Guide to the Human Genome
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Search of human proteins with 94721321

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|94721321 coiled-coil domain containing 11 [Homo sapiens]
         (514 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|94721321 coiled-coil domain containing 11 [Homo sapiens]          1001   0.0  
gi|148746195 trichohyalin [Homo sapiens]                              131   2e-30
gi|219803769 trichoplein [Homo sapiens]                               129   5e-30
gi|14150056 trichoplein [Homo sapiens]                                129   5e-30
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...   107   3e-23
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...   105   1e-22
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...   104   2e-22
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...   103   4e-22
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    97   4e-20
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    96   6e-20
gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]        94   2e-19
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    91   2e-18
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    91   3e-18
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        91   3e-18
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        91   3e-18
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         91   3e-18
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         91   3e-18
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         91   3e-18
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         91   3e-18
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         91   3e-18
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         91   3e-18
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    91   3e-18
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho...    89   1e-17
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho...    89   1e-17
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho...    89   1e-17
gi|217416394 hyaluronan-mediated motility receptor isoform b [Ho...    89   1e-17
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     88   2e-17
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...    87   3e-17
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m...    87   3e-17
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m...    87   4e-17

>gi|94721321 coiled-coil domain containing 11 [Homo sapiens]
          Length = 514

 Score = 1001 bits (2587), Expect = 0.0
 Identities = 514/514 (100%), Positives = 514/514 (100%)

Query: 1   MYSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERD 60
           MYSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERD
Sbjct: 1   MYSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERD 60

Query: 61  RLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKK 120
           RLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKK
Sbjct: 61  RLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKK 120

Query: 121 ETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEER 180
           ETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEER
Sbjct: 121 ETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEER 180

Query: 181 KAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITS 240
           KAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITS
Sbjct: 181 KAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITS 240

Query: 241 IKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ 300
           IKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ
Sbjct: 241 IKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ 300

Query: 301 QEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEF 360
           QEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEF
Sbjct: 301 QEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEF 360

Query: 361 DRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQK 420
           DRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQK
Sbjct: 361 DRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQK 420

Query: 421 HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAAN 480
           HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAAN
Sbjct: 421 HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAAN 480

Query: 481 KMCLDKVQEVLSTHQVLPQNIHPMRKACPSKLPP 514
           KMCLDKVQEVLSTHQVLPQNIHPMRKACPSKLPP
Sbjct: 481 KMCLDKVQEVLSTHQVLPQNIHPMRKACPSKLPP 514


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  131 bits (329), Expect = 2e-30
 Identities = 100/381 (26%), Positives = 200/381 (52%), Gaps = 14/381 (3%)

Query: 95  EERRNKLRELLALEENEYFTEMQ-LKKETIEEKKDRMR-EKTKLLKEKNEKERQDFVAEK 152
           EE   + REL   EE     E Q L++E  EE++ + R  + + L+ K E+ER++   E+
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321

Query: 153 LDQQ-FRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLA 211
            +QQ  RE+ EE R + L   Q+   E R+ Q+   +E  R+    EQ   +  EE+R  
Sbjct: 322 REQQERREQQEERREQQLRREQE---ERREQQLRREQEEERR----EQQLRREQEEERRE 374

Query: 212 KEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENE 271
           ++ R  Q+ RR+++L    +L    Q+   +  R+  QL +E++ R       Q++ E E
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR----REQQLRREQE 430

Query: 272 QDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQK 331
           ++  +++  ++     L++  +ER + +++E   E+    +  Q+  +D +EE  ++  K
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490

Query: 332 REDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVD 391
            E+  R ++   +    RRE+E+ +E+   R  EE++ ++    +++LR E+E RR+ + 
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550

Query: 392 EVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQL 451
           +    ++L+ + + QR  +EQEER  +     E  ++   + ++     QRL +E  ++L
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL 610

Query: 452 QMQIAYQQQSQEAEKEEKRRE 472
           + +   +Q+ +  E EE+RR+
Sbjct: 611 EQEERREQRLKREEPEEERRQ 631



 Score =  114 bits (285), Expect = 2e-25
 Identities = 102/427 (23%), Positives = 215/427 (50%), Gaps = 42/427 (9%)

Query: 95   EERRNKLRELLALEENEYFTEMQLKKETIEEKKDRM----REKTKLLKEKNEKERQ-DFV 149
            E  R +L     L E     E QL+ E  ++++ R      EK +  +++ E+E++  F+
Sbjct: 778  ERGRQRLSARPPLREQR---ERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFL 834

Query: 150  AEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQ------MFSK 203
             E+   Q RER ++L+ E   + + +  E R++Q    ++  R +L EE+      +++K
Sbjct: 835  EEEEQLQRRERAQQLQEEEDGLQEDQ--ERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK 892

Query: 204  LWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNN 263
               +++L KE++  QE   + +  E  +     Q    +  R+  QL +EEE  L E   
Sbjct: 893  PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE---RQYREEEQLQQEEEQLLREERE 949

Query: 264  AQIKHENEQDMLKKQKAKQETRTIL-QKALQERIEHIQQEYRDEQDLNMKLVQ------- 315
             + + E E+   K +K +Q+   +L ++  + R +  +++YR+E++L  +  Q       
Sbjct: 950  KRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE 1009

Query: 316  -RALQDLQEEADKK---KQKREDMIREQKIYHKYLA---QRREEEKAQEKEFDRILEEDK 368
             R  Q+ + +  KK   +Q+ E ++RE++   +      Q REEE+ Q++E   + EE +
Sbjct: 1010 KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERE 1069

Query: 369  AKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKE 428
             ++  E +++ R E+E +++         +L  +E  +R  +E+E +  E++ + +  ++
Sbjct: 1070 TRRRQELERQYRKEEELQQE-------EEQLLREEPEKRRRQERERQCREEEELQQEEEQ 1122

Query: 429  LNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQ 488
            L  EE+E   RRQ L ++YR++ ++Q   +Q  +E  ++ +R+E E      +    + +
Sbjct: 1123 LLREEREK-RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEE 1181

Query: 489  EVLSTHQ 495
            ++L   Q
Sbjct: 1182 QLLREEQ 1188



 Score =  112 bits (280), Expect = 8e-25
 Identities = 104/400 (26%), Positives = 204/400 (51%), Gaps = 42/400 (10%)

Query: 95   EERRNKLREL--LALEENEYFTEMQLKKETIE-----EKKDRMR-EKTKLLKEKNEKERQ 146
            +ER  K RE   L  EE +   E + K+   E      KKD ++ E+ +LL+E+ EK R 
Sbjct: 984  QEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR- 1042

Query: 147  DFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWE 206
                ++ ++Q+RE  EEL+ E     ++ + EER+ +    +EL RQ   EE++  +  +
Sbjct: 1043 ---LQERERQYREE-EELQQE----EEQLLGEERETRR--RQELERQYRKEEELQQEEEQ 1092

Query: 207  EDRLAKEKREAQEARRQ----KELMENTRLGLNAQITSIKAQ------RQATQLLKEEEA 256
              R   EKR  QE  RQ    +EL +     L  +    + Q      R+  ++ +EEE 
Sbjct: 1093 LLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQ 1152

Query: 257  RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
             L E    + + E E+   ++++ +QE   +L++  ++R +  +++YR+E++L  +  ++
Sbjct: 1153 LLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQ 1212

Query: 317  ALQDLQEEADKKKQ---KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
              +D  + +D K Q   ++E+ +R+ K+Y K     +  +    +  DR  ++D    L 
Sbjct: 1213 RYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLG 1272

Query: 374  EKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEE 433
            E+ +  R E+E RR    +     + Q++ + Q+EAK ++ ++ E+       K+L  EE
Sbjct: 1273 EQQERDR-EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEE-------KQLLREE 1324

Query: 434  KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
            +E   RRQ   +++R+  + Q+  +++ Q   ++E+ R+F
Sbjct: 1325 REEKRRRQETDRKFRE--EEQLLQEREEQPLRRQERDRKF 1362



 Score =  111 bits (277), Expect = 2e-24
 Identities = 114/495 (23%), Positives = 225/495 (45%), Gaps = 62/495 (12%)

Query: 24  RSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARI 83
           R +  K Q  E  L++  RS Q+       ++  + +R +    +  + ++       R+
Sbjct: 515 REQRLKRQEEEERLQQRLRSEQQ-------LRREQEERREQLLKREEEKRLEQERREQRL 567

Query: 84  KDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEK 143
           K   +     + +R  + R+     E E   E +LK+E +E  +   R + +L +E+ E+
Sbjct: 568 KREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEE 627

Query: 144 ERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSK 203
           ER+  + +  +Q                      EER+ Q    E+  R+    EQ   +
Sbjct: 628 ERRQQLLKSEEQ----------------------EERRQQQLRREQQERR----EQRLKR 661

Query: 204 LWEEDRLAKE-KREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESN 262
             EE+RL +  KRE +E RR++EL E  +     +I S +  +   QL  E +AR  +  
Sbjct: 662 EEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS-RIPKWQWQLESEADARQSKVY 720

Query: 263 NAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQE-----------------YRD 305
           +   K E ++   ++++ ++   + LQ   +ER    QQE                  R 
Sbjct: 721 SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780

Query: 306 EQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQE--KEFDRI 363
            Q L+ +   R  ++ Q  A++++Q+ +  + E++   +   QRRE EK  +  +E +++
Sbjct: 781 RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL 840

Query: 364 LEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKE-------QEERA 416
              ++A++L E++  L+ ++E RR          + Q++E+ +R           QE+  
Sbjct: 841 QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900

Query: 417 MEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAG 476
            EQ+ + E  +EL  EE+E   RRQ   ++YR++ Q+Q   +Q  +E  ++ +R+E E  
Sbjct: 901 KEQQLLQEEEEELQREEREK-RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ 959

Query: 477 VAANKMCLDKVQEVL 491
              +K    K +++L
Sbjct: 960 YRKDKKLQQKEEQLL 974



 Score =  110 bits (276), Expect = 2e-24
 Identities = 120/482 (24%), Positives = 234/482 (48%), Gaps = 60/482 (12%)

Query: 24   RSKPPKGQGAEHHLE-RIRRSHQ---KHNAILASIKSSERDRLKA-----EWDQHNDCKI 74
            R +  K +  E  LE R++R H+   +   +    +   R+R+K+     +W   ++   
Sbjct: 655  REQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADA 714

Query: 75   LDSLVRARI-KDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKET---------IE 124
              S V +R  K   Q      EE+R +    L  +E E     Q ++E           E
Sbjct: 715  RQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAE 774

Query: 125  EKKDRMREKTKL---LKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERK 181
            EK +R R++      L+E+ E++ +    ++ +Q+F    EE         +++   ER+
Sbjct: 775  EKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKE------QRRRQRRERE 828

Query: 182  AQIAFNEELSR-------QKLVEEQMFSKLWEEDRLAKEKREAQEARRQ-KELMENTRLG 233
             ++ F EE  +       Q+L EE+   +  +E R ++E+R  Q+ R Q +E  +  R  
Sbjct: 829  KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHT 888

Query: 234  LNAQITSIKAQRQATQLLKEEEARLV-ESNNAQIKHENEQDMLKKQKAKQETRTILQKAL 292
            L A+    +  R+  QLL+EEE  L  E    + + E E+   ++++ +QE   +L+   
Sbjct: 889  LYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLR--- 945

Query: 293  QERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREE 352
            +ER +  +QE   +   + KL Q+  Q L EE +K++++     RE+K         REE
Sbjct: 946  EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE----REKKY--------REE 993

Query: 353  EKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQ 412
            E+ Q++E   + EE + ++  E +++ R + E +++         +L  +E+ +R  +E+
Sbjct: 994  EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE-------EEQLLREEREKRRLQER 1046

Query: 413  EERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRRE 472
            E +  E++ + +  ++L  EE+E   RRQ L ++YRK+ ++Q   +Q  +E  ++ +R+E
Sbjct: 1047 ERQYREEEELQQEEEQLLGEERET-RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE 1105

Query: 473  FE 474
             E
Sbjct: 1106 RE 1107



 Score =  110 bits (275), Expect = 3e-24
 Identities = 103/407 (25%), Positives = 206/407 (50%), Gaps = 59/407 (14%)

Query: 96   ERRNKLRELLALEENEYFT------EMQLKKETIEEKKDRMREKTKL--------LKEKN 141
            +RR + +EL  LEE E         ++Q +++ ++E ++R R + +         L+E+ 
Sbjct: 823  QRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEER 882

Query: 142  EKERQDFVAEK-LDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQM 200
            ++ R    A+  L +Q R+  + L+ E   + Q++  E+R+ Q     E  RQ   EEQ+
Sbjct: 883  KRRRHTLYAKPALQEQLRKEQQLLQEEEEEL-QREEREKRRRQ-----EQERQYREEEQL 936

Query: 201  FSKLWEEDRLAKEKREAQEARRQ----KELMENTRLGLNAQITSIKAQ------RQATQL 250
              +  +  R  +EKR  QE  RQ    K+L +     L  +    + Q      R+  +L
Sbjct: 937  QQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEEL 996

Query: 251  LKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQER-IEHIQQEYRDEQDL 309
             +EEE  L E    + + E E+   KK + +QE   +L++  ++R ++  +++YR+E++L
Sbjct: 997  QQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEEL 1056

Query: 310  NMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA 369
                        QEE     ++RE   R Q++  +Y    R+EE+ Q++E   + EE + 
Sbjct: 1057 Q-----------QEEEQLLGEERETR-RRQELERQY----RKEEELQQEEEQLLREEPEK 1100

Query: 370  KKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKEL 429
            ++  E++++ R E+E +++         +L  +E+ +R  +E E +  E++ + +  ++L
Sbjct: 1101 RRRQERERQCREEEELQQE-------EEQLLREEREKRRRQELERQYREEEEVQQEEEQL 1153

Query: 430  NCEEKENFARRQRLAQEYRKQLQMQIAYQQ---QSQEAEKEEKRREF 473
              EE E   RRQ L ++YR++ ++Q   +Q   + QE  ++E+ R++
Sbjct: 1154 LREEPEK-RRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199



 Score =  106 bits (265), Expect = 4e-23
 Identities = 91/371 (24%), Positives = 193/371 (52%), Gaps = 26/371 (7%)

Query: 96  ERRNKLRELLALEENEYFTEMQLKKETIEEKKDR-MREKTKLLKEKNEKERQDFVAE--- 151
           E+  +  + L  E+ E   E QL++E  EE++++ +R + +L +E+  +  Q    E   
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQL 401

Query: 152 KLDQQFRERCEELRVELLSIHQ--KKVCEERKAQIAFNEELSRQKLVEEQMFSKLW---- 205
           + +QQ R   +  R + L   Q  ++  EE + +    +E   Q+L  EQ   + W    
Sbjct: 402 RREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKRE 461

Query: 206 -EEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNA 264
            E +R  +E+R+ Q  R Q+E      L L  +    + +R+  QL +E+E    E    
Sbjct: 462 EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE----ERREQ 517

Query: 265 QIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEE 324
           ++K + E++ L+++   ++     Q+  +E++   ++E R EQ+   + ++R     QEE
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE----QEE 573

Query: 325 ADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKE 384
              +  KRE+  R+Q++  K   + R E++ + +E +R+ +E++ ++  ++++    E+E
Sbjct: 574 RRDQLLKREEERRQQRL--KREQEERLEQRLKREEVERLEQEERREQRLKREEP---EEE 628

Query: 385 ARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLA 444
            R+QL+      ++ + Q++L+RE +E+ E+ ++++   E L++    E E   R Q LA
Sbjct: 629 RRQQLLKSE--EQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELA 686

Query: 445 QEYRKQLQMQI 455
           +E ++Q + +I
Sbjct: 687 EEEQEQARERI 697



 Score =  106 bits (265), Expect = 4e-23
 Identities = 108/483 (22%), Positives = 234/483 (48%), Gaps = 62/483 (12%)

Query: 38   ERIRRSHQKHNAILAS--IKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIE 95
            +R+RR  ++   +     ++  ER++   +  Q  D K  +   +   ++  + F    +
Sbjct: 1381 QRLRRQERERKFLKEEQQLRCQEREQ---QLRQDRDRKFREEEQQLSRQERDRKFREEEQ 1437

Query: 96   ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEK----ERQDFVAE 151
            + R + RE   LEE +   + + +K   EE+  + RE+ +L +++ ++    E Q    +
Sbjct: 1438 QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ 1497

Query: 152  KLDQQFRE---RCEELRVELLSIHQKKVCEERKAQIAFNEE-LSRQKLVEEQMFS---KL 204
            + D++FRE   R +E   + L   Q+   ++R+ +    E+ L RQ+  +++      K 
Sbjct: 1498 ERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKF 1557

Query: 205  WEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNA 264
             EE++L +E+ E Q +R++++     +  L  Q   ++ Q Q  + +++E+    +    
Sbjct: 1558 REEEQLRQEREEQQLSRQERD----RKFRLEEQ--KVRRQEQERKFMEDEQQLRRQEGQQ 1611

Query: 265  QIKHENEQDMLKKQKAKQET-----------RTILQKALQERIEHIQQEYRDEQDLNMKL 313
            Q++ E ++   + ++  QE            R  L++  Q R +  +Q+ R ++D   + 
Sbjct: 1612 QLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFRE 1671

Query: 314  VQRALQDLQE------EADKKKQKREDMIREQKIYHKYLAQ-------------RREEEK 354
             ++ LQ+ +E      E D+K ++ E  +R Q+   K+L +             R EE+ 
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQL 1731

Query: 355  AQEKEFDRILEEDKAKKLAEKD--KELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQ 412
             QE E +++  +++ +K+ E++  +  R E++ RRQ  D     RK + +E+L++E +EQ
Sbjct: 1732 RQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERD-----RKFREEEQLRQEREEQ 1786

Query: 413  EERAMEQKHINESLKELNCEEKENFARRQRLAQEYR---KQLQMQIAYQQQSQEAEKEEK 469
            + R+ E        ++L  E +E   R Q+   +YR   +QLQ++   Q+  QE +++ +
Sbjct: 1787 QLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR 1846

Query: 470  RRE 472
              E
Sbjct: 1847 AEE 1849



 Score =  105 bits (263), Expect = 8e-23
 Identities = 96/381 (25%), Positives = 193/381 (50%), Gaps = 40/381 (10%)

Query: 115 EMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQK 174
           + QL++E  + ++ + +E+ + L E  E+  +    E+L+Q+ R+R +E   EL    Q+
Sbjct: 126 DRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQ---ERLEQRDRQRRDE---ELW--RQR 177

Query: 175 KVCEERKAQIAFNEELSRQKLVEEQMF--------SKLWEEDRLAKEKREAQEARRQKEL 226
           +  +ER+ + A  E+L   K  E + F         +L E  R  +E+++ Q   RQ  +
Sbjct: 178 QEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRV 237

Query: 227 MENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRT 286
            +             + +++ T L KEEE    E    Q + + E++ L+K + ++  R 
Sbjct: 238 FQEEE--------EKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRE 289

Query: 287 ILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMI-REQKIYHKY 345
             ++  Q++    +Q+ R +Q+   +  Q   ++ QE  ++++++RE  + REQ+   + 
Sbjct: 290 RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQ 349

Query: 346 LAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARR--QLVDEVMCTRKLQV-- 401
             +R +EE+ +E++  R  EE++ ++   ++++LR E++ RR  QL  E    R+ Q+  
Sbjct: 350 QLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 409

Query: 402 QEKLQRE---------AKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQ 452
           +++L+RE          +EQEE   EQKH  E  ++    E+E   RR  L +E   +  
Sbjct: 410 EQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE--RRDWLKREEETERH 467

Query: 453 MQIAYQQQSQEAEKEEKRREF 473
            Q   +QQ +  ++EE+R  +
Sbjct: 468 EQERRKQQLKRDQEEERRERW 488



 Score =  105 bits (262), Expect = 1e-22
 Identities = 107/424 (25%), Positives = 211/424 (49%), Gaps = 62/424 (14%)

Query: 102 RELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLK--EKNEKERQDFVAEKLDQQFRE 159
           RE     E +   E QL++E  EE+ ++  E+ +  +  ++ ++ER+D++  K +++   
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWL--KREEETER 466

Query: 160 RCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQE 219
             +E R + L   Q++   ER  ++   EE   Q+   EQ   +  EE R  + KR+ +E
Sbjct: 467 HEQERRKQQLKRDQEEERRERWLKLE-EEERREQQERREQQLRREQEERREQRLKRQEEE 525

Query: 220 ARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQ-IKHENEQ---DML 275
            R Q+      RL    Q+   + +R+   L +EEE RL +    Q +K E E+    +L
Sbjct: 526 ERLQQ------RLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579

Query: 276 KKQKAKQETRT-------ILQKALQERIEHIQQEYRDEQDLNM-KLVQRALQDLQEEADK 327
           K+++ +++ R        + Q+  +E +E ++QE R EQ L   +  +   Q L +  ++
Sbjct: 580 KREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQ 639

Query: 328 KKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEED-KAKKLAEKDKE-------- 378
           ++++++ + REQ+   +   +R EEE+  E+   R  EE+ + ++LAE+++E        
Sbjct: 640 EERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS 699

Query: 379 --------LRLEKEARRQLV------DEVMCTRKLQVQEKLQREAK---EQEERAMEQKH 421
                   L  E +AR+  V       E    R+ Q +++ +RE++   ++EERA  Q+ 
Sbjct: 700 RIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQ 759

Query: 422 INESLKELNCE---EKENFARRQRLAQE--YRKQLQMQIAYQQQSQ--------EAEKEE 468
             E  ++   +   E+++   RQRL+     R+Q + Q+  +++ Q        E EKE+
Sbjct: 760 EEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQ 819

Query: 469 KRRE 472
           +RR+
Sbjct: 820 RRRQ 823



 Score =  102 bits (254), Expect = 8e-22
 Identities = 108/449 (24%), Positives = 216/449 (48%), Gaps = 59/449 (13%)

Query: 39   RIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAV--QGFIINIEE 96
            R RR  +K    L   +  +R R +A+  Q  +  + +   R R ++    Q +   +EE
Sbjct: 822  RQRREREKELQFLEEEEQLQR-RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEE 880

Query: 97   RRNKLRELL----ALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEK 152
             R + R  L    AL+E +   E QL +E  EE +   REK +  +++ +   ++ + ++
Sbjct: 881  ERKRRRHTLYAKPALQE-QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQE 939

Query: 153  LDQQFRERCEELRVELLS--IHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRL 210
             +Q  RE  E+ R +       + K  ++++ Q+   E   R++   E+ +    EE+ L
Sbjct: 940  EEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR---EEEEL 996

Query: 211  AKEK----REAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEE-EARLVESNNAQ 265
             +E+    RE +E RR++E     R          + Q++  QLL+EE E R ++    Q
Sbjct: 997  QQEEEQLLREEREKRRRQEWERQYR-------KKDELQQEEEQLLREEREKRRLQERERQ 1049

Query: 266  IKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEA 325
             + E E    ++Q   +E  T        R + ++++YR E++L     Q   Q L+EE 
Sbjct: 1050 YREEEELQQEEEQLLGEERET-------RRRQELERQYRKEEELQ----QEEEQLLREEP 1098

Query: 326  DKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEA 385
            +K++++  +             Q REEE+ Q++E   + EE + ++  E +++ R E+E 
Sbjct: 1099 EKRRRQERE------------RQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEV 1146

Query: 386  RRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQ 445
            +++         +L  +E  +R  +E E +  E++ + +  ++L  EE+E   RRQ   +
Sbjct: 1147 QQE-------EEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEK--RRQERER 1197

Query: 446  EYRKQLQMQIAYQQQSQEAEKEEKRREFE 474
            +YR++ ++Q   Q++ Q    E++R + +
Sbjct: 1198 QYREEEELQ--RQKRKQRYRDEDQRSDLK 1224



 Score =  101 bits (252), Expect = 1e-21
 Identities = 100/444 (22%), Positives = 219/444 (49%), Gaps = 48/444 (10%)

Query: 54   IKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYF 113
            ++  ER+R   + +Q   C+  +  +R   +D  + F    ++   + R+    EE +  
Sbjct: 1383 LRRQERERKFLKEEQQLRCQEREQQLR---QDRDRKFREEEQQLSRQERDRKFREEEQQV 1439

Query: 114  TEMQLKKETIEEKKDRMREKTKLLKEKN----EKERQDFVAEKLDQQFRERCEELRVELL 169
               + +++ +EE++   +E+ +  +E+     E+E Q    ++ D++F E  ++LR    
Sbjct: 1440 RRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLR---- 1495

Query: 170  SIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSK-------LWEEDRLAKEKREAQEAR- 221
               Q++  + R+ ++  ++E  R+ L EEQ   +       L EE +L +++R  Q  + 
Sbjct: 1496 --RQERDRKFREQELR-SQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD 1552

Query: 222  RQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAK 281
            R ++  E  +L    +   +  Q +  +   EE+   V     + K   ++  L++Q+ +
Sbjct: 1553 RDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK--VRRQEQERKFMEDEQQLRRQEGQ 1610

Query: 282  QETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKI 341
            Q+ R    +  +E  + +Q+  R+EQ L+ +  +R  + L+EE   ++Q+RE  +R  + 
Sbjct: 1611 QQLRQERDRKFREDEQLLQE--REEQQLHRQ--ERDRKFLEEEPQLRRQEREQQLRHDRD 1666

Query: 342  YHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQV 401
              K+   R EE+  QE E  ++  +++ +K  E++++LR ++  R+ L +E    R    
Sbjct: 1667 -RKF---REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRR---- 1718

Query: 402  QEKLQREAKEQEE--RAMEQKHINESLK--------ELNCEEKENFARRQRLAQEYRKQL 451
             ++L+R+ +E+E+  +  EQ+ +    +        +L  E +E   RRQ   +++R++ 
Sbjct: 1719 -QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEE 1777

Query: 452  QM-QIAYQQQSQEAEKEEKRREFE 474
            Q+ Q   +QQ +  E + K RE E
Sbjct: 1778 QLRQEREEQQLRSQESDRKFREEE 1801



 Score =  101 bits (251), Expect = 2e-21
 Identities = 94/373 (25%), Positives = 195/373 (52%), Gaps = 24/373 (6%)

Query: 124 EEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQ 183
           EEK+ R   K  LL+++ ++E Q    E  D+Q  E   + R       QK+  +E++ +
Sbjct: 97  EEKRARCDGKESLLQDRRQEEDQRRF-EPRDRQLEEEPGQRR------RQKR--QEQERE 147

Query: 184 IAFNEELSRQKLVEEQMFSKLWEED--RLAKEKREAQEARRQKELMENTRLGLNAQITSI 241
           +A  EE S ++   EQ   +  +E+  R  +E +E +E R ++E +++ + G   +    
Sbjct: 148 LAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK-GHETEEFPD 206

Query: 242 KAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETR---TILQKALQERIEH 298
           + Q +  +LL   E R       Q +    QD + +++ ++E R   T+L+K  ++  E 
Sbjct: 207 EEQLRRRELL---ELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEE 263

Query: 299 IQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREE-EKAQE 357
             Q  R+ Q+   +L +   Q+L+ E  +++Q+++ + REQ++  K   +RRE+ E+ +E
Sbjct: 264 EPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERRE 323

Query: 358 KEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAM 417
           ++  R  +E++ ++   +++E R E++ RR+  +E    R+ Q++ + + E +EQ+ R  
Sbjct: 324 QQERREQQEERREQQLRREQEERREQQLRREQEEE---RREQQLRREQEEERREQQLRRE 380

Query: 418 EQKHINESLK-ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAG 476
           +Q    + L+ E     ++   R Q+L +E + + + Q+  +QQ +  E+EE+R E +  
Sbjct: 381 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR-EQEEERHEQKHE 439

Query: 477 VAANKMCLDKVQE 489
               +  L + QE
Sbjct: 440 QERREQRLKREQE 452



 Score = 99.4 bits (246), Expect = 7e-21
 Identities = 100/480 (20%), Positives = 221/480 (46%), Gaps = 70/480 (14%)

Query: 23   VRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRAR 82
            VR +  + +  E   +  +  H+K       ++  E  +L     Q  D K L+   + R
Sbjct: 1439 VRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHR---QERDRKFLEEEQQLR 1495

Query: 83   IKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNE 142
             ++  + F    +E R++  E   LEE +     Q +++ ++E++   R+      E+ +
Sbjct: 1496 RQERDRKF--REQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQ------ERGQ 1547

Query: 143  KERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS 202
            + RQD      D++FRE  E+LR            +ER+ Q    +E  R+  +EEQ   
Sbjct: 1548 QRRQD-----RDRKFREE-EQLR------------QEREEQQLSRQERDRKFRLEEQKVR 1589

Query: 203  KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESN 262
            +  +E +  +++++ +    Q++L +             +  R+  QLL+E E + +   
Sbjct: 1590 RQEQERKFMEDEQQLRRQEGQQQLRQERD----------RKFREDEQLLQEREEQQLHRQ 1639

Query: 263  NAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDE---QDLNMKLVQRALQ 319
                K   E+  L++Q+ +Q+ R    +  +E  + +Q+    +   Q+ + K  +   Q
Sbjct: 1640 ERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQ 1699

Query: 320  DLQEEADKKKQKREDMIREQKIYHKY-----LAQRREEEKAQEKE-FDRILEEDKAK--- 370
              ++E ++K  + E  +R Q++  K+     L Q  E+E+ + +E + +ILEE++ +   
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759

Query: 371  -----KLAEKDKELRLEKEARRQLVDEVM----CTRKLQVQEKLQREAKEQEERAM---- 417
                 +  E+D++ R E++ R++  ++ +      RK + +E+L++E +EQ+ R      
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819

Query: 418  ------EQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRR 471
                  EQ  + E  + L  E    +   ++ A + + + + Q  +Q++ Q+  +E +R+
Sbjct: 1820 KYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERK 1879



 Score = 99.0 bits (245), Expect = 9e-21
 Identities = 117/465 (25%), Positives = 219/465 (47%), Gaps = 74/465 (15%)

Query: 24  RSKPPKGQGAEHHLERIRRSHQKHNAILAS--IKSSERDRLKAEWDQHNDCKILDSLVRA 81
           R +P   Q  E   +R R+  Q+    LA    +S +++RL+    Q  D    + L R 
Sbjct: 121 RFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRD----EELWRQ 176

Query: 82  RIKDAVQGFIINIEERRNKLRELLAL---EENEYFTEMQLKKETIEEKKDRMREKTKLLK 138
           R +   +      EERR +  +L +    E  E+  E QL++  + E + + RE+    K
Sbjct: 177 RQEWQER------EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREE----K 226

Query: 139 EKNEKERQDFV-AEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVE 197
           ++  +ERQD V  E+ ++++R+R   LR E           E K Q    EE  RQ+ ++
Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKE-----------EEKLQ---EEEPQRQRELQ 272

Query: 198 EQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEAR 257
           E       EE++L K +R+     RQ+E  +  RL    Q+   + + +  Q   +EE R
Sbjct: 273 E-------EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ---QEERR 322

Query: 258 LVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHI---QQEYRDEQDLNMKLV 314
             +    Q +   EQ + ++Q+ ++E +   ++  + R + +   Q+E R EQ L  +  
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382

Query: 315 QRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAE 374
            R  Q L+ E   ++ +RE  +R ++   +    RRE++  +E++  R  EE++ ++  E
Sbjct: 383 LRREQQLRRE---QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439

Query: 375 KDKE---LRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNC 431
           +++    L+ E+E RR  +     T + + + + Q+  ++QEE   E        + L  
Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE--------RWLKL 491

Query: 432 EEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEE--KRREFE 474
           EE+E   +++R  Q+ R++           QE  +E+  KR+E E
Sbjct: 492 EEEERREQQERREQQLRRE-----------QEERREQRLKRQEEE 525



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 98/447 (21%), Positives = 220/447 (49%), Gaps = 43/447 (9%)

Query: 39   RIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERR 98
            R R+S Q    +L   +  +R++ +  W Q +              +  Q  +   E++ 
Sbjct: 1259 RDRQSQQDLQHLLGEQQERDREQERRRWQQRD----------RHFPEEEQ--LEREEQKE 1306

Query: 99   NKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFR 158
             K R+  + EE +   E + +K   +E   + RE+ +LL+E+ E   Q    ++ D++FR
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE---QPLRRQERDRKFR 1363

Query: 159  ERCEELRVELLSIHQ---KKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEK- 214
            E  EELR      HQ   +K  EE   Q    +E  R+ L EEQ       E +L +++ 
Sbjct: 1364 E--EELR------HQEQGRKFLEEE--QRLRRQERERKFLKEEQQLRCQEREQQLRQDRD 1413

Query: 215  REAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDM 274
            R+ +E  +Q    E  R     +   ++ Q +  + L+EE+    E +    K   E+ +
Sbjct: 1414 RKFREEEQQLSRQERDRK-FREEEQQVRRQERERKFLEEEQQLRQERHR---KFREEEQL 1469

Query: 275  LKKQKAKQETRTILQKALQERIEHIQQEYRD----EQDLNMKLVQRALQDLQEEADKKKQ 330
            L++++ +Q  R    +   E  + ++++ RD    EQ+L  +  +R   + +++  ++++
Sbjct: 1470 LQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQR 1529

Query: 331  KREDMIREQKIYHKYLAQRREEEKAQE-KEFDRILEEDKAKKLA--EKDKELRLEKEARR 387
            +R+ +  EQ++  +   Q+R +++ ++ +E +++ +E + ++L+  E+D++ RLE++  R
Sbjct: 1530 QRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVR 1589

Query: 388  QLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEY 447
            +   E    + ++ +++L+R+  +Q+ R    +   E  + L   E++   R++R  +  
Sbjct: 1590 RQEQE---RKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFL 1646

Query: 448  RKQLQMQIAYQQQSQEAEKEEKRREFE 474
             ++ Q++   ++Q    +++ K RE E
Sbjct: 1647 EEEPQLRRQEREQQLRHDRDRKFREEE 1673



 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 93/406 (22%), Positives = 199/406 (49%), Gaps = 52/406 (12%)

Query: 94   IEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKL 153
            + E R K R              Q  +    E+++  +E+ +LL+E+ EK R+    ++L
Sbjct: 1124 LREEREKRRR-------------QELERQYREEEEVQQEEEQLLREEPEKRRR----QEL 1166

Query: 154  DQQFRERCEELRVE---LLSIHQKKVCEERKAQIAFNEELSRQKLV-----EEQMFSKLW 205
            ++Q+RE  EEL+ E   LL   Q+K  +ER+ Q    EEL RQK       E+Q     W
Sbjct: 1167 ERQYREE-EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKW 1225

Query: 206  ----EEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLL-------KEE 254
                E++   ++ +   + R  ++  +      ++Q+   ++Q+    LL       +E+
Sbjct: 1226 QWEPEKENAVRDNKVYCKGRENEQFRQLE----DSQLRDRQSQQDLQHLLGEQQERDREQ 1281

Query: 255  EARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLV 314
            E R  +  +     E + +  ++++AK+  R   ++    R E  ++  R E D   +  
Sbjct: 1282 ERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREE 1341

Query: 315  QRALQDLQEEADKKKQKREDMIREQKIYHKYLAQR--REEEKAQEKEFDR-ILEEDKAKK 371
            ++ LQ+ +EE   ++Q+R+   RE+++ H+   ++   EE++ + +E +R  L+E++  +
Sbjct: 1342 EQLLQE-REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLR 1400

Query: 372  LAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNC 431
              E++++LR +++ R+   +E   +R  Q +++  RE ++Q  R   ++   E  ++L  
Sbjct: 1401 CQEREQQLRQDRD-RKFREEEQQLSR--QERDRKFREEEQQVRRQERERKFLEEEQQLRQ 1457

Query: 432  EEKENFARRQRLAQEYRKQ----LQMQIAYQQQSQEAEKEEKRREF 473
            E    F   ++L QE  +Q     +    + ++ Q+  ++E+ R+F
Sbjct: 1458 ERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKF 1503



 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 100/453 (22%), Positives = 213/453 (47%), Gaps = 49/453 (10%)

Query: 34   EHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRA---RIKDAVQGF 90
            E  L + R   Q H          ERDR   E +Q    +  D   R    R ++  + F
Sbjct: 1466 EEQLLQEREEQQLHR--------QERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKF 1517

Query: 91   IINIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVA 150
            +   ++   + R+   L+E +     +  ++  +++  + RE+ +L   + E+E Q    
Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL---RQEREEQQLSR 1574

Query: 151  EKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRL 210
            ++ D++FR   +++R +     Q++   E + Q+   E    Q+ + ++   K  E+++L
Sbjct: 1575 QERDRKFRLEEQKVRRQ----EQERKFMEDEQQLRRQEG---QQQLRQERDRKFREDEQL 1627

Query: 211  AKEKREAQEARRQKE---LMENTRLGLNAQITSIKAQR-----QATQLLKEEEARLVESN 262
             +E+ E Q  R++++   L E  +L    +   ++  R     +  QLL+E E + +   
Sbjct: 1628 LQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQ 1687

Query: 263  NAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQ--- 319
                K   E+  L++Q+ +   R  LQ+  Q R + +++++R+E+ L  +  Q  L+   
Sbjct: 1688 ERDRKFREEEQQLRRQERE---RKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE 1744

Query: 320  ---DLQEEADKKKQKREDMIREQKIYHKY-----LAQRREEEKAQEKEFDRILEEDKAKK 371
                + EE   + ++ E  +R Q+   K+     L Q REE++ + +E DR   E++  +
Sbjct: 1745 RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLR 1804

Query: 372  LAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNC 431
               ++++LR ++   +   +E     +L+ QE+  R+ ++++ RA EQ    E  +    
Sbjct: 1805 QEREEQQLRPQQRDGKYRWEEEQL--QLEEQEQRLRQERDRQYRAEEQFATQEKSRR--- 1859

Query: 432  EEKENF-ARRQRLAQEYRKQLQMQIAYQQQSQE 463
            EE+E +    Q+  QE  ++L+ +   +QQ +E
Sbjct: 1860 EEQELWQEEEQKRRQERERKLREEHIRRQQKEE 1892



 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 103/417 (24%), Positives = 206/417 (49%), Gaps = 45/417 (10%)

Query: 96   ERRNKLRELLALEENEYFTEMQLKKETIE------EKKDRMREKTKLLKEKNEKERQDFV 149
            ER+ +  E L  EE +   E   K+   E      E+++  +E+ +LL+E+ EK R+   
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR--- 1133

Query: 150  AEKLDQQFRERCEELRVE----LLSIHQKKVCEERKAQIAFNEELSRQK---LVEEQMFS 202
             ++L++Q+RE  EE++ E    L    +K+  +E + Q    EEL +++   L EEQ   
Sbjct: 1134 -QELERQYREE-EEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKR 1191

Query: 203  KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIK--AQRQATQLLK-EEEARLV 259
            +   E +  +E+   ++ R+Q+   E+ R  L  Q    K  A R      K  E  +  
Sbjct: 1192 RQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFR 1251

Query: 260  ESNNAQIKHENEQDMLKKQKAKQETRTILQ--KALQERIEHIQQEYRDEQDLNMKLVQRA 317
            +  ++Q++    Q  L+    +Q+ R   Q  +  Q+R  H  +E + E++   K  +R 
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLERE-EQKEAKRR 1310

Query: 318  LQDLQEEADKKKQKREDMIREQKIYHKY-----LAQRREEEKAQEKEFDR------ILEE 366
             +  QEE    +++RE+  R Q+   K+     L Q REE+  + +E DR      +  +
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370

Query: 367  DKAKKLAEKDKELRLEKEARRQLVDE--VMC-TRKLQVQEKLQREAKEQEERAMEQ---K 420
            ++ +K  E+++ LR ++  R+ L +E  + C  R+ Q+++   R+ +E+E++   Q   +
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR 1430

Query: 421  HINESLKELNCEEKEN--FARRQRLAQEYRKQL--QMQIAYQQQSQEAEKEEKRREF 473
               E  +++  +E+E       Q+L QE  ++   + Q+  +++ Q+  ++E+ R+F
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKF 1487



 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 100/420 (23%), Positives = 209/420 (49%), Gaps = 51/420 (12%)

Query: 95   EERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLD 154
            EE   +  E L  EE E     +L+++  EE++ +  E+ +LL+E+ EK R+    ++L+
Sbjct: 1113 EEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEE-QLLREEPEKRRR----QELE 1167

Query: 155  QQFRERCEELRVE---LLSIHQKKVCEERKAQIAFNEELSRQKLV-----EEQMFSKLW- 205
            +Q+RE  EEL+ E   LL   Q+K  +ER+ Q    EEL RQK       E+Q     W 
Sbjct: 1168 RQYREE-EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQ 1226

Query: 206  ---EEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLL-------KEEE 255
               E++   ++ +   + R  ++  +      ++Q+   ++Q+    LL       +E+E
Sbjct: 1227 WEPEKENAVRDNKVYCKGRENEQFRQLE----DSQLRDRQSQQDLQHLLGEQQERDREQE 1282

Query: 256  ARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQ 315
             R  +  +     E + +  ++++AK+  R   ++    R E  ++  R E D   +  +
Sbjct: 1283 RRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEE 1342

Query: 316  RALQDLQEEADKKKQKREDMIREQKIYHKYLAQR--REEEKAQEKEFDR-ILEEDKAKKL 372
            + LQ+ +EE   ++Q+R+   RE+++ H+   ++   EE++ + +E +R  L+E++  + 
Sbjct: 1343 QLLQE-REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRC 1401

Query: 373  AEKDKELRLEKEAR---------RQLVDEVMCTRKLQVQ-EKLQREAKEQEERAMEQKH- 421
             E++++LR +++ +         RQ  D      + QV+ ++ +R+  E+E++  +++H 
Sbjct: 1402 QEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHR 1461

Query: 422  -INESLKELNCEEKENFARRQR------LAQEYRKQLQMQIAYQQQSQEAEKEEKRREFE 474
               E  + L   E++   R++R        Q+ R+Q + +   +Q+ +  E E K  E E
Sbjct: 1462 KFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEE 1521



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 71/285 (24%), Positives = 139/285 (48%), Gaps = 32/285 (11%)

Query: 102  RELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERC 161
            R+   LEE       + +++   ++  + RE+ +LL+E  E++ +    ++ D++FRE  
Sbjct: 1641 RDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLR---RQERDRKFREEE 1697

Query: 162  EELRV---ELLSIHQKKVCEERKAQIAFNEELS-RQKLVEEQM-----FSKLWEEDRLAK 212
            ++LR    E   + +++    ++ +  F EE   RQ+  +EQ+     + K+ EE++L  
Sbjct: 1698 QQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRP 1757

Query: 213  EKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQ 272
            E+ E Q  R++++               ++ +R+  QL  +E  R       Q++ E E+
Sbjct: 1758 EREEQQLRRQERDRKFREE-------EQLRQEREEQQLRSQESDRKFREEE-QLRQEREE 1809

Query: 273  DMLKKQKAKQETR-TILQKALQERIEHIQQE----YR-DEQDLNMKLVQRALQDL-QEEA 325
              L+ Q+   + R    Q  L+E+ + ++QE    YR +EQ    +  +R  Q+L QEE 
Sbjct: 1810 QQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEE 1869

Query: 326  DKKKQKRE-----DMIREQKIYHKYLAQRREEEKAQEKEFDRILE 365
             K++Q+RE     + IR Q+   +   Q  E +  + K   R+LE
Sbjct: 1870 QKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914



 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 61/265 (23%), Positives = 122/265 (46%), Gaps = 20/265 (7%)

Query: 225 ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQET 284
           +L  N R+  N  +  I    QA      +   L E   A+   + ++ +L+ ++ +++ 
Sbjct: 62  DLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARC--DGKESLLQDRRQEEDQ 119

Query: 285 RTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEA--DKKKQKREDMIREQKIY 342
           R    +  Q   E  Q+  +  Q+   +L +   Q  ++E    + +Q+R++ +  Q+  
Sbjct: 120 RRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQE 179

Query: 343 HKYLAQRREEE------KAQEKEFDRILEEDKAKKLAEKDKELRLEK-EARRQLVDEVMC 395
            +   +RR EE      K  E E     E+ + ++L E  ++ R EK + RR+  D V  
Sbjct: 180 WQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQ 239

Query: 396 TRKLQVQEKLQ-----REAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQ 450
             + +   K +      E K QEE    Q+ + E  ++L   E++   RR+R  +E ++Q
Sbjct: 240 EEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL-RRERQEEEQQQQ 298

Query: 451 ---LQMQIAYQQQSQEAEKEEKRRE 472
               + Q+  +Q+ +  E++E+RRE
Sbjct: 299 RLRREQQLRRKQEEERREQQEERRE 323


>gi|219803769 trichoplein [Homo sapiens]
          Length = 498

 Score =  129 bits (325), Expect = 5e-30
 Identities = 99/420 (23%), Positives = 213/420 (50%), Gaps = 15/420 (3%)

Query: 63  KAEWDQHNDC-KILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKE 121
           +AEW       + + +  R ++K+  +    ++E RR KLR+L+  E++    E++  + 
Sbjct: 51  QAEWSSKTSYQRSMHAYQREKMKEEKRR---SLEARREKLRQLMQEEQDLLARELEELRL 107

Query: 122 TIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERK 181
           ++  ++ R+RE+   LK   E++R+    + L + +++   +LR   L +HQK V    +
Sbjct: 108 SMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWE 167

Query: 182 AQIAFNEELSRQKLVEEQMFSKLWEED-----RLAKEKREAQEARRQKELMENTRLGLNA 236
            Q    EE  +Q+   EQ  +K +E +     R A E+ +A+E RRQ E        L  
Sbjct: 168 MQ---KEEKKQQEATAEQE-NKRYENEYERARREALERMKAEEERRQLEDKLQAE-ALLQ 222

Query: 237 QITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERI 296
           Q+  +K +      LK+E+  L++      + E E+  ++  + K E    L+     ++
Sbjct: 223 QMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQL 282

Query: 297 EHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQ 356
               Q+ ++E + + +++Q  L+   E       +RE ++ +     + + ++ + E+A+
Sbjct: 283 SRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAR 342

Query: 357 EKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERA 416
           E E   +L E+  +   +++ E   E+ AR +L+ EV+  R+ Q+QEK+++  + QEE  
Sbjct: 343 EAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL 402

Query: 417 MEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQ-QSQEAEKEEKRREFEA 475
             ++ +  +L+E+    +      ++L    +++L+ Q+A ++ Q+ EA+++E+  E EA
Sbjct: 403 KHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA 462



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 98/420 (23%), Positives = 206/420 (49%), Gaps = 40/420 (9%)

Query: 38  ERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEER 97
           E  RRS +     L  +   E+D L  E ++    ++  +L   RI++         EE+
Sbjct: 74  EEKRRSLEARREKLRQLMQEEQDLLARELEE---LRLSMNLQERRIREQHGKLKSAKEEQ 130

Query: 98  RNKLRELLALEE----NEYFTEMQL---KKETI---EEKKDRMREKTKLLKEKNEKERQD 147
           R  + E L  E     N    EM+L   +K  +   E +K+  +++    +++N++   +
Sbjct: 131 RKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENE 190

Query: 148 FVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNE-ELSRQKLVEEQMFSKLWE 206
           +   + +   R + EE R +L    Q +   ++  ++   E E ++ K  +E +  + WE
Sbjct: 191 YERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250

Query: 207 EDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEA--RLVESNNA 264
            +RL +E+++ +  R++ EL    R   NAQ++     R+  Q+ +E EA  R+++   A
Sbjct: 251 LERLEEERKQMEAFRQKAELGRFLRHQYNAQLS-----RRTQQIQEELEADRRILQ---A 302

Query: 265 QIKHENEQDMLKKQKAKQETRTI--LQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQ 322
            ++ E+E   L   + +Q    +  +++A++E++   Q E   E +L M L + A +  +
Sbjct: 303 LLEKEDESQRLHLARREQVMADVAWMKQAIEEQL---QLERAREAELQMLLREEAKEMWE 359

Query: 323 E---EADKKKQKREDMI------REQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
           +   E  +++  R+ ++      R+Q+I  K    RR +E++ +     I   ++ ++LA
Sbjct: 360 KREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELA 419

Query: 374 EKDKELRLE-KEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCE 432
            ++KE   + K AR+Q ++  +  R+LQ  E  Q+E +E+EE A   + ++++L +   E
Sbjct: 420 RREKEESEKLKSARKQELEAQVAERRLQAWEADQQE-EEEEEEARRVEQLSDALLQQEAE 478



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 95/407 (23%), Positives = 185/407 (45%), Gaps = 72/407 (17%)

Query: 151 EKLDQQF-RERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDR 209
           ++L+QQ  R+R +E R+        +    R + I  +++         Q     ++ ++
Sbjct: 14  QRLNQQLARQREQEARLRQQWEQNSRYF--RMSDICSSKQAEWSSKTSYQRSMHAYQREK 71

Query: 210 LAKEKREAQEARRQK--ELM-----------ENTRLGLNAQITSIKAQRQATQLLKEEEA 256
           + +EKR + EARR+K  +LM           E  RL +N Q   I+ Q    +  KEE+ 
Sbjct: 72  MKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQR 131

Query: 257 RLV---------ESNNAQIK------HE----NEQDMLKKQKAKQET---------RTIL 288
           +L+         + NN +++      H+    N  +M K++K +QE              
Sbjct: 132 KLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEY 191

Query: 289 QKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE------EADKKKQKREDMIREQKIY 342
           ++A +E +E ++ E    Q  +    +  LQ ++E      EA K K+++E++++++   
Sbjct: 192 ERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWEL 251

Query: 343 HKYLAQRREEEKAQEK-EFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVM------- 394
            +   +R++ E  ++K E  R L      +L+ + ++++ E EA R+++  ++       
Sbjct: 252 ERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQ 311

Query: 395 ---CTRKLQVQE-----KLQREAKEQEERAME---QKHINESLKELNCEEKENFARRQRL 443
                R+ QV       K   E + Q ERA E   Q  + E  KE+  E++E    R+R 
Sbjct: 312 RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEM-WEKREAEWARERS 370

Query: 444 AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEV 490
           A++ R   ++    QQQ QE + E+ RR  E  +   +  +  ++EV
Sbjct: 371 ARD-RLMSEVLTGRQQQIQE-KIEQNRRAQEESLKHREQLIRNLEEV 415


>gi|14150056 trichoplein [Homo sapiens]
          Length = 498

 Score =  129 bits (325), Expect = 5e-30
 Identities = 99/420 (23%), Positives = 213/420 (50%), Gaps = 15/420 (3%)

Query: 63  KAEWDQHNDC-KILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKE 121
           +AEW       + + +  R ++K+  +    ++E RR KLR+L+  E++    E++  + 
Sbjct: 51  QAEWSSKTSYQRSMHAYQREKMKEEKRR---SLEARREKLRQLMQEEQDLLARELEELRL 107

Query: 122 TIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERK 181
           ++  ++ R+RE+   LK   E++R+    + L + +++   +LR   L +HQK V    +
Sbjct: 108 SMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWE 167

Query: 182 AQIAFNEELSRQKLVEEQMFSKLWEED-----RLAKEKREAQEARRQKELMENTRLGLNA 236
            Q    EE  +Q+   EQ  +K +E +     R A E+ +A+E RRQ E        L  
Sbjct: 168 MQ---KEEKKQQEATAEQE-NKRYENEYERARREALERMKAEEERRQLEDKLQAE-ALLQ 222

Query: 237 QITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERI 296
           Q+  +K +      LK+E+  L++      + E E+  ++  + K E    L+     ++
Sbjct: 223 QMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQL 282

Query: 297 EHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQ 356
               Q+ ++E + + +++Q  L+   E       +RE ++ +     + + ++ + E+A+
Sbjct: 283 SRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAR 342

Query: 357 EKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERA 416
           E E   +L E+  +   +++ E   E+ AR +L+ EV+  R+ Q+QEK+++  + QEE  
Sbjct: 343 EAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL 402

Query: 417 MEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQ-QSQEAEKEEKRREFEA 475
             ++ +  +L+E+    +      ++L    +++L+ Q+A ++ Q+ EA+++E+  E EA
Sbjct: 403 KHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA 462



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 98/420 (23%), Positives = 206/420 (49%), Gaps = 40/420 (9%)

Query: 38  ERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEER 97
           E  RRS +     L  +   E+D L  E ++    ++  +L   RI++         EE+
Sbjct: 74  EEKRRSLEARREKLRQLMQEEQDLLARELEE---LRLSMNLQERRIREQHGKLKSAKEEQ 130

Query: 98  RNKLRELLALEE----NEYFTEMQL---KKETI---EEKKDRMREKTKLLKEKNEKERQD 147
           R  + E L  E     N    EM+L   +K  +   E +K+  +++    +++N++   +
Sbjct: 131 RKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENE 190

Query: 148 FVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNE-ELSRQKLVEEQMFSKLWE 206
           +   + +   R + EE R +L    Q +   ++  ++   E E ++ K  +E +  + WE
Sbjct: 191 YERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250

Query: 207 EDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEA--RLVESNNA 264
            +RL +E+++ +  R++ EL    R   NAQ++     R+  Q+ +E EA  R+++   A
Sbjct: 251 LERLEEERKQMEAFRQKAELGRFLRHQYNAQLS-----RRTQQIQEELEADRRILQ---A 302

Query: 265 QIKHENEQDMLKKQKAKQETRTI--LQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQ 322
            ++ E+E   L   + +Q    +  +++A++E++   Q E   E +L M L + A +  +
Sbjct: 303 LLEKEDESQRLHLARREQVMADVAWMKQAIEEQL---QLERAREAELQMLLREEAKEMWE 359

Query: 323 E---EADKKKQKREDMI------REQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
           +   E  +++  R+ ++      R+Q+I  K    RR +E++ +     I   ++ ++LA
Sbjct: 360 KREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELA 419

Query: 374 EKDKELRLE-KEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCE 432
            ++KE   + K AR+Q ++  +  R+LQ  E  Q+E +E+EE A   + ++++L +   E
Sbjct: 420 RREKEESEKLKSARKQELEAQVAERRLQAWEADQQE-EEEEEEARRVEQLSDALLQQEAE 478



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 95/407 (23%), Positives = 185/407 (45%), Gaps = 72/407 (17%)

Query: 151 EKLDQQF-RERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDR 209
           ++L+QQ  R+R +E R+        +    R + I  +++         Q     ++ ++
Sbjct: 14  QRLNQQLARQREQEARLRQQWEQNSRYF--RMSDICSSKQAEWSSKTSYQRSMHAYQREK 71

Query: 210 LAKEKREAQEARRQK--ELM-----------ENTRLGLNAQITSIKAQRQATQLLKEEEA 256
           + +EKR + EARR+K  +LM           E  RL +N Q   I+ Q    +  KEE+ 
Sbjct: 72  MKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQR 131

Query: 257 RLV---------ESNNAQIK------HE----NEQDMLKKQKAKQET---------RTIL 288
           +L+         + NN +++      H+    N  +M K++K +QE              
Sbjct: 132 KLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEY 191

Query: 289 QKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE------EADKKKQKREDMIREQKIY 342
           ++A +E +E ++ E    Q  +    +  LQ ++E      EA K K+++E++++++   
Sbjct: 192 ERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWEL 251

Query: 343 HKYLAQRREEEKAQEK-EFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVM------- 394
            +   +R++ E  ++K E  R L      +L+ + ++++ E EA R+++  ++       
Sbjct: 252 ERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQ 311

Query: 395 ---CTRKLQVQE-----KLQREAKEQEERAME---QKHINESLKELNCEEKENFARRQRL 443
                R+ QV       K   E + Q ERA E   Q  + E  KE+  E++E    R+R 
Sbjct: 312 RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEM-WEKREAEWARERS 370

Query: 444 AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEV 490
           A++ R   ++    QQQ QE + E+ RR  E  +   +  +  ++EV
Sbjct: 371 ARD-RLMSEVLTGRQQQIQE-KIEQNRRAQEESLKHREQLIRNLEEV 415


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score =  107 bits (266), Expect = 3e-23
 Identities = 97/399 (24%), Positives = 207/399 (51%), Gaps = 45/399 (11%)

Query: 82  RIKDAVQGFIINIEERRNKLRELLALEEN--EYFTEMQLKKETIEEKKDRMREKTKLLKE 139
           R ++ +Q +   I+E+  K+RE    EE   E   +M+ ++E + EK+++MR + +++ E
Sbjct: 304 RQEEKIQEWEEKIQEQEEKIREQ---EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360

Query: 140 KNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQ 199
           K EK R      +L++   E+ E++R     +H+++   E++ +    E++  Q+  +EQ
Sbjct: 361 KEEKMR------RLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 414

Query: 200 MFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSI-KAQRQATQLLKEEEARL 258
             +K+W ++   +E+ E    + +K   +  ++    +I    K Q Q     +EE+ R 
Sbjct: 415 E-AKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE 473

Query: 259 VESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRAL 318
            E    Q +  +EQ+ ++KQ+ K           QE   H Q+E   EQ+  M   +  +
Sbjct: 474 QEEIWRQKEKMHEQEKIRKQEEKVWR--------QEEKMHDQEEKIREQEEKMWRQEEKI 525

Query: 319 QDLQE---EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEK 375
           ++ +E   E ++K +++E+M++EQ+          +EEK QE+E  R  EE    K+ E+
Sbjct: 526 REQEEKIREQEEKIREQEEMMQEQEE-----KMGEQEEKMQEQEKMRRQEE----KIREQ 576

Query: 376 DKELRLEKEARRQLVDEVM-CTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEK 434
           ++++R +KE  R+  +++     K++ QE++ +E   QEE+  EQ       +E  CE++
Sbjct: 577 EEKIREQKEKIREQEEKIWEQEEKIREQEEMMQE---QEEKMWEQ-------EEKMCEQE 626

Query: 435 ENF-ARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRRE 472
           E    + +++ ++  K  + ++  +QQ ++ ++ ++  E
Sbjct: 627 EKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665



 Score =  103 bits (256), Expect = 5e-22
 Identities = 99/408 (24%), Positives = 219/408 (53%), Gaps = 50/408 (12%)

Query: 107 LEENEYFTEM-QLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELR 165
           +EENE +  + Q ++E +  ++++++E  + ++E+ EK R+       +++ RE+ E++R
Sbjct: 285 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ------EEKIREQEEKMR 338

Query: 166 VELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKE 225
            +   + +K+    R+ ++ + +E   ++L EE M+ K  E+ R  +EK   QE  R++E
Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRL-EEMMWEKE-EKIRELEEKMHEQEKIREQE 396

Query: 226 LMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETR 285
                             +RQ  + ++E+E R  +   A++  + E+   +++K +++ +
Sbjct: 397 -----------------EKRQEEEKIREQEKR--QEQEAKMWRQEEKIREQEEKIREQEK 437

Query: 286 TILQKALQERI---EHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQK--REDMIR--E 338
            + ++  +E+I   E I++E + ++   M   +  +++ QEE  ++K+K   ++ IR  E
Sbjct: 438 KMWRQ--EEKIHEQEKIREEEKRQEQEEMWRQEEKIRE-QEEIWRQKEKMHEQEKIRKQE 494

Query: 339 QKIYHKYLAQRREEEKAQEKEFDRILEEDKAK----KLAEKDKELRLEKEARRQLVDEVM 394
           +K++ +      +EEK +E+E     +E+K +    K+ E+++++R E+E   Q  +E M
Sbjct: 495 EKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIR-EQEEMMQEQEEKM 553

Query: 395 CTR--KLQVQEKLQRE---AKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRK 449
             +  K+Q QEK++R+    +EQEE+  EQK      +E   E++E    ++ + QE  +
Sbjct: 554 GEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEE 613

Query: 450 QL--QMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQ 495
           ++  Q +   +Q+ +  E+EEK R  E  +   ++ L + +E +  HQ
Sbjct: 614 KMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 661



 Score = 92.4 bits (228), Expect = 9e-19
 Identities = 87/401 (21%), Positives = 190/401 (47%), Gaps = 19/401 (4%)

Query: 92  INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAE 151
           +++E  RN + +    E+N    ++Q K + +E +K  ++   K LK K E+ +      
Sbjct: 205 LSLELYRNTITDEELKEKN---AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP-- 259

Query: 152 KLDQQFRERCEELRVELLSIHQKKVC--EERKAQIAFNEELSRQKLVEEQMFSKLWEEDR 209
              QQ +   + L  EL S+  K     EE +     N++   +   +E+   + WEE  
Sbjct: 260 --QQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE-WEEKI 316

Query: 210 LAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHE 269
             +E++  ++  + +E  E  R          +  R+  +++ E+E ++        + E
Sbjct: 317 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKE 376

Query: 270 NEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKK 329
            +   L+++  +QE     ++  QE  +  +QE R EQ+  M    R  + ++E+ +K +
Sbjct: 377 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM---WRQEEKIREQEEKIR 433

Query: 330 QKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQL 389
           ++ + M R+++  H+    R EE++ +++E  R  E+ + ++   + KE   E+E  R+ 
Sbjct: 434 EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQ 493

Query: 390 VDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRK 449
            ++V   R+ +     + + +EQEE+   Q+      +E   E++E    ++ + QE  +
Sbjct: 494 EEKVW--RQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEE 551

Query: 450 QL-QMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQE 489
           ++ + +   Q+Q +   +EEK RE E  +   K   +K++E
Sbjct: 552 KMGEQEEKMQEQEKMRRQEEKIREQEEKIREQK---EKIRE 589



 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 95/400 (23%), Positives = 199/400 (49%), Gaps = 32/400 (8%)

Query: 122 TIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERK 181
           T ++K DR  E+  L KE++    + +     D++ +E+  +L+ +L      ++ E  K
Sbjct: 186 TQKKKADRYIEE--LTKERDALSLELYRNTITDEELKEKNAKLQEKL------QLVESEK 237

Query: 182 AQIAFN-----EELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNA 236
           ++I  N      +L R KL+  Q   +  E D L KE +    A+ Q ++ EN       
Sbjct: 238 SEIQLNVKELKRKLERAKLLLPQQQLQA-EADHLGKELQSVS-AKLQAQVEENELWNRLN 295

Query: 237 QITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERI 296
           Q    K  RQ  ++ + EE   ++    +I+ + E+   +++K +++   + +K  +E++
Sbjct: 296 QQQEEKMWRQEEKIQEWEEK--IQEQEEKIREQEEKIREQEEKMRRQEEMMWEK--EEKM 351

Query: 297 EHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQK--REDMIREQKIYHKYLAQRREEEK 354
              Q+E   E++  M+ ++  + + +E+  + ++K   ++ IREQ+   +   + RE+EK
Sbjct: 352 RR-QEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 410

Query: 355 AQEKEFDRILEEDKAK----KLAEKDKEL-RLEKEARRQLVDEVMCTRKLQVQEKLQREA 409
            QE+E     +E+K +    K+ E++K++ R E++   Q  +++    K Q QE++ R+ 
Sbjct: 411 RQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ--EKIREEEKRQEQEEMWRQE 468

Query: 410 ---KEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEK 466
              +EQEE   +++ ++E  K    EEK      +   QE + + Q +  ++Q+ +  E+
Sbjct: 469 EKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQ 528

Query: 467 EEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNIHPMRK 506
           EEK RE E  +   +  + + +E +   +   Q    MR+
Sbjct: 529 EEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRR 568


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score =  105 bits (261), Expect = 1e-22
 Identities = 102/429 (23%), Positives = 220/429 (51%), Gaps = 44/429 (10%)

Query: 82  RIKDAVQGFIINIEERRNKLRELLALEEN--EYFTEMQLKKETIEEKKDRMREKTKLLKE 139
           R ++ +Q +   I+E+  K+RE    EE   E   +M+ ++E + EK+++MR + +++ E
Sbjct: 304 RQEEKIQEWEEKIQEQEEKIREQ---EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360

Query: 140 KNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIA-FNEELSRQKLVEE 198
           K EK R+       ++   E+ E++R       Q+++  E++ +I    E++  Q+ + E
Sbjct: 361 KEEKMRRQ------EEMMWEKEEKMR------RQEEMMWEKEEKIRELEEKMHEQEKIRE 408

Query: 199 QMFSKLWEEDRLAKEKREAQEAR--RQKELMENTRLGLNAQITSIKAQRQATQLLKEEEA 256
           Q   +  EE    +EKR+ QEA+  RQ+E +      +  Q    K  RQ  ++ ++E+ 
Sbjct: 409 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ--EKKMWRQEEKIHEQEKI 466

Query: 257 RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
           R  E      K + +++M ++++   E   I ++  +E++   +++ R +++     V R
Sbjct: 467 REEE------KRQEQEEMWRQEEKIHEQEEIWRQ--KEKMHEQEEKIRKQEEK----VWR 514

Query: 317 ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
             + ++E+ +K +++ E M R+++   +     REEEK  E+E  +I EE+K ++  ++D
Sbjct: 515 QEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQE--KIWEEEKRQE--QED 570

Query: 377 KELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKE----QEERAMEQKHINESLKELNCE 432
           K  R E++ R Q         K++ QE+ ++E +E    QEE+  EQ+   +  +E   E
Sbjct: 571 KMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIRE 630

Query: 433 EKENFARRQRLAQEYRKQL--QMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEV 490
           ++E    ++ + QE  +++  Q +   +Q+ +  E+EE     E  +   +  + + +E 
Sbjct: 631 QEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEK 690

Query: 491 LSTHQVLPQ 499
           +   + + Q
Sbjct: 691 IREQEEMMQ 699



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 109/480 (22%), Positives = 224/480 (46%), Gaps = 52/480 (10%)

Query: 55  KSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFT 114
           +  + DR   E  +  D   L+ L R  I D        ++E+  KL+E L L E+E  +
Sbjct: 187 QKKKADRYIEELTKERDALSLE-LYRNTITDE------ELKEKNAKLQEKLQLVESEK-S 238

Query: 115 EMQLKKETIEEKKDRMR---EKTKLLKEKNE--KERQDFVAEKLDQQFRE-----RCEEL 164
           E+QL  + ++ K +R +    + +L  E +   KE Q  V+ KL  Q  E     R  + 
Sbjct: 239 EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS-VSAKLQAQVEENELWNRLNQQ 297

Query: 165 RVELLSIHQKKVCE------ERKAQIAFNEELSRQKLVEEQMFSK---LWEEDRLAKEKR 215
           + E +   ++K+ E      E++ +I   EE  R++  EE+M  +   +WE++   + + 
Sbjct: 298 QEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ--EEKMRRQEEMMWEKEEKMRRQE 355

Query: 216 EA-----QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHEN 270
           E      ++ RRQ+E+M      +  Q   +  + +  + L EE+    E    Q +   
Sbjct: 356 EMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL-EEKMHEQEKIREQEEKRQ 414

Query: 271 EQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQ 330
           E++ +++Q+ +QE    + +  +E+I   +++ R+++    +  ++  +  +   ++K+Q
Sbjct: 415 EEEKIREQEKRQEQEAKMWRQ-EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQ 473

Query: 331 KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA-----------KKLAEKDKEL 379
           ++E+M R+++  H+     R++EK  E+E     +E+K            +K+ E+++++
Sbjct: 474 EQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKM 533

Query: 380 RLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEER----AMEQKHINESLKELNCEEKE 435
             ++E  R+  +      K+  QEK+  E K QE+       E+K   +  K    EEK 
Sbjct: 534 WRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKI 593

Query: 436 NFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQ 495
                +R  QE +   Q +   +Q+ +  E+EEK RE E  +   +    + +E +   +
Sbjct: 594 REQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQE 653


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score =  104 bits (259), Expect = 2e-22
 Identities = 95/405 (23%), Positives = 218/405 (53%), Gaps = 54/405 (13%)

Query: 82  RIKDAVQGFIINIEERRNKLRELLALEEN--EYFTEMQLKKETIEEKKDRMREKTKLLKE 139
           R ++ +Q +   I+E+  K+RE    EE   E   +M+ ++E + EK+++MR + +++ E
Sbjct: 365 RQEEKIQEWEEKIQEQEEKIREQ---EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 421

Query: 140 KNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQ 199
           K EK R+       ++   E+ E++R     +H+++   E++ +    E++  Q+  +EQ
Sbjct: 422 KEEKMRRQ------EEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 475

Query: 200 MFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLV 259
             +K+W ++   +E+ E  + R Q+E                K  RQ  ++ ++E+ R  
Sbjct: 476 E-AKMWRQEEKIREQEE--KIREQEE----------------KMWRQEEKIHEQEKIREE 516

Query: 260 ESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQ 319
           E      K + +++M ++++  +E   I ++  +E+I H Q+E   +Q+  M   +  + 
Sbjct: 517 E------KRQEQEEMWRQEEKIREQEEIWRQ--KEKI-HEQEEKIRKQEEKMWRQEEKMH 567

Query: 320 DLQE---EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
           D +E   E ++K  ++E+ IREQ+        R +EEK +E+E    + +++ +K+ E++
Sbjct: 568 DQEEKIREQEEKVWRQEEKIREQEE-----KIREQEEKIREQEE---MTQEQEEKMGEQE 619

Query: 377 KELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKEN 436
           +++  E+E + Q  +E M  ++ +++E+ +++ +EQEE+  EQ+ + +  +E   E++E 
Sbjct: 620 EKM-CEQEEKMQEQEEKMRRQEEKIREQ-EKKIREQEEKIREQEEMMQEQEEKMWEQEEK 677

Query: 437 FARRQRLAQEYRKQLQMQIA--YQQQSQEAEKEEKRREFEAGVAA 479
              ++   QE  ++++ Q    ++Q+ +  ++EEK +E +  + A
Sbjct: 678 MCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722



 Score =  101 bits (252), Expect = 1e-21
 Identities = 91/396 (22%), Positives = 209/396 (52%), Gaps = 31/396 (7%)

Query: 107 LEENEYFTEM-QLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELR 165
           +EENE +  + Q ++E +  ++++++E  + ++E+ EK R+       +++ RE+ E++R
Sbjct: 346 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ------EEKIREQEEKMR 399

Query: 166 VELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKE 225
            +   + +K+    R+ ++ + +E  + +  EE M+ K  E+ R  +EK   QE  R++E
Sbjct: 400 RQEEMMWEKEEKMRRQEEMMWEKE-EKMRRQEEMMWEKE-EKIRELEEKMHEQEKIREQE 457

Query: 226 LMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETR 285
                   +  Q    K Q Q  ++ ++EE   +     +I+ + E+   +++K  ++ +
Sbjct: 458 EKRQEEEKIREQE---KRQEQEAKMWRQEEK--IREQEEKIREQEEKMWRQEEKIHEQEK 512

Query: 286 TILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKY 345
              ++  QE+ E  +QE   E+    + + R  + + E+ +K +++ E M R+++  H  
Sbjct: 513 IREEEKRQEQEEMWRQE---EKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQ 569

Query: 346 LAQRREEEKAQEKEFDRILE-EDKAKKLAEK---DKELRLEKEARRQLVDEVMCTRKLQV 401
             + RE+E+   ++ ++I E E+K ++  EK    +E+  E+E +    +E MC ++ ++
Sbjct: 570 EEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKM 629

Query: 402 QEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQL--QMQIAYQQ 459
           QE+ + + + QEE+  EQ+      K++  E++E    ++ + QE  +++  Q +   +Q
Sbjct: 630 QEQ-EEKMRRQEEKIREQE------KKIR-EQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 681

Query: 460 QSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQ 495
           + +  E+EEK R  E  +   ++ L + +E +  HQ
Sbjct: 682 EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 717



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 86/412 (20%), Positives = 196/412 (47%), Gaps = 16/412 (3%)

Query: 92  INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAE 151
           +++E  RN + +    E+N    ++Q K + +E +K  ++   K LK K E+ +      
Sbjct: 266 LSLELYRNTITDEELKEKN---AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP-- 320

Query: 152 KLDQQFRERCEELRVELLSIHQKKVC--EERKAQIAFNEELSRQKLVEEQMFSKLWEEDR 209
              QQ +   + L  EL S+  K     EE +     N++   +   +E+   + WEE  
Sbjct: 321 --QQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE-WEEKI 377

Query: 210 LAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHE 269
             +E++  ++  + +E  E  R          +  R+  +++ E+E ++        + E
Sbjct: 378 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 437

Query: 270 NEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKK 329
            +   L+++  +QE     ++  QE  +  +QE R EQ+  M    R  + ++E+ +K +
Sbjct: 438 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM---WRQEEKIREQEEKIR 494

Query: 330 QKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQL 389
           ++ E M R+++  H+    R EE++ +++E  R  E+ + ++   + KE   E+E + + 
Sbjct: 495 EQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRK 554

Query: 390 VDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRK 449
            +E M  ++ ++ ++ + + +EQEE+   Q+      +E   E++E    ++ + QE  +
Sbjct: 555 QEEKMWRQEEKMHDQ-EEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEE 613

Query: 450 QL--QMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQ 499
           ++  Q +   +Q+ +  E+EEK R  E  +   +  + + +E +   + + Q
Sbjct: 614 KMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ 665



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 89/367 (24%), Positives = 176/367 (47%), Gaps = 54/367 (14%)

Query: 178 EERKAQIAFNEELSRQKLVEEQMF---SKLWEEDRLAK-EKREAQ-EARRQKELMENTRL 232
           E  K + A + EL R  + +E++    +KL E+ +L + EK E Q   +  K  +E  +L
Sbjct: 258 ELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKL 317

Query: 233 GLNAQITSIKAQRQATQLLKEEEARL---VESNNA--QIKHENEQDMLKKQKAKQETRTI 287
            L  Q    +A     +L +   A+L   VE N    ++  + E+ M ++++  QE    
Sbjct: 318 LLPQQQLQAEADHLGKEL-QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEW--- 373

Query: 288 LQKALQERIEHI--QQEYRDEQDLNMKLVQRALQDLQE----------EADKKKQKREDM 335
            ++ +QE+ E I  Q+E   EQ+  M+  +  + + +E          E ++K +++E+M
Sbjct: 374 -EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM 432

Query: 336 I--REQKI------YHKYLAQRREEEKAQEKEFDRILE---EDKAKKLAEKDKELRLEKE 384
           +  +E+KI       H+    R +EEK QE+E  R  E   E +AK   +++K    E++
Sbjct: 433 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 492

Query: 385 ARRQLVDEVMCTRKLQVQEKLQREAKEQEERAM---------------EQKHINESLKEL 429
            R Q         K+  QEK++ E K QE+  M               +++ I+E  +++
Sbjct: 493 IREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKI 552

Query: 430 NCEEKENFARRQRL-AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQ 488
             +E++ + + +++  QE + + Q +  ++Q+ +  E+EEK RE E  +   +    + +
Sbjct: 553 RKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQE 612

Query: 489 EVLSTHQ 495
           E +   +
Sbjct: 613 EKMGEQE 619



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 89/383 (23%), Positives = 183/383 (47%), Gaps = 46/383 (12%)

Query: 162 EELRVEL-LSIHQKKV--CEERKAQIAFNEELSRQKLVEEQ---MFSKLWEEDRLAKEKR 215
           E LR EL   +H  ++  C++ + Q+A        K +E +   + S+L +  + A E  
Sbjct: 180 EALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELE 239

Query: 216 EA--------QEARRQKELMENTRLGLNAQI---TSIKAQRQATQLLKEEEARLVESNNA 264
           +A        ++A R  E +   R  L+ ++   T    + +      +E+ +LVES  +
Sbjct: 240 QALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKS 299

Query: 265 QIKHENEQDMLKKQKAKQETRTIL--QKALQERIEHIQQEYRDEQDLNMKLVQRALQD-- 320
           +I     Q  +K+ K K E   +L  Q+ LQ   +H+ +E    Q ++ KL  +  ++  
Sbjct: 300 EI-----QLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL---QSVSAKLQAQVEENEL 351

Query: 321 ---LQEEADKKKQKREDMIRE--QKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEK 375
              L ++ ++K  ++E+ I+E  +KI  +    R +EEK +E+E     +E+   +  EK
Sbjct: 352 WNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEK 411

Query: 376 ---DKELRLEKEARRQLVDEVMCTRKLQV---QEKL--QREAKEQEERAMEQKHINESLK 427
               +E+  EKE + +  +E+M  ++ ++   +EK+  Q + +EQEE+  E++ I E  K
Sbjct: 412 MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 471

Query: 428 ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQS----QEAEKEEKRREFEAGVAANKMC 483
               E K      +   QE + + Q +  ++Q+     QE  +EE++R+ +  +   +  
Sbjct: 472 RQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 531

Query: 484 LDKVQEVLSTHQVLPQNIHPMRK 506
           + + +E+    + + +    +RK
Sbjct: 532 IREQEEIWRQKEKIHEQEEKIRK 554



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 50/227 (22%), Positives = 98/227 (43%), Gaps = 15/227 (6%)

Query: 23  VRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRAR 82
           +R +  K +  E  + R      +   I    K  E++ +   W Q    +  + + R +
Sbjct: 486 IREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEM---WRQEEKIREQEEIWRQK 542

Query: 83  IKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEK-- 140
            K   Q   I  +E +   +E    ++ E   E + K    EEK     EK +  +EK  
Sbjct: 543 EKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIR 602

Query: 141 NEKERQDFVAEKLDQQFRERCE-----ELRVELLSIHQKKVCEERKAQIAFNEELSRQKL 195
            ++E      EK+ +Q  + CE     + + E +   ++K+ E+ K      E++  Q+ 
Sbjct: 603 EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 662

Query: 196 VEEQMFSKLWE-EDRLAKEKREAQE----ARRQKELMENTRLGLNAQ 237
           + ++   K+WE E+++ +++ + QE     RRQ+E M    + L  Q
Sbjct: 663 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ 709


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score =  103 bits (257), Expect = 4e-22
 Identities = 100/435 (22%), Positives = 222/435 (51%), Gaps = 46/435 (10%)

Query: 59  RDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQL 118
           RD+ +  W+Q    +  +  +R + K         + E+  K+RE   ++E E  T  Q 
Sbjct: 393 RDQEERMWEQDERLREKEERMREQEK---------MWEQVEKMREEKKMQEQEKKTRDQE 443

Query: 119 KK----ETIEEKKDRMREKTKLLKEKNEK--ERQDFVAEKLDQQFRERCEELRVELLSIH 172
           +K    E I E++ +MRE+ + ++E+ EK  ++++ + E+ ++++++  + L  +   + 
Sbjct: 444 EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQ--QRLPEQKEKLW 501

Query: 173 QKKVCEERKAQIAFNEELSRQKLVEEQMFS---KLWEEDRLAK------EKREAQEARRQ 223
           +++  +E++ +I   EE  R    +E+M+    K+W ++++ +      E+ E    + Q
Sbjct: 502 EQEKMQEQEEKIWEQEEKIRD---QEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ 558

Query: 224 KELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQE 283
           K   +  R+    Q    K   Q  ++ +EE  R  E      K   E++M+++Q+ K +
Sbjct: 559 KMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK-----KMREEEEMMREQEEKMQ 613

Query: 284 TRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYH 343
            +   ++ +QE+ E + ++    Q+   K+ ++  +  ++E    +Q+R    +E+   H
Sbjct: 614 EQ---EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 670

Query: 344 KYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQE 403
           + +   +E+EK QE+E ++I E++K +K  ++ ++   ++E  R+        +K++ +E
Sbjct: 671 EKM---QEQEKMQEQE-EKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEE 726

Query: 404 KLQREAKE----QEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQ 459
           ++ RE +E    QEE+  EQ+      +E   E++E    +QRL  E +++L      Q+
Sbjct: 727 EMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRL-PEQKEKLWEHEKMQE 785

Query: 460 QSQEAEKEEKRREFE 474
           Q +  E+EEK R+ E
Sbjct: 786 QEKIWEQEEKMRDQE 800



 Score =  102 bits (253), Expect = 1e-21
 Identities = 97/432 (22%), Positives = 225/432 (52%), Gaps = 39/432 (9%)

Query: 92  INIEERRNKLRELLALEENEYFTEMQLKKETIEEK----KDRMREKTKLLKEKNEKE-RQ 146
           +N++E + KL       E   F   Q++  T++E+    ++ +RE+ K ++++ EK  RQ
Sbjct: 246 LNVKELKRKL-------ERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQ 298

Query: 147 DFVAEKLDQQFRERCEEL-RVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLW 205
           +    + + + RE+ E++ R E     Q+K   E++ ++   +EL  Q+   ++   K+W
Sbjct: 299 EERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMW 358

Query: 206 EEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQAT----QLLKEEEARLVES 261
           E++   +E+ E  +  RQ+E +      +  Q   ++ Q +      + L+E+E R+ E 
Sbjct: 359 EQEEKMREQEE--KMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQ 416

Query: 262 NNAQIKHENEQDMLKKQKAKQETRTILQKALQE-RIEHIQQEYRDEQDL---NMKLVQRA 317
                + E  ++  K Q+ +++TR   +K  +E RI   +++ R+E++      + +Q+ 
Sbjct: 417 EKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQ 476

Query: 318 LQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEE--DKAKKLAEK 375
            +++ E+ +K+ Q++    +++K++ +   Q +EE+  +++E  R  EE   + KK+  +
Sbjct: 477 EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ 536

Query: 376 DK-----ELRLEKEARRQLVDEVMCTRKLQVQEKLQREAK---EQEERAMEQKHINESLK 427
           +K     +   E+E + +  ++ M  ++ ++++K Q + K   +QEE+  E++ + E  K
Sbjct: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596

Query: 428 ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKV 487
           ++  EE+E    ++   QE  +++Q     +Q+ +  E+EEK +E E  +   +  + + 
Sbjct: 597 KMR-EEEEMMREQEEKMQEQEEKMQ-----EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQ 650

Query: 488 QEVLSTHQVLPQ 499
           +E +   Q LP+
Sbjct: 651 EEKMWEQQRLPE 662



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 99/410 (24%), Positives = 203/410 (49%), Gaps = 33/410 (8%)

Query: 95  EERRNKLRELLALEENEYFTEMQLKKETIEEK----KDRMREKTKLLKEKNEKERQDFVA 150
           +E++ + +E     + E   E + K    EEK    + R+RE+ K L+E+ ++ R+    
Sbjct: 284 QEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKEL 343

Query: 151 EKLDQQFRERCEEL--RVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
            + ++Q +E+ E++  + E +   ++K+  + +      +++  Q+        ++WE+D
Sbjct: 344 REQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQD 403

Query: 209 RLAKEKRE-AQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVES---NNA 264
              +EK E  +E  +  E +E  R     Q    K + Q  ++ +EE  R  E       
Sbjct: 404 ERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEE 463

Query: 265 QIKHENEQDMLKKQKA--KQETRTILQKALQERIEHI-QQEYRDEQDLNMKLVQRALQDL 321
           +   E E+ M K+++   +QE +   Q+ L E+ E + +QE   EQ+  +   +  ++D 
Sbjct: 464 ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 523

Query: 322 QEE-ADKKKQKREDMIREQ--KIYHKYLAQRREEEKA--QEKEFDRILEEDKAK------ 370
           +E    +KK  R++ +REQ  +++ +    R +E+K   QE+  ++  +E + K      
Sbjct: 524 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE 583

Query: 371 ------KLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINE 424
                 ++ E++K++R E+E  R+  +E M  ++ ++QE+ + +  EQEE+  EQ+    
Sbjct: 584 KMREEERMREREKKMREEEEMMRE-QEEKMQEQEEKMQEQ-EEKMWEQEEKMQEQEEKMW 641

Query: 425 SLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFE 474
             +E   E++E    +QRL  E +++L      Q+Q +  E+EEK  E E
Sbjct: 642 EQEEKMWEQEEKMWEQQRL-PEQKEKLWEHEKMQEQEKMQEQEEKIWEQE 690



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 86/395 (21%), Positives = 199/395 (50%), Gaps = 29/395 (7%)

Query: 95  EERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLD 154
           +E++ + +E    ++ E   E     E + EK++RMRE+ K+  E+ EK R++   ++ +
Sbjct: 381 QEKQMREQEQKMRDQEERMWEQD---ERLREKEERMREQEKMW-EQVEKMREEKKMQEQE 436

Query: 155 QQFRERCEELRVE-LLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKE 213
           ++ R++ E+++ E  +   +KK+ EE +      E++ +Q+    +   K W++ RL ++
Sbjct: 437 KKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 496

Query: 214 KREAQEARRQKELMENT-----RLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
           K +  E  + +E  E       ++    ++   + +    + ++E+E ++ E        
Sbjct: 497 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 556

Query: 269 E----NEQDMLKKQKAKQETRTILQKAL---QERIEHIQQEYRDEQDLNMKLVQRALQDL 321
           E    ++++ ++K+  +QE +T  Q+     +ER+   +++ R+E+++      R  ++ 
Sbjct: 557 EQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEM-----MREQEEK 611

Query: 322 QEEADKKKQKREDMI--REQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKEL 379
            +E ++K Q++E+ +  +E+K+  +      +EEK  E+E +++ E+ +  +  EK  E 
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE-EKMWEQQRLPEQKEKLWEH 670

Query: 380 RLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFAR 439
              +E  +    E     K+  QEK++++ +EQE++  +Q+ + E       E+K     
Sbjct: 671 EKMQEQEKMQEQE----EKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEE 726

Query: 440 RQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFE 474
                QE + Q Q +   +Q+ +  E+EEK  E E
Sbjct: 727 EMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQE 761



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 105/408 (25%), Positives = 202/408 (49%), Gaps = 49/408 (12%)

Query: 94  IEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKT--------------KLLKE 139
           + E+  +LRE   L E E   +MQ ++E + E++++MRE+               K ++E
Sbjct: 330 LREQEKELREQKELREQE--EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE 387

Query: 140 KNEKER-QDFVAEKLDQQFRERCEELRVELLSIHQ-KKVCEERKAQIAFNEELSRQKLVE 197
           + +K R Q+    + D++ RE+ E +R +     Q +K+ EE+K Q    E+  + +  E
Sbjct: 388 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQ----EQEKKTRDQE 443

Query: 198 EQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEAR 257
           E+M  +    +R  K + E +  R Q+E M+     +  Q    + +    Q L E++ +
Sbjct: 444 EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ----EEKEWQQQRLPEQKEK 499

Query: 258 LVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRA 317
           L E    Q + E   +  +K + ++E     +K  ++     Q++   EQ+  M+  ++ 
Sbjct: 500 LWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQK 559

Query: 318 LQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDK 377
           + D +E  +KK Q++E    +Q+       + REEE+ +E+E     EE+  ++  EK +
Sbjct: 560 MWDQEERMEKKTQEQEKKTWDQE------EKMREEERMREREKKMREEEEMMREQEEKMQ 613

Query: 378 ELRLEKEARRQLVDEVMCTRKLQVQEKLQR----EAK--EQEERAMEQKHINESLKELNC 431
           E    +E + Q  +E M  ++ ++QE+ ++    E K  EQEE+  EQ+ + E  ++L  
Sbjct: 614 E----QEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 669

Query: 432 EEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEK----EEKRREFEA 475
            EK    + Q   QE  +++  Q   ++++QE EK    +EK RE E+
Sbjct: 670 HEK---MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEES 714



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 94/397 (23%), Positives = 182/397 (45%), Gaps = 57/397 (14%)

Query: 96  ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
           E   K R+ L+LE         +  E +++K   ++EK  L  E  + E Q  V E    
Sbjct: 200 EELTKERDALSLE----LYRNTITNEELKKKNAELQEKLPLA-ESEKSEIQLNVKE---- 250

Query: 156 QFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKR 215
             + + E  +  L  +    + EE   Q    EEL  Q+    +   K+W ++   +E+ 
Sbjct: 251 -LKRKLERAKFLLPQVQTNTLQEEMWRQ---EEELREQEKKIRKQEEKMWRQEERLREQE 306

Query: 216 EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDML 275
                + +K   +  RL            R+  + L+E+E  L E    + + E  Q+  
Sbjct: 307 GKMREQEEKMWRQEKRL------------REQEKELREQEKELREQKELREQEEQMQEQE 354

Query: 276 KKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE---EADKKKQKR 332
           +K   ++E     +   QE     Q+E   EQ+  M+  ++ ++D +E   E D++ +++
Sbjct: 355 EKMWEQEE-----KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK 409

Query: 333 EDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAK---KLAEKDKELRLEKEARRQL 389
           E+ +REQ+   + + + REE+K QE+E     +E+K +   ++ E++K++R E+E  R+ 
Sbjct: 410 EERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQ 469

Query: 390 VDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEK------------ENF 437
            +      K+Q QE+      EQEE+  +Q+ + E  ++L  +EK            E  
Sbjct: 470 EE------KMQKQEE---NMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 520

Query: 438 ARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFE 474
             ++ +  + +K  + +   +Q+ Q  E+EEK R+ E
Sbjct: 521 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 557



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 102/456 (22%), Positives = 208/456 (45%), Gaps = 57/456 (12%)

Query: 38  ERIRRSHQKHNAILASIKSSERDRLKAE---WDQHNDCKILDSLVRARIKDAVQGFIINI 94
           ERIR   +K      +++  E    K E   W+Q         L   + K   Q  +   
Sbjct: 450 ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 509

Query: 95  EERRNKLRELLALEENEYFTEMQL-KKETIEEKKDRMREKTKLLKEKNEK-----ERQDF 148
           EE+  +  E +  +E  +  E ++ ++E + E++D+M E+ + ++++ +K     ER + 
Sbjct: 510 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569

Query: 149 VAEKLDQQFRERCEELRVE-LLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEE 207
             ++ +++  ++ E++R E  +   +KK+ EE +      E++  Q+   ++   K+WE+
Sbjct: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629

Query: 208 DRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK 267
           +   +E+ E    + +K   +  ++                     E+ RL E      +
Sbjct: 630 EEKMQEQEEKMWEQEEKMWEQEEKMW--------------------EQQRLPEQKEKLWE 669

Query: 268 HENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADK 327
           HE  Q+  K Q+  QE +   Q+ ++++ +  +++  D++ +         ++   E +K
Sbjct: 670 HEKMQEQEKMQE--QEEKIWEQEKMEKKTQEQEKKTWDQEKMRE-------EESMREREK 720

Query: 328 KKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARR 387
           K ++ E+M+REQ+        + +EEK QE+E +   +E+K  +  EK  E +   E + 
Sbjct: 721 KMREEEEMMREQEE-----KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE 775

Query: 388 QLVDEVMCTRKLQVQEKL---QREAKEQEE--RAMEQKHINESLKELNCEEKENFARRQR 442
           +L +      K+Q QEK+   + + ++QEE  R  E+K   +  K    EEK      + 
Sbjct: 776 KLWEH----EKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKM 831

Query: 443 LAQEYRKQLQMQIAYQQQSQEAEK----EEKRREFE 474
             QE +   Q +  + Q+ +  EK    EEK RE E
Sbjct: 832 WGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQE 867



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 83/351 (23%), Positives = 176/351 (50%), Gaps = 27/351 (7%)

Query: 96  ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
           E+  K+R+    E+  +  E +++K+T E++K    ++ K+ +E+  +ER+  + E+ ++
Sbjct: 548 EQEEKMRDQ---EQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREE-EE 603

Query: 156 QFRERCEELRV--ELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKE 213
             RE+ E+++   E +   ++K+ E+ +      E++  Q+    +   K+WE+ RL ++
Sbjct: 604 MMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQ 663

Query: 214 KR---EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVES-NNAQIKHE 269
           K    E ++ + Q+++ E        +    K Q Q  +   +E+ R  ES    + K  
Sbjct: 664 KEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMR 723

Query: 270 NEQDMLKKQKAKQETRTILQKALQERIEHI--QQEYRDEQDLNMKLVQRALQDLQEEADK 327
            E++M+++Q+ K + +   ++ +QE+ E +  Q+E   EQ+  M   QR       E  +
Sbjct: 724 EEEEMMREQEEKMQEQ---EEKMQEQEEEMWEQEEKMWEQEEKMWEQQRL-----PEQKE 775

Query: 328 KKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEK---DKELRLEKE 384
           K  + E M  ++KI+ +    R +EEK + +E     +E+K +   EK    +E    +E
Sbjct: 776 KLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQE 835

Query: 385 ARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKE 435
            +    +E M  ++ +++EK+Q     QEE+  EQ+      +E   E++E
Sbjct: 836 EKMWGQEEKMWGQEEKMEEKMQG----QEEKMREQEEKMRGQEEKMREQEE 882



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 76/366 (20%), Positives = 181/366 (49%), Gaps = 33/366 (9%)

Query: 59  RDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQL 118
           RD+ +  WDQ             R++   Q       ++  K+RE   + E E   +M+ 
Sbjct: 554 RDQEQKMWDQEE-----------RMEKKTQEQEKKTWDQEEKMREEERMRERE--KKMRE 600

Query: 119 KKETIEEKKDRMREKTKLLKEKNEKE-RQDFVAEKLDQQFRERCEELRVELLSIHQKKVC 177
           ++E + E++++M+E+ + ++E+ EK   Q+   ++ +++  E+ E++  +   + +++  
Sbjct: 601 EEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRL 660

Query: 178 EERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQ 237
            E+K ++  +E++  Q+ ++EQ   K+WE++++ K+ +E ++    +E M         +
Sbjct: 661 PEQKEKLWEHEKMQEQEKMQEQE-EKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRERE 719

Query: 238 ITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIE 297
               K  R+  ++++E+E ++ E      + E E    +++  +QE +   Q+ L E+ E
Sbjct: 720 ----KKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE 775

Query: 298 HIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMI-REQKIYHKYLAQRREEEKAQ 356
            + +  + ++           + + E+ +K + + E M  +E+K+  +    R +EEK  
Sbjct: 776 KLWEHEKMQEQ----------EKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMW 825

Query: 357 EKEFDRILEEDKAKKLAEK--DKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEE 414
            +E     +E+K     EK   +E ++E++ + Q         K++ QE+  RE +E++ 
Sbjct: 826 GQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMRE-QEEKM 884

Query: 415 RAMEQK 420
           R  E+K
Sbjct: 885 RGQEEK 890



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 64/288 (22%), Positives = 134/288 (46%), Gaps = 29/288 (10%)

Query: 242 KAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIE-HIQ 300
           KA R   +L KE +A  +E     I +E     LKK+ A+ + +  L ++ +  I+ +++
Sbjct: 194 KADRYIEELTKERDALSLELYRNTITNEE----LKKKNAELQEKLPLAESEKSEIQLNVK 249

Query: 301 QEYRDEQDLNMKLVQ-----------RALQDLQEEADKKKQKREDMIREQKIYHKYLAQR 349
           +  R  +     L Q           R  ++L+E+  K +++ E M R+++   +   + 
Sbjct: 250 ELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKM 309

Query: 350 REEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREA 409
           RE+E+   ++  R+ E++K  +L E++KELR +KE R Q         K+  QE+  RE 
Sbjct: 310 REQEEKMWRQEKRLREQEK--ELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQ 367

Query: 410 KE-----------QEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQ 458
           +E           QE++  EQ+      +E   E+ E    ++   +E  K  +     +
Sbjct: 368 EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMR 427

Query: 459 QQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNIHPMRK 506
           ++ +  E+E+K R+ E  +   +   ++ +++    + + +    M+K
Sbjct: 428 EEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQK 475


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 83/407 (20%), Positives = 207/407 (50%), Gaps = 39/407 (9%)

Query: 92  INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAE 151
           +++E  RN + +    E+N    ++Q K + +E +K  ++   K LK K E+ +      
Sbjct: 193 LSLELYRNTITDEELKEKN---AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP-- 247

Query: 152 KLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLA 211
              QQ +   + L  EL S+  K      +AQ+  NE  +R   + +Q   K+W ++   
Sbjct: 248 --QQQLQAEADHLGKELQSVSAKL-----QAQVEENELWNR---LNQQQEEKMWRQEEKI 297

Query: 212 KEKREAQEARRQKELMENTRLGLNAQITSIKAQ--RQATQLLKEEEARLVESNNAQIKHE 269
           +E+ E  + + +K   +  ++    ++   K +  R+  +++ E+E ++ E      + E
Sbjct: 298 QEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 357

Query: 270 NEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKK 329
             ++  +K++ +++ R   ++  QE     Q+E   EQ+  ++  +  +Q+ +E+  +++
Sbjct: 358 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQE 417

Query: 330 QKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQL 389
           +K  +  +E+++  +    RR+EEK +E+E          KK+ E+++++R ++E  ++ 
Sbjct: 418 EKMWE--QEEEMQEQEEKMRRQEEKIREQE----------KKIREQEEKIREQEEMMQEQ 465

Query: 390 VDEV------MCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRL 443
            +++      MC ++ ++QE+ ++  +++E+   ++K I E  +++  +E+    + +++
Sbjct: 466 EEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 525

Query: 444 AQEYRKQLQMQIAYQQQSQEAEK-EEKRREFEAGVAANKMCLDKVQE 489
            ++  K  + +   Q+Q ++  + EEK RE E  +   +   +K+QE
Sbjct: 526 WEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQE---EKMQE 569



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 83/386 (21%), Positives = 192/386 (49%), Gaps = 48/386 (12%)

Query: 122 TIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERK 181
           T ++K DR  E+  L KE++    + +     D++ +E+  +L+ +L      ++ E  K
Sbjct: 174 TQKKKADRYIEE--LTKERDALSLELYRNTITDEELKEKNAKLQEKL------QLVESEK 225

Query: 182 AQIAFN-----EELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNA 236
           ++I  N      +L R KL+  Q   +  E D L KE +    A+ Q ++ EN       
Sbjct: 226 SEIQLNVKELKRKLERAKLLLPQQQLQA-EADHLGKELQSVS-AKLQAQVEEN------- 276

Query: 237 QITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERI 296
           ++ +   Q+Q  ++ ++EE   ++    +I+ + E+   +++K +++   + +K  +E++
Sbjct: 277 ELWNRLNQQQEEKMWRQEEK--IQEREEKIQEQEEKIREQEEKMRRQEEMMWEK--EEKM 332

Query: 297 EHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQ 356
              Q+E   E++  +    R L++   E +K +++ E    E+KI        RE+EK Q
Sbjct: 333 RR-QEEMMWEKEEKI----RELEEKMHEQEKIREQEEKRQEEEKI--------REQEKRQ 379

Query: 357 EKEFDRILEEDKAKKLAEK---DKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQE 413
           E+E     +E+K ++  EK    +E+  E+E +    +E M  ++ ++QE+ ++  +++E
Sbjct: 380 EQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEE 439

Query: 414 ERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
           +   ++K I E  +++  +E+    + +++ ++  K  +      Q+++  E+EEK R  
Sbjct: 440 KIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCE------QEAKMQEQEEKMRRQ 493

Query: 474 EAGVAANKMCLDKVQEVLSTHQVLPQ 499
           E  +   +  + + +E +   + + Q
Sbjct: 494 EEKIREQEKKIREQEEKIREQEEMMQ 519



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 60/293 (20%), Positives = 130/293 (44%), Gaps = 37/293 (12%)

Query: 210 LAKEKREAQEARRQKELME-----NTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNA 264
           ++KE R+++ A  +++L +     N  +G  A  T  K     T              + 
Sbjct: 39  MSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDE 98

Query: 265 Q-IKHENEQDMLKKQKAKQET-------RTILQKALQERIEHIQQEYRDEQDLNMKL--- 313
           Q   H++++ + ++ +A+ +T       +T LQ AL      ++Q   + +DL  +L   
Sbjct: 99  QKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDS 158

Query: 314 ------VQRALQDLQEEADKKKQKREDMIREQ-----KIYHKYLAQRREEEKAQEKEFDR 362
                 +++AL  +  +  K  +  E++ +E+     ++Y   +     +EK  + +   
Sbjct: 159 WKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKL 218

Query: 363 ILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQ-EKLQREAKEQEERAMEQKH 421
            L E +  ++    KEL+ + E  + L+ +    ++LQ + + L +E +    +   Q  
Sbjct: 219 QLVESEKSEIQLNVKELKRKLERAKLLLPQ----QQLQAEADHLGKELQSVSAKLQAQVE 274

Query: 422 INESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFE 474
            NE    LN +++E   R++   QE  +++Q     +Q+ +  E+EEK R  E
Sbjct: 275 ENELWNRLNQQQEEKMWRQEEKIQEREEKIQ-----EQEEKIREQEEKMRRQE 322


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 96.3 bits (238), Expect = 6e-20
 Identities = 90/420 (21%), Positives = 208/420 (49%), Gaps = 35/420 (8%)

Query: 95  EERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLD 154
           +E++ + +E    ++ E   E     E + EK++RMRE+ K+ +++ + + ++ + E+ +
Sbjct: 343 QEKQMREQEQKMRDQEERMWEQD---ERLREKEERMREQEKMWEQEEKMQEEERIRER-E 398

Query: 155 QQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEK 214
           ++ RE  E +R +     +K   +E        +E  +Q+L E++   KLWE++++ +++
Sbjct: 399 KKMREEEETMREQ----EEKMQKQEENMWEQEEKEWQQQRLPEQK--EKLWEQEKMQEQE 452

Query: 215 REAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDM 274
            +  E + +K   +    G   ++   +  R+    + E+E ++ +        E     
Sbjct: 453 EKIWE-QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWE 511

Query: 275 LKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE---EADKKKQK 331
             ++  ++E R   QK + ++ E +++E + ++       Q      +E   E +KK ++
Sbjct: 512 QDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMRE 571

Query: 332 REDMIREQ--KIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQL 389
            E+M+REQ  K+  +    R +EEK  E+E    ++E + K   +++K    E+E + Q 
Sbjct: 572 EEEMMREQEEKMQEQEEKMREQEEKMWEQE--EKMQEQEEKMWEQEEKMWEQEEEDKMQE 629

Query: 390 VDEVMCTRKLQVQEKLQR------EAKEQEERAMEQKHINESLKELNCEEKENFARRQRL 443
            +E+M  ++ ++QE+ ++      + +EQEE+  EQ+   +  +E   E++E    ++  
Sbjct: 630 QEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEK 689

Query: 444 AQEYRKQLQMQ---IAYQQQSQEAEKE-----EKRREFEAGVAANKMCLDKVQEVLSTHQ 495
            +E  ++++ Q   +  Q++    ++E     E+ RE E  +   K   +K+QE L  H+
Sbjct: 690 MREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQK---EKMQERLPEHE 746



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 94/431 (21%), Positives = 212/431 (49%), Gaps = 62/431 (14%)

Query: 92  INIEERRNKLRELLALEENEYFTEMQLKKETIEEK----KDRMREKTKLLKEKNEKE-RQ 146
           +N++E + KL       E   F   Q++  T++E+    ++ +RE+ K ++++ EK  RQ
Sbjct: 208 LNVKELKRKL-------ERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQ 260

Query: 147 DFVAEKLDQQFRERCEELRVELLSIH-QKKVCEERKAQIAFNEELSRQKLVEEQMFSKLW 205
           +    + + + RE+ E++R +   +  Q+K   E++ ++   ++L  Q+   ++   K+W
Sbjct: 261 EERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMW 320

Query: 206 EEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQ 265
           E++   +E+ E    R+++ L E             K  R+  Q ++++E R+ E +   
Sbjct: 321 EQEEKMREQEEKMW-RQEERLWEQE-----------KQMREQEQKMRDQEERMWEQDERL 368

Query: 266 IKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEA 325
              E E+ M +++K  ++   + +   +ERI   +++ R+E++               E 
Sbjct: 369 --REKEERMREQEKMWEQEEKMQE---EERIREREKKMREEEET------------MREQ 411

Query: 326 DKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEA 385
           ++K QK+E+ + EQ+   ++  QR  E+K +  E +++ E+++  K+ E+++++R ++E 
Sbjct: 412 EEKMQKQEENMWEQE-EKEWQQQRLPEQKEKLWEQEKMQEQEE--KIWEQEEKIRDQEEM 468

Query: 386 RRQLVDEVMCTRKLQVQEKLQREAK---EQEERAMEQKHINESLKELNCEEKENFARRQR 442
             Q        +K+  QEK++ +     EQEE+  +Q+      +E   E+ E    ++ 
Sbjct: 469 WGQ-------EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEE 521

Query: 443 LAQEYRKQLQMQ--IAYQQQSQEAEK-----EEKRREFEAGVAANKMCLDKVQEVLSTHQ 495
             +E +K  Q +  +  ++++QE EK     EEK RE E      K   ++ + +    +
Sbjct: 522 RMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE 581

Query: 496 VLPQNIHPMRK 506
            + +    MR+
Sbjct: 582 KMQEQEEKMRE 592



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 103/399 (25%), Positives = 181/399 (45%), Gaps = 46/399 (11%)

Query: 96  ERRNKLRELLALE-ENEYFTEMQLKKETIE-EKKDRMREKTKLLKEKNEKERQDFVAEKL 153
           E   K R+ L+LE      T  +LKK+  E ++K R+ E  K   + N KE         
Sbjct: 162 EELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKE--------- 212

Query: 154 DQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLW-EEDRL-- 210
               + + E  +  L  +    + EE   Q    EEL  Q+    +   K+W +E+RL  
Sbjct: 213 ---LKRKLERAKFLLPQVQTNTLQEEMWRQ---EEELREQEKKIRKQEEKMWRQEERLRE 266

Query: 211 --AKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
              K + + ++ RRQ++ +      L  Q   ++ Q++    L+E+E ++ E      + 
Sbjct: 267 QEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKK----LREQEEQMQEQEEKMWEQ 322

Query: 269 ENEQDMLKKQKAKQETRTILQKAL---QERIEHIQQEYRDEQDLNMKLVQRALQDLQEEA 325
           E +    +++  +QE R   Q+     QE+    Q+E   EQD  +    R  ++   E 
Sbjct: 323 EEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL----REKEERMREQ 378

Query: 326 DKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEA 385
           +K  ++ E M  E++I  +    R EEE  +E       +E+K +K  E   E + EKE 
Sbjct: 379 EKMWEQEEKMQEEERIREREKKMREEEETMRE-------QEEKMQKQEENMWE-QEEKEW 430

Query: 386 RRQLVDEVMCTRKLQVQEKLQREAK---EQEERAMEQKHINESLKELNCEEKENFARRQR 442
           ++Q + E     KL  QEK+Q + +   EQEE+  +Q+ +    K++  +EK      Q 
Sbjct: 431 QQQRLPEQ--KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 488

Query: 443 LAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANK 481
             QE + + Q Q  + Q+ +  E++E+ RE E  +   K
Sbjct: 489 WEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQK 527



 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 86/393 (21%), Positives = 203/393 (51%), Gaps = 39/393 (9%)

Query: 94  IEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEK--ERQDFVAE 151
           + E+  ++RE   + E E   E   ++E I E++ +MRE+ + ++E+ EK  ++++ + E
Sbjct: 368 LREKEERMREQEKMWEQE---EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 424

Query: 152 KLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS---KLWEED 208
           + ++++++  + L  +   + +++  +E++ +I   EE  R    +E+M+    K+W ++
Sbjct: 425 QEEKEWQQ--QRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD---QEEMWGQEKKMWRQE 479

Query: 209 RLAK------EKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQL-LKEEEARLVES 261
           ++ +      E+ E    + QK   +  R+    +    K +R   Q  + ++E ++ E 
Sbjct: 480 KMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREE 539

Query: 262 NNAQIKHENEQDMLKKQKAKQETRTILQKALQER-IEHIQQEYRDEQDLNMKLVQRALQD 320
              Q + +   D  +K + ++  R   +K  +E  +   Q+E   EQ+  M+  +  + +
Sbjct: 540 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWE 599

Query: 321 LQE---EADKKKQKREDMIREQKIYHKYLAQR----REEEKAQEKEFDRILEEDKAKKLA 373
            +E   E ++K  ++E+ + EQ+   K   Q      +EEK QE+E +++ E++  +K+ 
Sbjct: 600 QEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQE-EKMWEQE--EKMR 656

Query: 374 EKDKELRLEKEARRQLVDEVMCTR--KLQVQEKLQREAKEQEERAMEQKHINESLKELNC 431
           E+++++R E+E + Q  +E M  +  K+Q QE+  RE +E++ R  E+K   +  K    
Sbjct: 657 EQEEKMR-EQEEKMQGQEEKMREQEEKMQGQEEKMRE-QEEKMRGQEEKMWGQEEKMWGQ 714

Query: 432 EEK----ENFARRQRLAQEYRKQLQMQIAYQQQ 460
           EEK    E    ++   ++ ++++Q ++   ++
Sbjct: 715 EEKMWGQEEMREKEERIRDQKEKMQERLPEHEE 747



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 84/344 (24%), Positives = 163/344 (47%), Gaps = 28/344 (8%)

Query: 172 HQKKVCEERKAQIAFNEELSRQK------LVEEQMFSKLWEEDRLAKEKREAQEARRQKE 225
           HQ+ +  E +AQ      L+ QK      L   Q  ++ +E+  L + K  A        
Sbjct: 79  HQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGESKDLAGRLHHSWH 138

Query: 226 LMENTRLGLNAQIT-SIKAQRQATQLLKEEEARLVES-----NNAQIKHENE--QDMLKK 277
                +  L+A  T   KA R   +L KE +A  +E       N ++K +N   Q+ L+ 
Sbjct: 139 FAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRL 198

Query: 278 QKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKL-VQRALQDLQEEADKKKQKREDMI 336
            ++++    +  K L+ ++E  +      Q   ++  + R  ++L+E+  K +++ E M 
Sbjct: 199 AESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMW 258

Query: 337 REQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCT 396
           R+++   +   + RE+E+   ++  R+ E++K  +L E++KELR +K+ R Q        
Sbjct: 259 RQEERLREQEGKMREQEEKMRRQEKRLREQEK--ELREQEKELREQKKLREQEEQMQEQE 316

Query: 397 RKLQVQEKLQREAKE----QEERAMEQ-KHINESLKELNCEEKENFARRQRLAQ------ 445
            K+  QE+  RE +E    QEER  EQ K + E  +++  +E+  + + +RL +      
Sbjct: 317 EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR 376

Query: 446 EYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQE 489
           E  K  + +   Q++ +  E+E+K RE E  +   +  + K +E
Sbjct: 377 EQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEE 420


>gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]
          Length = 495

 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 97/426 (22%), Positives = 203/426 (47%), Gaps = 36/426 (8%)

Query: 70  NDCKILDSLVRARIKDAVQGFII-NIEERRNKLRELLALEENEYFT-----EMQLKKETI 123
           N CK L       +   ++  ++ N  + R + ++ L L +NE F       +Q  +E  
Sbjct: 21  NYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENK 80

Query: 124 EEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQ 183
             K+ +++++ KL  E  + + +    EK+ QQ RE   ELR     +    + +ER AQ
Sbjct: 81  RLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQ 140

Query: 184 IAFNEELSRQKLVEEQMFSK--LWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSI 241
           IA  + +  +++  +   +K  + E  R+ KE+  A++ R + +      L    +    
Sbjct: 141 IAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEK 200

Query: 242 KAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQ 301
           K Q    QLLKE+   +++    +I  E++ +  +K +     R  +++  +E+    ++
Sbjct: 201 KKQEAYEQLLKEK--LMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKK 258

Query: 302 EYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFD 361
           +  + ++ N K+++ A    Q E D+  + +E+  +  ++ +  L Q+ EE   Q ++ +
Sbjct: 259 KREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNA-LTQKLEEMLRQREDLE 317

Query: 362 RILEE---------DKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQ 412
           ++ +E          K+K   E +K+LR +KE ++   +E M  ++L +Q      AKE+
Sbjct: 318 QVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDF-EEQMALKELVLQ-----AAKEE 371

Query: 413 EE---RAMEQKHINESLKELNCEEKENFARRQRLAQ-EYRKQLQMQIAYQQQSQEAEKEE 468
           EE   + M  K   +   EL        A++QR+ Q E+R+ ++  I  ++Q   A+K+ 
Sbjct: 372 EENFRKTMLAKFAEDDRIEL------MNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQR 425

Query: 469 KRREFE 474
           +  E++
Sbjct: 426 ELEEWQ 431



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 75/342 (21%), Positives = 155/342 (45%), Gaps = 57/342 (16%)

Query: 161 CEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREA--- 217
           C++L V+ L    K V  + + Q+  NE  +R   V+ + F +L + ++   +  EA   
Sbjct: 23  CKKLHVQAL----KNVNSQIRNQMVQNENDNR---VQRKQFLRLLQNEQFELDMEEAIQK 75

Query: 218 -QEARRQKELMENTRLGLNAQITSIKAQ-----------RQATQLLKEEEARLVES--NN 263
            +E +R KEL       L  ++  +K +           R+ +  L+E E +L  +  N 
Sbjct: 76  AEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNK 135

Query: 264 AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQ- 322
            +     E+D +K ++ K++    + K + E  + I +E    +D   K   +   DL+ 
Sbjct: 136 ERAAQIAEKDAIKYEQMKRDAE--IAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEK 193

Query: 323 --EEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELR 380
             EE +KKKQ+  + + ++K+    + ++             I EED+       +K+ +
Sbjct: 194 QLEEQEKKKQEAYEQLLKEKLMIDEIVRK-------------IYEEDQL------EKQQK 234

Query: 381 LEK-EARRQLVDEVMCTRKLQVQEKLQREAKEQEERA------MEQKHINESLKELNCEE 433
           LEK  A R+ ++E    ++  +  K +RE  E+E R       M+Q+   + + ++   E
Sbjct: 235 LEKMNAMRRYIEEFQ--KEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENE 292

Query: 434 KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
           ++    +  L Q+  + L+ +   +Q  QE  +EE+   +++
Sbjct: 293 EKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKS 334



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 62/278 (22%), Positives = 123/278 (44%), Gaps = 52/278 (18%)

Query: 96  ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRM---------REKTKLLK-EKNEKER 145
           E+ N +R  +   + E     + K+E +EE+  ++         RE+ ++ K ++NE++R
Sbjct: 236 EKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKR 295

Query: 146 ---QDFVAEKLDQQFRER--CEELRVELLSIHQ-------------KKVCEERKAQIAFN 187
              Q+ + +KL++  R+R   E++R EL    Q             KK+ ++++ +  F 
Sbjct: 296 LQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFE 355

Query: 188 EELSRQKLV------EEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSI 241
           E+++ ++LV      EE+ F K         ++ E   A++Q+      R  +   I   
Sbjct: 356 EQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEER 415

Query: 242 KAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQ 301
           + Q  A +  + EE +L +     I    E++ LK  K   E  T L   L + +     
Sbjct: 416 RQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLK---EHATNLLGYLPKGV----- 467

Query: 302 EYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQ 339
            ++ E D+++         L EE  K  Q+R ++  E+
Sbjct: 468 -FKKEDDIDL---------LGEEFRKVYQQRSEICEEK 495



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 45/190 (23%), Positives = 83/190 (43%), Gaps = 16/190 (8%)

Query: 319 QDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKE 378
           Q L +E   KK   + +          + Q   + + Q K+F R+L+ ++     E D E
Sbjct: 15  QKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQ----FELDME 70

Query: 379 LRLEKEARRQLVDEVMCTR--KLQVQ-EKLQREAKEQEERAMEQKHINESLKELNCEEKE 435
             ++K    + + E+   +  KL ++  KL+ E+ + E+   + +  +  L+EL  + K 
Sbjct: 71  EAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKA 130

Query: 436 NFARRQRLAQEYRKQLQMQIAYQQQSQEAE------KEEKRREFEAGVAANKMCLDKVQE 489
            +  ++R AQ   K     I Y+Q  ++AE      +E KR   E   A +K    K Q 
Sbjct: 131 AYMNKERAAQIAEKD---AIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQY 187

Query: 490 VLSTHQVLPQ 499
            L   + L +
Sbjct: 188 YLDLEKQLEE 197


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 77/314 (24%), Positives = 156/314 (49%), Gaps = 48/314 (15%)

Query: 199 QMFSKLWEEDRLA--KEKREAQEARRQK------ELMENTRLGLNAQITSIKAQRQATQL 250
           +M  K  E  RL   + K EA++ RRQK        +E  +L    ++  +   R+  + 
Sbjct: 527 RMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQ 586

Query: 251 LKEEEARLVESNNAQIKHENE---QDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQ 307
           +KEE+ + +E   AQI  + E   ++ L ++KAK+       KA  +++E ++   + E+
Sbjct: 587 MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKK-------KAAAKKMEEVEARRKQEE 639

Query: 308 DLN-MKLVQRALQDLQEEADKKKQKREDMIREQKIYH-KYLAQRREEEKAQEKEFDRILE 365
           +   ++ +Q+  ++ + +   +K+K E+  R +K    K LA++RE+E+ +++  ++   
Sbjct: 640 EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERR 699

Query: 366 EDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINES 425
           E + ++   +++E +L ++ RR+  + +   R+LQ +EK  R  KEQ +R +E+K   E 
Sbjct: 700 EQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKE- 758

Query: 426 LKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLD 485
                         +QRLA+   +QLQ            E+E+K +E      A  + +D
Sbjct: 759 -------------EQQRLAE---RQLQ-----------EEQEKKAKEAAGASKALNVTVD 791

Query: 486 KVQEVLSTHQVLPQ 499
                 +++Q+ PQ
Sbjct: 792 VQSPACTSYQMTPQ 805



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 82/319 (25%), Positives = 158/319 (49%), Gaps = 74/319 (23%)

Query: 95  EERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLD 154
           E+ R +L  L   EE E     QL+++ +EE K R  E+ KL +E+  ++          
Sbjct: 532 EKERQRLENLRRKEEAE-----QLRRQKVEEDKRRRLEEVKLKREERLRKVL-------- 578

Query: 155 QQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEK 214
            Q RER E+++            EE+K QI             EQ F+++ E+   AKE+
Sbjct: 579 -QARERVEQMK------------EEKKKQI-------------EQKFAQIDEKTEKAKEE 612

Query: 215 REAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDM 274
           R A+E  ++K   +        ++  ++A+R+     +EEEAR +     + +    Q++
Sbjct: 613 RLAEEKAKKKAAAK--------KMEEVEARRK-----QEEEARRLRWLQQEEEERRHQEL 659

Query: 275 LKKQKAKQETRTILQKALQER--IEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKR 332
           L+K+K +++ R  L+KA + +   E  +QE R+             Q+ +E+  +++++R
Sbjct: 660 LQKKKEEEQER--LRKAAEAKRLAEQREQERRE-------------QERREQERREQERR 704

Query: 333 EDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDE 392
           E   REQ+       +RRE+E+ Q +    + E +KA +L ++  +  LE++ +++   E
Sbjct: 705 EQERREQERQLAEQERRREQERLQAER--ELQEREKALRLQKEQLQRELEEKKKKE---E 759

Query: 393 VMCTRKLQVQEKLQREAKE 411
                + Q+QE+ +++AKE
Sbjct: 760 QQRLAERQLQEEQEKKAKE 778



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 74/318 (23%), Positives = 146/318 (45%), Gaps = 26/318 (8%)

Query: 191 SRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQL 250
           +R+K   +Q  S+L EE  L  E+ +   ++        +++    +      QR    +
Sbjct: 447 ARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLM 506

Query: 251 LKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLN 310
                 R V  +   IK      M  K+K +Q    + +K   E++              
Sbjct: 507 TPTSAPRSVMKSF--IKRNTPLRMDPKEKERQRLENLRRKEEAEQLRR------------ 552

Query: 311 MKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQ-EKEFDRILEE-DK 368
               Q+  +D +   ++ K KRE+ +R+     + + Q +EE+K Q E++F +I E+ +K
Sbjct: 553 ----QKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEK 608

Query: 369 AKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKE 428
           AK+  E+  E + +K+A  + ++EV   RK + + +  R  +++EE    Q+ + +  KE
Sbjct: 609 AKE--ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKK-KE 665

Query: 429 LNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEK-EEKRREFEAGVAANKMCLDKV 487
              E     A  +RLA++  ++ + Q   +Q+ +E E+ E++RRE E  +A  +    + 
Sbjct: 666 EEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQER--RRE 723

Query: 488 QEVLSTHQVLPQNIHPMR 505
           QE L   + L +    +R
Sbjct: 724 QERLQAERELQEREKALR 741



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 70/315 (22%), Positives = 135/315 (42%), Gaps = 54/315 (17%)

Query: 8   TVQREVKGPTP--------KVVIVRSKPPKGQGAE---HHLERIRRSHQKHNAILASIKS 56
           TVQR     TP        K  I R+ P +    E     LE +RR  +        ++ 
Sbjct: 498 TVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEE 557

Query: 57  SERDRLKAEWDQHNDC--KILDSLVRARI-----KDAVQGFIINIEERRNKLRELLALEE 109
            +R RL+    +  +   K+L +  R        K  ++     I+E+  K +E    EE
Sbjct: 558 DKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEE 617

Query: 110 NEYFTEMQLKKETIEEKKDRMREKTKL--LKEKNEKERQDFVAEKLDQQFRERCEELRVE 167
                    K E +E ++ +  E  +L  L+++ E+ R   + +K  ++ +ER  +    
Sbjct: 618 KAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK---- 673

Query: 168 LLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELM 227
             +   K++ E+R+ +    E   +++  +E+      E++R  +E++ A++ RR+    
Sbjct: 674 --AAEAKRLAEQREQERREQERREQERREQERR-----EQERREQERQLAEQERRR---- 722

Query: 228 ENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTI 287
           E  RL             QA + L+E E  L      +++ E  Q  L+++K K+E + +
Sbjct: 723 EQERL-------------QAERELQEREKAL------RLQKEQLQRELEEKKKKEEQQRL 763

Query: 288 LQKALQERIEHIQQE 302
            ++ LQE  E   +E
Sbjct: 764 AERQLQEEQEKKAKE 778


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 133/572 (23%), Positives = 253/572 (44%), Gaps = 112/572 (19%)

Query: 10   QREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQH 69
            + E++    +++ V+ K  K +G    LE + R HQ+    L   K+   ++L+AE +  
Sbjct: 851  EEELQAKDEELLKVKEKQTKVEG---ELEEMERKHQQ----LLEEKNILAEQLQAETELF 903

Query: 70   NDCKILDSLVRARIKDAVQGFIINIEER-----------RNKLRELLA--------LEEN 110
             + + + + + A+ K  ++  + ++E R           +N+ +++ A        L+E 
Sbjct: 904  AEAEEMRARLAAK-KQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE 962

Query: 111  EYFTE-MQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELL 169
            E   + +QL+K T E K  +M E+  LL+++N K    F+ EK  +   +R  E   +L 
Sbjct: 963  EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSK----FIKEK--KLMEDRIAECSSQLA 1016

Query: 170  SIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMEN 229
                    EE KA     + L++ +  +E M S L  E+RL KE++  QE  + K  ++ 
Sbjct: 1017 E-------EEEKA-----KNLAKIRNKQEVMISDL--EERLKKEEKTRQELEKAKRKLDG 1062

Query: 230  TRLGLNAQITSIKAQ--RQATQLLKEEE----------------------ARLVESNNAQ 265
                L  QI  ++AQ      QL K+EE                       R +++  A+
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE 1122

Query: 266  IKHENEQDMLKKQKAKQETRTILQ--KALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE 323
            ++ + E +   + KA+++ R + +  +AL+  +E        +Q+L  K  Q  + +L++
Sbjct: 1123 LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQE-VAELKK 1181

Query: 324  EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEK 383
              +++ +  E  I++ +  H    +   E+  Q K F   LE++K + L   +KEL  E 
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK-QGLETDNKELACEV 1240

Query: 384  EARRQLVDEVMCTRK---LQVQE---------KLQREAKEQEERAMEQKHINESLKELNC 431
            +  +Q+  E    RK    QVQE         +L+ E  E+  +   +     +L E   
Sbjct: 1241 KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAE 1300

Query: 432  EEKENFAR------------RQRLAQEYRKQLQMQIAYQQ--------QSQEAEKEEKRR 471
            ++   FA+            ++ L +E R++L +    +Q        Q Q+ E+EE R+
Sbjct: 1301 KKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARK 1360

Query: 472  EFEAGVAANKMCL----DKVQEVLSTHQVLPQ 499
              E  V A +  L     KV + L T + L +
Sbjct: 1361 NLEKQVLALQSQLADTKKKVDDDLGTIESLEE 1392



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 94/401 (23%), Positives = 195/401 (48%), Gaps = 51/401 (12%)

Query: 115  EMQLKKET-IEEKKDRMREKTKLLKEKNEKERQ------DFVAEKLDQ--QFRERCEELR 165
            E++ K+E  + E K  + E+TK  + + +  RQ      + ++E+L+Q  +F+   E+ +
Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226

Query: 166  VELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQ---MFSKLWEEDRLAKEKREAQEARR 222
              L + +++  CE +  Q    E   ++K ++ Q   + +K+ E DRL  E  E + ++ 
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAE-KASKL 1285

Query: 223  QKEL---------MENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH--ENE 271
            Q EL          E   +       S+++Q Q TQ L +EE R   + +++I+   E +
Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK 1345

Query: 272  QDMLKKQKAKQETRTILQK---ALQERIEHIQQEYRDE-------QDLNMKLVQRA---L 318
              + ++Q+ ++E R  L+K   ALQ ++   +++  D+       ++   KL++ A    
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405

Query: 319  QDLQEEA------DKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKL 372
            Q L+E+A      +K K + +  + +  +   +  Q     + ++K+FD++L E+K+   
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465

Query: 373  AEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCE 432
               ++  R E EAR +    +   R L  +E L  EAKE+ ER  + K +   +++L   
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARAL--EEAL--EAKEEFER--QNKQLRADMEDL-MS 1518

Query: 433  EKENFARRQRLAQEYRKQLQMQI-AYQQQSQEAEKEEKRRE 472
             K++  +     ++ ++ L+ Q+   + Q +E E E +  E
Sbjct: 1519 SKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATE 1559



 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 111/510 (21%), Positives = 223/510 (43%), Gaps = 96/510 (18%)

Query: 64   AEWDQHNDCKILDSLVRARIKDAVQGFIIN--IEERRNKLRELLALEEN----------- 110
            A  ++  D KI D ++    +   +G++      +++ +L  L  L+ N           
Sbjct: 776  AHLEEERDLKITDIIIF--FQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQ 833

Query: 111  --EYFTEMQLKKETIEEKKDRMREKTKLLKEKNEK------------------ERQDFVA 150
                FT+++   +   ++++   +  +LLK K ++                  E ++ +A
Sbjct: 834  WWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILA 893

Query: 151  EKL--DQQFRERCEELRVELLS-----------IHQKKVCEERKAQIAFNEELSRQKLV- 196
            E+L  + +     EE+R  L +           +  +   EE + QI  NE+   Q  + 
Sbjct: 894  EQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQ 953

Query: 197  --EEQMFSKLWEEDRLAKEK--REAQEARRQKELM----ENTRLGLNAQITSIKAQRQAT 248
              EEQ+  +     +L  EK   EA+  + ++E++    +N++     ++   +    ++
Sbjct: 954  DLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSS 1013

Query: 249  QLLKEEEARLVESNNAQIKHENE---QDMLKKQKAKQETRTILQKALQERIEHIQQEYRD 305
            QL +EEE      N A+I+++ E    D+ ++ K +++TR  L+KA ++    +  E  D
Sbjct: 1014 QLAEEEEK---AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK----LDGETTD 1066

Query: 306  EQDLNMKLVQRALQDLQEEADKKKQKREDMIR--EQKIYHKYLAQRREEE-KAQEKEFDR 362
             QD   +L Q  + +L+ +  KK+++ +  +   + +  HK  A +   E +AQ  E   
Sbjct: 1067 LQDQIAEL-QAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQE 1125

Query: 363  ILEEDKA-KKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKH 421
              E +KA +  AEK K         R L +E+    K ++++ L   A +QE R   ++ 
Sbjct: 1126 DFESEKASRNKAEKQK---------RDLSEELEAL-KTELEDTLDTTAAQQELRTKREQE 1175

Query: 422  INESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANK 481
            + E  K L  E K + A+ Q + Q +   L+         + +E+ E+ + F+A +  NK
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALE---------ELSEQLEQAKRFKANLEKNK 1226

Query: 482  MCLDK-----VQEVLSTHQVLPQNIHPMRK 506
              L+        EV    QV  ++ H  +K
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKK 1256



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 109/481 (22%), Positives = 203/481 (42%), Gaps = 81/481 (16%)

Query: 40   IRRSHQKHNAILASIKS------SERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIIN 93
            + +  +K + +LA  KS       ERDR +AE  +  + K L SL RA            
Sbjct: 1446 LEKKQKKFDQLLAEEKSISARYAEERDRAEAE-AREKETKAL-SLARA------------ 1491

Query: 94   IEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKL 153
            +EE         ALE  E F      K+   + +D M  K  + K  +E E+     E+ 
Sbjct: 1492 LEE---------ALEAKEEFERQN--KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQ 1540

Query: 154  DQQFRERCEELRVELLSIHQKKVCEERKAQIA---FNEELSRQKLVEEQMFSKLWEEDRL 210
             ++ R + EEL  EL +    K+  E   Q     F  +L  +    E+    L ++ R 
Sbjct: 1541 VEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVR- 1599

Query: 211  AKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK-HE 269
             + + E ++ R+Q+ L   ++  +   +  ++AQ +A    ++E  + +    AQ+K ++
Sbjct: 1600 -ELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQ 1658

Query: 270  NE-------------QDMLKKQKAKQETRTILQK----ALQERIEHIQQEYRDE---QDL 309
             E             Q    ++K K     ILQ     A  ER     ++ RDE   +  
Sbjct: 1659 RELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIT 1718

Query: 310  NMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQR----------------REEE 353
            N    + AL D +   + +  + E+ + E++   + L  R                 E  
Sbjct: 1719 NSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERS 1778

Query: 354  KAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQE 413
             AQ+ +  R   E + K+L  K +EL    +++ +     +  +  Q++E+L++EAKE+ 
Sbjct: 1779 AAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERA 1838

Query: 414  ERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIA----YQQQSQEAEKEEK 469
                  +   + LKE+  + ++     +R A +Y++Q++   A     ++Q +EAE+E  
Sbjct: 1839 AANKLVRRTEKKLKEIFMQVED----ERRHADQYKEQMEKANARMKQLKRQLEEAEEEAT 1894

Query: 470  R 470
            R
Sbjct: 1895 R 1895



 Score = 65.9 bits (159), Expect = 9e-11
 Identities = 90/430 (20%), Positives = 186/430 (43%), Gaps = 71/430 (16%)

Query: 93   NIEERRNKLRELLALEEN---EYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFV 149
            N+E+++ K  +LLA E++    Y  E    +    EK+ +     + L+E  E +     
Sbjct: 1445 NLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAK----- 1499

Query: 150  AEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDR 209
                 ++F  + ++LR ++  +   K            +++   K V E   SK   E +
Sbjct: 1500 -----EEFERQNKQLRADMEDLMSSK------------DDVG--KNVHELEKSKRALEQQ 1540

Query: 210  LAKEKREAQEARRQKELMENTRLGLNAQITSIKAQ----RQATQLLKEEEARLVESNNAQ 265
            + + + + +E   + +  E+ +L L   + ++KAQ     Q      EE+ RL+     +
Sbjct: 1541 VEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRE 1600

Query: 266  IKHENEQDMLKKQK----AKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDL 321
            ++ E E +  +KQ+    A ++   I  K L+ +IE    + RDE    ++ +Q  ++D 
Sbjct: 1601 LEAELEDE--RKQRALAVASKKKMEIDLKDLEAQIE-AANKARDEVIKQLRKLQAQMKDY 1657

Query: 322  QEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDK---- 377
            Q E ++ +  R+++  + K   K L     E    ++E   +   ++A++ AE+++    
Sbjct: 1658 QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEE---LASSERARRHAEQERDELA 1714

Query: 378  -ELRLEKEARRQLVDEV--MCTRKLQVQEKLQREAKEQE--------------------- 413
             E+      +  L+DE   +  R  Q++E+L+ E    E                     
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774

Query: 414  -ERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRRE 472
             ER+  QK  N + ++L  + KE  A+ Q L    + + +  I+  +      +E+  +E
Sbjct: 1775 AERSAAQKSDN-ARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQE 1833

Query: 473  FEAGVAANKM 482
             +   AANK+
Sbjct: 1834 AKERAAANKL 1843



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 85/404 (21%), Positives = 179/404 (44%), Gaps = 55/404 (13%)

Query: 159  ERCEELRVELLSIHQKKVCEERKAQIAF---NEELSRQKLVEEQMFSKL----WEEDRL- 210
            E   +L++  + I  + VC    A+ AF    ++LS  K+++    + L    W+  R+ 
Sbjct: 779  EEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVF 838

Query: 211  AKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHEN 270
             K K   Q  R+++EL       L  +    K + +  ++ ++ +  L E N    + + 
Sbjct: 839  TKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA 898

Query: 271  EQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNM------KLVQRALQDLQEE 324
            E ++  + +  +      ++ L+E +  ++    +E++ N       K +Q  +QDL+E+
Sbjct: 899  ETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958

Query: 325  ADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDK--AKKLAEKDKELRLE 382
             D+++  R+ +  E+      + +  EE    E +  + ++E K    ++AE   +L  E
Sbjct: 959  LDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018

Query: 383  KEARRQLV-----DEVMCT---RKLQVQEKLQREAKE------------QEERAMEQKHI 422
            +E  + L       EVM +    +L+ +EK ++E ++            Q++ A  Q  I
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQI 1078

Query: 423  NESLKELNCEEKE---------NFARRQRLAQEYRKQLQMQIAYQQQSQEAEK------E 467
            +E   +L  +E+E         +    +  A +  ++LQ QIA  Q+  E+EK      E
Sbjct: 1079 DELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAE 1138

Query: 468  EKRREFEAGVAANKMCLDKVQEVLSTHQVL----PQNIHPMRKA 507
            +++R+    + A K  L+   +  +  Q L     Q +  ++KA
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA 1182



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 84/409 (20%), Positives = 175/409 (42%), Gaps = 64/409 (15%)

Query: 22   IVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRA 81
            ++ SK   G+   H LE+ +R+ ++    + +      D L+A  D     ++    ++A
Sbjct: 1516 LMSSKDDVGKNV-HELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574

Query: 82   RIKDAVQGFIINIEERRNKL----RELLALEENEY----------------FTEMQLKKE 121
            + +  +Q      EE++  L    REL A  E+E                   +++ + E
Sbjct: 1575 QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIE 1634

Query: 122  TIEEKKDRMREKTKLLK----------EKNEKERQDFVAEKLDQQFRERCEELRVELLSI 171
               + +D + ++ + L+          E+    R +  A+  + +  ++ + L  E+L +
Sbjct: 1635 AANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESE--KKLKSLEAEILQL 1692

Query: 172  HQKKVCEERKAQIAFNEELSRQKLVEEQMFS----------KLWEEDRLAKEKREAQEAR 221
             ++    ER  + A   E  R +L +E   S          K   E R+A+ + E +E +
Sbjct: 1693 QEELASSERARRHA---EQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749

Query: 222  RQKELMEN----TRLGLNAQITSIKAQRQATQLLKEEEARL-VESNNAQIKHE-NEQDML 275
               EL+ +    T L ++     + A+R A Q  K + AR  +E  N ++K +  E +  
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLNAELAAERSAAQ--KSDNARQQLERQNKELKAKLQELEGA 1807

Query: 276  KKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDM 335
             K K K  T + L+  + +  E ++QE ++    N KLV+R         +KK ++    
Sbjct: 1808 VKSKFKA-TISALEAKIGQLEEQLEQEAKERAAAN-KLVRRT--------EKKLKEIFMQ 1857

Query: 336  IREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKE 384
            + +++ +     ++ E+  A+ K+  R LEE + +         +L++E
Sbjct: 1858 VEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRE 1906


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 120/517 (23%), Positives = 237/517 (45%), Gaps = 51/517 (9%)

Query: 2    YSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDR 61
            ++++   ++R ++     V  +R +  +    +   ER R   ++       +K++E  R
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW-QLKANEALR 1643

Query: 62   LKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLA----LEENEYFTEMQ 117
            L+ + ++    K L      + K+  +        RR K  E       L E E   + Q
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQ 1699

Query: 118  LKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRERC------EELRVELLS 170
            L + T +++    +E  +L  E  + E+Q   + E+L +  RE        +EL  EL  
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1759

Query: 171  IH-QKKVCEERKAQIA----FNEELSRQKL-VEEQMFSKLWEEDRLAKEKREAQEARRQK 224
            +  + +V    KA+         E S+Q+L  E   F +L EE   A+ +  A+EA+RQ+
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE--AARLRALAEEAKRQR 1817

Query: 225  ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQET 284
            +L E           + + + +A ++L E+ A + E+   ++K E E  + +K+   +  
Sbjct: 1818 QLAEED---------AARQRAEAERVLAEKLAAIGEAT--RLKTEAEIALKEKEAENERL 1866

Query: 285  RTILQKALQERIEHIQQEYRDEQDLNMKLVQ-RALQDLQEEADKKKQKREDMIREQK-IY 342
            R + +    +R    +Q  + + D+  +L Q R   D   E +++K   ED +R+++ + 
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVE 1924

Query: 343  HKYLAQRREEEKAQEKEFDRILEEDKAKKLAE----KDKELRLEKEARRQLVDEVMCTRK 398
             + LA +   EKA   + +  LE  + +  AE      ++  LE   +RQL  E    R+
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE-RRR 1983

Query: 399  LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM-QIAY 457
             + +E++Q+    +EE A ++K   E ++ L  + +E    R+R  QE  +QLQ+ Q A 
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043

Query: 458  QQQSQEAEK------EEKRREFEAGVAANKMCLDKVQ 488
            Q++ Q  EK      ++K +E +  +   +  LD+++
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 121/487 (24%), Positives = 226/487 (46%), Gaps = 49/487 (10%)

Query: 34   EHHLERIRRSHQKHNAILASIKSSERDRLKAEWD----QHNDCKILDSLVRARIKDAVQG 89
            E  L + R+  ++  A+ AS + +   + + E +    + N    L S  +A ++ A Q 
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973

Query: 90   FIINIEERRNK-----LRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE 144
             +   EERR +     +++ LA EE E   + +   E +E  K ++ E+ + L+E+ E+E
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKV-EEARRLRERAEQE 2031

Query: 145  --RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS 202
              RQ  +A++  Q+ R + EE +    ++ QK+  +E +  +   + +  Q   E +   
Sbjct: 2032 SARQLQLAQEAAQK-RLQAEE-KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAAR 2087

Query: 203  KLWEEDRLAK--EKREAQEARRQKELMENTRLGLNAQITS-IKAQRQATQLLKEEE---A 256
            +  EE   A+   +REA ++RRQ E  E  +     Q  +  +AQ  A +L KE E   A
Sbjct: 2088 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147

Query: 257  RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
            R  ++  A ++ +   D   ++  K   +T+ QKA  E+     +   +E D    L+  
Sbjct: 2148 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207

Query: 317  ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
             LQ L+ EA +  ++R  +  E       L   R + +   K   RI  E++A  L +KD
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEE-------LFSVRVQMEELSKLKARIEAENRALILRDKD 2260

Query: 377  KELRL---EKEARRQLVDEVM-CTRKLQVQEKLQREAKEQ--EERAMEQKHINESLK--- 427
               R    E E  +Q+ +E    +   Q   +L++ A+E   ++RA+ +K + E ++   
Sbjct: 2261 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320

Query: 428  ---------ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQS-QEAEKEEKRREFEAGV 477
                     EL  ++KE    + R  QE ++Q+  Q+A + Q  Q   + E++R+ E   
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380

Query: 478  AANKMCL 484
             A ++ L
Sbjct: 2381 EAERLKL 2387



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 110/422 (26%), Positives = 192/422 (45%), Gaps = 53/422 (12%)

Query: 96   ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
            E   +L E    EE E   E+    E   EK+ ++ E     K + E+E     A++L Q
Sbjct: 1345 EEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQAKAQAERE-----AKELQQ 1395

Query: 156  QFRE---RCEELRVELLSIHQKKVCEERKAQIAFNEEL-----SRQKLVEEQMFSKLWEE 207
            + +E   R EE  V+  +  QK+  +E   Q+  + E      +RQ    E+   ++ EE
Sbjct: 1396 RMQEEVVRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453

Query: 208  DRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK 267
             R+ + + EA E  RQ+   E     L A+    +AQ++  Q   E   R V+ + +Q K
Sbjct: 1454 IRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ-DESQRK 1510

Query: 268  HENEQDMLKKQKAKQETRTILQKALQE------RIEHIQQEYRDEQDLNMKLVQRALQDL 321
             + E ++  + KA+ E     Q+ALQ       + E  ++  R  +    + VQ AL+  
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570

Query: 322  QEEADKKKQ--------KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
            Q  A+ + Q        K   + R  +  H  +AQ REE    E+   +  E ++A++ A
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRAQQQAEAERAREEA 1627

Query: 374  EKDKE---LRLEKEARRQLVDEVMCTRKLQVQ-------EKLQREAKEQ---EERAMEQK 420
            E++ E   L+  +  R +L  E +  +K   Q       E+ +REA+ +   EE+A+ Q+
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1687

Query: 421  HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAY-QQQSQEAEKEEKRREFEAGVAA 479
             + E   E   +  E  A+++  A++   +L+ +    +QQ Q  E+E  R + EA  A 
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1747

Query: 480  NK 481
             K
Sbjct: 1748 QK 1749



 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 115/542 (21%), Positives = 227/542 (41%), Gaps = 98/542 (18%)

Query: 33   AEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFII 92
            A+   ER+RR  Q  +      +     R+KAE +   +        + R   A++   +
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--------KQRALQALEELRL 1543

Query: 93   NIEERRNKLRELLALEENEYFTEMQLKKET--------IEEKKDRMREKTKLLKEKNEKE 144
              EE   +LR+     E E   ++Q+  ET        ++ K+    EKT  L+   ++E
Sbjct: 1544 QAEEAERRLRQA----EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599

Query: 145  -------RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVE 197
                   R++       Q   ER  E     L   Q K  E  + ++   E   ++ L +
Sbjct: 1600 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1659

Query: 198  EQMFSKLWEEDRLAKEKREA------------QEARRQKELMENT---RLGLNAQITSIK 242
             +   +  E +R A+ + +A            QE  +Q++L E T   RL    ++  ++
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719

Query: 243  AQ----RQATQLLKEEEARL-------------VESNNAQIKHENEQDMLKKQKAKQETR 285
            A+     Q  QLL+EE ARL             +E+  A+++ E E  +  K +A++E+R
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779

Query: 286  TILQKALQE----------------RIEHIQQEYRDEQDLNMKLVQRALQDLQE------ 323
            +  +K+ Q                 R+  + +E + ++ L  +   R   + +       
Sbjct: 1780 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839

Query: 324  ----EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA---KKLAEKD 376
                EA + K + E  ++E++  ++ L +  E+E  Q +  +    + KA   ++LA+  
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899

Query: 377  KELRLEKEARRQLVDEVMCTRKLQVQEKL-------QREAKEQEERAMEQKHINESLKEL 429
            K    E E ++ LV++ +  R+ QV+E++       ++ A  + E  +E   I  + ++ 
Sbjct: 1900 KASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1958

Query: 430  --NCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKV 487
              + E+ E  A RQR      ++ + +   + Q   A +EE  R+ +A +   +    KV
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018

Query: 488  QE 489
            +E
Sbjct: 2019 EE 2020



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 88/386 (22%), Positives = 183/386 (47%), Gaps = 21/386 (5%)

Query: 92   INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKN-EKERQDFVA 150
            I ++E+  +   L  L E+E F   +L+++  + K D      +L K  + E ERQ  + 
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1913

Query: 151  EKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSR-QKLVEEQMFSKLWEEDR 209
            E   +Q R+  EE+ + L +  +K    + + ++    EL R +   E+ + SK   E  
Sbjct: 1914 EDTLRQRRQVEEEI-LALKASFEKAAAGKAELEL----ELGRIRSNAEDTLRSKEQAELE 1968

Query: 210  LAKEKR-EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
             A++++  A+E RR++E  E  +  L A+  + + ++ A + ++  +A++ E+   +++ 
Sbjct: 1969 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR--RLRE 2026

Query: 269  ENEQDMLKKQKAKQETRTILQKALQ-ERIEHIQQEYRDEQDLNMKLVQR--ALQDLQEEA 325
              EQ+  ++ +  QE     QK LQ E   H     + EQ+L   L Q    L  L+ EA
Sbjct: 2027 RAEQESARQLQLAQEAA---QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083

Query: 326  DKKKQKREDMIREQKIYHKYLAQRR----EEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
            +  ++  E+    +    +  AQ R    E E+ ++   ++     +A+  AEK ++   
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2143

Query: 382  EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
            ++ ARR   ++    +K     ++++  K  E+   ++  + + L  L  + +E   ++ 
Sbjct: 2144 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2203

Query: 442  RLAQE-YRKQLQMQIAYQQQSQEAEK 466
             L +E  R + +   A +Q+SQ  E+
Sbjct: 2204 LLDEELQRLKAEATEAARQRSQVEEE 2229



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 65/280 (23%), Positives = 143/280 (51%), Gaps = 29/280 (10%)

Query: 194  KLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKE 253
            K + E +  ++ EE+RLA+++R A+E  R  E+             +++ QRQ  +   +
Sbjct: 1335 KFISETL-RRMEEEERLAEQQR-AEERERLAEVE-----------AALEKQRQLAEAHAQ 1381

Query: 254  EEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKL 313
             +A+  E    +++   +++++++++A  + +   ++++QE ++ ++Q    E ++  K 
Sbjct: 1382 AKAQ-AEREAKELQQRMQEEVVRREEAAVDAQQ-QKRSIQEELQQLRQS--SEAEIQAKA 1437

Query: 314  VQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
             Q       E A++ + + E+ IR  ++  +   ++R   + + +      EE +A+K  
Sbjct: 1438 RQA------EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491

Query: 374  EKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEE 433
             +++  RL    RRQ+ DE    RK Q + +L    K + E A E++   ++L+EL  + 
Sbjct: 1492 AQEEAERL----RRQVQDESQ--RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1545

Query: 434  KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
            +E   R ++   E  +Q+Q+ +   Q+S EAE + KR  F
Sbjct: 1546 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 112/526 (21%), Positives = 218/526 (41%), Gaps = 92/526 (17%)

Query: 41   RRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNK 100
            +RS  +       ++  E  +LKA  +  N   IL      R KD  Q F+    E+  +
Sbjct: 2222 QRSQVEEELFSVRVQMEELSKLKARIEAENRALIL------RDKDNTQRFLQEEAEKMKQ 2275

Query: 101  LRE--------------LLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQ 146
            + E              L  L E +   +  L ++ ++EK   ++E T+L  E    ++Q
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335

Query: 147  DFVAEKLDQQFRERCEELRVELLSI---HQKKVCEERKAQIAFNEELSRQKL-VEEQMFS 202
              +A++  ++ +E  E++  +L       Q+ +  ER+ Q+  + E  R KL V E   +
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2395

Query: 203  KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQIT---SIKAQRQAT----------- 248
            +   E+   + +++A+E     E +  T L    ++T   +++ QRQ +           
Sbjct: 2396 QARAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2452

Query: 249  -QLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ------- 300
             +L +E+E    E+   Q+K E E   +++++  QET+ + Q  L E+   +Q       
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2511

Query: 301  ----------------QEYRDEQDLNMKLVQRALQDL---QEEADKKKQKREDMIR-EQK 340
                            Q+ R+EQ    + +++  Q L    EEA +++ + E+ +R +Q+
Sbjct: 2512 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2571

Query: 341  IYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKL- 399
               +   QRR++E+   +E  R+ E+    +L E+     L   +      +V  T+ L 
Sbjct: 2572 ELQQLEQQRRQQEELLAEENQRLREQ---LQLLEEQHRAAL-AHSEEVTASQVAATKTLP 2627

Query: 400  QVQEKLQREAKEQEER----AMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQI 455
              ++ L   A E E       + +K   + L+E      E     QRLAQ          
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQ---------- 2674

Query: 456  AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNI 501
             +    + A +E+ R   +   +   + L    E LS +  L + +
Sbjct: 2675 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL 2720



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 80/337 (23%), Positives = 143/337 (42%), Gaps = 63/337 (18%)

Query: 149  VAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
            V E+L Q+  ER  ++ VE       ++ E  +A +A       Q  V ++   +L  + 
Sbjct: 1159 VGERLQQRHGER--DVEVERWRERVAQLLERWQAVLA-------QTDVRQRELEQLGRQL 1209

Query: 209  RLAKEKREA-----QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNN 263
            R  +E  +      Q+ARR++E ++   L   A   +++ Q +  Q L EE         
Sbjct: 1210 RYYRESADPLGAWLQDARRRQEQIQAMPL---ADSQAVREQLRQEQALLEE--------- 1257

Query: 264  AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE 323
              I+   E+    ++ AKQ    I    LQ      Q E         K+   +   +QE
Sbjct: 1258 --IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1315

Query: 324  EADKKKQKREDMIREQKIYHKYLAQ--RREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
              D +    E +      Y K++++  RR EE+      +R+ E+ +A++  E+  E+  
Sbjct: 1316 YVDLRTHYSE-LTTLTSQYIKFISETLRRMEEE------ERLAEQQRAEE-RERLAEVEA 1367

Query: 382  EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
              E +RQL +        Q + + +REAKE ++R  E+                   RR+
Sbjct: 1368 ALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEE-----------------VVRRE 1405

Query: 442  RL---AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
                 AQ+ ++ +Q ++   +QS EAE + K R+ EA
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 120/517 (23%), Positives = 237/517 (45%), Gaps = 51/517 (9%)

Query: 2    YSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDR 61
            ++++   ++R ++     V  +R +  +    +   ER R   ++       +K++E  R
Sbjct: 1589 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW-QLKANEALR 1647

Query: 62   LKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLA----LEENEYFTEMQ 117
            L+ + ++    K L      + K+  +        RR K  E       L E E   + Q
Sbjct: 1648 LRLQAEEVAQQKSLAQAEAEKQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQ 1703

Query: 118  LKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRERC------EELRVELLS 170
            L + T +++    +E  +L  E  + E+Q   + E+L +  RE        +EL  EL  
Sbjct: 1704 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1763

Query: 171  IH-QKKVCEERKAQIA----FNEELSRQKL-VEEQMFSKLWEEDRLAKEKREAQEARRQK 224
            +  + +V    KA+         E S+Q+L  E   F +L EE   A+ +  A+EA+RQ+
Sbjct: 1764 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE--AARLRALAEEAKRQR 1821

Query: 225  ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQET 284
            +L E           + + + +A ++L E+ A + E+   ++K E E  + +K+   +  
Sbjct: 1822 QLAEED---------AARQRAEAERVLAEKLAAIGEAT--RLKTEAEIALKEKEAENERL 1870

Query: 285  RTILQKALQERIEHIQQEYRDEQDLNMKLVQ-RALQDLQEEADKKKQKREDMIREQK-IY 342
            R + +    +R    +Q  + + D+  +L Q R   D   E +++K   ED +R+++ + 
Sbjct: 1871 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVE 1928

Query: 343  HKYLAQRREEEKAQEKEFDRILEEDKAKKLAE----KDKELRLEKEARRQLVDEVMCTRK 398
             + LA +   EKA   + +  LE  + +  AE      ++  LE   +RQL  E    R+
Sbjct: 1929 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE-RRR 1987

Query: 399  LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM-QIAY 457
             + +E++Q+    +EE A ++K   E ++ L  + +E    R+R  QE  +QLQ+ Q A 
Sbjct: 1988 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2047

Query: 458  QQQSQEAEK------EEKRREFEAGVAANKMCLDKVQ 488
            Q++ Q  EK      ++K +E +  +   +  LD+++
Sbjct: 2048 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2084



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 121/487 (24%), Positives = 226/487 (46%), Gaps = 49/487 (10%)

Query: 34   EHHLERIRRSHQKHNAILASIKSSERDRLKAEWD----QHNDCKILDSLVRARIKDAVQG 89
            E  L + R+  ++  A+ AS + +   + + E +    + N    L S  +A ++ A Q 
Sbjct: 1918 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1977

Query: 90   FIINIEERRNK-----LRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE 144
             +   EERR +     +++ LA EE E   + +   E +E  K ++ E+ + L+E+ E+E
Sbjct: 1978 QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKV-EEARRLRERAEQE 2035

Query: 145  --RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS 202
              RQ  +A++  Q+ R + EE +    ++ QK+  +E +  +   + +  Q   E +   
Sbjct: 2036 SARQLQLAQEAAQK-RLQAEE-KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAAR 2091

Query: 203  KLWEEDRLAK--EKREAQEARRQKELMENTRLGLNAQITS-IKAQRQATQLLKEEE---A 256
            +  EE   A+   +REA ++RRQ E  E  +     Q  +  +AQ  A +L KE E   A
Sbjct: 2092 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2151

Query: 257  RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
            R  ++  A ++ +   D   ++  K   +T+ QKA  E+     +   +E D    L+  
Sbjct: 2152 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2211

Query: 317  ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
             LQ L+ EA +  ++R  +  E       L   R + +   K   RI  E++A  L +KD
Sbjct: 2212 ELQRLKAEATEAARQRSQVEEE-------LFSVRVQMEELSKLKARIEAENRALILRDKD 2264

Query: 377  KELRL---EKEARRQLVDEVM-CTRKLQVQEKLQREAKEQ--EERAMEQKHINESLK--- 427
               R    E E  +Q+ +E    +   Q   +L++ A+E   ++RA+ +K + E ++   
Sbjct: 2265 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2324

Query: 428  ---------ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQS-QEAEKEEKRREFEAGV 477
                     EL  ++KE    + R  QE ++Q+  Q+A + Q  Q   + E++R+ E   
Sbjct: 2325 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2384

Query: 478  AANKMCL 484
             A ++ L
Sbjct: 2385 EAERLKL 2391



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 110/422 (26%), Positives = 192/422 (45%), Gaps = 53/422 (12%)

Query: 96   ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
            E   +L E    EE E   E+    E   EK+ ++ E     K + E+E     A++L Q
Sbjct: 1349 EEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQAKAQAERE-----AKELQQ 1399

Query: 156  QFRE---RCEELRVELLSIHQKKVCEERKAQIAFNEEL-----SRQKLVEEQMFSKLWEE 207
            + +E   R EE  V+  +  QK+  +E   Q+  + E      +RQ    E+   ++ EE
Sbjct: 1400 RMQEEVVRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1457

Query: 208  DRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK 267
             R+ + + EA E  RQ+   E     L A+    +AQ++  Q   E   R V+ + +Q K
Sbjct: 1458 IRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ-DESQRK 1514

Query: 268  HENEQDMLKKQKAKQETRTILQKALQE------RIEHIQQEYRDEQDLNMKLVQRALQDL 321
             + E ++  + KA+ E     Q+ALQ       + E  ++  R  +    + VQ AL+  
Sbjct: 1515 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1574

Query: 322  QEEADKKKQ--------KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
            Q  A+ + Q        K   + R  +  H  +AQ REE    E+   +  E ++A++ A
Sbjct: 1575 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRAQQQAEAERAREEA 1631

Query: 374  EKDKE---LRLEKEARRQLVDEVMCTRKLQVQ-------EKLQREAKEQ---EERAMEQK 420
            E++ E   L+  +  R +L  E +  +K   Q       E+ +REA+ +   EE+A+ Q+
Sbjct: 1632 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1691

Query: 421  HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAY-QQQSQEAEKEEKRREFEAGVAA 479
             + E   E   +  E  A+++  A++   +L+ +    +QQ Q  E+E  R + EA  A 
Sbjct: 1692 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1751

Query: 480  NK 481
             K
Sbjct: 1752 QK 1753



 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 115/542 (21%), Positives = 227/542 (41%), Gaps = 98/542 (18%)

Query: 33   AEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFII 92
            A+   ER+RR  Q  +      +     R+KAE +   +        + R   A++   +
Sbjct: 1496 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--------KQRALQALEELRL 1547

Query: 93   NIEERRNKLRELLALEENEYFTEMQLKKET--------IEEKKDRMREKTKLLKEKNEKE 144
              EE   +LR+     E E   ++Q+  ET        ++ K+    EKT  L+   ++E
Sbjct: 1548 QAEEAERRLRQA----EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1603

Query: 145  -------RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVE 197
                   R++       Q   ER  E     L   Q K  E  + ++   E   ++ L +
Sbjct: 1604 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1663

Query: 198  EQMFSKLWEEDRLAKEKREA------------QEARRQKELMENT---RLGLNAQITSIK 242
             +   +  E +R A+ + +A            QE  +Q++L E T   RL    ++  ++
Sbjct: 1664 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1723

Query: 243  AQ----RQATQLLKEEEARL-------------VESNNAQIKHENEQDMLKKQKAKQETR 285
            A+     Q  QLL+EE ARL             +E+  A+++ E E  +  K +A++E+R
Sbjct: 1724 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1783

Query: 286  TILQKALQE----------------RIEHIQQEYRDEQDLNMKLVQRALQDLQE------ 323
            +  +K+ Q                 R+  + +E + ++ L  +   R   + +       
Sbjct: 1784 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1843

Query: 324  ----EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA---KKLAEKD 376
                EA + K + E  ++E++  ++ L +  E+E  Q +  +    + KA   ++LA+  
Sbjct: 1844 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1903

Query: 377  KELRLEKEARRQLVDEVMCTRKLQVQEKL-------QREAKEQEERAMEQKHINESLKEL 429
            K    E E ++ LV++ +  R+ QV+E++       ++ A  + E  +E   I  + ++ 
Sbjct: 1904 KASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1962

Query: 430  --NCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKV 487
              + E+ E  A RQR      ++ + +   + Q   A +EE  R+ +A +   +    KV
Sbjct: 1963 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2022

Query: 488  QE 489
            +E
Sbjct: 2023 EE 2024



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 88/386 (22%), Positives = 183/386 (47%), Gaps = 21/386 (5%)

Query: 92   INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKN-EKERQDFVA 150
            I ++E+  +   L  L E+E F   +L+++  + K D      +L K  + E ERQ  + 
Sbjct: 1858 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1917

Query: 151  EKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSR-QKLVEEQMFSKLWEEDR 209
            E   +Q R+  EE+ + L +  +K    + + ++    EL R +   E+ + SK   E  
Sbjct: 1918 EDTLRQRRQVEEEI-LALKASFEKAAAGKAELEL----ELGRIRSNAEDTLRSKEQAELE 1972

Query: 210  LAKEKR-EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
             A++++  A+E RR++E  E  +  L A+  + + ++ A + ++  +A++ E+   +++ 
Sbjct: 1973 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR--RLRE 2030

Query: 269  ENEQDMLKKQKAKQETRTILQKALQ-ERIEHIQQEYRDEQDLNMKLVQR--ALQDLQEEA 325
              EQ+  ++ +  QE     QK LQ E   H     + EQ+L   L Q    L  L+ EA
Sbjct: 2031 RAEQESARQLQLAQEAA---QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2087

Query: 326  DKKKQKREDMIREQKIYHKYLAQRR----EEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
            +  ++  E+    +    +  AQ R    E E+ ++   ++     +A+  AEK ++   
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2147

Query: 382  EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
            ++ ARR   ++    +K     ++++  K  E+   ++  + + L  L  + +E   ++ 
Sbjct: 2148 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2207

Query: 442  RLAQE-YRKQLQMQIAYQQQSQEAEK 466
             L +E  R + +   A +Q+SQ  E+
Sbjct: 2208 LLDEELQRLKAEATEAARQRSQVEEE 2233



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 65/280 (23%), Positives = 143/280 (51%), Gaps = 29/280 (10%)

Query: 194  KLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKE 253
            K + E +  ++ EE+RLA+++R A+E  R  E+             +++ QRQ  +   +
Sbjct: 1339 KFISETL-RRMEEEERLAEQQR-AEERERLAEVE-----------AALEKQRQLAEAHAQ 1385

Query: 254  EEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKL 313
             +A+  E    +++   +++++++++A  + +   ++++QE ++ ++Q    E ++  K 
Sbjct: 1386 AKAQ-AEREAKELQQRMQEEVVRREEAAVDAQQ-QKRSIQEELQQLRQS--SEAEIQAKA 1441

Query: 314  VQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
             Q       E A++ + + E+ IR  ++  +   ++R   + + +      EE +A+K  
Sbjct: 1442 RQA------EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1495

Query: 374  EKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEE 433
             +++  RL    RRQ+ DE    RK Q + +L    K + E A E++   ++L+EL  + 
Sbjct: 1496 AQEEAERL----RRQVQDESQ--RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1549

Query: 434  KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
            +E   R ++   E  +Q+Q+ +   Q+S EAE + KR  F
Sbjct: 1550 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1589



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 112/526 (21%), Positives = 218/526 (41%), Gaps = 92/526 (17%)

Query: 41   RRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNK 100
            +RS  +       ++  E  +LKA  +  N   IL      R KD  Q F+    E+  +
Sbjct: 2226 QRSQVEEELFSVRVQMEELSKLKARIEAENRALIL------RDKDNTQRFLQEEAEKMKQ 2279

Query: 101  LRE--------------LLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQ 146
            + E              L  L E +   +  L ++ ++EK   ++E T+L  E    ++Q
Sbjct: 2280 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2339

Query: 147  DFVAEKLDQQFRERCEELRVELLSI---HQKKVCEERKAQIAFNEELSRQKL-VEEQMFS 202
              +A++  ++ +E  E++  +L       Q+ +  ER+ Q+  + E  R KL V E   +
Sbjct: 2340 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2399

Query: 203  KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQIT---SIKAQRQAT----------- 248
            +   E+   + +++A+E     E +  T L    ++T   +++ QRQ +           
Sbjct: 2400 QARAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2456

Query: 249  -QLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ------- 300
             +L +E+E    E+   Q+K E E   +++++  QET+ + Q  L E+   +Q       
Sbjct: 2457 AELEREKEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2515

Query: 301  ----------------QEYRDEQDLNMKLVQRALQDL---QEEADKKKQKREDMIR-EQK 340
                            Q+ R+EQ    + +++  Q L    EEA +++ + E+ +R +Q+
Sbjct: 2516 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2575

Query: 341  IYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKL- 399
               +   QRR++E+   +E  R+ E+    +L E+     L   +      +V  T+ L 
Sbjct: 2576 ELQQLEQQRRQQEELLAEENQRLREQ---LQLLEEQHRAAL-AHSEEVTASQVAATKTLP 2631

Query: 400  QVQEKLQREAKEQEER----AMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQI 455
              ++ L   A E E       + +K   + L+E      E     QRLAQ          
Sbjct: 2632 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQ---------- 2678

Query: 456  AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNI 501
             +    + A +E+ R   +   +   + L    E LS +  L + +
Sbjct: 2679 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL 2724



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 80/337 (23%), Positives = 143/337 (42%), Gaps = 63/337 (18%)

Query: 149  VAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
            V E+L Q+  ER  ++ VE       ++ E  +A +A       Q  V ++   +L  + 
Sbjct: 1163 VGERLQQRHGER--DVEVERWRERVAQLLERWQAVLA-------QTDVRQRELEQLGRQL 1213

Query: 209  RLAKEKREA-----QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNN 263
            R  +E  +      Q+ARR++E ++   L   A   +++ Q +  Q L EE         
Sbjct: 1214 RYYRESADPLGAWLQDARRRQEQIQAMPL---ADSQAVREQLRQEQALLEE--------- 1261

Query: 264  AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE 323
              I+   E+    ++ AKQ    I    LQ      Q E         K+   +   +QE
Sbjct: 1262 --IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1319

Query: 324  EADKKKQKREDMIREQKIYHKYLAQ--RREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
              D +    E +      Y K++++  RR EE+      +R+ E+ +A++  E+  E+  
Sbjct: 1320 YVDLRTHYSE-LTTLTSQYIKFISETLRRMEEE------ERLAEQQRAEE-RERLAEVEA 1371

Query: 382  EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
              E +RQL +        Q + + +REAKE ++R  E+                   RR+
Sbjct: 1372 ALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEE-----------------VVRRE 1409

Query: 442  RL---AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
                 AQ+ ++ +Q ++   +QS EAE + K R+ EA
Sbjct: 1410 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1446


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 120/517 (23%), Positives = 237/517 (45%), Gaps = 51/517 (9%)

Query: 2    YSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDR 61
            ++++   ++R ++     V  +R +  +    +   ER R   ++       +K++E  R
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW-QLKANEALR 1643

Query: 62   LKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLA----LEENEYFTEMQ 117
            L+ + ++    K L      + K+  +        RR K  E       L E E   + Q
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQ 1699

Query: 118  LKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRERC------EELRVELLS 170
            L + T +++    +E  +L  E  + E+Q   + E+L +  RE        +EL  EL  
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1759

Query: 171  IH-QKKVCEERKAQIA----FNEELSRQKL-VEEQMFSKLWEEDRLAKEKREAQEARRQK 224
            +  + +V    KA+         E S+Q+L  E   F +L EE   A+ +  A+EA+RQ+
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE--AARLRALAEEAKRQR 1817

Query: 225  ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQET 284
            +L E           + + + +A ++L E+ A + E+   ++K E E  + +K+   +  
Sbjct: 1818 QLAEED---------AARQRAEAERVLAEKLAAIGEAT--RLKTEAEIALKEKEAENERL 1866

Query: 285  RTILQKALQERIEHIQQEYRDEQDLNMKLVQ-RALQDLQEEADKKKQKREDMIREQK-IY 342
            R + +    +R    +Q  + + D+  +L Q R   D   E +++K   ED +R+++ + 
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVE 1924

Query: 343  HKYLAQRREEEKAQEKEFDRILEEDKAKKLAE----KDKELRLEKEARRQLVDEVMCTRK 398
             + LA +   EKA   + +  LE  + +  AE      ++  LE   +RQL  E    R+
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE-RRR 1983

Query: 399  LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM-QIAY 457
             + +E++Q+    +EE A ++K   E ++ L  + +E    R+R  QE  +QLQ+ Q A 
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043

Query: 458  QQQSQEAEK------EEKRREFEAGVAANKMCLDKVQ 488
            Q++ Q  EK      ++K +E +  +   +  LD+++
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 121/487 (24%), Positives = 226/487 (46%), Gaps = 49/487 (10%)

Query: 34   EHHLERIRRSHQKHNAILASIKSSERDRLKAEWD----QHNDCKILDSLVRARIKDAVQG 89
            E  L + R+  ++  A+ AS + +   + + E +    + N    L S  +A ++ A Q 
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973

Query: 90   FIINIEERRNK-----LRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE 144
             +   EERR +     +++ LA EE E   + +   E +E  K ++ E+ + L+E+ E+E
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKV-EEARRLRERAEQE 2031

Query: 145  --RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS 202
              RQ  +A++  Q+ R + EE +    ++ QK+  +E +  +   + +  Q   E +   
Sbjct: 2032 SARQLQLAQEAAQK-RLQAEE-KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAAR 2087

Query: 203  KLWEEDRLAK--EKREAQEARRQKELMENTRLGLNAQITS-IKAQRQATQLLKEEE---A 256
            +  EE   A+   +REA ++RRQ E  E  +     Q  +  +AQ  A +L KE E   A
Sbjct: 2088 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147

Query: 257  RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
            R  ++  A ++ +   D   ++  K   +T+ QKA  E+     +   +E D    L+  
Sbjct: 2148 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207

Query: 317  ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
             LQ L+ EA +  ++R  +  E       L   R + +   K   RI  E++A  L +KD
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEE-------LFSVRVQMEELSKLKARIEAENRALILRDKD 2260

Query: 377  KELRL---EKEARRQLVDEVM-CTRKLQVQEKLQREAKEQ--EERAMEQKHINESLK--- 427
               R    E E  +Q+ +E    +   Q   +L++ A+E   ++RA+ +K + E ++   
Sbjct: 2261 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320

Query: 428  ---------ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQS-QEAEKEEKRREFEAGV 477
                     EL  ++KE    + R  QE ++Q+  Q+A + Q  Q   + E++R+ E   
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380

Query: 478  AANKMCL 484
             A ++ L
Sbjct: 2381 EAERLKL 2387



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 110/422 (26%), Positives = 192/422 (45%), Gaps = 53/422 (12%)

Query: 96   ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
            E   +L E    EE E   E+    E   EK+ ++ E     K + E+E     A++L Q
Sbjct: 1345 EEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQAKAQAERE-----AKELQQ 1395

Query: 156  QFRE---RCEELRVELLSIHQKKVCEERKAQIAFNEEL-----SRQKLVEEQMFSKLWEE 207
            + +E   R EE  V+  +  QK+  +E   Q+  + E      +RQ    E+   ++ EE
Sbjct: 1396 RMQEEVVRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453

Query: 208  DRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK 267
             R+ + + EA E  RQ+   E     L A+    +AQ++  Q   E   R V+ + +Q K
Sbjct: 1454 IRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ-DESQRK 1510

Query: 268  HENEQDMLKKQKAKQETRTILQKALQE------RIEHIQQEYRDEQDLNMKLVQRALQDL 321
             + E ++  + KA+ E     Q+ALQ       + E  ++  R  +    + VQ AL+  
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570

Query: 322  QEEADKKKQ--------KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
            Q  A+ + Q        K   + R  +  H  +AQ REE    E+   +  E ++A++ A
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRAQQQAEAERAREEA 1627

Query: 374  EKDKE---LRLEKEARRQLVDEVMCTRKLQVQ-------EKLQREAKEQ---EERAMEQK 420
            E++ E   L+  +  R +L  E +  +K   Q       E+ +REA+ +   EE+A+ Q+
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1687

Query: 421  HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAY-QQQSQEAEKEEKRREFEAGVAA 479
             + E   E   +  E  A+++  A++   +L+ +    +QQ Q  E+E  R + EA  A 
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1747

Query: 480  NK 481
             K
Sbjct: 1748 QK 1749



 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 115/542 (21%), Positives = 227/542 (41%), Gaps = 98/542 (18%)

Query: 33   AEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFII 92
            A+   ER+RR  Q  +      +     R+KAE +   +        + R   A++   +
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--------KQRALQALEELRL 1543

Query: 93   NIEERRNKLRELLALEENEYFTEMQLKKET--------IEEKKDRMREKTKLLKEKNEKE 144
              EE   +LR+     E E   ++Q+  ET        ++ K+    EKT  L+   ++E
Sbjct: 1544 QAEEAERRLRQA----EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599

Query: 145  -------RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVE 197
                   R++       Q   ER  E     L   Q K  E  + ++   E   ++ L +
Sbjct: 1600 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1659

Query: 198  EQMFSKLWEEDRLAKEKREA------------QEARRQKELMENT---RLGLNAQITSIK 242
             +   +  E +R A+ + +A            QE  +Q++L E T   RL    ++  ++
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719

Query: 243  AQ----RQATQLLKEEEARL-------------VESNNAQIKHENEQDMLKKQKAKQETR 285
            A+     Q  QLL+EE ARL             +E+  A+++ E E  +  K +A++E+R
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779

Query: 286  TILQKALQE----------------RIEHIQQEYRDEQDLNMKLVQRALQDLQE------ 323
            +  +K+ Q                 R+  + +E + ++ L  +   R   + +       
Sbjct: 1780 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839

Query: 324  ----EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA---KKLAEKD 376
                EA + K + E  ++E++  ++ L +  E+E  Q +  +    + KA   ++LA+  
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899

Query: 377  KELRLEKEARRQLVDEVMCTRKLQVQEKL-------QREAKEQEERAMEQKHINESLKEL 429
            K    E E ++ LV++ +  R+ QV+E++       ++ A  + E  +E   I  + ++ 
Sbjct: 1900 KASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1958

Query: 430  --NCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKV 487
              + E+ E  A RQR      ++ + +   + Q   A +EE  R+ +A +   +    KV
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018

Query: 488  QE 489
            +E
Sbjct: 2019 EE 2020



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 88/386 (22%), Positives = 183/386 (47%), Gaps = 21/386 (5%)

Query: 92   INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKN-EKERQDFVA 150
            I ++E+  +   L  L E+E F   +L+++  + K D      +L K  + E ERQ  + 
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1913

Query: 151  EKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSR-QKLVEEQMFSKLWEEDR 209
            E   +Q R+  EE+ + L +  +K    + + ++    EL R +   E+ + SK   E  
Sbjct: 1914 EDTLRQRRQVEEEI-LALKASFEKAAAGKAELEL----ELGRIRSNAEDTLRSKEQAELE 1968

Query: 210  LAKEKR-EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
             A++++  A+E RR++E  E  +  L A+  + + ++ A + ++  +A++ E+   +++ 
Sbjct: 1969 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR--RLRE 2026

Query: 269  ENEQDMLKKQKAKQETRTILQKALQ-ERIEHIQQEYRDEQDLNMKLVQR--ALQDLQEEA 325
              EQ+  ++ +  QE     QK LQ E   H     + EQ+L   L Q    L  L+ EA
Sbjct: 2027 RAEQESARQLQLAQEAA---QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083

Query: 326  DKKKQKREDMIREQKIYHKYLAQRR----EEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
            +  ++  E+    +    +  AQ R    E E+ ++   ++     +A+  AEK ++   
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2143

Query: 382  EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
            ++ ARR   ++    +K     ++++  K  E+   ++  + + L  L  + +E   ++ 
Sbjct: 2144 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2203

Query: 442  RLAQE-YRKQLQMQIAYQQQSQEAEK 466
             L +E  R + +   A +Q+SQ  E+
Sbjct: 2204 LLDEELQRLKAEATEAARQRSQVEEE 2229



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 65/280 (23%), Positives = 143/280 (51%), Gaps = 29/280 (10%)

Query: 194  KLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKE 253
            K + E +  ++ EE+RLA+++R A+E  R  E+             +++ QRQ  +   +
Sbjct: 1335 KFISETL-RRMEEEERLAEQQR-AEERERLAEVE-----------AALEKQRQLAEAHAQ 1381

Query: 254  EEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKL 313
             +A+  E    +++   +++++++++A  + +   ++++QE ++ ++Q    E ++  K 
Sbjct: 1382 AKAQ-AEREAKELQQRMQEEVVRREEAAVDAQQ-QKRSIQEELQQLRQS--SEAEIQAKA 1437

Query: 314  VQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
             Q       E A++ + + E+ IR  ++  +   ++R   + + +      EE +A+K  
Sbjct: 1438 RQA------EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491

Query: 374  EKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEE 433
             +++  RL    RRQ+ DE    RK Q + +L    K + E A E++   ++L+EL  + 
Sbjct: 1492 AQEEAERL----RRQVQDESQ--RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1545

Query: 434  KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
            +E   R ++   E  +Q+Q+ +   Q+S EAE + KR  F
Sbjct: 1546 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 112/526 (21%), Positives = 218/526 (41%), Gaps = 92/526 (17%)

Query: 41   RRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNK 100
            +RS  +       ++  E  +LKA  +  N   IL      R KD  Q F+    E+  +
Sbjct: 2222 QRSQVEEELFSVRVQMEELSKLKARIEAENRALIL------RDKDNTQRFLQEEAEKMKQ 2275

Query: 101  LRE--------------LLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQ 146
            + E              L  L E +   +  L ++ ++EK   ++E T+L  E    ++Q
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335

Query: 147  DFVAEKLDQQFRERCEELRVELLSI---HQKKVCEERKAQIAFNEELSRQKL-VEEQMFS 202
              +A++  ++ +E  E++  +L       Q+ +  ER+ Q+  + E  R KL V E   +
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2395

Query: 203  KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQIT---SIKAQRQAT----------- 248
            +   E+   + +++A+E     E +  T L    ++T   +++ QRQ +           
Sbjct: 2396 QARAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2452

Query: 249  -QLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ------- 300
             +L +E+E    E+   Q+K E E   +++++  QET+ + Q  L E+   +Q       
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2511

Query: 301  ----------------QEYRDEQDLNMKLVQRALQDL---QEEADKKKQKREDMIR-EQK 340
                            Q+ R+EQ    + +++  Q L    EEA +++ + E+ +R +Q+
Sbjct: 2512 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2571

Query: 341  IYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKL- 399
               +   QRR++E+   +E  R+ E+    +L E+     L   +      +V  T+ L 
Sbjct: 2572 ELQQLEQQRRQQEELLAEENQRLREQ---LQLLEEQHRAAL-AHSEEVTASQVAATKTLP 2627

Query: 400  QVQEKLQREAKEQEER----AMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQI 455
              ++ L   A E E       + +K   + L+E      E     QRLAQ          
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQ---------- 2674

Query: 456  AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNI 501
             +    + A +E+ R   +   +   + L    E LS +  L + +
Sbjct: 2675 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL 2720



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 80/337 (23%), Positives = 143/337 (42%), Gaps = 63/337 (18%)

Query: 149  VAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
            V E+L Q+  ER  ++ VE       ++ E  +A +A       Q  V ++   +L  + 
Sbjct: 1159 VGERLQQRHGER--DVEVERWRERVAQLLERWQAVLA-------QTDVRQRELEQLGRQL 1209

Query: 209  RLAKEKREA-----QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNN 263
            R  +E  +      Q+ARR++E ++   L   A   +++ Q +  Q L EE         
Sbjct: 1210 RYYRESADPLGAWLQDARRRQEQIQAMPL---ADSQAVREQLRQEQALLEE--------- 1257

Query: 264  AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE 323
              I+   E+    ++ AKQ    I    LQ      Q E         K+   +   +QE
Sbjct: 1258 --IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1315

Query: 324  EADKKKQKREDMIREQKIYHKYLAQ--RREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
              D +    E +      Y K++++  RR EE+      +R+ E+ +A++  E+  E+  
Sbjct: 1316 YVDLRTHYSE-LTTLTSQYIKFISETLRRMEEE------ERLAEQQRAEE-RERLAEVEA 1367

Query: 382  EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
              E +RQL +        Q + + +REAKE ++R  E+                   RR+
Sbjct: 1368 ALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEE-----------------VVRRE 1405

Query: 442  RL---AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
                 AQ+ ++ +Q ++   +QS EAE + K R+ EA
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 120/517 (23%), Positives = 237/517 (45%), Gaps = 51/517 (9%)

Query: 2    YSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDR 61
            ++++   ++R ++     V  +R +  +    +   ER R   ++       +K++E  R
Sbjct: 1553 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW-QLKANEALR 1611

Query: 62   LKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLA----LEENEYFTEMQ 117
            L+ + ++    K L      + K+  +        RR K  E       L E E   + Q
Sbjct: 1612 LRLQAEEVAQQKSLAQAEAEKQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQ 1667

Query: 118  LKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRERC------EELRVELLS 170
            L + T +++    +E  +L  E  + E+Q   + E+L +  RE        +EL  EL  
Sbjct: 1668 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1727

Query: 171  IH-QKKVCEERKAQIA----FNEELSRQKL-VEEQMFSKLWEEDRLAKEKREAQEARRQK 224
            +  + +V    KA+         E S+Q+L  E   F +L EE   A+ +  A+EA+RQ+
Sbjct: 1728 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE--AARLRALAEEAKRQR 1785

Query: 225  ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQET 284
            +L E           + + + +A ++L E+ A + E+   ++K E E  + +K+   +  
Sbjct: 1786 QLAEED---------AARQRAEAERVLAEKLAAIGEAT--RLKTEAEIALKEKEAENERL 1834

Query: 285  RTILQKALQERIEHIQQEYRDEQDLNMKLVQ-RALQDLQEEADKKKQKREDMIREQK-IY 342
            R + +    +R    +Q  + + D+  +L Q R   D   E +++K   ED +R+++ + 
Sbjct: 1835 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVE 1892

Query: 343  HKYLAQRREEEKAQEKEFDRILEEDKAKKLAE----KDKELRLEKEARRQLVDEVMCTRK 398
             + LA +   EKA   + +  LE  + +  AE      ++  LE   +RQL  E    R+
Sbjct: 1893 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE-RRR 1951

Query: 399  LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM-QIAY 457
             + +E++Q+    +EE A ++K   E ++ L  + +E    R+R  QE  +QLQ+ Q A 
Sbjct: 1952 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2011

Query: 458  QQQSQEAEK------EEKRREFEAGVAANKMCLDKVQ 488
            Q++ Q  EK      ++K +E +  +   +  LD+++
Sbjct: 2012 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2048



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 121/487 (24%), Positives = 226/487 (46%), Gaps = 49/487 (10%)

Query: 34   EHHLERIRRSHQKHNAILASIKSSERDRLKAEWD----QHNDCKILDSLVRARIKDAVQG 89
            E  L + R+  ++  A+ AS + +   + + E +    + N    L S  +A ++ A Q 
Sbjct: 1882 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1941

Query: 90   FIINIEERRNK-----LRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE 144
             +   EERR +     +++ LA EE E   + +   E +E  K ++ E+ + L+E+ E+E
Sbjct: 1942 QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKV-EEARRLRERAEQE 1999

Query: 145  --RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS 202
              RQ  +A++  Q+ R + EE +    ++ QK+  +E +  +   + +  Q   E +   
Sbjct: 2000 SARQLQLAQEAAQK-RLQAEE-KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAAR 2055

Query: 203  KLWEEDRLAK--EKREAQEARRQKELMENTRLGLNAQITS-IKAQRQATQLLKEEE---A 256
            +  EE   A+   +REA ++RRQ E  E  +     Q  +  +AQ  A +L KE E   A
Sbjct: 2056 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2115

Query: 257  RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
            R  ++  A ++ +   D   ++  K   +T+ QKA  E+     +   +E D    L+  
Sbjct: 2116 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2175

Query: 317  ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
             LQ L+ EA +  ++R  +  E       L   R + +   K   RI  E++A  L +KD
Sbjct: 2176 ELQRLKAEATEAARQRSQVEEE-------LFSVRVQMEELSKLKARIEAENRALILRDKD 2228

Query: 377  KELRL---EKEARRQLVDEVM-CTRKLQVQEKLQREAKEQ--EERAMEQKHINESLK--- 427
               R    E E  +Q+ +E    +   Q   +L++ A+E   ++RA+ +K + E ++   
Sbjct: 2229 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2288

Query: 428  ---------ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQS-QEAEKEEKRREFEAGV 477
                     EL  ++KE    + R  QE ++Q+  Q+A + Q  Q   + E++R+ E   
Sbjct: 2289 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2348

Query: 478  AANKMCL 484
             A ++ L
Sbjct: 2349 EAERLKL 2355



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 110/422 (26%), Positives = 192/422 (45%), Gaps = 53/422 (12%)

Query: 96   ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
            E   +L E    EE E   E+    E   EK+ ++ E     K + E+E     A++L Q
Sbjct: 1313 EEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQAKAQAERE-----AKELQQ 1363

Query: 156  QFRE---RCEELRVELLSIHQKKVCEERKAQIAFNEEL-----SRQKLVEEQMFSKLWEE 207
            + +E   R EE  V+  +  QK+  +E   Q+  + E      +RQ    E+   ++ EE
Sbjct: 1364 RMQEEVVRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1421

Query: 208  DRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK 267
             R+ + + EA E  RQ+   E     L A+    +AQ++  Q   E   R V+ + +Q K
Sbjct: 1422 IRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ-DESQRK 1478

Query: 268  HENEQDMLKKQKAKQETRTILQKALQE------RIEHIQQEYRDEQDLNMKLVQRALQDL 321
             + E ++  + KA+ E     Q+ALQ       + E  ++  R  +    + VQ AL+  
Sbjct: 1479 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1538

Query: 322  QEEADKKKQ--------KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
            Q  A+ + Q        K   + R  +  H  +AQ REE    E+   +  E ++A++ A
Sbjct: 1539 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRAQQQAEAERAREEA 1595

Query: 374  EKDKE---LRLEKEARRQLVDEVMCTRKLQVQ-------EKLQREAKEQ---EERAMEQK 420
            E++ E   L+  +  R +L  E +  +K   Q       E+ +REA+ +   EE+A+ Q+
Sbjct: 1596 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1655

Query: 421  HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAY-QQQSQEAEKEEKRREFEAGVAA 479
             + E   E   +  E  A+++  A++   +L+ +    +QQ Q  E+E  R + EA  A 
Sbjct: 1656 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1715

Query: 480  NK 481
             K
Sbjct: 1716 QK 1717



 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 115/542 (21%), Positives = 227/542 (41%), Gaps = 98/542 (18%)

Query: 33   AEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFII 92
            A+   ER+RR  Q  +      +     R+KAE +   +        + R   A++   +
Sbjct: 1460 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--------KQRALQALEELRL 1511

Query: 93   NIEERRNKLRELLALEENEYFTEMQLKKET--------IEEKKDRMREKTKLLKEKNEKE 144
              EE   +LR+     E E   ++Q+  ET        ++ K+    EKT  L+   ++E
Sbjct: 1512 QAEEAERRLRQA----EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1567

Query: 145  -------RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVE 197
                   R++       Q   ER  E     L   Q K  E  + ++   E   ++ L +
Sbjct: 1568 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1627

Query: 198  EQMFSKLWEEDRLAKEKREA------------QEARRQKELMENT---RLGLNAQITSIK 242
             +   +  E +R A+ + +A            QE  +Q++L E T   RL    ++  ++
Sbjct: 1628 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1687

Query: 243  AQ----RQATQLLKEEEARL-------------VESNNAQIKHENEQDMLKKQKAKQETR 285
            A+     Q  QLL+EE ARL             +E+  A+++ E E  +  K +A++E+R
Sbjct: 1688 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1747

Query: 286  TILQKALQE----------------RIEHIQQEYRDEQDLNMKLVQRALQDLQE------ 323
            +  +K+ Q                 R+  + +E + ++ L  +   R   + +       
Sbjct: 1748 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1807

Query: 324  ----EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA---KKLAEKD 376
                EA + K + E  ++E++  ++ L +  E+E  Q +  +    + KA   ++LA+  
Sbjct: 1808 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1867

Query: 377  KELRLEKEARRQLVDEVMCTRKLQVQEKL-------QREAKEQEERAMEQKHINESLKEL 429
            K    E E ++ LV++ +  R+ QV+E++       ++ A  + E  +E   I  + ++ 
Sbjct: 1868 KASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1926

Query: 430  --NCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKV 487
              + E+ E  A RQR      ++ + +   + Q   A +EE  R+ +A +   +    KV
Sbjct: 1927 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1986

Query: 488  QE 489
            +E
Sbjct: 1987 EE 1988



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 88/386 (22%), Positives = 183/386 (47%), Gaps = 21/386 (5%)

Query: 92   INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKN-EKERQDFVA 150
            I ++E+  +   L  L E+E F   +L+++  + K D      +L K  + E ERQ  + 
Sbjct: 1822 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1881

Query: 151  EKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSR-QKLVEEQMFSKLWEEDR 209
            E   +Q R+  EE+ + L +  +K    + + ++    EL R +   E+ + SK   E  
Sbjct: 1882 EDTLRQRRQVEEEI-LALKASFEKAAAGKAELEL----ELGRIRSNAEDTLRSKEQAELE 1936

Query: 210  LAKEKR-EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
             A++++  A+E RR++E  E  +  L A+  + + ++ A + ++  +A++ E+   +++ 
Sbjct: 1937 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR--RLRE 1994

Query: 269  ENEQDMLKKQKAKQETRTILQKALQ-ERIEHIQQEYRDEQDLNMKLVQR--ALQDLQEEA 325
              EQ+  ++ +  QE     QK LQ E   H     + EQ+L   L Q    L  L+ EA
Sbjct: 1995 RAEQESARQLQLAQEAA---QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2051

Query: 326  DKKKQKREDMIREQKIYHKYLAQRR----EEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
            +  ++  E+    +    +  AQ R    E E+ ++   ++     +A+  AEK ++   
Sbjct: 2052 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2111

Query: 382  EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
            ++ ARR   ++    +K     ++++  K  E+   ++  + + L  L  + +E   ++ 
Sbjct: 2112 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2171

Query: 442  RLAQE-YRKQLQMQIAYQQQSQEAEK 466
             L +E  R + +   A +Q+SQ  E+
Sbjct: 2172 LLDEELQRLKAEATEAARQRSQVEEE 2197



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 65/280 (23%), Positives = 143/280 (51%), Gaps = 29/280 (10%)

Query: 194  KLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKE 253
            K + E +  ++ EE+RLA+++R A+E  R  E+             +++ QRQ  +   +
Sbjct: 1303 KFISETL-RRMEEEERLAEQQR-AEERERLAEVE-----------AALEKQRQLAEAHAQ 1349

Query: 254  EEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKL 313
             +A+  E    +++   +++++++++A  + +   ++++QE ++ ++Q    E ++  K 
Sbjct: 1350 AKAQ-AEREAKELQQRMQEEVVRREEAAVDAQQ-QKRSIQEELQQLRQS--SEAEIQAKA 1405

Query: 314  VQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
             Q       E A++ + + E+ IR  ++  +   ++R   + + +      EE +A+K  
Sbjct: 1406 RQA------EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1459

Query: 374  EKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEE 433
             +++  RL    RRQ+ DE    RK Q + +L    K + E A E++   ++L+EL  + 
Sbjct: 1460 AQEEAERL----RRQVQDESQ--RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1513

Query: 434  KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
            +E   R ++   E  +Q+Q+ +   Q+S EAE + KR  F
Sbjct: 1514 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1553



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 112/526 (21%), Positives = 218/526 (41%), Gaps = 92/526 (17%)

Query: 41   RRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNK 100
            +RS  +       ++  E  +LKA  +  N   IL      R KD  Q F+    E+  +
Sbjct: 2190 QRSQVEEELFSVRVQMEELSKLKARIEAENRALIL------RDKDNTQRFLQEEAEKMKQ 2243

Query: 101  LRE--------------LLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQ 146
            + E              L  L E +   +  L ++ ++EK   ++E T+L  E    ++Q
Sbjct: 2244 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2303

Query: 147  DFVAEKLDQQFRERCEELRVELLSI---HQKKVCEERKAQIAFNEELSRQKL-VEEQMFS 202
              +A++  ++ +E  E++  +L       Q+ +  ER+ Q+  + E  R KL V E   +
Sbjct: 2304 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2363

Query: 203  KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQIT---SIKAQRQAT----------- 248
            +   E+   + +++A+E     E +  T L    ++T   +++ QRQ +           
Sbjct: 2364 QARAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2420

Query: 249  -QLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ------- 300
             +L +E+E    E+   Q+K E E   +++++  QET+ + Q  L E+   +Q       
Sbjct: 2421 AELEREKEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2479

Query: 301  ----------------QEYRDEQDLNMKLVQRALQDL---QEEADKKKQKREDMIR-EQK 340
                            Q+ R+EQ    + +++  Q L    EEA +++ + E+ +R +Q+
Sbjct: 2480 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2539

Query: 341  IYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKL- 399
               +   QRR++E+   +E  R+ E+    +L E+     L   +      +V  T+ L 
Sbjct: 2540 ELQQLEQQRRQQEELLAEENQRLREQ---LQLLEEQHRAAL-AHSEEVTASQVAATKTLP 2595

Query: 400  QVQEKLQREAKEQEER----AMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQI 455
              ++ L   A E E       + +K   + L+E      E     QRLAQ          
Sbjct: 2596 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQ---------- 2642

Query: 456  AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNI 501
             +    + A +E+ R   +   +   + L    E LS +  L + +
Sbjct: 2643 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL 2688



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 80/337 (23%), Positives = 143/337 (42%), Gaps = 63/337 (18%)

Query: 149  VAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
            V E+L Q+  ER  ++ VE       ++ E  +A +A       Q  V ++   +L  + 
Sbjct: 1127 VGERLQQRHGER--DVEVERWRERVAQLLERWQAVLA-------QTDVRQRELEQLGRQL 1177

Query: 209  RLAKEKREA-----QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNN 263
            R  +E  +      Q+ARR++E ++   L   A   +++ Q +  Q L EE         
Sbjct: 1178 RYYRESADPLGAWLQDARRRQEQIQAMPL---ADSQAVREQLRQEQALLEE--------- 1225

Query: 264  AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE 323
              I+   E+    ++ AKQ    I    LQ      Q E         K+   +   +QE
Sbjct: 1226 --IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1283

Query: 324  EADKKKQKREDMIREQKIYHKYLAQ--RREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
              D +    E +      Y K++++  RR EE+      +R+ E+ +A++  E+  E+  
Sbjct: 1284 YVDLRTHYSE-LTTLTSQYIKFISETLRRMEEE------ERLAEQQRAEE-RERLAEVEA 1335

Query: 382  EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
              E +RQL +        Q + + +REAKE ++R  E+                   RR+
Sbjct: 1336 ALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEE-----------------VVRRE 1373

Query: 442  RL---AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
                 AQ+ ++ +Q ++   +QS EAE + K R+ EA
Sbjct: 1374 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1410


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 120/517 (23%), Positives = 237/517 (45%), Gaps = 51/517 (9%)

Query: 2    YSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDR 61
            ++++   ++R ++     V  +R +  +    +   ER R   ++       +K++E  R
Sbjct: 1722 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW-QLKANEALR 1780

Query: 62   LKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLA----LEENEYFTEMQ 117
            L+ + ++    K L      + K+  +        RR K  E       L E E   + Q
Sbjct: 1781 LRLQAEEVAQQKSLAQAEAEKQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQ 1836

Query: 118  LKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRERC------EELRVELLS 170
            L + T +++    +E  +L  E  + E+Q   + E+L +  RE        +EL  EL  
Sbjct: 1837 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1896

Query: 171  IH-QKKVCEERKAQIA----FNEELSRQKL-VEEQMFSKLWEEDRLAKEKREAQEARRQK 224
            +  + +V    KA+         E S+Q+L  E   F +L EE   A+ +  A+EA+RQ+
Sbjct: 1897 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE--AARLRALAEEAKRQR 1954

Query: 225  ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQET 284
            +L E           + + + +A ++L E+ A + E+   ++K E E  + +K+   +  
Sbjct: 1955 QLAEED---------AARQRAEAERVLAEKLAAIGEAT--RLKTEAEIALKEKEAENERL 2003

Query: 285  RTILQKALQERIEHIQQEYRDEQDLNMKLVQ-RALQDLQEEADKKKQKREDMIREQK-IY 342
            R + +    +R    +Q  + + D+  +L Q R   D   E +++K   ED +R+++ + 
Sbjct: 2004 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVE 2061

Query: 343  HKYLAQRREEEKAQEKEFDRILEEDKAKKLAE----KDKELRLEKEARRQLVDEVMCTRK 398
             + LA +   EKA   + +  LE  + +  AE      ++  LE   +RQL  E    R+
Sbjct: 2062 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE-RRR 2120

Query: 399  LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM-QIAY 457
             + +E++Q+    +EE A ++K   E ++ L  + +E    R+R  QE  +QLQ+ Q A 
Sbjct: 2121 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2180

Query: 458  QQQSQEAEK------EEKRREFEAGVAANKMCLDKVQ 488
            Q++ Q  EK      ++K +E +  +   +  LD+++
Sbjct: 2181 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2217



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 121/487 (24%), Positives = 226/487 (46%), Gaps = 49/487 (10%)

Query: 34   EHHLERIRRSHQKHNAILASIKSSERDRLKAEWD----QHNDCKILDSLVRARIKDAVQG 89
            E  L + R+  ++  A+ AS + +   + + E +    + N    L S  +A ++ A Q 
Sbjct: 2051 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2110

Query: 90   FIINIEERRNK-----LRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE 144
             +   EERR +     +++ LA EE E   + +   E +E  K ++ E+ + L+E+ E+E
Sbjct: 2111 QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKV-EEARRLRERAEQE 2168

Query: 145  --RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS 202
              RQ  +A++  Q+ R + EE +    ++ QK+  +E +  +   + +  Q   E +   
Sbjct: 2169 SARQLQLAQEAAQK-RLQAEE-KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAAR 2224

Query: 203  KLWEEDRLAK--EKREAQEARRQKELMENTRLGLNAQITS-IKAQRQATQLLKEEE---A 256
            +  EE   A+   +REA ++RRQ E  E  +     Q  +  +AQ  A +L KE E   A
Sbjct: 2225 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2284

Query: 257  RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
            R  ++  A ++ +   D   ++  K   +T+ QKA  E+     +   +E D    L+  
Sbjct: 2285 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2344

Query: 317  ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
             LQ L+ EA +  ++R  +  E       L   R + +   K   RI  E++A  L +KD
Sbjct: 2345 ELQRLKAEATEAARQRSQVEEE-------LFSVRVQMEELSKLKARIEAENRALILRDKD 2397

Query: 377  KELRL---EKEARRQLVDEVM-CTRKLQVQEKLQREAKEQ--EERAMEQKHINESLK--- 427
               R    E E  +Q+ +E    +   Q   +L++ A+E   ++RA+ +K + E ++   
Sbjct: 2398 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2457

Query: 428  ---------ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQS-QEAEKEEKRREFEAGV 477
                     EL  ++KE    + R  QE ++Q+  Q+A + Q  Q   + E++R+ E   
Sbjct: 2458 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2517

Query: 478  AANKMCL 484
             A ++ L
Sbjct: 2518 EAERLKL 2524



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 110/422 (26%), Positives = 192/422 (45%), Gaps = 53/422 (12%)

Query: 96   ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
            E   +L E    EE E   E+    E   EK+ ++ E     K + E+E     A++L Q
Sbjct: 1482 EEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQAKAQAERE-----AKELQQ 1532

Query: 156  QFRE---RCEELRVELLSIHQKKVCEERKAQIAFNEEL-----SRQKLVEEQMFSKLWEE 207
            + +E   R EE  V+  +  QK+  +E   Q+  + E      +RQ    E+   ++ EE
Sbjct: 1533 RMQEEVVRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1590

Query: 208  DRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK 267
             R+ + + EA E  RQ+   E     L A+    +AQ++  Q   E   R V+ + +Q K
Sbjct: 1591 IRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ-DESQRK 1647

Query: 268  HENEQDMLKKQKAKQETRTILQKALQE------RIEHIQQEYRDEQDLNMKLVQRALQDL 321
             + E ++  + KA+ E     Q+ALQ       + E  ++  R  +    + VQ AL+  
Sbjct: 1648 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1707

Query: 322  QEEADKKKQ--------KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
            Q  A+ + Q        K   + R  +  H  +AQ REE    E+   +  E ++A++ A
Sbjct: 1708 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRAQQQAEAERAREEA 1764

Query: 374  EKDKE---LRLEKEARRQLVDEVMCTRKLQVQ-------EKLQREAKEQ---EERAMEQK 420
            E++ E   L+  +  R +L  E +  +K   Q       E+ +REA+ +   EE+A+ Q+
Sbjct: 1765 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1824

Query: 421  HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAY-QQQSQEAEKEEKRREFEAGVAA 479
             + E   E   +  E  A+++  A++   +L+ +    +QQ Q  E+E  R + EA  A 
Sbjct: 1825 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1884

Query: 480  NK 481
             K
Sbjct: 1885 QK 1886



 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 115/542 (21%), Positives = 227/542 (41%), Gaps = 98/542 (18%)

Query: 33   AEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFII 92
            A+   ER+RR  Q  +      +     R+KAE +   +        + R   A++   +
Sbjct: 1629 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--------KQRALQALEELRL 1680

Query: 93   NIEERRNKLRELLALEENEYFTEMQLKKET--------IEEKKDRMREKTKLLKEKNEKE 144
              EE   +LR+     E E   ++Q+  ET        ++ K+    EKT  L+   ++E
Sbjct: 1681 QAEEAERRLRQA----EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1736

Query: 145  -------RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVE 197
                   R++       Q   ER  E     L   Q K  E  + ++   E   ++ L +
Sbjct: 1737 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1796

Query: 198  EQMFSKLWEEDRLAKEKREA------------QEARRQKELMENT---RLGLNAQITSIK 242
             +   +  E +R A+ + +A            QE  +Q++L E T   RL    ++  ++
Sbjct: 1797 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1856

Query: 243  AQ----RQATQLLKEEEARL-------------VESNNAQIKHENEQDMLKKQKAKQETR 285
            A+     Q  QLL+EE ARL             +E+  A+++ E E  +  K +A++E+R
Sbjct: 1857 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916

Query: 286  TILQKALQE----------------RIEHIQQEYRDEQDLNMKLVQRALQDLQE------ 323
            +  +K+ Q                 R+  + +E + ++ L  +   R   + +       
Sbjct: 1917 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1976

Query: 324  ----EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA---KKLAEKD 376
                EA + K + E  ++E++  ++ L +  E+E  Q +  +    + KA   ++LA+  
Sbjct: 1977 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 2036

Query: 377  KELRLEKEARRQLVDEVMCTRKLQVQEKL-------QREAKEQEERAMEQKHINESLKEL 429
            K    E E ++ LV++ +  R+ QV+E++       ++ A  + E  +E   I  + ++ 
Sbjct: 2037 KASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 2095

Query: 430  --NCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKV 487
              + E+ E  A RQR      ++ + +   + Q   A +EE  R+ +A +   +    KV
Sbjct: 2096 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2155

Query: 488  QE 489
            +E
Sbjct: 2156 EE 2157



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 88/386 (22%), Positives = 183/386 (47%), Gaps = 21/386 (5%)

Query: 92   INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKN-EKERQDFVA 150
            I ++E+  +   L  L E+E F   +L+++  + K D      +L K  + E ERQ  + 
Sbjct: 1991 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 2050

Query: 151  EKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSR-QKLVEEQMFSKLWEEDR 209
            E   +Q R+  EE+ + L +  +K    + + ++    EL R +   E+ + SK   E  
Sbjct: 2051 EDTLRQRRQVEEEI-LALKASFEKAAAGKAELEL----ELGRIRSNAEDTLRSKEQAELE 2105

Query: 210  LAKEKR-EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
             A++++  A+E RR++E  E  +  L A+  + + ++ A + ++  +A++ E+   +++ 
Sbjct: 2106 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR--RLRE 2163

Query: 269  ENEQDMLKKQKAKQETRTILQKALQ-ERIEHIQQEYRDEQDLNMKLVQR--ALQDLQEEA 325
              EQ+  ++ +  QE     QK LQ E   H     + EQ+L   L Q    L  L+ EA
Sbjct: 2164 RAEQESARQLQLAQEAA---QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220

Query: 326  DKKKQKREDMIREQKIYHKYLAQRR----EEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
            +  ++  E+    +    +  AQ R    E E+ ++   ++     +A+  AEK ++   
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2280

Query: 382  EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
            ++ ARR   ++    +K     ++++  K  E+   ++  + + L  L  + +E   ++ 
Sbjct: 2281 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2340

Query: 442  RLAQE-YRKQLQMQIAYQQQSQEAEK 466
             L +E  R + +   A +Q+SQ  E+
Sbjct: 2341 LLDEELQRLKAEATEAARQRSQVEEE 2366



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 65/280 (23%), Positives = 143/280 (51%), Gaps = 29/280 (10%)

Query: 194  KLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKE 253
            K + E +  ++ EE+RLA+++R A+E  R  E+             +++ QRQ  +   +
Sbjct: 1472 KFISETL-RRMEEEERLAEQQR-AEERERLAEVE-----------AALEKQRQLAEAHAQ 1518

Query: 254  EEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKL 313
             +A+  E    +++   +++++++++A  + +   ++++QE ++ ++Q    E ++  K 
Sbjct: 1519 AKAQ-AEREAKELQQRMQEEVVRREEAAVDAQQ-QKRSIQEELQQLRQS--SEAEIQAKA 1574

Query: 314  VQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
             Q       E A++ + + E+ IR  ++  +   ++R   + + +      EE +A+K  
Sbjct: 1575 RQA------EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1628

Query: 374  EKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEE 433
             +++  RL    RRQ+ DE    RK Q + +L    K + E A E++   ++L+EL  + 
Sbjct: 1629 AQEEAERL----RRQVQDESQ--RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1682

Query: 434  KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
            +E   R ++   E  +Q+Q+ +   Q+S EAE + KR  F
Sbjct: 1683 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1722



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 112/526 (21%), Positives = 218/526 (41%), Gaps = 92/526 (17%)

Query: 41   RRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNK 100
            +RS  +       ++  E  +LKA  +  N   IL      R KD  Q F+    E+  +
Sbjct: 2359 QRSQVEEELFSVRVQMEELSKLKARIEAENRALIL------RDKDNTQRFLQEEAEKMKQ 2412

Query: 101  LRE--------------LLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQ 146
            + E              L  L E +   +  L ++ ++EK   ++E T+L  E    ++Q
Sbjct: 2413 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2472

Query: 147  DFVAEKLDQQFRERCEELRVELLSI---HQKKVCEERKAQIAFNEELSRQKL-VEEQMFS 202
              +A++  ++ +E  E++  +L       Q+ +  ER+ Q+  + E  R KL V E   +
Sbjct: 2473 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2532

Query: 203  KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQIT---SIKAQRQAT----------- 248
            +   E+   + +++A+E     E +  T L    ++T   +++ QRQ +           
Sbjct: 2533 QARAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2589

Query: 249  -QLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ------- 300
             +L +E+E    E+   Q+K E E   +++++  QET+ + Q  L E+   +Q       
Sbjct: 2590 AELEREKEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2648

Query: 301  ----------------QEYRDEQDLNMKLVQRALQDL---QEEADKKKQKREDMIR-EQK 340
                            Q+ R+EQ    + +++  Q L    EEA +++ + E+ +R +Q+
Sbjct: 2649 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2708

Query: 341  IYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKL- 399
               +   QRR++E+   +E  R+ E+    +L E+     L   +      +V  T+ L 
Sbjct: 2709 ELQQLEQQRRQQEELLAEENQRLREQ---LQLLEEQHRAAL-AHSEEVTASQVAATKTLP 2764

Query: 400  QVQEKLQREAKEQEER----AMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQI 455
              ++ L   A E E       + +K   + L+E      E     QRLAQ          
Sbjct: 2765 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQ---------- 2811

Query: 456  AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNI 501
             +    + A +E+ R   +   +   + L    E LS +  L + +
Sbjct: 2812 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL 2857



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 80/337 (23%), Positives = 143/337 (42%), Gaps = 63/337 (18%)

Query: 149  VAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
            V E+L Q+  ER  ++ VE       ++ E  +A +A       Q  V ++   +L  + 
Sbjct: 1296 VGERLQQRHGER--DVEVERWRERVAQLLERWQAVLA-------QTDVRQRELEQLGRQL 1346

Query: 209  RLAKEKREA-----QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNN 263
            R  +E  +      Q+ARR++E ++   L   A   +++ Q +  Q L EE         
Sbjct: 1347 RYYRESADPLGAWLQDARRRQEQIQAMPL---ADSQAVREQLRQEQALLEE--------- 1394

Query: 264  AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE 323
              I+   E+    ++ AKQ    I    LQ      Q E         K+   +   +QE
Sbjct: 1395 --IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1452

Query: 324  EADKKKQKREDMIREQKIYHKYLAQ--RREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
              D +    E +      Y K++++  RR EE+      +R+ E+ +A++  E+  E+  
Sbjct: 1453 YVDLRTHYSE-LTTLTSQYIKFISETLRRMEEE------ERLAEQQRAEE-RERLAEVEA 1504

Query: 382  EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
              E +RQL +        Q + + +REAKE ++R  E+                   RR+
Sbjct: 1505 ALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEE-----------------VVRRE 1542

Query: 442  RL---AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
                 AQ+ ++ +Q ++   +QS EAE + K R+ EA
Sbjct: 1543 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1579


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 120/517 (23%), Positives = 237/517 (45%), Gaps = 51/517 (9%)

Query: 2    YSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDR 61
            ++++   ++R ++     V  +R +  +    +   ER R   ++       +K++E  R
Sbjct: 1563 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW-QLKANEALR 1621

Query: 62   LKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLA----LEENEYFTEMQ 117
            L+ + ++    K L      + K+  +        RR K  E       L E E   + Q
Sbjct: 1622 LRLQAEEVAQQKSLAQAEAEKQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQ 1677

Query: 118  LKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRERC------EELRVELLS 170
            L + T +++    +E  +L  E  + E+Q   + E+L +  RE        +EL  EL  
Sbjct: 1678 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1737

Query: 171  IH-QKKVCEERKAQIA----FNEELSRQKL-VEEQMFSKLWEEDRLAKEKREAQEARRQK 224
            +  + +V    KA+         E S+Q+L  E   F +L EE   A+ +  A+EA+RQ+
Sbjct: 1738 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE--AARLRALAEEAKRQR 1795

Query: 225  ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQET 284
            +L E           + + + +A ++L E+ A + E+   ++K E E  + +K+   +  
Sbjct: 1796 QLAEED---------AARQRAEAERVLAEKLAAIGEAT--RLKTEAEIALKEKEAENERL 1844

Query: 285  RTILQKALQERIEHIQQEYRDEQDLNMKLVQ-RALQDLQEEADKKKQKREDMIREQK-IY 342
            R + +    +R    +Q  + + D+  +L Q R   D   E +++K   ED +R+++ + 
Sbjct: 1845 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVE 1902

Query: 343  HKYLAQRREEEKAQEKEFDRILEEDKAKKLAE----KDKELRLEKEARRQLVDEVMCTRK 398
             + LA +   EKA   + +  LE  + +  AE      ++  LE   +RQL  E    R+
Sbjct: 1903 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE-RRR 1961

Query: 399  LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM-QIAY 457
             + +E++Q+    +EE A ++K   E ++ L  + +E    R+R  QE  +QLQ+ Q A 
Sbjct: 1962 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2021

Query: 458  QQQSQEAEK------EEKRREFEAGVAANKMCLDKVQ 488
            Q++ Q  EK      ++K +E +  +   +  LD+++
Sbjct: 2022 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2058



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 121/487 (24%), Positives = 226/487 (46%), Gaps = 49/487 (10%)

Query: 34   EHHLERIRRSHQKHNAILASIKSSERDRLKAEWD----QHNDCKILDSLVRARIKDAVQG 89
            E  L + R+  ++  A+ AS + +   + + E +    + N    L S  +A ++ A Q 
Sbjct: 1892 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1951

Query: 90   FIINIEERRNK-----LRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE 144
             +   EERR +     +++ LA EE E   + +   E +E  K ++ E+ + L+E+ E+E
Sbjct: 1952 QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKV-EEARRLRERAEQE 2009

Query: 145  --RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS 202
              RQ  +A++  Q+ R + EE +    ++ QK+  +E +  +   + +  Q   E +   
Sbjct: 2010 SARQLQLAQEAAQK-RLQAEE-KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAAR 2065

Query: 203  KLWEEDRLAK--EKREAQEARRQKELMENTRLGLNAQITS-IKAQRQATQLLKEEE---A 256
            +  EE   A+   +REA ++RRQ E  E  +     Q  +  +AQ  A +L KE E   A
Sbjct: 2066 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2125

Query: 257  RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
            R  ++  A ++ +   D   ++  K   +T+ QKA  E+     +   +E D    L+  
Sbjct: 2126 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2185

Query: 317  ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
             LQ L+ EA +  ++R  +  E       L   R + +   K   RI  E++A  L +KD
Sbjct: 2186 ELQRLKAEATEAARQRSQVEEE-------LFSVRVQMEELSKLKARIEAENRALILRDKD 2238

Query: 377  KELRL---EKEARRQLVDEVM-CTRKLQVQEKLQREAKEQ--EERAMEQKHINESLK--- 427
               R    E E  +Q+ +E    +   Q   +L++ A+E   ++RA+ +K + E ++   
Sbjct: 2239 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2298

Query: 428  ---------ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQS-QEAEKEEKRREFEAGV 477
                     EL  ++KE    + R  QE ++Q+  Q+A + Q  Q   + E++R+ E   
Sbjct: 2299 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2358

Query: 478  AANKMCL 484
             A ++ L
Sbjct: 2359 EAERLKL 2365



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 110/422 (26%), Positives = 192/422 (45%), Gaps = 53/422 (12%)

Query: 96   ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
            E   +L E    EE E   E+    E   EK+ ++ E     K + E+E     A++L Q
Sbjct: 1323 EEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQAKAQAERE-----AKELQQ 1373

Query: 156  QFRE---RCEELRVELLSIHQKKVCEERKAQIAFNEEL-----SRQKLVEEQMFSKLWEE 207
            + +E   R EE  V+  +  QK+  +E   Q+  + E      +RQ    E+   ++ EE
Sbjct: 1374 RMQEEVVRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1431

Query: 208  DRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK 267
             R+ + + EA E  RQ+   E     L A+    +AQ++  Q   E   R V+ + +Q K
Sbjct: 1432 IRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ-DESQRK 1488

Query: 268  HENEQDMLKKQKAKQETRTILQKALQE------RIEHIQQEYRDEQDLNMKLVQRALQDL 321
             + E ++  + KA+ E     Q+ALQ       + E  ++  R  +    + VQ AL+  
Sbjct: 1489 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1548

Query: 322  QEEADKKKQ--------KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
            Q  A+ + Q        K   + R  +  H  +AQ REE    E+   +  E ++A++ A
Sbjct: 1549 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRAQQQAEAERAREEA 1605

Query: 374  EKDKE---LRLEKEARRQLVDEVMCTRKLQVQ-------EKLQREAKEQ---EERAMEQK 420
            E++ E   L+  +  R +L  E +  +K   Q       E+ +REA+ +   EE+A+ Q+
Sbjct: 1606 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1665

Query: 421  HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAY-QQQSQEAEKEEKRREFEAGVAA 479
             + E   E   +  E  A+++  A++   +L+ +    +QQ Q  E+E  R + EA  A 
Sbjct: 1666 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1725

Query: 480  NK 481
             K
Sbjct: 1726 QK 1727



 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 115/542 (21%), Positives = 227/542 (41%), Gaps = 98/542 (18%)

Query: 33   AEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFII 92
            A+   ER+RR  Q  +      +     R+KAE +   +        + R   A++   +
Sbjct: 1470 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--------KQRALQALEELRL 1521

Query: 93   NIEERRNKLRELLALEENEYFTEMQLKKET--------IEEKKDRMREKTKLLKEKNEKE 144
              EE   +LR+     E E   ++Q+  ET        ++ K+    EKT  L+   ++E
Sbjct: 1522 QAEEAERRLRQA----EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1577

Query: 145  -------RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVE 197
                   R++       Q   ER  E     L   Q K  E  + ++   E   ++ L +
Sbjct: 1578 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1637

Query: 198  EQMFSKLWEEDRLAKEKREA------------QEARRQKELMENT---RLGLNAQITSIK 242
             +   +  E +R A+ + +A            QE  +Q++L E T   RL    ++  ++
Sbjct: 1638 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1697

Query: 243  AQ----RQATQLLKEEEARL-------------VESNNAQIKHENEQDMLKKQKAKQETR 285
            A+     Q  QLL+EE ARL             +E+  A+++ E E  +  K +A++E+R
Sbjct: 1698 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757

Query: 286  TILQKALQE----------------RIEHIQQEYRDEQDLNMKLVQRALQDLQE------ 323
            +  +K+ Q                 R+  + +E + ++ L  +   R   + +       
Sbjct: 1758 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1817

Query: 324  ----EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA---KKLAEKD 376
                EA + K + E  ++E++  ++ L +  E+E  Q +  +    + KA   ++LA+  
Sbjct: 1818 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1877

Query: 377  KELRLEKEARRQLVDEVMCTRKLQVQEKL-------QREAKEQEERAMEQKHINESLKEL 429
            K    E E ++ LV++ +  R+ QV+E++       ++ A  + E  +E   I  + ++ 
Sbjct: 1878 KASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1936

Query: 430  --NCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKV 487
              + E+ E  A RQR      ++ + +   + Q   A +EE  R+ +A +   +    KV
Sbjct: 1937 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1996

Query: 488  QE 489
            +E
Sbjct: 1997 EE 1998



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 88/386 (22%), Positives = 183/386 (47%), Gaps = 21/386 (5%)

Query: 92   INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKN-EKERQDFVA 150
            I ++E+  +   L  L E+E F   +L+++  + K D      +L K  + E ERQ  + 
Sbjct: 1832 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1891

Query: 151  EKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSR-QKLVEEQMFSKLWEEDR 209
            E   +Q R+  EE+ + L +  +K    + + ++    EL R +   E+ + SK   E  
Sbjct: 1892 EDTLRQRRQVEEEI-LALKASFEKAAAGKAELEL----ELGRIRSNAEDTLRSKEQAELE 1946

Query: 210  LAKEKR-EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
             A++++  A+E RR++E  E  +  L A+  + + ++ A + ++  +A++ E+   +++ 
Sbjct: 1947 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR--RLRE 2004

Query: 269  ENEQDMLKKQKAKQETRTILQKALQ-ERIEHIQQEYRDEQDLNMKLVQR--ALQDLQEEA 325
              EQ+  ++ +  QE     QK LQ E   H     + EQ+L   L Q    L  L+ EA
Sbjct: 2005 RAEQESARQLQLAQEAA---QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2061

Query: 326  DKKKQKREDMIREQKIYHKYLAQRR----EEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
            +  ++  E+    +    +  AQ R    E E+ ++   ++     +A+  AEK ++   
Sbjct: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2121

Query: 382  EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
            ++ ARR   ++    +K     ++++  K  E+   ++  + + L  L  + +E   ++ 
Sbjct: 2122 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2181

Query: 442  RLAQE-YRKQLQMQIAYQQQSQEAEK 466
             L +E  R + +   A +Q+SQ  E+
Sbjct: 2182 LLDEELQRLKAEATEAARQRSQVEEE 2207



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 65/280 (23%), Positives = 143/280 (51%), Gaps = 29/280 (10%)

Query: 194  KLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKE 253
            K + E +  ++ EE+RLA+++R A+E  R  E+             +++ QRQ  +   +
Sbjct: 1313 KFISETL-RRMEEEERLAEQQR-AEERERLAEVE-----------AALEKQRQLAEAHAQ 1359

Query: 254  EEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKL 313
             +A+  E    +++   +++++++++A  + +   ++++QE ++ ++Q    E ++  K 
Sbjct: 1360 AKAQ-AEREAKELQQRMQEEVVRREEAAVDAQQ-QKRSIQEELQQLRQS--SEAEIQAKA 1415

Query: 314  VQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
             Q       E A++ + + E+ IR  ++  +   ++R   + + +      EE +A+K  
Sbjct: 1416 RQA------EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1469

Query: 374  EKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEE 433
             +++  RL    RRQ+ DE    RK Q + +L    K + E A E++   ++L+EL  + 
Sbjct: 1470 AQEEAERL----RRQVQDESQ--RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1523

Query: 434  KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
            +E   R ++   E  +Q+Q+ +   Q+S EAE + KR  F
Sbjct: 1524 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1563



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 112/526 (21%), Positives = 218/526 (41%), Gaps = 92/526 (17%)

Query: 41   RRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNK 100
            +RS  +       ++  E  +LKA  +  N   IL      R KD  Q F+    E+  +
Sbjct: 2200 QRSQVEEELFSVRVQMEELSKLKARIEAENRALIL------RDKDNTQRFLQEEAEKMKQ 2253

Query: 101  LRE--------------LLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQ 146
            + E              L  L E +   +  L ++ ++EK   ++E T+L  E    ++Q
Sbjct: 2254 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2313

Query: 147  DFVAEKLDQQFRERCEELRVELLSI---HQKKVCEERKAQIAFNEELSRQKL-VEEQMFS 202
              +A++  ++ +E  E++  +L       Q+ +  ER+ Q+  + E  R KL V E   +
Sbjct: 2314 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2373

Query: 203  KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQIT---SIKAQRQAT----------- 248
            +   E+   + +++A+E     E +  T L    ++T   +++ QRQ +           
Sbjct: 2374 QARAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2430

Query: 249  -QLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ------- 300
             +L +E+E    E+   Q+K E E   +++++  QET+ + Q  L E+   +Q       
Sbjct: 2431 AELEREKEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2489

Query: 301  ----------------QEYRDEQDLNMKLVQRALQDL---QEEADKKKQKREDMIR-EQK 340
                            Q+ R+EQ    + +++  Q L    EEA +++ + E+ +R +Q+
Sbjct: 2490 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2549

Query: 341  IYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKL- 399
               +   QRR++E+   +E  R+ E+    +L E+     L   +      +V  T+ L 
Sbjct: 2550 ELQQLEQQRRQQEELLAEENQRLREQ---LQLLEEQHRAAL-AHSEEVTASQVAATKTLP 2605

Query: 400  QVQEKLQREAKEQEER----AMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQI 455
              ++ L   A E E       + +K   + L+E      E     QRLAQ          
Sbjct: 2606 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQ---------- 2652

Query: 456  AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNI 501
             +    + A +E+ R   +   +   + L    E LS +  L + +
Sbjct: 2653 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL 2698



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 80/337 (23%), Positives = 143/337 (42%), Gaps = 63/337 (18%)

Query: 149  VAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
            V E+L Q+  ER  ++ VE       ++ E  +A +A       Q  V ++   +L  + 
Sbjct: 1137 VGERLQQRHGER--DVEVERWRERVAQLLERWQAVLA-------QTDVRQRELEQLGRQL 1187

Query: 209  RLAKEKREA-----QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNN 263
            R  +E  +      Q+ARR++E ++   L   A   +++ Q +  Q L EE         
Sbjct: 1188 RYYRESADPLGAWLQDARRRQEQIQAMPL---ADSQAVREQLRQEQALLEE--------- 1235

Query: 264  AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE 323
              I+   E+    ++ AKQ    I    LQ      Q E         K+   +   +QE
Sbjct: 1236 --IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1293

Query: 324  EADKKKQKREDMIREQKIYHKYLAQ--RREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
              D +    E +      Y K++++  RR EE+      +R+ E+ +A++  E+  E+  
Sbjct: 1294 YVDLRTHYSE-LTTLTSQYIKFISETLRRMEEE------ERLAEQQRAEE-RERLAEVEA 1345

Query: 382  EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
              E +RQL +        Q + + +REAKE ++R  E+                   RR+
Sbjct: 1346 ALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEE-----------------VVRRE 1383

Query: 442  RL---AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
                 AQ+ ++ +Q ++   +QS EAE + K R+ EA
Sbjct: 1384 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1420


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 120/517 (23%), Positives = 237/517 (45%), Gaps = 51/517 (9%)

Query: 2    YSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDR 61
            ++++   ++R ++     V  +R +  +    +   ER R   ++       +K++E  R
Sbjct: 1571 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW-QLKANEALR 1629

Query: 62   LKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLA----LEENEYFTEMQ 117
            L+ + ++    K L      + K+  +        RR K  E       L E E   + Q
Sbjct: 1630 LRLQAEEVAQQKSLAQAEAEKQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQ 1685

Query: 118  LKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRERC------EELRVELLS 170
            L + T +++    +E  +L  E  + E+Q   + E+L +  RE        +EL  EL  
Sbjct: 1686 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1745

Query: 171  IH-QKKVCEERKAQIA----FNEELSRQKL-VEEQMFSKLWEEDRLAKEKREAQEARRQK 224
            +  + +V    KA+         E S+Q+L  E   F +L EE   A+ +  A+EA+RQ+
Sbjct: 1746 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE--AARLRALAEEAKRQR 1803

Query: 225  ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQET 284
            +L E           + + + +A ++L E+ A + E+   ++K E E  + +K+   +  
Sbjct: 1804 QLAEED---------AARQRAEAERVLAEKLAAIGEAT--RLKTEAEIALKEKEAENERL 1852

Query: 285  RTILQKALQERIEHIQQEYRDEQDLNMKLVQ-RALQDLQEEADKKKQKREDMIREQK-IY 342
            R + +    +R    +Q  + + D+  +L Q R   D   E +++K   ED +R+++ + 
Sbjct: 1853 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVE 1910

Query: 343  HKYLAQRREEEKAQEKEFDRILEEDKAKKLAE----KDKELRLEKEARRQLVDEVMCTRK 398
             + LA +   EKA   + +  LE  + +  AE      ++  LE   +RQL  E    R+
Sbjct: 1911 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE-RRR 1969

Query: 399  LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM-QIAY 457
             + +E++Q+    +EE A ++K   E ++ L  + +E    R+R  QE  +QLQ+ Q A 
Sbjct: 1970 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2029

Query: 458  QQQSQEAEK------EEKRREFEAGVAANKMCLDKVQ 488
            Q++ Q  EK      ++K +E +  +   +  LD+++
Sbjct: 2030 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2066



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 121/487 (24%), Positives = 226/487 (46%), Gaps = 49/487 (10%)

Query: 34   EHHLERIRRSHQKHNAILASIKSSERDRLKAEWD----QHNDCKILDSLVRARIKDAVQG 89
            E  L + R+  ++  A+ AS + +   + + E +    + N    L S  +A ++ A Q 
Sbjct: 1900 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1959

Query: 90   FIINIEERRNK-----LRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE 144
             +   EERR +     +++ LA EE E   + +   E +E  K ++ E+ + L+E+ E+E
Sbjct: 1960 QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKV-EEARRLRERAEQE 2017

Query: 145  --RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS 202
              RQ  +A++  Q+ R + EE +    ++ QK+  +E +  +   + +  Q   E +   
Sbjct: 2018 SARQLQLAQEAAQK-RLQAEE-KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAAR 2073

Query: 203  KLWEEDRLAK--EKREAQEARRQKELMENTRLGLNAQITS-IKAQRQATQLLKEEE---A 256
            +  EE   A+   +REA ++RRQ E  E  +     Q  +  +AQ  A +L KE E   A
Sbjct: 2074 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2133

Query: 257  RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
            R  ++  A ++ +   D   ++  K   +T+ QKA  E+     +   +E D    L+  
Sbjct: 2134 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2193

Query: 317  ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
             LQ L+ EA +  ++R  +  E       L   R + +   K   RI  E++A  L +KD
Sbjct: 2194 ELQRLKAEATEAARQRSQVEEE-------LFSVRVQMEELSKLKARIEAENRALILRDKD 2246

Query: 377  KELRL---EKEARRQLVDEVM-CTRKLQVQEKLQREAKEQ--EERAMEQKHINESLK--- 427
               R    E E  +Q+ +E    +   Q   +L++ A+E   ++RA+ +K + E ++   
Sbjct: 2247 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2306

Query: 428  ---------ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQS-QEAEKEEKRREFEAGV 477
                     EL  ++KE    + R  QE ++Q+  Q+A + Q  Q   + E++R+ E   
Sbjct: 2307 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2366

Query: 478  AANKMCL 484
             A ++ L
Sbjct: 2367 EAERLKL 2373



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 110/422 (26%), Positives = 192/422 (45%), Gaps = 53/422 (12%)

Query: 96   ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
            E   +L E    EE E   E+    E   EK+ ++ E     K + E+E     A++L Q
Sbjct: 1331 EEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQAKAQAERE-----AKELQQ 1381

Query: 156  QFRE---RCEELRVELLSIHQKKVCEERKAQIAFNEEL-----SRQKLVEEQMFSKLWEE 207
            + +E   R EE  V+  +  QK+  +E   Q+  + E      +RQ    E+   ++ EE
Sbjct: 1382 RMQEEVVRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1439

Query: 208  DRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK 267
             R+ + + EA E  RQ+   E     L A+    +AQ++  Q   E   R V+ + +Q K
Sbjct: 1440 IRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ-DESQRK 1496

Query: 268  HENEQDMLKKQKAKQETRTILQKALQE------RIEHIQQEYRDEQDLNMKLVQRALQDL 321
             + E ++  + KA+ E     Q+ALQ       + E  ++  R  +    + VQ AL+  
Sbjct: 1497 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1556

Query: 322  QEEADKKKQ--------KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
            Q  A+ + Q        K   + R  +  H  +AQ REE    E+   +  E ++A++ A
Sbjct: 1557 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRAQQQAEAERAREEA 1613

Query: 374  EKDKE---LRLEKEARRQLVDEVMCTRKLQVQ-------EKLQREAKEQ---EERAMEQK 420
            E++ E   L+  +  R +L  E +  +K   Q       E+ +REA+ +   EE+A+ Q+
Sbjct: 1614 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1673

Query: 421  HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAY-QQQSQEAEKEEKRREFEAGVAA 479
             + E   E   +  E  A+++  A++   +L+ +    +QQ Q  E+E  R + EA  A 
Sbjct: 1674 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1733

Query: 480  NK 481
             K
Sbjct: 1734 QK 1735



 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 115/542 (21%), Positives = 227/542 (41%), Gaps = 98/542 (18%)

Query: 33   AEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFII 92
            A+   ER+RR  Q  +      +     R+KAE +   +        + R   A++   +
Sbjct: 1478 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--------KQRALQALEELRL 1529

Query: 93   NIEERRNKLRELLALEENEYFTEMQLKKET--------IEEKKDRMREKTKLLKEKNEKE 144
              EE   +LR+     E E   ++Q+  ET        ++ K+    EKT  L+   ++E
Sbjct: 1530 QAEEAERRLRQA----EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1585

Query: 145  -------RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVE 197
                   R++       Q   ER  E     L   Q K  E  + ++   E   ++ L +
Sbjct: 1586 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1645

Query: 198  EQMFSKLWEEDRLAKEKREA------------QEARRQKELMENT---RLGLNAQITSIK 242
             +   +  E +R A+ + +A            QE  +Q++L E T   RL    ++  ++
Sbjct: 1646 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1705

Query: 243  AQ----RQATQLLKEEEARL-------------VESNNAQIKHENEQDMLKKQKAKQETR 285
            A+     Q  QLL+EE ARL             +E+  A+++ E E  +  K +A++E+R
Sbjct: 1706 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1765

Query: 286  TILQKALQE----------------RIEHIQQEYRDEQDLNMKLVQRALQDLQE------ 323
            +  +K+ Q                 R+  + +E + ++ L  +   R   + +       
Sbjct: 1766 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1825

Query: 324  ----EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA---KKLAEKD 376
                EA + K + E  ++E++  ++ L +  E+E  Q +  +    + KA   ++LA+  
Sbjct: 1826 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1885

Query: 377  KELRLEKEARRQLVDEVMCTRKLQVQEKL-------QREAKEQEERAMEQKHINESLKEL 429
            K    E E ++ LV++ +  R+ QV+E++       ++ A  + E  +E   I  + ++ 
Sbjct: 1886 KASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1944

Query: 430  --NCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKV 487
              + E+ E  A RQR      ++ + +   + Q   A +EE  R+ +A +   +    KV
Sbjct: 1945 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2004

Query: 488  QE 489
            +E
Sbjct: 2005 EE 2006



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 88/386 (22%), Positives = 183/386 (47%), Gaps = 21/386 (5%)

Query: 92   INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKN-EKERQDFVA 150
            I ++E+  +   L  L E+E F   +L+++  + K D      +L K  + E ERQ  + 
Sbjct: 1840 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1899

Query: 151  EKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSR-QKLVEEQMFSKLWEEDR 209
            E   +Q R+  EE+ + L +  +K    + + ++    EL R +   E+ + SK   E  
Sbjct: 1900 EDTLRQRRQVEEEI-LALKASFEKAAAGKAELEL----ELGRIRSNAEDTLRSKEQAELE 1954

Query: 210  LAKEKR-EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
             A++++  A+E RR++E  E  +  L A+  + + ++ A + ++  +A++ E+   +++ 
Sbjct: 1955 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR--RLRE 2012

Query: 269  ENEQDMLKKQKAKQETRTILQKALQ-ERIEHIQQEYRDEQDLNMKLVQR--ALQDLQEEA 325
              EQ+  ++ +  QE     QK LQ E   H     + EQ+L   L Q    L  L+ EA
Sbjct: 2013 RAEQESARQLQLAQEAA---QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2069

Query: 326  DKKKQKREDMIREQKIYHKYLAQRR----EEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
            +  ++  E+    +    +  AQ R    E E+ ++   ++     +A+  AEK ++   
Sbjct: 2070 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2129

Query: 382  EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
            ++ ARR   ++    +K     ++++  K  E+   ++  + + L  L  + +E   ++ 
Sbjct: 2130 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2189

Query: 442  RLAQE-YRKQLQMQIAYQQQSQEAEK 466
             L +E  R + +   A +Q+SQ  E+
Sbjct: 2190 LLDEELQRLKAEATEAARQRSQVEEE 2215



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 65/280 (23%), Positives = 143/280 (51%), Gaps = 29/280 (10%)

Query: 194  KLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKE 253
            K + E +  ++ EE+RLA+++R A+E  R  E+             +++ QRQ  +   +
Sbjct: 1321 KFISETL-RRMEEEERLAEQQR-AEERERLAEVE-----------AALEKQRQLAEAHAQ 1367

Query: 254  EEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKL 313
             +A+  E    +++   +++++++++A  + +   ++++QE ++ ++Q    E ++  K 
Sbjct: 1368 AKAQ-AEREAKELQQRMQEEVVRREEAAVDAQQ-QKRSIQEELQQLRQS--SEAEIQAKA 1423

Query: 314  VQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
             Q       E A++ + + E+ IR  ++  +   ++R   + + +      EE +A+K  
Sbjct: 1424 RQA------EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1477

Query: 374  EKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEE 433
             +++  RL    RRQ+ DE    RK Q + +L    K + E A E++   ++L+EL  + 
Sbjct: 1478 AQEEAERL----RRQVQDESQ--RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1531

Query: 434  KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
            +E   R ++   E  +Q+Q+ +   Q+S EAE + KR  F
Sbjct: 1532 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1571



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 112/526 (21%), Positives = 218/526 (41%), Gaps = 92/526 (17%)

Query: 41   RRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNK 100
            +RS  +       ++  E  +LKA  +  N   IL      R KD  Q F+    E+  +
Sbjct: 2208 QRSQVEEELFSVRVQMEELSKLKARIEAENRALIL------RDKDNTQRFLQEEAEKMKQ 2261

Query: 101  LRE--------------LLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQ 146
            + E              L  L E +   +  L ++ ++EK   ++E T+L  E    ++Q
Sbjct: 2262 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2321

Query: 147  DFVAEKLDQQFRERCEELRVELLSI---HQKKVCEERKAQIAFNEELSRQKL-VEEQMFS 202
              +A++  ++ +E  E++  +L       Q+ +  ER+ Q+  + E  R KL V E   +
Sbjct: 2322 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2381

Query: 203  KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQIT---SIKAQRQAT----------- 248
            +   E+   + +++A+E     E +  T L    ++T   +++ QRQ +           
Sbjct: 2382 QARAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2438

Query: 249  -QLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ------- 300
             +L +E+E    E+   Q+K E E   +++++  QET+ + Q  L E+   +Q       
Sbjct: 2439 AELEREKEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2497

Query: 301  ----------------QEYRDEQDLNMKLVQRALQDL---QEEADKKKQKREDMIR-EQK 340
                            Q+ R+EQ    + +++  Q L    EEA +++ + E+ +R +Q+
Sbjct: 2498 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2557

Query: 341  IYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKL- 399
               +   QRR++E+   +E  R+ E+    +L E+     L   +      +V  T+ L 
Sbjct: 2558 ELQQLEQQRRQQEELLAEENQRLREQ---LQLLEEQHRAAL-AHSEEVTASQVAATKTLP 2613

Query: 400  QVQEKLQREAKEQEER----AMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQI 455
              ++ L   A E E       + +K   + L+E      E     QRLAQ          
Sbjct: 2614 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQ---------- 2660

Query: 456  AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNI 501
             +    + A +E+ R   +   +   + L    E LS +  L + +
Sbjct: 2661 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL 2706



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 80/337 (23%), Positives = 143/337 (42%), Gaps = 63/337 (18%)

Query: 149  VAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
            V E+L Q+  ER  ++ VE       ++ E  +A +A       Q  V ++   +L  + 
Sbjct: 1145 VGERLQQRHGER--DVEVERWRERVAQLLERWQAVLA-------QTDVRQRELEQLGRQL 1195

Query: 209  RLAKEKREA-----QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNN 263
            R  +E  +      Q+ARR++E ++   L   A   +++ Q +  Q L EE         
Sbjct: 1196 RYYRESADPLGAWLQDARRRQEQIQAMPL---ADSQAVREQLRQEQALLEE--------- 1243

Query: 264  AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE 323
              I+   E+    ++ AKQ    I    LQ      Q E         K+   +   +QE
Sbjct: 1244 --IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1301

Query: 324  EADKKKQKREDMIREQKIYHKYLAQ--RREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
              D +    E +      Y K++++  RR EE+      +R+ E+ +A++  E+  E+  
Sbjct: 1302 YVDLRTHYSE-LTTLTSQYIKFISETLRRMEEE------ERLAEQQRAEE-RERLAEVEA 1353

Query: 382  EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
              E +RQL +        Q + + +REAKE ++R  E+                   RR+
Sbjct: 1354 ALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEE-----------------VVRRE 1391

Query: 442  RL---AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
                 AQ+ ++ +Q ++   +QS EAE + K R+ EA
Sbjct: 1392 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1428


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 120/517 (23%), Positives = 237/517 (45%), Gaps = 51/517 (9%)

Query: 2    YSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDR 61
            ++++   ++R ++     V  +R +  +    +   ER R   ++       +K++E  R
Sbjct: 1612 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW-QLKANEALR 1670

Query: 62   LKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLA----LEENEYFTEMQ 117
            L+ + ++    K L      + K+  +        RR K  E       L E E   + Q
Sbjct: 1671 LRLQAEEVAQQKSLAQAEAEKQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQ 1726

Query: 118  LKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRERC------EELRVELLS 170
            L + T +++    +E  +L  E  + E+Q   + E+L +  RE        +EL  EL  
Sbjct: 1727 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1786

Query: 171  IH-QKKVCEERKAQIA----FNEELSRQKL-VEEQMFSKLWEEDRLAKEKREAQEARRQK 224
            +  + +V    KA+         E S+Q+L  E   F +L EE   A+ +  A+EA+RQ+
Sbjct: 1787 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE--AARLRALAEEAKRQR 1844

Query: 225  ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQET 284
            +L E           + + + +A ++L E+ A + E+   ++K E E  + +K+   +  
Sbjct: 1845 QLAEED---------AARQRAEAERVLAEKLAAIGEAT--RLKTEAEIALKEKEAENERL 1893

Query: 285  RTILQKALQERIEHIQQEYRDEQDLNMKLVQ-RALQDLQEEADKKKQKREDMIREQK-IY 342
            R + +    +R    +Q  + + D+  +L Q R   D   E +++K   ED +R+++ + 
Sbjct: 1894 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVE 1951

Query: 343  HKYLAQRREEEKAQEKEFDRILEEDKAKKLAE----KDKELRLEKEARRQLVDEVMCTRK 398
             + LA +   EKA   + +  LE  + +  AE      ++  LE   +RQL  E    R+
Sbjct: 1952 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE-RRR 2010

Query: 399  LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM-QIAY 457
             + +E++Q+    +EE A ++K   E ++ L  + +E    R+R  QE  +QLQ+ Q A 
Sbjct: 2011 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2070

Query: 458  QQQSQEAEK------EEKRREFEAGVAANKMCLDKVQ 488
            Q++ Q  EK      ++K +E +  +   +  LD+++
Sbjct: 2071 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2107



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 121/487 (24%), Positives = 226/487 (46%), Gaps = 49/487 (10%)

Query: 34   EHHLERIRRSHQKHNAILASIKSSERDRLKAEWD----QHNDCKILDSLVRARIKDAVQG 89
            E  L + R+  ++  A+ AS + +   + + E +    + N    L S  +A ++ A Q 
Sbjct: 1941 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2000

Query: 90   FIINIEERRNK-----LRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE 144
             +   EERR +     +++ LA EE E   + +   E +E  K ++ E+ + L+E+ E+E
Sbjct: 2001 QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKV-EEARRLRERAEQE 2058

Query: 145  --RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS 202
              RQ  +A++  Q+ R + EE +    ++ QK+  +E +  +   + +  Q   E +   
Sbjct: 2059 SARQLQLAQEAAQK-RLQAEE-KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAAR 2114

Query: 203  KLWEEDRLAK--EKREAQEARRQKELMENTRLGLNAQITS-IKAQRQATQLLKEEE---A 256
            +  EE   A+   +REA ++RRQ E  E  +     Q  +  +AQ  A +L KE E   A
Sbjct: 2115 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2174

Query: 257  RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
            R  ++  A ++ +   D   ++  K   +T+ QKA  E+     +   +E D    L+  
Sbjct: 2175 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2234

Query: 317  ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
             LQ L+ EA +  ++R  +  E       L   R + +   K   RI  E++A  L +KD
Sbjct: 2235 ELQRLKAEATEAARQRSQVEEE-------LFSVRVQMEELSKLKARIEAENRALILRDKD 2287

Query: 377  KELRL---EKEARRQLVDEVM-CTRKLQVQEKLQREAKEQ--EERAMEQKHINESLK--- 427
               R    E E  +Q+ +E    +   Q   +L++ A+E   ++RA+ +K + E ++   
Sbjct: 2288 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2347

Query: 428  ---------ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQS-QEAEKEEKRREFEAGV 477
                     EL  ++KE    + R  QE ++Q+  Q+A + Q  Q   + E++R+ E   
Sbjct: 2348 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2407

Query: 478  AANKMCL 484
             A ++ L
Sbjct: 2408 EAERLKL 2414



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 110/422 (26%), Positives = 192/422 (45%), Gaps = 53/422 (12%)

Query: 96   ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
            E   +L E    EE E   E+    E   EK+ ++ E     K + E+E     A++L Q
Sbjct: 1372 EEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQAKAQAERE-----AKELQQ 1422

Query: 156  QFRE---RCEELRVELLSIHQKKVCEERKAQIAFNEEL-----SRQKLVEEQMFSKLWEE 207
            + +E   R EE  V+  +  QK+  +E   Q+  + E      +RQ    E+   ++ EE
Sbjct: 1423 RMQEEVVRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1480

Query: 208  DRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK 267
             R+ + + EA E  RQ+   E     L A+    +AQ++  Q   E   R V+ + +Q K
Sbjct: 1481 IRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ-DESQRK 1537

Query: 268  HENEQDMLKKQKAKQETRTILQKALQE------RIEHIQQEYRDEQDLNMKLVQRALQDL 321
             + E ++  + KA+ E     Q+ALQ       + E  ++  R  +    + VQ AL+  
Sbjct: 1538 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1597

Query: 322  QEEADKKKQ--------KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
            Q  A+ + Q        K   + R  +  H  +AQ REE    E+   +  E ++A++ A
Sbjct: 1598 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRAQQQAEAERAREEA 1654

Query: 374  EKDKE---LRLEKEARRQLVDEVMCTRKLQVQ-------EKLQREAKEQ---EERAMEQK 420
            E++ E   L+  +  R +L  E +  +K   Q       E+ +REA+ +   EE+A+ Q+
Sbjct: 1655 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1714

Query: 421  HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAY-QQQSQEAEKEEKRREFEAGVAA 479
             + E   E   +  E  A+++  A++   +L+ +    +QQ Q  E+E  R + EA  A 
Sbjct: 1715 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1774

Query: 480  NK 481
             K
Sbjct: 1775 QK 1776



 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 115/542 (21%), Positives = 227/542 (41%), Gaps = 98/542 (18%)

Query: 33   AEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFII 92
            A+   ER+RR  Q  +      +     R+KAE +   +        + R   A++   +
Sbjct: 1519 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--------KQRALQALEELRL 1570

Query: 93   NIEERRNKLRELLALEENEYFTEMQLKKET--------IEEKKDRMREKTKLLKEKNEKE 144
              EE   +LR+     E E   ++Q+  ET        ++ K+    EKT  L+   ++E
Sbjct: 1571 QAEEAERRLRQA----EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1626

Query: 145  -------RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVE 197
                   R++       Q   ER  E     L   Q K  E  + ++   E   ++ L +
Sbjct: 1627 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1686

Query: 198  EQMFSKLWEEDRLAKEKREA------------QEARRQKELMENT---RLGLNAQITSIK 242
             +   +  E +R A+ + +A            QE  +Q++L E T   RL    ++  ++
Sbjct: 1687 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1746

Query: 243  AQ----RQATQLLKEEEARL-------------VESNNAQIKHENEQDMLKKQKAKQETR 285
            A+     Q  QLL+EE ARL             +E+  A+++ E E  +  K +A++E+R
Sbjct: 1747 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806

Query: 286  TILQKALQE----------------RIEHIQQEYRDEQDLNMKLVQRALQDLQE------ 323
            +  +K+ Q                 R+  + +E + ++ L  +   R   + +       
Sbjct: 1807 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1866

Query: 324  ----EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA---KKLAEKD 376
                EA + K + E  ++E++  ++ L +  E+E  Q +  +    + KA   ++LA+  
Sbjct: 1867 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1926

Query: 377  KELRLEKEARRQLVDEVMCTRKLQVQEKL-------QREAKEQEERAMEQKHINESLKEL 429
            K    E E ++ LV++ +  R+ QV+E++       ++ A  + E  +E   I  + ++ 
Sbjct: 1927 KASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1985

Query: 430  --NCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKV 487
              + E+ E  A RQR      ++ + +   + Q   A +EE  R+ +A +   +    KV
Sbjct: 1986 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2045

Query: 488  QE 489
            +E
Sbjct: 2046 EE 2047



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 88/386 (22%), Positives = 183/386 (47%), Gaps = 21/386 (5%)

Query: 92   INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKN-EKERQDFVA 150
            I ++E+  +   L  L E+E F   +L+++  + K D      +L K  + E ERQ  + 
Sbjct: 1881 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1940

Query: 151  EKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSR-QKLVEEQMFSKLWEEDR 209
            E   +Q R+  EE+ + L +  +K    + + ++    EL R +   E+ + SK   E  
Sbjct: 1941 EDTLRQRRQVEEEI-LALKASFEKAAAGKAELEL----ELGRIRSNAEDTLRSKEQAELE 1995

Query: 210  LAKEKR-EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
             A++++  A+E RR++E  E  +  L A+  + + ++ A + ++  +A++ E+   +++ 
Sbjct: 1996 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR--RLRE 2053

Query: 269  ENEQDMLKKQKAKQETRTILQKALQ-ERIEHIQQEYRDEQDLNMKLVQR--ALQDLQEEA 325
              EQ+  ++ +  QE     QK LQ E   H     + EQ+L   L Q    L  L+ EA
Sbjct: 2054 RAEQESARQLQLAQEAA---QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2110

Query: 326  DKKKQKREDMIREQKIYHKYLAQRR----EEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
            +  ++  E+    +    +  AQ R    E E+ ++   ++     +A+  AEK ++   
Sbjct: 2111 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2170

Query: 382  EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
            ++ ARR   ++    +K     ++++  K  E+   ++  + + L  L  + +E   ++ 
Sbjct: 2171 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2230

Query: 442  RLAQE-YRKQLQMQIAYQQQSQEAEK 466
             L +E  R + +   A +Q+SQ  E+
Sbjct: 2231 LLDEELQRLKAEATEAARQRSQVEEE 2256



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 65/280 (23%), Positives = 143/280 (51%), Gaps = 29/280 (10%)

Query: 194  KLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKE 253
            K + E +  ++ EE+RLA+++R A+E  R  E+             +++ QRQ  +   +
Sbjct: 1362 KFISETL-RRMEEEERLAEQQR-AEERERLAEVE-----------AALEKQRQLAEAHAQ 1408

Query: 254  EEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKL 313
             +A+  E    +++   +++++++++A  + +   ++++QE ++ ++Q    E ++  K 
Sbjct: 1409 AKAQ-AEREAKELQQRMQEEVVRREEAAVDAQQ-QKRSIQEELQQLRQS--SEAEIQAKA 1464

Query: 314  VQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
             Q       E A++ + + E+ IR  ++  +   ++R   + + +      EE +A+K  
Sbjct: 1465 RQA------EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1518

Query: 374  EKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEE 433
             +++  RL    RRQ+ DE    RK Q + +L    K + E A E++   ++L+EL  + 
Sbjct: 1519 AQEEAERL----RRQVQDESQ--RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1572

Query: 434  KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
            +E   R ++   E  +Q+Q+ +   Q+S EAE + KR  F
Sbjct: 1573 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1612



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 112/526 (21%), Positives = 218/526 (41%), Gaps = 92/526 (17%)

Query: 41   RRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNK 100
            +RS  +       ++  E  +LKA  +  N   IL      R KD  Q F+    E+  +
Sbjct: 2249 QRSQVEEELFSVRVQMEELSKLKARIEAENRALIL------RDKDNTQRFLQEEAEKMKQ 2302

Query: 101  LRE--------------LLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQ 146
            + E              L  L E +   +  L ++ ++EK   ++E T+L  E    ++Q
Sbjct: 2303 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2362

Query: 147  DFVAEKLDQQFRERCEELRVELLSI---HQKKVCEERKAQIAFNEELSRQKL-VEEQMFS 202
              +A++  ++ +E  E++  +L       Q+ +  ER+ Q+  + E  R KL V E   +
Sbjct: 2363 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2422

Query: 203  KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQIT---SIKAQRQAT----------- 248
            +   E+   + +++A+E     E +  T L    ++T   +++ QRQ +           
Sbjct: 2423 QARAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2479

Query: 249  -QLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ------- 300
             +L +E+E    E+   Q+K E E   +++++  QET+ + Q  L E+   +Q       
Sbjct: 2480 AELEREKEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2538

Query: 301  ----------------QEYRDEQDLNMKLVQRALQDL---QEEADKKKQKREDMIR-EQK 340
                            Q+ R+EQ    + +++  Q L    EEA +++ + E+ +R +Q+
Sbjct: 2539 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2598

Query: 341  IYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKL- 399
               +   QRR++E+   +E  R+ E+    +L E+     L   +      +V  T+ L 
Sbjct: 2599 ELQQLEQQRRQQEELLAEENQRLREQ---LQLLEEQHRAAL-AHSEEVTASQVAATKTLP 2654

Query: 400  QVQEKLQREAKEQEER----AMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQI 455
              ++ L   A E E       + +K   + L+E      E     QRLAQ          
Sbjct: 2655 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQ---------- 2701

Query: 456  AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNI 501
             +    + A +E+ R   +   +   + L    E LS +  L + +
Sbjct: 2702 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL 2747



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 80/337 (23%), Positives = 143/337 (42%), Gaps = 63/337 (18%)

Query: 149  VAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
            V E+L Q+  ER  ++ VE       ++ E  +A +A       Q  V ++   +L  + 
Sbjct: 1186 VGERLQQRHGER--DVEVERWRERVAQLLERWQAVLA-------QTDVRQRELEQLGRQL 1236

Query: 209  RLAKEKREA-----QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNN 263
            R  +E  +      Q+ARR++E ++   L   A   +++ Q +  Q L EE         
Sbjct: 1237 RYYRESADPLGAWLQDARRRQEQIQAMPL---ADSQAVREQLRQEQALLEE--------- 1284

Query: 264  AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE 323
              I+   E+    ++ AKQ    I    LQ      Q E         K+   +   +QE
Sbjct: 1285 --IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1342

Query: 324  EADKKKQKREDMIREQKIYHKYLAQ--RREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
              D +    E +      Y K++++  RR EE+      +R+ E+ +A++  E+  E+  
Sbjct: 1343 YVDLRTHYSE-LTTLTSQYIKFISETLRRMEEE------ERLAEQQRAEE-RERLAEVEA 1394

Query: 382  EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
              E +RQL +        Q + + +REAKE ++R  E+                   RR+
Sbjct: 1395 ALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEE-----------------VVRRE 1432

Query: 442  RL---AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
                 AQ+ ++ +Q ++   +QS EAE + K R+ EA
Sbjct: 1433 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1469


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 72/299 (24%), Positives = 150/299 (50%), Gaps = 46/299 (15%)

Query: 212 KEKREAQEARRQK------ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQ 265
           + K EA++ RRQK        +E  +L    ++  +   R+  + +KEE+ + +E   AQ
Sbjct: 546 RRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQ 605

Query: 266 IKHENE---QDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLN-MKLVQRALQDL 321
           I  + E   ++ L ++KAK+       KA  +++E ++   + E++   ++ +Q+  ++ 
Sbjct: 606 IDEKTEKAKEERLAEEKAKK-------KAAAKKMEEVEARRKQEEEARRLRWLQQEEEER 658

Query: 322 QEEADKKKQKREDMIREQKIYH-KYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELR 380
           + +   +K+K E+  R +K    K LA++RE+E+ +++  ++   E + ++   +++E +
Sbjct: 659 RHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQ 718

Query: 381 LEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARR 440
           L ++ RR+  + +   R+LQ +EK  R  KEQ +R +E+K   E               +
Sbjct: 719 LAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKE--------------EQ 764

Query: 441 QRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQ 499
           QRLA+   +QLQ            E+E+K +E      A  + +D      +++Q+ PQ
Sbjct: 765 QRLAE---RQLQ-----------EEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQ 809



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 82/320 (25%), Positives = 159/320 (49%), Gaps = 74/320 (23%)

Query: 94  IEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKL 153
           +E+ R +L  L   EE E     QL+++ +EE K R  E+ KL +E+  ++         
Sbjct: 535 VEKERQRLENLRRKEEAE-----QLRRQKVEEDKRRRLEEVKLKREERLRKVL------- 582

Query: 154 DQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKE 213
             Q RER E+++            EE+K QI             EQ F+++ E+   AKE
Sbjct: 583 --QARERVEQMK------------EEKKKQI-------------EQKFAQIDEKTEKAKE 615

Query: 214 KREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQD 273
           +R A+E  ++K   +        ++  ++A+R+     +EEEAR +     + +    Q+
Sbjct: 616 ERLAEEKAKKKAAAK--------KMEEVEARRK-----QEEEARRLRWLQQEEEERRHQE 662

Query: 274 MLKKQKAKQETRTILQKALQER--IEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQK 331
           +L+K+K +++ R  L+KA + +   E  +QE R+             Q+ +E+  +++++
Sbjct: 663 LLQKKKEEEQER--LRKAAEAKRLAEQREQERRE-------------QERREQERREQER 707

Query: 332 REDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVD 391
           RE   REQ+       +RRE+E+ Q +    + E +KA +L ++  +  LE++ +++   
Sbjct: 708 REQERREQERQLAEQERRREQERLQAER--ELQEREKALRLQKEQLQRELEEKKKKE--- 762

Query: 392 EVMCTRKLQVQEKLQREAKE 411
           E     + Q+QE+ +++AKE
Sbjct: 763 EQQRLAERQLQEEQEKKAKE 782



 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 70/283 (24%), Positives = 139/283 (49%), Gaps = 60/283 (21%)

Query: 226 LMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETR 285
           +  NT L ++ + + ++ +RQ  + L+ +E    E    Q   E+++  L++ K K+E R
Sbjct: 520 IKRNTPLRMDPKCSFVEKERQRLENLRRKEE--AEQLRRQKVEEDKRRRLEEVKLKREER 577

Query: 286 TILQKALQ--ERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYH 343
             L+K LQ  ER+E +++E +       K +++    + E+ +K K++R   + E+K   
Sbjct: 578 --LRKVLQARERVEQMKEEKK-------KQIEQKFAQIDEKTEKAKEER---LAEEKAKK 625

Query: 344 KYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQE 403
           K  A++ EE +A+ K+      E++A++L    + L+ E+E RR              QE
Sbjct: 626 KAAAKKMEEVEARRKQ------EEEARRL----RWLQQEEEERRH-------------QE 662

Query: 404 KLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQE 463
            LQ++ +E++ER  +                   A  +RLA++  ++ + Q   +Q+ +E
Sbjct: 663 LLQKKKEEEQERLRKA------------------AEAKRLAEQREQERREQERREQERRE 704

Query: 464 AEK-EEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNIHPMR 505
            E+ E++RRE E  +A  +    + QE L   + L +    +R
Sbjct: 705 QERREQERREQERQLAEQER--RREQERLQAERELQEREKALR 745



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 49/195 (25%), Positives = 89/195 (45%), Gaps = 18/195 (9%)

Query: 38  ERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEER 97
           E+ ++  QK   I    + ++ +RL  E  +          V AR K          EE 
Sbjct: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ---------EEE 644

Query: 98  RNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQF 157
             +LR L   EE     E+  KK+  E+++ R   + K L E+ E+ER++    + +++ 
Sbjct: 645 ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 704

Query: 158 RERCEELRVE----LLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKE 213
           +ER E+ R E    L    +++  E  +A+    E     +L +EQ+  +L E     K+
Sbjct: 705 QERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE-----KK 759

Query: 214 KREAQEARRQKELME 228
           K+E Q+   +++L E
Sbjct: 760 KKEEQQRLAERQLQE 774


>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
           sapiens]
          Length = 638

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 119/517 (23%), Positives = 249/517 (48%), Gaps = 67/517 (12%)

Query: 23  VRSKPPKGQGAEHHLERIRRSHQKHNAILASIK----SSERDRLKAEWDQHNDCKILDSL 78
           +R    K +G E  L+  +RS ++    +A ++    S E++++  + +     + ++ +
Sbjct: 95  MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 154

Query: 79  VRARIKDAVQGFIINIEERRNKLREL--------LALEEN-----EYFTEMQLKKETIEE 125
             A   D V+ + ++I +    L+E          +LEEN     +   ++ +K + +E+
Sbjct: 155 SCA--SDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 212

Query: 126 KKD----RMREKTKLLKEKNEKERQDFVAEKLDQQFRERCE--ELRVELLSIHQKKVCEE 179
           +K+    R RE  + L  + +  +Q F+   L+QQ RE+ +  EL+++ L   +K++   
Sbjct: 213 EKEDHVNRNREHNENLNAEMQNLKQKFI---LEQQEREKLQQKELQIDSLLQQEKELSSS 269

Query: 180 RKAQI-AFNEELSRQK-LVEEQMFSKLWEEDRLAKEKREAQEARRQKE-----------L 226
              ++ +F EE+ ++K L EE++   L E D+L +++ +A+   +Q E           L
Sbjct: 270 LHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 329

Query: 227 MENTRLGLNAQIT-SIKAQRQATQLLKEEEARLVESNN---AQIKHENEQDMLKKQKAKQ 282
           +E    G  A++  S  A  QAT LL+E+   +V+S     AQ +        + +  K 
Sbjct: 330 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKL 389

Query: 283 ETRTILQKALQ--ERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQK 340
           E  ++ +KA +  +  E +Q +    +  N + V R L DLQ     K   +E  I+E  
Sbjct: 390 ENSSLQEKAAKAGKNAEDVQHQILATESSNQEYV-RMLLDLQT----KSALKETEIKEIT 444

Query: 341 I-YHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARR-QLVDEVMCTRK 398
           + + + +   + + K QE++F + LE+++ +K  +++    L +E  + +L+ E +  + 
Sbjct: 445 VSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKT 504

Query: 399 LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFAR---RQRLAQEYRKQLQMQI 455
              Q  LQ +A E E++A+  +H   + ++LN + ++++A+    Q L Q+ +  ++++ 
Sbjct: 505 KPFQ--LQLDAFEVEKQALLNEH-GAAQEQLN-KIRDSYAKLLGHQNLKQKIKHVVKLKD 560

Query: 456 AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLS 492
              Q   E  K          +A  K    K+QE L+
Sbjct: 561 ENSQLKSEVSK------LRCQLAKKKQSETKLQEELN 591



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 87/394 (22%), Positives = 172/394 (43%), Gaps = 31/394 (7%)

Query: 100 KLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDF---VAEKLDQQ 156
           +  ELL  + +E   +  L+  ++E  K R + +TK+     ++E  +    V ++  ++
Sbjct: 59  RTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEE 118

Query: 157 FRERCEELRVELLSIHQKKVCEERKAQ--IAFNEELSRQKLVEEQMFSKLWEEDRLAKEK 214
            + +  +L  +L+SI ++K+ E+ + +  + + EE+S      E+    + + +   KEK
Sbjct: 119 SQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEK 178

Query: 215 REAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDM 274
            +  E    K+ +E   + L+ Q+  +  + Q  +  KE+       +N  +  E +   
Sbjct: 179 ND--EILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLK 236

Query: 275 LKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKRE- 333
            K    +QE   + QK LQ     I    + E++L+  L Q+ L   QEE  K+K   E 
Sbjct: 237 QKFILEQQEREKLQQKELQ-----IDSLLQQEKELSSSLHQK-LCSFQEEMVKEKNLFEE 290

Query: 334 ---------DMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKE 384
                    D +++++   + L ++ EEE     E  ++LEE    K AE +K      +
Sbjct: 291 ELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQ 350

Query: 385 ARRQLVDE----VMCTRKLQVQEKLQR--EAKEQEERAMEQKHINESLKELNCEEKENFA 438
           A   L ++    V     +  Q +  +   A E E+  +E   + E  K     +     
Sbjct: 351 ATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQE--KAAKAGKNAEDV 408

Query: 439 RRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRRE 472
           + Q LA E   Q  +++    Q++ A KE + +E
Sbjct: 409 QHQILATESSNQEYVRMLLDLQTKSALKETEIKE 442



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 74/335 (22%), Positives = 144/335 (42%), Gaps = 33/335 (9%)

Query: 160 RCEELRVELLSIHQK-KVCEERKAQIAFNEELSRQKLVE-----EQMFSKLWEEDRLAKE 213
           R ++L  EL  +  +       K  ++ N     ++L+E     E + SK  E       
Sbjct: 18  RIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNL 77

Query: 214 KREAQEARRQKELMENTRLGLNAQITSIKAQRQATQL-LKEEEARLVESNNAQIKHENEQ 272
           +  + E  + +   E    G+ A+   ++ + Q TQ  L+E + ++ +     +  E E 
Sbjct: 78  RILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKE- 136

Query: 273 DMLKKQKAKQETRTILQKALQERIEHIQ--QEYRDEQDLNMKLVQRALQDLQEEADKKKQ 330
               K   K ET  +L     E IE I    +  ++  L++  ++  L++  +E    KQ
Sbjct: 137 ----KIDEKSETEKLL-----EYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQ 187

Query: 331 KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLV 390
             E+ I    I  K +     + +  EKE     +ED   +  E ++ L  E +  +Q  
Sbjct: 188 SLEENI---VILSKQVEDLNVKCQLLEKE-----KEDHVNRNREHNENLNAEMQNLKQKF 239

Query: 391 DEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQ 450
                  + Q +EKLQ++  + +    ++K ++ SL +  C  +E   + + L +E  KQ
Sbjct: 240 -----ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQ 294

Query: 451 LQMQI-AYQQQSQEAEKEEKRREFEAGVAANKMCL 484
              ++   QQ+ ++AE+  K+ E EA   A ++ L
Sbjct: 295 TLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 329


>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
           sapiens]
          Length = 725

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 119/517 (23%), Positives = 249/517 (48%), Gaps = 67/517 (12%)

Query: 23  VRSKPPKGQGAEHHLERIRRSHQKHNAILASIK----SSERDRLKAEWDQHNDCKILDSL 78
           +R    K +G E  L+  +RS ++    +A ++    S E++++  + +     + ++ +
Sbjct: 182 MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 241

Query: 79  VRARIKDAVQGFIINIEERRNKLREL--------LALEEN-----EYFTEMQLKKETIEE 125
             A   D V+ + ++I +    L+E          +LEEN     +   ++ +K + +E+
Sbjct: 242 SCA--SDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 299

Query: 126 KKD----RMREKTKLLKEKNEKERQDFVAEKLDQQFRERCE--ELRVELLSIHQKKVCEE 179
           +K+    R RE  + L  + +  +Q F+   L+QQ RE+ +  EL+++ L   +K++   
Sbjct: 300 EKEDHVNRNREHNENLNAEMQNLKQKFI---LEQQEREKLQQKELQIDSLLQQEKELSSS 356

Query: 180 RKAQI-AFNEELSRQK-LVEEQMFSKLWEEDRLAKEKREAQEARRQKE-----------L 226
              ++ +F EE+ ++K L EE++   L E D+L +++ +A+   +Q E           L
Sbjct: 357 LHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 416

Query: 227 MENTRLGLNAQIT-SIKAQRQATQLLKEEEARLVESNN---AQIKHENEQDMLKKQKAKQ 282
           +E    G  A++  S  A  QAT LL+E+   +V+S     AQ +        + +  K 
Sbjct: 417 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKL 476

Query: 283 ETRTILQKALQ--ERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQK 340
           E  ++ +KA +  +  E +Q +    +  N + V R L DLQ     K   +E  I+E  
Sbjct: 477 ENSSLQEKAAKAGKNAEDVQHQILATESSNQEYV-RMLLDLQT----KSALKETEIKEIT 531

Query: 341 I-YHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARR-QLVDEVMCTRK 398
           + + + +   + + K QE++F + LE+++ +K  +++    L +E  + +L+ E +  + 
Sbjct: 532 VSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKT 591

Query: 399 LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFAR---RQRLAQEYRKQLQMQI 455
              Q  LQ +A E E++A+  +H   + ++LN + ++++A+    Q L Q+ +  ++++ 
Sbjct: 592 KPFQ--LQLDAFEVEKQALLNEH-GAAQEQLN-KIRDSYAKLLGHQNLKQKIKHVVKLKD 647

Query: 456 AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLS 492
              Q   E  K          +A  K    K+QE L+
Sbjct: 648 ENSQLKSEVSK------LRCQLAKKKQSETKLQEELN 678



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 86/408 (21%), Positives = 174/408 (42%), Gaps = 47/408 (11%)

Query: 101 LRELLALEENEYFTEMQLKKETIEEKKDRM----REKTKLLKEKNEKERQDFVAEKLDQQ 156
           L+  ++ ++++ F + +  K+ +   KD        K K  + K E ++ D   + L+++
Sbjct: 32  LKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKE 91

Query: 157 FR----------ERCEELRVELLSIHQK-KVCEERKAQIAFNEELSRQKLVE-----EQM 200
            R           R ++L  EL  +  +       K  ++ N     ++L+E     E +
Sbjct: 92  IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 151

Query: 201 FSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQL-LKEEEARLV 259
            SK  E       +  + E  + +   E    G+ A+   ++ + Q TQ  L+E + ++ 
Sbjct: 152 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 211

Query: 260 ESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ--QEYRDEQDLNMKLVQRA 317
           +     +  E E     K   K ET  +L     E IE I    +  ++  L++  ++  
Sbjct: 212 QLEGKLVSIEKE-----KIDEKSETEKLL-----EYIEEISCASDQVEKYKLDIAQLEEN 261

Query: 318 LQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDK 377
           L++  +E    KQ  E+ I    I  K +     + +  EKE     +ED   +  E ++
Sbjct: 262 LKEKNDEILSLKQSLEENI---VILSKQVEDLNVKCQLLEKE-----KEDHVNRNREHNE 313

Query: 378 ELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENF 437
            L  E +  +Q         + Q +EKLQ++  + +    ++K ++ SL +  C  +E  
Sbjct: 314 NLNAEMQNLKQKF-----ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEM 368

Query: 438 ARRQRLAQEYRKQLQMQI-AYQQQSQEAEKEEKRREFEAGVAANKMCL 484
            + + L +E  KQ   ++   QQ+ ++AE+  K+ E EA   A ++ L
Sbjct: 369 VKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 416



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 110/474 (23%), Positives = 202/474 (42%), Gaps = 68/474 (14%)

Query: 54  IKSSERDRLKAEWDQHNDCKILDSLVRA----------RIKDAVQGFIINIEERRNK-LR 102
           +KSSE  +   + D+  D KIL+  +R           RI+D ++  +  +E R N  LR
Sbjct: 69  VKSSESKKESQKNDK--DLKILEKEIRVLLQERGAQDRRIQD-LETELEKMEARLNAALR 125

Query: 103 ELLALEENEYFTEMQLKK--ETIEEKKDRMREK----------TKLLKEKNEKE------ 144
           E  +L  N    E QL +   T E  K +  E            +L+K +N++E      
Sbjct: 126 EKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGM 185

Query: 145 --RQDFVAEKLD------QQFRERCEELRVELLSIHQKKVCEERKAQ--IAFNEELSRQK 194
             +Q+ +  KL       ++ + +  +L  +L+SI ++K+ E+ + +  + + EE+S   
Sbjct: 186 MAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCAS 245

Query: 195 LVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEE 254
              E+    + + +   KEK +  E    K+ +E   + L+ Q+  +  + Q  +  KE+
Sbjct: 246 DQVEKYKLDIAQLEENLKEKND--EILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKED 303

Query: 255 EARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLV 314
                  +N  +  E +    K    +QE   + QK LQ     I    + E++L+  L 
Sbjct: 304 HVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ-----IDSLLQQEKELSSSLH 358

Query: 315 QRALQDLQEEADKKKQKRE----------DMIREQKIYHKYLAQRREEEKAQEKEFDRIL 364
           Q+ L   QEE  K+K   E          D +++++   + L ++ EEE     E  ++L
Sbjct: 359 QK-LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL 417

Query: 365 EEDKAKKLAEKDKELRLEKEARRQLVDE----VMCTRKLQVQEKLQR--EAKEQEERAME 418
           EE    K AE +K      +A   L ++    V     +  Q +  +   A E E+  +E
Sbjct: 418 EEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLE 477

Query: 419 QKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRRE 472
              + E  K     +     + Q LA E   Q  +++    Q++ A KE + +E
Sbjct: 478 NSSLQE--KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKE 529


>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
           sapiens]
          Length = 709

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 119/517 (23%), Positives = 249/517 (48%), Gaps = 67/517 (12%)

Query: 23  VRSKPPKGQGAEHHLERIRRSHQKHNAILASIK----SSERDRLKAEWDQHNDCKILDSL 78
           +R    K +G E  L+  +RS ++    +A ++    S E++++  + +     + ++ +
Sbjct: 166 MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 225

Query: 79  VRARIKDAVQGFIINIEERRNKLREL--------LALEEN-----EYFTEMQLKKETIEE 125
             A   D V+ + ++I +    L+E          +LEEN     +   ++ +K + +E+
Sbjct: 226 SCA--SDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 283

Query: 126 KKD----RMREKTKLLKEKNEKERQDFVAEKLDQQFRERCE--ELRVELLSIHQKKVCEE 179
           +K+    R RE  + L  + +  +Q F+   L+QQ RE+ +  EL+++ L   +K++   
Sbjct: 284 EKEDHVNRNREHNENLNAEMQNLKQKFI---LEQQEREKLQQKELQIDSLLQQEKELSSS 340

Query: 180 RKAQI-AFNEELSRQK-LVEEQMFSKLWEEDRLAKEKREAQEARRQKE-----------L 226
              ++ +F EE+ ++K L EE++   L E D+L +++ +A+   +Q E           L
Sbjct: 341 LHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 400

Query: 227 MENTRLGLNAQIT-SIKAQRQATQLLKEEEARLVESNN---AQIKHENEQDMLKKQKAKQ 282
           +E    G  A++  S  A  QAT LL+E+   +V+S     AQ +        + +  K 
Sbjct: 401 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKL 460

Query: 283 ETRTILQKALQ--ERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQK 340
           E  ++ +KA +  +  E +Q +    +  N + V R L DLQ     K   +E  I+E  
Sbjct: 461 ENSSLQEKAAKAGKNAEDVQHQILATESSNQEYV-RMLLDLQT----KSALKETEIKEIT 515

Query: 341 I-YHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARR-QLVDEVMCTRK 398
           + + + +   + + K QE++F + LE+++ +K  +++    L +E  + +L+ E +  + 
Sbjct: 516 VSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKT 575

Query: 399 LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFAR---RQRLAQEYRKQLQMQI 455
              Q  LQ +A E E++A+  +H   + ++LN + ++++A+    Q L Q+ +  ++++ 
Sbjct: 576 KPFQ--LQLDAFEVEKQALLNEH-GAAQEQLN-KIRDSYAKLLGHQNLKQKIKHVVKLKD 631

Query: 456 AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLS 492
              Q   E  K          +A  K    K+QE L+
Sbjct: 632 ENSQLKSEVSK------LRCQLAKKKQSETKLQEELN 662



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 82/392 (20%), Positives = 168/392 (42%), Gaps = 31/392 (7%)

Query: 101 LRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRER 160
           L+  ++ ++++ F + +  K+ +   KD     +    + +E + +  + E+  Q  R +
Sbjct: 32  LKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQ 91

Query: 161 CEELRVELLSIHQKKVCEERKAQIAFNEELSRQKL----VEEQMFSKLWEEDRLAKEKRE 216
             E  +E +         E+ +  A N  L +Q +      E + SK  E       +  
Sbjct: 92  DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRIL 151

Query: 217 AQEARRQKELMENTRLGLNAQITSIKAQRQATQL-LKEEEARLVESNNAQIKHENEQDML 275
           + E  + +   E    G+ A+   ++ + Q TQ  L+E + ++ +     +  E E    
Sbjct: 152 SLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKE---- 207

Query: 276 KKQKAKQETRTILQKALQERIEHIQ--QEYRDEQDLNMKLVQRALQDLQEEADKKKQKRE 333
            K   K ET  +L     E IE I    +  ++  L++  ++  L++  +E    KQ  E
Sbjct: 208 -KIDEKSETEKLL-----EYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLE 261

Query: 334 DMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEV 393
           + I    I  K +     + +  EKE     +ED   +  E ++ L  E +  +Q     
Sbjct: 262 ENI---VILSKQVEDLNVKCQLLEKE-----KEDHVNRNREHNENLNAEMQNLKQKF--- 310

Query: 394 MCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM 453
               + Q +EKLQ++  + +    ++K ++ SL +  C  +E   + + L +E  KQ   
Sbjct: 311 --ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLD 368

Query: 454 QI-AYQQQSQEAEKEEKRREFEAGVAANKMCL 484
           ++   QQ+ ++AE+  K+ E EA   A ++ L
Sbjct: 369 ELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 400



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 87/394 (22%), Positives = 172/394 (43%), Gaps = 31/394 (7%)

Query: 100 KLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDF---VAEKLDQQ 156
           +  ELL  + +E   +  L+  ++E  K R + +TK+     ++E  +    V ++  ++
Sbjct: 130 RTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEE 189

Query: 157 FRERCEELRVELLSIHQKKVCEERKAQ--IAFNEELSRQKLVEEQMFSKLWEEDRLAKEK 214
            + +  +L  +L+SI ++K+ E+ + +  + + EE+S      E+    + + +   KEK
Sbjct: 190 SQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEK 249

Query: 215 REAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDM 274
            +  E    K+ +E   + L+ Q+  +  + Q  +  KE+       +N  +  E +   
Sbjct: 250 ND--EILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLK 307

Query: 275 LKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKRE- 333
            K    +QE   + QK LQ     I    + E++L+  L Q+ L   QEE  K+K   E 
Sbjct: 308 QKFILEQQEREKLQQKELQ-----IDSLLQQEKELSSSLHQK-LCSFQEEMVKEKNLFEE 361

Query: 334 ---------DMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKE 384
                    D +++++   + L ++ EEE     E  ++LEE    K AE +K      +
Sbjct: 362 ELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQ 421

Query: 385 ARRQLVDE----VMCTRKLQVQEKLQR--EAKEQEERAMEQKHINESLKELNCEEKENFA 438
           A   L ++    V     +  Q +  +   A E E+  +E   + E  K     +     
Sbjct: 422 ATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQE--KAAKAGKNAEDV 479

Query: 439 RRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRRE 472
           + Q LA E   Q  +++    Q++ A KE + +E
Sbjct: 480 QHQILATESSNQEYVRMLLDLQTKSALKETEIKE 513


>gi|217416394 hyaluronan-mediated motility receptor isoform b [Homo
           sapiens]
          Length = 724

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 119/517 (23%), Positives = 249/517 (48%), Gaps = 67/517 (12%)

Query: 23  VRSKPPKGQGAEHHLERIRRSHQKHNAILASIK----SSERDRLKAEWDQHNDCKILDSL 78
           +R    K +G E  L+  +RS ++    +A ++    S E++++  + +     + ++ +
Sbjct: 181 MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 240

Query: 79  VRARIKDAVQGFIINIEERRNKLREL--------LALEEN-----EYFTEMQLKKETIEE 125
             A   D V+ + ++I +    L+E          +LEEN     +   ++ +K + +E+
Sbjct: 241 SCA--SDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 298

Query: 126 KKD----RMREKTKLLKEKNEKERQDFVAEKLDQQFRERCE--ELRVELLSIHQKKVCEE 179
           +K+    R RE  + L  + +  +Q F+   L+QQ RE+ +  EL+++ L   +K++   
Sbjct: 299 EKEDHVNRNREHNENLNAEMQNLKQKFI---LEQQEREKLQQKELQIDSLLQQEKELSSS 355

Query: 180 RKAQI-AFNEELSRQK-LVEEQMFSKLWEEDRLAKEKREAQEARRQKE-----------L 226
              ++ +F EE+ ++K L EE++   L E D+L +++ +A+   +Q E           L
Sbjct: 356 LHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 415

Query: 227 MENTRLGLNAQIT-SIKAQRQATQLLKEEEARLVESNN---AQIKHENEQDMLKKQKAKQ 282
           +E    G  A++  S  A  QAT LL+E+   +V+S     AQ +        + +  K 
Sbjct: 416 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKL 475

Query: 283 ETRTILQKALQ--ERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQK 340
           E  ++ +KA +  +  E +Q +    +  N + V R L DLQ     K   +E  I+E  
Sbjct: 476 ENSSLQEKAAKAGKNAEDVQHQILATESSNQEYV-RMLLDLQT----KSALKETEIKEIT 530

Query: 341 I-YHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARR-QLVDEVMCTRK 398
           + + + +   + + K QE++F + LE+++ +K  +++    L +E  + +L+ E +  + 
Sbjct: 531 VSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKT 590

Query: 399 LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFAR---RQRLAQEYRKQLQMQI 455
              Q  LQ +A E E++A+  +H   + ++LN + ++++A+    Q L Q+ +  ++++ 
Sbjct: 591 KPFQ--LQLDAFEVEKQALLNEH-GAAQEQLN-KIRDSYAKLLGHQNLKQKIKHVVKLKD 646

Query: 456 AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLS 492
              Q   E  K          +A  K    K+QE L+
Sbjct: 647 ENSQLKSEVSK------LRCQLAKKKQSETKLQEELN 677



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 109/482 (22%), Positives = 200/482 (41%), Gaps = 66/482 (13%)

Query: 46  KHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRA----------RIKDAVQGFIINIE 95
           K   + AS +  +    K       D KIL+  +R           RI+D ++  +  +E
Sbjct: 58  KDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQD-LETELEKME 116

Query: 96  ERRNK-LRELLALEENEYFTEMQLKK--ETIEEKKDRMREK----------TKLLKEKNE 142
            R N  LRE  +L  N    E QL +   T E  K +  E            +L+K +N+
Sbjct: 117 ARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNK 176

Query: 143 KE--------RQDFVAEKLD------QQFRERCEELRVELLSIHQKKVCEERKAQ--IAF 186
           +E        +Q+ +  KL       ++ + +  +L  +L+SI ++K+ E+ + +  + +
Sbjct: 177 RETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEY 236

Query: 187 NEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQ 246
            EE+S      E+    + + +   KEK +  E    K+ +E   + L+ Q+  +  + Q
Sbjct: 237 IEEISCASDQVEKYKLDIAQLEENLKEKND--EILSLKQSLEENIVILSKQVEDLNVKCQ 294

Query: 247 ATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDE 306
             +  KE+       +N  +  E +    K    +QE   + QK LQ     I    + E
Sbjct: 295 LLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ-----IDSLLQQE 349

Query: 307 QDLNMKLVQRALQDLQEEADKKKQKRE----------DMIREQKIYHKYLAQRREEEKAQ 356
           ++L+  L Q+ L   QEE  K+K   E          D +++++   + L ++ EEE   
Sbjct: 350 KELSSSLHQK-LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKS 408

Query: 357 EKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDE----VMCTRKLQVQEKLQR--EAK 410
             E  ++LEE    K AE +K      +A   L ++    V     +  Q +  +   A 
Sbjct: 409 RAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTAS 468

Query: 411 EQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKR 470
           E E+  +E   + E  K     +     + Q LA E   Q  +++    Q++ A KE + 
Sbjct: 469 EIEDLKLENSSLQE--KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEI 526

Query: 471 RE 472
           +E
Sbjct: 527 KE 528



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 86/398 (21%), Positives = 173/398 (43%), Gaps = 36/398 (9%)

Query: 96  ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKT-KLLKEKNEKERQDFVAEKLD 154
           +++ + ++ L ++++        K ++ E K+ +  +K  K+L    EKE +  + E+  
Sbjct: 45  KQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKIL----EKEIRVLLQERGA 100

Query: 155 QQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKL----VEEQMFSKLWEEDRL 210
           Q  R +  E  +E +         E+ +  A N  L +Q +      E + SK  E    
Sbjct: 101 QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQ 160

Query: 211 AKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQL-LKEEEARLVESNNAQIKHE 269
              +  + E  + +   E    G+ A+   ++ + Q TQ  L+E + ++ +     +  E
Sbjct: 161 KNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIE 220

Query: 270 NEQDMLKKQKAKQETRTILQKALQERIEHIQ--QEYRDEQDLNMKLVQRALQDLQEEADK 327
            E     K   K ET  +L     E IE I    +  ++  L++  ++  L++  +E   
Sbjct: 221 KE-----KIDEKSETEKLL-----EYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 270

Query: 328 KKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARR 387
            KQ  E+ I    I  K +     + +  EKE     +ED   +  E ++ L  E +  +
Sbjct: 271 LKQSLEENI---VILSKQVEDLNVKCQLLEKE-----KEDHVNRNREHNENLNAEMQNLK 322

Query: 388 QLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEY 447
           Q         + Q +EKLQ++  + +    ++K ++ SL +  C  +E   + + L +E 
Sbjct: 323 QKF-----ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEE 377

Query: 448 RKQLQMQI-AYQQQSQEAEKEEKRREFEAGVAANKMCL 484
            KQ   ++   QQ+ ++AE+  K+ E EA   A ++ L
Sbjct: 378 LKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 415


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 136/522 (26%), Positives = 236/522 (45%), Gaps = 88/522 (16%)

Query: 37   LERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEE 96
            L++IR    + + +   ++S    R KAE  + +  + L++L +  ++D +       E 
Sbjct: 1103 LKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEAL-KTELEDTLDSTAAQQEL 1161

Query: 97   RRNKLREL----LALEENEYFTEMQLKK------ETIEEKKDRMREKTKLLKEKNEKERQ 146
            R  + +E+      LEE     E Q+++      + +EE  +++ E+TK +K   EK +Q
Sbjct: 1162 RSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQL-EQTKRVKANLEKAKQ 1220

Query: 147  DFVAEKLDQQFRERCEELRVELL----SIHQKKVCEER--KAQIAFNE-ELSRQKLVE-- 197
                  L+ +  E   E++V L     S H++K  E +  + Q+ FNE E  R +L +  
Sbjct: 1221 T-----LENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275

Query: 198  -------EQMFSKLWEED----RLAKE--KREAQEARRQKELMENTR--LGLNAQITSIK 242
                   + +   L + D    +L K+    E+Q    Q+ L E  R  L L+ ++  ++
Sbjct: 1276 TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVE 1335

Query: 243  AQRQA--TQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQ---ETRTILQKALQERIE 297
             ++ +   QL +EEEA+          H    DM KK +      ET   +++ LQ+ +E
Sbjct: 1336 DEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLE 1395

Query: 298  HIQQEYRDEQDLNMKL------VQRALQDLQEEAD---------KKKQKREDMI--REQK 340
             + Q + ++     KL      +Q+ L DL  + D         +KKQK+ D +   E+ 
Sbjct: 1396 GLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKT 1455

Query: 341  IYHKYLAQR-REEEKAQEKE-----FDRILEEDKAKK--LAEKDKELRLEKEARRQLVDE 392
            I  KY  +R R E +A+EKE       R LEE   +K  L   +K+ R E E      D+
Sbjct: 1456 ISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDD 1515

Query: 393  V--------MCTRKL--QVQE-KLQREAKEQEERAMEQK--HINESLKELNCEEKENFAR 439
            V           R L  QV+E K Q E  E E +A E     +  +L+ +  + + +   
Sbjct: 1516 VGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQG 1575

Query: 440  RQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANK 481
            R   ++E +KQL  Q+    +  EAE E++R++    VAA K
Sbjct: 1576 RDEQSEEKKKQLVRQV----REMEAELEDERKQRSMAVAARK 1613



 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 127/536 (23%), Positives = 235/536 (43%), Gaps = 107/536 (19%)

Query: 29   KGQG-AEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIK-DA 86
            +G+G +EH  +++    Q+       +K +E +R++ E        + D + + +++ D 
Sbjct: 1238 QGKGDSEHKRKKVEAQLQE-----LQVKFNEGERVRTE--------LADKVTKLQVELDN 1284

Query: 87   VQGFIINIEERRNKL-RELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKER 145
            V G +   + + +KL ++  ALE     T+  L+    EE + ++   TKL + ++EK  
Sbjct: 1285 VTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ----EENRQKLSLSTKLKQVEDEKNS 1340

Query: 146  QDFVAEKLDQQFRERCEELRVELLSIH-----QKKVCEERKAQIAFNEELSRQKLVEEQM 200
                 E+L+++  E    L  ++ ++H      KK  E+    +   EE+ R+   + + 
Sbjct: 1341 ---FREQLEEE-EEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEG 1396

Query: 201  FSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSI----KAQRQATQLLKEEEA 256
             S+  EE   A +K E  + R Q+EL ++  + L+ Q  S     K Q++  QLL EE+ 
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQEL-DDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKT 1455

Query: 257  RLVESNNAQIKHENEQDMLKKQKAKQETRTI-LQKALQE------RIEHIQQEYRDEQDL 309
                      K+  E+D  + +  ++ET+ + L +AL+E       +E + +++R E + 
Sbjct: 1456 -------ISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMED 1508

Query: 310  NMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLA---QRREEEK--------AQEK 358
             M       + + E  +K K+  E  + E K   + L    Q  E+ K        A + 
Sbjct: 1509 LMSSKDDVGKSVHE-LEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567

Query: 359  EFDRILE------EDKAKKLAEKDKELRLEKE-ARRQLVDEVMCTRKLQVQ--------- 402
            +F+R L+      E+K K+L  + +E+  E E  R+Q    V   +KL++          
Sbjct: 1568 QFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHID 1627

Query: 403  -------------EKLQREAKE-----------QEERAMEQKHINESLKELNCEE---KE 435
                          KLQ + K+           +EE   + K   + LK +  E    +E
Sbjct: 1628 SANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQE 1687

Query: 436  NFA---RRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQ 488
              A   R +R AQ+ R +L  +IA          EEKRR  EA +A  +  L++ Q
Sbjct: 1688 ELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRR-LEARIAQLEEELEEEQ 1742



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 108/445 (24%), Positives = 205/445 (46%), Gaps = 66/445 (14%)

Query: 95   EERRNKLRELLALEENEYFTEMQ-LKKETIEEK---KDRMREKTKLLKEKNE-------- 142
            EE   K+RE     EN   TEM+ L+ + + EK   +++++ +T+L  E  E        
Sbjct: 851  EEELVKVREKQLAAENR-LTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAK 909

Query: 143  KERQDFVAEKLD---QQFRERCEELRVELLSIHQ--KKVCEERKAQIAFNEELSRQKLVE 197
            K+  + +   L+   ++  ERC+ L+ E   + Q  +++ E+ + + +  ++L  +K+  
Sbjct: 910  KQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTT 969

Query: 198  EQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEE-- 255
            E    KL EE+++  E +  + A+ +K L +       A+ T        T L +EEE  
Sbjct: 970  EAKLKKL-EEEQIILEDQNCKLAKEKKLLEDRI-----AEFT--------TNLTEEEEKS 1015

Query: 256  ---ARLVESNNAQIKHENEQDMLKKQKAKQE---TRTILQKALQERIEHIQQEYRDEQDL 309
               A+L   + A I  + E+ + +++K +QE   TR  L+    +  + I +      +L
Sbjct: 1016 KSLAKLKNKHEAMIT-DLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAEL 1074

Query: 310  NMKL------VQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQ----EKE 359
             M+L      +Q AL  ++EEA +K    +  IRE +     L +  E E+A     EK+
Sbjct: 1075 KMQLAKKEEELQAALARVEEEAAQKNMALK-KIRELESQISELQEDLESERASRNKAEKQ 1133

Query: 360  FDRILEEDKAKKLAEKD--------KELRLEKEAR----RQLVDEVMCTRKLQVQEKLQR 407
               + EE +A K   +D        +ELR ++E      ++ ++E   T + Q+QE  Q+
Sbjct: 1134 KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQK 1193

Query: 408  EAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQ--IAYQQQSQEAE 465
             ++  EE A + +        L   ++     R  LA E +  LQ +    ++++  EA+
Sbjct: 1194 HSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQ 1253

Query: 466  KEEKRREFEAGVAANKMCLDKVQEV 490
             +E + +F  G        DKV ++
Sbjct: 1254 LQELQVKFNEGERVRTELADKVTKL 1278



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 80/324 (24%), Positives = 149/324 (45%), Gaps = 45/324 (13%)

Query: 189  ELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQA- 247
            ++SRQ   EE+M +K   E+ L K + +   A  +   ME  +  L A+   ++ Q QA 
Sbjct: 839  QVSRQ---EEEMMAK---EEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892

Query: 248  TQLLKEEE---ARLVESNNA--QIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQE 302
            T+L  E E   ARL        +I H+ E  + ++++  Q  +   +K +Q+ I+ ++++
Sbjct: 893  TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAE-KKKMQQNIQELEEQ 951

Query: 303  YRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDR 362
              +E+    KL    L+ +  EA  KK + E +I E +       ++  E++  E   + 
Sbjct: 952  LEEEESARQKL---QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNL 1008

Query: 363  ILEEDKAKKLAE-KDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKH 421
              EE+K+K LA+ K+K              E M T    ++E+L+RE K+++E    ++ 
Sbjct: 1009 TEEEEKSKSLAKLKNKH-------------EAMIT---DLEERLRREEKQRQELEKTRRK 1052

Query: 422  INESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANK 481
            +     +L+ +  E         Q    +L+MQ+A     +E E +      E   A   
Sbjct: 1053 LEGDSTDLSDQIAE--------LQAQIAELKMQLA----KKEEELQAALARVEEEAAQKN 1100

Query: 482  MCLDKVQEVLSTHQVLPQNIHPMR 505
            M L K++E+ S    L +++   R
Sbjct: 1101 MALKKIRELESQISELQEDLESER 1124



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 101/479 (21%), Positives = 200/479 (41%), Gaps = 73/479 (15%)

Query: 44   HQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRE 103
            HQ+ +A     K  + D+L AE          +  + A+  +          E+  K   
Sbjct: 1431 HQRQSACNLEKKQKKFDQLLAE----------EKTISAKYAEERDRAEAEAREKETKALS 1480

Query: 104  LL-ALEEN-EYFTEMQ-LKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRER 160
            L  ALEE  E   E++ L K+   E +D M  K  + K  +E E+     E+  ++ + +
Sbjct: 1481 LARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQ 1540

Query: 161  CEELRVELLSIHQKKVCEERKAQIA---FNEELSRQKLVEEQMFSKLWEEDRLAKEKREA 217
             EEL  EL +    K+  E   Q     F  +L  +    E+   +L  + R  + + E 
Sbjct: 1541 LEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVR--EMEAEL 1598

Query: 218  QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKK 277
            ++ R+Q+ +    R  L   +  ++A   +    ++E  + +    AQ+K    +  L  
Sbjct: 1599 EDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRE--LDD 1656

Query: 278  QKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADK-------KKQ 330
             +A +E      K  +++++ ++ E    Q+  +   +RA +  Q+E D+          
Sbjct: 1657 TRASREEILAQAKENEKKLKSMEAEMIQLQE-ELAAAERAKRQAQQERDELADEIANSSG 1715

Query: 331  KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKK----LAEKDKELRLEKE-- 384
            K    + E++     +AQ   EE+ +E++ +  L  D+ KK    + + + +L LE+   
Sbjct: 1716 KGALALEEKRRLEARIAQL--EEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHA 1773

Query: 385  -----ARRQL----------VDEVMCTRK--------------LQVQEKLQREAKEQEER 415
                 AR+QL          + E+  T K               Q++E+L  E KE++  
Sbjct: 1774 QKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAA 1833

Query: 416  AMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIA----YQQQSQEAEKEEKR 470
              + +   + LK++  +  +     +R A++Y+ Q           ++Q +EAE+E +R
Sbjct: 1834 CKQVRRTEKKLKDVLLQVDD----ERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQR 1888



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 94/442 (21%), Positives = 191/442 (43%), Gaps = 68/442 (15%)

Query: 22   IVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRA 81
            ++ SK   G+   H LE+ +R+ ++    + +      D L+A  D     ++    ++A
Sbjct: 1509 LMSSKDDVGKSV-HELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567

Query: 82   RIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLK--- 138
            + +  +QG     EE++ +L   +   E E   E + +   +  +K ++    K L+   
Sbjct: 1568 QFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARK-KLEMDLKDLEAHI 1626

Query: 139  EKNEKERQDFVAE--KLDQQFRERCEEL------RVELLS---IHQKKVCEERKAQIAFN 187
            +   K R + + +  KL  Q ++   EL      R E+L+    ++KK+       I   
Sbjct: 1627 DSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQ 1686

Query: 188  EELSRQKLVEEQMFSKLWEEDRLA----------------KEKREAQEARRQKELMENTR 231
            EEL+  +  + Q      E D LA                K + EA+ A+ ++EL E   
Sbjct: 1687 EELAAAERAKRQAQQ---ERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQG 1743

Query: 232  LGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKA 291
               N ++ + + ++   Q+ +      +E ++AQ K+EN +  L++Q           K 
Sbjct: 1744 ---NTELINDRLKKANLQIDQINTDLNLERSHAQ-KNENARQQLERQ----------NKE 1789

Query: 292  LQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRRE 351
            L+ +++ ++   + +   ++  ++  +  L+E+ D + ++R+   ++          RR 
Sbjct: 1790 LKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQ---------VRRT 1840

Query: 352  EEKAQEKEFDRILEEDKAKKLAEK-----DKELRLEKEARRQLVD-EVMCTRKLQVQEKL 405
            E+K +    D +L+ D  ++ AE+     DK     K+ +RQL + E    R    + KL
Sbjct: 1841 EKKLK----DVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKL 1896

Query: 406  QREAKEQEERAMEQKHINESLK 427
            QRE ++  E A        SLK
Sbjct: 1897 QRELEDATETADAMNREVSSLK 1918



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 49/211 (23%), Positives = 103/211 (48%), Gaps = 18/211 (8%)

Query: 274 MLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKRE 333
           + +K  AK++ +    K LQ        + R+ Q   +    + L  +  + ++   K E
Sbjct: 794 LARKAFAKRQQQLTAMKVLQRNCA-AYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEE 852

Query: 334 DMIREQKIYHKYLAQRR---EEEKAQEK---EFDRILEEDKAK-KLAEKDKELRLEKEAR 386
           +++   K+  K LA      E E  Q +   E  ++ E+ +A+ +L  + +ELR    A+
Sbjct: 853 ELV---KVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAK 909

Query: 387 RQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQ- 445
           +Q ++E+    + +V+E+ +R    Q E+   Q++I E  ++L  EE+E+  ++ +L + 
Sbjct: 910 KQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL--EEEESARQKLQLEKV 967

Query: 446 ----EYRKQLQMQIAYQQQSQEAEKEEKRRE 472
               + +K  + QI  + Q+ +  KE+K  E
Sbjct: 968 TTEAKLKKLEEEQIILEDQNCKLAKEKKLLE 998



 Score = 32.7 bits (73), Expect = 0.81
 Identities = 39/167 (23%), Positives = 76/167 (45%), Gaps = 33/167 (19%)

Query: 346 LAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKL 405
           ++++ EE  A+E+E  ++ E    K+LA +++   +E   + QL+ E     KLQ+QE+L
Sbjct: 840 VSRQEEEMMAKEEELVKVRE----KQLAAENRLTEMET-LQSQLMAE-----KLQLQEQL 889

Query: 406 QREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAE 465
           Q E +                    C E E    R RL    +KQ   +I +  +++  E
Sbjct: 890 QAETEL-------------------CAEAEEL--RARLTA--KKQELEEICHDLEARVEE 926

Query: 466 KEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNIHPMRKACPSKL 512
           +EE+ +  +A     +  + +++E L   +   Q +   +    +KL
Sbjct: 927 EEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKL 973


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 87/387 (22%), Positives = 175/387 (45%), Gaps = 23/387 (5%)

Query: 102 RELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRER 160
           RE    +E E   E +  +   + K++R REK +  K    +ERQ D   E+  Q  RER
Sbjct: 54  RERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRER 113

Query: 161 CEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEA 220
             +   E     +++   ER+ +   + +   Q+  E Q  ++   E +  +E++   E 
Sbjct: 114 DRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTER 173

Query: 221 RRQKEL---------MENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENE 271
            RQKE           E  R       T  +   +  +  +E E         Q   E +
Sbjct: 174 NRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERD 233

Query: 272 -QDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQ 330
            Q   ++++ KQ  R    +   ER +  ++E   ++D + +  +R     + + D+K+Q
Sbjct: 234 RQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKER-----ERQTDRKRQ 288

Query: 331 KREDMIRE-QKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQL 389
           +R +  RE ++   +   + RE E+ +++E +R  E ++ ++  E +++   E+E +R+ 
Sbjct: 289 RRTERDRETERKRERQRERERERERNRKRERERERERERERQ-RETERDREKERERKRKR 347

Query: 390 VDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRK 449
             E+   R  Q   + +R+A+ + ER  E++   +S +E    E++    RQ+   E  +
Sbjct: 348 QTEMDRERNRQTGREGRRQAERERER--ERERDRQSAREREERERDRDRDRQK---ERER 402

Query: 450 QLQMQIAYQQQSQEAEKEEKRREFEAG 476
           Q +     Q+++++  + EK RE E G
Sbjct: 403 QTEKDRDGQRETEKQREREKDRESERG 429



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 88/422 (20%), Positives = 186/422 (44%), Gaps = 42/422 (9%)

Query: 34  EHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIIN 93
           + H +R R   ++ +      + ++R+R +    + N  K  +   R   ++  +G    
Sbjct: 86  DRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERE---RETEREGERGRDRQ 142

Query: 94  IEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKL 153
            + +R + R+  A +E E  T+ + +++T E  + + RE+ K  +E+ E+ERQ     K 
Sbjct: 143 TDGQRERERQRDAEKERERQTDRERQRQT-ERNRQKEREREKNRQERRERERQREKENKT 201

Query: 154 DQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKE 213
           + +  ER  E   E     + +   ERK Q   + E  RQ+  E +       E +  +E
Sbjct: 202 EDRHSERGRERERE----RETETETERKRQT--DRERDRQRKTERE------REKQAERE 249

Query: 214 KREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQD 273
           +   +E  R KE  E  R             R   +  KE E +       + + + E +
Sbjct: 250 RASERETERDKE-RERER----------DRDRDRDRRQKERERQTDRKRQRRTERDRETE 298

Query: 274 MLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKRE 333
             ++++ ++E         +ER  + ++E   E++   +  +   +D ++E ++K++++ 
Sbjct: 299 RKRERQRERE---------RERERNRKRERERERERERERQRETERDREKERERKRKRQT 349

Query: 334 DMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEV 393
           +M RE+         RR+ E+ +E+E +R  +  + ++  E+D++   +KE  RQ   + 
Sbjct: 350 EMDRERN-RQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDR 408

Query: 394 MCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM 453
              R+ + Q   +RE   + ER  E+    E  K     E++   +  R A   RK+  +
Sbjct: 409 DGQRETEKQR--EREKDRESERGRERGREREKQKG---RERDRERQTDRQAGRQRKRSTL 463

Query: 454 QI 455
            +
Sbjct: 464 YV 465



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 36/154 (23%), Positives = 78/154 (50%), Gaps = 9/154 (5%)

Query: 323 EEADKKKQKREDMIREQKIYHKYLAQRRE--EEKAQEKEFDRILEEDKAKKLAEKDKELR 380
           ++ ++ +QK  +  RE++   +   ++RE   EK + ++ DR  E  + +   EK++E +
Sbjct: 52  DDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDR---EKERERQ 108

Query: 381 LEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARR 440
            ++E  RQ   E    R+ + + + +RE +   +R  + +   E  ++   +E+E    R
Sbjct: 109 TDRERDRQREKE--RNRQKERERETEREGERGRDRQTDGQRERERQRDAE-KERERQTDR 165

Query: 441 QRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFE 474
           +R  Q  R + Q +   ++  QE  + E++RE E
Sbjct: 166 ERQRQTERNR-QKEREREKNRQERRERERQREKE 198


>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 83/353 (23%), Positives = 188/353 (53%), Gaps = 36/353 (10%)

Query: 135 KLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQK 194
           KL KE++    + +     D++ +E+  EL+ +L      ++ E  K++I  N +  ++K
Sbjct: 194 KLTKERDAPSLELYRNTITDEELKEKNAELQEKL------RLVESEKSEIQLNVKDLKRK 247

Query: 195 LVEEQMFSKLW----EEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQL 250
           L   Q+         E DRL KE +    A+ Q ++ EN    L  Q    K  RQ  ++
Sbjct: 248 LERAQLLLPQQQLQVEADRLGKELQSVS-AKLQAQVEENELWNLLNQQQEEKMWRQEEKI 306

Query: 251 LKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKA-----LQERIEHIQQEYRD 305
            +E+E ++ E    +I+ + E+   +++K  ++   I ++       +E+I   +++ R+
Sbjct: 307 -QEQEEKMCEQE-LKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIRE 364

Query: 306 EQDLNMKLVQRALQDLQEEADKKKQKREDMIR-EQKIYHKYLAQRREEEKAQEK---EFD 361
           +++     + R  + ++E+ +K +++ E+M R E+KI       R +EEK QEK   +  
Sbjct: 365 QEEK----MWRQEEKIREQDEKIQEQEEEMWRQEEKI-------REQEEKRQEKMWRQEK 413

Query: 362 RILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKH 421
           ++ E+D  +K+ E+++E+  ++E  R+L +E+M  ++ +++E  ++  +E+E+   +++ 
Sbjct: 414 KMREQD--EKIREQEEEMWRQEEKIREL-EEMMQDQEEKLREVEEKMQEEEEKMQEQEEK 470

Query: 422 INESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFE 474
           I    +++  +E++ + + + L QE +   Q +  ++Q+ +  E+EEK +E E
Sbjct: 471 IQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQE 523



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 89/401 (22%), Positives = 198/401 (49%), Gaps = 47/401 (11%)

Query: 93  NIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEK 152
           ++E  RN + +    E+N    E+Q K   +E +K  ++   K LK K E+      A+ 
Sbjct: 203 SLELYRNTITDEELKEKN---AELQEKLRLVESEKSEIQLNVKDLKRKLER------AQL 253

Query: 153 L--DQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRL 210
           L   QQ +   + L  EL S+  K      +AQ+  NE  +   L+ +Q   K+W ++  
Sbjct: 254 LLPQQQLQVEADRLGKELQSVSAKL-----QAQVEENELWN---LLNQQQEEKMWRQEEK 305

Query: 211 AKEKREAQ-----EARRQKELMENTRLGLNAQITSIKAQR----QATQLLKEEEARLVES 261
            +E+ E       + R Q+E M      ++ Q   I+ Q     +  + ++E+E +    
Sbjct: 306 IQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEK---- 361

Query: 262 NNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDL 321
               I+ + E+   +++K +++   I ++  +E +   +++ R++++   + + R  + +
Sbjct: 362 ----IREQEEKMWRQEEKIREQDEKIQEQ--EEEMWRQEEKIREQEEKRQEKMWRQEKKM 415

Query: 322 QEEADKKKQKREDMIR-EQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELR 380
           +E+ +K +++ E+M R E+KI       + +EEK +E E +++ EE+  +K+ E++++++
Sbjct: 416 REQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE-EKMQEEE--EKMQEQEEKIQ 472

Query: 381 LEKEARRQLVDEVMCTRKLQVQEKLQREAKE----QEERAMEQKH-INESLKELNCEEKE 435
            ++E  ++  ++     KL  QE+   E +E    QEE+  EQ+  + E  +++  +E++
Sbjct: 473 RQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEK 532

Query: 436 NFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAG 476
              +  RL Q+  K  + ++  Q+  +   K  ++ E   G
Sbjct: 533 MREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGG 573



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 74/350 (21%), Positives = 179/350 (51%), Gaps = 29/350 (8%)

Query: 92  INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE-RQDFVA 150
           +  +   N+L  LL  ++ E   +M  ++E I+E++++M E+   ++E+ EK  RQ+   
Sbjct: 278 LQAQVEENELWNLLNQQQEE---KMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKM 334

Query: 151 EKLDQQFRERCEEL--RVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
            + +++ RE+ +++  + E +   ++K+ E+ +      E++  Q    ++   ++W ++
Sbjct: 335 HEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQE 394

Query: 209 RLAKEKREAQEAR--RQKELMENTRLGLNAQITSIKAQ----RQATQLLKEEEARLVE-- 260
              +E+ E ++ +  RQ++ M      +  Q   +  Q    R+  ++++++E +L E  
Sbjct: 395 EKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454

Query: 261 --SNNAQIKHENEQDMLKKQKAK---QETRTILQKALQERIEHIQQEYRDEQDLNMKLVQ 315
                 + K + +++ +++Q+ K   QE +T  Q+ L ++ E I ++         K+ +
Sbjct: 455 EKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWE 514

Query: 316 RALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEK 375
           +  ++  +E ++K Q++E+ +REQ++        ++EEK QE+E      E++  KL +K
Sbjct: 515 Q--EEKMQEQEEKMQRQEEKMREQEV-----RLWQQEEKMQEQEVRLQELEERLGKLGQK 567

Query: 376 DKEL-RLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINE 424
            + L    +E+  Q +  +  T  LQV+ K Q     Q+++   + H+ +
Sbjct: 568 AELLGGAGRESGSQRLPTL--TPILQVELKSQEAQSLQQQQDHYRGHLQQ 615



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 95/419 (22%), Positives = 194/419 (46%), Gaps = 50/419 (11%)

Query: 110 NEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELL 169
           +E F ++   +  +E +K R  ++     +  E E      E L +      ++  +E  
Sbjct: 60  DEKFFQLSEMEAYLENRKRRGTKRWDEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDA 119

Query: 170 SI-HQKKVCEE-----RKAQIAFNEE--LSRQKLVEEQMFSKLWE-------EDRLAKEK 214
            + H KK  +E     +K Q   NE+    R+++V ++ + +L E       E+ L +E 
Sbjct: 120 GVSHVKKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEET 179

Query: 215 REAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEA------RLVESNNAQIKH 268
                A R    +E      +A    +       + LKE+ A      RLVES  ++I+ 
Sbjct: 180 LHFDHAVRMGTYIEKLTKERDAPSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQ- 238

Query: 269 ENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQD-----LQE 323
            N +D+  K+K ++    + Q+ LQ   + + +E    Q ++ KL  +  ++     L +
Sbjct: 239 LNVKDL--KRKLERAQLLLPQQQLQVEADRLGKEL---QSVSAKLQAQVEENELWNLLNQ 293

Query: 324 EADKKKQKREDMIREQ--KIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
           + ++K  ++E+ I+EQ  K+  + L  R +EEK   +E     +E+K ++  ++DK  R 
Sbjct: 294 QQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIRE--QEDKMWRQ 351

Query: 382 EKEARRQLVDEVMCTRKLQVQE----KLQREAKEQEERAMEQKHINESLKELNCEEKENF 437
           E++ R Q         K++ QE    + + + +EQ+E+  EQ+      +E   E++E  
Sbjct: 352 EEKIREQ-------EEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEK- 403

Query: 438 ARRQRLAQEYRKQLQMQIAYQQQSQEA-EKEEKRREFEAGVAANKMCLDKVQEVLSTHQ 495
            R++++ ++ +K  +     ++Q +E   +EEK RE E  +   +  L +V+E +   +
Sbjct: 404 -RQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEE 461


>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 83/353 (23%), Positives = 188/353 (53%), Gaps = 36/353 (10%)

Query: 135 KLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQK 194
           KL KE++    + +     D++ +E+  EL+ +L      ++ E  K++I  N +  ++K
Sbjct: 194 KLTKERDALSLELYRNTITDEELKEKNAELQEKL------RLVESEKSEIQLNVKDLKRK 247

Query: 195 LVEEQMFSKLW----EEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQL 250
           L   Q+         E DRL KE +    A+ Q ++ EN    L  Q    K  RQ  ++
Sbjct: 248 LERAQLLLPQQQLQVEADRLGKELQSVS-AKLQAQVEENELWNLLNQQQEEKMWRQEEKI 306

Query: 251 LKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKA-----LQERIEHIQQEYRD 305
            +E+E ++ E    +I+ + E+   +++K  ++   I ++       +E+I   +++ R+
Sbjct: 307 -QEQEEKMCEQE-LKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIRE 364

Query: 306 EQDLNMKLVQRALQDLQEEADKKKQKREDMIR-EQKIYHKYLAQRREEEKAQEK---EFD 361
           +++     + R  + ++E+ +K +++ E+M R E+KI       R +EEK QEK   +  
Sbjct: 365 QEEK----MWRQEEKIREQDEKIQEQEEEMWRQEEKI-------REQEEKRQEKMWRQEK 413

Query: 362 RILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKH 421
           ++ E+D  +K+ E+++E+  ++E  R+L +E+M  ++ +++E  ++  +E+E+   +++ 
Sbjct: 414 KMREQD--EKIREQEEEMWRQEEKIREL-EEMMQDQEEKLREVEEKMQEEEEKMQEQEEK 470

Query: 422 INESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFE 474
           I    +++  +E++ + + + L QE +   Q +  ++Q+ +  E+EEK +E E
Sbjct: 471 IQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQE 523



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 89/402 (22%), Positives = 199/402 (49%), Gaps = 47/402 (11%)

Query: 92  INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAE 151
           +++E  RN + +    E+N    E+Q K   +E +K  ++   K LK K E+      A+
Sbjct: 202 LSLELYRNTITDEELKEKN---AELQEKLRLVESEKSEIQLNVKDLKRKLER------AQ 252

Query: 152 KL--DQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDR 209
            L   QQ +   + L  EL S+  K      +AQ+  NE  +   L+ +Q   K+W ++ 
Sbjct: 253 LLLPQQQLQVEADRLGKELQSVSAKL-----QAQVEENELWN---LLNQQQEEKMWRQEE 304

Query: 210 LAKEKREAQ-----EARRQKELMENTRLGLNAQITSIKAQR----QATQLLKEEEARLVE 260
             +E+ E       + R Q+E M      ++ Q   I+ Q     +  + ++E+E +   
Sbjct: 305 KIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEK--- 361

Query: 261 SNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQD 320
                I+ + E+   +++K +++   I ++  +E +   +++ R++++   + + R  + 
Sbjct: 362 -----IREQEEKMWRQEEKIREQDEKIQEQ--EEEMWRQEEKIREQEEKRQEKMWRQEKK 414

Query: 321 LQEEADKKKQKREDMIR-EQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKEL 379
           ++E+ +K +++ E+M R E+KI       + +EEK +E E +++ EE+  +K+ E+++++
Sbjct: 415 MREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE-EKMQEEE--EKMQEQEEKI 471

Query: 380 RLEKEARRQLVDEVMCTRKLQVQEKLQREAKE----QEERAMEQKH-INESLKELNCEEK 434
           + ++E  ++  ++     KL  QE+   E +E    QEE+  EQ+  + E  +++  +E+
Sbjct: 472 QRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEE 531

Query: 435 ENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAG 476
           +   +  RL Q+  K  + ++  Q+  +   K  ++ E   G
Sbjct: 532 KMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGG 573



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 74/350 (21%), Positives = 179/350 (51%), Gaps = 29/350 (8%)

Query: 92  INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE-RQDFVA 150
           +  +   N+L  LL  ++ E   +M  ++E I+E++++M E+   ++E+ EK  RQ+   
Sbjct: 278 LQAQVEENELWNLLNQQQEE---KMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKM 334

Query: 151 EKLDQQFRERCEEL--RVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
            + +++ RE+ +++  + E +   ++K+ E+ +      E++  Q    ++   ++W ++
Sbjct: 335 HEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQE 394

Query: 209 RLAKEKREAQEAR--RQKELMENTRLGLNAQITSIKAQ----RQATQLLKEEEARLVE-- 260
              +E+ E ++ +  RQ++ M      +  Q   +  Q    R+  ++++++E +L E  
Sbjct: 395 EKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454

Query: 261 --SNNAQIKHENEQDMLKKQKAK---QETRTILQKALQERIEHIQQEYRDEQDLNMKLVQ 315
                 + K + +++ +++Q+ K   QE +T  Q+ L ++ E I ++         K+ +
Sbjct: 455 EKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWE 514

Query: 316 RALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEK 375
           +  ++  +E ++K Q++E+ +REQ++        ++EEK QE+E      E++  KL +K
Sbjct: 515 Q--EEKMQEQEEKMQRQEEKMREQEV-----RLWQQEEKMQEQEVRLQELEERLGKLGQK 567

Query: 376 DKEL-RLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINE 424
            + L    +E+  Q +  +  T  LQV+ K Q     Q+++   + H+ +
Sbjct: 568 AELLGGAGRESGSQRLPTL--TPILQVELKSQEAQSLQQQQDHYRGHLQQ 615



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 95/419 (22%), Positives = 194/419 (46%), Gaps = 50/419 (11%)

Query: 110 NEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELL 169
           +E F ++   +  +E +K R  ++     +  E E      E L +      ++  +E  
Sbjct: 60  DEKFFQLSEMEAYLENRKRRGTKRWDEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDA 119

Query: 170 SI-HQKKVCEE-----RKAQIAFNEE--LSRQKLVEEQMFSKLWE-------EDRLAKEK 214
            + H KK  +E     +K Q   NE+    R+++V ++ + +L E       E+ L +E 
Sbjct: 120 GVSHVKKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEET 179

Query: 215 REAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEA------RLVESNNAQIKH 268
                A R    +E      +A    +       + LKE+ A      RLVES  ++I+ 
Sbjct: 180 LHFDHAVRMGTYIEKLTKERDALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQ- 238

Query: 269 ENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQD-----LQE 323
            N +D+  K+K ++    + Q+ LQ   + + +E    Q ++ KL  +  ++     L +
Sbjct: 239 LNVKDL--KRKLERAQLLLPQQQLQVEADRLGKEL---QSVSAKLQAQVEENELWNLLNQ 293

Query: 324 EADKKKQKREDMIREQ--KIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
           + ++K  ++E+ I+EQ  K+  + L  R +EEK   +E     +E+K ++  ++DK  R 
Sbjct: 294 QQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIRE--QEDKMWRQ 351

Query: 382 EKEARRQLVDEVMCTRKLQVQE----KLQREAKEQEERAMEQKHINESLKELNCEEKENF 437
           E++ R Q         K++ QE    + + + +EQ+E+  EQ+      +E   E++E  
Sbjct: 352 EEKIREQ-------EEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEK- 403

Query: 438 ARRQRLAQEYRKQLQMQIAYQQQSQEA-EKEEKRREFEAGVAANKMCLDKVQEVLSTHQ 495
            R++++ ++ +K  +     ++Q +E   +EEK RE E  +   +  L +V+E +   +
Sbjct: 404 -RQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEE 461


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.127    0.334 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,072,044
Number of Sequences: 37866
Number of extensions: 900663
Number of successful extensions: 27887
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 546
Number of HSP's successfully gapped in prelim test: 1396
Number of HSP's that attempted gapping in prelim test: 6433
Number of HSP's gapped (non-prelim): 8353
length of query: 514
length of database: 18,247,518
effective HSP length: 107
effective length of query: 407
effective length of database: 14,195,856
effective search space: 5777713392
effective search space used: 5777713392
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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