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Search of human proteins with 145611446
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|145611446 tumor protein p53 inducible protein 5 [Homo
sapiens]
(782 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|145611446 tumor protein p53 inducible protein 5 [Homo sapiens] 1588 0.0
gi|218084958 anoctamin 4 [Homo sapiens] 560 e-159
gi|156766084 transmembrane protein 16C [Homo sapiens] 525 e-149
gi|218081589 anoctamin 5 isoform b [Homo sapiens] 437 e-122
gi|47106048 anoctamin 5 isoform a [Homo sapiens] 437 e-122
gi|218156303 anoctamin 6 isoform b [Homo sapiens] 424 e-118
gi|218156299 anoctamin 6 isoform a [Homo sapiens] 424 e-118
gi|194306539 anoctamin 1, calcium activated chloride channel [Ho... 416 e-116
gi|209862785 anoctamin 2 [Homo sapiens] 411 e-114
gi|218156307 anoctamin 6 isoform c [Homo sapiens] 405 e-113
gi|218156305 anoctamin 6 isoform c [Homo sapiens] 405 e-113
gi|145207958 transmembrane protein 16G isoform NGEP long [Homo s... 379 e-105
gi|94536803 transmembrane protein 16K [Homo sapiens] 157 3e-38
gi|55741655 anoctamin 8 [Homo sapiens] 90 7e-18
gi|239747244 PREDICTED: hypothetical protein [Homo sapiens] 63 9e-10
gi|239741065 PREDICTED: hypothetical protein [Homo sapiens] 62 3e-09
gi|169161033 PREDICTED: hypothetical protein [Homo sapiens] 56 1e-07
gi|21071070 transmembrane channel-like 1 [Homo sapiens] 31 3.9
gi|94536852 transmembrane cochlear-expressed protein 2 [Homo sap... 31 5.1
gi|119943102 CREB binding protein isoform b [Homo sapiens] 30 8.6
gi|119943104 CREB binding protein isoform a [Homo sapiens] 30 8.6
>gi|145611446 tumor protein p53 inducible protein 5 [Homo sapiens]
Length = 782
Score = 1588 bits (4113), Expect = 0.0
Identities = 782/782 (100%), Positives = 782/782 (100%)
Query: 1 MQGEESLRILVEPEGDSFPLMEISTCETEASEQWDYVLVAQRHTQRDPRQARQQQFLEEL 60
MQGEESLRILVEPEGDSFPLMEISTCETEASEQWDYVLVAQRHTQRDPRQARQQQFLEEL
Sbjct: 1 MQGEESLRILVEPEGDSFPLMEISTCETEASEQWDYVLVAQRHTQRDPRQARQQQFLEEL 60
Query: 61 RRKGFHIKVIRDQKQVFFGIRADNSVFGLYRTLLLEPEGPAPHAELAAPTTIPVTTSLRI 120
RRKGFHIKVIRDQKQVFFGIRADNSVFGLYRTLLLEPEGPAPHAELAAPTTIPVTTSLRI
Sbjct: 61 RRKGFHIKVIRDQKQVFFGIRADNSVFGLYRTLLLEPEGPAPHAELAAPTTIPVTTSLRI 120
Query: 121 RIVNFVVMNNKTSAGETFEDLMKDGVFEARFPLHKGEGRLKKTWARWRHMFREQPVDEIR 180
RIVNFVVMNNKTSAGETFEDLMKDGVFEARFPLHKGEGRLKKTWARWRHMFREQPVDEIR
Sbjct: 121 RIVNFVVMNNKTSAGETFEDLMKDGVFEARFPLHKGEGRLKKTWARWRHMFREQPVDEIR 180
Query: 181 NYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEICEAHDILMCPLG 240
NYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEICEAHDILMCPLG
Sbjct: 181 NYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEICEAHDILMCPLG 240
Query: 241 DHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHWDLYV 300
DHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHWDLYV
Sbjct: 241 DHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHWDLYV 300
Query: 301 WDEEQEEMALQLINCPDYKLRPYQHSYLRSTVILVLTLLMICLMIGMAHVLVVYRVLASA 360
WDEEQEEMALQLINCPDYKLRPYQHSYLRSTVILVLTLLMICLMIGMAHVLVVYRVLASA
Sbjct: 301 WDEEQEEMALQLINCPDYKLRPYQHSYLRSTVILVLTLLMICLMIGMAHVLVVYRVLASA 360
Query: 361 LFSSSAVPFLEEQVTTAVVVTGALVHYVTIIIMTKINRCVALKLCDFEMPRTFSERESRF 420
LFSSSAVPFLEEQVTTAVVVTGALVHYVTIIIMTKINRCVALKLCDFEMPRTFSERESRF
Sbjct: 361 LFSSSAVPFLEEQVTTAVVVTGALVHYVTIIIMTKINRCVALKLCDFEMPRTFSERESRF 420
Query: 421 TIRFFTLQFFTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAI 480
TIRFFTLQFFTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAI
Sbjct: 421 TIRFFTLQFFTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAI 480
Query: 481 IMGLKQTLSNCVEYLVPWVTHKCRSLRASESGHLPRDPELRDWRRNYLLNPVNTFSLFDE 540
IMGLKQTLSNCVEYLVPWVTHKCRSLRASESGHLPRDPELRDWRRNYLLNPVNTFSLFDE
Sbjct: 481 IMGLKQTLSNCVEYLVPWVTHKCRSLRASESGHLPRDPELRDWRRNYLLNPVNTFSLFDE 540
Query: 541 FMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQ 600
FMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQ
Sbjct: 541 FMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQ 600
Query: 601 VLETIGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHT 660
VLETIGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHT
Sbjct: 601 VLETIGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHT 660
Query: 661 KDFQDPDGIEGSENVTLCRYRDYRNPPDYNFSEQFWFLLAIRLAFVILFEHVALCIKLIA 720
KDFQDPDGIEGSENVTLCRYRDYRNPPDYNFSEQFWFLLAIRLAFVILFEHVALCIKLIA
Sbjct: 661 KDFQDPDGIEGSENVTLCRYRDYRNPPDYNFSEQFWFLLAIRLAFVILFEHVALCIKLIA 720
Query: 721 AWFVPDIPQSVKNKVLEVKYQRLREKMWHGRQRLGGVGAGSRPPMPAHPTPASIFSARST 780
AWFVPDIPQSVKNKVLEVKYQRLREKMWHGRQRLGGVGAGSRPPMPAHPTPASIFSARST
Sbjct: 721 AWFVPDIPQSVKNKVLEVKYQRLREKMWHGRQRLGGVGAGSRPPMPAHPTPASIFSARST 780
Query: 781 DV 782
DV
Sbjct: 781 DV 782
>gi|218084958 anoctamin 4 [Homo sapiens]
Length = 920
Score = 560 bits (1444), Expect = e-159
Identities = 297/668 (44%), Positives = 405/668 (60%), Gaps = 51/668 (7%)
Query: 119 RIRIVNFVVMNNKTSAGET---FEDLMKDGVFEARFPLHKGEGRLKKT------------ 163
R RIV+ ++ K G+ L+ +G +EA FPLH+G R K +
Sbjct: 225 RSRIVHHILQRIKYEEGKNKIGLNRLLTNGSYEAAFPLHEGSYRSKNSIRTHGAENHRHL 284
Query: 164 ----WARWRHMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLF 219
WA W ++ QP+D +R YFGEK+ LYF WLGWYT ML PAA GL VFL G +
Sbjct: 285 LYECWASWGVWYKYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVTTL 344
Query: 220 EASQISKEICEAHDILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWAT 279
+ SQ+SKE+C+A DI+MCP+ D + RLS++C +AK+THLFDN TV FA+FMA+WAT
Sbjct: 345 DHSQVSKEVCQATDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWAT 404
Query: 280 VFLEIWKRQRARVVLHWDLYVWDEEQEEMALQL---------INCPDYKLRPYQHSYLRS 330
VFLE WKR+RA + WDL W+EE+EE+ Q +N K PYQ +
Sbjct: 405 VFLEFWKRRRAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKERMNPISGKPEPYQAFTDKC 464
Query: 331 TVILVLT---LLMICLMIGMAHVLVVYRVLASALFSSSAVPFLEEQVTTAVVVTGALVHY 387
+ ++V MIC++I +V+YRV+ + F++ + A T +++
Sbjct: 465 SRLIVSASGIFFMICVVIAAVFGIVIYRVVTVSTFAAFKWALIRNNSQVATTGTAVCINF 524
Query: 388 VTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRIN 447
I+++ + VAL L + E PRT SE E+ FT++ F QF SS YIAF LGR
Sbjct: 525 CIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFT 584
Query: 448 GHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVP-----WVTHK 502
GHPG RL W+LEECH SGC++DL +QM IIM LKQT +N +E P W K
Sbjct: 585 GHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRK 644
Query: 503 CRSLRASESGHLPRDPELRDWRRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAP 562
R E R W ++Y L P+N + LFDE++EM++Q+GFTTIFVAAFPLAP
Sbjct: 645 VRQEHGPE-----RKISFPQWEKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAP 699
Query: 563 LLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSE 622
LLAL +N++EIRLDA K V RR + +AKDIG W +LE IG+L+VI N VIA TS+
Sbjct: 700 LLALLNNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITSD 759
Query: 623 FIPRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQ-----DPDGIEGSEN-VT 676
FIPR+VY Y+Y PC +G + C+ GYVN SLSVF DF+ + DG E S +
Sbjct: 760 FIPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSEPESDGSEFSGTPLK 819
Query: 677 LCRYRDYRNPP----DYNFSEQFWFLLAIRLAFVILFEHVALCIKLIAAWFVPDIPQSVK 732
CRYRDYR+PP Y ++ QFW +LA RLAF+I+FEH+ CIK + ++ +PD+P+ ++
Sbjct: 820 YCRYRDYRDPPHSLVPYGYTLQFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDLR 879
Query: 733 NKVLEVKY 740
+++ KY
Sbjct: 880 DRMRREKY 887
>gi|156766084 transmembrane protein 16C [Homo sapiens]
Length = 981
Score = 525 bits (1353), Expect = e-149
Identities = 284/666 (42%), Positives = 396/666 (59%), Gaps = 55/666 (8%)
Query: 115 TTSLRIRIVNFVVMNNKTSAGET---FEDLMKDGVFEARFPLHKGEGR------------ 159
+ + R RIV ++ K G + L+ +G + A FP H+G +
Sbjct: 301 SNATRSRIVYHMLERTKYENGISKVGIRKLINNGSYIAAFPPHEGAYKSSQPIKTHGPQN 360
Query: 160 ----LKKTWARWRHMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSG 215
L + WARW ++ QP+D IR YFGEK+ LYF WLGWYT ML+PAA+ GL VF G
Sbjct: 361 NRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYG 420
Query: 216 FSLFEASQISKEICEAHDILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMA 275
SQ+S+EIC+A ++ MCPL D + QRL+++C +AK+T+LFDN GTV FAIFMA
Sbjct: 421 LFTMNNSQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMA 480
Query: 276 LWATVFLEIWKRQRARVVLHWDLYVWDEEQEEM---------ALQLINCPDYKLRPYQHS 326
+WATVFLE WKR+R+ + WDL W+EE+E + ++++N K P+Q S
Sbjct: 481 IWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQPS 540
Query: 327 YLRSTVILVLT---LLMICLMIGMAHVLVVYRVLASALFSSSAVPFLEEQVTTAVVVTGA 383
+ T +LV MI L+I +VVYR++ F+S F+++ A
Sbjct: 541 SDKVTRLLVSVSGIFFMISLVITAVFGVVVYRLVVMEQFASFKWNFIKQYWQFATSAAAV 600
Query: 384 LVHYVTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFIL 443
++++ I+++ +A L + E PRT SE E+ F ++ F QF SS+ YIAF L
Sbjct: 601 CINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFL 660
Query: 444 GRINGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVP-----W 498
GR GHPGK +L W+LEECH SGC++DL +QM +IM LKQ +N +E P W
Sbjct: 661 GRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWW 720
Query: 499 VTHKCRSLRASESGHLPRDPELRDWRRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAF 558
HK + R +P+ W ++ L P+N L DE++EM++Q+GFTTIFVAAF
Sbjct: 721 SRHKIK--RGIHDASIPQ------WENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAF 772
Query: 559 PLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIA 618
PLAPLLAL +N++EIRLDA K V RR +P +A DIG WL +LE IG+LAVI N VIA
Sbjct: 773 PLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIA 832
Query: 619 FTSEFIPRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQDPDGIEGSENVTLC 678
TS++IPR VY+Y+Y PC + +CLKGYVN+SLS F + G C
Sbjct: 833 ITSDYIPRFVYEYKYGPCANHVEPSENCLKGYVNNSLSFFDLSEL-------GMGKSGYC 885
Query: 679 RYRDYRNPP----DYNFSEQFWFLLAIRLAFVILFEHVALCIKLIAAWFVPDIPQSVKNK 734
RYRDYR PP Y F+ Q+W +LA RLAF+I+FEH+ IK A+ +PD+P+ + ++
Sbjct: 886 RYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPKGLHDR 945
Query: 735 VLEVKY 740
+ KY
Sbjct: 946 IRREKY 951
>gi|218081589 anoctamin 5 isoform b [Homo sapiens]
Length = 912
Score = 437 bits (1123), Expect = e-122
Identities = 238/649 (36%), Positives = 365/649 (56%), Gaps = 55/649 (8%)
Query: 139 EDLMKDGVFEARFPLHKGEG--------------RLKKTWARWRHMFREQPVDEIRNYFG 184
E L+ + + +PLH G+ L + WAR+ + ++EQP+D I+NY+G
Sbjct: 237 ERLLNSNTYSSAYPLHDGQYWKPSEPPNPTNERYTLHQNWARFSYFYKEQPLDLIKNYYG 296
Query: 185 EKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEICEAH---DILMCPLGD 241
EK+ +YFV+LG+YT ML AA+ GL F+ G E + S EIC+ ++MCPL D
Sbjct: 297 EKIGIYFVFLGFYTEMLFFAAVVGLACFIYGLLSMEHNTSSTEICDPEIGGQMIMCPLCD 356
Query: 242 HSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHWDLYVW 301
Y RL+ TC +K +HLFDN+ TV FAIFM +W T+FLE WK+++AR+ WDL +
Sbjct: 357 QVCDYWRLNSTCLASKFSHLFDNESTVFFAIFMGIWVTLFLEFWKQRQARLEYEWDLVDF 416
Query: 302 DEEQEEMALQ----------LINCPDYKLRPYQHSYLR--------STVILVLTLLMICL 343
+EEQ+++ L+ +N ++ PY Y R +TV L ++L++ +
Sbjct: 417 EEEQQQLQLRPEFEAMCKHRKLNAVTKEMEPYMPLYTRIPWYFLSGATVTLWMSLVVTSM 476
Query: 344 MIGMAHVLVVYRVLASALFSSSAVP----FLEEQVTTAVVVTGALVHYVTIIIMTKINRC 399
+ + + L V+ AS + S +++ FL Q+TT++ TG+ ++++ I+I+
Sbjct: 477 VAVIVYRLSVFATFASFMESDASLKQVKSFLTPQITTSL--TGSCLNFIVILILNFFYEK 534
Query: 400 VALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRINGHPGKSTRLAGL 459
++ + E+PRT+ E ES T++ F QF +SS Y+AF G+ G+PGK T L
Sbjct: 535 ISAWITKMEIPRTYQEYESSLTLKMFLFQFVNFYSSCFYVAFFKGKFVGYPGKYTYLFNE 594
Query: 460 WKLEECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKCRSLRASESGHLPRDPE 519
W+ EEC GC+++L Q+ IIM KQ N E + P + R +A + +
Sbjct: 595 WRSEECDPGGCLIELTTQLTIIMTGKQIFGNIKEAIYPLALNWWRRRKARTNS----EKL 650
Query: 520 LRDWRRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIK 579
W +++ L LF E++E + Q+GF T+FVA+FPLAPLLAL +N+VEIR+DA K
Sbjct: 651 YSRWEQDHDLESFGPLGLFYEYLETVTQFGFVTLFVASFPLAPLLALINNIVEIRVDAWK 710
Query: 580 MVWLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKE 639
+ RR V KA IG W +L + VL+V N ++AFTS+ IPR+VY Y YS
Sbjct: 711 LTTQYRRTVASKAHSIGVWQDILYGMAVLSVATNAFIVAFTSDIIPRLVYYYAYS----- 765
Query: 640 GNSTVDCLKGYVNHSLSVFHTKDFQDPDGIEGSENVTLCRYRDYRNPPD----YNFSEQF 695
+ + GYVN+SLSVF DF + + CRYRDYR PPD Y + QF
Sbjct: 766 -TNATQPMTGYVNNSLSVFLIADFPNHTAPSEKRDFITCRYRDYRYPPDDENKYFHNMQF 824
Query: 696 WFLLAIRLAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKYQRLR 744
W +LA ++ F+I+ EHV +K + AW +PD+P+ V ++ K ++
Sbjct: 825 WHVLAAKMTFIIVMEHVVFLVKFLLAWMIPDVPKDVVERIKREKLMTIK 873
>gi|47106048 anoctamin 5 isoform a [Homo sapiens]
Length = 913
Score = 437 bits (1123), Expect = e-122
Identities = 238/649 (36%), Positives = 365/649 (56%), Gaps = 55/649 (8%)
Query: 139 EDLMKDGVFEARFPLHKGEG--------------RLKKTWARWRHMFREQPVDEIRNYFG 184
E L+ + + +PLH G+ L + WAR+ + ++EQP+D I+NY+G
Sbjct: 238 ERLLNSNTYSSAYPLHDGQYWKPSEPPNPTNERYTLHQNWARFSYFYKEQPLDLIKNYYG 297
Query: 185 EKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEICEAH---DILMCPLGD 241
EK+ +YFV+LG+YT ML AA+ GL F+ G E + S EIC+ ++MCPL D
Sbjct: 298 EKIGIYFVFLGFYTEMLFFAAVVGLACFIYGLLSMEHNTSSTEICDPEIGGQMIMCPLCD 357
Query: 242 HSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHWDLYVW 301
Y RL+ TC +K +HLFDN+ TV FAIFM +W T+FLE WK+++AR+ WDL +
Sbjct: 358 QVCDYWRLNSTCLASKFSHLFDNESTVFFAIFMGIWVTLFLEFWKQRQARLEYEWDLVDF 417
Query: 302 DEEQEEMALQ----------LINCPDYKLRPYQHSYLR--------STVILVLTLLMICL 343
+EEQ+++ L+ +N ++ PY Y R +TV L ++L++ +
Sbjct: 418 EEEQQQLQLRPEFEAMCKHRKLNAVTKEMEPYMPLYTRIPWYFLSGATVTLWMSLVVTSM 477
Query: 344 MIGMAHVLVVYRVLASALFSSSAVP----FLEEQVTTAVVVTGALVHYVTIIIMTKINRC 399
+ + + L V+ AS + S +++ FL Q+TT++ TG+ ++++ I+I+
Sbjct: 478 VAVIVYRLSVFATFASFMESDASLKQVKSFLTPQITTSL--TGSCLNFIVILILNFFYEK 535
Query: 400 VALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRINGHPGKSTRLAGL 459
++ + E+PRT+ E ES T++ F QF +SS Y+AF G+ G+PGK T L
Sbjct: 536 ISAWITKMEIPRTYQEYESSLTLKMFLFQFVNFYSSCFYVAFFKGKFVGYPGKYTYLFNE 595
Query: 460 WKLEECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKCRSLRASESGHLPRDPE 519
W+ EEC GC+++L Q+ IIM KQ N E + P + R +A + +
Sbjct: 596 WRSEECDPGGCLIELTTQLTIIMTGKQIFGNIKEAIYPLALNWWRRRKARTNS----EKL 651
Query: 520 LRDWRRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIK 579
W +++ L LF E++E + Q+GF T+FVA+FPLAPLLAL +N+VEIR+DA K
Sbjct: 652 YSRWEQDHDLESFGPLGLFYEYLETVTQFGFVTLFVASFPLAPLLALINNIVEIRVDAWK 711
Query: 580 MVWLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKE 639
+ RR V KA IG W +L + VL+V N ++AFTS+ IPR+VY Y YS
Sbjct: 712 LTTQYRRTVASKAHSIGVWQDILYGMAVLSVATNAFIVAFTSDIIPRLVYYYAYS----- 766
Query: 640 GNSTVDCLKGYVNHSLSVFHTKDFQDPDGIEGSENVTLCRYRDYRNPPD----YNFSEQF 695
+ + GYVN+SLSVF DF + + CRYRDYR PPD Y + QF
Sbjct: 767 -TNATQPMTGYVNNSLSVFLIADFPNHTAPSEKRDFITCRYRDYRYPPDDENKYFHNMQF 825
Query: 696 WFLLAIRLAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKYQRLR 744
W +LA ++ F+I+ EHV +K + AW +PD+P+ V ++ K ++
Sbjct: 826 WHVLAAKMTFIIVMEHVVFLVKFLLAWMIPDVPKDVVERIKREKLMTIK 874
>gi|218156303 anoctamin 6 isoform b [Homo sapiens]
Length = 892
Score = 424 bits (1091), Expect = e-118
Identities = 242/672 (36%), Positives = 383/672 (56%), Gaps = 56/672 (8%)
Query: 123 VNFVVMNNKTSAGETFEDLMKDGVFEARFPLHKGEGR--------------LKKTWARWR 168
V + V+NN + G L+ G+++A FPLH + R L + WA R
Sbjct: 201 VKYQVINNVSKFG--INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPR 258
Query: 169 HMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEI 228
++++QP+D IR Y+GEK+ +YF WLG+YT ML+ AA+ G+ FL G+ + SKE+
Sbjct: 259 SIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEV 318
Query: 229 CEAH---DILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIW 285
C I+MCP D + +L+ TC +K +FD+ GT+VFA+FM +W T+FLE W
Sbjct: 319 CHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFW 378
Query: 286 KRQRARVVLHWDLYVWDEEQEEMALQLINCPDYKLRPYQHSY-----------LRSTVIL 334
KR++A + WD +E++ C + +R T+
Sbjct: 379 KRRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCA 438
Query: 335 VLTLLMICLMIGMAHVLVVYRVLASALFSS------SAVPFLEEQVT--TAVVVTGALVH 386
I L+I ++VYR+ +FS+ + +++ +T TA +T +++
Sbjct: 439 SAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIIS 498
Query: 387 YVTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRI 446
++ I+I+ I VA+ + +FE+PRT ++ E+ T++ F QF ++SS YIAF G+
Sbjct: 499 FIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKF 558
Query: 447 NGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKC-RS 505
G+PG G ++ EEC GC+++L Q+ IIMG K +N E L+PW+ + R
Sbjct: 559 VGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRF 618
Query: 506 LRASESGHL-PRDPELRDWRRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLL 564
R S S + PR W ++Y L P+ LF E++EM+IQ+GF T+FVA+FPLAPLL
Sbjct: 619 HRVSGSEKITPR------WEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLL 672
Query: 565 ALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFI 624
AL +N++EIR+DA K+ RRLVP KA+DIG W +++ I +LAV+ N M+IAFTS+ I
Sbjct: 673 ALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMI 732
Query: 625 PRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQDPD-GIEGSE--NVTLCRYR 681
PR+VY + +S G+ T ++GY+N++LS+F DF++ G S+ N T CRYR
Sbjct: 733 PRLVYYWSFS-VPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYR 791
Query: 682 DYRNPP----DYNFSEQFWFLLAIRLAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLE 737
D+R PP +Y + +W ++A +LAF+I+ EHV +K ++ +PD+ + K+K+
Sbjct: 792 DFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQR 851
Query: 738 VKYQRLREKMWH 749
KY L +K+ H
Sbjct: 852 EKY--LTQKLLH 861
>gi|218156299 anoctamin 6 isoform a [Homo sapiens]
Length = 910
Score = 424 bits (1091), Expect = e-118
Identities = 242/672 (36%), Positives = 383/672 (56%), Gaps = 56/672 (8%)
Query: 123 VNFVVMNNKTSAGETFEDLMKDGVFEARFPLHKGEGR--------------LKKTWARWR 168
V + V+NN + G L+ G+++A FPLH + R L + WA R
Sbjct: 219 VKYQVINNVSKFG--INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPR 276
Query: 169 HMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEI 228
++++QP+D IR Y+GEK+ +YF WLG+YT ML+ AA+ G+ FL G+ + SKE+
Sbjct: 277 SIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEV 336
Query: 229 CEAH---DILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIW 285
C I+MCP D + +L+ TC +K +FD+ GT+VFA+FM +W T+FLE W
Sbjct: 337 CHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFW 396
Query: 286 KRQRARVVLHWDLYVWDEEQEEMALQLINCPDYKLRPYQHSY-----------LRSTVIL 334
KR++A + WD +E++ C + +R T+
Sbjct: 397 KRRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCA 456
Query: 335 VLTLLMICLMIGMAHVLVVYRVLASALFSS------SAVPFLEEQVT--TAVVVTGALVH 386
I L+I ++VYR+ +FS+ + +++ +T TA +T +++
Sbjct: 457 SAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIIS 516
Query: 387 YVTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRI 446
++ I+I+ I VA+ + +FE+PRT ++ E+ T++ F QF ++SS YIAF G+
Sbjct: 517 FIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKF 576
Query: 447 NGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKC-RS 505
G+PG G ++ EEC GC+++L Q+ IIMG K +N E L+PW+ + R
Sbjct: 577 VGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRF 636
Query: 506 LRASESGHL-PRDPELRDWRRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLL 564
R S S + PR W ++Y L P+ LF E++EM+IQ+GF T+FVA+FPLAPLL
Sbjct: 637 HRVSGSEKITPR------WEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLL 690
Query: 565 ALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFI 624
AL +N++EIR+DA K+ RRLVP KA+DIG W +++ I +LAV+ N M+IAFTS+ I
Sbjct: 691 ALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMI 750
Query: 625 PRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQDPD-GIEGSE--NVTLCRYR 681
PR+VY + +S G+ T ++GY+N++LS+F DF++ G S+ N T CRYR
Sbjct: 751 PRLVYYWSFS-VPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYR 809
Query: 682 DYRNPP----DYNFSEQFWFLLAIRLAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLE 737
D+R PP +Y + +W ++A +LAF+I+ EHV +K ++ +PD+ + K+K+
Sbjct: 810 DFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQR 869
Query: 738 VKYQRLREKMWH 749
KY L +K+ H
Sbjct: 870 EKY--LTQKLLH 879
>gi|194306539 anoctamin 1, calcium activated chloride channel [Homo
sapiens]
Length = 986
Score = 416 bits (1070), Expect = e-116
Identities = 255/724 (35%), Positives = 382/724 (52%), Gaps = 101/724 (13%)
Query: 131 KTSAGETFEDLMKDGVFEARFPLHKGEGR-----------LKKTWARWRHMFREQPVDEI 179
K S G T L+ +GV+ A +PLH G+ L + WAR+ ++ QP+D +
Sbjct: 263 KYSMGIT--SLLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLV 320
Query: 180 RNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEICEA-HDILMCP 238
R YFGEK+ LYF WLG YT ML+PA++ G++VFL G + + + S E+C+ H+I MCP
Sbjct: 321 RKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCP 380
Query: 239 LGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHWDL 298
L D + Y ++S C A+ +HLFDN TV F++FMALWA F+E WKR++ R+ WDL
Sbjct: 381 LCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDL 440
Query: 299 YVWDEEQEEM--------------------------------------------ALQLIN 314
++EE+E + A+ +
Sbjct: 441 TGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQRVKTAMAGVK 500
Query: 315 CPDYKLRPYQHSYLRSTVILVLTLLMICLMIGMAHVLVVYRVLASALFSSSAVPFLEEQV 374
D ++ + LV + MI + + +++YR+ +A + ++ P + +
Sbjct: 501 LTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNI 560
Query: 375 TTAVVVTGALVHYVTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFS 434
V T +++ V II++ ++ C+A L E+P+T E R + F L+F ++
Sbjct: 561 RVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLLKFVNSYT 620
Query: 435 SLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTL-SNCVE 493
+ Y+AF GR G PG + +++EEC GC+M+L +Q++IIM KQ + +N E
Sbjct: 621 PIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFE 680
Query: 494 YLVPWVTHKCRSLRASESGHLPRDPELRDWRR---NYLLNPVNTFSLFDEFMEMMIQYGF 550
+P + R L+ + + ++ +R +Y L P L E+MEM+IQ+GF
Sbjct: 681 IGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLEPFA--GLTPEYMEMIIQFGF 738
Query: 551 TTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGVLAV 610
T+FVA+FPLAPL AL +N++EIRLDA K V RR V +AKDIG W +L IG LAV
Sbjct: 739 VTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGIWYNILRGIGKLAV 798
Query: 611 IANGMVIAFTSEFIPRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQD----P 666
I N VI+FTS+FIPR+VY Y YS K G + G+VNH+LS F+ DFQ+
Sbjct: 799 IINAFVISFTSDFIPRLVYLYMYS---KNGT-----MHGFVNHTLSSFNVSDFQNGTAPN 850
Query: 667 DGIEGSENVTLCRYRDYRNPP----DYNFSEQFWFLLAIRLAFVILFEHVALCIKLIAAW 722
D ++ V +CRY+DYR PP Y+ S+ FW +LA RLAFVI+F+++ + + W
Sbjct: 851 DPLDLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDW 910
Query: 723 FVPDIPQSV-----KNKVLEV---------KYQRLREKMWHGRQRLGGVGAGSRPPMPAH 768
+PDIP+ + K KVL V K Q L M RQ+ PP H
Sbjct: 911 VIPDIPKDISQQIHKEKVLMVELFMREEQDKQQLLETWMEKERQK-------DEPPCNHH 963
Query: 769 PTPA 772
T A
Sbjct: 964 NTKA 967
>gi|209862785 anoctamin 2 [Homo sapiens]
Length = 998
Score = 411 bits (1057), Expect = e-114
Identities = 252/683 (36%), Positives = 372/683 (54%), Gaps = 79/683 (11%)
Query: 119 RIRIVNFVVMNNKTSAGET---FEDLMKDGVFEARFPLHKGE-----------GRLKKTW 164
R RIV+ ++ S L+ + ++EA +PLH GE L + W
Sbjct: 273 RSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEW 332
Query: 165 ARWRHMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQI 224
AR+ ++ QP+D IR YFGEK+ LYF WLG YT L+P+++ G++VFL G + E
Sbjct: 333 ARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIP 392
Query: 225 SKEICEAHDIL-MCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLE 283
S+E+C+ + MCPL D S Y LS C A+ +HLFDN TV F+IFMALWAT+FLE
Sbjct: 393 SREMCDQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLE 452
Query: 284 IWKRQRARVVLHWDLYVWDEEQEEMALQLINCPDYKLRPYQHSYLRSTVILV-------- 335
WKR + R+ WDL +EE+E Q + P+Y+ + + S V
Sbjct: 453 NWKRLQMRLGYFWDLTGIEEEEERA--QEHSRPEYETKVREKMLKESNQSAVQKLETNTT 510
Query: 336 ----------LT---------------LLMICLMIGMAHVLVVYRVLASALFSSSAVPFL 370
LT L MI L + ++VYR+ +A S +
Sbjct: 511 ECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRITTAAALSLNKATRS 570
Query: 371 EEQVTTAVVVTGALVHYVTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFF 430
+VT V T +++ V I+I+ +I VA L E+P+T E R ++ F L+F
Sbjct: 571 NVRVT--VTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFV 628
Query: 431 THFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLSN 490
+S + Y+AF GR G PG + +++EEC GC+M+L +Q++IIM KQ + N
Sbjct: 629 NAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQN 688
Query: 491 CV-EYLVPWVTHKCRSLR------ASESGHLPRDPELRDWRRNYLLNPVNTFSLFDEFME 543
+ E VP + R L+ ++S H + PE W +Y L P L E+ME
Sbjct: 689 NIFEIGVPKLKKLFRKLKDETEAGETDSAH-SKHPE--QWDLDYSLEPYT--GLTPEYME 743
Query: 544 MMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLE 603
M+IQ+GF T+FVA+FPLAP+ AL +N++E+RLDA K V RR + KDIG W +L
Sbjct: 744 MIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILS 803
Query: 604 TIGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHT--- 660
IG +VI+N VIA TS+FIPR+VY+Y YS N T L G+VNH+LS F+
Sbjct: 804 GIGKFSVISNAFVIAITSDFIPRLVYQYSYS-----HNGT---LHGFVNHTLSFFNVSQL 855
Query: 661 KDFQDPDGIEGSENVTLCRYRDYRNPP----DYNFSEQFWFLLAIRLAFVILFEHVALCI 716
K+ P+ + + V CR++DYR PP Y FS+Q+WF+L+ RLAFVI+F+++ + +
Sbjct: 856 KEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVMFL 915
Query: 717 KLIAAWFVPDIPQSVKNKVLEVK 739
++ W +PDIP + +++ + K
Sbjct: 916 SVLVDWMIPDIPTDISDQIKKEK 938
>gi|218156307 anoctamin 6 isoform c [Homo sapiens]
Length = 929
Score = 405 bits (1042), Expect = e-113
Identities = 233/641 (36%), Positives = 367/641 (57%), Gaps = 54/641 (8%)
Query: 123 VNFVVMNNKTSAGETFEDLMKDGVFEARFPLHKGEGR--------------LKKTWARWR 168
V + V+NN + G L+ G+++A FPLH + R L + WA R
Sbjct: 219 VKYQVINNVSKFG--INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPR 276
Query: 169 HMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEI 228
++++QP+D IR Y+GEK+ +YF WLG+YT ML+ AA+ G+ FL G+ + SKE+
Sbjct: 277 SIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEV 336
Query: 229 CEAH---DILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIW 285
C I+MCP D + +L+ TC +K +FD+ GT+VFA+FM +W T+FLE W
Sbjct: 337 CHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFW 396
Query: 286 KRQRARVVLHWDLYVWDEEQEEMALQLINCPDYKLRPYQHSY-----------LRSTVIL 334
KR++A + WD +E++ C + +R T+
Sbjct: 397 KRRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCA 456
Query: 335 VLTLLMICLMIGMAHVLVVYRVLASALFSS------SAVPFLEEQVT--TAVVVTGALVH 386
I L+I ++VYR+ +FS+ + +++ +T TA +T +++
Sbjct: 457 SAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIIS 516
Query: 387 YVTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRI 446
++ I+I+ I VA+ + +FE+PRT ++ E+ T++ F QF ++SS YIAF G+
Sbjct: 517 FIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKF 576
Query: 447 NGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKC-RS 505
G+PG G ++ EEC GC+++L Q+ IIMG K +N E L+PW+ + R
Sbjct: 577 VGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRF 636
Query: 506 LRASESGHL-PRDPELRDWRRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLL 564
R S S + PR W ++Y L P+ LF E++EM+IQ+GF T+FVA+FPLAPLL
Sbjct: 637 HRVSGSEKITPR------WEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLL 690
Query: 565 ALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFI 624
AL +N++EIR+DA K+ RRLVP KA+DIG W +++ I +LAV+ N M+IAFTS+ I
Sbjct: 691 ALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMI 750
Query: 625 PRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQDPD-GIEGSE--NVTLCRYR 681
PR+VY + +S G+ T ++GY+N++LS+F DF++ G S+ N T CRYR
Sbjct: 751 PRLVYYWSFS-VPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYR 809
Query: 682 DYRNPP----DYNFSEQFWFLLAIRLAFVILFEHVALCIKL 718
D+R PP +Y + +W ++A +LAF+I+ E++AL +L
Sbjct: 810 DFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEYLALLPRL 850
>gi|218156305 anoctamin 6 isoform c [Homo sapiens]
Length = 929
Score = 405 bits (1042), Expect = e-113
Identities = 233/641 (36%), Positives = 367/641 (57%), Gaps = 54/641 (8%)
Query: 123 VNFVVMNNKTSAGETFEDLMKDGVFEARFPLHKGEGR--------------LKKTWARWR 168
V + V+NN + G L+ G+++A FPLH + R L + WA R
Sbjct: 219 VKYQVINNVSKFG--INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPR 276
Query: 169 HMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEI 228
++++QP+D IR Y+GEK+ +YF WLG+YT ML+ AA+ G+ FL G+ + SKE+
Sbjct: 277 SIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEV 336
Query: 229 CEAH---DILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIW 285
C I+MCP D + +L+ TC +K +FD+ GT+VFA+FM +W T+FLE W
Sbjct: 337 CHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFW 396
Query: 286 KRQRARVVLHWDLYVWDEEQEEMALQLINCPDYKLRPYQHSY-----------LRSTVIL 334
KR++A + WD +E++ C + +R T+
Sbjct: 397 KRRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCA 456
Query: 335 VLTLLMICLMIGMAHVLVVYRVLASALFSS------SAVPFLEEQVT--TAVVVTGALVH 386
I L+I ++VYR+ +FS+ + +++ +T TA +T +++
Sbjct: 457 SAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIIS 516
Query: 387 YVTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRI 446
++ I+I+ I VA+ + +FE+PRT ++ E+ T++ F QF ++SS YIAF G+
Sbjct: 517 FIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKF 576
Query: 447 NGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKC-RS 505
G+PG G ++ EEC GC+++L Q+ IIMG K +N E L+PW+ + R
Sbjct: 577 VGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRF 636
Query: 506 LRASESGHL-PRDPELRDWRRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLL 564
R S S + PR W ++Y L P+ LF E++EM+IQ+GF T+FVA+FPLAPLL
Sbjct: 637 HRVSGSEKITPR------WEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLL 690
Query: 565 ALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFI 624
AL +N++EIR+DA K+ RRLVP KA+DIG W +++ I +LAV+ N M+IAFTS+ I
Sbjct: 691 ALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMI 750
Query: 625 PRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQDPD-GIEGSE--NVTLCRYR 681
PR+VY + +S G+ T ++GY+N++LS+F DF++ G S+ N T CRYR
Sbjct: 751 PRLVYYWSFS-VPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYR 809
Query: 682 DYRNPP----DYNFSEQFWFLLAIRLAFVILFEHVALCIKL 718
D+R PP +Y + +W ++A +LAF+I+ E++AL +L
Sbjct: 810 DFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEYLALLPRL 850
>gi|145207958 transmembrane protein 16G isoform NGEP long [Homo
sapiens]
Length = 933
Score = 379 bits (973), Expect = e-105
Identities = 245/673 (36%), Positives = 364/673 (54%), Gaps = 67/673 (9%)
Query: 141 LMKDGVFEARFPLHKGEGR----------------LKKTWARWRHMFREQPVDEIRNYFG 184
L+ +GV A FPLH G + L + WARW + QP+D +R YFG
Sbjct: 281 LLAEGVLSAAFPLHDGPFKTPPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVRRYFG 340
Query: 185 EKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEICEAHDIL-MCPLGDHS 243
EKVALYF WLG+YT L+PAA+ G LVFL G L + ++E+C + D MCPL
Sbjct: 341 EKVALYFAWLGFYTGWLLPAAVVGTLVFLVGCFLVFSDIPTQELCGSKDSFEMCPLCLDC 400
Query: 244 RRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHWDLYVWDE 303
+ LS C A+ LFD+ GTV F++FMALWA + LE WKR+ A + WD +++
Sbjct: 401 P-FWLLSSACALAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKSATLAYRWDCSDYED 459
Query: 304 EQEEMALQL-----------INCPDYKLRPYQHSYLRSTVILVLTLLMICLMIGMAHVLV 352
+E Q I D P + R V+ ++M+ +++ ++
Sbjct: 460 TEERPRPQFAASAPMTAPNPITGEDEPYFPERSRARRMLAGSVVIVVMVAVVVMCLVSII 519
Query: 353 VYRVLASALFSSSAVPFLEEQVTTAVVVTGALVHYVTIIIMTKINRCVALKLCDFEMPRT 412
+YR + + + S S L + +TG++V+ V I+I++KI +A L +EM RT
Sbjct: 520 LYRAIMAIVVSRSGNTLLAAWASRIASLTGSVVNLVFILILSKIYVSLAHVLTRWEMHRT 579
Query: 413 FSERESRFTIRFFTLQFFTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMM 472
++ E FT++ F QF +SS +YIAF GR G+PG L G+ + EEC A GC++
Sbjct: 580 QTKFEDAFTLKVFIFQFVNFYSSPVYIAFFKGRFVGYPGNYHTLFGV-RNEECAAGGCLI 638
Query: 473 DLFVQMAIIMGLKQTLSNCVEYLVP-----WVTHKCRSLR--ASESGHLPRDPELRDWRR 525
+L ++ +IM KQ ++N E L+P W + RS + A S + P W
Sbjct: 639 ELAQELLVIMVGKQVINNMQEVLIPKLKGWWQKFRLRSKKRKAGASAGASQGP----WED 694
Query: 526 NYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQR 585
+Y L P LFDE++EM++Q+GF TIFVAA PLAPL AL +N VEIRLDA K V R
Sbjct: 695 DYELVPCE--GLFDEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYR 752
Query: 586 RLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKEGNSTVD 645
R V +A+DIG W +L + LAVI+N ++AF+S+F+PR Y++ +
Sbjct: 753 RPVAERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPRAYYRW----------TRAH 802
Query: 646 CLKGYVNHSLSVFHTKDFQDPDGIEGSENVTLCRYRDYRNPPDYNFSEQFWFLLAIRLAF 705
L+G++N +L+ + P + N T CRYR +R+ D ++S+ +W LLAIRLAF
Sbjct: 803 DLRGFLNFTLA-------RAPSSFAAAHNRT-CRYRAFRD-DDGHYSQTYWNLLAIRLAF 853
Query: 706 VILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKYQRLREKMWHGRQRLGGVGAGSRPP- 764
VI+FEHV + + VPDIP+SV+ KV + +Y ++ + G G P
Sbjct: 854 VIVFEHVVFSVGRLLDLLVPDIPESVEIKV-KREYYLAKQALAENEVLFGTNGTKDEQPE 912
Query: 765 ---MPAHPTPASI 774
+ +H TP ++
Sbjct: 913 GSELSSHWTPFTV 925
>gi|94536803 transmembrane protein 16K [Homo sapiens]
Length = 660
Score = 157 bits (398), Expect = 3e-38
Identities = 125/495 (25%), Positives = 217/495 (43%), Gaps = 89/495 (17%)
Query: 141 LMKDGVFEARFPLHKGEG--RLKKTWARWRHMFREQPVDEIRNYFGEKVALYFVWLGWYT 198
L+ G+ FPLH E +L+ TW R + QP+D IR YFGE +ALYF +L ++T
Sbjct: 161 LLTSGIVIQVFPLHDSEALKKLEDTWYT-RFALKYQPIDSIRGYFGETIALYFGFLEYFT 219
Query: 199 YMLVPAALTGLLVFLSGFSLFEASQISKEICEAHDILMCPLGDHSRRYQRLSETCTFAKL 258
+ L+P A+ GL +L +
Sbjct: 220 FALIPMAVIGLPYYLFVWE----------------------------------------- 238
Query: 259 THLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHWDLYVWDEEQEEM-----ALQLI 313
D D V+FA F +W+TV LE+WKR A + W + + EE + I
Sbjct: 239 ----DYDKYVIFASFNLIWSTVILELWKRGCANMTYRWGTLLMKRKFEEPRPGFHGVLGI 294
Query: 314 NCPDYKLRPYQHSYLRSTVILVLTLLMICLMIGMA-HVLVVY---RVLASALFSSSAVPF 369
N K P SY R I +++L +CL + + +V+++Y V A L +S
Sbjct: 295 NSITGKEEPLYPSYKRQLRIYLVSLPFVCLCLYFSLYVMMIYFDMEVWALGLHENSG--- 351
Query: 370 LEEQVTTAVVVTGALVHYVTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQF 429
+ T+ ++ ++++ + I IM ++ R A L +E R S ++ ++ F
Sbjct: 352 --SEWTSVLLYVPSIIYAIVIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNF 409
Query: 430 FTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLS 489
F+SL YIAF+L K +L L +A ++ Q L+
Sbjct: 410 LNCFASLFYIAFVL--------KDMKL-----------------LRQSLATLLITSQILN 444
Query: 490 NCVEYLVPWVTHKCRSLRASESGH-LPRDPELRDWRRNYLLNPVNTF-SLFDEFMEMMIQ 547
+E +P+ + +R L D + + + L + T+ FD+++E+ +Q
Sbjct: 445 QIMESFLPYWLQRKHGVRVKRKVQALKADIDATLYEQVILEKEMGTYLGTFDDYLELFLQ 504
Query: 548 YGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGV 607
+G+ ++F +PLA A+ +N E+ DA+KM + +R + +IG W ET+ V
Sbjct: 505 FGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQLAFETMSV 564
Query: 608 LAVIANGMVIAFTSE 622
++V+ N +I + +
Sbjct: 565 ISVVTNCALIGMSPQ 579
Score = 32.3 bits (72), Expect = 1.7
Identities = 12/41 (29%), Positives = 25/41 (60%)
Query: 703 LAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKYQRL 743
+ V+ EH L +K I A+ +PD P+ ++ K+ ++++ L
Sbjct: 592 ILIVVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESL 632
>gi|55741655 anoctamin 8 [Homo sapiens]
Length = 1232
Score = 90.1 bits (222), Expect = 7e-18
Identities = 89/354 (25%), Positives = 145/354 (40%), Gaps = 79/354 (22%)
Query: 115 TTSLRIRIVNFVVMNNKTSAGETFE------------DLMKDGVFEARFPLHKGE--GRL 160
T+ R I+ F + N + GE +L G+ + FP+H+ RL
Sbjct: 161 TSQERQSIIRFWLQNLRAKQGEALHNVRFLEDQPIIPELAARGIIQQVFPVHEQRILNRL 220
Query: 161 KKTWARWRHMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFE 220
K+W + + QP+D+I +YFG K+A+YF WLG+YT +V A+ G ++ ++ E
Sbjct: 221 MKSWVQ--AVCENQPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVL----YTFTE 274
Query: 221 ASQISKEICEAHDILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATV 280
A Q S+++ VVFA+F +W+T+
Sbjct: 275 ADQTSRDV-------------------------------------SCVVFALFNVIWSTL 297
Query: 281 FLEIWKRQRARVVLHW-DLYVWDEEQEEMALQ---------LINCPDYKLRPYQHSYLRS 330
FLE WKR+ A + W L E EE Q + ++ P++ +
Sbjct: 298 FLEEWKRRGAELAYKWGTLDSPGEAVEEPRPQFRGVRRISPITRAEEFYYPPWKRLLFQL 357
Query: 331 TVILVLTL-LMICLMIGMAHVLVVYRVLASALFSSSAVPFLEEQVTTAVVVTGALVHYVT 389
V L L L ++C+ + M + ++ S FL +V A++V+ + Y
Sbjct: 358 LVSLPLCLACLVCVFLLMLGCFQLQELVLSVKGLPRLARFL-PKVMLALLVSVSAEGY-- 414
Query: 390 IIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFIL 443
+ +A+ L D E R S E I+ QF + SL YI F L
Sbjct: 415 --------KKLAIWLNDMENYRLESAYEKHLIIKVVLFQFVNSYLSLFYIGFYL 460
Score = 74.7 bits (182), Expect = 3e-13
Identities = 34/80 (42%), Positives = 54/80 (67%)
Query: 538 FDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGT 597
F ++ EM +Q+G+ +F +AFPLA L AL +NL+EIR DA K+ +R ++ + IG
Sbjct: 745 FQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKLCTGLQRPFGQRVESIGQ 804
Query: 598 WLQVLETIGVLAVIANGMVI 617
W +V+E +GVLA++ N +I
Sbjct: 805 WQKVMEAMGVLAIVVNCYLI 824
Score = 36.2 bits (82), Expect = 0.12
Identities = 18/57 (31%), Positives = 29/57 (50%)
Query: 696 WFLLAIRLAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKYQRLREKMWHGRQ 752
W + V++ EH AL +K + +PDIP V ++ +++YQR H RQ
Sbjct: 836 WLSPEAAIVSVVVLEHFALLLKYLIHVAIPDIPGWVAEEMAKLEYQRREAFKRHERQ 892
>gi|239747244 PREDICTED: hypothetical protein [Homo sapiens]
Length = 719
Score = 63.2 bits (152), Expect = 9e-10
Identities = 134/554 (24%), Positives = 195/554 (35%), Gaps = 127/554 (22%)
Query: 245 RYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHWDL------ 298
+YQ L + KL+ LFD+ GTV F+IFM+ W + A + HWD
Sbjct: 244 KYQPLDQPLD--KLSCLFDHPGTVFFSIFMSFWGHGLPGALEAGSATLAHHWDCSDFQDQ 301
Query: 299 --------YVWD----EEQEEM---ALQLINCPDYKLRPYQHSYLRSTVILVLTLLMICL 343
+ WD ++QE M AL +C D++ + + + L +T +
Sbjct: 302 EAMPSSAPHHWDCSDFQDQEVMPSSALHHWDCSDFQDQEECPHLQFAALALQMTQNPVT- 360
Query: 344 MIGMAHVLVVYRVLASALFSSSAVPFLEEQVTTAVVVTGALVHYVTIIIMTKINRCVALK 403
G+ S L +SSA V +V+ + H + I M V +
Sbjct: 361 --GLKEPYFQPHSCLSHLLTSSAAILTVLCVVMIFLVSVIIYHGIISIAMFHTGNSVLMT 418
Query: 404 LCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLE 463
+ ++ F QF F SL++ IL R
Sbjct: 419 QANVLWGNGGDASMKMPSLSFSVCQFL--FFSLLH--GILQR------------------ 456
Query: 464 ECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKCRSLRASESGHLPRDPELRDW 523
+C GC + + Q+ IIM KQ L++ E++ L P PEL
Sbjct: 457 QCGPGGCHIQVTQQLIIIMVGKQLLNHMEEFV---------GLGGGPGPDTPCLPEL--- 504
Query: 524 RRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVW- 582
Q+GF TIFV AF LAPL L +N VEI LDA K +
Sbjct: 505 -----------------------QFGFITIFVGAFLLAPLFTLLNNRVEIGLDAHKFLCK 541
Query: 583 LQRRLVPR---KAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKE 639
QR + R D W + E I +PR + R L
Sbjct: 542 YQRPMAGRGWTSGSDCSCW-RPCELI------------------LPRTNARSRLGYWLNG 582
Query: 640 GNSTVDCLKGYVNHSLSVFHTKDFQDPDGIEGSENVTLCRYRDYRNPPDYNFSEQFWFLL 699
+ +G N V + Q P RY+ R+ N + +W LL
Sbjct: 583 QGQILGRRRG-GNAGFGVEIREPLQTPQP----------RYKASRD-VGVNLALFYWKLL 630
Query: 700 A--IRLAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKYQRLREKMWHGRQRLGGV 757
A + L F+I FE+V VPD+P ++ + L + GRQ V
Sbjct: 631 AVHVHLGFIIAFENVVFFFLCPNDRLVPDVPA----LATKITARALPGQAGGGRQPGDAV 686
Query: 758 G---AGSRPPMPAH 768
AG P P H
Sbjct: 687 SVSKAGGPRPHPQH 700
>gi|239741065 PREDICTED: hypothetical protein [Homo sapiens]
Length = 494
Score = 61.6 bits (148), Expect = 3e-09
Identities = 136/554 (24%), Positives = 200/554 (36%), Gaps = 148/554 (26%)
Query: 245 RYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHWDL------ 298
+YQ L + KL+ LFD+ GTV F+IFM+ W + A + HWD
Sbjct: 40 KYQPLDQPLD--KLSCLFDHPGTVFFSIFMSFWGHGLPGALEAGSATLAHHWDCSDFQDQ 97
Query: 299 --------YVWD----EEQEEM---ALQLINCPDYKLRPYQHSYLRSTVILVLTLLMICL 343
+ WD ++QE M AL +C D++ + + L+ T V L
Sbjct: 98 EAMPSSAPHHWDCSDFQDQEVMPSSALHHWDCSDFQDQEFAALALQMTQNPVTGL----- 152
Query: 344 MIGMAHVLVVYRVLASALFSSSAVPFLEEQVTTAVVVTGALVHYVTIIIMTKINRCVALK 403
+ L+ L SS+A+ +T VV ++ V++II I
Sbjct: 153 ---KEPYFQPHSCLSHLLTSSAAI------LTVLCVV---MIFLVSVIIYHGI------- 193
Query: 404 LCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLE 463
F T S L+ A +L NG P +++ + + +
Sbjct: 194 --------------------ISIAMFHTGNSVLMTQANVLWG-NGGPKALSKVLCVCQ-Q 231
Query: 464 ECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKCRSLRASESGHLPRDPELRDW 523
+C GC + + Q+ IIM KQ L++ E++ L P PEL
Sbjct: 232 QCGPGGCHIQVTQQLIIIMVGKQLLNHMEEFV---------GLGGGPGPDTPCLPEL--- 279
Query: 524 RRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVW- 582
Q+GF TIFV AF LAPL L +N VEI LDA K +
Sbjct: 280 -----------------------QFGFITIFVGAFLLAPLFTLLNNRVEIGLDAHKFLCK 316
Query: 583 LQRRLVPR---KAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKE 639
QR + R D W + E I +PR + R L
Sbjct: 317 YQRPMAGRGWTSGSDCSCW-RPCELI------------------LPRTNARSRLGYWLNG 357
Query: 640 GNSTVDCLKGYVNHSLSVFHTKDFQDPDGIEGSENVTLCRYRDYRNPPDYNFSEQFWFLL 699
+ +G N V + Q P RY+ R+ N + +W LL
Sbjct: 358 QGQILGRRRG-GNAGFGVEIREPLQTPQP----------RYKASRD-VGVNLALFYWKLL 405
Query: 700 A--IRLAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKYQRLREKMWHGRQRLGGV 757
A + L F+I FE+V VPD+P ++ + L + GRQ V
Sbjct: 406 AVHVHLGFIIAFENVVFFFLCPNDRLVPDVPA----LATKITARALPGQAGGGRQPGDAV 461
Query: 758 G---AGSRPPMPAH 768
AG P P H
Sbjct: 462 SVSKAGGPRPHPQH 475
>gi|169161033 PREDICTED: hypothetical protein [Homo sapiens]
Length = 723
Score = 55.8 bits (133), Expect = 1e-07
Identities = 129/549 (23%), Positives = 189/549 (34%), Gaps = 125/549 (22%)
Query: 250 SETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHWDL----------- 298
+ T + + L D GTV F+IFM+ W + A + HWD
Sbjct: 251 TNTLVWVAVEGLGDGLGTVFFSIFMSFWGHGLPGALEAGSATLAHHWDCSDFQDQEAMPS 310
Query: 299 ---YVWD----EEQEEM---ALQLINCPDYKLRPYQHSYLRSTVILVLTLLMICLMIGMA 348
+ WD ++QE M AL +C D++ + + + L +T + G+
Sbjct: 311 SAPHHWDCSDFQDQEVMPSSALHHWDCSDFQDQEECPHLQFAALALQMTQNPVT---GLK 367
Query: 349 HVLVVYRVLASALFSSSAVPFLEEQVTTAVVVTGALVHYVTIIIMTKINRCVALKLCDFE 408
S L +SSA V +V+ + H + I M V + +
Sbjct: 368 EPYFQPHSCLSHLLTSSAAILTVLCVVMIFLVSVIIYHGIISIAMFHTGNSVLMTQANVL 427
Query: 409 MPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHAS 468
++ F QF F SL++ IL R +C
Sbjct: 428 WGNGGDASMKMPSLSFSVCQFL--FFSLLH--GILQR------------------QCGPG 465
Query: 469 GCMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKCRSLRASESGHLPRDPELRDWRRNYL 528
GC + + Q+ IIM KQ L++ E++ L P PEL
Sbjct: 466 GCHIQVTQQLIIIMVGKQLLNHMEEFV---------GLGGGPGPDTPCLPEL-------- 508
Query: 529 LNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVW-LQRRL 587
Q+GF TIFV AF LAPL L +N VEI LDA K + QR +
Sbjct: 509 ------------------QFGFITIFVGAFLLAPLFTLLNNRVEIGLDAHKFLCKYQRPM 550
Query: 588 VPR---KAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKEGNSTV 644
R D W + E I +PR + R L +
Sbjct: 551 AGRGWTSGSDCSCW-RPCELI------------------LPRTNARSRLGYWLNGQGQIL 591
Query: 645 DCLKGYVNHSLSVFHTKDFQDPDGIEGSENVTLCRYRDYRNPPDYNFSEQFWFLLA--IR 702
+G N V + Q P RY+ R+ N + +W LLA +
Sbjct: 592 GRRRG-GNAGFGVEIREPLQTPQP----------RYKASRD-VGVNLALFYWKLLAVHVH 639
Query: 703 LAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKYQRLREKMWHGRQRLGGVG---A 759
L F+I FE+V VPD+P ++ + L + GRQ V A
Sbjct: 640 LGFIIAFENVVFFFLCPNDRLVPDVPA----LATKITARALPGQAGGGRQPGDAVSVSKA 695
Query: 760 GSRPPMPAH 768
G P P H
Sbjct: 696 GGPRPHPQH 704
>gi|21071070 transmembrane channel-like 1 [Homo sapiens]
Length = 760
Score = 31.2 bits (69), Expect = 3.9
Identities = 27/89 (30%), Positives = 38/89 (42%), Gaps = 18/89 (20%)
Query: 143 KDGVFEARFPLHKGEGR--------LKKTWARWRHMFR---------EQPVDEIRNYFGE 185
K V E L KG+G+ + K WA++ F E + I + FG
Sbjct: 124 KKFVSENEGALGKGKGKRWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGS 183
Query: 186 KVALYFVWLGW-YTYMLVPAALTGLLVFL 213
VA YF++L W Y +V LT L+ L
Sbjct: 184 SVASYFLFLRWMYGVNMVLFILTFSLIML 212
>gi|94536852 transmembrane cochlear-expressed protein 2 [Homo
sapiens]
Length = 906
Score = 30.8 bits (68), Expect = 5.1
Identities = 17/61 (27%), Positives = 29/61 (47%), Gaps = 17/61 (27%)
Query: 153 LHKGEGR--------LKKTWARWRHMFR---------EQPVDEIRNYFGEKVALYFVWLG 195
L KG+G+ + K W +++ F E + +I ++FG VA YF++L
Sbjct: 198 LGKGKGKQLYAYKMLMAKKWVKFKRDFDNFKTQCIPWEMKIKDIESHFGSSVASYFIFLR 257
Query: 196 W 196
W
Sbjct: 258 W 258
>gi|119943102 CREB binding protein isoform b [Homo sapiens]
Length = 2404
Score = 30.0 bits (66), Expect = 8.6
Identities = 14/47 (29%), Positives = 25/47 (53%)
Query: 31 SEQWDYVLVAQRHTQRDPRQARQQQFLEELRRKGFHIKVIRDQKQVF 77
SE DY+ Q+ P+ R Q++ +++ K F ++I D K +F
Sbjct: 1439 SEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIF 1485
>gi|119943104 CREB binding protein isoform a [Homo sapiens]
Length = 2442
Score = 30.0 bits (66), Expect = 8.6
Identities = 14/47 (29%), Positives = 25/47 (53%)
Query: 31 SEQWDYVLVAQRHTQRDPRQARQQQFLEELRRKGFHIKVIRDQKQVF 77
SE DY+ Q+ P+ R Q++ +++ K F ++I D K +F
Sbjct: 1477 SEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIF 1523
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.327 0.140 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,999,797
Number of Sequences: 37866
Number of extensions: 1241634
Number of successful extensions: 4257
Number of sequences better than 10.0: 21
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 4140
Number of HSP's gapped (non-prelim): 45
length of query: 782
length of database: 18,247,518
effective HSP length: 110
effective length of query: 672
effective length of database: 14,082,258
effective search space: 9463277376
effective search space used: 9463277376
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.