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Search of human proteins with 148005039
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral
oncogene homolog isoform 2 precursor [Homo sapiens]
(972 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 1986 0.0
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 1980 0.0
gi|27262659 colony stimulating factor 1 receptor precursor [Homo... 669 0.0
gi|5453870 platelet-derived growth factor receptor alpha precurs... 536 e-152
gi|4505683 platelet-derived growth factor receptor beta precurso... 504 e-142
gi|169218115 PREDICTED: similar to KIT protein [Homo sapiens] 467 e-131
gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens] 455 e-127
gi|88979855 PREDICTED: similar to v-kit Hardy-Zuckerman 4 feline... 402 e-111
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 372 e-103
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 347 4e-95
gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [... 342 8e-94
gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [... 342 8e-94
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 291 3e-78
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 289 1e-77
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 289 1e-77
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 289 1e-77
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 289 1e-77
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 289 1e-77
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 289 1e-77
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 289 1e-77
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 287 4e-77
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 287 4e-77
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 287 4e-77
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 285 1e-76
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 269 8e-72
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 269 8e-72
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 269 8e-72
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 269 8e-72
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 265 1e-70
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 265 1e-70
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 1986 bits (5145), Expect = 0.0
Identities = 972/972 (100%), Positives = 972/972 (100%)
Query: 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD 60
MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD
Sbjct: 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD 60
Query: 61 PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV 120
PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV
Sbjct: 61 PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV 120
Query: 121 DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH 180
DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH
Sbjct: 121 DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH 180
Query: 181 RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS 240
RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS
Sbjct: 181 RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS 240
Query: 241 SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN 300
SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN
Sbjct: 241 SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN 300
Query: 301 VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE 360
VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE
Sbjct: 301 VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE 360
Query: 361 DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR 420
DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR
Sbjct: 361 DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR 420
Query: 421 LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS 480
LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS
Sbjct: 421 LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS 480
Query: 481 SAFKHNGTVECKAYNDVGKTSAYFNFAFKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILT 540
SAFKHNGTVECKAYNDVGKTSAYFNFAFKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILT
Sbjct: 481 SAFKHNGTVECKAYNDVGKTSAYFNFAFKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILT 540
Query: 541 YKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVV 600
YKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVV
Sbjct: 541 YKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVV 600
Query: 601 EATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGG 660
EATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGG
Sbjct: 601 EATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGG 660
Query: 661 PTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDM 720
PTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDM
Sbjct: 661 PTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDM 720
Query: 721 KPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLA 780
KPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLA
Sbjct: 721 KPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLA 780
Query: 781 SKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNC 840
SKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNC
Sbjct: 781 SKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNC 840
Query: 841 VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMK 900
VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMK
Sbjct: 841 VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMK 900
Query: 901 TCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTA 960
TCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTA
Sbjct: 901 TCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTA 960
Query: 961 SSSQPLLVHDDV 972
SSSQPLLVHDDV
Sbjct: 961 SSSQPLLVHDDV 972
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 1980 bits (5130), Expect = 0.0
Identities = 972/976 (99%), Positives = 972/976 (99%), Gaps = 4/976 (0%)
Query: 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD 60
MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD
Sbjct: 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD 60
Query: 61 PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV 120
PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV
Sbjct: 61 PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV 120
Query: 121 DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH 180
DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH
Sbjct: 121 DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH 180
Query: 181 RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS 240
RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS
Sbjct: 181 RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS 240
Query: 241 SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN 300
SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN
Sbjct: 241 SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN 300
Query: 301 VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE 360
VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE
Sbjct: 301 VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE 360
Query: 361 DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR 420
DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR
Sbjct: 361 DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR 420
Query: 421 LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS 480
LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS
Sbjct: 421 LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS 480
Query: 481 SAFKHNGTVECKAYNDVGKTSAYFNFAF----KEQIHPHTLFTPLLIGFVIVAGMMCIIV 536
SAFKHNGTVECKAYNDVGKTSAYFNFAF KEQIHPHTLFTPLLIGFVIVAGMMCIIV
Sbjct: 481 SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV 540
Query: 537 MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF 596
MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF
Sbjct: 541 MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF 600
Query: 597 GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC 656
GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC
Sbjct: 601 GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC 660
Query: 657 TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE 716
TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE
Sbjct: 661 TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE 720
Query: 717 YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM 776
YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM
Sbjct: 721 YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM 780
Query: 777 AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES 836
AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES
Sbjct: 781 AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES 840
Query: 837 IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY 896
IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY
Sbjct: 841 IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY 900
Query: 897 DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV 956
DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV
Sbjct: 901 DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV 960
Query: 957 GSTASSSQPLLVHDDV 972
GSTASSSQPLLVHDDV
Sbjct: 961 GSTASSSQPLLVHDDV 976
>gi|27262659 colony stimulating factor 1 receptor precursor [Homo
sapiens]
Length = 972
Score = 669 bits (1726), Expect = 0.0
Identities = 400/957 (41%), Positives = 552/957 (57%), Gaps = 62/957 (6%)
Query: 14 LLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDE 73
+LLLL V T + EPS P +L+V+ G + L C G V+W
Sbjct: 5 VLLLLLVATAWHGQGIPVIEPSVP-------ELVVKPGATVTLRCVGNGSVEWDGPPSPH 57
Query: 74 T---NENKQNEWITEKAEATNTGKYTCTNKH---GLSNSIYVFVRDPAKLF-LVDRSLYG 126
++ + T A NTG Y CT G S +I+++V+DPA+ + ++ + +
Sbjct: 58 WTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVV 117
Query: 127 KEDNDTLVRCPLTDPEV-TNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLH 185
ED D L+ C LTDP + SL +G+PL + + P G I K +
Sbjct: 118 FEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQ-DYQ 176
Query: 186 CSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIK--DVSSSVY 243
CS G+ V+S LKV+ P +++ A + GE + C+ DV+ V+
Sbjct: 177 CSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVF 236
Query: 244 STWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTT 303
+++ TKL S H + Y++ TL + +G + C A+N G + +
Sbjct: 237 L----QHNNTKLAIPQQSDFHNN-RYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSM 291
Query: 304 TLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYP 363
VV+ ++N+ N V GE ++L V EA+P + W Y+ F+D + P
Sbjct: 292 FFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLG-PFSDHQPE-P 349
Query: 364 KSEN---ESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR 420
K N + R+ L L RLK +E G Y+FL N A+ F + + PE+
Sbjct: 350 KLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWT 409
Query: 421 LVNGM--LQCVAAGFPEPTIDWYFCPGTEQRCS-ASVLPV--DVQTLNSSGPPFGKLVVQ 475
+NG L C A+G+P+P + W C G RC A VL V D S PF K+ VQ
Sbjct: 410 FINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQ 469
Query: 476 SSIDSSAFKHNGTVECKAYNDVGKTS-AYFNFAFKEQIHP--HTLFTPLLIGFVIVAGMM 532
S + +HN T EC+A+N VG S A+ + HP LFTP+++ + + ++
Sbjct: 470 SLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALL 529
Query: 533 CIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLG 592
+++++L YKY QKP Y+V+WK++E GN+Y +IDPTQLPY+ KWEFPRN L FGKTLG
Sbjct: 530 LLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLG 589
Query: 593 AGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNL 652
AGAFGKVVEATA+GL K DA + VAVKMLK +AH E+EALMSELK++S+LG H NIVNL
Sbjct: 590 AGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNL 649
Query: 653 LGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFI---CSKQEDHAEAALYKNLLHSKESS 709
LGACT GGP LVITEYCCYGDLLNFLRRK ++ + S +D YKN+ K+
Sbjct: 650 LGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYV 709
Query: 710 CSDS------TNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLE 763
DS + Y++M+P V T ++ S+ E+D+ ++D L+L
Sbjct: 710 RRDSGFSSQGVDTYVEMRP-----VSTSSND-------SFSEQDLD----KEDGRPLELR 753
Query: 764 DLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKG 823
DLL FS QVA+GMAFLASKNCIHRD+AARN+LLT+G + KI DFGLARDI NDSNY+VKG
Sbjct: 754 DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKG 813
Query: 824 NARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGF 883
NARLPVKWMAPESIF+CVYT +SDVWSYGI LWE+FSLG +PYPG+ V+SKFYK++K+G+
Sbjct: 814 NARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGY 873
Query: 884 RMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISES-TNHIYSNLANCS 939
+M P AP +Y IM+ CW +P RPTF+QI +++Q E Y+NL + S
Sbjct: 874 QMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSS 930
>gi|5453870 platelet-derived growth factor receptor alpha precursor
[Homo sapiens]
Length = 1089
Score = 536 bits (1381), Expect = e-152
Identities = 352/965 (36%), Positives = 504/965 (52%), Gaps = 89/965 (9%)
Query: 35 SPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETN--------ENKQNEWIT-- 84
S PSI P +++ +V++ L C V W + + +E + EN ++T
Sbjct: 26 SLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVL 85
Query: 85 --EKAEATNTGKYTCTNKHGLSNS-------IYVFVRDPAKLF----LVDRSLYGKEDND 131
A A +TG YTC H + IY++V DP F + D + ++D+
Sbjct: 86 EVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDS 145
Query: 132 TLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQE 191
++ C TDPE T +L +G +P D + G Y C +
Sbjct: 146 AIIPCRTTDPE-TPVTLHNSEGV-VPASY----DSRQGFNGTFTVGPYI-----CEATVK 194
Query: 192 GKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWK---- 247
GK + F + A + + + + + GE VTC + + + V W
Sbjct: 195 GKKFQTIPFNVYALKATSELDL-EMEALKTVYKSGETIVVTCAVFN-NEVVDLQWTYPGE 252
Query: 248 -RENSQTKLQE-KYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVT--T 303
+ T L+E K S + TLT+ A V DSG + C A
Sbjct: 253 VKGKGITMLEEIKVPS-------IKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKV 305
Query: 304 TLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYP 363
T+ V +KGFI I P + VN E +VE A+P P W+ N T + +
Sbjct: 306 TISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRIS-WLKNNLTLIENLTEIT 364
Query: 364 KS-ENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLV 422
E IRY S+L L R K + G YT + N D + F + IL
Sbjct: 365 TDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDH 424
Query: 423 NGM-----LQCVAAGFPEPTIDWYFCPGTEQ---RCSASVLPVDVQTLNSSGPPFGKLVV 474
+G ++C A G P P I+W C ++ S ++L +V + + + V
Sbjct: 425 HGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTV 484
Query: 475 QSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKEQIHPHTLFTPLLIGFVIVAGMMCI 534
+ + + + V C A N +G + T+ +L+ VIV ++ +
Sbjct: 485 EGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIV--IISL 542
Query: 535 IVMILTYKYLQKPMYEVQWKVVEEIN--GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLG 592
IV+++ +K QKP YE++W+V+E I+ G+ Y+Y+DP QLPYD +WEFPR+ L G+ LG
Sbjct: 543 IVLVVIWK--QKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG 600
Query: 593 AGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNL 652
+GAFGKVVE TAYGL +S M VAVKMLKP+A +E++ALMSELK++++LG H+NIVNL
Sbjct: 601 SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL 660
Query: 653 LGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCS- 711
LGACT GP +ITEYC YGDL+N+L + RDSF+ E + L + ES+ S
Sbjct: 661 LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY 720
Query: 712 -----DSTNEYMDMKPG--VSYV-------VPTKADKRRSV--RIGSY-----IERDVTP 750
++ +YMDMK YV V +D +RS+ R SY ++ +V
Sbjct: 721 VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN 780
Query: 751 AIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLA 810
+ +D+ L L DLLSF+YQVA+GM FLASKNC+HRDLAARN+LL G+I KICDFGLA
Sbjct: 781 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA 840
Query: 811 RDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMP 870
RDI +DSNYV KG+ LPVKWMAPESIF+ +YT SDVWSYGI LWE+FSLG +PYPGM
Sbjct: 841 RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM 900
Query: 871 VDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNH 930
VDS FY IK G+RM P+HA +E+Y+IM CW+++P KRP+F + +++E +
Sbjct: 901 VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK 960
Query: 931 IYSNL 935
Y +
Sbjct: 961 SYEKI 965
>gi|4505683 platelet-derived growth factor receptor beta precursor
[Homo sapiens]
Length = 1106
Score = 504 bits (1298), Expect = e-142
Identities = 353/993 (35%), Positives = 514/993 (51%), Gaps = 105/993 (10%)
Query: 11 LCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEI 70
L LLLLL +P +S G P PG +L++ V L C+ V W
Sbjct: 18 LLSLLLLL-------EPQISQGLVVTP---PGP-ELVLNVSSTFVLTCSGSAPVVWERMS 66
Query: 71 LDETNE--NKQNEWITEKAEATN-----TGKYTCTNK--HGLSNS----IYVFVRDPAKL 117
+ E Q+ + TN TG+Y CT+ GL +Y+FV DP
Sbjct: 67 QEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVG 126
Query: 118 FLVDRS----LYGKEDNDTLVRCPLTDPE--VTNYSLKGCQGKPLPKDLRFIPDPKAGIM 171
FL + + ++ E + + C +TDP+ VT + KG P+P D + G
Sbjct: 127 FLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYD------HQRGFS 180
Query: 172 IKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTV 231
R+Y +C D+E S + L+V VSV+ ++R+GE T+
Sbjct: 181 GIFEDRSY--ICKTTIGDREVDSDAYYVYRLQVSSIN-----VSVNAVQTVVRQGENITL 233
Query: 232 TCTIKDVSSSVYS---TWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVF 288
C + + + V + T+ R+ S +L E + D Y ++ L I SA + DSG +
Sbjct: 234 MCIV--IGNEVVNFEWTYPRKESG-RLVEPVTDFLL-DMPYHIRSILHIPSAELEDSGTY 289
Query: 289 MCYANNTFGSAN--VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQ 346
C + + VV+ G++ + + T F + L V +EA+P P
Sbjct: 290 TCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPT-V 348
Query: 347 QWIYMNRTFTDK--WEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIA 404
W NRT D E + N S RYVSEL L R+K E G YT + D ++
Sbjct: 349 LWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLS 408
Query: 405 FNVYVNTKPEIL----TYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPV--- 457
F + +N +L ++ ++C G P+P I W C + RC + P
Sbjct: 409 FQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLK-RCPRELPPTLLG 467
Query: 458 -------DVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKE 510
++T + + V S++ +V C N VG+ + +
Sbjct: 468 NSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQ------EV 521
Query: 511 QIHPHTL-FTPLLIGFVIVAGMMCII-VMILTYKYLQKPMYEVQWKVVEEIN--GNNYVY 566
+ PH+L F ++I ++ ++ II ++IL + +KP YE++WKV+E ++ G+ Y+Y
Sbjct: 522 IVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIY 581
Query: 567 IDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAH 626
+DP QLPYD WE PR++L G+TLG+GAFG+VVEATA+GL S A M VAVKMLK +A
Sbjct: 582 VDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTAR 641
Query: 627 LTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFI 686
+E++ALMSELK++S+LG H+N+VNLLGACT GGP +ITEYC YGDL+++L R + +F+
Sbjct: 642 SSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFL 701
Query: 687 C--SKQEDHAEAALYKNLLH------SKESSCSDSTNEYMDMKP--GVSYV--VPTKAD- 733
S + A LY N L S S +S YMDM V YV + K D
Sbjct: 702 QHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDV 761
Query: 734 KRRSVRIGSYI-----------ERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK 782
K + +Y+ ER ++ + + L DL+ FSYQVA GM FLASK
Sbjct: 762 KYADIESSNYMAPYDNYVPSAPERTCRATLINESPV-LSYMDLVGFSYQVANGMEFLASK 820
Query: 783 NCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVY 842
NC+HRDLAARN+L+ G++ KICDFGLARDI DSNY+ KG+ LP+KWMAPESIFN +Y
Sbjct: 821 NCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLY 880
Query: 843 TFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTC 902
T SDVWS+GI LWE+F+LG +PYP +P++ +FY IK G+RM P HA E+Y+IM+ C
Sbjct: 881 TTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKC 940
Query: 903 WDADPLKRPTFKQIVQLIEKQISESTNHIYSNL 935
W+ RP F Q+V L+E+ + E Y +
Sbjct: 941 WEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQV 973
>gi|169218115 PREDICTED: similar to KIT protein [Homo sapiens]
Length = 245
Score = 467 bits (1202), Expect = e-131
Identities = 228/243 (93%), Positives = 233/243 (95%), Gaps = 4/243 (1%)
Query: 318 MINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSEL 377
MINTTVFVNDGENVDLIVEYEAFPKPEHQQWI +NRTFTDKWEDYPKSENESNIRYVSEL
Sbjct: 1 MINTTVFVNDGENVDLIVEYEAFPKPEHQQWISLNRTFTDKWEDYPKSENESNIRYVSEL 60
Query: 378 HLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPT 437
HLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVA GFPEPT
Sbjct: 61 HLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAPGFPEPT 120
Query: 438 IDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDV 497
IDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDV
Sbjct: 121 IDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDV 180
Query: 498 GKTSAYFNFAF----KEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQW 553
GKTSAYFNFAF KEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPM +
Sbjct: 181 GKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMMKYSG 240
Query: 554 KVV 556
+++
Sbjct: 241 RLL 243
>gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens]
Length = 993
Score = 455 bits (1170), Expect = e-127
Identities = 276/726 (38%), Positives = 398/726 (54%), Gaps = 42/726 (5%)
Query: 223 LREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLT----IS 278
L+ GE + C V+ TW+ EN K E+ N + ++ R +S
Sbjct: 262 LKVGEPLWIRCKAVHVNHGFGLTWELEN---KALEEGNYFEMSTYSTNRTMIRILFAFVS 318
Query: 279 SARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYE 338
S ND+G + C ++ + + T +V+KGFIN + ++ E V ++
Sbjct: 319 SVARNDTGYYTCSSSKHPSQSALVT---IVEKGFINATNS-SEDYEIDQYEEFCFSVRFK 374
Query: 339 AFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSD 398
A+P+ W + ++F + + + S ++ + H + G Y F N D
Sbjct: 375 AYPQIRCT-WTFSRKSFPCEQKGLDNGYSIS--KFCNHKH-------QPGEYIFHAENDD 424
Query: 399 VNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVD 458
F + + KP++L C + G+P P+ W C C+ +
Sbjct: 425 AQFTKMFTLNIRRKPQVLA--EASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITE-G 481
Query: 459 VQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKEQIHPHTLF 518
V ++ FG+ V S+++ S V+C AYN +G TS P F
Sbjct: 482 VWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLG-TSCETILLNSPGPFP---F 537
Query: 519 TPLLIGFVIVAGMMCIIVMILT----YKYLQKPMYEVQWKVVEEING--NNYVYIDPTQL 572
I F G+ + +++LT +KY ++ YE Q ++V+ N Y Y+D +
Sbjct: 538 IQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREY 597
Query: 573 PYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREA 632
YD KWEFPR L FGK LG+GAFGKV+ ATAYG+ K+ ++ VAVKMLK A +EREA
Sbjct: 598 EYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREA 657
Query: 633 LMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQED 692
LMSELK+++ LG+H NIVNLLGACT+ GP +I EYCCYGDLLN+LR KR+ F + E
Sbjct: 658 LMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEI 717
Query: 693 HAEA--ALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTP 750
E + Y SS S + + P + + S IE +
Sbjct: 718 FKEHNFSFYPTFQSHPNSSMPGSRE--VQIHPDSDQISGLHGNSFHSE---DEIEYENQK 772
Query: 751 AIMEDDEL-ALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGL 809
+ E+++L L EDLL F+YQVAKGM FL K+C+HRDLAARN+L+THG++ KICDFGL
Sbjct: 773 RLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGL 832
Query: 810 ARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGM 869
ARDI +DSNYVV+GNARLPVKWMAPES+F +YT +SDVWSYGI LWE+FSLG +PYPG+
Sbjct: 833 ARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGI 892
Query: 870 PVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTN 929
PVD+ FYK+I+ GF+M P +A E+Y IM++CW D KRP+F + + Q++++
Sbjct: 893 PVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEE 952
Query: 930 HIYSNL 935
+Y N+
Sbjct: 953 AMYQNV 958
Score = 35.4 bits (80), Expect = 0.26
Identities = 22/84 (26%), Positives = 36/84 (42%), Gaps = 5/84 (5%)
Query: 372 RYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYV-NTKPEILT--YDRLVNGM--L 426
R V + + ++ T+ G Y + + N I F V + NT L Y R + L
Sbjct: 123 RGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDAL 182
Query: 427 QCVAAGFPEPTIDWYFCPGTEQRC 450
C++ PEP ++W C + C
Sbjct: 183 VCISESVPEPIVEWVLCDSQGESC 206
>gi|88979855 PREDICTED: similar to v-kit Hardy-Zuckerman 4 feline
sarcoma viral oncogene homolog [Homo sapiens]
Length = 208
Score = 402 bits (1032), Expect = e-111
Identities = 197/198 (99%), Positives = 197/198 (99%)
Query: 113 DPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMI 172
DPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMI
Sbjct: 5 DPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMI 64
Query: 173 KSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVT 232
KSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVT
Sbjct: 65 KSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVT 124
Query: 233 CTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYA 292
CTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYA
Sbjct: 125 CTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYA 184
Query: 293 NNTFGSANVTTTLEVVDK 310
NNTFGSANVTTTLEVV K
Sbjct: 185 NNTFGSANVTTTLEVVGK 202
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 372 bits (956), Expect = e-103
Identities = 247/677 (36%), Positives = 366/677 (54%), Gaps = 75/677 (11%)
Query: 273 ATLTISSARVNDSGVFMCYANNTFGSA--NVTTTLEVVDKGFINIFPMINTTVFVNDGEN 330
+TL ++ +R+ SG+++C A+N G+ N++ + V GF +N +GE+
Sbjct: 520 STLVVADSRI--SGIYICIASNKVGTVGRNISFYITDVPNGF-----HVNLEKMPTEGED 572
Query: 331 VDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNI--RYVSELHLTRLKGT--E 386
+ L F + WI + RT ++ Y S+ + I + L+LT + + +
Sbjct: 573 LKLSCTVNKFLYRD-VTWILL-RTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQD 630
Query: 387 GGTYTFLVSNSDVNAAIAFNVYVNTKPEILTY------DRLV----NGMLQCVAAGFPEP 436
GTY N I + + + Y D V + L C A G PEP
Sbjct: 631 SGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEP 690
Query: 437 TIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYND 496
I W+ Q+ +L GP L ++ + G CKA N
Sbjct: 691 QITWFKNNHKIQQEPGIIL----------GPGSSTLFIERVTEED----EGVYHCKATNQ 736
Query: 497 VG--KTSAYFNFAFKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWK 554
G ++SAY L T + VA + +++ L + +++ E++
Sbjct: 737 KGSVESSAYLTVQGTSDKSNLELIT---LTCTCVAATLFWLLLTLFIRKMKRSSSEIKTD 793
Query: 555 VVEEINGNNYVYIDPT--QLPYD-HKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSD 611
+ I + V +D +LPYD KWEF R RL GK+LG GAFGKVV+A+A+G+ KS
Sbjct: 794 YLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSP 853
Query: 612 AAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTI-GGPTLVITEYCC 670
TVAVKMLK A +E +ALM+ELK+L+++G+H+N+VNLLGACT GGP +VI EYC
Sbjct: 854 TCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCK 913
Query: 671 YGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPT 730
YG+L N+L+ KRD F +K +AAL+ K M+PG+
Sbjct: 914 YGNLSNYLKSKRDLFFLNK-----DAALHMEPKKEK-------------MEPGLEQGKKP 955
Query: 731 KADKRRSVR--IGSYIERDVTPAIMEDDELA-------LDLEDLLSFSYQVAKGMAFLAS 781
+ D S S + D + + +E++E + + +EDL+S+S+QVA+GM FL+S
Sbjct: 956 RLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSS 1015
Query: 782 KNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCV 841
+ CIHRDLAARNILL+ + KICDFGLARDI + +YV KG+ RLP+KWMAPESIF+ +
Sbjct: 1016 RKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKI 1075
Query: 842 YTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKT 901
Y+ +SDVWSYG+ LWE+FSLG SPYPG+ +D F ++EG RM +PE++ E+Y IM
Sbjct: 1076 YSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLD 1135
Query: 902 CWDADPLKRPTFKQIVQ 918
CW DP +RP F ++V+
Sbjct: 1136 CWHRDPKERPRFAELVE 1152
Score = 93.2 bits (230), Expect = 1e-18
Identities = 122/500 (24%), Positives = 207/500 (41%), Gaps = 81/500 (16%)
Query: 8 WD---FLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFV 64
WD LC LL L + TGSS S + P + + I++ G + L C
Sbjct: 5 WDTGVLLCALLSCLLL-TGSSSGS----KLKDPELSLKGTQHIMQAGQTLHLQCRGEAAH 59
Query: 65 KWTF-EILDETNEN------------KQ--NEWITEKAEATNTGKYTC-------TNKHG 102
KW+ E++ + +E KQ + A+A +TG Y+C + K
Sbjct: 60 KWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKE 119
Query: 103 LSNSIYVFVRDPAKLFL-----VDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLP 157
++IY+F+ D + F+ + ++ E + ++ C +T P +T K +P
Sbjct: 120 TESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIP 179
Query: 158 KDLRFIPDPKAGIMIKSVKRAYHRL-CLHCSVDQEGKSVLSEKFILKVRPAFKAVPV-VS 215
R I D + G +I + Y + L C G L + L R + V +S
Sbjct: 180 DGKRIIWDSRKGFIISNA--TYKEIGLLTCEATVNGH--LYKTNYLTHRQTNTIIDVQIS 235
Query: 216 VSKASYLLREGEEFTVTCTIKD-VSSSVYSTWK---RENSQTKLQEKYN-SWHHGDFNYE 270
+ LLR G + CT +++ V TW +N + ++ + + S H + Y
Sbjct: 236 TPRPVKLLR-GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFY- 293
Query: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGE- 329
+ LTI + D G++ C + +V T++ + DK FI + + G+
Sbjct: 294 --SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKR 351
Query: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGT 389
+ L ++ +AFP PE W+ T+K Y I+ V+E + G
Sbjct: 352 SYRLSMKVKAFPSPE-VVWLKDGLPATEKSARYLTRGYSLIIKDVTE--------EDAGN 402
Query: 390 YTFLVS--NSDVNAAIAFNVYVNTKPEILTYDRLVNG-------------MLQCVAAGFP 434
YT L+S S+V + + VN KP+I Y++ V+ +L C A G P
Sbjct: 403 YTILLSIKQSNVFKNLTATLIVNVKPQI--YEKAVSSFPDPALYPLGSRQILTCTAYGIP 460
Query: 435 EPTIDWYFCP----GTEQRC 450
+PTI W++ P +E RC
Sbjct: 461 QPTIKWFWHPCNHNHSEARC 480
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 347 bits (889), Expect = 4e-95
Identities = 207/520 (39%), Positives = 291/520 (55%), Gaps = 74/520 (14%)
Query: 426 LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKH 485
+ C A+G P P I W+ T S VL + L +I +
Sbjct: 686 VSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNL--------------TIRRVRKED 731
Query: 486 NGTVECKAYNDVGKTSAYFNFAFKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQ 545
G C+A + +G F + L +L+G ++A ++++I+
Sbjct: 732 EGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIIL----- 786
Query: 546 KPMYEVQWKVVEEINGNNY------VYIDPTQLPYDH----------KWEFPRNRLSFGK 589
+ V+ NG + +DP +LP D KWEFPR+RL GK
Sbjct: 787 --------RTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGK 838
Query: 590 TLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNI 649
LG GAFG+V+EA A+G+ K+ TVAVKMLK A +E ALMSELK+L ++G+H+N+
Sbjct: 839 PLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNV 898
Query: 650 VNLLGACTI-GGPTLVITEYCCYGDLLNFLRRKRDSFICSKQE--------DHAEAALY- 699
VNLLGACT GGP +VI E+C +G+L +LR KR+ F+ K + D+ A
Sbjct: 899 VNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVD 958
Query: 700 -KNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDEL 758
K L S SS S +++ +++ K S +E + P + D L
Sbjct: 959 LKRRLDSITSSQSSASSGFVEEKSL------------------SDVEEEEAPEDLYKDFL 1000
Query: 759 ALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSN 818
L E L+ +S+QVAKGM FLAS+ CIHRDLAARNILL+ + KICDFGLARDI D +
Sbjct: 1001 TL--EHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPD 1058
Query: 819 YVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKM 878
YV KG+ARLP+KWMAPE+IF+ VYT +SDVWS+G+ LWE+FSLG+SPYPG+ +D +F +
Sbjct: 1059 YVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRR 1118
Query: 879 IKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 918
+KEG RM +P++ EMY M CW +P +RPTF ++V+
Sbjct: 1119 LKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVE 1158
Score = 66.6 bits (161), Expect = 1e-10
Identities = 101/483 (20%), Positives = 191/483 (39%), Gaps = 63/483 (13%)
Query: 11 LCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEI 70
L + L L V+T ++ + P + K L ++ +++ C + W +
Sbjct: 6 LLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWP- 64
Query: 71 LDETNENKQNEWITE-------------KAEATNTGKYTCTNKH-GLSNSIYVFVRDPAK 116
+ + ++Q +TE K +TG Y C + L++ IYV+V+D
Sbjct: 65 -NNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRS 123
Query: 117 LFLVDRS-----LYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPD------ 165
F+ S +Y E+ + V P ++N ++ C P + RF+PD
Sbjct: 124 PFIASVSDQHGVVYITENKNKTVVIPCLG-SISNLNVSLCARYP---EKRFVPDGNRISW 179
Query: 166 -PKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLR 224
K G I S +Y + + C +S S +I+ V ++ VV L
Sbjct: 180 DSKKGFTIPSYMISYAGM-VFCEAKINDESYQSIMYIVVV-VGYRIYDVVLSPSHGIELS 237
Query: 225 EGEEFTVTCTIK-DVSSSVYSTWKRENSQ---TKLQEKYNSWHHGDFNYERQATLTISSA 280
GE+ + CT + +++ + W+ +S+ KL + G + +TLTI
Sbjct: 238 VGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGV 297
Query: 281 RVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAF 340
+D G++ C A++ + +T + V +K F+ + + V GE V + +Y +
Sbjct: 298 TRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGY 357
Query: 341 PKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSN--SD 398
P PE +W +++ E+ I+ L + + + G YT +++N S
Sbjct: 358 PPPE-IKW----------YKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISK 406
Query: 399 VNAAIAFNVYVNTKPEI---------LTYDRLVNGMLQCVAAGFPEP-TIDWYFCPGTEQ 448
+ ++ V P+I +Y L C P P I WY+ E+
Sbjct: 407 EKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYW--QLEE 464
Query: 449 RCS 451
C+
Sbjct: 465 ECA 467
>gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [Homo
sapiens]
Length = 1363
Score = 342 bits (878), Expect = 8e-94
Identities = 198/506 (39%), Positives = 296/506 (58%), Gaps = 44/506 (8%)
Query: 426 LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKH 485
+QC+ AG P+I WY ++R VD+ N KL +Q + A
Sbjct: 697 MQCLVAGAHAPSIVWY----KDERLLEEKSGVDLADSNQ------KLSIQRVREEDA--- 743
Query: 486 NGTVECKAYNDVGKTSAYFNFAFKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQ 545
G C N G ++ + A + ++ +L+G ++A ++++++ + ++
Sbjct: 744 -GRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLI-FCNMR 801
Query: 546 KPMYEVQWKVVEEINGNNYVYIDPTQLPYDHK----------WEFPRNRLSFGKTLGAGA 595
+P + + G + +DP ++P + + WEFPR RL G+ LG GA
Sbjct: 802 RPAH------ADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGA 855
Query: 596 FGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGA 655
FGKVVEA+A+G+ K + TVAVKMLK A +E ALMSELK+L ++GNH+N+VNLLGA
Sbjct: 856 FGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGA 915
Query: 656 CT-IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDST 714
CT GP +VI E+C YG+L NFLR KRD+F ++ + ++ ++ E + D
Sbjct: 916 CTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMV---ELARLDRR 972
Query: 715 NEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAK 774
+ + T+ RR+ + ++P L +EDL+ +S+QVA+
Sbjct: 973 RPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSP---------LTMEDLVCYSFQVAR 1023
Query: 775 GMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAP 834
GM FLAS+ CIHRDLAARNILL+ + KICDFGLARDI D +YV KG+ARLP+KWMAP
Sbjct: 1024 GMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAP 1083
Query: 835 ESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAE 894
ESIF+ VYT +SDVWS+G+ LWE+FSLG+SPYPG+ ++ +F + +++G RM +PE A
Sbjct: 1084 ESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPA 1143
Query: 895 MYDIMKTCWDADPLKRPTFKQIVQLI 920
+ IM CW DP RP F ++V+++
Sbjct: 1144 IRRIMLNCWSGDPKARPAFSELVEIL 1169
Score = 79.3 bits (194), Expect = 2e-14
Identities = 109/479 (22%), Positives = 186/479 (38%), Gaps = 67/479 (13%)
Query: 14 LLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDE 73
L L L + G VS +PP+++ + ++ GD + + C ++W + E
Sbjct: 7 LCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQE 66
Query: 74 T----NENKQNEWITEKAEATN-----------------TGKYTCTNKH-------GLSN 105
+++ ++ + E T+ TG Y C K+ +
Sbjct: 67 APATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAA 126
Query: 106 SIYVFVRDPAKLFL--VDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFI 163
S YVFVRD + F+ D L ++D V C ++ P + N +L+ P +
Sbjct: 127 SSYVFVRDFEQPFINKPDTLLVNRKDA-MWVPCLVSIPGL-NVTLRSQSSVLWPDGQEVV 184
Query: 164 PDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLL 223
D + G+++ S + L L C + LS F++ + + + + + S L
Sbjct: 185 WDDRRGMLV-STPLLHDALYLQCETTWGDQDFLSNPFLVHIT-GNELYDIQLLPRKSLEL 242
Query: 224 REGEEFTVTCTI-KDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARV 282
GE+ + CT+ + +S V W Q + + + E + LTI +
Sbjct: 243 LVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQ 302
Query: 283 NDSGVFMCYANNTFGSANVTTTLEVVDKGFINI----FPMINTTVFVNDGENVDLIVEYE 338
+D G ++C ANN +T + V + FI++ P++ T E V L V+
Sbjct: 303 HDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATA---GDELVKLPVKLA 359
Query: 339 AFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNS- 397
A+P PE QW Y + S L L + GTYT + NS
Sbjct: 360 AYPPPEF-QW-------------YKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSA 405
Query: 398 -DVNAAIAFNVYVNTKPEI--------LTYDRLVNGMLQCVAAGFPEP-TIDWYFCPGT 446
+ I+ + VN P+I Y R L C A G P P +I W++ P T
Sbjct: 406 AGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWT 464
>gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [Homo
sapiens]
Length = 1298
Score = 342 bits (878), Expect = 8e-94
Identities = 198/506 (39%), Positives = 296/506 (58%), Gaps = 44/506 (8%)
Query: 426 LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKH 485
+QC+ AG P+I WY ++R VD+ N KL +Q + A
Sbjct: 697 MQCLVAGAHAPSIVWY----KDERLLEEKSGVDLADSNQ------KLSIQRVREEDA--- 743
Query: 486 NGTVECKAYNDVGKTSAYFNFAFKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQ 545
G C N G ++ + A + ++ +L+G ++A ++++++ + ++
Sbjct: 744 -GRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLI-FCNMR 801
Query: 546 KPMYEVQWKVVEEINGNNYVYIDPTQLPYDHK----------WEFPRNRLSFGKTLGAGA 595
+P + + G + +DP ++P + + WEFPR RL G+ LG GA
Sbjct: 802 RPAH------ADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGA 855
Query: 596 FGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGA 655
FGKVVEA+A+G+ K + TVAVKMLK A +E ALMSELK+L ++GNH+N+VNLLGA
Sbjct: 856 FGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGA 915
Query: 656 CT-IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDST 714
CT GP +VI E+C YG+L NFLR KRD+F ++ + ++ ++ E + D
Sbjct: 916 CTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMV---ELARLDRR 972
Query: 715 NEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAK 774
+ + T+ RR+ + ++P L +EDL+ +S+QVA+
Sbjct: 973 RPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSP---------LTMEDLVCYSFQVAR 1023
Query: 775 GMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAP 834
GM FLAS+ CIHRDLAARNILL+ + KICDFGLARDI D +YV KG+ARLP+KWMAP
Sbjct: 1024 GMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAP 1083
Query: 835 ESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAE 894
ESIF+ VYT +SDVWS+G+ LWE+FSLG+SPYPG+ ++ +F + +++G RM +PE A
Sbjct: 1084 ESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPA 1143
Query: 895 MYDIMKTCWDADPLKRPTFKQIVQLI 920
+ IM CW DP RP F ++V+++
Sbjct: 1144 IRRIMLNCWSGDPKARPAFSELVEIL 1169
Score = 79.3 bits (194), Expect = 2e-14
Identities = 109/479 (22%), Positives = 186/479 (38%), Gaps = 67/479 (13%)
Query: 14 LLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDE 73
L L L + G VS +PP+++ + ++ GD + + C ++W + E
Sbjct: 7 LCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQE 66
Query: 74 T----NENKQNEWITEKAEATN-----------------TGKYTCTNKH-------GLSN 105
+++ ++ + E T+ TG Y C K+ +
Sbjct: 67 APATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAA 126
Query: 106 SIYVFVRDPAKLFL--VDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFI 163
S YVFVRD + F+ D L ++D V C ++ P + N +L+ P +
Sbjct: 127 SSYVFVRDFEQPFINKPDTLLVNRKDA-MWVPCLVSIPGL-NVTLRSQSSVLWPDGQEVV 184
Query: 164 PDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLL 223
D + G+++ S + L L C + LS F++ + + + + + S L
Sbjct: 185 WDDRRGMLV-STPLLHDALYLQCETTWGDQDFLSNPFLVHIT-GNELYDIQLLPRKSLEL 242
Query: 224 REGEEFTVTCTI-KDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARV 282
GE+ + CT+ + +S V W Q + + + E + LTI +
Sbjct: 243 LVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQ 302
Query: 283 NDSGVFMCYANNTFGSANVTTTLEVVDKGFINI----FPMINTTVFVNDGENVDLIVEYE 338
+D G ++C ANN +T + V + FI++ P++ T E V L V+
Sbjct: 303 HDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATA---GDELVKLPVKLA 359
Query: 339 AFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNS- 397
A+P PE QW Y + S L L + GTYT + NS
Sbjct: 360 AYPPPEF-QW-------------YKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSA 405
Query: 398 -DVNAAIAFNVYVNTKPEI--------LTYDRLVNGMLQCVAAGFPEP-TIDWYFCPGT 446
+ I+ + VN P+I Y R L C A G P P +I W++ P T
Sbjct: 406 AGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWT 464
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 291 bits (744), Expect = 3e-78
Identities = 216/709 (30%), Positives = 336/709 (47%), Gaps = 132/709 (18%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVND----GE 329
+L + S +D G + C N +GS N T L+VV++ P++ + N G
Sbjct: 215 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHR--PILQAGLPANASTVVGG 272
Query: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGT 389
+V+ + + + +P H QWI K ++ +Y G +G
Sbjct: 273 DVEFVCKVYSDAQP-HIQWI--------------KHVEKNGSKY----------GPDGLP 307
Query: 390 YTFLVSNSDVNAAIA-----FNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCP 444
Y ++ +S +N++ A FNV T+ + Y V+ + + P
Sbjct: 308 YLKVLKHSGINSSNAEVLALFNV---TEADAGEYICKVSNYIGQANQSAWLTVLPKQQAP 364
Query: 445 GTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYF 504
G E+ +AS +++ G ++ + + + C+ N K
Sbjct: 365 GREKEITASPDYLEIAIYC-----IGVFLIACMVVT-------VILCRMKNTTKKP---- 408
Query: 505 NFAFKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNY 564
+F+ + +H T PL + A + P+ + ++ +
Sbjct: 409 DFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNS-------NTPLVRITTRLSSTADTPML 461
Query: 565 VYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLK 622
+ +LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK
Sbjct: 462 AGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK 521
Query: 623 PSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKR 682
A + L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 522 DDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR 581
Query: 683 DSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGS 742
PG+ Y S I
Sbjct: 582 P--------------------------------------PGMEY----------SYDINR 593
Query: 743 YIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRIT 802
E +T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T +
Sbjct: 594 VPEEQMT------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVM 641
Query: 803 KICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLG 862
KI DFGLARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG
Sbjct: 642 KIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLG 701
Query: 863 SSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEK 922
SPYPG+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++
Sbjct: 702 GSPYPGIPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 760
Query: 923 QISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 971
++ +TN Y +L+ +P+ +S S+ SS + D
Sbjct: 761 ILTLTTNEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 802
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 289 bits (739), Expect = 1e-77
Identities = 209/669 (31%), Positives = 322/669 (48%), Gaps = 125/669 (18%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVND----GE 329
+L + S +D G + C N +GS N T L+VV++ P++ + N G
Sbjct: 126 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHR--PILQAGLPANASTVVGG 183
Query: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGT 389
+V+ + + + +P H QWI K ++ +Y G +G
Sbjct: 184 DVEFVCKVYSDAQP-HIQWI--------------KHVEKNGSKY----------GPDGLP 218
Query: 390 YTFLVSNSDVNAAIA-----FNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCP 444
Y ++ +S +N++ A FNV T+ + Y V+ + + P
Sbjct: 219 YLKVLKHSGINSSNAEVLALFNV---TEADAGEYICKVSNYIGQANQSAWLTVLPKQQAP 275
Query: 445 GTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYF 504
G E+ +AS +++ G ++ + + + C+ N K
Sbjct: 276 GREKEITASPDYLEIAIYC-----IGVFLIACMVVT-------VILCRMKNTTKKP---- 319
Query: 505 NFAFKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNY 564
+F+ + +H T PL + A + P+ + ++ +
Sbjct: 320 DFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNS-------NTPLVRITTRLSSTADTPML 372
Query: 565 VYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLK 622
+ +LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK
Sbjct: 373 AGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK 432
Query: 623 PSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKR 682
A + L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 433 DDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR 492
Query: 683 DSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGS 742
PG+ Y S I
Sbjct: 493 P--------------------------------------PGMEY----------SYDINR 504
Query: 743 YIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRIT 802
E +T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T +
Sbjct: 505 VPEEQMT------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVM 552
Query: 803 KICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLG 862
KI DFGLARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG
Sbjct: 553 KIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLG 612
Query: 863 SSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEK 922
SPYPG+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++
Sbjct: 613 GSPYPGIPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 671
Query: 923 QISESTNHI 931
++ +TN I
Sbjct: 672 ILTLTTNEI 680
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 289 bits (739), Expect = 1e-77
Identities = 209/669 (31%), Positives = 322/669 (48%), Gaps = 125/669 (18%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVND----GE 329
+L + S +D G + C N +GS N T L+VV++ P++ + N G
Sbjct: 215 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHR--PILQAGLPANASTVVGG 272
Query: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGT 389
+V+ + + + +P H QWI K ++ +Y G +G
Sbjct: 273 DVEFVCKVYSDAQP-HIQWI--------------KHVEKNGSKY----------GPDGLP 307
Query: 390 YTFLVSNSDVNAAIA-----FNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCP 444
Y ++ +S +N++ A FNV T+ + Y V+ + + P
Sbjct: 308 YLKVLKHSGINSSNAEVLALFNV---TEADAGEYICKVSNYIGQANQSAWLTVLPKQQAP 364
Query: 445 GTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYF 504
G E+ +AS +++ G ++ + + + C+ N K
Sbjct: 365 GREKEITASPDYLEIAIYC-----IGVFLIACMVVT-------VILCRMKNTTKKP---- 408
Query: 505 NFAFKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNY 564
+F+ + +H T PL + A + P+ + ++ +
Sbjct: 409 DFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNS-------NTPLVRITTRLSSTADTPML 461
Query: 565 VYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLK 622
+ +LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK
Sbjct: 462 AGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK 521
Query: 623 PSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKR 682
A + L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 522 DDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR 581
Query: 683 DSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGS 742
PG+ Y S I
Sbjct: 582 P--------------------------------------PGMEY----------SYDINR 593
Query: 743 YIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRIT 802
E +T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T +
Sbjct: 594 VPEEQMT------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVM 641
Query: 803 KICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLG 862
KI DFGLARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG
Sbjct: 642 KIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLG 701
Query: 863 SSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEK 922
SPYPG+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++
Sbjct: 702 GSPYPGIPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 760
Query: 923 QISESTNHI 931
++ +TN I
Sbjct: 761 ILTLTTNEI 769
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 289 bits (739), Expect = 1e-77
Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)
Query: 571 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 628
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 350 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 409
Query: 629 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 688
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 410 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 464
Query: 689 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 748
PG+ Y S I E +
Sbjct: 465 ---------------------------------PGMEY----------SYDINRVPEEQM 481
Query: 749 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 808
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 482 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 529
Query: 809 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 868
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 530 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 589
Query: 869 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 928
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 590 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 648
Query: 929 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 971
N Y +L+ +P+ +S S+ SS + D
Sbjct: 649 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 684
Score = 31.6 bits (70), Expect = 3.8
Identities = 32/136 (23%), Positives = 60/136 (44%), Gaps = 15/136 (11%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
+L + S +D G + C N +GS N T L+VV++ + N + V G
Sbjct: 100 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV--GG 157
Query: 330 NVDLIVEYEAFPKPEHQQWI-YMNRTFTDKWED---YPKSENESNI----RYVSELHLTR 381
+V+ + + + +P H QWI ++ + + D Y K + + + + L++
Sbjct: 158 DVEFVCKVYSDAQP-HIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 216
Query: 382 LKGTEGGTYTFLVSNS 397
+ + G YT L NS
Sbjct: 217 VTFEDAGEYTCLAGNS 232
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 289 bits (739), Expect = 1e-77
Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)
Query: 571 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 628
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 351 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 410
Query: 629 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 688
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 411 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 465
Query: 689 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 748
PG+ Y S I E +
Sbjct: 466 ---------------------------------PGMEY----------SYDINRVPEEQM 482
Query: 749 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 808
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 483 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 530
Query: 809 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 868
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 531 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 590
Query: 869 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 928
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 591 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 649
Query: 929 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 971
N Y +L+ +P+ +S S+ SS + D
Sbjct: 650 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 685
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 289 bits (739), Expect = 1e-77
Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)
Query: 571 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 628
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 352 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 411
Query: 629 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 688
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 412 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 466
Query: 689 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 748
PG+ Y S I E +
Sbjct: 467 ---------------------------------PGMEY----------SYDINRVPEEQM 483
Query: 749 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 808
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 484 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 531
Query: 809 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 868
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 532 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 591
Query: 869 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 928
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 592 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 650
Query: 929 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 971
N Y +L+ +P+ +S S+ SS + D
Sbjct: 651 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 686
Score = 31.6 bits (70), Expect = 3.8
Identities = 32/136 (23%), Positives = 60/136 (44%), Gaps = 15/136 (11%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
+L + S +D G + C N +GS N T L+VV++ + N + V G
Sbjct: 100 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV--GG 157
Query: 330 NVDLIVEYEAFPKPEHQQWI-YMNRTFTDKWED---YPKSENESNI----RYVSELHLTR 381
+V+ + + + +P H QWI ++ + + D Y K + + + + L++
Sbjct: 158 DVEFVCKVYSDAQP-HIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 216
Query: 382 LKGTEGGTYTFLVSNS 397
+ + G YT L NS
Sbjct: 217 VTFEDAGEYTCLAGNS 232
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 289 bits (739), Expect = 1e-77
Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)
Query: 571 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 628
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 355 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 414
Query: 629 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 688
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 415 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 469
Query: 689 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 748
PG+ Y S I E +
Sbjct: 470 ---------------------------------PGMEY----------SYDINRVPEEQM 486
Query: 749 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 808
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 487 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 534
Query: 809 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 868
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 535 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 594
Query: 869 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 928
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 595 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 653
Query: 929 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 971
N Y +L+ +P+ +S S+ SS + D
Sbjct: 654 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 689
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 289 bits (739), Expect = 1e-77
Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)
Query: 571 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 628
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 467 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 526
Query: 629 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 688
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 527 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 581
Query: 689 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 748
PG+ Y S I E +
Sbjct: 582 ---------------------------------PGMEY----------SYDINRVPEEQM 598
Query: 749 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 808
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 599 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 646
Query: 809 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 868
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 647 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 706
Query: 869 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 928
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 707 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 765
Query: 929 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 971
N Y +L+ +P+ +S S+ SS + D
Sbjct: 766 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 801
Score = 31.6 bits (70), Expect = 3.8
Identities = 32/136 (23%), Positives = 60/136 (44%), Gaps = 15/136 (11%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
+L + S +D G + C N +GS N T L+VV++ + N + V G
Sbjct: 215 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV--GG 272
Query: 330 NVDLIVEYEAFPKPEHQQWI-YMNRTFTDKWED---YPKSENESNI----RYVSELHLTR 381
+V+ + + + +P H QWI ++ + + D Y K + + + + L++
Sbjct: 273 DVEFVCKVYSDAQP-HIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 331
Query: 382 LKGTEGGTYTFLVSNS 397
+ + G YT L NS
Sbjct: 332 VTFEDAGEYTCLAGNS 347
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 287 bits (734), Expect = 4e-77
Identities = 158/378 (41%), Positives = 217/378 (57%), Gaps = 63/378 (16%)
Query: 561 GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAA--MTVAV 618
G + +LP D KWE R RL+ GK LG G FG+VV A A G+ K AA +TVAV
Sbjct: 450 GPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV 509
Query: 619 KMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFL 678
KMLK A + L+SE++++ +G H NI+NLLGACT GGP V+ EY G+L FL
Sbjct: 510 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 569
Query: 679 RRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSV 738
R +R PG+ Y T
Sbjct: 570 RARRP--------------------------------------PGLDYSFDT-------- 583
Query: 739 RIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH 798
+ E L +DL+S +YQVA+GM +LAS+ CIHRDLAARN+L+T
Sbjct: 584 --------------CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE 629
Query: 799 GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWEL 858
+ KI DFGLARD+ N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ LWE+
Sbjct: 630 DNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI 689
Query: 859 FSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 918
F+LG SPYPG+PV+ + +K++KEG RM P + ++Y IM+ CW A P +RPTFKQ+V+
Sbjct: 690 FTLGGSPYPGIPVE-ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVE 748
Query: 919 LIEKQISESTNHIYSNLA 936
+++ ++ ++ Y +L+
Sbjct: 749 DLDRVLTVTSTDEYLDLS 766
Score = 30.8 bits (68), Expect = 6.4
Identities = 14/40 (35%), Positives = 23/40 (57%)
Query: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDK 310
+Q +L + S +D G + C N FGS T TL+V+++
Sbjct: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLER 248
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 287 bits (734), Expect = 4e-77
Identities = 158/378 (41%), Positives = 217/378 (57%), Gaps = 63/378 (16%)
Query: 561 GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAA--MTVAV 618
G + +LP D KWE R RL+ GK LG G FG+VV A A G+ K AA +TVAV
Sbjct: 336 GPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV 395
Query: 619 KMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFL 678
KMLK A + L+SE++++ +G H NI+NLLGACT GGP V+ EY G+L FL
Sbjct: 396 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 455
Query: 679 RRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSV 738
R +R PG+ Y T
Sbjct: 456 RARRP--------------------------------------PGLDYSFDT-------- 469
Query: 739 RIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH 798
+ E L +DL+S +YQVA+GM +LAS+ CIHRDLAARN+L+T
Sbjct: 470 --------------CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE 515
Query: 799 GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWEL 858
+ KI DFGLARD+ N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ LWE+
Sbjct: 516 DNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI 575
Query: 859 FSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 918
F+LG SPYPG+PV+ + +K++KEG RM P + ++Y IM+ CW A P +RPTFKQ+V+
Sbjct: 576 FTLGGSPYPGIPVE-ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVE 634
Query: 919 LIEKQISESTNHIYSNLA 936
+++ ++ ++ Y +L+
Sbjct: 635 DLDRVLTVTSTDEYLDLS 652
Score = 30.8 bits (68), Expect = 6.4
Identities = 14/40 (35%), Positives = 23/40 (57%)
Query: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDK 310
+Q +L + S +D G + C N FGS T TL+V+++
Sbjct: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLER 248
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 287 bits (734), Expect = 4e-77
Identities = 158/378 (41%), Positives = 217/378 (57%), Gaps = 63/378 (16%)
Query: 561 GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAA--MTVAV 618
G + +LP D KWE R RL+ GK LG G FG+VV A A G+ K AA +TVAV
Sbjct: 448 GPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV 507
Query: 619 KMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFL 678
KMLK A + L+SE++++ +G H NI+NLLGACT GGP V+ EY G+L FL
Sbjct: 508 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 567
Query: 679 RRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSV 738
R +R PG+ Y T
Sbjct: 568 RARRP--------------------------------------PGLDYSFDT-------- 581
Query: 739 RIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH 798
+ E L +DL+S +YQVA+GM +LAS+ CIHRDLAARN+L+T
Sbjct: 582 --------------CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE 627
Query: 799 GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWEL 858
+ KI DFGLARD+ N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ LWE+
Sbjct: 628 DNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI 687
Query: 859 FSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 918
F+LG SPYPG+PV+ + +K++KEG RM P + ++Y IM+ CW A P +RPTFKQ+V+
Sbjct: 688 FTLGGSPYPGIPVE-ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVE 746
Query: 919 LIEKQISESTNHIYSNLA 936
+++ ++ ++ Y +L+
Sbjct: 747 DLDRVLTVTSTDEYLDLS 764
Score = 30.8 bits (68), Expect = 6.4
Identities = 14/40 (35%), Positives = 23/40 (57%)
Query: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDK 310
+Q +L + S +D G + C N FGS T TL+V+++
Sbjct: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLER 248
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 285 bits (730), Expect = 1e-76
Identities = 156/361 (43%), Positives = 214/361 (59%), Gaps = 63/361 (17%)
Query: 571 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 628
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 378 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 437
Query: 629 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 688
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 438 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 492
Query: 689 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 748
PG+ Y S I E +
Sbjct: 493 ---------------------------------PGMEY----------SYDINRVPEEQM 509
Query: 749 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 808
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 510 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 557
Query: 809 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 868
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 558 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 617
Query: 869 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 928
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 618 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 676
Query: 929 N 929
N
Sbjct: 677 N 677
Score = 31.6 bits (70), Expect = 3.8
Identities = 32/136 (23%), Positives = 60/136 (44%), Gaps = 15/136 (11%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
+L + S +D G + C N +GS N T L+VV++ + N + V G
Sbjct: 126 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV--GG 183
Query: 330 NVDLIVEYEAFPKPEHQQWI-YMNRTFTDKWED---YPKSENESNI----RYVSELHLTR 381
+V+ + + + +P H QWI ++ + + D Y K + + + + L++
Sbjct: 184 DVEFVCKVYSDAQP-HIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 242
Query: 382 LKGTEGGTYTFLVSNS 397
+ + G YT L NS
Sbjct: 243 VTFEDAGEYTCLAGNS 258
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 269 bits (688), Expect = 8e-72
Identities = 212/688 (30%), Positives = 321/688 (46%), Gaps = 156/688 (22%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
++ + S +D G + C N +GS N T L+VV++ + N TV + G
Sbjct: 123 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL--GS 180
Query: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKW--EDYP------KSENESNIRYVSELHLTR 381
NV+ + + + P+P H QW+ K ++ P + + + + LHL
Sbjct: 181 NVEFMCKVYSDPQP-HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 239
Query: 382 LKGTEGGTYTFLVSN----SDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPE-- 435
+ + G YT L N S +A + + +P ++T + ++ C A
Sbjct: 240 VSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCM 299
Query: 436 --PTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKA 493
I + GT++ S + V L S P ++ V S DSSA ++G +
Sbjct: 300 VGSVIVYKMKSGTKKSDFHSQMA--VHKLAKSIPLRRQVTV--SADSSASMNSGVL---- 351
Query: 494 YNDVGKTSAYFNFAFKEQIHPHTLF---TPLLIGFVIVAGMMCIIVMILTYKYLQKPMYE 550
+ P L TP+L G + Y+ + P +E
Sbjct: 352 -----------------LVRPSRLSSSGTPMLAG-------------VSEYELPEDPRWE 381
Query: 551 VQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKS 610
LP D RL GK LG G FG+VV A A GL K
Sbjct: 382 ---------------------LPRD--------RLVLGKPLGEGCFGQVVLAEAIGLDKD 412
Query: 611 --DAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEY 668
+ VAVKMLK A + L+SE++++ +G H NI+NLLGACT GP VI EY
Sbjct: 413 KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 472
Query: 669 CCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVV 728
G+L +L+ +R PG+ Y
Sbjct: 473 ASKGNLREYLQARR--------------------------------------PPGLEYC- 493
Query: 729 PTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRD 788
P+ +++L+ +DL+S +YQVA+GM +LASK CIHRD
Sbjct: 494 -------------------YNPSHNPEEQLS--SKDLVSCAYQVARGMEYLASKKCIHRD 532
Query: 789 LAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDV 848
LAARN+L+T + KI DFGLARDI + Y N RLPVKWMAPE++F+ +YT +SDV
Sbjct: 533 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV 592
Query: 849 WSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPL 908
WS+G+ LWE+F+LG SPYPG+PV+ + +K++KEG RM P + E+Y +M+ CW A P
Sbjct: 593 WSFGVLLWEIFTLGGSPYPGVPVE-ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPS 651
Query: 909 KRPTFKQIVQLIEKQISESTNHIYSNLA 936
+RPTFKQ+V+ +++ ++ ++N Y +L+
Sbjct: 652 QRPTFKQLVEDLDRIVALTSNQEYLDLS 679
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 269 bits (688), Expect = 8e-72
Identities = 212/688 (30%), Positives = 321/688 (46%), Gaps = 156/688 (22%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
++ + S +D G + C N +GS N T L+VV++ + N TV + G
Sbjct: 125 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL--GS 182
Query: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKW--EDYP------KSENESNIRYVSELHLTR 381
NV+ + + + P+P H QW+ K ++ P + + + + LHL
Sbjct: 183 NVEFMCKVYSDPQP-HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 241
Query: 382 LKGTEGGTYTFLVSN----SDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPE-- 435
+ + G YT L N S +A + + +P ++T + ++ C A
Sbjct: 242 VSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCM 301
Query: 436 --PTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKA 493
I + GT++ S + V L S P ++ V S DSSA ++G +
Sbjct: 302 VGSVIVYKMKSGTKKSDFHSQMA--VHKLAKSIPLRRQVTV--SADSSASMNSGVL---- 353
Query: 494 YNDVGKTSAYFNFAFKEQIHPHTLF---TPLLIGFVIVAGMMCIIVMILTYKYLQKPMYE 550
+ P L TP+L G + Y+ + P +E
Sbjct: 354 -----------------LVRPSRLSSSGTPMLAG-------------VSEYELPEDPRWE 383
Query: 551 VQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKS 610
LP D RL GK LG G FG+VV A A GL K
Sbjct: 384 ---------------------LPRD--------RLVLGKPLGEGCFGQVVLAEAIGLDKD 414
Query: 611 --DAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEY 668
+ VAVKMLK A + L+SE++++ +G H NI+NLLGACT GP VI EY
Sbjct: 415 KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 474
Query: 669 CCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVV 728
G+L +L+ +R PG+ Y
Sbjct: 475 ASKGNLREYLQARR--------------------------------------PPGLEYC- 495
Query: 729 PTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRD 788
P+ +++L+ +DL+S +YQVA+GM +LASK CIHRD
Sbjct: 496 -------------------YNPSHNPEEQLS--SKDLVSCAYQVARGMEYLASKKCIHRD 534
Query: 789 LAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDV 848
LAARN+L+T + KI DFGLARDI + Y N RLPVKWMAPE++F+ +YT +SDV
Sbjct: 535 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV 594
Query: 849 WSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPL 908
WS+G+ LWE+F+LG SPYPG+PV+ + +K++KEG RM P + E+Y +M+ CW A P
Sbjct: 595 WSFGVLLWEIFTLGGSPYPGVPVE-ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPS 653
Query: 909 KRPTFKQIVQLIEKQISESTNHIYSNLA 936
+RPTFKQ+V+ +++ ++ ++N Y +L+
Sbjct: 654 QRPTFKQLVEDLDRIVALTSNQEYLDLS 681
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 269 bits (688), Expect = 8e-72
Identities = 212/688 (30%), Positives = 321/688 (46%), Gaps = 156/688 (22%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
++ + S +D G + C N +GS N T L+VV++ + N TV + G
Sbjct: 212 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL--GS 269
Query: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKW--EDYP------KSENESNIRYVSELHLTR 381
NV+ + + + P+P H QW+ K ++ P + + + + LHL
Sbjct: 270 NVEFMCKVYSDPQP-HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 328
Query: 382 LKGTEGGTYTFLVSN----SDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPE-- 435
+ + G YT L N S +A + + +P ++T + ++ C A
Sbjct: 329 VSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCM 388
Query: 436 --PTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKA 493
I + GT++ S + V L S P ++ V S DSSA ++G +
Sbjct: 389 VGSVIVYKMKSGTKKSDFHSQMA--VHKLAKSIPLRRQVTV--SADSSASMNSGVL---- 440
Query: 494 YNDVGKTSAYFNFAFKEQIHPHTLF---TPLLIGFVIVAGMMCIIVMILTYKYLQKPMYE 550
+ P L TP+L G + Y+ + P +E
Sbjct: 441 -----------------LVRPSRLSSSGTPMLAG-------------VSEYELPEDPRWE 470
Query: 551 VQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKS 610
LP D RL GK LG G FG+VV A A GL K
Sbjct: 471 ---------------------LPRD--------RLVLGKPLGEGCFGQVVLAEAIGLDKD 501
Query: 611 --DAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEY 668
+ VAVKMLK A + L+SE++++ +G H NI+NLLGACT GP VI EY
Sbjct: 502 KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 561
Query: 669 CCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVV 728
G+L +L+ +R PG+ Y
Sbjct: 562 ASKGNLREYLQARR--------------------------------------PPGLEYC- 582
Query: 729 PTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRD 788
P+ +++L+ +DL+S +YQVA+GM +LASK CIHRD
Sbjct: 583 -------------------YNPSHNPEEQLS--SKDLVSCAYQVARGMEYLASKKCIHRD 621
Query: 789 LAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDV 848
LAARN+L+T + KI DFGLARDI + Y N RLPVKWMAPE++F+ +YT +SDV
Sbjct: 622 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV 681
Query: 849 WSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPL 908
WS+G+ LWE+F+LG SPYPG+PV+ + +K++KEG RM P + E+Y +M+ CW A P
Sbjct: 682 WSFGVLLWEIFTLGGSPYPGVPVE-ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPS 740
Query: 909 KRPTFKQIVQLIEKQISESTNHIYSNLA 936
+RPTFKQ+V+ +++ ++ ++N Y +L+
Sbjct: 741 QRPTFKQLVEDLDRIVALTSNQEYLDLS 768
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 269 bits (688), Expect = 8e-72
Identities = 212/688 (30%), Positives = 321/688 (46%), Gaps = 156/688 (22%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
++ + S +D G + C N +GS N T L+VV++ + N TV + G
Sbjct: 214 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL--GS 271
Query: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKW--EDYP------KSENESNIRYVSELHLTR 381
NV+ + + + P+P H QW+ K ++ P + + + + LHL
Sbjct: 272 NVEFMCKVYSDPQP-HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 330
Query: 382 LKGTEGGTYTFLVSN----SDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPE-- 435
+ + G YT L N S +A + + +P ++T + ++ C A
Sbjct: 331 VSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCM 390
Query: 436 --PTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKA 493
I + GT++ S + V L S P ++ V S DSSA ++G +
Sbjct: 391 VGSVIVYKMKSGTKKSDFHSQMA--VHKLAKSIPLRRQVTV--SADSSASMNSGVL---- 442
Query: 494 YNDVGKTSAYFNFAFKEQIHPHTLF---TPLLIGFVIVAGMMCIIVMILTYKYLQKPMYE 550
+ P L TP+L G + Y+ + P +E
Sbjct: 443 -----------------LVRPSRLSSSGTPMLAG-------------VSEYELPEDPRWE 472
Query: 551 VQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKS 610
LP D RL GK LG G FG+VV A A GL K
Sbjct: 473 ---------------------LPRD--------RLVLGKPLGEGCFGQVVLAEAIGLDKD 503
Query: 611 --DAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEY 668
+ VAVKMLK A + L+SE++++ +G H NI+NLLGACT GP VI EY
Sbjct: 504 KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 563
Query: 669 CCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVV 728
G+L +L+ +R PG+ Y
Sbjct: 564 ASKGNLREYLQARR--------------------------------------PPGLEYC- 584
Query: 729 PTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRD 788
P+ +++L+ +DL+S +YQVA+GM +LASK CIHRD
Sbjct: 585 -------------------YNPSHNPEEQLS--SKDLVSCAYQVARGMEYLASKKCIHRD 623
Query: 789 LAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDV 848
LAARN+L+T + KI DFGLARDI + Y N RLPVKWMAPE++F+ +YT +SDV
Sbjct: 624 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV 683
Query: 849 WSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPL 908
WS+G+ LWE+F+LG SPYPG+PV+ + +K++KEG RM P + E+Y +M+ CW A P
Sbjct: 684 WSFGVLLWEIFTLGGSPYPGVPVE-ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPS 742
Query: 909 KRPTFKQIVQLIEKQISESTNHIYSNLA 936
+RPTFKQ+V+ +++ ++ ++N Y +L+
Sbjct: 743 QRPTFKQLVEDLDRIVALTSNQEYLDLS 770
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 265 bits (678), Expect = 1e-70
Identities = 152/379 (40%), Positives = 214/379 (56%), Gaps = 56/379 (14%)
Query: 563 NYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK 622
N V +D ++ D KWEFPR L GKTLG G FGKVV+ATA+ L TVAVKMLK
Sbjct: 702 NQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK 761
Query: 623 PSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKR 682
+A +E L+SE VL + NH +++ L GAC+ GP L+I EY YG L FLR R
Sbjct: 762 ENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR 820
Query: 683 DSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGS 742
K G Y +GS
Sbjct: 821 --------------------------------------KVGPGY-------------LGS 829
Query: 743 YIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRIT 802
R+ + ++ DE AL + DL+SF++Q+++GM +LA +HRDLAARNIL+ GR
Sbjct: 830 GGSRN-SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKM 888
Query: 803 KICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLG 862
KI DFGL+RD+ + +YV + R+PVKWMA ES+F+ +YT +SDVWS+G+ LWE+ +LG
Sbjct: 889 KISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLG 948
Query: 863 SSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEK 922
+PYPG+P + + + ++K G RM P++ EMY +M CW +P KRP F I + +EK
Sbjct: 949 GNPYPGIPPE-RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEK 1007
Query: 923 QISESTNHIYSNLANCSPN 941
+ + + Y +LA +P+
Sbjct: 1008 MMVKRRD--YLDLAASTPS 1024
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 265 bits (678), Expect = 1e-70
Identities = 152/379 (40%), Positives = 214/379 (56%), Gaps = 56/379 (14%)
Query: 563 NYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK 622
N V +D ++ D KWEFPR L GKTLG G FGKVV+ATA+ L TVAVKMLK
Sbjct: 702 NQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK 761
Query: 623 PSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKR 682
+A +E L+SE VL + NH +++ L GAC+ GP L+I EY YG L FLR R
Sbjct: 762 ENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR 820
Query: 683 DSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGS 742
K G Y +GS
Sbjct: 821 --------------------------------------KVGPGY-------------LGS 829
Query: 743 YIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRIT 802
R+ + ++ DE AL + DL+SF++Q+++GM +LA +HRDLAARNIL+ GR
Sbjct: 830 GGSRN-SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKM 888
Query: 803 KICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLG 862
KI DFGL+RD+ + +YV + R+PVKWMA ES+F+ +YT +SDVWS+G+ LWE+ +LG
Sbjct: 889 KISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLG 948
Query: 863 SSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEK 922
+PYPG+P + + + ++K G RM P++ EMY +M CW +P KRP F I + +EK
Sbjct: 949 GNPYPGIPPE-RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEK 1007
Query: 923 QISESTNHIYSNLANCSPN 941
+ + + Y +LA +P+
Sbjct: 1008 MMVKRRD--YLDLAASTPS 1024
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,177,072
Number of Sequences: 37866
Number of extensions: 1769392
Number of successful extensions: 8439
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 573
Number of HSP's successfully gapped in prelim test: 334
Number of HSP's that attempted gapping in prelim test: 4752
Number of HSP's gapped (non-prelim): 2744
length of query: 972
length of database: 18,247,518
effective HSP length: 112
effective length of query: 860
effective length of database: 14,006,526
effective search space: 12045612360
effective search space used: 12045612360
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.