Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 14211536
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens]
(1712 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens] 3484 0.0
gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens] 3294 0.0
gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens] 1966 0.0
gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens] 1894 0.0
gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens] 1443 0.0
gi|21166382 neurexin 2 isoform beta precursor [Homo sapiens] 1172 0.0
gi|157427673 neurexin 3 isoform 3 precursor [Homo sapiens] 379 e-104
gi|21070967 neurexin 1 isoform beta precursor [Homo sapiens] 366 e-101
gi|41350305 neurexin 3 isoform 2 precursor [Homo sapiens] 331 4e-90
gi|54873613 agrin [Homo sapiens] 167 8e-41
gi|239743756 PREDICTED: hypothetical protein LOC389722 isoform 2... 166 1e-40
gi|47519929 cell recognition molecule CASPR3 [Homo sapiens] 138 4e-32
gi|116284404 cell recognition protein CASPR4 isoform 1 [Homo sap... 137 7e-32
gi|239743754 PREDICTED: hypothetical protein LOC389722 isoform 1... 135 4e-31
gi|4505463 contactin associated protein 1 precursor [Homo sapiens] 130 8e-30
gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapi... 130 8e-30
gi|18640734 contactin associated protein-like 5 [Homo sapiens] 120 1e-26
gi|148664242 cell recognition protein CASPR4 isoform 2 [Homo sap... 116 2e-25
gi|38788416 laminin, alpha 1 precursor [Homo sapiens] 116 2e-25
gi|239743797 PREDICTED: similar to cell recognition molecule CAS... 111 5e-24
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 105 5e-22
gi|33469931 EGF-like, fibronectin type III and laminin G domains... 100 2e-20
gi|33469929 EGF-like, fibronectin type III and laminin G domains... 100 2e-20
gi|33469935 EGF-like, fibronectin type III and laminin G domains... 98 6e-20
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 88 6e-17
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 87 1e-16
gi|219842266 usherin isoform B [Homo sapiens] 84 1e-15
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 82 3e-15
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 80 2e-14
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s... 79 3e-14
>gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens]
Length = 1712
Score = 3484 bits (9034), Expect = 0.0
Identities = 1712/1712 (100%), Positives = 1712/1712 (100%)
Query: 1 MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTN 60
MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTN
Sbjct: 1 MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTN 60
Query: 61 ATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRD 120
ATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRD
Sbjct: 61 ATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRD 120
Query: 121 ARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLA 180
ARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLA
Sbjct: 121 ARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLA 180
Query: 181 NLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKF 240
NLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKF
Sbjct: 181 NLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKF 240
Query: 241 CSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVATFKGNEFFCY 300
CSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVATFKGNEFFCY
Sbjct: 241 CSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVATFKGNEFFCY 300
Query: 301 DLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEAL 360
DLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEAL
Sbjct: 301 DLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEAL 360
Query: 361 VEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTM 420
VEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTM
Sbjct: 361 VEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTM 420
Query: 421 LGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQG 480
LGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQG
Sbjct: 421 LGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQG 480
Query: 481 DLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGG 540
DLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGG
Sbjct: 481 DLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGG 540
Query: 541 GAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKG 600
GAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKG
Sbjct: 541 GAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKG 600
Query: 601 SISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRD 660
SISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRD
Sbjct: 601 SISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRD 660
Query: 661 LFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTG 720
LFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTG
Sbjct: 661 LFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTG 720
Query: 721 FLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADT 780
FLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADT
Sbjct: 721 FLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADT 780
Query: 781 LRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD 840
LRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD
Sbjct: 781 LRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD 840
Query: 841 NVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGD 900
NVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGD
Sbjct: 841 NVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGD 900
Query: 901 ITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSG 960
ITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSG
Sbjct: 901 ITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSG 960
Query: 961 NGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS 1020
NGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS
Sbjct: 961 NGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS 1020
Query: 1021 RTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIA 1080
RTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIA
Sbjct: 1021 RTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIA 1080
Query: 1081 DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYI 1140
DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYI
Sbjct: 1081 DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYI 1140
Query: 1141 FGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTV 1200
FGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTV
Sbjct: 1141 FGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTV 1200
Query: 1201 GVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERL 1260
GVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERL
Sbjct: 1201 GVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERL 1260
Query: 1261 AIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKV 1320
AIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKV
Sbjct: 1261 AIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKV 1320
Query: 1321 LALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRG 1380
LALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRG
Sbjct: 1321 LALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRG 1380
Query: 1381 RSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRS 1440
RSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRS
Sbjct: 1381 RSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRS 1440
Query: 1441 PFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEV 1500
PFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEV
Sbjct: 1441 PFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEV 1500
Query: 1501 FDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNL 1560
FDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNL
Sbjct: 1501 FDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNL 1560
Query: 1561 PAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGER 1620
PAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGER
Sbjct: 1561 PAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGER 1620
Query: 1621 GPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNS 1680
GPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNS
Sbjct: 1621 GPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNS 1680
Query: 1681 AQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1712
AQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV
Sbjct: 1681 AQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1712
>gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens]
Length = 1642
Score = 3294 bits (8540), Expect = 0.0
Identities = 1641/1712 (95%), Positives = 1641/1712 (95%), Gaps = 70/1712 (4%)
Query: 1 MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTN 60
MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTN
Sbjct: 1 MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTN 60
Query: 61 ATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRD 120
ATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRD
Sbjct: 61 ATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRD 120
Query: 121 ARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLA 180
ARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLA
Sbjct: 121 ARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLA 180
Query: 181 NLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKF 240
NLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKF
Sbjct: 181 NLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKF 240
Query: 241 CSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVATFKGNEFFCY 300
CSEEEHPMEGPAHLTLNSE GKEEFVATFKGNEFFCY
Sbjct: 241 CSEEEHPMEGPAHLTLNSE------------------------GKEEFVATFKGNEFFCY 276
Query: 301 DLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEAL 360
DLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEAL
Sbjct: 277 DLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEAL 336
Query: 361 VEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTM 420
VEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMV TISVDGILTTTGYTQEDYTM
Sbjct: 337 VEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMV-------TISVDGILTTTGYTQEDYTM 389
Query: 421 LGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQG 480
LGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQG
Sbjct: 390 LGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQG 449
Query: 481 DLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGG 540
DLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGG
Sbjct: 450 DLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGG 509
Query: 541 GAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKG 600
GAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKG
Sbjct: 510 GAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKG 569
Query: 601 SISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRD 660
SISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRD
Sbjct: 570 SISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRD 629
Query: 661 LFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTG 720
LFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTG
Sbjct: 630 LFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTG 689
Query: 721 FLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADT 780
FLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADT
Sbjct: 690 FLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADT 749
Query: 781 LRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD 840
LRLELDGGQMKLTVNL KGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD
Sbjct: 750 LRLELDGGQMKLTVNL---------GKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD 800
Query: 841 NVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGD 900
NVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGD
Sbjct: 801 NVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGD 860
Query: 901 ITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSG 960
ITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSG
Sbjct: 861 ITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSG 920
Query: 961 NGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS 1020
NGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS
Sbjct: 921 NGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS 980
Query: 1021 RTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIA 1080
RTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIA
Sbjct: 981 RTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIA 1040
Query: 1081 DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYI 1140
DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYI
Sbjct: 1041 DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYI 1100
Query: 1141 FGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTV 1200
FGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTV
Sbjct: 1101 FGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTV 1160
Query: 1201 GVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERL 1260
GVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPA
Sbjct: 1161 GVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPA-------- 1212
Query: 1261 AIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKV 1320
GRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKV
Sbjct: 1213 ----------------------GRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKV 1250
Query: 1321 LALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRG 1380
LALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRG
Sbjct: 1251 LALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRG 1310
Query: 1381 RSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRS 1440
RSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRS
Sbjct: 1311 RSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRS 1370
Query: 1441 PFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEV 1500
PFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEV
Sbjct: 1371 PFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEV 1430
Query: 1501 FDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNL 1560
FDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNL
Sbjct: 1431 FDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNL 1490
Query: 1561 PAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGER 1620
PAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGER
Sbjct: 1491 PAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGER 1550
Query: 1621 GPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNS 1680
GPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNS
Sbjct: 1551 GPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNS 1610
Query: 1681 AQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1712
AQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV
Sbjct: 1611 AQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1642
>gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens]
Length = 1547
Score = 1966 bits (5093), Expect = 0.0
Identities = 975/1442 (67%), Positives = 1163/1442 (80%), Gaps = 49/1442 (3%)
Query: 14 LLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGG 73
L LLLL A GLEF G GQW R+ +W A E+SF L+T + R L+LY DD G
Sbjct: 16 LSLLLLGCWAELGSGLEFPGAEGQWTRFPKW-NACCESEMSFQLKTRSARGLVLYFDDEG 74
Query: 74 DCDFLELLLV-DGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDG-E 131
CDFLEL+L GRL+L F++ CAEPATL DTPV D WH V + R R T L +D E
Sbjct: 75 FCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVE 134
Query: 132 ARAAEVRSKRREMQVASDLFVGGIPPDVRLSAL--TLSTVKYEPPFRGLLANL------- 182
A+ EV+SKRR+M V S LFVGG+PP++R +AL TL++V+ PF+G + ++
Sbjct: 135 AKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQV 194
Query: 183 --------KLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHT 234
KL + PP G G+ + C NGG+C+V+ V CDCS T
Sbjct: 195 LPVDSGEVKLDDEPPNSGG-----GSPCEAGEEGEGGVCLNGGVCSVVDDQAV-CDCSRT 248
Query: 235 GFGGKFCSEEE------------HPMEGPAHLTLNSEVGSLLFSEGGAGRGGA----GDV 278
GF GK CS+E H + + +N+ L + G A GD
Sbjct: 249 GFRGKDCSQEIKFGLQCVLPVLLHDNDQGKYCCINT--AKPLTEKDNNVEGLAHLMMGDQ 306
Query: 279 HQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVN 338
+ +KGKEE++ATFKG+E+FCYDLS NPIQSS+DEITL+F+TLQRNGLMLHTGKSADYVN
Sbjct: 307 GK-SKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVN 365
Query: 339 LSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHY 398
L+LK+GAV LVINLGSGAFEALVEPVNGKFNDNAWHDV+VTRNLRQH+GIGHAMVNKLH
Sbjct: 366 LALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHC 425
Query: 399 LVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKN 458
VTISVDGILTTTGYTQEDYTMLGSDDFFY+GGSP+TADLPGSPVSNNFMGCLK+VVYKN
Sbjct: 426 SVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKN 485
Query: 459 NDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSIS 518
ND +LELSRLAK+GDPKMK+ G ++F+CE+VA LDP+TFE+PE+F++LP+W+AK+TGSIS
Sbjct: 486 NDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSIS 545
Query: 519 LDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRA 578
DFRTTEPNGL+LFS G+ H + D+FA+E+LDGHLYLLLDMGSG IK++A
Sbjct: 546 FDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKA 605
Query: 579 SSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVD 638
+KVNDGEW HVDFQRDGR G+ISVN+ TP+ A G+SEILDL+ ELYLGGLPE +
Sbjct: 606 LLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPEN-KAG 664
Query: 639 LPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAP 698
L P EVWTA L GYVGC+RDLFIDG+S+D+R +AE Q GV P CS+ET K C S P
Sbjct: 665 LVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNP 724
Query: 699 CRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSL 758
C+N G+CR+GWNR++CDC GTG+LGR CEREATVLSYDGSM+MKI LP MHTEAEDVSL
Sbjct: 725 CKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSL 784
Query: 759 RFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKL 818
RF SQRAYG++MATTSR+SADTLRLELD G++KLTVNLDC+R+ C SKGPETLFAG+ L
Sbjct: 785 RFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNL 844
Query: 819 NDNEWHTVRVVRRGKSLQLSVDNV-TVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSN 877
NDNEWHTVRVVRRGKSL+L+VD+ + GQMAG H RLEFHNIETGI+TERR++S VPSN
Sbjct: 845 NDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSN 904
Query: 878 FIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAY 937
FIGHL L FNG Y+D CK+GDI YCELNARFG R I+ADPVTFK++SSY+ALATLQAY
Sbjct: 905 FIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAY 964
Query: 938 ASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVN 997
SMHLFFQFKTT+ DGL+L+NSG+GNDFIV+ELVKGY+HYVFDLGNG +L+KG+S+KP+N
Sbjct: 965 TSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLN 1024
Query: 998 DNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVA 1057
DNQWHNV++SRD N+HT+KID++ TQ + GARNLDLK +LYIGG++K + +LPKLV
Sbjct: 1025 DNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVH 1084
Query: 1058 SRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDG 1117
+++GFQGCLASVDLNGRLPDLI+DAL GQ+ERGC+GPSTTC E+SC+NQGVCLQQWDG
Sbjct: 1085 AKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDG 1144
Query: 1118 FTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAV 1177
F+CDC+MTS+ GP+CNDPGTTYIF KGG ITY WPPNDRPSTR DRLA+GFST Q+ AV
Sbjct: 1145 FSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAV 1204
Query: 1178 LVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNA 1237
LVRVDS+SGLGDYL+LHI QG +GV FNVGTDDI I+E NAI++DGKYHVVRFTRSGGNA
Sbjct: 1205 LVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNA 1264
Query: 1238 TLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKI 1297
TLQVDSWPV ERYPAGN DNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQA I I
Sbjct: 1265 TLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIII 1324
Query: 1298 GGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTL 1357
GG++QG+PFQGQ+SGLYYNGLKVL +AAE+D N+ G++RLVGE PS ++ E+TAT +
Sbjct: 1325 GGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPS-SMTTESTATAM 1383
Query: 1358 LADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPST 1417
++M+T+IMETTTT+AT+T RRG+ PT ++ +Q TDD+LVASAECPSDDED++ CEPS+
Sbjct: 1384 QSEMSTSIMETTTTLATSTARRGKPPT-KEPISQTTDDILVASAECPSDDEDIDPCEPSS 1442
Query: 1418 GG 1419
GG
Sbjct: 1443 GG 1444
Score = 164 bits (416), Expect = 5e-40
Identities = 85/102 (83%), Positives = 91/102 (89%), Gaps = 1/102 (0%)
Query: 1612 ANPTGPGERGP-PGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1670
ANPT G R P PG+ EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY V
Sbjct: 1446 ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHV 1505
Query: 1671 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1712
D+SRNYISNSAQSNGAVVKEK P++ K+ +K KKNKDKEYYV
Sbjct: 1506 DESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1547
>gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens]
Length = 1477
Score = 1894 bits (4905), Expect = 0.0
Identities = 941/1426 (65%), Positives = 1128/1426 (79%), Gaps = 87/1426 (6%)
Query: 14 LLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGG 73
L LLLL A GLEF G GQW R+ +W A E+SF L+T + R L+LY DD G
Sbjct: 16 LSLLLLGCWAELGSGLEFPGAEGQWTRFPKW-NACCESEMSFQLKTRSARGLVLYFDDEG 74
Query: 74 DCDFLELLLV-DGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDG-E 131
CDFLEL+L GRL+L F++ CAEPATL DTPV D WH V + R R T L +D E
Sbjct: 75 FCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVE 134
Query: 132 ARAAEVRSKRREMQVASDLFVGGIPPDVRLSAL--TLSTVKYEPPFRGLLANL------- 182
A+ EV+SKRR+M V S LFVGG+PP++R +AL TL++V+ PF+G + ++
Sbjct: 135 AKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQV 194
Query: 183 --------KLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHT 234
KL + PP G G+ + C NGG+C+V+ V CDCS T
Sbjct: 195 LPVDSGEVKLDDEPPNSGG-----GSPCEAGEEGEGGVCLNGGVCSVVDDQAV-CDCSRT 248
Query: 235 GFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVATFKG 294
GF GK CS+E++ +EG AHL + G G+ +KGKEE++ATFKG
Sbjct: 249 GFRGKDCSQEDNNVEGLAHLMM-----------GDQGK---------SKGKEEYIATFKG 288
Query: 295 NEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGS 354
+E+FCYDLS NPIQSS+DEITL+F+TLQRNGLMLHTGKSADYVNL+LK+GAV LVINLGS
Sbjct: 289 SEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGS 348
Query: 355 GAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYT 414
GAFEALVEPVNGKFNDNAWHDV+VTRNLRQH+GIGHAMV TISVDGILTTTGYT
Sbjct: 349 GAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMV-------TISVDGILTTTGYT 401
Query: 415 QEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDP 474
QEDYTMLGSDDFFY+GGSP+TADLPGSPVSNNFMGCLK+VVYKNND +LELSRLAK+GDP
Sbjct: 402 QEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDP 461
Query: 475 KMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQ 534
KMK+ G ++F+CE+VA LDP+TFE+PE+F++LP+W+AK+TGSIS DFRTTEPNGL+LFS
Sbjct: 462 KMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSH 521
Query: 535 GRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQ 594
G+ H + D+FA+E+LDGHLYLLLDMGSG IK++A +KVNDGEW HVDFQ
Sbjct: 522 GKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQ 581
Query: 595 RDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGY 654
RDGR G+ISVN+ TP+ A G+SEILDL+ ELYLGGLPE + L P EVWTA L GY
Sbjct: 582 RDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPEN-KAGLVFPTEVWTALLNYGY 640
Query: 655 VGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFIC 714
VGC+RDLFIDG+S+D+R +AE Q GV P CS+ET K C S PC+N G+CR+GWNR++C
Sbjct: 641 VGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVC 700
Query: 715 DCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTS 774
DC GTG+LGR CEREATVLSYDGSM+MKI LP MHTEAEDVSLRF SQRAYG++MATTS
Sbjct: 701 DCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTS 760
Query: 775 RESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKS 834
R+SADTLRLELD G++KLTVNLDC+R+ C SKGPETLFAG+ LNDNEWHTVRVVRRGKS
Sbjct: 761 RDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKS 820
Query: 835 LQLSVDNV-TVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYM 893
L+L+VD+ + GQMAG H RLEFHNIETGI+TERR++S VPSNFIGHL L FNG Y+
Sbjct: 821 LKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYI 880
Query: 894 DQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDG 953
D CK+GDI YCELNARFG R I+ADPVTFK++SSY+ALATLQAY SMHLFFQFKTT+ DG
Sbjct: 881 DLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDG 940
Query: 954 LLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNV 1013
L+L+NSG+GNDFIV+ELVKGY+HYVFDLGNG +L+KG+S+KP+NDNQWHNV++SRD N+
Sbjct: 941 LILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNL 1000
Query: 1014 HTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNG 1073
HT+KID++ TQ + GARNLDLK +LYIGG++K + +LPKLV +++GFQGCLASVDLNG
Sbjct: 1001 HTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNG 1060
Query: 1074 RLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCN 1133
RLPDLI+DAL GQ+ERGC+GPSTTC E+SC+NQGVCLQQWDGF+CDC+MTS+ GP+CN
Sbjct: 1061 RLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCN 1120
Query: 1134 DPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQL 1193
DPGTTYIF KGG ITY WPPNDRPSTR DRLA+GFST Q+ AVLVRVDS+SGLGDYL+L
Sbjct: 1121 DPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLEL 1180
Query: 1194 HIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAG 1253
HI QG +GV FNVGTDDI I+E NAI++DGKYHVVRFTRSGGNATLQVDSWPV ERYPA
Sbjct: 1181 HIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPA- 1239
Query: 1254 NFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGL 1313
GRQLTIFNSQA I IGG++QG+PFQGQ+SGL
Sbjct: 1240 -----------------------------GRQLTIFNSQATIIIGGKEQGQPFQGQLSGL 1270
Query: 1314 YYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMA 1373
YYNGLKVL +AAE+D N+ G++RLVGE PS ++ E+TAT + ++M+T+IMETTTT+A
Sbjct: 1271 YYNGLKVLNMAAENDANIAIVGNVRLVGEVPS-SMTTESTATAMQSEMSTSIMETTTTLA 1329
Query: 1374 TTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGG 1419
T+T RRG+ PT ++ +Q TDD+LVASAECPSDDED++ CEPS+GG
Sbjct: 1330 TSTARRGKPPT-KEPISQTTDDILVASAECPSDDEDIDPCEPSSGG 1374
Score = 164 bits (416), Expect = 5e-40
Identities = 85/102 (83%), Positives = 91/102 (89%), Gaps = 1/102 (0%)
Query: 1612 ANPTGPGERGP-PGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1670
ANPT G R P PG+ EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY V
Sbjct: 1376 ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHV 1435
Query: 1671 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1712
D+SRNYISNSAQSNGAVVKEK P++ K+ +K KKNKDKEYYV
Sbjct: 1436 DESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1477
>gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens]
Length = 1061
Score = 1443 bits (3735), Expect = 0.0
Identities = 691/998 (69%), Positives = 821/998 (82%), Gaps = 37/998 (3%)
Query: 420 MLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQ 479
MLGSDDFFY+GGSP+TADLPGSPVSNNFMGCLK+VVYKNND +LELSRLA+ D KMK+
Sbjct: 1 MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIY 60
Query: 480 GDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAG 539
G++ F+CE+VA LDP+ FE+PEA+++LP+W+ KR GSIS DFRTTEPNGL+LF+ G+
Sbjct: 61 GEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQE 120
Query: 540 GGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRK 599
+ D+FA+ELLDG+LYLLLDMGSG IK++A+ +K NDGEW HVD QRDGR
Sbjct: 121 RKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRS 180
Query: 600 GSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVR 659
G+ISVNSR TPF A+G+SEILDLE ++YLGGLPE R L LP E+WTA L GYVGC+R
Sbjct: 181 GTISVNSRRTPFTASGESEILDLEGDMYLGGLPEN-RAGLILPTELWTAMLNYGYVGCIR 239
Query: 660 DLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGT 719
DLFIDGRS+++R LAE Q A GV CSR + KQC S PC+N VC++GWNRFICDC GT
Sbjct: 240 DLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGT 299
Query: 720 GFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESAD 779
G+ GR CEREA++LSYDGSMYMKI++P MHTEAEDVS RFMSQRAYGL++ATTSR+SAD
Sbjct: 300 GYWGRTCEREASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSAD 359
Query: 780 TLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSV 839
TLRLELDGG++KL VNLDC+R+ C SKGPETL+AG KLNDNEWHTVRVVRRGKSL+L+V
Sbjct: 360 TLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTV 419
Query: 840 DNVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDG 899
D+ EG M G H RLEFHNIETGIMTE+R+ISVVPS+FIGHL L+FNG Y+D CK+G
Sbjct: 420 DDDVAEGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNG 479
Query: 900 DITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS 959
DI YCEL ARFGLR I+ADPVTFK++SSYL+LATLQAY SMHLFFQFKTT+PDG +LFNS
Sbjct: 480 DIDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNS 539
Query: 960 GNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKID 1019
G+GNDFI +ELVKGYIHYVFDLGNGP+++KGNSD+P+NDNQWHNVV++RD N H+LK+D
Sbjct: 540 GDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVD 599
Query: 1020 SRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLI 1079
++ VTQ NGA+NLDLKG+LY+ GL++ M+SNLPKLVASRDGFQGCLASVDLNGRLPDLI
Sbjct: 600 TKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLI 659
Query: 1080 ADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTY 1139
DALHR GQ+ERGC+GPSTTC E+SCANQGVC+QQW+GFTCDC+MTSY G CNDPG TY
Sbjct: 660 NDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATY 719
Query: 1140 IFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGT 1199
IFGK G LI YTWP NDRPSTR DRLAVGFST + +LVR+DSA GLGD+LQLHI+QG
Sbjct: 720 IFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGK 779
Query: 1200 VGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNER 1259
+GV+FN+GT DI+I E V+DGKYHVVRFTR+GGNATLQVD+WPVNE YP
Sbjct: 780 IGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPT------- 832
Query: 1260 LAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLK 1319
GRQLTIFN+QA I IGG+D+GR FQGQ+SGLYY+GLK
Sbjct: 833 -----------------------GRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLK 869
Query: 1320 VLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRR 1379
VL +AAE++PN++ G +RLVGE PS+L + +T T++ +M+TT+METTTTMATTTTR+
Sbjct: 870 VLNMAAENNPNIKINGSVRLVGEVPSILGTTQT--TSMPPEMSTTVMETTTTMATTTTRK 927
Query: 1380 GRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPST 1417
RS ++ Q T D LV+SAEC SDDED ECEPST
Sbjct: 928 NRS----TASIQPTSDDLVSSAECSSDDEDFVECEPST 961
Score = 172 bits (435), Expect = 3e-42
Identities = 201/890 (22%), Positives = 347/890 (38%), Gaps = 147/890 (16%)
Query: 51 GELSFSLRTNATRALLLYL------------DDGGDCDFLELLLVDGRLRLRFTLSCAEP 98
G +SF RT L+L+ DF + L+DG L L +
Sbjct: 96 GSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTI 155
Query: 99 ATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPD 158
D W+ V + RD R ++V+ + + + D+++GG+P +
Sbjct: 156 KVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPEN 215
Query: 159 VR--LSALTLSTVKYEPPFRGLLANLKLGERPP---ALLGSQGLRGATADPLCAPARN-- 211
+ L T + G + +L + R L Q G + A+
Sbjct: 216 RAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCD 275
Query: 212 --PCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGG 269
PC N +C CDC+ TG+ G+ C E S+L +G
Sbjct: 276 SYPCKNNAVCKD-GWNRFICDCTGTGYWGRTCERE----------------ASILSYDGS 318
Query: 270 AGRGGAGDVHQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH 329
+ + + + ++++ F + + GL++
Sbjct: 319 ---------------------------MYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVA 351
Query: 330 TGK--SADYVNLSLKSGAVWLVINL--------GSGAFEALVEPVNGKFNDNAWHDVRVT 379
T SAD + L L G V L++NL S E L K NDN WH VRV
Sbjct: 352 TTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLY--AGQKLNDNEWHTVRVV 409
Query: 380 RNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLP 439
R + + ++VD + G D+T L +F I T
Sbjct: 410 RRGKS---------------LKLTVDDDV-AEGTMVGDHTRL---EFHNIETGIMTEKRY 450
Query: 440 GSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFES 499
S V ++F+G L+ +++ L L K GD + F ++ A DPVTF++
Sbjct: 451 ISVVPSSFIGHLQSLMFNG----LLYIDLCKNGDIDY-CELKARFGLRNIIA-DPVTFKT 504
Query: 500 PEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELL 559
++++L A + + F+TT P+G +LF+ G D+ A+EL+
Sbjct: 505 KSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSG-------------DGNDFIAVELV 551
Query: 560 DGHLYLLLDMGSGGIKLRASS-RKVNDGEWCHVDFQRD-GRKGSISVNSRSTPFLATGDS 617
G+++ + D+G+G ++ +S R +ND +W +V RD S+ V+++ + G +
Sbjct: 552 KGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDTKVVTQVING-A 610
Query: 618 EILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQ 677
+ LDL+ +LY+ GL +G +LP A R G+ GC+ + ++GR DL + +A
Sbjct: 611 KNLDLKGDLYMAGLAQGMYSNLPK-----LVASRDGFQGCLASVDLNGRLPDL--INDAL 663
Query: 678 GAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREAT--VLSY 735
G C C N GVC + W F CDC T + G C +
Sbjct: 664 HRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYIFGK 723
Query: 736 DGSMYMKIMLPN-AMHTEAEDVSLRFMSQRAYGLMMATTSRES-ADTLRLELDGGQMKLT 793
G + + N T ++ +++ F + G+++ S D L+L ++ G++ +
Sbjct: 724 SGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVV 783
Query: 794 VNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHM 853
N+ + + + P +ND ++H VR R G + L VDN V
Sbjct: 784 FNIGTVDISIKEERTP--------VNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQ 835
Query: 854 RLEFH---NIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGD 900
F+ I G + R F G LSGL ++G ++ + +
Sbjct: 836 LTIFNTQAQIAIGGKDKGRL-------FQGQLSGLYYDGLKVLNMAAENN 878
Score = 157 bits (396), Expect = 1e-37
Identities = 81/102 (79%), Positives = 90/102 (88%), Gaps = 1/102 (0%)
Query: 1611 TANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1670
TANPT PG R PGA EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV
Sbjct: 961 TANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1020
Query: 1671 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1712
D++RNYISNSAQSNG ++KEK ++ K+ K +KNKD+EYYV
Sbjct: 1021 DETRNYISNSAQSNGTLMKEKQQSS-KSGHKKQKNKDREYYV 1061
Score = 81.3 bits (199), Expect = 8e-15
Identities = 101/448 (22%), Positives = 177/448 (39%), Gaps = 88/448 (19%)
Query: 47 AASSGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQ--LD 104
A +S L F +T + +L+ G+ DF+ + LV G + F L P ++ D
Sbjct: 516 AYTSMHLFFQFKTTSPDGFILFNSGDGN-DFIAVELVKGYIHYVFDLGNG-PNVIKGNSD 573
Query: 105 TPVADDRWHMVLLTRDARRT-ALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSA 163
P+ D++WH V++TRD T +L VD + +V + + + + DL++ G+ + +
Sbjct: 574 RPLNDNQWHNVVITRDNSNTHSLKVDTKV-VTQVINGAKNLDLKGDLYMAGLAQGMYSNL 632
Query: 164 LTLSTVKYEPPFRGLLANLKLGERPPALLG-----SQGLRGATADPLCAPARNPCANGGL 218
L V F+G LA++ L R P L+ S + P + CAN G+
Sbjct: 633 PKL--VASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQEDSCANQGV 690
Query: 219 CTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDV 278
C G CDCS T + G C N + +F + G
Sbjct: 691 CMQQWEG-FTCDCSMTSYSGNQC---------------NDPGATYIFGKSG--------- 725
Query: 279 HQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKS---AD 335
G + + + P + +D + + F T ++G+++ + D
Sbjct: 726 ---------------GLILYTWPANDRP-STRSDRLAVGFSTTVKDGILVRIDSAPGLGD 769
Query: 336 YVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNK 395
++ L ++ G + +V N+G+ + ++ ND +H VR TRN G+A
Sbjct: 770 FLQLHIEQGKIGVVFNIGT--VDISIKEERTPVNDGKYHVVRFTRN------GGNA---- 817
Query: 396 LHYLVTISVDGILTTTGY-TQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDV 454
T+ VD Y T T+ + IGG F G L +
Sbjct: 818 -----TLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDK---------GRLFQGQLSGL 863
Query: 455 VYKNNDFKLELSRLAKEGDPKMKLQGDL 482
Y L++ +A E +P +K+ G +
Sbjct: 864 YYDG----LKVLNMAAENNPNIKINGSV 887
>gi|21166382 neurexin 2 isoform beta precursor [Homo sapiens]
Length = 666
Score = 1172 bits (3032), Expect = 0.0
Identities = 577/577 (100%), Positives = 577/577 (100%)
Query: 1136 GTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI 1195
GTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI
Sbjct: 90 GTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI 149
Query: 1196 DQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNF 1255
DQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNF
Sbjct: 150 DQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNF 209
Query: 1256 DNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYY 1315
DNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYY
Sbjct: 210 DNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYY 269
Query: 1316 NGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATT 1375
NGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATT
Sbjct: 270 NGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATT 329
Query: 1376 TTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPP 1435
TTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPP
Sbjct: 330 TTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPP 389
Query: 1436 VATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGF 1495
VATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGF
Sbjct: 390 VATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGF 449
Query: 1496 ASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSA 1555
ASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSA
Sbjct: 450 ASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSA 509
Query: 1556 PAPNLPAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPT 1615
PAPNLPAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPT
Sbjct: 510 PAPNLPAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPT 569
Query: 1616 GPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRN 1675
GPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRN
Sbjct: 570 GPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRN 629
Query: 1676 YISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1712
YISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV
Sbjct: 630 YISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 666
Score = 38.5 bits (88), Expect = 0.057
Identities = 47/208 (22%), Positives = 82/208 (39%), Gaps = 31/208 (14%)
Query: 293 KGNEFFCYDLSHNPIQSST-DEITLAFRTLQRNGLMLHTGKSA---DYVNLSLKSGAVWL 348
KG Y N S+ D + + F T QR+ +++ ++ DY+ L + G V +
Sbjct: 97 KGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGV 156
Query: 349 VINLGSGAFEALVEPVNGKFNDNAWHDVRVTR--------------NLRQHAGIGHAMVN 394
+ N+G+ + ++ N +D +H VR TR N R AG N
Sbjct: 157 IFNVGTD--DITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAG------N 208
Query: 395 KLHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDV 454
+ + I+ I G +++ +L I S + G F G + +
Sbjct: 209 FDNERLAIARQRIPYRLGRVVDEW-LLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGL 267
Query: 455 VYKNNDFKLELSRLAKEGDPKMKLQGDL 482
Y L++ LA E DP ++ +G L
Sbjct: 268 YYNG----LKVLALAAESDPNVRTEGHL 291
>gi|157427673 neurexin 3 isoform 3 precursor [Homo sapiens]
Length = 459
Score = 379 bits (973), Expect = e-104
Identities = 185/282 (65%), Positives = 227/282 (80%), Gaps = 6/282 (2%)
Query: 1136 GTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI 1195
G TYIFGK G LI YTWP NDRPSTR DRLAVGFST + +LVR+DSA GLGD+LQLHI
Sbjct: 84 GATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHI 143
Query: 1196 DQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNF 1255
+QG +GV+FN+GT DI+I E V+DGKYHVVRFTR+GGNATLQVD+WPVNE YP GN
Sbjct: 144 EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGNT 203
Query: 1256 DNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYY 1315
DNER + +Q+IP++ R V+EWL +KGRQLTIFN+QA I IGG+D+GR FQGQ+SGLYY
Sbjct: 204 DNERFQMVKQKIPFKYNRPVEEWLQEKGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYY 263
Query: 1316 NGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATT 1375
+GLKVL +AAE++PN++ G +RLVGE PS+L + +T T++ +M+TT+METTTTMATT
Sbjct: 264 DGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQT--TSMPPEMSTTVMETTTTMATT 321
Query: 1376 TTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPST 1417
TTR+ RS ++ Q T D LV+SAEC SDDED ECEPST
Sbjct: 322 TTRKNRS----TASIQPTSDDLVSSAECSSDDEDFVECEPST 359
Score = 157 bits (396), Expect = 1e-37
Identities = 81/102 (79%), Positives = 90/102 (88%), Gaps = 1/102 (0%)
Query: 1611 TANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1670
TANPT PG R PGA EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV
Sbjct: 359 TANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 418
Query: 1671 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1712
D++RNYISNSAQSNG ++KEK ++ K+ K +KNKD+EYYV
Sbjct: 419 DETRNYISNSAQSNGTLMKEKQQSS-KSGHKKQKNKDREYYV 459
Score = 45.8 bits (107), Expect = 4e-04
Identities = 30/83 (36%), Positives = 48/83 (57%), Gaps = 4/83 (4%)
Query: 946 FKTTAPDGLLL-FNSGNG-NDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHN 1003
F TT DG+L+ +S G DF+ + + +G I VF++G +K PVND ++H
Sbjct: 117 FSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIK-EERTPVNDGKYHV 175
Query: 1004 VVVSRDPGNVHTLKIDSRTVTQH 1026
V +R+ GN TL++D+ V +H
Sbjct: 176 VRFTRNGGNA-TLQVDNWPVNEH 197
Score = 39.3 bits (90), Expect = 0.033
Identities = 23/81 (28%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 50 SGELSFSLRTNATRALLLYLDDG-GDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVA 108
S L+ T +L+ +D G DFL+L + G++ + F + + + + TPV
Sbjct: 110 SDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVN 169
Query: 109 DDRWHMVLLTRDARRTALAVD 129
D ++H+V TR+ L VD
Sbjct: 170 DGKYHVVRFTRNGGNATLQVD 190
Score = 36.2 bits (82), Expect = 0.28
Identities = 18/74 (24%), Positives = 39/74 (52%), Gaps = 5/74 (6%)
Query: 311 TDEITLAFRTLQRNGLMLHTGKS---ADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGK 367
+D + + F T ++G+++ + D++ L ++ G + +V N+G+ + ++
Sbjct: 110 SDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGT--VDISIKEERTP 167
Query: 368 FNDNAWHDVRVTRN 381
ND +H VR TRN
Sbjct: 168 VNDGKYHVVRFTRN 181
Score = 34.3 bits (77), Expect = 1.1
Identities = 21/92 (22%), Positives = 44/92 (47%), Gaps = 9/92 (9%)
Query: 751 TEAEDVSLRFMSQRAYGLMMATTSRES-ADTLRLELDGGQMKLTVNLDCLRVGCAPSKGP 809
T ++ +++ F + G+++ S D L+L ++ G++ + N+ + + + P
Sbjct: 108 TRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTP 167
Query: 810 ETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDN 841
+ND ++H VR R G + L VDN
Sbjct: 168 --------VNDGKYHVVRFTRNGGNATLQVDN 191
Score = 33.5 bits (75), Expect = 1.8
Identities = 20/94 (21%), Positives = 46/94 (48%), Gaps = 11/94 (11%)
Query: 513 RTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSG 572
R+ +++ F TT +G+L+ S+ D+ + + G + ++ ++G+
Sbjct: 109 RSDRLAVGFSTTVKDGILVRID-----------SAPGLGDFLQLHIEQGKIGVVFNIGTV 157
Query: 573 GIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNS 606
I ++ VNDG++ V F R+G ++ V++
Sbjct: 158 DISIKEERTPVNDGKYHVVRFTRNGGNATLQVDN 191
>gi|21070967 neurexin 1 isoform beta precursor [Homo sapiens]
Length = 442
Score = 366 bits (940), Expect = e-101
Identities = 186/284 (65%), Positives = 221/284 (77%), Gaps = 32/284 (11%)
Query: 1136 GTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI 1195
GTTYIF KGG ITY WPPNDRPSTR DRLA+GFST Q+ AVLVRVDS+SGLGDYL+LHI
Sbjct: 88 GTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI 147
Query: 1196 DQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNF 1255
QG +GV FNVGTDDI I+E NAI++DGKYHVVRFTRSGGNATLQVDSWPV ERYPA
Sbjct: 148 HQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPA--- 204
Query: 1256 DNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYY 1315
GRQLTIFNSQA I IGG++QG+PFQGQ+SGLYY
Sbjct: 205 ---------------------------GRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYY 237
Query: 1316 NGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATT 1375
NGLKVL +AAE+D N+ G++RLVGE PS ++ E+TAT + ++M+T+IMETTTT+AT+
Sbjct: 238 NGLKVLNMAAENDANIAIVGNVRLVGEVPS-SMTTESTATAMQSEMSTSIMETTTTLATS 296
Query: 1376 TTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGG 1419
T RRG+ PT ++ +Q TDD+LVASAECPSDDED++ CEPS+GG
Sbjct: 297 TARRGKPPT-KEPISQTTDDILVASAECPSDDEDIDPCEPSSGG 339
Score = 164 bits (416), Expect = 5e-40
Identities = 85/102 (83%), Positives = 91/102 (89%), Gaps = 1/102 (0%)
Query: 1612 ANPTGPGERGP-PGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1670
ANPT G R P PG+ EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY V
Sbjct: 341 ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHV 400
Query: 1671 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1712
D+SRNYISNSAQSNGAVVKEK P++ K+ +K KKNKDKEYYV
Sbjct: 401 DESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 442
Score = 40.0 bits (92), Expect = 0.019
Identities = 42/175 (24%), Positives = 71/175 (40%), Gaps = 34/175 (19%)
Query: 312 DEITLAFRTLQRNGLMLHTGKSA---DYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKF 368
D + + F T+Q+ +++ S+ DY+ L + G + + N+G+ + +E N
Sbjct: 115 DRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTD--DIAIEESNAII 172
Query: 369 NDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGY-TQEDYTMLGSDDFF 427
ND +H VR TR+ G+A T+ VD Y T+ S
Sbjct: 173 NDGKYHVVRFTRS------GGNA---------TLQVDSWPVIERYPAGRQLTIFNSQATI 217
Query: 428 YIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDL 482
IGG G P F G L + Y L++ +A E D + + G++
Sbjct: 218 IIGGKEQ-----GQP----FQGQLSGLYYNG----LKVLNMAAENDANIAIVGNV 259
Score = 37.0 bits (84), Expect = 0.16
Identities = 37/152 (24%), Positives = 67/152 (44%), Gaps = 15/152 (9%)
Query: 751 TEAEDVSLRFMS-QRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGP 809
T A+ +++ F + Q+ L+ +S D L L + G++ + N+ + S
Sbjct: 112 TRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAI 171
Query: 810 ETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDN-VTVEGQMAGAHMRLEFHNIETGIMTER 868
+ND ++H VR R G + L VD+ +E AG + + F++ T I+ +
Sbjct: 172 --------INDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTI-FNSQATIIIGGK 222
Query: 869 RFISVVPSNFIGHLSGLVFNGQPYMDQCKDGD 900
F G LSGL +NG ++ + D
Sbjct: 223 E----QGQPFQGQLSGLYYNGLKVLNMAAEND 250
Score = 36.2 bits (82), Expect = 0.28
Identities = 22/91 (24%), Positives = 45/91 (49%), Gaps = 2/91 (2%)
Query: 546 SSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVN 605
SS+ DY + + G + + ++G+ I + S+ +NDG++ V F R G ++ V+
Sbjct: 135 SSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVD 194
Query: 606 SRST--PFLATGDSEILDLESELYLGGLPEG 634
S + A I + ++ + +GG +G
Sbjct: 195 SWPVIERYPAGRQLTIFNSQATIIIGGKEQG 225
Score = 34.7 bits (78), Expect = 0.82
Identities = 21/78 (26%), Positives = 39/78 (50%), Gaps = 1/78 (1%)
Query: 53 LSFSLRTNATRALLLYLDDG-GDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDR 111
L+ T A+L+ +D G D+LEL + G++ ++F + + A + + + D +
Sbjct: 117 LAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGK 176
Query: 112 WHMVLLTRDARRTALAVD 129
+H+V TR L VD
Sbjct: 177 YHVVRFTRSGGNATLQVD 194
>gi|41350305 neurexin 3 isoform 2 precursor [Homo sapiens]
Length = 432
Score = 331 bits (848), Expect = 4e-90
Identities = 171/283 (60%), Positives = 206/283 (72%), Gaps = 36/283 (12%)
Query: 1136 GTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI 1195
G TYIFGK G LI YTWP NDRPSTR DRLAVGFST + +LVR+DSA GLGD+LQLHI
Sbjct: 84 GATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHI 143
Query: 1196 DQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNF 1255
+QG +GV+FN+GT DI+I E V+DGKYHVVRFTR+GGNATLQVD+WPVNE YP
Sbjct: 144 EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPT--- 200
Query: 1256 DNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYY 1315
GRQLTIFN+QA I IGG+D+GR FQGQ+SGLYY
Sbjct: 201 ---------------------------GRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYY 233
Query: 1316 NGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATT 1375
+GLKVL +AAE++PN++ G +RLVGE PS+L + +T T++ +M+TT+METTTTMATT
Sbjct: 234 DGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQT--TSMPPEMSTTVMETTTTMATT 291
Query: 1376 TTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTG 1418
TTR+ RS ++ Q T D LV+SAEC SDDED ECEPSTG
Sbjct: 292 TTRKNRS----TASIQPTSDDLVSSAECSSDDEDFVECEPSTG 330
Score = 155 bits (392), Expect = 3e-37
Identities = 80/102 (78%), Positives = 90/102 (88%), Gaps = 1/102 (0%)
Query: 1611 TANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1670
+ANPT PG R PGA EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV
Sbjct: 332 SANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 391
Query: 1671 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1712
D++RNYISNSAQSNG ++KEK ++ K+ K +KNKD+EYYV
Sbjct: 392 DETRNYISNSAQSNGTLMKEKQQSS-KSGHKKQKNKDREYYV 432
Score = 50.4 bits (119), Expect = 1e-05
Identities = 36/106 (33%), Positives = 58/106 (54%), Gaps = 7/106 (6%)
Query: 946 FKTTAPDGLLL-FNSGNG-NDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHN 1003
F TT DG+L+ +S G DF+ + + +G I VF++G +K PVND ++H
Sbjct: 117 FSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIK-EERTPVNDGKYHV 175
Query: 1004 VVVSRDPGNVHTLKIDSRTVTQHSNGARNLDL---KGELYIGGLSK 1046
V +R+ GN TL++D+ V +H R L + + ++ IGG K
Sbjct: 176 VRFTRNGGNA-TLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDK 220
Score = 39.3 bits (90), Expect = 0.033
Identities = 23/81 (28%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 50 SGELSFSLRTNATRALLLYLDDG-GDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVA 108
S L+ T +L+ +D G DFL+L + G++ + F + + + + TPV
Sbjct: 110 SDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVN 169
Query: 109 DDRWHMVLLTRDARRTALAVD 129
D ++H+V TR+ L VD
Sbjct: 170 DGKYHVVRFTRNGGNATLQVD 190
Score = 38.9 bits (89), Expect = 0.043
Identities = 39/176 (22%), Positives = 72/176 (40%), Gaps = 34/176 (19%)
Query: 311 TDEITLAFRTLQRNGLMLHTGKS---ADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGK 367
+D + + F T ++G+++ + D++ L ++ G + +V N+G+ + ++
Sbjct: 110 SDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGT--VDISIKEERTP 167
Query: 368 FNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGY-TQEDYTMLGSDDF 426
ND +H VR TRN G+A T+ VD Y T T+ +
Sbjct: 168 VNDGKYHVVRFTRN------GGNA---------TLQVDNWPVNEHYPTGRQLTIFNTQAQ 212
Query: 427 FYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDL 482
IGG F G L + Y L++ +A E +P +K+ G +
Sbjct: 213 IAIGGKDK---------GRLFQGQLSGLYYDG----LKVLNMAAENNPNIKINGSV 255
Score = 36.6 bits (83), Expect = 0.22
Identities = 33/154 (21%), Positives = 64/154 (41%), Gaps = 19/154 (12%)
Query: 751 TEAEDVSLRFMSQRAYGLMMATTSRES-ADTLRLELDGGQMKLTVNLDCLRVGCAPSKGP 809
T ++ +++ F + G+++ S D L+L ++ G++ + N+ + + + P
Sbjct: 108 TRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTP 167
Query: 810 ETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHMRLEFH---NIETGIMT 866
+ND ++H VR R G + L VDN V F+ I G
Sbjct: 168 --------VNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKD 219
Query: 867 ERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGD 900
+ R F G LSGL ++G ++ + +
Sbjct: 220 KGRL-------FQGQLSGLYYDGLKVLNMAAENN 246
Score = 35.0 bits (79), Expect = 0.63
Identities = 27/124 (21%), Positives = 58/124 (46%), Gaps = 13/124 (10%)
Query: 513 RTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSG 572
R+ +++ F TT +G+L+ S+ D+ + + G + ++ ++G+
Sbjct: 109 RSDRLAVGFSTTVKDGILVRID-----------SAPGLGDFLQLHIEQGKIGVVFNIGTV 157
Query: 573 GIKLRASSRKVNDGEWCHVDFQRDGRKGSISV-NSRSTPFLATG-DSEILDLESELYLGG 630
I ++ VNDG++ V F R+G ++ V N TG I + ++++ +GG
Sbjct: 158 DISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGG 217
Query: 631 LPEG 634
+G
Sbjct: 218 KDKG 221
>gi|54873613 agrin [Homo sapiens]
Length = 2045
Score = 167 bits (423), Expect = 8e-41
Identities = 195/671 (29%), Positives = 284/671 (42%), Gaps = 104/671 (15%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRW 112
L+ R + LLLY + DFL L L+DGR++LRF PA L PV +W
Sbjct: 1396 LALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSG-PAVLTSAVPVEPGQW 1454
Query: 113 HMVLLTRDARRTALAVDGEARA-AEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKY 171
H + L+R RR L+VDGE E S + + +DLFVGG+P D +A+ L
Sbjct: 1455 HRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPED--QAAVALERTFV 1512
Query: 172 EPPFRGLL-------ANLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAP 224
RG + L+LG P A G+ G D C P NPC G C L
Sbjct: 1513 GAGLRGCIRLLDVNNQRLELGIGPGAATRGSGV-GECGDHPCLP--NPCHGGAPCQNLEA 1569
Query: 225 GEVGCDCSHTGFGGKFCSEEEHPME-GPAHLTLNSEVGSLLFSEGGA----GRGGAGDVH 279
G C C G G C++E+ P + P H V EGGA G G
Sbjct: 1570 GRFHCQCP-PGRVGPTCADEKSPCQPNPCHGAAPCRV----LPEGGAQCECPLGREGTFC 1624
Query: 280 QPTKGKE---EFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQR--NGLMLHTGK-- 332
Q G++ F+A F G H + +++ L L R +GL+L+ G+
Sbjct: 1625 QTASGQDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKT 1684
Query: 333 --SADYVNLSLKSGAVWLVINLGSGAFEALV---EPVNGKFNDNAWHDVRVTRNLRQHAG 387
D+V+L+L+ + +LG GA A++ EPV AW V + RN R+ A
Sbjct: 1685 DGKGDFVSLALRDRRLEFRYDLGKGA--AVIRSREPV----TLGAWTRVSLERNGRKGA- 1737
Query: 388 IGHAMVNKLHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLP-GSPVSNN 446
+ V G + +T+L + Y+GG+P+ + L + VS+
Sbjct: 1738 --------------LRVGDGPRVLGESPVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSG 1783
Query: 447 FMGCLKDVVYKNNDF--------KLELSRLAKEGDPKMKLQGDLSF-------RCEDVAA 491
F G ++ V +++++ A G P + G R
Sbjct: 1784 FDGAIQLVSLGGRQLLTPEHVLRQVDVTSFA--GHPCTRASGHPCLNGASCVPREAAYVC 1841
Query: 492 LDPVTFESPEAFVALPRWSAKRTGSISLDFRT--------TEPNGLLL---FSQGRRAGG 540
L P F P L SA +++ D RT TE L F R
Sbjct: 1842 LCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESEKALQSNHFELSLRTEA 1901
Query: 541 GAG----SHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRD 596
G S + +RADY A+ ++DGHL L ++GS + LR S+ VN W V R+
Sbjct: 1902 TQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLR-STVPVNTNRWLRVVAHRE 1960
Query: 597 GRKGSISVNSRSTPFLATGDSEI----LDLESELYLGGLPEGGRVDLPLPPEVWTAALRA 652
R+GS+ V + + TG S + LD + L+LGGLPE LP+ P + A
Sbjct: 1961 QREGSLQVGNEAP---VTGSSPLGATQLDTDGALWLGGLPE-----LPVGPAL-PKAYGT 2011
Query: 653 GYVGCVRDLFI 663
G+VGC+RD+ +
Sbjct: 2012 GFVGCLRDVVV 2022
Score = 89.7 bits (221), Expect = 2e-17
Identities = 75/257 (29%), Positives = 115/257 (44%), Gaps = 17/257 (6%)
Query: 887 FNGQPYMDQCKDGDITYCELNARFG---LRAIVADPVTFKSRSSYLALATLQAYASMHLF 943
F+G D G T C A G ++ PV S+LA TL+AY ++ L
Sbjct: 1339 FHGGTCQDWALGGGFT-CSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLA 1397
Query: 944 FQFKTTAPDGLLLFN-SGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWH 1002
+F+ P GLLL+N + G DF+ + L+ G + FD G+GP+++ S PV QWH
Sbjct: 1398 LEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVL--TSAVPVEPGQWH 1455
Query: 1003 NVVVSRDPGNVHTLKIDSRT--VTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRD 1060
+ +SR TL +D T + + +G L+L +L++GG+ ++ + +
Sbjct: 1456 RLELSRH-WRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGA 1514
Query: 1061 GFQGCLASVDLNGRLPDL-IADALHRIGQVERGC-DGPSTTCTEESCANQGVCLQQWDG- 1117
G +GC+ +D+N + +L I G C D P C C C G
Sbjct: 1515 GLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHP---CLPNPCHGGAPCQNLEAGR 1571
Query: 1118 FTCDCTMTSYGGPVCND 1134
F C C GP C D
Sbjct: 1572 FHCQCP-PGRVGPTCAD 1587
Score = 89.4 bits (220), Expect = 3e-17
Identities = 79/248 (31%), Positives = 116/248 (46%), Gaps = 29/248 (11%)
Query: 486 CEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSH 545
CE V FE +F+A P A T ++L+FR EP GLLL+ +
Sbjct: 1366 CEKVLGAPVPAFEG-RSFLAFPTLRAYHTLRLALEFRALEPQGLLLY------------N 1412
Query: 546 SSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVN 605
+A+ D+ A+ LLDG + L D GSG L S+ V G+W ++ R R+G++SV+
Sbjct: 1413 GNARGKDFLALALLDGRVQLRFDTGSGPAVL-TSAVPVEPGQWHRLELSRHWRRGTLSVD 1471
Query: 606 SRSTPFLATGDS--EILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFI 663
TP L S + L+L+++L++GG+PE + + L A LR GC+R L +
Sbjct: 1472 G-ETPVLGESPSGTDGLNLDTDLFVGGVPE-DQAAVALERTFVGAGLR----GCIRLLDV 1525
Query: 664 DGRSRDLR-GLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCRE-GWNRFICDCIGTGF 721
+ + +L G A GV C C PC G C+ RF C C G
Sbjct: 1526 NNQRLELGIGPGAATRGSGVGE-CGDH---PCLPNPCHGGAPCQNLEAGRFHCQC-PPGR 1580
Query: 722 LGRVCERE 729
+G C E
Sbjct: 1581 VGPTCADE 1588
Score = 86.7 bits (213), Expect = 2e-16
Identities = 119/431 (27%), Positives = 161/431 (37%), Gaps = 79/431 (18%)
Query: 41 YARWAGAASSGELSFSLRTNATRALLLYLDD--GGDCDFLELLLVDGRLRLRFTLSCAEP 98
+AR G + E+ F R LLLY G DF+ L L D RL R+ L
Sbjct: 1654 FARDLGEKMALEVVFLAR--GPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGA- 1710
Query: 99 ATLQLDTPVADDRWHMVLLTRDARRTALAV-DGEARAAEVRSKRREMQVASDLFVGGIPP 157
A ++ PV W V L R+ R+ AL V DG E + + L+VGG P
Sbjct: 1711 AVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPVPHTVLNLKEPLYVGGAPD 1770
Query: 158 DVRLSALTLSTVKYEPPFRGLLANLKLGER----PPALLGSQGLRGATADPLCAPARNPC 213
+L+ F G + + LG R P +L + P + +PC
Sbjct: 1771 FSKLAR----AAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPC 1826
Query: 214 ANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRG 273
NG C V C C GF G C E G
Sbjct: 1827 LNGASCVPREAAYV-CLCPG-GFSGPHC-------------------------EKGLVEK 1859
Query: 274 GAGDVHQPTKGKEEFVATFKGNEFFCY----DLSHNPIQSSTDEITLAFRTLQRNGLMLH 329
AGDV F G F Y S +QS+ E++L RT GL+L
Sbjct: 1860 SAGDVD---------TLAFDGRTFVEYLNAVTESEKALQSNHFELSL--RTEATQGLVLW 1908
Query: 330 TGKS---ADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHA 386
+GK+ ADYV L++ G + L NLGS + +V N N W +RV + Q
Sbjct: 1909 SGKATERADYVALAIVDGHLQLSYNLGS---QPVVLRSTVPVNTNRW--LRVVAHREQRE 1963
Query: 387 GIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSP--VS 444
G ++ V TG + T L +D ++GG P P P
Sbjct: 1964 G-------------SLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYG 2010
Query: 445 NNFMGCLKDVV 455
F+GCL+DVV
Sbjct: 2011 TGFVGCLRDVV 2021
Score = 83.6 bits (205), Expect = 2e-15
Identities = 84/342 (24%), Positives = 142/342 (41%), Gaps = 50/342 (14%)
Query: 516 SISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIK 575
++ + F P+GLLL++ + G G D+ ++ L D L D+G G
Sbjct: 1663 ALEVVFLARGPSGLLLYNGQKTDGKG----------DFVSLALRDRRLEFRYDLGKGAAV 1712
Query: 576 LRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDS----EILDLESELYLGGL 631
+R S V G W V +R+GRKG++ V G+S +L+L+ LY+GG
Sbjct: 1713 IR-SREPVTLGAWTRVSLERNGRKGALRVGDGPR---VLGESPVPHTVLNLKEPLYVGGA 1768
Query: 632 PEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETL 691
P+ ++ AA+ +G+ G ++ + + G R L V V F
Sbjct: 1769 PDFSKL-------ARAAAVSSGFDGAIQLVSLGG--RQLLTPEHVLRQVDVTSFAGHPCT 1819
Query: 692 KQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCER--------EATVLSYDGSM---Y 740
+ + PC NG C ++C C G GF G CE+ + L++DG Y
Sbjct: 1820 R-ASGHPCLNGASCVPREAAYVCLCPG-GFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEY 1877
Query: 741 MKIMLPNAMHTEAEDVSLRFMSQRAYGLMM-ATTSRESADTLRLELDGGQMKLTVNLDCL 799
+ + + ++ L ++ GL++ + + E AD + L + G ++L+ NL
Sbjct: 1878 LNAVTESEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNL--- 1934
Query: 800 RVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDN 841
P L + +N N W V R + L V N
Sbjct: 1935 ------GSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGN 1970
Score = 68.9 bits (167), Expect = 4e-11
Identities = 85/347 (24%), Positives = 137/347 (39%), Gaps = 29/347 (8%)
Query: 927 SYLALATLQAYA-----SMHLFFQFKTTAPDGLLLFNS----GNGNDFIVIELVKGYIHY 977
S+L L L +A M L F P GLLL+N G G DF+ + L + +
Sbjct: 1644 SHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKG-DFVSLALRDRRLEF 1702
Query: 978 VFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS--RTVTQHSNGARNLDL 1035
+DLG G ++++ S +PV W V + R+ G L++ R + + L+L
Sbjct: 1703 RYDLGKGAAVIR--SREPVTLGAWTRVSLERN-GRKGALRVGDGPRVLGESPVPHTVLNL 1759
Query: 1036 KGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDG 1095
K LY+GG FS L + A GF G + V L GR L + + R V
Sbjct: 1760 KEPLYVGGAPD--FSKLARAAAVSSGFDGAIQLVSLGGR-QLLTPEHVLRQVDVTSFAGH 1816
Query: 1096 PSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFG-------KGGALI 1148
P T + C N C+ + + C C + GP C G G +
Sbjct: 1817 PCTRASGHPCLNGASCVPREAAYVCLCP-GGFSGPHCEKGLVEKSAGDVDTLAFDGRTFV 1875
Query: 1149 TY-TWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVG 1207
Y + + + + T +++ A+ DY+ L I G + + +N+G
Sbjct: 1876 EYLNAVTESEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLG 1935
Query: 1208 TDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQV-DSWPVNERYPAG 1253
+ + + V+ ++ V R +LQV + PV P G
Sbjct: 1936 SQPVVL-RSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLG 1981
Score = 57.8 bits (138), Expect = 9e-08
Identities = 51/170 (30%), Positives = 76/170 (44%), Gaps = 17/170 (10%)
Query: 47 AASSGELSFSLRTNATRALLLYLDDGGD-CDFLELLLVDGRLRLRFTLSCAEPATLQLDT 105
A S SLRT AT+ L+L+ + D++ L +VDG L+L + L ++P L+
Sbjct: 1887 ALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLG-SQPVVLRSTV 1945
Query: 106 PVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASD--LFVGGIPPDVRLSA 163
PV +RW V+ R+ R +L V EA S Q+ +D L++GG+P L
Sbjct: 1946 PVNTNRWLRVVAHREQREGSLQVGNEAPVTG-SSPLGATQLDTDGALWLGGLP---ELPV 2001
Query: 164 LTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGATADPLCAPARNPC 213
Y F G L ++ +G P LL D + P PC
Sbjct: 2002 GPALPKAYGTGFVGCLRDVVVGRHPLHLL---------EDAVTKPELRPC 2042
Score = 56.6 bits (135), Expect = 2e-07
Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 18/168 (10%)
Query: 681 GVAPFCSRETLKQCASAPCRNGGVCREGW---NRFICDCIGTGFLGRVCER--EATVLSY 735
G P ++ K C S PC +GG C++ W F C C G G VCE+ A V ++
Sbjct: 1320 GRRPPAPQQPPKPCDSQPCFHGGTCQD-WALGGGFTCSC-PAGRGGAVCEKVLGAPVPAF 1377
Query: 736 DGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVN 795
+G ++ A HT ++L F + GL++ + D L L L G+++L +
Sbjct: 1378 EGRSFLAFPTLRAYHTLR--LALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFD 1435
Query: 796 LDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVT 843
GP L + + +WH + + R + LSVD T
Sbjct: 1436 ---------TGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGET 1474
Score = 33.1 bits (74), Expect = 2.4
Identities = 20/60 (33%), Positives = 25/60 (41%), Gaps = 5/60 (8%)
Query: 1085 RIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFT--CDCTMTSYGGP---VCNDPGTTY 1139
RI + RG G C+ +C+ C + DG T C C T G P VC G Y
Sbjct: 233 RIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADY 292
>gi|239743756 PREDICTED: hypothetical protein LOC389722 isoform 2
[Homo sapiens]
Length = 1207
Score = 166 bits (421), Expect = 1e-40
Identities = 196/801 (24%), Positives = 319/801 (39%), Gaps = 114/801 (14%)
Query: 289 VATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHT-GKSADYVNLSLKSGAVW 347
V F G Y L P++ D I+L F+ +Q NG++LH G+ +++ L L G +
Sbjct: 183 VVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHGNHITLELIKGKLV 242
Query: 348 LVINLGSGAFEALVEPVN----GKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTIS 403
+N G+ + + PV +D WH V ++ L V +
Sbjct: 243 FFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSV---------------LIELLDTQVNFT 287
Query: 404 VDGILTTTGYTQEDYTMLGSDDFFYIGG--SPNTADLPGSPVSNNFMGCLKDVVYKNNDF 461
VD T + D + L + GG SP + + +F GCL+++ Y D
Sbjct: 288 VDKH-THHFQAKGDSSNLDLNFEISFGGILSPGRSR---AFTRKSFHGCLENLYYNGVD- 342
Query: 462 KLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDF 521
++ LAK+ P++ + G++SF C + PVTF S +++ALP S + S++ F
Sbjct: 343 ---VTELAKKHKPQILMMGNVSFSCPQPQTV-PVTFLSSRSYLALPGNSGEDKVSVTFQF 398
Query: 522 RTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSR 581
RT G LLF + +R G F + L DG L L L + +
Sbjct: 399 RTWNRAGHLLFGELQRGSGS------------FVLFLKDGKLKLSLFQAGQSPRNVTAGA 446
Query: 582 KVNDGEWCHVDFQRDGRKGSISVNSRST--PFLATGDSEILDLESELYLGGL---PEGGR 636
+NDG+W V F ++ V+ + P +A ++D Y GG G
Sbjct: 447 GLNDGQWHSVSFSAKWSHMNVVVDDDTAVQPLVAV----LIDSGDTYYFGGCLGNSSGSG 502
Query: 637 VDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGV---APFCSRETLKQ 693
PL G+ GC+R + I ++ D + QGA+G S +
Sbjct: 503 CKSPL----------GGFQGCLRLITIGDKAVD--PILVQQGALGSFRDLQIDSCGITDR 550
Query: 694 CASAPCRNGGVCREGWNRFICDCIGTGFLGRVCERE-----------------ATVLSYD 736
C + C +GG C + W+ F CDC+GTG+ G C + D
Sbjct: 551 CLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCHSSLYEQSCEAHKHRGNPSGLYYIDAD 610
Query: 737 GSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRE-SADTLRLELDGGQMKLTVN 795
GS + L T++ +R A L A + SA + GQ++ VN
Sbjct: 611 GSGPLGPFLVYCNMTDSAWTVVRHGGPDAVTLRGAPSGHPLSAVSFAYAAGAGQLRAAVN 670
Query: 796 LD-------CLRVGCA--PSKGPETLFAGHKLNDNEWHTV--RVVRRGKSLQLSVDNVTV 844
L LR G A P T + NE HT + + ++ +
Sbjct: 671 LAERCEQRLALRCGTARRPDSRDGTPLSWWVGRTNETHTSWGGSLPDAQKCTCGLEGNCI 730
Query: 845 EGQ-MAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITY 903
+ Q +T +++++ + V + GQP+ + D T
Sbjct: 731 DSQYYCNCDAGQNEWTSDTIVLSQKEHLPVTQ-------IVMTDTGQPH----SEADYTL 779
Query: 904 CELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGN 963
L R G ++ + +F + +SYL + + F FKTT G+ + N G
Sbjct: 780 GPLLCR-GDKSF-WNSASFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI-T 836
Query: 964 DFIVIEL-VKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRD--PGNVHTLKIDS 1020
DFI IEL + + FD+GNGP + S P NDNQWH+V R+ ++ ++
Sbjct: 837 DFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQ 896
Query: 1021 RTVTQHSNGARNLDLKGELYI 1041
+ ++G L L +L+I
Sbjct: 897 KMQPAPADGHVRLQLNSQLFI 917
Score = 115 bits (289), Expect = 3e-25
Identities = 113/418 (27%), Positives = 176/418 (42%), Gaps = 20/418 (4%)
Query: 726 CEREATVLSYDGSMYMKIMLPNAMHTEAEDV-SLRFMSQRAYGLMMATTSRESADTLRLE 784
C ++ V+ +DG + L DV SL+F + ++ G+++ + + + LE
Sbjct: 177 CAYKSEVVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHG-NHITLE 235
Query: 785 LDGGQMKLTVNLDCLRVGCAPSK-GPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVT 843
L G++ +N ++ PS P TL G L+D WH+V + + +VD T
Sbjct: 236 LIKGKLVFFLNSGNAKL---PSTIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHT 292
Query: 844 VEGQMAG--AHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDI 901
Q G +++ L F GI++ R + +F G L L +NG + K
Sbjct: 293 HHFQAKGDSSNLDLNFEISFGGILSPGRSRAFTRKSFHGCLENLYYNGVDVTELAKKHKP 352
Query: 902 TYCEL-NARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS- 959
+ N F PVTF S SYLAL + + FQF+T G LLF
Sbjct: 353 QILMMGNVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFGEL 412
Query: 960 GNGNDFIVIELVKGYIHY-VFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKI 1018
G+ V+ L G + +F G P + + +ND QWH+V S +++ + +
Sbjct: 413 QRGSGSFVLFLKDGKLKLSLFQAGQSPRNVTAGAG--LNDGQWHSVSFSAKWSHMNVV-V 469
Query: 1019 DSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDL 1078
D T Q +D Y GG N + K + GFQGCL + + + D
Sbjct: 470 DDDTAVQPLVAVL-IDSGDTYYFGGCLGNSSGSGCK--SPLGGFQGCLRLITIGDKAVDP 526
Query: 1079 IA---DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCN 1133
I AL ++ G + C C + G C Q WD F+CDC T Y G C+
Sbjct: 527 ILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCH 584
Score = 38.9 bits (89), Expect = 0.043
Identities = 45/175 (25%), Positives = 74/175 (42%), Gaps = 21/175 (12%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVD-GRLRLRFTLSCAE-PATLQLDTP-VAD 109
++ S RT + +LLLY+ + ++L ++L + G L++R+ L + P D +AD
Sbjct: 961 ITLSFRTTRSPSLLLYVSSFYE-EYLSVILANNGSLQIRYKLDRHQNPDAFTFDFKNMAD 1019
Query: 110 DRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVG------GIPPDVRLSA 163
+ H V + R+ + V+ A+ + S E L +G G PD R +A
Sbjct: 1020 GQLHQVKINREEAVVMVEVNQSAKKQVILSSGTEFNAVKSLILGKVLEAAGADPDTRRAA 1079
Query: 164 LTLSTVKYEPPFRGLLANLKLGERPP--ALLGSQGLRGATADPLCAPARNPCANG 216
+ F G L+ ++ G P A L G T AP CA G
Sbjct: 1080 TS--------GFTGCLSAVRFGRAAPLKAALRPSGPSRVTVRGHVAPMAR-CAAG 1125
Score = 37.4 bits (85), Expect = 0.13
Identities = 51/237 (21%), Positives = 86/237 (36%), Gaps = 23/237 (9%)
Query: 49 SSGE----LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLD 104
+SGE ++F RT LL+ + L L DG+L+L + P +
Sbjct: 386 NSGEDKVSVTFQFRTWNRAGHLLFGELQRGSGSFVLFLKDGKLKLSLFQAGQSPRNVTAG 445
Query: 105 TPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSAL 164
+ D +WH V + + VD + + + + + GG + S
Sbjct: 446 AGLNDGQWHSVSFSAKWSHMNVVVDDDTAVQPLVAVL--IDSGDTYYFGGCLGNSSGSGC 503
Query: 165 TLSTVKYEPPFRGLLANLKLGERP-PALLGSQGLRGATAD---------PLCAPARNPCA 214
F+G L + +G++ +L QG G+ D C P+ C
Sbjct: 504 KSPL----GGFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDRCLPSY--CE 557
Query: 215 NGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAG 271
+GG C+ + CDC TG+ G+ C + AH + G G+G
Sbjct: 558 HGGECSQ-SWDTFSCDCLGTGYTGETCHSSLYEQSCEAHKHRGNPSGLYYIDADGSG 613
Score = 32.3 bits (72), Expect = 4.1
Identities = 27/105 (25%), Positives = 41/105 (39%), Gaps = 9/105 (8%)
Query: 78 LELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEV 137
L L G +L T++ P TL L + + D WH VL+ + VD +
Sbjct: 241 LVFFLNSGNAKLPSTIA---PVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHTHHFQA 297
Query: 138 RSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANL 182
+ + + ++ GGI R A T + F G L NL
Sbjct: 298 KGDSSNLDLNFEISFGGILSPGRSRAFTRKS------FHGCLENL 336
Score = 32.0 bits (71), Expect = 5.3
Identities = 25/83 (30%), Positives = 43/83 (51%), Gaps = 5/83 (6%)
Query: 1186 GLGDYLQLHIDQGT-VGVIFNVGTD--DITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1242
G+ D++++ + T V F+VG ++T+ P +D ++H VR R+ A+LQVD
Sbjct: 834 GITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPF-NDNQWHHVRAERNVKGASLQVD 892
Query: 1243 SWPVNERYPAGNFDNERLAIARQ 1265
P + PA + RL + Q
Sbjct: 893 QLP-QKMQPAPADGHVRLQLNSQ 914
>gi|47519929 cell recognition molecule CASPR3 [Homo sapiens]
Length = 1288
Score = 138 bits (348), Expect = 4e-32
Identities = 122/454 (26%), Positives = 193/454 (42%), Gaps = 69/454 (15%)
Query: 289 VATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHT-GKSADYVNLSLKSGAVW 347
V F G Y L P++ D I+L F+ +Q NG++LH G+ +++ L L G +
Sbjct: 183 VVYFDGQSALLYRLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHGNHITLELIKGKLV 242
Query: 348 LVINLGSGAFEALVEPVN----GKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTIS 403
+N G+ + + PV +D WH V ++ L V +
Sbjct: 243 FFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSV---------------LIELLDTQVNFT 287
Query: 404 VDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVS---NNFMGCLKDVVYKNND 460
VD T + D + L + GG P PG + +F GCL+++ Y D
Sbjct: 288 VDKH-THHFQAKGDSSYLDLNFEISFGGIPT----PGRSRAFRRKSFHGCLENLYYNGVD 342
Query: 461 FKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLD 520
++ LAK+ P++ + G++SF C + PVTF S +++ALP S + S++
Sbjct: 343 ----VTELAKKHKPQILMMGNVSFSCPQPQTV-PVTFLSSRSYLALPGNSGEDKVSVTFQ 397
Query: 521 FRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASS 580
FRT G LLF + RR G F + L DG L L L + +
Sbjct: 398 FRTWNRAGHLLFGELRRGSGS------------FVLFLKDGKLKLSLFQPGQSPRNVTAG 445
Query: 581 RKVNDGEWCHVDFQRDGRKGSISVNSRST--PFLATGDSEILDLESELYLGGLPE---GG 635
+NDG+W V F ++ V+ + P +A ++D Y GG + G
Sbjct: 446 AGLNDGQWHSVSFSAKWSHMNVVVDDDTAVQPLVAV----LIDSGDTYYFGGCLDNSSGS 501
Query: 636 RVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGV---APFCSRETLK 692
PL G+ GC+R + I ++ D + QGA+G S
Sbjct: 502 GCKSPL----------GGFQGCLRLITIGDKAVD--PILVQQGALGSFRDLQIDSCGITD 549
Query: 693 QCASAPCRNGGVCREGWNRFICDCIGTGFLGRVC 726
+C + C +GG C + W+ F CDC+GTG+ G C
Sbjct: 550 RCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETC 583
Score = 114 bits (286), Expect = 6e-25
Identities = 114/418 (27%), Positives = 175/418 (41%), Gaps = 20/418 (4%)
Query: 726 CEREATVLSYDGSMYMKIMLPNAMHTEAEDV-SLRFMSQRAYGLMMATTSRESADTLRLE 784
C ++ V+ +DG + L DV SL+F + ++ G+++ + + + LE
Sbjct: 177 CAYKSEVVYFDGQSALLYRLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHG-NHITLE 235
Query: 785 LDGGQMKLTVNLDCLRVGCAPSK-GPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVT 843
L G++ +N ++ PS P TL G L+D WH+V + + +VD T
Sbjct: 236 LIKGKLVFFLNSGNAKL---PSTIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHT 292
Query: 844 VEGQMAG--AHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDI 901
Q G +++ L F GI T R + +F G L L +NG + K
Sbjct: 293 HHFQAKGDSSYLDLNFEISFGGIPTPGRSRAFRRKSFHGCLENLYYNGVDVTELAKKHKP 352
Query: 902 TYCEL-NARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS- 959
+ N F PVTF S SYLAL + + FQF+T G LLF
Sbjct: 353 QILMMGNVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFGEL 412
Query: 960 GNGNDFIVIELVKGYIHY-VFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKI 1018
G+ V+ L G + +F G P + + +ND QWH+V S +++ + +
Sbjct: 413 RRGSGSFVLFLKDGKLKLSLFQPGQSPRNVTAGAG--LNDGQWHSVSFSAKWSHMNVV-V 469
Query: 1019 DSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDL 1078
D T Q +D Y GG N + K + GFQGCL + + + D
Sbjct: 470 DDDTAVQPLVAVL-IDSGDTYYFGGCLDNSSGSGCK--SPLGGFQGCLRLITIGDKAVDP 526
Query: 1079 IA---DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCN 1133
I AL ++ G + C C + G C Q WD F+CDC T Y G C+
Sbjct: 527 ILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCH 584
Score = 111 bits (278), Expect = 5e-24
Identities = 99/345 (28%), Positives = 159/345 (46%), Gaps = 43/345 (12%)
Query: 921 TFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIEL-VKGYIHYVF 979
+F + +SYL + + F FKTT G+ + N G DFI IEL + + F
Sbjct: 796 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI-TDFIRIELRAPTEVTFSF 854
Query: 980 DLGNGPSLMKGNSDKPVNDNQWHNVVVSRD--PGNVHTLKIDSRTVTQHSNGARNLDLKG 1037
D+GNGP + S P NDNQWH+V R+ ++ ++ + ++G L L
Sbjct: 855 DVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNS 914
Query: 1038 ELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPS 1097
+L+IGG + + GF GC+ S+ LNG DL A G VE GC G
Sbjct: 915 QLFIGGTA-----------TRQRGFLGCIRSLQLNGVALDLEERATVTPG-VEPGCAGHC 962
Query: 1098 TTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALI-----TYTW 1152
+T C N G C ++ G TCDC ++Y GP C++ + Y F G ++ YT
Sbjct: 963 ST-YGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEISAY-FATGSSMTYHFQEHYTL 1020
Query: 1153 PPN----------DRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI-DQGTVG 1201
N D TR + + + F T + ++L+ V +S +YL + + + G++
Sbjct: 1021 SENSSSLVSSLHRDVTLTR-EMITLSFRTTRTPSLLLYV--SSFYEEYLSVILANNGSLQ 1077
Query: 1202 VIFNV----GTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1242
+ + + D T D N ++DG+ H V+ R ++V+
Sbjct: 1078 IRYKLDRHQNPDAFTFDFKN--MADGQLHQVKINREEAVVMVEVN 1120
Score = 76.6 bits (187), Expect = 2e-13
Identities = 84/380 (22%), Positives = 153/380 (40%), Gaps = 68/380 (17%)
Query: 488 DVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSS 547
D + + +F + +++ P + + T + F+TT +G+ + + G
Sbjct: 788 DQSFWNSASFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI----------- 836
Query: 548 AQRADYFAMEL-LDGHLYLLLDMGSGGIKLRASS-RKVNDGEWCHVDFQRDGRKGSISVN 605
D+ +EL + D+G+G ++ S ND +W HV +R+ + S+ V+
Sbjct: 837 ---TDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVD 893
Query: 606 S---RSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLF 662
+ P A G L L S+L++GG TA + G++GC+R L
Sbjct: 894 QLPQKMQPAPADGHVR-LQLNSQLFIGG----------------TATRQRGFLGCIRSLQ 936
Query: 663 IDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAP--CRNGGVCREGWNRFICDCIGTG 720
++G + DL A GV P C+ C++ CRNGG CRE CDC +
Sbjct: 937 LNGVALDLEERATV--TPGVEPGCAGH----CSTYGHLCRNGGRCREKRRGVTCDCAFSA 990
Query: 721 FLGRVCEREATVLSYDGSMYM------------KIMLPNAMHTEA----EDVSLRFMSQR 764
+ G C E + GS L +++H + E ++L F + R
Sbjct: 991 YDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSSLHRDVTLTREMITLSFRTTR 1050
Query: 765 AYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETL-FAGHKLNDNEW 823
L++ +S + + G +++ LD + P+ F + D +
Sbjct: 1051 TPSLLLYVSSFYEEYLSVILANNGSLQIRYKLD-------RHQNPDAFTFDFKNMADGQL 1103
Query: 824 HTVRVVRRGKSLQLSVDNVT 843
H V++ R + + V+ T
Sbjct: 1104 HQVKINREEAVVMVEVNQST 1123
Score = 50.8 bits (120), Expect = 1e-05
Identities = 57/240 (23%), Positives = 92/240 (38%), Gaps = 56/240 (23%)
Query: 100 TLQLDTPVADDRWHMVLLTRDARRTALAVD--GEARAAEVRSKRREMQVASDLFVGGIPP 157
T+Q TP D++WH V R+ + +L VD + +Q+ S LF+GG
Sbjct: 864 TVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGG--- 920
Query: 158 DVRLSALTLSTVKYEPPFRGLLANLKLG-------ERPPALLGSQ-GLRGATADPLCAPA 209
T + F G + +L+L ER G + G G C+
Sbjct: 921 ----------TATRQRGFLGCIRSLQLNGVALDLEERATVTPGVEPGCAGH-----CSTY 965
Query: 210 RNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGG 269
+ C NGG C G V CDC+ + + G FCS E S F+ G
Sbjct: 966 GHLCRNGGRCREKRRG-VTCDCAFSAYDGPFCSNEI----------------SAYFATGS 1008
Query: 270 AGRGGAGDVHQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH 329
+ + + ++ V++ H + + + ITL+FRT + L+L+
Sbjct: 1009 SMTYHFQEHYTLSENSSSLVSSL-----------HRDVTLTREMITLSFRTTRTPSLLLY 1057
Score = 45.8 bits (107), Expect = 4e-04
Identities = 93/389 (23%), Positives = 147/389 (37%), Gaps = 78/389 (20%)
Query: 748 AMHTE-AEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPS 806
A H E DV F + + G+ M D +R+EL ++T + D VG P
Sbjct: 808 AFHGELTADVCFFFKTTVSSGVFMENLG--ITDFIRIELRA-PTEVTFSFD---VGNGPC 861
Query: 807 KGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGA--HMRLEFHN--IET 862
+ T+ + NDN+WH VR R K L VD + + Q A A H+RL+ ++
Sbjct: 862 E--VTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIG 919
Query: 863 GIMTERRFISVVPSNFIGHLSGLVFNG-----------QPYMDQ-CKDGDITYCEL---- 906
G T +R F+G + L NG P ++ C TY L
Sbjct: 920 GTATRQR-------GFLGCIRSLQLNGVALDLEERATVTPGVEPGCAGHCSTYGHLCRNG 972
Query: 907 -NARFGLRAIVAD--------PVTFKSRSSYLALATLQAY----------------ASMH 941
R R + D P S+Y A + Y +S+H
Sbjct: 973 GRCREKRRGVTCDCAFSAYDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSSLH 1032
Query: 942 ---------LFFQFKTTAPDGLLLFNSGNGNDFIVIELVKG---YIHYVFDLGNGPSLMK 989
+ F+TT LLL+ S +++ + L I Y D P
Sbjct: 1033 RDVTLTREMITLSFRTTRTPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFT 1092
Query: 990 GNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQ--HSNGARNLDLKGELYIGGLSKN 1047
+ K + D Q H V ++R+ V ++++ T Q S+G +K L +G + +
Sbjct: 1093 FDF-KNMADGQLHQVKINREEA-VVMVEVNQSTKKQVILSSGTEFNAVK-SLILGKVLEA 1149
Query: 1048 MFSNLPKLVASRDGFQGCLASVDLNGRLP 1076
++ A+ GF GCL++V P
Sbjct: 1150 AGADPDTRRAATSGFTGCLSAVRFGRAAP 1178
Score = 40.0 bits (92), Expect = 0.019
Identities = 21/74 (28%), Positives = 38/74 (51%), Gaps = 2/74 (2%)
Query: 311 TDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGA-VWLVINLGSGAFEALVEPVNGKFN 369
T ++ F+T +G+ + D++ + L++ V ++G+G E V+ FN
Sbjct: 814 TADVCFFFKTTVSSGVFMENLGITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPT-PFN 872
Query: 370 DNAWHDVRVTRNLR 383
DN WH VR RN++
Sbjct: 873 DNQWHHVRAERNVK 886
Score = 38.9 bits (89), Expect = 0.043
Identities = 45/175 (25%), Positives = 73/175 (41%), Gaps = 21/175 (12%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVD-GRLRLRFTLSCAE-PATLQLDTP-VAD 109
++ S RT T +LLLY+ + ++L ++L + G L++R+ L + P D +AD
Sbjct: 1042 ITLSFRTTRTPSLLLYVSSFYE-EYLSVILANNGSLQIRYKLDRHQNPDAFTFDFKNMAD 1100
Query: 110 DRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVG------GIPPDVRLSA 163
+ H V + R+ + V+ + + S E L +G G PD R +A
Sbjct: 1101 GQLHQVKINREEAVVMVEVNQSTKKQVILSSGTEFNAVKSLILGKVLEAAGADPDTRRAA 1160
Query: 164 LTLSTVKYEPPFRGLLANLKLGERPP--ALLGSQGLRGATADPLCAPARNPCANG 216
+ F G L+ ++ G P A L G T AP CA G
Sbjct: 1161 TS--------GFTGCLSAVRFGRAAPLKAALRPSGPSRVTVRGHVAPMAR-CAAG 1206
Score = 37.0 bits (84), Expect = 0.16
Identities = 51/237 (21%), Positives = 85/237 (35%), Gaps = 23/237 (9%)
Query: 49 SSGE----LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLD 104
+SGE ++F RT LL+ + L L DG+L+L P +
Sbjct: 386 NSGEDKVSVTFQFRTWNRAGHLLFGELRRGSGSFVLFLKDGKLKLSLFQPGQSPRNVTAG 445
Query: 105 TPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSAL 164
+ D +WH V + + VD + + + + + GG + S
Sbjct: 446 AGLNDGQWHSVSFSAKWSHMNVVVDDDTAVQPLVAVL--IDSGDTYYFGGCLDNSSGSGC 503
Query: 165 TLSTVKYEPPFRGLLANLKLGERP-PALLGSQGLRGATAD---------PLCAPARNPCA 214
F+G L + +G++ +L QG G+ D C P+ C
Sbjct: 504 KSPL----GGFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDRCLPSY--CE 557
Query: 215 NGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAG 271
+GG C+ + CDC TG+ G+ C + AH + G G+G
Sbjct: 558 HGGECS-QSWDTFSCDCLGTGYTGETCHSSLYEQSCEAHKHRGNPSGLYYIDADGSG 613
Score = 33.1 bits (74), Expect = 2.4
Identities = 27/105 (25%), Positives = 41/105 (39%), Gaps = 9/105 (8%)
Query: 78 LELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEV 137
L L G +L T++ P TL L + + D WH VL+ + VD +
Sbjct: 241 LVFFLNSGNAKLPSTIA---PVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHTHHFQA 297
Query: 138 RSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANL 182
+ + + ++ GGIP R A + F G L NL
Sbjct: 298 KGDSSYLDLNFEISFGGIPTPGRSRAFRRKS------FHGCLENL 336
Score = 32.0 bits (71), Expect = 5.3
Identities = 25/83 (30%), Positives = 43/83 (51%), Gaps = 5/83 (6%)
Query: 1186 GLGDYLQLHIDQGT-VGVIFNVGTD--DITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1242
G+ D++++ + T V F+VG ++T+ P +D ++H VR R+ A+LQVD
Sbjct: 835 GITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPF-NDNQWHHVRAERNVKGASLQVD 893
Query: 1243 SWPVNERYPAGNFDNERLAIARQ 1265
P + PA + RL + Q
Sbjct: 894 QLP-QKMQPAPADGHVRLQLNSQ 915
>gi|116284404 cell recognition protein CASPR4 isoform 1 [Homo
sapiens]
Length = 1308
Score = 137 bits (346), Expect = 7e-32
Identities = 117/452 (25%), Positives = 191/452 (42%), Gaps = 63/452 (13%)
Query: 289 VATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHT-GKSADYVNLSLKSGAVW 347
V G Y + D I+L F+T+Q +G++LH G + D++ L L+ ++
Sbjct: 183 VVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREGPNGDHITLQLRRARLF 242
Query: 348 LVINLGSGAFEALVEPVN----GKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTIS 403
L+IN G + VN +D WH V + R +Q + + H+
Sbjct: 243 LLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQRLGKQ---VNFTVDEHRHHF---- 295
Query: 404 VDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVS---NNFMGCLKDVVYKNND 460
+ + ++ ++ D GG P PG VS NF GCL+++ Y D
Sbjct: 296 ---------HARGEFNLMNLDYEISFGGIP----APGKSVSFPHRNFHGCLENLYYNGVD 342
Query: 461 FKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLD 520
+ LAK+ P++ G++SF C ++ PVTF S +++ALP +S + S +
Sbjct: 343 ----IIDLAKQQKPQIIAMGNVSFSCSQPQSM-PVTFLSSRSYLALPDFSGEEEVSATFQ 397
Query: 521 FRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASS 580
FRT GLLLFS+ + GG + L DG L L +
Sbjct: 398 FRTWNKAGLLLFSELQLISGG------------ILLFLSDGKLKSNLYQPGKLPSDITAG 445
Query: 581 RKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPE---GGRV 637
++NDG+W V S++V+ + E + Y GG P+ G +
Sbjct: 446 VELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGSKC 505
Query: 638 DLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETL---KQC 694
PL G+ GC+R + I G+ DL ++ QG++G ++ +C
Sbjct: 506 KSPL----------GGFQGCMRLISISGKVVDL--ISVQQGSLGNFSDLQIDSCGISDRC 553
Query: 695 ASAPCRNGGVCREGWNRFICDCIGTGFLGRVC 726
C +GG C + W+ F C+C TG+ G C
Sbjct: 554 LPNYCEHGGECSQSWSTFHCNCTNTGYRGATC 585
Score = 127 bits (320), Expect = 7e-29
Identities = 112/433 (25%), Positives = 175/433 (40%), Gaps = 46/433 (10%)
Query: 726 CEREATVLSYDGSMYMKIMLPNAMHTEAEDV-SLRFMSQRAYGLMMATTSRESADTLRLE 784
C + V+ DG + + +D+ SL+F + ++ G+++ + D + L+
Sbjct: 177 CAYRSEVVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREG-PNGDHITLQ 235
Query: 785 LDGGQMKLTVNLDCLRVGCAPSKGPET-----LFAGHKLNDNEWHTVRVVRRGKSLQLSV 839
L ++ L +N +K P T L G L+D WH+V + R GK + +V
Sbjct: 236 LRRARLFLLIN-------SGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTV 288
Query: 840 DNVTVEGQMAGAH--MRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCK 897
D G M L++ GI + +S NF G L L +NG +D K
Sbjct: 289 DEHRHHFHARGEFNLMNLDYEISFGGIPAPGKSVSFPHRNFHGCLENLYYNGVDIIDLAK 348
Query: 898 DGDITYCEL-NARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLL 956
+ N F + PVTF S SYLAL + FQF+T GLLL
Sbjct: 349 QQKPQIIAMGNVSFSCSQPQSMPVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLL 408
Query: 957 FNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKP------------VNDNQWHNV 1004
F+ ++L+ G I G +K N +P +ND QWH+V
Sbjct: 409 FSE--------LQLISGGILLFLSDGK----LKSNLYQPGKLPSDITAGVELNDGQWHSV 456
Query: 1005 VVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQG 1064
+S ++ G + G Y GG F + K + GFQG
Sbjct: 457 SLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGS--KCKSPLGGFQG 514
Query: 1065 CLASVDLNGRLPDLIA---DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCD 1121
C+ + ++G++ DLI+ +L ++ G S C C + G C Q W F C+
Sbjct: 515 CMRLISISGKVVDLISVQQGSLGNFSDLQIDSCGISDRCLPNYCEHGGECSQSWSTFHCN 574
Query: 1122 CTMTSYGGPVCND 1134
CT T Y G C++
Sbjct: 575 CTNTGYRGATCHN 587
Score = 116 bits (291), Expect = 2e-25
Identities = 99/343 (28%), Positives = 159/343 (46%), Gaps = 39/343 (11%)
Query: 921 TFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKG-YIHYVF 979
+F + +SYL T S + F FKTTA G+ L N G DFI IEL + + F
Sbjct: 796 SFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIA-DFIRIELRSPTVVTFSF 854
Query: 980 DLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS---RTVTQHSNGARNLDLK 1036
D+GNGP + S NDNQWH+V V R+ +L++D +T ++G L L
Sbjct: 855 DVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEA-SLQVDQLTPKTQPAPADGHVLLQLN 913
Query: 1037 GELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGP 1096
+L++GG + + GF GC+ S+ LNG DL + +V+ GC G
Sbjct: 914 SQLFVGGTATR-----------QRGFLGCIRSLQLNGMTLDL-EERAQVTPEVQPGCRGH 961
Query: 1097 STTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALI-----TYT 1151
++ + C N G C ++ GF CDCT ++Y GP C++ + Y FG G ++I Y
Sbjct: 962 CSSYGK-LCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAY-FGSGSSVIYNFQENYL 1019
Query: 1152 WPPND-------RPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI-DQGTVGVI 1203
N ++ R + FS + + +S +YL + I G++ +
Sbjct: 1020 LSKNSSSHAASFHGDMKLSREMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIR 1079
Query: 1204 FNVG----TDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1242
+ + D + D N ++DG+ H + R G +++D
Sbjct: 1080 YKLNKYQEPDVVNFDFKN--MADGQLHHIMINREEGVVFIEID 1120
Score = 86.3 bits (212), Expect = 2e-16
Identities = 73/267 (27%), Positives = 119/267 (44%), Gaps = 51/267 (19%)
Query: 479 QGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRA 538
QGD SF + +F++ +++ P + + + +S F+TT +G+ L + G
Sbjct: 786 QGDRSF-------WNSASFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGI-- 836
Query: 539 GGGAGSHSSAQRADYFAMELLDGHLYLL-LDMGSGGIKLRASS-RKVNDGEWCHVDFQRD 596
AD+ +EL + D+G+G ++ S ND +W HV +R+
Sbjct: 837 ------------ADFIRIELRSPTVVTFSFDVGNGPFEISVQSPTHFNDNQWHHVRVERN 884
Query: 597 GRKGSISVNS---RSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAG 653
++ S+ V+ ++ P A G +L L S+L++GG TA + G
Sbjct: 885 MKEASLQVDQLTPKTQPAPADGHV-LLQLNSQLFVGG----------------TATRQRG 927
Query: 654 YVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAP--CRNGGVCREGWNR 711
++GC+R L ++G + DL AQ V P C C+S CRNGG CRE
Sbjct: 928 FLGCIRSLQLNGMTLDLE--ERAQVTPEVQPGCRGH----CSSYGKLCRNGGKCRERPIG 981
Query: 712 FICDCIGTGFLGRVCEREATVLSYDGS 738
F CDC + + G C E + GS
Sbjct: 982 FFCDCTFSAYTGPFCSNEISAYFGSGS 1008
Score = 67.8 bits (164), Expect = 9e-11
Identities = 97/388 (25%), Positives = 157/388 (40%), Gaps = 77/388 (19%)
Query: 755 DVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFA 814
DVS F + + G+ + AD +R+EL + +T + D VG P + ++ +
Sbjct: 816 DVSFFFKTTASSGVFLENLG--IADFIRIELRSPTV-VTFSFD---VGNGPFE--ISVQS 867
Query: 815 GHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGA--HMRLEFHN--IETGIMTERRF 870
NDN+WH VRV R K L VD +T + Q A A H+ L+ ++ G T +R
Sbjct: 868 PTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLFVGGTATRQR- 926
Query: 871 ISVVPSNFIGHLSGLVFNG---------------QP--------YMDQCKDG-------- 899
F+G + L NG QP Y C++G
Sbjct: 927 ------GFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGHCSSYGKLCRNGGKCRERPI 980
Query: 900 ----DITYCELNARFGLRAIVA-----DPVTFKSRSSYLALATLQAYA-SMH-------- 941
D T+ F I A V + + +YL ++A S H
Sbjct: 981 GFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMKLSRE 1040
Query: 942 -LFFQFKTTAPDGLLLFNSGNGNDFIVIELVKG---YIHYVFDLGNGPSLMKGNSD-KPV 996
+ F F+TT LLLF S +++ + + K I Y + P ++ N D K +
Sbjct: 1041 MIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIRYKLNKYQEPDVV--NFDFKNM 1098
Query: 997 NDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLV 1056
D Q H+++++R+ G V D+R H + L +G + ++ + +
Sbjct: 1099 ADGQLHHIMINREEGVVFIEIDDNRRRQVHLSSGTEFSAVKSLVLGRILEHSDVDQDTAL 1158
Query: 1057 ASRDGFQGCLASVDLNGRLPDLIADALH 1084
A GF GCL++V L+ P + ALH
Sbjct: 1159 AGAQGFTGCLSAVQLSHVAP--LKAALH 1184
Score = 50.8 bits (120), Expect = 1e-05
Identities = 37/154 (24%), Positives = 67/154 (43%), Gaps = 26/154 (16%)
Query: 313 EITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAV-WLVINLGSGAFEALVEPVNGKFNDN 371
+++ F+T +G+ L AD++ + L+S V ++G+G FE V+ FNDN
Sbjct: 816 DVSFFFKTTASSGVFLENLGIADFIRIELRSPTVVTFSFDVGNGPFEISVQSPT-HFNDN 874
Query: 372 AWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQED-YTMLGSDDFFYIG 430
WH VRV RN+++ ++ VD + T D + +L + ++G
Sbjct: 875 QWHHVRVERNMKE---------------ASLQVDQLTPKTQPAPADGHVLLQLNSQLFVG 919
Query: 431 GSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLE 464
G+ F+GC++ + LE
Sbjct: 920 GTATR--------QRGFLGCIRSLQLNGMTLDLE 945
Score = 48.1 bits (113), Expect = 7e-05
Identities = 54/232 (23%), Positives = 91/232 (39%), Gaps = 25/232 (10%)
Query: 54 SFSLRTNATRALLLY----LDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVAD 109
+F RT LLL+ L GG + L L DG+L+ P+ + + D
Sbjct: 395 TFQFRTWNKAGLLLFSELQLISGG----ILLFLSDGKLKSNLYQPGKLPSDITAGVELND 450
Query: 110 DRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTV 169
+WH V L+ ++AVDG+ +A ++ + GG PD + S +
Sbjct: 451 GQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGC-PDKSFGSKCKSPL 509
Query: 170 KYEPPFRGLLANLKLGERPPALLG-SQGLRGATAD---------PLCAPARNPCANGGLC 219
F+G + + + + L+ QG G +D C P N C +GG C
Sbjct: 510 ---GGFQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDSCGISDRCLP--NYCEHGGEC 564
Query: 220 TVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAG 271
+ + C+C++TG+ G C + A+ + G G+G
Sbjct: 565 S-QSWSTFHCNCTNTGYRGATCHNSIYEQSCEAYKHRGNTSGFYYIDSDGSG 615
Score = 48.1 bits (113), Expect = 7e-05
Identities = 54/208 (25%), Positives = 86/208 (41%), Gaps = 35/208 (16%)
Query: 50 SGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAE---PATLQLDTP 106
S ++SF +T A+ + +L++ G DF+ + L + + F+ ++Q T
Sbjct: 814 SADVSFFFKTTASSGV--FLENLGIADFIRIELRSPTV-VTFSFDVGNGPFEISVQSPTH 870
Query: 107 VADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRRE--MQVASDLFVGGIPPDVRLSAL 164
D++WH V + R+ + +L VD + +Q+ S LFVGG
Sbjct: 871 FNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLFVGG---------- 920
Query: 165 TLSTVKYEPPFRGLLANLKLG-------ERPPALLGSQ-GLRGATADPLCAPARNPCANG 216
T + F G + +L+L ER Q G RG C+ C NG
Sbjct: 921 ---TATRQRGFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGH-----CSSYGKLCRNG 972
Query: 217 GLCTVLAPGEVGCDCSHTGFGGKFCSEE 244
G C G CDC+ + + G FCS E
Sbjct: 973 GKCRERPIGFF-CDCTFSAYTGPFCSNE 999
Score = 36.6 bits (83), Expect = 0.22
Identities = 36/156 (23%), Positives = 66/156 (42%), Gaps = 7/156 (4%)
Query: 7 WRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALL 66
W P + + + A R++ ++ G R+ + + + +S +T + +L
Sbjct: 162 WNPKGRIGMRIEVFGCAYRSEVVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGIL 221
Query: 67 LYLDDGGDCDFLELLLVDGRLRLRFTLSCAE-PAT-----LQLDTPVADDRWHMVLLTRD 120
L+ + G + D + L L RL L A+ P+T L L + + D WH VL+ R
Sbjct: 222 LHRE-GPNGDHITLQLRRARLFLLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQRL 280
Query: 121 ARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIP 156
++ VD R + M + ++ GGIP
Sbjct: 281 GKQVNFTVDEHRHHFHARGEFNLMNLDYEISFGGIP 316
>gi|239743754 PREDICTED: hypothetical protein LOC389722 isoform 1
[Homo sapiens]
Length = 1288
Score = 135 bits (339), Expect = 4e-31
Identities = 120/453 (26%), Positives = 192/453 (42%), Gaps = 67/453 (14%)
Query: 289 VATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHT-GKSADYVNLSLKSGAVW 347
V F G Y L P++ D I+L F+ +Q NG++LH G+ +++ L L G +
Sbjct: 183 VVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHGNHITLELIKGKLV 242
Query: 348 LVINLGSGAFEALVEPVN----GKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTIS 403
+N G+ + + PV +D WH V ++ L V +
Sbjct: 243 FFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSV---------------LIELLDTQVNFT 287
Query: 404 VDGILTTTGYTQEDYTMLGSDDFFYIGG--SPNTADLPGSPVSNNFMGCLKDVVYKNNDF 461
VD T + D + L + GG SP + + +F GCL+++ Y D
Sbjct: 288 VDKH-THHFQAKGDSSNLDLNFEISFGGILSPGRSR---AFTRKSFHGCLENLYYNGVD- 342
Query: 462 KLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDF 521
++ LAK+ P++ + G++SF C + PVTF S +++ALP S + S++ F
Sbjct: 343 ---VTELAKKHKPQILMMGNVSFSCPQPQTV-PVTFLSSRSYLALPGNSGEDKVSVTFQF 398
Query: 522 RTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSR 581
RT G LLF + +R G F + L DG L L L + +
Sbjct: 399 RTWNRAGHLLFGELQRGSGS------------FVLFLKDGKLKLSLFQAGQSPRNVTAGA 446
Query: 582 KVNDGEWCHVDFQRDGRKGSISVNSRST--PFLATGDSEILDLESELYLGGL---PEGGR 636
+NDG+W V F ++ V+ + P +A ++D Y GG G
Sbjct: 447 GLNDGQWHSVSFSAKWSHMNVVVDDDTAVQPLVAV----LIDSGDTYYFGGCLGNSSGSG 502
Query: 637 VDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGV---APFCSRETLKQ 693
PL G+ GC+R + I ++ D + QGA+G S +
Sbjct: 503 CKSPL----------GGFQGCLRLITIGDKAVD--PILVQQGALGSFRDLQIDSCGITDR 550
Query: 694 CASAPCRNGGVCREGWNRFICDCIGTGFLGRVC 726
C + C +GG C + W+ F CDC+GTG+ G C
Sbjct: 551 CLPSYCEHGGECSQSWDTFSCDCLGTGYTGETC 583
Score = 115 bits (289), Expect = 3e-25
Identities = 113/418 (27%), Positives = 176/418 (42%), Gaps = 20/418 (4%)
Query: 726 CEREATVLSYDGSMYMKIMLPNAMHTEAEDV-SLRFMSQRAYGLMMATTSRESADTLRLE 784
C ++ V+ +DG + L DV SL+F + ++ G+++ + + + LE
Sbjct: 177 CAYKSEVVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHG-NHITLE 235
Query: 785 LDGGQMKLTVNLDCLRVGCAPSK-GPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVT 843
L G++ +N ++ PS P TL G L+D WH+V + + +VD T
Sbjct: 236 LIKGKLVFFLNSGNAKL---PSTIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHT 292
Query: 844 VEGQMAG--AHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDI 901
Q G +++ L F GI++ R + +F G L L +NG + K
Sbjct: 293 HHFQAKGDSSNLDLNFEISFGGILSPGRSRAFTRKSFHGCLENLYYNGVDVTELAKKHKP 352
Query: 902 TYCEL-NARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS- 959
+ N F PVTF S SYLAL + + FQF+T G LLF
Sbjct: 353 QILMMGNVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFGEL 412
Query: 960 GNGNDFIVIELVKGYIHY-VFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKI 1018
G+ V+ L G + +F G P + + +ND QWH+V S +++ + +
Sbjct: 413 QRGSGSFVLFLKDGKLKLSLFQAGQSPRNVTAGAG--LNDGQWHSVSFSAKWSHMNVV-V 469
Query: 1019 DSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDL 1078
D T Q +D Y GG N + K + GFQGCL + + + D
Sbjct: 470 DDDTAVQPLVAVL-IDSGDTYYFGGCLGNSSGSGCK--SPLGGFQGCLRLITIGDKAVDP 526
Query: 1079 IA---DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCN 1133
I AL ++ G + C C + G C Q WD F+CDC T Y G C+
Sbjct: 527 ILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCH 584
Score = 111 bits (278), Expect = 5e-24
Identities = 99/345 (28%), Positives = 159/345 (46%), Gaps = 43/345 (12%)
Query: 921 TFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIEL-VKGYIHYVF 979
+F + +SYL + + F FKTT G+ + N G DFI IEL + + F
Sbjct: 796 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI-TDFIRIELRAPTEVTFSF 854
Query: 980 DLGNGPSLMKGNSDKPVNDNQWHNVVVSRD--PGNVHTLKIDSRTVTQHSNGARNLDLKG 1037
D+GNGP + S P NDNQWH+V R+ ++ ++ + ++G L L
Sbjct: 855 DVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNS 914
Query: 1038 ELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPS 1097
+L+IGG + + GF GC+ S+ LNG DL A G VE GC G
Sbjct: 915 QLFIGGTA-----------TRQRGFLGCIRSLQLNGVALDLEERATVTPG-VEPGCAGHC 962
Query: 1098 TTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALI-----TYTW 1152
+T C N G C ++ G TCDC ++Y GP C++ + Y F G ++ YT
Sbjct: 963 ST-YGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEISAY-FATGSSMTYHFQEHYTL 1020
Query: 1153 PPN----------DRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI-DQGTVG 1201
N D TR + + + F T + ++L+ V +S +YL + + + G++
Sbjct: 1021 SENSSSLVSSLYRDVTLTR-EMITLSFRTTRSPSLLLYV--SSFYEEYLSVILANNGSLQ 1077
Query: 1202 VIFNV----GTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1242
+ + + D T D N ++DG+ H V+ R ++V+
Sbjct: 1078 IRYKLDRHQNPDAFTFDFKN--MADGQLHQVKINREEAVVMVEVN 1120
Score = 73.9 bits (180), Expect = 1e-12
Identities = 65/258 (25%), Positives = 110/258 (42%), Gaps = 44/258 (17%)
Query: 488 DVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSS 547
D + + +F + +++ P + + T + F+TT +G+ + + G
Sbjct: 788 DKSFWNSASFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI----------- 836
Query: 548 AQRADYFAMEL-LDGHLYLLLDMGSGGIKLRASS-RKVNDGEWCHVDFQRDGRKGSISVN 605
D+ +EL + D+G+G ++ S ND +W HV +R+ + S+ V+
Sbjct: 837 ---TDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVD 893
Query: 606 S---RSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLF 662
+ P A G L L S+L++GG TA + G++GC+R L
Sbjct: 894 QLPQKMQPAPADGHVR-LQLNSQLFIGG----------------TATRQRGFLGCIRSLQ 936
Query: 663 IDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAP--CRNGGVCREGWNRFICDCIGTG 720
++G + DL A GV P C+ C++ CRNGG CRE CDC +
Sbjct: 937 LNGVALDLEERATV--TPGVEPGCAGH----CSTYGHLCRNGGRCREKRRGVTCDCAFSA 990
Query: 721 FLGRVCEREATVLSYDGS 738
+ G C E + GS
Sbjct: 991 YDGPFCSNEISAYFATGS 1008
Score = 50.4 bits (119), Expect = 1e-05
Identities = 44/155 (28%), Positives = 64/155 (41%), Gaps = 29/155 (18%)
Query: 100 TLQLDTPVADDRWHMVLLTRDARRTALAVD--GEARAAEVRSKRREMQVASDLFVGGIPP 157
T+Q TP D++WH V R+ + +L VD + +Q+ S LF+GG
Sbjct: 864 TVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGG--- 920
Query: 158 DVRLSALTLSTVKYEPPFRGLLANLKLG-------ERPPALLGSQ-GLRGATADPLCAPA 209
T + F G + +L+L ER G + G G C+
Sbjct: 921 ----------TATRQRGFLGCIRSLQLNGVALDLEERATVTPGVEPGCAGH-----CSTY 965
Query: 210 RNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEE 244
+ C NGG C G V CDC+ + + G FCS E
Sbjct: 966 GHLCRNGGRCREKRRG-VTCDCAFSAYDGPFCSNE 999
Score = 43.1 bits (100), Expect = 0.002
Identities = 86/387 (22%), Positives = 139/387 (35%), Gaps = 74/387 (19%)
Query: 748 AMHTE-AEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPS 806
A H E DV F + + G+ M D +R+EL ++T + D VG P
Sbjct: 808 AFHGELTADVCFFFKTTVSSGVFMENLG--ITDFIRIELRA-PTEVTFSFD---VGNGPC 861
Query: 807 KGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGA--HMRLEFHN--IET 862
+ T+ + NDN+WH VR R K L VD + + Q A A H+RL+ ++
Sbjct: 862 E--VTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIG 919
Query: 863 GIMTERRFISVVPSNFIGHLSGLVFNG-----------------------QPYMDQCKDG 899
G T +R F+G + L NG Y C++G
Sbjct: 920 GTATRQR-------GFLGCIRSLQLNGVALDLEERATVTPGVEPGCAGHCSTYGHLCRNG 972
Query: 900 -------------------DITYC--ELNARFGLRAIVA----DPVTFKSRSSYLALATL 934
D +C E++A F + + + T SS L +
Sbjct: 973 GRCREKRRGVTCDCAFSAYDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSSLY 1032
Query: 935 Q--AYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKG---YIHYVFDLGNGPSLMK 989
+ + F+TT LLL+ S +++ + L I Y D P
Sbjct: 1033 RDVTLTREMITLSFRTTRSPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFT 1092
Query: 990 GNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMF 1049
+ K + D Q H V ++R+ V S + + L +G + +
Sbjct: 1093 FDF-KNMADGQLHQVKINREEAVVMVEVNQSAKKQVILSSGTEFNAVKSLILGKVLEAAG 1151
Query: 1050 SNLPKLVASRDGFQGCLASVDLNGRLP 1076
++ A+ GF GCL++V P
Sbjct: 1152 ADPDTRRAATSGFTGCLSAVRFGRAAP 1178
Score = 40.0 bits (92), Expect = 0.019
Identities = 21/74 (28%), Positives = 38/74 (51%), Gaps = 2/74 (2%)
Query: 311 TDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGA-VWLVINLGSGAFEALVEPVNGKFN 369
T ++ F+T +G+ + D++ + L++ V ++G+G E V+ FN
Sbjct: 814 TADVCFFFKTTVSSGVFMENLGITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPT-PFN 872
Query: 370 DNAWHDVRVTRNLR 383
DN WH VR RN++
Sbjct: 873 DNQWHHVRAERNVK 886
Score = 38.9 bits (89), Expect = 0.043
Identities = 45/175 (25%), Positives = 74/175 (42%), Gaps = 21/175 (12%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVD-GRLRLRFTLSCAE-PATLQLDTP-VAD 109
++ S RT + +LLLY+ + ++L ++L + G L++R+ L + P D +AD
Sbjct: 1042 ITLSFRTTRSPSLLLYVSSFYE-EYLSVILANNGSLQIRYKLDRHQNPDAFTFDFKNMAD 1100
Query: 110 DRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVG------GIPPDVRLSA 163
+ H V + R+ + V+ A+ + S E L +G G PD R +A
Sbjct: 1101 GQLHQVKINREEAVVMVEVNQSAKKQVILSSGTEFNAVKSLILGKVLEAAGADPDTRRAA 1160
Query: 164 LTLSTVKYEPPFRGLLANLKLGERPP--ALLGSQGLRGATADPLCAPARNPCANG 216
+ F G L+ ++ G P A L G T AP CA G
Sbjct: 1161 TS--------GFTGCLSAVRFGRAAPLKAALRPSGPSRVTVRGHVAPMAR-CAAG 1206
Score = 37.4 bits (85), Expect = 0.13
Identities = 51/237 (21%), Positives = 86/237 (36%), Gaps = 23/237 (9%)
Query: 49 SSGE----LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLD 104
+SGE ++F RT LL+ + L L DG+L+L + P +
Sbjct: 386 NSGEDKVSVTFQFRTWNRAGHLLFGELQRGSGSFVLFLKDGKLKLSLFQAGQSPRNVTAG 445
Query: 105 TPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSAL 164
+ D +WH V + + VD + + + + + GG + S
Sbjct: 446 AGLNDGQWHSVSFSAKWSHMNVVVDDDTAVQPLVAVL--IDSGDTYYFGGCLGNSSGSGC 503
Query: 165 TLSTVKYEPPFRGLLANLKLGERP-PALLGSQGLRGATAD---------PLCAPARNPCA 214
F+G L + +G++ +L QG G+ D C P+ C
Sbjct: 504 KSPL----GGFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDRCLPSY--CE 557
Query: 215 NGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAG 271
+GG C+ + CDC TG+ G+ C + AH + G G+G
Sbjct: 558 HGGECSQ-SWDTFSCDCLGTGYTGETCHSSLYEQSCEAHKHRGNPSGLYYIDADGSG 613
Score = 32.3 bits (72), Expect = 4.1
Identities = 27/105 (25%), Positives = 41/105 (39%), Gaps = 9/105 (8%)
Query: 78 LELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEV 137
L L G +L T++ P TL L + + D WH VL+ + VD +
Sbjct: 241 LVFFLNSGNAKLPSTIA---PVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHTHHFQA 297
Query: 138 RSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANL 182
+ + + ++ GGI R A T + F G L NL
Sbjct: 298 KGDSSNLDLNFEISFGGILSPGRSRAFTRKS------FHGCLENL 336
Score = 32.0 bits (71), Expect = 5.3
Identities = 25/83 (30%), Positives = 43/83 (51%), Gaps = 5/83 (6%)
Query: 1186 GLGDYLQLHIDQGT-VGVIFNVGTD--DITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1242
G+ D++++ + T V F+VG ++T+ P +D ++H VR R+ A+LQVD
Sbjct: 835 GITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPF-NDNQWHHVRAERNVKGASLQVD 893
Query: 1243 SWPVNERYPAGNFDNERLAIARQ 1265
P + PA + RL + Q
Sbjct: 894 QLP-QKMQPAPADGHVRLQLNSQ 915
>gi|4505463 contactin associated protein 1 precursor [Homo sapiens]
Length = 1384
Score = 130 bits (328), Expect = 8e-30
Identities = 118/449 (26%), Positives = 190/449 (42%), Gaps = 63/449 (14%)
Query: 292 FKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHT-GKSADYVNLSLKSGAVWLVI 350
F G++ Y +S D +F+T +++GL+LH G DYV L L+ + L +
Sbjct: 177 FDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQGDYVTLELEGAHLLLHM 236
Query: 351 NLGSGAFEA----LVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDG 406
+LGS + G ND WH VRV R R D
Sbjct: 237 SLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGR---------------------DV 275
Query: 407 ILTTTGYTQE-----DYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDF 461
T GY Q D+ L D +IGG A +NF GC+++V++
Sbjct: 276 NFTLDGYVQRFILNGDFERLNLDTEMFIGGLVGAAR-KNLAYRHNFRGCIENVIFN---- 330
Query: 462 KLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDF 521
++ ++ LA ++ +G ++FRC D P+ F P FV +P + + ++S F
Sbjct: 331 RVNIADLAVRRHSRITFEGKVAFRCLDPVP-HPINFGGPHNFVQVPGFPRRGRLAVSFRF 389
Query: 522 RTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLR-ASS 580
RT + GLLLFS R G G G + + L +G + + + SG KL+ A+
Sbjct: 390 RTWDLTGLLLFS---RLGDGLG---------HVELTLSEGQVNVSIAQ-SGRKKLQFAAG 436
Query: 581 RKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLP 640
++NDG W V+F IS++ + ++ + + GG P+
Sbjct: 437 YRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPK------- 489
Query: 641 LPPEVWTA-ALRAGYVGCVRDLFIDGRSRDLRGLAEAQ--GAVGVAPFCSRETLKQCASA 697
P W + + + GC+ L +DG+ +L L E + G F + +C+
Sbjct: 490 -PASRWDCHSNQTAFHGCMELLKVDGQLVNLT-LVEGRRLGFYAEVLFDTCGITDRCSPN 547
Query: 698 PCRNGGVCREGWNRFICDCIGTGFLGRVC 726
C + G C + W+ FIC C TG+ G C
Sbjct: 548 MCEHDGRCYQSWDDFICYCELTGYKGETC 576
Score = 110 bits (276), Expect = 9e-24
Identities = 110/429 (25%), Positives = 184/429 (42%), Gaps = 36/429 (8%)
Query: 726 CEREATVLSYDGSMYMKIMLPNAMHTEAEDV-SLRFMSQRAYGLMMATTSRESADTLRLE 784
C +A +L +DG + P + DV + F ++ GL++ + D + LE
Sbjct: 168 CPYKADILYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQG-DYVTLE 226
Query: 785 LDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTV 844
L+G + L ++L + P G T+ AG LND WH VRV R G+ + ++D
Sbjct: 227 LEGAHLLLHMSLGSSPI--QPRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGYVQ 284
Query: 845 EGQMAGAHMRLEFHNIET-----GIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQC--K 897
+ G RL N++T G++ R NF G + ++FN D +
Sbjct: 285 RFILNGDFERL---NLDTEMFIGGLVGAARKNLAYRHNFRGCIENVIFNRVNIADLAVRR 341
Query: 898 DGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLF 957
IT+ E F V P+ F +++ + + + F+F+T GLLLF
Sbjct: 342 HSRITF-EGKVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLF 400
Query: 958 NS-GNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNV-VVSRDPGNVHT 1015
+ G+G + + L +G ++ V +G ++ + +ND WH V V+++ N
Sbjct: 401 SRLGDGLGHVELTLSEGQVN-VSIAQSGRKKLQFAAGYRLNDGFWHEVNFVAQE--NHAV 457
Query: 1016 LKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRD------GFQGCLASV 1069
+ ID GA + + L I + F PK + D F GC+ +
Sbjct: 458 ISIDD------VEGAE-VRVSYPLLIRTGTSYFFGGCPKPASRWDCHSNQTAFHGCMELL 510
Query: 1070 DLNGRLPDLIADALHRIG---QVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTS 1126
++G+L +L R+G +V G + C+ C + G C Q WD F C C +T
Sbjct: 511 KVDGQLVNLTLVEGRRLGFYAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTG 570
Query: 1127 YGGPVCNDP 1135
Y G C+ P
Sbjct: 571 YKGETCHTP 579
Score = 92.0 bits (227), Expect = 4e-18
Identities = 120/509 (23%), Positives = 200/509 (39%), Gaps = 130/509 (25%)
Query: 929 LALATLQAYASMHLFFQFKTTAPDGLLLFNSGNG-----NDFIVIEL-VKGYIHYVFDLG 982
L ++A S+ + F F+T+AP G+ L N G ++ +EL + + FD+G
Sbjct: 796 LRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPYVRVELNTSRDVVFAFDVG 855
Query: 983 NGPSLMKGNSDK-PVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARN---LDLKGE 1038
NG + +SD ND++WH V + L++D R + ++
Sbjct: 856 NGDENLTVHSDDFEFNDDEWHLVRAEINVKQAR-LRVDHRPWVLRPMPLQTYIWMEYDQP 914
Query: 1039 LYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPST 1098
LY+G R F GCL ++ LNG +L A +G S
Sbjct: 915 LYVGSAE-----------LKRRPFVGCLRAMRLNGVTLNLEGRA--------NASEGTSP 955
Query: 1099 TCTEES------CANQGVCLQQWDGFTCDCTMTSYGGPVCN-------DPGTTYIFGKGG 1145
CT C + G C++++ +TCDC +T++ GP CN +PGT +
Sbjct: 956 NCTGHCAHPRLPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFEPGTWMRYNLQS 1015
Query: 1146 ALIT-------------------------------------YTWPPNDRPSTRM------ 1162
AL + Y P RP +
Sbjct: 1016 ALRSAAREFSHMLSRPVPGYEPGYIPGYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYRGP 1075
Query: 1163 ------DRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI-DQGTVGVIFNVGTDDITIDE 1215
+ ++ FST AVL+ V +S + DY+ + I D GT+ + + +GT
Sbjct: 1076 VYNVTGEEVSFSFSTSSAPAVLLYV--SSFVRDYMAVLIKDDGTLQLRYQLGTSPYVYQL 1133
Query: 1216 PNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVV 1275
V+DG+ H + TR N +QVD +P+ E+ + D++ + + Y LGRV+
Sbjct: 1134 TTRPVTDGQPHSINITRVYRNLFIQVDYFPLTEQKFSLLVDSQ---LDSPKALY-LGRVM 1189
Query: 1276 DEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVL--------ALAAES 1327
+ ++D ++ +N+ F G +SG+ +N + L + AE
Sbjct: 1190 ETGVIDP--EIQRYNTPG------------FSGCLSGVRFNNVAPLKTHFRTPRPMTAEL 1235
Query: 1328 DPNVRTEGHL---------RLVGEGPSVL 1347
+R +G L RLV E P L
Sbjct: 1236 AEALRVQGELSESNCGAMPRLVSEVPPEL 1264
Score = 61.2 bits (147), Expect = 8e-09
Identities = 69/262 (26%), Positives = 121/262 (46%), Gaps = 36/262 (13%)
Query: 502 AFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDG 561
A + P A + +S FRT+ P+G+ L + G G + +R Y +EL
Sbjct: 794 AALRFPPIRANHSLDVSFYFRTSAPSGVFLENMG-------GPYCQWRRP-YVRVELNTS 845
Query: 562 H-LYLLLDMGSGGIKLRASSR--KVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSE 618
+ D+G+G L S + ND EW V + + ++ + V+ R P++
Sbjct: 846 RDVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHR--PWVLRP--- 900
Query: 619 ILDLESELYLGGLPEGGRVDLPLPPEVWTAAL-RAGYVGCVRDLFIDGRSRDLRGLAEAQ 677
+ L++ +++ D PL V +A L R +VGC+R + ++G + +L G A A
Sbjct: 901 -MPLQTYIWM-------EYDQPL--YVGSAELKRRPFVGCLRAMRLNGVTLNLEGRANA- 949
Query: 678 GAVGVAPFCSRETLKQCASA--PCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSY 735
+ G +P C+ CA PC +GG C E ++ + CDC T F G C + +
Sbjct: 950 -SEGTSPNCTGH----CAHPRLPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGF-F 1003
Query: 736 DGSMYMKIMLPNAMHTEAEDVS 757
+ +M+ L +A+ + A + S
Sbjct: 1004 EPGTWMRYNLQSALRSAAREFS 1025
Score = 48.1 bits (113), Expect = 7e-05
Identities = 44/182 (24%), Positives = 72/182 (39%), Gaps = 13/182 (7%)
Query: 7 WRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALL 66
W P L L L +AD L F G R+ R + +FS +T LL
Sbjct: 153 WNPRGKIGLRLGLYGCPYKADILYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLL 212
Query: 67 LYLDDGGDCDFLELLLVDGRLRLRFTLSCA--EP----ATLQLDTPVADDRWHMVLLTRD 120
L+ + G D++ L L L L +L + +P T+ + D WH V + R
Sbjct: 213 LHAE-GAQGDYVTLELEGAHLLLHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRF 271
Query: 121 ARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLA 180
R +DG + + + + +++F+GG+ R + Y FRG +
Sbjct: 272 GRDVNFTLDGYVQRFILNGDFERLNLDTEMFIGGLVGAAR------KNLAYRHNFRGCIE 325
Query: 181 NL 182
N+
Sbjct: 326 NV 327
Score = 42.4 bits (98), Expect = 0.004
Identities = 56/231 (24%), Positives = 88/231 (38%), Gaps = 21/231 (9%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRW 112
+SF RT LLL+ G +EL L +G++ + S + + D W
Sbjct: 385 VSFRFRTWDLTGLLLFSRLGDGLGHVELTLSEGQVNVSIAQSGRKKLQFAAGYRLNDGFW 444
Query: 113 HMVLLTRDARRTALAVDGEARAAEVR-SKRREMQVASDLFVGGIP-PDVRLSALTLSTVK 170
H V +++D + AEVR S ++ + F GG P P R + T
Sbjct: 445 HEVNFVAQENHAVISID-DVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWDCHSNQTA- 502
Query: 171 YEPPFRGLLANLKLGERPPALLGSQGLR-GATADPL---------CAPARNPCANGGLCT 220
F G + LK+ + L +G R G A+ L C+P N C + G C
Sbjct: 503 ----FHGCMELLKVDGQLVNLTLVEGRRLGFYAEVLFDTCGITDRCSP--NMCEHDGRC- 555
Query: 221 VLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAG 271
+ + C C TG+ G+ C + A+ G+ G+G
Sbjct: 556 YQSWDDFICYCELTGYKGETCHTPLYKESCEAYRLSGKTSGNFTIDPDGSG 606
Score = 40.4 bits (93), Expect = 0.015
Identities = 92/413 (22%), Positives = 147/413 (35%), Gaps = 76/413 (18%)
Query: 109 DDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASD--LFVGGIPPDVRLSALTL 166
DD WH+V + ++ L VD + + + D L+VG R
Sbjct: 872 DDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQTYIWMEYDQPLYVGSAELKRR------ 925
Query: 167 STVKYEPPFRGLLANLKLGERPPALLGSQGLRGATADPL---CAPARNPCANGGLCTVLA 223
PF G L ++L L G T+ CA R PC +GG C V
Sbjct: 926 -------PFVGCLRAMRLNGVTLNLEGRANASEGTSPNCTGHCAHPRLPCFHGGRC-VER 977
Query: 224 PGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTK 283
CDC T F G +C+ + P + + S L S A R + + +P
Sbjct: 978 YSYYTCDCDLTAFDGPYCNHDIGGFFEPG-TWMRYNLQSALRS---AAREFSHMLSRPVP 1033
Query: 284 GKEE----------FVATFKGNEFFCYDLS---------HNPIQSST-DEITLAFRTLQR 323
G E +V + G + D P+ + T +E++ +F T
Sbjct: 1034 GYEPGYIPGYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYRGPVYNVTGEEVSFSFSTSSA 1093
Query: 324 NGLMLHTGKSA-DYVNLSLK-SGAVWLVINLGSG--AFEALVEPVNGKFNDNAWHDVRVT 379
++L+ DY+ + +K G + L LG+ ++ PV D H + +T
Sbjct: 1094 PAVLLYVSSFVRDYMAVLIKDDGTLQLRYQLGTSPYVYQLTTRPV----TDGQPHSINIT 1149
Query: 380 RNLRQHAGIGHAMVNKLHYLVTISVDGI-LTTTGYTQEDYTMLGSDDFFYIGGSPNTADL 438
R R + I VD LT ++ + L S Y+G T +
Sbjct: 1150 RVYRN---------------LFIQVDYFPLTEQKFSLLVDSQLDSPKALYLGRVMETGVI 1194
Query: 439 PGSPVSNN---FMGCLKDVVYKN-----NDFKLELSRLAKEGDPKMKLQGDLS 483
N F GCL V + N F+ A+ + +++QG+LS
Sbjct: 1195 DPEIQRYNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAE-ALRVQGELS 1246
Score = 40.4 bits (93), Expect = 0.015
Identities = 29/79 (36%), Positives = 41/79 (51%), Gaps = 2/79 (2%)
Query: 52 ELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDT-PVADD 110
E+SFS T++ A+LLY+ L+ DG L+LR+ L P QL T PV D
Sbjct: 1083 EVSFSFSTSSAPAVLLYVSSFVRDYMAVLIKDDGTLQLRYQLG-TSPYVYQLTTRPVTDG 1141
Query: 111 RWHMVLLTRDARRTALAVD 129
+ H + +TR R + VD
Sbjct: 1142 QPHSINITRVYRNLFIQVD 1160
>gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapiens]
Length = 1331
Score = 130 bits (328), Expect = 8e-30
Identities = 99/351 (28%), Positives = 163/351 (46%), Gaps = 46/351 (13%)
Query: 921 TFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGY-IHYVF 979
+F + SSYL +T Q S + F FKT P G+ L N G DFI +EL + + F
Sbjct: 802 SFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGK-EDFIKLELKSATEVSFSF 860
Query: 980 DLGNGPSLMKGNSDKPVNDNQWHNVVVSRD--PGNVHTLKIDSRTVTQHSNGARNLDLKG 1037
D+GNGP + S P+ND+QWH V R+ ++ ++ + + G L+L
Sbjct: 861 DVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTRLELYS 920
Query: 1038 ELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPS 1097
+L++GG + GF GC+ S+ +NG DL A G + GC G
Sbjct: 921 QLFVGG------------AGGQQGFLGCIRSLRMNGVTLDLEERAKVTSGFIS-GCSGHC 967
Query: 1098 TTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCN-DPGTTYIFGKGGALITYTW---- 1152
T+ +C N G CL+++ G++CDC+ T+Y G CN D G F + G + Y +
Sbjct: 968 TSYGT-NCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGA---FFEEGMWLRYNFQAPA 1023
Query: 1153 ---------------PPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI-D 1196
N P + + FST + +L+ + S + D+L + +
Sbjct: 1024 TNARDSSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCILLYISSFT--TDFLAVLVKP 1081
Query: 1197 QGTVGVIFNVG--TDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWP 1245
G++ + +N+G + ID + +++G+ H V TR L++D +P
Sbjct: 1082 TGSLQIRYNLGGTREPYNIDVDHRNMANGQPHSVNITRHEKTIFLKLDHYP 1132
Score = 114 bits (284), Expect = 1e-24
Identities = 107/424 (25%), Positives = 191/424 (45%), Gaps = 27/424 (6%)
Query: 726 CEREATVLSYDGSMYMKIMLPNA-MHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLE 784
C A V+++DG + + N M T + ++L F + + G+++ ++ D + LE
Sbjct: 181 CSYWADVINFDGHVVLPYRFRNKKMKTLKDVIALNFKTSESEGVILHGEGQQG-DYITLE 239
Query: 785 LDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTV 844
L ++ L++NL ++G P G ++ G L+D+ WH+V + R+G+S+ L++D
Sbjct: 240 LKKAKLVLSLNLGSNQLG--PIYGHTSVMTGSLLDDHHWHSVVIERQGRSINLTLDRSMQ 297
Query: 845 EGQMAGA--HMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDIT 902
+ G ++ L++ GI + S NF G + + +NG D + +
Sbjct: 298 HFRTNGEFDYLDLDYEITFGGIPFSGKPSSSSRKNFKGCMESINYNGVNITDLARRKKLE 357
Query: 903 YCEL-NARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLF---- 957
+ N F PV F + +SYL + + FQF+T P+GLL+F
Sbjct: 358 PSNVGNLSFSCVEPYTVPVFFNA-TSYLEVPGRLNQDLFSVSFQFRTWNPNGLLVFSHFA 416
Query: 958 -NSGNGNDFIVIELVKGYIHYVFDLGNGP-SLMKGNSDKPVNDNQWHNV-VVSRDPGNVH 1014
N GN + I+L + + ++ S + +S +ND QWH V ++++ +
Sbjct: 417 DNLGN----VEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHEVRFLAKENFAIL 472
Query: 1015 TLKIDSRTVTQHSNGARNLDLK-GELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNG 1073
T+ D + + ++ L +K GE Y G N +N V + FQGC+ + ++
Sbjct: 473 TIDGDEASAVRTNSP---LQVKTGEKYFFGGFLNQMNNSSHSVL-QPSFQGCMQLIQVDD 528
Query: 1074 RLPDLIADALHRIGQ---VERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGP 1130
+L +L A + G V C C + G C Q WD F C C T Y G
Sbjct: 529 QLVNLYEVAQRKPGSFANVSIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGA 588
Query: 1131 VCND 1134
C++
Sbjct: 589 TCHN 592
Score = 105 bits (261), Expect = 5e-22
Identities = 105/455 (23%), Positives = 185/455 (40%), Gaps = 68/455 (14%)
Query: 289 VATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH-TGKSADYVNLSLKSGAVW 347
V F G+ Y + +++ D I L F+T + G++LH G+ DY+ L LK +
Sbjct: 187 VINFDGHVVLPYRFRNKKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLV 246
Query: 348 LVINLGS---GAFEALVEPVNGKF-NDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTIS 403
L +NLGS G + G +D+ WH V + R R + ++
Sbjct: 247 LSLNLGSNQLGPIYGHTSVMTGSLLDDHHWHSVVIERQGRS---------------INLT 291
Query: 404 VDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKL 463
+D + T ++ L D GG P + P S NF GC++ + Y +
Sbjct: 292 LDRSMQHFR-TNGEFDYLDLDYEITFGGIPFSGK-PSSSSRKNFKGCMESINYNG----V 345
Query: 464 ELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRT 523
++ LA+ + G+LSF C + + PV F + +++ +P + S+S FRT
Sbjct: 346 NITDLARRKKLEPSNVGNLSFSCVEPYTV-PVFFNAT-SYLEVPGRLNQDLFSVSFQFRT 403
Query: 524 TEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKV 583
PNGLL+FS +FA L G++ + L G+ + + K+
Sbjct: 404 WNPNGLLVFS-------------------HFADNL--GNVEIDLTESKVGVHINITQTKM 442
Query: 584 -----------NDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLP 632
NDG+W V F ++++ + T + + + GG
Sbjct: 443 SQIDISSGSGLNDGQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGF- 501
Query: 633 EGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQ-GAVGVAPFCSRETL 691
L + L+ + GC++ + +D + +L +A+ + G+ +
Sbjct: 502 ------LNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSIDMCAII 555
Query: 692 KQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVC 726
+C C +GG C + W+ F C C TG+ G C
Sbjct: 556 DRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATC 590
Score = 75.5 bits (184), Expect = 4e-13
Identities = 87/392 (22%), Positives = 163/392 (41%), Gaps = 76/392 (19%)
Query: 476 MKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQG 535
++ QGD ++ + +F +P +++ + + + IS F+T P G+ L + G
Sbjct: 789 LRCQGDRNY-------WNAASFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMG 841
Query: 536 RRAGGGAGSHSSAQRADYFAMELLDG-HLYLLLDMGSGGIKLRASS-RKVNDGEWCHVDF 593
+ D+ +EL + D+G+G +++ S +ND +W V
Sbjct: 842 KE--------------DFIKLELKSATEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRVTA 887
Query: 594 QRDGRKGSISVNS-----RSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTA 648
+R+ ++ S+ V+ R P T L+L S+L++GG GG+
Sbjct: 888 ERNVKQASLQVDRLPQQIRKAP---TEGHTRLELYSQLFVGGA--GGQ------------ 930
Query: 649 ALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCAS--APCRNGGVCR 706
G++GC+R L ++G + DL A+ G CS C S C NGG C
Sbjct: 931 ---QGFLGCIRSLRMNGVTLDLEERAKVTS--GFISGCSGH----CTSYGTNCENGGKCL 981
Query: 707 EGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRF------ 760
E ++ + CDC T + G C ++ +G M+++ A T A D S R
Sbjct: 982 ERYHGYSCDCSNTAYDGTFCNKDVGAFFEEG-MWLRYNF-QAPATNARDSSSRVDNAPDQ 1039
Query: 761 ------MSQRAYGLMMATTSRES----ADTLRLELDGGQMKLTVNLDCLRVGCAPSKGPE 810
++Q +TT + + +K T +L +R ++ P
Sbjct: 1040 QNSHPDLAQEEIRFSFSTTKAPCILLYISSFTTDFLAVLVKPTGSLQ-IRYNLGGTREPY 1098
Query: 811 TLFAGHK-LNDNEWHTVRVVRRGKSLQLSVDN 841
+ H+ + + + H+V + R K++ L +D+
Sbjct: 1099 NIDVDHRNMANGQPHSVNITRHEKTIFLKLDH 1130
Score = 57.0 bits (136), Expect = 2e-07
Identities = 110/498 (22%), Positives = 189/498 (37%), Gaps = 71/498 (14%)
Query: 35 PGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLS 94
P + ++ + G S+ ++SF +T + +L++ G DF++L L + F+
Sbjct: 806 PSSYLHFSTFQGETSA-DISFYFKTLTPWGV--FLENMGKEDFIKLELKSAT-EVSFSFD 861
Query: 95 CAE---PATLQLDTPVADDRWHMVLLTRDARRTALAVD---GEARAAEVRSKRREMQVAS 148
++ TP+ DD+WH V R+ ++ +L VD + R A R +++ S
Sbjct: 862 VGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTR-LELYS 920
Query: 149 DLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGATADPLCAP 208
LFVGG S R L L ER A + S + G + C
Sbjct: 921 QLFVGGAGGQQGFLGCIRS-------LRMNGVTLDLEER--AKVTSGFISGCSGH--CTS 969
Query: 209 ARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEG 268
C NGG C G CDCS+T + G FC N +VG+ F EG
Sbjct: 970 YGTNCENGGKCLERYHG-YSCDCSNTAYDGTFC---------------NKDVGA-FFEEG 1012
Query: 269 GAGRGGAGDVHQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLML 328
R + P + + D ++ + +EI +F T + ++L
Sbjct: 1013 MWLR---YNFQAPATNARDSSSRVDN----APDQQNSHPDLAQEEIRFSFSTTKAPCILL 1065
Query: 329 HTGK-SADYVNLSLK-SGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHA 386
+ + D++ + +K +G++ + NLG ++ + + H V +TR+ +
Sbjct: 1066 YISSFTTDFLAVLVKPTGSLQIRYNLGGTREPYNIDVDHRNMANGQPHSVNITRHEK--- 1122
Query: 387 GIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNN 446
+ KL + ++S T+ S ++G T + N
Sbjct: 1123 ----TIFLKLDHYPSVSYH-------LPSSSDTLFNSPKSLFLGKVIETGKIDQEIHKYN 1171
Query: 447 ---FMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAF 503
F GCL V + N L+ + + +QG+L E P+T SP +
Sbjct: 1172 TPGFTGCLSRVQF-NQIAPLKAALRQTNASAHVHIQGEL---VESNCGASPLTL-SPMSS 1226
Query: 504 VALPRWSAKRTGSISLDF 521
P W S S DF
Sbjct: 1227 ATDP-WHLDHLDSASADF 1243
Score = 46.2 bits (108), Expect = 3e-04
Identities = 41/201 (20%), Positives = 81/201 (40%), Gaps = 19/201 (9%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTP--VADD 110
+SF RT LL++ + +E+ L + ++ + ++ + + + + + + D
Sbjct: 397 VSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDG 456
Query: 111 RWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVK 170
+WH V L +DG+ +A + +++ F GG + S+ ++
Sbjct: 457 QWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSV---- 512
Query: 171 YEPPFRGL---------LANL-KLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCT 220
+P F+G L NL ++ +R P + + C P N C +GG C+
Sbjct: 513 LQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSIDMCAIIDRCVP--NHCEHGGKCS 570
Query: 221 VLAPGEVGCDCSHTGFGGKFC 241
C C TG+ G C
Sbjct: 571 -QTWDSFKCTCDETGYSGATC 590
Score = 38.9 bits (89), Expect = 0.043
Identities = 100/431 (23%), Positives = 168/431 (38%), Gaps = 74/431 (17%)
Query: 755 DVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFA 814
D+S F + +G+ + +E D ++LEL +++ + D VG P + + +
Sbjct: 822 DISFYFKTLTPWGVFLENMGKE--DFIKLELKSAT-EVSFSFD---VGNGPVE--IVVRS 873
Query: 815 GHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMA--GAHMRLEFHN--IETGIMTERRF 870
LND++WH V R K L VD + + + A H RLE ++ G ++ F
Sbjct: 874 PTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTRLELYSQLFVGGAGGQQGF 933
Query: 871 ISVVPSNFI---------------GHLSGLVFNGQPYMDQCKDG---------------- 899
+ + S + G +SG + Y C++G
Sbjct: 934 LGCIRSLRMNGVTLDLEERAKVTSGFISGCSGHCTSYGTNCENGGKCLERYHGYSCDCSN 993
Query: 900 ---DITYC--ELNARF----GLRAIVADPVT-FKSRSSYLALATLQA-----YASMHLFF 944
D T+C ++ A F LR P T + SS + A Q A + F
Sbjct: 994 TAYDGTFCNKDVGAFFEEGMWLRYNFQAPATNARDSSSRVDNAPDQQNSHPDLAQEEIRF 1053
Query: 945 QFKTTAPDGLLLFNSGNGNDFIVIELVK--GYIHYVFDLGNGPSLMKGNSD-KPVNDNQW 1001
F TT +LL+ S DF+ + LVK G + ++LG + D + + + Q
Sbjct: 1054 SFSTTKAPCILLYISSFTTDFLAV-LVKPTGSLQIRYNLGGTREPYNIDVDHRNMANGQP 1112
Query: 1002 HNVVVSRDPGNVHTLKIDS-RTVTQH--SNGARNLDLKGELYIGGLSKNMFSNLPKLVAS 1058
H+V ++R + LK+D +V+ H S+ + L++G + + + +
Sbjct: 1113 HSVNITRHEKTIF-LKLDHYPSVSYHLPSSSDTLFNSPKSLFLGKVIETGKIDQEIHKYN 1171
Query: 1059 RDGFQGCLASVDLNGRLPDLIA-------DALHRIGQ-VERGCDGPSTTCTEESCANQGV 1110
GF GCL+ V N P A +H G+ VE C T + S A
Sbjct: 1172 TPGFTGCLSRVQFNQIAPLKAALRQTNASAHVHIQGELVESNCGASPLTLSPMSSATDPW 1231
Query: 1111 CLQQWDGFTCD 1121
L D + D
Sbjct: 1232 HLDHLDSASAD 1242
Score = 37.4 bits (85), Expect = 0.13
Identities = 26/98 (26%), Positives = 48/98 (48%), Gaps = 6/98 (6%)
Query: 1608 HLPTANPTGPGERGPPGAVEV-IRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEG 1666
HL +A+ P G A+ + +S+ G V+ +V LC L+ L +Y R +G
Sbjct: 1235 HLDSASADFPYNPGQGQAIRNGVNRNSAIIGGVIAVVIFTILCTLVFLI---RYMFRHKG 1291
Query: 1667 SYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKK 1704
+Y ++++ + SA+S A + P +T ++KK
Sbjct: 1292 TYHTNEAKG--AESAESADAAIMNNDPNFTETIDESKK 1327
>gi|18640734 contactin associated protein-like 5 [Homo sapiens]
Length = 1306
Score = 120 bits (300), Expect = 1e-26
Identities = 129/489 (26%), Positives = 210/489 (42%), Gaps = 64/489 (13%)
Query: 920 VTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVK-GYIHYV 978
V+F + +SYL T A S + F FKTTA G+ L N G DFI +E+ I +
Sbjct: 793 VSFYTEASYLHFPTFHAEFSADISFFFKTTALSGVFLENLGI-KDFIRLEISSPSEITFA 851
Query: 979 FDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS---RTVTQHSNGARNLDL 1035
D+GNGP + S +NDNQWH V R+ +L++D+ T G L L
Sbjct: 852 IDVGNGPVELVVQSPSLLNDNQWHYVRAERNLKET-SLQVDNLPRSTRETSEEGHFRLQL 910
Query: 1036 KGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDG 1095
+L++GG S + GF GC+ S+ LNG+ DL A G V GC G
Sbjct: 911 NSQLFVGGTSSR-----------QKGFLGCIRSLHLNGQKMDLEERAKVTSG-VRPGCPG 958
Query: 1096 PSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCN-------DPGT--TYIF----- 1141
++ C N G C+++ +G+ CDCT + Y GP C + GT TY+F
Sbjct: 959 HCSSYGS-ICHNGGKCVEKHNGYLCDCTNSPYEGPFCKKEVSAVFEAGTSVTYMFQEPYP 1017
Query: 1142 -GKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDY-LQLHIDQGT 1199
K +L + + PS + +A+ F T Q ++L+ ++S+S D+ + L G+
Sbjct: 1018 VTKNISLSSSAIYTDSAPS--KENIALSFVTTQAPSLLLFINSSS--QDFVVVLLCKNGS 1073
Query: 1200 VGVIFNVGTDD---ITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFD 1256
+ V +++ ++ TID N ++ + H ++ R G T+Q+D
Sbjct: 1074 LQVRYHLNKEETHVFTIDADN--FANRRMHHLKINREGRELTIQMD-------------- 1117
Query: 1257 NERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYN 1316
++L ++ P RV+ L K + +S+ A + F G +S + YN
Sbjct: 1118 -QQLRLSYNFSPEVEFRVIRSLTLGKVTENLGLDSEVA-----KANAMGFAGCMSSVQYN 1171
Query: 1317 GLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTT 1376
+ L A H L ++ ++ A T + + +T T
Sbjct: 1172 HIAPLKAALRHATVAPVTVHGTLTESSCGFMVDSDVNAVTTVHSSSDPFGKTDEREPLTN 1231
Query: 1377 TRRGRSPTL 1385
R S +
Sbjct: 1232 AVRSDSAVI 1240
Score = 112 bits (281), Expect = 2e-24
Identities = 104/420 (24%), Positives = 175/420 (41%), Gaps = 20/420 (4%)
Query: 726 CEREATVLSYDGSMYMKIMLPNAMHTEAEDV-SLRFMSQRAYGLMMATTSRESADTLRLE 784
C ++ V +DG + + + +DV SL+F S + G++ + D + LE
Sbjct: 174 CSYKSDVADFDGRSSLLYRFNQKLMSTLKDVISLKFKSMQGDGVLFHGEGQRG-DHITLE 232
Query: 785 LDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTV 844
L G++ L +NL + + S TL G L+D WH+V + R GK + +VD T
Sbjct: 233 LQKGRLALHLNLGDSKARLSSSLPSATL--GSLLDDQHWHSVLIERVGKQVNFTVDKHTQ 290
Query: 845 EGQMAGAH--MRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDIT 902
+ G + +++ GI + + + NF G + L +NG +D K
Sbjct: 291 HFRTKGETDALDIDYELSFGGIPVPGKPGTFLKKNFHGCIENLYYNGVNIIDLAKRRKHQ 350
Query: 903 YCELNARFGLRAIVADPVTF-KSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS-G 960
N F P+TF S SYL L + + FQF+T DGLLL
Sbjct: 351 IYTGNVTFSCSEPQIVPITFVNSSGSYLLLPGTPQIDGLSVSFQFRTWNKDGLLLSTELS 410
Query: 961 NGNDFIVIELVKGYIHYVFD--LGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKI 1018
G+ +++ L G + V ++ G++ +ND WH+V ++ + TL +
Sbjct: 411 EGSGTLLLSLEGGILRLVIQKMTERVAEILTGSN---LNDGLWHSVSINARRNRI-TLTL 466
Query: 1019 DSRTVTQHSNGARNLDLKGE-LYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPD 1077
D + G Y GG N+ + + + FQGC+ + ++ + D
Sbjct: 467 DDEAAPPAPDSTWVQIYSGNSYYFGGCPDNLTDS--QCLNPIKAFQGCMRLIFIDNQPKD 524
Query: 1078 LIA---DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCND 1134
LI+ +L + C C + G C Q W F C+C+ TSY G C++
Sbjct: 525 LISVQQGSLGNFSDLHIDLCSIKDRCLPNYCEHGGSCSQSWTTFYCNCSDTSYTGATCHN 584
Score = 110 bits (275), Expect = 1e-23
Identities = 114/451 (25%), Positives = 196/451 (43%), Gaps = 61/451 (13%)
Query: 289 VATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH-TGKSADYVNLSLKSGAVW 347
VA F G Y + + + D I+L F+++Q +G++ H G+ D++ L L+ G +
Sbjct: 180 VADFDGRSSLLYRFNQKLMSTLKDVISLKFKSMQGDGVLFHGEGQRGDHITLELQKGRLA 239
Query: 348 LVINLGSGAFE---ALVEPVNGKF-NDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTIS 403
L +NLG +L G +D WH V + R +Q V +
Sbjct: 240 LHLNLGDSKARLSSSLPSATLGSLLDDQHWHSVLIERVGKQ---------------VNFT 284
Query: 404 VDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKL 463
VD T T+ + L D GG P PG+ + NF GC++++ Y +
Sbjct: 285 VDKH-TQHFRTKGETDALDIDYELSFGGIP-VPGKPGTFLKKNFHGCIENLYYNG----V 338
Query: 464 ELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTF-ESPEAFVALPRWSAKRTGSISLDFR 522
+ LAK ++ G+++F C + + P+TF S +++ LP S+S FR
Sbjct: 339 NIIDLAKRRKHQI-YTGNVTFSCSEPQIV-PITFVNSSGSYLLLPGTPQIDGLSVSFQFR 396
Query: 523 TTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRK 582
T +GLLL ++ G+G+ + L G L L++ + + +
Sbjct: 397 TWNKDGLLLSTE---LSEGSGT---------LLLSLEGGILRLVIQKMTERVAEILTGSN 444
Query: 583 VNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLES--ELYLGGLPEGGRVDLP 640
+NDG W V + +++++ + P DS + + S Y GG P+
Sbjct: 445 LNDGLWHSVSINARRNRITLTLDDEAAP--PAPDSTWVQIYSGNSYYFGGCPDNLTDSQC 502
Query: 641 LPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGV-----APFCSRETLKQCA 695
L P ++A + GC+R +FID + +DL ++ QG++G CS + +C
Sbjct: 503 LNP------IKA-FQGCMRLIFIDNQPKDL--ISVQQGSLGNFSDLHIDLCSIKD--RCL 551
Query: 696 SAPCRNGGVCREGWNRFICDCIGTGFLGRVC 726
C +GG C + W F C+C T + G C
Sbjct: 552 PNYCEHGGSCSQSWTTFYCNCSDTSYTGATC 582
Score = 92.0 bits (227), Expect = 4e-18
Identities = 84/370 (22%), Positives = 171/370 (46%), Gaps = 69/370 (18%)
Query: 495 VTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYF 554
V+F + +++ P + A+ + IS F+TT +G+ L + G + D+
Sbjct: 793 VSFYTEASYLHFPTFHAEFSADISFFFKTTALSGVFLENLGIK--------------DFI 838
Query: 555 AMELLD-GHLYLLLDMGSGGIKLRASSRKV-NDGEWCHVDFQRDGRKGSISVNS--RSTP 610
+E+ + +D+G+G ++L S + ND +W +V +R+ ++ S+ V++ RST
Sbjct: 839 RLEISSPSEITFAIDVGNGPVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTR 898
Query: 611 FLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDL 670
+ L L S+L++GG T++ + G++GC+R L ++G+ DL
Sbjct: 899 ETSEEGHFRLQLNSQLFVGG----------------TSSRQKGFLGCIRSLHLNGQKMDL 942
Query: 671 RGLAEAQGAVGVAPFCSRETLKQCAS--APCRNGGVCREGWNRFICDCIGTGFLGRVCER 728
A+ GV P C C+S + C NGG C E N ++CDC + + G C++
Sbjct: 943 EERAKVTS--GVRPGCPGH----CSSYGSICHNGGKCVEKHNGYLCDCTNSPYEGPFCKK 996
Query: 729 EATVLSYDGS----MYMK--------IMLPNAMHTEA----EDVSLRFMSQRAYGLMMAT 772
E + + G+ M+ + + +A++T++ E+++L F++ +A L++
Sbjct: 997 EVSAVFEAGTSVTYMFQEPYPVTKNISLSSSAIYTDSAPSKENIALSFVTTQAPSLLLFI 1056
Query: 773 TSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFA--GHKLNDNEWHTVRVVR 830
S + L G +++ +L +K +F + H +++ R
Sbjct: 1057 NSSSQDFVVVLLCKNGSLQVRYHL---------NKEETHVFTIDADNFANRRMHHLKINR 1107
Query: 831 RGKSLQLSVD 840
G+ L + +D
Sbjct: 1108 EGRELTIQMD 1117
Score = 57.0 bits (136), Expect = 2e-07
Identities = 55/207 (26%), Positives = 92/207 (44%), Gaps = 27/207 (13%)
Query: 47 AASSGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAE-PATLQLDT 105
A S ++SF +T A + +L++ G DF+ L + + F + P L + +
Sbjct: 809 AEFSADISFFFKTTALSGV--FLENLGIKDFIRLE-ISSPSEITFAIDVGNGPVELVVQS 865
Query: 106 P--VADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRR--EMQVASDLFVGGIPPDVRL 161
P + D++WH V R+ + T+L VD R+ S+ +Q+ S LFVGG
Sbjct: 866 PSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRETSEEGHFRLQLNSQLFVGG------- 918
Query: 162 SALTLSTVKYEPPFRGLLANLKLGERPPAL----LGSQGLRGATADPLCAPARNPCANGG 217
T + F G + +L L + L + G+R C+ + C NGG
Sbjct: 919 ------TSSRQKGFLGCIRSLHLNGQKMDLEERAKVTSGVRPGCPGH-CSSYGSICHNGG 971
Query: 218 LCTVLAPGEVGCDCSHTGFGGKFCSEE 244
C G + CDC+++ + G FC +E
Sbjct: 972 KCVEKHNGYL-CDCTNSPYEGPFCKKE 997
Score = 52.8 bits (125), Expect = 3e-06
Identities = 92/387 (23%), Positives = 154/387 (39%), Gaps = 79/387 (20%)
Query: 750 HTE-AEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKG 808
H E + D+S F + G+ + + D +RLE+ ++T +D G
Sbjct: 808 HAEFSADISFFFKTTALSGVFLENLGIK--DFIRLEISSPS-EITFAIDV-------GNG 857
Query: 809 PETLFAGHK--LNDNEWHTVRVVRRGKSLQLSVDNV---TVEGQMAGAHMRLEFHN-IET 862
P L LNDN+WH VR R K L VDN+ T E G H RL+ ++ +
Sbjct: 858 PVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRETSEEG-HFRLQLNSQLFV 916
Query: 863 GIMTERRFISVVPSNFIGHLSGLVFNGQP-----------------------YMDQCKDG 899
G + R+ F+G + L NGQ Y C +G
Sbjct: 917 GGTSSRQ------KGFLGCIRSLHLNGQKMDLEERAKVTSGVRPGCPGHCSSYGSICHNG 970
Query: 900 ------------DIT-------YC--ELNARFGLRAIVAD------PVTFKSRSSYLALA 932
D T +C E++A F V PVT S A+
Sbjct: 971 GKCVEKHNGYLCDCTNSPYEGPFCKKEVSAVFEAGTSVTYMFQEPYPVTKNISLSSSAIY 1030
Query: 933 TLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVK-GYIHYVFDLGNGPSLMKGN 991
T A + ++ F TT LLLF + + DF+V+ L K G + + L + +
Sbjct: 1031 TDSAPSKENIALSFVTTQAPSLLLFINSSSQDFVVVLLCKNGSLQVRYHLNKEETHVFTI 1090
Query: 992 SDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLK--GELYIGGLSKNMF 1049
+ + H++ ++R+ G T+++D + + N + ++ + L +G +++N+
Sbjct: 1091 DADNFANRRMHHLKINRE-GRELTIQMDQQLRLSY-NFSPEVEFRVIRSLTLGKVTENLG 1148
Query: 1050 SNLPKLVASRDGFQGCLASVDLNGRLP 1076
+ A+ GF GC++SV N P
Sbjct: 1149 LDSEVAKANAMGFAGCMSSVQYNHIAP 1175
Score = 49.3 bits (116), Expect = 3e-05
Identities = 40/160 (25%), Positives = 74/160 (46%), Gaps = 28/160 (17%)
Query: 313 EITLAFRTLQRNGLMLHTGKSADYVNLSLKSGA-VWLVINLGSGAFEALVEPVNGKFNDN 371
+I+ F+T +G+ L D++ L + S + + I++G+G E +V+ + NDN
Sbjct: 814 DISFFFKTTALSGVFLENLGIKDFIRLEISSPSEITFAIDVGNGPVELVVQSPS-LLNDN 872
Query: 372 AWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQED-YTMLGSDDFFYIG 430
WH VR RNL++ ++ VD + +T T E+ + L + ++G
Sbjct: 873 QWHYVRAERNLKE---------------TSLQVDNLPRSTRETSEEGHFRLQLNSQLFVG 917
Query: 431 GSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAK 470
G+ S F+GC++ + N K++L AK
Sbjct: 918 GT--------SSRQKGFLGCIRSL--HLNGQKMDLEERAK 947
Score = 48.1 bits (113), Expect = 7e-05
Identities = 57/237 (24%), Positives = 88/237 (37%), Gaps = 17/237 (7%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRW 112
+SF RT LLL + L L L G LRL A + + + D W
Sbjct: 391 VSFQFRTWNKDGLLLSTELSEGSGTLLLSLEGGILRLVIQKMTERVAEILTGSNLNDGLW 450
Query: 113 HMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYE 172
H V + R L +D EA S ++ + + GG PD + L+ +K
Sbjct: 451 HSVSINARRNRITLTLDDEAAPPAPDSTWVQIYSGNSYYFGGC-PDNLTDSQCLNPIK-- 507
Query: 173 PPFRGLLANLKLGERPPALLG-SQGLRGATAD---------PLCAPARNPCANGGLCTVL 222
F+G + + + +P L+ QG G +D C P N C +GG C+
Sbjct: 508 -AFQGCMRLIFIDNQPKDLISVQQGSLGNFSDLHIDLCSIKDRCLP--NYCEHGGSCS-Q 563
Query: 223 APGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVH 279
+ C+CS T + G C + + + G G+G G V+
Sbjct: 564 SWTTFYCNCSDTSYTGATCHNSIYEQSCEVYRHQGNTAGFFYIDSDGSGPLGPLQVY 620
Score = 37.7 bits (86), Expect = 0.097
Identities = 34/157 (21%), Positives = 63/157 (40%), Gaps = 9/157 (5%)
Query: 7 WRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALL 66
W P+ + + + + ++D +F G R+ + + +S ++ +L
Sbjct: 159 WNPSGKIGMRVEVYGCSYKSDVADFDGRSSLLYRFNQKLMSTLKDVISLKFKSMQGDGVL 218
Query: 67 LYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVA-------DDRWHMVLLTR 119
+ +G D + L L GRL L L ++ A L P A D WH VL+ R
Sbjct: 219 FH-GEGQRGDHITLELQKGRLALHLNLGDSK-ARLSSSLPSATLGSLLDDQHWHSVLIER 276
Query: 120 DARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIP 156
++ VD + + + + + +L GGIP
Sbjct: 277 VGKQVNFTVDKHTQHFRTKGETDALDIDYELSFGGIP 313
>gi|148664242 cell recognition protein CASPR4 isoform 2 [Homo sapiens]
Length = 1235
Score = 116 bits (291), Expect = 2e-25
Identities = 99/343 (28%), Positives = 159/343 (46%), Gaps = 39/343 (11%)
Query: 921 TFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKG-YIHYVF 979
+F + +SYL T S + F FKTTA G+ L N G DFI IEL + + F
Sbjct: 723 SFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIA-DFIRIELRSPTVVTFSF 781
Query: 980 DLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS---RTVTQHSNGARNLDLK 1036
D+GNGP + S NDNQWH+V V R+ +L++D +T ++G L L
Sbjct: 782 DVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEA-SLQVDQLTPKTQPAPADGHVLLQLN 840
Query: 1037 GELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGP 1096
+L++GG + + GF GC+ S+ LNG DL + +V+ GC G
Sbjct: 841 SQLFVGGTATR-----------QRGFLGCIRSLQLNGMTLDL-EERAQVTPEVQPGCRGH 888
Query: 1097 STTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALI-----TYT 1151
++ + C N G C ++ GF CDCT ++Y GP C++ + Y FG G ++I Y
Sbjct: 889 CSSYGK-LCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAY-FGSGSSVIYNFQENYL 946
Query: 1152 WPPND-------RPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI-DQGTVGVI 1203
N ++ R + FS + + +S +YL + I G++ +
Sbjct: 947 LSKNSSSHAASFHGDMKLSREMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIR 1006
Query: 1204 FNVG----TDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1242
+ + D + D N ++DG+ H + R G +++D
Sbjct: 1007 YKLNKYQEPDVVNFDFKN--MADGQLHHIMINREEGVVFIEID 1047
Score = 105 bits (262), Expect = 4e-22
Identities = 105/430 (24%), Positives = 163/430 (37%), Gaps = 88/430 (20%)
Query: 726 CEREATVLSYDGSMYMKIMLPNAMHTEAEDV-SLRFMSQRAYGLMMATTSRESADTLRLE 784
C + V+ DG + + +D+ SL+F + ++ G+++ + D + L+
Sbjct: 152 CAYRSEVVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREG-PNGDHITLQ 210
Query: 785 LDGGQMKLTVNLDCLRVGCAPSKGPET-----LFAGHKLNDNEWHTVRVVRRGKSLQLSV 839
L ++ L +N +K P T L G L+D WH+V + R GK +
Sbjct: 211 LRRARLFLLIN-------SGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQRLGKQV---- 259
Query: 840 DNVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDG 899
N TV+ H R EF+ L L + G
Sbjct: 260 -NFTVDEHRHHFHARGEFN-----------------------LMNLDYEG---------- 285
Query: 900 DITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS 959
N F + PVTF S SYLAL + FQF+T GLLLF+
Sbjct: 286 -------NVSFSCSQPQSMPVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSE 338
Query: 960 GNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKP------------VNDNQWHNVVVS 1007
++L+ G I G +K N +P +ND QWH+V +S
Sbjct: 339 --------LQLISGGILLFLSDGK----LKSNLYQPGKLPSDITAGVELNDGQWHSVSLS 386
Query: 1008 RDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLA 1067
++ G + G Y GG F + K + GFQGC+
Sbjct: 387 AKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGS--KCKSPLGGFQGCMR 444
Query: 1068 SVDLNGRLPDLIA---DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTM 1124
+ ++G++ DLI+ +L ++ G S C C + G C Q W F C+CT
Sbjct: 445 LISISGKVVDLISVQQGSLGNFSDLQIDSCGISDRCLPNYCEHGGECSQSWSTFHCNCTN 504
Query: 1125 TSYGGPVCND 1134
T Y G C++
Sbjct: 505 TGYRGATCHN 514
Score = 87.0 bits (214), Expect = 1e-16
Identities = 69/254 (27%), Positives = 110/254 (43%), Gaps = 31/254 (12%)
Query: 479 QGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRA 538
+G++SF C ++ PVTF S +++ALP +S + S + FRT GLLLFS+ +
Sbjct: 284 EGNVSFSCSQPQSM-PVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSELQLI 342
Query: 539 GGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGR 598
GG + L DG L L + ++NDG+W V
Sbjct: 343 SGG------------ILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKN 390
Query: 599 KGSISVNSRSTPFLATGDSEILDLESELYLGGLPE---GGRVDLPLPPEVWTAALRAGYV 655
S++V+ + E + Y GG P+ G + PL G+
Sbjct: 391 HLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGSKCKSPL----------GGFQ 440
Query: 656 GCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETL---KQCASAPCRNGGVCREGWNRF 712
GC+R + I G+ DL ++ QG++G ++ +C C +GG C + W+ F
Sbjct: 441 GCMRLISISGKVVDL--ISVQQGSLGNFSDLQIDSCGISDRCLPNYCEHGGECSQSWSTF 498
Query: 713 ICDCIGTGFLGRVC 726
C+C TG+ G C
Sbjct: 499 HCNCTNTGYRGATC 512
Score = 86.3 bits (212), Expect = 2e-16
Identities = 73/267 (27%), Positives = 119/267 (44%), Gaps = 51/267 (19%)
Query: 479 QGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRA 538
QGD SF + +F++ +++ P + + + +S F+TT +G+ L + G
Sbjct: 713 QGDRSF-------WNSASFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGI-- 763
Query: 539 GGGAGSHSSAQRADYFAMELLDGHLYLL-LDMGSGGIKLRASS-RKVNDGEWCHVDFQRD 596
AD+ +EL + D+G+G ++ S ND +W HV +R+
Sbjct: 764 ------------ADFIRIELRSPTVVTFSFDVGNGPFEISVQSPTHFNDNQWHHVRVERN 811
Query: 597 GRKGSISVNS---RSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAG 653
++ S+ V+ ++ P A G +L L S+L++GG TA + G
Sbjct: 812 MKEASLQVDQLTPKTQPAPADGHV-LLQLNSQLFVGG----------------TATRQRG 854
Query: 654 YVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAP--CRNGGVCREGWNR 711
++GC+R L ++G + DL AQ V P C C+S CRNGG CRE
Sbjct: 855 FLGCIRSLQLNGMTLDLE--ERAQVTPEVQPGCRGH----CSSYGKLCRNGGKCRERPIG 908
Query: 712 FICDCIGTGFLGRVCEREATVLSYDGS 738
F CDC + + G C E + GS
Sbjct: 909 FFCDCTFSAYTGPFCSNEISAYFGSGS 935
Score = 67.8 bits (164), Expect = 9e-11
Identities = 97/388 (25%), Positives = 157/388 (40%), Gaps = 77/388 (19%)
Query: 755 DVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFA 814
DVS F + + G+ + AD +R+EL + +T + D VG P + ++ +
Sbjct: 743 DVSFFFKTTASSGVFLENLG--IADFIRIELRSPTV-VTFSFD---VGNGPFE--ISVQS 794
Query: 815 GHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGA--HMRLEFHN--IETGIMTERRF 870
NDN+WH VRV R K L VD +T + Q A A H+ L+ ++ G T +R
Sbjct: 795 PTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLFVGGTATRQR- 853
Query: 871 ISVVPSNFIGHLSGLVFNG---------------QP--------YMDQCKDG-------- 899
F+G + L NG QP Y C++G
Sbjct: 854 ------GFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGHCSSYGKLCRNGGKCRERPI 907
Query: 900 ----DITYCELNARFGLRAIVA-----DPVTFKSRSSYLALATLQAYA-SMH-------- 941
D T+ F I A V + + +YL ++A S H
Sbjct: 908 GFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMKLSRE 967
Query: 942 -LFFQFKTTAPDGLLLFNSGNGNDFIVIELVKG---YIHYVFDLGNGPSLMKGNSD-KPV 996
+ F F+TT LLLF S +++ + + K I Y + P ++ N D K +
Sbjct: 968 MIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIRYKLNKYQEPDVV--NFDFKNM 1025
Query: 997 NDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLV 1056
D Q H+++++R+ G V D+R H + L +G + ++ + +
Sbjct: 1026 ADGQLHHIMINREEGVVFIEIDDNRRRQVHLSSGTEFSAVKSLVLGRILEHSDVDQDTAL 1085
Query: 1057 ASRDGFQGCLASVDLNGRLPDLIADALH 1084
A GF GCL++V L+ P + ALH
Sbjct: 1086 AGAQGFTGCLSAVQLSHVAP--LKAALH 1111
Score = 50.8 bits (120), Expect = 1e-05
Identities = 37/154 (24%), Positives = 67/154 (43%), Gaps = 26/154 (16%)
Query: 313 EITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAV-WLVINLGSGAFEALVEPVNGKFNDN 371
+++ F+T +G+ L AD++ + L+S V ++G+G FE V+ FNDN
Sbjct: 743 DVSFFFKTTASSGVFLENLGIADFIRIELRSPTVVTFSFDVGNGPFEISVQSPT-HFNDN 801
Query: 372 AWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQED-YTMLGSDDFFYIG 430
WH VRV RN+++ ++ VD + T D + +L + ++G
Sbjct: 802 QWHHVRVERNMKE---------------ASLQVDQLTPKTQPAPADGHVLLQLNSQLFVG 846
Query: 431 GSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLE 464
G+ F+GC++ + LE
Sbjct: 847 GTATR--------QRGFLGCIRSLQLNGMTLDLE 872
Score = 48.1 bits (113), Expect = 7e-05
Identities = 54/232 (23%), Positives = 91/232 (39%), Gaps = 25/232 (10%)
Query: 54 SFSLRTNATRALLLY----LDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVAD 109
+F RT LLL+ L GG + L L DG+L+ P+ + + D
Sbjct: 322 TFQFRTWNKAGLLLFSELQLISGG----ILLFLSDGKLKSNLYQPGKLPSDITAGVELND 377
Query: 110 DRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTV 169
+WH V L+ ++AVDG+ +A ++ + GG PD + S +
Sbjct: 378 GQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGC-PDKSFGSKCKSPL 436
Query: 170 KYEPPFRGLLANLKLGERPPALLG-SQGLRGATAD---------PLCAPARNPCANGGLC 219
F+G + + + + L+ QG G +D C P N C +GG C
Sbjct: 437 ---GGFQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDSCGISDRCLP--NYCEHGGEC 491
Query: 220 TVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAG 271
+ + C+C++TG+ G C + A+ + G G+G
Sbjct: 492 S-QSWSTFHCNCTNTGYRGATCHNSIYEQSCEAYKHRGNTSGFYYIDSDGSG 542
Score = 48.1 bits (113), Expect = 7e-05
Identities = 54/208 (25%), Positives = 86/208 (41%), Gaps = 35/208 (16%)
Query: 50 SGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAE---PATLQLDTP 106
S ++SF +T A+ + +L++ G DF+ + L + + F+ ++Q T
Sbjct: 741 SADVSFFFKTTASSGV--FLENLGIADFIRIELRSPTV-VTFSFDVGNGPFEISVQSPTH 797
Query: 107 VADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRRE--MQVASDLFVGGIPPDVRLSAL 164
D++WH V + R+ + +L VD + +Q+ S LFVGG
Sbjct: 798 FNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLFVGG---------- 847
Query: 165 TLSTVKYEPPFRGLLANLKLG-------ERPPALLGSQ-GLRGATADPLCAPARNPCANG 216
T + F G + +L+L ER Q G RG C+ C NG
Sbjct: 848 ---TATRQRGFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGH-----CSSYGKLCRNG 899
Query: 217 GLCTVLAPGEVGCDCSHTGFGGKFCSEE 244
G C G CDC+ + + G FCS E
Sbjct: 900 GKCRERPIGFF-CDCTFSAYTGPFCSNE 926
Score = 47.4 bits (111), Expect = 1e-04
Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 5/97 (5%)
Query: 289 VATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH-TGKSADYVNLSLKSGAVW 347
V G Y + D I+L F+T+Q +G++LH G + D++ L L+ ++
Sbjct: 158 VVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREGPNGDHITLQLRRARLF 217
Query: 348 LVINLGSGAFEALVEPVN----GKFNDNAWHDVRVTR 380
L+IN G + VN +D WH V + R
Sbjct: 218 LLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQR 254
Score = 42.7 bits (99), Expect = 0.003
Identities = 33/117 (28%), Positives = 55/117 (47%), Gaps = 23/117 (19%)
Query: 517 ISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKL 576
ISL F+T + +G+LL H D+ ++L L+LL++ SG KL
Sbjct: 183 ISLKFKTMQSDGILL-------------HREGPNGDHITLQLRRARLFLLIN--SGEAKL 227
Query: 577 RASSRKVN--------DGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESE 625
++S VN D W V QR G++ + +V+ F A G+ +++L+ E
Sbjct: 228 PSTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRHHFHARGEFNLMNLDYE 284
>gi|38788416 laminin, alpha 1 precursor [Homo sapiens]
Length = 3075
Score = 116 bits (290), Expect = 2e-25
Identities = 167/806 (20%), Positives = 324/806 (40%), Gaps = 109/806 (13%)
Query: 300 YDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGK--SADYVNLSLKSGAVWLVINLGSGAF 357
Y + + ++ +I + F T NGL+L+ G + D++++ L G V ++ +LGSG
Sbjct: 2315 YSVVEKSLPATVTQIIMLFNTFSPNGLLLYLGSYGTKDFLSIELFRGRVKVMTDLGSGPI 2374
Query: 358 EALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQED 417
L + ++N+ W+ + RN +Q V +D T+ T++
Sbjct: 2375 TLLTDR---RYNNGTWYKIAFQRNRKQG--------------VLAVIDAYNTSNKETKQG 2417
Query: 418 YTMLGSDDF-------FYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAK 470
T S D Y+GG P + + + +F+GC+K++ + F L +
Sbjct: 2418 ETPGASSDLNRLDKDPIYVGGLPRSRVVRRGVTTKSFVGCIKNLEISRSTFDLLRN---- 2473
Query: 471 EGDPKMKLQGDLSFRCEDVAALDPVTFES--PEAFVALPRWSAKRTGSISLDFRTTEPNG 528
S+ L+P+ S ++ LP S + F TT +G
Sbjct: 2474 ------------SYGVRKGCLLEPIRSVSFLKGGYIELPPKSLSPESEWLVTFATTNSSG 2521
Query: 529 LLLFSQGRRAGGGAGSHSSAQRA--DYFAMELLDGHLYLLLDMGSG-GIK---LRASSRK 582
++L + GG + A +F++ L+ G++ + ++ G G G++ L A +
Sbjct: 2522 IILAA----LGGDVEKRGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTGT 2577
Query: 583 VNDGEWCHVDFQRDGRKGSISVNSRSTPFLATG---DSEILDLESELYLGGLPEGGRVDL 639
+DG+ + R+ R ++ ++ + + G +S +++ S LY+GG+PEG L
Sbjct: 2578 CSDGQAHSISLVRNRRIITVQLDENNPVEMKLGTLVESRTINV-SNLYVGGIPEGEGTSL 2636
Query: 640 PLPPEVWTAALRAGYVGCVRDLFIDGRSRDLR-GLAEAQGAVGVAPFCSRETLKQCASAP 698
+R + GC+++L + D + Q + R L AP
Sbjct: 2637 --------LTMRRSFHGCIKNLIFNLELLDFNSAVGHEQVDLDTCWLSERPKL-----AP 2683
Query: 699 CRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSL 758
F C+ L V L+ + + + ++S+
Sbjct: 2684 DAEDSKLLPEPRAFPEQCVVDAALEYVPGAHQFGLTQNSHFILPFNQSAVRKKLSVELSI 2743
Query: 759 RFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKL 818
R + + GL+ + AD L+L GG++ +L KG + L
Sbjct: 2744 RTFA--SSGLIYYMAHQNQADYAVLQLHGGRLHFMFDL---------GKGRTKVSHPALL 2792
Query: 819 NDNEWHTVRVVRRGKSLQLSVDN-----VTVEGQMAGAHMRLEFHNIETGIMTERRFISV 873
+D +WHTV+ + ++VD VTV G + F+ + R I
Sbjct: 2793 SDGKWHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGLFYLGGLPSQYQARKIGN 2852
Query: 874 VPSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALAT 933
+ + + + N + +D KD ++ +N + VA T+ S Y AL
Sbjct: 2853 ITHSIPACIGDVTVNSK-QLD--KDSPVSAFTVNRCYA----VAQEGTYFDGSGYAALVK 2905
Query: 934 --LQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNG----PSL 987
+ + +++ +F+T++ +G+LL S D I +ELV G + +F + NG +
Sbjct: 2906 EGYKVQSDVNITLEFRTSSQNGVLLGISTAKVDAIGLELVDGKV--LFHVNNGAGRITAA 2963
Query: 988 MKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHS--NGARNLDLKGELYIGGLS 1045
+ + + D +WH + ++ + TL +D V S + ++D +Y+GG
Sbjct: 2964 YEPKTATVLCDGKWHTLQANKSKHRI-TLIVDGNAVGAESPHTQSTSVDTNNPIYVGGYP 3022
Query: 1046 KNMFSNLPKLVASRDGFQGCLASVDL 1071
+ K + S+ F+GCL + L
Sbjct: 3023 AGV---KQKCLRSQTSFRGCLRKLAL 3045
Score = 105 bits (262), Expect = 4e-22
Identities = 219/1025 (21%), Positives = 378/1025 (36%), Gaps = 226/1025 (22%)
Query: 303 SHNPIQSSTD--EITLAFRTLQRNGLMLHTGKS--ADYVNLSLKSGAVWLVINLGSGAFE 358
++ P SST+ +TL +T + + L+ + G S +D++ + ++ G V + +LGSG+
Sbjct: 2129 AYQPQISSTNYNTLTLNVKTQEPDNLLFYLGSSTASDFLAVEMRRGRVAFLWDLGSGSTR 2188
Query: 359 ALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDY 418
+E + +DN WH + V R IG V ++ + T+ +
Sbjct: 2189 --LEFPDFPIDDNRWHSIHVAR----FGNIGSLSVKEMS---SNQKSPTKTSKSPGTANV 2239
Query: 419 TMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKL 478
+ + ++GG + +F GCL + L + + +EG K
Sbjct: 2240 LDVNNSTLMFVGGLGGQIKKSPAVKVTHFKGCLGEAFLNGKSIGL-WNYIEREG----KC 2294
Query: 479 QGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRA 538
+G + DP + + + I + F T PNGLLL+
Sbjct: 2295 RGCFGSSQNE----DPSFHFDGSGYSVVEKSLPATVTQIIMLFNTFSPNGLLLY------ 2344
Query: 539 GGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGR 598
GS+ + D+ ++EL G + ++ D+GSG I L + R+ N+G W + FQR+ +
Sbjct: 2345 ---LGSYGT---KDFLSIELFRGRVKVMTDLGSGPITL-LTDRRYNNGTWYKIAFQRNRK 2397
Query: 599 KGSISV-NSRSTPFLATGDSEILDLESEL--------YLGGLPEGGRVDLPLPPEVWTAA 649
+G ++V ++ +T T E S+L Y+GGLP RV V
Sbjct: 2398 QGVLAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLPR-SRV-------VRRGV 2449
Query: 650 LRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGW 709
+VGC+++L I + DL + + GV K C P R+ + G+
Sbjct: 2450 TTKSFVGCIKNLEISRSTFDL-----LRNSYGVR--------KGCLLEPIRSVSFLKGGY 2496
Query: 710 NRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLM 769
I LP + + + F + + G++
Sbjct: 2497 ---------------------------------IELPPKSLSPESEWLVTFATTNSSGII 2523
Query: 770 MATT--------SRESADT--LRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFA-GHKL 818
+A RE A + L GG +++ VN G L A
Sbjct: 2524 LAALGGDVEKRGDREEAHVPFFSVMLIGGNIEVHVN-----PGDGTGLRKALLHAPTGTC 2578
Query: 819 NDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHMRLEFHNIE------------TGIMT 866
+D + H++ +VR + + + +D G + N+ T ++T
Sbjct: 2579 SDGQAHSISLVRNRRIITVQLDENNPVEMKLGTLVESRTINVSNLYVGGIPEGEGTSLLT 2638
Query: 867 ERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGL------RAIVADPV 920
RR N I +L L FN +Q D+ C L+ R L ++ +P
Sbjct: 2639 MRRSFHGCIKNLIFNLELLDFNSAVGHEQV---DLDTCWLSERPKLAPDAEDSKLLPEPR 2695
Query: 921 TFKSRSSYLALATLQAYASMHLF------------------------FQFKTTAPDGLLL 956
F + + A L+ H F +T A GL+
Sbjct: 2696 AFPEQC--VVDAALEYVPGAHQFGLTQNSHFILPFNQSAVRKKLSVELSIRTFASSGLIY 2753
Query: 957 FNS-GNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVS--RDPGNV 1013
+ + N D+ V++L G +H++FDLG G + K + ++D +WH V + G +
Sbjct: 2754 YMAHQNQADYAVLQLHGGRLHFMFDLGKGRT--KVSHPALLSDGKWHTVKTDYVKRKGFI 2811
Query: 1014 HTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNG 1073
+S VT +G LD++G Y+GGL + K+ C+ V +N
Sbjct: 2812 TVDGRESPMVTVVGDGTM-LDVEGLFYLGGLPSQYQAR--KIGNITHSIPACIGDVTVNS 2868
Query: 1074 RLPDLIADALHRIGQVERGCDGPSTTCTEESC---ANQGVCLQQWDGFTCDCTMTSYGGP 1130
+ D D P + T C A +G
Sbjct: 2869 KQLDK---------------DSPVSAFTVNRCYAVAQEG--------------------- 2892
Query: 1131 VCNDPGTTYIFGKGGALITYTWPPNDRPSTRMD-RLAVGFSTHQRSAVLVRVDSASGLGD 1189
TY G G A + + + D + + F T ++ VL+ + +A D
Sbjct: 2893 -------TYFDGSGYAALV-----KEGYKVQSDVNITLEFRTSSQNGVLLGISTAK--VD 2938
Query: 1190 YLQLHIDQGTVGVIFNVGTDDITID-EPN--AIVSDGKYHVVRFTRSGGNATLQVDSWPV 1246
+ L + G V N G IT EP ++ DGK+H ++ +S TL VD V
Sbjct: 2939 AIGLELVDGKVLFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNAV 2998
Query: 1247 NERYP 1251
P
Sbjct: 2999 GAESP 3003
Score = 46.6 bits (109), Expect = 2e-04
Identities = 46/173 (26%), Positives = 69/173 (39%), Gaps = 17/173 (9%)
Query: 23 AARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGGDCDFLELLL 82
A +G F G G A S ++ RT++ +LL + D + L L
Sbjct: 2887 AVAQEGTYFDGS-GYAALVKEGYKVQSDVNITLEFRTSSQNGVLLGISTA-KVDAIGLEL 2944
Query: 83 VDGRLRLRFT------LSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAE 136
VDG++ + EP T T + D +WH + + R L VDG A AE
Sbjct: 2945 VDGKVLFHVNNGAGRITAAYEPKTA---TVLCDGKWHTLQANKSKHRITLIVDGNAVGAE 3001
Query: 137 -VRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERP 188
++ + + ++VGG P V+ L T FRG L L L + P
Sbjct: 3002 SPHTQSTSVDTNNPIYVGGYPAGVKQKCLRSQT-----SFRGCLRKLALIKSP 3049
Score = 45.8 bits (107), Expect = 4e-04
Identities = 47/171 (27%), Positives = 74/171 (43%), Gaps = 21/171 (12%)
Query: 48 ASSGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPV 107
A+ ++ T + LLLYL G DFL + L GR+++ L + P TL D
Sbjct: 2324 ATVTQIIMLFNTFSPNGLLLYLGSYGTKDFLSIELFRGRVKVMTDLG-SGPITLLTDRRY 2382
Query: 108 ADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASD---------LFVGGIPPD 158
+ W+ + R+ ++ LAV + +K+ E AS ++VGG+P
Sbjct: 2383 NNGTWYKIAFQRNRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLPRS 2442
Query: 159 --VRLSALTLSTVKYEPPFRGLLANLKLGERPPALL-GSQGLR-GATADPL 205
VR T S F G + NL++ LL S G+R G +P+
Sbjct: 2443 RVVRRGVTTKS-------FVGCIKNLEISRSTFDLLRNSYGVRKGCLLEPI 2486
Score = 39.7 bits (91), Expect = 0.025
Identities = 31/110 (28%), Positives = 47/110 (42%), Gaps = 12/110 (10%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTL-----SCAEPATLQLDTPV 107
+ S+RT A+ L+ Y+ D+ L L GRL F L + PA L
Sbjct: 2739 VELSIRTFASSGLIYYMAHQNQADYAVLQLHGGRLHFMFDLGKGRTKVSHPALL------ 2792
Query: 108 ADDRWHMVLLTRDARRTALAVDG-EARAAEVRSKRREMQVASDLFVGGIP 156
+D +WH V R+ + VDG E+ V + V ++GG+P
Sbjct: 2793 SDGKWHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGLFYLGGLP 2842
Score = 35.8 bits (81), Expect = 0.37
Identities = 21/76 (27%), Positives = 35/76 (46%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRW 112
L+ +++T LL YL DFL + + GR+ + L D P+ D+RW
Sbjct: 2142 LTLNVKTQEPDNLLFYLGSSTASDFLAVEMRRGRVAFLWDLGSGSTRLEFPDFPIDDNRW 2201
Query: 113 HMVLLTRDARRTALAV 128
H + + R +L+V
Sbjct: 2202 HSIHVARFGNIGSLSV 2217
>gi|239743797 PREDICTED: similar to cell recognition molecule CASPR3
[Homo sapiens]
Length = 944
Score = 111 bits (278), Expect = 5e-24
Identities = 99/345 (28%), Positives = 159/345 (46%), Gaps = 43/345 (12%)
Query: 921 TFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIEL-VKGYIHYVF 979
+F + +SYL + + F FKTT G+ + N G DFI IEL + + F
Sbjct: 529 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI-TDFIRIELRAPTEVTFSF 587
Query: 980 DLGNGPSLMKGNSDKPVNDNQWHNVVVSRD--PGNVHTLKIDSRTVTQHSNGARNLDLKG 1037
D+GNGP + S P NDNQWH+V R+ ++ ++ + ++G L L
Sbjct: 588 DVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNS 647
Query: 1038 ELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPS 1097
+L+IGG + + GF GC+ S+ LNG DL A G VE GC G
Sbjct: 648 QLFIGGTA-----------TRQRGFLGCIRSLQLNGVALDLEERATVMPG-VEPGCAGHC 695
Query: 1098 TTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALI-----TYTW 1152
+T C N G C ++ G TCDC ++Y GP C++ + Y F G ++ YT
Sbjct: 696 ST-YGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEISAY-FATGSSMTYHFQEHYTL 753
Query: 1153 PPN----------DRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI-DQGTVG 1201
N D TR + + + F T + ++L+ V +S +YL + + + G++
Sbjct: 754 SENSSSLVSSLHRDVTLTR-EMITLSFRTTRTPSLLLYV--SSFYEEYLSVILANNGSLQ 810
Query: 1202 VIFNV----GTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1242
+ + + D T D N ++DG+ H V+ R ++V+
Sbjct: 811 IRYKLDRHQNPDAFTFDFKN--MADGQLHQVKINREEAVVMVEVN 853
Score = 75.5 bits (184), Expect = 4e-13
Identities = 83/377 (22%), Positives = 152/377 (40%), Gaps = 68/377 (18%)
Query: 488 DVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSS 547
D + + +F + +++ P + + T + F+TT +G+ + + G
Sbjct: 521 DKSFWNSASFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI----------- 569
Query: 548 AQRADYFAMEL-LDGHLYLLLDMGSGGIKLRASS-RKVNDGEWCHVDFQRDGRKGSISVN 605
D+ +EL + D+G+G ++ S ND +W HV +R+ + S+ V+
Sbjct: 570 ---TDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVD 626
Query: 606 S---RSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLF 662
+ P A G L L S+L++GG TA + G++GC+R L
Sbjct: 627 QLPQKMQPAPADGHVR-LQLNSQLFIGG----------------TATRQRGFLGCIRSLQ 669
Query: 663 IDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAP--CRNGGVCREGWNRFICDCIGTG 720
++G + DL A GV P C+ C++ CRNGG CRE CDC +
Sbjct: 670 LNGVALDLEERATVMP--GVEPGCAGH----CSTYGHLCRNGGRCREKRRGVTCDCAFSA 723
Query: 721 FLGRVCEREATVLSYDGSMYM------------KIMLPNAMHTEA----EDVSLRFMSQR 764
+ G C E + GS L +++H + E ++L F + R
Sbjct: 724 YDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSSLHRDVTLTREMITLSFRTTR 783
Query: 765 AYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETL-FAGHKLNDNEW 823
L++ +S + + G +++ LD + P+ F + D +
Sbjct: 784 TPSLLLYVSSFYEEYLSVILANNGSLQIRYKLD-------RHQNPDAFTFDFKNMADGQL 836
Query: 824 HTVRVVRRGKSLQLSVD 840
H V++ R + + V+
Sbjct: 837 HQVKINREEAVVMVEVN 853
Score = 52.0 bits (123), Expect = 5e-06
Identities = 26/77 (33%), Positives = 40/77 (51%), Gaps = 5/77 (6%)
Query: 653 GYVGCVRDLFIDGRSRDLRGLAEAQGAVGV---APFCSRETLKQCASAPCRNGGVCREGW 709
G+ GC+R + I ++ D + QGA+G S +C + C +GG C + W
Sbjct: 202 GFQGCLRLITIGDKAVD--PILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSW 259
Query: 710 NRFICDCIGTGFLGRVC 726
+ F CDC+GTG+ G C
Sbjct: 260 DTFSCDCLGTGYTGETC 276
Score = 52.0 bits (123), Expect = 5e-06
Identities = 57/240 (23%), Positives = 93/240 (38%), Gaps = 56/240 (23%)
Query: 100 TLQLDTPVADDRWHMVLLTRDARRTALAVD--GEARAAEVRSKRREMQVASDLFVGGIPP 157
T+Q TP D++WH V R+ + +L VD + +Q+ S LF+GG
Sbjct: 597 TVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGG--- 653
Query: 158 DVRLSALTLSTVKYEPPFRGLLANLKLG-------ERPPALLGSQ-GLRGATADPLCAPA 209
T + F G + +L+L ER + G + G G C+
Sbjct: 654 ----------TATRQRGFLGCIRSLQLNGVALDLEERATVMPGVEPGCAGH-----CSTY 698
Query: 210 RNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGG 269
+ C NGG C G V CDC+ + + G FCS E S F+ G
Sbjct: 699 GHLCRNGGRCREKRRG-VTCDCAFSAYDGPFCSNEI----------------SAYFATGS 741
Query: 270 AGRGGAGDVHQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH 329
+ + + ++ V++ H + + + ITL+FRT + L+L+
Sbjct: 742 SMTYHFQEHYTLSENSSSLVSSL-----------HRDVTLTREMITLSFRTTRTPSLLLY 790
Score = 51.2 bits (121), Expect = 8e-06
Identities = 26/76 (34%), Positives = 35/76 (46%), Gaps = 3/76 (3%)
Query: 1061 GFQGCLASVDLNGRLPDLIA---DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDG 1117
GFQGCL + + + D I AL ++ G + C C + G C Q WD
Sbjct: 202 GFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDT 261
Query: 1118 FTCDCTMTSYGGPVCN 1133
F+CDC T Y G C+
Sbjct: 262 FSCDCLGTGYTGETCH 277
Score = 40.0 bits (92), Expect = 0.019
Identities = 75/320 (23%), Positives = 115/320 (35%), Gaps = 74/320 (23%)
Query: 748 AMHTE-AEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPS 806
A H E DV F + + G+ M D +R+EL ++T + D VG P
Sbjct: 541 AFHGELTADVCFFFKTTVSSGVFMENLG--ITDFIRIELRA-PTEVTFSFD---VGNGPC 594
Query: 807 KGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGA--HMRLEFHN--IET 862
+ T+ + NDN+WH VR R K L VD + + Q A A H+RL+ ++
Sbjct: 595 E--VTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIG 652
Query: 863 GIMTERRFISVVPSNFIGHLSGLVFNG--------QPYMDQCKDGDITYCEL-------- 906
G T +R F+G + L NG M + G +C
Sbjct: 653 GTATRQR-------GFLGCIRSLQLNGVALDLEERATVMPGVEPGCAGHCSTYGHLCRNG 705
Query: 907 -NARFGLRAIVAD--------PVTFKSRSSYLALATLQAY----------------ASMH 941
R R + D P S+Y A + Y +S+H
Sbjct: 706 GRCREKRRGVTCDCAFSAYDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSSLH 765
Query: 942 ---------LFFQFKTTAPDGLLLFNSGNGNDFIVIELVKG---YIHYVFDLGNGPSLMK 989
+ F+TT LLL+ S +++ + L I Y D P
Sbjct: 766 RDVTLTREMITLSFRTTRTPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFT 825
Query: 990 GNSDKPVNDNQWHNVVVSRD 1009
+ K + D Q H V ++R+
Sbjct: 826 FDF-KNMADGQLHQVKINRE 844
Score = 40.0 bits (92), Expect = 0.019
Identities = 21/74 (28%), Positives = 38/74 (51%), Gaps = 2/74 (2%)
Query: 311 TDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGA-VWLVINLGSGAFEALVEPVNGKFN 369
T ++ F+T +G+ + D++ + L++ V ++G+G E V+ FN
Sbjct: 547 TADVCFFFKTTVSSGVFMENLGITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPT-PFN 605
Query: 370 DNAWHDVRVTRNLR 383
DN WH VR RN++
Sbjct: 606 DNQWHHVRAERNVK 619
Score = 34.7 bits (78), Expect = 0.82
Identities = 27/106 (25%), Positives = 51/106 (48%), Gaps = 4/106 (3%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVD-GRLRLRFTLSCAE-PATLQLDTP-VAD 109
++ S RT T +LLLY+ + ++L ++L + G L++R+ L + P D +AD
Sbjct: 775 ITLSFRTTRTPSLLLYVSSFYE-EYLSVILANNGSLQIRYKLDRHQNPDAFTFDFKNMAD 833
Query: 110 DRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGI 155
+ H V + R+ + V+ A+ + S E L +G +
Sbjct: 834 GQLHQVKINREEAVVMVEVNQSAKKQVILSSGTEFNAVKSLILGKV 879
Score = 32.7 bits (73), Expect = 3.1
Identities = 27/107 (25%), Positives = 43/107 (40%), Gaps = 13/107 (12%)
Query: 175 FRGLLANLKLGERP-PALLGSQGLRGATAD---------PLCAPARNPCANGGLCTVLAP 224
F+G L + +G++ +L QG G+ D C P+ C +GG C+ +
Sbjct: 203 FQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDRCLPSY--CEHGGECSQ-SW 259
Query: 225 GEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAG 271
CDC TG+ G+ C + AH + G G+G
Sbjct: 260 DTFSCDCLGTGYTGETCHSSLYEQSCEAHKHRGNPSGLYYIDADGSG 306
Score = 32.0 bits (71), Expect = 5.3
Identities = 25/83 (30%), Positives = 43/83 (51%), Gaps = 5/83 (6%)
Query: 1186 GLGDYLQLHIDQGT-VGVIFNVGTD--DITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1242
G+ D++++ + T V F+VG ++T+ P +D ++H VR R+ A+LQVD
Sbjct: 568 GITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPF-NDNQWHHVRAERNVKGASLQVD 626
Query: 1243 SWPVNERYPAGNFDNERLAIARQ 1265
P + PA + RL + Q
Sbjct: 627 QLP-QKMQPAPADGHVRLQLNSQ 648
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 105 bits (261), Expect = 5e-22
Identities = 108/407 (26%), Positives = 162/407 (39%), Gaps = 51/407 (12%)
Query: 76 DFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAA 135
DF+ L +V G L R+ L A L+ P+A RWH V R + +L V+G
Sbjct: 3978 DFVSLAMVGGHLEFRYELGSGL-AVLRSAEPLALGRWHRVSAERLNKDGSLRVNGGRPVL 4036
Query: 136 EVR-SKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERPPALLGS 194
K + + + + L++GG+ P V LS T + + + N K + + LGS
Sbjct: 4037 RSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEVSVNGKRLDLTYSFLGS 4096
Query: 195 QGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPME----- 249
QG+ C R PC +G C E C C GF G C EE+P +
Sbjct: 4097 QGIGQCYDSSPCE--RQPCQHGATCMPAGEYEFQCLC-RDGFKGDLCEHEENPCQLREPC 4153
Query: 250 -------GPAHLTLNSEVGSLLFSEGGAGRGGA-GDVHQPTKGKEE----FVATFKGNEF 297
G L L G + G+G G A D H G + + A F + F
Sbjct: 4154 LHGGTCQGTRCLCLPGFSGPRC--QQGSGHGIAESDWHLEGSGGNDAPGQYGAYFHDDGF 4211
Query: 298 FCYD--LSHNPIQSSTDEITLAFRTLQRNGLML-------HTGKSADYVNLSLKSGAVWL 348
+ + + + I L RT +GL+L G+ D+++L L+ G +
Sbjct: 4212 LAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVF 4271
Query: 349 VINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGIL 408
LGSG + E ND WH V R R+ + I VDG
Sbjct: 4272 RYQLGSGEARLVSED---PINDGEWHRVTALREGRRGS---------------IQVDGEE 4313
Query: 409 TTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVV 455
+G + + + YIGG+P+ A L G S+ GC+K++V
Sbjct: 4314 LVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLV 4360
Score = 83.6 bits (205), Expect = 2e-15
Identities = 73/257 (28%), Positives = 116/257 (45%), Gaps = 35/257 (13%)
Query: 480 GDLSFRCEDVAALDPVTFESPEAFVALPRWS-AKRTGSISLDFRTTEPNGLLLFSQGRRA 538
G RCE+ + + +++ALP + + ++F+ P+G+LLFS G+
Sbjct: 3915 GRSGLRCEEGVTVTTPSLSGAGSYLALPALTNTHHELRLDVEFKPLAPDGVLLFSGGK-- 3972
Query: 539 GGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGR 598
S D+ ++ ++ GHL ++GSG LR S+ + G W V +R +
Sbjct: 3973 --------SGPVEDFVSLAMVGGHLEFRYELGSGLAVLR-SAEPLALGRWHRVSAERLNK 4023
Query: 599 KGSISVNS-----RSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAG 653
GS+ VN RS+P G S+ L+L + LYLGG+ +PL P + A
Sbjct: 4024 DGSLRVNGGRPVLRSSP----GKSQGLNLHTLLYLGGV----EPSVPLSP---ATNMSAH 4072
Query: 654 YVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCR-EGWNRF 712
+ GCV ++ ++G+ DL +G S C PC++G C G F
Sbjct: 4073 FRGCVGEVSVNGKRLDLTYSFLGSQGIGQCYDSS-----PCERQPCQHGATCMPAGEYEF 4127
Query: 713 ICDCIGTGFLGRVCERE 729
C C GF G +CE E
Sbjct: 4128 QCLC-RDGFKGDLCEHE 4143
Score = 83.2 bits (204), Expect = 2e-15
Identities = 110/428 (25%), Positives = 169/428 (39%), Gaps = 93/428 (21%)
Query: 904 CELNARFGLRAIVADPVTFKSRS---SYLALATL-QAYASMHLFFQFKTTAPDGLLLFNS 959
C L R GLR VT S S SYLAL L + + L +FK APDG+LLF+
Sbjct: 3912 CHLG-RSGLRCEEGVTVTTPSLSGAGSYLALPALTNTHHELRLDVEFKPLAPDGVLLFSG 3970
Query: 960 GNG---NDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTL 1016
G DF+ + +V G++ + ++LG+G ++++ S +P+ +WH V R +
Sbjct: 3971 GKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLR--SAEPLALGRWHRVSAERLNKDGSLR 4028
Query: 1017 KIDSRTVTQHSNG-ARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRL 1075
R V + S G ++ L+L LY+GG+ ++ L F+GC+ V +NG+
Sbjct: 4029 VNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSV--PLSPATNMSAHFRGCVGEVSVNGKR 4086
Query: 1076 PDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQW---------DGF-------- 1118
DL L G G S+ C + C + C+ DGF
Sbjct: 4087 LDLTYSFL---GSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHE 4143
Query: 1119 --------------TCDCT----MTSYGGPVCNDPGTTYIFGKGGALITYTW-----PPN 1155
TC T + + GP C G G + W N
Sbjct: 4144 ENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQ-------GSGHGIAESDWHLEGSGGN 4196
Query: 1156 DRPSTR----MDRLAVGFSTHQRSAVL----------VRVDSASGL-------------- 1187
D P D + F H S L VR +ASGL
Sbjct: 4197 DAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQG 4256
Query: 1188 GDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWP-V 1246
D++ L + G + + +G+ + + + I +DG++H V R G ++QVD V
Sbjct: 4257 KDFISLGLQDGHLVFRYQLGSGEARLVSEDPI-NDGEWHRVTALREGRRGSIQVDGEELV 4315
Query: 1247 NERYPAGN 1254
+ R P N
Sbjct: 4316 SGRSPGPN 4323
Score = 82.0 bits (201), Expect = 4e-15
Identities = 68/238 (28%), Positives = 108/238 (45%), Gaps = 24/238 (10%)
Query: 494 PVTFESPEAFVALPRWS-AKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRAD 552
P ++P +F+ LP A R I + FR +G+LL++ G++ G+ ++ + ++ D
Sbjct: 3664 PYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYN-GQKRVPGSPTNLANRQPD 3722
Query: 553 YFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFL 612
+ + L+ G D GSG +R + + G + V R +GS+ V + P
Sbjct: 3723 FISFGLVGGRPEFRFDAGSGMATIRHPT-PLALGHFHTVTLLRSLTQGSLIVGDLA-PVN 3780
Query: 613 ATGDSEI--LDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDL 670
T + LDL ELYLGG P+ G + A L +G++GCVR+L I G
Sbjct: 3781 GTSQGKFQGLDLNEELYLGGYPDYGAIP--------KAGLSSGFIGCVRELRIQGEEIVF 3832
Query: 671 RGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREG-WNRFICDCIGTGFLGRVCE 727
L + P C PC+NGG C + + ++C C GF G CE
Sbjct: 3833 HDLNLTAHGISHCP--------TCRDRPCQNGGQCHDSESSSYVCVC-PAGFTGSRCE 3881
Score = 68.9 bits (167), Expect = 4e-11
Identities = 49/154 (31%), Positives = 76/154 (49%), Gaps = 27/154 (17%)
Query: 516 SISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIK 575
+I L+ RT+ +GLLL+ QG G + Q D+ ++ L DGHL +GSG +
Sbjct: 4229 TIELEVRTSTASGLLLW-QGVEVG------EAGQGKDFISLGLQDGHLVFRYQLGSGEAR 4281
Query: 576 LRASSRKVNDGEWCHVDFQRDGRKGSISVNSRS-TPFLATGDSEILDLESELYLGGLPE- 633
L S +NDGEW V R+GR+GSI V+ + G + ++ + +Y+GG P+
Sbjct: 4282 L-VSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGAPDV 4340
Query: 634 ----GGRVDLPLPPEVWTAALRAGYVGCVRDLFI 663
GGR +G GCV++L +
Sbjct: 4341 ATLTGGR-------------FSSGITGCVKNLVL 4361
Score = 61.6 bits (148), Expect = 6e-09
Identities = 113/445 (25%), Positives = 167/445 (37%), Gaps = 66/445 (14%)
Query: 927 SYLALATLQ-AYASMHLFFQFKTTAPDGLLLFN------------SGNGNDFIVIELVKG 973
S+L L T++ AY + F+ + DG+LL+N + DFI LV G
Sbjct: 3672 SFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGG 3731
Query: 974 YIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGA-RN 1032
+ FD G+G + ++ P+ +H V + R + D V S G +
Sbjct: 3732 RPEFRFDAGSGMATIR--HPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQG 3789
Query: 1033 LDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERG 1092
LDL ELY+GG + +PK S GF GC+ + + G +++ L+
Sbjct: 3790 LDLNEELYLGGYPD--YGAIPKAGLS-SGFIGCVRELRIQGE--EIVFHDLNLTAHGISH 3844
Query: 1093 CDGPSTTCTEESCANQGVCL-QQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKG-GALITY 1150
C TC + C N G C + + C C + G C + + G T
Sbjct: 3845 C----PTCRDRPCQNGGQCHDSESSSYVCVCP-AGFTGSRCEHSQALHCHPEACGPDATC 3899
Query: 1151 TWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDD 1210
P+ R T L V V S SG G YL L T +
Sbjct: 3900 VNRPDGRGYTCRCHLGRS-GLRCEEGVTVTTPSLSGAGSYLALPALTNT--------HHE 3950
Query: 1211 ITID-EPNAIVSDGKYHVVRFTRSGGNA-------TLQVDSWPVNERYPAGNFDNERLAI 1262
+ +D E + DG V+ F SGG + +L + + RY G+ LA+
Sbjct: 3951 LRLDVEFKPLAPDG---VLLF--SGGKSGPVEDFVSLAMVGGHLEFRYELGS----GLAV 4001
Query: 1263 ARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKI-GGRDQGRPFQGQVSGLYYNGLKVL 1321
R P LGR W +L N ++++ GGR R G+ GL + L L
Sbjct: 4002 LRSAEPLALGR----WHRVSAERL---NKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYL 4054
Query: 1322 ALAAES---DPNVRTEGHLR-LVGE 1342
S P H R VGE
Sbjct: 4055 GGVEPSVPLSPATNMSAHFRGCVGE 4079
Score = 57.8 bits (138), Expect = 9e-08
Identities = 39/142 (27%), Positives = 71/142 (50%), Gaps = 18/142 (12%)
Query: 945 QFKTTAPDGLLLFN------SGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVND 998
+ +T+ GLLL+ +G G DFI + L G++ + + LG+G + + S+ P+ND
Sbjct: 4233 EVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLV--SEDPIND 4290
Query: 999 NQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARN--LDLKGELYIGGLSKNMFSNLPKLV 1056
+WH V R+ G ++++D + + N ++ KG +YIGG ++ L
Sbjct: 4291 GEWHRVTALRE-GRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGA-----PDVATLT 4344
Query: 1057 ASR--DGFQGCLASVDLNGRLP 1076
R G GC+ ++ L+ P
Sbjct: 4345 GGRFSSGITGCVKNLVLHSARP 4366
Score = 56.6 bits (135), Expect = 2e-07
Identities = 99/412 (24%), Positives = 156/412 (37%), Gaps = 50/412 (12%)
Query: 76 DFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARA- 134
DF+ LV GR RF AT++ TP+A +H V L R + +L V A
Sbjct: 3722 DFISFGLVGGRPEFRFDAGSGM-ATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVN 3780
Query: 135 AEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKL-GERPPALLG 193
+ K + + + +L++GG P + LS+ F G + L++ GE
Sbjct: 3781 GTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSS-----GFIGCVRELRIQGEEIVFHDL 3835
Query: 194 SQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEE----HPME 249
+ G + P C PC NGG C C C GF G C + HP
Sbjct: 3836 NLTAHGISHCPTCRD--RPCQNGGQCHDSESSSYVCVCP-AGFTGSRCEHSQALHCHPEA 3892
Query: 250 -GPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVATFKGNEFFCYDLSHNPIQ 308
GP +N G GR G + +G + G + L+ +
Sbjct: 3893 CGPDATCVNRPDGRGYTCRCHLGRSGL----RCEEGVTVTTPSLSGAGSY---LALPALT 3945
Query: 309 SSTDEITL--AFRTLQRNGLMLHTGKSA----DYVNLSLKSGAVWLVINLGSG-AFEALV 361
++ E+ L F+ L +G++L +G + D+V+L++ G + LGSG A
Sbjct: 3946 NTHHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSA 4005
Query: 362 EPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTML 421
EP+ WH V R L+ ++ V+G + L
Sbjct: 4006 EPL----ALGRWHRVSAER---------------LNKDGSLRVNGGRPVLRSSPGKSQGL 4046
Query: 422 GSDDFFYIGG-SPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEG 472
Y+GG P+ P + +S +F GC+ +V L S L +G
Sbjct: 4047 NLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEVSVNGKRLDLTYSFLGSQG 4098
Score = 37.4 bits (85), Expect = 0.13
Identities = 33/155 (21%), Positives = 64/155 (41%), Gaps = 31/155 (20%)
Query: 313 EITLAFRTLQRNGLMLHTG-------------KSADYVNLSLKSGAVWLVINLGSGAFEA 359
EI + FR +G++L+ G + D+++ L G + GSG
Sbjct: 3687 EIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRPEFRFDAGSG-MAT 3745
Query: 360 LVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYT 419
+ P +H V + R+L Q + I V + G +Q +
Sbjct: 3746 IRHPTPLALGH--FHTVTLLRSLTQGSLI---------------VGDLAPVNGTSQGKFQ 3788
Query: 420 MLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDV 454
L ++ Y+GG P+ +P + +S+ F+GC++++
Sbjct: 3789 GLDLNEELYLGGYPDYGAIPKAGLSSGFIGCVREL 3823
>gi|33469931 EGF-like, fibronectin type III and laminin G domains
isoform 2 [Homo sapiens]
Length = 775
Score = 99.8 bits (247), Expect = 2e-20
Identities = 132/603 (21%), Positives = 240/603 (39%), Gaps = 111/603 (18%)
Query: 292 FKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKS----ADYVNLSLKSGAVW 347
F G+ + ++ N Q+ +ITL FR +GL+L+ G++ D+++L++ ++
Sbjct: 157 FFGHSYVTFEPLKNSYQAF--QITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQ 214
Query: 348 LVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGI 407
N G+G + E K WH V + R+ +N L + ++
Sbjct: 215 FRFNCGTGVAIIVSET---KIKLGGWHTVMLYRD----------GLNGL-----LQLNNG 256
Query: 408 LTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNN-FMGCLKDVVYKNNDFKLELS 466
TG +Q Y+ + Y+GG+P+ L + +N F GC++ + +
Sbjct: 257 TPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPW 316
Query: 467 RLAK---------------------EGDPKMKLQGD-------LSFR---CEDVAALDPV 495
L K G ++ D L F+ CED L
Sbjct: 317 PLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIP 376
Query: 496 TF-ESPEAFVALPRWSAKRTGSIS-----LDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQ 549
F ES ++ A P W + +S + FR +G+LL+S GS
Sbjct: 377 QFRESLRSYAATP-WPLEPQHYLSFMEFEITFRPDSGDGVLLYSYD------TGSK---- 425
Query: 550 RADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRS- 608
D+ ++ L GH+ D GSG LR S + G W + R + G + V+ +
Sbjct: 426 --DFLSINLAGGHVEFRFDCGSGTGVLR-SEDPLTLGNWHELRVSRTAKNGILQVDKQKI 482
Query: 609 TPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSR 668
+A G + +++++GG+P V + + + G ++ + ++ R+
Sbjct: 483 VEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK-------NSGVLKPFSGSIQKIILNDRTI 535
Query: 669 DLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCER 728
++ + V V C APC +GG CR + CDC GF G C++
Sbjct: 536 HVKH--DFTSGVNV-----ENAAHPCVRAPCAHGGSCRPRKEGYDCDC-PLGFEGLHCQK 587
Query: 729 EAT----VLSYDGSMYMKIMLPNAMHTEA---EDVSLRFMSQRAYGLMM---ATTSRESA 778
+ + G Y+ P+ + + +V +RF + GL++ + R ++
Sbjct: 588 AIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNS 647
Query: 779 DTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLS 838
D + L L G + + NL G ++ ND WH V+ VR G+S +++
Sbjct: 648 DFISLGLRDGALVFSYNL---------GSGVASIMVNGSFNDGRWHRVKAVRDGQSGKIT 698
Query: 839 VDN 841
VD+
Sbjct: 699 VDD 701
Score = 98.2 bits (243), Expect = 6e-20
Identities = 107/437 (24%), Positives = 170/437 (38%), Gaps = 88/437 (20%)
Query: 52 ELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDR 111
E + R ++ +LLY D G DFL + L G + RF + L+ + P+
Sbjct: 402 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCG-SGTGVLRSEDPLTLGN 460
Query: 112 WHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVA--SDLFVGGIP--PDVRLSALTLS 167
WH + ++R A+ L VD + + E ++ Q+ +D+F+GG+P DV+ ++ L
Sbjct: 461 WHELRVSRTAKNGILQVD-KQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLK 519
Query: 168 TVKYEPPFRGLLANLKLGERPPALLG--SQGLRGATADPLCAPARNPCANGGLCTVLAPG 225
PF G + + L +R + + G+ A C R PCA+GG C G
Sbjct: 520 ------PFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPC--VRAPCAHGGSCRPRKEG 571
Query: 226 EVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGK 285
CDC GF G C Q +
Sbjct: 572 -YDCDCP-LGFEGLHC--------------------------------------QKAIIE 591
Query: 286 EEFVATFKGNEFFCYDLSHNP-----IQSSTDEITLAFRTLQRNGLMLHTGKS-----AD 335
+ F G + YD NP + S + + F+T ++GL+L G S +D
Sbjct: 592 AIEIPQFIGRSYLTYD---NPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSD 648
Query: 336 YVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNK 395
+++L L+ GA+ NLGSG + VNG FND WH V+ R+ +
Sbjct: 649 FISLGLRDGALVFSYNLGSGVASIM---VNGSFNDGRWHRVKAVRDGQSG---------- 695
Query: 396 LHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVV 455
I+VD TG + L + Y+GG A +GC+
Sbjct: 696 -----KITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFT 750
Query: 456 YKNNDFKLELSRLAKEG 472
+ D+ + L A +G
Sbjct: 751 L-STDYHISLVEDAVDG 766
Score = 97.4 bits (241), Expect = 1e-19
Identities = 145/631 (22%), Positives = 247/631 (39%), Gaps = 84/631 (13%)
Query: 675 EAQGAVGVAPFCSRETLKQCASAPCRNGGVCREG--WNRFICDC-IGTGFLGRVCEREAT 731
+ +G GVA SR C C C W C C +G G G C +
Sbjct: 95 QRKGKNGVA-IMSRLFDMPCDETLCSADSFCVNDYTWGGSRCQCTLGKG--GESCSEDIV 151
Query: 732 VL--SYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQ 789
+ + G Y+ P +A ++L F ++ GL++ E G
Sbjct: 152 IQYPQFFGHSYVTFE-PLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGR-------GDF 203
Query: 790 MKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVT-VEGQM 848
M L + L+ G + + K+ WHTV + R G + L ++N T V GQ
Sbjct: 204 MSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQS 263
Query: 849 AGAHMRLEFHN--IETGIMTERRFISVVPSN--FIGHLSGLVFNGQ-------PYMDQCK 897
G + ++ F G + + +N F G + L NG+ P
Sbjct: 264 QGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALS 323
Query: 898 DGDITYC------ELNARFG--LRAIVAD------PVTFKSRSSYLALA--------TLQ 935
D+ C E + G AI AD P+ FK R A +L+
Sbjct: 324 GADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLR 383
Query: 936 AYAS-------------MHLFFQFKTTAPDGLLLFNSGNGN-DFIVIELVKGYIHYVFDL 981
+YA+ M F+ + DG+LL++ G+ DF+ I L G++ + FD
Sbjct: 384 SYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDC 443
Query: 982 GNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQH--SNGARNLDLKGEL 1039
G+G +++ S+ P+ WH + VSR N L++D + + + G + ++
Sbjct: 444 GSGTGVLR--SEDPLTLGNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDI 500
Query: 1040 YIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTT 1099
+IGG+ + ++ K F G + + LN R + D + + +
Sbjct: 501 FIGGVPN--YDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVN-----VENAAHP 553
Query: 1100 CTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGK---GGALITYTWPP-N 1155
C CA+ G C + +G+ CDC + + G C I G + +TY P
Sbjct: 554 CVRAPCAHGGSCRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDIL 612
Query: 1156 DRPSTRMDRLAVGFSTHQRSAVLV-RVDS-ASGLGDYLQLHIDQGTVGVIFNVGTDDITI 1213
R S + + F T + +L+ R DS D++ L + G + +N+G+ +I
Sbjct: 613 KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI 672
Query: 1214 DEPNAIVSDGKYHVVRFTRSGGNATLQVDSW 1244
N +DG++H V+ R G + + VD +
Sbjct: 673 -MVNGSFNDGRWHRVKAVRDGQSGKITVDDY 702
Score = 94.4 bits (233), Expect = 9e-19
Identities = 90/343 (26%), Positives = 151/343 (44%), Gaps = 26/343 (7%)
Query: 927 SYLALATLQ-AYASMHLFFQFKTTAPDGLLLF---NSGNGNDFIVIELVKGYIHYVFDLG 982
SY+ L+ +Y + + +F+ A DGLLL+ N DF+ + +++ + + F+ G
Sbjct: 161 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCG 220
Query: 983 NGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARN-LDLKGELYI 1041
G +++ S+ + WH V++ RD N + VT S G + + + LY+
Sbjct: 221 TGVAIIV--SETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYL 278
Query: 1042 GGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCD---GPST 1098
GG + L + + GFQGC+ S+ +NGR D+ L G+ G D S
Sbjct: 279 GGAPSAYW--LVRATGTNRGFQGCVQSLAVNGRRIDMRPWPL---GKALSGADVGECSSG 333
Query: 1099 TCTEESCANQGVCLQ-QWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYT---WPP 1154
C E SC + G C + D + C C + + G C D T I +L +Y WP
Sbjct: 334 ICDEASCIHGGTCTAIKADSYICLCPL-GFKGRHCEDAFTLTIPQFRESLRSYAATPWPL 392
Query: 1155 NDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNV--GTDDIT 1212
+ + F VL+ +G D+L +++ G V F+ GT +
Sbjct: 393 EPQHYLSFMEFEITFRPDSGDGVLL-YSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR 451
Query: 1213 IDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNF 1255
++P + G +H +R +R+ N LQVD + E G F
Sbjct: 452 SEDPLTL---GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGF 491
Score = 90.9 bits (224), Expect = 1e-17
Identities = 146/630 (23%), Positives = 249/630 (39%), Gaps = 124/630 (19%)
Query: 52 ELSFSLRTNATRALLLYLDDG--GDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVAD 109
+++ R A LLLY + G DF+ L ++ L+ RF A + +T +
Sbjct: 176 QITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGV-AIIVSETKIKL 234
Query: 110 DRWHMVLLTRDARRTALAVD-GEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLST 168
WH V+L RD L ++ G + + + ++ + L++GG P L T +
Sbjct: 235 GGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTN 294
Query: 169 VKYEPPFRGLLANLKLGERPPALLGSQGLRGAT----ADPLCAPARNPCANGGLCTVLAP 224
++ + L N + + P LG + L GA + +C A C +GG CT +
Sbjct: 295 RGFQGCVQSLAVNGRRIDMRPWPLG-KALSGADVGECSSGICDEAS--CIHGGTCTAIKA 351
Query: 225 GEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKG 284
C C GF G+ C + TL + Q +
Sbjct: 352 DSYICLCP-LGFKGRHCEDA---------FTLT--------------------IPQFRES 381
Query: 285 KEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH---TGKSADYVNLSL 341
+ AT E Y S E + FR +G++L+ TG S D+++++L
Sbjct: 382 LRSYAATPWPLEPQHY--------LSFMEFEITFRPDSGDGVLLYSYDTG-SKDFLSINL 432
Query: 342 KSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVT 401
G V + GSG E N WH++RV+R + GI
Sbjct: 433 AGGHVEFRFDCGSGTGVLRSEDPLTLGN---WHELRVSRTAKN--GI------------- 474
Query: 402 ISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADL-PGSPVSNNFMGCLKDV------ 454
+ VD G + +T + + +IGG PN D+ S V F G ++ +
Sbjct: 475 LQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRT 534
Query: 455 VYKNNDFKLELS-------------------RLAKEG---DPKMKLQGDLSFRCEDVAAL 492
++ +DF ++ R KEG D + +G L + + A+
Sbjct: 535 IHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEG-LHCQKAIIEAI 593
Query: 493 D--------PVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGS 544
+ +T+++P+ L R S R+ ++ + F+TT +GLLL+ G
Sbjct: 594 EIPQFIGRSYLTYDNPD---ILKRVSGSRS-NVFMRFKTTAKDGLLLW---------RGD 640
Query: 545 HSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISV 604
+D+ ++ L DG L ++GSG + + NDG W V RDG+ G I+V
Sbjct: 641 SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNG-SFNDGRWHRVKAVRDGQSGKITV 699
Query: 605 NS-RSTPFLATGDSEILDLESELYLGGLPE 633
+ + + G L++ LY+GG+ E
Sbjct: 700 DDYGARTGKSPGMMRQLNINGALYVGGMKE 729
Score = 85.5 bits (210), Expect = 4e-16
Identities = 100/375 (26%), Positives = 153/375 (40%), Gaps = 55/375 (14%)
Query: 495 VTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYF 554
VTFE P ++ + I+L+FR +GLLL+ G H R D+
Sbjct: 163 VTFE--------PLKNSYQAFQITLEFRAEAEDGLLLYC-------GENEHG---RGDFM 204
Query: 555 AMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFL-- 612
++ ++ L + G+G + + S K+ G W V RDG G + +N+ TP
Sbjct: 205 SLAIIRRSLQFRFNCGTG-VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNN-GTPVTGQ 262
Query: 613 ATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLR- 671
+ G + + LYLGG P + V G+ GCV+ L ++GR D+R
Sbjct: 263 SQGQYSKITFRTPLYLGGAPSAYWL-------VRATGTNRGFQGCVQSLAVNGRRIDMRP 315
Query: 672 -GLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCRE-GWNRFICDCIGTGFLGRVCER- 728
L +A V CS C A C +GG C + +IC C GF GR CE
Sbjct: 316 WPLGKALSGADVGE-CSSGI---CDEASCIHGGTCTAIKADSYICLC-PLGFKGRHCEDA 370
Query: 729 -EATVLSYDGSMYMKIMLPNAM----HTEAEDVSLRFMSQRAYGLMMATTSRESADTLRL 783
T+ + S+ P + + + + F G+++ + S D L +
Sbjct: 371 FTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSI 430
Query: 784 ELDGGQMKLTVNLDC-LRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD-N 841
L GG ++ DC G S+ P TL WH +RV R K+ L VD
Sbjct: 431 NLAGGHVEF--RFDCGSGTGVLRSEDPLTL--------GNWHELRVSRTAKNGILQVDKQ 480
Query: 842 VTVEGQMAGAHMRLE 856
VEG G +++
Sbjct: 481 KIVEGMAEGGFTQIK 495
Score = 58.5 bits (140), Expect = 5e-08
Identities = 38/111 (34%), Positives = 59/111 (53%), Gaps = 7/111 (6%)
Query: 941 HLFFQFKTTAPDGLLLFNSGN----GNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPV 996
++F +FKTTA DGLLL+ + +DFI + L G + + ++LG+G + + N
Sbjct: 621 NVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS--F 678
Query: 997 NDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGA-RNLDLKGELYIGGLSK 1046
ND +WH V RD + D T S G R L++ G LY+GG+ +
Sbjct: 679 NDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKE 729
Score = 45.1 bits (105), Expect = 6e-04
Identities = 52/224 (23%), Positives = 84/224 (37%), Gaps = 28/224 (12%)
Query: 1100 CTEESCANQGVCLQQ--WDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDR 1157
C E C+ C+ W G C CT+ G D Y G + +T+ N
Sbjct: 113 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKN-- 170
Query: 1158 PSTRMDRLAVGFSTHQRSAVLVRV-DSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEP 1216
S + ++ + F +L+ ++ G GD++ L I + ++ FN GT + I
Sbjct: 171 -SYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGT-GVAIIVS 228
Query: 1217 NAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVD 1276
+ G +H V R G N LQ +N P + + R P LG
Sbjct: 229 ETKIKLGGWHTVMLYRDGLNGLLQ-----LNNGTPVTGQSQGQYSKITFRTPLYLGGAPS 283
Query: 1277 EWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKV 1320
+ L ++ G ++G FQG V L NG ++
Sbjct: 284 AYWL--------------VRATGTNRG--FQGCVQSLAVNGRRI 311
Score = 43.9 bits (102), Expect = 0.001
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 5/113 (4%)
Query: 47 AASSGELSFSLRTNATRALLLYLDDGG---DCDFLELLLVDGRLRLRFTLSCAEPATLQL 103
+ S + +T A LLL+ D + DF+ L L DG L + L A++ +
Sbjct: 616 SGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGV-ASIMV 674
Query: 104 DTPVADDRWHMVLLTRDARRTALAVDG-EARAAEVRSKRREMQVASDLFVGGI 155
+ D RWH V RD + + VD AR + R++ + L+VGG+
Sbjct: 675 NGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGM 727
>gi|33469929 EGF-like, fibronectin type III and laminin G domains
isoform 1 [Homo sapiens]
Length = 1009
Score = 99.8 bits (247), Expect = 2e-20
Identities = 132/603 (21%), Positives = 240/603 (39%), Gaps = 111/603 (18%)
Query: 292 FKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKS----ADYVNLSLKSGAVW 347
F G+ + ++ N Q+ +ITL FR +GL+L+ G++ D+++L++ ++
Sbjct: 391 FFGHSYVTFEPLKNSYQAF--QITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQ 448
Query: 348 LVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGI 407
N G+G + E K WH V + R+ +N L + ++
Sbjct: 449 FRFNCGTGVAIIVSET---KIKLGGWHTVMLYRD----------GLNGL-----LQLNNG 490
Query: 408 LTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNN-FMGCLKDVVYKNNDFKLELS 466
TG +Q Y+ + Y+GG+P+ L + +N F GC++ + +
Sbjct: 491 TPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPW 550
Query: 467 RLAK---------------------EGDPKMKLQGD-------LSFR---CEDVAALDPV 495
L K G ++ D L F+ CED L
Sbjct: 551 PLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIP 610
Query: 496 TF-ESPEAFVALPRWSAKRTGSIS-----LDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQ 549
F ES ++ A P W + +S + FR +G+LL+S GS
Sbjct: 611 QFRESLRSYAATP-WPLEPQHYLSFMEFEITFRPDSGDGVLLYSYD------TGSK---- 659
Query: 550 RADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRS- 608
D+ ++ L GH+ D GSG LR S + G W + R + G + V+ +
Sbjct: 660 --DFLSINLAGGHVEFRFDCGSGTGVLR-SEDPLTLGNWHELRVSRTAKNGILQVDKQKI 716
Query: 609 TPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSR 668
+A G + +++++GG+P V + + + G ++ + ++ R+
Sbjct: 717 VEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK-------NSGVLKPFSGSIQKIILNDRTI 769
Query: 669 DLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCER 728
++ + V V C APC +GG CR + CDC GF G C++
Sbjct: 770 HVKH--DFTSGVNV-----ENAAHPCVRAPCAHGGSCRPRKEGYDCDC-PLGFEGLHCQK 821
Query: 729 EAT----VLSYDGSMYMKIMLPNAMHTEA---EDVSLRFMSQRAYGLMM---ATTSRESA 778
+ + G Y+ P+ + + +V +RF + GL++ + R ++
Sbjct: 822 AIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNS 881
Query: 779 DTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLS 838
D + L L G + + NL G ++ ND WH V+ VR G+S +++
Sbjct: 882 DFISLGLRDGALVFSYNL---------GSGVASIMVNGSFNDGRWHRVKAVRDGQSGKIT 932
Query: 839 VDN 841
VD+
Sbjct: 933 VDD 935
Score = 98.2 bits (243), Expect = 6e-20
Identities = 107/437 (24%), Positives = 170/437 (38%), Gaps = 88/437 (20%)
Query: 52 ELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDR 111
E + R ++ +LLY D G DFL + L G + RF + L+ + P+
Sbjct: 636 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCG-SGTGVLRSEDPLTLGN 694
Query: 112 WHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVA--SDLFVGGIP--PDVRLSALTLS 167
WH + ++R A+ L VD + + E ++ Q+ +D+F+GG+P DV+ ++ L
Sbjct: 695 WHELRVSRTAKNGILQVD-KQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLK 753
Query: 168 TVKYEPPFRGLLANLKLGERPPALLG--SQGLRGATADPLCAPARNPCANGGLCTVLAPG 225
PF G + + L +R + + G+ A C R PCA+GG C G
Sbjct: 754 ------PFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPC--VRAPCAHGGSCRPRKEG 805
Query: 226 EVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGK 285
CDC GF G C Q +
Sbjct: 806 -YDCDCP-LGFEGLHC--------------------------------------QKAIIE 825
Query: 286 EEFVATFKGNEFFCYDLSHNP-----IQSSTDEITLAFRTLQRNGLMLHTGKS-----AD 335
+ F G + YD NP + S + + F+T ++GL+L G S +D
Sbjct: 826 AIEIPQFIGRSYLTYD---NPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSD 882
Query: 336 YVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNK 395
+++L L+ GA+ NLGSG + VNG FND WH V+ R+ +
Sbjct: 883 FISLGLRDGALVFSYNLGSGVASIM---VNGSFNDGRWHRVKAVRDGQSG---------- 929
Query: 396 LHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVV 455
I+VD TG + L + Y+GG A +GC+
Sbjct: 930 -----KITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFT 984
Query: 456 YKNNDFKLELSRLAKEG 472
+ D+ + L A +G
Sbjct: 985 L-STDYHISLVEDAVDG 1000
Score = 97.4 bits (241), Expect = 1e-19
Identities = 145/631 (22%), Positives = 247/631 (39%), Gaps = 84/631 (13%)
Query: 675 EAQGAVGVAPFCSRETLKQCASAPCRNGGVCREG--WNRFICDC-IGTGFLGRVCEREAT 731
+ +G GVA SR C C C W C C +G G G C +
Sbjct: 329 QRKGKNGVA-IMSRLFDMPCDETLCSADSFCVNDYTWGGSRCQCTLGKG--GESCSEDIV 385
Query: 732 VL--SYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQ 789
+ + G Y+ P +A ++L F ++ GL++ E G
Sbjct: 386 IQYPQFFGHSYVTFE-PLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGR-------GDF 437
Query: 790 MKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVT-VEGQM 848
M L + L+ G + + K+ WHTV + R G + L ++N T V GQ
Sbjct: 438 MSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQS 497
Query: 849 AGAHMRLEFHN--IETGIMTERRFISVVPSN--FIGHLSGLVFNGQ-------PYMDQCK 897
G + ++ F G + + +N F G + L NG+ P
Sbjct: 498 QGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALS 557
Query: 898 DGDITYC------ELNARFG--LRAIVAD------PVTFKSRSSYLALA--------TLQ 935
D+ C E + G AI AD P+ FK R A +L+
Sbjct: 558 GADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLR 617
Query: 936 AYAS-------------MHLFFQFKTTAPDGLLLFNSGNGN-DFIVIELVKGYIHYVFDL 981
+YA+ M F+ + DG+LL++ G+ DF+ I L G++ + FD
Sbjct: 618 SYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDC 677
Query: 982 GNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQH--SNGARNLDLKGEL 1039
G+G +++ S+ P+ WH + VSR N L++D + + + G + ++
Sbjct: 678 GSGTGVLR--SEDPLTLGNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDI 734
Query: 1040 YIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTT 1099
+IGG+ + ++ K F G + + LN R + D + + +
Sbjct: 735 FIGGVPN--YDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVN-----VENAAHP 787
Query: 1100 CTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGK---GGALITYTWPP-N 1155
C CA+ G C + +G+ CDC + + G C I G + +TY P
Sbjct: 788 CVRAPCAHGGSCRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDIL 846
Query: 1156 DRPSTRMDRLAVGFSTHQRSAVLV-RVDS-ASGLGDYLQLHIDQGTVGVIFNVGTDDITI 1213
R S + + F T + +L+ R DS D++ L + G + +N+G+ +I
Sbjct: 847 KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI 906
Query: 1214 DEPNAIVSDGKYHVVRFTRSGGNATLQVDSW 1244
N +DG++H V+ R G + + VD +
Sbjct: 907 -MVNGSFNDGRWHRVKAVRDGQSGKITVDDY 936
Score = 94.4 bits (233), Expect = 9e-19
Identities = 90/343 (26%), Positives = 151/343 (44%), Gaps = 26/343 (7%)
Query: 927 SYLALATLQ-AYASMHLFFQFKTTAPDGLLLF---NSGNGNDFIVIELVKGYIHYVFDLG 982
SY+ L+ +Y + + +F+ A DGLLL+ N DF+ + +++ + + F+ G
Sbjct: 395 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCG 454
Query: 983 NGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARN-LDLKGELYI 1041
G +++ S+ + WH V++ RD N + VT S G + + + LY+
Sbjct: 455 TGVAIIV--SETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYL 512
Query: 1042 GGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCD---GPST 1098
GG + L + + GFQGC+ S+ +NGR D+ L G+ G D S
Sbjct: 513 GGAPSAYW--LVRATGTNRGFQGCVQSLAVNGRRIDMRPWPL---GKALSGADVGECSSG 567
Query: 1099 TCTEESCANQGVCLQ-QWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYT---WPP 1154
C E SC + G C + D + C C + + G C D T I +L +Y WP
Sbjct: 568 ICDEASCIHGGTCTAIKADSYICLCPL-GFKGRHCEDAFTLTIPQFRESLRSYAATPWPL 626
Query: 1155 NDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNV--GTDDIT 1212
+ + F VL+ +G D+L +++ G V F+ GT +
Sbjct: 627 EPQHYLSFMEFEITFRPDSGDGVLL-YSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR 685
Query: 1213 IDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNF 1255
++P + G +H +R +R+ N LQVD + E G F
Sbjct: 686 SEDPLTL---GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGF 725
Score = 90.9 bits (224), Expect = 1e-17
Identities = 146/630 (23%), Positives = 249/630 (39%), Gaps = 124/630 (19%)
Query: 52 ELSFSLRTNATRALLLYLDDG--GDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVAD 109
+++ R A LLLY + G DF+ L ++ L+ RF A + +T +
Sbjct: 410 QITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGV-AIIVSETKIKL 468
Query: 110 DRWHMVLLTRDARRTALAVD-GEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLST 168
WH V+L RD L ++ G + + + ++ + L++GG P L T +
Sbjct: 469 GGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTN 528
Query: 169 VKYEPPFRGLLANLKLGERPPALLGSQGLRGAT----ADPLCAPARNPCANGGLCTVLAP 224
++ + L N + + P LG + L GA + +C A C +GG CT +
Sbjct: 529 RGFQGCVQSLAVNGRRIDMRPWPLG-KALSGADVGECSSGICDEAS--CIHGGTCTAIKA 585
Query: 225 GEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKG 284
C C GF G+ C + TL + Q +
Sbjct: 586 DSYICLCP-LGFKGRHCEDA---------FTLT--------------------IPQFRES 615
Query: 285 KEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH---TGKSADYVNLSL 341
+ AT E Y S E + FR +G++L+ TG S D+++++L
Sbjct: 616 LRSYAATPWPLEPQHY--------LSFMEFEITFRPDSGDGVLLYSYDTG-SKDFLSINL 666
Query: 342 KSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVT 401
G V + GSG E N WH++RV+R + GI
Sbjct: 667 AGGHVEFRFDCGSGTGVLRSEDPLTLGN---WHELRVSRTAKN--GI------------- 708
Query: 402 ISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADL-PGSPVSNNFMGCLKDV------ 454
+ VD G + +T + + +IGG PN D+ S V F G ++ +
Sbjct: 709 LQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRT 768
Query: 455 VYKNNDFKLELS-------------------RLAKEG---DPKMKLQGDLSFRCEDVAAL 492
++ +DF ++ R KEG D + +G L + + A+
Sbjct: 769 IHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEG-LHCQKAIIEAI 827
Query: 493 D--------PVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGS 544
+ +T+++P+ L R S R+ ++ + F+TT +GLLL+ G
Sbjct: 828 EIPQFIGRSYLTYDNPD---ILKRVSGSRS-NVFMRFKTTAKDGLLLW---------RGD 874
Query: 545 HSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISV 604
+D+ ++ L DG L ++GSG + + NDG W V RDG+ G I+V
Sbjct: 875 SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNG-SFNDGRWHRVKAVRDGQSGKITV 933
Query: 605 NS-RSTPFLATGDSEILDLESELYLGGLPE 633
+ + + G L++ LY+GG+ E
Sbjct: 934 DDYGARTGKSPGMMRQLNINGALYVGGMKE 963
Score = 85.5 bits (210), Expect = 4e-16
Identities = 100/375 (26%), Positives = 153/375 (40%), Gaps = 55/375 (14%)
Query: 495 VTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYF 554
VTFE P ++ + I+L+FR +GLLL+ G H R D+
Sbjct: 397 VTFE--------PLKNSYQAFQITLEFRAEAEDGLLLYC-------GENEHG---RGDFM 438
Query: 555 AMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFL-- 612
++ ++ L + G+G + + S K+ G W V RDG G + +N+ TP
Sbjct: 439 SLAIIRRSLQFRFNCGTG-VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNN-GTPVTGQ 496
Query: 613 ATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLR- 671
+ G + + LYLGG P + V G+ GCV+ L ++GR D+R
Sbjct: 497 SQGQYSKITFRTPLYLGGAPSAYWL-------VRATGTNRGFQGCVQSLAVNGRRIDMRP 549
Query: 672 -GLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCRE-GWNRFICDCIGTGFLGRVCER- 728
L +A V CS C A C +GG C + +IC C GF GR CE
Sbjct: 550 WPLGKALSGADVGE-CSSGI---CDEASCIHGGTCTAIKADSYICLC-PLGFKGRHCEDA 604
Query: 729 -EATVLSYDGSMYMKIMLPNAM----HTEAEDVSLRFMSQRAYGLMMATTSRESADTLRL 783
T+ + S+ P + + + + F G+++ + S D L +
Sbjct: 605 FTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSI 664
Query: 784 ELDGGQMKLTVNLDC-LRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD-N 841
L GG ++ DC G S+ P TL WH +RV R K+ L VD
Sbjct: 665 NLAGGHVEF--RFDCGSGTGVLRSEDPLTL--------GNWHELRVSRTAKNGILQVDKQ 714
Query: 842 VTVEGQMAGAHMRLE 856
VEG G +++
Sbjct: 715 KIVEGMAEGGFTQIK 729
Score = 58.5 bits (140), Expect = 5e-08
Identities = 38/111 (34%), Positives = 59/111 (53%), Gaps = 7/111 (6%)
Query: 941 HLFFQFKTTAPDGLLLFNSGN----GNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPV 996
++F +FKTTA DGLLL+ + +DFI + L G + + ++LG+G + + N
Sbjct: 855 NVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS--F 912
Query: 997 NDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGA-RNLDLKGELYIGGLSK 1046
ND +WH V RD + D T S G R L++ G LY+GG+ +
Sbjct: 913 NDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKE 963
Score = 45.1 bits (105), Expect = 6e-04
Identities = 52/224 (23%), Positives = 84/224 (37%), Gaps = 28/224 (12%)
Query: 1100 CTEESCANQGVCLQQ--WDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDR 1157
C E C+ C+ W G C CT+ G D Y G + +T+ N
Sbjct: 347 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKN-- 404
Query: 1158 PSTRMDRLAVGFSTHQRSAVLVRV-DSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEP 1216
S + ++ + F +L+ ++ G GD++ L I + ++ FN GT + I
Sbjct: 405 -SYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGT-GVAIIVS 462
Query: 1217 NAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVD 1276
+ G +H V R G N LQ +N P + + R P LG
Sbjct: 463 ETKIKLGGWHTVMLYRDGLNGLLQ-----LNNGTPVTGQSQGQYSKITFRTPLYLGGAPS 517
Query: 1277 EWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKV 1320
+ L ++ G ++G FQG V L NG ++
Sbjct: 518 AYWL--------------VRATGTNRG--FQGCVQSLAVNGRRI 545
Score = 43.9 bits (102), Expect = 0.001
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 5/113 (4%)
Query: 47 AASSGELSFSLRTNATRALLLYLDDGG---DCDFLELLLVDGRLRLRFTLSCAEPATLQL 103
+ S + +T A LLL+ D + DF+ L L DG L + L A++ +
Sbjct: 850 SGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGV-ASIMV 908
Query: 104 DTPVADDRWHMVLLTRDARRTALAVDG-EARAAEVRSKRREMQVASDLFVGGI 155
+ D RWH V RD + + VD AR + R++ + L+VGG+
Sbjct: 909 NGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGM 961
>gi|33469935 EGF-like, fibronectin type III and laminin G domains
isoform 3 [Homo sapiens]
Length = 375
Score = 98.2 bits (243), Expect = 6e-20
Identities = 107/437 (24%), Positives = 170/437 (38%), Gaps = 88/437 (20%)
Query: 52 ELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDR 111
E + R ++ +LLY D G DFL + L G + RF + L+ + P+
Sbjct: 2 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCG-SGTGVLRSEDPLTLGN 60
Query: 112 WHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVA--SDLFVGGIP--PDVRLSALTLS 167
WH + ++R A+ L VD + + E ++ Q+ +D+F+GG+P DV+ ++ L
Sbjct: 61 WHELRVSRTAKNGILQVD-KQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLK 119
Query: 168 TVKYEPPFRGLLANLKLGERPPALLG--SQGLRGATADPLCAPARNPCANGGLCTVLAPG 225
PF G + + L +R + + G+ A C R PCA+GG C G
Sbjct: 120 ------PFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPC--VRAPCAHGGSCRPRKEG 171
Query: 226 EVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGK 285
CDC GF G C Q +
Sbjct: 172 -YDCDCP-LGFEGLHC--------------------------------------QKAIIE 191
Query: 286 EEFVATFKGNEFFCYDLSHNP-----IQSSTDEITLAFRTLQRNGLMLHTGKS-----AD 335
+ F G + YD NP + S + + F+T ++GL+L G S +D
Sbjct: 192 AIEIPQFIGRSYLTYD---NPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSD 248
Query: 336 YVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNK 395
+++L L+ GA+ NLGSG + VNG FND WH V+ R+ +
Sbjct: 249 FISLGLRDGALVFSYNLGSGVASIM---VNGSFNDGRWHRVKAVRDGQSG---------- 295
Query: 396 LHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVV 455
I+VD TG + L + Y+GG A +GC+
Sbjct: 296 -----KITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFT 350
Query: 456 YKNNDFKLELSRLAKEG 472
+ D+ + L A +G
Sbjct: 351 L-STDYHISLVEDAVDG 366
Score = 84.0 bits (206), Expect = 1e-15
Identities = 76/314 (24%), Positives = 140/314 (44%), Gaps = 21/314 (6%)
Query: 940 MHLFFQFKTTAPDGLLLFNSGNGN-DFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVND 998
M F+ + DG+LL++ G+ DF+ I L G++ + FD G+G +++ S+ P+
Sbjct: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR--SEDPLTL 58
Query: 999 NQWHNVVVSRDPGNVHTLKIDSRTVTQH--SNGARNLDLKGELYIGGLSKNMFSNLPKLV 1056
WH + VSR N L++D + + + G + +++IGG+ + ++ K
Sbjct: 59 GNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN--YDDVKKNS 115
Query: 1057 ASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWD 1116
F G + + LN R + D + + + C CA+ G C + +
Sbjct: 116 GVLKPFSGSIQKIILNDRTIHVKHDFTSGVN-----VENAAHPCVRAPCAHGGSCRPRKE 170
Query: 1117 GFTCDCTMTSYGGPVCNDPGTTYIFGK---GGALITYTWPP-NDRPSTRMDRLAVGFSTH 1172
G+ CDC + + G C I G + +TY P R S + + F T
Sbjct: 171 GYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTT 229
Query: 1173 QRSAVLV-RVDS-ASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRF 1230
+ +L+ R DS D++ L + G + +N+G+ +I N +DG++H V+
Sbjct: 230 AKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI-MVNGSFNDGRWHRVKA 288
Query: 1231 TRSGGNATLQVDSW 1244
R G + + VD +
Sbjct: 289 VRDGQSGKITVDDY 302
Score = 77.4 bits (189), Expect = 1e-13
Identities = 76/334 (22%), Positives = 139/334 (41%), Gaps = 48/334 (14%)
Query: 519 LDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRA 578
+ FR +G+LL+S GS D+ ++ L GH+ D GSG LR
Sbjct: 5 ITFRPDSGDGVLLYSYD------TGSK------DFLSINLAGGHVEFRFDCGSGTGVLR- 51
Query: 579 SSRKVNDGEWCHVDFQRDGRKGSISVNSRS-TPFLATGDSEILDLESELYLGGLPEGGRV 637
S + G W + R + G + V+ + +A G + +++++GG+P V
Sbjct: 52 SEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDV 111
Query: 638 DLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASA 697
+ + + G ++ + ++ R+ ++ + V V C A
Sbjct: 112 KK-------NSGVLKPFSGSIQKIILNDRTIHVKH--DFTSGVNV-----ENAAHPCVRA 157
Query: 698 PCRNGGVCREGWNRFICDCIGTGFLGRVCEREAT----VLSYDGSMYMKIMLPNAMHTEA 753
PC +GG CR + CDC GF G C++ + + G Y+ P+ + +
Sbjct: 158 PCAHGGSCRPRKEGYDCDC-PLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVS 216
Query: 754 ---EDVSLRFMSQRAYGLMM---ATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSK 807
+V +RF + GL++ + R ++D + L L G + + NL
Sbjct: 217 GSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNL---------GS 267
Query: 808 GPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDN 841
G ++ ND WH V+ VR G+S +++VD+
Sbjct: 268 GVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDD 301
Score = 58.5 bits (140), Expect = 5e-08
Identities = 38/111 (34%), Positives = 59/111 (53%), Gaps = 7/111 (6%)
Query: 941 HLFFQFKTTAPDGLLLFNSGN----GNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPV 996
++F +FKTTA DGLLL+ + +DFI + L G + + ++LG+G + + N
Sbjct: 221 NVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS--F 278
Query: 997 NDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGA-RNLDLKGELYIGGLSK 1046
ND +WH V RD + D T S G R L++ G LY+GG+ +
Sbjct: 279 NDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKE 329
Score = 43.9 bits (102), Expect = 0.001
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 5/113 (4%)
Query: 47 AASSGELSFSLRTNATRALLLYLDDGG---DCDFLELLLVDGRLRLRFTLSCAEPATLQL 103
+ S + +T A LLL+ D + DF+ L L DG L + L A++ +
Sbjct: 216 SGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGV-ASIMV 274
Query: 104 DTPVADDRWHMVLLTRDARRTALAVDG-EARAAEVRSKRREMQVASDLFVGGI 155
+ D RWH V RD + + VD AR + R++ + L+VGG+
Sbjct: 275 NGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGM 327
Score = 32.0 bits (71), Expect = 5.3
Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 5/73 (6%)
Query: 1185 SGLGDYLQLHIDQGTVGVIFNVG--TDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1242
+G D+L +++ G V F+ G T + ++P + G +H +R +R+ N LQVD
Sbjct: 22 TGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL---GNWHELRVSRTAKNGILQVD 78
Query: 1243 SWPVNERYPAGNF 1255
+ E G F
Sbjct: 79 KQKIVEGMAEGGF 91
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 88.2 bits (217), Expect = 6e-17
Identities = 82/344 (23%), Positives = 139/344 (40%), Gaps = 54/344 (15%)
Query: 926 SSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS--GNGNDFIVIELVKGYIHYVFDLGN 983
SS++ L+ + L F T GLL +N +DF+ +ELV G + + G
Sbjct: 1523 SSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNGRLNEKHDFLALELVAGQVRLTYSTGE 1582
Query: 984 GPSLMKGNSDKPVNDNQWHNVVV-----------------SRDPGNVHTLKIDSRTVTQ- 1025
+++ ++D QWH V + S+D V L +D V
Sbjct: 1583 SNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQGPSKD--KVAVLSVDDCDVAVA 1640
Query: 1026 -----------------HSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLAS 1068
++ ++LDL G L +GG+ N+ N P S F GC+
Sbjct: 1641 LQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVP-NLPENFP---VSHKDFIGCMRD 1696
Query: 1069 VDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYG 1128
+ ++GR D+ A + GC C C N G C ++W F+CDC + +G
Sbjct: 1697 LHIDGRRVDMAAFVANN--GTMAGCQAKLHFCDSGPCKNSGFCSERWGSFSCDCPV-GFG 1753
Query: 1129 GPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLG 1188
G C +G +++ + +D + L + F T VL++V +G
Sbjct: 1754 GKDCQLTMAHPHHFRGNGTLSWNF-GSDMAVSVPWYLGLAFRTRATQGVLMQVQ--AGPH 1810
Query: 1189 DYLQLHIDQGTVGVIFNVGT---DDITIDEPNAIVSDGKYHVVR 1229
L +D+G + V G+ + +D+ VSDG++H +R
Sbjct: 1811 STLLCQLDRGLLSVTVTRGSGRASHLLLDQ--VTVSDGRWHDLR 1852
Score = 83.2 bits (204), Expect = 2e-15
Identities = 108/465 (23%), Positives = 175/465 (37%), Gaps = 109/465 (23%)
Query: 485 RCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGS 544
RCE A P P +FV + ++SL F T + +GLL ++ GR
Sbjct: 1512 RCEVAARSFP-----PSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYN-GRLN------ 1559
Query: 545 HSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRAS-SRKVNDGEWCHVDFQ------RDG 597
++ D+ A+EL+ G + L G + + ++DG+W V + D
Sbjct: 1560 ----EKHDFLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDA 1615
Query: 598 RKGSISVNSRSTPFLATGDSEI---------------------------LDLESELYLGG 630
G+ + L+ D ++ LDL L LGG
Sbjct: 1616 LGGAQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGG 1675
Query: 631 LPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRET 690
+P PE + + + ++GC+RDL IDGR D+ G + +
Sbjct: 1676 VPN--------LPENFPVSHK-DFIGCMRDLHIDGRRVDMAAFVANNGTMAGC----QAK 1722
Query: 691 LKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCE---------REATVLSYDGSMYM 741
L C S PC+N G C E W F CDC GF G+ C+ R LS++ M
Sbjct: 1723 LHFCDSGPCKNSGFCSERWGSFSCDC-PVGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDM 1781
Query: 742 KIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRV 801
+ +P + L F ++ G++M + + TL +LD G + +TV
Sbjct: 1782 AVSVPWYL-------GLAFRTRATQGVLMQVQAGPHS-TLLCQLDRGLLSVTVTR----- 1828
Query: 802 GCAPSKGPETLFAGHKLNDNEWHTVRVV-------RRGK-----SLQLSV--DNVTVEGQ 847
+ L ++D WH +R+ RRG SL S+ D + V +
Sbjct: 1829 --GSGRASHLLLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDTMAVGSE 1886
Query: 848 MAGAHMR-LEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQP 891
+ G ++ L + G E P +G + G+ P
Sbjct: 1887 LQGLKVKQLHVGGLPPGSAEE------APQGLVGCIQGVWLGSTP 1925
Score = 73.2 bits (178), Expect = 2e-12
Identities = 135/578 (23%), Positives = 212/578 (36%), Gaps = 100/578 (17%)
Query: 211 NPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGA 270
NPC NGG C G C C F G+ C + + N + + G
Sbjct: 1442 NPCRNGGACA-RREGGYTCVC-RPRFTGEDCELDTEAGRCVPGVCRNGGTCTDAPNGGFR 1499
Query: 271 GRGGAGDVHQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHT 330
+ AG + + E +F + F + + ++L+F T+Q++GL+ +
Sbjct: 1500 CQCPAGGAFEGPRC-EVAARSFPPSSFVMFRGLRQRFHLT---LSLSFATVQQSGLLFYN 1555
Query: 331 GK---SADYVNLSLKSGAVWLVINLGSGAFEALVEP-VNGKFNDNAWHDVRVTR-NLRQH 385
G+ D++ L L +G V L + G +V P V G +D WH V + N +
Sbjct: 1556 GRLNEKHDFLALELVAGQVRLTYSTGES--NTVVSPTVPGGLSDGQWHTVHLRYYNKPRT 1613
Query: 386 AGIGHAMVNKLHYLVTISVDGI----------------LTTTGYTQEDYTMLGSDDFFYI 429
+G A + +SVD G L +
Sbjct: 1614 DALGGAQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLL 1673
Query: 430 GGSPNTADLPGSPVSN-NFMGCLKDV------------VYKNNDFKLELSRLAKEGDPKM 476
GG PN + PVS+ +F+GC++D+ V N ++L
Sbjct: 1674 GGVPNLPE--NFPVSHKDFIGCMRDLHIDGRRVDMAAFVANNGTMAGCQAKLHFCDSGPC 1731
Query: 477 KLQGDLSFRCEDVAALDPVTFESPEAFVALPR-----------WSAKRTGSIS------L 519
K G S R + PV F + + + W+ ++S L
Sbjct: 1732 KNSGFCSERWGSFSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDMAVSVPWYLGL 1791
Query: 520 DFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIK-LRA 578
FRT G+L+ Q AG HS+ +L G L + + GSG L
Sbjct: 1792 AFRTRATQGVLMQVQ-------AGPHST------LLCQLDRGLLSVTVTRGSGRASHLLL 1838
Query: 579 SSRKVNDGEW--CHVDFQRD--GRKGS----ISVN-SRSTPFLATGDSEILDLE-SELYL 628
V+DG W ++ Q + GR+G +S++ S +A G SE+ L+ +L++
Sbjct: 1839 DQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDTMAVG-SELQGLKVKQLHV 1897
Query: 629 GGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSR 688
GGLP G + P G VGC++ +++ L V P C
Sbjct: 1898 GGLPPGSAEEAP-----------QGLVGCIQGVWLGSTPSGSPALLPPSHRVNAEPGCV- 1945
Query: 689 ETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVC 726
CAS PC CR+ W F C C G+ G C
Sbjct: 1946 -VTNACASGPCPPHADCRDLWQTFSCTC-QPGYYGPGC 1981
Score = 51.2 bits (121), Expect = 8e-06
Identities = 50/206 (24%), Positives = 81/206 (39%), Gaps = 22/206 (10%)
Query: 941 HLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQ 1000
+L F+T A G+L+ + ++ +L +G + G+G + V+D +
Sbjct: 1788 YLGLAFRTRATQGVLMQVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGR 1847
Query: 1001 WHNV--VVSRDPGNV---HTLKIDSRTVTQHSNGARNLDLKG----ELYIGGLSKNMFSN 1051
WH++ + +PG H L + A +L+G +L++GGL
Sbjct: 1848 WHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDTMAVGSELQGLKVKQLHVGGLPPGSAEE 1907
Query: 1052 LPKLVASRDGFQGCLASVDLNGR---LPDLIADALHRIGQVERGCDGPSTTCTEESCANQ 1108
P+ G GC+ V L P L+ + HR+ E GC + C C
Sbjct: 1908 APQ------GLVGCIQGVWLGSTPSGSPALLPPS-HRVN-AEPGCV-VTNACASGPCPPH 1958
Query: 1109 GVCLQQWDGFTCDCTMTSYGGPVCND 1134
C W F+C C Y GP C D
Sbjct: 1959 ADCRDLWQTFSCTC-QPGYYGPGCVD 1983
Score = 46.6 bits (109), Expect = 2e-04
Identities = 44/139 (31%), Positives = 61/139 (43%), Gaps = 14/139 (10%)
Query: 693 QCASAPCRNGGVCREGWN-RFICDC-IGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMH 750
+C CRNGG C + N F C C G F G CE A S+ S + +M
Sbjct: 1478 RCVPGVCRNGGTCTDAPNGGFRCQCPAGGAFEGPRCEVAAR--SFPPSSF--VMFRGLRQ 1533
Query: 751 TEAEDVSLRFMSQRAYGLMMAT-TSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGP 809
+SL F + + GL+ E D L LEL GQ++LT + +P
Sbjct: 1534 RFHLTLSLSFATVQQSGLLFYNGRLNEKHDFLALELVAGQVRLTYSTGESNTVVSP---- 1589
Query: 810 ETLFAGHKLNDNEWHTVRV 828
T+ G L+D +WHTV +
Sbjct: 1590 -TVPGG--LSDGQWHTVHL 1605
Score = 40.8 bits (94), Expect = 0.011
Identities = 48/212 (22%), Positives = 82/212 (38%), Gaps = 40/212 (18%)
Query: 1093 CDGPSTTCTEESCANQGVCLQQWDGFTC---------DCTMTSYGG----PVCNDPGTTY 1139
C+ C C N G C ++ G+TC DC + + G VC + GT
Sbjct: 1432 CETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCT 1491
Query: 1140 IFGKGG----------------ALITYTWPPNDRPSTRMDR------LAVGFSTHQRSAV 1177
GG + ++PP+ R R L++ F+T Q+S +
Sbjct: 1492 DAPNGGFRCQCPAGGAFEGPRCEVAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGL 1551
Query: 1178 LVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAI--VSDGKYHVV--RFTRS 1233
L + D+L L + G V + ++ G + T+ P +SDG++H V R+
Sbjct: 1552 LFYNGRLNEKHDFLALELVAGQVRLTYSTGESN-TVVSPTVPGGLSDGQWHTVHLRYYNK 1610
Query: 1234 GGNATLQVDSWPVNERYPAGNFDNERLAIARQ 1265
L P ++ + D+ +A+A Q
Sbjct: 1611 PRTDALGGAQGPSKDKVAVLSVDDCDVAVALQ 1642
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 87.0 bits (214), Expect = 1e-16
Identities = 98/466 (21%), Positives = 179/466 (38%), Gaps = 80/466 (17%)
Query: 480 GDLSFRCEDVAALDPVTFESPE-AFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRA 538
G CE ++ +F S E ++++ + ++ I L F+ +G+L +
Sbjct: 2682 GTTGIYCEQALSISDPSFRSNELSWMSFASFHVRKKTHIQLQFQPLAADGILFY------ 2735
Query: 539 GGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSR-KVNDGEWCHVDFQRDG 597
A H AQ D+ + L++ + L ++G I L + +N W + R G
Sbjct: 2736 ---AAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIILETLQKVTINGSTWHIIKAGRVG 2792
Query: 598 RKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGC 657
+G + ++ + A+ LD ++ Y+GG+ ++L P + + G+ GC
Sbjct: 2793 AEGYLDLDGINVTEKASTKMSSLDTNTDFYIGGVSS---LNLVNPMAIENEPV--GFQGC 2847
Query: 658 VRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCI 717
+R + I+ + L A+G V C C CRNGG C F C C+
Sbjct: 2848 IRQVIINNQELQLTEFG-AKGGSNVGD-CDGTA---CGYNTCRNGGECTVNGTTFSCRCL 2902
Query: 718 -------------------------------------GTGFLGRVCEREA--TVLSYDGS 738
G++GR CE + + + G+
Sbjct: 2903 PDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENKTSFSTAKFMGN 2962
Query: 739 MYMKIMLPN--AMHTEAEDVSLRFMSQRAYGLM--MATTSRESADTLRLELDGGQMKLTV 794
Y+K + PN + + +SL F + + GL+ M E D L + L +K+ V
Sbjct: 2963 SYIKYIDPNYRMRNLQFTTISLNFSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAV 3022
Query: 795 NLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHMR 854
NL R+ S T N+WH V V++ ++ ++N + + H
Sbjct: 3023 NLG-ERISVPMSYNNGTFCC------NKWHHVVVIQNQTLIKAYINNSLILSEDIDPHKN 3075
Query: 855 LEFHNIE----TGIMTERRFISVV-----PSNFIGHLSGLVFNGQP 891
N + G R +++V +NF+G + +VF +P
Sbjct: 3076 FVALNYDGICYLGGFEYGRKVNIVTQEIFKTNFVGKIKDVVFFQEP 3121
Score = 84.3 bits (207), Expect = 9e-16
Identities = 61/226 (26%), Positives = 99/226 (43%), Gaps = 16/226 (7%)
Query: 916 VADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS----GNGNDFIVIELV 971
++DP + S+++ A+ H+ QF+ A DG+L + + DF+ I LV
Sbjct: 2694 ISDPSFRSNELSWMSFASFHVRKKTHIQLQFQPLAADGILFYAAQHLKAQSGDFLCISLV 2753
Query: 972 KGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQH-SNGA 1030
+ ++LG+ +++ +N + WH + R G L +D VT+ S
Sbjct: 2754 NSSVQLRYNLGDRTIILETLQKVTINGSTWHIIKAGR-VGAEGYLDLDGINVTEKASTKM 2812
Query: 1031 RNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNG---RLPDLIADALHRIG 1087
+LD + YIGG+S N + GFQGC+ V +N +L + A +G
Sbjct: 2813 SSLDTNTDFYIGGVSSLNLVNPMAIENEPVGFQGCIRQVIINNQELQLTEFGAKGGSNVG 2872
Query: 1088 QVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCN 1133
CDG T C +C N G C F+C C + + G CN
Sbjct: 2873 D----CDG--TACGYNTCRNGGECTVNGTTFSCRC-LPDWAGNTCN 2911
Score = 68.2 bits (165), Expect = 7e-11
Identities = 99/417 (23%), Positives = 169/417 (40%), Gaps = 57/417 (13%)
Query: 76 DFLELLLVDGRLRLRFTLSCAEPATLQLDT----PVADDRWHMVLLTRDARRTALAVDGE 131
DFL + LV+ ++LR+ L T+ L+T + WH++ R L +DG
Sbjct: 2746 DFLCISLVNSSVQLRYNLG---DRTIILETLQKVTINGSTWHIIKAGRVGAEGYLDLDGI 2802
Query: 132 ARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEP-PFRGLLANLKLGERPPA 190
+ +K + +D ++GG+ L+ + ++ EP F+G + + + +
Sbjct: 2803 NVTEKASTKMSSLDTNTDFYIGGVS---SLNLVNPMAIENEPVGFQGCIRQVIINNQELQ 2859
Query: 191 L--LGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPM 248
L G++G A N C NGG CTV C C + G C++ +
Sbjct: 2860 LTEFGAKGGSNVGDCDGTACGYNTCRNGGECTVNGT-TFSCRCL-PDWAGNTCNQSVSCL 2917
Query: 249 EGPA-HLTL----NSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEF-VATFKGNEFFCY-D 301
H +L S S L + G GR + K F A F GN + Y D
Sbjct: 2918 NNLCLHQSLCIPDQSFSYSCLCTLGWVGR--------YCENKTSFSTAKFMGNSYIKYID 2969
Query: 302 LSHNPIQSSTDEITLAFRTLQRNGLMLHTG----KSADYVNLSLKSGAVWLVINLGSGAF 357
++ I+L F T + GL++ G + D++ + L + + + +NLG
Sbjct: 2970 PNYRMRNLQFTTISLNFSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAVNLG---- 3025
Query: 358 EALVEPV---NGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYT 414
E + P+ NG F N WH V V +N + A +N +++ +D
Sbjct: 3026 ERISVPMSYNNGTFCCNKWHHVVVIQN----QTLIKAYINN-SLILSEDID--------P 3072
Query: 415 QEDYTMLGSDDFFYIGG---SPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRL 468
+++ L D Y+GG + NF+G +KDVV+ +EL +L
Sbjct: 3073 HKNFVALNYDGICYLGGFEYGRKVNIVTQEIFKTNFVGKIKDVVFFQEPKNIELIKL 3129
Score = 66.2 bits (160), Expect = 3e-10
Identities = 88/397 (22%), Positives = 161/397 (40%), Gaps = 76/397 (19%)
Query: 918 DPVTFKSRSSYLALATLQAYASMHLFFQFKT--TAPDGLLLFNSG------NGNDFIVIE 969
D + S +Y ++ + + HL FQ +A L+F +G NG+DF+ +
Sbjct: 2422 DAFGYTSFLAYSRISDISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVG 2481
Query: 970 LVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNG 1029
L+ G + Y ++LG+G + ++ +P+N + + V LK+D
Sbjct: 2482 LLNGSVVYSYNLGSGIASIR---SEPLNLSLGVHTVHLGKFFQEGWLKVDDHKNKSIIAP 2538
Query: 1030 AR--NLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRL---------PDL 1078
R L++ + Y+GG S+ LP ++GFQGC+ ++ + P+
Sbjct: 2539 GRLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCIFTLQVRTEKDGHFRGLGNPEG 2598
Query: 1079 IADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVC------ 1132
+A +GQ ++ C+ C N G C++ C+CT T + G C
Sbjct: 2599 HPNAGRSVGQCH------ASPCSLMKCGNGGTCIESGTSVYCNCT-TGWKGSFCTETVST 2651
Query: 1133 ----NDP------GTTYI-----------FGKGGALITYTWPPNDRPSTRMDRLA-VGF- 1169
+DP G T I G G +D PS R + L+ + F
Sbjct: 2652 CDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALSISD-PSFRSNELSWMSFA 2710
Query: 1170 STHQRSAVLVRVD----SASGL------------GDYLQLHIDQGTVGVIFNVGTDDITI 1213
S H R +++ +A G+ GD+L + + +V + +N+G I +
Sbjct: 2711 SFHVRKKTHIQLQFQPLAADGILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIIL 2770
Query: 1214 DEPNAIVSDGK-YHVVRFTRSGGNATLQVDSWPVNER 1249
+ + +G +H+++ R G L +D V E+
Sbjct: 2771 ETLQKVTINGSTWHIIKAGRVGAEGYLDLDGINVTEK 2807
Score = 55.5 bits (132), Expect = 4e-07
Identities = 44/203 (21%), Positives = 91/203 (44%), Gaps = 19/203 (9%)
Query: 942 LFFQFKTTAPDGLLLFNSGN--GNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDN 999
++ KT + +G +L+++GN G F+ + LV+G + GN +++ +++ +N N
Sbjct: 2175 IYLTIKTNSLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTN 2234
Query: 1000 QWHNVVVSR-----DPGNVHTLKI--DSRTVTQHSNGARNLDLKG---ELYIGGLSKNMF 1049
+ + + PG V +++ D + Q + + + +++G + N+
Sbjct: 2235 AFTPITIRYTTPVGSPGVVCMIEMTADGKPPVQKKDTEISHASQAYFESMFLGHIPANV- 2293
Query: 1050 SNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQG 1109
+ K GF+GC+ + +N + +I +A H G+ C P C C N G
Sbjct: 2294 -QIHKKAGPVYGFRGCILDLQVNNKEFFIIDEARH--GKNIENCHVP--WCAHHLCRNNG 2348
Query: 1110 VCLQQWDGFTCDCTMTSYGGPVC 1132
C+ + C+C Y G +C
Sbjct: 2349 TCISDNENLFCECPRL-YSGKLC 2370
Score = 51.6 bits (122), Expect = 6e-06
Identities = 50/199 (25%), Positives = 85/199 (42%), Gaps = 16/199 (8%)
Query: 530 LLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWC 589
L+F G++ G G D+ A+ LL+G + ++GSG +R+ ++ G
Sbjct: 2461 LIFFTGQKGHGLNGD-------DFLAVGLLNGSVVYSYNLGSGIASIRSEPLNLSLGVHT 2513
Query: 590 HVDFQRDGRKGSISVNS-RSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTA 648
V + ++G + V+ ++ +A G L++ S+ Y+GG E LP A
Sbjct: 2514 -VHLGKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYTPDLLPNG-----A 2567
Query: 649 ALRAGYVGCVRDLFI-DGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCRE 707
+ G+ GC+ L + + RGL +G + C+ C NGG C E
Sbjct: 2568 DFKNGFQGCIFTLQVRTEKDGHFRGLGNPEGHPNAGRSVGQCHASPCSLMKCGNGGTCIE 2627
Query: 708 GWNRFICDCIGTGFLGRVC 726
C+C TG+ G C
Sbjct: 2628 SGTSVYCNCT-TGWKGSFC 2645
Score = 49.7 bits (117), Expect = 2e-05
Identities = 99/445 (22%), Positives = 156/445 (35%), Gaps = 94/445 (21%)
Query: 56 SLRTNATRALLLYLDDGGDC--DFLELLLVDGRLRLRFTLSCAE---------------- 97
+++TN+ +LY +G +C FL L LV+GR +++ ++
Sbjct: 2178 TIKTNSLNGTILY-SNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTNAF 2236
Query: 98 -PATLQLDTPVADDRWH-MVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGI 155
P T++ TPV M+ +T D + D E A +F+G I
Sbjct: 2237 TPITIRYTTPVGSPGVVCMIEMTADGKPPVQKKDTEISHAS-------QAYFESMFLGHI 2289
Query: 156 PPDVRLSALTLSTVKYEPP--FRGLLANLKLGERPPALLGSQGLRGATADPLCAP--ARN 211
P +V++ K P FRG + +L++ + ++ + G + P A +
Sbjct: 2290 PANVQIHK------KAGPVYGFRGCILDLQVNNKEFFII-DEARHGKNIENCHVPWCAHH 2342
Query: 212 PCANGGLCTVLAPGEVGCDCSHTGFGGKFC---SEEEHPMEGPAHLTLNSEVGSLLFSEG 268
C N G C + + C+C + GK C S E +P A S +
Sbjct: 2343 LCRNNGTC-ISDNENLFCECPRL-YSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPY 2400
Query: 269 GAGRGGAGDVHQPTKGKEEFVATFKGNEFFCY----DLS-----HNPIQSSTDEITLAFR 319
G D T+ + F F Y D+S H Q + + L
Sbjct: 2401 GRSGPLCTDAINITQPRFSGTDAFGYTSFLAYSRISDISFHYEFHLKFQLANNHSALQNN 2460
Query: 320 TLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVN----------GKFN 369
+ G H D++ + L +G+V NLGSG EP+N GKF
Sbjct: 2461 LIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASIRSEPLNLSLGVHTVHLGKFF 2520
Query: 370 DNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYI 429
W V +N +I G L + FY+
Sbjct: 2521 QEGWLKVDDHKN------------------KSIIAPGRLVGLNVFSQ----------FYV 2552
Query: 430 GG-SPNTADL--PGSPVSNNFMGCL 451
GG S T DL G+ N F GC+
Sbjct: 2553 GGYSEYTPDLLPNGADFKNGFQGCI 2577
Score = 43.5 bits (101), Expect = 0.002
Identities = 19/40 (47%), Positives = 24/40 (60%), Gaps = 1/40 (2%)
Query: 691 LKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREA 730
L +C S PC + GVC +G N + CDC +GF G CE A
Sbjct: 1005 LDECLSEPCLHDGVCIDGINHYTCDC-KSGFFGTHCETNA 1043
Score = 37.4 bits (85), Expect = 0.13
Identities = 12/26 (46%), Positives = 18/26 (69%)
Query: 691 LKQCASAPCRNGGVCREGWNRFICDC 716
+ +C+S PC+N G C + NRF C+C
Sbjct: 929 INECSSEPCKNNGTCVDLTNRFFCNC 954
Score = 37.0 bits (84), Expect = 0.16
Identities = 24/77 (31%), Positives = 32/77 (41%), Gaps = 17/77 (22%)
Query: 1065 CLASVDLNGRLPDLIADALHRIGQVERGCDGPSTT---------CTEESCANQGVCLQQW 1115
CL++ L+GR +LI + CD T+ CT C N+G C +
Sbjct: 1046 CLSNPCLHGRCTELI-------NEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSA 1098
Query: 1116 DGFTCDCTMTSYGGPVC 1132
GFTC C Y G C
Sbjct: 1099 HGFTCICP-RGYTGAYC 1114
Score = 36.6 bits (83), Expect = 0.22
Identities = 47/226 (20%), Positives = 86/226 (38%), Gaps = 36/226 (15%)
Query: 513 RTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSG 572
RT +I L +T NG +L+S G G + + L++G + G+
Sbjct: 2171 RTVTIYLTIKTNSLNGTILYSNGNNCG-----------KQFLHLFLVEGRPSVKYGCGNS 2219
Query: 573 GIKLRASSR-KVNDGEWCHVDFQRDGRKGS------ISVNSRSTPFLATGDSEILDLES- 624
L S+ +N + + + GS I + + P + D+EI
Sbjct: 2220 QNILTVSANYSINTNAFTPITIRYTTPVGSPGVVCMIEMTADGKPPVQKKDTEISHASQA 2279
Query: 625 ---ELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVG 681
++LG +P ++ P G+ GC+ DL ++ + + + EA+
Sbjct: 2280 YFESMFLGHIPANVQIHKKAGPVY-------GFRGCILDLQVNNKEFFI--IDEARHGKN 2330
Query: 682 VAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCE 727
+ C + CA CRN G C C+C + G++C+
Sbjct: 2331 IEN-CH---VPWCAHHLCRNNGTCISDNENLFCECPRL-YSGKLCQ 2371
Score = 36.2 bits (82), Expect = 0.28
Identities = 16/55 (29%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 685 FCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSM 739
FC +E+ +C PC+N C + + + C+C +G+ G+ C E D M
Sbjct: 767 FCEQES-NECKMNPCKNNSTCTDLYKSYRCECT-SGWTGQNCSEEINECDSDPCM 819
Score = 36.2 bits (82), Expect = 0.28
Identities = 14/39 (35%), Positives = 23/39 (58%), Gaps = 1/39 (2%)
Query: 691 LKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCERE 729
+ +C+S+PC +G C + N ++C C G+ G CE E
Sbjct: 1162 INECSSSPCLHGADCEDHINGYVCKC-QPGWSGHHCENE 1199
Score = 35.4 bits (80), Expect = 0.48
Identities = 32/131 (24%), Positives = 54/131 (41%), Gaps = 8/131 (6%)
Query: 946 FKTTAPDGLLLFNS---GNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWH 1002
F TT +GL+++ NDF+ I L + +LG S+ ++ N+WH
Sbjct: 2986 FSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAVNLGERISVPMSYNNGTFCCNKWH 3045
Query: 1003 NVVVSRD----PGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVAS 1058
+VVV ++ ++ I S + H N L+ G Y+GG N+
Sbjct: 3046 HVVVIQNQTLIKAYINNSLILSEDIDPHKNFVA-LNYDGICYLGGFEYGRKVNIVTQEIF 3104
Query: 1059 RDGFQGCLASV 1069
+ F G + V
Sbjct: 3105 KTNFVGKIKDV 3115
Score = 34.7 bits (78), Expect = 0.82
Identities = 14/38 (36%), Positives = 20/38 (52%), Gaps = 1/38 (2%)
Query: 691 LKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCER 728
+ C S PC N G C++ + F C C G+ G CE+
Sbjct: 1080 INDCTSIPCMNEGFCQKSAHGFTCIC-PRGYTGAYCEK 1116
Score = 34.3 bits (77), Expect = 1.1
Identities = 14/40 (35%), Positives = 19/40 (47%), Gaps = 1/40 (2%)
Query: 1093 CDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVC 1132
C+ C+ E C N G C+ + F C+C Y GP C
Sbjct: 925 CEIEINECSSEPCKNNGTCVDLTNRFFCNCE-PEYHGPFC 963
Score = 33.9 bits (76), Expect = 1.4
Identities = 14/52 (26%), Positives = 24/52 (46%), Gaps = 13/52 (25%)
Query: 691 LKQCASAPCRNGGVCREGWNRFICDCI-------------GTGFLGRVCERE 729
+ +CAS PC+NG C + + C C+ G++G CE++
Sbjct: 682 IDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQD 733
Score = 33.9 bits (76), Expect = 1.4
Identities = 15/33 (45%), Positives = 20/33 (60%), Gaps = 3/33 (9%)
Query: 686 CSRETLKQCASAPCRNGGVCREGW--NRFICDC 716
CS E + +C S PC NGG+C E +F+C C
Sbjct: 806 CSEE-INECDSDPCMNGGLCHESTIPGQFVCLC 837
Score = 32.3 bits (72), Expect = 4.1
Identities = 12/36 (33%), Positives = 18/36 (50%)
Query: 1093 CDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYG 1128
C+ C E C + GVC+ + +TCDC +G
Sbjct: 1001 CEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFG 1036
>gi|219842266 usherin isoform B [Homo sapiens]
Length = 5202
Score = 84.0 bits (206), Expect = 1e-15
Identities = 102/427 (23%), Positives = 167/427 (39%), Gaps = 72/427 (16%)
Query: 292 FKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHT---GKSADYVNLSLKSGAVWL 348
F GN + + S +P+ + I +FRT GL++ G +Y L LK G ++
Sbjct: 1522 FIGNGYCKFPSSTHPVNTDFTGIKASFRTKVPEGLIVFAASPGNQEEYFALQLKKGRLYF 1581
Query: 349 VINLGSGAFEALVEPVNGK-FNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGI 407
+ + E +GK ++D WH++ R H G I++DGI
Sbjct: 1582 LFDPQGSPVEVTTTNDHGKQYSDGKWHEIIAIR----HQAFGQ-----------ITLDGI 1626
Query: 408 LTTTGYTQEDYTMLGSDDFFYIGGSPNTADL---PGSPVSNNFMGCLKDVVYKNN----- 459
T + T++G + ++GG P + + + F+GCLKDV + N
Sbjct: 1627 YTGSSAILNGSTVIGDNTGVFLGGLPRSYTILRKDPEIIQKGFVGCLKDVHFMKNYNPSA 1686
Query: 460 -----DFKLELSRL----AKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWS 510
D++ ++ + EG P +G F L P F F
Sbjct: 1687 IWEPLDWQSSEEQINVYNSWEGCPASLNEG-AQFLGAGFLELHPYMFHGGMNF------- 1738
Query: 511 AKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLD-- 568
IS FRT + NGLLLF + D+ AMEL G L L+
Sbjct: 1739 -----EISFKFRTDQLNGLLLFVYNK------------DGPDFLAMELKSGILTFRLNTS 1781
Query: 569 MGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYL 628
+ + L N G+W V +++G S SVN +GD ++ + S +Y+
Sbjct: 1782 LAFTQVDLLLGLSYCN-GKWNKVIIKKEGSFISASVNGLMKHASESGDQPLV-VNSPVYV 1839
Query: 629 GGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDL-FIDGRSRDLRGLAEAQGAVGVAPFCS 687
GG+P+ L L G+ GC++D+ F G +L ++ V + S
Sbjct: 1840 GGIPQ------ELLNSYQHLCLEQGFGGCMKDVKFTRGAVVNLASVSSGAVRVNLDGCLS 1893
Query: 688 RETLKQC 694
++ C
Sbjct: 1894 TDSAVNC 1900
Score = 49.7 bits (117), Expect = 2e-05
Identities = 36/132 (27%), Positives = 67/132 (50%), Gaps = 11/132 (8%)
Query: 946 FKTTAPDGLLLF--NSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSD--KPVNDNQW 1001
F+T P+GL++F + GN ++ ++L KG ++++FD P + +D K +D +W
Sbjct: 1548 FRTKVPEGLIVFAASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGKQYSDGKW 1607
Query: 1002 HNVVVSRDP--GNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGL--SKNMFSNLPKLVA 1057
H ++ R G + TL + NG+ + +++GGL S + P+++
Sbjct: 1608 HEIIAIRHQAFGQI-TLDGIYTGSSAILNGSTVIGDNTGVFLGGLPRSYTILRKDPEII- 1665
Query: 1058 SRDGFQGCLASV 1069
+ GF GCL V
Sbjct: 1666 -QKGFVGCLKDV 1676
Score = 47.8 bits (112), Expect = 9e-05
Identities = 65/324 (20%), Positives = 133/324 (41%), Gaps = 36/324 (11%)
Query: 815 GHKLNDNEWHTVRVVRRGKSLQLSVDNV-----------TVEGQMAGAHMRLEFHNIETG 863
G + +D +WH + +R Q+++D + TV G G + +
Sbjct: 1599 GKQYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILNGSTVIGDNTGVFLG----GLPRS 1654
Query: 864 IMTERRFISVVPSNFIGHLSGLVFNG--------QPYMDQCKDGDITYCELNARFGLRAI 915
R+ ++ F+G L + F +P Q + I N+ G A
Sbjct: 1655 YTILRKDPEIIQKGFVGCLKDVHFMKNYNPSAIWEPLDWQSSEEQINV--YNSWEGCPAS 1712
Query: 916 VADPVTFKSRSSYLALATLQAYASMH--LFFQFKTTAPDGLLLF-NSGNGNDFIVIELVK 972
+ + F + +L L + M+ + F+F+T +GLLLF + +G DF+ +EL
Sbjct: 1713 LNEGAQFLG-AGFLELHPYMFHGGMNFEISFKFRTDQLNGLLLFVYNKDGPDFLAMELKS 1771
Query: 973 GYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARN 1032
G + + + + + + +W+ V++ ++ G+ + ++ +G +
Sbjct: 1772 GILTFRLNTSLAFTQVDLLLGLSYCNGKWNKVIIKKE-GSFISASVNGLMKHASESGDQP 1830
Query: 1033 LDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDL-NGRLPDLIADALHRIGQVER 1091
L + +Y+GG+ + + ++ L + GF GC+ V G + +L A G V
Sbjct: 1831 LVVNSPVYVGGIPQELLNSYQHLCLEQ-GFGGCMKDVKFTRGAVVNL---ASVSSGAVRV 1886
Query: 1092 GCDGPSTTCTEESC-ANQGVCLQQ 1114
DG +T + +C N + + Q
Sbjct: 1887 NLDGCLSTDSAVNCRGNDSILVYQ 1910
Score = 47.0 bits (110), Expect = 2e-04
Identities = 32/109 (29%), Positives = 55/109 (50%), Gaps = 2/109 (1%)
Query: 52 ELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCA-EPATLQLDTPVADD 110
E+SF RT+ LLL++ + DFL + L G L R S A L L +
Sbjct: 1739 EISFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLSYCNG 1798
Query: 111 RWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDV 159
+W+ V++ ++ + +V+G + A S + + V S ++VGGIP ++
Sbjct: 1799 KWNKVIIKKEGSFISASVNGLMKHAS-ESGDQPLVVNSPVYVGGIPQEL 1846
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 82.4 bits (202), Expect = 3e-15
Identities = 79/323 (24%), Positives = 126/323 (39%), Gaps = 60/323 (18%)
Query: 896 CKDGDIT--YCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDG 953
C GD YC++ R +F + S ++ L+ L F T DG
Sbjct: 1355 CPSGDFEKPYCQVTTR-----------SFPAHS-FITFRGLRQRFHFTLALSFATKERDG 1402
Query: 954 LLLFNS--GNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRD-- 1009
LLL+N +DF+ +E+++ + F G + + V+D QWH V +
Sbjct: 1403 LLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNK 1462
Query: 1010 --------PGNVHTLKIDSRTVTQHSNGA-----------------------RNLDLKGE 1038
P K+ TV G ++LDL G
Sbjct: 1463 PLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLDLTGP 1522
Query: 1039 LYIGGLSKNMFSNLPKLVASR-DGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPS 1097
L +GG+ +LP+ R F GC+ ++ ++ R D+ AD + G V GC
Sbjct: 1523 LLLGGVP-----DLPESFPVRMRQFVGCMRNLQVDSRHIDM-ADFIANNGTVP-GCPAKK 1575
Query: 1098 TTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDR 1157
C +C N G C+ QWD F+C+C + +GG C G +L+ W
Sbjct: 1576 NVCDSNTCHNGGTCVNQWDAFSCECPL-GFGGKSCAQEMANPQHFLGSSLV--AWHGLSL 1632
Query: 1158 PSTRMDRLAVGFSTHQRSAVLVR 1180
P ++ L++ F T Q VL++
Sbjct: 1633 PISQPWYLSLMFRTRQADGVLLQ 1655
Score = 74.7 bits (182), Expect = 7e-13
Identities = 89/344 (25%), Positives = 142/344 (41%), Gaps = 68/344 (19%)
Query: 516 SISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIK 575
+++L F T E +GLLL++ GR ++ D+ A+E++ + L G
Sbjct: 1390 TLALSFATKERDGLLLYN-GR----------FNEKHDFVALEVIQEQVQLTFSAGESTTT 1438
Query: 576 LRAS-SRKVNDGEWCHVDFQR-------------------------DG-------RKGSI 602
+ V+DG+W V + DG R GS+
Sbjct: 1439 VSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSV 1498
Query: 603 SVN-SRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDL 661
N S + G + LDL L LGG+P+ PE + +R +VGC+R+L
Sbjct: 1499 LGNYSCAAQGTQGGSKKSLDLTGPLLLGGVPD--------LPESFPVRMRQ-FVGCMRNL 1549
Query: 662 FIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGF 721
+D R D+ G V P C + C S C NGG C W+ F C+C GF
Sbjct: 1550 QVDSRHIDMADFIANNGTV---PGCPAKK-NVCDSNTCHNGGTCVNQWDAFSCEC-PLGF 1604
Query: 722 LGRVCERE-ATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADT 780
G+ C +E A + GS + + ++ +SL F +++A G+++ +R T
Sbjct: 1605 GGKSCAQEMANPQHFLGSSLVAWHGLSLPISQPWYLSLMFRTRQADGVLLQAITR-GRST 1663
Query: 781 LRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWH 824
+ L+L G + L+V G L G + ND +WH
Sbjct: 1664 ITLQLREGHVMLSVE------GTGLQASSLRLEPG-RANDGDWH 1700
Score = 61.2 bits (147), Expect = 8e-09
Identities = 124/580 (21%), Positives = 198/580 (34%), Gaps = 142/580 (24%)
Query: 206 CAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLF 265
C P C NGG C L G CDC F +C PAH +
Sbjct: 1332 CTPG--VCKNGGTCVNLLVGGFKCDCPSGDFEKPYCQVTTRSF--PAHSFI--------- 1378
Query: 266 SEGGAGRGGAGDVHQPTKGKEEFVATFKG-NEFFCYDLSHNPIQSSTDEITLAFRTLQRN 324
TF+G + F + L+ L+F T +R+
Sbjct: 1379 -------------------------TFRGLRQRFHFTLA------------LSFATKERD 1401
Query: 325 GLMLHTGK---SADYVNLSLKSGAVWLVINLGSGAFEALVEP-VNGKFNDNAWHDVRVTR 380
GL+L+ G+ D+V L + V L + G V P V G +D WH V++
Sbjct: 1402 GLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGEST--TTVSPFVPGGVSDGQWHTVQLKY 1459
Query: 381 NLRQHAG-IGHAMVNKLHYLVTISVDGILT-------------------TTGYTQEDYTM 420
+ G G + ++VDG T T G +++ +
Sbjct: 1460 YNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLDL 1519
Query: 421 LGSDDFFYIGGSPNTADLPGS-PVS-NNFMGCLKDVVYKNNDFKLE---LSRLAKEGDPK 475
G +GG P DLP S PV F+GC++++ + + + G P
Sbjct: 1520 TGP---LLLGGVP---DLPESFPVRMRQFVGCMRNLQVDSRHIDMADFIANNGTVPGCPA 1573
Query: 476 MKLQGDLS--------------FRCEDVAALDPVT----FESPEAFV--ALPRWSA---- 511
K D + F CE + +P+ F+ +L W
Sbjct: 1574 KKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFLGSSLVAWHGLSLP 1633
Query: 512 -KRTGSISLDFRTTEPNGLLL--FSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLD 568
+ +SL FRT + +G+LL ++GR ++L +GH+ L ++
Sbjct: 1634 ISQPWYLSLMFRTRQADGVLLQAITRGRST---------------ITLQLREGHVMLSVE 1678
Query: 569 -MGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELY 627
G LR + NDG+W H G + + L+
Sbjct: 1679 GTGLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEGNLGPRLHGLH 1738
Query: 628 LGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQG-AVGVAPFC 686
L + GG +P P + G+ GC++ + + + L + G ++ V C
Sbjct: 1739 LSNITVGG---IPGP----AGGVARGFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQGC 1791
Query: 687 SRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVC 726
S C S PC C W+ + C C G+ G C
Sbjct: 1792 SLPD--PCDSNPCPANSYCSNDWDSYSCSC-DPGYYGDNC 1828
Score = 50.1 bits (118), Expect = 2e-05
Identities = 89/385 (23%), Positives = 140/385 (36%), Gaps = 100/385 (25%)
Query: 53 LSFSLRTNATRALLLYLDDGGDC-DFLELLLVDGRLRLRFTLSCAEPATLQLDTP--VAD 109
L+ S T LLLY + DF+ L ++ +++L F+ T+ P V+D
Sbjct: 1391 LALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAG-ESTTTVSPFVPGGVSD 1449
Query: 110 DRWHMVLLT----------------RDARRTALAVDGEARAAEVR--------------- 138
+WH V L + + + VDG +R
Sbjct: 1450 GQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGT 1509
Query: 139 --SKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQG 196
++ + + L +GG+P L S F G + NL++ R +
Sbjct: 1510 QGGSKKSLDLTGPLLLGGVPD------LPESFPVRMRQFVGCMRNLQVDSRHIDMADFIA 1563
Query: 197 LRGATADPLCAPAR------NPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEG 250
G P C PA+ N C NGG C V C+C GFGGK C++E M
Sbjct: 1564 NNGTV--PGC-PAKKNVCDSNTCHNGGTC-VNQWDAFSCECP-LGFGGKSCAQE---MAN 1615
Query: 251 PAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVATFKGNEFFCYDLSHNPIQSS 310
P H +S V A G + + QP
Sbjct: 1616 PQHFLGSSLV---------AWHGLSLPISQPW---------------------------- 1638
Query: 311 TDEITLAFRTLQRNGLMLHT-GKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFN 369
++L FRT Q +G++L + + L L+ G V L + G+G + + G+ N
Sbjct: 1639 --YLSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVE-GTGLQASSLRLEPGRAN 1695
Query: 370 DNAWHDVRVTRNLRQHAGIGHAMVN 394
D WH ++ L G GHA+++
Sbjct: 1696 DGDWHHAQLA--LGASGGPGHAILS 1718
Score = 49.3 bits (116), Expect = 3e-05
Identities = 66/247 (26%), Positives = 99/247 (40%), Gaps = 23/247 (9%)
Query: 900 DITYCELNARFGLRAI---VADPVTFKSRSSYLALATLQAYASM--HLFFQFKTTAPDGL 954
D CE FG ++ +A+P F SS +A L S +L F+T DG+
Sbjct: 1594 DAFSCECPLGFGGKSCAQEMANPQHFLG-SSLVAWHGLSLPISQPWYLSLMFRTRQADGV 1652
Query: 955 LLFNSGNGNDFIVIELVKGYIHY-VFDLGNGPSLMKGNSDKPVNDNQWHNVVV----SRD 1009
LL G I ++L +G++ V G S ++ + ND WH+ + S
Sbjct: 1653 LLQAITRGRSTITLQLREGHVMLSVEGTGLQASSLRLEPGR-ANDGDWHHAQLALGASGG 1711
Query: 1010 PGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASV 1069
PG+ L D Q + G L G L++ ++ VA GF+GCL V
Sbjct: 1712 PGHA-ILSFDYGQ--QRAEGNLGPRLHG-LHLSNITVGGIPGPAGGVAR--GFRGCLQGV 1765
Query: 1070 DLNGRLPDLIADALHRIGQ---VERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTS 1126
++ P+ + G+ VE+GC P C C C WD ++C C
Sbjct: 1766 RVSDT-PEGVNSLDPSHGESINVEQGCSLPDP-CDSNPCPANSYCSNDWDSYSCSCDPGY 1823
Query: 1127 YGGPVCN 1133
YG N
Sbjct: 1824 YGDNCTN 1830
Score = 44.7 bits (104), Expect = 8e-04
Identities = 40/136 (29%), Positives = 59/136 (43%), Gaps = 11/136 (8%)
Query: 1097 STTCTEESCANQGVCLQQW-DGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPN 1155
S CT C N G C+ GF CDC + P C TT F + IT+
Sbjct: 1329 SGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYCQ--VTTRSF-PAHSFITFRGLRQ 1385
Query: 1156 DRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDE 1215
T LA+ F+T +R +L+ + D++ L + Q V + F+ G T+
Sbjct: 1386 RFHFT----LALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVSP 1441
Query: 1216 --PNAIVSDGKYHVVR 1229
P VSDG++H V+
Sbjct: 1442 FVPGG-VSDGQWHTVQ 1456
Score = 36.2 bits (82), Expect = 0.28
Identities = 43/176 (24%), Positives = 69/176 (39%), Gaps = 26/176 (14%)
Query: 693 QCASAPCRNGGVCREGW-NRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIM-LPNAMH 750
+C C+NGG C F CDC F C + T S+ ++ L H
Sbjct: 1331 RCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYC--QVTTRSFPAHSFITFRGLRQRFH 1388
Query: 751 TEAEDVSLRFMSQRAYGLMMAT-TSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGP 809
++L F ++ GL++ E D + LE+ Q++LT + +P
Sbjct: 1389 F---TLALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVSP---- 1441
Query: 810 ETLFAGHKLNDNEWHTVRVVRRGKSL-----------QLSVDNVTVEGQMAGAHMR 854
F ++D +WHTV++ K L + V VTV+G G +R
Sbjct: 1442 ---FVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALR 1494
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 80.1 bits (196), Expect = 2e-14
Identities = 107/511 (20%), Positives = 199/511 (38%), Gaps = 104/511 (20%)
Query: 690 TLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAM 749
++ C PC NGG C+ G + + C C G G+ CE + M + PN
Sbjct: 3938 SVNYCECNPCFNGGSCQSGVDSYYCHC-PFGVFGKHCELNSYGFEELSYMEFPSLDPNNN 3996
Query: 750 HTEAEDVSLRFMSQRAYGLMMATTSRESADT---LRLELDGGQMKLTVNLDCLRVGCAPS 806
+ + ++F + +++ L++ ++ D L LE+ +++ + NL
Sbjct: 3997 Y-----IYVKFATIKSHALLLYNYDNQTGDRAEFLALEIAEERLRFSYNL---------G 4042
Query: 807 KGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGA------------HMR 854
G L K++D +HTV R G + L+VD+ + E Q G +
Sbjct: 4043 SGTYKLTTMKKVSDGHFHTVIARRAGMAASLTVDSCS-ENQEPGYCTVSNVAVSDDWTLD 4101
Query: 855 LEFHNIETGIMTE-----RRFISVVPSNFIGHLSGLVFNGQPY-----------MDQCK- 897
++ + + G + +R V +F+G + NG+P +DQC
Sbjct: 4102 VQPNRVTVGGIRSLEPILQRRGHVESHDFVGCIMEFAVNGRPLEPSQALAAQGILDQCPR 4161
Query: 898 -DGDIT-------------------YCE--LNARFGLRAIVADPVTF---KSRSSY---- 928
+G T +C+ L ++ +++ D K R Y
Sbjct: 4162 LEGACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCEKSVTPDTALSLEGKGRLDYHMSQ 4221
Query: 929 -----------LALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHY 977
L A L+ + L +F+T + +G+L+ + N + +++ G +++
Sbjct: 4222 NEKREYLLRQSLRGAMLEPFGVNSLEVKFRTRSENGVLIHIQESSN-YTTVKIKNGKVYF 4280
Query: 978 VFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKID---SRTVTQHSNGARNLD 1034
D G + + + V D WH ++ ++ G L +D +R + + LD
Sbjct: 4281 TSDAGIAGKVERNIPEVYVADGHWHTFLIGKN-GTATVLSVDRIYNRDIIHPTQDFGGLD 4339
Query: 1035 LKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGR-LPDLIADALHRIGQ----V 1089
+ + +GG+ N A GF GC+AS+ G LP +L I + V
Sbjct: 4340 VL-TISLGGIPPNQAHR----DAQTAGFDGCIASMWYGGESLPFSGKHSLASISKTDPSV 4394
Query: 1090 ERGCDGPSTTCTEESCANQGVCLQQWDGFTC 1120
+ GC GP+ C C +C+ QW + C
Sbjct: 4395 KIGCRGPNI-CASNPCWGDLLCINQWYAYRC 4424
Score = 78.6 bits (192), Expect = 5e-14
Identities = 84/362 (23%), Positives = 149/362 (41%), Gaps = 72/362 (19%)
Query: 517 ISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKL 576
I + F T + + LLL++ + G RA++ A+E+ + L ++GSG KL
Sbjct: 3998 IYVKFATIKSHALLLYNYDNQTG---------DRAEFLALEIAEERLRFSYNLGSGTYKL 4048
Query: 577 RASSRKVNDGEWCHVDFQRDGRKGSISVNSRS---------TPFLATGDSEILDLE-SEL 626
+ +KV+DG + V +R G S++V+S S +A D LD++ + +
Sbjct: 4049 -TTMKKVSDGHFHTVIARRAGMAASLTVDSCSENQEPGYCTVSNVAVSDDWTLDVQPNRV 4107
Query: 627 YLGG-------LPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGA 679
+GG L G V+ +VGC+ + ++GR + AQG
Sbjct: 4108 TVGGIRSLEPILQRRGHVE------------SHDFVGCIMEFAVNGRPLEPSQALAAQGI 4155
Query: 680 VGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREA---TVLSYD 736
+ P C +PC++GG C + W+ C C G G+ CE+ T LS +
Sbjct: 4156 LDQCPRLEGA----CTRSPCQHGGTCMDYWSWQQCHC-KEGLTGKYCEKSVTPDTALSLE 4210
Query: 737 GSMYMKIMLPNAMHTE----------------AEDVSLRFMSQRAYGLMMATTSRESADT 780
G + + E + ++F ++ G+++ +ES++
Sbjct: 4211 GKGRLDYHMSQNEKREYLLRQSLRGAMLEPFGVNSLEVKFRTRSENGVLIHI--QESSNY 4268
Query: 781 LRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD 840
+++ G++ T D G PE A D WHT + + G + LSVD
Sbjct: 4269 TTVKIKNGKVYFT--SDAGIAGKVERNIPEVYVA-----DGHWHTFLIGKNGTATVLSVD 4321
Query: 841 NV 842
+
Sbjct: 4322 RI 4323
Score = 74.3 bits (181), Expect = 9e-13
Identities = 88/372 (23%), Positives = 154/372 (41%), Gaps = 54/372 (14%)
Query: 903 YCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFN---- 958
+CELN+ +G + SY+ +L + +++ +F T LLL+N
Sbjct: 3972 HCELNS-YGFEEL-----------SYMEFPSLDPNNN-YIYVKFATIKSHALLLYNYDNQ 4018
Query: 959 SGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKI 1018
+G+ +F+ +E+ + + + ++LG+G K + K V+D +H V+ R G +L +
Sbjct: 4019 TGDRAEFLALEIAEERLRFSYNLGSGT--YKLTTMKKVSDGHFHTVIARR-AGMAASLTV 4075
Query: 1019 DSRTVTQH------SNGARNLDLKGELYIGGLSKNMFSNLPKLVASRD-----GFQGCLA 1067
DS + Q SN A + D ++ ++ +L ++ R F GC+
Sbjct: 4076 DSCSENQEPGYCTVSNVAVSDDWTLDVQPNRVTVGGIRSLEPILQRRGHVESHDFVGCIM 4135
Query: 1068 SVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSY 1127
+NGR P + AL G +++ C CT C + G C+ W C C
Sbjct: 4136 EFAVNGR-PLEPSQALAAQGILDQ-CPRLEGACTRSPCQHGGTCMDYWSWQQCHC-KEGL 4192
Query: 1128 GGPVCNDPGT--TYIFGKGGALITYTWPPND------RPSTR--------MDRLAVGFST 1171
G C T T + +G + Y N+ R S R ++ L V F T
Sbjct: 4193 TGKYCEKSVTPDTALSLEGKGRLDYHMSQNEKREYLLRQSLRGAMLEPFGVNSLEVKFRT 4252
Query: 1172 HQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVG-TDDITIDEPNAIVSDGKYHVVRF 1230
+ VL+ + +S +Y + I G V + G + + P V+DG +H
Sbjct: 4253 RSENGVLIHIQESS---NYTTVKIKNGKVYFTSDAGIAGKVERNIPEVYVADGHWHTFLI 4309
Query: 1231 TRSGGNATLQVD 1242
++G L VD
Sbjct: 4310 GKNGTATVLSVD 4321
Score = 59.7 bits (143), Expect = 2e-08
Identities = 82/344 (23%), Positives = 129/344 (37%), Gaps = 56/344 (16%)
Query: 59 TNATRALLLYLDD---GGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDT--PVADDRWH 113
T + ALLLY D G +FL L + + RLR + L T +L T V+D +H
Sbjct: 4004 TIKSHALLLYNYDNQTGDRAEFLALEIAEERLRFSYNLGSG---TYKLTTMKKVSDGHFH 4060
Query: 114 MVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEP 173
V+ R +L VD + E SD + DV+ + +T+ ++
Sbjct: 4061 TVIARRAGMAASLTVDSCSENQEPGYCTVSNVAVSDDWT----LDVQPNRVTVGGIRSLE 4116
Query: 174 P------------FRGLLANLKLGERP---PALLGSQGLRGATADPLCAPARNPCANGGL 218
P F G + + RP L +QG+ A R+PC +GG
Sbjct: 4117 PILQRRGHVESHDFVGCIMEFAVNGRPLEPSQALAAQGILDQCPRLEGACTRSPCQHGGT 4176
Query: 219 CTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDV 278
C + C C G GK+C + P S G GR D
Sbjct: 4177 CMDYWSWQQ-CHCKE-GLTGKYCEKSVTP--------------DTALSLEGKGRL---DY 4217
Query: 279 HQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVN 338
H K E++ N ++ + FRT NG+++H +S++Y
Sbjct: 4218 HMSQNEKREYLLRQSLRGAMLEPFGVNSLE-------VKFRTRSENGVLIHIQESSNYTT 4270
Query: 339 LSLKSGAVWLVINLG-SGAFEALVEPVNGKFNDNAWHDVRVTRN 381
+ +K+G V+ + G +G E + V D WH + +N
Sbjct: 4271 VKIKNGKVYFTSDAGIAGKVERNIPEV--YVADGHWHTFLIGKN 4312
Score = 49.3 bits (116), Expect = 3e-05
Identities = 57/244 (23%), Positives = 94/244 (38%), Gaps = 57/244 (23%)
Query: 516 SISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMG-SGGI 574
S+ + FRT NG+L+ Q + ++Y +++ +G +Y D G +G +
Sbjct: 4245 SLEVKFRTRSENGVLIHIQ--------------ESSNYTTVKIKNGKVYFTSDAGIAGKV 4290
Query: 575 KLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLA--TGDSEILDLESELYLGGLP 632
+ V DG W ++G +SV+ + T D LD+ + + LGG+P
Sbjct: 4291 ERNIPEVYVADGHWHTFLIGKNGTATVLSVDRIYNRDIIHPTQDFGGLDVLT-ISLGGIP 4349
Query: 633 EGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRS------RDLRGLAEAQGAVGVA--- 683
P + A AG+ GC+ ++ G S L +++ +V +
Sbjct: 4350 ---------PNQAHRDAQTAGFDGCIASMWYGGESLPFSGKHSLASISKTDPSVKIGCRG 4400
Query: 684 -PFCSRETL------------------KQCASAPCRNGGVCREGWNR-FICDCIGTGFLG 723
C+ CAS PC+NGG C G + F C C G
Sbjct: 4401 PNICASNPCWGDLLCINQWYAYRCVPPGDCASHPCQNGGSCEPGLHSGFTCSC-PDSHTG 4459
Query: 724 RVCE 727
R CE
Sbjct: 4460 RTCE 4463
Score = 45.4 bits (106), Expect = 5e-04
Identities = 52/213 (24%), Positives = 86/213 (40%), Gaps = 16/213 (7%)
Query: 1041 IGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALH---RIGQVERGCDGPS 1097
+GG S + RD CL S NG + + + + G + C+
Sbjct: 3881 VGGFSCSCPDGFTGRACERD-INECLQSPCKNGAICQNFPGSFNCVCKTGYTGKMCESSV 3939
Query: 1098 TTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDR 1157
C C N G C D + C C +G C + G ++Y P+
Sbjct: 3940 NYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKH-CE------LNSYGFEELSYMEFPSLD 3992
Query: 1158 PSTRMDRLAVGFSTHQRSAVLV-RVDSASG-LGDYLQLHIDQGTVGVIFNVGTDDITIDE 1215
P+ + V F+T + A+L+ D+ +G ++L L I + + +N+G+ +
Sbjct: 3993 PNNNY--IYVKFATIKSHALLLYNYDNQTGDRAEFLALEIAEERLRFSYNLGSGTYKLTT 4050
Query: 1216 PNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNE 1248
VSDG +H V R+G A+L VDS N+
Sbjct: 4051 MKK-VSDGHFHTVIARRAGMAASLTVDSCSENQ 4082
Score = 39.3 bits (90), Expect = 0.033
Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Query: 691 LKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCERE 729
+ +C +PC +GG C F C C GF GR CER+
Sbjct: 3863 IDECLPSPCHSGGTCHNLVGGFSCSC-PDGFTGRACERD 3900
Score = 37.0 bits (84), Expect = 0.16
Identities = 49/219 (22%), Positives = 90/219 (41%), Gaps = 41/219 (18%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTP---VAD 109
L RT + +L+++ + + + + + +G++ FT ++ + P VAD
Sbjct: 4246 LEVKFRTRSENGVLIHIQESSN--YTTVKIKNGKVY--FTSDAGIAGKVERNIPEVYVAD 4301
Query: 110 DRWHMVLLTRDARRTALAVDGEARAAEVRSKRR--EMQVASDLFVGGIPPD-VRLSALT- 165
WH L+ ++ T L+VD + + + V + + +GGIPP+ A T
Sbjct: 4302 GHWHTFLIGKNGTATVLSVDRIYNRDIIHPTQDFGGLDVLT-ISLGGIPPNQAHRDAQTA 4360
Query: 166 -----LSTVKY---EPPFRGLLANLKLGERPPAL-LGSQGLRGATADPL----------- 205
++++ Y PF G + + + P++ +G +G ++P
Sbjct: 4361 GFDGCIASMWYGGESLPFSGKHSLASISKTDPSVKIGCRGPNICASNPCWGDLLCINQWY 4420
Query: 206 ---CAP----ARNPCANGGLCTVLAPGEVGCDC--SHTG 235
C P A +PC NGG C C C SHTG
Sbjct: 4421 AYRCVPPGDCASHPCQNGGSCEPGLHSGFTCSCPDSHTG 4459
>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
sapiens]
Length = 3118
Score = 79.3 bits (194), Expect = 3e-14
Identities = 149/754 (19%), Positives = 277/754 (36%), Gaps = 139/754 (18%)
Query: 547 SAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNS 606
SA+ D+ A+E+ G + L D+GSG ++ ++D W + R GR G+ISV +
Sbjct: 2188 SAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRA 2247
Query: 607 RSTPFLATGDS----------EILDLESE--LYLGGLPEGGRVDLPLPPEVWTAALRAGY 654
P + S ILD+++ L++GGL G++ V T +
Sbjct: 2248 LDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGLT--GKLKKADAVRVIT------F 2299
Query: 655 VGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFIC 714
GC+ + + D + L E +G
Sbjct: 2300 TGCMGETYFDNKPIGLWNFREKEG------------------------------------ 2323
Query: 715 DCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTS 774
DC G +V + E T+ +DG Y + P + V +F + + L+M +
Sbjct: 2324 DCKGCTVSPQVEDSEGTI-QFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLAT 2382
Query: 775 RESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKS 834
R+ D + +EL G +K++ +L G ++ + ND +W + + R K
Sbjct: 2383 RDLRDFMSVELTDGHIKVSYDL---------GSGMASVVSNQNHNDGKWKSFTLSRIQKQ 2433
Query: 835 LQLSVDNV----------TVEGQMAGAHMRLEFHNIETGIMTERRFISVVP-SNFIGHLS 883
+S+ ++ + G G ++ + G+ T R V + G L
Sbjct: 2434 ANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLRPEVNLKKYSGCLK 2493
Query: 884 GLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLF 943
+ + PY Y + L + V+F + ++ L+ + +
Sbjct: 2494 DIEISRTPYNILSSP---DYVGVTKGCSLENVYT--VSF-PKPGFVELSPVPIDVGTEIN 2547
Query: 944 FQFKTTAPDGLLLFNSG------------NGNDFIVIELVKGYIHYVFDLGNGPSLMKGN 991
F T G++L SG G + VI L +G + L G M+
Sbjct: 2548 LSFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLE--VHLSTGARTMRKI 2605
Query: 992 SDKP----VNDNQWHNVVVSRDPGNVHTLKID-SRTVTQHSNGARNLDLKGELYIGGLSK 1046
+P +D + H+V V R G + T+++D +R Q+ + +++K +L++GG
Sbjct: 2606 VIRPEPNLFHDGREHSVHVERTRG-IFTVQVDENRRYMQNLTVEQPIEVK-KLFVGGAPP 2663
Query: 1047 NMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCA 1106
P + + F+GC+ ++ +N D + + R C E+ A
Sbjct: 2664 EF---QPSPLRNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGR-CAHQKLREDEDGAA 2719
Query: 1107 NQGVCLQ----QWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRM 1162
+ +Q F + ++G I K L +R
Sbjct: 2720 PAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFGL------------SRN 2767
Query: 1163 DRLAVGFSTHQRSAVL-----VRVDSASGL---------GDYLQLHIDQGTVGVIFNVGT 1208
+A+ F + L VR ++ SGL D+ + + G +++G+
Sbjct: 2768 SHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGS 2827
Query: 1209 DDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1242
D P I +DG++H ++ RS L VD
Sbjct: 2828 GDTHTMIPTKI-NDGQWHKIKIMRSKQEGILYVD 2860
Score = 66.2 bits (160), Expect = 3e-10
Identities = 171/820 (20%), Positives = 289/820 (35%), Gaps = 126/820 (15%)
Query: 300 YDLSHNPIQ--SSTDEITLAFRTLQRNGLMLH--TGKSADYVNLSLKSGAVWLVINLGSG 355
Y L PI+ + + FRT + L+++ T D++++ L G + + +LGSG
Sbjct: 2348 YALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGSG 2407
Query: 356 AFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQ 415
+ N ND W ++R +++ A I ++ T + I T++
Sbjct: 2408 MASVVS---NQNHNDGKWKSFTLSR-IQKQANISIVDID------TNQEENIATSSSGNN 2457
Query: 416 EDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPK 475
L +DD Y GG P +L + GCLKD+ + + LS G K
Sbjct: 2458 FGLD-LKADDKIYFGGLPTLRNLRPEVNLKKYSGCLKDIEISRTPYNI-LSSPDYVGVTK 2515
Query: 476 MKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQG 535
E+V V+F P FV L I+L F T +G++L G
Sbjct: 2516 -------GCSLENVYT---VSFPKP-GFVELSPVPIDVGTEINLSFSTKNESGIILLGSG 2564
Query: 536 RRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQR 595
+A Y+ + L G L + L G+ ++ + N
Sbjct: 2565 GTPAPPRRKRRQTGQA-YYVILLNRGRLEVHLSTGARTMRKIVIRPEPN--------LFH 2615
Query: 596 DGRKGSISVNSRSTPFLATGDS-----EILDLESELYLGGLPEGGRVDLPLPPEVWTAAL 650
DGR+ S+ V F D + L +E + + L GG PPE + L
Sbjct: 2616 DGREHSVHVERTRGIFTVQVDENRRYMQNLTVEQPIEVKKLFVGG-----APPEFQPSPL 2670
Query: 651 R--AGYVGCVRDLFID-----------------GRSRDLRGLAEAQGAVGVAPFCSRETL 691
R + GC+ +L I+ GR + + GA E +
Sbjct: 2671 RNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPV 2730
Query: 692 KQCA---SAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNA 748
A P G C + IG+ G + D + ++ +
Sbjct: 2731 PTPAFPTPTPVLTHGPCAAESEPAL--LIGSKQFGLSRNSHIAIAFDDTKVKNRLTIELE 2788
Query: 749 MHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKG 808
+ TEAE GL+ AD ++L G + +L G
Sbjct: 2789 VRTEAES-----------GLLFYMARINHADFATVQLRNGLPYFSYDL---------GSG 2828
Query: 809 PETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD---NVTVEGQMA---GAHMRLEFHNIET 862
K+ND +WH ++++R + L VD N T+ + A L +
Sbjct: 2829 DTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILDVVGMLYVGGLPI 2888
Query: 863 GIMTERRFISVVPSNFIGHLSGLVFNGQP--YMDQCKDGDITYCELNARFGLRAIVADPV 920
T R I V + G + L P + C NA+ G
Sbjct: 2889 NYTTRR--IGPVTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFANAQRG--------T 2938
Query: 921 TFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFD 980
F A+ + + + F+F+TT G+LL S D + IE++ + + D
Sbjct: 2939 YFDGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFHVD 2998
Query: 981 LGNGPSLMKGNSDKP--VNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHS--NGARNLDLK 1036
G G ++ P + D QWH V ++ + L +D V S + + D
Sbjct: 2999 NGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIE-LTVDGNQVEAQSPNPASTSADTN 3057
Query: 1037 GELYIGGLSKN-----MFSNLPKLVASRDGFQGCLASVDL 1071
+++GG + + +++P F+GC+ S+ L
Sbjct: 3058 DPVFVGGFPDDLKQFGLTTSIP--------FRGCIRSLKL 3089
Score = 57.0 bits (136), Expect = 2e-07
Identities = 110/538 (20%), Positives = 186/538 (34%), Gaps = 99/538 (18%)
Query: 109 DDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLST 168
D R H V + R + VD R + + + ++V LFVGG PP+ + S L
Sbjct: 2616 DGREHSVHVERTRGIFTVQVDENRRYMQNLTVEQPIEVKK-LFVGGAPPEFQPSPL---- 2670
Query: 169 VKYEPPFRGLLANLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVG 228
+ PPF G + NL + P + A +G AP E+
Sbjct: 2671 -RNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGRCAHQKLREDEDGA-----APAEIV 2724
Query: 229 CDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEF 288
+ P+ PA T + H P + E
Sbjct: 2725 I--------------QPEPVPTPAFPTPTPVL-----------------THGPCAAESEP 2753
Query: 289 VATFKGNEFFCYDLSHNPIQSSTDE------ITLAFRTLQRNGLMLHTGK--SADYVNLS 340
+F SH I + I L RT +GL+ + + AD+ +
Sbjct: 2754 ALLIGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQ 2813
Query: 341 LKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLV 400
L++G + +LGSG ++ K ND WH +++ R+ ++ GI
Sbjct: 2814 LRNGLPYFSYDLGSGDTHTMIPT---KINDGQWHKIKIMRSKQE--GI------------ 2856
Query: 401 TISVDGILTTTGYTQEDYTMLGSDDFFYIGGSP-NTADLPGSPVSNNFMGCLKDVVYKNN 459
+ VDG T + + +L Y+GG P N PV+ + GC++++
Sbjct: 2857 -LYVDGASNRT-ISPKKADILDVVGMLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMAEA 2914
Query: 460 DFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISL 519
LE P F A F+ A+ + +
Sbjct: 2915 PADLE--------QPTSSFHVGTCF----ANAQRGTYFDGTGFAKAVGGFKVGLDLLVEF 2962
Query: 520 DFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSG---GIKL 576
+FRTT G+LL S+Q+ D +E++D L +D G+G +
Sbjct: 2963 EFRTTTTTGVLL-------------GISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAVYD 3009
Query: 577 RASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGD-SEILDLESELYLGGLPE 633
+ DG+W V + + ++V+ + S D +++GG P+
Sbjct: 3010 AGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPD 3067
Score = 53.9 bits (128), Expect = 1e-06
Identities = 72/317 (22%), Positives = 128/317 (40%), Gaps = 61/317 (19%)
Query: 947 KTTAPDGLLLF-NSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVV 1005
KT D LL + S DF+ IE+ KG + +++D+G+G ++ D ++D+ W+ +V
Sbjct: 2175 KTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVE-YPDLTIDDSYWYRIV 2233
Query: 1006 VSRD--PGNVHTLKIDSRTV-----TQHSNG-----ARNLDLKGELYIGGLSKNMFSNLP 1053
SR G + +D T HS ++D L++GGL+
Sbjct: 2234 ASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGLT-------- 2285
Query: 1054 KLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQ 1113
G+L ADA+ I GC G E N+ + L
Sbjct: 2286 -------------------GKLKK--ADAVRVI--TFTGCMG------ETYFDNKPIGLW 2316
Query: 1114 QWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALIT--YTWPPNDRPSTRMDRLAVGFST 1171
+ DC + V + GT G+G AL++ W PN + + F T
Sbjct: 2317 NFREKEGDCKGCTVSPQVEDSEGTIQFDGEGYALVSRPIRWYPN------ISTVMFKFRT 2370
Query: 1172 HQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFT 1231
SA+L+ + + L D++ + + G + V +++G+ ++ N +DGK+ +
Sbjct: 2371 FSSSALLMYL-ATRDLRDFMSVELTDGHIKVSYDLGSGMASV-VSNQNHNDGKWKSFTLS 2428
Query: 1232 RSGGNATLQVDSWPVNE 1248
R A + + N+
Sbjct: 2429 RIQKQANISIVDIDTNQ 2445
Score = 50.8 bits (120), Expect = 1e-05
Identities = 36/139 (25%), Positives = 59/139 (42%), Gaps = 5/139 (3%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRW 112
+ +RT A LL Y+ DF + L +G + L + T+ + T + D +W
Sbjct: 2785 IELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSGDTHTM-IPTKINDGQW 2843
Query: 113 HMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYE 172
H + + R + L VDG + K + V L+VGG+P + + + V Y
Sbjct: 2844 HKIKIMRSKQEGILYVDGASNRTISPKKADILDVVGMLYVGGLP--INYTTRRIGPVTYS 2901
Query: 173 PPFRGLLANLKLGERPPAL 191
G + NL + E P L
Sbjct: 2902 --IDGCVRNLHMAEAPADL 2918
Score = 45.8 bits (107), Expect = 4e-04
Identities = 43/164 (26%), Positives = 68/164 (41%), Gaps = 13/164 (7%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAE-PATLQLDTP--VAD 109
+ F RT T +LL + D + + ++D +L A P + D
Sbjct: 2960 VEFEFRTTTTTGVLLGISSQ-KMDGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPGHLCD 3018
Query: 110 DRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASD-LFVGGIPPDVRLSALTLST 168
+WH V + R L VDG A+ + +D +FVGG P D++ LT S
Sbjct: 3019 GQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSI 3078
Query: 169 VKYEPPFRGLLANLKLGE---RPPALLGSQGLRGATADPLCAPA 209
PFRG + +LKL + +P + ++ L P+ PA
Sbjct: 3079 -----PFRGCIRSLKLTKGTGKPLEVNFAKALELRGVQPVSCPA 3117
Score = 38.9 bits (89), Expect = 0.043
Identities = 39/181 (21%), Positives = 80/181 (44%), Gaps = 22/181 (12%)
Query: 32 GGGPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRF 91
G G +R RW S+ + F RT ++ ALL+YL DF+ + L DG +++ +
Sbjct: 2345 GEGYALVSRPIRWYPNIST--VMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSY 2402
Query: 92 TLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAV--------DGEARAAEVRSKRRE 143
L + A++ + D +W L+R ++ +++ + A ++ + +
Sbjct: 2403 DLG-SGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLD 2461
Query: 144 MQVASDLFVGGIPPDVRLSALTLSTVKYE---PPFRGLLANLKLGERPPALLGSQGLRGA 200
++ ++ GG+P TL ++ E + G L ++++ P +L S G
Sbjct: 2462 LKADDKIYFGGLP--------TLRNLRPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGV 2513
Query: 201 T 201
T
Sbjct: 2514 T 2514
Score = 32.3 bits (72), Expect = 4.1
Identities = 18/79 (22%), Positives = 41/79 (51%), Gaps = 1/79 (1%)
Query: 1163 DRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSD 1222
+ + V T +L + SA + D+L + + +G V +++VG+ ++ P+ + D
Sbjct: 2168 NNIVVNVKTAVADNLLFYLGSAKFI-DFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDD 2226
Query: 1223 GKYHVVRFTRSGGNATLQV 1241
++ + +R+G N T+ V
Sbjct: 2227 SYWYRIVASRTGRNGTISV 2245
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,974,101
Number of Sequences: 37866
Number of extensions: 4028492
Number of successful extensions: 23199
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 143
Number of HSP's successfully gapped in prelim test: 683
Number of HSP's that attempted gapping in prelim test: 14843
Number of HSP's gapped (non-prelim): 6431
length of query: 1712
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1596
effective length of database: 13,855,062
effective search space: 22112678952
effective search space used: 22112678952
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.