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Search of human proteins with 94681049
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94681049 hypothetical protein LOC80217 [Homo sapiens]
(1665 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94681049 hypothetical protein LOC80217 [Homo sapiens] 3310 0.0
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 84 1e-15
gi|71061468 centromere protein E [Homo sapiens] 84 1e-15
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 81 7e-15
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 81 7e-15
gi|31377846 WD repeat domain 52 [Homo sapiens] 80 2e-14
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 78 6e-14
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 78 6e-14
gi|118498362 kinectin 1 isoform b [Homo sapiens] 77 1e-13
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 77 1e-13
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 77 2e-13
gi|118498368 kinectin 1 isoform c [Homo sapiens] 75 5e-13
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 75 5e-13
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 74 2e-12
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 72 6e-12
gi|156104908 myosin heavy chain 6 [Homo sapiens] 72 6e-12
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 70 2e-11
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 70 2e-11
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 69 3e-11
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 68 6e-11
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 67 1e-10
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 67 1e-10
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 67 2e-10
gi|21735548 centrosomal protein 2 [Homo sapiens] 66 2e-10
gi|55770834 centromere protein F [Homo sapiens] 66 2e-10
gi|38044112 restin isoform b [Homo sapiens] 66 3e-10
gi|4506751 restin isoform a [Homo sapiens] 66 3e-10
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 65 4e-10
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 65 4e-10
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 65 4e-10
>gi|94681049 hypothetical protein LOC80217 [Homo sapiens]
Length = 1665
Score = 3310 bits (8582), Expect = 0.0
Identities = 1665/1665 (100%), Positives = 1665/1665 (100%)
Query: 1 MAQGRERDEGPHSAGGASLSVRWVQGFPKQNVHFVNDNTICYPCGNYVIFINIETKKKTV 60
MAQGRERDEGPHSAGGASLSVRWVQGFPKQNVHFVNDNTICYPCGNYVIFINIETKKKTV
Sbjct: 1 MAQGRERDEGPHSAGGASLSVRWVQGFPKQNVHFVNDNTICYPCGNYVIFINIETKKKTV 60
Query: 61 LQCSNGIVGVMATNIPCEVVAFSDRKLKPLIYVYSFPGLTRRTKLKGNILLDYTLLSFSY 120
LQCSNGIVGVMATNIPCEVVAFSDRKLKPLIYVYSFPGLTRRTKLKGNILLDYTLLSFSY
Sbjct: 61 LQCSNGIVGVMATNIPCEVVAFSDRKLKPLIYVYSFPGLTRRTKLKGNILLDYTLLSFSY 120
Query: 121 CGTYLASYSSLPEFELALWNWESSIILCKKSQPGMDVNQMSFNPMNWRQLCLSSPSTVSV 180
CGTYLASYSSLPEFELALWNWESSIILCKKSQPGMDVNQMSFNPMNWRQLCLSSPSTVSV
Sbjct: 121 CGTYLASYSSLPEFELALWNWESSIILCKKSQPGMDVNQMSFNPMNWRQLCLSSPSTVSV 180
Query: 181 WTIERSNQEHCFRARSVKLPLEDGSFFNETDVVFPQSLPKDLIYGPVLPLSAIAGLVGKE 240
WTIERSNQEHCFRARSVKLPLEDGSFFNETDVVFPQSLPKDLIYGPVLPLSAIAGLVGKE
Sbjct: 181 WTIERSNQEHCFRARSVKLPLEDGSFFNETDVVFPQSLPKDLIYGPVLPLSAIAGLVGKE 240
Query: 241 AETFRPKDDLYPLLHPTMHCWTPTSDLYIGCEEGHLLMINGDTLQVTVLNKIEEESPLDR 300
AETFRPKDDLYPLLHPTMHCWTPTSDLYIGCEEGHLLMINGDTLQVTVLNKIEEESPLDR
Sbjct: 241 AETFRPKDDLYPLLHPTMHCWTPTSDLYIGCEEGHLLMINGDTLQVTVLNKIEEESPLDR 300
Query: 301 RNFISPVTLVYQKEGVLASGIDGFVYSFIIKDRSYMIEDFLEIERPVEHMTFSPNYTVLL 360
RNFISPVTLVYQKEGVLASGIDGFVYSFIIKDRSYMIEDFLEIERPVEHMTFSPNYTVLL
Sbjct: 301 RNFISPVTLVYQKEGVLASGIDGFVYSFIIKDRSYMIEDFLEIERPVEHMTFSPNYTVLL 360
Query: 361 IQTDKGSVYIYTFGKEPTLNKVLDACDGKFQAIDFITPGTQYFMTLTYSGEICVWWLEDC 420
IQTDKGSVYIYTFGKEPTLNKVLDACDGKFQAIDFITPGTQYFMTLTYSGEICVWWLEDC
Sbjct: 361 IQTDKGSVYIYTFGKEPTLNKVLDACDGKFQAIDFITPGTQYFMTLTYSGEICVWWLEDC 420
Query: 421 ACVSKIYLNTLATVLACCPSSLSAAVGTEDGSVYFISVYDKESPQVVHKAFLSESSVQHV 480
ACVSKIYLNTLATVLACCPSSLSAAVGTEDGSVYFISVYDKESPQVVHKAFLSESSVQHV
Sbjct: 421 ACVSKIYLNTLATVLACCPSSLSAAVGTEDGSVYFISVYDKESPQVVHKAFLSESSVQHV 480
Query: 481 VYDQQGIFLLVGTAEGKVFIINANSSSSFQIIGFTEVAKDILQISTVSLLETDIVEVMVL 540
VYDQQGIFLLVGTAEGKVFIINANSSSSFQIIGFTEVAKDILQISTVSLLETDIVEVMVL
Sbjct: 481 VYDQQGIFLLVGTAEGKVFIINANSSSSFQIIGFTEVAKDILQISTVSLLETDIVEVMVL 540
Query: 541 SSLPEAGRSRLEMFTLPTLLPQVSTTFADERGRLKDEIIHKYLYELEHALSSAVLGFQSN 600
SSLPEAGRSRLEMFTLPTLLPQVSTTFADERGRLKDEIIHKYLYELEHALSSAVLGFQSN
Sbjct: 541 SSLPEAGRSRLEMFTLPTLLPQVSTTFADERGRLKDEIIHKYLYELEHALSSAVLGFQSN 600
Query: 601 QIYGFCSQVPYICSYLLPEEEHTGIYILKPYKKVQSRQYGPGLLYLSSHGLWLITIAKCG 660
QIYGFCSQVPYICSYLLPEEEHTGIYILKPYKKVQSRQYGPGLLYLSSHGLWLITIAKCG
Sbjct: 601 QIYGFCSQVPYICSYLLPEEEHTGIYILKPYKKVQSRQYGPGLLYLSSHGLWLITIAKCG 660
Query: 661 ILCIRDVYTLETFAWCRSHSHQGHGIQSMRISMDGQNILVNGRDDGTLVYLKWKRFGGHL 720
ILCIRDVYTLETFAWCRSHSHQGHGIQSMRISMDGQNILVNGRDDGTLVYLKWKRFGGHL
Sbjct: 661 ILCIRDVYTLETFAWCRSHSHQGHGIQSMRISMDGQNILVNGRDDGTLVYLKWKRFGGHL 720
Query: 721 ASEILDYYQKLLISLSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQDELVLTD 780
ASEILDYYQKLLISLSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQDELVLTD
Sbjct: 721 ASEILDYYQKLLISLSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQDELVLTD 780
Query: 781 VKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQ 840
VKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQ
Sbjct: 781 VKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQ 840
Query: 841 EFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFH 900
EFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFH
Sbjct: 841 EFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFH 900
Query: 901 IPCVVENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDE 960
IPCVVENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDE
Sbjct: 901 IPCVVENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDE 960
Query: 961 EEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDIIYKVK 1020
EEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDIIYKVK
Sbjct: 961 EEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDIIYKVK 1020
Query: 1021 TVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQD 1080
TVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQD
Sbjct: 1021 TVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQD 1080
Query: 1081 EEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVI 1140
EEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVI
Sbjct: 1081 EEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVI 1140
Query: 1141 PQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAF 1200
PQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAF
Sbjct: 1141 PQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAF 1200
Query: 1201 DEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTS 1260
DEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTS
Sbjct: 1201 DEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTS 1260
Query: 1261 EAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQK 1320
EAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQK
Sbjct: 1261 EAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQK 1320
Query: 1321 THSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAK 1380
THSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAK
Sbjct: 1321 THSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAK 1380
Query: 1381 VENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTIQI 1440
VENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTIQI
Sbjct: 1381 VENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTIQI 1440
Query: 1441 LLKQGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQI 1500
LLKQGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQI
Sbjct: 1441 LLKQGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQI 1500
Query: 1501 EWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDKM 1560
EWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDKM
Sbjct: 1501 EWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDKM 1560
Query: 1561 HKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAMGSKLTCEKIV 1620
HKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAMGSKLTCEKIV
Sbjct: 1561 HKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAMGSKLTCEKIV 1620
Query: 1621 KERYENMMQQQKLTNISKQQAEQISILQTEVERLRMKTFPALVQM 1665
KERYENMMQQQKLTNISKQQAEQISILQTEVERLRMKTFPALVQM
Sbjct: 1621 KERYENMMQQQKLTNISKQQAEQISILQTEVERLRMKTFPALVQM 1665
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 84.0 bits (206), Expect = 1e-15
Identities = 170/864 (19%), Positives = 357/864 (41%), Gaps = 111/864 (12%)
Query: 772 SQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKL 831
S+ E +T +KKE+ E I V L ++ KE K I SLSK + ++ N +L
Sbjct: 1335 SEKESCITQLKKEL-------SENINA-VTLMKEELKEKKVEISSLSKQLTDL---NVQL 1383
Query: 832 ENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDV--EMHNLAKSYLAELIKEECWNSM 889
+N L ++E + L + +DE + E+ ++D+ ++ L+K ++ L + + W++
Sbjct: 1384 QNSISLSEKEAA--ISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNK 1441
Query: 890 AVKGRALKCFHIPCVVENFPMKARTVEELK-ELERVLQQKKIEAECLKLRKEIVEAQSGV 948
+ + F TV+EL+ +LE ++ + E + L KE ++ Q+
Sbjct: 1442 FSEWKKK-------AQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKR 1494
Query: 949 KLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQ 1008
+ EDD+ + E+ K SNL L + ++ + +E+ S E +
Sbjct: 1495 FDCLKGEMEDDKSKMEK----KESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKN 1550
Query: 1009 IILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFED 1068
KDI +K F ++K+ + +E+ + + + ++ E + E E
Sbjct: 1551 YNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEH 1610
Query: 1069 C-----EKPERTLVVQD--EEITAHKHIKPWHKAKELIV--------------------- 1100
K E ++D E +A K + KA++ I
Sbjct: 1611 VNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGT 1670
Query: 1101 -NHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERK 1159
+H E +Q+ + L + + V + E +++P+ AK A +TE+E
Sbjct: 1671 ESHLSELNTKLQEREREVHILEEKLKSVESSQSE---TLIVPR---SAKNVAAYTEQEEA 1724
Query: 1160 QF-----KDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLK---RLFERR 1211
K YE+K+ L +++L + K LQ QE + H + + ER
Sbjct: 1725 DSQGCVQKTYEEKISVL-------QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERL 1777
Query: 1212 VKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLD 1271
+K E ++ S + L EEL + K + L QH + + + +++++L+
Sbjct: 1778 IKLEHAEAKQHEDQSMIGH---LQEELEEKNKKYS--LIVAQHVEKEGGKNNIQAKQNLE 1832
Query: 1272 VCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTHSETTSVVPF 1331
+ L E ++ + +++ E+ D K R+ ++ S+ +
Sbjct: 1833 NVFDDVQKTLQEKELTCQILEQKIKEL-----DSCLVRQKEVHRVEMEELTSKYEKLQAL 1887
Query: 1332 GELPGSGK----LNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENE-QK 1386
++ G K L ++ + + + +SNM + L + + A E E QK
Sbjct: 1888 QQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEF------KLAGAEREKQK 1941
Query: 1387 VKQKAADLLEMATFLQKRVEEE-EKVQQEIERVFHELILLQEEKVRFQLNLTIQILLKQG 1445
+ ++ L + L+K ++E E +++E ++ E I ++E + + N T++ L+++
Sbjct: 1942 LGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREF 2001
Query: 1446 QVELENFQLVLEYSDAILINK--NIIEDLNSVIRTQGQKKVASMMESKDVHKRILQ---- 1499
+L + LE + INK + +L + + + + + E D KR +
Sbjct: 2002 NTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEE 2061
Query: 1500 -IEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLD 1558
++ ++M + DL + ++Q + + Q+ + ++ +Q + ++T + D
Sbjct: 2062 ILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISD 2121
Query: 1559 KMHK-----KNVENCKKLLKKLGK 1577
K + + N + LKK K
Sbjct: 2122 SKLKEQEFREQIHNLEDRLKKYEK 2145
Score = 75.5 bits (184), Expect = 4e-13
Identities = 186/919 (20%), Positives = 387/919 (42%), Gaps = 178/919 (19%)
Query: 793 QEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEELERL 852
Q+ +K++ NL K K+ I+S + + E + L+ +LD++ L+ELE++
Sbjct: 285 QQRVKRQENLL----KRCKETIQSHKEQCTLLTSEKEALQE--QLDER-----LQELEKI 333
Query: 853 HDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKA 912
D E K+I + AK+ + +L +++ K + + E MK
Sbjct: 334 KDLHMAEKTKLITQLRD---AKNLIEQLEQDKGMVIAETKRQ---------MHETLEMKE 381
Query: 913 RTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIK-----QRHEED----DEEEE 963
EE+ +L ++Q + E L+ +KE E + +L K Q+ EE E +
Sbjct: 382 ---EEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMD 438
Query: 964 EEDKTVKYSNLPNYLLGSLSTDFG------VDTSLLSSQLELHSREEKINQIILLK---D 1014
E+ KT++ ++ + SL + VD SS+ ++ ++ +K+++ L + +
Sbjct: 439 EQIKTIEKTSEEERI--SLQQELSRVKQEVVDVMKKSSEEQI-AKLQKLHEKELARKEQE 495
Query: 1015 IIYKVKT---VFNNEFDAAYKQKEFEIARVKERNVRIREIIL-DLELEEAVWQPEFEDC- 1069
+ K++T F + A ++ + E ++ + + + L +LEL++ E E+
Sbjct: 496 LTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKL 555
Query: 1070 ------EKPERTLVVQDEEITAHKHIKPWHKAKELIVN-------HEKEHWLLIQDASTR 1116
+ RT +++ E + +++K+L V+ H KE ++++ T
Sbjct: 556 RDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE 615
Query: 1117 LRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERD 1176
L +L + DA+WTE+ + + Y+ ++++L E+ +
Sbjct: 616 LESLKH-------------------------QQDALWTEKLQVLKQQYQTEMEKLREKCE 650
Query: 1177 KYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDE 1236
+ +++L +++ F H++ + E+ ++ ++ Q EL+ + S L E
Sbjct: 651 QEKETL----------LKDKEIIFQAHIEEMNEKTLE-KLDVKQTELE----SLSSELSE 695
Query: 1237 ELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFS 1296
L +R K K E K E + ++ D+++ E +V + +K
Sbjct: 696 VLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALK 755
Query: 1297 EIPGHQVDILYKLFKRRPR-ISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDEL 1355
+ Q++ L L K R + + + + H E A + ++ EL
Sbjct: 756 D----QINQLELLLKERDKHLKEHQAHVENLE------------------ADIKRSEGEL 793
Query: 1356 DNISNMPEGLDPLVWNHFCMTRRAKVENEQ--KVKQKAADLLEMATFLQKRVEEEEKVQQ 1413
S LD + K EQ +++QK DL L K+V E E ++
Sbjct: 794 QQAS---AKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKK 850
Query: 1414 EI--ERVFHEL----ILLQEEKVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKN 1467
++ E H++ ++ Q EK ++ ++ L + + +LE+ E + IL+ K
Sbjct: 851 DVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKE 910
Query: 1468 IIEDLNSVIR-TQGQKKVASMMESK------DVHKRILQIEWEHKKMEMEREDLNQKAWD 1520
N +++ +GQKK ++ K +H + E + K E + E + QKA +
Sbjct: 911 -----NMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKE 965
Query: 1521 IQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSN 1580
+Q ++K L++ EA + + +E T L+ K+ N K L +
Sbjct: 966 MQETL----KKKLLDQ---EAKLKKE---LENT--ALELSQKEKQFNAKMLEMAQANSAG 1013
Query: 1581 QKDIANYALSCNLREELVAVSE--RKDICNAMGSKLTCEKIVKERYENMMQQQKLTNISK 1638
D + L N +E++ +++E R+++ + + EK + ++ E + Q++ I
Sbjct: 1014 ISDAVS-RLETNQKEQIESLTEVHRRELNDVIS---IWEKKLNQQAEEL---QEIHEIQL 1066
Query: 1639 QQAEQISILQTEVERLRMK 1657
Q+ EQ EV L+ K
Sbjct: 1067 QEKEQ------EVAELKQK 1079
Score = 67.8 bits (164), Expect = 8e-11
Identities = 164/793 (20%), Positives = 335/793 (42%), Gaps = 111/793 (13%)
Query: 755 DLGSDSEHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGI 814
D G TK++ L E + ++ I + + +E +++ +E+++ +
Sbjct: 361 DKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKAL 420
Query: 815 KSLSKTILNMM----EENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMH 870
+ KT E +++++ I K ++E +EL R+ E + V K + ++
Sbjct: 421 STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVD-VMKKSSEEQIA 479
Query: 871 NLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKI 930
L K + EL ++E + ++ R + V ++ E LK + QQ+ +
Sbjct: 480 KLQKLHEKELARKEQELTKKLQTREREFQEQMKVA----LEKSQSEYLKISQEKEQQESL 535
Query: 931 EAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDT 990
E L+L+K+ + +S KL D ++E E + L + L SL +
Sbjct: 536 ALEELELQKKAILTESENKL-------RDLQQEAETYRTRILELESSLEKSLQENKNQSK 588
Query: 991 SL---LSSQLELHSREEKI---NQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKER 1044
L L ++ H++E + L+ + ++ ++ + +Q + E+ +++E+
Sbjct: 589 DLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK 648
Query: 1045 NVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEK 1104
+ +E +L + +E ++Q E E E+TL D + T + + ++ L H+
Sbjct: 649 CEQEKETLL--KDKEIIFQAHIE--EMNEKTLEKLDVKQTELESLSS-ELSEVLKARHKL 703
Query: 1105 EHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDY 1164
E L + L+ D M LE K ++ Q + K V + K KD
Sbjct: 704 EEELSV------LKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQ 757
Query: 1165 EKKVKELNEERDKYRK-------SLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMV 1217
+++ L +ERDK+ K +LEA++K+ + +Q+++ D +F+ A
Sbjct: 758 INQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLD-----VFQSYQSA--- 809
Query: 1218 TNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHY 1277
E+ K +E+L+ ++ L + T + Q +E + + DVC E
Sbjct: 810 -THEQTK--------AYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKK---DVCTELD 857
Query: 1278 DNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTHSETTSVVPFGE---- 1333
+ + +M + +K+ SE+ +V L ++++ + K +T ++ E
Sbjct: 858 AHKIQVQDLM-QQLEKQNSEME-QKVKSLTQVYESKLE-DGNKEQEQTKQILVEKENMIL 914
Query: 1334 -LPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKAA 1392
+ K + Q + A ++ +I N + + + + +KVKQKA
Sbjct: 915 QMREGQKKEIEILTQKLSAKEDSIHILN----------EEYETKFKNQEKKMEKVKQKAK 964
Query: 1393 DLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTIQILLKQGQVELENF 1452
++ E T +K +++E K+++E+E L L Q+EK Q N
Sbjct: 965 EMQE--TLKKKLLDQEAKLKKELENT--ALELSQKEK---QFNAK--------------- 1002
Query: 1453 QLVLEYSDAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQ--IEWEHKKMEME 1510
+LE + A N I D S + T ++++ S+ E VH+R L I KK+ +
Sbjct: 1003 --MLEMAQA---NSAGISDAVSRLETNQKEQIESLTE---VHRRELNDVISIWEKKLNQQ 1054
Query: 1511 REDLNQKAWDIQM 1523
E+L Q+ +IQ+
Sbjct: 1055 AEEL-QEIHEIQL 1066
Score = 63.2 bits (152), Expect = 2e-09
Identities = 161/739 (21%), Positives = 311/739 (42%), Gaps = 97/739 (13%)
Query: 723 EILDYYQKLLISLSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQDELVLTDVK 782
E+LD Q L + + + KE +S +V D + K+KA + +Q + + +++
Sbjct: 1409 ELLDQVQDLSFKVDT-LSKEK--ISALEQVD-DWSNKFSEWKKKAQSRFTQHQNTVKELQ 1464
Query: 783 KEIPWIQQKSQEAIKKE--VNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQ 840
++ + KS+EA +K+ +NL ++E+ Q K M ++ K+E +
Sbjct: 1465 IQL---ELKSKEAYEKDEQINLL---KEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET 1518
Query: 841 EFGLDLEELERLHD---------ESQEEVAKMI---KDVEMHNLAKS--YLAELIKEECW 886
E + L D ES EV K KD+E L + + EL +E+
Sbjct: 1519 ELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDN 1578
Query: 887 NSMAVKGRALKCFHIPCVVEN--FPMKARTVEELKELERVLQQKKIEAECLKLRKEIVEA 944
+ + L +EN + MKA + KELE V K + E LK ++ +E+
Sbjct: 1579 RVKEAEEKIL-------TLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLES 1631
Query: 945 QSGVKL--IKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSR 1002
+S KL +K++ E+ +++ + Y G+ S ++T L + E+H
Sbjct: 1632 ESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHIL 1691
Query: 1003 EEKINQIILLKDIIYKVKTVFNNEFDAAYKQKE------------FEIARVKERNVRIRE 1050
EEK+ + + V N AAY ++E E V +RN+ +E
Sbjct: 1692 EEKLKSVESSQSETLIVPRSAKNV--AAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKE 1749
Query: 1051 IILD---LELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHW 1107
+L E EE V C+ ER + ++ E H+ +E + K++
Sbjct: 1750 KLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYS 1809
Query: 1108 LLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERK-QFKDYEK 1166
L++ ++ GG ++ + L V D T +E++ + E+
Sbjct: 1810 LIVAQH-------VEKEGGKNNIQAKQNLENVF--------DDVQKTLQEKELTCQILEQ 1854
Query: 1167 KVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMV-TNQEELKI 1225
K+KEL+ + ++ E+++L S E QA L+++ R E++ N EE
Sbjct: 1855 KIKELDSCLVRQKEVHRVEMEEL-TSKYEKLQA----LQQMDGRNKPTELLEENTEEKSK 1909
Query: 1226 SNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVC-KEHYDNLLAED 1284
S+L LL + ++ L L + EK + + + + ++DL + KEH L
Sbjct: 1910 SHLVQPKLL-SNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQEL---- 1964
Query: 1285 KVMDRSFKKEFSE-IPGHQVDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNK- 1342
+++ + + +E E I Q D+ K ++ ++ +++ E+ +NK
Sbjct: 1965 EILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMRE-FNTQLAQKEQELEMTIKETINKA 2023
Query: 1343 -DAFAQLMKAMDELDN--ISNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEMAT 1399
+ A+L+++ E N + + E D L +R E+ + + ++
Sbjct: 2024 QEVEAELLESHQEETNQLLKKIAEKDDDL--------KRTAKRYEEILDAREEEMTAKVR 2075
Query: 1400 FLQKRVEE-EEKVQQEIER 1417
LQ ++EE ++K QQ++E+
Sbjct: 2076 DLQTQLEELQKKYQQKLEQ 2094
Score = 46.6 bits (109), Expect = 2e-04
Identities = 177/959 (18%), Positives = 374/959 (38%), Gaps = 119/959 (12%)
Query: 764 KQKASTDLSQDELVL----TDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSK 819
K++ +L Q L+ ++ KEI W+++ E +K++ L E+++ +K S
Sbjct: 1069 KEQEVAELKQKILLFGCEKEEMNKEITWLKE---EGVKQDTTL-----NELQEQLKQKSA 1120
Query: 820 TILNMMEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSYLAE 879
+ ++ ++ KL+ A L++ E L+ E + Q KM+ + + +++ L
Sbjct: 1121 HVNSLAQDETKLK--AHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSE--LTS 1176
Query: 880 LIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKIEAECLKLRK 939
+K ++K K +E+ ++ + + E ++ + KK EA
Sbjct: 1177 KLKTTDEEFQSLKSSHEKSNKS---LEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTN 1233
Query: 940 EIVEAQSGV------KLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLL 993
E++ S ++ +H +E KT S L L +T +
Sbjct: 1234 ELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQ---NTLNI 1290
Query: 994 SSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIIL 1053
S Q H EEK NQI +K I + T E +A K+ + E+ I + L
Sbjct: 1291 SFQQATHQLEEKENQIKSMKADIESLVT----EKEALQKEGGNQQQAASEKESCITQ--L 1344
Query: 1054 DLELEE-----AVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWL 1108
EL E + + E ++ + +L Q ++ KE ++ ++ +
Sbjct: 1345 KKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQY- 1403
Query: 1109 LIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKV 1168
++ L + D+ V + KE I + Q + + W ++ + +F ++ V
Sbjct: 1404 -DEEKCELLDQVQDLSFKVDTLSKEKI--SALEQVDDWSNKFSEWKKKAQSRFTQHQNTV 1460
Query: 1169 KELN---EERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTN--QEEL 1223
KEL E + K + ++ L+ + + + FD + + + K E + + EL
Sbjct: 1461 KELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETEL 1520
Query: 1224 KISNLAFSLLLDE------ELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHY 1277
K L D E+ S + L NY +K E + + ++ +E E
Sbjct: 1521 KSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQE----LGEEK 1576
Query: 1278 DNLL--AEDKVMD-----RSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTHSETTSVVP 1330
DN + AE+K++ S K E + + + + + E+ S
Sbjct: 1577 DNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAK 1636
Query: 1331 FGELPGSGKLNKDAF-AQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQKV-- 1387
EL + A QL+ M+E + +G + +H E E++V
Sbjct: 1637 LAELKRKAEQKIAAIKKQLLSQMEEKE--EQYKKGTE----SHLSELNTKLQEREREVHI 1690
Query: 1388 ---KQKAADLLEMATFLQKR---------VEEEEKVQQEIERVFHELILLQEEKVRFQLN 1435
K K+ + + T + R +EE Q +++ + E I + + + +
Sbjct: 1691 LEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEK 1750
Query: 1436 LTIQILLKQGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQKKVASMMES-KDVH 1494
L ++ ++ + +F++ +Y + ++ ++ + + Q + + E ++ +
Sbjct: 1751 LLQRVGQEKEETVSSHFEMRCQYQERLIKLEHA-----EAKQHEDQSMIGHLQEELEEKN 1805
Query: 1495 KRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTI 1554
K+ I +H + E + ++ K +++ +F D QK L E + I+EQ I
Sbjct: 1806 KKYSLIVAQHVEKEGGKNNIQAKQ-NLENVF--DDVQKTLQEK------ELTCQILEQKI 1856
Query: 1555 AVLD-------KMHKKNVENCKKLLKKLGKFSNQ--KDIANYALSCNLREELVA------ 1599
LD ++H+ +E +KL ++ L N E+ +
Sbjct: 1857 KELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPK 1916
Query: 1600 -VSERKDICNAMGSKLTCEKIVKERY--ENMMQQQKLTNISKQQAEQISILQTEVERLR 1655
+S + N + KL + K++ E + Q+ L + K+ +++ IL+ E ++ R
Sbjct: 1917 LLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQER 1975
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 83.6 bits (205), Expect = 1e-15
Identities = 194/993 (19%), Positives = 418/993 (42%), Gaps = 152/993 (15%)
Query: 732 LISLSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQDELVLTDVKKEIPWIQQK 791
+++LS K + S+ + +L ++ ++K T Q+ L + KE +
Sbjct: 847 IVNLSKEAQK---FDSSLGALKTELSYKTQELQEK--TREVQERLNEMEQLKEQLENRDS 901
Query: 792 SQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEELER 851
+ + +++E L ++K ++ + +K+L++ ++ +L+ ++++ + D+ +
Sbjct: 902 TLQTVEREKTLITEKLQQTLEEVKTLTQE----KDDLKQLQESLQIERDQLKSDIHDTVN 957
Query: 852 LHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMK 911
++ ++QE++ ++ ++ H + L I EE V N M+
Sbjct: 958 MNIDTQEQLRNALESLKQHQETINTLKSKISEE-------------------VSRNLHME 998
Query: 912 ARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKY 971
T E E QQK + + +K+ +EA++ L +D+E E++ K
Sbjct: 999 ENTGETKDE----FQQKMVGID----KKQDLEAKNTQTLTAD--VKDNEIIEQQRKIFSL 1048
Query: 972 SNLPNYLLGSLSTDFGVDTSLLSSQLE-LHSREEKINQIILLKDIIYKVKTVFNNEFDAA 1030
N L L + L + E + E ++ LL D + K + + E + A
Sbjct: 1049 IQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHA 1108
Query: 1031 YKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIK 1090
K KE E++R +R + E +L+E Q + EK ++ L VQ+E K I
Sbjct: 1109 IK-KEGELSRTCDRLAEVEE-----KLKEKSQQLQ----EKQQQLLNVQEEMSEMQKKIN 1158
Query: 1091 PWHKAKELIVNHEKEHWLLIQDAST-RLRALMDMMGGVLEVKKEDILRMVIP--QPAFMA 1147
K + N E L ++ T RL + EVK R V+ Q +F
Sbjct: 1159 EIENLKNELKNKE----LTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSF-- 1212
Query: 1148 KPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRL 1207
E ER + Y ++++ + + K LK+ Q +I E ++ E ++
Sbjct: 1213 -------ETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQI 1265
Query: 1208 FERRVKAEMVTN-QEELKISNLAFSLLLD-EELSSREKFLNNY--------------LTR 1251
+ + T QEE+ + + LL + +E+S ++ +N L R
Sbjct: 1266 INTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLAR 1325
Query: 1252 KQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKL-- 1309
+ E+ + +E ++S+E++ + DNL K + + + + ++ H + L K+
Sbjct: 1326 IEMERLRLNEKFQESQEEIKSLTKERDNL----KTIKEALEVKHDQLKEHIRETLAKIQE 1381
Query: 1310 --FKRRPRISKQKTHSETTSVVPFG---------------ELPGSGKLNKDAFAQLMKAM 1352
K+ ++ ++ +ETT +V E+ G K +++ ++
Sbjct: 1382 SQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVA 1441
Query: 1353 DELDNISNMPEGL----DPLVWN-HFCMTRRAKVENEQKV-----KQKAADLLEMATFLQ 1402
E D++ + E L D L N + + + E E KV K++ + E+ L
Sbjct: 1442 KEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLS 1501
Query: 1403 KRVEEEEKVQQEIE----RVFHELILLQEEKVRFQLNLTIQILLKQGQVELENFQLVLEY 1458
++ E +Q+++E ++ +++ + E++ +F + ++ K EL+ F+ +
Sbjct: 1502 EKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVN--ELKQFKEHRKA 1559
Query: 1459 SDAIL--INKNIIEDLNSVIRTQGQKKVASMMESKDVHKRI---LQIEWEH-----KKME 1508
D+ L I ++E N + + Q+++ M++ K+ KR+ LQIE + K++
Sbjct: 1560 KDSALQSIESKMLELTNRL--QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIV 1617
Query: 1509 MEREDLNQKAWD-IQMLFFSRDRQK-----YLNEPNYEALISIQIGIMEQTIAVLDKMHK 1562
+ ++ +K + ++M + ++K +L E ++++ I + I + +H
Sbjct: 1618 AKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLE-NIETENIRLTQILH- 1675
Query: 1563 KNVENCKKLLKK---LGKFSNQKDIANYALSCNLREELVAVSERKDICNAMGSKLTCEKI 1619
+N+E + + K+ L + L NLRE + E+++ + L
Sbjct: 1676 ENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHL----- 1730
Query: 1620 VKERYENMMQQQKLTNISKQQAEQISILQTEVE 1652
KE E + KL I ++ +IS +Q ++E
Sbjct: 1731 -KEHQETI---DKLRGIVSEKTNEISNMQKDLE 1759
Score = 77.0 bits (188), Expect = 1e-13
Identities = 214/1060 (20%), Positives = 439/1060 (41%), Gaps = 176/1060 (16%)
Query: 722 SEILDYYQKLLISLSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQDELVLTDV 781
+EI++ +K+ SL ++ L + L +D + + + + L+ ++
Sbjct: 1036 NEIIEQQRKIF-SLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDEL 1094
Query: 782 KKEIPWIQQKSQEAIKKEVNL---------FSKKRKEIKQGIKSLSKTILNMMEEN---- 828
KK+ + Q+ AIKKE L +K KE Q ++ + +LN+ EE
Sbjct: 1095 KKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQ 1154
Query: 829 ---DKLENIA-KLDQQEFGLDLEELERLH-----DESQEEVAKMIKDVE-MHNLAKSYLA 878
+++EN+ +L +E L+ E ERL +E+ EEV + K+ + + L KS+
Sbjct: 1155 KKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFET 1214
Query: 879 E------LIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELK-----ELERVLQQ 927
E I+E + K LK HI + T++EL+ + +++
Sbjct: 1215 ERDHLRGYIREIEATGLQTK-EELKIAHI-----HLKEHQETIDELRRSVSEKTAQIINT 1268
Query: 928 KKIEAECLKLRKEIV---EAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLST 984
+ +E KL++EI E Q + +K+ E + E E T + + + L
Sbjct: 1269 QDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLAR--- 1325
Query: 985 DFGVDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKER 1044
++ L + +E+I + +D + +K + D + +A+++E
Sbjct: 1326 ---IEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQES 1382
Query: 1045 NVRIREIILDLELEEAVWQ--PEFEDCEKPERTLV-VQDEEITAHKHIKPWHKAKELIVN 1101
+ + + E + + E E + + L+ ++ E + K ++ H + +
Sbjct: 1383 QSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAK 1442
Query: 1102 HEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQ- 1160
+ + L+ L +++ + KE+I +V + TEEE K
Sbjct: 1443 EKDD-----------LQRLQEVLQSESDQLKENIKEIVAKH---------LETEEELKVA 1482
Query: 1161 ---FKDYEKKVKEL-------NEERDKYRKSLEAELKKLQNSIQESTQAFDE-HLKRLFE 1209
K+ E+ + EL E +K LEA KLQN IQE + ++ ++K++ E
Sbjct: 1483 HCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISE 1542
Query: 1210 RRVKA-EMVTNQEELKISNLAFSLLLDEELSSREKFLNN-----YLTRKQHEKSQTSEAV 1263
+ K E+ +E K + A + + L + + + +++ E + EA+
Sbjct: 1543 VQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEAL 1602
Query: 1264 RKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQV----DILYKLFKRRPRISKQ 1319
+ R+ L KE+ ++A+ M S +KE+ + V + + ++ + + Q
Sbjct: 1603 QIERDQL---KENTKEIVAK---MKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQ 1656
Query: 1320 KTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGL----DPLVWN-HFC 1374
K + E E ++ + ++ E D++ ++ E L D L N
Sbjct: 1657 KLNLENIET----ENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRET 1712
Query: 1375 MTRRAKVENEQKV-----KQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEK 1429
+TR + + E K+ K+ + ++ + ++ E +Q+++E ++ + Q+ K
Sbjct: 1713 ITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEH-SNDALKAQDLK 1771
Query: 1430 VRFQLNLTIQILLKQGQV-------------ELENFQLVLEYSDAILINKNIIEDLNSVI 1476
++ +L + L +Q + +L N Q LE S+A L K I++L +
Sbjct: 1772 IQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEK--IQELKANE 1829
Query: 1477 R---------TQGQKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAW----DIQM 1523
+ QKKV+ M + K K+I K+E+E +L QK +++
Sbjct: 1830 HQLITLKKDVNETQKKVSEMEQLK---KQIKDQSLTLSKLEIENLNLAQKLHENLEEMKS 1886
Query: 1524 LFFSRDRQKYLNEPNYEALISIQIGIME------------QTIAVLDKMHKKNVENCK-K 1570
+ RD + + E ++ + E +T +L K HK+ V+ + K
Sbjct: 1887 VMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREK 1946
Query: 1571 LLKKLGKFSN-QKDI--ANYALSCNLRE----ELVAVSERKDICNAMGSKLTCEKIVKER 1623
+ +K + S+ QKD+ + L ++E EL + ++D+ N K+ + +K++
Sbjct: 1947 ISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDV-NMSHKKINEMEQLKKQ 2005
Query: 1624 YE--NMMQQQ------KLTNISKQQAEQISILQTEVERLR 1655
+E N+ Q +LT + E+I I+ E + LR
Sbjct: 2006 FEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELR 2045
Score = 73.2 bits (178), Expect = 2e-12
Identities = 185/977 (18%), Positives = 389/977 (39%), Gaps = 135/977 (13%)
Query: 759 DSEHTKQKASTDLSQDELVLTDVKKEIPWI----QQKSQEAIKKEVNLFSKKRKEIKQGI 814
+ E T + +LS+ E ++ ++K++ I Q K QE +KE K+ E+++ +
Sbjct: 1488 EQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKV 1547
Query: 815 KSLSKTILNMMEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHN--- 871
L + + ++ L++I + EL ESQEE+ MIK+ E
Sbjct: 1548 NELKQFKEHRKAKDSALQSIES--------KMLELTNRLQESQEEIQIMIKEKEEMKRVQ 1599
Query: 872 ----LAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKEL--ERVL 925
+ + L E KE + + + + V E K +E LKE + L
Sbjct: 1600 EALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNET-QEKMCEIEHLKEQFETQKL 1658
Query: 926 QQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTD 985
+ IE E ++L + + E ++ + + E DD EE V+ L L +++ D
Sbjct: 1659 NLENIETENIRLTQILHENLEEMRSVTK--ERDDLRSVEETLKVERDQLKENLRETITRD 1716
Query: 986 FGVDTSLLSSQLELHSREEKINQIILLKDIIY-KVKTVFNNEFDAAYK-----------Q 1033
L + L +E I++ L+ I+ K + N + D + Q
Sbjct: 1717 LEKQEELKIVHMHLKEHQETIDK---LRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ 1773
Query: 1034 KEFEIAR----------------VKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLV 1077
+E IA V E+ ++ + DLE A Q + ++ + E L+
Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLI 1833
Query: 1078 VQDEEIT-AHKHIKPWHKAKELIVNH-------EKEHWLLIQDASTRLRALMDMMGGVLE 1129
+++ K + + K+ I + E E+ L Q L + +M
Sbjct: 1834 TLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDN 1893
Query: 1130 VKK-EDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKK 1188
+++ E+ L++ Q + E +++ K KE E DK R+ + + +
Sbjct: 1894 LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQ 1953
Query: 1189 LQNSIQESTQAFDEHLKRLFERRVKA-EMVTNQEELKISNLAFSLLLD-------EELSS 1240
+ + ++ ++ DE K++ E + K +++ +E++ +S+ + + + LS
Sbjct: 1954 ISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSM 2013
Query: 1241 REKFLNNY-LTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIP 1299
+ ++N+ LT+K HE + V K R++L KE S K E +
Sbjct: 2014 QSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKE--------------SLKMERDQF- 2058
Query: 1300 GHQVDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNIS 1359
+ L ++ R + + K S G L + + + + L S
Sbjct: 2059 ---IATLREMIARDRQNHQVKPEKRLLS-------DGQQHLTESLREKCSRIKELLKRYS 2108
Query: 1360 NMPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVF 1419
M + + L N + ++E ++++ + L + K +E+ Q F
Sbjct: 2109 EMDDHYECL--NRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEF 2166
Query: 1420 HELILLQEEKVRFQLNLTIQILLKQ----GQVELENFQLVLEYSDAILINKNIIEDLNSV 1475
H ++ +K+++ L+ +I +Q + E++ V + + ++ +++ +D +
Sbjct: 2167 HRIM----KKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVP 2222
Query: 1476 IRTQGQKKVASMME--SKDVHKRILQIEWEHKKMEMEREDLNQK------------AWDI 1521
R K+ M+ +++ K + E+ K E ++ N+K +DI
Sbjct: 2223 SRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDI 2282
Query: 1522 QML----FFSRDRQKYLNEPNYEALISI--QIGIMEQTIAVLDKMHKKNVENCKKLLKKL 1575
+ L DR +N +I+I + E+ A + K ++++++ K+ +KL
Sbjct: 2283 EKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKL 2342
Query: 1576 GKFSNQKDIANYALSCNLREELVAVSERKDICNAMGSKLTCEKIVKERYENMMQQQKLTN 1635
F N + + +L+ + + + ++LT EKI EN + + K +
Sbjct: 2343 --FKNYQTLKT-SLASGAQVNPTTQDNKNPHVTSRATQLTTEKI--RELENSLHEAKESA 2397
Query: 1636 ISKQQAEQISILQTEVE 1652
+ K+ +I +Q E+E
Sbjct: 2398 MHKE--SKIIKMQKELE 2412
Score = 66.2 bits (160), Expect = 2e-10
Identities = 186/946 (19%), Positives = 382/946 (40%), Gaps = 178/946 (18%)
Query: 770 DLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEEND 829
++S DE +L +KEI ++++ +E + E + ++ ++ Q ++ K +L ++ N+
Sbjct: 337 EVSTDEALLKRYRKEIMDLKKQLEE-VSLETRAQAMEKDQLAQLLEE--KDLLQKVQ-NE 392
Query: 830 KLENIAKLDQQEFGLDLEE-------------LERLHDESQEEVAKMIK-----DVEMHN 871
K+EN+ ++ L L++ L +++ A + H
Sbjct: 393 KIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHK 452
Query: 872 LAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELE-----RVLQ 926
L+ + L E+ + C S + + T++ L E+E ++L
Sbjct: 453 LSINLLREIDESVCSES--------------------DVFSNTLDTLSEIEWNPATKLLN 492
Query: 927 QKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDF 986
Q+ IE+E LR + L+ + E+EE E K + ++L +
Sbjct: 493 QENIESELNSLRADYDN------LVLDYEQLRTEKEEMELKLKEKNDLDEF--------- 537
Query: 987 GVDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNV 1046
L + + + I++I LK+++ K V+N + + K E+ R KE +
Sbjct: 538 ----EALERKTKKDQEMQLIHEISNLKNLV-KHAEVYNQDLENELSSK-VELLREKEDQI 591
Query: 1047 RIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEH 1106
+ + E+ D +K E ++ +++ E
Sbjct: 592 KKLQ--------------EYIDSQKLENI---------------------KMDLSYSLES 616
Query: 1107 WLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEK 1166
I+D + L D L+ K+E AF+ + E +++ K+
Sbjct: 617 ---IEDPKQMKQTLFDAETVALDAKRES---------AFLRSENL----ELKEKMKELAT 660
Query: 1167 KVKELNEERDKYRKSLEAELKKLQNSIQESTQ-AFDE--HLKRLFERRVKAEMVTNQE-E 1222
K++ + Y+ LEA+ KK+Q +++ Q AF+E L L + +V +++ N E E
Sbjct: 661 TYKQMENDIQLYQSQLEAK-KKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELE 719
Query: 1223 LKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLA 1282
KI++L L++E+ E L + KS SE R +E D +E +
Sbjct: 720 GKITDLQKE--LNKEVEENEA-LREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSE 776
Query: 1283 EDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNK 1342
+DK+ KE S + G +L ++ K + ++ +++ ++T E L+
Sbjct: 777 KDKLFSEVVHKE-SRVQG----LLEEIGKTKDDLATTQSNYKSTD----QEFQNFKTLHM 827
Query: 1343 DAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQ 1402
D + ++E + ++ L K E + K +L E +Q
Sbjct: 828 DFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTE----LSYKTQELQEKTREVQ 883
Query: 1403 KRVEEEEKVQQEIERVFHELILLQEEKV----RFQLNLTIQILLKQGQVELENFQLVLEY 1458
+R+ E E++++++E L ++ EK + Q L L Q + +L+ Q L+
Sbjct: 884 ERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQI 943
Query: 1459 SDAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQI------EWEHKKMEMERE 1512
+ + +I + +N I TQ Q + A +ES H+ + E + + ME E
Sbjct: 944 -ERDQLKSDIHDTVNMNIDTQEQLRNA--LESLKQHQETINTLKSKISEEVSRNLHME-E 999
Query: 1513 DLNQKAWDIQMLFFSRDRQKYLNEPNYEALIS--IQIGIMEQTIAVLDKMHKKN------ 1564
+ + + Q D+++ L N + L + I+EQ + + +KN
Sbjct: 1000 NTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQML 1059
Query: 1565 ------VENCKKLLKKLGKFS--NQKDIANYALSCNLREELVAVSERKDICNAMGSKLTC 1616
E K LK+ + + NQ+++ ++E+VA + I TC
Sbjct: 1060 ESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTC 1119
Query: 1617 EKI------VKERYENMMQ-QQKLTNISKQQAEQISILQTEVERLR 1655
+++ +KE+ + + + QQ+L N+ ++ +E + E+E L+
Sbjct: 1120 DRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI-NEIENLK 1164
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 81.3 bits (199), Expect = 7e-15
Identities = 186/928 (20%), Positives = 368/928 (39%), Gaps = 140/928 (15%)
Query: 774 DELVLTDVKKE--IPWIQQKSQEAIKKEVNLFSKKRK------EIKQGIKSLSKTILNMM 825
D+L+ T ++ E I + +++++ + L +KKRK E+K+ I L T+ +
Sbjct: 912 DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 971
Query: 826 EENDKLENIAK-LDQQEFGLDLEELERLHDESQEEVAKMIKDVE-MHNLAKSYLAELIKE 883
+E EN K L ++ GLD E +AK+ K+ + + + L +L E
Sbjct: 972 KEKHATENKVKNLTEEMAGLD------------ETIAKLTKEKKALQEAHQQTLDDLQAE 1019
Query: 884 ECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKK-----IEAECLKLR 938
E + K K + +++ +LE L+Q+K +E KL
Sbjct: 1020 EDKVNTLTKA-----------------KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE 1062
Query: 939 KEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLE 998
++ AQ + I+ ++ DE+ ++ K + SNL + + + + + Q
Sbjct: 1063 GDLKLAQESIMDIENEKQQLDEKLKK--KEFEISNLQSKIEDEQALGIQLQKKIKELQAR 1120
Query: 999 LHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKE-------FEIARVKERNVRIREI 1051
+ EE+I + K ++ + E + ++ E +I K+R +++
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1180
Query: 1052 ILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQ 1111
DLE EA Q E ++ D + I + K+ + + E + I
Sbjct: 1181 RRDLE--EATLQHEATAATLRKKHA---DSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1235
Query: 1112 DASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKEL 1171
D ++ + + G + E + R + Q + + + EE+++ D + L
Sbjct: 1236 DLASNVETVSKAKGNL-----EKMCRTLEDQLSELKSKE----EEQQRLINDLTAQRGRL 1286
Query: 1172 NEERDKYRKSLEAELKKLQNSIQESTQAFD---EHLKRLFERRVKAE------------- 1215
E ++ + L+ E + L + + QAF E LKR E +KA+
Sbjct: 1287 QTESGEFSRQLD-EKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHD 1345
Query: 1216 ---MVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDV 1272
+ EE + S L + + ++ Y T + EA +K + L
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQA 1405
Query: 1273 CKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDI------LYKLFKRRPRISKQKTHSETT 1326
+EH + + A+ ++++ ++ +E+ +D+ L K++ K +
Sbjct: 1406 AEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQK 1465
Query: 1327 SVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQK 1386
EL S K + +L K + + E LD L K EN+
Sbjct: 1466 CEETHAELEASQKEARSLGTELFKIKNAYE------ESLDQL--------ETLKRENKN- 1510
Query: 1387 VKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEE---KVRFQLNLTIQILLK 1443
++Q+ +DL E KR+ E EK+++++E+ EL EE + + ++I L+
Sbjct: 1511 LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLE 1570
Query: 1444 QGQVELENFQLVLEYSDAI-LINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQIEW 1502
QV+ E + + E + I + +N I + S+ T A + D + ++E
Sbjct: 1571 LNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD----AEIRSRNDAIRLKKKMEG 1626
Query: 1503 EHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEP--NYEALISIQIGIMEQTIAVLDKM 1560
+ +ME++ N+ A + L R+ Q L + + + + Q + EQ +A++++
Sbjct: 1627 DLNEMEIQLNHANRMA--AEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQ-LAMVERR 1683
Query: 1561 HKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAMGSKLTCEKIV 1620
++L L + + IA +EL+ SER + + + L K
Sbjct: 1684 ANLLQAEIEELRATLEQTERSRKIA--------EQELLDASERVQLLHTQNTSLINTKKK 1735
Query: 1621 KERYENMMQQQKLTNISKQQAEQISILQ 1648
E T+IS+ Q E ILQ
Sbjct: 1736 LE-----------TDISQMQGEMEDILQ 1752
Score = 57.0 bits (136), Expect = 1e-07
Identities = 115/576 (19%), Positives = 233/576 (40%), Gaps = 82/576 (14%)
Query: 1154 TEEERKQFKDYEKKVKELNEERDKYRKSLEAE---LKKLQNSIQESTQAFDEHL------ 1204
TE+E K+ +K+K+ + + RK LE + L K +N +Q QA E L
Sbjct: 851 TEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEER 910
Query: 1205 -------KRLFERRVK--AEMVTNQEELKISNLAFSLLLDEELSSREKFLNNY---LTRK 1252
K E ++K E ++EE+ A L++E S +K +++ L +
Sbjct: 911 CDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV 970
Query: 1253 QHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKR 1312
+ EK T V+ E++ E L E K + + ++ ++ + D + L K
Sbjct: 971 EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEE-DKVNTLTKA 1029
Query: 1313 RPRISKQKTHSETTSVVPFGELPGSGKLNKD-------AFAQLMKAMDELDNISNMPEGL 1365
+ ++ +Q E G L KL D L A + + +I N + L
Sbjct: 1030 KIKLEQQVDDLE-------GSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQL 1082
Query: 1366 D-PLVWNHFCMTR-RAKVENEQ----KVKQKAADLLEMATFLQKRVEEE-------EKVQ 1412
D L F ++ ++K+E+EQ ++++K +L L++ +E E EK +
Sbjct: 1083 DEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1142
Query: 1413 QEIERVFHELILLQEE-----KVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKN 1467
++ R E+ EE + ++N + ++ + +LE L E + A L K+
Sbjct: 1143 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH 1202
Query: 1468 I---------IEDLNSVIRTQGQKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKA 1518
I++L V + ++K ME D+ + + +E L +
Sbjct: 1203 ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL 1262
Query: 1519 WDIQMLFFSRDRQKYLNE--------PNYEALISIQIGIMEQTIAVLDKMHKKNVENCKK 1570
+++ ++Q+ +N+ S Q+ E ++ L + + + ++
Sbjct: 1263 SELKSK--EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE 1320
Query: 1571 LLKKLGKFSNQKDIANYALSCN------LREELVAVSERK-DICNAMGSKLTCEKIVKER 1623
L ++L + K+ +AL + LRE+ E K ++ A+ T + +
Sbjct: 1321 LKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTK 1380
Query: 1624 YEN--MMQQQKLTNISKQQAEQISILQTEVERLRMK 1657
YE + + ++L K+ A+++ + VE + K
Sbjct: 1381 YETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAK 1416
Score = 46.6 bits (109), Expect = 2e-04
Identities = 50/217 (23%), Positives = 97/217 (44%), Gaps = 20/217 (9%)
Query: 762 HTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKE------IKQGIK 815
+TK+K TD+SQ + + D+ +E ++K+++AI + + +KE +++ K
Sbjct: 1731 NTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1790
Query: 816 SLSKTILNMMEENDKLENIA----KLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHN 871
++ +T+ ++ D+ E +A K Q+ + ELE + Q+ A+ +K + H
Sbjct: 1791 NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHE 1850
Query: 872 LAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELE----RVLQQ 927
L +E+ N + ++ K + V+++ +A EE R LQ
Sbjct: 1851 RRVKELTYQTEEDRKNILRLQDLVDK---LQAKVKSYKRQAEEAEEQSNTNLAKFRKLQH 1907
Query: 928 KKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEE 964
+ EAE R +I E+Q +K R EE
Sbjct: 1908 ELEEAE---ERADIAESQVNKLRVKSREVHTKVISEE 1941
Score = 36.6 bits (83), Expect = 0.21
Identities = 110/553 (19%), Positives = 219/553 (39%), Gaps = 87/553 (15%)
Query: 728 YQKLLISLSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQDELVLTDVKKEIPW 787
+ K+L ++ + L + K + LG++ K L Q L +K+E
Sbjct: 1455 FDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ----LETLKRENKN 1510
Query: 788 IQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLE 847
+QQ E++ +++ E + I L K + E +K E A L++ E L+ E
Sbjct: 1511 LQQ--------EISDLTEQIAEGGKRIHELEK--IKKQVEQEKCELQAALEEAEASLEHE 1560
Query: 848 E---------LERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKC 898
E L ++ E ++A+ KD E+ L ++++ I E +++ + R+
Sbjct: 1561 EGKILRIQLELNQVKSEVDRKIAE--KDEEIDQLKRNHIR--IVESMQSTLDAEIRSRN- 1615
Query: 899 FHIPCVVENFPMKARTVEELKELERVLQQ-KKIEAECLKLRKEIVEAQSGVKLIKQRHEE 957
+ +K + +L E+E L ++ AE L+ + G+ Q H +
Sbjct: 1616 -------DAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNT----QGILKDTQIHLD 1664
Query: 958 DD--EEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDI 1015
D +E+ +++ N L + L + LE R KI + LL D
Sbjct: 1665 DALRSQEDLKEQLAMVERRANLLQAEIEE--------LRATLEQTERSRKIAEQELL-DA 1715
Query: 1016 IYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERT 1075
+V+ + +K+ E + + + +I+ + E + D
Sbjct: 1716 SERVQLLHTQNTSLINTKKKLE-TDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEE 1774
Query: 1076 LVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDI 1135
L ++++ +AH + K+ + K+ L + +A + + GG +++K
Sbjct: 1775 LK-KEQDTSAHLE-----RMKKNMEQTVKDLQLRLDEAEQ-----LALKGGKKQIQK--- 1820
Query: 1136 LRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQE 1195
L + + + + E K + +E++VKEL + ++ RK++ L+ L + +Q
Sbjct: 1821 LEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNI-LRLQDLVDKLQA 1879
Query: 1196 STQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHE 1255
+++ KR E EE +NLA L EL E+ R
Sbjct: 1880 KVKSY----KRQAE---------EAEEQSNTNLAKFRKLQHELEEAEE-------RADIA 1919
Query: 1256 KSQTSEAVRKSRE 1268
+SQ ++ KSRE
Sbjct: 1920 ESQVNKLRVKSRE 1932
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 81.3 bits (199), Expect = 7e-15
Identities = 186/928 (20%), Positives = 368/928 (39%), Gaps = 140/928 (15%)
Query: 774 DELVLTDVKKE--IPWIQQKSQEAIKKEVNLFSKKRK------EIKQGIKSLSKTILNMM 825
D+L+ T ++ E I + +++++ + L +KKRK E+K+ I L T+ +
Sbjct: 912 DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 971
Query: 826 EENDKLENIAK-LDQQEFGLDLEELERLHDESQEEVAKMIKDVE-MHNLAKSYLAELIKE 883
+E EN K L ++ GLD E +AK+ K+ + + + L +L E
Sbjct: 972 KEKHATENKVKNLTEEMAGLD------------ETIAKLTKEKKALQEAHQQTLDDLQAE 1019
Query: 884 ECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKK-----IEAECLKLR 938
E + K K + +++ +LE L+Q+K +E KL
Sbjct: 1020 EDKVNTLTKA-----------------KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE 1062
Query: 939 KEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLE 998
++ AQ + I+ ++ DE+ ++ K + SNL + + + + + Q
Sbjct: 1063 GDLKLAQESIMDIENEKQQLDEKLKK--KEFEISNLQSKIEDEQALGIQLQKKIKELQAR 1120
Query: 999 LHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKE-------FEIARVKERNVRIREI 1051
+ EE+I + K ++ + E + ++ E +I K+R +++
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1180
Query: 1052 ILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQ 1111
DLE EA Q E ++ D + I + K+ + + E + I
Sbjct: 1181 RRDLE--EATLQHEATAATLRKKHA---DSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1235
Query: 1112 DASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKEL 1171
D ++ + + G + E + R + Q + + + EE+++ D + L
Sbjct: 1236 DLASNVETVSKAKGNL-----EKMCRTLEDQLSELKSKE----EEQQRLINDLTAQRGRL 1286
Query: 1172 NEERDKYRKSLEAELKKLQNSIQESTQAFD---EHLKRLFERRVKAE------------- 1215
E ++ + L+ E + L + + QAF E LKR E +KA+
Sbjct: 1287 QTESGEFSRQLD-EKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHD 1345
Query: 1216 ---MVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDV 1272
+ EE + S L + + ++ Y T + EA +K + L
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQA 1405
Query: 1273 CKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDI------LYKLFKRRPRISKQKTHSETT 1326
+EH + + A+ ++++ ++ +E+ +D+ L K++ K +
Sbjct: 1406 AEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQK 1465
Query: 1327 SVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQK 1386
EL S K + +L K + + E LD L K EN+
Sbjct: 1466 CEETHAELEASQKEARSLGTELFKIKNAYE------ESLDQL--------ETLKRENKN- 1510
Query: 1387 VKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEE---KVRFQLNLTIQILLK 1443
++Q+ +DL E KR+ E EK+++++E+ EL EE + + ++I L+
Sbjct: 1511 LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLE 1570
Query: 1444 QGQVELENFQLVLEYSDAI-LINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQIEW 1502
QV+ E + + E + I + +N I + S+ T A + D + ++E
Sbjct: 1571 LNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD----AEIRSRNDAIRLKKKMEG 1626
Query: 1503 EHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEP--NYEALISIQIGIMEQTIAVLDKM 1560
+ +ME++ N+ A + L R+ Q L + + + + Q + EQ +A++++
Sbjct: 1627 DLNEMEIQLNHANRMA--AEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQ-LAMVERR 1683
Query: 1561 HKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAMGSKLTCEKIV 1620
++L L + + IA +EL+ SER + + + L K
Sbjct: 1684 ANLLQAEIEELRATLEQTERSRKIA--------EQELLDASERVQLLHTQNTSLINTKKK 1735
Query: 1621 KERYENMMQQQKLTNISKQQAEQISILQ 1648
E T+IS+ Q E ILQ
Sbjct: 1736 LE-----------TDISQMQGEMEDILQ 1752
Score = 57.0 bits (136), Expect = 1e-07
Identities = 115/576 (19%), Positives = 233/576 (40%), Gaps = 82/576 (14%)
Query: 1154 TEEERKQFKDYEKKVKELNEERDKYRKSLEAE---LKKLQNSIQESTQAFDEHL------ 1204
TE+E K+ +K+K+ + + RK LE + L K +N +Q QA E L
Sbjct: 851 TEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEER 910
Query: 1205 -------KRLFERRVK--AEMVTNQEELKISNLAFSLLLDEELSSREKFLNNY---LTRK 1252
K E ++K E ++EE+ A L++E S +K +++ L +
Sbjct: 911 CDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV 970
Query: 1253 QHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKR 1312
+ EK T V+ E++ E L E K + + ++ ++ + D + L K
Sbjct: 971 EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEE-DKVNTLTKA 1029
Query: 1313 RPRISKQKTHSETTSVVPFGELPGSGKLNKD-------AFAQLMKAMDELDNISNMPEGL 1365
+ ++ +Q E G L KL D L A + + +I N + L
Sbjct: 1030 KIKLEQQVDDLE-------GSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQL 1082
Query: 1366 D-PLVWNHFCMTR-RAKVENEQ----KVKQKAADLLEMATFLQKRVEEE-------EKVQ 1412
D L F ++ ++K+E+EQ ++++K +L L++ +E E EK +
Sbjct: 1083 DEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1142
Query: 1413 QEIERVFHELILLQEE-----KVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKN 1467
++ R E+ EE + ++N + ++ + +LE L E + A L K+
Sbjct: 1143 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH 1202
Query: 1468 I---------IEDLNSVIRTQGQKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKA 1518
I++L V + ++K ME D+ + + +E L +
Sbjct: 1203 ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL 1262
Query: 1519 WDIQMLFFSRDRQKYLNE--------PNYEALISIQIGIMEQTIAVLDKMHKKNVENCKK 1570
+++ ++Q+ +N+ S Q+ E ++ L + + + ++
Sbjct: 1263 SELKSK--EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE 1320
Query: 1571 LLKKLGKFSNQKDIANYALSCN------LREELVAVSERK-DICNAMGSKLTCEKIVKER 1623
L ++L + K+ +AL + LRE+ E K ++ A+ T + +
Sbjct: 1321 LKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTK 1380
Query: 1624 YEN--MMQQQKLTNISKQQAEQISILQTEVERLRMK 1657
YE + + ++L K+ A+++ + VE + K
Sbjct: 1381 YETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAK 1416
Score = 46.6 bits (109), Expect = 2e-04
Identities = 50/217 (23%), Positives = 97/217 (44%), Gaps = 20/217 (9%)
Query: 762 HTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKE------IKQGIK 815
+TK+K TD+SQ + + D+ +E ++K+++AI + + +KE +++ K
Sbjct: 1731 NTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1790
Query: 816 SLSKTILNMMEENDKLENIA----KLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHN 871
++ +T+ ++ D+ E +A K Q+ + ELE + Q+ A+ +K + H
Sbjct: 1791 NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHE 1850
Query: 872 LAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELE----RVLQQ 927
L +E+ N + ++ K + V+++ +A EE R LQ
Sbjct: 1851 RRVKELTYQTEEDRKNILRLQDLVDK---LQAKVKSYKRQAEEAEEQSNTNLAKFRKLQH 1907
Query: 928 KKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEE 964
+ EAE R +I E+Q +K R EE
Sbjct: 1908 ELEEAE---ERADIAESQVNKLRVKSREVHTKVISEE 1941
Score = 36.6 bits (83), Expect = 0.21
Identities = 110/553 (19%), Positives = 219/553 (39%), Gaps = 87/553 (15%)
Query: 728 YQKLLISLSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQDELVLTDVKKEIPW 787
+ K+L ++ + L + K + LG++ K L Q L +K+E
Sbjct: 1455 FDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ----LETLKRENKN 1510
Query: 788 IQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLE 847
+QQ E++ +++ E + I L K + E +K E A L++ E L+ E
Sbjct: 1511 LQQ--------EISDLTEQIAEGGKRIHELEK--IKKQVEQEKCELQAALEEAEASLEHE 1560
Query: 848 E---------LERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKC 898
E L ++ E ++A+ KD E+ L ++++ I E +++ + R+
Sbjct: 1561 EGKILRIQLELNQVKSEVDRKIAE--KDEEIDQLKRNHIR--IVESMQSTLDAEIRSRN- 1615
Query: 899 FHIPCVVENFPMKARTVEELKELERVLQQ-KKIEAECLKLRKEIVEAQSGVKLIKQRHEE 957
+ +K + +L E+E L ++ AE L+ + G+ Q H +
Sbjct: 1616 -------DAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNT----QGILKDTQIHLD 1664
Query: 958 DD--EEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDI 1015
D +E+ +++ N L + L + LE R KI + LL D
Sbjct: 1665 DALRSQEDLKEQLAMVERRANLLQAEIEE--------LRATLEQTERSRKIAEQELL-DA 1715
Query: 1016 IYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERT 1075
+V+ + +K+ E + + + +I+ + E + D
Sbjct: 1716 SERVQLLHTQNTSLINTKKKLE-TDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEE 1774
Query: 1076 LVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDI 1135
L ++++ +AH + K+ + K+ L + +A + + GG +++K
Sbjct: 1775 LK-KEQDTSAHLE-----RMKKNMEQTVKDLQLRLDEAEQ-----LALKGGKKQIQK--- 1820
Query: 1136 LRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQE 1195
L + + + + E K + +E++VKEL + ++ RK++ L+ L + +Q
Sbjct: 1821 LEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNI-LRLQDLVDKLQA 1879
Query: 1196 STQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHE 1255
+++ KR E EE +NLA L EL E+ R
Sbjct: 1880 KVKSY----KRQAE---------EAEEQSNTNLAKFRKLQHELEEAEE-------RADIA 1919
Query: 1256 KSQTSEAVRKSRE 1268
+SQ ++ KSRE
Sbjct: 1920 ESQVNKLRVKSRE 1932
>gi|31377846 WD repeat domain 52 [Homo sapiens]
Length = 982
Score = 80.1 bits (196), Expect = 2e-14
Identities = 42/154 (27%), Positives = 77/154 (50%), Gaps = 1/154 (0%)
Query: 29 KQNVHFVNDNTICYPCGNYVIFINIETKKKTVLQCSNGI-VGVMATNIPCEVVAFSDRKL 87
+ N+ ++D+ Y GN +IF+N++TK++ L+ S+G +GV+ + +++
Sbjct: 146 RANLQLLDDSIAIYIAGNQLIFLNLKTKEQIYLRSSSGEGIGVIGVHPHKTYFTVAEKGS 205
Query: 88 KPLIYVYSFPGLTRRTKLKGNILLDYTLLSFSYCGTYLASYSSLPEFELALWNWESSIIL 147
P I +Y +P L L+ Y + F+Y G LAS S P++ L +WNW+ +
Sbjct: 206 FPDIIIYEYPSLRPYRVLRDGTEKGYAYVDFNYSGNLLASVGSNPDYTLTIWNWKEEQPI 265
Query: 148 CKKSQPGMDVNQMSFNPMNWRQLCLSSPSTVSVW 181
+ +V +++FNP QL S + W
Sbjct: 266 LRTKAFSQEVFKVTFNPDKEEQLTTSGSGHIKFW 299
Score = 40.8 bits (94), Expect = 0.011
Identities = 29/80 (36%), Positives = 41/80 (51%), Gaps = 6/80 (7%)
Query: 888 SMAVKGRALKCFHIPCVVENFPMKARTVE-ELKELERVLQQKKIEAECLKLRKEIVEAQS 946
S +K +KCFH V R +E E +E +R L++K E KL E+ E
Sbjct: 663 SYEIKDMCIKCFHFSSVKSKI---LRLIEIEKRERQRELKEKIREERRNKLAAEMGE--D 717
Query: 947 GVKLIKQRHEEDDEEEEEED 966
G K ++ EE +EEEEEE+
Sbjct: 718 GEKEFQEEEEEKEEEEEEEE 737
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 78.2 bits (191), Expect = 6e-14
Identities = 208/1025 (20%), Positives = 411/1025 (40%), Gaps = 141/1025 (13%)
Query: 729 QKLLISLSSAMDKENHYLSTTP-KVSVDLGSDSEHTKQKASTD------------LSQDE 775
++L++ L +++ Y S KV+ G E K+K D LS+D+
Sbjct: 621 ERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDK 680
Query: 776 LVLTDVKKEI-----PWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDK 830
VL+ K + +K Q + EV L K+ +K+ I L K + M+EE D
Sbjct: 681 EVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDN 740
Query: 831 LENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSY---LAELIKEECWN 887
L + + +Q + +L E EV++ ++ ++ N+ ++ LA++ +E+C
Sbjct: 741 LNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNL 800
Query: 888 SMAVKGRALKC-FHIPCVVENFPMKARTVEELKELERVLQQKKI--EAECLKLRKEIVEA 944
+ + L+ I C+ E ++ EELK L R +Q+K+ E +++ E
Sbjct: 801 AFQRDEKVLELEKEIKCLQEESVVQC---EELKSLLRDYEQEKVLLRKELEEIQSEKEAL 857
Query: 945 QSGVKLIKQRHEEDDEEE-------EEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQL 997
QS + +K +E+ E EE +T S + N F + L L
Sbjct: 858 QSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHN----EKEKCFIKEHENLKPLL 913
Query: 998 ELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLEL 1057
E ++ ++ILLKD + K +V N+ ++ K+ E +I +++ E I ++L
Sbjct: 914 EQKELRDRRAELILLKDSLAKSPSVKNDPL-SSVKELEEKIENLEKECKEKEEKINKIKL 972
Query: 1058 EEAVWQPEFEDCEKPERTLVVQDEEITAHKH---------IKPWHKAKELIVNHEKEHWL 1108
+ E + K +T+ + E + + K I+ K L++ +EK+
Sbjct: 973 VAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQ 1032
Query: 1109 L-------------IQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTE 1155
L I+D + +LR + + ED+L + E
Sbjct: 1033 LDVEKERANNFEHRIEDLTRQLRN-STLQCETINSDNEDLLARI---------------E 1076
Query: 1156 EERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFD--EHLKRLFERRVK 1213
+ K E ++ E+ + K LEAE + + I+E + E L+ ++ K
Sbjct: 1077 TLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKK 1136
Query: 1214 AEMVTNQE-ELKISNLAFSLLLDEELSSRE---KFLNNYLTRKQHE----------KSQT 1259
T QE EL + + L++ E++ E K LN LT K ++ + Q
Sbjct: 1137 QLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQK 1196
Query: 1260 SEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVD--ILYKLFKRRPRIS 1317
E +++ L + Y+ + K + KKE ++ + D IL K S
Sbjct: 1197 QETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEAS 1256
Query: 1318 KQKTH------SETTSVVP--FGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLV 1369
+Q+ +E TS L S + ++ + + + L + V
Sbjct: 1257 QQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATV 1316
Query: 1370 WNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHEL-ILLQEE 1428
+ F KV +KQ+ + + Q E ++ ++ +E + +L I LQ+
Sbjct: 1317 TSEF---ESYKVRVHNVLKQQ-----KNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDS 1368
Query: 1429 KVRFQLNLT-IQILLKQGQVELENFQLVLEYS---DAILINKNI-IEDLNSVIRTQGQKK 1483
+ Q+N++ +Q L + LE +L+ + +A L K I+ N +++++ +
Sbjct: 1369 QNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQT 1428
Query: 1484 VASMMESKDVHKRILQIEWEHKKMEMER--EDLNQKAWDIQMLFFSRDRQKYLNEPNYEA 1541
V+ + +V + + + H + E + E L Q+ ++ F + NEP +
Sbjct: 1429 VSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLF-----QLKNEPTTRS 1483
Query: 1542 LISIQIGI-----MEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREE 1596
+S Q + T L MH E + + + ++ + +++ + E+
Sbjct: 1484 PVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGM-----ETTDTESVSSASTYTQSLEQ 1538
Query: 1597 LVAVSERKDICNAMGSKLTCEKIVKERYENMMQQQKLTNISKQQ-------AEQISILQT 1649
L+ E K ++ T E++V++ L + ++ EQI +L++
Sbjct: 1539 LLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKS 1598
Query: 1650 EVERL 1654
E+ RL
Sbjct: 1599 EIRRL 1603
Score = 73.2 bits (178), Expect = 2e-12
Identities = 203/1001 (20%), Positives = 399/1001 (39%), Gaps = 130/1001 (12%)
Query: 738 AMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEA-- 795
++ KEN + + SV D+ +++ + ++ + ++K E+ ++ K E
Sbjct: 94 SLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKE---IENLKNELMAVRSKYSEDKA 150
Query: 796 -IKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEELERLHD 854
++K++ + E+ + +K + + N+ + +++E I +++ ++L+ D
Sbjct: 151 NLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTD 210
Query: 855 ESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKART 914
E +E V ++ +E ++ ++EE A+ +K + C +E +
Sbjct: 211 EKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVK--ELMCQIEASAKEHEA 268
Query: 915 -VEELKELERVLQ----------QKKIEAECLKLRKEIVEAQSGVKLI------------ 951
+ +L EL+ L QKK E E LRK A ++
Sbjct: 269 EINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQ 328
Query: 952 ----KQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREE--- 1004
K +H ED +E E ++ + + +L +D + + H RE+
Sbjct: 329 VVNEKVKHLEDTLKELESQHSILKDEVT--YMNNLKLKLEMDAQHIKDEF-FHEREDLEF 385
Query: 1005 KINQIILLKD----IIYKVKTV---FNNEFDAAYKQKEFEIARVKERNVRIREIILDLEL 1057
KIN+++L K+ +I K+K+ N +F +Q E+ +KE++ +EI EL
Sbjct: 386 KINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQ--KEI---SEL 440
Query: 1058 EEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHE--KEHWLLIQ---- 1111
E D EK + TL+ + + + K +E I+N+E +E ++Q
Sbjct: 441 NETF----LSDSEKEKLTLMFEIQGLKEQCENLQQEK-QEAILNYESLREIMEILQTELG 495
Query: 1112 ----DASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEER-----KQFK 1162
S ++ + ++ + + A + + + E E+ +
Sbjct: 496 ESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVP 555
Query: 1163 DYEKKVKELNEERDKYRKSL---EAELKKLQ---NSIQESTQAFDEHLKRLFERRVKAEM 1216
+ E +K L E+ Y SL + LK+L+ NS+ E F LK E
Sbjct: 556 ELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHK 615
Query: 1217 VTNQEELKISNLA----FSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDV 1272
+EE I L ++ + EL + L L EK Q + + K + V
Sbjct: 616 KCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKV 675
Query: 1273 CKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQK-THSETTSVVPF 1331
E + L AE K + K SE D+ L ++ I K+ T E +
Sbjct: 676 LSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMV 735
Query: 1332 GELPGSGKLNKDAFAQLMKAMDEL--------DNISNMPEGLDPLVWNHFCMTRRAKVEN 1383
E KL ++ Q + +L +S E D + AK+ N
Sbjct: 736 EEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKI-N 794
Query: 1384 EQKVK---QKAADLLEMATFLQKRVEEEEKVQ-QEIERVFHELILLQEEKVRFQLNLTIQ 1439
E+K Q+ +LE+ + K ++EE VQ +E++ + + ++EKV +
Sbjct: 795 EEKCNLAFQRDEKVLELEKEI-KCLQEESVVQCEELKSLLRD---YEQEKVLLRKE---- 846
Query: 1440 ILLKQGQVELENFQL-VLEYSDAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRIL 1498
L++ Q E E Q +LE +A K +E+ N +I+ + + S E + ++
Sbjct: 847 --LEEIQSEKEALQSDLLEMKNA--NEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCF 902
Query: 1499 QIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLD 1558
E E+ K +E+++L + ++ +L + P+ + + +E+ I L+
Sbjct: 903 IKEHENLKPLLEQKELRDRRAELILL-----KDSLAKSPSVKNDPLSSVKELEEKIENLE 957
Query: 1559 KMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAMGSKLTCEK 1618
K K+ E K+ K + D + ++EEL ++ KD +A L
Sbjct: 958 KECKEKEEKINKIKLVAVKAKKELDSSRKETQ-TVKEELESLRSEKDQLSASMRDLIQG- 1015
Query: 1619 IVKERYENMMQQQKLTNISKQQAEQISILQTEVERLRMKTF 1659
E Y+N++ + ++Q+EQ+ +VE+ R F
Sbjct: 1016 --AESYKNLLLEY------EKQSEQL-----DVEKERANNF 1043
Score = 62.0 bits (149), Expect = 5e-09
Identities = 158/816 (19%), Positives = 330/816 (40%), Gaps = 123/816 (15%)
Query: 879 ELIKEECWNSMAVKGRALKCFHIPCVVENF---PMKARTVEELKELER-----VLQQKKI 930
+LIK M ++ +C + +E P+ T + +K L +L++ +
Sbjct: 29 DLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAET 88
Query: 931 EAECLKLRKEIV----EAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDF 986
E +CL L+KE + E + V + H+E ++ K ++ NL N L+ ++ + +
Sbjct: 89 EQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIE--NLKNELM-AVRSKY 145
Query: 987 GVDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNV 1046
D + L QL EE +N + L + + F N + K+ + EI +++
Sbjct: 146 SEDKANLQKQL-----EEAMNTQLELSE-----QLKFQNNSEDNVKKLQEEIEKIR---- 191
Query: 1047 RIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEH 1106
P FE E+ L +Q + K + I+ +H
Sbjct: 192 -----------------PGFE-----EQILYLQKQLDATTDEKKETVTQLQNIIEANSQH 229
Query: 1107 WLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEK 1166
+ + +L + + + + +E++ ++ A + +A E K + E
Sbjct: 230 Y------QKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEA----EINKLNELKEN 279
Query: 1167 KVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTN------Q 1220
VK+ +K E EL+ L+ + + Q ++ L + E V N +
Sbjct: 280 LVKQCEASEKNIQKKYECELENLRKATSNANQD-NQICSILLQENTFVEQVVNEKVKHLE 338
Query: 1221 EELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNL 1280
+ LK S+L DE ++NN + + + + REDL+ + L
Sbjct: 339 DTLKELESQHSILKDE-----VTYMNNLKLKLEMDAQHIKDEFFHEREDLEF---KINEL 390
Query: 1281 LAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRI-SKQKTHSETTSVVPFGELPGSGK 1339
L + +K SE+ G Y + + + S ++ H + S + L S K
Sbjct: 391 LLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEK 450
Query: 1340 LNKDAFAQLMKAMDELDNI-----------SNMPEGLDPLVWNHFCMTRRAKVENEQKVK 1388
++ ++ +N+ ++ E ++ L + E E +
Sbjct: 451 EKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQ 510
Query: 1389 QKAADLLEMATFLQKRVEEEEKVQQEIERV--FHELILLQEEKVRFQLNLTIQILLKQGQ 1446
Q+A+D+ E+ L+ E++ + + + R+ +E +L Q+E V +L TI+ L ++
Sbjct: 511 QQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVP-ELENTIKNLQEKNG 569
Query: 1447 VELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQIEWEHKK 1506
V L L L D +L ++L I + ++K + + K+ H+ +++ HKK
Sbjct: 570 VYL----LSLSQRDTML------KELEGKINSLTEEKDDFINKLKNSHE---EMDNFHKK 616
Query: 1507 MEMERE---DLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDKMHKK 1563
E E +L +K Q + ++ + ++ +NE G +E+T+ K +
Sbjct: 617 CEREERLILELGKKV--EQTIQYNSELEQKVNE---------LTGGLEETL----KEKDQ 661
Query: 1564 NVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAMGSKLTCEKIVKER 1623
N + +KL+ ++ S K++ + + E SE+K + + L+ ++ V +
Sbjct: 662 NDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILK 721
Query: 1624 YENMMQQQKLTNISKQQAEQISILQTE-VERLRMKT 1658
++KL + ++Q +L+ E V++L +KT
Sbjct: 722 EHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKT 757
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 78.2 bits (191), Expect = 6e-14
Identities = 121/590 (20%), Positives = 238/590 (40%), Gaps = 53/590 (8%)
Query: 735 LSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQE 794
L ++E + +V S+ + K TD Q L + KK++ Q+++E
Sbjct: 1343 LREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEE 1402
Query: 795 AIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEELERLHD 854
A++ VN ++ K +++ + ++ +E ++ Q+ F L E ++ ++
Sbjct: 1403 AVEA-VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE 1461
Query: 855 ESQEEVAKMIKDVEMHNLAKSYLAELIK-----EECWNSMAVKGRALKCFH--IPCVVEN 907
ESQ E+ K+ A+S EL K EE + R K I + E
Sbjct: 1462 ESQSELESSQKE------ARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1515
Query: 908 FPMKARTVEELKELERVLQQKKIEAECLKLRKE---------IVEAQSGVKLIKQRHEED 958
+T+ EL+++ + L+ +K+E + E I+ AQ IK E
Sbjct: 1516 LGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERK 1575
Query: 959 DEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREE-KINQIILLKDIIY 1017
E++EE + K ++L ++ SL T +T + L + + E +N++ +
Sbjct: 1576 LAEKDEEMEQAKRNHLR--VVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN 1633
Query: 1018 KVKTVFNNE---FDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDC----E 1070
++ + + K + ++ N ++E I +E + Q E E+ E
Sbjct: 1634 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1693
Query: 1071 KPERTLVVQDEE-ITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLE 1129
+ ER+ + ++E I + ++ H ++N +K+ + T + + E
Sbjct: 1694 QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEE 1753
Query: 1130 VKKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERD-----------KY 1178
K+ I + + D E K K+ E+ +K+L D K
Sbjct: 1754 KAKKAITDAAMMAEELKKEQDTSAHLERMK--KNMEQTIKDLQHRLDEAEQIALKGGKKQ 1811
Query: 1179 RKSLEAELKKLQNSIQESTQAFDEHLK--RLFERRVKAEMVTNQEELKISNLAFSLLLDE 1236
+ LEA +++L+N ++ + E +K R ERR+K +T Q E NL L +
Sbjct: 1812 LQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKE--LTYQTEEDRKNLLRLQDLVD 1869
Query: 1237 ELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKV 1286
+L + K + + + RK + +LD +E D +AE +V
Sbjct: 1870 KLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERAD--IAESQV 1917
Score = 59.7 bits (143), Expect = 2e-08
Identities = 179/930 (19%), Positives = 374/930 (40%), Gaps = 144/930 (15%)
Query: 774 DELVLTDVKKEIPWIQQKSQEAIKKEVN--LFSKKRK------EIKQGIKSLSKTILNMM 825
D+L+ ++ E + + ++E+N L +KKRK E+K+ I L T+ +
Sbjct: 906 DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVE 965
Query: 826 EENDKLENIAK-LDQQEFGLDLEELERLHDESQEEVAKMIKDVE-MHNLAKSYLAELIKE 883
+E EN K L ++ GLD E +AK+ K+ + + + L +L E
Sbjct: 966 KEKHATENKVKNLTEEMAGLD------------EIIAKLTKEKKALQEAHQQALDDLQAE 1013
Query: 884 ECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQ-KKIEAECLKLRKEIV 942
E + K K + +++ +LE L+Q KK+ + + ++++
Sbjct: 1014 EDKVNTLTKA-----------------KVKLEQQVDDLEGSLEQEKKVRMDLERAKRKL- 1055
Query: 943 EAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLP-NYLLGSLSTDFGVDTSLLSSQLELHS 1001
+ +KL ++ + + ++++ D+ +K + N L + + + + L EL +
Sbjct: 1056 --EGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 1113
Query: 1002 REEKINQII----LLKDIIYKVKTVFNNEFDAAYKQKE-------FEIARVKERNVRIRE 1050
R E++ + + + + K+++ + E + ++ E +I K+R ++
Sbjct: 1114 RIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQK 1173
Query: 1051 IILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLI 1110
+ DLE EA Q E ++ D + I + K+ + + E L +
Sbjct: 1174 MRRDLE--EATLQHEATAAALRKKHA---DSVAELGEQIDNLQRVKQKLEKEKSEFKLEL 1228
Query: 1111 QDASTRL------RALMDMMGGVLE-------VKKEDILRMVIPQPAFMAKPDAVWTE-- 1155
D ++ + +A ++ M LE K E+ R V + AK + TE
Sbjct: 1229 DDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAK---LQTENG 1285
Query: 1156 EERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAE 1215
E +Q + E + +L + Y + LE L+ ++E +A + L R +
Sbjct: 1286 ELSRQLDEKEALISQLTRGKLTYTQQLE----DLKRQLEEEVKAKNALAHALQSARHDCD 1341
Query: 1216 MVTNQ-EELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCK 1274
++ Q EE + +L + S ++ Y T + EA +K + L +
Sbjct: 1342 LLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1401
Query: 1275 EHYDNLLAEDKVMDRSFKKEFSEIPGHQVDI------LYKLFKRRPRISKQKTHSETTSV 1328
E + + A+ ++++ + +EI VD+ L K++ K +
Sbjct: 1402 EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE 1461
Query: 1329 VPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQKVK 1388
EL S K + +L K + + E L+ L K EN+ ++
Sbjct: 1462 ESQSELESSQKEARSLSTELFKLKNAYE------ESLEHL--------ETFKRENKN-LQ 1506
Query: 1389 QKAADLLEMATFLQKRVEEEEKVQQEIERVFHEL-ILLQEEKVRFQLN----LTIQILLK 1443
++ +DL E K + E EKV++++E EL L+E + + L Q+
Sbjct: 1507 EEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFN 1566
Query: 1444 QGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQIEWE 1503
Q + E+E +L + + +N + ++S ++T + S E+ V K+ +E +
Sbjct: 1567 QIKAEIER-KLAEKDEEMEQAKRNHLRVVDS-LQTSLDAETRSRNEALRVKKK---MEGD 1621
Query: 1504 HKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIG-IMEQTIAVLDKMHK 1562
+ME++ N+ A + Q + Q L + + +++ +++ IA++++ +
Sbjct: 1622 LNEMEIQLSHANRMAAEAQKQV--KSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNN 1679
Query: 1563 KNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAMGSKLTCEKIVKE 1622
++L + + + +A +EL+ SER + ++
Sbjct: 1680 LLQAELEELRAVVEQTERSRKLA--------EQELIETSERVQLLHS------------- 1718
Query: 1623 RYENMMQQQKLTNISKQQAEQISILQTEVE 1652
Q L N K+ +S LQTEVE
Sbjct: 1719 ------QNTSLINQKKKMDADLSQLQTEVE 1742
Score = 53.5 bits (127), Expect = 2e-06
Identities = 113/561 (20%), Positives = 234/561 (41%), Gaps = 72/561 (12%)
Query: 1155 EEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKA 1214
E+ + K+ E+K+ L +E++ + ++AE Q+++ ++ + D+ +K + K
Sbjct: 864 EKSEARRKELEEKMVSLLQEKNDLQLQVQAE----QDNLADAEERCDQLIKNKIQLEAKV 919
Query: 1215 ----EMVTNQEELKISNLAFSLLLDEELSSREKFLNNY---LTRKQHEKSQTSEAVRKSR 1267
E + ++EE+ A L++E S ++ +++ L + + EK T V+
Sbjct: 920 KEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLT 979
Query: 1268 EDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTHSETTS 1327
E++ E L E K + + ++ ++ + D + L K + ++ +Q E
Sbjct: 980 EEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEE-DKVNTLTKAKVKLEQQVDDLE--- 1035
Query: 1328 VVPFGELPGSGKLNKD-------AFAQLMKAMDELDNISNMPEGLDP-LVWNHFCMTR-R 1378
G L K+ D L + + ++ N + LD L F +
Sbjct: 1036 ----GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALN 1091
Query: 1379 AKVENEQ----KVKQKAADLLEMATFLQKRVEEE-------EKVQQEIERVFHELILLQE 1427
A++E+EQ ++++K +L L++ +E E EK++ ++ R E+ E
Sbjct: 1092 ARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE 1151
Query: 1428 E-----KVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKNI---------IEDLN 1473
E V+ ++N + ++ + +LE L E + A L K+ I++L
Sbjct: 1152 EAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQ 1211
Query: 1474 SVIRTQGQKKVASMMESKDVHKRILQI-------EWEHKKMEMEREDLNQKAWDIQMLFF 1526
V + ++K +E DV + QI E + +E + + KA + Q
Sbjct: 1212 RVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN 1271
Query: 1527 SRDRQK-YLNEPNYEALISIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQKDIA 1585
Q+ L N E +S Q+ E I+ L + + + L ++L + K+
Sbjct: 1272 DLTSQRAKLQTENGE--LSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNAL 1329
Query: 1586 NYAL-----SCN-LREELVAVSERKDICNAMGSKLTCEKIV-KERYEN--MMQQQKLTNI 1636
+AL C+ LRE+ +E K + SK E + +YE + + ++L
Sbjct: 1330 AHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEA 1389
Query: 1637 SKQQAEQISILQTEVERLRMK 1657
K+ A+++ + VE + K
Sbjct: 1390 KKKLAQRLQEAEEAVEAVNAK 1410
Score = 45.4 bits (106), Expect = 4e-04
Identities = 142/777 (18%), Positives = 310/777 (39%), Gaps = 104/777 (13%)
Query: 765 QKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNM 824
+K +DLS++ +++ +E E KK F K R+++++ T +
Sbjct: 1133 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1192
Query: 825 MEENDKLENIAKLDQQEFGLDL--EELERLHDESQEEVAKMIKDVEMHNLAKSYLAELIK 882
+++ +++A+L +Q L ++LE+ E + E+ + ++E AK+ L ++ +
Sbjct: 1193 RKKH--ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCR 1250
Query: 883 --EECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKI---------- 930
E+ N K + V + +A+ E EL R L +K+
Sbjct: 1251 TLEDQMNEHRSKAEETQ----RSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKL 1306
Query: 931 ----EAECLKLRKE------------IVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNL 974
+ E LK + E + A+ L+++++EE+ E + E + + +N
Sbjct: 1307 TYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANS 1366
Query: 975 PNYLLGSLSTDFGVDTSLLSSQLE---------LHSREEKINQIILLKDIIYKVKTVFNN 1025
+ T + D + +LE L EE + + + K K N
Sbjct: 1367 E---VAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQN 1423
Query: 1026 EFD---AAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEE 1082
E + ++ A + ++ +I+ + + + Q E E +K R+L +
Sbjct: 1424 EIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTE--- 1480
Query: 1083 ITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRAL---------MDMMGGVLEVKKE 1133
K + ++ E + ++E+ L ++ S L ++ + LE +K
Sbjct: 1481 --LFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKM 1538
Query: 1134 DILRMVIPQPAFMAKPDA--VWTEEERKQFK-DYEKKVKELNEERDKYRKSLEAELKKLQ 1190
++ + A + + + + E Q K + E+K+ E +EE ++ +++ + LQ
Sbjct: 1539 ELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQ 1598
Query: 1191 NSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNYLT 1250
S+ T++ +E L RVK +M + E++I L+ + + E + K L + L
Sbjct: 1599 TSLDAETRSRNEAL------RVKKKMEGDLNEMEIQ-LSHANRMAAEAQKQVKSLQSLLK 1651
Query: 1251 RKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVM-------DRSFKKEFSEI--PGH 1301
Q + A +E++ + + + L AE + + +RS K E+
Sbjct: 1652 DTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE 1711
Query: 1302 QVDILYK----LFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFA-------QLMK 1350
+V +L+ L ++ ++ + +T E + + K A +L K
Sbjct: 1712 RVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKK 1771
Query: 1351 AMDELDNISNMPEGLDPLVWNHFCMTRRAKV-------ENEQKVKQKAADLLEMATFLQK 1403
D ++ M + ++ + + A+ + QK++ + +L QK
Sbjct: 1772 EQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQK 1831
Query: 1404 RVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTIQILLKQGQVELENFQLVLEYSD 1460
R E K ++ ER EL EE + L L Q L+ + Q++++ ++ E ++
Sbjct: 1832 RNAESVKGMRKSERRIKELTYQTEEDRKNLLRL--QDLVDKLQLKVKAYKRQAEEAE 1886
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 77.4 bits (189), Expect = 1e-13
Identities = 172/854 (20%), Positives = 363/854 (42%), Gaps = 145/854 (16%)
Query: 777 VLTDVKKEIPWIQQKS---QEAIKKEVN-LFSKKRKEIKQGIKSLSKTILNMMEENDKL- 831
V ++ EI ++Q++ ++A+ N L SK+ E+ + + ++ + + E+ KL
Sbjct: 411 VREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQ 470
Query: 832 -ENIAKLDQQEFG----LDLEELERLHDESQEEVAKMI-------KDVEMHNLAKSYLAE 879
E + K + ++ + L+E ER +E Q + K +D++ +AK +
Sbjct: 471 QEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQ 530
Query: 880 LIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELK-ELERVLQQKK-IEAECLKL 937
+ + +++ K + + + ++E+ + E L+ +++ +L+Q + ++A+ +
Sbjct: 531 SLHSKLTDTLVSKQQLEQ--RLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQF 588
Query: 938 RKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQL 997
+I S L ++ H+ E+DK +K + + SL S +
Sbjct: 589 HSQIAAQTSASVLAEELHKVI----AEKDKQIKQT----------------EDSLASERD 628
Query: 998 ELHSREEKINQI----ILLKDIIYKVKTVFNNEFDAAYK-QKEFEIARVKERNVRIREII 1052
L S+EE++ I LLK + K++ + N + AA++ +K + VK+ +R+ E
Sbjct: 629 RLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQ 688
Query: 1053 LDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQD 1112
L E+ + EF+ + L + +++ +P K+++ EK IQ+
Sbjct: 689 LQHEISNKM--EEFKILNDQNKALKSEVQKLQTLVSEQP---NKDVVEQMEK----CIQE 739
Query: 1113 ASTRLRALMDMMG-GVLEVK-KEDILRMVIPQPAFMAKP--DAVWTEEERKQFKDYEKKV 1168
+L+ + +++ G+++V KE+ L + + + + K D + ++ F +++
Sbjct: 740 KDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEEL 799
Query: 1169 KELNEERDKYRKS----LEAELKKLQN-------SIQESTQAFDEHLKRLFERRVKAEMV 1217
K++ E+D KS LEAEL K+ N SI Q LK E+ + V
Sbjct: 800 KKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAV 859
Query: 1218 TNQEELKISNLAFSLL-LDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEH 1276
++E ++N L L EE S + + E S S+ E+L++ +
Sbjct: 860 LEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQF-----EELEIVLKE 914
Query: 1277 YDNLLAEDKVMDRSFKKEFSEIPGHQVDIL--YKLFKRRPRISKQKTHSETTSVVPFGEL 1334
+N L + M + + + S D+ KLFK + KQ+ + + +S P EL
Sbjct: 915 KENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEEL 974
Query: 1335 PGSGKLNKDAFAQLMKAMDELDNISNMPE---------------------GLDPLVWNHF 1373
K+ + ++ +ELD++ + E + ++ +
Sbjct: 975 L---KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKV 1031
Query: 1374 CMTRRAKVENEQKVKQKAADLL----------------EMATFLQKRVEE---------- 1407
T + + + + V+ +A ++L E +K+ +E
Sbjct: 1032 NKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEE 1091
Query: 1408 ----EEKVQQEIERVFHELILLQEEKVRFQLNLTIQILLK-QGQVELENFQLVLEYSDAI 1462
E K+++ E H L+ L+ EK + L T IL K Q VE E + ++ ++
Sbjct: 1092 VKVLEHKLKEADE--MHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDES- 1148
Query: 1463 LINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQ 1522
I+ + S + Q+ E+KD+ L+ E EH +ME+E+ ++ + + +
Sbjct: 1149 ---HKTIKQMQSSFTSSEQELERLRSENKDIEN--LRREREHLEMELEKAEMERSTYVTE 1203
Query: 1523 MLFFSRDRQKYLNE 1536
+ R+ + LNE
Sbjct: 1204 V----RELKAQLNE 1213
Score = 52.8 bits (125), Expect = 3e-06
Identities = 155/767 (20%), Positives = 299/767 (38%), Gaps = 173/767 (22%)
Query: 998 ELHSREEKINQIIL-LKDII---YKVKTVFNNEFDAAYK--------------QKEFEIA 1039
E+ + +E+ N +I +KD I K VF N+ +Y+ Q E EIA
Sbjct: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
Query: 1040 RVKERNVRIREIILDL------------------------ELEEAVWQPEFEDCEKPERT 1075
+K+ N +R+ + + EL E + + E+ +K
Sbjct: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
Query: 1076 LVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDI 1135
++ + + W + + I EH QD ++ A + + L K D
Sbjct: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQS-LHSKLTDT 539
Query: 1136 LRMVIPQPAFMAKPDAVWTEEER-KQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSI- 1193
L V Q + +E++R + + + +V+++ E+ + +L+A++++ + I
Sbjct: 540 L--VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNE----ALKAQIQQFHSQIA 593
Query: 1194 -QESTQAFDEHLKRLFERRVKA-------------EMVTNQEELK-ISNLAFSLLLDEEL 1238
Q S E L ++ + K + + +EELK I N+ F LL E+
Sbjct: 594 AQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNF--LLKAEV 651
Query: 1239 SSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEI 1298
+ N E++ + + K ++ + V K+ LL E + S K E
Sbjct: 652 QKLQALAN--------EQAAAAHELEKMQQSVYV-KDDKIRLLEEQLQHEISNKMEE--- 699
Query: 1299 PGHQVDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDN- 1357
+K+ + + K + T V S + NKD Q+ K + E D
Sbjct: 700 --------FKILNDQNKALKSEVQKLQTLV--------SEQPNKDVVEQMEKCIQEKDEK 743
Query: 1358 --------------ISNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQ- 1402
++ E L+ + + +T+ Q +K K D + A+ ++
Sbjct: 744 LKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV-----QDLKAKQNDQVSFASLVEE 798
Query: 1403 -KRV--EEEEKVQQEIERVFHELILLQEEKVRFQLNLT-----IQILLKQGQVELENFQL 1454
K+V E++ K++ E + EL+ + ++ QL++T +Q LLK + ++ +
Sbjct: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKA 858
Query: 1455 VLEYSDAILINKNI----IEDLNSVIRTQGQ-------KKVASMMESKDVHKRILQIEWE 1503
VLE + L N +++ N ++ Q K+ +S + +++ + + E E
Sbjct: 859 VLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENE 918
Query: 1504 HKKMEM---ERED-------LNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQT 1553
K++E ERE L Q D LF S+ Q L + NY+ S E+
Sbjct: 919 LKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQ--LKQQNYQQASSFPPH--EEL 974
Query: 1554 IAVLDKMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAMGSK 1613
+ V+ E K++ + + KD + N +L R+ AM +
Sbjct: 975 LKVIS-------EREKEISGLWNELDSLKDAVEHQRKKN--NDL-----REKNWEAMEAL 1020
Query: 1614 LTCEKIVKERYENMMQQQKLTNISKQQAEQISILQTEVERLRMKTFP 1660
+ EK M Q K+ SK++ +Q+ ++ E + + K FP
Sbjct: 1021 ASTEK---------MLQDKVNKTSKERQQQVEAVELEAKEVLKKLFP 1058
Score = 48.5 bits (114), Expect = 5e-05
Identities = 151/779 (19%), Positives = 325/779 (41%), Gaps = 112/779 (14%)
Query: 722 SEILDYYQKLLISLSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQDELVLTDV 781
+E+ + KL +L S E + + + E + + L Q+E + +
Sbjct: 527 NEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKE-ESLQMQVQDILEQNEALKAQI 585
Query: 782 KKEIPWIQ-QKSQEAIKKEVN-LFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQ 839
++ I Q S + +E++ + ++K K+IKQ SL+ + + ++L++I ++
Sbjct: 586 QQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNF 645
Query: 840 QEFGLDLEELERLHDE---SQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAV----- 891
++++L+ L +E + E+ KM + V + + L E ++ E N M
Sbjct: 646 L-LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILN 704
Query: 892 -KGRALKCF--HIPCVVENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGV 948
+ +ALK + +V P K + ++++E+ +Q+K E LK +E++E +G+
Sbjct: 705 DQNKALKSEVQKLQTLVSEQPNK----DVVEQMEKCIQEKD---EKLKTVEELLE--TGL 755
Query: 949 KLIKQRHEE---------------DDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTS-- 991
+ + EE D + ++ D+ V +++L L + G S
Sbjct: 756 IQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQ-VSFASLVEELKKVIHEKDGKIKSVE 814
Query: 992 -LLSSQLELHSREEKINQIILLKDI-----IYKVKTVFNNEFDAAYKQKEFEIAR----- 1040
LL ++L + +EK Q+ + + + K K N A ++KE ++A
Sbjct: 815 ELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWL 874
Query: 1041 --VKERNVRIREIILDL---ELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKA 1095
++E N ++ + ++ L+EA +FE+ E +V E+ K ++ K
Sbjct: 875 QDLQEENESLKAHVQEVAQHNLKEASSASQFEELE------IVLKEKENELKRLEAMLKE 928
Query: 1096 KELIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTE 1155
+E ++ + + +QD + ++ ++ ++K+++ Q A P E
Sbjct: 929 RESDLSSKTQLLQDVQDENKLFKSQIE------QLKQQNY------QQASSFPPH----E 972
Query: 1156 EERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAF-----------DEHL 1204
E K + EK++ L E D + ++E + KK + +++ +A D+
Sbjct: 973 ELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVN 1032
Query: 1205 KRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTS--EA 1262
K ER+ + E V + + + L + + LS E +L+ + + + + TS E
Sbjct: 1033 KTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGE-WLHGFEKKAKECMAGTSGSEE 1091
Query: 1263 VRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTH 1322
V+ L E + L E + +K +E G IL KL + + +
Sbjct: 1092 VKVLEHKLKEADEMHTLLQLECE----KYKSVLAETEG----ILQKLQRSVEQEENKWKV 1143
Query: 1323 SETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVE 1382
S ++ S ++ +L +++N+ E L+ + +A++E
Sbjct: 1144 KVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMEL-------EKAEME 1196
Query: 1383 NEQ---KVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTI 1438
+V++ A L E T L+ E +KV ++ + L L+Q + V+ + T+
Sbjct: 1197 RSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTV 1255
Score = 43.9 bits (102), Expect = 0.001
Identities = 156/838 (18%), Positives = 338/838 (40%), Gaps = 151/838 (18%)
Query: 906 ENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEE 965
E P+ T +E ++ KK + E + + + ++ A + + L+ ++ E
Sbjct: 192 EALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREV 251
Query: 966 DKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNN 1025
+K P+ + G S +L + +K N + KD + +KT+ +
Sbjct: 252 IDLLK----PDQVEGIQK----------SGTKKLKTETDKENAEVKFKDFLLSLKTMMFS 297
Query: 1026 EFDA-----AYKQKE--FEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVV 1078
E +A K+K + A K + +I L+ ++ + ED +
Sbjct: 298 EDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQ 357
Query: 1079 QDEEITAHKHIK--PWHKAKELIVNHEKEH----------WLLIQDASTRLRALMDMM-G 1125
+E+ K + K+ I EKEH + Q + + + + M
Sbjct: 358 LTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEA 417
Query: 1126 GVLEVKKED-ILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDK------Y 1178
+ +K+E+ ILR + + ++ + E K +DY + V EL E+ K
Sbjct: 418 EIAHLKQENGILRDAVSNTT--NQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQ 475
Query: 1179 RKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEEL 1238
+K+ E +L+ +QE+ + ++E + + R+ AE Q++L+ +A +E
Sbjct: 476 KKNAEQAATQLKVQLQEAERRWEE--VQSYIRKRTAEHEAAQQDLQSKFVAKE---NEVQ 530
Query: 1239 SSREKFLNNYLTRKQHEK--SQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFS 1296
S K + ++++Q E+ Q E+ +K + + ++L +++ + ++ S
Sbjct: 531 SLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHS 590
Query: 1297 EIPGHQ-----VDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKA 1351
+I + L+K+ + + KQ S + +D +L
Sbjct: 591 QIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLAS--------------ERD---RLTSK 633
Query: 1352 MDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQKV-KQKAADLLEMATFLQKRVEEEEK 1410
+EL +I NM +F + +A+V+ Q + ++AA E+ Q +++K
Sbjct: 634 EEELKDIQNM----------NFLL--KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK 681
Query: 1411 VQQEIERVFHELILLQEEKVRFQLNLTIQILLKQGQV---ELENFQLVLEYSDAILINKN 1467
++ E++ HE+ EE +IL Q + E++ Q ++ NK+
Sbjct: 682 IRLLEEQLQHEISNKMEE---------FKILNDQNKALKSEVQKLQTLVSEQP----NKD 728
Query: 1468 IIEDLNSVIRTQGQ--KKVASMMESKDV-----HKRILQIEWEHKKMEMEREDLNQKAWD 1520
++E + I+ + + K V ++E+ + + + I E+ + E +DL K D
Sbjct: 729 VVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND 788
Query: 1521 IQMLFFS--RDRQKYLNE-------------------PNYEALISIQIGIMEQTIAVLDK 1559
Q+ F S + +K ++E N E + + I Q + L K
Sbjct: 789 -QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLK 847
Query: 1560 MHKKNVENCKKLLKK-------LGKFSNQKDIANYALSCNLREELVAVSERKDICNAMGS 1612
++ + K +L++ GK+ N +L +++E VA K+ +A
Sbjct: 848 GKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQE--VAQHNLKEASSASQF 905
Query: 1613 KLTCEKIVKE------RYENMMQQQKLTNISKQQ-----AEQISILQTEVERLRMKTF 1659
+ E ++KE R E M+++++ SK Q ++ + ++++E+L+ + +
Sbjct: 906 E-ELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNY 962
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 77.0 bits (188), Expect = 1e-13
Identities = 184/928 (19%), Positives = 365/928 (39%), Gaps = 140/928 (15%)
Query: 774 DELVLTDVKKE--IPWIQQKSQEAIKKEVNLFSKKRK------EIKQGIKSLSKTILNMM 825
D+L+ T ++ E I + +++++ + L +KKRK E+K+ I L T+ +
Sbjct: 910 DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 969
Query: 826 EENDKLENIAK-LDQQEFGLDLEELERLHDESQEEVAKMIKDVE-MHNLAKSYLAELIKE 883
+E EN K L ++ GLD E +AK+ K+ + + + L +L E
Sbjct: 970 KEKHATENKVKNLTEEMAGLD------------ETIAKLTKEKKALQEAHQQTLDDLQAE 1017
Query: 884 ECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKK-----IEAECLKLR 938
E + K K + +++ +LE L+Q+K +E KL
Sbjct: 1018 EDKVNTLTKA-----------------KIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLE 1060
Query: 939 KEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLE 998
++ AQ I+ ++ DE+ ++ K + S L + + + + + Q
Sbjct: 1061 GDLKLAQESTMDIENDKQQLDEKLKK--KEFEMSGLQSKIEDEQALGMQLQKKIKELQAR 1118
Query: 999 LHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKE-------FEIARVKERNVRIREI 1051
+ EE+I + K ++ + E + ++ E +I K+R +++
Sbjct: 1119 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1178
Query: 1052 ILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQ 1111
DLE EA Q E ++ D + I + K+ + + E + I
Sbjct: 1179 RRDLE--EATLQHEATAATLRKKHA---DSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1233
Query: 1112 DASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKEL 1171
D ++ + + G + E + R + Q + + + EE+++ D + L
Sbjct: 1234 DLASNMETVSKAKGNL-----EKMCRALEDQLSEIKTKE----EEQQRLINDLTAQRARL 1284
Query: 1172 NEERDKYRKSLEAELKKLQNSIQESTQAFD---EHLKRLFERRVKAEMVT---------- 1218
E +Y + L+ E L + + QAF E LKR E +KA+
Sbjct: 1285 QTESGEYSRQLD-EKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHD 1343
Query: 1219 ------NQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDV 1272
EE + + + + S ++ Y T + EA +K + L
Sbjct: 1344 CDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD 1403
Query: 1273 CKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDI------LYKLFKRRPRISKQKTHSETT 1326
+EH + + A+ ++++ ++ +E+ +D+ L K++ K +
Sbjct: 1404 AEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQK 1463
Query: 1327 SVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQK 1386
EL S K ++ +L K + + E LD L K EN+
Sbjct: 1464 CEETHAELEASQKESRSLSTELFKIKNAYE------ESLDQL--------ETLKRENKN- 1508
Query: 1387 VKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEE---KVRFQLNLTIQILLK 1443
++Q+ +DL E KR+ E EK+++++E+ EL EE + + ++I L+
Sbjct: 1509 LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLE 1568
Query: 1444 QGQVELENFQLVLEYSDAI-LINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQIEW 1502
QV+ E + + E + I + +N I + S+ T A + D + ++E
Sbjct: 1569 LNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLD----AEIRSRNDAIRLKKKMEG 1624
Query: 1503 EHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEP--NYEALISIQIGIMEQTIAVLDKM 1560
+ +ME++ N+ A + L R+ Q L + + + + Q + EQ +A++++
Sbjct: 1625 DLNEMEIQLNHANRMA--AEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQ-LAMVERR 1681
Query: 1561 HKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAMGSKLTCEKIV 1620
++L L + + IA +EL+ SER + + + L K
Sbjct: 1682 ANLLQAEIEELRATLEQTERSRKIA--------EQELLDASERVQLLHTQNTSLINTKKK 1733
Query: 1621 KERYENMMQQQKLTNISKQQAEQISILQ 1648
E T+IS+ Q E I+Q
Sbjct: 1734 LE-----------TDISQIQGEMEDIIQ 1750
Score = 45.8 bits (107), Expect = 3e-04
Identities = 47/207 (22%), Positives = 95/207 (45%), Gaps = 20/207 (9%)
Query: 762 HTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKE------IKQGIK 815
+TK+K TD+SQ + + D+ +E ++K+++AI + + +KE +++ K
Sbjct: 1729 NTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788
Query: 816 SLSKTILNMMEENDKLENIA----KLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHN 871
+L +T+ ++ D+ E +A K Q+ + ELE + Q+ + +K + H
Sbjct: 1789 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHE 1848
Query: 872 LAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELE----RVLQQ 927
L +E+ N + ++ K + V+++ +A EE + R +Q
Sbjct: 1849 RKVKELTYQTEEDRKNILRLQDLVDK---LQAKVKSYKRQAEEAEEQSNVNLSKFRRIQH 1905
Query: 928 KKIEAECLKLRKEIVEAQSGVKLIKQR 954
+ EAE R +I E+Q +K R
Sbjct: 1906 ELEEAE---ERADIAESQVNKLRVKSR 1929
Score = 32.7 bits (73), Expect = 3.0
Identities = 43/206 (20%), Positives = 93/206 (45%), Gaps = 26/206 (12%)
Query: 780 DVKKEIPWIQQKSQ------EAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLEN 833
D+K+++ +++++ E ++ + + RK +Q + S+ + + +N L N
Sbjct: 1670 DLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLIN 1729
Query: 834 IAKLDQQEFGLDLEELERLHDES---QEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMA 890
K + + E+E + E+ +E+ K I D M +AE +K+E S
Sbjct: 1730 TKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAM-------MAEELKKEQDTSAH 1782
Query: 891 VKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKIEAECLKLRKEI-------VE 943
++ R K ++ V++ + E+L Q +K+EA +L E+ VE
Sbjct: 1783 LE-RMKK--NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVE 1839
Query: 944 AQSGVKLIKQRHEEDDEEEEEEDKTV 969
A G++ +++ +E + EE+ K +
Sbjct: 1840 AVKGLRKHERKVKELTYQTEEDRKNI 1865
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 76.6 bits (187), Expect = 2e-13
Identities = 177/924 (19%), Positives = 384/924 (41%), Gaps = 148/924 (16%)
Query: 827 ENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIK---DVEMHNLAKSYLAELIKE 883
E +K K + Q+ +L + E E +E++ +++ D+++ A+S +E
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE 904
Query: 884 ECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVE 943
C + K F + ++ +A EE+ E +++K+E EC +L+K+I +
Sbjct: 905 RCDQLIKAK------FQLEAKIKEVTERAEDEEEINA-ELTAKKRKLEDECSELKKDIDD 957
Query: 944 AQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSRE 1003
+ + L K E+ E + ++ T + S L + + + + +L + E
Sbjct: 958 LE--LTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEE 1015
Query: 1004 EKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVR--------IREIILDL 1055
+K+N + K K++ + + ++K+ + ERN R +E ILDL
Sbjct: 1016 DKVNSLNKTKS---KLEQQVEDLESSLEQEKKLRVDL--ERNKRKLEGDLKLAQESILDL 1070
Query: 1056 E-----LEEAVWQPEFEDCE-----KPERTLVVQ---------------DEEITAHKHIK 1090
E L+E + + +FE C+ + E+TL +Q +EEI A + +
Sbjct: 1071 ENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATR 1130
Query: 1091 PWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKE----------DILRMVI 1140
K ++ ++ +E +++ S RL + +E+ K+ D+ +
Sbjct: 1131 A--KTEKQRSDYARE----LEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATL 1184
Query: 1141 PQPAFMA---KPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQEST 1197
A +A K A E +Q + ++ ++L +E+ +++ ++ +L S+ +S
Sbjct: 1185 QHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEID-DLSSSMESVSKSK 1243
Query: 1198 QAFDEHLKRLFER------------RVKAEMVTNQEELKISNLAFSLLLDEELS------ 1239
++ + L ++ R +E+ T + L+ S L+E+ S
Sbjct: 1244 ANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLS 1303
Query: 1240 -SREKF------LNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFK 1292
S++ F L L + K+ + A++ SR D D+ +E Y+ + R+
Sbjct: 1304 RSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALS 1363
Query: 1293 KEFSEI----PGHQVDILYK---LFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAF 1345
K SE+ ++ D + + L + + +++++ SE + K +
Sbjct: 1364 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQ 1423
Query: 1346 AQLMKAMDELDNISNMPEGLDP---------LVWNHFCMTRRAKVENEQKVKQK-AADLL 1395
++ M +++ +++ LD W C +A++E K + + +L
Sbjct: 1424 GEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELF 1483
Query: 1396 EMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTIQILLK-QGQVELE--NF 1452
++ ++ +++ E V++E + + E+ L E+ + TI L K + Q+ELE +
Sbjct: 1484 KLKNAYEEALDQLETVKRENKNLEQEIADLTEQIA--ENGKTIHELEKSRKQIELEKADI 1541
Query: 1453 QLVLEYSDAILINKNI----IEDLNSVIRTQGQKKVASMMESKDVHKRILQIEWEHKKME 1508
QL LE ++A L ++ I+ + ++++ +K+A E + KR Q E +
Sbjct: 1542 QLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSA 1601
Query: 1509 MEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDKMHKKNVENC 1568
++ E ++ + + + + LNE I IQ L +++ E
Sbjct: 1602 LDAEVRSRN----EAIRLKKKMEGDLNE------IEIQ----------LSHANRQAAETL 1641
Query: 1569 KKLLKKLGKFSNQKDIANYAL--SCNLREELVAVSERKDICNAMGSKLTCEKIVKERYEN 1626
K L G+ + + + AL +L+E+L V R ++ A +L ER
Sbjct: 1642 KHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARK 1701
Query: 1627 MMQQQKLTNISKQQAEQISILQTE 1650
+ +Q+ L E++ +L T+
Sbjct: 1702 LAEQELL-----DSNERVQLLHTQ 1720
Score = 43.5 bits (101), Expect = 0.002
Identities = 51/253 (20%), Positives = 107/253 (42%), Gaps = 48/253 (18%)
Query: 762 HTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKE------IKQGIK 815
HTK+K TDL Q + + D ++ ++K+++AI + + +KE +++ K
Sbjct: 1726 HTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1785
Query: 816 SLSKTILNMMEENDKLENIA----KLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHN 871
+L +T+ ++ D+ E +A K Q+ + ELE + Q++ + +K + +
Sbjct: 1786 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYE 1845
Query: 872 LAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKIE 931
+KE + S + L+ L+ ++ + +++
Sbjct: 1846 -------RRVKELTYQSEEDRKNVLR-----------------------LQDLVDKLQVK 1875
Query: 932 AECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTS 991
+ K + E + Q+ L K R + + EE EE + S + L + + DF
Sbjct: 1876 VKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNK--LRAKTRDF----- 1928
Query: 992 LLSSQLELHSREE 1004
SS++ +H EE
Sbjct: 1929 -TSSRMVVHESEE 1940
Score = 42.0 bits (97), Expect = 0.005
Identities = 107/562 (19%), Positives = 213/562 (37%), Gaps = 107/562 (19%)
Query: 758 SDSEHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSL 817
S+ + K TD Q L + KK++ Q S+E ++ VN ++ KQ ++
Sbjct: 1367 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEA-VNAKCASLEKTKQRLQGE 1425
Query: 818 SKTILNMMEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSYL 877
+ ++ +E + L Q+ F L E + +ESQ E+ +K+ ++S
Sbjct: 1426 VEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKE------SRSLS 1479
Query: 878 AELIK-----EECWNSMAVKGRALKCFH--IPCVVENFPMKARTVEELKELERVLQQKKI 930
EL K EE + + R K I + E +T+ EL++ + ++ +K
Sbjct: 1480 TELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKA 1539
Query: 931 ----------------EAECLKLRKEIVEAQSGV-KLIKQRHEEDDEEEEEEDKTVK--- 970
EA+ L+++ E+ + +S + + I ++ EE ++ + +TV+
Sbjct: 1540 DIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQ 1599
Query: 971 ------------------------------YSNLPNYLLGSLSTDFGVDTSLLSSQLEL- 999
S+ +L V L +QL L
Sbjct: 1600 SALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLD 1659
Query: 1000 ---HSREEKINQII-------LLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKER----- 1044
+E+ Q+ LL+ + +++ + + A K E E+ ER
Sbjct: 1660 DALRGQEDLKEQLAIVERRANLLQAEVEELRATLE-QTERARKLAEQELLDSNERVQLLH 1718
Query: 1045 --NVRIREIILDLELEEAVWQPEFEDCEKPERTL------VVQDEEITAHKHIKPWHKAK 1096
N + LE + Q E ED + R + D + A + +K
Sbjct: 1719 TQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEE-LKKEQDTS 1777
Query: 1097 ELIVNHEKEHWLLIQDASTRLRAL--MDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWT 1154
+ +K ++D RL + + GG +++K L I + F + +
Sbjct: 1778 AHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK---LETRIRELEFELEGEQKKN 1834
Query: 1155 EEERKQFKDYEKKVKELNEERDKYRKS----------LEAELKKLQNSIQESTQAFDEHL 1204
E K + YE++VKEL + ++ RK+ L+ ++K + +E+ + + HL
Sbjct: 1835 TESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHL 1894
Query: 1205 KRLFERRVKAEMVTNQEELKIS 1226
+ R+ + E+ +E I+
Sbjct: 1895 TKF--RKAQHELEEAEERADIA 1914
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 75.1 bits (183), Expect = 5e-13
Identities = 169/857 (19%), Positives = 366/857 (42%), Gaps = 157/857 (18%)
Query: 777 VLTDVKKEIPWIQQKS---QEAIKKEVN-LFSKKRKEIKQGIKSLSKTILNMMEENDKL- 831
V ++ EI ++Q++ ++A+ N L SK+ E+ + + ++ + + E+ KL
Sbjct: 411 VREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQ 470
Query: 832 -ENIAKLDQQEFG----LDLEELERLHDESQEEVAKMI-------KDVEMHNLAKSYLAE 879
E + K + ++ + L+E ER +E Q + K +D++ +AK +
Sbjct: 471 QEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQ 530
Query: 880 LIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELK-ELERVLQQKK-IEAECLKL 937
+ + +++ K + + + ++E+ + E L+ +++ +L+Q + ++A+ +
Sbjct: 531 SLHSKLTDTLVSKQQLEQ--RLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQF 588
Query: 938 RKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQL 997
+I S L ++ H+ E+DK +K + + SL S +
Sbjct: 589 HSQIAAQTSASVLAEELHKVI----AEKDKQIKQT----------------EDSLASERD 628
Query: 998 ELHSREEKINQI----ILLKDIIYKVKTVFNNEFDAAYK-QKEFEIARVKERNVRIREII 1052
L S+EE++ I LLK + K++ + N + AA++ +K + VK+ +R+ E
Sbjct: 629 RLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQ 688
Query: 1053 LDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQD 1112
L E+ + EF+ + L + +++ +P K+++ EK IQ+
Sbjct: 689 LQHEISNKM--EEFKILNDQNKALKSEVQKLQTLVSEQP---NKDVVEQMEK----CIQE 739
Query: 1113 ASTRLRALMDMMG-GVLEVK-KEDILRMVIPQPAFMAKP--DAVWTEEERKQFKDYEKKV 1168
+L+ + +++ G+++V KE+ L + + + + K D + ++ F +++
Sbjct: 740 KDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEEL 799
Query: 1169 KELNEERDKYRKS----LEAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELK 1224
K++ E+D KS LEAEL K+ N +++ Q + +K L E ++ Q+ L
Sbjct: 800 KKVIHEKDGKIKSVEELLEAELLKVANK-EKTVQDLKQEIKALKEEIGNVQLEKAQQ-LS 857
Query: 1225 ISNLAFSLLLDEELSSREKFLNNY---LTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLL 1281
I++ L L +E+ +N L K+ + + T + ++ +E+ + K H +
Sbjct: 858 ITSKVQEL--QNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEV- 914
Query: 1282 AEDKVMDRSFKKEFSEIP------------------------GHQVDILY------KLFK 1311
A+ + + S +F E+ + +L KLFK
Sbjct: 915 AQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFK 974
Query: 1312 RRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWN 1371
+ KQ+ + + +S P EL K+ + ++ +ELD++ + E
Sbjct: 975 SQIEQLKQQNYQQASSFPPHEELL---KVISEREKEISGLWNELDSLKDAVEH------- 1024
Query: 1372 HFCMTRRAKVENEQKVKQKAADLLEMATFLQKRV-------------------------- 1405
R+ E +Q+V+ + E+ L +V
Sbjct: 1025 ----QRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGT 1080
Query: 1406 ---EEEEKVQQEIERV--FHELILLQEEKVRFQLNLTIQILLK-QGQVELENFQLVLEYS 1459
EE + ++ +++ H L+ L+ EK + L T IL K Q VE E + ++
Sbjct: 1081 SGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVD 1140
Query: 1460 DAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAW 1519
++ I+ + S + Q+ E+KD+ L+ E EH +ME+E+ ++ + +
Sbjct: 1141 ES----HKTIKQMQSSFTSSEQELERLRSENKDIEN--LRREREHLEMELEKAEMERSTY 1194
Query: 1520 DIQMLFFSRDRQKYLNE 1536
++ R+ + LNE
Sbjct: 1195 VTEV----RELKAQLNE 1207
Score = 51.2 bits (121), Expect = 8e-06
Identities = 155/773 (20%), Positives = 319/773 (41%), Gaps = 106/773 (13%)
Query: 722 SEILDYYQKLLISLSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQDELVLTDV 781
+E+ + KL +L S E + + + E + + L Q+E + +
Sbjct: 527 NEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKE-ESLQMQVQDILEQNEALKAQI 585
Query: 782 KKEIPWIQ-QKSQEAIKKEVN-LFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQ 839
++ I Q S + +E++ + ++K K+IKQ SL+ + + ++L++I ++
Sbjct: 586 QQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNF 645
Query: 840 QEFGLDLEELERLHDE---SQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAV----- 891
++++L+ L +E + E+ KM + V + + L E ++ E N M
Sbjct: 646 L-LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILN 704
Query: 892 -KGRALKCF--HIPCVVENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGV 948
+ +ALK + +V P K + ++++E+ +Q+K E LK +E++E +G+
Sbjct: 705 DQNKALKSEVQKLQTLVSEQPNK----DVVEQMEKCIQEKD---EKLKTVEELLE--TGL 755
Query: 949 KLIKQRHEE---------------DDEEEEEEDKTVKYSNLPNYLLGSLSTDFG----VD 989
+ + EE D + ++ D+ V +++L L + G V+
Sbjct: 756 IQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQ-VSFASLVEELKKVIHEKDGKIKSVE 814
Query: 990 TSLLSSQLELHSREEKIN----QIILLKDIIYKVKTVFNNEFDAAYKQKEFE-IARVKER 1044
L + L++ ++E+ + +I LK+ I V+ + K +E + + + KE
Sbjct: 815 ELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEE 874
Query: 1045 NVRIREIILD-LELEEAVWQPEFEDCEKPERTLVVQDEEITAH--KHIKPWHKAKEL-IV 1100
+ + +L+ E + A +D ++ +L +E+ H K + +EL IV
Sbjct: 875 QMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIV 934
Query: 1101 NHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQ 1160
EKE+ L RL A++ L K + +L+ V ++E K
Sbjct: 935 LKEKENEL------KRLEAMLKERESDLSSKTQ-LLQDV---------------QDENKL 972
Query: 1161 FKDYEKKVKELN----------EERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFER 1210
FK +++K+ N EE K E E+ L N + A + K+ ER
Sbjct: 973 FKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNER 1032
Query: 1211 RVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTS--EAVRKSRE 1268
+ + E V + + + L + + LS E +L+ + + + + TS E V+
Sbjct: 1033 QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGE-WLHGFEKKAKECMAGTSGSEEVKVLEH 1091
Query: 1269 DLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTHSETTSV 1328
L E + L E + +K +E G IL KL + + + S
Sbjct: 1092 KLKEADEMHTLLQLECE----KYKSVLAETEG----ILQKLQRSVEQEENKWKVKVDESH 1143
Query: 1329 VPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQ--- 1385
++ S ++ +L +++N+ E L+ + +A++E
Sbjct: 1144 KTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMEL-------EKAEMERSTYVT 1196
Query: 1386 KVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTI 1438
+V++ A L E T L+ E +KV ++ + L L+Q + V+ + T+
Sbjct: 1197 EVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTV 1249
Score = 48.9 bits (115), Expect = 4e-05
Identities = 110/525 (20%), Positives = 213/525 (40%), Gaps = 65/525 (12%)
Query: 1169 KELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNL 1228
K+L E DK ++ E + K S++ + DE L + + K+ ++ Q+ LK S+
Sbjct: 269 KKLKTETDK--ENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVI--QDALKKSSK 324
Query: 1229 AFSLLLDEELSSREKFL----NNYLTRKQHEKSQTSEAV-RKSREDLDVC--KEHYDNLL 1281
L +L ++K L + K K T E + K R ++ + K+ L
Sbjct: 325 GELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLE 384
Query: 1282 AEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTH-SETTSVVPFGELPGSGKL 1340
E V + E Q+ K + R ++ + H + ++ + +L
Sbjct: 385 KEHNVFQNKIHVSYQETQQMQM----KFQQVREQMEAEIAHLKQENGILRDAVSNTTNQL 440
Query: 1341 NKDAFAQLMKAMDELDNISN-MPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLL--EM 1397
A+L K + + N + E L + + KV+ + A+ E+
Sbjct: 441 ESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEV 500
Query: 1398 ATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTIQILLKQGQVELENFQL--- 1454
++++KR E E QQ+++ F + +E +V+ + L+ + Q+E QL
Sbjct: 501 QSYIRKRTAEHEAAQQDLQSKF----VAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES 556
Query: 1455 -----------------VLEYSDAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRI 1497
+LE ++A+ K I+ +S I Q V + K + ++
Sbjct: 557 EQKRVNKEESLQMQVQDILEQNEAL---KAQIQQFHSQIAAQTSASVLAEELHKVIAEKD 613
Query: 1498 LQIEWEHKKMEMEREDLNQK---AWDIQMLFF--SRDRQKYLNEPNYEALISIQIGIMEQ 1552
QI+ + ER+ L K DIQ + F + QK N +A + ++ M+Q
Sbjct: 614 KQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQ 673
Query: 1553 TIAVL-DKMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSER--KDICNA 1609
++ V DK+ + ++ K+ +F D N AL +++ VSE+ KD+
Sbjct: 674 SVYVKDDKIRLLEEQLQHEISNKMEEFKILND-QNKALKSEVQKLQTLVSEQPNKDVVEQ 732
Query: 1610 MGSKLTCEKIVKERYENMMQQQKLTNISKQQA----EQISILQTE 1650
M EK ++E+ E + ++L Q E+++ ++TE
Sbjct: 733 M------EKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTE 771
Score = 48.1 bits (113), Expect = 7e-05
Identities = 150/803 (18%), Positives = 335/803 (41%), Gaps = 125/803 (15%)
Query: 906 ENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEE 965
E P+ T +E ++ KK + E + + + ++ A + + L+ ++ E
Sbjct: 192 EALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREV 251
Query: 966 DKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNN 1025
+K P+ + G S +L + +K N + KD + +KT+ +
Sbjct: 252 IDLLK----PDQVEGIQK----------SGTKKLKTETDKENAEVKFKDFLLSLKTMMFS 297
Query: 1026 EFDA-----AYKQKE--FEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVV 1078
E +A K+K + A K + +I L+ ++ + ED +
Sbjct: 298 EDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQ 357
Query: 1079 QDEEITAHKHIK--PWHKAKELIVNHEKEH----------WLLIQDASTRLRALMDMM-G 1125
+E+ K + K+ I EKEH + Q + + + + M
Sbjct: 358 LTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEA 417
Query: 1126 GVLEVKKED-ILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDK------Y 1178
+ +K+E+ ILR + + ++ + E K +DY + V EL E+ K
Sbjct: 418 EIAHLKQENGILRDAVSNTT--NQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQ 475
Query: 1179 RKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEEL 1238
+K+ E +L+ +QE+ + ++E + + R+ AE Q++L+ +A +E
Sbjct: 476 KKNAEQAATQLKVQLQEAERRWEE--VQSYIRKRTAEHEAAQQDLQSKFVAKE---NEVQ 530
Query: 1239 SSREKFLNNYLTRKQHEK--SQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFS 1296
S K + ++++Q E+ Q E+ +K + + ++L +++ + ++ S
Sbjct: 531 SLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHS 590
Query: 1297 EIPGHQ-----VDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKA 1351
+I + L+K+ + + KQ S + +D +L
Sbjct: 591 QIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLAS--------------ERD---RLTSK 633
Query: 1352 MDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQKV-KQKAADLLEMATFLQKRVEEEEK 1410
+EL +I NM +F + +A+V+ Q + ++AA E+ Q +++K
Sbjct: 634 EEELKDIQNM----------NFLL--KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK 681
Query: 1411 VQQEIERVFHELILLQEEKVRFQLNLTIQILLKQGQV---ELENFQLVLEYSDAILINKN 1467
++ E++ HE+ EE +IL Q + E++ Q ++ NK+
Sbjct: 682 IRLLEEQLQHEISNKMEE---------FKILNDQNKALKSEVQKLQTLVSEQP----NKD 728
Query: 1468 IIEDLNSVIRTQGQ--KKVASMMESKDV-----HKRILQIEWEHKKMEMEREDLNQKAWD 1520
++E + I+ + + K V ++E+ + + + I E+ + E +DL K D
Sbjct: 729 VVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND 788
Query: 1521 IQMLFFS--RDRQKYLNEPNYEALISIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKF 1578
Q+ F S + +K ++E + + + S++ + + + V +K +K V++ K+ +K L
Sbjct: 789 -QVSFASLVEELKKVIHEKDGK-IKSVEELLEAELLKVANK--EKTVQDLKQEIKAL--- 841
Query: 1579 SNQKDIANYALSCNLREELVAVSERKDICNAMGSK----LTCEKIVKERYENMMQQQKLT 1634
+++I N L ++L S+ +++ N + K T + +++E+ +++ K
Sbjct: 842 --KEEIGNVQL--EKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWL 897
Query: 1635 NISKQQAEQISILQTEVERLRMK 1657
+++ E + EV + +K
Sbjct: 898 QDLQEENESLKAHVQEVAQHNLK 920
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 75.1 bits (183), Expect = 5e-13
Identities = 204/1036 (19%), Positives = 420/1036 (40%), Gaps = 160/1036 (15%)
Query: 734 SLSSAMDKENHYLSTTPKVSVDLGSDSEH-------TKQKASTDLSQDELVLTDVKKEIP 786
SL SA + HY + D G+DS H K+ T L Q+ L KE
Sbjct: 49 SLGSADELFKHYEAVH-----DAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEK 103
Query: 787 WIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDL 846
W ++ ++ ++K L ++ K G+ + S L +E+ +LE + Q ++
Sbjct: 104 WYSEELKKELEKYQGLQQQEAKP--DGLVTDSSAELQSLEQ--QLE-----EAQTENFNI 154
Query: 847 EELERLHDESQEEVAKMIKDVE--------MHNLAKSYLAELIKEECWNSMAVKGRALKC 898
++++ L ++ ++A I D++ + A+ + L +E + ++ +
Sbjct: 155 KQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL 214
Query: 899 FHIP-----CVVENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQ 953
P V++ ++ +T+ + LER + +K++ EC KL+ + +++ + ++
Sbjct: 215 LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRS 274
Query: 954 RHEEDDEE-EEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILL 1012
+ +E + K + N L T + +LL + + EEK N+
Sbjct: 275 ELAKGPQEVAVYVQELQKLKSSVNELTQKNQT---LTENLLKKEQDYTKLEEKHNE---- 327
Query: 1013 KDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKP 1072
++V A QK+ + +++ R E ++ + E EK
Sbjct: 328 -------ESVSKKNIQATLHQKDLDCQQLQSRL---------SASETSLHRIHVELSEKG 371
Query: 1073 ERTLVVQDE--EI-TAHKHIKPWHKAKELIVNHEKEHWLLIQ------------------ 1111
E T +++E E+ T ++H+K K + +++H L +Q
Sbjct: 372 EATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLG 431
Query: 1112 DASTRLRALMDMMGGVLEVKKEDI--LRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVK 1169
+A RL+ + L K++ + L++ + + K + E + Q K K
Sbjct: 432 EAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL----DKTK 487
Query: 1170 ELNEERDKYRKSLEAELKKLQNSIQESTQAF---DEHLKRLFERRVKAEMVTNQEELKIS 1226
+ ++E+ ++S A+L++ QN +++ + D+ ++ L K++ + E +
Sbjct: 488 QQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547
Query: 1227 NLAFSLLLDE-------ELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDL-DVCKEHYD 1278
+L + E +L + L +T+ + SE+ ++++E+L D +E
Sbjct: 548 DLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKA 607
Query: 1279 NL-LAEDKVMDRSFKKEFSEIPGH---------QVDILYK-----LFKRRPRISKQK--- 1320
+L A+D+V+ S + +E+ Q+DI K L + Q+
Sbjct: 608 HLRAAQDRVL--SLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADL 665
Query: 1321 -THSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRA 1379
H +T + K+ K D+ ++ S + L + + ++
Sbjct: 666 QNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725
Query: 1380 KVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQ---EIERVFHELI--LLQEEKVRFQL 1434
+ E E ++K+ AD LE+ ++ +++ ++ +Q ++E EL L E+++
Sbjct: 726 E-ELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSST 784
Query: 1435 NLTIQ------ILLKQGQVELENFQLVLEYSDAILINKNII--EDLNSVIRTQ------- 1479
L +Q +KQ + E + +L+ L + I E+LN+ I+T
Sbjct: 785 RLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKV 844
Query: 1480 GQKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNY 1539
+K A M E V ++ ++ K + E E NQK + D +K E +
Sbjct: 845 KMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAIL-----DLEKTCKELKH 899
Query: 1540 EALISIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREE--- 1596
+ + ++ + EQ L K +K E +L +L Q A L N +EE
Sbjct: 900 QLQVQMENTLKEQ--KELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL 957
Query: 1597 -------LVAVSERKDICNAMGSKLTCEKIVKERYENMMQQQKLTNISKQQA---EQISI 1646
+ ++K A+ +L + K EN +QQQ LT +++ A E+IS+
Sbjct: 958 QGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQ-LTQAAQELAAEKEKISV 1016
Query: 1647 LQTEVERLRMKTFPAL 1662
LQ E+ +TF L
Sbjct: 1017 LQNNYEK-SQETFKQL 1031
Score = 50.1 bits (118), Expect = 2e-05
Identities = 159/883 (18%), Positives = 357/883 (40%), Gaps = 133/883 (15%)
Query: 765 QKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLS--KTIL 822
++A DL Q + D ++I ++ Q++ K+ ++L K+R+++ I++ +L
Sbjct: 505 REAQNDLEQVLRQIGDKDQKIQNLEALLQKS-KENISLLEKEREDLYAKIQAGEGETAVL 563
Query: 823 NMMEENDKL--ENIAKLDQQ---EFGLDLEELERLHDESQEEVAKM-------------I 864
N ++E + E + +L ++ + + E LHD+ QE+ A + +
Sbjct: 564 NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV 623
Query: 865 KDVEMH-NLAKSYLAEL-IKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELK-EL 921
++ N +K +++L I+ + + + A K + + +++ + EL
Sbjct: 624 NELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL 683
Query: 922 ERVLQQ-KKIEAECLKLRKEIVEAQSGVKLIKQRH---EEDDEEEEEEDKTVKYSNLPNY 977
++ Q ++ A+ ++ + +S +K K+++ E+ EE E + K ++ +L
Sbjct: 684 NKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVK 743
Query: 978 LLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFE 1037
+ L++ LEL + E L K + + + V + D K + E
Sbjct: 744 ASKEQALQDLQQQRQLNTDLELRATE-------LSKQLEMEKEIVSSTRLDLQKKSEALE 796
Query: 1038 IARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKE 1097
I++ + E E+ + + +FE + + +Q EE+ K
Sbjct: 797 ---------SIKQKLTKQEEEKQILKQDFETLSQETK---IQHEELNNRIQTTVTELQK- 843
Query: 1098 LIVNHEKEHWLLIQDAST---RLRALMDMM-GGVLEVKKEDI--------LRMVIPQPAF 1145
V EKE L+ + ST +L + D + E +KE+ L +
Sbjct: 844 --VKMEKE--ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH 899
Query: 1146 MAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLK 1205
+ T +E+K+ K +K KE + + S++ +L + QN+++++ + +
Sbjct: 900 QLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQG 959
Query: 1206 RLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRK 1265
+ E + +E Q E L ++L EL + + Q + +Q ++ +
Sbjct: 960 NINELKQSSEQKKKQIEALQGELKIAVLQKTELEN----------KLQQQLTQAAQELAA 1009
Query: 1266 SREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTHSET 1325
+E + V + +Y+ +FK+ S+ G + ++L T +
Sbjct: 1010 EKEKISVLQNNYEK-------SQETFKQLQSDFYGRESELL-------------ATRQDL 1049
Query: 1326 TSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQ 1385
SV +L A ++L + N + L+ + AK EQ
Sbjct: 1050 KSVE----------------EKLSLAQEDLISNRNQIGNQNKLIQE----LKTAKATLEQ 1089
Query: 1386 KVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTIQILLKQG 1445
+K L E LQ +E+ ++E+ +L ++E K R + +T ++ +
Sbjct: 1090 DSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEIT-KLNEELK 1148
Query: 1446 QVELENFQLVLEYSDA--ILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQIEWE 1503
+LE+ + + DA +LI + + + Q K S+ + + KR QI +
Sbjct: 1149 SHKLESIKEITNLKDAKQLLIQQKL----------ELQGKADSLKAAVEQEKRNQQILKD 1198
Query: 1504 HKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNY---EALISIQIGIMEQTIAVLDKM 1560
+++ E E+L ++ + + S ++K + + EA +++QI + + + + K
Sbjct: 1199 --QVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKE 1256
Query: 1561 HKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSER 1603
+ + +L K+ + + + N ++E A+ ER
Sbjct: 1257 WQSSQRRVSELEKQTDDLRGEIAVLEATVQ-NNQDERRALLER 1298
Score = 35.4 bits (80), Expect = 0.47
Identities = 83/383 (21%), Positives = 158/383 (41%), Gaps = 57/383 (14%)
Query: 735 LSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQE 794
L +++KE + ++ ++L S E Q +T L Q+E ++ I ++Q S++
Sbjct: 915 LKKSLEKEKE---ASHQLKLELNSMQEQLIQAQNT-LKQNEKEEQQLQGNINELKQSSEQ 970
Query: 795 AIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEE---LER 851
KK+ E QG L +L E +KL+ QE + E+ L+
Sbjct: 971 ---------KKKQIEALQG--ELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQN 1019
Query: 852 LHDESQEEVAKMIKDV---EMHNLAKSYLAELIKEECWNSMA----VKGRALKCFHIPCV 904
+++SQE ++ D E LA + ++E+ S+A + R +
Sbjct: 1020 NYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKL--SLAQEDLISNRNQIGNQNKLI 1077
Query: 905 VENFPMKARTVEELKELERVLQQK-----KIEAECLKLRKEIVEAQS---GVKLIKQRHE 956
E KA ++ + E+ LQ++ I+ E KE+V +S ++ IK R E
Sbjct: 1078 QELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQE 1137
Query: 957 EDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSR---------EEKIN 1007
++ + EE K+ K ++ ++ L+ +LEL + +EK N
Sbjct: 1138 KEITKLNEELKSHKLESIK-----EITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRN 1192
Query: 1008 QIILLKDIIYKVKTVFNNEF-------DAAYKQKEFEIARVKERNVRIREIILDLELEEA 1060
Q I LKD + K + EF + K+KE + + +E ++ I L
Sbjct: 1193 QQI-LKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLG 1251
Query: 1061 VWQPEFEDCEKPERTLVVQDEEI 1083
+ E++ ++ L Q +++
Sbjct: 1252 TVKKEWQSSQRRVSELEKQTDDL 1274
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 73.6 bits (179), Expect = 2e-12
Identities = 205/1098 (18%), Positives = 433/1098 (39%), Gaps = 215/1098 (19%)
Query: 735 LSSAMDKENHYLSTTPKVSVDLGSDSEHTK-QKASTDLSQDELV-LTDVKKEIPWIQQKS 792
L S + H T+ D SE K Q +L Q+ + D + E+ +Q
Sbjct: 184 LESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAH 243
Query: 793 QEAI-------KKEVNLFSKKRKEIK----QGIKSLSKTILNMMEENDKLENIAKLDQQE 841
Q+ + ++E++ + ++ +E++ QG + +T L+ + E K + ++++ E
Sbjct: 244 QQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVE 303
Query: 842 FGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSYL---AELIKEECWNSMAVKGRALKC 898
+E+LE + ++++ D ++ + L I EEC N L+C
Sbjct: 304 STKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECEN------LKLEC 357
Query: 899 FHIPCVVENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEED 958
+ P + + + E ER+L Q E +L++ + +A++ + + ++++
Sbjct: 358 SKLQ------PSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDN 411
Query: 959 ------------------------DEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLS 994
E+EE + +K +N + + + D +D+ L
Sbjct: 412 SLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHD 471
Query: 995 SQLELHSREEKINQ-------------------------IILLKD-----------IIYK 1018
+L L ++E+++NQ +IL+KD II K
Sbjct: 472 LRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISK 531
Query: 1019 VKTVFNNEFDAAYKQKEFEIARVKERNVRIREIIL------DLELEEAVWQPEFEDC--- 1069
+K N+E ++ ++ ++ KE +V+ ++I DL L + + + E+
Sbjct: 532 LKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQ 591
Query: 1070 --EKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLR--ALMDMMG 1125
+ E + +Q E + +HI+ + I N + L QD+++ + L +
Sbjct: 592 LNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQS--LNQDSNSNFKDTLLKEREA 649
Query: 1126 GVLEVKKE----DILRMVIPQPAFMAKPD----AVWTEEERKQFKD---------YEKKV 1168
V +K+ + L + + AF K + + E+ R Q ++ EK
Sbjct: 650 EVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNT 709
Query: 1169 --------------------KELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLF 1208
K L EE +KY K++E EL +N + Q EHL +L
Sbjct: 710 IVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIE-ELSNARNLNTSALQLEHEHLIKLN 768
Query: 1209 ERRVK--AEMVTNQEELKI----------SNLAFSLLLDEELSSREKFLNNYLTRK---Q 1253
+++ AE+ N E++ S+L L + ++ +E F+ R Q
Sbjct: 769 QKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQ 828
Query: 1254 HEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQ----------- 1302
E + S+A+RK+ E L E D L K + ++E + Q
Sbjct: 829 EELDKYSQALRKN-EILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKT 887
Query: 1303 VDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMP 1362
+D + +L +++ K H E E+ K+ +D Q M L ++
Sbjct: 888 LDSVTELASEVSQLNTIKEHLEE-------EIKHHQKIIED---QNQSKMQLLQSLQEQK 937
Query: 1363 EGLDPLVWNHFCMT---RRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVF 1419
+ +D + H M + +E ++++K + ++ T L EE + +Q + +F
Sbjct: 938 KEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLH---EERQDIQTDNSDIF 994
Query: 1420 HEL----ILLQEEKVRFQLN------LTIQILLKQGQVELENFQLVLEYSDAILINKNII 1469
E + ++ + L+ L I ++ +++L N + + ++K+ +
Sbjct: 995 QETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEV 1054
Query: 1470 EDLNSVIRTQG------QKKVASMMESKDVHKRILQIEWEHKKMEMERED----LNQKAW 1519
L +I+ + +++S ++DV + ++ + + MERE LN+K
Sbjct: 1055 GKLTQIIQQKDLEIQALHARISSTSHTQDV----VYLQQQLQAYAMEREKVFAVLNEKTR 1110
Query: 1520 DIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFS 1579
+ L + + ALI +Q ++ + + + ++ ++ L +
Sbjct: 1111 ENSHLKTEYHKMMDIVAAKEAALIKLQ----DENKKLSTRFESSGQDMFRETIQNLSRII 1166
Query: 1580 NQKDIANYALSCNLREELVAVSERKDICNAMG--SKLTCEKIVKERYENMMQQQKLTNIS 1637
+KDI ALS + L+AV + N G + E++++ER + Q +K+
Sbjct: 1167 REKDIEIDALSQKC-QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWK 1225
Query: 1638 KQQAEQISILQTEVERLR 1655
+Q + +Q E +L+
Sbjct: 1226 QQVMTTVQNMQHESAQLQ 1243
Score = 63.9 bits (154), Expect = 1e-09
Identities = 182/954 (19%), Positives = 390/954 (40%), Gaps = 145/954 (15%)
Query: 765 QKASTDLSQDELVLT----DVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKT 820
QK D +Q ++ L + KKE+ + + ++ LF +K +EIK K++ +
Sbjct: 916 QKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQI 975
Query: 821 ILNMMEENDKLENIAKLDQQEF---GLDLEELERLHDESQEEVAKMIKDVEMHNLAKSYL 877
+ EE ++ QE L++E HD S+ E +++K ++ L L
Sbjct: 976 KTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLL 1035
Query: 878 AELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKIEAECLKL 937
E K + ++ + +E+ +L +++QQK +E + L
Sbjct: 1036 NE-----------------KNISLTKQIDQL-----SKDEVGKLTQIIQQKDLEIQALHA 1073
Query: 938 RKEIVEAQSGVKLIKQRHEEDDEEEEE-----EDKTVKYSNLPNYLLGSLSTDFGVDTSL 992
R V ++Q+ + E E+ +KT + S+L + + +L
Sbjct: 1074 RISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAAL 1133
Query: 993 LSSQLE---LHSREEK------------INQIILLKDI-----IYKVKTVF--------- 1023
+ Q E L +R E +++II KDI K +T+
Sbjct: 1134 IKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTG 1193
Query: 1024 -------NNEFDAAYKQKEF---EIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPE 1073
+N+F+ ++++ ++ +++E ++ + +++ E A Q E +
Sbjct: 1194 NEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQA-- 1251
Query: 1074 RTLVVQDE----EITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLE 1129
+ LV D ++ I+ + + + + N +E +Q + +L D++ G L+
Sbjct: 1252 QVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQE-LAQVQHSIGQLCNTKDLLLGKLD 1310
Query: 1130 VKKEDI--LRMVIPQPA--FMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAE 1185
+ + ++ PQ A A V +E ++ E+ K L +E+D ++L+
Sbjct: 1311 IISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSL-QEKDATIRTLQEN 1369
Query: 1186 LKKLQNSIQESTQAF-DEHLKRLFE-RRVKAEMVTNQEELKISNLAFSLLLDEELSSREK 1243
+L +SI +++ EH + E +++K + Q+ LK +L D+ LSS E
Sbjct: 1370 NHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNEN 1429
Query: 1244 FLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQV 1303
F N K +E +AV +E + + + L E++ + +++ + +E Q
Sbjct: 1430 FTN-----KVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQE 1484
Query: 1304 DILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPE 1363
+ F R + + HS + F +L + K EL+ + N +
Sbjct: 1485 TNMK--FSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTG---------ELNQLLNAVK 1533
Query: 1364 GLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELI 1423
+ + ++ + + +KQK + + +Q+ ++E + QE+ER+ + L+
Sbjct: 1534 SMQEKT----VVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLL 1589
Query: 1424 LLQEEKVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQKK 1483
++ R L + + +L VLE + ++ + N +E+ + Q +
Sbjct: 1590 ESEDSYTREAL------AAEDREAKLRKKVTVLE--EKLVSSSNAMENASH----QASVQ 1637
Query: 1484 VASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALI 1543
V S+ E +V + Q + ++ + +E + Q A + L + + +A+
Sbjct: 1638 VESLQEQLNVVSK--QRDETALQLSVSQEQVKQYALSLANLQMVLEH----FQQEEKAMY 1691
Query: 1544 SIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSER 1603
S ++ +Q IA KKN EN L K+ D AN AL R ++E+
Sbjct: 1692 SAELEKQKQLIA----EWKKNAEN---LEGKVISLQECLDEANAALDSASR-----LTEQ 1739
Query: 1604 KDICNAMGSKLTCEKIVKERYENMMQQQKLTNISKQQAEQISILQTEVERLRMK 1657
D+ E+I + + +N ++Q+ L ++ K+ + + +V+++ M+
Sbjct: 1740 LDVKE--------EQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMR 1785
Score = 62.4 bits (150), Expect = 4e-09
Identities = 112/546 (20%), Positives = 214/546 (39%), Gaps = 98/546 (17%)
Query: 788 IQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKL-ENIAKLDQQEFGLDL 846
++ E + + L ++ +E+++ ++ TI + E N +L ++IA
Sbjct: 1330 LRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATS-------- 1381
Query: 847 EELERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVE 906
ELER E + K +K+ + L +L+KE+ + +K ++ + E
Sbjct: 1382 -ELERKEHEQTDSEIKQLKEKQ------DVLQKLLKEK---DLLIKAKSDQLLSSN---E 1428
Query: 907 NFPMKARTVEELKELERVLQQKKI--EAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEE 964
NF K E L++ L+++ + E + KL+ E K+++ ++ E +
Sbjct: 1429 NFTNKVNENELLRQAVTNLKERILILEMDIGKLKGE------NEKIVETYRGKETEYQAL 1482
Query: 965 EDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEK------------------I 1006
++ +K+S + L + E HS +EK +
Sbjct: 1483 QETNMKFSMM-----------------LREKEFECHSMKEKALAFEQLLKEKEQGKTGEL 1525
Query: 1007 NQIILLKDIIYKVKTVFNNEFDA---AYKQKEFEIARVKERNVRIR--EIILDLELEEAV 1061
NQ++ + + VF E D A KQK+ E ++ R+R E + ELE
Sbjct: 1526 NQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLR 1585
Query: 1062 WQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALM 1121
+ L +D E K + +E +V+ AS ++ +L
Sbjct: 1586 NHLLESEDSYTREALAAEDREAKLRKKVTV---LEEKLVSSSNAMENASHQASVQVESLQ 1642
Query: 1122 DMMGGVLEVKKEDILRMVIPQPAF------MAKPDAV---WTEEERKQFKDYEKKVKELN 1172
+ + V + + E L++ + Q +A V + +EE+ + +K K+L
Sbjct: 1643 EQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLI 1702
Query: 1173 EERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSL 1232
E K ++LE ++ LQ + E+ A D + + VK E + EELK N
Sbjct: 1703 AEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQI---EELKRQNELRQE 1759
Query: 1233 LLDEE-------LSSREKFLNNYLTRK------QHEKSQTSEAVRKSREDLDVCKEHYDN 1279
+LD+ +S E ++ L R K+Q E +R L V +E +
Sbjct: 1760 MLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQ 1819
Query: 1280 LLAEDK 1285
L +D+
Sbjct: 1820 LFHDDQ 1825
Score = 60.5 bits (145), Expect = 1e-08
Identities = 214/1116 (19%), Positives = 428/1116 (38%), Gaps = 235/1116 (21%)
Query: 730 KLLISLSSAMDKE-NHYLSTTPKVSVDLGSDSEHTKQ--------KASTDLSQDELVLTD 780
K +I + + K+ N S K+ DL + + Q D+ +++L+ ++
Sbjct: 509 KHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSE 568
Query: 781 VK-KEIPWIQQKSQEAIKKEVNLFSKK--------------RKEIKQGIKSLSKTILNMM 825
V ++ +QK ++ ++ V+ +K ++ I+Q + LS+ +M
Sbjct: 569 VALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELM 628
Query: 826 EE---------NDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSY 876
+ D L + + + +L ELE+L+ E + K+ DV+M N
Sbjct: 629 QSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLN----ENLKKVAFDVKMENEKLVL 684
Query: 877 LAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKIEAECLK 936
E ++ + +A G +VE M+ +E E +K++ E K
Sbjct: 685 ACEDVRHQLEECLA--GNNQLSLEKNTIVETLKMEKGEIEA----ELCWAKKRLLEEANK 738
Query: 937 LRKEIVEAQSGVKLIKQRHEEDDEE--EEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLS 994
K I E + L + + E + + K ++ + L + + TD +LS
Sbjct: 739 YEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNI-EQMDTDHKETKDVLS 797
Query: 995 SQLELHSREEKINQIILLKDI-IYKVK---TVFNNEFDA-------------AYKQKEFE 1037
S LE ++++ Q+I K+I I K+K + E D ++K+
Sbjct: 798 SSLE---EQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRS 854
Query: 1038 IARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKE 1097
+ +KE N ++E + L E++ P + +TL D + + KE
Sbjct: 855 LGSMKEENNHLQEELERLREEQSRTAPVADP-----KTL---DSVTELASEVSQLNTIKE 906
Query: 1098 LIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKE-DILRMVIPQ------PAFMAKPD 1150
+ K H +I+D + ++ M ++ + E KKE D R Q F+ K +
Sbjct: 907 HLEEEIKHHQKIIEDQN---QSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDE 963
Query: 1151 AVWT------------EEERKQFKD------YEKKVKELNEERDKYRKSL-EAELKKLQN 1191
+ + EER+ + E KV+ LN E + L +AE ++L
Sbjct: 964 EIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVK 1023
Query: 1192 SIQESTQAFDEHLKRLFERRV---------------KAEMVTNQEELKISNLAFSL---- 1232
I+E + +K L E+ + K + Q++L+I L +
Sbjct: 1024 GIKER----ELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTS 1079
Query: 1233 ------LLDEELSS----REKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLA 1282
L ++L + REK L K E S K + + + L
Sbjct: 1080 HTQDVVYLQQQLQAYAMEREKVFA-VLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQD 1138
Query: 1283 EDKVMDRSFKKEFSEIPGHQVDILYKLFKRRP-RISKQKTHSETTSVVPFGELPGS--GK 1339
E+K + F+ ++ + L ++ + + I +T V G+ G
Sbjct: 1139 ENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGG 1198
Query: 1340 LNKDAFAQLMKAMDEL-DNISNMPEGLDPLVWNHFCMTRRAKVENE-----QKVKQKAAD 1393
+N + F +L++ D+L + M E W MT +++E +++ Q A
Sbjct: 1199 VNSNQFEELLQERDKLKQQVKKMEE------WKQQVMTTVQNMQHESAQLQEELHQLQAQ 1252
Query: 1394 LL-----------EMATFLQKRVEEEEKVQ---QEIERVFHELILLQEEKVRFQLNLTIQ 1439
+L + +Q + E K++ QE+ +V H + QL T
Sbjct: 1253 VLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSI---------GQLCNTKD 1303
Query: 1440 ILLKQGQV---ELENFQLVLEYS-DAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHK 1495
+LL + + +L + L+ S + + +K+ + +S + Q +++ ++ KD
Sbjct: 1304 LLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATI 1363
Query: 1496 RILQIE----------------WEHKKMEMEREDLNQKAWDIQMLFFSRD---------- 1529
R LQ EH++ + E + L +K +Q L +D
Sbjct: 1364 RTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQL 1423
Query: 1530 ---RQKYLNEPNYEALISIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQKDIAN 1586
+ + N+ N L+ + +++ I +L+ ++ K +K+ + K+
Sbjct: 1424 LSSNENFTNKVNENELLRQAVTNLKERILILEM----DIGKLKGENEKIVETYRGKETEY 1479
Query: 1587 YALSCNLREELVAVSERKDICNAMGSK-LTCEKIVKERYEN-----------MMQQQKLT 1634
AL + + + E++ C++M K L E+++KE+ + + Q+ T
Sbjct: 1480 QALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKT 1539
Query: 1635 NISKQQAEQISI-----------LQTEVERLRMKTF 1659
+ +Q+ +Q+ + LQ EV+RLR K F
Sbjct: 1540 VVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEF 1575
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 71.6 bits (174), Expect = 6e-12
Identities = 174/806 (21%), Positives = 343/806 (42%), Gaps = 90/806 (11%)
Query: 761 EHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKT 820
E +Q + ++ +L L V E + + ++ I ++ N K K++ + +++
Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLED--RIAEF 1004
Query: 821 ILNMMEENDKLENIAKLDQQEFGL--DLEELERLHDESQEEVAKMIKDVEMHNLAKS-YL 877
N+ EE +K +++AKL + + DLEE R ++ ++E+ K + +E + S +
Sbjct: 1005 TTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQI 1064
Query: 878 AELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKE-LERVLQQKKIEAECLK 936
AEL + + E A+ EEL+ L RV ++ + LK
Sbjct: 1065 AELQAQ--------------------IAELKMQLAKKEEELQAALARVEEEAAQKNMALK 1104
Query: 937 LRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQ 996
+E+ E+Q I + E+ + E +K K L +L T+ ++Q
Sbjct: 1105 KIREL-ESQ-----ISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQ 1158
Query: 997 LELHS-REEKINQIILLKDIIYKVKT--VFNNEFDAAYKQKEFEIARVKERNVRIREIIL 1053
EL S RE+++N IL K + + KT E + Q E+A E+ R++
Sbjct: 1159 QELRSKREQEVN--ILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKA--- 1213
Query: 1054 DLELEEAVWQPEFEDCEKP-ERTLVVQDEEITAHKHIKPWHKAKELIV--NHEKEHWLLI 1110
LE+A E E E E +++Q + + HK K + +EL V N + +
Sbjct: 1214 --NLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTEL 1271
Query: 1111 QDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWT--EEERKQFKDYEKKV 1168
D T+L+ +D + G+L ++ A ++ +EE +Q K+
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL 1331
Query: 1169 KELNEERDKYRKSLEAELKKLQNSIQE--STQAFDEHLKRLFERRV----KAEMVTNQEE 1222
K++ +E++ +R+ LE E + N ++ + A +K+ E V AE V + +
Sbjct: 1332 KQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ 1391
Query: 1223 LKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQ---TSEAVRKSREDLDVCKEHYDN 1279
+ L S +E++++ +K L TR Q E + R+S +L+ ++ +D
Sbjct: 1392 KDLEGL--SQRHEEKVAAYDK-LEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQ 1448
Query: 1280 LLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGK 1339
LLAE+K + + +E + K +S + E ++ EL K
Sbjct: 1449 LLAEEKTISAKYAEERDRAEAEARE------KETKALSLARALEE--AMEQKAELERLNK 1500
Query: 1340 LNKDAFAQLMKAMDE----LDNISNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLL 1395
+ LM + D+ + + L+ V T+ ++E+E + + A L
Sbjct: 1501 QFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQV--EEMKTQLEELEDELQATEDAKLRL 1558
Query: 1396 EM------ATF---LQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTIQILLKQGQ 1446
E+ A F LQ R E+ E+ ++++ R E+ E++ R Q ++ + K+ +
Sbjct: 1559 EVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDE-RKQRSMAV-AARKKLE 1616
Query: 1447 VELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQIEWEHKK 1506
++L++ + ++ + NKN E + + + Q Q K M E D +I + K+
Sbjct: 1617 MDLKDLEAHIDSA-----NKNRDEAIKQLRKLQAQMK-DCMRELDDTRASREEILAQAKE 1670
Query: 1507 MEMEREDLNQKAWDIQMLFFSRDRQK 1532
E + + + + +Q + +R K
Sbjct: 1671 NEKKLKSMEAEMIQLQEELAAAERAK 1696
Score = 62.0 bits (149), Expect = 5e-09
Identities = 183/937 (19%), Positives = 386/937 (41%), Gaps = 139/937 (14%)
Query: 761 EHTKQKA---STDLSQD----ELVLTDVKKEIPWIQQKSQEAIKK------EVNLFSKKR 807
E T++K STDLS + + ++K ++ +++ Q A+ + + N+ KK
Sbjct: 1047 EKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKI 1106
Query: 808 KEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEEL--------------ERLH 853
+E++ I L + + E N A+ +++ G +LE L + L
Sbjct: 1107 RELESQISELQEDL----ESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELR 1162
Query: 854 DESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKAR 913
+ ++EV + K +E AK++ A++ + +S AV+ A + V N +
Sbjct: 1163 SKREQEVNILKKTLEEE--AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQ 1220
Query: 914 TVE----ELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTV 969
T+E EL +VL Q K ++E + + E + VK + + ++ V
Sbjct: 1221 TLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQV 1280
Query: 970 KYSNLPNYLL--GSLSTDFGVDTSLLSSQLELHSR--EEKINQIILLKDIIYKVKTVFNN 1025
+ N+ L S S+ D S L SQL+ +E+ Q + L + +V+ N
Sbjct: 1281 ELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDE-KN 1339
Query: 1026 EFDAAYKQKEFEIARVKERNVRIREIILDLE--LEEAVWQPEFEDCEKPERTLVVQDEEI 1083
F +++E ++++ + + D++ +E++V E E+ +R L +D E
Sbjct: 1340 SFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGC--LETAEEVKRKLQ-KDLEG 1396
Query: 1084 TAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQP 1143
+ +H +E + ++K ++ TRL+ +D + L+ +++ + Q
Sbjct: 1397 LSQRH-------EEKVAAYDK-----LEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQK 1444
Query: 1144 AFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEH 1203
F D + EE+ K E++ + E R+K K+L + L+ ++++ + E
Sbjct: 1445 KF----DQLLAEEKTISAKYAEERDRAEAEAREKETKALSLA-RALEEAMEQKAEL--ER 1497
Query: 1204 LKRLFERRVKAEMVTNQE------ELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKS 1257
L + F ++ M + + EL+ S A ++E + L + E
Sbjct: 1498 LNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEE--------MKTQLEELEDELQ 1549
Query: 1258 QTSEAVRKSREDLDVCKEHYD-NLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRI 1316
T +A + +L K ++ +L D+ + K+ ++ + ++ + +R +
Sbjct: 1550 ATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAV 1609
Query: 1317 SKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMT 1376
+ +K + + + K +A QL K ++ + LD + +
Sbjct: 1610 AARKKLEMDLKDLE-AHIDSANKNRDEAIKQLRKLQAQMKDCMRE---LDDTRASREEIL 1665
Query: 1377 RRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHEL-------ILLQEEK 1429
+AK ENE+K+K A+++++ L + + QQE + + E+ L EEK
Sbjct: 1666 AQAK-ENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEK 1724
Query: 1430 VRFQ---LNLTIQILLKQGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQKKVAS 1486
R + L ++ +QG EL N +L A L I DLN + R+ QK +
Sbjct: 1725 RRLEARIAQLEEELEEEQGNTELINDRL----KKANLQIDQINTDLN-LERSHAQKNENA 1779
Query: 1487 MMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQ 1546
Q+E ++K+++++ +++ + Y+A I+
Sbjct: 1780 RQ----------QLERQNKELKVKLQEMEGTV-----------------KSKYKASITAL 1812
Query: 1547 IGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDI 1606
+ Q LD K+ CK++ + K KD+ + +E + KD
Sbjct: 1813 EAKIAQLEEQLDNETKERQAACKQVRRTEKKL---KDVL-----LQVDDERRNAEQYKDQ 1864
Query: 1607 CNAMGSKLTCEKIVKERYENMMQQQKLTNISKQQAEQ 1643
+ ++L K +K + E ++ + N S+++ ++
Sbjct: 1865 ADKASTRL---KQLKRQLEEAEEEAQRANASRRKLQR 1898
Score = 33.1 bits (74), Expect = 2.3
Identities = 59/264 (22%), Positives = 117/264 (44%), Gaps = 31/264 (11%)
Query: 1401 LQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTIQILLKQGQVELENFQLVLEYSD 1460
LQ +EEE + +E EL+ ++E+++ + LT L Q Q+ E QL +
Sbjct: 838 LQVSRQEEEMMAKE-----EELVKVREKQLAAENRLTEMETL-QSQLMAEKLQLQEQLQA 891
Query: 1461 AILINKNIIEDLNSVIRTQGQK--KVASMMESK--DVHKRILQIEWEHKKMEMEREDLNQ 1516
+ E+L + + + Q+ ++ +E++ + +R ++ E KKM+ ++L +
Sbjct: 892 ETELCAEA-EELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEE 950
Query: 1517 KAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLG 1576
+ + + +K E + L QI + +Q NCK L K
Sbjct: 951 QLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQ--------------NCK--LAKEK 994
Query: 1577 KFSNQKDIANYALSCNLREELV-AVSERKDICNAMGSKLT--CEKIVKERYENMMQQQKL 1633
K + IA + + EE ++++ K+ AM + L + K+R E ++KL
Sbjct: 995 KLLEDR-IAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKL 1053
Query: 1634 TNISKQQAEQISILQTEVERLRMK 1657
S ++QI+ LQ ++ L+M+
Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQ 1077
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 71.6 bits (174), Expect = 6e-12
Identities = 123/594 (20%), Positives = 246/594 (41%), Gaps = 61/594 (10%)
Query: 735 LSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQE 794
L ++E + +V S+ + K TD Q L + KK++ Q ++E
Sbjct: 1345 LREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEE 1404
Query: 795 AIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEELERLHD 854
A+ + VN ++ K +++ + ++ +E ++ Q+ F L E ++ ++
Sbjct: 1405 AV-EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE 1463
Query: 855 ESQEEVAKMIKDVEMHNLAKSYLAELIK-----EECWNSMAVKGRALKCF--HIPCVVEN 907
ESQ E+ K+ A+S EL K EE + R K I + E
Sbjct: 1464 ESQSELESSQKE------ARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1517
Query: 908 FPMKARTVEELKELERVLQQKKIEAECLKLRKE---------IVEAQSGVKLIKQRHEED 958
+ V EL+++ + L+ +K+E + E I+ AQ IK E
Sbjct: 1518 LGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERK 1577
Query: 959 DEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSR-EEKINQIILLKDIIY 1017
E++EE + K ++ ++ SL T +T + L + + E +N++ +
Sbjct: 1578 LAEKDEEMEQAKRNH--QRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHAN 1635
Query: 1018 KVKTVFNNE---FDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFED----CE 1070
++ + + K + ++ N ++E I +E + Q E E+ E
Sbjct: 1636 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1695
Query: 1071 KPERTLVVQDEE-ITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLE 1129
+ ER+ + ++E I + ++ H ++N +K+ ++ T+L++ ++ V E
Sbjct: 1696 QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKK----MESDLTQLQS--EVEEAVQE 1749
Query: 1130 VKK-EDILRMVIPQPAFMA---KPDAVWTEEERKQFKDYEKKVKELNEERD--------- 1176
+ E+ + I A MA K + + + K+ E+ +K+L D
Sbjct: 1750 CRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKG 1809
Query: 1177 --KYRKSLEAELKKLQNSIQESTQAFDEHLK--RLFERRVKAEMVTNQEELKISNLAFSL 1232
K + LEA +++L+ ++ + E +K R ERR+K E+ EE K + L
Sbjct: 1810 GKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIK-ELTYQTEEDKKNLLRLQD 1868
Query: 1233 LLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKV 1286
L+D +L + K + + + RK + +LD +E D +AE +V
Sbjct: 1869 LVD-KLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERAD--IAESQV 1919
Score = 59.3 bits (142), Expect = 3e-08
Identities = 170/932 (18%), Positives = 367/932 (39%), Gaps = 160/932 (17%)
Query: 839 QQEFGLDLEELERLHDESQEEVAKMIK------DVEMHNLAKSYLAELIKEECWNSMAVK 892
++EFG E LE+ +E KM+ D+++ A+ +E C +K
Sbjct: 855 KEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERC--DQLIK 912
Query: 893 GRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIK 952
+ + V+ + EE+ E +++K+E EC +L+K+I + + + L K
Sbjct: 913 NK----IQLEAKVKEMNERLEDEEEMNA-ELTAKKRKLEDECSELKKDIDDLE--LTLAK 965
Query: 953 QRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILL 1012
E+ E + ++ T + + L + + + + +L E+K+N L
Sbjct: 966 VEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNS--LS 1023
Query: 1013 KDIIYKVKTVFNNEFDAAYKQK-EFEIARVK---ERNVRI-REIILDLE-----LEEAVW 1062
K + + V + E ++K ++ R K E ++++ +E I+DLE LEE +
Sbjct: 1024 KSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLK 1083
Query: 1063 QPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWL----------LIQD 1112
+ EF+ ++ + ++DE++ A + K + + I E+E L D
Sbjct: 1084 KKEFDINQQNSK---IEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSD 1140
Query: 1113 ASTRLRALMDMM---GGVLEVK--------------KEDILRMVIPQPAFMA---KPDAV 1152
S L + + + GG V+ + D+ + A A K A
Sbjct: 1141 LSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD 1200
Query: 1153 WTEEERKQFKDYEKKVKELNEERDKYRKSLE-------------AELKKLQNSIQESTQA 1199
E +Q + ++ ++L +E+ +++ L+ A L+K+ ++++ QA
Sbjct: 1201 SVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLED--QA 1258
Query: 1200 FDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEE-------------LSSREKFLN 1246
+ +K +R + T + +L+ N + L+E+ + + + L
Sbjct: 1259 NEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLK 1318
Query: 1247 NYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEI----PGHQ 1302
L + K+ + A++ +R D D+ +E Y+ + R K SE+ ++
Sbjct: 1319 RQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYE 1378
Query: 1303 VDILYK---LFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNIS 1359
D + + L + + +++++ +E + K ++ M +++ +
Sbjct: 1379 TDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN 1438
Query: 1360 NMPEGLDP---------LVWNHFCMTRRAKVENEQK-VKQKAADLLEMATFLQKRVEEEE 1409
LD W ++++E+ QK + + +L ++ ++ +E E
Sbjct: 1439 AAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLE 1498
Query: 1410 KVQQEIERVFHELILLQE------------EKVRFQLNLTIQILLKQGQVELENFQLVLE 1457
++E + + E+ L E EKVR QL ++ + Q LE + LE
Sbjct: 1499 TFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQL----EVEKLELQSALEEAEASLE 1554
Query: 1458 YSDAILINKNI-IEDLNSVIRTQGQKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQ 1516
+ + ++ + + + I + +K M ++K H+R+ ++ ++ E N
Sbjct: 1555 HEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRV--VDSLQTSLDAETRSRN- 1611
Query: 1517 KAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLG 1576
++L + + LNE ME ++ ++M + + K L L
Sbjct: 1612 -----EVLRVKKKMEGDLNE-------------MEIQLSHANRMAAEAQKQVKSLQSLLK 1653
Query: 1577 KFSNQKDIANYALSCNLREELVAVSERKDICNAMGSKLTCEKIVKERYENMMQQQ----- 1631
Q D A A + +L+E + V R ++ A +L ER + +Q+
Sbjct: 1654 DTQIQLDDAVRA-NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETS 1712
Query: 1632 -----------KLTNISKQQAEQISILQTEVE 1652
L N K+ ++ LQ+EVE
Sbjct: 1713 ERVQLLHSQNTSLINQKKKMESDLTQLQSEVE 1744
Score = 57.8 bits (138), Expect = 9e-08
Identities = 121/587 (20%), Positives = 239/587 (40%), Gaps = 104/587 (17%)
Query: 1154 TEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKL---QNSIQESTQAFDEHL------ 1204
TE+E K+ ++KE E+ + RK LE ++ L +N +Q QA ++L
Sbjct: 847 TEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEER 906
Query: 1205 -------KRLFERRVKA--EMVTNQEELKISNLAFSLLLDEELSSREKFLNNY---LTRK 1252
K E +VK E + ++EE+ A L++E S +K +++ L +
Sbjct: 907 CDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKV 966
Query: 1253 QHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKR 1312
+ EK T V+ E++ E L E K + + ++ ++ + D + L K
Sbjct: 967 EKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEE-DKVNSLSKS 1025
Query: 1313 RPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNH 1372
+ ++ +Q +L GS + K L +A +L EG L
Sbjct: 1026 KVKLEQQ-----------VDDLEGSLEQEKKVRMDLERAKRKL-------EGDLKLTQES 1067
Query: 1373 FCMTRRAKVENEQKVKQKAADLLE----------MATFLQKRVEEE-------------- 1408
K++ E+K+K+K D+ + +A LQK+++E
Sbjct: 1068 IMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAE 1127
Query: 1409 -------EKVQQEIERVFHELILLQEE-----KVRFQLNLTIQILLKQGQVELENFQLVL 1456
EK++ ++ R E+ EE V+ ++N + ++ + +LE L
Sbjct: 1128 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH 1187
Query: 1457 EYSDAILINKNI---------IEDLNSVIRTQGQKKVASMMESKDVHKRILQIEWEHKKM 1507
E + A L K+ I++L V + ++K +E DV + QI +
Sbjct: 1188 EATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL 1247
Query: 1508 EMEREDLNQKAWDIQMLFFSRDRQKYLNE-PNYEALISIQIG----IMEQTIAVLDKM-- 1560
E L +A + ++ + Q+ LN+ A + + G +E+ A++ ++
Sbjct: 1248 EKVSRTLEDQANEYRVKL--EEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTR 1305
Query: 1561 ----HKKNVENCKKLLKKLGKFSN--QKDIANYALSCN-LREELVAVSERKDICNAMGSK 1613
+ + +E+ K+ L++ GK N + + C+ LRE+ +E K + SK
Sbjct: 1306 GKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSK 1365
Query: 1614 LTCEKIV-KERYEN--MMQQQKLTNISKQQAEQISILQTEVERLRMK 1657
E + +YE + + ++L K+ A+++ + VE + K
Sbjct: 1366 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAK 1412
Score = 56.6 bits (135), Expect = 2e-07
Identities = 134/756 (17%), Positives = 306/756 (40%), Gaps = 124/756 (16%)
Query: 790 QKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEEL 849
Q+ ++ ++KE + F + ++ ++ + K N+ + + LE+ A E+ + LEE
Sbjct: 1213 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQAN----EYRVKLEEA 1268
Query: 850 ERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFP 909
+R ++ + AK+ E LA+ +L ++E S +G
Sbjct: 1269 QRSLNDFTTQRAKL--QTENGELAR----QLEEKEALISQLTRG---------------- 1306
Query: 910 MKARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTV 969
K +++++L+R L+++ L + A+ L+++++EE+ E + E + +
Sbjct: 1307 -KLSYTQQMEDLKRQLEEEGKAKNALA--HALQSARHDCDLLREQYEEETEAKAELQRVL 1363
Query: 970 KYSNLPNYLLGSLSTDFGVDTSLLSSQLE---------LHSREEKINQIILLKDIIYKVK 1020
+N + T + D + +LE L EE + + + K K
Sbjct: 1364 SKANSE---VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTK 1420
Query: 1021 TVFNNEFD---AAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLV 1077
NE + ++ A + ++ +I+ + + + Q E E +K R+L
Sbjct: 1421 HRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLS 1480
Query: 1078 VQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRAL---------MDMMGGVL 1128
+ K + ++ E + ++E+ L ++ S L ++ + L
Sbjct: 1481 TE-----LFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQL 1535
Query: 1129 EVKKEDILRMVIPQPAFMAKPDA--VWTEEERKQFK-DYEKKVKELNEERDKYRKSLEAE 1185
EV+K ++ + A + + + + E Q K + E+K+ E +EE ++ +++ +
Sbjct: 1536 EVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRV 1595
Query: 1186 LKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSREKFL 1245
+ LQ S+ T++ +E L RVK +M + E++I L+ + + E + K L
Sbjct: 1596 VDSLQTSLDAETRSRNEVL------RVKKKMEGDLNEMEI-QLSHANRMAAEAQKQVKSL 1648
Query: 1246 NNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAE-DKVMDRSFKKEFSEIPGHQVD 1304
+ L Q + A +E++ + + + L AE +++ + E S Q
Sbjct: 1649 QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQ-- 1706
Query: 1305 ILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEG 1364
+L + R+ Q HS+ TS++ K + QL ++E
Sbjct: 1707 ---ELIETSERV--QLLHSQNTSLI------NQKKKMESDLTQLQSEVEE---------- 1745
Query: 1365 LDPLVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELIL 1424
V+ + ++KA + A + + +++E+ +ER+ +
Sbjct: 1746 ---------------AVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1790
Query: 1425 LQEEKVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQKKV 1484
++ ++ +L+ QI LK G+ +L+ + + +L + + ++
Sbjct: 1791 TIKD-LQHRLDEAEQIALKGGKKQLQKLEA-------------RVRELEGELEAEQKRNA 1836
Query: 1485 ASMMESKDVHKRILQIEW---EHKKMEMEREDLNQK 1517
S+ + +RI ++ + E KK + +DL K
Sbjct: 1837 ESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDK 1872
Score = 56.2 bits (134), Expect = 3e-07
Identities = 162/867 (18%), Positives = 337/867 (38%), Gaps = 159/867 (18%)
Query: 761 EHTKQKASTDLSQDELVLTDVKKEIPWIQQK------SQEAIKKEVNLFSKKRKEIKQGI 814
+ Q+A DL +E + + K ++Q+ S E KK + +++++ +
Sbjct: 1002 QEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDL 1061
Query: 815 KSLSKTILNMMEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAK 874
K ++I+++ ENDKL+ KL ++EF ++ ++ ++ DE + +A ++ N A+
Sbjct: 1062 KLTQESIMDL--ENDKLQLEEKLKKKEFDIN-QQNSKIEDE--QVLALQLQKKLKENQAR 1116
Query: 875 SYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQ------- 927
E ++EE + + K +++ EL+E+ L++
Sbjct: 1117 ---IEELEEELEAERTARAKVEK------------LRSDLSRELEEISERLEEAGGATSV 1161
Query: 928 -----KKIEAECLKLRKEIVEA----QSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYL 978
KK EAE K+R+++ EA ++ ++++H + E
Sbjct: 1162 QIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE----------------- 1204
Query: 979 LGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEI 1038
LG E+I+ + +K + K K+ F E D E
Sbjct: 1205 LG-----------------------EQIDNLQRVKQKLEKEKSEFKLELDDVTSNME--- 1238
Query: 1039 ARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKEL 1098
++ + + ++ LE + ++ + E+ ++ Q ++ EL
Sbjct: 1239 -QIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTEN--------GEL 1289
Query: 1099 IVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEER 1158
E++ L+ Q +L M ++++E + + A+ D + R
Sbjct: 1290 ARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDC---DLLR 1346
Query: 1159 KQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVT 1218
+Q+++ + EL K + K + + T+ +E K+L +R AE
Sbjct: 1347 EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAV 1406
Query: 1219 NQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYD 1278
K S+L E+ R L N + + +++ A LD + ++D
Sbjct: 1407 EAVNAKCSSL-------EKTKHR---LQNEIEDLMVDVERSNAAAAA----LDKKQRNFD 1452
Query: 1279 NLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTHSET---------TSVV 1329
+LAE K + E + +LFK + + H ET +
Sbjct: 1453 KILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS 1512
Query: 1330 PFGELPGSGKLNKDAFAQLMKAM--DELDNISNMPEGLDPLVWNHFCMTR------RAKV 1381
E G G N ++ K + ++L+ S + E L + R + K
Sbjct: 1513 DLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1572
Query: 1382 ENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLN-LTIQI 1440
E E+K+ +K + +E A +RV + + + E +L ++K+ LN + IQ+
Sbjct: 1573 EIERKLAEKDEE-MEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQL 1631
Query: 1441 -----LLKQGQVELENFQLVL-----EYSDAILINKNIIEDLNSVIRTQGQKKVASMMES 1490
+ + Q ++++ Q +L + DA+ N ++ E++ V R
Sbjct: 1632 SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVER------------- 1678
Query: 1491 KDVHKRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIM 1550
+LQ E E + +E+ + ++K + Q L + +R + L+ N +LI+ Q M
Sbjct: 1679 ---RNNLLQAELEELRAVVEQTERSRKLAE-QELIETSERVQLLHSQN-TSLIN-QKKKM 1732
Query: 1551 EQTIAVLDKMHKKNVENCKKLLKKLGK 1577
E + L ++ V+ C+ +K K
Sbjct: 1733 ESDLTQLQSEVEEAVQECRNAEEKAKK 1759
Score = 34.7 bits (78), Expect = 0.79
Identities = 49/234 (20%), Positives = 99/234 (42%), Gaps = 42/234 (17%)
Query: 764 KQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKE------IKQGIKSL 817
K+K +DL+Q + + + +E ++K+++AI + + +KE +++ K++
Sbjct: 1729 KKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNM 1788
Query: 818 SKTILNMMEENDKLENIA----KLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLA 873
+TI ++ D+ E IA K Q+ + ELE + Q+ A+ +K +
Sbjct: 1789 EQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVK-----GMR 1843
Query: 874 KSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKIEAE 933
KS IKE + + K + L L+ ++ + +++ +
Sbjct: 1844 KS--ERRIKELTYQTEEDK-----------------------KNLLRLQDLVDKLQLKVK 1878
Query: 934 CLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFG 987
K + E E Q+ L K R + + +E EE + S + L + S D G
Sbjct: 1879 AYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNK--LRAKSRDIG 1930
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 70.1 bits (170), Expect = 2e-11
Identities = 193/904 (21%), Positives = 359/904 (39%), Gaps = 121/904 (13%)
Query: 790 QKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEEL 849
+K + + K+V + + + KQ +++ ++M+E +LE + ++ ++ L
Sbjct: 497 EKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKIL 556
Query: 850 ER-----------LHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKC 898
E+ L SQ +KD+E N L E IKE S + +
Sbjct: 557 EQENEHLNQTVSSLRQRSQISAEARVKDIEKEN---KILHESIKE---TSSKLSKIEFEK 610
Query: 899 FHIPCVVENFPMKARTVEELK------ELERVLQQKKIEAECLKLRKEIVEAQSGVKLIK 952
I +E++ K EEL+ E E L QKKI LK+ E +EA ++
Sbjct: 611 RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN--LKITCEKIEA------LE 662
Query: 953 QRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILL 1012
Q + E + E + KT+ + L SL + ++ L LEL E + +
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLESLEKE---NSQLDEENLELRRNVESLKCASMK 719
Query: 1013 KDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKP 1072
+ +E + K E A K+ R+ L++E Q E+ K
Sbjct: 720 MAQLQLENKELESEKEQLKKGLELLKASFKKTE-RLEVSYQGLDIENQRLQKTLENSNKK 778
Query: 1073 ERTLV--VQDEEI---TAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGV 1127
+ L +QD E+ T K+++ + + + EKE+ L Q+ S + +
Sbjct: 779 IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE--- 835
Query: 1128 LEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELK 1187
K+ LR A+ EE + + EK+ K L++E Y++S LK
Sbjct: 836 ---KENKRLRQ-------QAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESC-VRLK 884
Query: 1188 KLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNN 1247
+L+ +E + +K L R ++V+ E+LK + L E+L+ + +
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLR--EDLVS--EKLKTQQMNNDL---EKLTHELEKIGL 937
Query: 1248 YLTRKQHEKSQTSEAVRKSREDLD-VCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDIL 1306
R H++ T + + L+ K+ + + E+K+ + E S Q+
Sbjct: 938 NKERLLHDEQSTDDRYKLLESKLESTLKKSLE--IKEEKIAALEARLEESTNYNQQLRQE 995
Query: 1307 YKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNK------DAFAQLMKAMDELDNISN 1360
K K+ KQ+ E + P SG+ NK + +L+K D L +
Sbjct: 996 LKTVKKNYEALKQRQDEER---MVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVER 1052
Query: 1361 MPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFH 1420
L T+ ++E + Q A +L + E+ +Q + ++
Sbjct: 1053 NNATLQ--AEKQALKTQLKQLETQNNNLQ--AQILALQRQTVSLQEQNTTLQTQNAKLQV 1108
Query: 1421 ELILLQEEKVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQG 1480
E L + +N Q+L++Q +E EN ++ E D + ++I+D +
Sbjct: 1109 ENSTLNSQSTSL-MNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELL-- 1165
Query: 1481 QKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYE 1540
++ AS ES + + ++ HK +E+E DL E Y
Sbjct: 1166 HERQASEYES--LISKHGTLKSAHKNLEVEHRDL---------------------EDRYN 1202
Query: 1541 ALISIQIGIMEQTIAVL----DKMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREE 1596
L+ Q G +E +L +KM +N +N + + + K + D N+ S L+E
Sbjct: 1203 QLLK-QKGQLEDLEKMLKVEQEKMLLEN-KNHETVAAEYKKLCGENDRLNHTYSQLLKET 1260
Query: 1597 LVAVSERKDICNAM-GSKLTCEKI------VKERYENM-MQQQKLTNISKQQAEQISILQ 1648
V ++ K++ + + SKL ++ +KE+Y+ + + KL N Q E +S L+
Sbjct: 1261 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNN----QCELLSQLK 1316
Query: 1649 TEVE 1652
+E
Sbjct: 1317 GNLE 1320
Score = 49.3 bits (116), Expect = 3e-05
Identities = 105/540 (19%), Positives = 210/540 (38%), Gaps = 99/540 (18%)
Query: 1155 EEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKA 1214
E+E Q K K+ ++ ERD RK +E +++ Q+ DE L +E
Sbjct: 381 EKENLQLK---AKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWE----L 433
Query: 1215 EMVTNQEEL-KISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVC 1273
E ++ EL + + ++E SSR L + + E ++ V + R +D
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSR-------LLKLEMENQSLTKTVEELRTTVD-- 484
Query: 1274 KEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTHSETTSVVPFGE 1333
+ G+ IL K+ K R+SK+ E V
Sbjct: 485 -----------------------SVEGNASKIL-KMEKENQRLSKKVEILENEIVQEKQS 520
Query: 1334 LPGSGKLNKDAF---AQLMKAMDEL-----DNISNMPEGLDPLVWNHFCMTRRAKVENEQ 1385
L L+KD AQL K ++ L I + + + L + +R+++ E
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
Query: 1386 KVK-------------QKAADLLEMATFLQKRVEEE-----------EKVQQEIERVFHE 1421
+VK ++ + L F ++++++E E+++ E+ + E
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640
Query: 1422 LILLQEEKVRFQLNLTIQILLKQGQVELE----NFQLVLEYSDAILINKNIIEDLNSVIR 1477
LLQ++ ++ L+Q ELE + L+ + +E NS +
Sbjct: 641 NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLD 700
Query: 1478 TQGQKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEP 1537
+ + ++ K ++ Q++ E+K++E E+E L + ++ F +R
Sbjct: 701 EENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER------- 753
Query: 1538 NYEALISIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREEL 1597
+ + Q + + ++ +K +EN K +++L ++ N L NL EEL
Sbjct: 754 ---------LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL-EEL 803
Query: 1598 VAVSERKDICNAMGSKLTCEKIVKERYENMMQQQKLTNISKQQAEQISILQTEVERLRMK 1657
S+R + L E E+ + ++++ +K+ +Q I T +E +K
Sbjct: 804 KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKE-----NKRLRQQAEIKDTTLEENNVK 858
Score = 41.2 bits (95), Expect = 0.008
Identities = 111/580 (19%), Positives = 229/580 (39%), Gaps = 99/580 (17%)
Query: 761 EHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKT 820
+ T + ++ + Q E L D++ E +Q+ +E + + SK+ +++++ KSL +
Sbjct: 769 QKTLENSNKKIQQLESELQDLEMENQTLQKNLEE-----LKISSKRLEQLEKENKSLEQE 823
Query: 821 ILNMMEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSYLAEL 880
+ ++ +LE K L + + D + EE I ++E N S +
Sbjct: 824 TSQLEKDKKQLEKENK--------RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGI 875
Query: 881 IKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKIEAECL-KLRK 939
KE C R E KE + ++++ I+ + L LR+
Sbjct: 876 YKESC--------------------------VRLKELEKENKELVKRATIDIKTLVTLRE 909
Query: 940 EIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLE- 998
++V KL Q+ D E+ E + + N L STD LL S+LE
Sbjct: 910 DLVSE----KLKTQQMNNDLEKLTHELEKIGL-NKERLLHDEQSTDDRY--KLLESKLES 962
Query: 999 -----LHSREEKINQIILLKDIIYKVKTVFNNEFDAAYK--QKEFEIARVKERNVRIREI 1051
L +EEKI + + + T +N + K +K +E + ++ R+ +
Sbjct: 963 TLKKSLEIKEEKIAAL----EARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS 1018
Query: 1052 ILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKE------ 1105
+ E+ W+ E + E L V+D I ++ K+ + K+
Sbjct: 1019 SPPISGEDNKWERESQ--ETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN 1076
Query: 1106 -----------HWLLIQDASTRLR---ALMDMMGGVLEVKKEDIL----RMVIPQPAFMA 1147
+ +Q+ +T L+ A + + L + ++ +++I Q +
Sbjct: 1077 NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLEN 1136
Query: 1148 KPDAVWTEEERKQ------FKDYEKKVKELNEERDKYRKSL---EAELKKLQNSIQESTQ 1198
+ ++V E E + KD+E K++ L+E + +SL LK +++ +
Sbjct: 1137 ENESVIKEREDLKSLYDSLIKDHE-KLELLHERQASEYESLISKHGTLKSAHKNLEVEHR 1195
Query: 1199 AFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQ 1258
++ +L +++ + E + +++ + E +++ K L R H SQ
Sbjct: 1196 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1255
Query: 1259 TSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEI 1298
+ K E L ++ +LL K+ + EFS++
Sbjct: 1256 ----LLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKL 1291
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 69.7 bits (169), Expect = 2e-11
Identities = 193/903 (21%), Positives = 356/903 (39%), Gaps = 118/903 (13%)
Query: 790 QKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEEL 849
+K + + K+V + + + KQ +++ ++M+E +LE + ++ ++ L
Sbjct: 497 EKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKIL 556
Query: 850 ER-----------LHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKC 898
E+ L SQ +KD+E N L E IKE S + +
Sbjct: 557 EQENEHLNQTVSSLRQRSQISAEARVKDIEKEN---KILHESIKE---TSSKLSKIEFEK 610
Query: 899 FHIPCVVENFPMKARTVEELK------ELERVLQQKKIEAECLKLRKEIVEAQSGVKLIK 952
I +E++ K EEL+ E E L QKKI LK+ E +EA ++
Sbjct: 611 RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN--LKITCEKIEA------LE 662
Query: 953 QRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILL 1012
Q + E + E + KT+ + L SL + ++ L LEL E + +
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLESLEKE---NSQLDEENLELRRNVESLKCASMK 719
Query: 1013 KDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKP 1072
+ +E + K E A K+ R+ L++E Q E+ K
Sbjct: 720 MAQLQLENKELESEKEQLKKGLELLKASFKKTE-RLEVSYQGLDIENQRLQKTLENSNKK 778
Query: 1073 ERTLV--VQDEEI---TAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGV 1127
+ L +QD E+ T K+++ + + + EKE+ L Q+ S + +
Sbjct: 779 IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE--- 835
Query: 1128 LEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELK 1187
K+ LR A+ EE + + EK+ K L++E Y++S LK
Sbjct: 836 ---KENKRLRQ-------QAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESC-VRLK 884
Query: 1188 KLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNN 1247
+L+ +E + +K L R ++V+ E+LK + L E+L+ + +
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLR--EDLVS--EKLKTQQMNNDL---EKLTHELEKIGL 937
Query: 1248 YLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILY 1307
R H++ T ++ K E + E+K+ + E S Q+
Sbjct: 938 NKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL 997
Query: 1308 KLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNK------DAFAQLMKAMDELDNISNM 1361
K K+ KQ+ E + P SG+ NK + +L+K D L +
Sbjct: 998 KTVKKNYEALKQRQDEER---MVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERN 1054
Query: 1362 PEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHE 1421
L T+ ++E + Q A +L + E+ +Q + ++ E
Sbjct: 1055 NATLQ--AEKQALKTQLKQLETQNNNLQ--AQILALQRQTVSLQEQNTTLQTQNAKLQVE 1110
Query: 1422 LILLQEEKVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQ 1481
L + +N Q+L++Q +E EN ++ E D + ++I+D +
Sbjct: 1111 NSTLNSQSTSL-MNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELL--H 1167
Query: 1482 KKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEA 1541
++ AS ES + + ++ HK +E+E DL E Y
Sbjct: 1168 ERQASEYES--LISKHGTLKSAHKNLEVEHRDL---------------------EDRYNQ 1204
Query: 1542 LISIQIGIMEQTIAVL----DKMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREEL 1597
L+ Q G +E +L +KM +N +N + + + K + D N+ S L+E
Sbjct: 1205 LLK-QKGQLEDLEKMLKVEQEKMLLEN-KNHETVAAEYKKLCGENDRLNHTYSQLLKETE 1262
Query: 1598 VAVSERKDICNAM-GSKLTCEKI------VKERYENM-MQQQKLTNISKQQAEQISILQT 1649
V ++ K++ + + SKL ++ +KE+Y+ + + KL N Q E +S L+
Sbjct: 1263 VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNN----QCELLSQLKG 1318
Query: 1650 EVE 1652
+E
Sbjct: 1319 NLE 1321
Score = 49.3 bits (116), Expect = 3e-05
Identities = 105/540 (19%), Positives = 210/540 (38%), Gaps = 99/540 (18%)
Query: 1155 EEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKA 1214
E+E Q K K+ ++ ERD RK +E +++ Q+ DE L +E
Sbjct: 381 EKENLQLK---AKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWE----L 433
Query: 1215 EMVTNQEEL-KISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVC 1273
E ++ EL + + ++E SSR L + + E ++ V + R +D
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSR-------LLKLEMENQSLTKTVEELRTTVD-- 484
Query: 1274 KEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTHSETTSVVPFGE 1333
+ G+ IL K+ K R+SK+ E V
Sbjct: 485 -----------------------SVEGNASKIL-KMEKENQRLSKKVEILENEIVQEKQS 520
Query: 1334 LPGSGKLNKDAF---AQLMKAMDEL-----DNISNMPEGLDPLVWNHFCMTRRAKVENEQ 1385
L L+KD AQL K ++ L I + + + L + +R+++ E
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
Query: 1386 KVK-------------QKAADLLEMATFLQKRVEEE-----------EKVQQEIERVFHE 1421
+VK ++ + L F ++++++E E+++ E+ + E
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640
Query: 1422 LILLQEEKVRFQLNLTIQILLKQGQVELE----NFQLVLEYSDAILINKNIIEDLNSVIR 1477
LLQ++ ++ L+Q ELE + L+ + +E NS +
Sbjct: 641 NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLD 700
Query: 1478 TQGQKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEP 1537
+ + ++ K ++ Q++ E+K++E E+E L + ++ F +R
Sbjct: 701 EENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER------- 753
Query: 1538 NYEALISIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREEL 1597
+ + Q + + ++ +K +EN K +++L ++ N L NL EEL
Sbjct: 754 ---------LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL-EEL 803
Query: 1598 VAVSERKDICNAMGSKLTCEKIVKERYENMMQQQKLTNISKQQAEQISILQTEVERLRMK 1657
S+R + L E E+ + ++++ +K+ +Q I T +E +K
Sbjct: 804 KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKE-----NKRLRQQAEIKDTTLEENNVK 858
Score = 41.6 bits (96), Expect = 0.006
Identities = 104/575 (18%), Positives = 233/575 (40%), Gaps = 88/575 (15%)
Query: 761 EHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKT 820
+ T + ++ + Q E L D++ E +Q+ +E + + SK+ +++++ KSL +
Sbjct: 769 QKTLENSNKKIQQLESELQDLEMENQTLQKNLEE-----LKISSKRLEQLEKENKSLEQE 823
Query: 821 ILNMMEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSYLAEL 880
+ ++ +LE K L + + D + EE I ++E N S +
Sbjct: 824 TSQLEKDKKQLEKENK--------RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGI 875
Query: 881 IKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKE--LERVLQQKKIEAECLKLR 938
KE C ++ + +V+ + +T+ L+E + L+ +++ + KL
Sbjct: 876 YKESCVRLKELEKENKE------LVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLT 929
Query: 939 KEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLE 998
E+ + + L K+R D++ ++ +Y L + L S L LE
Sbjct: 930 HELEK----IGLNKERLLHDEQSTDDS----RYKLLESKL-----------ESTLKKSLE 970
Query: 999 LHSREEKINQIILLKDIIYKVKTVFNNEFDAAYK--QKEFEIARVKERNVRIREIILDLE 1056
+ +EEKI + + + T +N + K +K +E + ++ R+ + +
Sbjct: 971 I--KEEKIAAL----EARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPIS 1024
Query: 1057 LEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKE----------- 1105
E+ W+ E + E L V+D I ++ K+ + K+
Sbjct: 1025 GEDNKWERESQ--ETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQ 1082
Query: 1106 ------HWLLIQDASTRLR---ALMDMMGGVLEVKKEDIL----RMVIPQPAFMAKPDAV 1152
+ +Q+ +T L+ A + + L + ++ +++I Q + + ++V
Sbjct: 1083 ILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV 1142
Query: 1153 WTEEERKQ------FKDYEKKVKELNEERDKYRKSL---EAELKKLQNSIQESTQAFDEH 1203
E E + KD+E K++ L+E + +SL LK +++ + ++
Sbjct: 1143 IKEREDLKSLYDSLIKDHE-KLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR 1201
Query: 1204 LKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAV 1263
+L +++ + E + +++ + E +++ K L R H SQ +
Sbjct: 1202 YNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ----L 1257
Query: 1264 RKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEI 1298
K E L ++ +LL K+ + EFS++
Sbjct: 1258 LKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKL 1292
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 69.3 bits (168), Expect = 3e-11
Identities = 192/930 (20%), Positives = 383/930 (41%), Gaps = 144/930 (15%)
Query: 774 DELVLTDVKKE--IPWIQQKSQEAIKKEVNLFSKKRK------EIKQGIKSLSKTILNMM 825
D+L+ T ++ E I + +++++ + L +KKRK E+K+ I L T+ +
Sbjct: 910 DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 969
Query: 826 EENDKLENIAK-LDQQEFGLDLEELERLHDES---QEEVAKMIKDVEMHN-------LAK 874
+E EN K L ++ GLD E + +L E QE + + D++M AK
Sbjct: 970 KEKHATENKVKNLTEEMAGLD-ETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAK 1028
Query: 875 SYLAELI----------KEECWNSMAVKGRA---LKCFHIPCV-VENFPMKARTVEELKE 920
+ L + + K+ C + K + LK + EN + + KE
Sbjct: 1029 TKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKE 1088
Query: 921 LERVLQQKKIEAE---CLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNY 977
E Q KIE E ++L+K+I E Q+ I++ EE + E K K + +
Sbjct: 1089 FEMSNLQGKIEDEQALAIQLQKKIKELQAR---IEELEEEIEAERASRAKAEKQRSDLSR 1145
Query: 978 LLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFE 1037
L +S S+Q+E++ + E Q + +D+ + T+ + AA ++K +
Sbjct: 1146 ELEEISERLEEAGGATSAQIEMNKKREAEFQK-MRRDL--EESTLQHEATAAALRKKHAD 1202
Query: 1038 -IARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAK 1096
+A + E+ ++ + LE E++ + E D T+ KAK
Sbjct: 1203 SVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETV----------------SKAK 1246
Query: 1097 ELIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTE- 1155
N EK R L D + + + K+E+ R++ A A+ + TE
Sbjct: 1247 ---ANFEK-----------MCRTLEDQLSEI-KTKEEEQQRLINELSAQKAR---LHTES 1288
Query: 1156 -EERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKA 1214
E +Q + + V +L+ + + + +E +L+ ++E T+A L R
Sbjct: 1289 GEFSRQLDEKDAMVSQLSRGKQAFTQQIE----ELKRQLEEETKAKSTLAHALQSARHDC 1344
Query: 1215 EMVTNQ-EELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVC 1273
+++ Q EE + + + + S ++ Y T + EA +K + L
Sbjct: 1345 DLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDA 1404
Query: 1274 KEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDI------LYKLFKRRPRISKQKTHSETTS 1327
+EH + + ++ ++++ ++ +E+ +D+ L K++ K +
Sbjct: 1405 EEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKY 1464
Query: 1328 VVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQKV 1387
EL S K ++ +L K + + E LD L K EN+ +
Sbjct: 1465 EETQAELEASQKESRSLSTELFKVKNAYE------ESLDHL--------ETLKRENKN-L 1509
Query: 1388 KQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEE---KVRFQLNLTIQILLKQ 1444
+Q+ +DL E K + E EKV+++++ EL EE + + ++I L+
Sbjct: 1510 QQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLEL 1569
Query: 1445 GQVELENFQLVLEYSDAI-LINKN---IIEDLNSVIRTQGQKKVASMMESKDVHKRILQI 1500
QV+ E + + E + + + +N ++E + S + ++ S ++ + K+ +
Sbjct: 1570 NQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTL----DAEIRSRNDALRIKKK---M 1622
Query: 1501 EWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEP--NYEALISIQIGIMEQTIAVLD 1558
E + +ME++ N++A + L R+ Q L + + + I Q + EQ +A+++
Sbjct: 1623 EGDLNEMEIQLNHANRQA--AEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQ-LAMVE 1679
Query: 1559 KMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAMGSKLTCEK 1618
+ ++L L + + +A +EL+ SER + + + L K
Sbjct: 1680 RRANLMQAEVEELRASLERTERGRKMA--------EQELLDASERVQLLHTQNTSLINTK 1731
Query: 1619 IVKERYENMMQQQKLTNISKQQAEQISILQ 1648
E T+IS+ Q E I+Q
Sbjct: 1732 KKLE-----------TDISQIQGEMEDIVQ 1750
Score = 45.1 bits (105), Expect = 6e-04
Identities = 47/214 (21%), Positives = 95/214 (44%), Gaps = 14/214 (6%)
Query: 762 HTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKE------IKQGIK 815
+TK+K TD+SQ + + D+ +E ++K+++AI + + +KE +++ K
Sbjct: 1729 NTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788
Query: 816 SLSKTILNMMEENDKLENIA----KLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHN 871
++ +T+ ++ D+ E +A K Q+ + ELE + Q+ + +K + H
Sbjct: 1789 NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHE 1848
Query: 872 LAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQK-KI 930
L +E+ N + ++ K + V+ + +A EE + +K +
Sbjct: 1849 RRVKELTYQTEEDRKNILRLQDLVDK---LQTKVKAYKRQAEEAEEQSNVNLAKFRKLQH 1905
Query: 931 EAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEE 964
E E K R +I E+Q +K R EE
Sbjct: 1906 ELEEAKERADIAESQVNKLRVKSREVHTKVISEE 1939
Score = 36.2 bits (82), Expect = 0.27
Identities = 43/206 (20%), Positives = 95/206 (46%), Gaps = 26/206 (12%)
Query: 780 DVKKEIPWIQQKSQ------EAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLEN 833
D+K+++ +++++ E ++ + + RK +Q + S+ + + +N L N
Sbjct: 1670 DLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLIN 1729
Query: 834 IAK---LDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMA 890
K D + ++E++ + ++E+ K I D M +AE +K+E S
Sbjct: 1730 TKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAM-------MAEELKKEQDTSAH 1782
Query: 891 VKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKIEAECLKLRKEI-------VE 943
++ R K ++ V++ ++ E+L Q +K+EA +L E+ VE
Sbjct: 1783 LE-RMKK--NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVE 1839
Query: 944 AQSGVKLIKQRHEEDDEEEEEEDKTV 969
A G++ ++R +E + EE+ K +
Sbjct: 1840 AVKGLRKHERRVKELTYQTEEDRKNI 1865
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 68.2 bits (165), Expect = 6e-11
Identities = 167/893 (18%), Positives = 364/893 (40%), Gaps = 102/893 (11%)
Query: 740 DKENHYLSTTPKVSVDLGSDSEH-TKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKK 798
D E ++ +++ +G+ + T + +L + E+ ++KK + ++++ Q+ +K+
Sbjct: 1921 DLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEM--KNLKKCVSELEEEKQQLVKE 1978
Query: 799 EVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEELERLHDESQE 858
+ + S+ RKE + I+ K N + L+ + K QQE +++L++ QE
Sbjct: 1979 KTKVESEIRKEYLEKIQGAQKEPGNKSHAKE-LQELLKEKQQE----VKQLQKDCIRYQE 2033
Query: 859 EVA---KMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTV 915
+++ + +K +E E+ KE ++ + +A E K
Sbjct: 2034 KISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKA--------QAELASFKVLLD 2085
Query: 916 EELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDE---EEEEEDKTVKYS 972
+ E RVL A+ LKL+KE+ + VK ++ +ED E E+ EE +
Sbjct: 2086 DTQSEAARVL------ADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKK 2139
Query: 973 NLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYK 1032
N+ L ++ ++ Q+ L+ +++++ Q+ D F +
Sbjct: 2140 NMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
Query: 1033 QKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPW 1092
++ I K+ + + I E E + + + R + + EE+
Sbjct: 2200 DRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEEL--------- 2250
Query: 1093 HKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAF-MAKPDA 1151
K + H+K+ W A T ++ + + KE + ++ + + ++ +
Sbjct: 2251 -KINISRLEHDKQIW--ESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNEL 2307
Query: 1152 VWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDE---HLKRLF 1208
E E K KD + E+ + + +LE +++ + IQ S ++++ L+
Sbjct: 2308 AKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASR 2367
Query: 1209 ERRVKAEMVTNQEELKISNL------AFSLLLDEELSSRE---KFLNNYLTRKQHE---- 1255
E + N +E KI +L A + + E + K L N L++++ E
Sbjct: 2368 ELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVL 2427
Query: 1256 KSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDIL---YKLFKR 1312
+ + +AV K+ + ++ K + + +D SF K S + + I+ +L +R
Sbjct: 2428 EEENKKAVDKTNQLMETLKTIKKENIQQKAQLD-SFVKSMSSLQNDRDRIVGDYQQLEER 2486
Query: 1313 RPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNH 1372
I +K + +L K+ L MD+L++ + + L+
Sbjct: 2487 HLSIILEKDQLIQEAAAENNKL-------KEEIRGLRSHMDDLNSENAKLDA--ELIQYR 2537
Query: 1373 FCMTRRAKVENEQKVK------QKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQ 1426
+ + +++ Q+ + Q+ +L L+++++E E+ +++ R F+ LQ
Sbjct: 2538 EDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFN---ALQ 2594
Query: 1427 EEKVRF-----QLNLTIQILLKQGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQ 1481
EEK L ++I L +Q E L L Y + + + + L S + + Q
Sbjct: 2595 EEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGL-YHAQLKVKEEEVHRL-SALFSSSQ 2652
Query: 1482 KKVASMME-----SKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNE 1536
K++A + E K+ K++ +IE K++ E + L+ A + R +
Sbjct: 2653 KRIAELEEELVCVQKEAAKKVGEIE---DKLKKELKHLHHDAGIM--------RNETETA 2701
Query: 1537 PNYEALISIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQKDIANYAL 1589
A ++ + MEQ + ++ K +K + + + N +D AN L
Sbjct: 2702 EERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEEL 2754
Score = 65.1 bits (157), Expect = 5e-10
Identities = 220/1119 (19%), Positives = 443/1119 (39%), Gaps = 241/1119 (21%)
Query: 738 AMDKEN----HYLSTTPKVSV-DLGSDSEHTKQKASTDLS---------QDELV-LTDVK 782
A++KE H T+ ++S+ D G + + TKQ LS QDEL L
Sbjct: 634 AVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQI 693
Query: 783 KEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILN-------MMEENDKL---- 831
E+ K+QE +K ++ +K+ + Q I+ K N + EE D+L
Sbjct: 694 LELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQV 753
Query: 832 -------ENIAKLDQQEFGL-DLEELERLHDESQEEVAKMIKDVEMHNLA-----KSYLA 878
E A++ Q E L + E RL ESQ ++ + ++H+L+ K
Sbjct: 754 KELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTE-QIHSLSIEAKSKDVKI 812
Query: 879 ELIKEEC------WNSMAVKGRALKCF---HIPCVVENFPMKARTVEELKELERVLQQKK 929
E+++ E ++ + R+L+ V+E +++EL + L QK
Sbjct: 813 EVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQK- 871
Query: 930 IEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYL-LGSLSTDFGV 988
E E K+ + ++E + V+ ++Q EE D++ E + +S + L GV
Sbjct: 872 -ELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTE----ISFSMTEKMVQLNEEKFSLGV 926
Query: 989 DTSLLSSQLELHSREE--KINQIILLKDIIYKVKTVFN--------------NEFDAAYK 1032
+ L QL L SR E K Q+ ++ +K ++ +EFD K
Sbjct: 927 EIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKK 986
Query: 1033 QKEFEIARVK----------ERNVRIREIILDL-----------ELEEAVWQPEFEDCEK 1071
+ E +++ +R R+ E + +L E E + + E+ E
Sbjct: 987 ENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEY 1046
Query: 1072 PERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVK 1131
E+ + + +EI + +K KE+ + H ++ A + +AL+ M L+ K
Sbjct: 1047 SEKCVTSKCQEIEIY--LKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDK 1104
Query: 1132 -------------KEDILRMVIPQPAFMAKPDAV-------------------WTEEERK 1159
+ I++ +I + D+V W E +
Sbjct: 1105 TNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEE 1164
Query: 1160 QFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTN 1219
+ EK+ ++L ++ + S +A LKK QE + E LK+ + + + +
Sbjct: 1165 KILALEKEKEQLQKKLQEALTSRKAILKK----AQEKERHLREELKQQKDDYNRLQEQFD 1220
Query: 1220 QEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTS----EAVRKSRE------- 1268
++ + N+ L ++ RE + Q E ++ E + K+ E
Sbjct: 1221 EQSKENENIG-DQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPV 1279
Query: 1269 -DLDVCKE---HYDNLLA-EDKVMDRSFKKEFSEIPGHQVDILYK--------------L 1309
+ ++C + H ++ A + K + EI +V++ K +
Sbjct: 1280 LESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEV 1339
Query: 1310 FKRRPRISKQKTHSETTSVVPF-GELPGSGKLNKDAFAQLMKA-----------MDELDN 1357
F+ + +I+KQ E+ V E+ K +QL A +DEL
Sbjct: 1340 FQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQK 1399
Query: 1358 I--------------------------SNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKA 1391
+ + + E D + H + +AK E+++++KQ
Sbjct: 1400 LISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAK-EHDERIKQLQ 1458
Query: 1392 ADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTIQILLKQGQVELEN 1451
+L EM + + EE + +Q+I+R ++ ++E ++ +L ++ L +G +E
Sbjct: 1459 VELCEMKQ-KPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIE--- 1514
Query: 1452 FQLVLEYSDAILINKNIIEDLNSVIRTQGQKK------VASMMESKDVHKRILQIEWEHK 1505
+ K+ + D+ S + Q ++K +A + E +D ++ E
Sbjct: 1515 -----------RLTKS-LADVESQVSAQNKEKDTVLGRLALLQEERD------KLITEMD 1556
Query: 1506 KMEMEREDLNQKAWDIQMLF--FSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDKMHKK 1563
+ +E + L+ +++ + D++K + E E+L S +I E T + HK+
Sbjct: 1557 RSLLENQSLSSSCESLKLALEGLTEDKEKLVKE--IESLKSSKIA--EST--EWQEKHKE 1610
Query: 1564 NVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAMGSKLTCEKIVKER 1623
+ + LL+ SN+ + + + +E+ + + + +K EK ++E
Sbjct: 1611 LQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLR---STEANKKETEKQLQEA 1667
Query: 1624 YENMMQ-QQKLTNISKQQAEQISILQTEVERLRMKTFPA 1661
+ M + ++K+ +K + ++I L+ E +RLR + PA
Sbjct: 1668 EQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPA 1706
Score = 63.2 bits (152), Expect = 2e-09
Identities = 180/956 (18%), Positives = 372/956 (38%), Gaps = 173/956 (18%)
Query: 780 DVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQ 839
D KE S ++K+E+ + +K ++LSK ++M E D L
Sbjct: 1708 DTAKECMETLLSSNASMKEEL-------ERVKMEYETLSKKFQSLMSEKDSLS------- 1753
Query: 840 QEFGLDLEELERLHDESQEEVAKM--IKDVEMHNLAKSYLAELIKE-----ECWNSMAVK 892
EE++ L + + V+K ++ E H+ + E + E +S+++
Sbjct: 1754 -------EEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMS 1806
Query: 893 GRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIK 952
R +P P ++ E+ LQQ ++ E +G++ K
Sbjct: 1807 TRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQ----------IDQLKERIAGLEEEK 1856
Query: 953 QRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILL 1012
Q+++E + E E T LL +ST G EL +E++ ++ LL
Sbjct: 1857 QKNKEFSQTLENEKNT---------LLSQISTKDG----------ELKMLQEEVTKMNLL 1897
Query: 1013 KDIIY-------KVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPE 1065
I K+K E D ++ ++A + + + D +++ + + E
Sbjct: 1898 NQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESE 1957
Query: 1066 FEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTR--LRALMDM 1123
++ +K V + E + +K K + I KE+ IQ A ++
Sbjct: 1958 MKNLKK-----CVSELEEEKQQLVKEKTKVESEI---RKEYLEKIQGAQKEPGNKSHAKE 2009
Query: 1124 MGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKK-----VKELNEERDKY 1178
+ +L+ K++++ ++ + K A+ + +F E + KE + ++
Sbjct: 2010 LQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEH 2069
Query: 1179 RKSLEAELKK----LQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLL 1234
RK +AEL L ++ E+ + ++LK E + E V +Q + K +L L
Sbjct: 2070 RKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQ 2129
Query: 1235 DEELSSRE-KFLNNYLTRKQHEKSQTSEAV-------RKSREDLDVCKEHYDNLLAEDKV 1286
EE +E K + L + EK E + K +++ +E+ D+ + +
Sbjct: 2130 AEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQ--- 2186
Query: 1287 MDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFA 1346
+F K S + + ++ + K + S E + + + KD
Sbjct: 2187 -LAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLK----EDNCSVLKDQLR 2241
Query: 1347 QLMKAMDELD-NISNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLL-----EMATF 1400
Q+ M+EL NIS + D +W +K + E +++QK D L E+ +
Sbjct: 2242 QMSIHMEELKINISRLEH--DKQIW-------ESKAQTEVQLQQKVCDTLQGENKELLSQ 2292
Query: 1401 LQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNL--------TIQILLKQGQVELENF 1452
L++ Q E+ ++ EL L+++ +L ++ +++Q + +++N
Sbjct: 2293 LEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS 2352
Query: 1453 QLVLEYSDAIL-INKNIIEDLNSVIRTQGQKKVASMMESKD--VHKRILQIEWEHKKMEM 1509
+ E + L ++ + L+ I + ++K+ S++ K+ + I ++ +H K
Sbjct: 2353 KFSYEQLETDLQASRELTSRLHEEINMK-EQKIISLLSGKEEAIQVAIAELRQQHDKEIK 2411
Query: 1510 EREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDKMHKKNVENCK 1569
E E+L L + L E N +A + Q + L + K+N++
Sbjct: 2412 ELENL---------LSQEEEENIVLEEENKKA-----VDKTNQLMETLKTIKKENIQQKA 2457
Query: 1570 KL---LKKLGKFSNQKD--IANY----------------------ALSCNLREELVAVSE 1602
+L +K + N +D + +Y A + L+EE+ +
Sbjct: 2458 QLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRS 2517
Query: 1603 RKDICNAMGSKLTCEKIVKERYENMM------QQQKLTNISKQQAEQISILQTEVE 1652
D N+ +KL E I N + QQ++L + QQ +++ ++E
Sbjct: 2518 HMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLE 2573
Score = 45.4 bits (106), Expect = 4e-04
Identities = 162/837 (19%), Positives = 324/837 (38%), Gaps = 108/837 (12%)
Query: 718 GHLASEILDYYQKLLISLSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQDELV 777
G +E+ Y L + M+++ ++ + K +L S + K + S L
Sbjct: 353 GQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQ 412
Query: 778 LTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKL---ENI 834
+ I ++ + Q+ KE++ F R ++Q + + ++ E + ENI
Sbjct: 413 AVQSAQTIQQLEDQLQQK-SKEISQFLN-RLPLQQHETASQTSFPDVYNEGTQAVTEENI 470
Query: 835 AKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLA---KSYLAELIKEECWNSMAV 891
A L ++ + ELE E+ A ++ +E+ L + +++ E N
Sbjct: 471 ASLQKR-----VVELEN------EKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGE 519
Query: 892 KGRALKCFHIPCVVENFPMKARTVEELKE--LERVLQQKKIEAECLKLRKEIVEAQSGVK 949
R + I + ++ + EE + LE QK E L L E+ EAQ +
Sbjct: 520 ADREVSEISIVDIANK---RSSSAEESGQDVLENTFSQKHKELSVLLL--EMKEAQEEIA 574
Query: 950 LIK-----QRHEEDDEE--EEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLL---SSQLEL 999
+K +R EE D E +++E K ++ + + D G D L+ S L
Sbjct: 575 FLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPA 634
Query: 1000 HSREE-------KINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREII 1052
+E+ + ++ I L D ++K+ + + + E R++ I
Sbjct: 635 VEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELE-RLKSQI 693
Query: 1053 LDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQD 1112
L+LEL Q +E + L + +EI+ +LI +K +
Sbjct: 694 LELELNFHKAQEIYE------KNLDEKAKEIS---------NLNQLIEEFKKN----ADN 734
Query: 1113 ASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELN 1172
S+ AL + +L KE L MV A + + + E ER++ DYE + N
Sbjct: 735 NSSAFTALSEERDQLLSQVKE--LSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDN 792
Query: 1173 EERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSL 1232
++ SL E K I+ D+ + E+ + +Q + K S +
Sbjct: 793 LLTEQIH-SLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGA 851
Query: 1233 LLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFK 1292
+SS+ + L+ L++K+ E ++ + + + + D++ ++ + + +V + SF
Sbjct: 852 ERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEE--KDQQVTEISFS 909
Query: 1293 KEFSEIPGHQ----VDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQL 1348
+ ++ + + K K + + + ++ V E+ K N D +
Sbjct: 910 MTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPA 969
Query: 1349 MKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEEE 1408
+ E + D L K ENEQ+ ++ A L+ LQ+ E
Sbjct: 970 GQISKE-----ELQHEFDLL-----------KKENEQRKRKLQAALINRKELLQRVSRLE 1013
Query: 1409 EKVQQEIERVFHELILLQEEKVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKNI 1468
E++ L E K L+ T ++G+VE + EYS+ + +K
Sbjct: 1014 EELAN----------LKDESKKEIPLSET-----ERGEVEEDKEN--KEYSEKCVTSK-- 1054
Query: 1469 IEDLNSVIR-TQGQKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQML 1524
+++ ++ T +K+V KD+ +++ E ++ + L K I +L
Sbjct: 1055 CQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLL 1111
Score = 43.5 bits (101), Expect = 0.002
Identities = 123/624 (19%), Positives = 252/624 (40%), Gaps = 103/624 (16%)
Query: 720 LASEILDYYQKL--LISLSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQDELV 777
L +E++ Y + L +I++ + K+ +V + + E+ K L + E
Sbjct: 2529 LDAELIQYREDLNQVITIKDSQQKQ------LLEVQLQQNKELENKYAKLEEKLKESEEA 2582
Query: 778 LTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKL 837
D+++ +Q++ Q+ SK+ + +K I L++ + + EE A+L
Sbjct: 2583 NEDLRRSFNALQEEKQD--------LSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQL 2634
Query: 838 DQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALK 897
+E ++ L L SQ+ +A++ +++ + I+++ +K
Sbjct: 2635 KVKEE--EVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDK------LKKELKH 2686
Query: 898 CFHIPCVVENFPMKARTVEE-LKELERVLQQKKIEAECLKLRKE----IVEAQS-GVKLI 951
H ++ N + T EE + EL R L + +E + L + KE + QS G +
Sbjct: 2687 LHHDAGIMRN---ETETAEERVAELARDLVE--MEQKLLMVTKENKGLTAQIQSFGRSMS 2741
Query: 952 KQRHEEDDEEEEEEDKTVKYSNLPNYLL-----GSLSTDFGVDTSLLSSQLELHSREE-- 1004
++ D EE ++ KY L G L+ + D L + ++S EE
Sbjct: 2742 SLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRER--DALLSETAFSMNSTEENS 2799
Query: 1005 -----KINQIILLKDIIYKVKTVFNNEFDAAYKQ-KEFEIARVKERNVRIREIILDLELE 1058
K+NQ +L KD + +++ + +Y Q + F A +N R L ELE
Sbjct: 2800 LSHLEKLNQQLLSKD---EQLLHLSSQLEDSYNQVQSFSKAMASLQNERDH---LWNELE 2853
Query: 1059 EAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLR 1118
+ F E+ ++ Q T+ ++ KA + N D L+
Sbjct: 2854 K------FRKSEEGKQRSAAQPS--TSPAEVQSLKKAMSSLQN----------DRDRLLK 2895
Query: 1119 ALMDMMGGVLEVKKEDI----LRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEE 1174
L ++ L++ +E L+ + + K + EE R++ ++ ++ +L E
Sbjct: 2896 ELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRME 2955
Query: 1175 RDKYR--------------KSLEAELKKLQNSIQE--STQAFDEHLKRLFERRVKAEMVT 1218
+ + + +L LQN I+E S+ + + LK ++R+ E
Sbjct: 2956 KSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSA 3015
Query: 1219 NQE---------ELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSRED 1269
+ + EL + L SL + R + LN+ ++ EK+ S + + +
Sbjct: 3016 SPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQS 3075
Query: 1270 LDVCKEHYDNLLAEDKVMDRSFKK 1293
L ++HY +LL V+++ ++
Sbjct: 3076 LRENQQHYGDLLNHCAVLEKQVQE 3099
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 67.4 bits (163), Expect = 1e-10
Identities = 171/863 (19%), Positives = 329/863 (38%), Gaps = 152/863 (17%)
Query: 746 LSTTPKVSVDLGSDSEHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSK 805
L T K DL ++ +K + LS++ L+ +E Q+ Q+A+ + SK
Sbjct: 292 LHETLKQCQDLKTEKSQMDRKIN-QLSEENGDLSFKLREFASHLQQLQDALNELTEEHSK 350
Query: 806 KRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIK 865
+E + L K + +++ LE ++ Q + E L +L D +E +++
Sbjct: 351 ATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLG 410
Query: 866 DVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVL 925
DV K A L N ++AR E+ E ER
Sbjct: 411 DVLQLETLKQEAATL-----------------------AANNTQLQARV--EMLETERGQ 445
Query: 926 QQKKI-------EAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDK--TVKYSNLPN 976
Q+ K+ E E +L I + QS + + Q EE ++ + T + ++L +
Sbjct: 446 QEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTS 505
Query: 977 YLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKEF 1036
L +T D L + + ++ ++ Q + ++ + + ++ KQKE
Sbjct: 506 ELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQ 565
Query: 1037 EIARVKER---------------------NVRIREIILD----LELEEA----VWQPEFE 1067
++ V E+ ++R R+ L LE E+A + Q + +
Sbjct: 566 QLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQ 625
Query: 1068 DC----------------EKPERTLVVQDEEITAHKHIKPWHKAKELI------------ 1099
EK E + V++ + + H+A+ +
Sbjct: 626 VANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQ 685
Query: 1100 -------VNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAV 1152
V EK+ +Q+ L+ + + G LE +K + Q +++ A
Sbjct: 686 KATEKERVAQEKDQ---LQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKA- 741
Query: 1153 WTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRV 1212
E R + ++++ KEL EER RK LEA L++L + Q T+ L +
Sbjct: 742 ---ETRSLVEQHKRERKELEEERAG-RKGLEARLQQLGEAHQAETEVLRRELAEAMAAQH 797
Query: 1213 KAEMVTNQEELKISNLAFSLLLDEELSSREKFLNN------YLTRKQHEKSQTSEAVRKS 1266
AE Q L+ E + RE++ ++ Y Q + E K+
Sbjct: 798 TAESECEQ------------LVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKA 845
Query: 1267 REDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISK-------- 1318
R++L KE + + ++ + E +E+ + L ++ ++ R K
Sbjct: 846 RQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTL 905
Query: 1319 QKTHSETTSVVPFGE--LPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMT 1376
Q+ + T+ V E + +G+ + A +L+K + PE L+ FC T
Sbjct: 906 QEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGD--RQPEWLEEQQGRQFCST 963
Query: 1377 RRAKVENEQKVKQKAADL--LEMATFLQKRVEEEEKVQQE-------IERVFHELILLQE 1427
+ A E++ +Q +L L A + ++EE+ QQE ER + L E
Sbjct: 964 QAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALE 1023
Query: 1428 EKVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQKKVASM 1487
+ R +L + +Q L + +VE Q L ++ L K E + + + A +
Sbjct: 1024 KAARAELEMRLQNALNEQRVEFATLQEALAHA---LTEK---EGKDQELAKLRGLEAAQI 1077
Query: 1488 MESKDVHKRILQIEWEHKKMEME 1510
E +++ + + Q++ + K E E
Sbjct: 1078 KELEELRQTVKQLKEQLAKKEKE 1100
Score = 45.8 bits (107), Expect = 3e-04
Identities = 132/690 (19%), Positives = 277/690 (40%), Gaps = 110/690 (15%)
Query: 824 MMEENDKLENIAKLDQQEFGL--DLEELERLHDESQEEVAKMIKDVEMHNLAKSYLAELI 881
+ E+ K + +AKL E +LEEL + + +E++AK K+ + A+S A
Sbjct: 1056 LTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRT 1115
Query: 882 KEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQ----------QKKIE 931
+ A++ K + + +A ++E E ER + Q ++E
Sbjct: 1116 EPTGPKLEALRAEVSK---LEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLE 1172
Query: 932 AECLKL---RKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGV 988
+ +L + + AQ + + + ++ + E+E V SL +
Sbjct: 1173 EKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEE 1232
Query: 989 DTSLLSSQ-LELHSREEKINQIILLKDI----------IYKVKTVFNN----EFDAAYKQ 1033
+ S+L+ Q LE +++ ++++ + + + +T N+ E +A ++
Sbjct: 1233 EVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALRE 1292
Query: 1034 K------EFEIARVKERNVRIR-----EIILDLELEEAVWQPEFEDCEKPERTLVVQD-- 1080
+ E E RV N+R E +L E WQ +F E+ TL ++
Sbjct: 1293 EVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTS 1352
Query: 1081 -----EEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDI 1135
E+ KH+ +A++ EK H ++ + +A + +L ++E
Sbjct: 1353 TQALVSELLPAKHLCQQLQAEQAAA--EKRHREELEQSK---QAAGGLRAELLRAQRE-- 1405
Query: 1136 LRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQE 1195
L +IP R++ + E+ ++L E+ Y + L LKK + E
Sbjct: 1406 LGELIPL---------------RQKVAEQERTAQQLRAEKASYAEQLSM-LKKAHGLLAE 1449
Query: 1196 STQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHE 1255
+ E +NL L E +REK++ +
Sbjct: 1450 ENRGLGER----------------------ANLGRQFLEVELDQAREKYVQELAAVRADA 1487
Query: 1256 KSQTSEAVRKSRE---DLDVCKEHYDNLLAEDKVMD--RSFKKEFSEIPGH--QVDILYK 1308
+++ +E R+++ +L+V Y+ A+ KV++ + F++E ++ Q+++ +
Sbjct: 1488 ETRLAEVQREAQSTARELEVMTAKYEG--AKVKVLEERQRFQEERQKLTAQVEQLEVFQR 1545
Query: 1309 -LFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDP 1367
K+ +SK+ S+ S V +L ++ + + +L+ + +
Sbjct: 1546 EQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQ 1605
Query: 1368 LVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELI---L 1424
++ +AK + K KQ+ +L E L++ +E ++++ E ER+ HEL L
Sbjct: 1606 AAEHYKLQMEKAKTHYDAK-KQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGL 1664
Query: 1425 LQEEKVRFQLNLTIQILLKQGQVELENFQL 1454
+E + +LT Q+ + QV + QL
Sbjct: 1665 KTKEAEQTCRHLTAQVRSLEAQVAHADQQL 1694
Score = 44.7 bits (104), Expect = 8e-04
Identities = 94/492 (19%), Positives = 192/492 (39%), Gaps = 58/492 (11%)
Query: 795 AIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEELERLHD 854
++++EV++ +++ E + K L + ++ E++ KLE +L Q E +
Sbjct: 1229 SLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSS 1288
Query: 855 ESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKART 914
+EEV + ++ E +A L + + + + + G+ LK + E F K +
Sbjct: 1289 ALREEVQSLREEAEKQRVASENLRQELTSQAERAEEL-GQELKAWQ-----EKFFQKEQA 1342
Query: 915 VEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNL 974
+ L +LE Q + +E L + + Q+ ++RH E+ E+ ++
Sbjct: 1343 LSTL-QLEHTSTQALV-SELLPAKHLCQQLQAEQAAAEKRHREELEQSKQ---------- 1390
Query: 975 PNYLLGSLSTDFGVDTSLLSSQLELH---------SREEKINQIILLKDIIYKVKTVFNN 1025
G+ LL +Q EL + +E+ Q + + Y +
Sbjct: 1391 ---------AAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441
Query: 1026 EFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITA 1085
+ ++ + + E+ LD E+ V + + R VQ E +
Sbjct: 1442 KAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQST 1501
Query: 1086 HKHIKPW---HKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQ 1142
+ ++ ++ ++ V E++ + Q+ +L A ++ LEV + + + V
Sbjct: 1502 ARELEVMTAKYEGAKVKVLEERQRF---QEERQKLTAQVEQ----LEVFQREQTKQVEEL 1554
Query: 1143 PAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDE 1202
+A D +++K K V+ E + + L+A+L +LQ + + QA E
Sbjct: 1555 SKKLADSDQASKVQQQKL-----KAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQA-AE 1608
Query: 1203 HLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEA 1262
H K E+ Q+ ++ SL E+L K L R HE Q A
Sbjct: 1609 HYKLQMEKAKTHYDAKKQQNQELQEQLRSL---EQLQKENKELRAEAERLGHELQQ---A 1662
Query: 1263 VRKSREDLDVCK 1274
K++E C+
Sbjct: 1663 GLKTKEAEQTCR 1674
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 67.4 bits (163), Expect = 1e-10
Identities = 132/637 (20%), Positives = 265/637 (41%), Gaps = 91/637 (14%)
Query: 718 GHLASEILDYYQKLLISLSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQDELV 777
G + D + L + + +K NH L + K + + +S+ +
Sbjct: 1615 GSMVQAKADLQEALRLGETEVTEKCNHIREVK-----SLLEELSFQKGELNVQISERKTQ 1669
Query: 778 LTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIK-------------QGIK--------S 816
LT +K+EI +K +E ++ + SK + E+K QG+K
Sbjct: 1670 LTLIKQEI----EKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSE 1725
Query: 817 LSKTILNMMEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSY 876
L KT + ++EE +LEN+ ++ QQ+ G ++E ++L + + E+ +M +
Sbjct: 1726 LEKTQVAVLEEKLELENLQQISQQQKG-EIEWQKQLLERDKREIERMTAESRALQSCVEC 1784
Query: 877 LA---ELIKEEC--WNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQK--K 929
L+ E ++E+C W + + + + EN M+ +E+L+ R LQQ+ +
Sbjct: 1785 LSKEKEDLQEKCDIWEKKLAQTKRV----LAAAEENSKMEQSNLEKLELNVRKLQQELDQ 1840
Query: 930 IEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNY----------LL 979
+ + L L +I Q + ++++ E + +EE + NL +L
Sbjct: 1841 LNRDKLSLHNDISAMQ---QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVL 1897
Query: 980 GSLSTDFGVDTSLLSSQLELHSREE--KINQIILLKDIIYKVKTVFNNE---FDAAYKQK 1034
S T D S +++ E +EE K Q+ +L++ I + K + F K++
Sbjct: 1898 LSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKER 1957
Query: 1035 EFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHK 1094
E E ++++ V ++E LE E + + + ++ +E + + + W +
Sbjct: 1958 ESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLS---KVLAAEERVRTLQEEERWCE 2014
Query: 1095 AKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKE-DILRMVIPQPAFMAKPDAVW 1153
+ E ++ K + S R + L++ G +L ++KE D +R F +
Sbjct: 2015 SLEKTLSQTK------RQLSEREQQLVEKSGELLALQKEADSMR-----ADFSLLRNQFL 2063
Query: 1154 TEEERKQFKDYEKKVKELNEERDKYRKSLEAEL--KKLQNS-IQESTQAFDEHLKRLFER 1210
TE K EK+V L E R LE L +K +NS IQ+ + + ER
Sbjct: 2064 TER-----KKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHER 2118
Query: 1211 RVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNYL-TRKQHEKSQTSEAVRKSRE- 1268
+ NQ + + + L + ++L R+ +++ + T K K + +++ +
Sbjct: 2119 ARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQF 2178
Query: 1269 ------DLDVCKEHYDNLLAEDKVMDRSFKKEFSEIP 1299
DL+ E +NL E + + + +E P
Sbjct: 2179 LPELPADLEAILERNENLEGELESLKENLPFTMNEGP 2215
Score = 59.3 bits (142), Expect = 3e-08
Identities = 147/805 (18%), Positives = 335/805 (41%), Gaps = 138/805 (17%)
Query: 761 EHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNL---FSKKRKEIKQGIKSL 817
E T K ++L + + +L + + E+ ++K++ A++K + + + ++ +
Sbjct: 1425 EKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRA 1484
Query: 818 SKTILNMMEENDKLENIA---------KLDQQEF-----------GLDLEELERLHDESQ 857
+T +N+++ + +L ++ K+ Q+E D + L + ++
Sbjct: 1485 QETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLT 1544
Query: 858 EEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEE 917
EE+ K+ KD+EM + + +++KE + + ++ + + + V + +E
Sbjct: 1545 EELQKLQKDIEMAERNEDHHLQVLKE---SEVLLQAKRAELEKLKSQVTS------QQQE 1595
Query: 918 LKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNY 977
+ L+R L KK E L+ +V+A++ ++ + E + E+ + VK
Sbjct: 1596 MAVLDRQLGHKKEELHL--LQGSMVQAKADLQEALRLGETEVTEKCNHIREVK------- 1646
Query: 978 LLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFE 1037
SL + L+ Q+ E+ Q+ L+K E + + +
Sbjct: 1647 ---SLLEELSFQKGELNVQI-----SERKTQLTLIK-----------QEIEKEEENLQVV 1687
Query: 1038 IARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKE 1097
+ ++ + ++ I+ L+LE Q L +Q ++ + + +
Sbjct: 1688 LRQMSKHKTELKNILDMLQLENHELQ-----------GLKLQHDQRVSEL------EKTQ 1730
Query: 1098 LIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEE 1157
+ V EK +Q S + + ++ +LE K +I RM A + + + E+E
Sbjct: 1731 VAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKE 1790
Query: 1158 RKQFK--DYEKKV---KELNEERDKYRKSLEAELKKLQNSIQESTQAFDE--HLKRLFER 1210
Q K +EKK+ K + ++ K ++ L+KL+ ++++ Q D+ K
Sbjct: 1791 DLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHN 1850
Query: 1211 RVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLN----NYLTRKQHEKSQTSEAVRKS 1266
+ A QE+ + N L EEL++ + LN + L +H+ SE R
Sbjct: 1851 DISAMQQQLQEKREAVN-----SLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTR-L 1904
Query: 1267 REDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYK--LFKRRPRISKQKTHSE 1324
++D+ +++ E++ + + +EI +++ ++ + +F+R + + +
Sbjct: 1905 QKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKL 1964
Query: 1325 TTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPL---------VWNHFCM 1375
TS V E +L K+ Q K L + E + L +
Sbjct: 1965 ETSKVTLKE--QQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQ 2022
Query: 1376 TRRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLN 1435
T+R E EQ++ +K+ +LL + Q+E + + + LL+ + + +
Sbjct: 2023 TKRQLSEREQQLVEKSGELLAL--------------QKEADSMRADFSLLRNQFLTERKK 2068
Query: 1436 LTIQILLKQGQVELENFQLVLEYSDAILINKNIIEDL--NSVIRTQGQKKVASM-MESKD 1492
Q+ + ++++ QL KN++E NS I QK++A++ + ++D
Sbjct: 2069 AEKQVASLKEALKIQRSQL----------EKNLLEQKQENSCI----QKEMATIELVAQD 2114
Query: 1493 VHKRILQIEWEHKKMEMEREDLNQK 1517
H+R ++ E +M+ E +L ++
Sbjct: 2115 NHERARRLMKELNQMQYEYTELKKQ 2139
Score = 53.5 bits (127), Expect = 2e-06
Identities = 163/872 (18%), Positives = 353/872 (40%), Gaps = 155/872 (17%)
Query: 846 LEELERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVV 905
LEE+ERL + ++ KMI+ E+ + +L E+ ++ N ++LK
Sbjct: 269 LEEVERLERDLEK---KMIETEELKSKQTRFLEEIKNQDKLN------KSLK-------- 311
Query: 906 ENFPMKARTVEELKE----LERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDD-- 959
E ++ ++ EELK +L+QK IE ++ +E + I + E +
Sbjct: 312 EEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYY 371
Query: 960 -EEEEEEDKTVK---YSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKI-NQIILLKD 1014
E E DK Y Y +T+ + S + Q++ +E++ N + L+
Sbjct: 372 PSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRG 431
Query: 1015 IIYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPER 1074
+ D + KE +I+ + R + + I EK E+
Sbjct: 432 ---------HTPLDTQLEDKEKKISAAQTRLSELHDEI-----------------EKAEQ 465
Query: 1075 TLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKED 1134
++ EE K +A +L E LL + S RL+ + + L+++
Sbjct: 466 QILRATEEF------KQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLE--- 516
Query: 1135 ILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKY------RKSLEAELKK 1188
L+M + K +K+ KD + + L+ + K+ + E +L
Sbjct: 517 -LQMEKQKQEIAGK---------QKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDI 566
Query: 1189 LQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNY 1248
+ Q+ DE L R+ + E+ +E+L +A + L ++L L Y
Sbjct: 567 MNKQYQQLESRLDEILSRIAKET--EEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEY 624
Query: 1249 LTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMD------RSFKKEFSEIPGHQ 1302
L + + +Q RK R++ + + + E ++ + +KE +E+
Sbjct: 625 LGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESAL 684
Query: 1303 VDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLN-KDAFAQLMKAMDELDNISNM 1361
+ + S Q+T + ++ E +LN +DA A +K +EL+ ++ +
Sbjct: 685 QE------QHEVNASLQQTQGDLSAY----EAELEARLNLRDAEANQLK--EELEKVTRL 732
Query: 1362 PEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHE 1421
+ + + A +K +Q + L A F +++ +E ++ +++ + +
Sbjct: 733 TQ-----------LEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDD 781
Query: 1422 LILLQEEKVRFQ--LNLTIQILLKQGQVELENFQLVLE----------YSDAILINKNII 1469
LL+++ FQ LN + L++ +V +L + +S + ++ K++
Sbjct: 782 NNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLA 841
Query: 1470 E---DLNSVI-RTQGQKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQ---KAWDIQ 1522
+ + ++ R++ ++ A + E K + LQ E K+ +E+ Q +A + +
Sbjct: 842 DLQKQFSEILARSKWERDEAQVRERKLQEEMALQQE----KLATGQEEFRQACERALEAR 897
Query: 1523 MLFFSRDRQKYLNEPNYEA-LISIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQ 1581
M F R + + + E + + ME+ + D ++ E +++L +L + +
Sbjct: 898 MNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKK 957
Query: 1582 KDIAN-------YALSCNLRE--ELVAVSER---------KDICNAMGSKLTCEKIVKER 1623
K + + + L L++ + VA S++ KD ++ T KI +ER
Sbjct: 958 KKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHG--TVMKINQER 1015
Query: 1624 YENMMQQQKLTNISKQQAEQISILQTEVERLR 1655
E + + ++ + + Q A ++ + E+E L+
Sbjct: 1016 AEELQEAERFSRKAAQAARDLTRAEAEIELLQ 1047
Score = 53.5 bits (127), Expect = 2e-06
Identities = 163/784 (20%), Positives = 321/784 (40%), Gaps = 207/784 (26%)
Query: 915 VEELKELERVLQQKKIEAECLKL-----RKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTV 969
V L+++ + L+ KK E ++ KE+ E + + Q + + E EE +TV
Sbjct: 1325 VSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTV 1384
Query: 970 -KYSNLPNYLLG---SLSTDFGVDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNN 1025
K +++ G SL T+ ++ SL E+ +++I ++ + K ++
Sbjct: 1385 QKRQQQKDFIDGNVESLMTELEIEKSL-------KHHEDIVDEIECIEKTLLKRRSELR- 1436
Query: 1026 EFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITA 1085
E D + E E++ KE+ E D + ++ Q E D E+ ER
Sbjct: 1437 EADRLLAEAESELSCTKEKTKNAVEKFTDAK--RSLLQTE-SDAEELER----------- 1482
Query: 1086 HKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLE--VKKEDILRMVIPQP 1143
+A+E VN K A +LR+L + + +K+E+IL+ +
Sbjct: 1483 --------RAQETAVNLVK--------ADQQLRSLQADAKDLEQHKIKQEEILKEI---N 1523
Query: 1144 AFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEH 1203
+A D+ F+ KK ++L EE L+KLQ I+ + + D H
Sbjct: 1524 KIVAAKDS--------DFQCLSKKKEKLTEE-----------LQKLQKDIEMAERNEDHH 1564
Query: 1204 LKRLFE------------RRVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTR 1251
L+ L E ++K+++ + Q+E+ + LD +L +++ L+
Sbjct: 1565 LQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAV--------LDRQLGHKKEELHLLQGS 1616
Query: 1252 KQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFK 1311
K+ EA+R ++ H R K E+ + ++ ++ +
Sbjct: 1617 MVQAKADLQEALRLGETEVTEKCNHI-----------REVKSLLEELSFQKGELNVQISE 1665
Query: 1312 RRPRIS--KQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLV 1369
R+ +++ KQ+ E ++ + Q+ K EL NI +M + +
Sbjct: 1666 RKTQLTLIKQEIEKEEENL-------------QVVLRQMSKHKTELKNILDMLQ-----L 1707
Query: 1370 WNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEK 1429
NH + K++++Q RV E EK Q + + EEK
Sbjct: 1708 ENH--ELQGLKLQHDQ------------------RVSELEKTQ----------VAVLEEK 1737
Query: 1430 VRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKNIIED--LNSVIRTQGQKKVASM 1487
+ + +Q + +Q + E+E + +LE D I + E L S + ++K +
Sbjct: 1738 LELE---NLQQISQQQKGEIEWQKQLLE-RDKREIERMTAESRALQSCVECLSKEK-EDL 1792
Query: 1488 MESKDV-------HKRILQIEWEHKKME---MEREDLNQKAWDIQMLFFSRDRQKYLNEP 1537
E D+ KR+L E+ KME +E+ +LN + ++ +RD+ N+
Sbjct: 1793 QEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHND- 1851
Query: 1538 NYEALISIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNL-REE 1596
I M+Q + K+ N S Q+++AN NL +++
Sbjct: 1852 ---------ISAMQQQL-----QEKREAVN-----------SLQEELANVQDHLNLAKQD 1886
Query: 1597 LVAVSERKDICNAMGSKLTCEKIVKE---RYENMMQQQKLTNISKQQAEQISILQTEVER 1653
L+ ++ +D+ + ++L +K + E R+E+ ++++ +KQQ Q+ +LQ E+E
Sbjct: 1887 LLHTTKHQDVLLSEQTRL--QKDISEWANRFEDCQKEEE----TKQQ--QLQVLQNEIEE 1938
Query: 1654 LRMK 1657
++K
Sbjct: 1939 NKLK 1942
Score = 48.5 bits (114), Expect = 5e-05
Identities = 173/895 (19%), Positives = 356/895 (39%), Gaps = 155/895 (17%)
Query: 853 HDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKA 912
H + EV+++ +D+ H +K +EE W + + + + +++ +
Sbjct: 1318 HHNLENEVSRL-EDIMQHLKSKK------REERWMRASKRQSEKEMEELHHNIDDLLQEK 1370
Query: 913 RTVE-ELKELERVLQQKK-----------------------------------IEAECLK 936
+++E E++EL R +Q+++ IE LK
Sbjct: 1371 KSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLK 1430
Query: 937 LRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVD------- 989
R E+ EA L + E +E+ ++ K+++ LL + S ++
Sbjct: 1431 RRSELREADR--LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETA 1488
Query: 990 TSLLSSQLELHS--------REEKINQIILLKDIIYKVKTVFNNEFDAAYKQKE--FEIA 1039
+L+ + +L S + KI Q +LK+ I K+ +++F K+KE E
Sbjct: 1489 VNLVKADQQLRSLQADAKDLEQHKIKQEEILKE-INKIVAAKDSDFQCLSKKKEKLTEEL 1547
Query: 1040 RVKERNVRIREIILDLELE-----EAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHK 1094
+ ++++ + E D L+ E + Q + + EK + + Q +E+
Sbjct: 1548 QKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMA---------- 1597
Query: 1095 AKELIVNHEKEHWLLIQDASTRLRALMD---MMGGVLEVKKEDILRMV---IPQPAFMAK 1148
+ + H+KE L+Q + + +A + +G +K + +R V + + +F
Sbjct: 1598 VLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKG 1657
Query: 1149 PDAVWTEEERKQF----KDYEKKVKELN---EERDKYRKSLEAELKKLQNSIQESTQAFD 1201
V E + Q ++ EK+ + L + K++ L+ L LQ E
Sbjct: 1658 ELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKL 1717
Query: 1202 EHLKRLFERRVKAEMVTNQEELKISNL-------AFSLLLDEELSSREKFLNNYLTRKQH 1254
+H +R+ E K ++ +E+L++ NL + ++L R+K +T +
Sbjct: 1718 QHDQRVSELE-KTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESR 1776
Query: 1255 EKSQTSEAVRKSREDLDVCKEHYDNLLAEDK----VMDRSFKKEFSEIPGHQVDILYKLF 1310
E + K +EDL + ++ LA+ K + + K E S + ++++ KL
Sbjct: 1777 ALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNV-RKLQ 1835
Query: 1311 KRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVW 1370
+ ++++ K L+ D A + ++ + ++++ E L V
Sbjct: 1836 QELDQLNRDKL-----------------SLHNDISAMQQQLQEKREAVNSLQEEL-ANVQ 1877
Query: 1371 NHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEE----EEKVQQEIERVFHELILLQ 1426
+H + AK + K + LL T LQK + E E Q+E E +L +LQ
Sbjct: 1878 DHLNL---AKQDLLHTTKHQDV-LLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQ 1933
Query: 1427 EEKVRFQLNLTIQ-ILLKQGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQKKVA 1485
E +L L Q ++ ++ Q E E+ + LE S L K L + Q K
Sbjct: 1934 NEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTL--KEQQHQLEKELTDQKSKLDQ 1991
Query: 1486 SMMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISI 1545
+ + +R+ ++ E + E + L+Q + +R++ L E + E L+++
Sbjct: 1992 VLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLS------EREQQLVEKSGE-LLAL 2044
Query: 1546 QIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKD 1605
Q + A + + + KK K++ I L NL E+ ++++
Sbjct: 2045 Q-KEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQ-----KQEN 2098
Query: 1606 ICNAMGSKLTCEKIVKERYENM--------MQQQKLTNISKQQAEQISILQTEVE 1652
C T E + ++ +E Q + T + KQ A Q + + ++E
Sbjct: 2099 SC-IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQME 2152
Score = 44.3 bits (103), Expect = 0.001
Identities = 130/652 (19%), Positives = 256/652 (39%), Gaps = 117/652 (17%)
Query: 725 LDYYQKLLISLSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDLSQDELVLTDVKKE 784
LD K L S +D+ LS K + ++ E Q ++ +E + D++
Sbjct: 564 LDIMNKQYQQLESRLDE---ILSRIAKETEEIKDLEE---QLTEGQIAANEALKKDLEGV 617
Query: 785 IPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGL 844
I +Q+ IK + + ++++ ++L + + + +E D+LE +A +D +
Sbjct: 618 ISGLQEYLG-TIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVA-MDAENMRK 675
Query: 845 DLEELERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCV 904
+L ELE E E A + + +Y AEL E N + LK
Sbjct: 676 ELAELESALQEQHEVNASL---QQTQGDLSAYEAEL--EARLNLRDAEANQLK------- 723
Query: 905 VENFPMKARTVEELKELERV--LQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEE 962
EEL+++ R+ L+Q ++AE K R+ + A Q EE ++E
Sbjct: 724 -----------EELEKVTRLTQLEQSALQAELEKERQALKNALGKA----QFSEEKEQEN 768
Query: 963 EEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQL----ELHSREEKINQIILL------ 1012
E +K+ N LL DF + + L E+ +R +++ + + L
Sbjct: 769 SELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMN 828
Query: 1013 ----KDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEF-E 1067
D++ K +F + ++E + R +++E + + + A Q EF +
Sbjct: 829 IHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQ 888
Query: 1068 DCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEK-EHWLLIQDASTRLRALMDMMGG 1126
CE +A E +N +K +H IQ + L + +
Sbjct: 889 ACE-----------------------RALEARMNFDKRQHEARIQQMENEIHYLQENLKS 925
Query: 1127 VLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAEL 1186
+ E++ L++ Q A K E Q ++ EKK K + + + L+ EL
Sbjct: 926 MEEIQGLTDLQL---QEADEEK------ERILAQLRELEKKKKLEDAKSQEQVFGLDKEL 976
Query: 1187 KKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISN---LAFSLLLDEELSSREK 1243
KKL+ ++ S ++ AE+ +++LK + + + EEL E+
Sbjct: 977 KKLKKAVATS------------DKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAER 1024
Query: 1244 FLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQV 1303
F + +Q + + ++ ++++ + NLL + R ++ G
Sbjct: 1025 F--------SRKAAQAARDLTRAEAEIELLQ----NLLRQKGEQFRLEMEKTGVGTGANS 1072
Query: 1304 DILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDEL 1355
+L ++ K + +Q+T V L +G NK F +++ + EL
Sbjct: 1073 QVL-EIEKLNETMERQRTEIARLQNV----LDLTGSDNKGGFENVLEEIAEL 1119
Score = 38.9 bits (89), Expect = 0.042
Identities = 99/495 (20%), Positives = 205/495 (41%), Gaps = 87/495 (17%)
Query: 1180 KSLEAELKKLQNSIQESTQAFD-EHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEEL 1238
+SLE + Q+ QE+ + F E ++RL ER ++ +M+ EELK F EE+
Sbjct: 248 ESLEGQPVTTQDR-QEAFERFSLEEVERL-ERDLEKKMIET-EELKSKQTRFL----EEI 300
Query: 1239 SSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKV-MDRSFKKEFS- 1296
+++K LN L + + Q+ E ++ DL+ E LL + + + R+ +K++
Sbjct: 301 KNQDK-LNKSLKEEAMLQKQSCEELKS---DLNTKNE----LLKQKTIELTRACQKQYEL 352
Query: 1297 --EIPGHQVDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDE 1354
E+ +++D ++ P ++E G + ++ FA +D
Sbjct: 353 EQELAFYKIDAKFEPLNYYP-----SEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDS 407
Query: 1355 LDNISNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQE 1414
+ D + N M R + +++ K + T L + +E EK +Q+
Sbjct: 408 AQAVQIKKMEPDEQLRNDH-MNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQ 466
Query: 1415 IERVFHELILLQEE-KVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKNIIEDLN 1473
I R E L+E +++ +L KQ L+ L+NK
Sbjct: 467 ILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQ------------LVNK------- 507
Query: 1474 SVIRTQGQKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKY 1533
+ + L +E + +K + E ++ D+Q+ S D +
Sbjct: 508 -------------------LRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSK-- 546
Query: 1534 LNEPNYEALISIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQ-KDI-------- 1584
+P + + + + G EQ + +++K +++ ++L ++ K + + KD+
Sbjct: 547 --DPKHSHMKAQKSG-KEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQ 603
Query: 1585 --ANYALSCNLREELVAVSERKDICNAMGSKL--TCEKIVKERYENMMQQQKLTNISKQQ 1640
AN AL +L + + E ++ C K+ E+ E ++ Q+LT + +Q+
Sbjct: 604 IAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEK-ETLL--QRLTEV-EQE 659
Query: 1641 AEQISILQTEVERLR 1655
+Q+ I+ + E +R
Sbjct: 660 RDQLEIVAMDAENMR 674
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 66.6 bits (161), Expect = 2e-10
Identities = 195/969 (20%), Positives = 391/969 (40%), Gaps = 159/969 (16%)
Query: 730 KLLISLSSAMDKENHYLSTTPKVSVDL--GSDSEHTKQKASTDLSQDELVLTDVKKEIPW 787
++ +++ A ++ H T ++S L +DS+ + + +S + +L V + +
Sbjct: 563 RIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESV-- 620
Query: 788 IQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLE-NIAKLDQQEFGLDL 846
+ ++Q + K+ + K+R+ + GI+ L ++ + EN L+ N+A Q +
Sbjct: 621 -KDQNQHTMNKQ---YEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQE 676
Query: 847 EELERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVE 906
E LE+ + S+ E K ++ L K +++ ++S+A K L+ + +
Sbjct: 677 ELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIV---AYSSIAAKNAELEQ---ELMEK 730
Query: 907 NFPMKARTVEELKELERVL----QQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEE 962
N +++ E E++ + KKI E K E + ++ ++ + E+ D++
Sbjct: 731 NEKIRSLETNINTEHEKICLAFEKAKKIHLEQHK------EMEKQIERLEAQLEKKDQQF 784
Query: 963 EEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDIIYKVKTV 1022
+E++KT+ S L ++ +D L S+ E+ K ++ + +T+
Sbjct: 785 KEQEKTM--SMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETI 842
Query: 1023 FNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEE 1082
+ D+A EI + E++L L E + EK E+ L + EE
Sbjct: 843 KVRQLDSA-----LEICK--------EELVLHLNQLEG-------NKEKFEKQLKKKSEE 882
Query: 1083 ITAHKHIKPWHKAKEL-IVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIP 1141
+ + KEL I NH +Q+ S ++ IL+ +
Sbjct: 883 VYCLQ--------KELKIKNHS------LQETS----------------EQNVILQHTLQ 912
Query: 1142 QPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFD 1201
Q M + + + E EK+V +L +E K R+S +L+K++ + + D
Sbjct: 913 QQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEAD 972
Query: 1202 EHLKRLFE-----RRVKAEMVTNQEEL-KISNLAFSLLLD-EELSSREKFLNNYLTRKQH 1254
+++ E R+VK EM +EEL K+ L D E + L+ L + +
Sbjct: 973 LKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKT 1032
Query: 1255 EKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRP 1314
E + + AV+ +L+ + + L E + E G L +L + R
Sbjct: 1033 ELEKKTNAVK----ELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRD 1088
Query: 1315 RISKQKTHSETTSVVPFGELPGSGKLNKDAFAQL----MKAMDELDNISNMPEGLDPLVW 1370
+ K + E KD A+L M+ D+ + M + L W
Sbjct: 1089 VLQKAQLSLEEKYTT-----------IKDLTAELRECKMEIEDKKQELLEMDQALKERNW 1137
Query: 1371 ---------NHFCMT-RRAKVENEQKVKQKAADLLEMATFLQ---KRVEE-EEKVQQEIE 1416
H MT R + E EQK+ + L + L+ K++E +K+Q E
Sbjct: 1138 ELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKE 1197
Query: 1417 RVFH-ELILLQEEKVRFQLNLTIQILLKQGQVELENFQ------LVLEYSDAILINKNII 1469
++ E I+LQ E+ QL I+ +Q E+E+ + +Y +AI
Sbjct: 1198 QLREKEFIMLQNEQEISQLKKEIE-RTQQRMKEMESVMKEQEQYIATQYKEAI------- 1249
Query: 1470 EDLNSVIRTQGQKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRD 1529
DL +R ++ S E + + +Q + E +++ E ED+ Q S++
Sbjct: 1250 -DLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQ---------LSKE 1299
Query: 1530 RQKYLNEPNYEALIS-IQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQKDIANYA 1588
+ + N E S ++ +E + K VE+ K+ + S+Q++ A +
Sbjct: 1300 KDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAY-HMEMISHQENHAKWK 1358
Query: 1589 LSCNLREELVAVSERKDICNAMGSKLTCEKIVKERYENMMQQQKLTNISKQQAEQISILQ 1648
+S + ++ V + E++ K + E Q ++N+ +Q ++ +++
Sbjct: 1359 ISADSQKSSV--------------QQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIE 1404
Query: 1649 TEVERLRMK 1657
E L K
Sbjct: 1405 AANEALLTK 1413
Score = 47.0 bits (110), Expect = 2e-04
Identities = 203/1027 (19%), Positives = 407/1027 (39%), Gaps = 148/1027 (14%)
Query: 718 GHLASEILDYYQK------LLISLSSAMDKENHYLSTTPKVSVDLGSDSEHTKQKASTDL 771
G + S DYY K LL +++S H L T LG + ++D
Sbjct: 117 GEMESSSSDYYNKDNEEESLLANVASL----RHELKITEWSLQSLGEELSSVSPSENSDY 172
Query: 772 ----SQDELVLTDVKKEIPW------------IQQKSQEAIKKEVNLFSKKRKEIKQGIK 815
S+ E ++ DV+ P I S + KK + + Q IK
Sbjct: 173 APNPSRSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIK 232
Query: 816 SLSKTILNMMEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKS 875
SL + + + ++N A L Q L + + E +H E + AK V M A+
Sbjct: 233 SLREKLNKLRQQN------ACLVTQNHSL-MTKFESIHFELTQSRAK----VSMLESAQQ 281
Query: 876 YLAE--LIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELK-ELERVLQQKKIEA 932
A +++E+ N A K V+ K +++ E E+ LQ+ K
Sbjct: 282 QAASVPILEEQIINLEAEVSAQDK------VLREAENKLEQSQKMVIEKEQSLQESK--E 333
Query: 933 ECLKLRKEIVE-AQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGV-DT 990
EC+KL+ +++E + G + +QR+E EE +Y L + + + +
Sbjct: 334 ECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILER 393
Query: 991 SLLSSQLELHSREEKI----NQIILLKDIIYKVKTVFNNEFD----AAYKQKEFEIARVK 1042
+L + + E +E+ +++ +LK+ + ++K NN + A K E +A++
Sbjct: 394 NLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEV-MAQLT 452
Query: 1043 ERNVRIREIILDLELEEAVWQPEF----EDCE-------KPERTLVVQDEEITAHKHIKP 1091
E I ++ +LE ++ + + +F E+ E + ER + Q E ++ ++
Sbjct: 453 ESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRS 512
Query: 1092 WHK-AKELIVNHE----KEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIP---QP 1143
K +L + E K + Q +S + D G E K I + I +
Sbjct: 513 LEKIISQLPLKRELFGFKSYLSKYQMSSFSNKE--DRCIGCCEANKLVISELRIKLAIKE 570
Query: 1144 AFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYR-KSLEAELKKL-QNSIQESTQAFD 1201
A + K A T + Q + N+ ++ + SLE E KL + + ES + +
Sbjct: 571 AEIQKLHANLTANQLSQ------SLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQN 624
Query: 1202 EHLKRLFERRVKAEMVTNQEELK-------ISNLAFSLLLDEELSSREKFLNNYLTRKQH 1254
+H + + +VT EEL+ N + + S + L + +
Sbjct: 625 QHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASN 684
Query: 1255 EKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRP 1314
SE +K + L + K+ + ++A +S I ++ +L ++
Sbjct: 685 SSKLESEMTKKCSQLLTLEKQLEEKIVA------------YSSIAAKNAELEQELMEKNE 732
Query: 1315 RISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELD--------NISNMPEGLD 1366
+I +T+ T + K++ + ++ K ++ L+ + +
Sbjct: 733 KIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMS 792
Query: 1367 PLVWNHFCMTR------RAKVENEQKVKQKAADLLEMATFLQKRVEEEE-KVQQ---EIE 1416
L + C R E++ ++K++ E LQ +V EE KV+Q +E
Sbjct: 793 MLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALE 852
Query: 1417 RVFHELIL----LQEEKVRFQLNL---TIQILLKQGQVELENFQLVLEYSDAILINKNII 1469
EL+L L+ K +F+ L + ++ Q +++++N L E S+ +I ++ +
Sbjct: 853 ICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSL-QETSEQNVILQHTL 911
Query: 1470 EDLNSVIRTQGQKKVASMMESKDVHKRILQIEWE-HKKMEMEREDLNQKAWDIQMLFFSR 1528
+ +++ + + + K++ ++E E K+ E E L + +
Sbjct: 912 QQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEA 971
Query: 1529 D--RQKYLNEPNYEALISIQIGIMEQTIAVLDK--MH-KKNVENCKKLLKKLGKFSNQKD 1583
D RQK + + I++ ++ ++ ++K MH K++ EN L +L +Q
Sbjct: 972 DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQ-- 1029
Query: 1584 IANYALSCNLREELVAVSERKDICNAMGSKLTCEKIVKERYENMMQQQ--KLTNISKQQA 1641
L ++ AV E + + ++ ++LT +E E +Q +L + +Q
Sbjct: 1030 -----TKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQ 1084
Query: 1642 EQISILQ 1648
E +LQ
Sbjct: 1085 ELRDVLQ 1091
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 66.2 bits (160), Expect = 2e-10
Identities = 162/800 (20%), Positives = 332/800 (41%), Gaps = 84/800 (10%)
Query: 790 QKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEEL 849
++SQE I+ + + ++ E++ + LS + ++N+ E + K ++ +E L
Sbjct: 262 ERSQELIQLK-SQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRET----VEIL 316
Query: 850 ERLHDESQEEVAKMIKDVEMHNLAKSY----LAELIKEECWNSMAVKGRALKCFHIPCVV 905
E H E E A + ++ + L+ + +++ EE N G +
Sbjct: 317 ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIF 376
Query: 906 ENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEE 965
F + + L + VL +++ + LR+++ Q V L++Q+H++ +EE +
Sbjct: 377 SQFDYQDAD-KALTLVRSVLTRRRQAVQ--DLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433
Query: 966 DKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLEL--HSREEKINQIILLKDIIYKVKTV- 1022
+ ++ L + D + LS + EL +REE Q+ +L+ ++++ V
Sbjct: 434 RQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVN 493
Query: 1023 --FNNEFDAAYKQKEFEIAR----VKERNVRIREIILDLE------LEEAVWQPEFEDCE 1070
+ D+A QKE + V+ER R++E+++ LE L E + E +
Sbjct: 494 VELQLQGDSAQGQKEEQQEELHLAVRERE-RLQEMLMGLEAKQSESLSELITLREALESS 552
Query: 1071 KPERTLVVQDE-EITAHKHIKPWHKAKELIV------NHEKEHWLLIQDASTRLRALMDM 1123
E L+ Q++ E+TA +A++ I N K ++ A+ +L AL +
Sbjct: 553 HLEGELLRQEQTEVTA-----ALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEA 607
Query: 1124 MGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLE 1183
+ + +L++ + ++ +A E+ R + + ++ E + LE
Sbjct: 608 LALDKVGLNQQLLQLEEENQSVCSRMEA--AEQARNALQVDLAEAEKRREALWEKNTHLE 665
Query: 1184 AELKK-------LQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDE 1236
A+L+K LQ +++ + +E K+L E R + E T Q + L E
Sbjct: 666 AQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQ----LEQLHQEAKRQE 721
Query: 1237 ELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNL-----LAEDKVMDRSF 1291
E+ +R L R++ +AV + R+DL E L L E + +
Sbjct: 722 EVLARAVQEKEALVREKAALEVRLQAVERDRQDL---AEQLQGLSSAKELLESSLFEAQQ 778
Query: 1292 KKEFSEIPGHQVDILYKLFKRRPRISKQKTHSETTSV-VPFGELPGSGKLNKDAFA-QLM 1349
+ E+ Q+++ + + +K+ E + + + +DA A QL
Sbjct: 779 QNSVIEVTKGQLEVQIQTVTQ----AKEVIQGEVRCLKLELDTERSQAEQERDAAARQLA 834
Query: 1350 KAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQKVKQ----KAADLLEMATF-LQKR 1404
+A E + N R K E E+ Q KA + LE L+ R
Sbjct: 835 QAEQEGKTALEQQKAAHEKEVNQL----REKWEKERSWHQQELAKALESLEREKMELEMR 890
Query: 1405 VEEEE------KVQQEIERVFHELILLQEEKVRFQLNLTIQILLKQGQVELENFQLVLE- 1457
++E++ + Q+E ER E L Q + + +++ L Q Q EL + LE
Sbjct: 891 LKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLER 950
Query: 1458 YSDAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHK-RILQIEWEHKKMEMEREDLNQ 1516
+ + K ++ +++TQ Q+ + E+ H+ + ++ E + ++ DL +
Sbjct: 951 LRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQK 1010
Query: 1517 KAWDIQMLFFSRDRQKYLNE 1536
+ D++ ++D + L E
Sbjct: 1011 QVEDLKSQLVAQDDSQRLVE 1030
Score = 50.1 bits (118), Expect = 2e-05
Identities = 192/1061 (18%), Positives = 406/1061 (38%), Gaps = 161/1061 (15%)
Query: 686 IQSMRISMDGQNILVNGRDDGTLVYLKWKRFGGHLASEILDYYQKLLISLSSAMDKENHY 745
+Q+ + D L R D + LK + G L +++ Q+ L A +
Sbjct: 935 LQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQL----QEAQRELKEAARQHRDD 990
Query: 746 LSTTPKVSVDLGSDSEHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSK 805
L+ + S L D QK DL + +LV D + + ++Q+ QE ++ E +++
Sbjct: 991 LAALQEESSSLLQDKMDL-QKQVEDL-KSQLVAQDDSQRL--VEQEVQEKLR-ETQEYNR 1045
Query: 806 KRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIK 865
+KE+++ SL+ +++ + L+ + QQE ++++ E +E A+M
Sbjct: 1046 IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQM-- 1103
Query: 866 DVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVL 925
L + +KE+ + +A + + L+ + E ++L L
Sbjct: 1104 ---------ELLRQEVKEKEADFLAQEAQLLEELEASHITE------------QQLRASL 1142
Query: 926 QQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGS---- 981
++ +A L+LR E+Q ++ + + ++ + + YS L LGS
Sbjct: 1143 WAQEAKAAQLQLRLRSTESQ--LEALAAEQQPGNQAQAQAQLASLYSAL-QQALGSVCES 1199
Query: 982 ---LSTDFGVDTSLLSSQLELHSREEKINQIILLKDIIYK-VKTVFNNEFDAAYKQKEFE 1037
LS S+ + + + + LL + + V + + +K ++
Sbjct: 1200 RPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTR 1259
Query: 1038 IARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKE 1097
++++ ++ E + D E E++ E +D ++ + Q++E + K E
Sbjct: 1260 DV-LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQ----LSQNQEEKSKWEGKQNSLESE 1314
Query: 1098 LIVNHEKEHWLLIQDASTRLRAL----MDMMG--GVLEVKKEDI------LRMVIPQPAF 1145
L+ HE + +RLR M+ G +L+ KE++ L+ + +
Sbjct: 1315 LMELHE-----TMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARA 1369
Query: 1146 MAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLE------AELKKLQNSIQESTQA 1199
A + E+ R + K +E+ ER++ + E A+ K LQ ++ TQ
Sbjct: 1370 QASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQT 1429
Query: 1200 FDEHLKRLFERRVKAEMVTNQEELK---ISNLAFSL--------LLDEELSSREKFLN-- 1246
E + + R + + + Q E++ + L+ L L E++ EK +
Sbjct: 1430 LAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVL 1489
Query: 1247 NYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDIL 1306
+L E+ Q R+ +L+ +E N+L E ++++ K + E QV L
Sbjct: 1490 EHLPMAVQEREQKLTVQREQIRELEKDRETQRNVL-EHQLLELEKKDQMIESQRGQVQDL 1548
Query: 1307 YKLFKRRPRIS---KQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPE 1363
K ++ ++ H EL G + + A L ++E
Sbjct: 1549 KKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQS 1608
Query: 1364 GLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELI 1423
+ +H + R E +Q+VK + + E+ ++E + Q++ER EL+
Sbjct: 1609 SQIHDLESHSTVLARELQERDQEVKSQREQIEELQ-------RQKEHLTQDLERRDQELM 1661
Query: 1424 LLQE--------------------EKVRFQL-----NLTIQILLKQGQVE---------- 1448
L +E E+++ L LT Q L Q + E
Sbjct: 1662 LQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQR 1721
Query: 1449 --LENFQLVLEYSDAIL------------INKNIIEDLNSVIRTQGQKKVASMMESKDVH 1494
LE+ +L+L + + + + + L + R G+ + +++
Sbjct: 1722 GSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIV 1781
Query: 1495 KRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTI 1554
Q++ ++ E++ + L + + Q RD++ + + + + E+
Sbjct: 1782 VLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKAD 1841
Query: 1555 AVLDKMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAMGSKL 1614
A+ + + ++ L ++ G+ + K+ A L EEL R + L
Sbjct: 1842 ALQGALEQAHM----TLKERHGELQDHKEQAR-----RLEEELAVEGRRVQALEEVLGDL 1892
Query: 1615 TCEKIVKERYENMMQQQKLTNISKQQAEQISILQTEVERLR 1655
R E+ Q++ L + +Q AEQ + E L+
Sbjct: 1893 --------RAESREQEKALLALQQQCAEQAQEHEVETRALQ 1925
Score = 40.8 bits (94), Expect = 0.011
Identities = 173/954 (18%), Positives = 361/954 (37%), Gaps = 158/954 (16%)
Query: 789 QQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKL-ENIAKLDQQ------- 840
Q ++ K+ L + + + + L + + + D L + + KL+++
Sbjct: 1220 QNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAE 1279
Query: 841 --EFGLDLEELERLHDESQEEVAKM--------IKDVEMHNLAKSYLAELIKEECWNSMA 890
+ +L++L+R ++QEE +K + +E+H S + L + E A
Sbjct: 1280 KSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEA 1339
Query: 891 VKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKIEAECLK-LRKEIVEAQSGVK 949
R L + EN +++ L+ + + + +A L +++ A+S +K
Sbjct: 1340 QGEREL----LQAAKENL------TAQVEHLQAAVVEARAQASAAGILEEDLRTARSALK 1389
Query: 950 LIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQI 1009
L ++EE + E E + L +L + + T L+ REE++ +
Sbjct: 1390 L---KNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAE------REEEVETL 1440
Query: 1010 ILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDC 1069
+ KQ+E + A ++ ++ +++ +++L++ Q E E C
Sbjct: 1441 --------------RGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ-ELEKC 1485
Query: 1070 EK--PERTLVVQDEE---ITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMM 1124
+ VQ+ E + I+ K +E N EH LL + ++ +
Sbjct: 1486 RSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRN-VLEHQLLELEKKDQM--IESQR 1542
Query: 1125 GGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEA 1184
G V ++KK+ + + A+ EE + + +K +KEL +R+ R +L
Sbjct: 1543 GQVQDLKKQLVTLECL----------ALELEENHHKMECQQKLIKELEGQRETQRVALTH 1592
Query: 1185 ELKKLQNSIQE-STQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSREK 1243
L+ QE Q+ H + E+ +E+K EEL +++
Sbjct: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQI-----EELQRQKE 1647
Query: 1244 FLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQV 1303
L L R+ E E ++ + + +L ED + +E G ++
Sbjct: 1648 HLTQDLERRDQELMLQKERIQVLEDQ----RTRQTKILEEDLEQIKLSLRE----RGREL 1699
Query: 1304 DILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDEL-DNISNMP 1362
+L + R K + ++ S+ + + + + + + EL D +
Sbjct: 1700 TTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQL 1759
Query: 1363 EGLDPLVWNHFCMT--------------RRAKVENEQKVKQKAADLLEMATFLQKRVEEE 1408
+GL V + + A+ + E K + + L E L +R +E
Sbjct: 1760 QGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQEL 1819
Query: 1409 EKVQQEIERVFHELILLQEEKVRFQLNLT-IQILLKQGQVELENF---------QLVLEY 1458
E +QQE ++ + ++E+ Q L + LK+ EL++ +L +E
Sbjct: 1820 EALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVE- 1878
Query: 1459 SDAILINKNIIEDLNSVIRTQG------QKKVASMMESKDVHKRILQIEWEHKKMEMERE 1512
+ + ++ DL + R Q Q++ A + +V R LQ W + ++
Sbjct: 1879 GRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKER 1938
Query: 1513 DLNQKAWDIQMLFF------SRDRQKYLNEPNYEALISIQ------------IGIMEQTI 1554
D +A + +R R + L E +A ++Q +E +
Sbjct: 1939 DQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAST 1998
Query: 1555 AVLD------KMHKKNVENCKKLLKKLGKFSNQ-----KDIANYALSCNLR-EELVAVSE 1602
A L + H + +E ++ + G+ +Q +D+ + R EEL E
Sbjct: 1999 ATLQASLDACQAHSRQLEEALRIQE--GEIQDQDLRYQEDVQQLQQALAQRDEELRHQQE 2056
Query: 1603 RKDICNAMGSKLTCEKIVKERYENMMQQQKLTNISKQQAEQISILQTEVERLRM 1656
R+ + EK + +R + M Q+K +++ E+I L V L++
Sbjct: 2057 REQLL---------EKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQL 2101
Score = 38.1 bits (87), Expect = 0.072
Identities = 141/788 (17%), Positives = 314/788 (39%), Gaps = 126/788 (15%)
Query: 781 VKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILN----------MMEENDK 830
+K E +++ +A++++ L + K +++ + L++T+ ++E +K
Sbjct: 1390 LKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEK 1449
Query: 831 LENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMA 890
+ K + LDL++ + D QE++ ++ E+C + +
Sbjct: 1450 QREMQKAALELLSLDLKKRNQEVDLQQEQIQEL-------------------EKCRSVLE 1490
Query: 891 VKGRALKCFHIPCVVENFPMKARTV-EELKELE--RVLQQKKIEAECLKLRK--EIVEAQ 945
H+P V+ K E+++ELE R Q+ +E + L+L K +++E+Q
Sbjct: 1491 ---------HLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQ 1541
Query: 946 SG-VKLIKQRHEEDD----EEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELH 1000
G V+ +K++ + E EE K L L G T +L L+L
Sbjct: 1542 RGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQ---RVALTHLTLDLE 1598
Query: 1001 SREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEA 1060
R +++ + TV E ++++ E+ +E ++EE
Sbjct: 1599 ERSQELQAQSSQIHDLESHSTVLAREL----QERDQEVKSQRE------------QIEEL 1642
Query: 1061 VWQPEF--EDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLR 1118
Q E +D E+ ++ L++Q E I +++ + ++++ +++
Sbjct: 1643 QRQKEHLTQDLERRDQELMLQKERI-------------QVLEDQRTRQTKILEEDLEQIK 1689
Query: 1119 ALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKV---KELNEER 1175
+ G L +++ +++ + +K E + +D EK+V +E E
Sbjct: 1690 LSLRERGRELTTQRQ-LMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHEL 1748
Query: 1176 DKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSL-LL 1234
+ + LE +L+ L + E++ + + + + + + Q ELK +L L
Sbjct: 1749 QELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEA 1808
Query: 1235 DEELSSREKFLNNYLTRKQHEKSQ------TSEAVRKSREDLDVCKEHYDNLLAEDKVMD 1288
L+ R++ L +Q + Q ++A++ + E + + L + K
Sbjct: 1809 QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQA 1868
Query: 1289 RSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLN----KDA 1344
R ++E + + G +V L ++ S+++ + E ++ +D+
Sbjct: 1869 RRLEEELA-VEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDS 1927
Query: 1345 FAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKA--------ADLLE 1396
+ Q + E D + H RA+ E Q+ KA LLE
Sbjct: 1928 WLQAQAVLKERDQELEALRA-ESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLE 1986
Query: 1397 MATFLQKRVEEEEKVQQEIE------RVFHELILLQE-----EKVRFQLNL-TIQILLKQ 1444
A + +Q ++ R E + +QE + +R+Q ++ +Q L Q
Sbjct: 1987 QAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQ 2046
Query: 1445 GQVELENFQ---LVLEYSDAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQIE 1501
EL + Q +LE S A + +N+I++ ++ + + ++++ + +S R LQ+
Sbjct: 2047 RDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQS----VRELQLT 2102
Query: 1502 WEHKKMEM 1509
K+ E+
Sbjct: 2103 LAQKEQEI 2110
Score = 33.5 bits (75), Expect = 1.8
Identities = 106/545 (19%), Positives = 212/545 (38%), Gaps = 89/545 (16%)
Query: 755 DLGSDSEHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGI 814
+L E Q + + L+L+ ++EI +QQ+ QEA +++ E+K+
Sbjct: 1750 ELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEA---------REQGELKE-- 1798
Query: 815 KSLSKTILNMMEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAK 874
+++ + ++E + +A+ DQ+ L+ + E+ + QEE K D L +
Sbjct: 1799 ----QSLQSQLDEAQRA--LAQRDQE---LEALQQEQQQAQGQEERVKEKADALQGALEQ 1849
Query: 875 SYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKIEAEC 934
+++ +KE K +A + + E ++ R V+ L+E+
Sbjct: 1850 AHMT--LKERHGELQDHKEQARR------LEEELAVEGRRVQALEEV------------L 1889
Query: 935 LKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLS 994
LR E E + + ++Q+ E +E E E + ++ S L + D ++
Sbjct: 1890 GDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAV-LKERDQELEALRAE 1948
Query: 995 SQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILD 1054
SQ H E + L++ + K + +Q E++R E + + LD
Sbjct: 1949 SQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQA--ELSRSLEASTATLQASLD 2006
Query: 1055 L------ELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKA-----KELIVNHE 1103
+LEEA+ E E +QD+++ + ++ +A +EL E
Sbjct: 2007 ACQAHSRQLEEALRIQEGE----------IQDQDLRYQEDVQQLQQALAQRDEELRHQQE 2056
Query: 1104 KEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQFKD 1163
+E L A ++ + + ++E+ +R + E +
Sbjct: 2057 REQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQS-----------VRELQLTLAQ 2105
Query: 1164 YEKKVKELNEERDKYRKSLEAELKKLQNSIQE----STQAFDEHLKRLFERRVKAEMVTN 1219
E+++ EL E + R +LEA + S E + + L+R ER A T
Sbjct: 2106 KEQEILELRETQQ--RNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTE 2163
Query: 1220 QEEL----KISNLAFSLLLDE----ELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLD 1271
E+ K +LA SL + L FL + + E+ + + + +R L+
Sbjct: 2164 AREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALE 2223
Query: 1272 VCKEH 1276
+ H
Sbjct: 2224 KERLH 2228
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 66.2 bits (160), Expect = 2e-10
Identities = 188/941 (19%), Positives = 382/941 (40%), Gaps = 128/941 (13%)
Query: 733 ISLSSAMDKENHYLSTTPKVSV-DLGSDSEHTKQKASTDLSQDELVLTDVKKEIPWIQQK 791
I ++ A KE L T V +L D H ++K + L +D L+ K E+ +
Sbjct: 2002 IQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQS-LEKDSQALSLTKCEL----EN 2056
Query: 792 SQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEELER 851
+ KE L K+ + ++ + LN+ K A +++ EF L L +
Sbjct: 2057 QIAQLNKEKELLVKESESLQARLSESDYEKLNV----SKALEAALVEKGEFALRLSSTQE 2112
Query: 852 LHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMK 911
+ + + K+ +E + ++AE +KE + ++K + VEN +
Sbjct: 2113 EVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDK----------VENLERE 2162
Query: 912 ARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVK-----LIKQRHEEDDEEEEEED 966
+ EE +EL +L + +AE L+ +I E +K L+ R E+++ ++ ++
Sbjct: 2163 LQMSEENQELV-ILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQE 2221
Query: 967 KTVKYSNLPNYLLGSLSTDFGVDTSLLSS--QLELHSREEKINQIILLKDIIYKVKTVFN 1024
K + S L LL S SLL Q E+ +EE + +L++ + ++
Sbjct: 2222 KQGQLSELDK-LLSSFK-------SLLEEKEQAEIQIKEESKTAVEMLQNQLKEL----- 2268
Query: 1025 NEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAV--WQPEFEDCEKPERTLVVQDEE 1082
NE AA + EI + E+++ I + +L ++ + E EK + ++ Q +E
Sbjct: 2269 NEAVAALCGDQ-EIMKATEQSLD-PPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKE 2326
Query: 1083 ITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRAL-MDMMGGVLEVKKEDILRMVIP 1141
H + K + N E+E L I + AL + G +E K I M
Sbjct: 2327 SEHHADL-----LKGRVENLERE--LEIARTNQEHAALEAENSKGEVETLKAKIEGMT-- 2377
Query: 1142 QPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFD 1201
Q + D V E+ E EL +E+++ + LE +N +QE Q
Sbjct: 2378 QSLRGLELDVVTIRSEK------ENLTNELQKEQERISE-LEIINSSFENILQEKEQE-- 2428
Query: 1202 EHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEE--LSSREKFLNNYLTRKQHEKSQT 1259
K + + M Q +LK N + L +++ ++E+ L++ + + EK+Q
Sbjct: 2429 ---KVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQL 2485
Query: 1260 SEAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQ 1319
+ + +++ + V + + L+ E + + +K+ EI K
Sbjct: 2486 LQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISR----------------LKN 2529
Query: 1320 KTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRA 1379
+ + V ++ G +L K+ +L EL+ + + + + + + + +
Sbjct: 2530 QIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSS 2589
Query: 1380 KVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTIQ 1439
E +++ D + + K +E ++Q+E+ + + LQEE + L +
Sbjct: 2590 YKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGE 2649
Query: 1440 ILLKQGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQ 1499
+ L +++ QL + L N + + L+ + + Q +K+ E + R+ +
Sbjct: 2650 LQLLLEEIKSSKDQL----KELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHE 2705
Query: 1500 IEWEH--------KKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIME 1551
E +H K+ E+E + +K + S+ + L + + E L + ++
Sbjct: 2706 AEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNN----SLK 2761
Query: 1552 QTIAVLDKMHKKNVEN-----------------CKKLLKKLGKFSNQKDIANYALSCNLR 1594
T +L+++ K ++N K L+K + +K+I LS
Sbjct: 2762 ATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELS---- 2817
Query: 1595 EELVAVSERKDICNAMGSK---LTCEKIVKERYENMMQQQK 1632
+L A E++ M +K LT E +KE E + ++ K
Sbjct: 2818 -QLQAAQEKQKTGTVMDTKVDELTTE--IKELKETLEEKTK 2855
Score = 53.5 bits (127), Expect = 2e-06
Identities = 183/909 (20%), Positives = 373/909 (41%), Gaps = 157/909 (17%)
Query: 819 KTILNMMEENDKLENIAKLDQQEFGLDLE-----ELERLHDESQEEVAKMIKDVEMHNLA 873
+++LN M+E D +KL QE L + ELE++ E ++E + + + +E +
Sbjct: 1798 ESLLNEMKELD-----SKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCD 1852
Query: 874 KSYLAELIK-EECWNS---MAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQK- 928
L + ++ E NS M + + N K R ++ EL R+ +K
Sbjct: 1853 HQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKA 1912
Query: 929 KIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEE-----EDKTVKYSNLPNYLLGSLS 983
IE E L L ++ Q+ + E+D+E +++ E++ ++ N L G L
Sbjct: 1913 SIEHEALYLEADLEVVQTEKLCL----EKDNENKQKVIVCLEEELSVVTSERNQLRGELD 1968
Query: 984 TDFGVDTSL--LSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARV 1041
T T+L LS +++ ++E + +Q L I + A V
Sbjct: 1969 TMSKKTTALDQLSEKMKEKTQELESHQSECLHCI-------------------QVAEAEV 2009
Query: 1042 KERNVRIREI---ILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKEL 1098
KE+ ++ + + +L ++ Q + + EK + L + E+ I +K KEL
Sbjct: 2010 KEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCEL--ENQIAQLNKEKEL 2067
Query: 1099 IVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMA-----KPDAVW 1153
+V + + ++ + + L K E LR+ Q + V
Sbjct: 2068 LVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVR 2127
Query: 1154 TEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVK 1213
E + K+ +K+KE E D SL+ +++ L+ +Q S + ++ L L K
Sbjct: 2128 IEADEKKQLHIAEKLKEREREND----SLKDKVENLERELQMSEE--NQELVILDAENSK 2181
Query: 1214 AEMVTNQEELKISNLAFSLLLDE-ELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDV 1272
AE+ T + + I +A SL + E +L + N + Q ++ Q SE LD
Sbjct: 2182 AEVETLKTQ--IEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSE--------LDK 2231
Query: 1273 CKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTHSETTSVVPFG 1332
+ +LL E + + K+E V++L K E V
Sbjct: 2232 LLSSFKSLLEEKEQAEIQIKEESKT----AVEMLQNQLK------------ELNEAV--A 2273
Query: 1333 ELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQK----VK 1388
L G ++ K L ++E + N E L RA++E ++K V
Sbjct: 2274 ALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKL------------RARLEADEKKQLCVL 2321
Query: 1389 QKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQL-------------- 1434
Q+ + A L+ RVE E+ + EI R E L+ E + ++
Sbjct: 2322 QQLKESEHHADLLKGRVENLER-ELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSL 2380
Query: 1435 -NLTIQILLKQGQVELENFQLVLE---YSDAILIN---KNIIEDLNSVIRTQGQKKVASM 1487
L + ++ + + E +L E S+ +IN +NI+++ + Q ++K ++
Sbjct: 2381 RGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQE-KVQMKEKSSTA 2439
Query: 1488 MES-----KDVHKRILQIEWEHKKMEMEREDLNQKAWDIQM----LFFSRDRQKYLNEPN 1538
ME K++++R+ + + + + + ++L+ + +++ L D K N
Sbjct: 2440 MEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAK----NN 2495
Query: 1539 YEALISIQIGIMEQTIAVLDKMHKKN---------VENCKKLLKKLGKFSNQKDIANYAL 1589
Y L S G++++ K+ KK+ +++ ++L+ KL + + +
Sbjct: 2496 YIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWK-EQ 2554
Query: 1590 SCNLREELVAVSERKDICNAMGSKL-TCEKIVKERYENMMQQQKLTNISK----QQAEQI 1644
+ LR V + ++ + + + L ++++ Y+N+ + +LT + K ++ ++
Sbjct: 2555 NLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKM 2614
Query: 1645 SILQTEVER 1653
+ +TE++R
Sbjct: 2615 TAKETELQR 2623
Score = 50.8 bits (120), Expect = 1e-05
Identities = 171/875 (19%), Positives = 348/875 (39%), Gaps = 135/875 (15%)
Query: 753 SVDLGSDSEHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQ 812
S DL EH ++ + LS+ E + + +++K E +K+E LFS + E ++
Sbjct: 570 SQDLLKKREHHIEQLNDKLSKTEKESKALLSALE-LKKKEYEELKEEKTLFSCWKSENEK 628
Query: 813 GIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNL 872
+ + N+ + + LE K QQ + E R + +E ++ I++ +HN+
Sbjct: 629 LLTQMESEKENLQSKINHLETCLK-TQQIKSHEYNERVRTLEMDRENLSVEIRN--LHNV 685
Query: 873 AKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKIEA 932
S E VE + +++ E QK+IE
Sbjct: 686 LDSKSVE-------------------------VETQKLAYMELQQKAEFSDQKHQKEIEN 720
Query: 933 ECLK---LRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLL---GSLSTDF 986
CLK L ++ + + ++L+ +E D++ +D +Y +L + L SL T+
Sbjct: 721 MCLKTSQLTGQVEDLEHKLQLLS--NEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNE 778
Query: 987 GVDTSLLS--SQLELH-----------SREEKINQIILLKDIIYKVKTVFNNEFDAAYKQ 1033
SLL+ Q +H S + ++ L D K + N D+
Sbjct: 779 DHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSL--- 835
Query: 1034 KEFEIARVKERNVRIREIILDL-----ELEEAVWQPEFED----CEKPERTLVVQDEEIT 1084
EF + K+ N +++ +L E+EE + + E E +R +Q E+ +
Sbjct: 836 -EFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQ-EDTS 893
Query: 1085 AHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPA 1144
AH+++ + + N EKE LL T + ++ K +L + +
Sbjct: 894 AHQNVVA--ETLSALENKEKELQLLNDKVETEQAEIQELK------KSNHLLEDSLKELQ 945
Query: 1145 FMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHL 1204
+++ ++ +E +++++EL +E K + A L + + ++ + +++F ++
Sbjct: 946 LLSETLSLEKKEMSSIISLNKREIEELTQENGTL-KEINASLNQEKMNLIQKSESFANYI 1004
Query: 1205 KRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVR 1264
ER +++Q K L +E ++ E Y + EK+ E +
Sbjct: 1005 D---EREKSISELSDQ--YKQEKLILLQRCEETGNAYEDLSQKY--KAAQEKNSKLECL- 1056
Query: 1265 KSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTHSE 1324
L+ C +N E + + +F KE HQ + L KL R E
Sbjct: 1057 -----LNECTSLCENRKNELEQLKEAFAKE------HQ-EFLTKLAFAEERNQNLMLELE 1104
Query: 1325 TTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENE 1384
T E+ D +N + GL + MT + E +
Sbjct: 1105 TVQQALRSEM-----------------TDNQNNSKSEAGGLKQEI-----MTLK---EEQ 1139
Query: 1385 QKVKQKAADLLEMATFLQKRVEEEEKVQQ-EIERVFHELILLQEEKVRFQLNLTIQILLK 1443
K++++ DLL+ L K ++ + + Q E E + + + + E R Q N Q+ L+
Sbjct: 1140 NKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNS--VKERESERNQCNFKPQMDLE 1197
Query: 1444 QGQVELENFQLVLEYSDAILINKNI--------IEDLNSVIRT-QGQKKVASM--MESKD 1492
++ L+++ L +A+L NK + E L ++T +G + +++ M+S++
Sbjct: 1198 VKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQE 1257
Query: 1493 VH-KRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIME 1551
+ + +I+ E K + E + + + + LNE E + I
Sbjct: 1258 ISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNE--LEKICEILQAEKY 1315
Query: 1552 QTIAVLDKMHKKNVENCKKLLKKLGKFSNQKDIAN 1586
+ + L+ + + +K+ +++GK N+ I N
Sbjct: 1316 ELVTELNDSRSECITATRKMAEEVGKLLNEVKILN 1350
Score = 45.1 bits (105), Expect = 6e-04
Identities = 92/486 (18%), Positives = 193/486 (39%), Gaps = 52/486 (10%)
Query: 764 KQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSK------KRKEIKQGIKSL 817
K+K+ST + + L ++ + + + + KE NL S+ ++ ++ QG+
Sbjct: 2433 KEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEA 2492
Query: 818 SKTILNMMEENDKLENIAKLDQQEFGLDLEELERLHDE--SQEEVAKMIKDVE-MHNLAK 874
+ + + L + +Q+ EE+ RL ++ QE++ + VE H L K
Sbjct: 2493 KNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWK 2552
Query: 875 SYLAELIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKIEAEC 934
EL ++ K + +E + +E EL ++ + +E
Sbjct: 2553 EQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVE--- 2609
Query: 935 LKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLS 994
K+ K +E + + E + K + L L G + G LL
Sbjct: 2610 --------------KVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLE 2655
Query: 995 SQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILD 1054
E+ S ++++ ++ L + K D +K + + +V+E I E L
Sbjct: 2656 ---EIKSSKDQLKELTLENSELKK-------SLDCMHKDQVEKEGKVREE---IAEYQLR 2702
Query: 1055 LELEEAVWQPEFEDCEKP-ERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQDA 1113
L E Q D K E + E++T+ + K + ++ KE A
Sbjct: 2703 LHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKA 2762
Query: 1114 STRL-----RALMDMMGGVLEVKKEDI-----LRMVIPQPAFMAKPDAVWTEEERKQFKD 1163
+T++ + MD + V ++KKE+ ++++I + + + ++E Q +
Sbjct: 2763 TTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEI-LQKELSQLQA 2821
Query: 1164 YEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEEL 1223
++K K D L E+K+L+ +++E T+ DE+L + + E + +E+
Sbjct: 2822 AQEKQKT-GTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEM 2880
Query: 1224 KISNLA 1229
+ +A
Sbjct: 2881 LETQVA 2886
Score = 42.4 bits (98), Expect = 0.004
Identities = 115/564 (20%), Positives = 216/564 (38%), Gaps = 71/564 (12%)
Query: 794 EAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEELERLH 853
E K EV K + + Q ++ L ++ + E + L N + +Q+ + ELE ++
Sbjct: 2360 ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQER----ISELEIIN 2415
Query: 854 DES----QEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENFP 909
QE+ + ++ E + A L +KE + + AL C +
Sbjct: 2416 SSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKE-----LNERVAALHNDQEACKAKEQN 2470
Query: 910 MKARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTV 969
+ ++ E ELE+ + ++ + + + QS V + Q E+ ++ E++D+ +
Sbjct: 2471 LSSQV--ECLELEKAQLLQGLD----EAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEI 2524
Query: 970 KYSNLPNY------LLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVF 1023
S L N L+ LS G LEL + ++ Q I +
Sbjct: 2525 --SRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDT 2582
Query: 1024 NNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEI 1083
++YK E E+ K + E + + +E Q E E ++T +Q EE+
Sbjct: 2583 LEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMH--EMAQKTAELQ-EEL 2639
Query: 1084 TAHKHIKPWHKAKELI-----VNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRM 1138
+ K+ A EL + K+ + ++ L+ +D M +V+KE +R
Sbjct: 2640 SGEKN----RLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKD-QVEKEGKVRE 2694
Query: 1139 VIPQPAFMAKPDAVWTEEERKQF-------KDYEKKVKELNE-----ERDKYRKSLEAEL 1186
I + E E+K K YE +++ E E + LE +L
Sbjct: 2695 EIAEYQLRLH------EAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDL 2748
Query: 1187 KK-----LQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSR 1241
K L NS++ +TQ +E K + + + E + + ++L
Sbjct: 2749 LKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEE 2808
Query: 1242 EKFLNNYLTRKQ--HEKSQTSEAVRKSREDLDV-CKEHYDNLLAEDKVMDRSFKKEFSEI 1298
++ L L++ Q EK +T + ++L KE + L + K D K S +
Sbjct: 2809 KEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLL 2868
Query: 1299 PGHQVDILYKLFKRRPRISKQKTH 1322
H+ KL K + + Q H
Sbjct: 2869 ISHE-----KLEKAKEMLETQVAH 2887
Score = 41.6 bits (96), Expect = 0.006
Identities = 73/376 (19%), Positives = 158/376 (42%), Gaps = 31/376 (8%)
Query: 1155 EEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHL---KRLFER- 1210
++ ++ E+K+K+L E+ R++ E+ L+ I+E + F E L +R F+
Sbjct: 351 DQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTL 410
Query: 1211 -----RVKAEMVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRK 1265
++KA + ++ K + LD +L+S ++ L N L + + + +A +
Sbjct: 411 DQECIQMKARLTQELQQAKNMHNVLQAELD-KLTSVKQQLENNLEEFKQKLCRAEQAFQA 469
Query: 1266 SREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKR-RPRISKQKTHSE 1324
S+ KE+ E+ + + K SE +V L K + +++ + +E
Sbjct: 470 SQ-----IKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAE 524
Query: 1325 TTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENE 1384
E+ + L + +++ +N + E L V + + + ++
Sbjct: 525 --------EMKAKNTSQETMLRDLQEKINQQENSLTL-EKLKLAVAD----LEKQRDCSQ 571
Query: 1385 QKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQL-NLTIQILLK 1443
+K++ + ++ L K +E + + +E E L+EEK F + LL
Sbjct: 572 DLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLT 631
Query: 1444 QGQVELENFQLVLEYSDAILINKNI-IEDLNSVIRTQGQKKVASMMESKDVHKRILQIEW 1502
Q + E EN Q + + + L + I + N +RT + +E +++H +
Sbjct: 632 QMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSV 691
Query: 1503 EHKKMEMEREDLNQKA 1518
E + ++ +L QKA
Sbjct: 692 EVETQKLAYMELQQKA 707
Score = 41.2 bits (95), Expect = 0.008
Identities = 104/528 (19%), Positives = 213/528 (40%), Gaps = 82/528 (15%)
Query: 1164 YEKKVKELNEERDKYRKSLEAELKKLQ--NSIQESTQAFDEHLKRLFERRVKAEMVTNQE 1221
YE ++ N+E ++ RK LEAE+K LQ + Q QA H + + + + + + Q+
Sbjct: 164 YEDLKEKYNKEVEE-RKRLEAEVKALQAKKASQTLPQATMNH-RDIARHQASSSVFSWQQ 221
Query: 1222 ELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDN-- 1279
E S+L+ + + R F +Y + +Q E + + ++ + D + +DN
Sbjct: 222 EKTPSHLSSN---SQRTPIRRDFSASYFSGEQ-EVTPSRSTLQIGKRDAN--SSFFDNSS 275
Query: 1280 ---LLAEDKVMDRSFKKEFSE----IPGHQVDI---LYKLFKRRPRISKQKTHSETTSVV 1329
LL + K ++ + + +E + GH+ ++ + K + + ++ K K
Sbjct: 276 SPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKV-------- 327
Query: 1330 PFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQKVKQ 1389
EL K+ +L++ + D S L EQK+K+
Sbjct: 328 ---ELIEKEKVLNKCRDELVRTTAQYDQASTKYTAL------------------EQKLKK 366
Query: 1390 KAADL--------LEMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTIQIL 1441
DL + QK E+E++ Q+E+ R L +E ++ + LT ++
Sbjct: 367 LTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQ 426
Query: 1442 LKQG-----QVELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKR 1496
+ Q EL+ V + + N +E+ + Q AS ++ ++ +
Sbjct: 427 QAKNMHNVLQAELDKLTSVKQQLE------NNLEEFKQKLCRAEQAFQASQIKENELRRS 480
Query: 1497 ILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAV 1556
+ +++ E+ ++ E QKA ++ L K + ++ Q +
Sbjct: 481 MEEMKKENNLLKSHSE---QKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETML 537
Query: 1557 LDKMHKKNVENCKKLLKKL----GKFSNQKDIANYALSCNLREELVAVSERKDICNAMGS 1612
D K N + L+KL Q+D + L RE + K S
Sbjct: 538 RDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLL--KKREHHIEQLNDKLSKTEKES 595
Query: 1613 K--LTCEKIVKERYENMMQQQKLTNISKQQAEQ-ISILQTEVERLRMK 1657
K L+ ++ K+ YE + +++ L + K + E+ ++ +++E E L+ K
Sbjct: 596 KALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSK 643
Score = 41.2 bits (95), Expect = 0.008
Identities = 108/531 (20%), Positives = 219/531 (41%), Gaps = 66/531 (12%)
Query: 1166 KKVKELNEERDKYRKSLEAELKKLQN-------SIQESTQAFDEHLKRLFERRVKAEMVT 1218
K V+EL + YR+SLE +K+++ IQE Q + L ++ + ++
Sbjct: 1547 KGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQEL--DCLRKQYLS 1604
Query: 1219 NQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYD 1278
E+ + + +L ++ +L++ +K + + S E R + LD+
Sbjct: 1605 ENEQWQQKLTSVTLEMESKLAAEKK--------QTEQLSLELEVARLQLQGLDLSSRSLL 1656
Query: 1279 NLLAEDKVMDRSFKKEFSE---------IPGHQV-DILYKLFKRRPRISKQKTHSETTSV 1328
+ ED + R+ + S+ P H V I K ++ + +K +ET +V
Sbjct: 1657 GIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKI-TETGAV 1715
Query: 1329 VPFGELPG--SGKLNKDAFAQLMKAMDELDNISNMP-EGLDPLVWNHFCMTRRAKVENEQ 1385
P GE G S N + + K + IS + G + LV F + +
Sbjct: 1716 KPTGECSGEQSPDTNYEPPGE-DKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQL 1774
Query: 1386 KVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTIQILLKQG 1445
+VK+ + + L + ++ R + E + E++ + +L LQE ++ ++ I++ G
Sbjct: 1775 RVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKL-HLQEVQLMTKIEACIELEKIVG 1833
Query: 1446 QVELENFQL--VLEY----SDAILINKNIIEDLNSVIRTQGQK--------KVASMMESK 1491
+++ EN L LEY +L E LNS + K VA + +S
Sbjct: 1834 ELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDS- 1892
Query: 1492 DVHKRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIME 1551
+R L +E E ++ E+ + +A ++ +K E + E + + + E
Sbjct: 1893 -WKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEE 1951
Query: 1552 QTIAV----------LDKMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVS 1601
+ V LD M KK + K K + + L C ++ V
Sbjct: 1952 ELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHC-IQVAEAEVK 2010
Query: 1602 ERKDICNAMGSKLTCEKIVKERYENMMQQQKLTNISKQQAEQISILQTEVE 1652
E+ ++ + S ++ +++K++ Q+KL ++ K ++ +S+ + E+E
Sbjct: 2011 EKTELLQTLSSDVS--ELLKDKTH---LQEKLQSLEK-DSQALSLTKCELE 2055
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 65.9 bits (159), Expect = 3e-10
Identities = 166/860 (19%), Positives = 343/860 (39%), Gaps = 123/860 (14%)
Query: 756 LGSDSEHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIK 815
L ++E K K ++ V+ K ++ Q+A+++ FSK
Sbjct: 552 LSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFA 611
Query: 816 SLSKTILNM-MEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAK 874
L I M ++ ++EN+ E +E+E L + ++ K+IK+ E N +
Sbjct: 612 ELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL----RAKLMKVIKEKE--NSLE 665
Query: 875 SYLAELIKEECWNSMAVKGRALKCFHIPCVVENFP-MKARTVEELKELERVLQQKKIEAE 933
+ ++L K E + + ++ K V+ ++A+ E+ K ++ Q K E
Sbjct: 666 AIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEE 725
Query: 934 CL----KLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVD 989
L LRK E +S +K ++Q + E +K +K+ + S ++ +
Sbjct: 726 KLLDLDALRKASSEGKSEMKKLRQ-------QLEAAEKQIKHLEIEKNAESSKASS--IT 776
Query: 990 TSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEF-----DAAYKQKEFE--IARVK 1042
L +L+L + +E ++++ +K+ + K + +F +A Q+ + + ++
Sbjct: 777 RELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLH 836
Query: 1043 ERNVRIREIILDLE-LEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVN 1101
++ + + DLE L E + E + EK ER +E++ KAKE + N
Sbjct: 837 QKEEQFNMLSSDLEKLRENLADMEAKFREKDER-----EEQLI---------KAKEKLEN 882
Query: 1102 HEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQF 1161
E + D S++L + D L +K+ D+
Sbjct: 883 DIAEIMKMSGDNSSQLTKMNDE----LRLKERDV-------------------------- 912
Query: 1162 KDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERR---VKAEMVT 1218
++ + K+ + NE +KS+E K + S QE+ + +E K L ER+ ++ +M T
Sbjct: 913 EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKEL-ERKLSDLEKKMET 971
Query: 1219 NQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYD 1278
+ + + + E + E+ L N + + + + L +E
Sbjct: 972 SHNQCQELKARYERATSETKTKHEEILQN-----------LQKTLLDTEDKLKGAREENS 1020
Query: 1279 NLLAE-DKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTHSETTSVVPFGELPGS 1337
LL E +++ ++ K + ++ + I+ ++ K + ++ T+ EL
Sbjct: 1021 GLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1080
Query: 1338 GKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEM 1397
+ N +L K+ + L V N R ++E +KQ AA +
Sbjct: 1081 KENNLKNVEELNKSKELL------------TVENQKMEEFRKEIET---LKQAAAQKSQQ 1125
Query: 1398 ATFLQKRVEEEEKVQQEIERVFHELILLQE-EKVRFQLNLTI-------QILLKQGQVEL 1449
+ LQ EE K+ +E+ R E+ Q+ E+ R LN + +K E
Sbjct: 1126 LSALQ---EENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK 1182
Query: 1450 ENFQLVLEYSDAILINKNI-IEDL-NSVIRTQGQKKVASMMESKDVHKRILQIEWEHKKM 1507
+ Q + + A+L K+ +E L N V +G+ A K +H + +E + K+
Sbjct: 1183 ASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASA-----KSLHSVVQTLESDKVKL 1237
Query: 1508 EMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDKMHKKNVEN 1567
E++ ++L + + + S E QI + I L + + ++++
Sbjct: 1238 ELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKN-QDLKM 1296
Query: 1568 CKKLLKKLGKFSNQKDIANY 1587
+++ + N D+ NY
Sbjct: 1297 KVEMMSEAALNGNGDDLNNY 1316
Score = 36.6 bits (83), Expect = 0.21
Identities = 105/544 (19%), Positives = 217/544 (39%), Gaps = 90/544 (16%)
Query: 1158 RKQFKDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMV 1217
++ K+ ++ +++L ERD R + + QE A D H + + E K + +
Sbjct: 354 QEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413
Query: 1218 -----------------TNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTS 1260
+E+ K+ +L F ++EE ++ ++ K
Sbjct: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFR--VEEESITKGDLEVATVSEKSRIMELEK 471
Query: 1261 EAVRKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEI--------PGHQVDI--LYKLF 1310
+ + +E ++ + N A D M S +E S + HQ +I L + F
Sbjct: 472 DLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHF 531
Query: 1311 KRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDE-LDNISNMPEGLDPLV 1369
R ++TH + + + K N+ ++L A E D I+ L+ +
Sbjct: 532 GAR-----EETHQKEIKAL-YTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAI 585
Query: 1370 WNHFCMTRRAKVENEQKVKQKAADLLEMATFLQK-RVEEEEKV-----QQEIERVFHELI 1423
+H KV + + + A+ E+ T ++K R++ + ++ QQ+ ER H
Sbjct: 586 ASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAH--- 642
Query: 1424 LLQEEKVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQKK 1483
K L + ++K+ + LE + L+ ++ +++++E +++ + Q
Sbjct: 643 ----AKEMEALRAKLMKVIKEKENSLEAIRSKLDKAE----DQHLVEMEDTLNKLQ---- 690
Query: 1484 VASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALI 1543
E K +LQ + + ++ KA + ++L R+ + +
Sbjct: 691 ---EAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKL 747
Query: 1544 SIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQKDIANYALS-CNLREELVAVSE 1602
Q+ E+ I L+ +KN E+ K S +++ L NL+E L VS+
Sbjct: 748 RQQLEAAEKQIKHLE--IEKNAESSK-------ASSITRELQGRELKLTNLQENLSEVSQ 798
Query: 1603 RKDICNAMGSKLTCEK---IVKERYENMMQQ--------QKLTNISKQQAEQISILQTEV 1651
K+ T EK I+KE++ ++ Q+ N Q+ EQ ++L +++
Sbjct: 799 VKE---------TLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDL 849
Query: 1652 ERLR 1655
E+LR
Sbjct: 850 EKLR 853
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 65.9 bits (159), Expect = 3e-10
Identities = 166/860 (19%), Positives = 343/860 (39%), Gaps = 123/860 (14%)
Query: 756 LGSDSEHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIK 815
L ++E K K ++ V+ K ++ Q+A+++ FSK
Sbjct: 587 LSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFA 646
Query: 816 SLSKTILNM-MEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAK 874
L I M ++ ++EN+ E +E+E L + ++ K+IK+ E N +
Sbjct: 647 ELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL----RAKLMKVIKEKE--NSLE 700
Query: 875 SYLAELIKEECWNSMAVKGRALKCFHIPCVVENFP-MKARTVEELKELERVLQQKKIEAE 933
+ ++L K E + + ++ K V+ ++A+ E+ K ++ Q K E
Sbjct: 701 AIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEE 760
Query: 934 CL----KLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVD 989
L LRK E +S +K ++Q + E +K +K+ + S ++ +
Sbjct: 761 KLLDLDALRKASSEGKSEMKKLRQ-------QLEAAEKQIKHLEIEKNAESSKASS--IT 811
Query: 990 TSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEF-----DAAYKQKEFE--IARVK 1042
L +L+L + +E ++++ +K+ + K + +F +A Q+ + + ++
Sbjct: 812 RELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLH 871
Query: 1043 ERNVRIREIILDLE-LEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVN 1101
++ + + DLE L E + E + EK ER +E++ KAKE + N
Sbjct: 872 QKEEQFNMLSSDLEKLRENLADMEAKFREKDER-----EEQLI---------KAKEKLEN 917
Query: 1102 HEKEHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQF 1161
E + D S++L + D L +K+ D+
Sbjct: 918 DIAEIMKMSGDNSSQLTKMNDE----LRLKERDV-------------------------- 947
Query: 1162 KDYEKKVKELNEERDKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERR---VKAEMVT 1218
++ + K+ + NE +KS+E K + S QE+ + +E K L ER+ ++ +M T
Sbjct: 948 EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKEL-ERKLSDLEKKMET 1006
Query: 1219 NQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYD 1278
+ + + + E + E+ L N + + + + L +E
Sbjct: 1007 SHNQCQELKARYERATSETKTKHEEILQN-----------LQKTLLDTEDKLKGAREENS 1055
Query: 1279 NLLAE-DKVMDRSFKKEFSEIPGHQVDILYKLFKRRPRISKQKTHSETTSVVPFGELPGS 1337
LL E +++ ++ K + ++ + I+ ++ K + ++ T+ EL
Sbjct: 1056 GLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1115
Query: 1338 GKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEM 1397
+ N +L K+ + L V N R ++E +KQ AA +
Sbjct: 1116 KENNLKNVEELNKSKELL------------TVENQKMEEFRKEIET---LKQAAAQKSQQ 1160
Query: 1398 ATFLQKRVEEEEKVQQEIERVFHELILLQE-EKVRFQLNLTI-------QILLKQGQVEL 1449
+ LQ EE K+ +E+ R E+ Q+ E+ R LN + +K E
Sbjct: 1161 LSALQ---EENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK 1217
Query: 1450 ENFQLVLEYSDAILINKNI-IEDL-NSVIRTQGQKKVASMMESKDVHKRILQIEWEHKKM 1507
+ Q + + A+L K+ +E L N V +G+ A K +H + +E + K+
Sbjct: 1218 ASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASA-----KSLHSVVQTLESDKVKL 1272
Query: 1508 EMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDKMHKKNVEN 1567
E++ ++L + + + S E QI + I L + + ++++
Sbjct: 1273 ELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKN-QDLKM 1331
Query: 1568 CKKLLKKLGKFSNQKDIANY 1587
+++ + N D+ NY
Sbjct: 1332 KVEMMSEAALNGNGDDLNNY 1351
Score = 32.7 bits (73), Expect = 3.0
Identities = 113/577 (19%), Positives = 229/577 (39%), Gaps = 121/577 (20%)
Query: 1158 RKQFKDYEKKVKELNEERDKYRK----------------------------SLEAELKKL 1189
++ K+ ++ +++L ERD R LEA++ +L
Sbjct: 354 QEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413
Query: 1190 QNSIQESTQAFDEHLKRLFERRVKAEMV-----------------TNQEELKISNLAFSL 1232
+ ++ + + E L +L E + K E + T E +I L SL
Sbjct: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSL 473
Query: 1233 LLDEELSSR-EKFLNNYLTRKQHEKSQTSEAVR----KSREDLDVCKEHYDNLLAEDKVM 1287
L ++ + + ++ L + EKS+ E + + +E ++ + N A D M
Sbjct: 474 LFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDM 533
Query: 1288 DRSFKKEFSEI--------PGHQVDI--LYKLFKRRPRISKQKTHSETTSVVPFGELPGS 1337
S +E S + HQ +I L + F R ++TH + + +
Sbjct: 534 SLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAR-----EETHQKEIKAL-YTATEKL 587
Query: 1338 GKLNKDAFAQLMKAMDE-LDNISNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLLE 1396
K N+ ++L A E D I+ L+ + +H KV + + + A+ E
Sbjct: 588 SKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAE 647
Query: 1397 MATFLQK-RVEEEEKV-----QQEIERVFHELILLQEEKVRFQLNLTIQILLKQGQVELE 1450
+ T ++K R++ + ++ QQ+ ER H K L + ++K+ + LE
Sbjct: 648 LKTQIEKMRLDYQHEIENLQNQQDSERAAH-------AKEMEALRAKLMKVIKEKENSLE 700
Query: 1451 NFQLVLEYSDAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQIEWEHKKMEME 1510
+ L+ ++ +++++E +++ + Q E K +LQ + + ++
Sbjct: 701 AIRSKLDKAE----DQHLVEMEDTLNKLQ-------EAEIKVKELEVLQAKCNEQTKVID 749
Query: 1511 REDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDKMHKKNVENCKK 1570
KA + ++L R+ + + Q+ E+ I L+ +KN E+ K
Sbjct: 750 NFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLE--IEKNAESSK- 806
Query: 1571 LLKKLGKFSNQKDIANYALS-CNLREELVAVSERKDICNAMGSKLTCEK---IVKERYEN 1626
S +++ L NL+E L VS+ K+ T EK I+KE++
Sbjct: 807 ------ASSITRELQGRELKLTNLQENLSEVSQVKE---------TLEKELQILKEKFAE 851
Query: 1627 MMQQ--------QKLTNISKQQAEQISILQTEVERLR 1655
++ Q+ N Q+ EQ ++L +++E+LR
Sbjct: 852 ASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLR 888
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 65.5 bits (158), Expect = 4e-10
Identities = 178/931 (19%), Positives = 378/931 (40%), Gaps = 103/931 (11%)
Query: 789 QQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEE 848
Q + +EA ++++ L K E K IK L IL M ++N+KL KL ++ + +
Sbjct: 958 QLEEEEAARQKLQL-EKVTAEAK--IKKLEDEILVMDDQNNKLSKERKLLEER----ISD 1010
Query: 849 LERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKC------FHIP 902
L E +E+ + K H S L +K+E + ++ K FH
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH-- 1068
Query: 903 CVVENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRH------- 955
E + ELK ++ ++++++A +L EI + + +K I++
Sbjct: 1069 ---EQIADLQAQIAELK-MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1124
Query: 956 EEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDI 1015
E+ D E +K K L +L T+ ++Q EL ++ E+ ++ +LK
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ--EVTVLKKA 1182
Query: 1016 IYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERT 1075
+ + + ++ + + E+ + + +L+ + + E D R
Sbjct: 1183 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242
Query: 1076 LVVQDEEITAHKHIKPWHKAKELI--VNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKE 1133
L +E+ HK K + +EL + + + D +L+ ++ + G+L +
Sbjct: 1243 LGQAKQEVE-HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1301
Query: 1134 DILRMV--IPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQN 1191
+++ + + + +EE +Q + K+++L EER+ + L+ E++ QN
Sbjct: 1302 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1361
Query: 1192 SIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSR-EKFLNNYLT 1250
+ H+ L + + + K+ + A ++ EE R +K + N LT
Sbjct: 1362 --------LERHISTL-------NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN-LT 1405
Query: 1251 RKQHEKSQTSEAVRKSR----EDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDIL 1306
++ EK+ + + K++ ++LD DN +++ +++F ++ + +I
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK-QRKFDQLLAEEKNIS 1464
Query: 1307 YKLFKRRPRISKQKTHSET----------TSVVPFGELPGSGKLNKDAFAQLMKAMDEL- 1355
K R R + ET ++ EL + K+ K L+ + D++
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524
Query: 1356 DNISNMPEGLDPLVWNHFCM-TRRAKVENEQKVKQKAADLLEM---------ATFLQKRV 1405
N+ + + L M T+ ++E+E + + A LE+ LQ R
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584
Query: 1406 EEEEKVQQEIERVFHEL-ILLQEEKVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILI 1464
E+ E+ +++++R HE L++E+ + L + L+ +LE L+ AI
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE-----LQADSAIKG 1639
Query: 1465 NKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQIEWEHKKMEMERE-DLNQKAWDIQM 1523
+ I+ L ++ Q + + +++ I E++K E DL Q D+
Sbjct: 1640 REEAIKQLRK-LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 1524 LFFSRDRQKYLNEPNYEALISIQIG---------IMEQTIAVLDKMHKKNVENCKKLLKK 1574
+R + E E L S G +E IA L++ ++ N + + +
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1758
Query: 1575 LGKFSNQ-----KDIANYALSCNLREELVAVSERKDICNAMGSKL-TCEKIVKERYENMM 1628
+ K + Q ++A + E ER++ + SKL E VK ++++ +
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESARQQLERQN--KELRSKLHEMEGAVKSKFKSTI 1816
Query: 1629 Q--QQKLTNISKQQAEQISILQTEVERLRMK 1657
+ K+ + +Q ++ Q + L+ K
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847
Score = 63.2 bits (152), Expect = 2e-09
Identities = 147/785 (18%), Positives = 330/785 (42%), Gaps = 119/785 (15%)
Query: 911 KARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVK 970
K + + ++ E +Q K+ E + K R++ +A++ +K ++Q+H + EE+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQ--KAENELKELEQKHSQLTEEK-------- 889
Query: 971 YSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAA 1030
N L L + + ++ L ++++++ +I+ +E +A
Sbjct: 890 -----NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL--------------HEMEAR 930
Query: 1031 YKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIK 1090
+++E +++ ++ + +LDLE + E+ E + L Q E++TA IK
Sbjct: 931 LEEEEDRGQQLQAERKKMAQQMLDLE-------EQLEEEEAARQKL--QLEKVTAEAKIK 981
Query: 1091 PWHKAKELIVNHE------KEHWLLIQDAS----------------TRLRALMDMMGGVL 1128
E++V + KE LL + S T+L+ + M L
Sbjct: 982 KLE--DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1039
Query: 1129 EV--KKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAEL 1186
EV KKE+ R + + + DA + +Q D + ++ EL + K + L+A L
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDA---SDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1096
Query: 1187 KKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLL------LDEELSS 1240
+L + I + A LK++ R ++ + QE+L A + L EEL +
Sbjct: 1097 ARLDDEIAQKNNA----LKKI--RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 1241 REKFLNNYLTRKQHEKSQTSEAVRKSRE-DLDVCKEHYDNLLAEDKVMDRSFKKEFSEIP 1299
+ L + L + + T + +R RE ++ V K+ D + + +++ ++
Sbjct: 1151 LKTELEDTL-----DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1205
Query: 1300 GHQVDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNI- 1358
+ L + + + + K K E + GEL G+ ++ + K ++ +
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 1359 SNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERV 1418
S +G RA+ E KV + ++ + L + + K+ +++ +
Sbjct: 1266 SKCSDG------------ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 1419 FHELILLQE---EKVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKNIIEDLNSV 1475
+L QE E+ R +LN++ K Q+E E L + + + +N+ ++++
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVS----TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 1476 -IRTQGQKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYL 1534
I+ KK + +D + +E K+ + E E+L Q+ + + ++ K
Sbjct: 1370 NIQLSDSKK-----KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424
Query: 1535 NEPNYEALISIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLR 1594
+ + L+ + + Q ++ L+K +K + + K+++++D A
Sbjct: 1425 LQQELDDLV-VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---E 1480
Query: 1595 EELVAVSERKDICNAMGSKLTCE---KIVKERYENMMQQQKLTNISKQQAEQIS-ILQTE 1650
+E A+S + + A+ +K E K++K E+++ + + + E+ L+T+
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 1651 VERLR 1655
+E ++
Sbjct: 1541 MEEMK 1545
Score = 60.1 bits (144), Expect = 2e-08
Identities = 145/716 (20%), Positives = 292/716 (40%), Gaps = 112/716 (15%)
Query: 760 SEHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSK 819
++ T +K + DL+ + VL K+E+ ++K + + +E++ +
Sbjct: 1225 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV-----------QELQSKCSDGER 1273
Query: 820 TILNMMEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSYLAE 879
+ ++ KL+N ++E + + +E++ + K+ KDV + E
Sbjct: 1274 ARAELNDKVHKLQN-----------EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1322
Query: 880 LIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEEL---KELERVLQQKKIEAECLK 936
L++EE + V + + E ++ + EE+ + LER + I+ K
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEE-----ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377
Query: 937 LRKE----IVEA-QSGVKLIKQRHEEDDEEEEEE----DKTVKYSNLPNYLLGSLSTDFG 987
+ + VEA + G K ++ E ++ EE+ DK K N L L D
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437
Query: 988 VDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKE---FEIARVKER 1044
L+S+ L ++ K +Q++ + I + +A ++KE +AR E
Sbjct: 1438 NQRQLVSN---LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 1045 NVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEK 1104
+ +E +LE + + E ED LV +++ K++ K+K +
Sbjct: 1495 ALEAKE---ELERTNKMLKAEMED-------LVSSKDDV--GKNVHELEKSKRALETQ-- 1540
Query: 1105 EHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDA--VWTEEERKQFK 1162
+++ T+L L D + + K + M + F A EE+R+Q +
Sbjct: 1541 -----MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 1163 ----DYEKKVKELNEER---DKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAE 1215
+YE ++++ ++R +K LE +LK L+ + + +E +K+L R+++A+
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL--RKLQAQ 1653
Query: 1216 MVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTS------------EAV 1263
M Q E L++ +SR++ + T K++EK S A
Sbjct: 1654 MKDFQRE-----------LEDARASRDEI---FATAKENEKKAKSLEADLMQLQEDLAAA 1699
Query: 1264 RKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRR-------PRI 1316
++R+ D+ KE LA + + E + + +L + + R+
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759
Query: 1317 SKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMT 1376
K +E S E + K N+ A QL + EL + + EG +
Sbjct: 1760 RKATQQAEQLSNELATERSTAQK-NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 1377 RRAKV-ENEQKVKQKAADLLEMATFLQKRVEEEEKV--QQEIERVFHELILLQEEK 1429
AK+ + E++V+Q+A + L+++ ++ +++ Q E ER E Q EK
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874
Score = 56.2 bits (134), Expect = 3e-07
Identities = 175/868 (20%), Positives = 346/868 (39%), Gaps = 156/868 (17%)
Query: 824 MMEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKE 883
M + D+L+ K QQ+ +L+ELE+ H + EE K+ L E ++
Sbjct: 854 MQAKEDELQK-TKERQQKAENELKELEQKHSQLTEE--------------KNLLQEQLQA 898
Query: 884 ECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVE 943
E E M+ R + +ELE +L + + E + R + ++
Sbjct: 899 E----------------TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 942
Query: 944 AQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSRE 1003
A+ K+ +Q + +++ EEEE K QLE + E
Sbjct: 943 AER-KKMAQQMLDLEEQLEEEEAARQKL------------------------QLEKVTAE 977
Query: 1004 EKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQ 1063
KI + L+D I V +++ + K+++ R+ + + E E E+A
Sbjct: 978 AKIKK---LEDEI----LVMDDQNNKLSKERKLLEERISDLTTNLAE-----EEEKAKNL 1025
Query: 1064 PEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDM 1123
+ K + ++ + E+ K K +EL EK L DAS + D+
Sbjct: 1026 TKL----KNKHESMISELEVRLKKEEK---SRQEL----EKLKRKLEGDASDFHEQIADL 1074
Query: 1124 MGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEER-KQFKDYEKKVKELNEERDKYRKSL 1182
+ E+K + + Q A D + + K+ ++ E + +L E+ D R +
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER-AA 1133
Query: 1183 EAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSRE 1242
+ +K + + E +A L+ + + + + E +++ L LDEE S E
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL--KKALDEETRSHE 1191
Query: 1243 KFLNNYLTRKQH-----EKSQTSEAVRKSREDLDVCKEHYD----NLLAEDKVMDRS--- 1290
+ R++H E ++ E ++++ +LD K+ + +L E +V+ ++
Sbjct: 1192 AQVQE--MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249
Query: 1291 --FKKEFSEIPGHQVDILYKLFKRRPRISKQKTH---SETTSVVPFGELPGSGKLNKDAF 1345
KK+ E ++ +R K H +E SV +G LN +A
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV--------TGMLN-EAE 1300
Query: 1346 AQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRV 1405
+ +K ++ ++S+ + L+ + + + V K L E LQ ++
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELL--------QEETRQKLNVSTKLRQLEEERNSLQDQL 1352
Query: 1406 EEEEKVQQEIERVFHEL-ILLQEEKVRFQ-LNLTIQIL---LKQGQVELENFQLVLEYS- 1459
+EE + +Q +ER L I L + K + Q T++ L K+ Q E+EN E
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 1460 ---DAILINKNIIEDL--NSVIRTQGQKKVASMMESKDVHKRILQIEWEHKKM------E 1508
D + KN ++ + V+ Q+++ S +E K ++ Q+ E K + E
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK--QRKFDQLLAEEKNISSKYADE 1470
Query: 1509 MEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDKMHKKNVENC 1568
+R + + + + L +R ++ L ++ + +KM K +E+
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALE--------------AKEELERTNKMLKAEMEDL 1516
Query: 1569 KKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAM-GSKLTCE---KIVKERY 1624
+GK ++ + + AL + E + E +D A +KL E + +K ++
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576
Query: 1625 ENMMQQQKLTNISKQQAEQISILQTEVE 1652
E +Q + N K++ Q + + E E
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETE 1604
Score = 42.4 bits (98), Expect = 0.004
Identities = 88/462 (19%), Positives = 177/462 (38%), Gaps = 79/462 (17%)
Query: 1128 LEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQ-----FKDYEKKVKELNEERDKYRKSL 1182
L K + +L++ + AK D + +ER+Q K+ E+K +L EE++ ++ L
Sbjct: 837 LFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 896
Query: 1183 E------AELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLL--- 1233
+ AE ++++ + Q +E L + R + E Q + + +A +L
Sbjct: 897 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956
Query: 1234 --LDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSF 1291
L+EE ++R+K Q EK ++K +++ V + + L E K+++
Sbjct: 957 EQLEEEEAARQKL--------QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1008
Query: 1292 K-------------KEFSEIPGHQVDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSG 1338
K +++ ++ +L R + K + E G+
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068
Query: 1339 KLNKDAFAQL-------------------------------MKAMDELD-NISNMPEGLD 1366
+ D AQ+ +K + EL+ +IS++ E LD
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 1367 P--LVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELIL 1424
N +R E + +K + D L+ Q+ + E+ +++ E
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 1425 LQEEKVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKNIIE----DLNSVIRTQG 1480
E +V+ Q +++ +LE F+ D NK +E DL +R G
Sbjct: 1189 SHEAQVQEMRQKHAQ-AVEELTEQLEQFKRAKANLDK---NKQTLEKENADLAGELRVLG 1244
Query: 1481 QKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQ 1522
Q K + K + ++ +++ + E R +LN K +Q
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Score = 41.6 bits (96), Expect = 0.006
Identities = 64/283 (22%), Positives = 116/283 (40%), Gaps = 43/283 (15%)
Query: 1380 KVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTIQ 1439
KV+ +V ++ ++ LQK E ++K + E++ + + L EEK
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK---------N 890
Query: 1440 ILLKQGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQ 1499
+L +Q Q E E + E + K +E++ + A + E +D R Q
Sbjct: 891 LLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL-------HEMEARLEEEED---RGQQ 940
Query: 1500 IEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDK 1559
++ E KKM + DL ++ + + RQK E + +I +E I V+D
Sbjct: 941 LQAERKKMAQQMLDLEEQLEEEEAA-----RQKLQLE---KVTAEAKIKKLEDEILVMDD 992
Query: 1560 MHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAMGSKLT---- 1615
+ K + K L +++ L+ NL EE + N S ++
Sbjct: 993 QNNKLSKERKLLEERISD-----------LTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041
Query: 1616 -CEKIVKERYENMMQQQKLTNISKQQAEQISILQTEVERLRMK 1657
+K K R E ++KL + EQI+ LQ ++ L+M+
Sbjct: 1042 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084
Score = 40.8 bits (94), Expect = 0.011
Identities = 103/535 (19%), Positives = 208/535 (38%), Gaps = 65/535 (12%)
Query: 714 KRFGGHLASEILDYYQKLLISLSSAMDK----ENHYLSTTPKVSVDLGSDSEHTKQKAST 769
KRF + + Y +K ++A DK +N + VDL + +
Sbjct: 1395 KRFQKEIENLTQQYEEK-----AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Query: 770 DLSQDELVLTDVKKEIPWIQQKSQ---EAIKKEVNLFSKKRK-----EIKQGIKSLSKTI 821
D+L+ + + ++ + EA +KE S R E K+ ++ +K +
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 822 LNMMEE-----NDKLENIAKLDQQEFGLDLE------ELERLHDESQE-EVAKMIKDVEM 869
ME+ +D +N+ +L++ + L+ + +LE L DE Q E AK+ +V M
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1569
Query: 870 HNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENF-PMKARTVEELKELERVLQQK 928
L + +L + N + + +E+ +A K+LE L+
Sbjct: 1570 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1629
Query: 929 KIEAE-CLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFG 987
+++A+ +K R+E ++ +L K + + D + E ED + +
Sbjct: 1630 ELQADSAIKGREEAIK-----QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684
Query: 988 VDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVR 1047
++ L+ Q +L + E Q L K+ + + + +A +K AR+ +
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 1048 IREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHW 1107
+ E ++E + + E+ L E TA K+ A++ + KE
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELAT--ERSTAQKN----ESARQQLERQNKELR 1798
Query: 1108 LLIQDASTRLRALMDMMGGVLEVKKEDILRMV-------------IPQPAFMAKPDAVWT 1154
+ + +++ LE K + V + Q K +
Sbjct: 1799 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV 1858
Query: 1155 EEERKQFKDYEK-------KVKELN---EERDKYRKSLEAELKKLQNSIQESTQA 1199
E+ERK + Y++ +VK+L EE ++ + + A +KLQ + E+T++
Sbjct: 1859 EDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 65.5 bits (158), Expect = 4e-10
Identities = 178/931 (19%), Positives = 378/931 (40%), Gaps = 103/931 (11%)
Query: 789 QQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEE 848
Q + +EA ++++ L K E K IK L IL M ++N+KL KL ++ + +
Sbjct: 965 QLEEEEAARQKLQL-EKVTAEAK--IKKLEDEILVMDDQNNKLSKERKLLEER----ISD 1017
Query: 849 LERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKC------FHIP 902
L E +E+ + K H S L +K+E + ++ K FH
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH-- 1075
Query: 903 CVVENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRH------- 955
E + ELK ++ ++++++A +L EI + + +K I++
Sbjct: 1076 ---EQIADLQAQIAELK-MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1131
Query: 956 EEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDI 1015
E+ D E +K K L +L T+ ++Q EL ++ E+ ++ +LK
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ--EVTVLKKA 1189
Query: 1016 IYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERT 1075
+ + + ++ + + E+ + + +L+ + + E D R
Sbjct: 1190 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249
Query: 1076 LVVQDEEITAHKHIKPWHKAKELI--VNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKE 1133
L +E+ HK K + +EL + + + D +L+ ++ + G+L +
Sbjct: 1250 LGQAKQEVE-HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1308
Query: 1134 DILRMV--IPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQN 1191
+++ + + + +EE +Q + K+++L EER+ + L+ E++ QN
Sbjct: 1309 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1368
Query: 1192 SIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSR-EKFLNNYLT 1250
+ H+ L + + + K+ + A ++ EE R +K + N LT
Sbjct: 1369 --------LERHISTL-------NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN-LT 1412
Query: 1251 RKQHEKSQTSEAVRKSR----EDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDIL 1306
++ EK+ + + K++ ++LD DN +++ +++F ++ + +I
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK-QRKFDQLLAEEKNIS 1471
Query: 1307 YKLFKRRPRISKQKTHSET----------TSVVPFGELPGSGKLNKDAFAQLMKAMDEL- 1355
K R R + ET ++ EL + K+ K L+ + D++
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531
Query: 1356 DNISNMPEGLDPLVWNHFCM-TRRAKVENEQKVKQKAADLLEM---------ATFLQKRV 1405
N+ + + L M T+ ++E+E + + A LE+ LQ R
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591
Query: 1406 EEEEKVQQEIERVFHEL-ILLQEEKVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILI 1464
E+ E+ +++++R HE L++E+ + L + L+ +LE L+ AI
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE-----LQADSAIKG 1646
Query: 1465 NKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQIEWEHKKMEMERE-DLNQKAWDIQM 1523
+ I+ L ++ Q + + +++ I E++K E DL Q D+
Sbjct: 1647 REEAIKQLRK-LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 1524 LFFSRDRQKYLNEPNYEALISIQIG---------IMEQTIAVLDKMHKKNVENCKKLLKK 1574
+R + E E L S G +E IA L++ ++ N + + +
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1765
Query: 1575 LGKFSNQ-----KDIANYALSCNLREELVAVSERKDICNAMGSKL-TCEKIVKERYENMM 1628
+ K + Q ++A + E ER++ + SKL E VK ++++ +
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLERQN--KELRSKLHEMEGAVKSKFKSTI 1823
Query: 1629 Q--QQKLTNISKQQAEQISILQTEVERLRMK 1657
+ K+ + +Q ++ Q + L+ K
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854
Score = 63.2 bits (152), Expect = 2e-09
Identities = 147/785 (18%), Positives = 330/785 (42%), Gaps = 119/785 (15%)
Query: 911 KARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVK 970
K + + ++ E +Q K+ E + K R++ +A++ +K ++Q+H + EE+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQ--KAENELKELEQKHSQLTEEK-------- 896
Query: 971 YSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAA 1030
N L L + + ++ L ++++++ +I+ +E +A
Sbjct: 897 -----NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL--------------HEMEAR 937
Query: 1031 YKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIK 1090
+++E +++ ++ + +LDLE + E+ E + L Q E++TA IK
Sbjct: 938 LEEEEDRGQQLQAERKKMAQQMLDLE-------EQLEEEEAARQKL--QLEKVTAEAKIK 988
Query: 1091 PWHKAKELIVNHE------KEHWLLIQDAS----------------TRLRALMDMMGGVL 1128
E++V + KE LL + S T+L+ + M L
Sbjct: 989 KLE--DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1046
Query: 1129 EV--KKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAEL 1186
EV KKE+ R + + + DA + +Q D + ++ EL + K + L+A L
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDA---SDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1103
Query: 1187 KKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLL------LDEELSS 1240
+L + I + A LK++ R ++ + QE+L A + L EEL +
Sbjct: 1104 ARLDDEIAQKNNA----LKKI--RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 1241 REKFLNNYLTRKQHEKSQTSEAVRKSRE-DLDVCKEHYDNLLAEDKVMDRSFKKEFSEIP 1299
+ L + L + + T + +R RE ++ V K+ D + + +++ ++
Sbjct: 1158 LKTELEDTL-----DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1212
Query: 1300 GHQVDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNI- 1358
+ L + + + + K K E + GEL G+ ++ + K ++ +
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 1359 SNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERV 1418
S +G RA+ E KV + ++ + L + + K+ +++ +
Sbjct: 1273 SKCSDG------------ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 1419 FHELILLQE---EKVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKNIIEDLNSV 1475
+L QE E+ R +LN++ K Q+E E L + + + +N+ ++++
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVS----TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 1476 -IRTQGQKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYL 1534
I+ KK + +D + +E K+ + E E+L Q+ + + ++ K
Sbjct: 1377 NIQLSDSKK-----KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431
Query: 1535 NEPNYEALISIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLR 1594
+ + L+ + + Q ++ L+K +K + + K+++++D A
Sbjct: 1432 LQQELDDLV-VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---E 1487
Query: 1595 EELVAVSERKDICNAMGSKLTCE---KIVKERYENMMQQQKLTNISKQQAEQIS-ILQTE 1650
+E A+S + + A+ +K E K++K E+++ + + + E+ L+T+
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 1651 VERLR 1655
+E ++
Sbjct: 1548 MEEMK 1552
Score = 60.1 bits (144), Expect = 2e-08
Identities = 145/716 (20%), Positives = 292/716 (40%), Gaps = 112/716 (15%)
Query: 760 SEHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSK 819
++ T +K + DL+ + VL K+E+ ++K + + +E++ +
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV-----------QELQSKCSDGER 1280
Query: 820 TILNMMEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSYLAE 879
+ ++ KL+N ++E + + +E++ + K+ KDV + E
Sbjct: 1281 ARAELNDKVHKLQN-----------EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1329
Query: 880 LIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEEL---KELERVLQQKKIEAECLK 936
L++EE + V + + E ++ + EE+ + LER + I+ K
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEE-----ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 937 LRKE----IVEA-QSGVKLIKQRHEEDDEEEEEE----DKTVKYSNLPNYLLGSLSTDFG 987
+ + VEA + G K ++ E ++ EE+ DK K N L L D
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444
Query: 988 VDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKE---FEIARVKER 1044
L+S+ L ++ K +Q++ + I + +A ++KE +AR E
Sbjct: 1445 NQRQLVSN---LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 1045 NVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEK 1104
+ +E +LE + + E ED LV +++ K++ K+K +
Sbjct: 1502 ALEAKE---ELERTNKMLKAEMED-------LVSSKDDV--GKNVHELEKSKRALETQ-- 1547
Query: 1105 EHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDA--VWTEEERKQFK 1162
+++ T+L L D + + K + M + F A EE+R+Q +
Sbjct: 1548 -----MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 1163 ----DYEKKVKELNEER---DKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAE 1215
+YE ++++ ++R +K LE +LK L+ + + +E +K+L R+++A+
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL--RKLQAQ 1660
Query: 1216 MVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTS------------EAV 1263
M Q E L++ +SR++ + T K++EK S A
Sbjct: 1661 MKDFQRE-----------LEDARASRDEI---FATAKENEKKAKSLEADLMQLQEDLAAA 1706
Query: 1264 RKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRR-------PRI 1316
++R+ D+ KE LA + + E + + +L + + R+
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766
Query: 1317 SKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMT 1376
K +E S E + K N+ A QL + EL + + EG +
Sbjct: 1767 RKATQQAEQLSNELATERSTAQK-NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 1377 RRAKV-ENEQKVKQKAADLLEMATFLQKRVEEEEKV--QQEIERVFHELILLQEEK 1429
AK+ + E++V+Q+A + L+++ ++ +++ Q E ER E Q EK
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881
Score = 56.2 bits (134), Expect = 3e-07
Identities = 175/868 (20%), Positives = 346/868 (39%), Gaps = 156/868 (17%)
Query: 824 MMEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKE 883
M + D+L+ K QQ+ +L+ELE+ H + EE K+ L E ++
Sbjct: 861 MQAKEDELQK-TKERQQKAENELKELEQKHSQLTEE--------------KNLLQEQLQA 905
Query: 884 ECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVE 943
E E M+ R + +ELE +L + + E + R + ++
Sbjct: 906 E----------------TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 949
Query: 944 AQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSRE 1003
A+ K+ +Q + +++ EEEE K QLE + E
Sbjct: 950 AER-KKMAQQMLDLEEQLEEEEAARQKL------------------------QLEKVTAE 984
Query: 1004 EKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQ 1063
KI + L+D I V +++ + K+++ R+ + + E E E+A
Sbjct: 985 AKIKK---LEDEI----LVMDDQNNKLSKERKLLEERISDLTTNLAE-----EEEKAKNL 1032
Query: 1064 PEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDM 1123
+ K + ++ + E+ K K +EL EK L DAS + D+
Sbjct: 1033 TKL----KNKHESMISELEVRLKKEEK---SRQEL----EKLKRKLEGDASDFHEQIADL 1081
Query: 1124 MGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEER-KQFKDYEKKVKELNEERDKYRKSL 1182
+ E+K + + Q A D + + K+ ++ E + +L E+ D R +
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER-AA 1140
Query: 1183 EAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSRE 1242
+ +K + + E +A L+ + + + + E +++ L LDEE S E
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL--KKALDEETRSHE 1198
Query: 1243 KFLNNYLTRKQH-----EKSQTSEAVRKSREDLDVCKEHYD----NLLAEDKVMDRS--- 1290
+ R++H E ++ E ++++ +LD K+ + +L E +V+ ++
Sbjct: 1199 AQVQE--MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256
Query: 1291 --FKKEFSEIPGHQVDILYKLFKRRPRISKQKTH---SETTSVVPFGELPGSGKLNKDAF 1345
KK+ E ++ +R K H +E SV +G LN +A
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV--------TGMLN-EAE 1307
Query: 1346 AQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRV 1405
+ +K ++ ++S+ + L+ + + + V K L E LQ ++
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELL--------QEETRQKLNVSTKLRQLEEERNSLQDQL 1359
Query: 1406 EEEEKVQQEIERVFHEL-ILLQEEKVRFQ-LNLTIQIL---LKQGQVELENFQLVLEYS- 1459
+EE + +Q +ER L I L + K + Q T++ L K+ Q E+EN E
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 1460 ---DAILINKNIIEDL--NSVIRTQGQKKVASMMESKDVHKRILQIEWEHKKM------E 1508
D + KN ++ + V+ Q+++ S +E K ++ Q+ E K + E
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK--QRKFDQLLAEEKNISSKYADE 1477
Query: 1509 MEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDKMHKKNVENC 1568
+R + + + + L +R ++ L ++ + +KM K +E+
Sbjct: 1478 RDRAEAEAREKETKALSLARALEEALE--------------AKEELERTNKMLKAEMEDL 1523
Query: 1569 KKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAM-GSKLTCE---KIVKERY 1624
+GK ++ + + AL + E + E +D A +KL E + +K ++
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Query: 1625 ENMMQQQKLTNISKQQAEQISILQTEVE 1652
E +Q + N K++ Q + + E E
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETE 1611
Score = 42.4 bits (98), Expect = 0.004
Identities = 88/462 (19%), Positives = 177/462 (38%), Gaps = 79/462 (17%)
Query: 1128 LEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQ-----FKDYEKKVKELNEERDKYRKSL 1182
L K + +L++ + AK D + +ER+Q K+ E+K +L EE++ ++ L
Sbjct: 844 LFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 903
Query: 1183 E------AELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLL--- 1233
+ AE ++++ + Q +E L + R + E Q + + +A +L
Sbjct: 904 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963
Query: 1234 --LDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSF 1291
L+EE ++R+K Q EK ++K +++ V + + L E K+++
Sbjct: 964 EQLEEEEAARQKL--------QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1015
Query: 1292 K-------------KEFSEIPGHQVDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSG 1338
K +++ ++ +L R + K + E G+
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 1339 KLNKDAFAQL-------------------------------MKAMDELD-NISNMPEGLD 1366
+ D AQ+ +K + EL+ +IS++ E LD
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135
Query: 1367 P--LVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELIL 1424
N +R E + +K + D L+ Q+ + E+ +++ E
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 1425 LQEEKVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKNIIE----DLNSVIRTQG 1480
E +V+ Q +++ +LE F+ D NK +E DL +R G
Sbjct: 1196 SHEAQVQEMRQKHAQ-AVEELTEQLEQFKRAKANLDK---NKQTLEKENADLAGELRVLG 1251
Query: 1481 QKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQ 1522
Q K + K + ++ +++ + E R +LN K +Q
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Score = 41.6 bits (96), Expect = 0.006
Identities = 64/283 (22%), Positives = 116/283 (40%), Gaps = 43/283 (15%)
Query: 1380 KVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTIQ 1439
KV+ +V ++ ++ LQK E ++K + E++ + + L EEK
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK---------N 897
Query: 1440 ILLKQGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQ 1499
+L +Q Q E E + E + K +E++ + A + E +D R Q
Sbjct: 898 LLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL-------HEMEARLEEEED---RGQQ 947
Query: 1500 IEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDK 1559
++ E KKM + DL ++ + + RQK E + +I +E I V+D
Sbjct: 948 LQAERKKMAQQMLDLEEQLEEEEAA-----RQKLQLE---KVTAEAKIKKLEDEILVMDD 999
Query: 1560 MHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAMGSKLT---- 1615
+ K + K L +++ L+ NL EE + N S ++
Sbjct: 1000 QNNKLSKERKLLEERISD-----------LTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048
Query: 1616 -CEKIVKERYENMMQQQKLTNISKQQAEQISILQTEVERLRMK 1657
+K K R E ++KL + EQI+ LQ ++ L+M+
Sbjct: 1049 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091
Score = 40.8 bits (94), Expect = 0.011
Identities = 103/535 (19%), Positives = 208/535 (38%), Gaps = 65/535 (12%)
Query: 714 KRFGGHLASEILDYYQKLLISLSSAMDK----ENHYLSTTPKVSVDLGSDSEHTKQKAST 769
KRF + + Y +K ++A DK +N + VDL + +
Sbjct: 1402 KRFQKEIENLTQQYEEK-----AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 770 DLSQDELVLTDVKKEIPWIQQKSQ---EAIKKEVNLFSKKRK-----EIKQGIKSLSKTI 821
D+L+ + + ++ + EA +KE S R E K+ ++ +K +
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 822 LNMMEE-----NDKLENIAKLDQQEFGLDLE------ELERLHDESQE-EVAKMIKDVEM 869
ME+ +D +N+ +L++ + L+ + +LE L DE Q E AK+ +V M
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1576
Query: 870 HNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENF-PMKARTVEELKELERVLQQK 928
L + +L + N + + +E+ +A K+LE L+
Sbjct: 1577 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1636
Query: 929 KIEAE-CLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFG 987
+++A+ +K R+E ++ +L K + + D + E ED + +
Sbjct: 1637 ELQADSAIKGREEAIK-----QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691
Query: 988 VDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVR 1047
++ L+ Q +L + E Q L K+ + + + +A +K AR+ +
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Query: 1048 IREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHW 1107
+ E ++E + + E+ L E TA K+ A++ + KE
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELAT--ERSTAQKN----ESARQQLERQNKELR 1805
Query: 1108 LLIQDASTRLRALMDMMGGVLEVKKEDILRMV-------------IPQPAFMAKPDAVWT 1154
+ + +++ LE K + V + Q K +
Sbjct: 1806 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV 1865
Query: 1155 EEERKQFKDYEK-------KVKELN---EERDKYRKSLEAELKKLQNSIQESTQA 1199
E+ERK + Y++ +VK+L EE ++ + + A +KLQ + E+T++
Sbjct: 1866 EDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 65.5 bits (158), Expect = 4e-10
Identities = 178/931 (19%), Positives = 378/931 (40%), Gaps = 103/931 (11%)
Query: 789 QQKSQEAIKKEVNLFSKKRKEIKQGIKSLSKTILNMMEENDKLENIAKLDQQEFGLDLEE 848
Q + +EA ++++ L K E K IK L IL M ++N+KL KL ++ + +
Sbjct: 965 QLEEEEAARQKLQL-EKVTAEAK--IKKLEDEILVMDDQNNKLSKERKLLEER----ISD 1017
Query: 849 LERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKEECWNSMAVKGRALKC------FHIP 902
L E +E+ + K H S L +K+E + ++ K FH
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH-- 1075
Query: 903 CVVENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRH------- 955
E + ELK ++ ++++++A +L EI + + +K I++
Sbjct: 1076 ---EQIADLQAQIAELK-MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1131
Query: 956 EEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDI 1015
E+ D E +K K L +L T+ ++Q EL ++ E+ ++ +LK
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ--EVTVLKKA 1189
Query: 1016 IYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERT 1075
+ + + ++ + + E+ + + +L+ + + E D R
Sbjct: 1190 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249
Query: 1076 LVVQDEEITAHKHIKPWHKAKELI--VNHEKEHWLLIQDASTRLRALMDMMGGVLEVKKE 1133
L +E+ HK K + +EL + + + D +L+ ++ + G+L +
Sbjct: 1250 LGQAKQEVE-HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1308
Query: 1134 DILRMV--IPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAELKKLQN 1191
+++ + + + +EE +Q + K+++L EER+ + L+ E++ QN
Sbjct: 1309 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1368
Query: 1192 SIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSR-EKFLNNYLT 1250
+ H+ L + + + K+ + A ++ EE R +K + N LT
Sbjct: 1369 --------LERHISTL-------NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN-LT 1412
Query: 1251 RKQHEKSQTSEAVRKSR----EDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDIL 1306
++ EK+ + + K++ ++LD DN +++ +++F ++ + +I
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK-QRKFDQLLAEEKNIS 1471
Query: 1307 YKLFKRRPRISKQKTHSET----------TSVVPFGELPGSGKLNKDAFAQLMKAMDEL- 1355
K R R + ET ++ EL + K+ K L+ + D++
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531
Query: 1356 DNISNMPEGLDPLVWNHFCM-TRRAKVENEQKVKQKAADLLEM---------ATFLQKRV 1405
N+ + + L M T+ ++E+E + + A LE+ LQ R
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591
Query: 1406 EEEEKVQQEIERVFHEL-ILLQEEKVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILI 1464
E+ E+ +++++R HE L++E+ + L + L+ +LE L+ AI
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE-----LQADSAIKG 1646
Query: 1465 NKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQIEWEHKKMEMERE-DLNQKAWDIQM 1523
+ I+ L ++ Q + + +++ I E++K E DL Q D+
Sbjct: 1647 REEAIKQLRK-LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 1524 LFFSRDRQKYLNEPNYEALISIQIG---------IMEQTIAVLDKMHKKNVENCKKLLKK 1574
+R + E E L S G +E IA L++ ++ N + + +
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1765
Query: 1575 LGKFSNQ-----KDIANYALSCNLREELVAVSERKDICNAMGSKL-TCEKIVKERYENMM 1628
+ K + Q ++A + E ER++ + SKL E VK ++++ +
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLERQN--KELRSKLHEMEGAVKSKFKSTI 1823
Query: 1629 Q--QQKLTNISKQQAEQISILQTEVERLRMK 1657
+ K+ + +Q ++ Q + L+ K
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854
Score = 63.2 bits (152), Expect = 2e-09
Identities = 147/785 (18%), Positives = 330/785 (42%), Gaps = 119/785 (15%)
Query: 911 KARTVEELKELERVLQQKKIEAECLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVK 970
K + + ++ E +Q K+ E + K R++ +A++ +K ++Q+H + EE+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQ--KAENELKELEQKHSQLTEEK-------- 896
Query: 971 YSNLPNYLLGSLSTDFGVDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAA 1030
N L L + + ++ L ++++++ +I+ +E +A
Sbjct: 897 -----NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL--------------HEMEAR 937
Query: 1031 YKQKEFEIARVKERNVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIK 1090
+++E +++ ++ + +LDLE + E+ E + L Q E++TA IK
Sbjct: 938 LEEEEDRGQQLQAERKKMAQQMLDLE-------EQLEEEEAARQKL--QLEKVTAEAKIK 988
Query: 1091 PWHKAKELIVNHE------KEHWLLIQDAS----------------TRLRALMDMMGGVL 1128
E++V + KE LL + S T+L+ + M L
Sbjct: 989 KLE--DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1046
Query: 1129 EV--KKEDILRMVIPQPAFMAKPDAVWTEEERKQFKDYEKKVKELNEERDKYRKSLEAEL 1186
EV KKE+ R + + + DA + +Q D + ++ EL + K + L+A L
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDA---SDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1103
Query: 1187 KKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLL------LDEELSS 1240
+L + I + A LK++ R ++ + QE+L A + L EEL +
Sbjct: 1104 ARLDDEIAQKNNA----LKKI--RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 1241 REKFLNNYLTRKQHEKSQTSEAVRKSRE-DLDVCKEHYDNLLAEDKVMDRSFKKEFSEIP 1299
+ L + L + + T + +R RE ++ V K+ D + + +++ ++
Sbjct: 1158 LKTELEDTL-----DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1212
Query: 1300 GHQVDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNI- 1358
+ L + + + + K K E + GEL G+ ++ + K ++ +
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 1359 SNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERV 1418
S +G RA+ E KV + ++ + L + + K+ +++ +
Sbjct: 1273 SKCSDG------------ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 1419 FHELILLQE---EKVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKNIIEDLNSV 1475
+L QE E+ R +LN++ K Q+E E L + + + +N+ ++++
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVS----TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 1476 -IRTQGQKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYL 1534
I+ KK + +D + +E K+ + E E+L Q+ + + ++ K
Sbjct: 1377 NIQLSDSKK-----KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431
Query: 1535 NEPNYEALISIQIGIMEQTIAVLDKMHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLR 1594
+ + L+ + + Q ++ L+K +K + + K+++++D A
Sbjct: 1432 LQQELDDLV-VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR---E 1487
Query: 1595 EELVAVSERKDICNAMGSKLTCE---KIVKERYENMMQQQKLTNISKQQAEQIS-ILQTE 1650
+E A+S + + A+ +K E K++K E+++ + + + E+ L+T+
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 1651 VERLR 1655
+E ++
Sbjct: 1548 MEEMK 1552
Score = 60.1 bits (144), Expect = 2e-08
Identities = 145/716 (20%), Positives = 292/716 (40%), Gaps = 112/716 (15%)
Query: 760 SEHTKQKASTDLSQDELVLTDVKKEIPWIQQKSQEAIKKEVNLFSKKRKEIKQGIKSLSK 819
++ T +K + DL+ + VL K+E+ ++K + + +E++ +
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV-----------QELQSKCSDGER 1280
Query: 820 TILNMMEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSYLAE 879
+ ++ KL+N ++E + + +E++ + K+ KDV + E
Sbjct: 1281 ARAELNDKVHKLQN-----------EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1329
Query: 880 LIKEECWNSMAVKGRALKCFHIPCVVENFPMKARTVEEL---KELERVLQQKKIEAECLK 936
L++EE + V + + E ++ + EE+ + LER + I+ K
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEE-----ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 937 LRKE----IVEA-QSGVKLIKQRHEEDDEEEEEE----DKTVKYSNLPNYLLGSLSTDFG 987
+ + VEA + G K ++ E ++ EE+ DK K N L L D
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444
Query: 988 VDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKE---FEIARVKER 1044
L+S+ L ++ K +Q++ + I + +A ++KE +AR E
Sbjct: 1445 NQRQLVSN---LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 1045 NVRIREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEK 1104
+ +E +LE + + E ED LV +++ K++ K+K +
Sbjct: 1502 ALEAKE---ELERTNKMLKAEMED-------LVSSKDDV--GKNVHELEKSKRALETQ-- 1547
Query: 1105 EHWLLIQDASTRLRALMDMMGGVLEVKKEDILRMVIPQPAFMAKPDA--VWTEEERKQFK 1162
+++ T+L L D + + K + M + F A EE+R+Q +
Sbjct: 1548 -----MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 1163 ----DYEKKVKELNEER---DKYRKSLEAELKKLQNSIQESTQAFDEHLKRLFERRVKAE 1215
+YE ++++ ++R +K LE +LK L+ + + +E +K+L R+++A+
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL--RKLQAQ 1660
Query: 1216 MVTNQEELKISNLAFSLLLDEELSSREKFLNNYLTRKQHEKSQTS------------EAV 1263
M Q E L++ +SR++ + T K++EK S A
Sbjct: 1661 MKDFQRE-----------LEDARASRDEI---FATAKENEKKAKSLEADLMQLQEDLAAA 1706
Query: 1264 RKSREDLDVCKEHYDNLLAEDKVMDRSFKKEFSEIPGHQVDILYKLFKRR-------PRI 1316
++R+ D+ KE LA + + E + + +L + + R+
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766
Query: 1317 SKQKTHSETTSVVPFGELPGSGKLNKDAFAQLMKAMDELDNISNMPEGLDPLVWNHFCMT 1376
K +E S E + K N+ A QL + EL + + EG +
Sbjct: 1767 RKATQQAEQLSNELATERSTAQK-NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 1377 RRAKV-ENEQKVKQKAADLLEMATFLQKRVEEEEKV--QQEIERVFHELILLQEEK 1429
AK+ + E++V+Q+A + L+++ ++ +++ Q E ER E Q EK
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881
Score = 56.2 bits (134), Expect = 3e-07
Identities = 175/868 (20%), Positives = 346/868 (39%), Gaps = 156/868 (17%)
Query: 824 MMEENDKLENIAKLDQQEFGLDLEELERLHDESQEEVAKMIKDVEMHNLAKSYLAELIKE 883
M + D+L+ K QQ+ +L+ELE+ H + EE K+ L E ++
Sbjct: 861 MQAKEDELQK-TKERQQKAENELKELEQKHSQLTEE--------------KNLLQEQLQA 905
Query: 884 ECWNSMAVKGRALKCFHIPCVVENFPMKARTVEELKELERVLQQKKIEAECLKLRKEIVE 943
E E M+ R + +ELE +L + + E + R + ++
Sbjct: 906 E----------------TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 949
Query: 944 AQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFGVDTSLLSSQLELHSRE 1003
A+ K+ +Q + +++ EEEE K QLE + E
Sbjct: 950 AER-KKMAQQMLDLEEQLEEEEAARQKL------------------------QLEKVTAE 984
Query: 1004 EKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVRIREIILDLELEEAVWQ 1063
KI + L+D I V +++ + K+++ R+ + + E E E+A
Sbjct: 985 AKIKK---LEDEI----LVMDDQNNKLSKERKLLEERISDLTTNLAE-----EEEKAKNL 1032
Query: 1064 PEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHWLLIQDASTRLRALMDM 1123
+ K + ++ + E+ K K +EL EK L DAS + D+
Sbjct: 1033 TKL----KNKHESMISELEVRLKKEEK---SRQEL----EKLKRKLEGDASDFHEQIADL 1081
Query: 1124 MGGVLEVKKEDILRMVIPQPAFMAKPDAVWTEEER-KQFKDYEKKVKELNEERDKYRKSL 1182
+ E+K + + Q A D + + K+ ++ E + +L E+ D R +
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER-AA 1140
Query: 1183 EAELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLLLDEELSSRE 1242
+ +K + + E +A L+ + + + + E +++ L LDEE S E
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL--KKALDEETRSHE 1198
Query: 1243 KFLNNYLTRKQH-----EKSQTSEAVRKSREDLDVCKEHYD----NLLAEDKVMDRS--- 1290
+ R++H E ++ E ++++ +LD K+ + +L E +V+ ++
Sbjct: 1199 AQVQE--MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256
Query: 1291 --FKKEFSEIPGHQVDILYKLFKRRPRISKQKTH---SETTSVVPFGELPGSGKLNKDAF 1345
KK+ E ++ +R K H +E SV +G LN +A
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV--------TGMLN-EAE 1307
Query: 1346 AQLMKAMDELDNISNMPEGLDPLVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRV 1405
+ +K ++ ++S+ + L+ + + + V K L E LQ ++
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELL--------QEETRQKLNVSTKLRQLEEERNSLQDQL 1359
Query: 1406 EEEEKVQQEIERVFHEL-ILLQEEKVRFQ-LNLTIQIL---LKQGQVELENFQLVLEYS- 1459
+EE + +Q +ER L I L + K + Q T++ L K+ Q E+EN E
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 1460 ---DAILINKNIIEDL--NSVIRTQGQKKVASMMESKDVHKRILQIEWEHKKM------E 1508
D + KN ++ + V+ Q+++ S +E K ++ Q+ E K + E
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK--QRKFDQLLAEEKNISSKYADE 1477
Query: 1509 MEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDKMHKKNVENC 1568
+R + + + + L +R ++ L ++ + +KM K +E+
Sbjct: 1478 RDRAEAEAREKETKALSLARALEEALE--------------AKEELERTNKMLKAEMEDL 1523
Query: 1569 KKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAM-GSKLTCE---KIVKERY 1624
+GK ++ + + AL + E + E +D A +KL E + +K ++
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Query: 1625 ENMMQQQKLTNISKQQAEQISILQTEVE 1652
E +Q + N K++ Q + + E E
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETE 1611
Score = 42.4 bits (98), Expect = 0.004
Identities = 88/462 (19%), Positives = 177/462 (38%), Gaps = 79/462 (17%)
Query: 1128 LEVKKEDILRMVIPQPAFMAKPDAVWTEEERKQ-----FKDYEKKVKELNEERDKYRKSL 1182
L K + +L++ + AK D + +ER+Q K+ E+K +L EE++ ++ L
Sbjct: 844 LFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 903
Query: 1183 E------AELKKLQNSIQESTQAFDEHLKRLFERRVKAEMVTNQEELKISNLAFSLL--- 1233
+ AE ++++ + Q +E L + R + E Q + + +A +L
Sbjct: 904 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963
Query: 1234 --LDEELSSREKFLNNYLTRKQHEKSQTSEAVRKSREDLDVCKEHYDNLLAEDKVMDRSF 1291
L+EE ++R+K Q EK ++K +++ V + + L E K+++
Sbjct: 964 EQLEEEEAARQKL--------QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1015
Query: 1292 K-------------KEFSEIPGHQVDILYKLFKRRPRISKQKTHSETTSVVPFGELPGSG 1338
K +++ ++ +L R + K + E G+
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 1339 KLNKDAFAQL-------------------------------MKAMDELD-NISNMPEGLD 1366
+ D AQ+ +K + EL+ +IS++ E LD
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135
Query: 1367 P--LVWNHFCMTRRAKVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELIL 1424
N +R E + +K + D L+ Q+ + E+ +++ E
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 1425 LQEEKVRFQLNLTIQILLKQGQVELENFQLVLEYSDAILINKNIIE----DLNSVIRTQG 1480
E +V+ Q +++ +LE F+ D NK +E DL +R G
Sbjct: 1196 SHEAQVQEMRQKHAQ-AVEELTEQLEQFKRAKANLDK---NKQTLEKENADLAGELRVLG 1251
Query: 1481 QKKVASMMESKDVHKRILQIEWEHKKMEMEREDLNQKAWDIQ 1522
Q K + K + ++ +++ + E R +LN K +Q
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Score = 41.6 bits (96), Expect = 0.006
Identities = 64/283 (22%), Positives = 116/283 (40%), Gaps = 43/283 (15%)
Query: 1380 KVENEQKVKQKAADLLEMATFLQKRVEEEEKVQQEIERVFHELILLQEEKVRFQLNLTIQ 1439
KV+ +V ++ ++ LQK E ++K + E++ + + L EEK
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK---------N 897
Query: 1440 ILLKQGQVELENFQLVLEYSDAILINKNIIEDLNSVIRTQGQKKVASMMESKDVHKRILQ 1499
+L +Q Q E E + E + K +E++ + A + E +D R Q
Sbjct: 898 LLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL-------HEMEARLEEEED---RGQQ 947
Query: 1500 IEWEHKKMEMEREDLNQKAWDIQMLFFSRDRQKYLNEPNYEALISIQIGIMEQTIAVLDK 1559
++ E KKM + DL ++ + + RQK E + +I +E I V+D
Sbjct: 948 LQAERKKMAQQMLDLEEQLEEEEAA-----RQKLQLE---KVTAEAKIKKLEDEILVMDD 999
Query: 1560 MHKKNVENCKKLLKKLGKFSNQKDIANYALSCNLREELVAVSERKDICNAMGSKLT---- 1615
+ K + K L +++ L+ NL EE + N S ++
Sbjct: 1000 QNNKLSKERKLLEERISD-----------LTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048
Query: 1616 -CEKIVKERYENMMQQQKLTNISKQQAEQISILQTEVERLRMK 1657
+K K R E ++KL + EQI+ LQ ++ L+M+
Sbjct: 1049 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091
Score = 40.8 bits (94), Expect = 0.011
Identities = 103/535 (19%), Positives = 208/535 (38%), Gaps = 65/535 (12%)
Query: 714 KRFGGHLASEILDYYQKLLISLSSAMDK----ENHYLSTTPKVSVDLGSDSEHTKQKAST 769
KRF + + Y +K ++A DK +N + VDL + +
Sbjct: 1402 KRFQKEIENLTQQYEEK-----AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 770 DLSQDELVLTDVKKEIPWIQQKSQ---EAIKKEVNLFSKKRK-----EIKQGIKSLSKTI 821
D+L+ + + ++ + EA +KE S R E K+ ++ +K +
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 822 LNMMEE-----NDKLENIAKLDQQEFGLDLE------ELERLHDESQE-EVAKMIKDVEM 869
ME+ +D +N+ +L++ + L+ + +LE L DE Q E AK+ +V M
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1576
Query: 870 HNLAKSYLAELIKEECWNSMAVKGRALKCFHIPCVVENF-PMKARTVEELKELERVLQQK 928
L + +L + N + + +E+ +A K+LE L+
Sbjct: 1577 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1636
Query: 929 KIEAE-CLKLRKEIVEAQSGVKLIKQRHEEDDEEEEEEDKTVKYSNLPNYLLGSLSTDFG 987
+++A+ +K R+E ++ +L K + + D + E ED + +
Sbjct: 1637 ELQADSAIKGREEAIK-----QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691
Query: 988 VDTSLLSSQLELHSREEKINQIILLKDIIYKVKTVFNNEFDAAYKQKEFEIARVKERNVR 1047
++ L+ Q +L + E Q L K+ + + + +A +K AR+ +
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Query: 1048 IREIILDLELEEAVWQPEFEDCEKPERTLVVQDEEITAHKHIKPWHKAKELIVNHEKEHW 1107
+ E ++E + + E+ L E TA K+ A++ + KE
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELAT--ERSTAQKN----ESARQQLERQNKELR 1805
Query: 1108 LLIQDASTRLRALMDMMGGVLEVKKEDILRMV-------------IPQPAFMAKPDAVWT 1154
+ + +++ LE K + V + Q K +
Sbjct: 1806 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV 1865
Query: 1155 EEERKQFKDYEK-------KVKELN---EERDKYRKSLEAELKKLQNSIQESTQA 1199
E+ERK + Y++ +VK+L EE ++ + + A +KLQ + E+T++
Sbjct: 1866 EDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,042,710
Number of Sequences: 37866
Number of extensions: 2768805
Number of successful extensions: 20870
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 48
Number of HSP's successfully gapped in prelim test: 669
Number of HSP's that attempted gapping in prelim test: 16090
Number of HSP's gapped (non-prelim): 3806
length of query: 1665
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1549
effective length of database: 13,855,062
effective search space: 21461491038
effective search space used: 21461491038
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.