Guide to the Human Genome
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Search of human proteins with 94721253

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|94721253 solute carrier family 26, member 6 isoform 1 [Homo
sapiens]
         (759 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|94721253 solute carrier family 26, member 6 isoform 1 [Homo s...  1478   0.0  
gi|94721255 solute carrier family 26, member 6 isoform 2 [Homo s...  1471   0.0  
gi|94721259 solute carrier family 26, member 6 isoform 4 [Homo s...  1439   0.0  
gi|94721257 solute carrier family 26, member 6 isoform 3 [Homo s...  1407   0.0  
gi|39752683 prestin isoform a [Homo sapiens]                          560   e-159
gi|4505697 pendrin [Homo sapiens]                                     550   e-156
gi|45827800 prestin isoform b [Homo sapiens]                          540   e-153
gi|16418413 solute carrier family 26, member 9 isoform a [Homo s...   504   e-142
gi|217272867 solute carrier family 26, member 9 isoform b [Homo ...   504   e-142
gi|4557535 solute carrier family 26, member 3 [Homo sapiens]          499   e-141
gi|45827802 prestin isoform c [Homo sapiens]                          450   e-126
gi|47131207 solute carrier family 26, member 1 isoform a [Homo s...   405   e-113
gi|20336272 solute carrier family 26, member 1 isoform a [Homo s...   405   e-113
gi|100913030 solute carrier family 26 member 2 [Homo sapiens]         404   e-112
gi|16418457 solute carrier family 26, member 8 isoform a [Homo s...   373   e-103
gi|16306483 solute carrier family 26, member 7 isoform a [Homo s...   307   2e-83
gi|20336282 solute carrier family 26, member 7 isoform b [Homo s...   307   2e-83
gi|65506789 solute carrier family 26, member 10 [Homo sapiens]        279   8e-75
gi|217272870 solute carrier family 26, member 9 isoform c [Homo ...   259   5e-69
gi|45827804 prestin isoform d [Homo sapiens]                          248   1e-65
gi|20336285 solute carrier family 26, member 8 isoform b [Homo s...   234   2e-61
gi|85540447 solute carrier family 26, member 11 [Homo sapiens]        226   6e-59
gi|20336274 solute carrier family 26, member 1 isoform b [Homo s...   115   2e-25
gi|116256458 hypothetical protein LOC121053 [Homo sapiens]             35   0.34 
gi|62422577 neurobeachin [Homo sapiens]                                33   1.3  
gi|40068059 CBF1 interacting corepressor [Homo sapiens]                32   1.7  
gi|55749531 splicing factor 3B subunit 2 [Homo sapiens]                32   1.7  
gi|157649069 ATPase, aminophospholipid transporter (APLT), class...    32   2.2  
gi|17978471 ATPase, aminophospholipid transporter (APLT), class ...    32   2.2  
gi|45827729 scribble isoform b [Homo sapiens]                          32   2.2  

>gi|94721253 solute carrier family 26, member 6 isoform 1 [Homo
           sapiens]
          Length = 759

 Score = 1478 bits (3826), Expect = 0.0
 Identities = 759/759 (100%), Positives = 759/759 (100%)

Query: 1   MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL 60
           MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL
Sbjct: 1   MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL 60

Query: 61  QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV 120
           QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV
Sbjct: 61  QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV 120

Query: 121 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR 180
           FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR
Sbjct: 121 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR 180

Query: 181 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS 240
           VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS
Sbjct: 181 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS 240

Query: 241 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL 300
           SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL
Sbjct: 241 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL 300

Query: 301 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI 360
           TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI
Sbjct: 301 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI 360

Query: 361 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA 420
           SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA
Sbjct: 361 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA 420

Query: 421 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT 480
           ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT
Sbjct: 421 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT 480

Query: 481 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV 540
           FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV
Sbjct: 481 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV 540

Query: 541 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ 600
           KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ
Sbjct: 541 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ 600

Query: 601 AASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKA 660
           AASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKA
Sbjct: 601 AASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKA 660

Query: 661 LGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGH 720
           LGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGH
Sbjct: 661 LGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGH 720

Query: 721 FFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL 759
           FFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
Sbjct: 721 FFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL 759


>gi|94721255 solute carrier family 26, member 6 isoform 2 [Homo
           sapiens]
          Length = 758

 Score = 1471 bits (3809), Expect = 0.0
 Identities = 758/759 (99%), Positives = 758/759 (99%), Gaps = 1/759 (0%)

Query: 1   MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL 60
           MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL
Sbjct: 1   MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL 60

Query: 61  QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV 120
           QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV
Sbjct: 61  QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV 120

Query: 121 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR 180
           FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR
Sbjct: 121 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR 180

Query: 181 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS 240
           VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS
Sbjct: 181 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS 240

Query: 241 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL 300
           SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL
Sbjct: 241 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL 300

Query: 301 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI 360
           TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI
Sbjct: 301 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI 360

Query: 361 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA 420
           SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA
Sbjct: 361 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA 420

Query: 421 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT 480
           ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT
Sbjct: 421 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT 480

Query: 481 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV 540
           FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV
Sbjct: 481 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV 540

Query: 541 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ 600
           KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ
Sbjct: 541 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ 600

Query: 601 AASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKA 660
           AASPKGASVSINVNTSLEDMRSNNVEDCKMM VSSGDKMEDATANGQEDSKAPDGSTLKA
Sbjct: 601 AASPKGASVSINVNTSLEDMRSNNVEDCKMM-VSSGDKMEDATANGQEDSKAPDGSTLKA 659

Query: 661 LGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGH 720
           LGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGH
Sbjct: 660 LGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGH 719

Query: 721 FFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL 759
           FFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
Sbjct: 720 FFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL 758


>gi|94721259 solute carrier family 26, member 6 isoform 4 [Homo
           sapiens]
          Length = 738

 Score = 1439 bits (3725), Expect = 0.0
 Identities = 738/738 (100%), Positives = 738/738 (100%)

Query: 22  MDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWL 81
           MDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWL
Sbjct: 1   MDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWL 60

Query: 82  PRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRH 141
           PRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRH
Sbjct: 61  PRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRH 120

Query: 142 ISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLI 201
           ISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLI
Sbjct: 121 ISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLI 180

Query: 202 HFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQ 261
           HFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQ
Sbjct: 181 HFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQ 240

Query: 262 SKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVD 321
           SKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVD
Sbjct: 241 SKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVD 300

Query: 322 VVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELV 381
           VVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELV
Sbjct: 301 VVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELV 360

Query: 382 ALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLP 441
           ALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLP
Sbjct: 361 ALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLP 420

Query: 442 KAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSL 501
           KAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSL
Sbjct: 421 KAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSL 480

Query: 502 LLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDAL 561
           LLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDAL
Sbjct: 481 LLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDAL 540

Query: 562 KQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMR 621
           KQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMR
Sbjct: 541 KQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMR 600

Query: 622 SNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFV 681
           SNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFV
Sbjct: 601 SNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFV 660

Query: 682 DTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHDAVTF 741
           DTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHDAVTF
Sbjct: 661 DTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHDAVTF 720

Query: 742 ALQHPRPVPDSPVSVTRL 759
           ALQHPRPVPDSPVSVTRL
Sbjct: 721 ALQHPRPVPDSPVSVTRL 738


>gi|94721257 solute carrier family 26, member 6 isoform 3 [Homo
           sapiens]
          Length = 740

 Score = 1407 bits (3642), Expect = 0.0
 Identities = 730/759 (96%), Positives = 732/759 (96%), Gaps = 19/759 (2%)

Query: 1   MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL 60
           MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL
Sbjct: 1   MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL 60

Query: 61  QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV 120
           QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV
Sbjct: 61  QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV 120

Query: 121 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR 180
           FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR
Sbjct: 121 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR 180

Query: 181 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS 240
           VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS
Sbjct: 181 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS 240

Query: 241 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL 300
           SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL
Sbjct: 241 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL 300

Query: 301 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI 360
           TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI
Sbjct: 301 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI 360

Query: 361 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA 420
           SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA
Sbjct: 361 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA 420

Query: 421 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT 480
           ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT
Sbjct: 421 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT 480

Query: 481 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV 540
           FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV
Sbjct: 481 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV 540

Query: 541 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ 600
           KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ
Sbjct: 541 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ 600

Query: 601 AASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKA 660
           A     A ++                     QVSSGDKMEDATANGQEDSKAPDGSTLKA
Sbjct: 601 AGPLLSACLA-------------------PQQVSSGDKMEDATANGQEDSKAPDGSTLKA 641

Query: 661 LGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGH 720
           LGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGH
Sbjct: 642 LGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGH 701

Query: 721 FFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL 759
           FFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
Sbjct: 702 FFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL 740


>gi|39752683 prestin isoform a [Homo sapiens]
          Length = 744

 Score =  560 bits (1442), Expect = e-159
 Identities = 300/742 (40%), Positives = 456/742 (61%), Gaps = 57/742 (7%)

Query: 15  LLSATQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWRTWLQCSRARAYALL 71
           +L+ATQ        Y++ERP+ +   L+E L      P +   + +    C+  +   ++
Sbjct: 9   ILAATQR-------YYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNII 61

Query: 72  LQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVF 131
              LP+  WLP Y  ++++LGDL+SG+S  ++QLPQGLA+A+LA +PP+FGLYSSFYPV 
Sbjct: 62  YMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVI 121

Query: 132 IYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET----ARDAARVQVAST 186
           +Y   GTSRHIS+G FAV+S+M+G V   L P  +     +N T    ARDA RV+VA +
Sbjct: 122 MYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMS 181

Query: 187 LSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPL 246
           +++L G+ Q  LG+  FGFV  YL+EPLVRG+TTAAAV VF S LKY+FG+    +SG  
Sbjct: 182 VTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIF 241

Query: 247 SLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGAT 306
           S++Y+ + V   +    V ++    +   +L+  K  N++ +++LP PIP E   ++  T
Sbjct: 242 SVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGT 301

Query: 307 GISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIF 366
           GIS G  LK  + VDVVG +P GL+PP  P+T LF  +   A  IA+VGF++ IS+ K  
Sbjct: 302 GISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTL 361

Query: 367 ALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFI 426
           A +HGY+VD NQEL+ALGL N IG +FQ F +SCS+SRSLVQE TGG +Q+AG ++SL I
Sbjct: 362 ANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMI 421

Query: 427 LLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATIL 486
           LL+I+  G LF  LP+AVL+AI+IVNLKGM  Q SD+   W+ ++ +L IWL TF +++ 
Sbjct: 422 LLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLF 481

Query: 487 LNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSS 546
           L LD GL+ AVI +LL V+ RTQ P Y VLG++P+TD+Y D+  Y E KE+ G+K+F+ +
Sbjct: 482 LGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQIN 541

Query: 547 ATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKG 606
           A +Y+AN++ YS+ALK++ GV+   ++  ++K ++K                        
Sbjct: 542 APIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKY----------------------- 578

Query: 607 ASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDS---------KAPDGST 657
                      +++ + N+ +  +++  +    EDAT   +ED          K+     
Sbjct: 579 ----------AKEVGNANMANATVVKADAEVDGEDATKPEEEDGEVKYPPIVIKSTFPEE 628

Query: 658 LKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLE 717
           ++    P  + H++ILD   ++F+D+V +K+L  I  ++ ++ + VY+A C + VV+ L 
Sbjct: 629 MQRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLT 688

Query: 718 AGHFFDASITKKHLFASVHDAV 739
              FF+     + LF S+HDAV
Sbjct: 689 RNRFFENPALWELLFHSIHDAV 710


>gi|4505697 pendrin [Homo sapiens]
          Length = 780

 Score =  550 bits (1416), Expect = e-156
 Identities = 284/691 (41%), Positives = 438/691 (63%), Gaps = 29/691 (4%)

Query: 62  CSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVF 121
           CSR RA+ +L   +P+L WLP+Y V++WLL D++SG+S  ++   QG+AYALLA +P  +
Sbjct: 56  CSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGY 115

Query: 122 GLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQ-----------ALNDSM 170
           GLYS+F+P+  YF+FGTSRHISVG F V+S+MVGSV  S+AP             LN +M
Sbjct: 116 GLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTM 175

Query: 171 INETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQ 230
           I+  ARD ARV +AS L++LVG+ Q+  G +  GF+V YL++PLV G+TTAAA QV VSQ
Sbjct: 176 IDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQ 235

Query: 231 LKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQ 290
           LK V  +   +++G LS+IYT++E+   +  + +       +  VV + VK LND+ + +
Sbjct: 236 LKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHK 295

Query: 291 LPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFT 350
           +P+PIP E++  I AT ISYG  L+  +   +V +IP G +PP  P   LFS+++ ++F+
Sbjct: 296 IPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFS 355

Query: 351 IAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQES 410
           IAVV +AIA+S+GK++A ++ Y +D NQE +A G+SN+  G F CF  + ++SR+ VQES
Sbjct: 356 IAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQES 415

Query: 411 TGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKAN 470
           TGG +QVAG IS+  +++ I+ LG+L   L K+VLAA++I NLKGM  QL D+  LW+ N
Sbjct: 416 TGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQN 475

Query: 471 RADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAE 530
           + D +IW+ T   +I+L LDLGL+  +IF LL VV+R Q P ++ LG +P TDIY+    
Sbjct: 476 KIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKN 535

Query: 531 YSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQ 590
           Y   +E +GVK+ R S+ +++ N + +   +K   G D   + +++ K L+     K+++
Sbjct: 536 YKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALR-----KIQK 590

Query: 591 LQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDS 650
           L K  +LR    + K   +S  V+T+       ++ED + + + + +       N +   
Sbjct: 591 LIKSGQLR----ATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPV 646

Query: 651 KAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHS 710
           K         + +P+   HSL+LD GA+SF+D V ++SL+ I  +F+ I+V VY A+   
Sbjct: 647 K---------VNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQD 697

Query: 711 PVVSQLEAGHFFDASITKKHLFASVHDAVTF 741
            V+ +LE   FFD +I K   F +VHDA+ +
Sbjct: 698 YVIEKLEQCGFFDDNIRKDTFFLTVHDAILY 728


>gi|45827800 prestin isoform b [Homo sapiens]
          Length = 685

 Score =  540 bits (1391), Expect = e-153
 Identities = 288/711 (40%), Positives = 439/711 (61%), Gaps = 57/711 (8%)

Query: 15  LLSATQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWRTWLQCSRARAYALL 71
           +L+ATQ        Y++ERP+ +   L+E L      P +   + +    C+  +   ++
Sbjct: 9   ILAATQR-------YYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNII 61

Query: 72  LQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVF 131
              LP+  WLP Y  ++++LGDL+SG+S  ++QLPQGLA+A+LA +PP+FGLYSSFYPV 
Sbjct: 62  YMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVI 121

Query: 132 IYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET----ARDAARVQVAST 186
           +Y   GTSRHIS+G FAV+S+M+G V   L P  +     +N T    ARDA RV+VA +
Sbjct: 122 MYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMS 181

Query: 187 LSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPL 246
           +++L G+ Q  LG+  FGFV  YL+EPLVRG+TTAAAV VF S LKY+FG+    +SG  
Sbjct: 182 VTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIF 241

Query: 247 SLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGAT 306
           S++Y+ + V   +    V ++    +   +L+  K  N++ +++LP PIP E   ++  T
Sbjct: 242 SVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGT 301

Query: 307 GISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIF 366
           GIS G  LK  + VDVVG +P GL+PP  P+T LF  +   A  IA+VGF++ IS+ K  
Sbjct: 302 GISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTL 361

Query: 367 ALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFI 426
           A +HGY+VD NQEL+ALGL N IG +FQ F +SCS+SRSLVQE TGG +Q+AG ++SL I
Sbjct: 362 ANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMI 421

Query: 427 LLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATIL 486
           LL+I+  G LF  LP+AVL+AI+IVNLKGM  Q SD+   W+ ++ +L IWL TF +++ 
Sbjct: 422 LLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLF 481

Query: 487 LNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSS 546
           L LD GL+ AVI +LL V+ RTQ P Y VLG++P+TD+Y D+  Y E KE+ G+K+F+ +
Sbjct: 482 LGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQIN 541

Query: 547 ATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKG 606
           A +Y+AN++ YS+ALK++ GV+   ++  ++K ++K                        
Sbjct: 542 APIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKY----------------------- 578

Query: 607 ASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDS---------KAPDGST 657
                      +++ + N+ +  +++  +    EDAT   +ED          K+     
Sbjct: 579 ----------AKEVGNANMANATVVKADAEVDGEDATKPEEEDGEVKYPPIVIKSTFPEE 628

Query: 658 LKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAAC 708
           ++    P  + H++ILD   ++F+D+V +K+L  I  ++ ++ + VY+A C
Sbjct: 629 MQRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGC 679


>gi|16418413 solute carrier family 26, member 9 isoform a [Homo
           sapiens]
          Length = 791

 Score =  504 bits (1298), Expect = e-142
 Identities = 265/713 (37%), Positives = 433/713 (60%), Gaps = 14/713 (1%)

Query: 51  PRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLA 110
           P   + R   +CS A+  A++   LPVL WLP+Y ++D+++ DLL GLS   +Q+PQG+A
Sbjct: 32  PVGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMA 91

Query: 111 YALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQ------ 164
           +ALLA LP V GLYSSF+P+  YF  G    +  GTFAV+S++VG++   LAP+      
Sbjct: 92  FALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVF 151

Query: 165 --ALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAA 222
             A N+S ++  A +A R+ V++TL+ L  + Q+GLG + FGFV  YLSE  +RG+ TAA
Sbjct: 152 NNATNESYVDTAAMEAERLHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAA 211

Query: 223 AVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKL 282
            +Q+ +S LKY+FGL + S++GP S+++T +++C  LP + + +++ A ++G  LV+VK 
Sbjct: 212 GLQILISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKE 271

Query: 283 LNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFS 342
           LN +   ++  PIP E++ ++ AT IS G  +  ++ + +VG I  G   PV+P    + 
Sbjct: 272 LNARYMHKIRFPIPTEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWK 331

Query: 343 KLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSM 402
            ++G+AF++A+V + I +++G+  A +HGY VDSNQE++ALG SN  G  F+   + C++
Sbjct: 332 DMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCAL 391

Query: 403 SRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSD 462
           S +L  +  GG SQVA    SL +++ ++ LG   + LPK+VL A+I VNLK  L+QL+D
Sbjct: 392 SVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTD 451

Query: 463 MRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDT 522
              LW+ ++ D  IW+V+F ++  L+L  G+ V V FS+L+VV +TQ  +   L QV DT
Sbjct: 452 PYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDT 511

Query: 523 DIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKK 582
           DIY +   Y+ A++++G+K+    + +YFAN+E +   +  + G+D   ++  K+K LKK
Sbjct: 512 DIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLKK 571

Query: 583 QEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVS----SGDK 638
           QE+ +++  Q+   L  +  +     +  +   +     +NN        VS    S D 
Sbjct: 572 QEKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQTPANGTSVSYITFSPDS 631

Query: 639 MEDATANGQEDSKAP-DGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFR 697
              A +     ++AP + S + A   P   FH+LILD+  +SFVD + +K+L  +   + 
Sbjct: 632 SSPAQSEPPASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYG 691

Query: 698 EIEVEVYMAACHSPVVSQLEAGHFF-DASITKKHLFASVHDAVTFALQHPRPV 749
           +I V+V++   H+ V + +  G  F D S+  KH+F S+HDAV FA  + R V
Sbjct: 692 KIGVKVFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSIHDAVLFAQANARDV 744


>gi|217272867 solute carrier family 26, member 9 isoform b [Homo
           sapiens]
          Length = 887

 Score =  504 bits (1298), Expect = e-142
 Identities = 265/713 (37%), Positives = 433/713 (60%), Gaps = 14/713 (1%)

Query: 51  PRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLA 110
           P   + R   +CS A+  A++   LPVL WLP+Y ++D+++ DLL GLS   +Q+PQG+A
Sbjct: 32  PVGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMA 91

Query: 111 YALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQ------ 164
           +ALLA LP V GLYSSF+P+  YF  G    +  GTFAV+S++VG++   LAP+      
Sbjct: 92  FALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVF 151

Query: 165 --ALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAA 222
             A N+S ++  A +A R+ V++TL+ L  + Q+GLG + FGFV  YLSE  +RG+ TAA
Sbjct: 152 NNATNESYVDTAAMEAERLHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAA 211

Query: 223 AVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKL 282
            +Q+ +S LKY+FGL + S++GP S+++T +++C  LP + + +++ A ++G  LV+VK 
Sbjct: 212 GLQILISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKE 271

Query: 283 LNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFS 342
           LN +   ++  PIP E++ ++ AT IS G  +  ++ + +VG I  G   PV+P    + 
Sbjct: 272 LNARYMHKIRFPIPTEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWK 331

Query: 343 KLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSM 402
            ++G+AF++A+V + I +++G+  A +HGY VDSNQE++ALG SN  G  F+   + C++
Sbjct: 332 DMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCAL 391

Query: 403 SRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSD 462
           S +L  +  GG SQVA    SL +++ ++ LG   + LPK+VL A+I VNLK  L+QL+D
Sbjct: 392 SVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTD 451

Query: 463 MRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDT 522
              LW+ ++ D  IW+V+F ++  L+L  G+ V V FS+L+VV +TQ  +   L QV DT
Sbjct: 452 PYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDT 511

Query: 523 DIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKK 582
           DIY +   Y+ A++++G+K+    + +YFAN+E +   +  + G+D   ++  K+K LKK
Sbjct: 512 DIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLKK 571

Query: 583 QEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVS----SGDK 638
           QE+ +++  Q+   L  +  +     +  +   +     +NN        VS    S D 
Sbjct: 572 QEKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQTPANGTSVSYITFSPDS 631

Query: 639 MEDATANGQEDSKAP-DGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFR 697
              A +     ++AP + S + A   P   FH+LILD+  +SFVD + +K+L  +   + 
Sbjct: 632 SSPAQSEPPASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYG 691

Query: 698 EIEVEVYMAACHSPVVSQLEAGHFF-DASITKKHLFASVHDAVTFALQHPRPV 749
           +I V+V++   H+ V + +  G  F D S+  KH+F S+HDAV FA  + R V
Sbjct: 692 KIGVKVFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSIHDAVLFAQANARDV 744


>gi|4557535 solute carrier family 26, member 3 [Homo sapiens]
          Length = 764

 Score =  499 bits (1286), Expect = e-141
 Identities = 275/731 (37%), Positives = 430/731 (58%), Gaps = 34/731 (4%)

Query: 29  YHMERPLLNQEHLEE----LGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRY 84
           Y + RP+ +    EE     GR       H  +    CS  +A  ++L   P+  WLP Y
Sbjct: 9   YIVARPVYSTNAFEENHKKTGRHHKTFLDHL-KVCCSCSPQKAKRIVLSLFPIASWLPAY 67

Query: 85  PVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISV 144
            +++WLL D++SG+S  I+ + QGLA+ALL  +PPV+GLY+SF+P  IY  FGTSRHISV
Sbjct: 68  RLKEWLLSDIVSGISTGIVAVLQGLAFALLVDIPPVYGLYASFFPAIIYLFFGTSRHISV 127

Query: 145 GTFAVMSVMVGSVTESLAPQALND----------SMINETARDAARVQVASTLSVLV--G 192
           G F ++S+MVG        +A+ D          +  N +  D  RV+VA+  SV V  G
Sbjct: 128 GPFPILSMMVGLAVSGAVSKAVPDRNATTLGLPNNSNNSSLLDDERVRVAAAASVTVLSG 187

Query: 193 LFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTV 252
           + Q+  G++  GFVV YLSE L+ G+TTAAAV V VSQLK++F L + SH+ P+S+   +
Sbjct: 188 IIQLAFGILRIGFVVIYLSESLISGFTTAAAVHVLVSQLKFIFQLTVPSHTDPVSIFKVL 247

Query: 253 LEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGM 312
             V  ++ ++ +  +VTA +  +V+ +VK +N + + +LP+PIP E +  + A G+SYG 
Sbjct: 248 YSVFSQIEKTNIADLVTALIVLLVVSIVKEINQRFKDKLPVPIPIEFIMTVIAAGVSYGC 307

Query: 313 GLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGY 372
             K+RF+V VVG++  G  PP+ P+ + F   VG  F IA+V FA+A S+  +++L++ Y
Sbjct: 308 DFKNRFKVAVVGDMNPGFQPPITPDVETFQNTVGDCFGIAMVAFAVAFSVASVYSLKYDY 367

Query: 373 RVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVK 432
            +D NQEL+ALGL N++ G+F+ F  S ++SRS VQESTGG +Q+AG I ++ +L++++ 
Sbjct: 368 PLDGNQELIALGLGNIVCGVFRGFAGSTALSRSAVQESTGGKTQIAGLIGAIIVLIVVLA 427

Query: 433 LGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLG 492
           +G L   L K+VLAA+ + NLKGML Q +++  LW+ ++ D LIW++TF  TI+L L LG
Sbjct: 428 IGFLLAPLQKSVLAALALGNLKGMLMQFAEIGRLWRKDKYDCLIWIMTFIFTIVLGLGLG 487

Query: 493 LVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFA 552
           L  +V F LL +V RTQ P  S L  +  T+IY++  +Y +  E  GVK+FR  + +YFA
Sbjct: 488 LAASVAFQLLTIVFRTQFPKCSTLANIGRTNIYKNKKDYYDMYEPEGVKIFRCPSPIYFA 547

Query: 553 NAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSIN 612
           N  F+   L    G     ++ ++ K L+     K+++LQK+  L+    +PKG   +++
Sbjct: 548 NIGFFRRKLIDAVGFSPLRILRKRNKALR-----KIRKLQKQGLLQ---VTPKGFICTVD 599

Query: 613 VNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLI 672
                ++   NN  +     +++ D       N        D   L  + +P+   HSLI
Sbjct: 600 TIKDSDEELDNNQIEVLDQPINTTDLPFHIDWN--------DDLPLN-IEVPKISLHSLI 650

Query: 673 LDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLF 732
           LD  A+SF+D   ++ LK+I  +F  I+V+VY+       + +L    FFD  +     F
Sbjct: 651 LDFSAVSFLDVSSVRGLKSILQEFIRIKVDVYIVGTDDDFIEKLNRYEFFDGEVKSSIFF 710

Query: 733 ASVHDAVTFAL 743
            ++HDAV   L
Sbjct: 711 LTIHDAVLHIL 721


>gi|45827802 prestin isoform c [Homo sapiens]
          Length = 516

 Score =  450 bits (1158), Expect = e-126
 Identities = 236/506 (46%), Positives = 334/506 (66%), Gaps = 15/506 (2%)

Query: 15  LLSATQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWRTWLQCSRARAYALL 71
           +L+ATQ        Y++ERP+ +   L+E L      P +   + +    C+  +   ++
Sbjct: 9   ILAATQR-------YYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNII 61

Query: 72  LQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVF 131
              LP+  WLP Y  ++++LGDL+SG+S  ++QLPQGLA+A+LA +PP+FGLYSSFYPV 
Sbjct: 62  YMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVI 121

Query: 132 IYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET----ARDAARVQVAST 186
           +Y   GTSRHIS+G FAV+S+M+G V   L P  +     +N T    ARDA RV+VA +
Sbjct: 122 MYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMS 181

Query: 187 LSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPL 246
           +++L G+ Q  LG+  FGFV  YL+EPLVRG+TTAAAV VF S LKY+FG+    +SG  
Sbjct: 182 VTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIF 241

Query: 247 SLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGAT 306
           S++Y+ + V   +    V ++    +   +L+  K  N++ +++LP PIP E   ++  T
Sbjct: 242 SVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGT 301

Query: 307 GISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIF 366
           GIS G  LK  + VDVVG +P GL+PP  P+T LF  +   A  IA+VGF++ IS+ K  
Sbjct: 302 GISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTL 361

Query: 367 ALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFI 426
           A +HGY+VD NQEL+ALGL N IG +FQ F +SCS+SRSLVQE TGG +Q+AG ++SL I
Sbjct: 362 ANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMI 421

Query: 427 LLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATIL 486
           LL+I+  G LF  LP+AVL+AI+IVNLKGM  Q SD+   W+ ++ +L IWL TF +++ 
Sbjct: 422 LLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLF 481

Query: 487 LNLDLGLVVAVIFSLLLVVVRTQMPH 512
           L LD GL+ AVI +LL V+ RTQ  H
Sbjct: 482 LGLDYGLITAVIIALLTVIYRTQSFH 507


>gi|47131207 solute carrier family 26, member 1 isoform a [Homo
           sapiens]
          Length = 701

 Score =  405 bits (1042), Expect = e-113
 Identities = 240/711 (33%), Positives = 383/711 (53%), Gaps = 82/711 (11%)

Query: 57  RTWLQCSRAR--AYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALL 114
           R W  CS +     AL+   LP   WL +Y  R++L GD++SGL + I+ +PQ +AY+LL
Sbjct: 34  RLWCSCSCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLL 93

Query: 115 AGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTE-------------SL 161
           AGL P++ LY+SF+   IYFL GTSRH+SVG F+++ +MVG V +              L
Sbjct: 94  AGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGL 153

Query: 162 APQALNDSMINETA------RDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLV 215
            P A N S +N +A      RD   ++VA+ L+++ GL+QV +G++  GFV  YLS+PL+
Sbjct: 154 QPGA-NSSTLNGSAAMLDCGRDCYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLL 212

Query: 216 RGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGV 275
            G+   A+V +  SQLK++ G+ +  H GP  ++ T L +     Q+ V  VVT+ V   
Sbjct: 213 DGFAMGASVTILTSQLKHLLGVRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVTSTVCLA 272

Query: 276 VLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVA 335
           VL+  K L+D+ + +L +P+P ELL ++ AT +S+   L  RF   V G+IP G +PP  
Sbjct: 273 VLLAAKELSDRYRHRLRVPLPTELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMPPQV 332

Query: 336 PNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQC 395
           P  +L  ++   A  +A+V  A +ISL ++FA  HGY V +NQEL+A+G  N++     C
Sbjct: 333 PEPRLMQRVALDAVALALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHC 392

Query: 396 FPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKG 455
           F  S ++++SLV+ +TG  +Q++  +S+  +LL+++ L  LFHDL ++VLA +I+V+L+G
Sbjct: 393 FATSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRG 452

Query: 456 MLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSV 515
            LR++ D+  LW+ + AD L+W  T    +L++ + GL+  VI SLL +  RTQ P  ++
Sbjct: 453 ALRKVWDLPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTAL 512

Query: 516 LGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQ 575
           L ++ DT  Y D  E+       GV+VFR    +Y+AN +F+  +L    G+D   + ++
Sbjct: 513 LARIGDTAFYEDATEFEGLVPEPGVRVFRFGGPLYYANKDFFLQSLYSLTGLDAGCMAAR 572

Query: 576 KKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSS 635
                                 RK+  S  G                             
Sbjct: 573 ----------------------RKEGGSETGVG--------------------------- 583

Query: 636 GDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHD 695
               E   A G++       ST  AL      FH++++D   L F+D   + +L+++  D
Sbjct: 584 ----EGGPAQGEDLGPV---STRAALVPAAAGFHTVVIDCAPLLFLDAAGVSTLQDLRRD 636

Query: 696 FREIEVEVYMAACHSPVVSQLEAGHFFDA----SITKKHLFASVHDAVTFA 742
           +  + + + +A C  PV   L  G F       +  ++ LF SVHDAV  A
Sbjct: 637 YGALGISLLLACCSPPVRDILSRGGFLGEGPGDTAEEEQLFLSVHDAVQTA 687


>gi|20336272 solute carrier family 26, member 1 isoform a [Homo
           sapiens]
          Length = 701

 Score =  405 bits (1042), Expect = e-113
 Identities = 240/711 (33%), Positives = 383/711 (53%), Gaps = 82/711 (11%)

Query: 57  RTWLQCSRAR--AYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALL 114
           R W  CS +     AL+   LP   WL +Y  R++L GD++SGL + I+ +PQ +AY+LL
Sbjct: 34  RLWCSCSCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLL 93

Query: 115 AGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTE-------------SL 161
           AGL P++ LY+SF+   IYFL GTSRH+SVG F+++ +MVG V +              L
Sbjct: 94  AGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGL 153

Query: 162 APQALNDSMINETA------RDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLV 215
            P A N S +N +A      RD   ++VA+ L+++ GL+QV +G++  GFV  YLS+PL+
Sbjct: 154 QPGA-NSSTLNGSAAMLDCGRDCYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLL 212

Query: 216 RGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGV 275
            G+   A+V +  SQLK++ G+ +  H GP  ++ T L +     Q+ V  VVT+ V   
Sbjct: 213 DGFAMGASVTILTSQLKHLLGVRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVTSTVCLA 272

Query: 276 VLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVA 335
           VL+  K L+D+ + +L +P+P ELL ++ AT +S+   L  RF   V G+IP G +PP  
Sbjct: 273 VLLAAKELSDRYRHRLRVPLPTELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMPPQV 332

Query: 336 PNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQC 395
           P  +L  ++   A  +A+V  A +ISL ++FA  HGY V +NQEL+A+G  N++     C
Sbjct: 333 PEPRLMQRVALDAVALALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHC 392

Query: 396 FPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKG 455
           F  S ++++SLV+ +TG  +Q++  +S+  +LL+++ L  LFHDL ++VLA +I+V+L+G
Sbjct: 393 FATSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRG 452

Query: 456 MLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSV 515
            LR++ D+  LW+ + AD L+W  T    +L++ + GL+  VI SLL +  RTQ P  ++
Sbjct: 453 ALRKVWDLPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTAL 512

Query: 516 LGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQ 575
           L ++ DT  Y D  E+       GV+VFR    +Y+AN +F+  +L    G+D   + ++
Sbjct: 513 LARIGDTAFYEDATEFEGLVPEPGVRVFRFGGPLYYANKDFFLQSLYSLTGLDAGCMAAR 572

Query: 576 KKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSS 635
                                 RK+  S  G                             
Sbjct: 573 ----------------------RKEGGSETGVG--------------------------- 583

Query: 636 GDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHD 695
               E   A G++       ST  AL      FH++++D   L F+D   + +L+++  D
Sbjct: 584 ----EGGPAQGEDLGPV---STRAALVPAAAGFHTVVIDCAPLLFLDAAGVSTLQDLRRD 636

Query: 696 FREIEVEVYMAACHSPVVSQLEAGHFFDA----SITKKHLFASVHDAVTFA 742
           +  + + + +A C  PV   L  G F       +  ++ LF SVHDAV  A
Sbjct: 637 YGALGISLLLACCSPPVRDILSRGGFLGEGPGDTAEEEQLFLSVHDAVQTA 687


>gi|100913030 solute carrier family 26 member 2 [Homo sapiens]
          Length = 739

 Score =  404 bits (1037), Expect = e-112
 Identities = 229/703 (32%), Positives = 383/703 (54%), Gaps = 83/703 (11%)

Query: 61  QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV 120
           QCS A+A  ++L  LPVL WLP+Y ++  +LGD++SGL V I+ +PQ +AY+LLAG  PV
Sbjct: 79  QCSPAKAKNMILGFLPVLQWLPKYDLKKNILGDVMSGLIVGILLVPQSIAYSLLAGQEPV 138

Query: 121 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTE---------------SLAPQA 165
           +GLY+SF+   IYFL GTSRHISVG F V+ +M+G   +               SL   +
Sbjct: 139 YGLYTSFFASIIYFLLGTSRHISVGIFGVLCLMIGETVDRELQKAGYDNAHSAPSLGMVS 198

Query: 166 LNDSMINETA-----RDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTT 220
              +++N T+     +    + V ST++ + G++QV +G    GFV  YLS+ L+ G+ T
Sbjct: 199 NGSTLLNHTSDRICDKSCYAIMVGSTVTFIAGVYQVAMGFFQVGFVSVYLSDALLSGFVT 258

Query: 221 AAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVV 280
            A+  +  SQ KY+ GL+L   +G  SLI T + V   + ++ +  ++T+ +  +VL+  
Sbjct: 259 GASFTILTSQAKYLLGLNLPRTNGVGSLITTWIHVFRNIHKTNLCDLITSLLCLLVLLPT 318

Query: 281 KLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQL 340
           K LN+  + +L  PIP EL+ ++ AT  S+   L   +   + G+IP G +PP  P   L
Sbjct: 319 KELNEHFKSKLKAPIPIELVVVVAATLASHFGKLHENYNSSIAGHIPTGFMPPKVPEWNL 378

Query: 341 FSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSC 400
              +   A  I+++GFAI +SL ++FA +HGY V +NQE+ A+G  N+I   F CF  S 
Sbjct: 379 IPSVAVDAIAISIIGFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCFTTSA 438

Query: 401 SMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQL 460
           +++++LV+ESTG ++Q++G +++L +LL+++ +  LF+ L K+VL  I IVNL+G LR+ 
Sbjct: 439 ALAKTLVKESTGCHTQLSGVVTALVLLLVLLVIAPLFYSLQKSVLGVITIVNLRGALRKF 498

Query: 461 SDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVP 520
            D+  +W  +R D +IW VT  ++ LL+ ++GL+V V FS+  V++RTQ P  S+LG V 
Sbjct: 499 RDLPKMWSISRMDTVIWFVTMLSSALLSTEIGLLVGVCFSIFCVILRTQKPKSSLLGLVE 558

Query: 521 DTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLL 580
           +++++  V+ Y   +   G+K+FR  A +Y+ N E +  AL ++    +   ++ KK   
Sbjct: 559 ESEVFESVSAYKNLQIKPGIKIFRFVAPLYYINKECFKSALYKQTVNPILIKVAWKK--- 615

Query: 581 KKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNN-VEDCKMMQVSSGDKM 639
                        + K++++  +  G    ++V  S + +  +  V DC  +Q       
Sbjct: 616 -----------AAKRKIKEKVVTLGGIQDEMSVQLSHDPLELHTIVIDCSAIQ------- 657

Query: 640 EDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREI 699
                                                   F+DT  + +LK +  D+  I
Sbjct: 658 ----------------------------------------FLDTAGIHTLKEVRRDYEAI 677

Query: 700 EVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHDAVTFA 742
            ++V +A C+  V   L  G +      +  LF SV++A+ FA
Sbjct: 678 GIQVLLAQCNPTVRDSLTNGEYCKKE-EENLLFYSVYEAMAFA 719


>gi|16418457 solute carrier family 26, member 8 isoform a [Homo
           sapiens]
          Length = 970

 Score =  373 bits (957), Expect = e-103
 Identities = 241/787 (30%), Positives = 413/787 (52%), Gaps = 76/787 (9%)

Query: 21  AMDLRRRDYHMERPLLNQEHLEELGRWGSAP---RTHQWRTWLQCSRARAYALLLQHLPV 77
           A D++R  Y+ E     QEH  +    G+      T +     +CS  R    +L   P 
Sbjct: 22  AYDVKREVYNEET--FQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCVLTIFPF 79

Query: 78  LVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAG--LPPVFGLYSSFYPVFIYFL 135
           L W+  Y ++DWLLGDLL+G+SV ++Q+PQGL  +LLA   +PP+   Y++F    IY +
Sbjct: 80  LEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVI 139

Query: 136 FGTSRHISVGTFAVMSVMVGSVTESLAP----QALNDSMI-NETARDA------ARVQVA 184
           FG+   +S+G+F ++S ++ +V + ++P    Q +  S + NE +  +        + V 
Sbjct: 140 FGSCHQMSIGSFFLVSALLINVLK-VSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVV 198

Query: 185 STLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSG 244
           +T + L G+ Q+ +G++  GF+ TYL E  +  Y  A A+ + +SQL ++FG+ +S H+G
Sbjct: 199 ATTTFLTGIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHIMLSQLTFIFGIMISFHAG 258

Query: 245 PLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIG 304
           P+S  Y ++  C  LP++   +++      V L + K +     Q  P+  P EL  +IG
Sbjct: 259 PISFFYDIINYCVALPKANSTSILVFLTVVVALRINKCIRISFNQY-PIEFPMELFLIIG 317

Query: 305 ATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGK 364
            T I+  + +       ++  IP   + PV P+  L  K++  AF++++V   + I LGK
Sbjct: 318 FTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGK 377

Query: 365 IFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSL 424
             A  H Y V+SNQ+L+A+GL N++   F+    + +++R+++Q+ +GG  Q A  + + 
Sbjct: 378 KIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAG 437

Query: 425 FILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTAT 484
            +LL++VK+G  F+ LP AVLA II+ N+   L  +S++ SLW+ ++ D  +W++TF+++
Sbjct: 438 VMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSS 497

Query: 485 ILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFR 544
           I L LD+GL+++V+ +  +  VR+      +LGQ+P+T+IYR + +Y E   + GVK+F+
Sbjct: 498 IFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQ 557

Query: 545 SSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKL-----KQLQKEEKLR- 598
             +++ F N  +    LK +   +VD +    K  LK++E   L       LQ  +  R 
Sbjct: 558 CCSSITFVNVYY----LKHKLLKEVDMV----KVPLKEEEIFSLFNSSDTNLQGGKICRC 609

Query: 599 -------------------KQAASPKGASVSINVNTSLEDMRSNNV--EDCKMMQVSS-G 636
                              +    P+ +S+++   +  E M ++    ED     VSS  
Sbjct: 610 FCNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVS 669

Query: 637 DKMEDATANGQEDSKAPDGSTLKAL-GLPQ-------------------PDFHSLILDLG 676
            K +       E+   P+ S+  +  GLP                    P  H++ILD  
Sbjct: 670 QKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFS 729

Query: 677 ALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVH 736
            + +VD+  L  L+ I + F+   + + +A CHS +V   E   FFDA ITK  LF SVH
Sbjct: 730 MVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVH 789

Query: 737 DAVTFAL 743
           DAV FAL
Sbjct: 790 DAVLFAL 796


>gi|16306483 solute carrier family 26, member 7 isoform a [Homo
           sapiens]
          Length = 656

 Score =  307 bits (787), Expect = 2e-83
 Identities = 164/497 (32%), Positives = 291/497 (58%), Gaps = 10/497 (2%)

Query: 73  QHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFI 132
           + LP+L W P Y +++ LL D +SG+ +A+ Q+ QGLA+A+L+ + PVFGLY S +P  I
Sbjct: 30  RRLPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAII 89

Query: 133 YFLFGTSRHISVGTFAVMSVMVGSVTESLAPQAL-------NDSMINETARDAARVQVAS 185
           Y +FG   H++ GTFA+ S++  +  E + PQ +       N S++  +  +  R+ VA+
Sbjct: 90  YAIFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAA 149

Query: 186 TLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGP 245
            +S L G+ QV + ++  G     ++EP++   TT AA  V  SQ+KY+ G+ +   SGP
Sbjct: 150 AVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGP 209

Query: 246 LSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGA 305
           L   Y    V   +   ++  ++ + ++ VVLV+VK LN++ ++++ + +P +L+ +I A
Sbjct: 210 LGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAA 269

Query: 306 TGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKI 365
           +   Y   +++ + ++VVG+IP G+  P AP   + S ++  AF +A+VG+  +++L + 
Sbjct: 270 SFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQG 329

Query: 366 FALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLF 425
            A +  Y +D NQE +A GLSN++   F C P + +M R+    STG  +QVA  IS +F
Sbjct: 330 SAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIF 389

Query: 426 ILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATI 485
           +L++I  +G L + LP  VLA+II+V LKGML Q  D++  W  ++ D  IW+ T+  TI
Sbjct: 390 VLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTI 449

Query: 486 LLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRS 545
               ++GL+  V+ ++ +V+ R   P    +      ++   V    +++ ++ VK+   
Sbjct: 450 CFAANVGLLFGVVCTIAIVIGR--FPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKIISI 507

Query: 546 SATVYFANA-EFYSDAL 561
           +  + F NA +FY+D +
Sbjct: 508 NNPLVFLNAKKFYTDLM 524


>gi|20336282 solute carrier family 26, member 7 isoform b [Homo
           sapiens]
          Length = 663

 Score =  307 bits (787), Expect = 2e-83
 Identities = 164/497 (32%), Positives = 291/497 (58%), Gaps = 10/497 (2%)

Query: 73  QHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFI 132
           + LP+L W P Y +++ LL D +SG+ +A+ Q+ QGLA+A+L+ + PVFGLY S +P  I
Sbjct: 30  RRLPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAII 89

Query: 133 YFLFGTSRHISVGTFAVMSVMVGSVTESLAPQAL-------NDSMINETARDAARVQVAS 185
           Y +FG   H++ GTFA+ S++  +  E + PQ +       N S++  +  +  R+ VA+
Sbjct: 90  YAIFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAA 149

Query: 186 TLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGP 245
            +S L G+ QV + ++  G     ++EP++   TT AA  V  SQ+KY+ G+ +   SGP
Sbjct: 150 AVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGP 209

Query: 246 LSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGA 305
           L   Y    V   +   ++  ++ + ++ VVLV+VK LN++ ++++ + +P +L+ +I A
Sbjct: 210 LGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAA 269

Query: 306 TGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKI 365
           +   Y   +++ + ++VVG+IP G+  P AP   + S ++  AF +A+VG+  +++L + 
Sbjct: 270 SFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQG 329

Query: 366 FALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLF 425
            A +  Y +D NQE +A GLSN++   F C P + +M R+    STG  +QVA  IS +F
Sbjct: 330 SAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIF 389

Query: 426 ILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATI 485
           +L++I  +G L + LP  VLA+II+V LKGML Q  D++  W  ++ D  IW+ T+  TI
Sbjct: 390 VLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTI 449

Query: 486 LLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRS 545
               ++GL+  V+ ++ +V+ R   P    +      ++   V    +++ ++ VK+   
Sbjct: 450 CFAANVGLLFGVVCTIAIVIGR--FPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKIISI 507

Query: 546 SATVYFANA-EFYSDAL 561
           +  + F NA +FY+D +
Sbjct: 508 NNPLVFLNAKKFYTDLM 524


>gi|65506789 solute carrier family 26, member 10 [Homo sapiens]
          Length = 563

 Score =  279 bits (713), Expect = 8e-75
 Identities = 147/371 (39%), Positives = 230/371 (61%), Gaps = 2/371 (0%)

Query: 108 GLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQAL- 166
           G+A+ALLA +PPVFGLY+SF+PV IY L GT RH+S GTFA++S+M GS  E L P+ L 
Sbjct: 41  GMAFALLASVPPVFGLYTSFFPVLIYSLLGTGRHLSTGTFAILSLMTGSAVERLVPEPLV 100

Query: 167 -NDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQ 225
            N S I +   DA RV VA+ ++   G   +G+ ++  G + T+LSEP+V+  T+ AA+ 
Sbjct: 101 GNLSGIEKEQLDAQRVGVAAAVAFGSGALMLGMFVLQLGVLSTFLSEPVVKALTSGAALH 160

Query: 226 VFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLND 285
           V +SQL  + GL L    G  SL  T+  +   LP+S    +  +A++  +LV VK LN 
Sbjct: 161 VLLSQLPSLLGLSLPRQIGCFSLFKTLASLLTALPRSSPAELTISALSLALLVPVKELNV 220

Query: 286 KLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLV 345
           + + +LP PIPGE++ ++ A+ + +   +  R++V +VG +P G   P+ PN     +++
Sbjct: 221 RFRDRLPTPIPGEVVLVLLASVLCFTSSVDTRYQVQIVGLLPGGFPQPLLPNLAELPRIL 280

Query: 346 GSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRS 405
             +  IA+V FA++ SL  I A ++ Y +DSNQE +A G SNLI  +F CFP S +++ +
Sbjct: 281 ADSLPIALVSFAVSASLASIHADKYSYTIDSNQEFLAHGASNLISSLFSCFPNSATLATT 340

Query: 406 LVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRS 465
            +    GG +Q+AG  S   +L +++ LG  F+ LPKAVLA I I +++ +  Q+ ++  
Sbjct: 341 NLLVDAGGKTQLAGLFSCTVVLSVLLWLGPFFYYLPKAVLACINISSMRQVFCQMQELPQ 400

Query: 466 LWKANRADLLI 476
           LW  +R D L+
Sbjct: 401 LWHISRVDFLL 411


>gi|217272870 solute carrier family 26, member 9 isoform c [Homo
           sapiens]
          Length = 459

 Score =  259 bits (663), Expect = 5e-69
 Identities = 144/412 (34%), Positives = 240/412 (58%), Gaps = 6/412 (1%)

Query: 344 LVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMS 403
           ++G+AF++A+V + I +++G+  A +HGY VDSNQE++ALG SN  G  F+   + C++S
Sbjct: 1   MIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALS 60

Query: 404 RSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDM 463
            +L  +  GG SQVA    SL +++ ++ LG   + LPK+VL A+I VNLK  L+QL+D 
Sbjct: 61  VTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDP 120

Query: 464 RSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTD 523
             LW+ ++ D  IW+V+F ++  L+L  G+ V V FS+L+VV +TQ  +   L QV DTD
Sbjct: 121 YYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTD 180

Query: 524 IYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQ 583
           IY +   Y+ A++++G+K+    + +YFAN+E +   +  + G+D   ++  K+K LKKQ
Sbjct: 181 IYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQ 240

Query: 584 EQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVS----SGDKM 639
           E+ +++  Q+   L  +  +     +  +   +     +NN        VS    S D  
Sbjct: 241 EKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQTPANGTSVSYITFSPDSS 300

Query: 640 EDATANGQEDSKAP-DGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFRE 698
             A +     ++AP + S + A   P   FH+LILD+  +SFVD + +K+L  +   + +
Sbjct: 301 SPAQSEPPASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYGK 360

Query: 699 IEVEVYMAACHSPVVSQLEAGHFF-DASITKKHLFASVHDAVTFALQHPRPV 749
           I V+V++   H+ V + +  G  F D S+  KH+F S+HDAV FA  + R V
Sbjct: 361 IGVKVFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSIHDAVLFAQANARDV 412


>gi|45827804 prestin isoform d [Homo sapiens]
          Length = 335

 Score =  248 bits (634), Expect = 1e-65
 Identities = 136/323 (42%), Positives = 201/323 (62%), Gaps = 15/323 (4%)

Query: 15  LLSATQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWRTWLQCSRARAYALL 71
           +L+ATQ        Y++ERP+ +   L+E L      P +   + +    C+  +   ++
Sbjct: 9   ILAATQR-------YYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNII 61

Query: 72  LQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVF 131
              LP+  WLP Y  ++++LGDL+SG+S  ++QLPQGLA+A+LA +PP+FGLYSSFYPV 
Sbjct: 62  YMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVI 121

Query: 132 IYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET----ARDAARVQVAST 186
           +Y   GTSRHIS+G FAV+S+M+G V   L P  +     +N T    ARDA RV+VA +
Sbjct: 122 MYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMS 181

Query: 187 LSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPL 246
           +++L G+ Q  LG+  FGFV  YL+EPLVRG+TTAAAV VF S LKY+FG+    +SG  
Sbjct: 182 VTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIF 241

Query: 247 SLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGAT 306
           S++Y+ + V   +    V ++    +   +L+  K  N++ +++LP PIP E   ++  T
Sbjct: 242 SVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGT 301

Query: 307 GISYGMGLKHRFEVDVVGNIPAG 329
           GIS G  LK  + VDVVG +P G
Sbjct: 302 GISAGFNLKESYNVDVVGTLPLG 324


>gi|20336285 solute carrier family 26, member 8 isoform b [Homo
           sapiens]
          Length = 865

 Score =  234 bits (598), Expect = 2e-61
 Identities = 172/606 (28%), Positives = 290/606 (47%), Gaps = 65/606 (10%)

Query: 189 VLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSL 248
           + VGL QV  GL     +   L  PL   Y    +  ++V     +FG       G   L
Sbjct: 100 ISVGLVQVPQGLT-LSLLARQLIPPLNIAYAAFCSSVIYV-----IFGSCHQMSIGSFFL 153

Query: 249 IYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLL---NDKLQQQLPMPIPGELLTLIGA 305
           +  +L    K+     G +V  +           L   N  L           ++ +IG 
Sbjct: 154 VSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQIIGF 213

Query: 306 TGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKI 365
           T I+  + +       ++  IP   + PV P+  L  K++  AF++++V   + I LGK 
Sbjct: 214 TVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKK 273

Query: 366 FALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLF 425
            A  H Y V+SNQ+L+A+GL N++   F+    + +++R+++Q+ +GG  Q A  + +  
Sbjct: 274 IASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGV 333

Query: 426 ILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATI 485
           +LL++VK+G  F+ LP AVLA II+ N+   L  +S++ SLW+ ++ D  +W++TF+++I
Sbjct: 334 MLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSI 393

Query: 486 LLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRS 545
            L LD+GL+++V+ +  +  VR+      +LGQ+P+T+IYR + +Y E   + GVK+F+ 
Sbjct: 394 FLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQC 453

Query: 546 SATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKL-----KQLQKEEKLR-- 598
            +++ F N  +    LK +   +VD +    K  LK++E   L       LQ  +  R  
Sbjct: 454 CSSITFVNVYY----LKHKLLKEVDMV----KVPLKEEEIFSLFNSSDTNLQGGKICRCF 505

Query: 599 ------------------KQAASPKGASVSINVNTSLEDMRSNNV--EDCKMMQVSS-GD 637
                             +    P+ +S+++   +  E M ++    ED     VSS   
Sbjct: 506 CNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVSQ 565

Query: 638 KMEDATANGQEDSKAPDGSTLKAL-GLPQ-------------------PDFHSLILDLGA 677
           K +       E+   P+ S+  +  GLP                    P  H++ILD   
Sbjct: 566 KNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSM 625

Query: 678 LSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHD 737
           + +VD+  L  L+ I + F+   + + +A CHS +V   E   FFDA ITK  LF SVHD
Sbjct: 626 VHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVHD 685

Query: 738 AVTFAL 743
           AV FAL
Sbjct: 686 AVLFAL 691



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 50/142 (35%), Positives = 81/142 (57%), Gaps = 7/142 (4%)

Query: 21  AMDLRRRDYHMERPLLNQEHLEELGRWGSAP---RTHQWRTWLQCSRARAYALLLQHLPV 77
           A D++R  Y+ E     QEH  +    G+      T +     +CS  R    +L   P 
Sbjct: 22  AYDVKREVYNEET--FQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCMLTIFPF 79

Query: 78  LVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAG--LPPVFGLYSSFYPVFIYFL 135
           L W+  Y ++DWLLGDLL+G+SV ++Q+PQGL  +LLA   +PP+   Y++F    IY +
Sbjct: 80  LEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVI 139

Query: 136 FGTSRHISVGTFAVMSVMVGSV 157
           FG+   +S+G+F ++S ++ +V
Sbjct: 140 FGSCHQMSIGSFFLVSALLINV 161


>gi|85540447 solute carrier family 26, member 11 [Homo sapiens]
          Length = 606

 Score =  226 bits (576), Expect = 6e-59
 Identities = 149/474 (31%), Positives = 248/474 (52%), Gaps = 53/474 (11%)

Query: 69  ALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFY 128
           A L + LP+L WLP Y ++ WL  D ++GLSV +  +PQ LAYA +AGLPP +GLYS+F 
Sbjct: 28  AALQRRLPILAWLPSYSLQ-WLKMDFVAGLSVGLTAIPQALAYAEVAGLPPQYGLYSAFM 86

Query: 129 PVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLS 188
             F+YF  GTSR +++G  A+MS++V   T             +E A        A  L+
Sbjct: 87  GCFVYFFLGTSRDVTLGPTAIMSLLVSFYT------------FHEPA-------YAVLLA 127

Query: 189 VLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSL 248
            L G  Q+ +G++  GF++ ++S P+++G+T+AAAV +   Q+K + GL        L +
Sbjct: 128 FLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSAAAVTIGFGQIKNLLGLQNIPRPFFLQV 187

Query: 249 IYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL-------- 300
            +T L +     +++VG  V   V  ++L+V+KL+ D +    P   PG  L        
Sbjct: 188 YHTFLRIA----ETRVGDAVLGLVCMLLLLVLKLMRDHVPPVHPEMPPGVRLSRGLVWAA 243

Query: 301 -TLIGATGISYGMGLKHRFEV----------DVVGNIPAGLVPP----VAPNTQLFSKLV 345
            T   A  +S+   + + FEV          +    +P   +PP     A  T  F+++V
Sbjct: 244 TTARNALVVSFAALVAYSFEVTGYQPFILTGETAEGLPPVRIPPFSVTTANGTISFTEMV 303

Query: 346 ----GSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCS 401
                    + ++G   +I++ K FA ++ YR+D+NQEL+A+GL+N++G +   +PV+ S
Sbjct: 304 QDMGAGLAVVPLMGLLESIAVAKAFASQNNYRIDANQELLAIGLTNMLGSLVSSYPVTGS 363

Query: 402 MSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLS 461
             R+ V   +G  +   G ++ + +LL +  L  LF+ +PK+ LAA+II+ +   L    
Sbjct: 364 FGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALAAVIIMAV-APLFDTK 422

Query: 462 DMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSV 515
             R+LW+  R DLL   VTF       +  G++   + SLL+++     P   V
Sbjct: 423 IFRTLWRVKRLDLLPLCVTF-LLCFWEVQYGILAGALVSLLMLLHSAARPETKV 475


>gi|20336274 solute carrier family 26, member 1 isoform b [Homo
           sapiens]
          Length = 224

 Score =  115 bits (288), Expect = 2e-25
 Identities = 66/164 (40%), Positives = 97/164 (59%), Gaps = 22/164 (13%)

Query: 57  RTWLQCSRAR--AYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALL 114
           R W  CS +     AL+   LP   WL +Y  R++L GD++SGL + I+ +PQ +AY+LL
Sbjct: 34  RLWCSCSCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLL 93

Query: 115 AGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVT-------------ESL 161
           AGL P++ LY+SF+   IYFL GTSRH+SVG F+++ +MVG V              + L
Sbjct: 94  AGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGL 153

Query: 162 APQALNDSMINETA------RDAARVQVASTLSVLVGLFQVGLG 199
            P A N S +N +A      RD   ++VA+ L+++ GL+Q   G
Sbjct: 154 QPGA-NSSTLNGSAAMLDCGRDCYAIRVATALTLMTGLYQTSWG 196


>gi|116256458 hypothetical protein LOC121053 [Homo sapiens]
          Length = 185

 Score = 34.7 bits (78), Expect = 0.34
 Identities = 25/104 (24%), Positives = 49/104 (47%), Gaps = 11/104 (10%)

Query: 575 QKKKLLKKQEQLKLKQLQKEEKLRKQ-AASPKGA----------SVSINVNTSLEDMRSN 623
           ++  LL + +    +  +  EKLRK+ AA+P G           S  I ++ +L +M  +
Sbjct: 64  ERSPLLDQVQTFLPQMARANEKLRKEMAAAPPGRFNIENIDGPHSKVIQMDVALFEMNQS 123

Query: 624 NVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPD 667
           + ++    + SS D  E+++ +  ED   P   T+  + LP  +
Sbjct: 124 DSKEVDSSEESSQDSSENSSESEDEDDSIPSEVTIDNIKLPNSE 167


>gi|62422577 neurobeachin [Homo sapiens]
          Length = 2946

 Score = 32.7 bits (73), Expect = 1.3
 Identities = 27/81 (33%), Positives = 37/81 (45%), Gaps = 4/81 (4%)

Query: 166 LNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQ 225
           LNDS +  T        +   L   V + +  LG   F  V+ YL E   R + T A ++
Sbjct: 514 LNDSQVETTVCATLLAFLVELLKSSVAMQEQMLGGKGF-LVIGYLLEKSSRVHITRAVLE 572

Query: 226 VFVSQLKYVFGLHLSSHSGPL 246
            F+S  KY+ GL   SH  PL
Sbjct: 573 QFLSFAKYLDGL---SHGAPL 590


>gi|40068059 CBF1 interacting corepressor [Homo sapiens]
          Length = 450

 Score = 32.3 bits (72), Expect = 1.7
 Identities = 31/113 (27%), Positives = 52/113 (46%), Gaps = 22/113 (19%)

Query: 568 DVDFLIS----QKKKLLKKQEQLKLKQLQKEEKLRK---------------QAASPKGAS 608
           +V+FL S    QK+KLL+K ++L+ K+ +K+ K +K                ++S   +S
Sbjct: 209 EVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSS 268

Query: 609 VSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKAL 661
            S   + S  +  SNN E  K +Q     K    + +   DS+  D S  + L
Sbjct: 269 SSTETSESSSESESNNKE--KKIQ-RKKRKKNKCSGHNNSDSEEKDKSKKRKL 318


>gi|55749531 splicing factor 3B subunit 2 [Homo sapiens]
          Length = 895

 Score = 32.3 bits (72), Expect = 1.7
 Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 13/88 (14%)

Query: 580 LKKQEQLKLKQLQKEEKLRKQAASPKGASVS------INVNTSLEDMRSNNVEDCKMMQ- 632
           LK+  Q ++   Q+EE++   A S  G S S      ++V+   ++ +  N +  K  Q 
Sbjct: 279 LKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQR 338

Query: 633 ------VSSGDKMEDATANGQEDSKAPD 654
                  SSGD+ +D+T +   DS A D
Sbjct: 339 VRGVSSESSGDREKDSTRSRGSDSPAAD 366


>gi|157649069 ATPase, aminophospholipid transporter (APLT), class I,
           type 8A, member 1 isoform b [Homo sapiens]
          Length = 1149

 Score = 32.0 bits (71), Expect = 2.2
 Identities = 50/198 (25%), Positives = 90/198 (45%), Gaps = 19/198 (9%)

Query: 504 VVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEV--RGVKVFRSSA--TVYFANAEFYSD 559
           V+VRT      +  +  DT IY  +AE S+ KE+  + ++ F +    T+ FA AE    
Sbjct: 543 VIVRTPSGKLRLYCKGADTVIYDRLAETSKYKEITLKHLEQFATEGLRTLCFAVAEISES 602

Query: 560 ALKQRCGVDVDFLISQKKKLLKKQEQLKL--KQLQK------EEKLRKQAASP----KGA 607
             ++   V      S + +LLK +E  +L  K LQ       E+KL+ Q          A
Sbjct: 603 DFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKA 662

Query: 608 SVSINVNTSLEDMRSNNV-EDCKMMQVSSG-DKMEDATANGQEDSKAPDGSTLKALGLPQ 665
            + I + T  +   + N+   CK+++ + G   + + + +G  ++ +   +TL      +
Sbjct: 663 DIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSLDGTRETLSRHCTTLGDALRKE 722

Query: 666 PDFHSLILDLGALSFVDT 683
            DF +LI+D   L +  T
Sbjct: 723 NDF-ALIIDGKTLKYALT 739


>gi|17978471 ATPase, aminophospholipid transporter (APLT), class I,
           type 8A, member 1 isoform a [Homo sapiens]
          Length = 1164

 Score = 32.0 bits (71), Expect = 2.2
 Identities = 50/198 (25%), Positives = 90/198 (45%), Gaps = 19/198 (9%)

Query: 504 VVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEV--RGVKVFRSSA--TVYFANAEFYSD 559
           V+VRT      +  +  DT IY  +AE S+ KE+  + ++ F +    T+ FA AE    
Sbjct: 558 VIVRTPSGKLRLYCKGADTVIYDRLAETSKYKEITLKHLEQFATEGLRTLCFAVAEISES 617

Query: 560 ALKQRCGVDVDFLISQKKKLLKKQEQLKL--KQLQK------EEKLRKQAASP----KGA 607
             ++   V      S + +LLK +E  +L  K LQ       E+KL+ Q          A
Sbjct: 618 DFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKA 677

Query: 608 SVSINVNTSLEDMRSNNV-EDCKMMQVSSG-DKMEDATANGQEDSKAPDGSTLKALGLPQ 665
            + I + T  +   + N+   CK+++ + G   + + + +G  ++ +   +TL      +
Sbjct: 678 DIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSLDGTRETLSRHCTTLGDALRKE 737

Query: 666 PDFHSLILDLGALSFVDT 683
            DF +LI+D   L +  T
Sbjct: 738 NDF-ALIIDGKTLKYALT 754


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score = 32.0 bits (71), Expect = 2.2
 Identities = 19/75 (25%), Positives = 34/75 (45%), Gaps = 1/75 (1%)

Query: 584  EQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDAT 643
            EQL  ++ QK  +L  +    +G    +++    +D+R    E+ + +Q      + +A 
Sbjct: 1350 EQLSFRERQKYFELEVRVPQAEGPPKRVSL-VGADDLRKMQEEEARKLQQKRAQMLREAA 1408

Query: 644  ANGQEDSKAPDGSTL 658
              G E   A DG TL
Sbjct: 1409 EAGAEARLALDGETL 1423


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,940,830
Number of Sequences: 37866
Number of extensions: 1083806
Number of successful extensions: 3722
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 3622
Number of HSP's gapped (non-prelim): 86
length of query: 759
length of database: 18,247,518
effective HSP length: 110
effective length of query: 649
effective length of database: 14,082,258
effective search space: 9139385442
effective search space used: 9139385442
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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