+ R G+SAEP T +DL + +F K
Sbjct: 90 GGSPLQASPDKVPLEVHRKTSGLVSLHSRRGAKAGVSAEPTTRT--YDLNKPPEFSFEKA 147
Query: 84 -FTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYV 142
K K LI +A+ N F+K L+ QI+++V+CMY Y + S IIK+G+ G+ ++V
Sbjct: 148 RVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFV 207
Query: 143 MEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMM 202
+ +G++EV + L ++ FGELAILYNCTRTA+VK + NVK WA+DR+ FQ IM
Sbjct: 208 LAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMR 267
Query: 203 RTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIIS 262
RT + +Y FL+SV ++LPE+ L+K+ D LE +Y+ G+YIIR+G G TFFI++
Sbjct: 268 RTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILA 327
Query: 263 KGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEA-VTCLVIDRDSF 321
KG V VT+ + P ++TL KG++FGEKAL +DVR+AN+IA E V CLVIDR++F
Sbjct: 328 KGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETF 387
Query: 322 KHLIGGLDD--------VSNKAYEDAEAKAKY-------------------EAEAAFFAN 354
+G ++ V+N +D + AK E A F ++
Sbjct: 388 NQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSS 447
Query: 355 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ 414
+ II TLGVGGFGRVELV++K+E + FAMK ++K+HIVDT+QQEH+ SEK+I++
Sbjct: 448 SPFQNLEIIATLGVGGFGRVELVKVKNE-NVAFAMKCIRKKHIVDTKQQEHVYSEKRILE 506
Query: 415 GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 474
S FIV+LYRTFKD+KY+YML+EACLGGELW+ILRDRGSF++ T++F ACV EAF Y
Sbjct: 507 ELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDY 566
Query: 475 LHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKG 534
LH GIIYRDLKPENLILD GY KLVDFGFAKKIG G+KTWTFCGTPEYVAPE+ILNKG
Sbjct: 567 LHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKG 626
Query: 535 HDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKL 594
HD S D+WSLGIL+YELLTG+PPFSG D M TYN+IL+GI+ ++FP+KI + +LI++L
Sbjct: 627 HDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRL 686
Query: 595 CRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPE 654
CR NP+ERLGNLKNG+ DI+KH+W GFNWEGL+ +L P+ + P D S FD +P
Sbjct: 687 CRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPP 746
Query: 655 DNDEPPPDDNSGWDIDF 671
+ PPD+ SGWD DF
Sbjct: 747 EKG-MPPDELSGWDKDF 762
>gi|4826948 protein kinase, X-linked [Homo sapiens]
Length = 358
Score = 292 bits (748), Expect = 6e-79
Identities = 138/300 (46%), Positives = 208/300 (69%), Gaps = 5/300 (1%)
Query: 357 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 416
L DF+ + T+G G FGRV LV+ K+ + FA+K++ ++ +Q++H+ +EK +++
Sbjct: 46 LQDFDTLATVGTGTFGRVHLVKEKTAKH-FFALKVMSIPDVIRLKQEQHVHNEKSVLKEV 104
Query: 417 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 476
F++RL+ T+ D ++LYMLME GGEL++ LR+RG F +T FY+A ++ A YLH
Sbjct: 105 SHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLH 164
Query: 477 SKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHD 536
SK I+YRDLKPEN++LD G+ KL DFGFAKK+ +TWT CGTPEY+APE+I +KGH
Sbjct: 165 SKEIVYRDLKPENILLDRDGHIKLTDFGFAKKL--VDRTWTLCGTPEYLAPEVIQSKGHG 222
Query: 537 ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCR 596
+ D+W+LGIL++E+L+G PPF +P Y IL G I+FP+ + + +LIKKL
Sbjct: 223 RAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAG--KIDFPRHLDFHVKDLIKKLLV 280
Query: 597 DNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDN 656
+ + RLGN+KNG D++ H+WF +WE + + L PPI+P +A DTSNF+++PE++
Sbjct: 281 VDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPEND 340
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 280 bits (715), Expect = 4e-75
Identities = 140/303 (46%), Positives = 199/303 (65%), Gaps = 5/303 (1%)
Query: 354 NLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM 413
N L DF TLG G FGRV LV+ K+ E + +AMKIL K+ +V +Q EH +EK+I+
Sbjct: 38 NAGLEDFERKKTLGTGSFGRVMLVKHKATE-QYYAMKILDKQKVVKLKQIEHTLNEKRIL 96
Query: 414 QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFA 473
Q + F+VRL FKD+ LYM+ME GGE+++ LR G F + RFY A +V F
Sbjct: 97 QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156
Query: 474 YLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNK 533
YLHS +IYRDLKPENL++DH+GY ++ DFGFAK++ +TWT CGTPEY+APEIIL+K
Sbjct: 157 YLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILSK 214
Query: 534 GHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKK 593
G++ + D+W+LG+L+YE+ G PPF P++ Y I+ G + FP + + +L++
Sbjct: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRN 272
Query: 594 LCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFP 653
L + + ++R GNLKNGV DI+ HKWF +W + + + P IP DTSNFD +
Sbjct: 273 LLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYE 332
Query: 654 EDN 656
E++
Sbjct: 333 EED 335
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 280 bits (715), Expect = 4e-75
Identities = 140/303 (46%), Positives = 199/303 (65%), Gaps = 5/303 (1%)
Query: 354 NLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM 413
N L DF TLG G FGRV LV+ K+ E + +AMKIL K+ +V +Q EH +EK+I+
Sbjct: 85 NAGLEDFERKKTLGTGSFGRVMLVKHKATE-QYYAMKILDKQKVVKLKQIEHTLNEKRIL 143
Query: 414 QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFA 473
Q + F+VRL FKD+ LYM+ME GGE+++ LR G F + RFY A +V F
Sbjct: 144 QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 203
Query: 474 YLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNK 533
YLHS +IYRDLKPENL++DH+GY ++ DFGFAK++ +TWT CGTPEY+APEIIL+K
Sbjct: 204 YLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILSK 261
Query: 534 GHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKK 593
G++ + D+W+LG+L+YE+ G PPF P++ Y I+ G + FP + + +L++
Sbjct: 262 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRN 319
Query: 594 LCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFP 653
L + + ++R GNLKNGV DI+ HKWF +W + + + P IP DTSNFD +
Sbjct: 320 LLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYE 379
Query: 654 EDN 656
E++
Sbjct: 380 EED 382
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 278 bits (710), Expect = 2e-74
Identities = 142/312 (45%), Positives = 203/312 (65%), Gaps = 7/312 (2%)
Query: 344 KYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQ 403
K+E+ A A+L F I TLG G FGRV LV+ K E +AMKIL K+ +V +Q
Sbjct: 22 KWESPAQNTAHL--DQFERIKTLGTGSFGRVMLVKHK-ETGNHYAMKILDKQKVVKLKQI 78
Query: 404 EHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRF 463
EH +EK+I+Q + F+V+L +FKD+ LYM+ME GGE+++ LR G F + RF
Sbjct: 79 EHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF 138
Query: 464 YTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPE 523
Y A +V F YLHS +IYRDLKPENL++D +GY ++ DFGFAK++ +TWT CGTPE
Sbjct: 139 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTWTLCGTPE 196
Query: 524 YVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKI 583
Y+APEIIL+KG++ + D+W+LG+L+YE+ G PPF P++ Y I+ G + FP
Sbjct: 197 YLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHF 254
Query: 584 AKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASP 643
+ + +L++ L + + ++R GNLKNGV DI+ HKWF +W + + + P IP P
Sbjct: 255 SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGP 314
Query: 644 TDTSNFDSFPED 655
DTSNFD + E+
Sbjct: 315 GDTSNFDDYEEE 326
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 278 bits (710), Expect = 2e-74
Identities = 142/312 (45%), Positives = 203/312 (65%), Gaps = 7/312 (2%)
Query: 344 KYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQ 403
K+E+ A A+L F I TLG G FGRV LV+ K E +AMKIL K+ +V +Q
Sbjct: 30 KWESPAQNTAHL--DQFERIKTLGTGSFGRVMLVKHK-ETGNHYAMKILDKQKVVKLKQI 86
Query: 404 EHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRF 463
EH +EK+I+Q + F+V+L +FKD+ LYM+ME GGE+++ LR G F + RF
Sbjct: 87 EHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF 146
Query: 464 YTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPE 523
Y A +V F YLHS +IYRDLKPENL++D +GY ++ DFGFAK++ +TWT CGTPE
Sbjct: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTWTLCGTPE 204
Query: 524 YVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKI 583
Y+APEIIL+KG++ + D+W+LG+L+YE+ G PPF P++ Y I+ G + FP
Sbjct: 205 YLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHF 262
Query: 584 AKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASP 643
+ + +L++ L + + ++R GNLKNGV DI+ HKWF +W + + + P IP P
Sbjct: 263 SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGP 322
Query: 644 TDTSNFDSFPED 655
DTSNFD + E+
Sbjct: 323 GDTSNFDDYEEE 334
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 269 bits (688), Expect = 5e-72
Identities = 133/296 (44%), Positives = 196/296 (66%), Gaps = 5/296 (1%)
Query: 360 FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSD 419
F + TLG+G FGRV LV+ E +AMKIL K+ +V +Q EHI +EK+I+Q
Sbjct: 44 FERLRTLGMGSFGRVMLVR-HQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFP 102
Query: 420 FIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKG 479
F+V+L +FKD+ YLY++ME GGE+++ L+ G F + FY A VV A YLHS
Sbjct: 103 FLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLD 162
Query: 480 IIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISA 539
+I+RDLKPENL++D +GY ++ DFGFAK++ +TWT CGTPEY+APEIIL+KG++ +
Sbjct: 163 LIHRDLKPENLLIDQQGYLQVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILSKGYNKAV 220
Query: 540 DYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNP 599
D+W+LG+L+YE+ G PPF P++ Y I+ G + FP K++ + +L++ L + +
Sbjct: 221 DWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSG--RVRFPSKLSSDLKHLLRSLLQVDL 278
Query: 600 SERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPED 655
++R GNL+NGV DI+ HKWF +W + + + P IP P D SNFD + E+
Sbjct: 279 TKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEE 334
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 238 bits (607), Expect = 1e-62
Identities = 128/311 (41%), Positives = 185/311 (59%), Gaps = 7/311 (2%)
Query: 360 FNIIDTLGVGGFGRVELVQLKSEES--KTFAMKILKKRHIV-DTRQQEHIRSEKQIMQGA 416
F ++ LG GG+G+V V+ + K +AMK+L+K IV + + H R+E+ I++
Sbjct: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126
Query: 417 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 476
FIV L F+ LY+++E GGEL+T L G F + T FY A + A +LH
Sbjct: 127 KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH 186
Query: 477 SKGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIILNKGH 535
S+GIIYRDLKPEN++L +G+ KL DFG K+ I G T TFCGT EY+APEI++ GH
Sbjct: 187 SQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGH 246
Query: 536 DISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLC 595
+ + D+WSLG LMY++LTGSPPF+ + KT + I+RG + P + +A +L+KK
Sbjct: 247 NRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRG--KLALPPYLTPDARDLVKKFL 304
Query: 596 RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDS-FPE 654
+ NPS+R+G D+Q+H +F NW+ L + PP P + S D S FD+ F
Sbjct: 305 KRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTR 364
Query: 655 DNDEPPPDDNS 665
PDD +
Sbjct: 365 QTPVDSPDDTA 375
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 233 bits (595), Expect = 3e-61
Identities = 129/311 (41%), Positives = 184/311 (59%), Gaps = 7/311 (2%)
Query: 360 FNIIDTLGVGGFGRVELVQ--LKSEESKTFAMKILKKRHIV-DTRQQEHIRSEKQIMQGA 416
F ++ LG GG+G+V V+ + K FAMK+LKK IV + + H ++E+ I++
Sbjct: 91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150
Query: 417 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 476
FIV L F+ LY+++E GGEL+ L G F + T FY A + A +LH
Sbjct: 151 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 210
Query: 477 SKGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIILNKGH 535
KGIIYRDLKPEN++L+H+G+ KL DFG K+ I G T TFCGT EY+APEI++ GH
Sbjct: 211 QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGH 270
Query: 536 DISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLC 595
+ + D+WSLG LMY++LTG+PPF+G + KT + IL+ + P + + A +L+KKL
Sbjct: 271 NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK--CKLNLPPYLTQEARDLLKKLL 328
Query: 596 RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDS-FPE 654
+ N + RLG ++Q H +F NWE L + PP P + S D S FDS F
Sbjct: 329 KRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTR 388
Query: 655 DNDEPPPDDNS 665
PDD++
Sbjct: 389 QTPVDSPDDST 399
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 227 bits (579), Expect = 2e-59
Identities = 122/316 (38%), Positives = 190/316 (60%), Gaps = 11/316 (3%)
Query: 358 SDFNIIDTLGVGGFGRVELVQL--KSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG 415
S F ++ LG G FG+V LV+ S+ + +AMK+LKK + R + + E+ I+
Sbjct: 66 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATL-KVRDRVRTKMERDILVE 124
Query: 416 AHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYL 475
+ FIV+L+ F+ LY++++ GG+L+T L F + +FY A + A +L
Sbjct: 125 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 184
Query: 476 HSKGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIILNKG 534
HS GIIYRDLKPEN++LD G+ KL DFG +K+ I KK ++FCGT EY+APE++ +G
Sbjct: 185 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRG 244
Query: 535 HDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKL 594
H SAD+WS G+LM+E+LTG+ PF G D +T +IL+ + P+ ++ A +L++ L
Sbjct: 245 HTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKA--KLGMPQFLSPEAQSLLRML 302
Query: 595 CRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFD---- 650
+ NP+ RLG +GV++I++H +F +W L + + PP P+ P DT FD
Sbjct: 303 FKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFT 362
Query: 651 -SFPEDNDEPPPDDNS 665
P+D+ PP N+
Sbjct: 363 AKTPKDSPGIPPSANA 378
Score = 112 bits (279), Expect = 1e-24
Identities = 78/256 (30%), Positives = 132/256 (51%), Gaps = 21/256 (8%)
Query: 360 FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSD 419
+ + + +GVG + + K+ + FA+KI+ K T + E + + G H +
Sbjct: 422 YEVKEDIGVGSYSVCKRCIHKATNME-FAVKIIDKSKRDPTEEIEIL-----LRYGQHPN 475
Query: 420 FIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKG 479
I+ L + D KY+Y++ E GGEL + + F + + + YLH++G
Sbjct: 476 -IITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQG 534
Query: 480 IIYRDLKPENLI-LDHRGYA---KLVDFGFAKKI-GFGKKTWTFCGTPEYVAPEIILNKG 534
+++RDLKP N++ +D G ++ DFGFAK++ T C T +VAPE++ +G
Sbjct: 535 VVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQG 594
Query: 535 HDISADYWSLGILMYELLTGSPPF-SGPDPMKTYNIILRGIDMIEFP------KKIAKNA 587
+D + D WSLG+L+Y +LTG PF +GPD T IL I +F ++ A
Sbjct: 595 YDAACDIWSLGVLLYTMLTGYTPFANGPD--DTPEEILARIGSGKFSLSGGYWNSVSDTA 652
Query: 588 ANLIKKLCRDNPSERL 603
+L+ K+ +P +RL
Sbjct: 653 KDLVSKMLHVDPHQRL 668
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 227 bits (578), Expect = 3e-59
Identities = 119/312 (38%), Positives = 189/312 (60%), Gaps = 11/312 (3%)
Query: 358 SDFNIIDTLGVGGFGRVELVQ--LKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG 415
S F ++ LG G FG+V LV+ + + +AMK+LKK + R + + E+ I+
Sbjct: 69 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATL-KVRDRVRTKMERDILAD 127
Query: 416 AHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYL 475
+ F+V+L+ F+ LY++++ GG+L+T L F + +FY A + +L
Sbjct: 128 VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHL 187
Query: 476 HSKGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIILNKG 534
HS GIIYRDLKPEN++LD G+ KL DFG +K+ I KK ++FCGT EY+APE++ +G
Sbjct: 188 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQG 247
Query: 535 HDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKL 594
H SAD+WS G+LM+E+LTGS PF G D +T +IL+ + P+ ++ A +L++ L
Sbjct: 248 HSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKA--KLGMPQFLSTEAQSLLRAL 305
Query: 595 CRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDS--- 651
+ NP+ RLG+ +G ++I++H ++ +W L + + PP P+VA P DT FD+
Sbjct: 306 FKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFT 365
Query: 652 --FPEDNDEPPP 661
P+D+ PP
Sbjct: 366 SRTPKDSPGIPP 377
Score = 116 bits (291), Expect = 6e-26
Identities = 82/277 (29%), Positives = 140/277 (50%), Gaps = 25/277 (9%)
Query: 354 NLKLSDFNII-DTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQI 412
NL SD ++ +T+GVG + + K+ + +A+K++ K +++ E +
Sbjct: 420 NLVFSDGYVVKETIGVGSYSECKRCVHKATNME-YAVKVIDK-----SKRDPSEEIEILL 473
Query: 413 MQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAF 472
G H + I+ L + D K++Y++ E GGEL + + F + F + +
Sbjct: 474 RYGQHPN-IITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTV 532
Query: 473 AYLHSKGIIYRDLKPENLI-LDHRG---YAKLVDFGFAKKI-GFGKKTWTFCGTPEYVAP 527
YLHS+G+++RDLKP N++ +D G ++ DFGFAK++ T C T +VAP
Sbjct: 533 EYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAP 592
Query: 528 EIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP------K 581
E++ +G+D D WSLGIL+Y +L G PF+ P T IL I +F
Sbjct: 593 EVLKRQGYDEGCDIWSLGILLYTMLAGYTPFAN-GPSDTPEEILTRIGSGKFTLSGGNWN 651
Query: 582 KIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKW 618
+++ A +L+ K+ +P +RL K + +H W
Sbjct: 652 TVSETAKDLVSKMLHVDPHQRL-----TAKQVLQHPW 683
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 227 bits (578), Expect = 3e-59
Identities = 119/312 (38%), Positives = 189/312 (60%), Gaps = 11/312 (3%)
Query: 358 SDFNIIDTLGVGGFGRVELVQ--LKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG 415
S F ++ LG G FG+V LV+ + + +AMK+LKK + R + + E+ I+
Sbjct: 60 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATL-KVRDRVRTKMERDILAD 118
Query: 416 AHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYL 475
+ F+V+L+ F+ LY++++ GG+L+T L F + +FY A + +L
Sbjct: 119 VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHL 178
Query: 476 HSKGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIILNKG 534
HS GIIYRDLKPEN++LD G+ KL DFG +K+ I KK ++FCGT EY+APE++ +G
Sbjct: 179 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQG 238
Query: 535 HDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKL 594
H SAD+WS G+LM+E+LTGS PF G D +T +IL+ + P+ ++ A +L++ L
Sbjct: 239 HSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKA--KLGMPQFLSTEAQSLLRAL 296
Query: 595 CRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDS--- 651
+ NP+ RLG+ +G ++I++H ++ +W L + + PP P+VA P DT FD+
Sbjct: 297 FKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFT 356
Query: 652 --FPEDNDEPPP 661
P+D+ PP
Sbjct: 357 SRTPKDSPGIPP 368
Score = 116 bits (291), Expect = 6e-26
Identities = 82/277 (29%), Positives = 140/277 (50%), Gaps = 25/277 (9%)
Query: 354 NLKLSDFNII-DTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQI 412
NL SD ++ +T+GVG + + K+ + +A+K++ K +++ E +
Sbjct: 411 NLVFSDGYVVKETIGVGSYSECKRCVHKATNME-YAVKVIDK-----SKRDPSEEIEILL 464
Query: 413 MQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAF 472
G H + I+ L + D K++Y++ E GGEL + + F + F + +
Sbjct: 465 RYGQHPN-IITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTV 523
Query: 473 AYLHSKGIIYRDLKPENLI-LDHRG---YAKLVDFGFAKKI-GFGKKTWTFCGTPEYVAP 527
YLHS+G+++RDLKP N++ +D G ++ DFGFAK++ T C T +VAP
Sbjct: 524 EYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAP 583
Query: 528 EIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP------K 581
E++ +G+D D WSLGIL+Y +L G PF+ P T IL I +F
Sbjct: 584 EVLKRQGYDEGCDIWSLGILLYTMLAGYTPFAN-GPSDTPEEILTRIGSGKFTLSGGNWN 642
Query: 582 KIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKW 618
+++ A +L+ K+ +P +RL K + +H W
Sbjct: 643 TVSETAKDLVSKMLHVDPHQRL-----TAKQVLQHPW 674
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 224 bits (572), Expect = 2e-58
Identities = 121/316 (38%), Positives = 190/316 (60%), Gaps = 11/316 (3%)
Query: 358 SDFNIIDTLGVGGFGRVELVQLK--SEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG 415
S F ++ LG G +G+V LV+ S+ + +AMK+LKK + R + + E+ I+
Sbjct: 65 SQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL-KVRDRVRSKMERDILAE 123
Query: 416 AHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYL 475
+ FIV+L+ F+ LY++++ GG+L+T L F + +FY A + A +L
Sbjct: 124 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 183
Query: 476 HSKGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIILNKG 534
HS GIIYRDLKPEN++LD G+ K+ DFG +K+ I K+ ++FCGT EY+APE++ +G
Sbjct: 184 HSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRG 243
Query: 535 HDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKL 594
H SAD+WS G+LM+E+LTGS PF G D +T +IL+ + P+ ++ A +L++ L
Sbjct: 244 HTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKA--KLGMPQFLSGEAQSLLRAL 301
Query: 595 CRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFD---- 650
+ NP RLG +GV++I++H +F +W L + + PP P+V P DT +FD
Sbjct: 302 FKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFT 361
Query: 651 -SFPEDNDEPPPDDNS 665
P D+ PP N+
Sbjct: 362 ARTPTDSPGVPPSANA 377
Score = 115 bits (288), Expect = 1e-25
Identities = 83/278 (29%), Positives = 144/278 (51%), Gaps = 27/278 (9%)
Query: 354 NLKLSD-FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQI 412
N+ +D + I + +GVG + + K+ +++ +A+KI+ K +++ E +
Sbjct: 416 NIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTE-YAVKIIDK-----SKRDPSEEIEILL 469
Query: 413 MQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAF 472
G H + I+ L + D K++Y++ME GGEL + + F + + +
Sbjct: 470 RYGQHPN-IITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTM 528
Query: 473 AYLHSKGIIYRDLKPENLIL-DHRG---YAKLVDFGFAKKIGFGK-KTWTFCGTPEYVAP 527
YLHS+G+++RDLKP N++ D G ++ DFGFAK++ G T C T +VAP
Sbjct: 529 DYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAP 588
Query: 528 EIILNKGHDISADYWSLGILMYELLTGSPPF-SGPDPMKTYNIILRGIDMIEFP------ 580
E++ +G+D + D WSLGIL+Y +L G PF +GPD T IL I ++
Sbjct: 589 EVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPD--DTPEEILARIGSGKYALSGGNW 646
Query: 581 KKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKW 618
I+ A +++ K+ +P +RL ++ + KH W
Sbjct: 647 DSISDAAKDVVSKMLHVDPHQRLTAMQ-----VLKHPW 679
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 224 bits (572), Expect = 2e-58
Identities = 121/316 (38%), Positives = 190/316 (60%), Gaps = 11/316 (3%)
Query: 358 SDFNIIDTLGVGGFGRVELVQLK--SEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG 415
S F ++ LG G +G+V LV+ S+ + +AMK+LKK + R + + E+ I+
Sbjct: 57 SQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL-KVRDRVRSKMERDILAE 115
Query: 416 AHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYL 475
+ FIV+L+ F+ LY++++ GG+L+T L F + +FY A + A +L
Sbjct: 116 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 175
Query: 476 HSKGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIILNKG 534
HS GIIYRDLKPEN++LD G+ K+ DFG +K+ I K+ ++FCGT EY+APE++ +G
Sbjct: 176 HSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRG 235
Query: 535 HDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKL 594
H SAD+WS G+LM+E+LTGS PF G D +T +IL+ + P+ ++ A +L++ L
Sbjct: 236 HTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKA--KLGMPQFLSGEAQSLLRAL 293
Query: 595 CRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFD---- 650
+ NP RLG +GV++I++H +F +W L + + PP P+V P DT +FD
Sbjct: 294 FKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFT 353
Query: 651 -SFPEDNDEPPPDDNS 665
P D+ PP N+
Sbjct: 354 ARTPTDSPGVPPSANA 369
Score = 115 bits (288), Expect = 1e-25
Identities = 83/278 (29%), Positives = 144/278 (51%), Gaps = 27/278 (9%)
Query: 354 NLKLSD-FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQI 412
N+ +D + I + +GVG + + K+ +++ +A+KI+ K +++ E +
Sbjct: 408 NIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTE-YAVKIIDK-----SKRDPSEEIEILL 461
Query: 413 MQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAF 472
G H + I+ L + D K++Y++ME GGEL + + F + + +
Sbjct: 462 RYGQHPN-IITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTM 520
Query: 473 AYLHSKGIIYRDLKPENLIL-DHRG---YAKLVDFGFAKKIGFGK-KTWTFCGTPEYVAP 527
YLHS+G+++RDLKP N++ D G ++ DFGFAK++ G T C T +VAP
Sbjct: 521 DYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAP 580
Query: 528 EIILNKGHDISADYWSLGILMYELLTGSPPF-SGPDPMKTYNIILRGIDMIEFP------ 580
E++ +G+D + D WSLGIL+Y +L G PF +GPD T IL I ++
Sbjct: 581 EVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPD--DTPEEILARIGSGKYALSGGNW 638
Query: 581 KKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKW 618
I+ A +++ K+ +P +RL ++ + KH W
Sbjct: 639 DSISDAAKDVVSKMLHVDPHQRLTAMQ-----VLKHPW 671
>gi|46909587 cAMP-dependent protein kinase catalytic subunit beta
isoform 3 [Homo sapiens]
Length = 257
Score = 222 bits (565), Expect = 1e-57
Identities = 111/220 (50%), Positives = 152/220 (69%), Gaps = 3/220 (1%)
Query: 354 NLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM 413
N L DF TLG G FGRV LV+ K+ E + +AMKIL K+ +V +Q EH +EK+I+
Sbjct: 38 NAGLEDFERKKTLGTGSFGRVMLVKHKATE-QYYAMKILDKQKVVKLKQIEHTLNEKRIL 96
Query: 414 QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFA 473
Q + F+VRL FKD+ LYM+ME GGE+++ LR G F + RFY A +V F
Sbjct: 97 QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156
Query: 474 YLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNK 533
YLHS +IYRDLKPENL++DH+GY ++ DFGFAK++ +TWT CGTPEY+APEIIL+K
Sbjct: 157 YLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILSK 214
Query: 534 GHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRG 573
G++ + D+W+LG+L+YE+ G PPF P++ Y I+ G
Sbjct: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 221 bits (564), Expect = 1e-57
Identities = 118/308 (38%), Positives = 189/308 (61%), Gaps = 10/308 (3%)
Query: 358 SDFNIIDTLGVGGFGRVELVQLKS--EESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG 415
+ F ++ LG G FG+V LV+ K+ + + +AMK+LKK + R + + E+ I+
Sbjct: 71 AQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASL-KVRDRVRTKMERDILVE 129
Query: 416 AHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYL 475
+ FIV+L+ F+ LY++++ GG+++T L F + +FY A + A +L
Sbjct: 130 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHL 189
Query: 476 HSKGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIILNKG 534
H GI+YRDLKPEN++LD G+ KL DFG +K+ + KK ++FCGT EY+APE++ +G
Sbjct: 190 HQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRG 249
Query: 535 HDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKL 594
H SAD+WS G+LM+E+LTG+ PF G D +T N+IL+ + P+ ++ A +L++ L
Sbjct: 250 HSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKA--KLGMPQFLSAEAQSLLRML 307
Query: 595 CRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPE 654
+ NP+ RLG+ GV++I++H +F +W+ L K + PP P+ P DT FD PE
Sbjct: 308 FKRNPANRLGS--EGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFD--PE 363
Query: 655 DNDEPPPD 662
+ P D
Sbjct: 364 FTAKTPKD 371
Score = 106 bits (264), Expect = 8e-23
Identities = 76/270 (28%), Positives = 132/270 (48%), Gaps = 24/270 (8%)
Query: 360 FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSD 419
+ + + +GVG + + + + + FA+KI+ K +++ E + G H +
Sbjct: 426 YELKEDIGVGSYSVCKRC-IHATTNMEFAVKIIDK-----SKRDPSEEIEILMRYGQHPN 479
Query: 420 FIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKG 479
I+ L F D +Y+Y++ + GGEL + + F + + + YLH +G
Sbjct: 480 -IITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQG 538
Query: 480 IIYRDLKPENLI-LDHRGYA---KLVDFGFAKKI-GFGKKTWTFCGTPEYVAPEIILNKG 534
+++RDLKP N++ +D A ++ DFGFAK++ G T C T +VAPE+++ +G
Sbjct: 539 VVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQG 598
Query: 535 HDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP------KKIAKNAA 588
+D + D WSLG+L Y +L G PF+ P T IL I +F I+ A
Sbjct: 599 YDAACDIWSLGVLFYTMLAGYTPFAN-GPNDTPEEILLRIGNGKFSLSGGNWDNISDGAK 657
Query: 589 NLIKKLCRDNPSERLGNLKNGVKDIQKHKW 618
+L+ + +P +R + I KH W
Sbjct: 658 DLLSHMLHMDPHQRY-----TAEQILKHSW 682
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 217 bits (552), Expect = 3e-56
Identities = 112/300 (37%), Positives = 176/300 (58%), Gaps = 8/300 (2%)
Query: 355 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ 414
L L DF + LG G FG+V L + + + FA+K LKK IV + E + EK+I+
Sbjct: 616 LTLEDFKFLAVLGRGHFGKVLLSEFRPS-GELFAIKALKKGDIVARDEVESLMCEKRILA 674
Query: 415 GAHS---DFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEA 471
S F+V L+ F+ +++ +ME GG+L + F + FY+ACVV
Sbjct: 675 AVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLG 733
Query: 472 FAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEII 530
+LH I+YRDLK +NL+LD GY K+ DFG K+ +G+G +T TFCGTPE++APE++
Sbjct: 734 LQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL 793
Query: 531 LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANL 590
+ + + D+W LG+L+YE+L G PF G D + ++ I+ D + +P+ ++ A +
Sbjct: 794 TDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN--DEVRYPRFLSAEAIGI 851
Query: 591 IKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFD 650
+++L R NP RLG+ + +D++K +F WE L L PP +P+++ TD SNFD
Sbjct: 852 MRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFD 911
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 217 bits (552), Expect = 3e-56
Identities = 112/300 (37%), Positives = 176/300 (58%), Gaps = 8/300 (2%)
Query: 355 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ 414
L L DF + LG G FG+V L + + + FA+K LKK IV + E + EK+I+
Sbjct: 610 LTLEDFKFLAVLGRGHFGKVLLSEFRPS-GELFAIKALKKGDIVARDEVESLMCEKRILA 668
Query: 415 GAHS---DFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEA 471
S F+V L+ F+ +++ +ME GG+L + F + FY+ACVV
Sbjct: 669 AVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLG 727
Query: 472 FAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEII 530
+LH I+YRDLK +NL+LD GY K+ DFG K+ +G+G +T TFCGTPE++APE++
Sbjct: 728 LQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL 787
Query: 531 LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANL 590
+ + + D+W LG+L+YE+L G PF G D + ++ I+ D + +P+ ++ A +
Sbjct: 788 TDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN--DEVRYPRFLSAEAIGI 845
Query: 591 IKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFD 650
+++L R NP RLG+ + +D++K +F WE L L PP +P+++ TD SNFD
Sbjct: 846 MRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFD 905
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 215 bits (547), Expect = 1e-55
Identities = 127/389 (32%), Positives = 206/389 (52%), Gaps = 21/389 (5%)
Query: 271 EDSPSEDPVFLRTLGKGDWFGEKA---LQGEDVRTANVIAAEAVTCLVIDRDSFKHLI-- 325
E P P +LG+ D E + G+D T I + + L + +K
Sbjct: 571 EPEPPPAPPRASSLGEIDESSELRVLDIPGQDSETVFDIQNDRNSILPKSQSEYKPDTPQ 630
Query: 326 GGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESK 385
GL+ + ED ++ +++ L DF LG G FG+V L + K+ ++
Sbjct: 631 SGLEYSGIQELEDRRSQQRFQ--------FNLQDFRCCAVLGRGHFGKVLLAEYKNT-NE 681
Query: 386 TFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHS---DFIVRLYRTFKDSKYLYMLMEACL 442
FA+K LKK IV + + + EK+I + +S F+V L+ F+ +++ +ME
Sbjct: 682 MFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAA 741
Query: 443 GGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVD 502
GG+L + F + FY ACVV YLH I+YRDLK +NL+LD G+ K+ D
Sbjct: 742 GGDLMMHIHT-DVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIAD 800
Query: 503 FGFAKK-IGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGP 561
FG K+ +G+G +T TFCGTPE++APE++ + + D+W LG+L+YE+L G PF G
Sbjct: 801 FGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGD 860
Query: 562 DPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEG 621
D + ++ I+ D + +P+ ++ A +++++L R NP RLG + +D++KH +F
Sbjct: 861 DEEEVFDSIVN--DEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRL 918
Query: 622 FNWEGLRKGTLTPPIIPSVASPTDTSNFD 650
+W L + PP IP++ D SNFD
Sbjct: 919 IDWSALMDKKVKPPFIPTIRGREDVSNFD 947
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 214 bits (545), Expect = 2e-55
Identities = 118/314 (37%), Positives = 179/314 (57%), Gaps = 4/314 (1%)
Query: 338 DAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHI 397
D + + +A ++DF+ + LG G FG+V LV+ K+ K +AMKILKK I
Sbjct: 126 DNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKAS-GKYYAMKILKKEVI 184
Query: 398 VDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFE 457
+ + H +E ++++ F+ L +F+ L +ME GGEL+ L F
Sbjct: 185 IAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFS 244
Query: 458 DSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTW 516
+ TRFY A +V A YLHS I+YRDLK ENL+LD G+ K+ DFG K+ I
Sbjct: 245 EDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMK 304
Query: 517 TFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM 576
TFCGTPEY+APE++ + + + D+W LG++MYE++ G PF D K + +IL ++
Sbjct: 305 TFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--MED 362
Query: 577 IEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPI 636
I+FP+ ++ +A +L+ L +P++RLG + K+I +H +F G NW+ + L PP
Sbjct: 363 IKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPF 422
Query: 637 IPSVASPTDTSNFD 650
P V S TDT FD
Sbjct: 423 KPQVTSETDTRYFD 436
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 214 bits (545), Expect = 2e-55
Identities = 118/314 (37%), Positives = 179/314 (57%), Gaps = 4/314 (1%)
Query: 338 DAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHI 397
D + + +A ++DF+ + LG G FG+V LV+ K+ K +AMKILKK I
Sbjct: 126 DNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKAS-GKYYAMKILKKEVI 184
Query: 398 VDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFE 457
+ + H +E ++++ F+ L +F+ L +ME GGEL+ L F
Sbjct: 185 IAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFS 244
Query: 458 DSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTW 516
+ TRFY A +V A YLHS I+YRDLK ENL+LD G+ K+ DFG K+ I
Sbjct: 245 EDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMK 304
Query: 517 TFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM 576
TFCGTPEY+APE++ + + + D+W LG++MYE++ G PF D K + +IL ++
Sbjct: 305 TFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--MED 362
Query: 577 IEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPI 636
I+FP+ ++ +A +L+ L +P++RLG + K+I +H +F G NW+ + L PP
Sbjct: 363 IKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPF 422
Query: 637 IPSVASPTDTSNFD 650
P V S TDT FD
Sbjct: 423 KPQVTSETDTRYFD 436
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 214 bits (545), Expect = 2e-55
Identities = 116/309 (37%), Positives = 188/309 (60%), Gaps = 8/309 (2%)
Query: 356 KLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM-Q 414
K SDF+ + +G G FG+V L + K+EE +A+K+L+K+ I+ ++++HI SE+ ++ +
Sbjct: 94 KPSDFHFLKVIGKGSFGKVLLARHKAEEV-FYAVKVLQKKAILKKKEEKHIMSERNVLLK 152
Query: 415 GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 474
F+V L+ +F+ + LY +++ GGEL+ L+ F + RFY A + A Y
Sbjct: 153 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 212
Query: 475 LHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIILNK 533
LHS I+YRDLKPEN++LD +G+ L DFG K+ I T TFCGTPEY+APE++ +
Sbjct: 213 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQ 272
Query: 534 GHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKK 593
+D + D+W LG ++YE+L G PPF + + Y+ IL ++ I +A +L++
Sbjct: 273 PYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN--KPLQLKPNITNSARHLLEG 330
Query: 594 LCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFP 653
L + + ++RLG K+ +I+ H +F NW+ L +TPP P+V+ P D +FD P
Sbjct: 331 LLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFD--P 387
Query: 654 EDNDEPPPD 662
E +EP P+
Sbjct: 388 EFTEEPVPN 396
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 214 bits (545), Expect = 2e-55
Identities = 116/309 (37%), Positives = 188/309 (60%), Gaps = 8/309 (2%)
Query: 356 KLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM-Q 414
K SDF+ + +G G FG+V L + K+EE +A+K+L+K+ I+ ++++HI SE+ ++ +
Sbjct: 108 KPSDFHFLKVIGKGSFGKVLLARHKAEEV-FYAVKVLQKKAILKKKEEKHIMSERNVLLK 166
Query: 415 GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 474
F+V L+ +F+ + LY +++ GGEL+ L+ F + RFY A + A Y
Sbjct: 167 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 226
Query: 475 LHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIILNK 533
LHS I+YRDLKPEN++LD +G+ L DFG K+ I T TFCGTPEY+APE++ +
Sbjct: 227 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQ 286
Query: 534 GHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKK 593
+D + D+W LG ++YE+L G PPF + + Y+ IL ++ I +A +L++
Sbjct: 287 PYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN--KPLQLKPNITNSARHLLEG 344
Query: 594 LCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFP 653
L + + ++RLG K+ +I+ H +F NW+ L +TPP P+V+ P D +FD P
Sbjct: 345 LLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFD--P 401
Query: 654 EDNDEPPPD 662
E +EP P+
Sbjct: 402 EFTEEPVPN 410
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 214 bits (545), Expect = 2e-55
Identities = 116/309 (37%), Positives = 188/309 (60%), Gaps = 8/309 (2%)
Query: 356 KLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM-Q 414
K SDF+ + +G G FG+V L + K+EE +A+K+L+K+ I+ ++++HI SE+ ++ +
Sbjct: 122 KPSDFHFLKVIGKGSFGKVLLARHKAEEV-FYAVKVLQKKAILKKKEEKHIMSERNVLLK 180
Query: 415 GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 474
F+V L+ +F+ + LY +++ GGEL+ L+ F + RFY A + A Y
Sbjct: 181 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 240
Query: 475 LHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIILNK 533
LHS I+YRDLKPEN++LD +G+ L DFG K+ I T TFCGTPEY+APE++ +
Sbjct: 241 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQ 300
Query: 534 GHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKK 593
+D + D+W LG ++YE+L G PPF + + Y+ IL ++ I +A +L++
Sbjct: 301 PYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN--KPLQLKPNITNSARHLLEG 358
Query: 594 LCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFP 653
L + + ++RLG K+ +I+ H +F NW+ L +TPP P+V+ P D +FD P
Sbjct: 359 LLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFD--P 415
Query: 654 EDNDEPPPD 662
E +EP P+
Sbjct: 416 EFTEEPVPN 424
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 214 bits (545), Expect = 2e-55
Identities = 116/309 (37%), Positives = 188/309 (60%), Gaps = 8/309 (2%)
Query: 356 KLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM-Q 414
K SDF+ + +G G FG+V L + K+EE +A+K+L+K+ I+ ++++HI SE+ ++ +
Sbjct: 189 KPSDFHFLKVIGKGSFGKVLLARHKAEEV-FYAVKVLQKKAILKKKEEKHIMSERNVLLK 247
Query: 415 GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 474
F+V L+ +F+ + LY +++ GGEL+ L+ F + RFY A + A Y
Sbjct: 248 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 307
Query: 475 LHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIILNK 533
LHS I+YRDLKPEN++LD +G+ L DFG K+ I T TFCGTPEY+APE++ +
Sbjct: 308 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQ 367
Query: 534 GHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKK 593
+D + D+W LG ++YE+L G PPF + + Y+ IL ++ I +A +L++
Sbjct: 368 PYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN--KPLQLKPNITNSARHLLEG 425
Query: 594 LCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFP 653
L + + ++RLG K+ +I+ H +F NW+ L +TPP P+V+ P D +FD P
Sbjct: 426 LLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFD--P 482
Query: 654 EDNDEPPPD 662
E +EP P+
Sbjct: 483 EFTEEPVPN 491
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 214 bits (544), Expect = 3e-55
Identities = 118/336 (35%), Positives = 187/336 (55%), Gaps = 7/336 (2%)
Query: 319 DSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFF---ANLKLSDFNIIDTLGVGGFGRVE 375
+S K G D + K +++ E E A A + ++DF+ + LG G FG+V
Sbjct: 108 NSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVI 167
Query: 376 LVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLY 435
LV+ K+ + +AMKIL+K I+ + H +E +++Q F+ L F+ L
Sbjct: 168 LVREKAT-GRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLC 226
Query: 436 MLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHR 495
+ME GGEL+ L F + RFY A +V A YLHS+ ++YRD+K ENL+LD
Sbjct: 227 FVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKD 286
Query: 496 GYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTG 554
G+ K+ DFG K+ I G TFCGTPEY+APE++ + + + D+W LG++MYE++ G
Sbjct: 287 GHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCG 346
Query: 555 SPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQ 614
PF D + + +IL ++ I FP+ ++ A +L+ L + +P +RLG + K++
Sbjct: 347 RLPFYNQDHERLFELIL--MEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVM 404
Query: 615 KHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFD 650
+H++F NW+ + + L PP P V S DT FD
Sbjct: 405 EHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFD 440
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 210 bits (534), Expect = 4e-54
Identities = 115/296 (38%), Positives = 173/296 (58%), Gaps = 5/296 (1%)
Query: 357 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 416
+++F + LG G FG+V LV+ K+ + +AMKILKK IV + H +E +++Q +
Sbjct: 147 MNEFEYLKLLGKGTFGKVILVKEKAT-GRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205
Query: 417 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 476
F+ L +F+ L +ME GGEL+ L F + RFY A +V A YLH
Sbjct: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265
Query: 477 S-KGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIILNKG 534
S K ++YRDLK ENL+LD G+ K+ DFG K+ I G TFCGTPEY+APE++ +
Sbjct: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
Query: 535 HDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKL 594
+ + D+W LG++MYE++ G PF D K + +IL ++ I FP+ + A +L+ L
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--MEEIRFPRTLGPEAKSLLSGL 383
Query: 595 CRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFD 650
+ +P +RLG K+I +H++F G W+ + + L+PP P V S TDT FD
Sbjct: 384 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD 439
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 210 bits (534), Expect = 4e-54
Identities = 115/296 (38%), Positives = 173/296 (58%), Gaps = 5/296 (1%)
Query: 357 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 416
+++F + LG G FG+V LV+ K+ + +AMKILKK IV + H +E +++Q +
Sbjct: 147 MNEFEYLKLLGKGTFGKVILVKEKAT-GRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205
Query: 417 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 476
F+ L +F+ L +ME GGEL+ L F + RFY A +V A YLH
Sbjct: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265
Query: 477 S-KGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIILNKG 534
S K ++YRDLK ENL+LD G+ K+ DFG K+ I G TFCGTPEY+APE++ +
Sbjct: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
Query: 535 HDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKL 594
+ + D+W LG++MYE++ G PF D K + +IL ++ I FP+ + A +L+ L
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--MEEIRFPRTLGPEAKSLLSGL 383
Query: 595 CRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFD 650
+ +P +RLG K+I +H++F G W+ + + L+PP P V S TDT FD
Sbjct: 384 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD 439
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,123,383
Number of Sequences: 37866
Number of extensions: 1231412
Number of successful extensions: 8727
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 790
Number of HSP's successfully gapped in prelim test: 199
Number of HSP's that attempted gapping in prelim test: 5725
Number of HSP's gapped (non-prelim): 1980
length of query: 671
length of database: 18,247,518
effective HSP length: 109
effective length of query: 562
effective length of database: 14,120,124
effective search space: 7935509688
effective search space used: 7935509688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.