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Search of human proteins with 148271104
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148271104 patched domain containing 1 [Homo sapiens]
(888 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148271104 patched domain containing 1 [Homo sapiens] 1780 0.0
gi|148277106 hypothetical protein LOC442213 [Homo sapiens] 795 0.0
gi|194018513 patched domain containing 3 [Homo sapiens] 189 8e-48
gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapi... 90 1e-17
gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens] 88 3e-17
gi|134254450 patched isoform S [Homo sapiens] 82 2e-15
gi|134254435 patched isoform S [Homo sapiens] 82 2e-15
gi|134254468 patched isoform S [Homo sapiens] 82 2e-15
gi|134254452 patched isoform S [Homo sapiens] 82 2e-15
gi|134254432 patched isoform L' [Homo sapiens] 82 2e-15
gi|134254466 patched isoform M [Homo sapiens] 82 2e-15
gi|134254446 patched isoform L [Homo sapiens] 82 2e-15
gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo sapi... 70 9e-12
gi|52145305 patched 2 [Homo sapiens] 64 6e-10
gi|196049380 3-hydroxy-3-methylglutaryl-Coenzyme A reductase iso... 42 0.003
gi|4557643 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isofo... 42 0.003
gi|66932902 SREBF chaperone protein [Homo sapiens] 39 0.016
gi|25952134 dispatched A [Homo sapiens] 35 0.40
gi|19923272 xenotropic and polytropic retrovirus receptor isofor... 32 3.4
gi|42734381 tRNA-yW synthesizing protein 3 homolog isoform 1 [Ho... 31 5.8
gi|4505835 polycystin 2 [Homo sapiens] 31 5.8
gi|4506403 G protein-coupled receptor, family C, group 5, member... 31 5.8
gi|51243065 zinc finger CCHC-type and RNA binding motif 1 [Homo ... 30 7.6
gi|116812588 polycystic kidney disease 2-like 2 [Homo sapiens] 30 9.9
>gi|148271104 patched domain containing 1 [Homo sapiens]
Length = 888
Score = 1780 bits (4610), Expect = 0.0
Identities = 888/888 (100%), Positives = 888/888 (100%)
Query: 1 MLRQVLHRGLRTCFSRLGHFIASHPVFFASAPVLISILLGASFSRYQVEESVEHLLAPQH 60
MLRQVLHRGLRTCFSRLGHFIASHPVFFASAPVLISILLGASFSRYQVEESVEHLLAPQH
Sbjct: 1 MLRQVLHRGLRTCFSRLGHFIASHPVFFASAPVLISILLGASFSRYQVEESVEHLLAPQH 60
Query: 61 SLAKIERNLVNSLFPVNRSKHRLYSDLQTPGRYGRVIVTSFQKANMLDQHHTDLILKLHA 120
SLAKIERNLVNSLFPVNRSKHRLYSDLQTPGRYGRVIVTSFQKANMLDQHHTDLILKLHA
Sbjct: 61 SLAKIERNLVNSLFPVNRSKHRLYSDLQTPGRYGRVIVTSFQKANMLDQHHTDLILKLHA 120
Query: 121 AVTKIQVPRPGFNYTFAHICILNNDKTCIVDDIVHVLEELKNARATNRTNFAITYPITHL 180
AVTKIQVPRPGFNYTFAHICILNNDKTCIVDDIVHVLEELKNARATNRTNFAITYPITHL
Sbjct: 121 AVTKIQVPRPGFNYTFAHICILNNDKTCIVDDIVHVLEELKNARATNRTNFAITYPITHL 180
Query: 181 KDGRAVYNGHQLGGVTVHSKDRVKSAEAIQLTYYLQSINSLNDMVAERWESSFCDTVRLF 240
KDGRAVYNGHQLGGVTVHSKDRVKSAEAIQLTYYLQSINSLNDMVAERWESSFCDTVRLF
Sbjct: 181 KDGRAVYNGHQLGGVTVHSKDRVKSAEAIQLTYYLQSINSLNDMVAERWESSFCDTVRLF 240
Query: 241 QKSNSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDCVRSKPWLG 300
QKSNSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDCVRSKPWLG
Sbjct: 241 QKSNSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDCVRSKPWLG 300
Query: 301 LLGLVTISLATLTAAGIINLTGGKYNSTFLGVPFVMLGHGLYGTFEMLSSWRKTREDQHV 360
LLGLVTISLATLTAAGIINLTGGKYNSTFLGVPFVMLGHGLYGTFEMLSSWRKTREDQHV
Sbjct: 301 LLGLVTISLATLTAAGIINLTGGKYNSTFLGVPFVMLGHGLYGTFEMLSSWRKTREDQHV 360
Query: 361 KERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIFFNYLYVLSF 420
KERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIFFNYLYVLSF
Sbjct: 361 KERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIFFNYLYVLSF 420
Query: 421 YGSSLVFTGYIENNYQHSIFCRKVPKPEALQEKPAWYRFLLTARFSEDTAEGEEANTYES 480
YGSSLVFTGYIENNYQHSIFCRKVPKPEALQEKPAWYRFLLTARFSEDTAEGEEANTYES
Sbjct: 421 YGSSLVFTGYIENNYQHSIFCRKVPKPEALQEKPAWYRFLLTARFSEDTAEGEEANTYES 480
Query: 481 HLLVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIE 540
HLLVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIE
Sbjct: 481 HLLVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIE 540
Query: 541 YTTAQQKYFSNYSPVIGFYIYESIEYWNTSVQEDVLEYTKGFVRISWFESYLNYLRKLNV 600
YTTAQQKYFSNYSPVIGFYIYESIEYWNTSVQEDVLEYTKGFVRISWFESYLNYLRKLNV
Sbjct: 541 YTTAQQKYFSNYSPVIGFYIYESIEYWNTSVQEDVLEYTKGFVRISWFESYLNYLRKLNV 600
Query: 601 STGLPKKNFTDMLRNSFLKAPQFSHFQEDIIFSKKYNDEVDVVASRMFLVAKTMETNREE 660
STGLPKKNFTDMLRNSFLKAPQFSHFQEDIIFSKKYNDEVDVVASRMFLVAKTMETNREE
Sbjct: 601 STGLPKKNFTDMLRNSFLKAPQFSHFQEDIIFSKKYNDEVDVVASRMFLVAKTMETNREE 660
Query: 661 LYDLLETLRRLSVTSKVKFIVFNPSFVYMDRYASSLGAPLHNSCISALFLLFFSAFLVAD 720
LYDLLETLRRLSVTSKVKFIVFNPSFVYMDRYASSLGAPLHNSCISALFLLFFSAFLVAD
Sbjct: 661 LYDLLETLRRLSVTSKVKFIVFNPSFVYMDRYASSLGAPLHNSCISALFLLFFSAFLVAD 720
Query: 721 SLINVWITLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPMLSTFVLGKD 780
SLINVWITLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPMLSTFVLGKD
Sbjct: 721 SLINVWITLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPMLSTFVLGKD 780
Query: 781 FTRTKWVKNALEVHGVAILQSYLCYIVGLIPLAAVPSNLTCTLFRCLFLIAFVTFFHCFA 840
FTRTKWVKNALEVHGVAILQSYLCYIVGLIPLAAVPSNLTCTLFRCLFLIAFVTFFHCFA
Sbjct: 781 FTRTKWVKNALEVHGVAILQSYLCYIVGLIPLAAVPSNLTCTLFRCLFLIAFVTFFHCFA 840
Query: 841 ILPVILTFLPPSKKKRKEKKNPENREEIECVEMVDIDSTRVVDQITTV 888
ILPVILTFLPPSKKKRKEKKNPENREEIECVEMVDIDSTRVVDQITTV
Sbjct: 841 ILPVILTFLPPSKKKRKEKKNPENREEIECVEMVDIDSTRVVDQITTV 888
>gi|148277106 hypothetical protein LOC442213 [Homo sapiens]
Length = 829
Score = 795 bits (2052), Expect = 0.0
Identities = 409/895 (45%), Positives = 581/895 (64%), Gaps = 73/895 (8%)
Query: 1 MLRQVLHRGLRTCFSRLGHFIASHPVFFASAPVLISILLGAS-FSRYQVEESVEHLLAPQ 59
MLRQVL RGL++ RLG ++ HPVFF + P +++I G S +R+Q E +E L+AP
Sbjct: 1 MLRQVLRRGLQSFCHRLGLCVSRHPVFFLTVPAVLTITFGLSALNRFQPEGDLERLVAPS 60
Query: 60 HSLAKIERNLVNSLFPVNRSKHRLYSDLQTPGRYGRVIVTSFQKANMLDQHHTDLILKLH 119
HSLAKIER+L +SLFP LDQ + L LH
Sbjct: 61 HSLAKIERSLASSLFP-------------------------------LDQSKSQLYSDLH 89
Query: 120 AAVTKIQVPRPGFNYTFAHICILNNDKTCIVDDIVHVLEELKNARATNRTNFAITYPITH 179
PG + + +L+ ++L + + T+R +
Sbjct: 90 T---------PG---RYGRVILLSPTGD-------NILLQAEGILQTHRA-------VLE 123
Query: 180 LKDGRAVYNGHQLGGVTV--HSKD-RVKSAEAIQLTYYLQSINSLN-DMVAERWESSFCD 235
+KDGR + GHQLGGV +SKD RVKSA AIQ+TYYLQ+ S D++ E+WE+ FC
Sbjct: 124 MKDGRNSFIGHQLGGVVEVPNSKDQRVKSARAIQITYYLQTYGSATQDLIGEKWENEFCK 183
Query: 236 TVRLFQKSNSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDCVRS 295
+R Q+ + ++++Y S SL DF KTS ++ ++ SL+L++T A L SM+DC+RS
Sbjct: 184 LIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLSSSMKDCLRS 243
Query: 296 KPWLGLLGLVTISLATLTAAGIINLTGGKYNSTFLGVPFVMLGHGLYGTFEMLSSWRKTR 355
KP+LGLLG++T+ ++ +TAAGI +T GKYNST LG+PF +GHG G FE+LS WR+T+
Sbjct: 244 KPFLGLLGVLTVCISIITAAGIFFITDGKYNSTLLGIPFFAMGHGTKGVFELLSGWRRTK 303
Query: 356 EDQHVKERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIFFNYL 415
E+ K+R A Y+D M+++++T+++Y +TFG+GASPFTNIEA ++FC N C++I NY
Sbjct: 304 ENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILLNYF 363
Query: 416 YVLSFYGSSLVFTGYIENNYQHSIFCRKVPKPEALQEKPAWYRFLLTARFSEDTAEGEEA 475
Y+ SF+GS LVF G +E N HSIFC K+P E L KP W++ +++ E
Sbjct: 364 YIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSD--GHQQTSHHET 421
Query: 476 NTYESHLLVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATA 535
N Y+ H + FL+ +Y +WITN YVKPFVV+ YLIY SF+ MG LQ+S+G+++ N++A+
Sbjct: 422 NPYQHHFIQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASD 481
Query: 536 TQTIEYTTAQQKYFSNYSPVIGFYIYESIEYWNTSVQEDVLEYTKGFVRISWFESYLNYL 595
+ ++ Y QQKYFSNYSPVIGFY+YE +EYWN+SVQ+D+ GF +SW E Y +L
Sbjct: 482 SPSVSYAMVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFL 541
Query: 596 RKLNVSTGLPKKNFTDMLRNSFLKAPQFSHFQEDIIFSKKYNDEVDVVASRMFLVAKTME 655
+ NVS K +F +L++SFLK P+F HF+ DIIFSK DE +++ASR++LVA+T
Sbjct: 542 KVSNVSAN-NKSDFISVLQSSFLKKPEFQHFRNDIIFSKA-GDESNIIASRLYLVARTSR 599
Query: 656 TNREELYDLLETLRRLSVTSKVKFIVFNPSFVYMDRYASSLGAPLHNSCISALFLLFFSA 715
++E+ ++LE LR LS++ ++FIVFNPSFV+MD Y+ S+ P+ + L +L +
Sbjct: 600 DKQKEITEVLEKLRPLSLSKSIRFIVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTF 659
Query: 716 FLVADSLINVWITLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPMLSTF 775
FLV L N W+ L+V S+E GV+G MTLW V++DCIS+LCLIY +N+ ID+CAP+L TF
Sbjct: 660 FLVIHPLGNFWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTF 719
Query: 776 VLGKDFTRTKWVKNALEVHGVAILQSYLCYIVGLIPLAAVPSNLTCTLFRCLFLIAFVTF 835
VL + TRT+ +K++L+ HG AILQ+ +++GL+PL VPSNLT TLF+CL L T
Sbjct: 720 VLATEHTRTQCIKSSLQDHGTAILQNVTSFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTL 779
Query: 836 FHCFAILPVILTFLPPSKKKRKEKKNP--ENREEIECVEMVDIDSTRVVDQITTV 888
HCF ILPV LTF PPSKK K+KK + REEIEC+E+ + D +TTV
Sbjct: 780 LHCFVILPVFLTFFPPSKKHHKKKKRAKRKEREEIECIEIQENP-----DHVTTV 829
>gi|194018513 patched domain containing 3 [Homo sapiens]
Length = 767
Score = 189 bits (481), Expect = 8e-48
Identities = 155/655 (23%), Positives = 288/655 (43%), Gaps = 37/655 (5%)
Query: 10 LRTCFSRLGHFIASHPVFFASAPVLISILLGASFSRY--QVEESVEHLLAPQHSLAKIER 67
L F LG + +HP F AP++++ LG F EE +E P S AK ER
Sbjct: 123 LSRTFQWLGWQVGAHPWIFLLAPLMLTAALGTGFLYLPKDEEEDLEEHYTPVGSPAKAER 182
Query: 68 NLVNSLFPVNRSKHRLYSDLQTPGRYGRVIVTSFQKANMLDQHHTDLILKLHAAVTKIQV 127
V F N S S T + ++V S+ + +LD + KL AV ++V
Sbjct: 183 RFVQGHFTTNDSYRFSASRRSTEANFVSLLVVSYSDS-LLDPATFAEVSKLDGAVQDLRV 241
Query: 128 PRP-GFNYTFAHICILNNDKTCIVDDIVHVLEELKNARATNRTNFAITYPITHLKDGRAV 186
R G + +C C+ + + ++ + +F H
Sbjct: 242 AREKGSQIQYQQVCARYR-ALCVPPNPILYAWQVNKTLNLSSISFPAYNHGRHPLYLTGF 300
Query: 187 YNGHQLGGVTVHSKDRVKSAEAIQLTYYLQSINSLNDMVAERWESSFCDTVRLFQK--SN 244
+ G+ LGG ++ + A+A++L YYL++ + D+ +++W + D + +
Sbjct: 301 FGGYILGG-SLGMGQLLLRAKAMRLLYYLKTEDPEYDVQSKQWLTHLLDQFTNIKNILAL 359
Query: 245 SKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDCVRSKPWLGLLGL 304
K+++ +TS S + +F+ TS + IL++ A+ C DC+R+K + G+
Sbjct: 360 KKIEVVHFTSLSRQLEFEATSVTVIPVFHLAYILIILFAVTSCFRFDCIRNKMCVAAFGV 419
Query: 305 VTISLATLTAAGIINLTGGKYNSTFLGVPFVMLGHGLYGTFEMLSSWRKTREDQHVKERT 364
++ LA ++ G++ G + PF++LG G+ F M+S+W KT ++ER
Sbjct: 420 ISAFLAVVSGFGLLLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWHKTNLADDIRERM 479
Query: 365 AAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIFFNYLYVLSFYGSS 424
+ VY+ + +S ++TT ++ G ++ + + FC + + + F Y Y ++ +G+
Sbjct: 480 SNVYSKAAVSITITTITNILALYTGI--MSSFRSVQCFCIYTGMTLLFCYFYNITCFGAF 537
Query: 425 LVFTGYIENNYQHSIFCRKVPKPEALQEKPAWYRFLLTARFSEDTAEGEEANTYESHLLV 484
+ G + + C K + P W F F + E + H +
Sbjct: 538 MALDG------KREVVCLCWLK----KADPKWPSFKKFCCFPFGSVPDEHGT--DIHPIS 585
Query: 485 CFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYTTA 544
F + Y+ ++T + K FVV Y++YI ++ G V EG DL N+ + + Y
Sbjct: 586 LFFRDYFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNV 645
Query: 545 QQKYFSNYSPVIGFYIYESIEYWNTSVQEDVLEYTKGF---------VRISWFESYLNYL 595
++ YFS+Y P + + + ++YW+ V++ + TK F + W ++Y+ YL
Sbjct: 646 EENYFSDYGPRVMVIVTKKVDYWDKDVRQKLENCTKIFEKNVYVDKNLTEFWLDAYVQYL 705
Query: 596 RKLNVSTGLPKKNFTDMLRNSFLKAPQFSH-----FQEDIIFSKKYNDEVDVVAS 645
K N K F + + + P F H +II S+ + DV +S
Sbjct: 706 -KGNSQDPNEKNTFMNNIPDFLSNFPNFQHDINISSSNEIISSRGFIQTTDVSSS 759
>gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapiens]
Length = 1332
Score = 89.7 bits (221), Expect = 1e-17
Identities = 208/976 (21%), Positives = 380/976 (38%), Gaps = 173/976 (17%)
Query: 7 HRGLRTCFSRLGHFIASHPVFFASAPVLISILLGASFSRYQVEESVEHLLAPQHSLAKIE 66
H L F G ++AS P+ V+ + L A ++ L + +S A+ E
Sbjct: 334 HTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSE 393
Query: 67 RNLVNSLF-PVNRSKHR-LYSDLQTPGRYGRVIVTSFQKANMLDQHHTDLILKLHAAVTK 124
+ + F P R+ L + ++ RY +++ + +LD +L+L +
Sbjct: 394 KAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQERLRH 453
Query: 125 IQV--PRPGFNYTFAHICI--LNNDKTCIVDDIVH-VLEELKNARA-----TNRTNFAIT 174
+QV P N + IC LN D T + D ++ +L+ +N R N+T T
Sbjct: 454 LQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLLLLTANQTLMGQT 513
Query: 175 Y--------------PITHLKDGRA------------VYNGHQLGGVTVHSKDRVKSAEA 208
P+T KDG A V+ +GG KD AEA
Sbjct: 514 SQVDWKDHFLYCANAPLT-FKDGTALALSCMADYGAPVFPFLAIGGYK--GKD-YSEAEA 569
Query: 209 IQLTYYLQSINSLNDMVAER--WESSFCDTVRLFQKSNSKVKMYPYTSS-SLREDFQKTS 265
+ +T+ L + + + +A+ WE +F + +R FQ+ + + + + SL ++ +T+
Sbjct: 570 LIMTFSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTT 629
Query: 266 RVSERYLVTSLILVVTMAILCCSMQDC-----VRSKPWLGLLGLVTISLATLTAAGIINL 320
TS I++ L V SK LGL G+ + A + A G +
Sbjct: 630 AEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSY 689
Query: 321 TGGKYNSTFLGV-PFVMLGHGLYGTFEMLSSW----RKTREDQHVK-ERTAAVYADSMLS 374
G + + L V PF++L G F + + R+ E + V R A SML
Sbjct: 690 LGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLL 749
Query: 375 FSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIFFNYLYVLSFYGSSLVFTGYIENN 434
SL+ A + F +GA T + A R F S +A+ ++L +S + + L +
Sbjct: 750 CSLSEA---ICFFLGA--LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEA 804
Query: 435 YQHSIFCRKVPKPEALQEKPAWYRFLLTARFSEDTAEGEEANTYESHLLVCFLKRYYCDW 494
+ + C P QE P +GE LL+ F ++ Y +
Sbjct: 805 SRLDVCCCVKP-----QELPP-------------PGQGEG-------LLLGFFQKAYAPF 839
Query: 495 ITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYTTAQQKYFS---- 550
+ + + V+L +L +L +S G D + + ++Y +YF
Sbjct: 840 LLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAP 899
Query: 551 ---------NYSPVIGFYIYESIEYWNTSVQEDVLEYTKGFVR--------ISWFESYLN 593
N+S G S N ++Y F SW + +++
Sbjct: 900 VYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFID 959
Query: 594 YLR-----KLNVSTGLPKKNFTDMLRNSF--LK--------------------APQFSHF 626
+L +L +S G K F NS LK P F +
Sbjct: 960 WLTPSSCCRLYIS-GPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLND 1018
Query: 627 QEDIIFSK----KYNDEVD------VVASRMFLVAKTMETNREELYDLLETLRRL--SVT 674
+ +I K Y+ V+ V+ASR K ++ N ++ + L R L ++T
Sbjct: 1019 RPNIKCPKGGLAAYSTSVNLTSDGQVLASRFMAYHKPLK-NSQDYTEALRAARELAANIT 1077
Query: 675 SKVKFIV-FNPSF---------VYMDRYASSL--GAPLHNSCISALFLL--FFSAFLVAD 720
+ ++ + +P+F V+ ++Y + L G + + C+ F + +
Sbjct: 1078 ADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRS 1137
Query: 721 SLINVWITLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPMLSTFVLGKD 780
L+N+ L++V + +GFM LW + + +S++ L+ + +++ + + +F +
Sbjct: 1138 GLLNL---LSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAIS-- 1192
Query: 781 FTRTKWVKNALEV---HGVAILQSY-LCYIVGLIPLAAVPSNL-TCTLFRCLFLIAFVTF 835
T+ W++ A E G A+ + + G++ L + L FR LI +
Sbjct: 1193 -TKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGL 1251
Query: 836 FHCFAILPVILTFLPP 851
H LPVIL+++ P
Sbjct: 1252 LHGLVFLPVILSYVGP 1267
>gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens]
Length = 1278
Score = 88.2 bits (217), Expect = 3e-17
Identities = 143/770 (18%), Positives = 302/770 (39%), Gaps = 119/770 (15%)
Query: 183 GRAVYNGHQLGGVTVHSKDRVKSAEAIQLTYYLQSINSLNDMV--AERWESSFCDTVRLF 240
G V+ LGG + +A A+ +T+ + + + + + A+ WE F + V+ +
Sbjct: 538 GGPVFPWLVLGG---YDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNY 594
Query: 241 QKSNSKVKMYPYTSSSLREDFQKTSRVSERY--LVTSLILVVTMAILCCSMQDCVR---- 294
+ N + +T+ ED S+ + +++ I+ + +++ ++ C R
Sbjct: 595 KNPNLTIS---FTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLLVD 651
Query: 295 SKPWLGLLGLVTISLATLTAAGIINLTGGKYNSTFLGV-PFVMLGHGLYGTFEMLSSWRK 353
SK LG+ G++ + + + G+ + G + V PF++L G+ F ++ ++++
Sbjct: 652 SKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQR 711
Query: 354 TR--EDQHVKERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIF 411
+ + + ++ V + S L++ V F +GA + + A F + +A+F
Sbjct: 712 DERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGA--LSVMPAVHTFSLFAGLAVF 769
Query: 412 FNYLYVLSFYGSSLVFTGYIENNYQHSIFCRKVPKPEALQEKPAWYRFLLTARFSEDTAE 471
++L ++ + S L + + IFC R +ED
Sbjct: 770 IDFLLQITCFVSLLGLDIKRQEKNRLDIFC--------------------CVRGAED--- 806
Query: 472 GEEANTYESHLLVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNI 531
G ES L F K Y + +++P V+ ++ +SF++ +V G D S
Sbjct: 807 GTSVQASES-CLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLS 865
Query: 532 VATATQTIEYTTAQQKYFSNYSPVIGFYIYESIEYWNTSVQEDVL--------------- 576
+ + ++Y + +Y + P + F + E +Y ++ Q V
Sbjct: 866 MPDDSYMVDYFKSISQYL-HAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIF 924
Query: 577 ------EYTK-GFVRISWFESYLNYLRKLNVSTGLPKKNFTDMLRNSFL----------- 618
YT+ GF SW + Y ++++ S+ N TD N+ +
Sbjct: 925 NAAQLDNYTRIGFAPSSWIDDYFDWVKP--QSSCCRVDNITDQFCNASVVDPACVRCRPL 982
Query: 619 -----KAPQFSHFQEDIIF--------------SKKYNDEVDV-------VASRMFLVAK 652
+ PQ F + Y+ V++ V + F+
Sbjct: 983 TPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILLGHGTRVGATYFMTYH 1042
Query: 653 TMETNREELYDLLETLRRLSVT---------SKVKFIVFNPSFVYMDRYASSLGAPLHNS 703
T+ + D L+ R ++ S + ++ +V+ ++Y + + + N
Sbjct: 1043 TVLQTSADFIDALKKARLIASNVTETMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNL 1102
Query: 704 CIS--ALFLLFFSAFLVADSLINVWITLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGI 761
+S A+FL+ L + V + T+ V + G M LW + L+ +S++ L+
Sbjct: 1103 GVSLGAIFLVTM-VLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSC 1161
Query: 762 NYTIDNCAPMLSTFVLGKDFTRTKWVKNALEVHGVAILQSY-LCYIVGLIPLAAVPSNL- 819
+++ C+ + F + +R + + AL G ++ L G++ LA S +
Sbjct: 1162 GISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIF 1221
Query: 820 TCTLFRCLFLIAFVTFFHCFAILPVILTFLPPSKKKRKEKKNPENREEIE 869
FR + + H LPV+L+++ PS K K E + E
Sbjct: 1222 QIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAKSCATEERYKGTE 1271
>gi|134254450 patched isoform S [Homo sapiens]
Length = 1296
Score = 82.4 bits (202), Expect = 2e-15
Identities = 65/272 (23%), Positives = 126/272 (46%), Gaps = 24/272 (8%)
Query: 192 LGGVTVHSKDRVKSAEAIQLTY----------------YLQSINSLNDMVA---ERWESS 232
+GG +S ++ SA A+Q + Y+ IN D A E W+ +
Sbjct: 192 VGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRT 251
Query: 233 FCDTVRLFQKSNSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDC 292
+ + V NS K+ +T+++L + + S VS + + +L++ A L DC
Sbjct: 252 YVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDC 311
Query: 293 VRSKPWLGLLGLVTISLATLTAAGIINLTGGKYN-STFLGVPFVMLGHGLYGTFEMLSSW 351
+S+ +GL G++ ++L+ G+ +L G +N +T +PF+ LG G+ F + ++
Sbjct: 312 SKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAF 371
Query: 352 RKTREDQHV--KERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIA 409
+T +++ + ++RT + S +LT+ + F + A I A R F + +
Sbjct: 372 SETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFSLQAAVV 429
Query: 410 IFFNYLYVLSFYGSSLVFTGYIENNYQHSIFC 441
+ FN+ VL + + L Y + + IFC
Sbjct: 430 VVFNFAMVLLIFPAILSMDLYRREDRRLDIFC 461
Score = 44.7 bits (104), Expect = 4e-04
Identities = 23/74 (31%), Positives = 40/74 (54%)
Query: 483 LVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYT 542
L F +++Y ++ K V+ +L + +L G +V +G DL++IV T+ ++
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 543 TAQQKYFSNYSPVI 556
AQ KYFS Y+ I
Sbjct: 641 AAQFKYFSFYNMYI 654
Score = 31.6 bits (70), Expect = 3.4
Identities = 36/155 (23%), Positives = 66/155 (42%), Gaps = 16/155 (10%)
Query: 710 LLFFSAFLV------ADSLINVW------ITLTVVSVEFGVIGFMTLWKVELDCISVLCL 757
LLF S L A L+N W + L +++VE + G M L ++L + V+ L
Sbjct: 878 LLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVE--LFGMMGLIGIKLSAVPVVIL 935
Query: 758 IYGINYTIDNCAPMLSTFVLGKDFTRTKWVKNALEVHGVAILQSYLCYIVGLIPLAAVPS 817
I + ++ + F+ + V ALE +L + ++G++ LA
Sbjct: 936 IASVGIGVEFTVHVALAFLTAIGDKNRRAVL-ALEHMFAPVLDGAVSTLLGVLMLAGSEF 994
Query: 818 NLTCT-LFRCLFLIAFVTFFHCFAILPVILTFLPP 851
+ F L ++ + + +LPV+L+F P
Sbjct: 995 DFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
>gi|134254435 patched isoform S [Homo sapiens]
Length = 1296
Score = 82.4 bits (202), Expect = 2e-15
Identities = 65/272 (23%), Positives = 126/272 (46%), Gaps = 24/272 (8%)
Query: 192 LGGVTVHSKDRVKSAEAIQLTY----------------YLQSINSLNDMVA---ERWESS 232
+GG +S ++ SA A+Q + Y+ IN D A E W+ +
Sbjct: 192 VGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRT 251
Query: 233 FCDTVRLFQKSNSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDC 292
+ + V NS K+ +T+++L + + S VS + + +L++ A L DC
Sbjct: 252 YVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDC 311
Query: 293 VRSKPWLGLLGLVTISLATLTAAGIINLTGGKYN-STFLGVPFVMLGHGLYGTFEMLSSW 351
+S+ +GL G++ ++L+ G+ +L G +N +T +PF+ LG G+ F + ++
Sbjct: 312 SKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAF 371
Query: 352 RKTREDQHV--KERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIA 409
+T +++ + ++RT + S +LT+ + F + A I A R F + +
Sbjct: 372 SETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFSLQAAVV 429
Query: 410 IFFNYLYVLSFYGSSLVFTGYIENNYQHSIFC 441
+ FN+ VL + + L Y + + IFC
Sbjct: 430 VVFNFAMVLLIFPAILSMDLYRREDRRLDIFC 461
Score = 44.7 bits (104), Expect = 4e-04
Identities = 23/74 (31%), Positives = 40/74 (54%)
Query: 483 LVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYT 542
L F +++Y ++ K V+ +L + +L G +V +G DL++IV T+ ++
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 543 TAQQKYFSNYSPVI 556
AQ KYFS Y+ I
Sbjct: 641 AAQFKYFSFYNMYI 654
Score = 31.6 bits (70), Expect = 3.4
Identities = 36/155 (23%), Positives = 66/155 (42%), Gaps = 16/155 (10%)
Query: 710 LLFFSAFLV------ADSLINVW------ITLTVVSVEFGVIGFMTLWKVELDCISVLCL 757
LLF S L A L+N W + L +++VE + G M L ++L + V+ L
Sbjct: 878 LLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVE--LFGMMGLIGIKLSAVPVVIL 935
Query: 758 IYGINYTIDNCAPMLSTFVLGKDFTRTKWVKNALEVHGVAILQSYLCYIVGLIPLAAVPS 817
I + ++ + F+ + V ALE +L + ++G++ LA
Sbjct: 936 IASVGIGVEFTVHVALAFLTAIGDKNRRAVL-ALEHMFAPVLDGAVSTLLGVLMLAGSEF 994
Query: 818 NLTCT-LFRCLFLIAFVTFFHCFAILPVILTFLPP 851
+ F L ++ + + +LPV+L+F P
Sbjct: 995 DFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
>gi|134254468 patched isoform S [Homo sapiens]
Length = 1296
Score = 82.4 bits (202), Expect = 2e-15
Identities = 65/272 (23%), Positives = 126/272 (46%), Gaps = 24/272 (8%)
Query: 192 LGGVTVHSKDRVKSAEAIQLTY----------------YLQSINSLNDMVA---ERWESS 232
+GG +S ++ SA A+Q + Y+ IN D A E W+ +
Sbjct: 192 VGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRT 251
Query: 233 FCDTVRLFQKSNSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDC 292
+ + V NS K+ +T+++L + + S VS + + +L++ A L DC
Sbjct: 252 YVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDC 311
Query: 293 VRSKPWLGLLGLVTISLATLTAAGIINLTGGKYN-STFLGVPFVMLGHGLYGTFEMLSSW 351
+S+ +GL G++ ++L+ G+ +L G +N +T +PF+ LG G+ F + ++
Sbjct: 312 SKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAF 371
Query: 352 RKTREDQHV--KERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIA 409
+T +++ + ++RT + S +LT+ + F + A I A R F + +
Sbjct: 372 SETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFSLQAAVV 429
Query: 410 IFFNYLYVLSFYGSSLVFTGYIENNYQHSIFC 441
+ FN+ VL + + L Y + + IFC
Sbjct: 430 VVFNFAMVLLIFPAILSMDLYRREDRRLDIFC 461
Score = 44.7 bits (104), Expect = 4e-04
Identities = 23/74 (31%), Positives = 40/74 (54%)
Query: 483 LVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYT 542
L F +++Y ++ K V+ +L + +L G +V +G DL++IV T+ ++
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 543 TAQQKYFSNYSPVI 556
AQ KYFS Y+ I
Sbjct: 641 AAQFKYFSFYNMYI 654
Score = 31.6 bits (70), Expect = 3.4
Identities = 36/155 (23%), Positives = 66/155 (42%), Gaps = 16/155 (10%)
Query: 710 LLFFSAFLV------ADSLINVW------ITLTVVSVEFGVIGFMTLWKVELDCISVLCL 757
LLF S L A L+N W + L +++VE + G M L ++L + V+ L
Sbjct: 878 LLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVE--LFGMMGLIGIKLSAVPVVIL 935
Query: 758 IYGINYTIDNCAPMLSTFVLGKDFTRTKWVKNALEVHGVAILQSYLCYIVGLIPLAAVPS 817
I + ++ + F+ + V ALE +L + ++G++ LA
Sbjct: 936 IASVGIGVEFTVHVALAFLTAIGDKNRRAVL-ALEHMFAPVLDGAVSTLLGVLMLAGSEF 994
Query: 818 NLTCT-LFRCLFLIAFVTFFHCFAILPVILTFLPP 851
+ F L ++ + + +LPV+L+F P
Sbjct: 995 DFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
>gi|134254452 patched isoform S [Homo sapiens]
Length = 1296
Score = 82.4 bits (202), Expect = 2e-15
Identities = 65/272 (23%), Positives = 126/272 (46%), Gaps = 24/272 (8%)
Query: 192 LGGVTVHSKDRVKSAEAIQLTY----------------YLQSINSLNDMVA---ERWESS 232
+GG +S ++ SA A+Q + Y+ IN D A E W+ +
Sbjct: 192 VGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRT 251
Query: 233 FCDTVRLFQKSNSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDC 292
+ + V NS K+ +T+++L + + S VS + + +L++ A L DC
Sbjct: 252 YVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDC 311
Query: 293 VRSKPWLGLLGLVTISLATLTAAGIINLTGGKYN-STFLGVPFVMLGHGLYGTFEMLSSW 351
+S+ +GL G++ ++L+ G+ +L G +N +T +PF+ LG G+ F + ++
Sbjct: 312 SKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAF 371
Query: 352 RKTREDQHV--KERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIA 409
+T +++ + ++RT + S +LT+ + F + A I A R F + +
Sbjct: 372 SETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFSLQAAVV 429
Query: 410 IFFNYLYVLSFYGSSLVFTGYIENNYQHSIFC 441
+ FN+ VL + + L Y + + IFC
Sbjct: 430 VVFNFAMVLLIFPAILSMDLYRREDRRLDIFC 461
Score = 44.7 bits (104), Expect = 4e-04
Identities = 23/74 (31%), Positives = 40/74 (54%)
Query: 483 LVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYT 542
L F +++Y ++ K V+ +L + +L G +V +G DL++IV T+ ++
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 543 TAQQKYFSNYSPVI 556
AQ KYFS Y+ I
Sbjct: 641 AAQFKYFSFYNMYI 654
Score = 31.6 bits (70), Expect = 3.4
Identities = 36/155 (23%), Positives = 66/155 (42%), Gaps = 16/155 (10%)
Query: 710 LLFFSAFLV------ADSLINVW------ITLTVVSVEFGVIGFMTLWKVELDCISVLCL 757
LLF S L A L+N W + L +++VE + G M L ++L + V+ L
Sbjct: 878 LLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVE--LFGMMGLIGIKLSAVPVVIL 935
Query: 758 IYGINYTIDNCAPMLSTFVLGKDFTRTKWVKNALEVHGVAILQSYLCYIVGLIPLAAVPS 817
I + ++ + F+ + V ALE +L + ++G++ LA
Sbjct: 936 IASVGIGVEFTVHVALAFLTAIGDKNRRAVL-ALEHMFAPVLDGAVSTLLGVLMLAGSEF 994
Query: 818 NLTCT-LFRCLFLIAFVTFFHCFAILPVILTFLPP 851
+ F L ++ + + +LPV+L+F P
Sbjct: 995 DFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
>gi|134254432 patched isoform L' [Homo sapiens]
Length = 1446
Score = 82.4 bits (202), Expect = 2e-15
Identities = 65/272 (23%), Positives = 126/272 (46%), Gaps = 24/272 (8%)
Query: 192 LGGVTVHSKDRVKSAEAIQLTY----------------YLQSINSLNDMVA---ERWESS 232
+GG +S ++ SA A+Q + Y+ IN D A E W+ +
Sbjct: 342 VGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRT 401
Query: 233 FCDTVRLFQKSNSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDC 292
+ + V NS K+ +T+++L + + S VS + + +L++ A L DC
Sbjct: 402 YVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDC 461
Query: 293 VRSKPWLGLLGLVTISLATLTAAGIINLTGGKYN-STFLGVPFVMLGHGLYGTFEMLSSW 351
+S+ +GL G++ ++L+ G+ +L G +N +T +PF+ LG G+ F + ++
Sbjct: 462 SKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAF 521
Query: 352 RKTREDQHV--KERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIA 409
+T +++ + ++RT + S +LT+ + F + A I A R F + +
Sbjct: 522 SETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFSLQAAVV 579
Query: 410 IFFNYLYVLSFYGSSLVFTGYIENNYQHSIFC 441
+ FN+ VL + + L Y + + IFC
Sbjct: 580 VVFNFAMVLLIFPAILSMDLYRREDRRLDIFC 611
Score = 44.7 bits (104), Expect = 4e-04
Identities = 23/74 (31%), Positives = 40/74 (54%)
Query: 483 LVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYT 542
L F +++Y ++ K V+ +L + +L G +V +G DL++IV T+ ++
Sbjct: 731 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 790
Query: 543 TAQQKYFSNYSPVI 556
AQ KYFS Y+ I
Sbjct: 791 AAQFKYFSFYNMYI 804
Score = 31.6 bits (70), Expect = 3.4
Identities = 36/155 (23%), Positives = 66/155 (42%), Gaps = 16/155 (10%)
Query: 710 LLFFSAFLV------ADSLINVW------ITLTVVSVEFGVIGFMTLWKVELDCISVLCL 757
LLF S L A L+N W + L +++VE + G M L ++L + V+ L
Sbjct: 1028 LLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVE--LFGMMGLIGIKLSAVPVVIL 1085
Query: 758 IYGINYTIDNCAPMLSTFVLGKDFTRTKWVKNALEVHGVAILQSYLCYIVGLIPLAAVPS 817
I + ++ + F+ + V ALE +L + ++G++ LA
Sbjct: 1086 IASVGIGVEFTVHVALAFLTAIGDKNRRAVL-ALEHMFAPVLDGAVSTLLGVLMLAGSEF 1144
Query: 818 NLTCT-LFRCLFLIAFVTFFHCFAILPVILTFLPP 851
+ F L ++ + + +LPV+L+F P
Sbjct: 1145 DFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1179
>gi|134254466 patched isoform M [Homo sapiens]
Length = 1381
Score = 82.4 bits (202), Expect = 2e-15
Identities = 65/272 (23%), Positives = 126/272 (46%), Gaps = 24/272 (8%)
Query: 192 LGGVTVHSKDRVKSAEAIQLTY----------------YLQSINSLNDMVA---ERWESS 232
+GG +S ++ SA A+Q + Y+ IN D A E W+ +
Sbjct: 277 VGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRT 336
Query: 233 FCDTVRLFQKSNSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDC 292
+ + V NS K+ +T+++L + + S VS + + +L++ A L DC
Sbjct: 337 YVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDC 396
Query: 293 VRSKPWLGLLGLVTISLATLTAAGIINLTGGKYN-STFLGVPFVMLGHGLYGTFEMLSSW 351
+S+ +GL G++ ++L+ G+ +L G +N +T +PF+ LG G+ F + ++
Sbjct: 397 SKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAF 456
Query: 352 RKTREDQHV--KERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIA 409
+T +++ + ++RT + S +LT+ + F + A I A R F + +
Sbjct: 457 SETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFSLQAAVV 514
Query: 410 IFFNYLYVLSFYGSSLVFTGYIENNYQHSIFC 441
+ FN+ VL + + L Y + + IFC
Sbjct: 515 VVFNFAMVLLIFPAILSMDLYRREDRRLDIFC 546
Score = 44.7 bits (104), Expect = 4e-04
Identities = 23/74 (31%), Positives = 40/74 (54%)
Query: 483 LVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYT 542
L F +++Y ++ K V+ +L + +L G +V +G DL++IV T+ ++
Sbjct: 666 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 725
Query: 543 TAQQKYFSNYSPVI 556
AQ KYFS Y+ I
Sbjct: 726 AAQFKYFSFYNMYI 739
Score = 31.6 bits (70), Expect = 3.4
Identities = 36/155 (23%), Positives = 66/155 (42%), Gaps = 16/155 (10%)
Query: 710 LLFFSAFLV------ADSLINVW------ITLTVVSVEFGVIGFMTLWKVELDCISVLCL 757
LLF S L A L+N W + L +++VE + G M L ++L + V+ L
Sbjct: 963 LLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVE--LFGMMGLIGIKLSAVPVVIL 1020
Query: 758 IYGINYTIDNCAPMLSTFVLGKDFTRTKWVKNALEVHGVAILQSYLCYIVGLIPLAAVPS 817
I + ++ + F+ + V ALE +L + ++G++ LA
Sbjct: 1021 IASVGIGVEFTVHVALAFLTAIGDKNRRAVL-ALEHMFAPVLDGAVSTLLGVLMLAGSEF 1079
Query: 818 NLTCT-LFRCLFLIAFVTFFHCFAILPVILTFLPP 851
+ F L ++ + + +LPV+L+F P
Sbjct: 1080 DFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1114
>gi|134254446 patched isoform L [Homo sapiens]
Length = 1447
Score = 82.4 bits (202), Expect = 2e-15
Identities = 65/272 (23%), Positives = 126/272 (46%), Gaps = 24/272 (8%)
Query: 192 LGGVTVHSKDRVKSAEAIQLTY----------------YLQSINSLNDMVA---ERWESS 232
+GG +S ++ SA A+Q + Y+ IN D A E W+ +
Sbjct: 343 VGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRT 402
Query: 233 FCDTVRLFQKSNSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDC 292
+ + V NS K+ +T+++L + + S VS + + +L++ A L DC
Sbjct: 403 YVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDC 462
Query: 293 VRSKPWLGLLGLVTISLATLTAAGIINLTGGKYN-STFLGVPFVMLGHGLYGTFEMLSSW 351
+S+ +GL G++ ++L+ G+ +L G +N +T +PF+ LG G+ F + ++
Sbjct: 463 SKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAF 522
Query: 352 RKTREDQHV--KERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIA 409
+T +++ + ++RT + S +LT+ + F + A I A R F + +
Sbjct: 523 SETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFSLQAAVV 580
Query: 410 IFFNYLYVLSFYGSSLVFTGYIENNYQHSIFC 441
+ FN+ VL + + L Y + + IFC
Sbjct: 581 VVFNFAMVLLIFPAILSMDLYRREDRRLDIFC 612
Score = 44.7 bits (104), Expect = 4e-04
Identities = 23/74 (31%), Positives = 40/74 (54%)
Query: 483 LVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYT 542
L F +++Y ++ K V+ +L + +L G +V +G DL++IV T+ ++
Sbjct: 732 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 791
Query: 543 TAQQKYFSNYSPVI 556
AQ KYFS Y+ I
Sbjct: 792 AAQFKYFSFYNMYI 805
Score = 31.6 bits (70), Expect = 3.4
Identities = 36/155 (23%), Positives = 66/155 (42%), Gaps = 16/155 (10%)
Query: 710 LLFFSAFLV------ADSLINVW------ITLTVVSVEFGVIGFMTLWKVELDCISVLCL 757
LLF S L A L+N W + L +++VE + G M L ++L + V+ L
Sbjct: 1029 LLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVE--LFGMMGLIGIKLSAVPVVIL 1086
Query: 758 IYGINYTIDNCAPMLSTFVLGKDFTRTKWVKNALEVHGVAILQSYLCYIVGLIPLAAVPS 817
I + ++ + F+ + V ALE +L + ++G++ LA
Sbjct: 1087 IASVGIGVEFTVHVALAFLTAIGDKNRRAVL-ALEHMFAPVLDGAVSTLLGVLMLAGSEF 1145
Query: 818 NLTCT-LFRCLFLIAFVTFFHCFAILPVILTFLPP 851
+ F L ++ + + +LPV+L+F P
Sbjct: 1146 DFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1180
>gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo
sapiens]
Length = 1359
Score = 70.1 bits (170), Expect = 9e-12
Identities = 135/601 (22%), Positives = 237/601 (39%), Gaps = 86/601 (14%)
Query: 7 HRGLRTCFSRLGHFIASHPVFFASAPVLISILLGASFSRYQVEESVEHLLAPQHSLAKIE 66
H L F G ++AS P+ V+ + L A ++ L + +S A+ E
Sbjct: 334 HTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSE 393
Query: 67 RNLVNSLF-PVNRSKHR-LYSDLQTPGRYGRVIVTSFQKANMLDQHHTDLILKLHAAVTK 124
+ + F P R+ L + ++ RY +++ + +LD +L+L +
Sbjct: 394 KAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQERLRH 453
Query: 125 IQV--PRPGFNYTFAHICI--LNNDKTCIVDDIVH-VLEELKNARA-----TNRTNFAIT 174
+QV P N + IC LN D T + D ++ +L+ +N R N+T T
Sbjct: 454 LQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLLLLTANQTLMGQT 513
Query: 175 Y--------------PITHLKDGRA------------VYNGHQLGGVTVHSKDRVKSAEA 208
P+T KDG A V+ +GG KD AEA
Sbjct: 514 SQVDWKDHFLYCANAPLT-FKDGTALALSCMADYGAPVFPFLAIGGYK--GKD-YSEAEA 569
Query: 209 IQLTYYLQSINSLNDMVAER--WESSFCDTVRLFQKSNSKVKMYPYTSS-SLREDFQKTS 265
+ +T+ L + + + +A+ WE +F + +R FQ+ + + + + SL ++ +T+
Sbjct: 570 LIMTFSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTT 629
Query: 266 RVSERYLVTSLILVVTMAILCCSMQDC-----VRSKPWLGLLGLVTISLATLTAAGIINL 320
TS I++ L V SK LGL G+ + A + A G +
Sbjct: 630 AEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSY 689
Query: 321 TGGKYNSTFLGV-PFVMLGHGLYGTFEMLSSW----RKTREDQHVK-ERTAAVYADSMLS 374
G + + L V PF++L G F + + R+ E + V R A SML
Sbjct: 690 LGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLL 749
Query: 375 FSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIFFNYLYVLSFYGSSLVFTGYIENN 434
SL+ A + F +GA T + A R F S +A+ ++L +S + + L +
Sbjct: 750 CSLSEA---ICFFLGA--LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEA 804
Query: 435 YQHSIFCRKVPKPEALQEKPAWYRFLLTARFSEDTAEGEEANTYESHLLVCFLKRYYCDW 494
+ + C P QE P +GE LL+ F ++ Y +
Sbjct: 805 SRLDVCCCVKP-----QELPP-------------PGQGEG-------LLLGFFQKAYAPF 839
Query: 495 ITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYTTAQQKYFSNYSP 554
+ + + V+L +L +L +S G D + + ++Y +YF +P
Sbjct: 840 LLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAP 899
Query: 555 V 555
V
Sbjct: 900 V 900
Score = 47.0 bits (110), Expect = 8e-05
Identities = 30/128 (23%), Positives = 61/128 (47%), Gaps = 8/128 (6%)
Query: 729 LTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPMLSTFVLGKDFTRTKWVK 788
L++V + +GFM LW + + +S++ L+ + +++ + + +F + T+ W++
Sbjct: 1170 LSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAIS---TKPTWLE 1226
Query: 789 NALEV---HGVAILQSY-LCYIVGLIPLAAVPSNL-TCTLFRCLFLIAFVTFFHCFAILP 843
A E G A+ + + G++ L + L FR LI + H LP
Sbjct: 1227 RAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLP 1286
Query: 844 VILTFLPP 851
VIL+++ P
Sbjct: 1287 VILSYVGP 1294
Score = 33.9 bits (76), Expect = 0.69
Identities = 25/83 (30%), Positives = 44/83 (53%), Gaps = 5/83 (6%)
Query: 248 KMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDCVRSKPWLGLLGLVTI 307
+++PYT +++ + Q + + E + SL LV T A+ C + +RS GLL L++I
Sbjct: 1118 EVFPYTITNVFYE-QYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRS----GLLNLLSI 1172
Query: 308 SLATLTAAGIINLTGGKYNSTFL 330
+ + G + L G YN+ L
Sbjct: 1173 VMILVDTVGFMALWGISYNAVSL 1195
>gi|52145305 patched 2 [Homo sapiens]
Length = 1203
Score = 63.9 bits (154), Expect = 6e-10
Identities = 56/254 (22%), Positives = 110/254 (43%), Gaps = 22/254 (8%)
Query: 192 LGGVTVHSKDRVKSAEAIQLTYYLQSINSLND-------------------MVAERWESS 232
LGG+ + + AEA+Q T+ L S L + V + W+
Sbjct: 299 LGGMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQRR 358
Query: 233 FCDTVRLFQKSNSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDC 292
F + N+ +++ ++S++L + S VS +V +L++ A + DC
Sbjct: 359 FVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTMLRWDC 418
Query: 293 VRSKPWLGLLGLVTISLATLTAAGIINLTGGKYN-STFLGVPFVMLGHGLYGTFEMLSSW 351
+S+ +GL G++ ++LA + G+ L G +N +T +PF+ LG G+ F + ++
Sbjct: 419 AQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAF 478
Query: 352 RKTREDQHVKERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIF 411
+ ++ER + S LT+ + F + A I A R F + I +
Sbjct: 479 TEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAA--LVPIPALRAFSLQAAIVVG 536
Query: 412 FNYLYVLSFYGSSL 425
++ V+ + + L
Sbjct: 537 CTFVAVMLVFPAIL 550
Score = 45.1 bits (105), Expect = 3e-04
Identities = 48/192 (25%), Positives = 90/192 (46%), Gaps = 27/192 (14%)
Query: 686 FVYMDRYASSLGAPLHNSCISALFLLFFSAFLV-ADSLINVW------ITLTVVSVE-FG 737
F++ ++Y L + A+ +L FLV A L+N W + L +++VE FG
Sbjct: 951 FLFWEQYLG-----LRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFG 1005
Query: 738 VIGFMTLWKVELDCISVLCLI----YGINYTIDNCAPMLSTFVLGKDFTRTKWVKNALEV 793
++GF+ ++L I V+ L+ G+ +T+ L+T +R +ALE
Sbjct: 1006 IMGFLG---IKLSAIPVVILVASVGIGVEFTVHVALGFLTT-----QGSRNLRAAHALEH 1057
Query: 794 HGVAILQSYLCYIVGLIPLAAVPSN-LTCTLFRCLFLIAFVTFFHCFAILPVILTFL-PP 851
+ + ++GL+ LA + + F L ++ + H +LPV+L+ L PP
Sbjct: 1058 TFAPVTDGAISTLLGLLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPP 1117
Query: 852 SKKKRKEKKNPE 863
+ + K++PE
Sbjct: 1118 PEVIQMYKESPE 1129
>gi|196049380 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
isoform 2 [Homo sapiens]
Length = 835
Score = 41.6 bits (96), Expect = 0.003
Identities = 35/180 (19%), Positives = 73/180 (40%), Gaps = 9/180 (5%)
Query: 244 NSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDC--VRSKPWLGL 301
N+K+ + Y ED +S ++ ++ + + + Q+ + SK LG+
Sbjct: 40 NNKICGWNYECPKFEEDV-----LSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGI 94
Query: 302 LGLVTISLATLTAAGIINLTGGKYNSTFLGVPFVMLGHGLYGTFEMLSSWRKTREDQHVK 361
GL TI + + + +I+ + +PF +L L + + V+
Sbjct: 95 AGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVR 154
Query: 362 ERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIFFNYLYVLSFY 421
E A A +F+L + + G+G + + I CC C+++ NY ++F+
Sbjct: 155 ENIARGMAILGPTFTLDALVECLVIGVGT--MSGVRQLEIMCCFGCMSVLANYFVFMTFF 212
>gi|4557643 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform
1 [Homo sapiens]
Length = 888
Score = 41.6 bits (96), Expect = 0.003
Identities = 35/180 (19%), Positives = 73/180 (40%), Gaps = 9/180 (5%)
Query: 244 NSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDC--VRSKPWLGL 301
N+K+ + Y ED +S ++ ++ + + + Q+ + SK LG+
Sbjct: 40 NNKICGWNYECPKFEEDV-----LSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGI 94
Query: 302 LGLVTISLATLTAAGIINLTGGKYNSTFLGVPFVMLGHGLYGTFEMLSSWRKTREDQHVK 361
GL TI + + + +I+ + +PF +L L + + V+
Sbjct: 95 AGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVR 154
Query: 362 ERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIFFNYLYVLSFY 421
E A A +F+L + + G+G + + I CC C+++ NY ++F+
Sbjct: 155 ENIARGMAILGPTFTLDALVECLVIGVGT--MSGVRQLEIMCCFGCMSVLANYFVFMTFF 212
>gi|66932902 SREBF chaperone protein [Homo sapiens]
Length = 1279
Score = 39.3 bits (90), Expect = 0.016
Identities = 47/187 (25%), Positives = 79/187 (42%), Gaps = 14/187 (7%)
Query: 249 MYPYTSSSLRED------FQKTSRVSERY-LVTSLILVVTMAILCCSMQDCVRSKPWLGL 301
++P + SLR + F++ V+E LVT+ I++ D V+SK L L
Sbjct: 258 LHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLAL 317
Query: 302 LGLVTISLATLTAAGIINLTGGKYNSTFLG---VPFVMLGHGLYGTFEMLSSWRKTREDQ 358
+VT+ + L + G+ L G T G P++++ GL + S T D
Sbjct: 318 AAVVTVLSSLLMSVGLCTLFG--LTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDL 375
Query: 359 HVKERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIFFNYLYVL 418
VK R A + S A L IG FT + A + FC + + + ++ +
Sbjct: 376 EVKLRIAQGLSSESWSIMKNMATELGIILIGY--FTLVPAIQEFCLFAVVGLVSDFFLQM 433
Query: 419 SFYGSSL 425
F+ + L
Sbjct: 434 LFFTTVL 440
>gi|25952134 dispatched A [Homo sapiens]
Length = 1524
Score = 34.7 bits (78), Expect = 0.40
Identities = 34/129 (26%), Positives = 55/129 (42%), Gaps = 16/129 (12%)
Query: 335 VMLGHGLYGTFEMLSSWRKTREDQHVKERTAAVY------ADSMLSFSLTTAMYLVTFGI 388
+++G G F + W T+ D+ E + V A SM S TTA
Sbjct: 565 ILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFY---- 620
Query: 389 GASPFTNIEAARIFCCNSCIAIFFNYLYVLSFYGSSLVFTGYIENNYQHSIF-CRKVPKP 447
A+ +NI A R F + AI NY+ ++++ + +V + Y +IF C K P+
Sbjct: 621 -ANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVV----LHERYLLNIFTCFKKPQQ 675
Query: 448 EALQEKPAW 456
+ K W
Sbjct: 676 QIYDNKSCW 684
>gi|19923272 xenotropic and polytropic retrovirus receptor isoform 1
[Homo sapiens]
Length = 696
Score = 31.6 bits (70), Expect = 3.4
Identities = 26/92 (28%), Positives = 38/92 (41%), Gaps = 8/92 (8%)
Query: 386 FGIGASPFTNIEAARIFCC---NSCIAIFFNYLYVLSFYGSSLVFT---GYIENNYQHSI 439
F + +PF + A + NS I + Y++ FY L + G + NN + S
Sbjct: 379 FRVFTAPFHKVGFADFWLADQLNSLSVILMDLEYMICFYSLELKWDESKGLLPNNSEESG 438
Query: 440 FCRKVPKP--EALQEKPAWYRFLLTARFSEDT 469
C K +Q PAW RF+ R DT
Sbjct: 439 ICHKYTYGVRAIVQCIPAWLRFIQCLRRYRDT 470
>gi|42734381 tRNA-yW synthesizing protein 3 homolog isoform 1 [Homo
sapiens]
Length = 259
Score = 30.8 bits (68), Expect = 5.8
Identities = 35/143 (24%), Positives = 57/143 (39%), Gaps = 20/143 (13%)
Query: 85 SDLQTPGRYGRVIVTSFQKANMLDQHHTDL-----ILKLHAAVTKIQVPRPGFNYTFAHI 139
+DL G +V Q NM DQ T IL L + GF +
Sbjct: 18 ADLSRKGSVDEDVVELVQFLNMRDQFFTTSSCAGRILLLDRGIN-------GFEVQKQNC 70
Query: 140 C-ILNNDKTCIVDDIVHVLEELKNARATNRTNFAITYPITHLKDGR-----AVYNGHQLG 193
C +L K C+ DD++ L++ F + L+D + A+ +G +
Sbjct: 71 CWLLVTHKLCVKDDVIVALKKANGDATLKFEPFVLHVQCRQLQDAQILHSMAIDSGFRNS 130
Query: 194 GVTVHSKDRVKSAEAIQLTYYLQ 216
G+TV R K+ A++ T+ L+
Sbjct: 131 GITVGK--RGKTMLAVRSTHGLE 151
>gi|4505835 polycystin 2 [Homo sapiens]
Length = 968
Score = 30.8 bits (68), Expect = 5.8
Identities = 23/124 (18%), Positives = 56/124 (45%), Gaps = 18/124 (14%)
Query: 503 FVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYTTAQQKYFSNYSPVIGFYIYE 562
F ++F++I++++A + YL TQ +++T Q+ F+ + ++G +
Sbjct: 600 FAIMFFIIFLAYAQLAYL------------VFGTQVDDFSTFQECIFTQFRIILGDINFA 647
Query: 563 SIEYWNT---SVQEDVLEYTKGFVRISWFESYLNYLR---KLNVSTGLPKKNFTDMLRNS 616
IE N + + F+ ++ F + +N K +++ + +D++R
Sbjct: 648 EIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKG 707
Query: 617 FLKA 620
+ KA
Sbjct: 708 YHKA 711
>gi|4506403 G protein-coupled receptor, family C, group 5, member A
[Homo sapiens]
Length = 357
Score = 30.8 bits (68), Expect = 5.8
Identities = 21/53 (39%), Positives = 29/53 (54%), Gaps = 2/53 (3%)
Query: 272 LVTSLILVVTMAILCCSMQDCVRSK--PWLGLLGLVTISLATLTAAGIINLTG 322
+VTS+ ++T+ IL C +QD R K P L L + + LT A II L G
Sbjct: 39 VVTSVAFMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDG 91
>gi|51243065 zinc finger CCHC-type and RNA binding motif 1 [Homo
sapiens]
Length = 217
Score = 30.4 bits (67), Expect = 7.6
Identities = 14/23 (60%), Positives = 17/23 (73%)
Query: 850 PPSKKKRKEKKNPENREEIECVE 872
P K+K+K+KK PE EEIE VE
Sbjct: 131 PKKKEKKKKKKAPEPEEEIEEVE 153
>gi|116812588 polycystic kidney disease 2-like 2 [Homo sapiens]
Length = 613
Score = 30.0 bits (66), Expect = 9.9
Identities = 14/66 (21%), Positives = 33/66 (50%), Gaps = 12/66 (18%)
Query: 503 FVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYTTAQQKYFSNYSPVIGFYIYE 562
F ++F++I+ ++A +G+L +Q +++T Q F+ + V+G + +
Sbjct: 410 FAIMFFIIFFAYAQLGFL------------VFGSQVDDFSTFQNSIFAQFRIVLGDFNFA 457
Query: 563 SIEYWN 568
I+ N
Sbjct: 458 GIQQAN 463
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.137 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,339,185
Number of Sequences: 37866
Number of extensions: 1254232
Number of successful extensions: 4183
Number of sequences better than 10.0: 24
Number of HSP's better than 10.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 4106
Number of HSP's gapped (non-prelim): 57
length of query: 888
length of database: 18,247,518
effective HSP length: 111
effective length of query: 777
effective length of database: 14,044,392
effective search space: 10912492584
effective search space used: 10912492584
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.