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Search of human proteins with 94538370
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94538370 DnaJ (Hsp40) homolog, subfamily C, member 2 isoform
1 [Homo sapiens]
(621 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94538370 DnaJ (Hsp40) homolog, subfamily C, member 2 isoform ... 1248 0.0
gi|193788632 DnaJ (Hsp40) homolog, subfamily C, member 2 isoform... 1117 0.0
gi|68077168 DnaJ homology subfamily A member 5 isoform 1 [Homo s... 99 1e-20
gi|68077166 DnaJ homology subfamily A member 5 isoform 2 [Homo s... 99 1e-20
gi|21361912 DnaJ (Hsp40) homolog, subfamily C, member 1 [Homo sa... 78 3e-14
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 69 1e-11
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 69 1e-11
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 68 2e-11
gi|148746195 trichohyalin [Homo sapiens] 67 4e-11
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 67 6e-11
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 66 1e-10
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 65 2e-10
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 65 2e-10
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 64 3e-10
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 63 7e-10
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 63 7e-10
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 63 9e-10
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 62 2e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 62 2e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 62 2e-09
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 62 2e-09
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 62 2e-09
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 62 2e-09
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 62 2e-09
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 62 2e-09
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 61 3e-09
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 61 4e-09
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 61 4e-09
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 61 4e-09
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 61 4e-09
>gi|94538370 DnaJ (Hsp40) homolog, subfamily C, member 2 isoform 1
[Homo sapiens]
Length = 621
Score = 1248 bits (3229), Expect = 0.0
Identities = 621/621 (100%), Positives = 621/621 (100%)
Query: 1 MLLLPSAADGRGTAITHALTSASTLCQVEPVGRWFEAFVKRRNRNASASFQELEDKKELS 60
MLLLPSAADGRGTAITHALTSASTLCQVEPVGRWFEAFVKRRNRNASASFQELEDKKELS
Sbjct: 1 MLLLPSAADGRGTAITHALTSASTLCQVEPVGRWFEAFVKRRNRNASASFQELEDKKELS 60
Query: 61 EESEDEELQLEEFPMLKTLDPKDWKNQDHYAVLGLGHVRYKATQRQIKAAHKAMVLKHHP 120
EESEDEELQLEEFPMLKTLDPKDWKNQDHYAVLGLGHVRYKATQRQIKAAHKAMVLKHHP
Sbjct: 61 EESEDEELQLEEFPMLKTLDPKDWKNQDHYAVLGLGHVRYKATQRQIKAAHKAMVLKHHP 120
Query: 121 DKRKAAGEPIKEGDNDYFTCITKAYEMLSDPVKRRAFNSVDPTFDNSVPSKSEAKDNFFE 180
DKRKAAGEPIKEGDNDYFTCITKAYEMLSDPVKRRAFNSVDPTFDNSVPSKSEAKDNFFE
Sbjct: 121 DKRKAAGEPIKEGDNDYFTCITKAYEMLSDPVKRRAFNSVDPTFDNSVPSKSEAKDNFFE 180
Query: 181 VFTPVFERNSRWSNKKNVPKLGDMNSSFEDVDIFYSFWYNFDSWREFSYLDEEEKEKAEC 240
VFTPVFERNSRWSNKKNVPKLGDMNSSFEDVDIFYSFWYNFDSWREFSYLDEEEKEKAEC
Sbjct: 181 VFTPVFERNSRWSNKKNVPKLGDMNSSFEDVDIFYSFWYNFDSWREFSYLDEEEKEKAEC 240
Query: 241 RDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAKAE 300
RDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAKAE
Sbjct: 241 RDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAKAE 300
Query: 301 AKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSC 360
AKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSC
Sbjct: 301 AKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSC 360
Query: 361 KTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAALEKQIEEINE 420
KTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAALEKQIEEINE
Sbjct: 361 KTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAALEKQIEEINE 420
Query: 421 QIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNLFPAGTNSRWEVI 480
QIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNLFPAGTNSRWEVI
Sbjct: 421 QIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNLFPAGTNSRWEVI 480
Query: 481 ANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKKAFDKFKKEHGVVPQADNATP 540
ANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKKAFDKFKKEHGVVPQADNATP
Sbjct: 481 ANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKKAFDKFKKEHGVVPQADNATP 540
Query: 541 SERFEGPYTDFTPWTTEEQKLLEQALKTYPVNTPERWEKIAEAVPGRTKKDCMKRYKELV 600
SERFEGPYTDFTPWTTEEQKLLEQALKTYPVNTPERWEKIAEAVPGRTKKDCMKRYKELV
Sbjct: 541 SERFEGPYTDFTPWTTEEQKLLEQALKTYPVNTPERWEKIAEAVPGRTKKDCMKRYKELV 600
Query: 601 EMVKAKKAAQEQVLNASRAKK 621
EMVKAKKAAQEQVLNASRAKK
Sbjct: 601 EMVKAKKAAQEQVLNASRAKK 621
>gi|193788632 DnaJ (Hsp40) homolog, subfamily C, member 2 isoform 2
[Homo sapiens]
Length = 568
Score = 1117 bits (2889), Expect = 0.0
Identities = 568/621 (91%), Positives = 568/621 (91%), Gaps = 53/621 (8%)
Query: 1 MLLLPSAADGRGTAITHALTSASTLCQVEPVGRWFEAFVKRRNRNASASFQELEDKKELS 60
MLLLPSAADGRGTAITHALTSASTLCQVEPVGRWFEAFVKRRNRNASASFQELEDKKELS
Sbjct: 1 MLLLPSAADGRGTAITHALTSASTLCQVEPVGRWFEAFVKRRNRNASASFQELEDKKELS 60
Query: 61 EESEDEELQLEEFPMLKTLDPKDWKNQDHYAVLGLGHVRYKATQRQIKAAHKAMVLKHHP 120
EESEDEELQLEEFPMLKTLDPKDWKNQDHYAVLGLGHVRYKATQRQIKAAHKAMVLKHHP
Sbjct: 61 EESEDEELQLEEFPMLKTLDPKDWKNQDHYAVLGLGHVRYKATQRQIKAAHKAMVLKHHP 120
Query: 121 DKRKAAGEPIKEGDNDYFTCITKAYEMLSDPVKRRAFNSVDPTFDNSVPSKSEAKDNFFE 180
DKRKAAGEPIKEGDNDYFTCITKAYEMLSDPVKRRAFNSVDPTFDNSVPSKSEAKDNFFE
Sbjct: 121 DKRKAAGEPIKEGDNDYFTCITKAYEMLSDPVKRRAFNSVDPTFDNSVPSKSEAKDNFFE 180
Query: 181 VFTPVFERNSRWSNKKNVPKLGDMNSSFEDVDIFYSFWYNFDSWREFSYLDEEEKEKAEC 240
VFTPVFERNSRWSNKKNVPKLGDMNSSFEDVDIFYSFWYNFDSWREFSYLDEEEKEKAEC
Sbjct: 181 VFTPVFERNSRWSNKKNVPKLGDMNSSFEDVDIFYSFWYNFDSWREFSYLDEEEKEKAEC 240
Query: 241 RDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAKAE 300
RDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAKAE
Sbjct: 241 RDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAKAE 300
Query: 301 AKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSC 360
AKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSC
Sbjct: 301 AKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSC 360
Query: 361 KTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAALEKQIEEINE 420
K IEEINE
Sbjct: 361 K-----------------------------------------------------IEEINE 367
Query: 421 QIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNLFPAGTNSRWEVI 480
QIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNLFPAGTNSRWEVI
Sbjct: 368 QIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNLFPAGTNSRWEVI 427
Query: 481 ANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKKAFDKFKKEHGVVPQADNATP 540
ANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKKAFDKFKKEHGVVPQADNATP
Sbjct: 428 ANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKKAFDKFKKEHGVVPQADNATP 487
Query: 541 SERFEGPYTDFTPWTTEEQKLLEQALKTYPVNTPERWEKIAEAVPGRTKKDCMKRYKELV 600
SERFEGPYTDFTPWTTEEQKLLEQALKTYPVNTPERWEKIAEAVPGRTKKDCMKRYKELV
Sbjct: 488 SERFEGPYTDFTPWTTEEQKLLEQALKTYPVNTPERWEKIAEAVPGRTKKDCMKRYKELV 547
Query: 601 EMVKAKKAAQEQVLNASRAKK 621
EMVKAKKAAQEQVLNASRAKK
Sbjct: 548 EMVKAKKAAQEQVLNASRAKK 568
>gi|68077168 DnaJ homology subfamily A member 5 isoform 1 [Homo
sapiens]
Length = 576
Score = 99.0 bits (245), Expect = 1e-20
Identities = 98/404 (24%), Positives = 181/404 (44%), Gaps = 69/404 (17%)
Query: 89 HYAVLGLGHVRYKATQRQIKAAHKAMVLKHHPDKRKAAGEPIKEGDNDYFTCITKAYEML 148
HY LG VR A++ ++K A++ + LK HPDK E F I AY++L
Sbjct: 4 HYEALG---VRRDASEEELKKAYRKLALKWHPDKNLDNAAEAAE----QFKLIQAAYDVL 56
Query: 149 SDPVKRRAFNS-----VDPTFDNSVPSKS----------------EAKDNFFEVFTPVFE 187
SDP +R +++ + FD S + + F+ V+ VFE
Sbjct: 57 SDPQERAWYDNHREALLKGGFDGEYQDDSLDLLRYFTVTCYSGYGDDEKGFYTVYRNVFE 116
Query: 188 RNSRWSNKK-------NVPKLGDMNSSFEDV-DIFYSFWYNFDSWREFSYLDEEEKEKAE 239
++ + + P GD S ++ V FY++W +F + + F++ +E + +A
Sbjct: 117 MIAKEELESVLEEEVDDFPTFGDSQSDYDTVVHPFYAYWQSFCTQKNFAWKEEYDTRQAS 176
Query: 240 CRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAKA 299
R E+R +EK+N+ R + +KE+ +R LV D R++ ++ + ++ AEK KA
Sbjct: 177 NRWEKRAMEKENKKIRDKARKEKNELVRQLVAFIRKRDKRVQAHRKLVE-EQNAEKARKA 235
Query: 300 EAKRKEQEAKEK------QRQAELEAARLAKEKEEEEVRQQALL--AKKEKDIQKKAIKK 351
E R++Q+ K+ + Q+ + A L KE +E E R + E ++++ +K
Sbjct: 236 EEMRRQQKLKQAKLVEQYREQSWMTMANLEKELQEMEARYEKEFGDGSDENEMEEHELKD 295
Query: 352 ERQKLRNSCKTWNHFSDNEAERVKMMEEVE-KLCDRLELASLQCLNETLTSCTKEVGKAA 410
E + +EAE ++ +++ CD+ N + +E+ A
Sbjct: 296 EE----------DGKDSDEAEDAELYDDLYCPACDKSFKTEKAMKNHEKSKKHREM-VAL 344
Query: 411 LEKQIEEINEQIRK------------EKEEAEARMRQASKNTEK 442
L++Q+EE E + E+E +A ++ SK +K
Sbjct: 345 LKQQLEEEEENFSRPQIDENPLDDNSEEEMEDAPKQKLSKKQKK 388
Score = 40.0 bits (92), Expect = 0.006
Identities = 38/143 (26%), Positives = 60/143 (41%), Gaps = 14/143 (9%)
Query: 219 YNFDSWREFSYLDEE--------EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLV 270
Y SW + L++E EKE + DE E + + + +E L
Sbjct: 253 YREQSWMTMANLEKELQEMEARYEKEFGDGSDENEMEEHELKDEEDGKDSDEAEDAE-LY 311
Query: 271 DNAY--SCDPRIKK---FKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKE 325
D+ Y +CD K K EK+KK E A + + +E+E + Q + E
Sbjct: 312 DDLYCPACDKSFKTEKAMKNHEKSKKHREMVALLKQQLEEEEENFSRPQIDENPLDDNSE 371
Query: 326 KEEEEVRQQALLAKKEKDIQKKA 348
+E E+ +Q L K++K QK A
Sbjct: 372 EEMEDAPKQKLSKKQKKKKQKPA 394
>gi|68077166 DnaJ homology subfamily A member 5 isoform 2 [Homo
sapiens]
Length = 531
Score = 99.0 bits (245), Expect = 1e-20
Identities = 98/404 (24%), Positives = 181/404 (44%), Gaps = 69/404 (17%)
Query: 89 HYAVLGLGHVRYKATQRQIKAAHKAMVLKHHPDKRKAAGEPIKEGDNDYFTCITKAYEML 148
HY LG VR A++ ++K A++ + LK HPDK E F I AY++L
Sbjct: 4 HYEALG---VRRDASEEELKKAYRKLALKWHPDKNLDNAAEAAE----QFKLIQAAYDVL 56
Query: 149 SDPVKRRAFNS-----VDPTFDNSVPSKS----------------EAKDNFFEVFTPVFE 187
SDP +R +++ + FD S + + F+ V+ VFE
Sbjct: 57 SDPQERAWYDNHREALLKGGFDGEYQDDSLDLLRYFTVTCYSGYGDDEKGFYTVYRNVFE 116
Query: 188 RNSRWSNKK-------NVPKLGDMNSSFEDV-DIFYSFWYNFDSWREFSYLDEEEKEKAE 239
++ + + P GD S ++ V FY++W +F + + F++ +E + +A
Sbjct: 117 MIAKEELESVLEEEVDDFPTFGDSQSDYDTVVHPFYAYWQSFCTQKNFAWKEEYDTRQAS 176
Query: 240 CRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAKA 299
R E+R +EK+N+ R + +KE+ +R LV D R++ ++ + ++ AEK KA
Sbjct: 177 NRWEKRAMEKENKKIRDKARKEKNELVRQLVAFIRKRDKRVQAHRKLVE-EQNAEKARKA 235
Query: 300 EAKRKEQEAKEK------QRQAELEAARLAKEKEEEEVRQQALL--AKKEKDIQKKAIKK 351
E R++Q+ K+ + Q+ + A L KE +E E R + E ++++ +K
Sbjct: 236 EEMRRQQKLKQAKLVEQYREQSWMTMANLEKELQEMEARYEKEFGDGSDENEMEEHELKD 295
Query: 352 ERQKLRNSCKTWNHFSDNEAERVKMMEEVE-KLCDRLELASLQCLNETLTSCTKEVGKAA 410
E + +EAE ++ +++ CD+ N + +E+ A
Sbjct: 296 EE----------DGKDSDEAEDAELYDDLYCPACDKSFKTEKAMKNHEKSKKHREM-VAL 344
Query: 411 LEKQIEEINEQIRK------------EKEEAEARMRQASKNTEK 442
L++Q+EE E + E+E +A ++ SK +K
Sbjct: 345 LKQQLEEEEENFSRPQIDENPLDDNSEEEMEDAPKQKLSKKQKK 388
Score = 40.0 bits (92), Expect = 0.006
Identities = 38/143 (26%), Positives = 60/143 (41%), Gaps = 14/143 (9%)
Query: 219 YNFDSWREFSYLDEE--------EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLV 270
Y SW + L++E EKE + DE E + + + +E L
Sbjct: 253 YREQSWMTMANLEKELQEMEARYEKEFGDGSDENEMEEHELKDEEDGKDSDEAEDAE-LY 311
Query: 271 DNAY--SCDPRIKK---FKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKE 325
D+ Y +CD K K EK+KK E A + + +E+E + Q + E
Sbjct: 312 DDLYCPACDKSFKTEKAMKNHEKSKKHREMVALLKQQLEEEEENFSRPQIDENPLDDNSE 371
Query: 326 KEEEEVRQQALLAKKEKDIQKKA 348
+E E+ +Q L K++K QK A
Sbjct: 372 EEMEDAPKQKLSKKQKKKKQKPA 394
>gi|21361912 DnaJ (Hsp40) homolog, subfamily C, member 1 [Homo
sapiens]
Length = 554
Score = 77.8 bits (190), Expect = 3e-14
Identities = 42/110 (38%), Positives = 67/110 (60%), Gaps = 1/110 (0%)
Query: 502 KAKSLQKLDPHQKDDINKKAFDKFKKEHGVVPQADNATP-SERFEGPYTDFTPWTTEEQK 560
+ K + L+ K + +K+ K +K+ + Q +++ S R E + PWT +QK
Sbjct: 444 RRKPARLLEATAKPEPEEKSRAKRQKDFDIAEQNESSDEESLRKERARSAEEPWTQNQQK 503
Query: 561 LLEQALKTYPVNTPERWEKIAEAVPGRTKKDCMKRYKELVEMVKAKKAAQ 610
LLE AL+ YP + +RW+KIA VP ++K+DC+ RYK LVE+V+ KK A+
Sbjct: 504 LLELALQQYPRGSSDRWDKIARCVPSKSKEDCIARYKLLVELVQKKKQAK 553
Score = 41.2 bits (95), Expect = 0.003
Identities = 31/93 (33%), Positives = 43/93 (46%), Gaps = 22/93 (23%)
Query: 415 IEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNLFPAGTN 474
IEEI EQ+ + E R R K + W+E+DL L +++ FP GT
Sbjct: 305 IEEIEEQM---DDWLENRNRTQKKQAPE-----------WTEEDLSQLTRSMVKFPGGTP 350
Query: 475 SRWEVIANYMNIHSSSGVKRTAKDVIGKAKSLQ 507
RWE IA+ + R+ DV KAK L+
Sbjct: 351 GRWEKIAHELG--------RSVTDVTTKAKQLK 375
Score = 40.0 bits (92), Expect = 0.006
Identities = 49/222 (22%), Positives = 89/222 (40%), Gaps = 47/222 (21%)
Query: 411 LEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIK------ 464
LEKQ++E+ + ++EK++ + SK+ + S G SE + +LL+K
Sbjct: 175 LEKQLDELLSRKKREKKK-----KTGSKSVDVSKLGA-------SEKNERLLMKPQWHDL 222
Query: 465 -----------AVNLFPAGTNSRWEVIANYMNIH---SSSGVKRTAKDVIGKAKSLQKLD 510
+ P + A Y + RT + + K K ++K
Sbjct: 223 LPCKLGIWFCLTLKALPHLIQDAGQFYAKYKETRLKEKEDALTRTELETLQKQKKVKKPK 282
Query: 511 PH-----QKDDINKKAFDKFKKEHGVVPQAD----NATPSERFEGPYTDFTPWTTEEQKL 561
P + +++D + Q D N +++ + P WT E+
Sbjct: 283 PEFPVYTPLETTYIQSYDHGTSIEEIEEQMDDWLENRNRTQKKQAP-----EWTEEDLSQ 337
Query: 562 LEQALKTYPVNTPERWEKIAEAVPGRTKKDCMKRYKELVEMV 603
L +++ +P TP RWEKIA + GR+ D + K+L + V
Sbjct: 338 LTRSMVKFPGGTPGRWEKIAHEL-GRSVTDVTTKAKQLKDSV 378
Score = 32.0 bits (71), Expect = 1.7
Identities = 22/105 (20%), Positives = 47/105 (44%), Gaps = 7/105 (6%)
Query: 410 ALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNLF 469
A K E + +++K+ A ++S + + W+++ +LL A+ +
Sbjct: 453 ATAKPEPEEKSRAKRQKDFDIAEQNESSDEESLRKERARSAEEPWTQNQQKLLELALQQY 512
Query: 470 PAGTNSRWEVIANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQK 514
P G++ RW+ IA + ++ +D I + K L +L +K
Sbjct: 513 PRGSSDRWDKIARCV-------PSKSKEDCIARYKLLVELVQKKK 550
Score = 31.6 bits (70), Expect = 2.3
Identities = 20/71 (28%), Positives = 33/71 (46%), Gaps = 9/71 (12%)
Query: 90 YAVLGLGHVRYKATQRQIKAAHKAMVLKHHPDKRKAAGEPIKEGDNDYFTCITKAYEMLS 149
Y LG V+ A+ I+ A++ + L HPDK K E F + YE+L
Sbjct: 67 YQFLG---VQQDASSADIRKAYRKLSLTLHPDKNK------DENAETQFRQLVAIYEVLK 117
Query: 150 DPVKRRAFNSV 160
D +R+ ++ +
Sbjct: 118 DDERRQRYDDI 128
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 69.3 bits (168), Expect = 1e-11
Identities = 52/221 (23%), Positives = 120/221 (54%), Gaps = 24/221 (10%)
Query: 224 WREFSYLDEEEKEKAECRDERRWIEKQNRATRAQ--RKKEEMNRIRTLVDNAYSCDPRIK 281
WR+ + E+E EK ++E+ W +++ + + R++E+M+ + + + K
Sbjct: 513 WRQEEKIREQE-EKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDK 571
Query: 282 KFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKE 341
+++EEK +++ EK + E K +EQE K ++++ ++ K+EE++R+Q +++
Sbjct: 572 MWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKM-------WKQEEKIREQ----EEK 620
Query: 342 KDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTS 401
Q++ I+++ +K+R + + + KM E+ EK+C++ E +Q ET+
Sbjct: 621 IQEQEEKIREQEEKIREQEEM------TQEQEEKMGEQEEKMCEQEE--KMQEQEETMWR 672
Query: 402 CTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
+++ + EK+I E E+IR+++E + + + + EK
Sbjct: 673 QEEKIREQ--EKKIREQEEKIREQEEMMQEQEEKMWEQEEK 711
Score = 64.3 bits (155), Expect = 3e-10
Identities = 54/232 (23%), Positives = 110/232 (47%), Gaps = 40/232 (17%)
Query: 218 WYNFDSWREFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCD 277
W + R + E++EK ++E W +++ + + E+ +IR L + + +
Sbjct: 345 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 404
Query: 278 PRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAK-----EKQRQAELEAARLAKE--KEEEE 330
K +E+E+ K++ E+K + + KR+EQEAK EK R+ E + K+ ++EE+
Sbjct: 405 ----KIREQEE-KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK 459
Query: 331 VRQQALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELA 390
+ +Q + ++EK +++ + ++ +K+ + W ++ KM E+ EK+ + E
Sbjct: 460 IHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWR-------QKEKMHEQEEKIRKQEE-- 510
Query: 391 SLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
+ +Q E+I EQ K +E+ E RQ K E+
Sbjct: 511 -------------------KVWRQEEKIREQEEKIREQEEKMWRQEEKIREQ 543
Score = 59.3 bits (142), Expect = 1e-08
Identities = 48/228 (21%), Positives = 113/228 (49%), Gaps = 21/228 (9%)
Query: 224 WREFSYLDEEEKEKAECRDERRWIEKQN----RATRAQRKKEEMNRIRTLVDNAYSCDP- 278
WR+ + E+E EK ++++ W +++ R + K++E + + + +
Sbjct: 433 WRQEEKIREQE-EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEI 491
Query: 279 ---RIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVR-QQ 334
+ K ++EEK +K+ EK + E K +EQE K ++++ ++ ++EE++R Q+
Sbjct: 492 WRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKM-------WRQEEKIREQE 544
Query: 335 ALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQC 394
+ ++EK +++ I +E ++ K W + K+ + EK+ ++ E Q
Sbjct: 545 EMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQ- 603
Query: 395 LNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
E + +++ + E++I+E E+IR+++E+ + + EK
Sbjct: 604 -EEKMWKQEEKIREQ--EEKIQEQEEKIREQEEKIREQEEMTQEQEEK 648
Score = 55.1 bits (131), Expect = 2e-07
Identities = 48/222 (21%), Positives = 108/222 (48%), Gaps = 13/222 (5%)
Query: 230 LDEEEKEKAECRDER--RWIEK---QNRATRAQRKK--EEMNRIRTLVDNAYSCDPRIKK 282
L+++++EK ++E+ W EK Q R Q +K E+ ++R + + + ++++
Sbjct: 294 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 353
Query: 283 FKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEK 342
+EE +KE + + + E +++E +Q + E +E EE+ Q+ + ++EK
Sbjct: 354 -QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 412
Query: 343 DIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSC 402
+++ I+++ ++ K W + K+ E+ +K+ + E Q E +
Sbjct: 413 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ---EKIREE 469
Query: 403 TKEVGKAALEKQIEEINEQ--IRKEKEEAEARMRQASKNTEK 442
K + + +Q E+I+EQ I ++KE+ + + K EK
Sbjct: 470 EKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEK 511
Score = 47.4 bits (111), Expect = 4e-05
Identities = 32/171 (18%), Positives = 89/171 (52%), Gaps = 21/171 (12%)
Query: 224 WREFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKF 283
WR+ + E+E+++ E ++E+ W +++ + ++ +E+ +IR + + ++
Sbjct: 587 WRQEEKIREQEEKRQE-QEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQE- 644
Query: 284 KEEEKAKKEAEKKAKAEAKRKEQEA---------KEKQRQAELEAARLAKEKEEEEVRQQ 334
+EEK ++ EK + E K +EQE +E++++ + ++ +++E + +++
Sbjct: 645 -QEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEE 703
Query: 335 ALLAKKEK--DIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKL 383
+ ++EK + ++K ++E + R K W + V++ ++ EK+
Sbjct: 704 KMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE-------QEVRLRQQEEKM 747
Score = 46.6 bits (109), Expect = 7e-05
Identities = 71/347 (20%), Positives = 147/347 (42%), Gaps = 43/347 (12%)
Query: 279 RIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLA 338
R+ + +EE+ ++E EK + E K +EQE K ++++ ++ +E+EE+ RQ+ ++
Sbjct: 293 RLNQQQEEKMWRQE-EKIQEWEEKIQEQEEKIREQEEKI------REQEEKMRRQEEMMW 345
Query: 339 KKEKDIQKK---AIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCL 395
+KE+ ++++ +KE + R W + M E+ EK+ + L
Sbjct: 346 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRE---------L 396
Query: 396 NETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWS 455
E + K + ++ E+I EQ +++++EA+ RQ K E+ K W
Sbjct: 397 EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK-MWRQEEKIREQEEKIREQEKKMWR 455
Query: 456 EDDLQLLIKAVNLFPAGTNSRWEVIANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKD 515
+++ ++ + + E+ IH + R QK H+++
Sbjct: 456 QEE-KIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWR------------QKEKMHEQE 502
Query: 516 DINKKAFDK-FKKEHGVVPQADNATPSERFEGPYTDFTPWTTEEQKLLEQALKTYPVNTP 574
+ +K +K +++E + Q + E W +E+K+ EQ
Sbjct: 503 EKIRKQEEKVWRQEEKIREQEEKIREQEE--------KMW-RQEEKIREQEEMWREEEKM 553
Query: 575 ERWEKIAEAVPGRTKKDCMKRYKELVEMVKAKKAAQEQVLNASRAKK 621
EKI E + ++D M R +E + + K QE+ + K+
Sbjct: 554 HEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKR 600
Score = 40.0 bits (92), Expect = 0.006
Identities = 23/101 (22%), Positives = 55/101 (54%), Gaps = 3/101 (2%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQRK-KEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKE 292
E+E+ C E + E++ R + K +E+ +IR + + +++ +EEK ++
Sbjct: 651 EQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQE--QEEKMWEQ 708
Query: 293 AEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQ 333
EK + E K +EQE K ++++ ++ + ++EE++++
Sbjct: 709 EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 34.7 bits (78), Expect = 0.27
Identities = 24/92 (26%), Positives = 46/92 (50%), Gaps = 12/92 (13%)
Query: 233 EEKEKAECRDERRW-----IEKQNRATRAQ----RKKEEM---NRIRTLVDNAYSCDPRI 280
E++EK + ++E W I +Q + R Q R++EEM + C+
Sbjct: 658 EQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 717
Query: 281 KKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQ 312
K ++EEK +++ EK + E + ++QE K ++
Sbjct: 718 KMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 68.9 bits (167), Expect = 1e-11
Identities = 59/228 (25%), Positives = 119/228 (52%), Gaps = 27/228 (11%)
Query: 233 EEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKE 292
E++EK ++E W +++ + + E+ +IR L + + + K +E+E+ K++
Sbjct: 313 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE----KIREQEE-KRQ 367
Query: 293 AEKKAKAEAKRKEQEAK-----EKQRQAE---LEAARLAKEKEEEEVRQQALLAKKEKDI 344
E+K + + KR+EQEAK EK R+ E E + +E+EE+ Q+ + ++E+++
Sbjct: 368 EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEM 427
Query: 345 QKKAIKKERQ--KLRNSCKTWNHFSDNEAERVKMMEEVE--------KLCDRLELASLQC 394
Q++ K RQ K+R K + E+ +MM+E E K+C+ + A +Q
Sbjct: 428 QEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCE--QEAKMQE 485
Query: 395 LNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
E + +++ + EK+I E E+IR+++E + + + + EK
Sbjct: 486 QEEKMRRQEEKIREQ--EKKIREQEEKIREQEEMMQEQEEKMWEQEEK 531
Score = 59.3 bits (142), Expect = 1e-08
Identities = 45/221 (20%), Positives = 107/221 (48%), Gaps = 54/221 (24%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK 284
RE + +E++EK ++E+ W +++ + ++ + + +IR + +I++
Sbjct: 400 REQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIRE-- 457
Query: 285 EEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDI 344
+EE +++ EK + E K EQEAK ++++ ++ ++EE++R+
Sbjct: 458 QEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKM-------RRQEEKIRE----------- 499
Query: 345 QKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTK 404
Q+K I+++ +K+R + + + KM E+ EK+C++
Sbjct: 500 QEKKIREQEEKIREQEEMM------QEQEEKMWEQEEKMCEQ------------------ 535
Query: 405 EVGKAALEKQIEEINEQIRKEKE---EAEARMRQASKNTEK 442
E++++E E++R+++E E E R+RQ + ++
Sbjct: 536 -------EEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 51.6 bits (122), Expect = 2e-06
Identities = 50/257 (19%), Positives = 120/257 (46%), Gaps = 27/257 (10%)
Query: 224 WREFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKF 283
W + EE+ + E + + R + Q + + + ++E+M R ++ + K
Sbjct: 279 WNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMM-----WEKEEKMR 333
Query: 284 KEEEKAKKEAEKKAKAEAKRKEQEA--KEKQRQAELEAARLAKEKEEEEV---RQQALLA 338
++EE ++ EK + E K EQE ++++++ E E R ++++E+E RQ+ +
Sbjct: 334 RQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 393
Query: 339 KKEKDI--QKKAIKKERQKL-RNSCKTWNHFSDNEAERVKMMEEVEKLCD-----RLELA 390
++E+ I Q++ ++++ +K+ K W + + + KM + EK+ + R +
Sbjct: 394 EQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEE 453
Query: 391 SLQCLNETLTSCTKEVG---------KAALEKQIEEINEQIRKEKEEAEARMRQASKNTE 441
++ E + +++G +A +++Q E++ Q K +E+ + Q K E
Sbjct: 454 KIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIRE 513
Query: 442 KSTGGGGNGSKNWSEDD 458
+ K W +++
Sbjct: 514 QEEMMQEQEEKMWEQEE 530
Score = 51.2 bits (121), Expect = 3e-06
Identities = 30/136 (22%), Positives = 69/136 (50%), Gaps = 10/136 (7%)
Query: 224 WREFSYLDEEE----KEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPR 279
W + + E+E +++ + R++ + I +Q R Q + + + C+
Sbjct: 421 WEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQE 480
Query: 280 IKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAK 339
K ++EEK +++ EK + E K +EQE K ++++ + +E+EE+ Q+ + +
Sbjct: 481 AKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE------EMMQEQEEKMWEQEEKMCE 534
Query: 340 KEKDIQKKAIKKERQK 355
+E+ +Q++ K RQ+
Sbjct: 535 QEEKMQEQEEKMRRQE 550
Score = 50.8 bits (120), Expect = 4e-06
Identities = 48/222 (21%), Positives = 102/222 (45%), Gaps = 18/222 (8%)
Query: 235 KEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAE 294
K +A+ + W NR Q+++E+M R + R +K +E+E+ +E E
Sbjct: 268 KLQAQVEENELW----NRLN--QQQEEKMWRQEEKIQE------REEKIQEQEEKIREQE 315
Query: 295 KKAKAEAKRKEQEAKEKQRQAEL--EAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKE 352
+K + + + ++ ++ +RQ E+ E +E EE+ Q+ + ++EK +++ I+++
Sbjct: 316 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 375
Query: 353 RQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEV--GKAA 410
++ K W + K+ E+ E + ++ E Q E + +E+ +
Sbjct: 376 EKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQ--EEKMWEQEEEMQEQEEK 433
Query: 411 LEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSK 452
+ +Q E+I EQ +K +E+ E Q E+ G K
Sbjct: 434 MRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGK 475
Score = 43.5 bits (101), Expect = 6e-04
Identities = 47/246 (19%), Positives = 114/246 (46%), Gaps = 42/246 (17%)
Query: 231 DEEEKEK-AECRDERRWIEKQNRATRAQRK--KEEMNRIRTLVDNAY------------- 274
DEE KEK A+ +++ + +E + + K K ++ R + L+
Sbjct: 204 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 263
Query: 275 SCDPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQ 334
S +++ EE + ++ + + R+E++ +E++ + + + ++ +E+EE+ RQ+
Sbjct: 264 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKI-REQEEKMRRQE 322
Query: 335 ALLAKKEKDI--QKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASL 392
++ +KE+ + Q++ + ++ +K+R + E+ K+ E+ EK + ++
Sbjct: 323 EMMWEKEEKMRRQEEMMWEKEEKIR-------ELEEKMHEQEKIREQEEKRQEEEKIREQ 375
Query: 393 QCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSK 452
+ ++ +A + +Q E+I EQ K +E+ E Q K E+ K
Sbjct: 376 E---------KRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQE-------EK 419
Query: 453 NWSEDD 458
W +++
Sbjct: 420 MWEQEE 425
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 68.2 bits (165), Expect = 2e-11
Identities = 50/225 (22%), Positives = 109/225 (48%), Gaps = 16/225 (7%)
Query: 218 WYNFDSWREFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCD 277
W + R + E++EK ++E W EK+ + + K E +IR
Sbjct: 406 WEKEEKMRRQEEMMWEKEEKMRRQEEMMW-EKEEKIRELEEKMHEQEKIRE--------- 455
Query: 278 PRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALL 337
+ +K +EEEK + E EK+ + EAK QE K ++++ ++ ++EE++ +Q +
Sbjct: 456 -QEEKRQEEEKIR-EQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKI 513
Query: 338 AKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNE 397
++EK +++ + ++ +K+R + W + K+ ++ EK+ + E + E
Sbjct: 514 REEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEE--KMHDQEE 571
Query: 398 TLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
+ ++V + E++I E E+IR+++E+ + + EK
Sbjct: 572 KIREQEEKVWRQ--EEKIREQEEKIREQEEKIREQEEMTQEQEEK 614
Score = 58.2 bits (139), Expect = 2e-08
Identities = 51/241 (21%), Positives = 118/241 (48%), Gaps = 27/241 (11%)
Query: 224 WREFSYLDEEEKEKAECRDERRWIEKQN-------RATRAQRKKEEMNRIRTLVDNAYSC 276
WR+ + E+E EK ++E+ W +++ R ++++EEM R +
Sbjct: 480 WRQEEKIREQE-EKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEI 538
Query: 277 DPRIKKFKE-EEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQA 335
+ +K E EEK +K+ EK + E K +QE K ++++ ++ ++EE++R+Q
Sbjct: 539 WRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQE 598
Query: 336 LLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNE-----------AERVKMMEEVEKLC 384
++++++ ++ +K ++ C+ + E + K+ E+ EK+
Sbjct: 599 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 658
Query: 385 DRLELASLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKE---EAEARMRQASKNTE 441
++ E+ +Q E + +E E++++E E++R+++E E E R+RQ + +
Sbjct: 659 EQEEM--MQEQEEKMWE--QEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 714
Query: 442 K 442
+
Sbjct: 715 E 715
Score = 55.1 bits (131), Expect = 2e-07
Identities = 52/242 (21%), Positives = 117/242 (48%), Gaps = 24/242 (9%)
Query: 230 LDEEEKEKAECRDER--RWIEK---QNRATRAQRKK--EEMNRIRTLVDNAYSCDPRIKK 282
L+++++EK ++E+ W EK Q R Q +K E+ ++R + + + ++++
Sbjct: 355 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 414
Query: 283 FKE---EEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAK 339
+E E++ K +++ E + K +E +EK + E + K +EEE++R+Q +
Sbjct: 415 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 474
Query: 340 KEKDI--QKKAIKKERQKLRNSC-KTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLN 396
+E + Q++ I+++ +K+R K W + E++ E++ + R E +
Sbjct: 475 QEAKMWRQEEKIREQEEKIREQEEKMWR-----QEEKIHEQEKIREEEKRQEQEEMWRQE 529
Query: 397 ETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSE 456
E + + + +Q E+I+EQ K +++ E RQ K ++ K W +
Sbjct: 530 EKIRE------QEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQ 583
Query: 457 DD 458
++
Sbjct: 584 EE 585
Score = 43.5 bits (101), Expect = 6e-04
Identities = 24/93 (25%), Positives = 48/93 (51%), Gaps = 3/93 (3%)
Query: 231 DEEEK---EKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEE 287
++EEK ++ + R++ + I +Q R Q + + + C+ K ++EE
Sbjct: 631 EQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 690
Query: 288 KAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAA 320
K +++ EK + E + ++QE K ++ Q LEAA
Sbjct: 691 KMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAA 723
Score = 42.7 bits (99), Expect = 0.001
Identities = 27/108 (25%), Positives = 60/108 (55%), Gaps = 5/108 (4%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQRK-KEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKE 292
E+E+ C E + E++ + R + K +E+ +IR + + ++ ++EEK ++
Sbjct: 617 EQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ--EQEEKMWEQ 674
Query: 293 AEKKAKAEAKRKEQEAKEKQRQAEL--EAARLAKEKEEEEVRQQALLA 338
EK + E K +EQE K ++++ ++ + RL +++E+ + Q+ L A
Sbjct: 675 EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722
Score = 41.2 bits (95), Expect = 0.003
Identities = 54/241 (22%), Positives = 108/241 (44%), Gaps = 25/241 (10%)
Query: 231 DEEEKEK-AECRDERRWIEKQNRATRAQRK--KEEMNRIRTLVDNAYSCDPRIKKFKEEE 287
DEE KEK A+ +++ + +E + + K K ++ R + L+ P+ + E +
Sbjct: 277 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLL-------PQQQLQAEAD 329
Query: 288 KAKKEAEK-KAKAEAKRKEQEAKEKQRQAELEAARLAKEK----EEEEVRQQALLAKKEK 342
KE + AK +A+ +E E + Q + E +EK EE+ Q+ + ++E+
Sbjct: 330 HLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE 389
Query: 343 DIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLEL-----ASLQCLNE 397
I+++ K RQ+ W + M E+ EK+ + E+ ++ L E
Sbjct: 390 KIREQEEKMRRQEE----MMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 445
Query: 398 TLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSED 457
+ K + ++ E+I EQ +++++EA+ RQ K E+ K W ++
Sbjct: 446 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK-MWRQEEKIREQEEKIREQEEKMWRQE 504
Query: 458 D 458
+
Sbjct: 505 E 505
Score = 40.4 bits (93), Expect = 0.005
Identities = 31/159 (19%), Positives = 74/159 (46%), Gaps = 28/159 (17%)
Query: 224 WREFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYS-------- 275
WR+ + ++E EK ++E+ W +++ + ++ +E+ +IR +
Sbjct: 560 WRQEEKMHDQE-EKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQ 618
Query: 276 ----CDPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAEL-------------- 317
C+ K ++EEK +++ EK + E K +EQE K ++++ +
Sbjct: 619 EEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 678
Query: 318 -EAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQK 355
E +E+EE+ RQ+ + ++E ++++ K + +
Sbjct: 679 CEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 717
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 67.4 bits (163), Expect = 4e-11
Identities = 57/220 (25%), Positives = 110/220 (50%), Gaps = 40/220 (18%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKE--EEKA 289
EE +E+ R+E + +E++ R R +R++EE D +K+ +E +++
Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKREQEERR------------DQLLKREEERRQQRL 590
Query: 290 KKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAI 349
K+E E++ + KR+E E E++ + E RL +E+ EEE RQQ L ++++++ +++ +
Sbjct: 591 KREQEERLEQRLKREEVERLEQEERRE---QRLKREEPEEERRQQLLKSEEQEERRQQQL 647
Query: 350 KKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKA 409
++E+Q+ R +R+K EE E+L RL+ + E +E+ +
Sbjct: 648 RREQQERRE-------------QRLKREEEEERLEQRLKREHEEERRE------QELAEE 688
Query: 410 ALEKQIEEINEQIRK----EKEEAEARMRQASKNTEKSTG 445
E+ E I +I K + EA+AR + K G
Sbjct: 689 EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEG 728
Score = 66.2 bits (160), Expect = 8e-11
Identities = 52/217 (23%), Positives = 108/217 (49%), Gaps = 27/217 (12%)
Query: 231 DEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAK 290
+EE +E+ E R+++ E++ R + +++EE R++ ++ + E++ +
Sbjct: 493 EEERREQQERREQQLRREQEERREQRLKRQEEEERLQ-------------QRLRSEQQLR 539
Query: 291 KEAEKKA-----KAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQ 345
+E E++ + E KR EQE +E++ + E E R K EEE RQQ L ++E+ ++
Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE 599
Query: 346 KKAIKKERQKLRNSCKTWNHFSDNEAER------VKMMEEVEKLCDRLELASLQCLNETL 399
++ ++E ++L + E E +K E+ E+ +L + + L
Sbjct: 600 QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRL 659
Query: 400 TSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQA 436
+E + LE++++ +E+ R+E+E AE QA
Sbjct: 660 ---KREEEEERLEQRLKREHEEERREQELAEEEQEQA 693
Score = 62.0 bits (149), Expect = 2e-09
Identities = 44/219 (20%), Positives = 112/219 (51%), Gaps = 9/219 (4%)
Query: 231 DEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLV-------DNAYSCDPRIKKF 283
+EE +E+ R+++ E+Q R + R+++++ R + L + + ++++
Sbjct: 369 EEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 428
Query: 284 KEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKD 343
+EEE+ +++ E++ + + ++EQE + + E E R +E+ ++++++ ++E+
Sbjct: 429 QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488
Query: 344 IQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCT 403
++ + ++ Q+ R + + +R+K EE E+L RL S Q L
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR--SEQQLRREQEERR 546
Query: 404 KEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
+++ K EK++E+ + R ++E+ E R + + E+
Sbjct: 547 EQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEER 585
Score = 57.4 bits (137), Expect = 4e-08
Identities = 51/232 (21%), Positives = 106/232 (45%), Gaps = 31/232 (13%)
Query: 218 WYNFDSWREFSYLDEEEKEKAECR--------DERRWIEKQNRATRAQRKKEEMNRIRTL 269
W W+E EE++ C+ DE + ++ R + ++E+ + R
Sbjct: 174 WRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRER 233
Query: 270 VDNAYSCDPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEE 329
D + + + K E +KE EK + E +R+ + +E+++ +LE L +E++EE
Sbjct: 234 QDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEE 293
Query: 330 EVRQQALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLEL 389
E +QQ L ++E+ +++K ++ R++ + ER + E E+ +R E
Sbjct: 294 EQQQQRL--RREQQLRRKQEEERREQ--------------QEERREQQERREQQEERREQ 337
Query: 390 ASLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTE 441
+ E + + E++ E +Q+R+E+EE E R +Q + +
Sbjct: 338 QLRREQEE------RREQQLRREQEEERREQQLRREQEE-ERREQQLRREQQ 382
Score = 55.1 bits (131), Expect = 2e-07
Identities = 50/240 (20%), Positives = 117/240 (48%), Gaps = 34/240 (14%)
Query: 225 REFSYLDEEE----KEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRI 280
+E L EEE +E E ++ R +E+Q Q ++++ R+R + ++
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRR--------EQQL 306
Query: 281 KKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAAR---LAKEKEEE-------- 329
++ +EEE+ +++ E++ + E + +++E +E+Q + E E R L +E+EEE
Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRR 366
Query: 330 ---EVRQQALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDR 386
E R++ L ++++ +++ +++E+Q R + + R + + ++L
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQ----QLRREQQLRREQQLRREQQLRRE 422
Query: 387 LELASLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKE----EAEARMRQASKNTEK 442
+L Q +E + L+++ EE + +++E+E E E R +Q ++ E+
Sbjct: 423 QQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEE 482
Score = 54.3 bits (129), Expect = 3e-07
Identities = 49/220 (22%), Positives = 114/220 (51%), Gaps = 18/220 (8%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK 284
RE ++E+E+ E ++ERR +++ R + +R+++++ R + + ++++ +
Sbjct: 302 REQQLRRKQEEERREQQEERRE-QQERREQQEERREQQLRR-----EQEERREQQLRREQ 355
Query: 285 EEEKAKKEAEKKAKAEAKRKEQE-AKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKD 343
EEE+ +E + + + E +R+EQ+ +E+Q + E + R + + E+++R++ L ++E+
Sbjct: 356 EEER--REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQL-RREQQ 412
Query: 344 IQKKAIKKERQKLRNSCKTWNHFSDNEAER--VKMMEEVEKLCDRLELASLQCLNETLTS 401
++++ + Q+LR + H +E ER ++ E E+ D L+ E
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK------REEETER 466
Query: 402 CTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTE 441
+E K L++ EE + + EE E R +Q + +
Sbjct: 467 HEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQ 506
Score = 53.5 bits (127), Expect = 6e-07
Identities = 58/246 (23%), Positives = 121/246 (49%), Gaps = 23/246 (9%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQRKKE---EMNRIRTLVDNAYSCDPRIKKFKEEEK-- 288
E+E R+++E++ R R +R+++ E ++R R +KF+EEE+
Sbjct: 1364 EEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQL 1423
Query: 289 AKKEAEKKAKAE---AKRKEQEAKEKQRQAELEAARLAKEKEEEEV---RQQALLAKKEK 342
+++E ++K + E +R+E+E K + + +L R K +EEE++ R++ L ++E+
Sbjct: 1424 SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER 1483
Query: 343 DIQKKAIKKE---RQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETL 399
D +K +++E R++ R+ E ER K +EE ++L + + L E
Sbjct: 1484 D--RKFLEEEQQLRRQERDRKFREQELRSQEPER-KFLEEEQQL--HRQQRQRKFLQEEQ 1538
Query: 400 TSCTKEVGKAALEKQIEEI--NEQIRKEKEEAEARMRQASK--NTEKSTGGGGNGSKNWS 455
+E G+ + + + EQ+R+E+EE + ++ + E+ + +
Sbjct: 1539 QLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFM 1598
Query: 456 EDDLQL 461
ED+ QL
Sbjct: 1599 EDEQQL 1604
Score = 52.8 bits (125), Expect = 1e-06
Identities = 47/215 (21%), Positives = 100/215 (46%), Gaps = 10/215 (4%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQR--KKEEMNRIRTLVDNAYSCDPRIKKFKEEEKA 289
EEE E+ E ++ +++ R +R K EE R R + R ++ + E++
Sbjct: 461 EEETERHEQERRKQQLKRDQEEERRERWLKLEEEER-REQQERREQQLRREQEERREQRL 519
Query: 290 KKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAI 349
K++ E++ + R EQ+ + +Q + + + +EK E+ R++ L +++++ + + +
Sbjct: 520 KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579
Query: 350 KKERQKLRNSCK------TWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCT 403
K+E ++ + K E ER++ E E+ R E + +
Sbjct: 580 KREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQ 639
Query: 404 KEVGKAALEKQIEEINEQIRKEKEEAEARMRQASK 438
+E + L ++ +E EQ R ++EE E R+ Q K
Sbjct: 640 EERRQQQLRREQQERREQ-RLKREEEEERLEQRLK 673
Score = 52.0 bits (123), Expect = 2e-06
Identities = 43/205 (20%), Positives = 94/205 (45%), Gaps = 25/205 (12%)
Query: 236 EKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEK 295
E ++ RD + + Q+ Q + E R R R + F EEE+ ++E +K
Sbjct: 1254 EDSQLRDRQSQQDLQHLLGEQQERDREQERRRW--------QQRDRHFPEEEQLEREEQK 1305
Query: 296 KAKAEAKRKEQEAK-------EKQRQAEL-----EAARLAKEKEEEEVRQQALLAKKEKD 343
+AK ++ ++E + EK+R+ E E +L +E+EE+ +R+Q ++++
Sbjct: 1306 EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ----ERDRK 1361
Query: 344 IQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCT 403
+++ ++ + Q R + E ER + EE + C E Q +
Sbjct: 1362 FREEELRHQEQG-RKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEE 1420
Query: 404 KEVGKAALEKQIEEINEQIRKEKEE 428
+++ + +++ E +Q+R+++ E
Sbjct: 1421 QQLSRQERDRKFREEEQQVRRQERE 1445
Score = 51.2 bits (121), Expect = 3e-06
Identities = 50/221 (22%), Positives = 102/221 (46%), Gaps = 19/221 (8%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEKQNRAT--RAQRKKEEMNRIRTLVDNAYSCDPRIKK 282
RE Y +EEE ++ E + R EK+ R R RKK+E+ + ++
Sbjct: 986 REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEE-------------EQ 1032
Query: 283 FKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEK 342
EE+ K+ +++ + + +E + +E+Q E R +E E + +++ L ++E+
Sbjct: 1033 LLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQ 1092
Query: 343 DIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSC 402
++++ K+ RQ+ C+ E + ++ EE EK R EL E +
Sbjct: 1093 LLREEPEKRRRQERERQCREEEELQQEEEQLLR--EEREKR-RRQELERQYREEEEVQQE 1149
Query: 403 TKEVGKAALEK-QIEEINEQIRKEKEEAEARMRQASKNTEK 442
+++ + EK + +E+ Q R+E+E + + + EK
Sbjct: 1150 EEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEK 1190
Score = 50.8 bits (120), Expect = 4e-06
Identities = 54/263 (20%), Positives = 119/263 (45%), Gaps = 53/263 (20%)
Query: 225 REFSYLDEEEKEKAECRD-------------ERRWIEKQNRATRAQRKK---EEMNRIRT 268
R+ +L+EE++ + + RD ER+++E++ + R QR++ +E ++R
Sbjct: 1483 RDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRR 1542
Query: 269 LVDNAYSCDPRIKKFKEEEKAKKEAE------------------KKAKAEAKRK----EQ 306
R +KF+EEE+ ++E E K + E +RK EQ
Sbjct: 1543 QERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQ 1602
Query: 307 EAKEKQRQAELEAARLAKEKEEEEV---RQQALLAKKEKD-------IQKKAIKKERQKL 356
+ + ++ Q +L R K +E+E++ R++ L ++E+D Q + ++E+Q
Sbjct: 1603 QLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLR 1662
Query: 357 RNSCKTWNH----FSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAALE 412
+ + + + E ++++ E K + + Q +++ + LE
Sbjct: 1663 HDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELE 1722
Query: 413 KQIEEINEQIRKEKEEAEARMRQ 435
++ E EQ+R+E E+ + R ++
Sbjct: 1723 RKFRE-EEQLRQETEQEQLRRQE 1744
Score = 50.4 bits (119), Expect = 5e-06
Identities = 49/220 (22%), Positives = 98/220 (44%), Gaps = 25/220 (11%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK 284
+E L EEE+E E+R ++Q R R + + ++ ++
Sbjct: 901 KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEE----------------EQLL 944
Query: 285 EEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDI 344
EE+ K+ +++ + K K+ + KE+Q E R +E+E++ ++ L ++E+ +
Sbjct: 945 REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLL 1004
Query: 345 QKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDR----LELASLQCLNETLT 400
+++ K+ RQ+ + + E + ++ E +L +R E LQ E L
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLL 1064
Query: 401 SCTKEV-GKAALEKQIEEINEQIRKE----KEEAEARMRQ 435
+E + LE+Q + E ++E +EE E R RQ
Sbjct: 1065 GEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQ 1104
Score = 48.9 bits (115), Expect = 1e-05
Identities = 57/235 (24%), Positives = 108/235 (45%), Gaps = 40/235 (17%)
Query: 232 EEEKEKAEC--------RDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPR-IKK 282
EE+ EK E RDE W ++Q R +R+ EE + SC ++
Sbjct: 152 EEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEE--------EQLQSCKGHETEE 203
Query: 283 FKEEEKAKK----EAEKKAKAEA--KRKE------QEAKEKQRQAELEAARLAKEK-EEE 329
F +EE+ ++ E +K + E +R+E QE +EK+ + R +EK +EE
Sbjct: 204 FPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEE 263
Query: 330 EVRQQALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLC--DRL 387
E ++Q L ++E+ ++ K ERQ+LR + + +R++ +++ + +R
Sbjct: 264 EPQRQRELQEEEEQLR----KLERQELRRE----RQEEEQQQQRLRREQQLRRKQEEERR 315
Query: 388 ELASLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
E + + +E + L ++ EE EQ + ++E E R +Q + E+
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE 370
Score = 48.5 bits (114), Expect = 2e-05
Identities = 59/253 (23%), Positives = 120/253 (47%), Gaps = 37/253 (14%)
Query: 224 WREFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKF 283
+RE L +E +E+ R ER +++ R Q +++E R + +KF
Sbjct: 1669 FREEEQLLQEGEEQQLRRQER---DRKFREEEQQLRRQERERKFLQEEQQLRRQELERKF 1725
Query: 284 KEEEKAKKEAE--------------KKAKAEAKRKEQEAKEKQRQAEL-EAARLAKEKEE 328
+EEE+ ++E E ++ + +R+EQ+ + ++R + E +L +E+EE
Sbjct: 1726 REEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREE 1785
Query: 329 EEVRQQALLAKKEKDIQKKAIKKERQ---KLRNSCKTWNHFSDNEAERVKMMEEVEKL-- 383
+++R Q K ++ Q + ++E+Q + R+ W E E++++ E+ ++L
Sbjct: 1786 QQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRW------EEEQLQLEEQEQRLRQ 1839
Query: 384 -CDRLELASLQ-CLNETLTSCTKEVGKAALEKQIEEINEQIRKE----KEEAEARMRQAS 437
DR A Q E +E+ + +K+ +E ++R+E +++ E R RQ
Sbjct: 1840 ERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVG 1899
Query: 438 KNTEKSTGGGGNG 450
+ KS G G+G
Sbjct: 1900 E--IKSQEGKGHG 1910
Score = 48.1 bits (113), Expect = 2e-05
Identities = 53/243 (21%), Positives = 108/243 (44%), Gaps = 20/243 (8%)
Query: 226 EFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKE 285
E L+ EE+++A+ RD + EKQ R++ E R R D + + ++ + +E
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEEKQ-----LLREEREEKRRRQETDRKFREEEQLLQERE 1349
Query: 286 EEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKE----KEEEEVRQQALLAKKE 341
E+ +++ + E + + QE K + E R +E KEE+++R Q +
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLR 1409
Query: 342 KDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTS 401
+D +K ++E+Q R + F + E ++V+ E K L Q L +
Sbjct: 1410 QDRDRKFREEEQQLSRQ--ERDRKFREEE-QQVRRQERERKF-----LEEEQQLRQERHR 1461
Query: 402 CTKEVGKAALEKQIEEINEQIRKEK---EEAEARMRQASKNTEKSTGGGGNGSKNWSEDD 458
+E + E++ ++++ Q R K EE + R ++ + + + + E++
Sbjct: 1462 KFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEE 1521
Query: 459 LQL 461
QL
Sbjct: 1522 QQL 1524
Score = 46.6 bits (109), Expect = 7e-05
Identities = 50/218 (22%), Positives = 102/218 (46%), Gaps = 30/218 (13%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK 284
R L EE+E+ + RR E+Q R + +++EE R+ + + + R ++
Sbjct: 629 RRQQLLKSEEQEERRQQQLRR--EQQERREQRLKREEEEERLEQRLKREHEEERREQELA 686
Query: 285 EEEKAKKEAEKKAK-------AEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALL 337
EEE+ + K++ E++ +++K R + E R +E+EE+ R+++ L
Sbjct: 687 EEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL 746
Query: 338 AKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNE 397
+E +++A ++++++ + TW ++ ++ER R L++ L E
Sbjct: 747 QWQE---EERAHRQQQEEEQRRDFTWQWQAEEKSER-----------GRQRLSARPPLRE 792
Query: 398 TLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQ 435
+E A E+Q E ++ E+EE E R RQ
Sbjct: 793 -----QRERQLRAEERQQRE--QRFLPEEEEKEQRRRQ 823
Score = 45.4 bits (106), Expect = 2e-04
Identities = 52/242 (21%), Positives = 110/242 (45%), Gaps = 36/242 (14%)
Query: 225 REFSYLDEEE--KEKAECRDERRWIEKQNRATRAQRKKEEMNRI-----------RTLVD 271
RE Y +EEE +E+ + E R ++ R RK+EE+ + R +
Sbjct: 1046 RERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE 1105
Query: 272 NAYSCDPRIKKFKEEEKA-KKEAEKKAKAEAKRKEQEAKEKQRQAEL----EAARLAKEK 326
C + +EEE+ ++E EK+ + E +R+ +E +E Q++ E E + +++
Sbjct: 1106 RERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQE 1165
Query: 327 EEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDR 386
E + R++ L ++E+ + ++ +K RQ+ + E E ++ + ++ D
Sbjct: 1166 LERQYREEEELQQEEEQLLREEQEKRRQERERQYR--------EEEELQRQKRKQRYRDE 1217
Query: 387 LELASLQCLNETLTSCTKEVGKAALEKQI---EEINEQIRKEKEEAEARMRQASKNTEKS 443
+ + L+ E E A + ++ NEQ R + E+++ R RQ+ ++ +
Sbjct: 1218 DQRSDLKWQWE------PEKENAVRDNKVYCKGRENEQFR-QLEDSQLRDRQSQQDLQHL 1270
Query: 444 TG 445
G
Sbjct: 1271 LG 1272
Score = 45.4 bits (106), Expect = 2e-04
Identities = 47/222 (21%), Positives = 105/222 (47%), Gaps = 15/222 (6%)
Query: 224 WREFSYLDEEEKEKAECRDER--RWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIK 281
+RE L +E +E+ R ER +++E++ + R +R ++ + S +P +
Sbjct: 1463 FREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQ------ELRSQEPE-R 1515
Query: 282 KFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKE 341
KF EEE+ +++ K ++EQ+ + ++R + R K +EEE++RQ+ +
Sbjct: 1516 KFLEEEQQLHRQQRQRK--FLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS 1573
Query: 342 KDIQKKAIKKERQKLRNSCKTWNHFSD-NEAERVKMMEEVEKLCDRLELASLQCLNETLT 400
+ + + + E QK+R + D + R + +++ + DR Q L E
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQERE- 1632
Query: 401 SCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
+++ + +++ E Q+R+++ E + R + K E+
Sbjct: 1633 --EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREE 1672
Score = 45.4 bits (106), Expect = 2e-04
Identities = 60/251 (23%), Positives = 105/251 (41%), Gaps = 75/251 (29%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK 284
R+ +L+EE + + R ER E+Q R R ++ +EE ++ + R +KF+
Sbjct: 1641 RDRKFLEEEPQLR---RQER---EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFR 1694
Query: 285 EEEKAKKEAEKKAK-----AEAKRKEQEAK---EKQRQAELEAARLAKEK------EEEE 330
EEE+ + E++ K + +R+E E K E+Q + E E +L +++ EEE+
Sbjct: 1695 EEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQ 1754
Query: 331 VRQQALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELA 390
+R + +E Q+LR ER + E E+L E
Sbjct: 1755 LRPE----------------REEQQLRRQ------------ERDRKFREEEQLRQEREEQ 1786
Query: 391 SLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNG 450
L+ +++ E EQ+R+E+EE + R +Q +G
Sbjct: 1787 QLRSQES--------------DRKFRE-EEQLRQEREEQQLRPQQR------------DG 1819
Query: 451 SKNWSEDDLQL 461
W E+ LQL
Sbjct: 1820 KYRWEEEQLQL 1830
Score = 43.9 bits (102), Expect = 4e-04
Identities = 39/182 (21%), Positives = 84/182 (46%), Gaps = 20/182 (10%)
Query: 286 EEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQ 345
+++ ++E +++ + ++ E+E +++RQ E R E EE+ +Q+ L +++D Q
Sbjct: 111 QDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERL---EQRDRQ 167
Query: 346 KKAIKKERQKLRNSCKTWNHFSDNEAERVKMM----EEVEKLCDRLELASLQCLNETLTS 401
++ + RQ+ + W + AE ++ E E+ D +L + L
Sbjct: 168 RRDEELWRQR-----QEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLE----- 217
Query: 402 CTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQA--SKNTEKSTGGGGNGSKNWSEDDL 459
+ G+ ++Q E +++ +E+EE E R R+ K EK + E++
Sbjct: 218 -LRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEE 276
Query: 460 QL 461
QL
Sbjct: 277 QL 278
Score = 42.7 bits (99), Expect = 0.001
Identities = 40/219 (18%), Positives = 96/219 (43%), Gaps = 12/219 (5%)
Query: 235 KEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAE 294
+ +A+ R + + + + + +R+++E R R + + + R + ++EE+ +++
Sbjct: 709 ESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFT 768
Query: 295 KKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQ 354
+ +AE K + + R E EE + R+Q L ++E+ Q++ ++ER+
Sbjct: 769 WQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE 828
Query: 355 KLRNSCKTWNHFSDNEAERVKMMEEVEKLCD-----------RLELASLQCLNETLTSCT 403
K + E + ++ EE + L + R + Q E
Sbjct: 829 KELQFLEEEEQLQRRERAQ-QLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRH 887
Query: 404 KEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
K AL++Q+ + + +++E+EE + R+ + E+
Sbjct: 888 TLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQ 926
Score = 42.4 bits (98), Expect = 0.001
Identities = 46/226 (20%), Positives = 106/226 (46%), Gaps = 20/226 (8%)
Query: 230 LDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKA 289
L EEE E ++ RR E++ + +EE R R + + +++K ++ +
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908
Query: 290 KKEAEKKAKAEAKRKEQEAKE--KQRQAELEAARLAKEKEEEEVRQQ-ALLAKKEKDIQK 346
++E ++ + E +R++++ ++ ++ Q + E +L +E+ E+ RQ+ +K+K +Q+
Sbjct: 909 EEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQ 968
Query: 347 K-----AIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTS 401
K + E+++ + K + + + E +++ E + R E + L
Sbjct: 969 KEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQ 1028
Query: 402 CTKEVGKAALEK-QIEEINEQIRKEK-----------EEAEARMRQ 435
+++ + EK +++E Q R+E+ EE E R RQ
Sbjct: 1029 EEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQ 1074
Score = 41.6 bits (96), Expect = 0.002
Identities = 54/251 (21%), Positives = 110/251 (43%), Gaps = 45/251 (17%)
Query: 230 LDEEEKEKAECRD----ERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKE 285
LDEE++ + + ++ +RR E Q R R+ EE R R ++ +E
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRR-------QKRQEQERE 147
Query: 286 EEKAKKEAEKKAKAEAK----------RKEQEAKEK-QRQAELEAARLAKEKEEEEVRQQ 334
+ ++++EK+ + E + R+ QE +E+ +R+AE E + K E EE +
Sbjct: 148 LAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDE 207
Query: 335 ALLAKKE-KDIQKKAIKKERQKLR---------NSCKTW-----------NHFSDNEAER 373
L ++E ++++K ++++Q+ R K W + E +R
Sbjct: 208 EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR 267
Query: 374 VKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGK--AALEKQIEEINEQIRKEKEEAEA 431
+ ++E E+ +LE L+ + + + + KQ EE EQ + +E+ E
Sbjct: 268 QRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER 327
Query: 432 RMRQASKNTEK 442
R +Q + ++
Sbjct: 328 REQQEERREQQ 338
Score = 40.8 bits (94), Expect = 0.004
Identities = 42/228 (18%), Positives = 102/228 (44%), Gaps = 5/228 (2%)
Query: 224 WREFSYLDEEEKEKAECRDER-RWI--EKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRI 280
W+E +++E+ + RD +W EK R + + + R A R
Sbjct: 748 WQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQRE 807
Query: 281 KKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKK 340
++F EE+ K++ ++ + K + +E+Q Q A +L +E++ + Q+ +++
Sbjct: 808 QRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQE 867
Query: 341 EKDIQK--KAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNET 398
++ QK +++ER++ R++ + + ++++E E+ R E + +
Sbjct: 868 QRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE 927
Query: 399 LTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGG 446
+E + E+ + E E+ R+++ E + R + + E+ G
Sbjct: 928 RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 66.6 bits (161), Expect = 6e-11
Identities = 56/231 (24%), Positives = 109/231 (47%), Gaps = 25/231 (10%)
Query: 218 WYNFDSWREFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCD 277
W + R + E++EK +E W EK+ + + K E +IR
Sbjct: 345 WEKEEKMRRQEEMMWEKEEKMRRLEEMMW-EKEEKIRELEEKMHEQEKIRE--------- 394
Query: 278 PRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALL 337
+ +K +EEEK + E EK+ + EAK QE K ++++ ++ ++EE++ +Q +
Sbjct: 395 -QEEKRQEEEKIR-EQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKI 452
Query: 338 AKKEKDIQKKAIKKERQKLRNSCKTWNHFSD-NEAERVKMMEE-----VEKLCDRLELAS 391
++EK +++ + ++ +K+R + W +E E+++ EE EK+ D+ E
Sbjct: 453 REEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEK-- 510
Query: 392 LQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
+ E ++ K + +Q E+I EQ K +E+ E Q K E+
Sbjct: 511 ---IREQEEKMWRQEEK--IREQEEKIREQEEKIREQEEMMQEQEEKMGEQ 556
Score = 66.6 bits (161), Expect = 6e-11
Identities = 54/238 (22%), Positives = 114/238 (47%), Gaps = 37/238 (15%)
Query: 224 WREFSYLDEEEK---EKAECRDERRW-----IEKQNRATRAQRKKEEMNRIRTLVDNAYS 275
WR+ + E+EK E+ E W I +Q R + K E +IR + +
Sbjct: 440 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWR 499
Query: 276 CDPRI-----KKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEE 330
+ ++ K ++EEK ++ EK + E K +EQE K ++++ ++ ++EE+
Sbjct: 500 QEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEK 559
Query: 331 VRQQALLAKKEKDI--QKKAIKKERQKLR-NSCKTWNHFSDNEAERVKMMEEVEKLCDRL 387
+++Q + ++E+ I Q++ I+++++K+R K W + M E+ EK+ ++
Sbjct: 560 MQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQE 619
Query: 388 ELASLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKE---EAEARMRQASKNTEK 442
E Q E++++E E++R+++E E E R+RQ + ++
Sbjct: 620 EKMCEQ------------------EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 659
Score = 47.8 bits (112), Expect = 3e-05
Identities = 49/220 (22%), Positives = 98/220 (44%), Gaps = 35/220 (15%)
Query: 230 LDEEEKEKAECRDER--RWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEE 287
L+++++EK ++E+ W EK R++EE R ++EE
Sbjct: 294 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR------------------EQEE 335
Query: 288 KAKKEAEKKAKAEAKRKEQEA-----KEKQRQAE---LEAARLAKEKEEEEVRQQALLAK 339
K +++ E + E K + QE +EK R+ E E +E EE+ Q+ + +
Sbjct: 336 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQ 395
Query: 340 KEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETL 399
+EK +++ I+++ ++ K W + K+ E+ +K+ + E Q E +
Sbjct: 396 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ---EKI 452
Query: 400 TSCTKEVGKAALEKQIEEINEQ----IRKEKEEAEARMRQ 435
K + + +Q E+I EQ +KEK + ++R+
Sbjct: 453 REEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRK 492
Score = 44.7 bits (104), Expect = 3e-04
Identities = 25/88 (28%), Positives = 45/88 (51%), Gaps = 2/88 (2%)
Query: 233 EEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKE 292
E+KEK ++E+ W +Q R Q + + + C+ K ++EEK +++
Sbjct: 582 EQKEKIREQEEKIW--EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 639
Query: 293 AEKKAKAEAKRKEQEAKEKQRQAELEAA 320
EK + E + ++QE K ++ Q LEAA
Sbjct: 640 EEKMWEQEVRLRQQEEKMQEHQEHLEAA 667
Score = 41.6 bits (96), Expect = 0.002
Identities = 85/415 (20%), Positives = 171/415 (41%), Gaps = 62/415 (14%)
Query: 231 DEEEKEK-AECRDERRWIEKQNRATRAQRK--KEEMNRIRTLVDNAYSCDPRIKKFKEEE 287
DEE KEK A+ +++ + +E + + K K ++ R + L+ P+ + E +
Sbjct: 216 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLL-------PQQQLQAEAD 268
Query: 288 KAKKEAEK-KAKAEAKRKEQEAKEKQRQAELEAARLAKEK----EEEEVRQQALLAKKEK 342
KE + AK +A+ +E E + Q + E +EK EE+ Q+ + ++E+
Sbjct: 269 HLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE 328
Query: 343 DIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSC 402
I+++ K RQ+ W + + +MM E E+ RLE +
Sbjct: 329 KIREQEEKMRRQEE----MMWEK-EEKMRRQEEMMWEKEEKMRRLEEMMWE--------- 374
Query: 403 TKEVGKAALEKQIEEINEQIR--KEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQ 460
KE LE+++ E E+IR +EK + E ++R+ K E+ +K W ++ +
Sbjct: 375 -KEEKIRELEEKMHE-QEKIREQEEKRQEEEKIREQEKRQEQE-------AKMWRQE--E 423
Query: 461 LLIKAVNLFPAGTNSRWEVIANYMNIHSSSGVKRTAK-----------DVIGKAKSL--Q 507
+ + W IH ++ K + I + + + Q
Sbjct: 424 KIREQEEKIREQEKKMWR---QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQ 480
Query: 508 KLDPHQKDDINKKAFDKFKKEHGVVPQADNATPSERFEGPYTDFTPWTTEEQKLLEQ--A 565
K H+++ I K+ +++E + Q + E E + +E+K+ EQ
Sbjct: 481 KEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQE--EKMWRQEEKIREQEEKIREQEEK 538
Query: 566 LKTYPVNTPERWEKIAEAVPGRTKKDCMKRYKELVEMVKAKKAAQEQVLNASRAK 620
++ E+ EK+ E +++ M+R +E + + K Q++ + K
Sbjct: 539 IREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEK 593
Score = 40.8 bits (94), Expect = 0.004
Identities = 31/143 (21%), Positives = 74/143 (51%), Gaps = 11/143 (7%)
Query: 224 WREFSYLDEEEK----EKAECRDERRWIEKQNRATRAQRKK-EEMNRIRTLVDNAYSCDP 278
WR+ + E+E+ ++ + R++ +++Q Q +K +E ++R + +
Sbjct: 519 WRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEE 578
Query: 279 RIKKFKE-----EEKAKKEAEKKAKAEAKRKEQEAKEKQRQAEL-EAARLAKEKEEEEVR 332
+I++ KE EEK ++ EK + E +EQE K +++ ++ E +E+EE+ R
Sbjct: 579 KIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR 638
Query: 333 QQALLAKKEKDIQKKAIKKERQK 355
Q+ + ++E ++++ K + +
Sbjct: 639 QEEKMWEQEVRLRQQEEKMQEHQ 661
Score = 40.4 bits (93), Expect = 0.005
Identities = 33/150 (22%), Positives = 68/150 (45%), Gaps = 26/150 (17%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEA 293
E+E+ E + E++ + ++ + + +IR ++EEK +++
Sbjct: 541 EQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIR----------------EQEEKIREQK 584
Query: 294 EKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKER 353
EK + E K EQE K ++++ + +E+EE+ Q+ + ++E+ +Q++ K R
Sbjct: 585 EKIREQEEKIWEQEEKIREQE------EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR 638
Query: 354 QKLRNSCKTWNHFSDNEAERVKMMEEVEKL 383
Q+ K W + KM E E L
Sbjct: 639 QEE----KMWEQEVRLRQQEEKMQEHQEHL 664
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 65.9 bits (159), Expect = 1e-10
Identities = 52/220 (23%), Positives = 105/220 (47%), Gaps = 10/220 (4%)
Query: 232 EEEKEKAECRDERRWIEKQN----RATRAQRKKEEMNRIRTLVDNAYSCD-PRIKKFKEE 286
E EK + E R+ R EK+N R + R++E T + D R ++ K E
Sbjct: 180 EREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTE 239
Query: 287 EKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQK 346
+ +K+AE++ +E + + + +E++R + + R KE+E + R++ +++++ ++
Sbjct: 240 REREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETER 299
Query: 347 KAIK---KERQKLRNSCKTWNHFSDNEAERVKMME-EVEKLCDRLELASLQCLNETLTSC 402
K + +ER++ RN + + E ER + E + EK +R + E
Sbjct: 300 KRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQT 359
Query: 403 TKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
+E G+ E++ E E+ R+ E E R R ++ +K
Sbjct: 360 GRE-GRRQAERERERERERDRQSAREREERERDRDRDRQK 398
Score = 54.3 bits (129), Expect = 3e-07
Identities = 52/228 (22%), Positives = 101/228 (44%), Gaps = 25/228 (10%)
Query: 232 EEEKEKAECRDERRWIEK--QNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKA 289
E+E+E+ R+ +R E+ Q R + ++E R R + D ++ +E E+
Sbjct: 156 EKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERE 215
Query: 290 KK---EAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQK 346
++ E E+K + + +R Q E++R+ + E R A E+E E +++ +++D +
Sbjct: 216 RETETETERKRQTDRERDRQRKTEREREKQAERER-ASERETERDKERERERDRDRDRDR 274
Query: 347 KAIKKERQKLRNSCKTWNHFSDNEAERVKMME-EVEKLCDRLELASLQCLNETLTSCTKE 405
+ ++ERQ R + + E +R + E E E+ +R K
Sbjct: 275 RQKERERQTDRKRQRRTERDRETERKRERQRERERERERNR-----------------KR 317
Query: 406 VGKAALEKQIEEINEQIR-KEKEEAEARMRQASKNTEKSTGGGGNGSK 452
+ E++ E E R +EKE R RQ + E++ G G +
Sbjct: 318 ERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRR 365
Score = 52.0 bits (123), Expect = 2e-06
Identities = 54/236 (22%), Positives = 107/236 (45%), Gaps = 45/236 (19%)
Query: 223 SWREFSYLDEEEKEKAECRD-ERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIK 281
S RE E E+E+ RD +RR E++ + R ++++ E +R +
Sbjct: 252 SERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDR------------ETER 299
Query: 282 KFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKE 341
K + + + ++E E+ K E +R+ + +E+QR+ E + +EKE E R++ +E
Sbjct: 300 KRERQRERERERERNRKRERERERERERERQRETERD-----REKERERKRKRQTEMDRE 354
Query: 342 KDIQ-----KKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLN 396
++ Q ++ ++ER++ R + + + + EE E+ DR Q
Sbjct: 355 RNRQTGREGRRQAERERERER----------ERDRQSAREREERERDRDR----DRQKER 400
Query: 397 ETLTSCTKEVGKAALEKQIE-------EINEQIRKEKEEAEARMRQASKNTEKSTG 445
E T ++ G+ EKQ E E + +E+E+ + R R + T++ G
Sbjct: 401 ERQTEKDRD-GQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAG 455
Score = 50.1 bits (118), Expect = 6e-06
Identities = 42/219 (19%), Positives = 102/219 (46%), Gaps = 16/219 (7%)
Query: 231 DEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAK 290
+ +++ E R E+R E++ R +R++++ +R R D ++ ++ EK +
Sbjct: 55 ERNRQKERERRREKRQTERETDRKRERRREKDRHRKR---------DRHRERQRDREKER 105
Query: 291 -KEAEKKAKAEAKRKEQEAKEKQRQAELEAAR-LAKEKEEEEVRQQALLAKKEKDIQ--- 345
++ +++ + +++ KE++R+ E E R ++ + + R++ A+KE++ Q
Sbjct: 106 ERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDR 165
Query: 346 --KKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCT 403
++ ++ RQK R K + E +R K + ++ +R + ET T
Sbjct: 166 ERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERK 225
Query: 404 KEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
++ + ++ E + + E+E A R + K E+
Sbjct: 226 RQTDRERDRQRKTEREREKQAERERASERETERDKERER 264
Score = 40.8 bits (94), Expect = 0.004
Identities = 36/163 (22%), Positives = 80/163 (49%), Gaps = 13/163 (7%)
Query: 288 KAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAAR-LAKEKEEEEVRQQALLAKKEKDIQK 346
+A K+A+ + ++KE+E + ++RQ E E R + +E++ R++ ++++D +K
Sbjct: 44 QAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREK 103
Query: 347 KAIK-------KERQKLRNSCKTWNHFSDNEAERVK-MMEEVEKLCDRLELASLQCLNET 398
+ + ++R+K RN K ++ E ER + + ++ +R A + +T
Sbjct: 104 ERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQT 163
Query: 399 LTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTE 441
++ + +++ E N Q R+E+E R R+ TE
Sbjct: 164 DRERQRQTERNRQKEREREKNRQERRERE----RQREKENKTE 202
Score = 35.4 bits (80), Expect = 0.16
Identities = 22/105 (20%), Positives = 51/105 (48%), Gaps = 1/105 (0%)
Query: 220 NFDSWREFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPR 279
N + RE E E+E+ RD + E++ R R +++ +T D +
Sbjct: 356 NRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETE 415
Query: 280 IKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAK 324
++ +E+++ + ++ + K+K +E ++++RQ + +A R K
Sbjct: 416 KQREREKDRESERGRERGREREKQKGRE-RDRERQTDRQAGRQRK 459
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 64.7 bits (156), Expect = 2e-10
Identities = 60/254 (23%), Positives = 120/254 (47%), Gaps = 16/254 (6%)
Query: 195 KKNVPKLGDMNSSFEDVDIFYSFWYNFDSWREFSYLDEEEKEKAECRDERRWIE--KQNR 252
K+N P D SF + + ++ R ++ ++K E D+RR +E K R
Sbjct: 521 KRNTPLRMDPKCSFVEKER-----QRLENLRRKEEAEQLRRQKVE-EDKRRRLEEVKLKR 574
Query: 253 ATRAQRKKEEMNRIRTLVDNAYS-CDPRIKKFKEE-EKAKKE--AEKKAKAEAKRKEQEA 308
R ++ + R+ + + + + + E+ EKAK+E AE+KAK +A K+ E
Sbjct: 575 EERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEE 634
Query: 309 KEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSD 368
E +R+ E EA RL ++EEE R+ L +K+K+ +++ ++K + R + + +
Sbjct: 635 VEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE 694
Query: 369 NEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEE 428
E + E+ + +R E E +E + E++++E + +R +KE+
Sbjct: 695 QERREQERREQERREQERREQERQLAEQER----RREQERLQAERELQEREKALRLQKEQ 750
Query: 429 AEARMRQASKNTEK 442
+ + + K E+
Sbjct: 751 LQRELEEKKKKEEQ 764
Score = 62.0 bits (149), Expect = 2e-09
Identities = 37/140 (26%), Positives = 81/140 (57%), Gaps = 10/140 (7%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEKQNRATRAQ-----RKKEEMNRIRTLVDNAYSCDPR 279
++ ++ K++ E R RW++++ R Q +K+EE R+R + + R
Sbjct: 630 KKMEEVEARRKQEEEAR-RLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQR 688
Query: 280 IKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAK 339
++ +E+E+ ++E ++ + E +R+EQE + +++ E RL E+E +E R++AL +
Sbjct: 689 EQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQE-REKALRLQ 747
Query: 340 KE---KDIQKKAIKKERQKL 356
KE +++++K K+E+Q+L
Sbjct: 748 KEQLQRELEEKKKKEEQQRL 767
Score = 57.8 bits (138), Expect = 3e-08
Identities = 41/170 (24%), Positives = 87/170 (51%), Gaps = 8/170 (4%)
Query: 225 REFSYLDEE-----EKEKAECRDERRWIEKQNRATRAQRKKEE-MNRIRTLV--DNAYSC 276
++F+ +DE+ E+ AE + +++ K+ A+RK+EE R+R L +
Sbjct: 601 QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH 660
Query: 277 DPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQAL 336
++K KEEE+ + +AK A+++EQE +E++R+ + + +E+E E +Q
Sbjct: 661 QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 720
Query: 337 LAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDR 386
++ ++ ++ ++E Q+ + + E E K EE ++L +R
Sbjct: 721 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAER 770
Score = 34.7 bits (78), Expect = 0.27
Identities = 26/115 (22%), Positives = 60/115 (52%), Gaps = 20/115 (17%)
Query: 233 EEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKE 292
E++E+ ERR E++ + R Q ++E+ ++ + ++ +E +A++E
Sbjct: 686 EQREQERREQERREQERREQERREQERREQERQL---------AEQERRREQERLQAERE 736
Query: 293 AEKKAKAEAKRKEQ--------EAKEKQRQAELEAARLAKEKEEEEVRQQALLAK 339
+++ KA +KEQ + KE+Q++ A R +E++E++ ++ A +K
Sbjct: 737 LQEREKALRLQKEQLQRELEEKKKKEEQQRL---AERQLQEEQEKKAKEAAGASK 788
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 64.7 bits (156), Expect = 2e-10
Identities = 59/241 (24%), Positives = 112/241 (46%), Gaps = 36/241 (14%)
Query: 230 LDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKK------- 282
+D +EKE+ + RR + A + +R+K E ++ R L + + R++K
Sbjct: 528 MDPKEKERQRLENLRR----KEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER 583
Query: 283 ---FKEE----------------EKAKKE--AEKKAKAEAKRKEQEAKEKQRQAELEAAR 321
KEE EKAK+E AE+KAK +A K+ E E +R+ E EA R
Sbjct: 584 VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR 643
Query: 322 LAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVE 381
L ++EEE R+ L +K+K+ +++ ++K + R + + + E + E+
Sbjct: 644 LRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQER 703
Query: 382 KLCDRLELASLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTE 441
+ +R E E +E + E++++E + +R +KE+ + + + K E
Sbjct: 704 REQERREQERQLAEQER----RREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEE 759
Query: 442 K 442
+
Sbjct: 760 Q 760
Score = 62.0 bits (149), Expect = 2e-09
Identities = 37/140 (26%), Positives = 81/140 (57%), Gaps = 10/140 (7%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEKQNRATRAQ-----RKKEEMNRIRTLVDNAYSCDPR 279
++ ++ K++ E R RW++++ R Q +K+EE R+R + + R
Sbjct: 626 KKMEEVEARRKQEEEAR-RLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQR 684
Query: 280 IKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAK 339
++ +E+E+ ++E ++ + E +R+EQE + +++ E RL E+E +E R++AL +
Sbjct: 685 EQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQE-REKALRLQ 743
Query: 340 KE---KDIQKKAIKKERQKL 356
KE +++++K K+E+Q+L
Sbjct: 744 KEQLQRELEEKKKKEEQQRL 763
Score = 57.8 bits (138), Expect = 3e-08
Identities = 41/170 (24%), Positives = 87/170 (51%), Gaps = 8/170 (4%)
Query: 225 REFSYLDEE-----EKEKAECRDERRWIEKQNRATRAQRKKEE-MNRIRTLV--DNAYSC 276
++F+ +DE+ E+ AE + +++ K+ A+RK+EE R+R L +
Sbjct: 597 QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH 656
Query: 277 DPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQAL 336
++K KEEE+ + +AK A+++EQE +E++R+ + + +E+E E +Q
Sbjct: 657 QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 716
Query: 337 LAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDR 386
++ ++ ++ ++E Q+ + + E E K EE ++L +R
Sbjct: 717 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAER 766
Score = 55.8 bits (133), Expect = 1e-07
Identities = 54/239 (22%), Positives = 108/239 (45%), Gaps = 28/239 (11%)
Query: 232 EEEK----EKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEE 287
EE+K E+ + + E R + R ++ KEE + + D + +K KEE
Sbjct: 556 EEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKK--QIEQKFAQIDEKTEKAKEER 613
Query: 288 KAKKEAEKKAKA------EAKRKEQEA--------KEKQRQAELEAARLAKEKEEEEVRQ 333
A+++A+KKA A EA+RK++E +E++ + E + KE+E+E +R+
Sbjct: 614 LAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK 673
Query: 334 QALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQ 393
A K Q++ ++E+++ + E+ + + E E+ ++ L + +
Sbjct: 674 AA--EAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAER 731
Query: 394 CLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSK 452
L E +E ++Q++ E+ +K++E+ RQ + EK SK
Sbjct: 732 ELQE------REKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 784
Score = 36.2 bits (82), Expect = 0.092
Identities = 20/91 (21%), Positives = 48/91 (52%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK 284
RE ++E +E+ ERR E+Q +R++E + R L + + + ++ +
Sbjct: 689 REQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQ 748
Query: 285 EEEKAKKEAEKKAKAEAKRKEQEAKEKQRQA 315
E + KK+ E++ + ++ ++E ++K ++A
Sbjct: 749 RELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 64.3 bits (155), Expect = 3e-10
Identities = 42/142 (29%), Positives = 78/142 (54%), Gaps = 4/142 (2%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E+E ++ E +++R+ EK+ R ++ KE + + + R K+ +E+E+ +K
Sbjct: 103 EKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERE-RKKEEREKERERK 161
Query: 292 EAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKK 351
E +K+ + + KE+E KEK+R+ + R KE+++E R++ KKE+ +K+ KK
Sbjct: 162 ERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERK-KKEERKK 220
Query: 352 ERQKLRNSCKTWNHFSDNEAER 373
ERQK R + W + ER
Sbjct: 221 ERQKDRQT--NWREKERGKRER 240
Score = 62.0 bits (149), Expect = 2e-09
Identities = 58/206 (28%), Positives = 97/206 (47%), Gaps = 38/206 (18%)
Query: 237 KAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKK 296
++E R+ R IE TR + KKE + R K+ +E EK K+E EK+
Sbjct: 35 QSEIREREREIE-----TRKEGKKERESE-------------RKKERREREKRKREREKE 76
Query: 297 AKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKL 356
K E +KE++ + K+ + E + R +EKE +E ++ KKEK + + K+ +++
Sbjct: 77 RKRERGKKEKKGERKKEERERKKRR--REKENKEGEEKEKRKKKEKKERGRTSKEGKERE 134
Query: 357 RNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAALEKQIE 416
R + ER + EE EK +R E + K+VG EK+ E
Sbjct: 135 RKE----ERKREERKERERKKEEREKERERKERKKRE---------RKQVG----EKE-E 176
Query: 417 EINEQIRKEKEEAEARMRQASKNTEK 442
E E+ RKE+++ E ++ K E+
Sbjct: 177 ERKEKERKERKKRERNRKERKKERER 202
Score = 59.3 bits (142), Expect = 1e-08
Identities = 36/131 (27%), Positives = 73/131 (55%), Gaps = 7/131 (5%)
Query: 232 EEEKEKAECRDERRWIE-KQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAK 290
E +KE+ E + RR E K+ ++KKE+ R RT S + + ++ KEE K +
Sbjct: 89 ERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRT------SKEGKERERKEERKRE 142
Query: 291 KEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIK 350
+ E++ K E + KE+E KE++++ + +E++E+E +++ + K+ +K+ +
Sbjct: 143 ERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERER 202
Query: 351 KERQKLRNSCK 361
KER++ + K
Sbjct: 203 KERRERKKERK 213
Score = 58.9 bits (141), Expect = 1e-08
Identities = 57/224 (25%), Positives = 104/224 (46%), Gaps = 33/224 (14%)
Query: 225 REFSYLDEEEKEK-AECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKF 283
RE E +KE+ +E + ERR EK+ R +RK+E + + R K+
Sbjct: 43 REIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKK--------GERKKEE 94
Query: 284 KEEEKAKKEAE-KKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEK 342
+E +K ++E E K+ + + KRK++E KE+ R ++ KE+E +E R++ +KE+
Sbjct: 95 RERKKRRREKENKEGEEKEKRKKKEKKERGR-----TSKEGKERERKEERKRE--ERKER 147
Query: 343 DIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSC 402
+ +K+ +KER++ + + E ER + + K +R
Sbjct: 148 ERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNR-------------- 193
Query: 403 TKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKN-TEKSTG 445
KE K K+ E ++ +K++E + R + N EK G
Sbjct: 194 -KERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERG 236
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/129 (28%), Positives = 66/129 (51%), Gaps = 5/129 (3%)
Query: 231 DEEEKEKAECRDERRWIEKQN--RATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEK 288
+E+EK K + + ER K+ R + +RK+EE + R ++ K E K
Sbjct: 110 EEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERK 169
Query: 289 --AKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQK 346
+KE E+K K +RK++E K+R+ E E +E+++E +++ +++KD Q
Sbjct: 170 QVGEKEEERKEKERKERKKRERNRKERKKERERKE-RRERKKERKKKEERKKERQKDRQT 228
Query: 347 KAIKKERQK 355
+KER K
Sbjct: 229 NWREKERGK 237
Score = 35.4 bits (80), Expect = 0.16
Identities = 19/88 (21%), Positives = 46/88 (52%), Gaps = 1/88 (1%)
Query: 232 EEEKEKAECRD-ERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAK 290
E+E+E+ E + ER+ + ++ + + +KE R R + + + ++ +++E+ K
Sbjct: 155 EKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKK 214
Query: 291 KEAEKKAKAEAKRKEQEAKEKQRQAELE 318
KE KK + + ++ KE+ ++ E
Sbjct: 215 KEERKKERQKDRQTNWREKERGKRERKE 242
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 63.2 bits (152), Expect = 7e-10
Identities = 66/238 (27%), Positives = 113/238 (47%), Gaps = 32/238 (13%)
Query: 232 EEEK--EKAECRDERRWIEKQNRATRAQRKK-EEMNRIRTLVDNAYSCDPRIKKFKEEEK 288
E+EK E+ E E + +++Q + TR Q +K +E RIR R KK +EEE+
Sbjct: 415 EQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRE----------REKKMREEEE 464
Query: 289 AKKEAEKKA-KAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDI--Q 345
+E E+K K E EQE KE Q+Q RL ++K E++ +Q + ++E+ I Q
Sbjct: 465 TMREQEEKMQKQEENMWEQEEKEWQQQ------RLPEQK--EKLWEQEKMQEQEEKIWEQ 516
Query: 346 KKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKE 405
++ I+ + + K W E E +M E+ EK+ D+ + + E + T+E
Sbjct: 517 EEKIRDQEEMWGQEKKMWRQEKMREQED-QMWEQEEKMRDQEQ--KMWDQEERMEKKTQE 573
Query: 406 VGKAALE-----KQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDD 458
K + ++ E + E+ +K +EE E Q K E+ K W +++
Sbjct: 574 QEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEE 631
Score = 62.4 bits (150), Expect = 1e-09
Identities = 52/228 (22%), Positives = 113/228 (49%), Gaps = 24/228 (10%)
Query: 233 EEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIK----KFKEEEK 288
E++EK ++E+ W +++ + ++ +E+ ++R + + D R++ + +E+EK
Sbjct: 359 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEK 418
Query: 289 AKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEK------EEEEVRQQALLAKKEK 342
++ E K + E K +EQE K + ++ +++ +E+ EEE +R+Q +K++
Sbjct: 419 MWEQVE-KMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQE 477
Query: 343 DIQKKAIKKERQKLR---NSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETL 399
+ + +KE Q+ R K W E E K+ E+ EK+ D+ E+ +
Sbjct: 478 ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE-KIWEQEEKIRDQEEMWGQE------ 530
Query: 400 TSCTKEVGKAALEKQIEEINEQIRKEKE---EAEARMRQASKNTEKST 444
++ E Q+ E E++R +++ + E RM + ++ EK T
Sbjct: 531 KKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKT 578
Score = 62.0 bits (149), Expect = 2e-09
Identities = 80/419 (19%), Positives = 169/419 (40%), Gaps = 86/419 (20%)
Query: 222 DSWREFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIK 281
+ WR+ L E+EK K ++E+ W +++ R +E+ ++R + + + K
Sbjct: 273 EMWRQEEELREQEK-KIRKQEEKMWRQEE-------RLREQEGKMREQEEKMWRQE---K 321
Query: 282 KFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAEL-EAARLAKEKEEEEVRQQALLAKK 340
+ +E+EK +E EK+ + + + +EQE + ++++ ++ E +E+EE+ RQ+ L ++
Sbjct: 322 RLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ 381
Query: 341 EKDI----------------QKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLC 384
EK + Q + ++++ +++R K W E+ KM E+ +K
Sbjct: 382 EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEK-KMQEQEKKTR 440
Query: 385 DRLELASLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKST 444
D+ E ++ E I E+ +K +EE E Q K ++
Sbjct: 441 DQEEKM----------------------QEEERIREREKKMREEEETMREQEEKMQKQEE 478
Query: 445 GGGGNGSKNWSEDDLQLLIKAVNLFPAGTNSRWE---VIANYMNIHSSSGVKRTAKDVIG 501
K W + L P WE + I R +++ G
Sbjct: 479 NMWEQEEKEWQQQRL----------PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG 528
Query: 502 KAKSLQKLDPHQKDDINKKAFDKFKKEHGVVPQADNATPSERFEGPYTDFTPWTTEEQKL 561
+ K + + ++ + ++ +++E + Q E E+K
Sbjct: 529 QEKKMWR-----QEKMREQEDQMWEQEEKMRDQEQKMWDQEE------------RMEKKT 571
Query: 562 LEQALKTYPVNTPERWEKIAEAVPGRTKKDCMKRYKELVEMVKAKKAAQEQVLNASRAK 620
EQ KT+ ++ EK+ E R ++ M+ +E++ + K QE+ + K
Sbjct: 572 QEQEKKTW-----DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEK 625
Score = 54.7 bits (130), Expect = 3e-07
Identities = 51/239 (21%), Positives = 110/239 (46%), Gaps = 33/239 (13%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEK-----QNRATRAQRKKEEMNRIRTLVDNAYSCDPR 279
RE E++EK + ++E W ++ Q R + K E +++ + + + +
Sbjct: 460 REEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEK 519
Query: 280 I----------KKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEK--- 326
I KK +EK +++ ++ + E K ++QE K ++ +E +EK
Sbjct: 520 IRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTW 579
Query: 327 -EEEEVRQQALLAKKEKDI---------QKKAIKKERQKLR-NSCKTWNHFSDNEAERVK 375
+EE++R++ + ++EK + Q++ ++++ +K++ K W + + K
Sbjct: 580 DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEK 639
Query: 376 MMEEVEKLCDR----LELASLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAE 430
M E+ EK+ ++ E L E L K + +++Q E+I EQ + EK+ E
Sbjct: 640 MWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQE 698
Score = 53.5 bits (127), Expect = 6e-07
Identities = 83/450 (18%), Positives = 174/450 (38%), Gaps = 66/450 (14%)
Query: 51 QELEDKKELSEESEDEELQLEEFPMLKTLDPKDWKNQDHYAVLGLGHVRYKATQRQIKAA 110
+ L +K+E E E Q+E+ K + ++ K +D + + +R+ K
Sbjct: 404 ERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM---QEEERIREREKKMR 460
Query: 111 HKAMVLKHHPDKRKAAGEPIKEGDNDYFTCITKAYEMLSDPVKRRAFNSVDPTFDNSVPS 170
+ ++ +K + E + E + K ++ P ++ +
Sbjct: 461 EEEETMREQEEKMQKQEENMWEQEE-------KEWQQQRLPEQKEKLWEQE--------K 505
Query: 171 KSEAKDNFFEVFTPVFERNSRWSNKKNVPKLGDMNSSFEDVDIFYSFWYNFDSWR--EFS 228
E ++ +E + ++ W +K + + M + + W + R E
Sbjct: 506 MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM------WEQEEKMRDQEQK 559
Query: 229 YLDEEEK--------EKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRI 280
D+EE+ EK E + E++ R ++ +EE +R + + ++
Sbjct: 560 MWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM 619
Query: 281 -----KKFKEEEKAKKEAEKKAKAEAKRKEQEAK--EKQRQAELEAARLAKEK------- 326
K +++EEK +++ EK + E K EQE K E+QR E + EK
Sbjct: 620 QEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKM 679
Query: 327 --EEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERV-----KMMEE 379
+EE++ +Q + KK ++ +KK +E+ + S + E E + KM E+
Sbjct: 680 QEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQ 739
Query: 380 VEKLCDR-----------LELASLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEE 428
EK+ ++ E + L +++ + ++ E+I EQ K +++
Sbjct: 740 EEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQ 799
Query: 429 AEARMRQASKNTEKSTGGGGNGSKNWSEDD 458
E Q K + G K W +++
Sbjct: 800 EEKMRGQEEKMRGQEEKMRGQEEKMWGQEE 829
Score = 51.6 bits (122), Expect = 2e-06
Identities = 49/221 (22%), Positives = 106/221 (47%), Gaps = 29/221 (13%)
Query: 233 EEKEKAECRDERRWI-EKQNRATRAQRKKE-EMNRIRTLVDNAYSCDPRIKKFKEEEKAK 290
+E+EK + ++E+ W EK + T+ Q KK + ++R S R KK +EEE+
Sbjct: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR----EEESMREREKKMREEEEMM 729
Query: 291 KEAEKKAKAEAKRKEQEAKEKQRQAE---------LEAARLAKEKEE----EEVRQQALL 337
+E E+K + + ++ +++ +E Q E E RL ++KE+ E++++Q +
Sbjct: 730 REQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKI 789
Query: 338 AKKEKDI--QKKAIKKERQKLR--------NSCKTWNHFSDNEAERVKMMEEVEKLCDRL 387
++E+ + Q++ ++ + +K+R K W + KM + EK+ +
Sbjct: 790 WEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQE 849
Query: 388 ELASLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEE 428
E + + +E E+++ E E++R ++E+
Sbjct: 850 EKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890
Score = 29.6 bits (65), Expect = 8.6
Identities = 25/113 (22%), Positives = 46/113 (40%), Gaps = 7/113 (6%)
Query: 226 EFSYLDEEEK---EKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKK 282
E + E+EK ++ + RD+ + Q R Q +K + K
Sbjct: 779 EHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKM 838
Query: 283 FKEEEKA----KKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEV 331
+ +EEK +K EK E K +EQE K + ++ ++ +EE++
Sbjct: 839 WGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 63.2 bits (152), Expect = 7e-10
Identities = 58/262 (22%), Positives = 123/262 (46%), Gaps = 37/262 (14%)
Query: 222 DSWREFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIK 281
+ WR+ L E+EK K ++E+ W +++ + + +E+ ++R + K
Sbjct: 235 EMWRQEEELREQEK-KIRKQEEKMWRQEERLREQEGKMREQEEKMRR----------QEK 283
Query: 282 KFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAEL-EAARLAKEKEEEEVRQQALLAKK 340
+ +E+EK +E EK+ + + K +EQE + ++++ ++ E +E+EE+ RQ+ L ++
Sbjct: 284 RLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ 343
Query: 341 EKDI----------------QKKAIKKERQKLRNSCKTWNHFSD-NEAERV-----KMME 378
EK + Q + ++++ +++R K W E ER+ KM E
Sbjct: 344 EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMRE 403
Query: 379 EVEKLCDRLELASLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASK 438
E E + ++ E Q N KE + L +Q E++ EQ ++ +E E ++ + +
Sbjct: 404 EEETMREQEEKMQKQEEN-MWEQEEKEWQQQRLPEQKEKLWEQ--EKMQEQEEKIWEQEE 460
Query: 439 NTEKSTGGGGNGSKNWSEDDLQ 460
G K W ++ ++
Sbjct: 461 KIRDQEEMWGQEKKMWRQEKMR 482
Score = 62.8 bits (151), Expect = 9e-10
Identities = 82/426 (19%), Positives = 171/426 (40%), Gaps = 48/426 (11%)
Query: 231 DEEEKEKAECRDERRWIEKQNRATRAQRK--KEEMNRIR---------TLVDNAYSCDPR 279
+E +K+ AE +++ R E + + K K ++ R + TL + + +
Sbjct: 183 EELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE 242
Query: 280 IKKF-----KEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQ 334
+++ K+EEK ++ E+ + E K +EQE K ++++ L ++E+E+R+Q
Sbjct: 243 LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQ 302
Query: 335 ALLAKKEKDIQ----------KKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLC 384
L ++E+ +Q +K ++E + R + W + KM ++ E++
Sbjct: 303 KKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW 362
Query: 385 DRLELASLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKST 444
++ E L+ E + K + ++ E I E+ +K +EE E Q K ++
Sbjct: 363 EQDE--RLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEE 420
Query: 445 GGGGNGSKNWSEDDLQLLIKAVNLFPAGTNSRWE---VIANYMNIHSSSGVKRTAKDVIG 501
K W + L P WE + I R +++ G
Sbjct: 421 NMWEQEEKEWQQQRL----------PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG 470
Query: 502 KAKSL--QKLDPHQKDDINKKAFDKFKKEHGVVPQADNATPS-----ERFEGPYTDFTPW 554
+ K + Q+ Q+D + ++ +E + Q + E+ E W
Sbjct: 471 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMW 530
Query: 555 TTEEQKLLEQALKTYPVNTPERWEKIAEAVPGRTKKDCMKRYKELVEMVKAKKAAQEQVL 614
EE+ E+ + T ++ EK+ E R ++ M+ +E++ + K QE+ +
Sbjct: 531 QQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM 590
Query: 615 NASRAK 620
K
Sbjct: 591 REQEEK 596
Score = 54.3 bits (129), Expect = 3e-07
Identities = 50/226 (22%), Positives = 110/226 (48%), Gaps = 23/226 (10%)
Query: 218 WYNFDSWREFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCD 277
W + RE E+EK+ + ++ R E+ + R++EEM R +
Sbjct: 530 WQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR-----------E 578
Query: 278 PRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAK---EKQRQAELEAARLAKEKEEEEVRQQ 334
K ++EEK +++ EK + E K +EQE K ++++ E E +E+EE Q+
Sbjct: 579 QEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQE 638
Query: 335 ALLAKKEKDI--QKKAIKKERQKLRNSCKTWNHFSDNEAER-VKMMEEVEKLCDRLELAS 391
+ ++E+ + Q++ ++++ +K+R + + E+ KM + EK+ ++ E
Sbjct: 639 EKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEE--K 696
Query: 392 LQCLNETLTSCTKEV----GKAALEKQIEEINEQIRKEKEEAEARM 433
++ E + +++ K ++++ E E+IR +KE+ + R+
Sbjct: 697 MRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERL 742
Score = 53.5 bits (127), Expect = 6e-07
Identities = 47/228 (20%), Positives = 101/228 (44%), Gaps = 31/228 (13%)
Query: 231 DEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAK 290
DE +EK E E++ + +Q R ++K +E + + +K +EEE+ +
Sbjct: 513 DERLREKEERMREQKKMWQQEEKMREEKKTQEQEK---------KTWDQEEKMREEERMR 563
Query: 291 KEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIK 350
+ +K + E +EQE K ++++ ++ +E+EE+ Q+ + ++E+ + ++ K
Sbjct: 564 EREKKMREEEEMMREQEEKMQEQEEKM------REQEEKMWEQEEKMQEQEEKMWEQEEK 617
Query: 351 KERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAA 410
Q+ + + + E KM E+ EK+ ++ E Q +
Sbjct: 618 MWEQEEEDKMQEQEEMMWEQEE--KMQEQEEKMWEQEEKMREQ--------------EEK 661
Query: 411 LEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDD 458
+ +Q E++ Q K +E+ E Q K E+ G K W +++
Sbjct: 662 MREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEE 709
Score = 48.9 bits (115), Expect = 1e-05
Identities = 45/238 (18%), Positives = 112/238 (47%), Gaps = 10/238 (4%)
Query: 231 DEEEKEKAE-CRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEE--E 287
DE +EK E R++ + E++ + +R +E ++R + + +++K +E E
Sbjct: 365 DERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 424
Query: 288 KAKKEAEKKAKAEAKRK--EQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQ 345
+ +KE +++ E K K EQE ++Q + E +++EE +++ + +++ Q
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 484
Query: 346 KKAIKKERQKLRN-SCKTWNHFSDNEAERVKMMEEVEKLCDRLEL----ASLQCLNETLT 400
+ + ++ +K+R+ K W+ + ++ E+ E++ ++ ++ ++ +T
Sbjct: 485 EDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQE 544
Query: 401 SCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDD 458
K + ++ E + E+ +K +EE E Q K E+ K W +++
Sbjct: 545 QEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEE 602
Score = 48.1 bits (113), Expect = 2e-05
Identities = 51/218 (23%), Positives = 101/218 (46%), Gaps = 39/218 (17%)
Query: 218 WYNFDSWREFSYLDEEEKEKAE----CRDERRWIEKQNRATRAQRKK--EEMNRIRTLVD 271
W + RE + E EK+ E R++ +++Q R Q +K E+ +++ +
Sbjct: 550 WDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEE 609
Query: 272 NAYSCDPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAK-----EKQRQAELEAARLAKEK 326
+ + ++ + +EE+K +++ E + E K +EQE K EK R+ E E R +EK
Sbjct: 610 KMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQE-EKMREQEEK 668
Query: 327 ---EEEEVRQQALLAKKEKDIQKKAIKKERQKLR---------------NSCKTWNHFSD 368
+EE++R+Q +++ Q++ ++++ +K+R K W
Sbjct: 669 MQGQEEKMREQ----EEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEM 724
Query: 369 NEAERVKMMEEVEKLCDRL----ELASLQCLNETLTSC 402
E E ++ ++ EK+ +RL E S CL + C
Sbjct: 725 REKEE-RIRDQKEKMQERLPEHEERCSEPCLPPSKVLC 761
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 62.8 bits (151), Expect = 9e-10
Identities = 49/194 (25%), Positives = 99/194 (51%), Gaps = 14/194 (7%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEA 293
E+ + +E R +E+Q +A A++ K ++ L + R ++ ++E + +KE
Sbjct: 460 ERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKEREREKEL 519
Query: 294 EKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKER 353
EK+ + E +++ ++ +E+Q++ E E L KE+E++ ++ +KEK++++ +KE+
Sbjct: 520 EKEQEQEREKEREKDRERQQEKEKE---LEKEQEKQREMEKERKQEKEKELER---QKEK 573
Query: 354 QKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAALEK 413
+K K + E ER K+ E++E LE + E+ SC KE E+
Sbjct: 574 EKELQKMKEQEKECELEKEREKLEEKIEPREPNLE--PMVEKQESENSCNKE------EE 625
Query: 414 QIEEINEQIRKEKE 427
+ + R EKE
Sbjct: 626 PVFTRQDSNRSEKE 639
Score = 58.2 bits (139), Expect = 2e-08
Identities = 61/216 (28%), Positives = 101/216 (46%), Gaps = 21/216 (9%)
Query: 231 DEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAK 290
DE+E K R + E RA++++EE R R +C ++K+ E+
Sbjct: 440 DEDEIWKQRRRQQS---EISAAVERARKRREEEER-RMEEQRKAACAEKLKRLDEKLGI- 494
Query: 291 KEAEKKAKAEAKRKEQEAKEKQRQAELEAAR---LAKEKEEEEVRQQALLAKKEKDIQKK 347
EK+ E R+ + KE++R+ ELE + KE+E++ RQQ +KEK+++
Sbjct: 495 --LEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQ----EKEKELE-- 546
Query: 348 AIKKERQKLRNSCKTWNHFSDNEAERVKMME-EVEKLCDRLELASLQCLNETLTSCTKEV 406
KE++K R K + E ER K E E++K+ ++ + L+ E L E
Sbjct: 547 ---KEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEE-KIEP 602
Query: 407 GKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
+ LE +E+ + KEE RQ S +EK
Sbjct: 603 REPNLEPMVEKQESENSCNKEEEPVFTRQDSNRSEK 638
Score = 48.9 bits (115), Expect = 1e-05
Identities = 47/221 (21%), Positives = 94/221 (42%), Gaps = 43/221 (19%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK 284
+E E+E+EK +D R EK+ + Q K+ EM +
Sbjct: 517 KELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEK------------------- 557
Query: 285 EEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDI 344
E K +KE E + + E +++ Q+ KE++++ ELE KE+E+ E + + +E ++
Sbjct: 558 -ERKQEKEKELERQKEKEKELQKMKEQEKECELE-----KEREKLEEK----IEPREPNL 607
Query: 345 QKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTK 404
+ E+Q+ NSC + E E V ++ +R E + ++ET
Sbjct: 608 EPMV---EKQESENSC-------NKEEEPVFTRQD----SNRSEKEATPVVHETEPESGS 653
Query: 405 EVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTG 445
+ A L ++ + + + + +M+Q ++ G
Sbjct: 654 QPRPAVLSGYFKQFQKSLPPRFQRQQEQMKQQQWQQQQQQG 694
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 61.6 bits (148), Expect = 2e-09
Identities = 87/394 (22%), Positives = 172/394 (43%), Gaps = 71/394 (18%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQR--KKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E+ + +E R + Q AT QR + E+ +R + +E E K+
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA-------------RAEEAEAQKR 1490
Query: 292 EAEKKAKAEAKRKEQEAKEKQRQAELE-AARLAKEKEEEEVRQQALLAKKEKDIQKKAIK 350
+A+++A+ +R+ Q+ +++RQAE+E A+R+ E E +Q+AL A +E +Q +
Sbjct: 1491 QAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ---AE 1546
Query: 351 KERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAA 410
+ ++LR + E ER + ++ + R A LQ + T A
Sbjct: 1547 EAERRLRQA----------EVERARQVQVALETAQRSAEAELQSKRASFAEKT-----AQ 1591
Query: 411 LEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNLFP 470
LE+ ++E + + + +EEAE R +Q ++ ++ +E +L+
Sbjct: 1592 LERSLQEEHVAVAQLREEAERRAQQQAE---------AERAREEAERELE---------- 1632
Query: 471 AGTNSRWEVIANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKKAFDKFKKEHG 530
RW++ AN + ++ A++V + Q QK++ ++A + K E
Sbjct: 1633 -----RWQLKAN-----EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1682
Query: 531 VVPQADNATPSERFEGPYTDFTPWTTEEQKLLEQALKTYPVNTP--ERWEKIAEAVPGRT 588
V Q + A E+ T +++ EQ L T E+ ++ E R
Sbjct: 1683 AVRQRELA---EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1739
Query: 589 KKD--CMKRYKELVEMVKAKKAAQEQVLNASRAK 620
+++ + ++ +E AK A+ +VL AS+A+
Sbjct: 1740 QREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Score = 57.8 bits (138), Expect = 3e-08
Identities = 74/300 (24%), Positives = 129/300 (43%), Gaps = 37/300 (12%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E +E+AE R+ RW K N A R + + EE+ + ++L E EK K+
Sbjct: 1621 ERAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQ------------AEAEKQKE 1667
Query: 292 EAEKKAKAEAKRKEQEAK---------EKQRQAELEAARLAKEKEEEEVRQQALLAKKEK 342
EAE++A+ K +EQ + EKQRQ A+ E+E +R +A + E+
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1727
Query: 343 DIQKKAIKKERQKL-RNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTS 401
Q++ +++E +L R + + EAE K+ E+E L LAS E S
Sbjct: 1728 --QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL-----LASKARAEEESRS 1780
Query: 402 CTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQL 461
T E K LE + +E E AR+R ++ ++ + + ++
Sbjct: 1781 -TSEKSKQRLEAEAGRF-----RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 462 LIKAVNLFPAGTNSRWEV-IANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKK 520
L + + T + E IA + ++R A+D + + L++ K DI ++
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894
Score = 54.3 bits (129), Expect = 3e-07
Identities = 51/214 (23%), Positives = 99/214 (46%), Gaps = 21/214 (9%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK 284
+E + L+ + + +ERR E + R ++ +EE R R A R+K
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA---ALEEVERLKAKV 2018
Query: 285 EEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDI 344
EE + +E ++ A + QEA +K+ QAE +A A +++E+E++Q ++E+ +
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ---TLQQEQSV 2075
Query: 345 QKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTK 404
+ ++ E + R + + EAE ++ E E R ++ + L ++
Sbjct: 2076 LDQ-LRGEAEAARRAAE--------EAEEARVQAEREAAQSRRQVEEAERLKQSAEE--- 2123
Query: 405 EVGKAALEKQIEEINEQIRKEKEEAEARMRQASK 438
+A Q + E++RKE E+ AR QA +
Sbjct: 2124 ---QAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2154
Score = 53.9 bits (128), Expect = 4e-07
Identities = 49/172 (28%), Positives = 85/172 (49%), Gaps = 15/172 (8%)
Query: 277 DPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQR-QAELEAARLAKEKEEEEVRQQA 335
+ R+ + + E+ ++ AE +A E +R+ EA + + QAE EA L + +EE VR++
Sbjct: 1347 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1406
Query: 336 LLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAE-----RVKMMEEVEKLCDRLELA 390
A + QK++I++E Q+LR S + +AE R+++ EE+ + +LE
Sbjct: 1407 --AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464
Query: 391 SLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
Q E AL + EE Q R+ +EEAE RQ +++
Sbjct: 1465 ERQ-------RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509
Score = 53.5 bits (127), Expect = 6e-07
Identities = 62/239 (25%), Positives = 108/239 (45%), Gaps = 39/239 (16%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E++++ AE + + ++ QR +EE+ R +A + K+ +EE +
Sbjct: 1370 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ----QQKRSIQEELQQL 1425
Query: 292 EAEKKAKAEAKRKEQEAKEKQR---QAELEAARLAKEKEEE-----EVRQQALLAK-KEK 342
+A+ +AK ++ EA E+ R + E+ RL E E E QAL A+ +E
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1485
Query: 343 DIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSC 402
+ QK+ ++E ++LR + +E++R K EVE L S
Sbjct: 1486 EAQKRQAQEEAERLRRQVQ-------DESQR-KRQAEVE-----------------LASR 1520
Query: 403 TKEVGKAALEKQ-IEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQ 460
K +AA EKQ + E++R + EEAE R+RQA + ++ +E +LQ
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1579
Score = 48.9 bits (115), Expect = 1e-05
Identities = 53/220 (24%), Positives = 103/220 (46%), Gaps = 28/220 (12%)
Query: 233 EEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKE 292
EE E+A + ER A +++R+ EE R++ + R + EK +KE
Sbjct: 2091 EEAEEARVQAER-------EAAQSRRQVEEAERLKQSAEE--QAQARAQAQAAAEKLRKE 2141
Query: 293 AEKKAKAEAKRKEQEAKEKQ-RQAELEAARLAKE---KEEEEVRQQAL---LAKKEKDIQ 345
AE++A A+ ++ ++KQ AE+E + E +++ +V Q+ L +E D Q
Sbjct: 2142 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2201
Query: 346 KKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKE 405
K + +E Q+L+ EA R + E E R+++ L L + + +
Sbjct: 2202 KNLLDEELQRLKAEA--------TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2253
Query: 406 V---GKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
+ K ++ ++E E++++ EEA AR+ A++ +
Sbjct: 2254 LILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSVAAQEAAR 2292
Score = 45.8 bits (107), Expect = 1e-04
Identities = 64/245 (26%), Positives = 106/245 (43%), Gaps = 44/245 (17%)
Query: 232 EEEKEKAECRDERRW----------------IEKQNR---ATRAQRKKEEMNRIRTLVDN 272
E++KE+AE RR +EKQ + T QR E IR +
Sbjct: 1663 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1722
Query: 273 AYSCDPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVR 332
R + EEE A+ + E A A KR+E EA+ + +AE+E +K + EEE R
Sbjct: 1723 EQGEQQR--QLLEEELARLQREAAA-ATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 333 QQALLAKK-------------EKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERV----- 374
+ +K+ E+ + +A+ +E ++ R + EAERV
Sbjct: 1780 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Query: 375 KMMEEVEKLCDRLELA--SLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEAR 432
+ E +L E+A + NE L ++ +A +++EE Q + + EE A+
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAED--EAFQRRRLEEQAAQHKADIEERLAQ 1897
Query: 433 MRQAS 437
+R+AS
Sbjct: 1898 LRKAS 1902
Score = 45.4 bits (106), Expect = 2e-04
Identities = 49/207 (23%), Positives = 97/207 (46%), Gaps = 21/207 (10%)
Query: 239 ECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAK 298
E +R E++ A Q+K++E+ + TL D + + E +A + A ++A+
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQ--TLQQEQSVLD----QLRGEAEAARRAAEEAE 2094
Query: 299 AEAKRKEQEAKEKQRQAELEAARL---AKEKEEEEVRQQALLAKKEKDIQKKAIKKERQK 355
+ E+EA + +RQ E EA RL A+E+ + + QA K K+ +++A + R +
Sbjct: 2095 EARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR--RAQ 2151
Query: 356 LRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAALEKQI 415
+ +D E E+ K E L + + LT+ ++ + +K +
Sbjct: 2152 AEQAALRQKQAADAEMEKHKKFAE-------QTLRQKAQVEQELTTLRLQLEETDHQKNL 2204
Query: 416 EEINEQIRKEKEEAEARMRQASKNTEK 442
++E++++ K EA RQ S+ E+
Sbjct: 2205 --LDEELQRLKAEATEAARQRSQVEEE 2229
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/275 (20%), Positives = 124/275 (45%), Gaps = 28/275 (10%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEA 293
E +A+ R E + Q +A+ E+++R + ++ +++ E
Sbjct: 2391 EMSRAQARAEE---DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2447
Query: 294 EKKAKAEAKRK----EQEAKEKQ-RQAELEAARLAKEKEEEEVRQQALLAKKEKDIQK-K 347
++A AE +R+ +QEAK Q + E++ + + +E + QQ+ L++K+ +Q+ +
Sbjct: 2448 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2507
Query: 348 AIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTK--- 404
I++E+ KL F D A+ ++ EE ++ ++E Q L ++ +
Sbjct: 2508 FIEQEKAKLEQL------FQDEVAKAQQLREEQQRQQQQME-QERQRLVASMEEARRRQH 2560
Query: 405 --EVGKAALEKQIEEINEQIRKEKE---EAEARMRQASKNTEKSTGGGGNGSKNWSEDDL 459
E G +++++++ +Q R+++E E R+R+ + E+ + SE+
Sbjct: 2561 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ----HRAALAHSEEVT 2616
Query: 460 QLLIKAVNLFPAGTNSRWEVIANYMNIHSSSGVKR 494
+ A P G ++ A HS G++R
Sbjct: 2617 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR 2651
Score = 42.0 bits (97), Expect = 0.002
Identities = 52/224 (23%), Positives = 107/224 (47%), Gaps = 23/224 (10%)
Query: 230 LDEE----EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKE 285
LDEE + E E +R +E++ + R Q EE+++++ ++ + R ++
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIE----AENRALILRD 2258
Query: 286 EEKAKKEAEKKAKAEAKRKEQEAKEKQRQ--AELEAARLAKEKEEEEVRQQALLAKKEKD 343
++ ++ ++ EA++ +Q A+E R A EAARL + EE+ +Q+AL K K
Sbjct: 2259 KDNTQRFLQE----EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK- 2313
Query: 344 IQKKAIKKERQKLRNSCKTWNHFSDNEAERV-KMMEEVEKLCDRL--ELASLQCLNETLT 400
+K +E +L+ + + E+ ++ E+ E++ +L E Q E
Sbjct: 2314 -EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2372
Query: 401 SCTKEVGKAA--LEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
E+ A L+ ++ E++ + +E+A+ +QA + EK
Sbjct: 2373 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2416
Score = 33.9 bits (76), Expect = 0.46
Identities = 50/215 (23%), Positives = 86/215 (40%), Gaps = 27/215 (12%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCD---------PRIKK 282
E+ K++ E + R+ E A R + EE R R L + + ++
Sbjct: 1783 EKSKQRLEA-EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841
Query: 283 FKEEEKAKKEAE-----KKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALL 337
E + K EAE K+A+ E R+ E + QR+ E A K EE + Q
Sbjct: 1842 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901
Query: 338 AKKEKDIQK----KAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQ 393
+ E + QK +++ RQ F A + ++ E+ ++ E
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE----- 1956
Query: 394 CLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEE 428
+TL S + +AA ++Q+ E+ R+E EE
Sbjct: 1957 ---DTLRSKEQAELEAARQRQLAAEEERRRREAEE 1988
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 61.6 bits (148), Expect = 2e-09
Identities = 87/394 (22%), Positives = 172/394 (43%), Gaps = 71/394 (18%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQR--KKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E+ + +E R + Q AT QR + E+ +R + +E E K+
Sbjct: 1448 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA-------------RAEEAEAQKR 1494
Query: 292 EAEKKAKAEAKRKEQEAKEKQRQAELE-AARLAKEKEEEEVRQQALLAKKEKDIQKKAIK 350
+A+++A+ +R+ Q+ +++RQAE+E A+R+ E E +Q+AL A +E +Q +
Sbjct: 1495 QAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ---AE 1550
Query: 351 KERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAA 410
+ ++LR + E ER + ++ + R A LQ + T A
Sbjct: 1551 EAERRLRQA----------EVERARQVQVALETAQRSAEAELQSKRASFAEKT-----AQ 1595
Query: 411 LEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNLFP 470
LE+ ++E + + + +EEAE R +Q ++ ++ +E +L+
Sbjct: 1596 LERSLQEEHVAVAQLREEAERRAQQQAE---------AERAREEAERELE---------- 1636
Query: 471 AGTNSRWEVIANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKKAFDKFKKEHG 530
RW++ AN + ++ A++V + Q QK++ ++A + K E
Sbjct: 1637 -----RWQLKAN-----EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1686
Query: 531 VVPQADNATPSERFEGPYTDFTPWTTEEQKLLEQALKTYPVNTP--ERWEKIAEAVPGRT 588
V Q + A E+ T +++ EQ L T E+ ++ E R
Sbjct: 1687 AVRQRELA---EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1743
Query: 589 KKD--CMKRYKELVEMVKAKKAAQEQVLNASRAK 620
+++ + ++ +E AK A+ +VL AS+A+
Sbjct: 1744 QREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1777
Score = 57.8 bits (138), Expect = 3e-08
Identities = 74/300 (24%), Positives = 129/300 (43%), Gaps = 37/300 (12%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E +E+AE R+ RW K N A R + + EE+ + ++L E EK K+
Sbjct: 1625 ERAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQ------------AEAEKQKE 1671
Query: 292 EAEKKAKAEAKRKEQEAK---------EKQRQAELEAARLAKEKEEEEVRQQALLAKKEK 342
EAE++A+ K +EQ + EKQRQ A+ E+E +R +A + E+
Sbjct: 1672 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1731
Query: 343 DIQKKAIKKERQKL-RNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTS 401
Q++ +++E +L R + + EAE K+ E+E L LAS E S
Sbjct: 1732 --QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL-----LASKARAEEESRS 1784
Query: 402 CTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQL 461
T E K LE + +E E AR+R ++ ++ + + ++
Sbjct: 1785 -TSEKSKQRLEAEAGRF-----RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1838
Query: 462 LIKAVNLFPAGTNSRWEV-IANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKK 520
L + + T + E IA + ++R A+D + + L++ K DI ++
Sbjct: 1839 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1898
Score = 54.3 bits (129), Expect = 3e-07
Identities = 51/214 (23%), Positives = 99/214 (46%), Gaps = 21/214 (9%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK 284
+E + L+ + + +ERR E + R ++ +EE R R A R+K
Sbjct: 1966 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA---ALEEVERLKAKV 2022
Query: 285 EEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDI 344
EE + +E ++ A + QEA +K+ QAE +A A +++E+E++Q ++E+ +
Sbjct: 2023 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ---TLQQEQSV 2079
Query: 345 QKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTK 404
+ ++ E + R + + EAE ++ E E R ++ + L ++
Sbjct: 2080 LDQ-LRGEAEAARRAAE--------EAEEARVQAEREAAQSRRQVEEAERLKQSAEE--- 2127
Query: 405 EVGKAALEKQIEEINEQIRKEKEEAEARMRQASK 438
+A Q + E++RKE E+ AR QA +
Sbjct: 2128 ---QAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2158
Score = 53.9 bits (128), Expect = 4e-07
Identities = 49/172 (28%), Positives = 85/172 (49%), Gaps = 15/172 (8%)
Query: 277 DPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQR-QAELEAARLAKEKEEEEVRQQA 335
+ R+ + + E+ ++ AE +A E +R+ EA + + QAE EA L + +EE VR++
Sbjct: 1351 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1410
Query: 336 LLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAE-----RVKMMEEVEKLCDRLELA 390
A + QK++I++E Q+LR S + +AE R+++ EE+ + +LE
Sbjct: 1411 --AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1468
Query: 391 SLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
Q E AL + EE Q R+ +EEAE RQ +++
Sbjct: 1469 ERQ-------RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1513
Score = 53.5 bits (127), Expect = 6e-07
Identities = 62/239 (25%), Positives = 108/239 (45%), Gaps = 39/239 (16%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E++++ AE + + ++ QR +EE+ R +A + K+ +EE +
Sbjct: 1374 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ----QQKRSIQEELQQL 1429
Query: 292 EAEKKAKAEAKRKEQEAKEKQR---QAELEAARLAKEKEEE-----EVRQQALLAK-KEK 342
+A+ +AK ++ EA E+ R + E+ RL E E E QAL A+ +E
Sbjct: 1430 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1489
Query: 343 DIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSC 402
+ QK+ ++E ++LR + +E++R K EVE L S
Sbjct: 1490 EAQKRQAQEEAERLRRQVQ-------DESQR-KRQAEVE-----------------LASR 1524
Query: 403 TKEVGKAALEKQ-IEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQ 460
K +AA EKQ + E++R + EEAE R+RQA + ++ +E +LQ
Sbjct: 1525 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1583
Score = 48.9 bits (115), Expect = 1e-05
Identities = 53/220 (24%), Positives = 103/220 (46%), Gaps = 28/220 (12%)
Query: 233 EEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKE 292
EE E+A + ER A +++R+ EE R++ + R + EK +KE
Sbjct: 2095 EEAEEARVQAER-------EAAQSRRQVEEAERLKQSAEE--QAQARAQAQAAAEKLRKE 2145
Query: 293 AEKKAKAEAKRKEQEAKEKQ-RQAELEAARLAKE---KEEEEVRQQAL---LAKKEKDIQ 345
AE++A A+ ++ ++KQ AE+E + E +++ +V Q+ L +E D Q
Sbjct: 2146 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2205
Query: 346 KKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKE 405
K + +E Q+L+ EA R + E E R+++ L L + + +
Sbjct: 2206 KNLLDEELQRLKAEA--------TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2257
Query: 406 V---GKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
+ K ++ ++E E++++ EEA AR+ A++ +
Sbjct: 2258 LILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSVAAQEAAR 2296
Score = 45.8 bits (107), Expect = 1e-04
Identities = 64/245 (26%), Positives = 106/245 (43%), Gaps = 44/245 (17%)
Query: 232 EEEKEKAECRDERRW----------------IEKQNR---ATRAQRKKEEMNRIRTLVDN 272
E++KE+AE RR +EKQ + T QR E IR +
Sbjct: 1667 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1726
Query: 273 AYSCDPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVR 332
R + EEE A+ + E A A KR+E EA+ + +AE+E +K + EEE R
Sbjct: 1727 EQGEQQR--QLLEEELARLQREAAA-ATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1783
Query: 333 QQALLAKK-------------EKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERV----- 374
+ +K+ E+ + +A+ +E ++ R + EAERV
Sbjct: 1784 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1843
Query: 375 KMMEEVEKLCDRLELA--SLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEAR 432
+ E +L E+A + NE L ++ +A +++EE Q + + EE A+
Sbjct: 1844 AAIGEATRLKTEAEIALKEKEAENERLRRLAED--EAFQRRRLEEQAAQHKADIEERLAQ 1901
Query: 433 MRQAS 437
+R+AS
Sbjct: 1902 LRKAS 1906
Score = 45.4 bits (106), Expect = 2e-04
Identities = 49/207 (23%), Positives = 97/207 (46%), Gaps = 21/207 (10%)
Query: 239 ECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAK 298
E +R E++ A Q+K++E+ + TL D + + E +A + A ++A+
Sbjct: 2045 EAAQKRLQAEEKAHAFAVQQKEQELQQ--TLQQEQSVLD----QLRGEAEAARRAAEEAE 2098
Query: 299 AEAKRKEQEAKEKQRQAELEAARL---AKEKEEEEVRQQALLAKKEKDIQKKAIKKERQK 355
+ E+EA + +RQ E EA RL A+E+ + + QA K K+ +++A + R +
Sbjct: 2099 EARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR--RAQ 2155
Query: 356 LRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAALEKQI 415
+ +D E E+ K E L + + LT+ ++ + +K +
Sbjct: 2156 AEQAALRQKQAADAEMEKHKKFAE-------QTLRQKAQVEQELTTLRLQLEETDHQKNL 2208
Query: 416 EEINEQIRKEKEEAEARMRQASKNTEK 442
++E++++ K EA RQ S+ E+
Sbjct: 2209 --LDEELQRLKAEATEAARQRSQVEEE 2233
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/275 (20%), Positives = 124/275 (45%), Gaps = 28/275 (10%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEA 293
E +A+ R E + Q +A+ E+++R + ++ +++ E
Sbjct: 2395 EMSRAQARAEE---DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2451
Query: 294 EKKAKAEAKRK----EQEAKEKQ-RQAELEAARLAKEKEEEEVRQQALLAKKEKDIQK-K 347
++A AE +R+ +QEAK Q + E++ + + +E + QQ+ L++K+ +Q+ +
Sbjct: 2452 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2511
Query: 348 AIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTK--- 404
I++E+ KL F D A+ ++ EE ++ ++E Q L ++ +
Sbjct: 2512 FIEQEKAKLEQL------FQDEVAKAQQLREEQQRQQQQME-QERQRLVASMEEARRRQH 2564
Query: 405 --EVGKAALEKQIEEINEQIRKEKE---EAEARMRQASKNTEKSTGGGGNGSKNWSEDDL 459
E G +++++++ +Q R+++E E R+R+ + E+ + SE+
Sbjct: 2565 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ----HRAALAHSEEVT 2620
Query: 460 QLLIKAVNLFPAGTNSRWEVIANYMNIHSSSGVKR 494
+ A P G ++ A HS G++R
Sbjct: 2621 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR 2655
Score = 42.0 bits (97), Expect = 0.002
Identities = 52/224 (23%), Positives = 107/224 (47%), Gaps = 23/224 (10%)
Query: 230 LDEE----EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKE 285
LDEE + E E +R +E++ + R Q EE+++++ ++ + R ++
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIE----AENRALILRD 2262
Query: 286 EEKAKKEAEKKAKAEAKRKEQEAKEKQRQ--AELEAARLAKEKEEEEVRQQALLAKKEKD 343
++ ++ ++ EA++ +Q A+E R A EAARL + EE+ +Q+AL K K
Sbjct: 2263 KDNTQRFLQE----EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK- 2317
Query: 344 IQKKAIKKERQKLRNSCKTWNHFSDNEAERV-KMMEEVEKLCDRL--ELASLQCLNETLT 400
+K +E +L+ + + E+ ++ E+ E++ +L E Q E
Sbjct: 2318 -EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2376
Query: 401 SCTKEVGKAA--LEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
E+ A L+ ++ E++ + +E+A+ +QA + EK
Sbjct: 2377 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2420
Score = 33.9 bits (76), Expect = 0.46
Identities = 50/215 (23%), Positives = 86/215 (40%), Gaps = 27/215 (12%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCD---------PRIKK 282
E+ K++ E + R+ E A R + EE R R L + + ++
Sbjct: 1787 EKSKQRLEA-EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1845
Query: 283 FKEEEKAKKEAE-----KKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALL 337
E + K EAE K+A+ E R+ E + QR+ E A K EE + Q
Sbjct: 1846 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1905
Query: 338 AKKEKDIQK----KAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQ 393
+ E + QK +++ RQ F A + ++ E+ ++ E
Sbjct: 1906 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE----- 1960
Query: 394 CLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEE 428
+TL S + +AA ++Q+ E+ R+E EE
Sbjct: 1961 ---DTLRSKEQAELEAARQRQLAAEEERRRREAEE 1992
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 61.6 bits (148), Expect = 2e-09
Identities = 87/394 (22%), Positives = 172/394 (43%), Gaps = 71/394 (18%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQR--KKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E+ + +E R + Q AT QR + E+ +R + +E E K+
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA-------------RAEEAEAQKR 1490
Query: 292 EAEKKAKAEAKRKEQEAKEKQRQAELE-AARLAKEKEEEEVRQQALLAKKEKDIQKKAIK 350
+A+++A+ +R+ Q+ +++RQAE+E A+R+ E E +Q+AL A +E +Q +
Sbjct: 1491 QAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ---AE 1546
Query: 351 KERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAA 410
+ ++LR + E ER + ++ + R A LQ + T A
Sbjct: 1547 EAERRLRQA----------EVERARQVQVALETAQRSAEAELQSKRASFAEKT-----AQ 1591
Query: 411 LEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNLFP 470
LE+ ++E + + + +EEAE R +Q ++ ++ +E +L+
Sbjct: 1592 LERSLQEEHVAVAQLREEAERRAQQQAE---------AERAREEAERELE---------- 1632
Query: 471 AGTNSRWEVIANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKKAFDKFKKEHG 530
RW++ AN + ++ A++V + Q QK++ ++A + K E
Sbjct: 1633 -----RWQLKAN-----EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1682
Query: 531 VVPQADNATPSERFEGPYTDFTPWTTEEQKLLEQALKTYPVNTP--ERWEKIAEAVPGRT 588
V Q + A E+ T +++ EQ L T E+ ++ E R
Sbjct: 1683 AVRQRELA---EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1739
Query: 589 KKD--CMKRYKELVEMVKAKKAAQEQVLNASRAK 620
+++ + ++ +E AK A+ +VL AS+A+
Sbjct: 1740 QREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Score = 57.8 bits (138), Expect = 3e-08
Identities = 74/300 (24%), Positives = 129/300 (43%), Gaps = 37/300 (12%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E +E+AE R+ RW K N A R + + EE+ + ++L E EK K+
Sbjct: 1621 ERAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQ------------AEAEKQKE 1667
Query: 292 EAEKKAKAEAKRKEQEAK---------EKQRQAELEAARLAKEKEEEEVRQQALLAKKEK 342
EAE++A+ K +EQ + EKQRQ A+ E+E +R +A + E+
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1727
Query: 343 DIQKKAIKKERQKL-RNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTS 401
Q++ +++E +L R + + EAE K+ E+E L LAS E S
Sbjct: 1728 --QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL-----LASKARAEEESRS 1780
Query: 402 CTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQL 461
T E K LE + +E E AR+R ++ ++ + + ++
Sbjct: 1781 -TSEKSKQRLEAEAGRF-----RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 462 LIKAVNLFPAGTNSRWEV-IANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKK 520
L + + T + E IA + ++R A+D + + L++ K DI ++
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894
Score = 54.3 bits (129), Expect = 3e-07
Identities = 51/214 (23%), Positives = 99/214 (46%), Gaps = 21/214 (9%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK 284
+E + L+ + + +ERR E + R ++ +EE R R A R+K
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA---ALEEVERLKAKV 2018
Query: 285 EEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDI 344
EE + +E ++ A + QEA +K+ QAE +A A +++E+E++Q ++E+ +
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ---TLQQEQSV 2075
Query: 345 QKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTK 404
+ ++ E + R + + EAE ++ E E R ++ + L ++
Sbjct: 2076 LDQ-LRGEAEAARRAAE--------EAEEARVQAEREAAQSRRQVEEAERLKQSAEE--- 2123
Query: 405 EVGKAALEKQIEEINEQIRKEKEEAEARMRQASK 438
+A Q + E++RKE E+ AR QA +
Sbjct: 2124 ---QAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2154
Score = 53.9 bits (128), Expect = 4e-07
Identities = 49/172 (28%), Positives = 85/172 (49%), Gaps = 15/172 (8%)
Query: 277 DPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQR-QAELEAARLAKEKEEEEVRQQA 335
+ R+ + + E+ ++ AE +A E +R+ EA + + QAE EA L + +EE VR++
Sbjct: 1347 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1406
Query: 336 LLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAE-----RVKMMEEVEKLCDRLELA 390
A + QK++I++E Q+LR S + +AE R+++ EE+ + +LE
Sbjct: 1407 --AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464
Query: 391 SLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
Q E AL + EE Q R+ +EEAE RQ +++
Sbjct: 1465 ERQ-------RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509
Score = 53.5 bits (127), Expect = 6e-07
Identities = 62/239 (25%), Positives = 108/239 (45%), Gaps = 39/239 (16%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E++++ AE + + ++ QR +EE+ R +A + K+ +EE +
Sbjct: 1370 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ----QQKRSIQEELQQL 1425
Query: 292 EAEKKAKAEAKRKEQEAKEKQR---QAELEAARLAKEKEEE-----EVRQQALLAK-KEK 342
+A+ +AK ++ EA E+ R + E+ RL E E E QAL A+ +E
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1485
Query: 343 DIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSC 402
+ QK+ ++E ++LR + +E++R K EVE L S
Sbjct: 1486 EAQKRQAQEEAERLRRQVQ-------DESQR-KRQAEVE-----------------LASR 1520
Query: 403 TKEVGKAALEKQ-IEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQ 460
K +AA EKQ + E++R + EEAE R+RQA + ++ +E +LQ
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1579
Score = 48.9 bits (115), Expect = 1e-05
Identities = 53/220 (24%), Positives = 103/220 (46%), Gaps = 28/220 (12%)
Query: 233 EEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKE 292
EE E+A + ER A +++R+ EE R++ + R + EK +KE
Sbjct: 2091 EEAEEARVQAER-------EAAQSRRQVEEAERLKQSAEE--QAQARAQAQAAAEKLRKE 2141
Query: 293 AEKKAKAEAKRKEQEAKEKQ-RQAELEAARLAKE---KEEEEVRQQAL---LAKKEKDIQ 345
AE++A A+ ++ ++KQ AE+E + E +++ +V Q+ L +E D Q
Sbjct: 2142 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2201
Query: 346 KKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKE 405
K + +E Q+L+ EA R + E E R+++ L L + + +
Sbjct: 2202 KNLLDEELQRLKAEA--------TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2253
Query: 406 V---GKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
+ K ++ ++E E++++ EEA AR+ A++ +
Sbjct: 2254 LILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSVAAQEAAR 2292
Score = 45.8 bits (107), Expect = 1e-04
Identities = 64/245 (26%), Positives = 106/245 (43%), Gaps = 44/245 (17%)
Query: 232 EEEKEKAECRDERRW----------------IEKQNR---ATRAQRKKEEMNRIRTLVDN 272
E++KE+AE RR +EKQ + T QR E IR +
Sbjct: 1663 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1722
Query: 273 AYSCDPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVR 332
R + EEE A+ + E A A KR+E EA+ + +AE+E +K + EEE R
Sbjct: 1723 EQGEQQR--QLLEEELARLQREAAA-ATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 333 QQALLAKK-------------EKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERV----- 374
+ +K+ E+ + +A+ +E ++ R + EAERV
Sbjct: 1780 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Query: 375 KMMEEVEKLCDRLELA--SLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEAR 432
+ E +L E+A + NE L ++ +A +++EE Q + + EE A+
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAED--EAFQRRRLEEQAAQHKADIEERLAQ 1897
Query: 433 MRQAS 437
+R+AS
Sbjct: 1898 LRKAS 1902
Score = 45.4 bits (106), Expect = 2e-04
Identities = 49/207 (23%), Positives = 97/207 (46%), Gaps = 21/207 (10%)
Query: 239 ECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAK 298
E +R E++ A Q+K++E+ + TL D + + E +A + A ++A+
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQ--TLQQEQSVLD----QLRGEAEAARRAAEEAE 2094
Query: 299 AEAKRKEQEAKEKQRQAELEAARL---AKEKEEEEVRQQALLAKKEKDIQKKAIKKERQK 355
+ E+EA + +RQ E EA RL A+E+ + + QA K K+ +++A + R +
Sbjct: 2095 EARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR--RAQ 2151
Query: 356 LRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAALEKQI 415
+ +D E E+ K E L + + LT+ ++ + +K +
Sbjct: 2152 AEQAALRQKQAADAEMEKHKKFAE-------QTLRQKAQVEQELTTLRLQLEETDHQKNL 2204
Query: 416 EEINEQIRKEKEEAEARMRQASKNTEK 442
++E++++ K EA RQ S+ E+
Sbjct: 2205 --LDEELQRLKAEATEAARQRSQVEEE 2229
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/275 (20%), Positives = 124/275 (45%), Gaps = 28/275 (10%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEA 293
E +A+ R E + Q +A+ E+++R + ++ +++ E
Sbjct: 2391 EMSRAQARAEE---DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2447
Query: 294 EKKAKAEAKRK----EQEAKEKQ-RQAELEAARLAKEKEEEEVRQQALLAKKEKDIQK-K 347
++A AE +R+ +QEAK Q + E++ + + +E + QQ+ L++K+ +Q+ +
Sbjct: 2448 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2507
Query: 348 AIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTK--- 404
I++E+ KL F D A+ ++ EE ++ ++E Q L ++ +
Sbjct: 2508 FIEQEKAKLEQL------FQDEVAKAQQLREEQQRQQQQME-QERQRLVASMEEARRRQH 2560
Query: 405 --EVGKAALEKQIEEINEQIRKEKE---EAEARMRQASKNTEKSTGGGGNGSKNWSEDDL 459
E G +++++++ +Q R+++E E R+R+ + E+ + SE+
Sbjct: 2561 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ----HRAALAHSEEVT 2616
Query: 460 QLLIKAVNLFPAGTNSRWEVIANYMNIHSSSGVKR 494
+ A P G ++ A HS G++R
Sbjct: 2617 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR 2651
Score = 42.0 bits (97), Expect = 0.002
Identities = 52/224 (23%), Positives = 107/224 (47%), Gaps = 23/224 (10%)
Query: 230 LDEE----EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKE 285
LDEE + E E +R +E++ + R Q EE+++++ ++ + R ++
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIE----AENRALILRD 2258
Query: 286 EEKAKKEAEKKAKAEAKRKEQEAKEKQRQ--AELEAARLAKEKEEEEVRQQALLAKKEKD 343
++ ++ ++ EA++ +Q A+E R A EAARL + EE+ +Q+AL K K
Sbjct: 2259 KDNTQRFLQE----EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK- 2313
Query: 344 IQKKAIKKERQKLRNSCKTWNHFSDNEAERV-KMMEEVEKLCDRL--ELASLQCLNETLT 400
+K +E +L+ + + E+ ++ E+ E++ +L E Q E
Sbjct: 2314 -EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2372
Query: 401 SCTKEVGKAA--LEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
E+ A L+ ++ E++ + +E+A+ +QA + EK
Sbjct: 2373 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2416
Score = 33.9 bits (76), Expect = 0.46
Identities = 50/215 (23%), Positives = 86/215 (40%), Gaps = 27/215 (12%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCD---------PRIKK 282
E+ K++ E + R+ E A R + EE R R L + + ++
Sbjct: 1783 EKSKQRLEA-EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841
Query: 283 FKEEEKAKKEAE-----KKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALL 337
E + K EAE K+A+ E R+ E + QR+ E A K EE + Q
Sbjct: 1842 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901
Query: 338 AKKEKDIQK----KAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQ 393
+ E + QK +++ RQ F A + ++ E+ ++ E
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE----- 1956
Query: 394 CLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEE 428
+TL S + +AA ++Q+ E+ R+E EE
Sbjct: 1957 ---DTLRSKEQAELEAARQRQLAAEEERRRREAEE 1988
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 61.6 bits (148), Expect = 2e-09
Identities = 87/394 (22%), Positives = 172/394 (43%), Gaps = 71/394 (18%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQR--KKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E+ + +E R + Q AT QR + E+ +R + +E E K+
Sbjct: 1412 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA-------------RAEEAEAQKR 1458
Query: 292 EAEKKAKAEAKRKEQEAKEKQRQAELE-AARLAKEKEEEEVRQQALLAKKEKDIQKKAIK 350
+A+++A+ +R+ Q+ +++RQAE+E A+R+ E E +Q+AL A +E +Q +
Sbjct: 1459 QAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ---AE 1514
Query: 351 KERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAA 410
+ ++LR + E ER + ++ + R A LQ + T A
Sbjct: 1515 EAERRLRQA----------EVERARQVQVALETAQRSAEAELQSKRASFAEKT-----AQ 1559
Query: 411 LEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNLFP 470
LE+ ++E + + + +EEAE R +Q ++ ++ +E +L+
Sbjct: 1560 LERSLQEEHVAVAQLREEAERRAQQQAE---------AERAREEAERELE---------- 1600
Query: 471 AGTNSRWEVIANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKKAFDKFKKEHG 530
RW++ AN + ++ A++V + Q QK++ ++A + K E
Sbjct: 1601 -----RWQLKAN-----EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1650
Query: 531 VVPQADNATPSERFEGPYTDFTPWTTEEQKLLEQALKTYPVNTP--ERWEKIAEAVPGRT 588
V Q + A E+ T +++ EQ L T E+ ++ E R
Sbjct: 1651 AVRQRELA---EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1707
Query: 589 KKD--CMKRYKELVEMVKAKKAAQEQVLNASRAK 620
+++ + ++ +E AK A+ +VL AS+A+
Sbjct: 1708 QREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1741
Score = 57.8 bits (138), Expect = 3e-08
Identities = 74/300 (24%), Positives = 129/300 (43%), Gaps = 37/300 (12%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E +E+AE R+ RW K N A R + + EE+ + ++L E EK K+
Sbjct: 1589 ERAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQ------------AEAEKQKE 1635
Query: 292 EAEKKAKAEAKRKEQEAK---------EKQRQAELEAARLAKEKEEEEVRQQALLAKKEK 342
EAE++A+ K +EQ + EKQRQ A+ E+E +R +A + E+
Sbjct: 1636 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1695
Query: 343 DIQKKAIKKERQKL-RNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTS 401
Q++ +++E +L R + + EAE K+ E+E L LAS E S
Sbjct: 1696 --QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL-----LASKARAEEESRS 1748
Query: 402 CTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQL 461
T E K LE + +E E AR+R ++ ++ + + ++
Sbjct: 1749 -TSEKSKQRLEAEAGRF-----RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1802
Query: 462 LIKAVNLFPAGTNSRWEV-IANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKK 520
L + + T + E IA + ++R A+D + + L++ K DI ++
Sbjct: 1803 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1862
Score = 54.3 bits (129), Expect = 3e-07
Identities = 51/214 (23%), Positives = 99/214 (46%), Gaps = 21/214 (9%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK 284
+E + L+ + + +ERR E + R ++ +EE R R A R+K
Sbjct: 1930 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA---ALEEVERLKAKV 1986
Query: 285 EEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDI 344
EE + +E ++ A + QEA +K+ QAE +A A +++E+E++Q ++E+ +
Sbjct: 1987 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ---TLQQEQSV 2043
Query: 345 QKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTK 404
+ ++ E + R + + EAE ++ E E R ++ + L ++
Sbjct: 2044 LDQ-LRGEAEAARRAAE--------EAEEARVQAEREAAQSRRQVEEAERLKQSAEE--- 2091
Query: 405 EVGKAALEKQIEEINEQIRKEKEEAEARMRQASK 438
+A Q + E++RKE E+ AR QA +
Sbjct: 2092 ---QAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2122
Score = 53.9 bits (128), Expect = 4e-07
Identities = 49/172 (28%), Positives = 85/172 (49%), Gaps = 15/172 (8%)
Query: 277 DPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQR-QAELEAARLAKEKEEEEVRQQA 335
+ R+ + + E+ ++ AE +A E +R+ EA + + QAE EA L + +EE VR++
Sbjct: 1315 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1374
Query: 336 LLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAE-----RVKMMEEVEKLCDRLELA 390
A + QK++I++E Q+LR S + +AE R+++ EE+ + +LE
Sbjct: 1375 --AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1432
Query: 391 SLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
Q E AL + EE Q R+ +EEAE RQ +++
Sbjct: 1433 ERQ-------RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1477
Score = 53.5 bits (127), Expect = 6e-07
Identities = 62/239 (25%), Positives = 108/239 (45%), Gaps = 39/239 (16%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E++++ AE + + ++ QR +EE+ R +A + K+ +EE +
Sbjct: 1338 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ----QQKRSIQEELQQL 1393
Query: 292 EAEKKAKAEAKRKEQEAKEKQR---QAELEAARLAKEKEEE-----EVRQQALLAK-KEK 342
+A+ +AK ++ EA E+ R + E+ RL E E E QAL A+ +E
Sbjct: 1394 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1453
Query: 343 DIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSC 402
+ QK+ ++E ++LR + +E++R K EVE L S
Sbjct: 1454 EAQKRQAQEEAERLRRQVQ-------DESQR-KRQAEVE-----------------LASR 1488
Query: 403 TKEVGKAALEKQ-IEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQ 460
K +AA EKQ + E++R + EEAE R+RQA + ++ +E +LQ
Sbjct: 1489 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1547
Score = 48.9 bits (115), Expect = 1e-05
Identities = 53/220 (24%), Positives = 103/220 (46%), Gaps = 28/220 (12%)
Query: 233 EEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKE 292
EE E+A + ER A +++R+ EE R++ + R + EK +KE
Sbjct: 2059 EEAEEARVQAER-------EAAQSRRQVEEAERLKQSAEE--QAQARAQAQAAAEKLRKE 2109
Query: 293 AEKKAKAEAKRKEQEAKEKQ-RQAELEAARLAKE---KEEEEVRQQAL---LAKKEKDIQ 345
AE++A A+ ++ ++KQ AE+E + E +++ +V Q+ L +E D Q
Sbjct: 2110 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2169
Query: 346 KKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKE 405
K + +E Q+L+ EA R + E E R+++ L L + + +
Sbjct: 2170 KNLLDEELQRLKAEA--------TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2221
Query: 406 V---GKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
+ K ++ ++E E++++ EEA AR+ A++ +
Sbjct: 2222 LILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSVAAQEAAR 2260
Score = 45.8 bits (107), Expect = 1e-04
Identities = 64/245 (26%), Positives = 106/245 (43%), Gaps = 44/245 (17%)
Query: 232 EEEKEKAECRDERRW----------------IEKQNR---ATRAQRKKEEMNRIRTLVDN 272
E++KE+AE RR +EKQ + T QR E IR +
Sbjct: 1631 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1690
Query: 273 AYSCDPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVR 332
R + EEE A+ + E A A KR+E EA+ + +AE+E +K + EEE R
Sbjct: 1691 EQGEQQR--QLLEEELARLQREAAA-ATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1747
Query: 333 QQALLAKK-------------EKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERV----- 374
+ +K+ E+ + +A+ +E ++ R + EAERV
Sbjct: 1748 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1807
Query: 375 KMMEEVEKLCDRLELA--SLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEAR 432
+ E +L E+A + NE L ++ +A +++EE Q + + EE A+
Sbjct: 1808 AAIGEATRLKTEAEIALKEKEAENERLRRLAED--EAFQRRRLEEQAAQHKADIEERLAQ 1865
Query: 433 MRQAS 437
+R+AS
Sbjct: 1866 LRKAS 1870
Score = 45.4 bits (106), Expect = 2e-04
Identities = 49/207 (23%), Positives = 97/207 (46%), Gaps = 21/207 (10%)
Query: 239 ECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAK 298
E +R E++ A Q+K++E+ + TL D + + E +A + A ++A+
Sbjct: 2009 EAAQKRLQAEEKAHAFAVQQKEQELQQ--TLQQEQSVLD----QLRGEAEAARRAAEEAE 2062
Query: 299 AEAKRKEQEAKEKQRQAELEAARL---AKEKEEEEVRQQALLAKKEKDIQKKAIKKERQK 355
+ E+EA + +RQ E EA RL A+E+ + + QA K K+ +++A + R +
Sbjct: 2063 EARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR--RAQ 2119
Query: 356 LRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAALEKQI 415
+ +D E E+ K E L + + LT+ ++ + +K +
Sbjct: 2120 AEQAALRQKQAADAEMEKHKKFAE-------QTLRQKAQVEQELTTLRLQLEETDHQKNL 2172
Query: 416 EEINEQIRKEKEEAEARMRQASKNTEK 442
++E++++ K EA RQ S+ E+
Sbjct: 2173 --LDEELQRLKAEATEAARQRSQVEEE 2197
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/275 (20%), Positives = 124/275 (45%), Gaps = 28/275 (10%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEA 293
E +A+ R E + Q +A+ E+++R + ++ +++ E
Sbjct: 2359 EMSRAQARAEE---DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2415
Query: 294 EKKAKAEAKRK----EQEAKEKQ-RQAELEAARLAKEKEEEEVRQQALLAKKEKDIQK-K 347
++A AE +R+ +QEAK Q + E++ + + +E + QQ+ L++K+ +Q+ +
Sbjct: 2416 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2475
Query: 348 AIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTK--- 404
I++E+ KL F D A+ ++ EE ++ ++E Q L ++ +
Sbjct: 2476 FIEQEKAKLEQL------FQDEVAKAQQLREEQQRQQQQME-QERQRLVASMEEARRRQH 2528
Query: 405 --EVGKAALEKQIEEINEQIRKEKE---EAEARMRQASKNTEKSTGGGGNGSKNWSEDDL 459
E G +++++++ +Q R+++E E R+R+ + E+ + SE+
Sbjct: 2529 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ----HRAALAHSEEVT 2584
Query: 460 QLLIKAVNLFPAGTNSRWEVIANYMNIHSSSGVKR 494
+ A P G ++ A HS G++R
Sbjct: 2585 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR 2619
Score = 42.0 bits (97), Expect = 0.002
Identities = 52/224 (23%), Positives = 107/224 (47%), Gaps = 23/224 (10%)
Query: 230 LDEE----EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKE 285
LDEE + E E +R +E++ + R Q EE+++++ ++ + R ++
Sbjct: 2173 LDEELQRLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIE----AENRALILRD 2226
Query: 286 EEKAKKEAEKKAKAEAKRKEQEAKEKQRQ--AELEAARLAKEKEEEEVRQQALLAKKEKD 343
++ ++ ++ EA++ +Q A+E R A EAARL + EE+ +Q+AL K K
Sbjct: 2227 KDNTQRFLQE----EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK- 2281
Query: 344 IQKKAIKKERQKLRNSCKTWNHFSDNEAERV-KMMEEVEKLCDRL--ELASLQCLNETLT 400
+K +E +L+ + + E+ ++ E+ E++ +L E Q E
Sbjct: 2282 -EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2340
Query: 401 SCTKEVGKAA--LEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
E+ A L+ ++ E++ + +E+A+ +QA + EK
Sbjct: 2341 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2384
Score = 33.9 bits (76), Expect = 0.46
Identities = 50/215 (23%), Positives = 86/215 (40%), Gaps = 27/215 (12%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCD---------PRIKK 282
E+ K++ E + R+ E A R + EE R R L + + ++
Sbjct: 1751 EKSKQRLEA-EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1809
Query: 283 FKEEEKAKKEAE-----KKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALL 337
E + K EAE K+A+ E R+ E + QR+ E A K EE + Q
Sbjct: 1810 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1869
Query: 338 AKKEKDIQK----KAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQ 393
+ E + QK +++ RQ F A + ++ E+ ++ E
Sbjct: 1870 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE----- 1924
Query: 394 CLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEE 428
+TL S + +AA ++Q+ E+ R+E EE
Sbjct: 1925 ---DTLRSKEQAELEAARQRQLAAEEERRRREAEE 1956
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 61.6 bits (148), Expect = 2e-09
Identities = 87/394 (22%), Positives = 172/394 (43%), Gaps = 71/394 (18%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQR--KKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E+ + +E R + Q AT QR + E+ +R + +E E K+
Sbjct: 1581 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA-------------RAEEAEAQKR 1627
Query: 292 EAEKKAKAEAKRKEQEAKEKQRQAELE-AARLAKEKEEEEVRQQALLAKKEKDIQKKAIK 350
+A+++A+ +R+ Q+ +++RQAE+E A+R+ E E +Q+AL A +E +Q +
Sbjct: 1628 QAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ---AE 1683
Query: 351 KERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAA 410
+ ++LR + E ER + ++ + R A LQ + T A
Sbjct: 1684 EAERRLRQA----------EVERARQVQVALETAQRSAEAELQSKRASFAEKT-----AQ 1728
Query: 411 LEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNLFP 470
LE+ ++E + + + +EEAE R +Q ++ ++ +E +L+
Sbjct: 1729 LERSLQEEHVAVAQLREEAERRAQQQAE---------AERAREEAERELE---------- 1769
Query: 471 AGTNSRWEVIANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKKAFDKFKKEHG 530
RW++ AN + ++ A++V + Q QK++ ++A + K E
Sbjct: 1770 -----RWQLKAN-----EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1819
Query: 531 VVPQADNATPSERFEGPYTDFTPWTTEEQKLLEQALKTYPVNTP--ERWEKIAEAVPGRT 588
V Q + A E+ T +++ EQ L T E+ ++ E R
Sbjct: 1820 AVRQRELA---EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1876
Query: 589 KKD--CMKRYKELVEMVKAKKAAQEQVLNASRAK 620
+++ + ++ +E AK A+ +VL AS+A+
Sbjct: 1877 QREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1910
Score = 57.8 bits (138), Expect = 3e-08
Identities = 74/300 (24%), Positives = 129/300 (43%), Gaps = 37/300 (12%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E +E+AE R+ RW K N A R + + EE+ + ++L E EK K+
Sbjct: 1758 ERAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQ------------AEAEKQKE 1804
Query: 292 EAEKKAKAEAKRKEQEAK---------EKQRQAELEAARLAKEKEEEEVRQQALLAKKEK 342
EAE++A+ K +EQ + EKQRQ A+ E+E +R +A + E+
Sbjct: 1805 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1864
Query: 343 DIQKKAIKKERQKL-RNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTS 401
Q++ +++E +L R + + EAE K+ E+E L LAS E S
Sbjct: 1865 --QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL-----LASKARAEEESRS 1917
Query: 402 CTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQL 461
T E K LE + +E E AR+R ++ ++ + + ++
Sbjct: 1918 -TSEKSKQRLEAEAGRF-----RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1971
Query: 462 LIKAVNLFPAGTNSRWEV-IANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKK 520
L + + T + E IA + ++R A+D + + L++ K DI ++
Sbjct: 1972 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 2031
Score = 54.3 bits (129), Expect = 3e-07
Identities = 51/214 (23%), Positives = 99/214 (46%), Gaps = 21/214 (9%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK 284
+E + L+ + + +ERR E + R ++ +EE R R A R+K
Sbjct: 2099 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA---ALEEVERLKAKV 2155
Query: 285 EEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDI 344
EE + +E ++ A + QEA +K+ QAE +A A +++E+E++Q ++E+ +
Sbjct: 2156 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ---TLQQEQSV 2212
Query: 345 QKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTK 404
+ ++ E + R + + EAE ++ E E R ++ + L ++
Sbjct: 2213 LDQ-LRGEAEAARRAAE--------EAEEARVQAEREAAQSRRQVEEAERLKQSAEE--- 2260
Query: 405 EVGKAALEKQIEEINEQIRKEKEEAEARMRQASK 438
+A Q + E++RKE E+ AR QA +
Sbjct: 2261 ---QAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2291
Score = 53.9 bits (128), Expect = 4e-07
Identities = 49/172 (28%), Positives = 85/172 (49%), Gaps = 15/172 (8%)
Query: 277 DPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQR-QAELEAARLAKEKEEEEVRQQA 335
+ R+ + + E+ ++ AE +A E +R+ EA + + QAE EA L + +EE VR++
Sbjct: 1484 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1543
Query: 336 LLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAE-----RVKMMEEVEKLCDRLELA 390
A + QK++I++E Q+LR S + +AE R+++ EE+ + +LE
Sbjct: 1544 --AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1601
Query: 391 SLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
Q E AL + EE Q R+ +EEAE RQ +++
Sbjct: 1602 ERQ-------RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646
Score = 53.5 bits (127), Expect = 6e-07
Identities = 62/239 (25%), Positives = 108/239 (45%), Gaps = 39/239 (16%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E++++ AE + + ++ QR +EE+ R +A + K+ +EE +
Sbjct: 1507 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ----QQKRSIQEELQQL 1562
Query: 292 EAEKKAKAEAKRKEQEAKEKQR---QAELEAARLAKEKEEE-----EVRQQALLAK-KEK 342
+A+ +AK ++ EA E+ R + E+ RL E E E QAL A+ +E
Sbjct: 1563 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1622
Query: 343 DIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSC 402
+ QK+ ++E ++LR + +E++R K EVE L S
Sbjct: 1623 EAQKRQAQEEAERLRRQVQ-------DESQR-KRQAEVE-----------------LASR 1657
Query: 403 TKEVGKAALEKQ-IEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQ 460
K +AA EKQ + E++R + EEAE R+RQA + ++ +E +LQ
Sbjct: 1658 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1716
Score = 48.9 bits (115), Expect = 1e-05
Identities = 53/220 (24%), Positives = 103/220 (46%), Gaps = 28/220 (12%)
Query: 233 EEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKE 292
EE E+A + ER A +++R+ EE R++ + R + EK +KE
Sbjct: 2228 EEAEEARVQAER-------EAAQSRRQVEEAERLKQSAEE--QAQARAQAQAAAEKLRKE 2278
Query: 293 AEKKAKAEAKRKEQEAKEKQ-RQAELEAARLAKE---KEEEEVRQQAL---LAKKEKDIQ 345
AE++A A+ ++ ++KQ AE+E + E +++ +V Q+ L +E D Q
Sbjct: 2279 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2338
Query: 346 KKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKE 405
K + +E Q+L+ EA R + E E R+++ L L + + +
Sbjct: 2339 KNLLDEELQRLKAEA--------TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2390
Query: 406 V---GKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
+ K ++ ++E E++++ EEA AR+ A++ +
Sbjct: 2391 LILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSVAAQEAAR 2429
Score = 45.8 bits (107), Expect = 1e-04
Identities = 64/245 (26%), Positives = 106/245 (43%), Gaps = 44/245 (17%)
Query: 232 EEEKEKAECRDERRW----------------IEKQNR---ATRAQRKKEEMNRIRTLVDN 272
E++KE+AE RR +EKQ + T QR E IR +
Sbjct: 1800 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1859
Query: 273 AYSCDPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVR 332
R + EEE A+ + E A A KR+E EA+ + +AE+E +K + EEE R
Sbjct: 1860 EQGEQQR--QLLEEELARLQREAAA-ATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916
Query: 333 QQALLAKK-------------EKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERV----- 374
+ +K+ E+ + +A+ +E ++ R + EAERV
Sbjct: 1917 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1976
Query: 375 KMMEEVEKLCDRLELA--SLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEAR 432
+ E +L E+A + NE L ++ +A +++EE Q + + EE A+
Sbjct: 1977 AAIGEATRLKTEAEIALKEKEAENERLRRLAED--EAFQRRRLEEQAAQHKADIEERLAQ 2034
Query: 433 MRQAS 437
+R+AS
Sbjct: 2035 LRKAS 2039
Score = 45.4 bits (106), Expect = 2e-04
Identities = 49/207 (23%), Positives = 97/207 (46%), Gaps = 21/207 (10%)
Query: 239 ECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAK 298
E +R E++ A Q+K++E+ + TL D + + E +A + A ++A+
Sbjct: 2178 EAAQKRLQAEEKAHAFAVQQKEQELQQ--TLQQEQSVLD----QLRGEAEAARRAAEEAE 2231
Query: 299 AEAKRKEQEAKEKQRQAELEAARL---AKEKEEEEVRQQALLAKKEKDIQKKAIKKERQK 355
+ E+EA + +RQ E EA RL A+E+ + + QA K K+ +++A + R +
Sbjct: 2232 EARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR--RAQ 2288
Query: 356 LRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAALEKQI 415
+ +D E E+ K E L + + LT+ ++ + +K +
Sbjct: 2289 AEQAALRQKQAADAEMEKHKKFAE-------QTLRQKAQVEQELTTLRLQLEETDHQKNL 2341
Query: 416 EEINEQIRKEKEEAEARMRQASKNTEK 442
++E++++ K EA RQ S+ E+
Sbjct: 2342 --LDEELQRLKAEATEAARQRSQVEEE 2366
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/275 (20%), Positives = 124/275 (45%), Gaps = 28/275 (10%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEA 293
E +A+ R E + Q +A+ E+++R + ++ +++ E
Sbjct: 2528 EMSRAQARAEE---DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2584
Query: 294 EKKAKAEAKRK----EQEAKEKQ-RQAELEAARLAKEKEEEEVRQQALLAKKEKDIQK-K 347
++A AE +R+ +QEAK Q + E++ + + +E + QQ+ L++K+ +Q+ +
Sbjct: 2585 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2644
Query: 348 AIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTK--- 404
I++E+ KL F D A+ ++ EE ++ ++E Q L ++ +
Sbjct: 2645 FIEQEKAKLEQL------FQDEVAKAQQLREEQQRQQQQME-QERQRLVASMEEARRRQH 2697
Query: 405 --EVGKAALEKQIEEINEQIRKEKE---EAEARMRQASKNTEKSTGGGGNGSKNWSEDDL 459
E G +++++++ +Q R+++E E R+R+ + E+ + SE+
Sbjct: 2698 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ----HRAALAHSEEVT 2753
Query: 460 QLLIKAVNLFPAGTNSRWEVIANYMNIHSSSGVKR 494
+ A P G ++ A HS G++R
Sbjct: 2754 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR 2788
Score = 42.0 bits (97), Expect = 0.002
Identities = 52/224 (23%), Positives = 107/224 (47%), Gaps = 23/224 (10%)
Query: 230 LDEE----EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKE 285
LDEE + E E +R +E++ + R Q EE+++++ ++ + R ++
Sbjct: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIE----AENRALILRD 2395
Query: 286 EEKAKKEAEKKAKAEAKRKEQEAKEKQRQ--AELEAARLAKEKEEEEVRQQALLAKKEKD 343
++ ++ ++ EA++ +Q A+E R A EAARL + EE+ +Q+AL K K
Sbjct: 2396 KDNTQRFLQE----EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK- 2450
Query: 344 IQKKAIKKERQKLRNSCKTWNHFSDNEAERV-KMMEEVEKLCDRL--ELASLQCLNETLT 400
+K +E +L+ + + E+ ++ E+ E++ +L E Q E
Sbjct: 2451 -EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2509
Query: 401 SCTKEVGKAA--LEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
E+ A L+ ++ E++ + +E+A+ +QA + EK
Sbjct: 2510 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2553
Score = 33.9 bits (76), Expect = 0.46
Identities = 50/215 (23%), Positives = 86/215 (40%), Gaps = 27/215 (12%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCD---------PRIKK 282
E+ K++ E + R+ E A R + EE R R L + + ++
Sbjct: 1920 EKSKQRLEA-EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1978
Query: 283 FKEEEKAKKEAE-----KKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALL 337
E + K EAE K+A+ E R+ E + QR+ E A K EE + Q
Sbjct: 1979 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 2038
Query: 338 AKKEKDIQK----KAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQ 393
+ E + QK +++ RQ F A + ++ E+ ++ E
Sbjct: 2039 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE----- 2093
Query: 394 CLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEE 428
+TL S + +AA ++Q+ E+ R+E EE
Sbjct: 2094 ---DTLRSKEQAELEAARQRQLAAEEERRRREAEE 2125
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 61.6 bits (148), Expect = 2e-09
Identities = 87/394 (22%), Positives = 172/394 (43%), Gaps = 71/394 (18%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQR--KKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E+ + +E R + Q AT QR + E+ +R + +E E K+
Sbjct: 1422 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA-------------RAEEAEAQKR 1468
Query: 292 EAEKKAKAEAKRKEQEAKEKQRQAELE-AARLAKEKEEEEVRQQALLAKKEKDIQKKAIK 350
+A+++A+ +R+ Q+ +++RQAE+E A+R+ E E +Q+AL A +E +Q +
Sbjct: 1469 QAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ---AE 1524
Query: 351 KERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAA 410
+ ++LR + E ER + ++ + R A LQ + T A
Sbjct: 1525 EAERRLRQA----------EVERARQVQVALETAQRSAEAELQSKRASFAEKT-----AQ 1569
Query: 411 LEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNLFP 470
LE+ ++E + + + +EEAE R +Q ++ ++ +E +L+
Sbjct: 1570 LERSLQEEHVAVAQLREEAERRAQQQAE---------AERAREEAERELE---------- 1610
Query: 471 AGTNSRWEVIANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKKAFDKFKKEHG 530
RW++ AN + ++ A++V + Q QK++ ++A + K E
Sbjct: 1611 -----RWQLKAN-----EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1660
Query: 531 VVPQADNATPSERFEGPYTDFTPWTTEEQKLLEQALKTYPVNTP--ERWEKIAEAVPGRT 588
V Q + A E+ T +++ EQ L T E+ ++ E R
Sbjct: 1661 AVRQRELA---EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1717
Query: 589 KKD--CMKRYKELVEMVKAKKAAQEQVLNASRAK 620
+++ + ++ +E AK A+ +VL AS+A+
Sbjct: 1718 QREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1751
Score = 57.8 bits (138), Expect = 3e-08
Identities = 74/300 (24%), Positives = 129/300 (43%), Gaps = 37/300 (12%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E +E+AE R+ RW K N A R + + EE+ + ++L E EK K+
Sbjct: 1599 ERAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQ------------AEAEKQKE 1645
Query: 292 EAEKKAKAEAKRKEQEAK---------EKQRQAELEAARLAKEKEEEEVRQQALLAKKEK 342
EAE++A+ K +EQ + EKQRQ A+ E+E +R +A + E+
Sbjct: 1646 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1705
Query: 343 DIQKKAIKKERQKL-RNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTS 401
Q++ +++E +L R + + EAE K+ E+E L LAS E S
Sbjct: 1706 --QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL-----LASKARAEEESRS 1758
Query: 402 CTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQL 461
T E K LE + +E E AR+R ++ ++ + + ++
Sbjct: 1759 -TSEKSKQRLEAEAGRF-----RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1812
Query: 462 LIKAVNLFPAGTNSRWEV-IANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKK 520
L + + T + E IA + ++R A+D + + L++ K DI ++
Sbjct: 1813 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1872
Score = 54.3 bits (129), Expect = 3e-07
Identities = 51/214 (23%), Positives = 99/214 (46%), Gaps = 21/214 (9%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK 284
+E + L+ + + +ERR E + R ++ +EE R R A R+K
Sbjct: 1940 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA---ALEEVERLKAKV 1996
Query: 285 EEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDI 344
EE + +E ++ A + QEA +K+ QAE +A A +++E+E++Q ++E+ +
Sbjct: 1997 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ---TLQQEQSV 2053
Query: 345 QKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTK 404
+ ++ E + R + + EAE ++ E E R ++ + L ++
Sbjct: 2054 LDQ-LRGEAEAARRAAE--------EAEEARVQAEREAAQSRRQVEEAERLKQSAEE--- 2101
Query: 405 EVGKAALEKQIEEINEQIRKEKEEAEARMRQASK 438
+A Q + E++RKE E+ AR QA +
Sbjct: 2102 ---QAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2132
Score = 53.9 bits (128), Expect = 4e-07
Identities = 49/172 (28%), Positives = 85/172 (49%), Gaps = 15/172 (8%)
Query: 277 DPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQR-QAELEAARLAKEKEEEEVRQQA 335
+ R+ + + E+ ++ AE +A E +R+ EA + + QAE EA L + +EE VR++
Sbjct: 1325 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1384
Query: 336 LLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAE-----RVKMMEEVEKLCDRLELA 390
A + QK++I++E Q+LR S + +AE R+++ EE+ + +LE
Sbjct: 1385 --AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1442
Query: 391 SLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
Q E AL + EE Q R+ +EEAE RQ +++
Sbjct: 1443 ERQ-------RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1487
Score = 53.5 bits (127), Expect = 6e-07
Identities = 62/239 (25%), Positives = 108/239 (45%), Gaps = 39/239 (16%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E++++ AE + + ++ QR +EE+ R +A + K+ +EE +
Sbjct: 1348 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ----QQKRSIQEELQQL 1403
Query: 292 EAEKKAKAEAKRKEQEAKEKQR---QAELEAARLAKEKEEE-----EVRQQALLAK-KEK 342
+A+ +AK ++ EA E+ R + E+ RL E E E QAL A+ +E
Sbjct: 1404 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1463
Query: 343 DIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSC 402
+ QK+ ++E ++LR + +E++R K EVE L S
Sbjct: 1464 EAQKRQAQEEAERLRRQVQ-------DESQR-KRQAEVE-----------------LASR 1498
Query: 403 TKEVGKAALEKQ-IEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQ 460
K +AA EKQ + E++R + EEAE R+RQA + ++ +E +LQ
Sbjct: 1499 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1557
Score = 48.9 bits (115), Expect = 1e-05
Identities = 53/220 (24%), Positives = 103/220 (46%), Gaps = 28/220 (12%)
Query: 233 EEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKE 292
EE E+A + ER A +++R+ EE R++ + R + EK +KE
Sbjct: 2069 EEAEEARVQAER-------EAAQSRRQVEEAERLKQSAEE--QAQARAQAQAAAEKLRKE 2119
Query: 293 AEKKAKAEAKRKEQEAKEKQ-RQAELEAARLAKE---KEEEEVRQQAL---LAKKEKDIQ 345
AE++A A+ ++ ++KQ AE+E + E +++ +V Q+ L +E D Q
Sbjct: 2120 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2179
Query: 346 KKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKE 405
K + +E Q+L+ EA R + E E R+++ L L + + +
Sbjct: 2180 KNLLDEELQRLKAEA--------TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2231
Query: 406 V---GKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
+ K ++ ++E E++++ EEA AR+ A++ +
Sbjct: 2232 LILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSVAAQEAAR 2270
Score = 45.8 bits (107), Expect = 1e-04
Identities = 64/245 (26%), Positives = 106/245 (43%), Gaps = 44/245 (17%)
Query: 232 EEEKEKAECRDERRW----------------IEKQNR---ATRAQRKKEEMNRIRTLVDN 272
E++KE+AE RR +EKQ + T QR E IR +
Sbjct: 1641 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1700
Query: 273 AYSCDPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVR 332
R + EEE A+ + E A A KR+E EA+ + +AE+E +K + EEE R
Sbjct: 1701 EQGEQQR--QLLEEELARLQREAAA-ATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757
Query: 333 QQALLAKK-------------EKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERV----- 374
+ +K+ E+ + +A+ +E ++ R + EAERV
Sbjct: 1758 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1817
Query: 375 KMMEEVEKLCDRLELA--SLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEAR 432
+ E +L E+A + NE L ++ +A +++EE Q + + EE A+
Sbjct: 1818 AAIGEATRLKTEAEIALKEKEAENERLRRLAED--EAFQRRRLEEQAAQHKADIEERLAQ 1875
Query: 433 MRQAS 437
+R+AS
Sbjct: 1876 LRKAS 1880
Score = 45.4 bits (106), Expect = 2e-04
Identities = 49/207 (23%), Positives = 97/207 (46%), Gaps = 21/207 (10%)
Query: 239 ECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAK 298
E +R E++ A Q+K++E+ + TL D + + E +A + A ++A+
Sbjct: 2019 EAAQKRLQAEEKAHAFAVQQKEQELQQ--TLQQEQSVLD----QLRGEAEAARRAAEEAE 2072
Query: 299 AEAKRKEQEAKEKQRQAELEAARL---AKEKEEEEVRQQALLAKKEKDIQKKAIKKERQK 355
+ E+EA + +RQ E EA RL A+E+ + + QA K K+ +++A + R +
Sbjct: 2073 EARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR--RAQ 2129
Query: 356 LRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAALEKQI 415
+ +D E E+ K E L + + LT+ ++ + +K +
Sbjct: 2130 AEQAALRQKQAADAEMEKHKKFAE-------QTLRQKAQVEQELTTLRLQLEETDHQKNL 2182
Query: 416 EEINEQIRKEKEEAEARMRQASKNTEK 442
++E++++ K EA RQ S+ E+
Sbjct: 2183 --LDEELQRLKAEATEAARQRSQVEEE 2207
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/275 (20%), Positives = 124/275 (45%), Gaps = 28/275 (10%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEA 293
E +A+ R E + Q +A+ E+++R + ++ +++ E
Sbjct: 2369 EMSRAQARAEE---DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2425
Query: 294 EKKAKAEAKRK----EQEAKEKQ-RQAELEAARLAKEKEEEEVRQQALLAKKEKDIQK-K 347
++A AE +R+ +QEAK Q + E++ + + +E + QQ+ L++K+ +Q+ +
Sbjct: 2426 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2485
Query: 348 AIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTK--- 404
I++E+ KL F D A+ ++ EE ++ ++E Q L ++ +
Sbjct: 2486 FIEQEKAKLEQL------FQDEVAKAQQLREEQQRQQQQME-QERQRLVASMEEARRRQH 2538
Query: 405 --EVGKAALEKQIEEINEQIRKEKE---EAEARMRQASKNTEKSTGGGGNGSKNWSEDDL 459
E G +++++++ +Q R+++E E R+R+ + E+ + SE+
Sbjct: 2539 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ----HRAALAHSEEVT 2594
Query: 460 QLLIKAVNLFPAGTNSRWEVIANYMNIHSSSGVKR 494
+ A P G ++ A HS G++R
Sbjct: 2595 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR 2629
Score = 42.0 bits (97), Expect = 0.002
Identities = 52/224 (23%), Positives = 107/224 (47%), Gaps = 23/224 (10%)
Query: 230 LDEE----EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKE 285
LDEE + E E +R +E++ + R Q EE+++++ ++ + R ++
Sbjct: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIE----AENRALILRD 2236
Query: 286 EEKAKKEAEKKAKAEAKRKEQEAKEKQRQ--AELEAARLAKEKEEEEVRQQALLAKKEKD 343
++ ++ ++ EA++ +Q A+E R A EAARL + EE+ +Q+AL K K
Sbjct: 2237 KDNTQRFLQE----EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK- 2291
Query: 344 IQKKAIKKERQKLRNSCKTWNHFSDNEAERV-KMMEEVEKLCDRL--ELASLQCLNETLT 400
+K +E +L+ + + E+ ++ E+ E++ +L E Q E
Sbjct: 2292 -EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2350
Query: 401 SCTKEVGKAA--LEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
E+ A L+ ++ E++ + +E+A+ +QA + EK
Sbjct: 2351 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2394
Score = 33.9 bits (76), Expect = 0.46
Identities = 50/215 (23%), Positives = 86/215 (40%), Gaps = 27/215 (12%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCD---------PRIKK 282
E+ K++ E + R+ E A R + EE R R L + + ++
Sbjct: 1761 EKSKQRLEA-EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1819
Query: 283 FKEEEKAKKEAE-----KKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALL 337
E + K EAE K+A+ E R+ E + QR+ E A K EE + Q
Sbjct: 1820 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1879
Query: 338 AKKEKDIQK----KAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQ 393
+ E + QK +++ RQ F A + ++ E+ ++ E
Sbjct: 1880 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE----- 1934
Query: 394 CLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEE 428
+TL S + +AA ++Q+ E+ R+E EE
Sbjct: 1935 ---DTLRSKEQAELEAARQRQLAAEEERRRREAEE 1966
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 61.6 bits (148), Expect = 2e-09
Identities = 87/394 (22%), Positives = 172/394 (43%), Gaps = 71/394 (18%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQR--KKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E+ + +E R + Q AT QR + E+ +R + +E E K+
Sbjct: 1430 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA-------------RAEEAEAQKR 1476
Query: 292 EAEKKAKAEAKRKEQEAKEKQRQAELE-AARLAKEKEEEEVRQQALLAKKEKDIQKKAIK 350
+A+++A+ +R+ Q+ +++RQAE+E A+R+ E E +Q+AL A +E +Q +
Sbjct: 1477 QAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ---AE 1532
Query: 351 KERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAA 410
+ ++LR + E ER + ++ + R A LQ + T A
Sbjct: 1533 EAERRLRQA----------EVERARQVQVALETAQRSAEAELQSKRASFAEKT-----AQ 1577
Query: 411 LEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNLFP 470
LE+ ++E + + + +EEAE R +Q ++ ++ +E +L+
Sbjct: 1578 LERSLQEEHVAVAQLREEAERRAQQQAE---------AERAREEAERELE---------- 1618
Query: 471 AGTNSRWEVIANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKKAFDKFKKEHG 530
RW++ AN + ++ A++V + Q QK++ ++A + K E
Sbjct: 1619 -----RWQLKAN-----EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1668
Query: 531 VVPQADNATPSERFEGPYTDFTPWTTEEQKLLEQALKTYPVNTP--ERWEKIAEAVPGRT 588
V Q + A E+ T +++ EQ L T E+ ++ E R
Sbjct: 1669 AVRQRELA---EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1725
Query: 589 KKD--CMKRYKELVEMVKAKKAAQEQVLNASRAK 620
+++ + ++ +E AK A+ +VL AS+A+
Sbjct: 1726 QREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1759
Score = 57.8 bits (138), Expect = 3e-08
Identities = 74/300 (24%), Positives = 129/300 (43%), Gaps = 37/300 (12%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E +E+AE R+ RW K N A R + + EE+ + ++L E EK K+
Sbjct: 1607 ERAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQ------------AEAEKQKE 1653
Query: 292 EAEKKAKAEAKRKEQEAK---------EKQRQAELEAARLAKEKEEEEVRQQALLAKKEK 342
EAE++A+ K +EQ + EKQRQ A+ E+E +R +A + E+
Sbjct: 1654 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1713
Query: 343 DIQKKAIKKERQKL-RNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTS 401
Q++ +++E +L R + + EAE K+ E+E L LAS E S
Sbjct: 1714 --QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL-----LASKARAEEESRS 1766
Query: 402 CTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQL 461
T E K LE + +E E AR+R ++ ++ + + ++
Sbjct: 1767 -TSEKSKQRLEAEAGRF-----RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1820
Query: 462 LIKAVNLFPAGTNSRWEV-IANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKK 520
L + + T + E IA + ++R A+D + + L++ K DI ++
Sbjct: 1821 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1880
Score = 54.3 bits (129), Expect = 3e-07
Identities = 51/214 (23%), Positives = 99/214 (46%), Gaps = 21/214 (9%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK 284
+E + L+ + + +ERR E + R ++ +EE R R A R+K
Sbjct: 1948 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA---ALEEVERLKAKV 2004
Query: 285 EEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDI 344
EE + +E ++ A + QEA +K+ QAE +A A +++E+E++Q ++E+ +
Sbjct: 2005 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ---TLQQEQSV 2061
Query: 345 QKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTK 404
+ ++ E + R + + EAE ++ E E R ++ + L ++
Sbjct: 2062 LDQ-LRGEAEAARRAAE--------EAEEARVQAEREAAQSRRQVEEAERLKQSAEE--- 2109
Query: 405 EVGKAALEKQIEEINEQIRKEKEEAEARMRQASK 438
+A Q + E++RKE E+ AR QA +
Sbjct: 2110 ---QAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2140
Score = 53.9 bits (128), Expect = 4e-07
Identities = 49/172 (28%), Positives = 85/172 (49%), Gaps = 15/172 (8%)
Query: 277 DPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQR-QAELEAARLAKEKEEEEVRQQA 335
+ R+ + + E+ ++ AE +A E +R+ EA + + QAE EA L + +EE VR++
Sbjct: 1333 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1392
Query: 336 LLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAE-----RVKMMEEVEKLCDRLELA 390
A + QK++I++E Q+LR S + +AE R+++ EE+ + +LE
Sbjct: 1393 --AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1450
Query: 391 SLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
Q E AL + EE Q R+ +EEAE RQ +++
Sbjct: 1451 ERQ-------RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1495
Score = 53.5 bits (127), Expect = 6e-07
Identities = 62/239 (25%), Positives = 108/239 (45%), Gaps = 39/239 (16%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E++++ AE + + ++ QR +EE+ R +A + K+ +EE +
Sbjct: 1356 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ----QQKRSIQEELQQL 1411
Query: 292 EAEKKAKAEAKRKEQEAKEKQR---QAELEAARLAKEKEEE-----EVRQQALLAK-KEK 342
+A+ +AK ++ EA E+ R + E+ RL E E E QAL A+ +E
Sbjct: 1412 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1471
Query: 343 DIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSC 402
+ QK+ ++E ++LR + +E++R K EVE L S
Sbjct: 1472 EAQKRQAQEEAERLRRQVQ-------DESQR-KRQAEVE-----------------LASR 1506
Query: 403 TKEVGKAALEKQ-IEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQ 460
K +AA EKQ + E++R + EEAE R+RQA + ++ +E +LQ
Sbjct: 1507 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1565
Score = 48.9 bits (115), Expect = 1e-05
Identities = 53/220 (24%), Positives = 103/220 (46%), Gaps = 28/220 (12%)
Query: 233 EEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKE 292
EE E+A + ER A +++R+ EE R++ + R + EK +KE
Sbjct: 2077 EEAEEARVQAER-------EAAQSRRQVEEAERLKQSAEE--QAQARAQAQAAAEKLRKE 2127
Query: 293 AEKKAKAEAKRKEQEAKEKQ-RQAELEAARLAKE---KEEEEVRQQAL---LAKKEKDIQ 345
AE++A A+ ++ ++KQ AE+E + E +++ +V Q+ L +E D Q
Sbjct: 2128 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2187
Query: 346 KKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKE 405
K + +E Q+L+ EA R + E E R+++ L L + + +
Sbjct: 2188 KNLLDEELQRLKAEA--------TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2239
Query: 406 V---GKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
+ K ++ ++E E++++ EEA AR+ A++ +
Sbjct: 2240 LILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSVAAQEAAR 2278
Score = 45.8 bits (107), Expect = 1e-04
Identities = 64/245 (26%), Positives = 106/245 (43%), Gaps = 44/245 (17%)
Query: 232 EEEKEKAECRDERRW----------------IEKQNR---ATRAQRKKEEMNRIRTLVDN 272
E++KE+AE RR +EKQ + T QR E IR +
Sbjct: 1649 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1708
Query: 273 AYSCDPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVR 332
R + EEE A+ + E A A KR+E EA+ + +AE+E +K + EEE R
Sbjct: 1709 EQGEQQR--QLLEEELARLQREAAA-ATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1765
Query: 333 QQALLAKK-------------EKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERV----- 374
+ +K+ E+ + +A+ +E ++ R + EAERV
Sbjct: 1766 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1825
Query: 375 KMMEEVEKLCDRLELA--SLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEAR 432
+ E +L E+A + NE L ++ +A +++EE Q + + EE A+
Sbjct: 1826 AAIGEATRLKTEAEIALKEKEAENERLRRLAED--EAFQRRRLEEQAAQHKADIEERLAQ 1883
Query: 433 MRQAS 437
+R+AS
Sbjct: 1884 LRKAS 1888
Score = 45.4 bits (106), Expect = 2e-04
Identities = 49/207 (23%), Positives = 97/207 (46%), Gaps = 21/207 (10%)
Query: 239 ECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAK 298
E +R E++ A Q+K++E+ + TL D + + E +A + A ++A+
Sbjct: 2027 EAAQKRLQAEEKAHAFAVQQKEQELQQ--TLQQEQSVLD----QLRGEAEAARRAAEEAE 2080
Query: 299 AEAKRKEQEAKEKQRQAELEAARL---AKEKEEEEVRQQALLAKKEKDIQKKAIKKERQK 355
+ E+EA + +RQ E EA RL A+E+ + + QA K K+ +++A + R +
Sbjct: 2081 EARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR--RAQ 2137
Query: 356 LRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAALEKQI 415
+ +D E E+ K E L + + LT+ ++ + +K +
Sbjct: 2138 AEQAALRQKQAADAEMEKHKKFAE-------QTLRQKAQVEQELTTLRLQLEETDHQKNL 2190
Query: 416 EEINEQIRKEKEEAEARMRQASKNTEK 442
++E++++ K EA RQ S+ E+
Sbjct: 2191 --LDEELQRLKAEATEAARQRSQVEEE 2215
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/275 (20%), Positives = 124/275 (45%), Gaps = 28/275 (10%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEA 293
E +A+ R E + Q +A+ E+++R + ++ +++ E
Sbjct: 2377 EMSRAQARAEE---DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2433
Query: 294 EKKAKAEAKRK----EQEAKEKQ-RQAELEAARLAKEKEEEEVRQQALLAKKEKDIQK-K 347
++A AE +R+ +QEAK Q + E++ + + +E + QQ+ L++K+ +Q+ +
Sbjct: 2434 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2493
Query: 348 AIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTK--- 404
I++E+ KL F D A+ ++ EE ++ ++E Q L ++ +
Sbjct: 2494 FIEQEKAKLEQL------FQDEVAKAQQLREEQQRQQQQME-QERQRLVASMEEARRRQH 2546
Query: 405 --EVGKAALEKQIEEINEQIRKEKE---EAEARMRQASKNTEKSTGGGGNGSKNWSEDDL 459
E G +++++++ +Q R+++E E R+R+ + E+ + SE+
Sbjct: 2547 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ----HRAALAHSEEVT 2602
Query: 460 QLLIKAVNLFPAGTNSRWEVIANYMNIHSSSGVKR 494
+ A P G ++ A HS G++R
Sbjct: 2603 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR 2637
Score = 42.0 bits (97), Expect = 0.002
Identities = 52/224 (23%), Positives = 107/224 (47%), Gaps = 23/224 (10%)
Query: 230 LDEE----EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKE 285
LDEE + E E +R +E++ + R Q EE+++++ ++ + R ++
Sbjct: 2191 LDEELQRLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIE----AENRALILRD 2244
Query: 286 EEKAKKEAEKKAKAEAKRKEQEAKEKQRQ--AELEAARLAKEKEEEEVRQQALLAKKEKD 343
++ ++ ++ EA++ +Q A+E R A EAARL + EE+ +Q+AL K K
Sbjct: 2245 KDNTQRFLQE----EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK- 2299
Query: 344 IQKKAIKKERQKLRNSCKTWNHFSDNEAERV-KMMEEVEKLCDRL--ELASLQCLNETLT 400
+K +E +L+ + + E+ ++ E+ E++ +L E Q E
Sbjct: 2300 -EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2358
Query: 401 SCTKEVGKAA--LEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
E+ A L+ ++ E++ + +E+A+ +QA + EK
Sbjct: 2359 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2402
Score = 33.9 bits (76), Expect = 0.46
Identities = 50/215 (23%), Positives = 86/215 (40%), Gaps = 27/215 (12%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCD---------PRIKK 282
E+ K++ E + R+ E A R + EE R R L + + ++
Sbjct: 1769 EKSKQRLEA-EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1827
Query: 283 FKEEEKAKKEAE-----KKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALL 337
E + K EAE K+A+ E R+ E + QR+ E A K EE + Q
Sbjct: 1828 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1887
Query: 338 AKKEKDIQK----KAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQ 393
+ E + QK +++ RQ F A + ++ E+ ++ E
Sbjct: 1888 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE----- 1942
Query: 394 CLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEE 428
+TL S + +AA ++Q+ E+ R+E EE
Sbjct: 1943 ---DTLRSKEQAELEAARQRQLAAEEERRRREAEE 1974
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 61.6 bits (148), Expect = 2e-09
Identities = 87/394 (22%), Positives = 172/394 (43%), Gaps = 71/394 (18%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQR--KKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E+ + +E R + Q AT QR + E+ +R + +E E K+
Sbjct: 1471 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA-------------RAEEAEAQKR 1517
Query: 292 EAEKKAKAEAKRKEQEAKEKQRQAELE-AARLAKEKEEEEVRQQALLAKKEKDIQKKAIK 350
+A+++A+ +R+ Q+ +++RQAE+E A+R+ E E +Q+AL A +E +Q +
Sbjct: 1518 QAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ---AE 1573
Query: 351 KERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAA 410
+ ++LR + E ER + ++ + R A LQ + T A
Sbjct: 1574 EAERRLRQA----------EVERARQVQVALETAQRSAEAELQSKRASFAEKT-----AQ 1618
Query: 411 LEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNLFP 470
LE+ ++E + + + +EEAE R +Q ++ ++ +E +L+
Sbjct: 1619 LERSLQEEHVAVAQLREEAERRAQQQAE---------AERAREEAERELE---------- 1659
Query: 471 AGTNSRWEVIANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKKAFDKFKKEHG 530
RW++ AN + ++ A++V + Q QK++ ++A + K E
Sbjct: 1660 -----RWQLKAN-----EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1709
Query: 531 VVPQADNATPSERFEGPYTDFTPWTTEEQKLLEQALKTYPVNTP--ERWEKIAEAVPGRT 588
V Q + A E+ T +++ EQ L T E+ ++ E R
Sbjct: 1710 AVRQRELA---EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1766
Query: 589 KKD--CMKRYKELVEMVKAKKAAQEQVLNASRAK 620
+++ + ++ +E AK A+ +VL AS+A+
Sbjct: 1767 QREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1800
Score = 57.8 bits (138), Expect = 3e-08
Identities = 74/300 (24%), Positives = 129/300 (43%), Gaps = 37/300 (12%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E +E+AE R+ RW K N A R + + EE+ + ++L E EK K+
Sbjct: 1648 ERAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQ------------AEAEKQKE 1694
Query: 292 EAEKKAKAEAKRKEQEAK---------EKQRQAELEAARLAKEKEEEEVRQQALLAKKEK 342
EAE++A+ K +EQ + EKQRQ A+ E+E +R +A + E+
Sbjct: 1695 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1754
Query: 343 DIQKKAIKKERQKL-RNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTS 401
Q++ +++E +L R + + EAE K+ E+E L LAS E S
Sbjct: 1755 --QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL-----LASKARAEEESRS 1807
Query: 402 CTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQL 461
T E K LE + +E E AR+R ++ ++ + + ++
Sbjct: 1808 -TSEKSKQRLEAEAGRF-----RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1861
Query: 462 LIKAVNLFPAGTNSRWEV-IANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKK 520
L + + T + E IA + ++R A+D + + L++ K DI ++
Sbjct: 1862 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1921
Score = 54.3 bits (129), Expect = 3e-07
Identities = 51/214 (23%), Positives = 99/214 (46%), Gaps = 21/214 (9%)
Query: 225 REFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK 284
+E + L+ + + +ERR E + R ++ +EE R R A R+K
Sbjct: 1989 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA---ALEEVERLKAKV 2045
Query: 285 EEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDI 344
EE + +E ++ A + QEA +K+ QAE +A A +++E+E++Q ++E+ +
Sbjct: 2046 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ---TLQQEQSV 2102
Query: 345 QKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTK 404
+ ++ E + R + + EAE ++ E E R ++ + L ++
Sbjct: 2103 LDQ-LRGEAEAARRAAE--------EAEEARVQAEREAAQSRRQVEEAERLKQSAEE--- 2150
Query: 405 EVGKAALEKQIEEINEQIRKEKEEAEARMRQASK 438
+A Q + E++RKE E+ AR QA +
Sbjct: 2151 ---QAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2181
Score = 53.9 bits (128), Expect = 4e-07
Identities = 49/172 (28%), Positives = 85/172 (49%), Gaps = 15/172 (8%)
Query: 277 DPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQR-QAELEAARLAKEKEEEEVRQQA 335
+ R+ + + E+ ++ AE +A E +R+ EA + + QAE EA L + +EE VR++
Sbjct: 1374 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1433
Query: 336 LLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAE-----RVKMMEEVEKLCDRLELA 390
A + QK++I++E Q+LR S + +AE R+++ EE+ + +LE
Sbjct: 1434 --AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1491
Query: 391 SLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
Q E AL + EE Q R+ +EEAE RQ +++
Sbjct: 1492 ERQ-------RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1536
Score = 53.5 bits (127), Expect = 6e-07
Identities = 62/239 (25%), Positives = 108/239 (45%), Gaps = 39/239 (16%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
E++++ AE + + ++ QR +EE+ R +A + K+ +EE +
Sbjct: 1397 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ----QQKRSIQEELQQL 1452
Query: 292 EAEKKAKAEAKRKEQEAKEKQR---QAELEAARLAKEKEEE-----EVRQQALLAK-KEK 342
+A+ +AK ++ EA E+ R + E+ RL E E E QAL A+ +E
Sbjct: 1453 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1512
Query: 343 DIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSC 402
+ QK+ ++E ++LR + +E++R K EVE L S
Sbjct: 1513 EAQKRQAQEEAERLRRQVQ-------DESQR-KRQAEVE-----------------LASR 1547
Query: 403 TKEVGKAALEKQ-IEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQ 460
K +AA EKQ + E++R + EEAE R+RQA + ++ +E +LQ
Sbjct: 1548 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1606
Score = 48.9 bits (115), Expect = 1e-05
Identities = 53/220 (24%), Positives = 103/220 (46%), Gaps = 28/220 (12%)
Query: 233 EEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKE 292
EE E+A + ER A +++R+ EE R++ + R + EK +KE
Sbjct: 2118 EEAEEARVQAER-------EAAQSRRQVEEAERLKQSAEE--QAQARAQAQAAAEKLRKE 2168
Query: 293 AEKKAKAEAKRKEQEAKEKQ-RQAELEAARLAKE---KEEEEVRQQAL---LAKKEKDIQ 345
AE++A A+ ++ ++KQ AE+E + E +++ +V Q+ L +E D Q
Sbjct: 2169 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ 2228
Query: 346 KKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKE 405
K + +E Q+L+ EA R + E E R+++ L L + + +
Sbjct: 2229 KNLLDEELQRLKAEA--------TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2280
Query: 406 V---GKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
+ K ++ ++E E++++ EEA AR+ A++ +
Sbjct: 2281 LILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSVAAQEAAR 2319
Score = 45.8 bits (107), Expect = 1e-04
Identities = 64/245 (26%), Positives = 106/245 (43%), Gaps = 44/245 (17%)
Query: 232 EEEKEKAECRDERRW----------------IEKQNR---ATRAQRKKEEMNRIRTLVDN 272
E++KE+AE RR +EKQ + T QR E IR +
Sbjct: 1690 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1749
Query: 273 AYSCDPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVR 332
R + EEE A+ + E A A KR+E EA+ + +AE+E +K + EEE R
Sbjct: 1750 EQGEQQR--QLLEEELARLQREAAA-ATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806
Query: 333 QQALLAKK-------------EKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERV----- 374
+ +K+ E+ + +A+ +E ++ R + EAERV
Sbjct: 1807 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1866
Query: 375 KMMEEVEKLCDRLELA--SLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEAR 432
+ E +L E+A + NE L ++ +A +++EE Q + + EE A+
Sbjct: 1867 AAIGEATRLKTEAEIALKEKEAENERLRRLAED--EAFQRRRLEEQAAQHKADIEERLAQ 1924
Query: 433 MRQAS 437
+R+AS
Sbjct: 1925 LRKAS 1929
Score = 45.4 bits (106), Expect = 2e-04
Identities = 49/207 (23%), Positives = 97/207 (46%), Gaps = 21/207 (10%)
Query: 239 ECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAK 298
E +R E++ A Q+K++E+ + TL D + + E +A + A ++A+
Sbjct: 2068 EAAQKRLQAEEKAHAFAVQQKEQELQQ--TLQQEQSVLD----QLRGEAEAARRAAEEAE 2121
Query: 299 AEAKRKEQEAKEKQRQAELEAARL---AKEKEEEEVRQQALLAKKEKDIQKKAIKKERQK 355
+ E+EA + +RQ E EA RL A+E+ + + QA K K+ +++A + R +
Sbjct: 2122 EARVQAEREAAQSRRQVE-EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR--RAQ 2178
Query: 356 LRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAALEKQI 415
+ +D E E+ K E L + + LT+ ++ + +K +
Sbjct: 2179 AEQAALRQKQAADAEMEKHKKFAE-------QTLRQKAQVEQELTTLRLQLEETDHQKNL 2231
Query: 416 EEINEQIRKEKEEAEARMRQASKNTEK 442
++E++++ K EA RQ S+ E+
Sbjct: 2232 --LDEELQRLKAEATEAARQRSQVEEE 2256
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/275 (20%), Positives = 124/275 (45%), Gaps = 28/275 (10%)
Query: 234 EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEA 293
E +A+ R E + Q +A+ E+++R + ++ +++ E
Sbjct: 2418 EMSRAQARAEE---DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2474
Query: 294 EKKAKAEAKRK----EQEAKEKQ-RQAELEAARLAKEKEEEEVRQQALLAKKEKDIQK-K 347
++A AE +R+ +QEAK Q + E++ + + +E + QQ+ L++K+ +Q+ +
Sbjct: 2475 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2534
Query: 348 AIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTK--- 404
I++E+ KL F D A+ ++ EE ++ ++E Q L ++ +
Sbjct: 2535 FIEQEKAKLEQL------FQDEVAKAQQLREEQQRQQQQME-QERQRLVASMEEARRRQH 2587
Query: 405 --EVGKAALEKQIEEINEQIRKEKE---EAEARMRQASKNTEKSTGGGGNGSKNWSEDDL 459
E G +++++++ +Q R+++E E R+R+ + E+ + SE+
Sbjct: 2588 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ----HRAALAHSEEVT 2643
Query: 460 QLLIKAVNLFPAGTNSRWEVIANYMNIHSSSGVKR 494
+ A P G ++ A HS G++R
Sbjct: 2644 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR 2678
Score = 42.0 bits (97), Expect = 0.002
Identities = 52/224 (23%), Positives = 107/224 (47%), Gaps = 23/224 (10%)
Query: 230 LDEE----EKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKE 285
LDEE + E E +R +E++ + R Q EE+++++ ++ + R ++
Sbjct: 2232 LDEELQRLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIE----AENRALILRD 2285
Query: 286 EEKAKKEAEKKAKAEAKRKEQEAKEKQRQ--AELEAARLAKEKEEEEVRQQALLAKKEKD 343
++ ++ ++ EA++ +Q A+E R A EAARL + EE+ +Q+AL K K
Sbjct: 2286 KDNTQRFLQE----EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK- 2340
Query: 344 IQKKAIKKERQKLRNSCKTWNHFSDNEAERV-KMMEEVEKLCDRL--ELASLQCLNETLT 400
+K +E +L+ + + E+ ++ E+ E++ +L E Q E
Sbjct: 2341 -EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2399
Query: 401 SCTKEVGKAA--LEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
E+ A L+ ++ E++ + +E+A+ +QA + EK
Sbjct: 2400 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2443
Score = 33.9 bits (76), Expect = 0.46
Identities = 50/215 (23%), Positives = 86/215 (40%), Gaps = 27/215 (12%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCD---------PRIKK 282
E+ K++ E + R+ E A R + EE R R L + + ++
Sbjct: 1810 EKSKQRLEA-EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1868
Query: 283 FKEEEKAKKEAE-----KKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALL 337
E + K EAE K+A+ E R+ E + QR+ E A K EE + Q
Sbjct: 1869 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1928
Query: 338 AKKEKDIQK----KAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQ 393
+ E + QK +++ RQ F A + ++ E+ ++ E
Sbjct: 1929 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE----- 1983
Query: 394 CLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEE 428
+TL S + +AA ++Q+ E+ R+E EE
Sbjct: 1984 ---DTLRSKEQAELEAARQRQLAAEEERRRREAEE 2015
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 61.2 bits (147), Expect = 3e-09
Identities = 92/390 (23%), Positives = 167/390 (42%), Gaps = 58/390 (14%)
Query: 230 LDEEEKEKAECRDE-RRWIEKQNRATRAQRK--KEEMNRIRTLVDNAYSCDPRIKKFKEE 286
L E EKEK E +D+ RR IE + +K N ++ + A + E
Sbjct: 1008 LMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTA------LSNE 1061
Query: 287 EKAKKEAEKKAKAEAKRKEQEAKEKQ-RQAELEAARLAKEKEEE--EVRQ---------- 333
++A+++ +++AK + + + +E A++EA + AKE+ + VRQ
Sbjct: 1062 QQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAE 1121
Query: 334 -QALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASL 392
Q L K + +++ +K E K C+ D E + + +++EKL D++ +
Sbjct: 1122 SQLLECKASWEERERMLKDEVSKCVCRCE------DLEKQNRLLHDQIEKLSDKVVASVK 1175
Query: 393 QCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSK 452
+ + L E GK+ ++QI EI IR+EKE AE R A + +
Sbjct: 1176 EGVQGPLNVSLSEEGKS--QEQILEILRFIRREKEIAETRFEVAQVESLRY-----RQRV 1228
Query: 453 NWSEDDLQLLIKAVNLFPAGTNSRWEVIANYMNIHSSSGVKRTAKDVIGKA-KSLQKLDP 511
E +LQ L ++N + +V A M H K +V+ + K L++
Sbjct: 1229 ELLERELQELQDSLN----AEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
Query: 512 HQKDDINKKAFDKFKKEHGVVP-QADNATPSERFEGPYTDFTPWTTEEQKLLEQALKTYP 570
+ D+ + K E ++P Q NA SE+ + E+KLLE+ +K
Sbjct: 1285 RLEQDLQQMQAKVRKLELDILPLQEANAELSEK--------SGMLQAEKKLLEEDVK--- 1333
Query: 571 VNTPERWEKIAEAVPGRTKKDCMKRYKELV 600
RW+ + + + K + Y++L+
Sbjct: 1334 -----RWKARNQHLVSQQKDPDTEEYRKLL 1358
Score = 37.7 bits (86), Expect = 0.032
Identities = 80/401 (19%), Positives = 158/401 (39%), Gaps = 56/401 (13%)
Query: 230 LDEEEKEKAECRDERRWIEKQNRATRAQR--KKEEMNR--IRTLVDNAYSCDPRIKKFKE 285
L +KE A + +E Q + +QR K + N+ + LV + ++ KE
Sbjct: 894 LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKE 953
Query: 286 EEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQ 345
K ++ +A E E+ K++Q E + + + +E Q L KK +++
Sbjct: 954 RLKTSTSNVEQYQAMVTSLE-ESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
Query: 346 KKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKE 405
K E+Q+L+ D++ ++ ME+ L L +TL+S E
Sbjct: 1013 K-----EKQELQ----------DDKRRAIESMEQ-----------QLSELKKTLSSVQNE 1046
Query: 406 VGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKA 465
V +A NEQ + + +A++ ++N E +L L
Sbjct: 1047 VQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKY--------------ERELMLHAAD 1092
Query: 466 VNLFPAGTNSRWEVIANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINK---KAF 522
V A ++ + + H ++ ++ S ++ + KD+++K +
Sbjct: 1093 VEALQAAKEQVSKMAS--VRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCE 1150
Query: 523 DKFKKE---HGVVPQADNATPSERFEGPYTDFTPWTTEEQKLLEQALKTYPVNTPERWEK 579
D K+ H + + + + EG +EE K EQ L+ + R ++
Sbjct: 1151 DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEI--LRFIRREKE 1208
Query: 580 IAEAVPGRTKKDCMKRYKELVEMVKAKKAAQEQVLNASRAK 620
IAE + + + RY++ VE+++ + + LNA R K
Sbjct: 1209 IAETRFEVAQVESL-RYRQRVELLERELQELQDSLNAEREK 1248
Score = 32.3 bits (72), Expect = 1.3
Identities = 42/197 (21%), Positives = 87/197 (44%), Gaps = 34/197 (17%)
Query: 280 IKKFKEEEKAKKEAEKKAKA----------EAKRKEQEAKEKQRQA---ELEAARLAKE- 325
+++ +E ++ +AE K+K+ KE EA+ Q Q + E +RL ++
Sbjct: 1473 VQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDL 1532
Query: 326 ----KEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVE 381
+EE++RQQ + K+EK +KAI + K+ + + + E + ++
Sbjct: 1533 QDRTTQEEQLRQQ-ITEKEEK--TRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALD 1589
Query: 382 KLCDRLELASLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAE-------ARMR 434
+ D L+ + T E + LE+++ E E+ ++++E + + R
Sbjct: 1590 QQKDELD------VRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQR 1643
Query: 435 QASKNTEKSTGGGGNGS 451
Q + T ++G G S
Sbjct: 1644 QITLKTTPASGERGIAS 1660
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 60.8 bits (146), Expect = 4e-09
Identities = 53/204 (25%), Positives = 101/204 (49%), Gaps = 27/204 (13%)
Query: 233 EEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKE 292
E+ + A+ ERR E + + +RK++E R + + +++ +EEE+ ++E
Sbjct: 724 EKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQ--------EEILRRQQEEERKRRE 775
Query: 293 AEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQ--ALLAKKEKDIQKKAIK 350
E+ A+ RK++EA +QR+ E+ L +++EEEE +QQ AL +E+ +++ +
Sbjct: 776 EEELAR----RKQEEALRRQREQEIA---LRRQREEEERQQQEEALRRLEERRREEEERR 828
Query: 351 KERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAA 410
K+ + LR E E K E E+ RLE L+ E +E +
Sbjct: 829 KQEELLRK----------QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKR 878
Query: 411 LEKQIEEINEQIRKEKEEAEARMR 434
E +++ E +R+ +++ EA R
Sbjct: 879 KELEVQRQKELMRQRQQQQEALRR 902
Score = 57.8 bits (138), Expect = 3e-08
Identities = 53/242 (21%), Positives = 113/242 (46%), Gaps = 40/242 (16%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
++E+E+ +E KQ A R QR++E R + + + +++ +E + ++
Sbjct: 766 QQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEE 825
Query: 292 EAEKKAKAEAKRKEQEAK-------------EKQRQAELEAARLAKEKEEEEVRQQALLA 338
E K+ + K++E+ AK E + + E EAARL E+EE +
Sbjct: 826 ERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERK-------- 877
Query: 339 KKEKDIQK-KAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCD-RLELASLQCLN 396
+KE ++Q+ K + ++RQ+ + + + R++ ++ ++L +L +S
Sbjct: 878 RKELEVQRQKELMRQRQQQQEALR-----------RLQQQQQQQQLAQMKLPSSSTWGQQ 926
Query: 397 ETLTSCTKE--VGKAALEKQIEE----INEQIRKEKEEAEARMRQASKNTEKSTGGGGNG 450
T+C + + A ++K EE + E+ R+++ E ++Q + ++ G GN
Sbjct: 927 SNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNV 986
Query: 451 SK 452
SK
Sbjct: 987 SK 988
Score = 46.2 bits (108), Expect = 9e-05
Identities = 42/169 (24%), Positives = 81/169 (47%), Gaps = 9/169 (5%)
Query: 278 PRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALL 337
P +++ ++ EKAK AK E +R+E E + K+ + E + + ++EE +R+Q
Sbjct: 715 PALEQLQQLEKAKA-----AKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEE 769
Query: 338 AKKEKDIQKKAIKKERQKLRNSCKTWNHF--SDNEAERVKMMEEVEKLCD-RLELASLQC 394
+K ++ ++ A +K+ + LR + E ER + E + +L + R E +
Sbjct: 770 ERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRK 829
Query: 395 LNETLTSCTKEVGK-AALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
E L +E K A E++ + E+ R EE AR+R + ++
Sbjct: 830 QEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKR 878
Score = 42.4 bits (98), Expect = 0.001
Identities = 38/184 (20%), Positives = 76/184 (41%), Gaps = 37/184 (20%)
Query: 230 LDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK--EEE 287
L+E +E+ E R + + KQ A+ +EE R L +N + + + EEE
Sbjct: 817 LEERRREEEERRKQEELLRKQEEEA-AKWAREEEEAQRRLEENRLRMEEEAARLRHEEEE 875
Query: 288 KAKKEAEKKAKAEAKRKEQEAKEK---------------------------------QRQ 314
+ +KE E + + E R+ Q+ +E Q Q
Sbjct: 876 RKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQ 935
Query: 315 AELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERV 374
A L A + K +EE E + + ++++++ K A+++++Q+ + W + S
Sbjct: 936 ATLSLAEIQKLEEERERQLREEQRRQQRELMK-ALQQQQQQQQQKLSGWGNVSKPSGTTK 994
Query: 375 KMME 378
++E
Sbjct: 995 SLLE 998
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 60.8 bits (146), Expect = 4e-09
Identities = 53/204 (25%), Positives = 101/204 (49%), Gaps = 27/204 (13%)
Query: 233 EEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKE 292
E+ + A+ ERR E + + +RK++E R + + +++ +EEE+ ++E
Sbjct: 751 EKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQ--------EEILRRQQEEERKRRE 802
Query: 293 AEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQ--ALLAKKEKDIQKKAIK 350
E+ A+ RK++EA +QR+ E+ L +++EEEE +QQ AL +E+ +++ +
Sbjct: 803 EEELAR----RKQEEALRRQREQEIA---LRRQREEEERQQQEEALRRLEERRREEEERR 855
Query: 351 KERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAA 410
K+ + LR E E K E E+ RLE L+ E +E +
Sbjct: 856 KQEELLRK----------QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKR 905
Query: 411 LEKQIEEINEQIRKEKEEAEARMR 434
E +++ E +R+ +++ EA R
Sbjct: 906 KELEVQRQKELMRQRQQQQEALRR 929
Score = 57.8 bits (138), Expect = 3e-08
Identities = 53/242 (21%), Positives = 113/242 (46%), Gaps = 40/242 (16%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
++E+E+ +E KQ A R QR++E R + + + +++ +E + ++
Sbjct: 793 QQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEE 852
Query: 292 EAEKKAKAEAKRKEQEAK-------------EKQRQAELEAARLAKEKEEEEVRQQALLA 338
E K+ + K++E+ AK E + + E EAARL E+EE +
Sbjct: 853 ERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERK-------- 904
Query: 339 KKEKDIQK-KAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCD-RLELASLQCLN 396
+KE ++Q+ K + ++RQ+ + + + R++ ++ ++L +L +S
Sbjct: 905 RKELEVQRQKELMRQRQQQQEALR-----------RLQQQQQQQQLAQMKLPSSSTWGQQ 953
Query: 397 ETLTSCTKE--VGKAALEKQIEE----INEQIRKEKEEAEARMRQASKNTEKSTGGGGNG 450
T+C + + A ++K EE + E+ R+++ E ++Q + ++ G GN
Sbjct: 954 SNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNV 1013
Query: 451 SK 452
SK
Sbjct: 1014 SK 1015
Score = 46.2 bits (108), Expect = 9e-05
Identities = 42/169 (24%), Positives = 81/169 (47%), Gaps = 9/169 (5%)
Query: 278 PRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALL 337
P +++ ++ EKAK AK E +R+E E + K+ + E + + ++EE +R+Q
Sbjct: 742 PALEQLQQLEKAKA-----AKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEE 796
Query: 338 AKKEKDIQKKAIKKERQKLRNSCKTWNHF--SDNEAERVKMMEEVEKLCD-RLELASLQC 394
+K ++ ++ A +K+ + LR + E ER + E + +L + R E +
Sbjct: 797 ERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRK 856
Query: 395 LNETLTSCTKEVGK-AALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
E L +E K A E++ + E+ R EE AR+R + ++
Sbjct: 857 QEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKR 905
Score = 42.4 bits (98), Expect = 0.001
Identities = 38/184 (20%), Positives = 76/184 (41%), Gaps = 37/184 (20%)
Query: 230 LDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK--EEE 287
L+E +E+ E R + + KQ A+ +EE R L +N + + + EEE
Sbjct: 844 LEERRREEEERRKQEELLRKQEEEA-AKWAREEEEAQRRLEENRLRMEEEAARLRHEEEE 902
Query: 288 KAKKEAEKKAKAEAKRKEQEAKEK---------------------------------QRQ 314
+ +KE E + + E R+ Q+ +E Q Q
Sbjct: 903 RKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQ 962
Query: 315 AELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERV 374
A L A + K +EE E + + ++++++ K A+++++Q+ + W + S
Sbjct: 963 ATLSLAEIQKLEEERERQLREEQRRQQRELMK-ALQQQQQQQQQKLSGWGNVSKPSGTTK 1021
Query: 375 KMME 378
++E
Sbjct: 1022 SLLE 1025
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 60.8 bits (146), Expect = 4e-09
Identities = 53/204 (25%), Positives = 101/204 (49%), Gaps = 27/204 (13%)
Query: 233 EEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKE 292
E+ + A+ ERR E + + +RK++E R + + +++ +EEE+ ++E
Sbjct: 730 EKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQ--------EEILRRQQEEERKRRE 781
Query: 293 AEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQ--ALLAKKEKDIQKKAIK 350
E+ A+ RK++EA +QR+ E+ L +++EEEE +QQ AL +E+ +++ +
Sbjct: 782 EEELAR----RKQEEALRRQREQEIA---LRRQREEEERQQQEEALRRLEERRREEEERR 834
Query: 351 KERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAA 410
K+ + LR E E K E E+ RLE L+ E +E +
Sbjct: 835 KQEELLRK----------QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKR 884
Query: 411 LEKQIEEINEQIRKEKEEAEARMR 434
E +++ E +R+ +++ EA R
Sbjct: 885 KELEVQRQKELMRQRQQQQEALRR 908
Score = 57.8 bits (138), Expect = 3e-08
Identities = 53/242 (21%), Positives = 113/242 (46%), Gaps = 40/242 (16%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
++E+E+ +E KQ A R QR++E R + + + +++ +E + ++
Sbjct: 772 QQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEE 831
Query: 292 EAEKKAKAEAKRKEQEAK-------------EKQRQAELEAARLAKEKEEEEVRQQALLA 338
E K+ + K++E+ AK E + + E EAARL E+EE +
Sbjct: 832 ERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERK-------- 883
Query: 339 KKEKDIQK-KAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCD-RLELASLQCLN 396
+KE ++Q+ K + ++RQ+ + + + R++ ++ ++L +L +S
Sbjct: 884 RKELEVQRQKELMRQRQQQQEALR-----------RLQQQQQQQQLAQMKLPSSSTWGQQ 932
Query: 397 ETLTSCTKE--VGKAALEKQIEE----INEQIRKEKEEAEARMRQASKNTEKSTGGGGNG 450
T+C + + A ++K EE + E+ R+++ E ++Q + ++ G GN
Sbjct: 933 SNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNV 992
Query: 451 SK 452
SK
Sbjct: 993 SK 994
Score = 46.2 bits (108), Expect = 9e-05
Identities = 42/169 (24%), Positives = 81/169 (47%), Gaps = 9/169 (5%)
Query: 278 PRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALL 337
P +++ ++ EKAK AK E +R+E E + K+ + E + + ++EE +R+Q
Sbjct: 721 PALEQLQQLEKAKA-----AKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEE 775
Query: 338 AKKEKDIQKKAIKKERQKLRNSCKTWNHF--SDNEAERVKMMEEVEKLCD-RLELASLQC 394
+K ++ ++ A +K+ + LR + E ER + E + +L + R E +
Sbjct: 776 ERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRK 835
Query: 395 LNETLTSCTKEVGK-AALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
E L +E K A E++ + E+ R EE AR+R + ++
Sbjct: 836 QEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKR 884
Score = 42.4 bits (98), Expect = 0.001
Identities = 38/184 (20%), Positives = 76/184 (41%), Gaps = 37/184 (20%)
Query: 230 LDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK--EEE 287
L+E +E+ E R + + KQ A+ +EE R L +N + + + EEE
Sbjct: 823 LEERRREEEERRKQEELLRKQEEEA-AKWAREEEEAQRRLEENRLRMEEEAARLRHEEEE 881
Query: 288 KAKKEAEKKAKAEAKRKEQEAKEK---------------------------------QRQ 314
+ +KE E + + E R+ Q+ +E Q Q
Sbjct: 882 RKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQ 941
Query: 315 AELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERV 374
A L A + K +EE E + + ++++++ K A+++++Q+ + W + S
Sbjct: 942 ATLSLAEIQKLEEERERQLREEQRRQQRELMK-ALQQQQQQQQQKLSGWGNVSKPSGTTK 1000
Query: 375 KMME 378
++E
Sbjct: 1001 SLLE 1004
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 60.8 bits (146), Expect = 4e-09
Identities = 53/204 (25%), Positives = 101/204 (49%), Gaps = 27/204 (13%)
Query: 233 EEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKE 292
E+ + A+ ERR E + + +RK++E R + + +++ +EEE+ ++E
Sbjct: 730 EKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQ--------EEILRRQQEEERKRRE 781
Query: 293 AEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQ--ALLAKKEKDIQKKAIK 350
E+ A+ RK++EA +QR+ E+ L +++EEEE +QQ AL +E+ +++ +
Sbjct: 782 EEELAR----RKQEEALRRQREQEIA---LRRQREEEERQQQEEALRRLEERRREEEERR 834
Query: 351 KERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAA 410
K+ + LR E E K E E+ RLE L+ E +E +
Sbjct: 835 KQEELLRK----------QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKR 884
Query: 411 LEKQIEEINEQIRKEKEEAEARMR 434
E +++ E +R+ +++ EA R
Sbjct: 885 KELEVQRQKELMRQRQQQQEALRR 908
Score = 57.8 bits (138), Expect = 3e-08
Identities = 53/242 (21%), Positives = 113/242 (46%), Gaps = 40/242 (16%)
Query: 232 EEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKK 291
++E+E+ +E KQ A R QR++E R + + + +++ +E + ++
Sbjct: 772 QQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEE 831
Query: 292 EAEKKAKAEAKRKEQEAK-------------EKQRQAELEAARLAKEKEEEEVRQQALLA 338
E K+ + K++E+ AK E + + E EAARL E+EE +
Sbjct: 832 ERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERK-------- 883
Query: 339 KKEKDIQK-KAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCD-RLELASLQCLN 396
+KE ++Q+ K + ++RQ+ + + + R++ ++ ++L +L +S
Sbjct: 884 RKELEVQRQKELMRQRQQQQEALR-----------RLQQQQQQQQLAQMKLPSSSTWGQQ 932
Query: 397 ETLTSCTKE--VGKAALEKQIEE----INEQIRKEKEEAEARMRQASKNTEKSTGGGGNG 450
T+C + + A ++K EE + E+ R+++ E ++Q + ++ G GN
Sbjct: 933 SNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNV 992
Query: 451 SK 452
SK
Sbjct: 993 SK 994
Score = 46.2 bits (108), Expect = 9e-05
Identities = 42/169 (24%), Positives = 81/169 (47%), Gaps = 9/169 (5%)
Query: 278 PRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALL 337
P +++ ++ EKAK AK E +R+E E + K+ + E + + ++EE +R+Q
Sbjct: 721 PALEQLQQLEKAKA-----AKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEE 775
Query: 338 AKKEKDIQKKAIKKERQKLRNSCKTWNHF--SDNEAERVKMMEEVEKLCD-RLELASLQC 394
+K ++ ++ A +K+ + LR + E ER + E + +L + R E +
Sbjct: 776 ERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRK 835
Query: 395 LNETLTSCTKEVGK-AALEKQIEEINEQIRKEKEEAEARMRQASKNTEK 442
E L +E K A E++ + E+ R EE AR+R + ++
Sbjct: 836 QEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKR 884
Score = 42.4 bits (98), Expect = 0.001
Identities = 38/184 (20%), Positives = 76/184 (41%), Gaps = 37/184 (20%)
Query: 230 LDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFK--EEE 287
L+E +E+ E R + + KQ A+ +EE R L +N + + + EEE
Sbjct: 823 LEERRREEEERRKQEELLRKQEEEA-AKWAREEEEAQRRLEENRLRMEEEAARLRHEEEE 881
Query: 288 KAKKEAEKKAKAEAKRKEQEAKEK---------------------------------QRQ 314
+ +KE E + + E R+ Q+ +E Q Q
Sbjct: 882 RKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQ 941
Query: 315 AELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERV 374
A L A + K +EE E + + ++++++ K A+++++Q+ + W + S
Sbjct: 942 ATLSLAEIQKLEEERERQLREEQRRQQRELMK-ALQQQQQQQQQKLSGWGNVSKPSGTTK 1000
Query: 375 KMME 378
++E
Sbjct: 1001 SLLE 1004
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.126 0.357
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,741,245
Number of Sequences: 37866
Number of extensions: 1148307
Number of successful extensions: 27514
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 665
Number of HSP's successfully gapped in prelim test: 1145
Number of HSP's that attempted gapping in prelim test: 8077
Number of HSP's gapped (non-prelim): 9054
length of query: 621
length of database: 18,247,518
effective HSP length: 108
effective length of query: 513
effective length of database: 14,157,990
effective search space: 7263048870
effective search space used: 7263048870
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.