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Search of human proteins with 91825557
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|91825557 kinesin light chain 3 [Homo sapiens]
(504 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|91825557 kinesin light chain 3 [Homo sapiens] 986 0.0
gi|41871960 kinesin-like 8 isoform b [Homo sapiens] 520 e-147
gi|41871955 kinesin-like 8 isoform a [Homo sapiens] 520 e-147
gi|41871946 kinesin-like 8 isoform a [Homo sapiens] 520 e-147
gi|194306559 kinesin light chain 1 isoform 3 [Homo sapiens] 513 e-145
gi|110735431 kinesin light chain 1 isoform 2 [Homo sapiens] 513 e-145
gi|33620730 kinesin light chain 1 isoform 1 [Homo sapiens] 513 e-145
gi|198041734 kinesin light chain 2 isoform 1 [Homo sapiens] 506 e-143
gi|198041731 kinesin light chain 2 isoform 1 [Homo sapiens] 506 e-143
gi|12383062 kinesin light chain 2 isoform 1 [Homo sapiens] 506 e-143
gi|198041728 kinesin light chain 2 isoform 2 [Homo sapiens] 363 e-100
gi|19923891 kinesin-like 8 isoform c [Homo sapiens] 337 2e-92
gi|34304360 nephrocystin 3 [Homo sapiens] 136 5e-32
gi|87162455 hypothetical protein LOC23277 [Homo sapiens] 60 5e-09
gi|18104962 amyloid beta precursor protein-binding protein 2 [Ho... 57 4e-08
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 56 7e-08
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 56 7e-08
gi|22547159 tetratricopeptide repeat domain 19 [Homo sapiens] 54 3e-07
gi|22749211 transmembrane and tetratricopeptide repeat containin... 50 6e-06
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 49 1e-05
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 49 1e-05
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 49 1e-05
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 49 1e-05
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 49 1e-05
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 49 1e-05
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 49 1e-05
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 49 1e-05
gi|38045919 huntingtin interacting protein 1 [Homo sapiens] 49 1e-05
gi|81295809 pericentrin [Homo sapiens] 47 4e-05
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 47 5e-05
>gi|91825557 kinesin light chain 3 [Homo sapiens]
Length = 504
Score = 986 bits (2549), Expect = 0.0
Identities = 504/504 (100%), Positives = 504/504 (100%)
Query: 1 MSVQVAAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAG 60
MSVQVAAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAG
Sbjct: 1 MSVQVAAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAG 60
Query: 61 LEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLR 120
LEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLR
Sbjct: 61 LEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLR 120
Query: 121 EELEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPS 180
EELEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPS
Sbjct: 121 EELEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPS 180
Query: 181 EEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERS 240
EEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERS
Sbjct: 181 EEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERS 240
Query: 241 SGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVL 300
SGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVL
Sbjct: 241 SGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVL 300
Query: 301 YGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARAL 360
YGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARAL
Sbjct: 301 YGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARAL 360
Query: 361 SIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGAPNTGTAG 420
SIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGAPNTGTAG
Sbjct: 361 SIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGAPNTGTAG 420
Query: 421 DAEQALRRSSSLSKIRESIRRGSEKLVSRLRGEAAAGAAGMKRAMSLNTLNVDAPRAPGT 480
DAEQALRRSSSLSKIRESIRRGSEKLVSRLRGEAAAGAAGMKRAMSLNTLNVDAPRAPGT
Sbjct: 421 DAEQALRRSSSLSKIRESIRRGSEKLVSRLRGEAAAGAAGMKRAMSLNTLNVDAPRAPGT 480
Query: 481 QFPSWHLDKAPRTLSASTQDLSPH 504
QFPSWHLDKAPRTLSASTQDLSPH
Sbjct: 481 QFPSWHLDKAPRTLSASTQDLSPH 504
>gi|41871960 kinesin-like 8 isoform b [Homo sapiens]
Length = 637
Score = 520 bits (1338), Expect = e-147
Identities = 275/393 (69%), Positives = 315/393 (80%), Gaps = 9/393 (2%)
Query: 17 RLSPEELVRQTRQVVQGLEALRAEHHGLAGHLA---EALAGQGPAAGLEMLEEKQQVVSH 73
RLS EE++ TR V QGLEALR+EH + L+ E L G GL + EK + +
Sbjct: 34 RLSQEEILGSTRLVSQGLEALRSEHQAVLQSLSQTIECLQQGGHEEGL--VHEKARQLRR 91
Query: 74 SLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRAS 133
S+E IELGL EAQV+LAL++H+ +E+EKQ+LR+Q RRL QEN WLR+EL TQ+RL+ S
Sbjct: 92 SMENIELGLSEAQVMLALASHLSTVESEKQKLRAQVRRLCQENQWLRDELAGTQQRLQRS 151
Query: 134 EESVAQLEEEKRHLEFLGQLRQYDPPAE-SQQSESPPRRDSLASLFPSEEEERKG---PE 189
E++VAQLEEEK+HLEFLGQLRQYD S++ E +DSL LFP+EEEE
Sbjct: 152 EQAVAQLEEEKKHLEFLGQLRQYDEDGHTSEEKEGDATKDSLDDLFPNEEEEDPSNGLSR 211
Query: 190 AAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVA 249
GA AAQQGGYEIPARLRTLHNLVIQYA QGRYEVAVPLC+QALEDLER+SG HPDVA
Sbjct: 212 GQGATAAQQGGYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVA 271
Query: 250 TMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYRE 309
TMLNILALVYRDQNKYKEA LL+DAL IRE TLGP+HPAVAATLNNLAVLYGKRG+Y+E
Sbjct: 272 TMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKE 331
Query: 310 AEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGP 369
AEPLCQRALEIREKVLG +HPDVAKQLNNLALLCQNQGK+E VER+Y RAL+IYE GP
Sbjct: 332 AEPLCQRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQLGP 391
Query: 370 HDPNVAKTKNNLASAYLKQNKYQQAEELYKEIL 402
+PNVA+TKNNLAS YLKQ KY +AE LYKEIL
Sbjct: 392 DNPNVARTKNNLASCYLKQGKYAEAETLYKEIL 424
Score = 79.3 bits (194), Expect = 7e-15
Identities = 105/389 (26%), Positives = 137/389 (35%), Gaps = 146/389 (37%)
Query: 200 GYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATML------- 252
G + PA TL+NL + Y +G+Y+ A PLC++ALE E+ G HPDVA L
Sbjct: 306 GPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALEIREKVLGTNHPDVAKQLNNLALLC 365
Query: 253 -----------------------------------NILALVYRDQNKYKEATDLLHDAL- 276
N LA Y Q KY EA L + L
Sbjct: 366 QNQGKYEAVERYYQRALAIYEGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEILT 425
Query: 277 ---------------------QIREQTLGPEH---------------------PAVAATL 294
+ RE+ H P V TL
Sbjct: 426 RAHVQEFGSVDDDHKPIWMHAEEREEMSKSRHHEGGTPYAEYGGWYKACKVSSPTVNTTL 485
Query: 295 NNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVER 354
NL LY ++G+ AE L + AL R + D Q LL ++ G+ E
Sbjct: 486 RNLGALYRRQGKLEAAETLEECALRSRRQ-----GTDPISQTKVAELLGESDGRRTSQE- 539
Query: 355 HYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGAP 414
GP D K++ E+ +
Sbjct: 540 -------------GPGD----------------SVKFEGGED---------------ASV 555
Query: 415 NTGTAGDAEQALRRSSSLSKIRESIRRGSEKLVSRLRG-EAAAGAAGMKRAMSLNTLNVD 473
+GD L+RS SL KIR+ +RR SE LV +L+G E ++ MKRA SLN LN
Sbjct: 556 AVEWSGDGSGTLQRSGSLGKIRDVLRRSSELLVRKLQGTEPRPSSSNMKRAASLNYLN-- 613
Query: 474 APRAPGTQFPSWHLDKAPRTLSASTQDLS 502
P A Q R LSAST DLS
Sbjct: 614 QPSAAPLQ--------VSRGLSASTMDLS 634
>gi|41871955 kinesin-like 8 isoform a [Homo sapiens]
Length = 619
Score = 520 bits (1338), Expect = e-147
Identities = 275/393 (69%), Positives = 315/393 (80%), Gaps = 9/393 (2%)
Query: 17 RLSPEELVRQTRQVVQGLEALRAEHHGLAGHLA---EALAGQGPAAGLEMLEEKQQVVSH 73
RLS EE++ TR V QGLEALR+EH + L+ E L G GL + EK + +
Sbjct: 16 RLSQEEILGSTRLVSQGLEALRSEHQAVLQSLSQTIECLQQGGHEEGL--VHEKARQLRR 73
Query: 74 SLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRAS 133
S+E IELGL EAQV+LAL++H+ +E+EKQ+LR+Q RRL QEN WLR+EL TQ+RL+ S
Sbjct: 74 SMENIELGLSEAQVMLALASHLSTVESEKQKLRAQVRRLCQENQWLRDELAGTQQRLQRS 133
Query: 134 EESVAQLEEEKRHLEFLGQLRQYDPPAE-SQQSESPPRRDSLASLFPSEEEERKG---PE 189
E++VAQLEEEK+HLEFLGQLRQYD S++ E +DSL LFP+EEEE
Sbjct: 134 EQAVAQLEEEKKHLEFLGQLRQYDEDGHTSEEKEGDATKDSLDDLFPNEEEEDPSNGLSR 193
Query: 190 AAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVA 249
GA AAQQGGYEIPARLRTLHNLVIQYA QGRYEVAVPLC+QALEDLER+SG HPDVA
Sbjct: 194 GQGATAAQQGGYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVA 253
Query: 250 TMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYRE 309
TMLNILALVYRDQNKYKEA LL+DAL IRE TLGP+HPAVAATLNNLAVLYGKRG+Y+E
Sbjct: 254 TMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKE 313
Query: 310 AEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGP 369
AEPLCQRALEIREKVLG +HPDVAKQLNNLALLCQNQGK+E VER+Y RAL+IYE GP
Sbjct: 314 AEPLCQRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQLGP 373
Query: 370 HDPNVAKTKNNLASAYLKQNKYQQAEELYKEIL 402
+PNVA+TKNNLAS YLKQ KY +AE LYKEIL
Sbjct: 374 DNPNVARTKNNLASCYLKQGKYAEAETLYKEIL 406
Score = 79.3 bits (194), Expect = 7e-15
Identities = 105/389 (26%), Positives = 137/389 (35%), Gaps = 146/389 (37%)
Query: 200 GYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATML------- 252
G + PA TL+NL + Y +G+Y+ A PLC++ALE E+ G HPDVA L
Sbjct: 288 GPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALEIREKVLGTNHPDVAKQLNNLALLC 347
Query: 253 -----------------------------------NILALVYRDQNKYKEATDLLHDAL- 276
N LA Y Q KY EA L + L
Sbjct: 348 QNQGKYEAVERYYQRALAIYEGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEILT 407
Query: 277 ---------------------QIREQTLGPEH---------------------PAVAATL 294
+ RE+ H P V TL
Sbjct: 408 RAHVQEFGSVDDDHKPIWMHAEEREEMSKSRHHEGGTPYAEYGGWYKACKVSSPTVNTTL 467
Query: 295 NNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVER 354
NL LY ++G+ AE L + AL R + D Q LL ++ G+ E
Sbjct: 468 RNLGALYRRQGKLEAAETLEECALRSRRQ-----GTDPISQTKVAELLGESDGRRTSQE- 521
Query: 355 HYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGAP 414
GP D K++ E+ +
Sbjct: 522 -------------GPGD----------------SVKFEGGED---------------ASV 537
Query: 415 NTGTAGDAEQALRRSSSLSKIRESIRRGSEKLVSRLRG-EAAAGAAGMKRAMSLNTLNVD 473
+GD L+RS SL KIR+ +RR SE LV +L+G E ++ MKRA SLN LN
Sbjct: 538 AVEWSGDGSGTLQRSGSLGKIRDVLRRSSELLVRKLQGTEPRPSSSNMKRAASLNYLN-- 595
Query: 474 APRAPGTQFPSWHLDKAPRTLSASTQDLS 502
P A Q R LSAST DLS
Sbjct: 596 QPSAAPLQ--------VSRGLSASTMDLS 616
>gi|41871946 kinesin-like 8 isoform a [Homo sapiens]
Length = 619
Score = 520 bits (1338), Expect = e-147
Identities = 275/393 (69%), Positives = 315/393 (80%), Gaps = 9/393 (2%)
Query: 17 RLSPEELVRQTRQVVQGLEALRAEHHGLAGHLA---EALAGQGPAAGLEMLEEKQQVVSH 73
RLS EE++ TR V QGLEALR+EH + L+ E L G GL + EK + +
Sbjct: 16 RLSQEEILGSTRLVSQGLEALRSEHQAVLQSLSQTIECLQQGGHEEGL--VHEKARQLRR 73
Query: 74 SLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRAS 133
S+E IELGL EAQV+LAL++H+ +E+EKQ+LR+Q RRL QEN WLR+EL TQ+RL+ S
Sbjct: 74 SMENIELGLSEAQVMLALASHLSTVESEKQKLRAQVRRLCQENQWLRDELAGTQQRLQRS 133
Query: 134 EESVAQLEEEKRHLEFLGQLRQYDPPAE-SQQSESPPRRDSLASLFPSEEEERKG---PE 189
E++VAQLEEEK+HLEFLGQLRQYD S++ E +DSL LFP+EEEE
Sbjct: 134 EQAVAQLEEEKKHLEFLGQLRQYDEDGHTSEEKEGDATKDSLDDLFPNEEEEDPSNGLSR 193
Query: 190 AAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVA 249
GA AAQQGGYEIPARLRTLHNLVIQYA QGRYEVAVPLC+QALEDLER+SG HPDVA
Sbjct: 194 GQGATAAQQGGYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVA 253
Query: 250 TMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYRE 309
TMLNILALVYRDQNKYKEA LL+DAL IRE TLGP+HPAVAATLNNLAVLYGKRG+Y+E
Sbjct: 254 TMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKE 313
Query: 310 AEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGP 369
AEPLCQRALEIREKVLG +HPDVAKQLNNLALLCQNQGK+E VER+Y RAL+IYE GP
Sbjct: 314 AEPLCQRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQLGP 373
Query: 370 HDPNVAKTKNNLASAYLKQNKYQQAEELYKEIL 402
+PNVA+TKNNLAS YLKQ KY +AE LYKEIL
Sbjct: 374 DNPNVARTKNNLASCYLKQGKYAEAETLYKEIL 406
Score = 79.3 bits (194), Expect = 7e-15
Identities = 105/389 (26%), Positives = 137/389 (35%), Gaps = 146/389 (37%)
Query: 200 GYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATML------- 252
G + PA TL+NL + Y +G+Y+ A PLC++ALE E+ G HPDVA L
Sbjct: 288 GPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALEIREKVLGTNHPDVAKQLNNLALLC 347
Query: 253 -----------------------------------NILALVYRDQNKYKEATDLLHDAL- 276
N LA Y Q KY EA L + L
Sbjct: 348 QNQGKYEAVERYYQRALAIYEGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEILT 407
Query: 277 ---------------------QIREQTLGPEH---------------------PAVAATL 294
+ RE+ H P V TL
Sbjct: 408 RAHVQEFGSVDDDHKPIWMHAEEREEMSKSRHHEGGTPYAEYGGWYKACKVSSPTVNTTL 467
Query: 295 NNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVER 354
NL LY ++G+ AE L + AL R + D Q LL ++ G+ E
Sbjct: 468 RNLGALYRRQGKLEAAETLEECALRSRRQ-----GTDPISQTKVAELLGESDGRRTSQE- 521
Query: 355 HYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGAP 414
GP D K++ E+ +
Sbjct: 522 -------------GPGD----------------SVKFEGGED---------------ASV 537
Query: 415 NTGTAGDAEQALRRSSSLSKIRESIRRGSEKLVSRLRG-EAAAGAAGMKRAMSLNTLNVD 473
+GD L+RS SL KIR+ +RR SE LV +L+G E ++ MKRA SLN LN
Sbjct: 538 AVEWSGDGSGTLQRSGSLGKIRDVLRRSSELLVRKLQGTEPRPSSSNMKRAASLNYLN-- 595
Query: 474 APRAPGTQFPSWHLDKAPRTLSASTQDLS 502
P A Q R LSAST DLS
Sbjct: 596 QPSAAPLQ--------VSRGLSASTMDLS 616
>gi|194306559 kinesin light chain 1 isoform 3 [Homo sapiens]
Length = 618
Score = 513 bits (1321), Expect = e-145
Identities = 259/392 (66%), Positives = 321/392 (81%), Gaps = 5/392 (1%)
Query: 16 ERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSL 75
E+L+ +E++ +T+QV+QGLEAL+ EH+ + L E L ++EEK ++ SL
Sbjct: 17 EKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSL 76
Query: 76 EAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEE 135
E +ELGL EAQV++ALS H+ A+E+EKQ+LR+Q RRL QEN WLR+EL TQ++L+ SE+
Sbjct: 77 EMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQ 136
Query: 136 SVAQLEEEKRHLEFLGQLRQYDPP-AESQQSESPPRRDSLASLFPSEEEER----KGPEA 190
SVAQLEEEK+HLEF+ QL++YD + S+ ++ ++ L LFP++E++ + +
Sbjct: 137 SVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDEDDPGQGIQQQHS 196
Query: 191 AGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVAT 250
+ AAAAQQGGYEIPARLRTLHNLVIQYA QGRYEVAVPLC+QALEDLE++SGH HPDVAT
Sbjct: 197 SAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVAT 256
Query: 251 MLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREA 310
MLNILALVYRDQNKYK+A +LL+DAL IRE+TLG +HPAVAATLNNLAVLYGKRG+Y+EA
Sbjct: 257 MLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEA 316
Query: 311 EPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPH 370
EPLC+RALEIREKVLG DHPDVAKQLNNLALLCQNQGK+E+VE +Y RAL IY+ GP
Sbjct: 317 EPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPD 376
Query: 371 DPNVAKTKNNLASAYLKQNKYQQAEELYKEIL 402
DPNVAKTKNNLAS YLKQ K++QAE LYKEIL
Sbjct: 377 DPNVAKTKNNLASCYLKQGKFKQAETLYKEIL 408
Score = 75.9 bits (185), Expect = 8e-14
Identities = 84/337 (24%), Positives = 123/337 (36%), Gaps = 128/337 (37%)
Query: 200 GYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATML------- 252
G + PA TL+NL + Y +G+Y+ A PLC++ALE E+ G HPDVA L
Sbjct: 290 GKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLC 349
Query: 253 -----------------------------------NILALVYRDQNKYKEATDLLHDAL- 276
N LA Y Q K+K+A L + L
Sbjct: 350 QNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILT 409
Query: 277 ---------------------QIREQTLGPEH-------------------PAVAATLNN 296
+ RE+ G + P V TL N
Sbjct: 410 RAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKN 469
Query: 297 LAVLYGKRGRYREAEPLCQRALEIREKVLGADHPD-VAKQLNNLALLCQNQGKFEDVERH 355
L LY ++G++ AE L + A+ R++ L H VA+ LN
Sbjct: 470 LGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLN------------------ 511
Query: 356 YARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGAPN 415
DP + + + S + KY+ + +E+ + +
Sbjct: 512 ---------------DPENMEKRRSRESLNVDVVKYESGPDGGEEV-----------SMS 545
Query: 416 TGTAGDAEQALRRSSSLSKIRESIRRGSEKLVSRLRG 452
GD +L+RS S SK+R SIRR SEKLV +L+G
Sbjct: 546 VEWNGDGTGSLKRSGSFSKLRASIRRSSEKLVRKLKG 582
>gi|110735431 kinesin light chain 1 isoform 2 [Homo sapiens]
Length = 573
Score = 513 bits (1321), Expect = e-145
Identities = 259/392 (66%), Positives = 321/392 (81%), Gaps = 5/392 (1%)
Query: 16 ERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSL 75
E+L+ +E++ +T+QV+QGLEAL+ EH+ + L E L ++EEK ++ SL
Sbjct: 17 EKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSL 76
Query: 76 EAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEE 135
E +ELGL EAQV++ALS H+ A+E+EKQ+LR+Q RRL QEN WLR+EL TQ++L+ SE+
Sbjct: 77 EMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQ 136
Query: 136 SVAQLEEEKRHLEFLGQLRQYDPP-AESQQSESPPRRDSLASLFPSEEEER----KGPEA 190
SVAQLEEEK+HLEF+ QL++YD + S+ ++ ++ L LFP++E++ + +
Sbjct: 137 SVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDEDDPGQGIQQQHS 196
Query: 191 AGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVAT 250
+ AAAAQQGGYEIPARLRTLHNLVIQYA QGRYEVAVPLC+QALEDLE++SGH HPDVAT
Sbjct: 197 SAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVAT 256
Query: 251 MLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREA 310
MLNILALVYRDQNKYK+A +LL+DAL IRE+TLG +HPAVAATLNNLAVLYGKRG+Y+EA
Sbjct: 257 MLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEA 316
Query: 311 EPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPH 370
EPLC+RALEIREKVLG DHPDVAKQLNNLALLCQNQGK+E+VE +Y RAL IY+ GP
Sbjct: 317 EPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPD 376
Query: 371 DPNVAKTKNNLASAYLKQNKYQQAEELYKEIL 402
DPNVAKTKNNLAS YLKQ K++QAE LYKEIL
Sbjct: 377 DPNVAKTKNNLASCYLKQGKFKQAETLYKEIL 408
Score = 109 bits (272), Expect = 7e-24
Identities = 83/251 (33%), Positives = 116/251 (46%), Gaps = 46/251 (18%)
Query: 200 GYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVY 259
G + PA TL+NL + Y +G+Y+ A PLC++ALE E+ G HPDVA LN LAL+
Sbjct: 290 GKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLC 349
Query: 260 RDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRAL- 318
++Q KY+E AL+I + LGP+ P VA T NNLA Y K+G++++AE L + L
Sbjct: 350 QNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILT 409
Query: 319 ---------------------EIREKVLG-------------------ADHPDVAKQLNN 338
E RE+ G D P V L N
Sbjct: 410 RAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKN 469
Query: 339 LALLCQNQGKFEDVERHYARAL-SIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEEL 397
L L + QGKFE E A+ S + L H VA+ N+ + K + E L
Sbjct: 470 LGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPEN----MEKRRSRESL 525
Query: 398 YKEILHKEDLP 408
+++ E P
Sbjct: 526 NVDVVKYESGP 536
>gi|33620730 kinesin light chain 1 isoform 1 [Homo sapiens]
Length = 560
Score = 513 bits (1321), Expect = e-145
Identities = 259/392 (66%), Positives = 321/392 (81%), Gaps = 5/392 (1%)
Query: 16 ERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSL 75
E+L+ +E++ +T+QV+QGLEAL+ EH+ + L E L ++EEK ++ SL
Sbjct: 17 EKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSL 76
Query: 76 EAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEE 135
E +ELGL EAQV++ALS H+ A+E+EKQ+LR+Q RRL QEN WLR+EL TQ++L+ SE+
Sbjct: 77 EMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQ 136
Query: 136 SVAQLEEEKRHLEFLGQLRQYDPP-AESQQSESPPRRDSLASLFPSEEEER----KGPEA 190
SVAQLEEEK+HLEF+ QL++YD + S+ ++ ++ L LFP++E++ + +
Sbjct: 137 SVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDEDDPGQGIQQQHS 196
Query: 191 AGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVAT 250
+ AAAAQQGGYEIPARLRTLHNLVIQYA QGRYEVAVPLC+QALEDLE++SGH HPDVAT
Sbjct: 197 SAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVAT 256
Query: 251 MLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREA 310
MLNILALVYRDQNKYK+A +LL+DAL IRE+TLG +HPAVAATLNNLAVLYGKRG+Y+EA
Sbjct: 257 MLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEA 316
Query: 311 EPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPH 370
EPLC+RALEIREKVLG DHPDVAKQLNNLALLCQNQGK+E+VE +Y RAL IY+ GP
Sbjct: 317 EPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPD 376
Query: 371 DPNVAKTKNNLASAYLKQNKYQQAEELYKEIL 402
DPNVAKTKNNLAS YLKQ K++QAE LYKEIL
Sbjct: 377 DPNVAKTKNNLASCYLKQGKFKQAETLYKEIL 408
Score = 109 bits (272), Expect = 7e-24
Identities = 83/251 (33%), Positives = 116/251 (46%), Gaps = 46/251 (18%)
Query: 200 GYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVY 259
G + PA TL+NL + Y +G+Y+ A PLC++ALE E+ G HPDVA LN LAL+
Sbjct: 290 GKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLC 349
Query: 260 RDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRAL- 318
++Q KY+E AL+I + LGP+ P VA T NNLA Y K+G++++AE L + L
Sbjct: 350 QNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILT 409
Query: 319 ---------------------EIREKVLG-------------------ADHPDVAKQLNN 338
E RE+ G D P V L N
Sbjct: 410 RAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKN 469
Query: 339 LALLCQNQGKFEDVERHYARAL-SIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEEL 397
L L + QGKFE E A+ S + L H VA+ N+ + K + E L
Sbjct: 470 LGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPEN----MEKRRSRESL 525
Query: 398 YKEILHKEDLP 408
+++ E P
Sbjct: 526 NVDVVKYESGP 536
>gi|198041734 kinesin light chain 2 isoform 1 [Homo sapiens]
Length = 622
Score = 506 bits (1302), Expect = e-143
Identities = 270/428 (63%), Positives = 319/428 (74%), Gaps = 6/428 (1%)
Query: 16 ERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSL 75
E+LS +E+V T+ V+QGLE LR EH L L AG+ +E+ ++ SL
Sbjct: 10 EKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLVAPEAGEAEPGS----QERCILLRRSL 65
Query: 76 EAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEE 135
EAIELGLGEAQV+LALS+H+GA+E+EKQ+LR+Q RRL QEN WLREEL TQ++L+ SE+
Sbjct: 66 EAIELGLGEAQVILALSSHLGAVESEKQKLRAQVRRLVQENQWLREELAGTQQKLQRSEQ 125
Query: 136 SVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEERKGPEAAGA-A 194
+VAQLEEEK+HL F+ Q+R+ D A + + +D+L LFP+E+E+ P G
Sbjct: 126 AVAQLEEEKQHLLFMSQIRKLDEDASPNEEKGDVPKDTLDDLFPNEDEQSPAPSPGGGDV 185
Query: 195 AAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNI 254
+ Q GGYEIPARLRTLHNLVIQYA QGRYEVAVPLC+QALEDLE++SGH HPDVATMLNI
Sbjct: 186 SGQHGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNI 245
Query: 255 LALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLC 314
LALVYRDQNKYKEA LL+DAL IRE+TLG +HPAVAATLNNLAVLYGKRG+Y+EAEPLC
Sbjct: 246 LALVYRDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLC 305
Query: 315 QRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDPNV 374
+RALEIREKVLG HPDVAKQL+NLALLCQNQGK E+VE +Y RAL IY GP DPNV
Sbjct: 306 KRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNV 365
Query: 375 AKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGAPNTGTAGDAEQALRRSSSLSK 434
AKTKNNLAS YLKQ KYQ AE LYKEIL + G+ N A R S K
Sbjct: 366 AKTKNNLASCYLKQGKYQDAETLYKEILTRAH-EKEFGSVNGDNKPIWMHAEEREESKDK 424
Query: 435 IRESIRRG 442
R+S G
Sbjct: 425 RRDSAPYG 432
>gi|198041731 kinesin light chain 2 isoform 1 [Homo sapiens]
Length = 622
Score = 506 bits (1302), Expect = e-143
Identities = 270/428 (63%), Positives = 319/428 (74%), Gaps = 6/428 (1%)
Query: 16 ERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSL 75
E+LS +E+V T+ V+QGLE LR EH L L AG+ +E+ ++ SL
Sbjct: 10 EKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLVAPEAGEAEPGS----QERCILLRRSL 65
Query: 76 EAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEE 135
EAIELGLGEAQV+LALS+H+GA+E+EKQ+LR+Q RRL QEN WLREEL TQ++L+ SE+
Sbjct: 66 EAIELGLGEAQVILALSSHLGAVESEKQKLRAQVRRLVQENQWLREELAGTQQKLQRSEQ 125
Query: 136 SVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEERKGPEAAGA-A 194
+VAQLEEEK+HL F+ Q+R+ D A + + +D+L LFP+E+E+ P G
Sbjct: 126 AVAQLEEEKQHLLFMSQIRKLDEDASPNEEKGDVPKDTLDDLFPNEDEQSPAPSPGGGDV 185
Query: 195 AAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNI 254
+ Q GGYEIPARLRTLHNLVIQYA QGRYEVAVPLC+QALEDLE++SGH HPDVATMLNI
Sbjct: 186 SGQHGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNI 245
Query: 255 LALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLC 314
LALVYRDQNKYKEA LL+DAL IRE+TLG +HPAVAATLNNLAVLYGKRG+Y+EAEPLC
Sbjct: 246 LALVYRDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLC 305
Query: 315 QRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDPNV 374
+RALEIREKVLG HPDVAKQL+NLALLCQNQGK E+VE +Y RAL IY GP DPNV
Sbjct: 306 KRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNV 365
Query: 375 AKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGAPNTGTAGDAEQALRRSSSLSK 434
AKTKNNLAS YLKQ KYQ AE LYKEIL + G+ N A R S K
Sbjct: 366 AKTKNNLASCYLKQGKYQDAETLYKEILTRAH-EKEFGSVNGDNKPIWMHAEEREESKDK 424
Query: 435 IRESIRRG 442
R+S G
Sbjct: 425 RRDSAPYG 432
>gi|12383062 kinesin light chain 2 isoform 1 [Homo sapiens]
Length = 622
Score = 506 bits (1302), Expect = e-143
Identities = 270/428 (63%), Positives = 319/428 (74%), Gaps = 6/428 (1%)
Query: 16 ERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSL 75
E+LS +E+V T+ V+QGLE LR EH L L AG+ +E+ ++ SL
Sbjct: 10 EKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLVAPEAGEAEPGS----QERCILLRRSL 65
Query: 76 EAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEE 135
EAIELGLGEAQV+LALS+H+GA+E+EKQ+LR+Q RRL QEN WLREEL TQ++L+ SE+
Sbjct: 66 EAIELGLGEAQVILALSSHLGAVESEKQKLRAQVRRLVQENQWLREELAGTQQKLQRSEQ 125
Query: 136 SVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEERKGPEAAGA-A 194
+VAQLEEEK+HL F+ Q+R+ D A + + +D+L LFP+E+E+ P G
Sbjct: 126 AVAQLEEEKQHLLFMSQIRKLDEDASPNEEKGDVPKDTLDDLFPNEDEQSPAPSPGGGDV 185
Query: 195 AAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNI 254
+ Q GGYEIPARLRTLHNLVIQYA QGRYEVAVPLC+QALEDLE++SGH HPDVATMLNI
Sbjct: 186 SGQHGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNI 245
Query: 255 LALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLC 314
LALVYRDQNKYKEA LL+DAL IRE+TLG +HPAVAATLNNLAVLYGKRG+Y+EAEPLC
Sbjct: 246 LALVYRDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLC 305
Query: 315 QRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDPNV 374
+RALEIREKVLG HPDVAKQL+NLALLCQNQGK E+VE +Y RAL IY GP DPNV
Sbjct: 306 KRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNV 365
Query: 375 AKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGAPNTGTAGDAEQALRRSSSLSK 434
AKTKNNLAS YLKQ KYQ AE LYKEIL + G+ N A R S K
Sbjct: 366 AKTKNNLASCYLKQGKYQDAETLYKEILTRAH-EKEFGSVNGDNKPIWMHAEEREESKDK 424
Query: 435 IRESIRRG 442
R+S G
Sbjct: 425 RRDSAPYG 432
>gi|198041728 kinesin light chain 2 isoform 2 [Homo sapiens]
Length = 545
Score = 363 bits (933), Expect = e-100
Identities = 192/283 (67%), Positives = 216/283 (76%), Gaps = 2/283 (0%)
Query: 161 ESQQSESPPRRDSLASLFPSEEEERKGPEAAGA-AAAQQGGYEIPARLRTLHNLVIQYAG 219
E+Q+ + +D+L LFP+E+E+ P G + Q GGYEIPARLRTLHNLVIQYA
Sbjct: 74 EAQEEKGDVPKDTLDDLFPNEDEQSPAPSPGGGDVSGQHGGYEIPARLRTLHNLVIQYAS 133
Query: 220 QGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIR 279
QGRYEVAVPLC+QALEDLE++SGH HPDVATMLNILALVYRDQNKYKEA LL+DAL IR
Sbjct: 134 QGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIR 193
Query: 280 EQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNL 339
E+TLG +HPAVAATLNNLAVLYGKRG+Y+EAEPLC+RALEIREKVLG HPDVAKQL+NL
Sbjct: 194 EKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNL 253
Query: 340 ALLCQNQGKFEDVERHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYK 399
ALLCQNQGK E+VE +Y RAL IY GP DPNVAKTKNNLAS YLKQ KYQ AE LYK
Sbjct: 254 ALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYK 313
Query: 400 EILHKEDLPAPLGAPNTGTAGDAEQALRRSSSLSKIRESIRRG 442
EIL + G+ N A R S K R+S G
Sbjct: 314 EILTRAH-EKEFGSVNGDNKPIWMHAEEREESKDKRRDSAPYG 355
Score = 165 bits (417), Expect = 1e-40
Identities = 168/546 (30%), Positives = 239/546 (43%), Gaps = 76/546 (13%)
Query: 16 ERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSL 75
E+LS +E+V T+ V+QGLE LR EH L L AG+ +E+ ++ SL
Sbjct: 10 EKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLVAPEAGEAEPGS----QERCILLRRSL 65
Query: 76 EAIELGLGEAQVLLALSAHVGALEAE-------KQRLRSQARRLAQENVWLREELEETQR 128
EAIELGLGEAQ G + + + +S A +V + E
Sbjct: 66 EAIELGLGEAQ------EEKGDVPKDTLDDLFPNEDEQSPAPSPGGGDVSGQHGGYEIPA 119
Query: 129 RLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFP-SEEEERKG 187
RLR V Q + R+ + +Q E P ++ ++ ++ K
Sbjct: 120 RLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKY 179
Query: 188 PEAAG------AAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSS 241
EAA A + G + PA TL+NL + Y +G+Y+ A PLC++ALE E+
Sbjct: 180 KEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVL 239
Query: 242 GHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLY 301
G HPDVA L+ LAL+ ++Q K +E AL+I LGP+ P VA T NNLA Y
Sbjct: 240 GKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCY 299
Query: 302 GKRGRYREAEPLCQRAL-EIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARAL 360
K+G+Y++AE L + L EK G+ + D + +++ K D Y
Sbjct: 300 LKQGKYQDAETLYKEILTRAHEKEFGSVNGDNKPIWMHAEEREESKDKRRD-SAPYGEYG 358
Query: 361 SIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEEL-------------------YKEI 401
S Y+A P V T +L + Y +Q K + A L E+
Sbjct: 359 SWYKAC-KVDSPTVNTTLRSLGALYRRQGKLEAAHTLEDCASRNRKQGLDPASQTKVVEL 417
Query: 402 L-----------HKEDLPAPLG----------APNTGTAGDAEQALRRSSSLSKIRESIR 440
L D+ G P GD +LRRS S K+R+++R
Sbjct: 418 LKDGSGRRGDRRSSRDMAGGAGPRSESDLEDVGPTAEWNGDGSGSLRRSGSFGKLRDALR 477
Query: 441 RGSEKLVSRLRGEAAAGAAG--MKRAMSLNTLN--VDAPRAPGTQFPSWHLDKAPRTLSA 496
R SE LV +L+G MKRA SLN LN V+ P PG S RTLS+
Sbjct: 478 RSSEMLVKKLQGGTPQEPPNPRMKRASSLNFLNKSVEEPTQPGGTGLS-----DSRTLSS 532
Query: 497 STQDLS 502
S+ DLS
Sbjct: 533 SSMDLS 538
>gi|19923891 kinesin-like 8 isoform c [Homo sapiens]
Length = 315
Score = 337 bits (863), Expect = 2e-92
Identities = 183/282 (64%), Positives = 215/282 (76%), Gaps = 9/282 (3%)
Query: 17 RLSPEELVRQTRQVVQGLEALRAEHHGLAGHLA---EALAGQGPAAGLEMLEEKQQVVSH 73
RLS EE++ TR V QGLEALR+EH + L+ E L G GL + EK + +
Sbjct: 16 RLSQEEILGSTRLVSQGLEALRSEHQAVLQSLSQTIECLQQGGHEEGL--VHEKARQLRR 73
Query: 74 SLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRAS 133
S+E IELGL EAQV+LAL++H+ +E+EKQ+LR+Q RRL QEN WLR+EL TQ+RL+ S
Sbjct: 74 SMENIELGLSEAQVMLALASHLSTVESEKQKLRAQVRRLCQENQWLRDELAGTQQRLQRS 133
Query: 134 EESVAQLEEEKRHLEFLGQLRQYDPPAE-SQQSESPPRRDSLASLFPSEEEERKG---PE 189
E++VAQLEEEK+HLEFLGQLRQYD S++ E +DSL LFP+EEEE
Sbjct: 134 EQAVAQLEEEKKHLEFLGQLRQYDEDGHTSEEKEGDATKDSLDDLFPNEEEEDPSNGLSR 193
Query: 190 AAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVA 249
GA AAQQGGYEIPARLRTLHNLVIQYA QGRYEVAVPLC+QALEDLER+SG HPDVA
Sbjct: 194 GQGATAAQQGGYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVA 253
Query: 250 TMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVA 291
TMLNILALVYRDQNKYKEA LL+DAL IRE TLGP+HPAV+
Sbjct: 254 TMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVS 295
Score = 40.8 bits (94), Expect = 0.003
Identities = 26/77 (33%), Positives = 37/77 (48%)
Query: 326 GADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDPNVAKTKNNLASAY 385
G + P + L+NL + QG++E +AL E G P+VA N LA Y
Sbjct: 204 GYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVY 263
Query: 386 LKQNKYQQAEELYKEIL 402
QNKY++A L + L
Sbjct: 264 RDQNKYKEAAHLLNDAL 280
>gi|34304360 nephrocystin 3 [Homo sapiens]
Length = 1330
Score = 136 bits (342), Expect = 5e-32
Identities = 81/212 (38%), Positives = 115/212 (54%)
Query: 200 GYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVY 259
G + P RTL+ L + Y Q E A +++LE ER G HPD A LN LA +
Sbjct: 1086 GKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALC 1145
Query: 260 RDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALE 319
++ +Y +A +L AL IR + L P+HP++A T+ +LA+LY K G+ +A PL + A+E
Sbjct: 1146 NEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVE 1205
Query: 320 IREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDPNVAKTKN 379
IR+K G HP VA L NLA+L K + Y RAL IYE G P V +T
Sbjct: 1206 IRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLK 1265
Query: 380 NLASAYLKQNKYQQAEELYKEILHKEDLPAPL 411
NLA + +++A ELYK + ++ L
Sbjct: 1266 NLAVLSYEGGDFEKAAELYKRAMEIKEAETSL 1297
Score = 126 bits (316), Expect = 5e-29
Identities = 81/220 (36%), Positives = 109/220 (49%), Gaps = 24/220 (10%)
Query: 204 PARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQN 263
P ++LH L Y ++ A L +QALE E + G HP A L LA +Y+ QN
Sbjct: 982 PRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQN 1041
Query: 264 KYKEATD------------------------LLHDALQIREQTLGPEHPAVAATLNNLAV 299
KY++A L ALQ+ E TLG + P A TLN L V
Sbjct: 1042 KYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGV 1101
Query: 300 LYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARA 359
LY + A+ +R+LE+RE+VLG DHPD A+ LNNLA LC + +++ E Y RA
Sbjct: 1102 LYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERA 1161
Query: 360 LSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYK 399
L I P P++A T +LA Y K K +A LY+
Sbjct: 1162 LDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYE 1201
Score = 117 bits (294), Expect = 2e-26
Identities = 79/218 (36%), Positives = 115/218 (52%), Gaps = 6/218 (2%)
Query: 189 EAAGAAAAQQGGYEIPARLRT----LHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHC 244
EA +Q YE R +H I+ G Y A+ L R+AL+ E + G
Sbjct: 1031 EALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGN-LYGFAL-LRRRALQLEELTLGKD 1088
Query: 245 HPDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKR 304
PD A LN L ++Y QN + A L +L++RE+ LGP+HP A +LNNLA L ++
Sbjct: 1089 TPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEK 1148
Query: 305 GRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYE 364
+Y +AE L +RAL+IR + L DHP +A + +LA+L + GK + Y A+ I +
Sbjct: 1149 KQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQ 1208
Query: 365 ALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEIL 402
GP P+VA NLA Y + K+ +A LY+ L
Sbjct: 1209 KSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERAL 1246
Score = 86.7 bits (213), Expect = 5e-17
Identities = 64/221 (28%), Positives = 100/221 (45%), Gaps = 35/221 (15%)
Query: 216 QYAGQGRYEVAVPLCRQALEDLERSSGHCHPD-----VATMLNILALVYRDQNKYKEATD 270
Q+ G+ + +A + + L++ +C + +A + L +D +A
Sbjct: 909 QFVGKDKSAMAT----EYFDSLKQYEKNCEGEDNMSCLADLYETLGRFLKDLGLLSQAIV 964
Query: 271 LLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHP 330
L +L+IRE L P+HP VA +L+ LA +Y + ++ AE L ++ALEI E GADHP
Sbjct: 965 PLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHP 1024
Query: 331 DVAKQLNNLALLCQNQGKFEDVERHY-------------------------ARALSIYEA 365
A++L LA L Q Q K+E E H+ RAL + E
Sbjct: 1025 YTARELEALATLYQKQNKYEQAE-HFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEEL 1083
Query: 366 LGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKED 406
G P+ A+T N L Y QN + A++ K L +
Sbjct: 1084 TLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRE 1124
Score = 44.7 bits (104), Expect = 2e-04
Identities = 36/123 (29%), Positives = 56/123 (45%), Gaps = 5/123 (4%)
Query: 358 RALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGAPNTG 417
R+L I E P P VA++ + LAS Y++ K+ AE+LYK+ L + P T
Sbjct: 968 RSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTA 1027
Query: 418 TAGDAEQALRRSSSLSKIRESIRRGSEKL---VSRLRGEAAAGAAGMKRAMSLN--TLNV 472
+A L + + + E R+ S K+ + +G A +RA+ L TL
Sbjct: 1028 RELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGK 1087
Query: 473 DAP 475
D P
Sbjct: 1088 DTP 1090
>gi|87162455 hypothetical protein LOC23277 [Homo sapiens]
Length = 1309
Score = 60.1 bits (144), Expect = 5e-09
Identities = 46/181 (25%), Positives = 77/181 (42%)
Query: 220 QGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIR 279
QG + L +AL G H + L +LA ++ Y EA A+ +
Sbjct: 991 QGFLKEGCELINEALNLFNNVYGAMHVETCACLRLLARLHYIMGDYAEALSNQQKAVLMS 1050
Query: 280 EQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNL 339
E+ +G EHP +LA+ + A L RA + V G DHP++A NN+
Sbjct: 1051 ERVMGTEHPNTIQEYMHLALYCFASSQLSTALSLLYRARYLMLLVFGEDHPEMALLDNNI 1110
Query: 340 ALLCQNQGKFEDVERHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYK 399
L+ +++ R AL++ GP VA + + +A Y + +++ A + K
Sbjct: 1111 GLVLHGVMEYDLSLRFLENALAVSTKYHGPKALKVALSHHLVARVYESKAEFRSALQHEK 1170
Query: 400 E 400
E
Sbjct: 1171 E 1171
Score = 43.9 bits (102), Expect = 3e-04
Identities = 44/168 (26%), Positives = 73/168 (43%), Gaps = 7/168 (4%)
Query: 221 GRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIRE 280
G Y A+ ++A+ ER G HP+ LAL ++ A LL+ A +
Sbjct: 1034 GDYAEALSNQQKAVLMSERVMGTEHPNTIQEYMHLALYCFASSQLSTALSLLYRARYLML 1093
Query: 281 QTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLA 340
G +HP +A NN+ ++ Y + + AL + K G VA + +A
Sbjct: 1094 LVFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALAVSTKYHGPKALKVALSHHLVA 1153
Query: 341 LLCQNQGKFEDVERHYARALSIYEA-LGGPHDPNVAKTKNNLASAYLK 387
+ +++ +F +H +IY+ LG H+ KTK +S YLK
Sbjct: 1154 RVYESKAEFRSALQHEKEGYTIYKTQLGEDHE----KTKE--SSEYLK 1195
>gi|18104962 amyloid beta precursor protein-binding protein 2 [Homo
sapiens]
Length = 585
Score = 57.0 bits (136), Expect = 4e-08
Identities = 37/139 (26%), Positives = 71/139 (51%), Gaps = 1/139 (0%)
Query: 261 DQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEI 320
+Q +EA DL +LQ+ ++ G + A NL LY +++EAE + +A++I
Sbjct: 399 EQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQI 458
Query: 321 REKVLGADHPDVAKQLNNLALLCQ-NQGKFEDVERHYARALSIYEALGGPHDPNVAKTKN 379
+E++LG + +VA + +LA L + ++E+ E+ Y R+++I + L G +
Sbjct: 459 KEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYR 518
Query: 380 NLASAYLKQNKYQQAEELY 398
L Y Y++ E +
Sbjct: 519 GLIKLYNSIGNYEKVFEYH 537
Score = 55.8 bits (133), Expect = 9e-08
Identities = 36/125 (28%), Positives = 63/125 (50%), Gaps = 1/125 (0%)
Query: 233 ALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAA 292
+L+ +++ G + A L +Y+ K+KEA ++ A+QI+EQ LG E VA
Sbjct: 413 SLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVAL 472
Query: 293 TLNNLAVLYG-KRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFED 351
++ +LA LY +Y AE L R++ I +K+ G + + L L + G +E
Sbjct: 473 SVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSIGNYEK 532
Query: 352 VERHY 356
V ++
Sbjct: 533 VFEYH 537
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 56.2 bits (134), Expect = 7e-08
Identities = 52/187 (27%), Positives = 80/187 (42%), Gaps = 32/187 (17%)
Query: 212 NLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEATDL 271
NL Y QG ++A+ R+A+E P LA +++ EA D
Sbjct: 254 NLACVYYEQGLIDLAIDTYRRAIE--------LQPHFPDAYCNLANALKEKGSVAEAEDC 305
Query: 272 LHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPD 331
+ AL+ L P H A +LNNLA + ++G EA L ++ALE+ P+
Sbjct: 306 YNTALR-----LCPTH---ADSLNNLANIKREQGNIEEAVRLYRKALEV--------FPE 349
Query: 332 VAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKY 391
A +NLA + Q QGK ++ HY A+ I P A +N+ + +
Sbjct: 350 FAAAHSNLASVLQQQGKLQEALMHYKEAIRI--------SPTFADAYSNMGNTLKEMQDV 401
Query: 392 QQAEELY 398
Q A + Y
Sbjct: 402 QGALQCY 408
Score = 53.9 bits (128), Expect = 3e-07
Identities = 48/157 (30%), Positives = 68/157 (43%), Gaps = 24/157 (15%)
Query: 246 PDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRG 305
P+ A + LA VY +Q A D A++++ P P NLA ++G
Sbjct: 246 PNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQ-----PHFPDAYC---NLANALKEKG 297
Query: 306 RYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEA 365
EAE AL + P A LNNLA + + QG E+ R Y +AL ++
Sbjct: 298 SVAEAEDCYNTALRLC--------PTHADSLNNLANIKREQGNIEEAVRLYRKALEVF-- 347
Query: 366 LGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEIL 402
P A +NLAS +Q K Q+A YKE +
Sbjct: 348 ------PEFAAAHSNLASVLQQQGKLQEALMHYKEAI 378
Score = 35.8 bits (81), Expect = 0.094
Identities = 42/159 (26%), Positives = 65/159 (40%), Gaps = 24/159 (15%)
Query: 204 PARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQN 263
P +L+NL QG E AV L R+ALE P+ A + LA V + Q
Sbjct: 314 PTHADSLNNLANIKREQGNIEEAVRLYRKALE--------VFPEFAAAHSNLASVLQQQG 365
Query: 264 KYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREK 323
K +EA +A++I T + + TL + + G Y RA++I
Sbjct: 366 KLQEALMHYKEAIRI-SPTFADAYSNMGNTLKEMQDVQGALQCY-------TRAIQI--- 414
Query: 324 VLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSI 362
+P A +NLA + ++ G + Y AL +
Sbjct: 415 -----NPAFADAHSNLASIHKDSGNIPEAIASYRTALKL 448
Score = 32.3 bits (72), Expect = 1.0
Identities = 34/176 (19%), Positives = 71/176 (40%), Gaps = 30/176 (17%)
Query: 236 DLERSSGHC------HPDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPA 289
D E + HC PD +L +L+ ++ + + A++ ++P
Sbjct: 26 DFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIK--------QNPL 77
Query: 290 VAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKF 349
+A +NL +Y +RG+ +EA + AL ++ PD NLA G
Sbjct: 78 LAEAYSNLGNVYKERGQLQEAIEHYRHALRLK--------PDFIDGYINLAAALVAAGDM 129
Query: 350 EDVERHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKE 405
E + Y AL ++P++ +++L + + ++A+ Y + + +
Sbjct: 130 EGAVQAYVSALQ--------YNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQ 177
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 56.2 bits (134), Expect = 7e-08
Identities = 52/187 (27%), Positives = 80/187 (42%), Gaps = 32/187 (17%)
Query: 212 NLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEATDL 271
NL Y QG ++A+ R+A+E P LA +++ EA D
Sbjct: 264 NLACVYYEQGLIDLAIDTYRRAIE--------LQPHFPDAYCNLANALKEKGSVAEAEDC 315
Query: 272 LHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPD 331
+ AL+ L P H A +LNNLA + ++G EA L ++ALE+ P+
Sbjct: 316 YNTALR-----LCPTH---ADSLNNLANIKREQGNIEEAVRLYRKALEV--------FPE 359
Query: 332 VAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKY 391
A +NLA + Q QGK ++ HY A+ I P A +N+ + +
Sbjct: 360 FAAAHSNLASVLQQQGKLQEALMHYKEAIRI--------SPTFADAYSNMGNTLKEMQDV 411
Query: 392 QQAEELY 398
Q A + Y
Sbjct: 412 QGALQCY 418
Score = 53.9 bits (128), Expect = 3e-07
Identities = 48/157 (30%), Positives = 68/157 (43%), Gaps = 24/157 (15%)
Query: 246 PDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRG 305
P+ A + LA VY +Q A D A++++ P P NLA ++G
Sbjct: 256 PNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQ-----PHFPDAYC---NLANALKEKG 307
Query: 306 RYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEA 365
EAE AL + P A LNNLA + + QG E+ R Y +AL ++
Sbjct: 308 SVAEAEDCYNTALRLC--------PTHADSLNNLANIKREQGNIEEAVRLYRKALEVF-- 357
Query: 366 LGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEIL 402
P A +NLAS +Q K Q+A YKE +
Sbjct: 358 ------PEFAAAHSNLASVLQQQGKLQEALMHYKEAI 388
Score = 35.8 bits (81), Expect = 0.094
Identities = 42/159 (26%), Positives = 65/159 (40%), Gaps = 24/159 (15%)
Query: 204 PARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQN 263
P +L+NL QG E AV L R+ALE P+ A + LA V + Q
Sbjct: 324 PTHADSLNNLANIKREQGNIEEAVRLYRKALE--------VFPEFAAAHSNLASVLQQQG 375
Query: 264 KYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREK 323
K +EA +A++I T + + TL + + G Y RA++I
Sbjct: 376 KLQEALMHYKEAIRI-SPTFADAYSNMGNTLKEMQDVQGALQCY-------TRAIQI--- 424
Query: 324 VLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSI 362
+P A +NLA + ++ G + Y AL +
Sbjct: 425 -----NPAFADAHSNLASIHKDSGNIPEAIASYRTALKL 458
Score = 32.3 bits (72), Expect = 1.0
Identities = 34/176 (19%), Positives = 71/176 (40%), Gaps = 30/176 (17%)
Query: 236 DLERSSGHC------HPDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPA 289
D E + HC PD +L +L+ ++ + + A++ ++P
Sbjct: 36 DFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIK--------QNPL 87
Query: 290 VAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKF 349
+A +NL +Y +RG+ +EA + AL ++ PD NLA G
Sbjct: 88 LAEAYSNLGNVYKERGQLQEAIEHYRHALRLK--------PDFIDGYINLAAALVAAGDM 139
Query: 350 EDVERHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKE 405
E + Y AL ++P++ +++L + + ++A+ Y + + +
Sbjct: 140 EGAVQAYVSALQ--------YNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQ 187
>gi|22547159 tetratricopeptide repeat domain 19 [Homo sapiens]
Length = 501
Score = 54.3 bits (129), Expect = 3e-07
Identities = 36/148 (24%), Positives = 75/148 (50%), Gaps = 9/148 (6%)
Query: 262 QNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLA--VLYGKRGRYREAEPLCQRALE 319
+ K + +L D + + E+ H + L+ A +L+ K+ +A+ + ++AL+
Sbjct: 331 EEKIEREKELAEDIMSVEEKA--NTHLLLGMCLDACARYLLFSKQPS--QAQRMYEKALQ 386
Query: 320 IREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDPNVAKTKN 379
I E++ G HP +++LA QG+F++ + RA + + + P + +
Sbjct: 387 ISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI---NHPELHMVLS 443
Query: 380 NLASAYLKQNKYQQAEELYKEILHKEDL 407
NLA+ + + +Y QA+E+Y+E L + L
Sbjct: 444 NLAAVLMHRERYTQAKEIYQEALKQAKL 471
Score = 52.0 bits (123), Expect = 1e-06
Identities = 42/160 (26%), Positives = 70/160 (43%), Gaps = 19/160 (11%)
Query: 217 YAGQGRYEVAVP---LCRQALED-LERSS------------GHCHPDVATMLNILALVYR 260
YA Q R E AV C LE+ +ER + H + L+ A
Sbjct: 310 YAAQNRQEFAVAGYEFCISTLEEKIEREKELAEDIMSVEEKANTHLLLGMCLDACARYLL 369
Query: 261 DQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEI 320
+ +A + ALQI E+ G HP +++LA +GR+ EA QRA ++
Sbjct: 370 FSKQPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDL 429
Query: 321 REKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARAL 360
++ +HP++ L+NLA + ++ ++ + Y AL
Sbjct: 430 ARQI---NHPELHMVLSNLAAVLMHRERYTQAKEIYQEAL 466
>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
[Homo sapiens]
Length = 836
Score = 49.7 bits (117), Expect = 6e-06
Identities = 43/153 (28%), Positives = 65/153 (42%), Gaps = 19/153 (12%)
Query: 255 LALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLC 314
L V + Q+K EA +AL R +A L NL +L + R+ EA
Sbjct: 499 LGNVLKSQSKISEAESAYRNALYYRSN--------MADMLYNLGLLLQENSRFAEALHYY 550
Query: 315 QRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIY-EALGGPH--D 371
+ A+ R P +A N ++ NQG+ E+ R + + I E L PH
Sbjct: 551 KLAIGSR--------PTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHK 602
Query: 372 PNVAKTKNNLASAYLKQNKYQQAEELYKEILHK 404
+V NL Y +Q Y++A +YKE + K
Sbjct: 603 SSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQK 635
Score = 33.1 bits (74), Expect = 0.61
Identities = 28/111 (25%), Positives = 51/111 (45%), Gaps = 13/111 (11%)
Query: 210 LHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEAT 269
L+NL Y QG YE A+ + ++A++ + R ++ N++ Y +K EA
Sbjct: 609 LYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFA-----PQSLYNMMGEAYMRLSKLPEAE 663
Query: 270 DLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEI 320
++L+ + +H T L L G++ EAE L +A+E+
Sbjct: 664 HWYMESLRSK-----TDHIPAHLTYGKLLALTGRKS---EAEKLFLKAIEL 706
Score = 30.4 bits (67), Expect = 3.9
Identities = 56/263 (21%), Positives = 95/263 (36%), Gaps = 42/263 (15%)
Query: 212 NLVIQYAGQGRYEVAVPLCRQALE--DLERSSGHCHPD-VATMLNILALVYRDQNKYKEA 268
N I QGR E A + E D H H V + L L +Y +Q Y+EA
Sbjct: 566 NTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEA 625
Query: 269 TDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGAD 328
+ +A+Q + P+ + N + Y + + EAE +L + D
Sbjct: 626 LSVYKEAIQKMPRQFAPQ-----SLYNMMGEAYMRLSKLPEAEHWYMESLRSK-----TD 675
Query: 329 HPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQ 388
H L L G+ + E+ + +A+ + DP + L++
Sbjct: 676 HIPAHLTYGKLLAL---TGRKSEAEKLFLKAIEL--------DPTKGNCYMHYGQFLLEE 724
Query: 389 NKYQQAEELYKEILHKEDLPAPLGAPNTGTAGDAEQALRRSSSLSKIRESIRRGSEK--- 445
+ +A E+ K+ A L + +A LR++ S+ +EK
Sbjct: 725 ARLIEAAEMAKK-------AAELDSTEFDVVFNAAHMLRQA--------SLNEAAEKYYD 769
Query: 446 LVSRLRGEAAAGAAGMKRAMSLN 468
L +RLR A + + LN
Sbjct: 770 LAARLRPNYPAALMNLGAILHLN 792
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 48.5 bits (114), Expect = 1e-05
Identities = 108/474 (22%), Positives = 180/474 (37%), Gaps = 54/474 (11%)
Query: 17 RLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGP-----AAGLEMLEEKQQVV 71
+L P + +V G E++ E+ L H +E + L +EE++++
Sbjct: 1292 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA 1351
Query: 72 SHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLR 131
L E + ALE ++Q + A+ AQ +E + Q +
Sbjct: 1352 EQQRAEERERLAEVEA---------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 132 ASEESVAQLEEEKRHL-EFLGQLRQ---YDPPAESQQSESPPRRDSLASLFPSEEEERKG 187
EE+ +++KR + E L QLRQ + A+++Q+E+ R S EEE R
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER-----SRLRIEEEIRVV 1457
Query: 188 PEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGR--YEVAVPLCRQALEDLERSSGHCH 245
A Q+GG E L+ L + Q R E A L RQ ++ +R
Sbjct: 1458 RLQLEATERQRGGAE--GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR-QAE 1514
Query: 246 PDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRG 305
++A+ + A R++ + +A + L + E+ L A + V
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQ 1571
Query: 306 RYREAEPLCQRALEIR-----EKVLGADHPDVAKQLNNLALLCQNQGKF----EDVERHY 356
R EAE +RA E+ L +H VA+ Q Q + E+ ER
Sbjct: 1572 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL 1631
Query: 357 AR-ALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKE-------ILHKEDLP 408
R L EAL + +LA A ++ K + E + + +E
Sbjct: 1632 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1691
Query: 409 APLGAPNTGTAGDAEQALRRSSSLSKIRESIRRGS------EKLVSRLRGEAAA 456
L G A+Q L L ++R +G E+ ++RL+ EAAA
Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745
Score = 43.5 bits (101), Expect = 4e-04
Identities = 109/470 (23%), Positives = 170/470 (36%), Gaps = 54/470 (11%)
Query: 12 GLGPERLSPE-ELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQV 70
G +RL+ E EL+R + QG + + LA EA A +K+Q
Sbjct: 1703 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT----------QKRQE 1752
Query: 71 VSHSLEAIELGLGEAQVLLALSAHV-----GALEAEKQRLRSQA---RRLAQENVWLREE 122
+ L + E +VLLA A E KQRL ++A R LA+E LR
Sbjct: 1753 LEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1809
Query: 123 LEETQRRLRASEESVAQLEEEKRH-----LEFLGQLRQYDPPAESQQSESPPRRDSLASL 177
EE +R+ + +EE A+ E L +G+ + AE E + L L
Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869
Query: 178 FPSEEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDL 237
E +R+ E A Q +I RL L A E L +ED
Sbjct: 1870 AEDEAFQRRRLEEQAA----QHKADIEERLAQLRK-----ASDSELERQKGL----VEDT 1916
Query: 238 ERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIR---EQTLGPEHPAVAATL 294
R + ILAL + +L + +IR E TL + A
Sbjct: 1917 LRQRRQVEEE------ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970
Query: 295 NNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKF-EDVE 353
+ + R REAE Q++L E+ +++ L + + E E
Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEA-ARQRKAALEEVERLKAKVEEARRLRERAE 2029
Query: 354 RHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGA 413
+ AR L + A A+ K + + K+ + QQ + + +L + A
Sbjct: 2030 QESARQLQL--AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2087
Query: 414 PNTGTAGDAE-QALRRSSSLSKIRESIRRGSEKLVSRLRGEAAAGAAGMK 462
A +A QA R ++ + E R + + + A A AA K
Sbjct: 2088 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Score = 36.6 bits (83), Expect = 0.055
Identities = 64/254 (25%), Positives = 98/254 (38%), Gaps = 23/254 (9%)
Query: 16 ERL--SPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAG---QGPAAGLEMLEEKQ-- 68
ERL S EE + Q E LR E A A+A Q AA EM + K+
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174
Query: 69 QVVSHSLEAIELGLGEAQVLLALSAHV-GALEAEKQRLRSQARRLAQENVWLREELEETQ 127
+ +E L ++ L + H L+ E QRL+++A A++ + EEL +
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 128 RRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEERKG 187
++ + A++E E R L LR D Q E+ + +EE R
Sbjct: 2235 VQMEELSKLKARIEAENRAL----ILRDKDNTQRFLQEEAEKMKQ------VAEEAARLS 2284
Query: 188 PEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQG-----RYEVAVPLCRQALEDLERSSG 242
A AA +Q E A+ R L +++ Q R + L +Q E + +
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2344
Query: 243 HCHPDVATMLNILA 256
D M LA
Sbjct: 2345 RLQEDKEQMAQQLA 2358
Score = 34.7 bits (78), Expect = 0.21
Identities = 43/164 (26%), Positives = 69/164 (42%), Gaps = 11/164 (6%)
Query: 22 ELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSLEAIELG 81
EL R+ ++ Q + L+ + + E L + A L EK ++ +
Sbjct: 2454 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2513
Query: 82 LGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEESVAQLE 141
Q+ A L E+QR Q +++ QE L +EE +RR +EE V + +
Sbjct: 2514 AKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570
Query: 142 EEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEER 185
EE + LE Q RQ + E E+ R+ L L EE+ R
Sbjct: 2571 EELQQLE--QQRRQQE---ELLAEENQRLREQLQLL---EEQHR 2606
Score = 32.3 bits (72), Expect = 1.0
Identities = 38/140 (27%), Positives = 56/140 (40%), Gaps = 10/140 (7%)
Query: 66 EKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQ--RLRSQARRLAQENVWLREEL 123
E+Q V L EL E Q LA L AE++ RLR++ + Q+ L EEL
Sbjct: 1680 EEQAVRQRELAEQEL---EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736
Query: 124 EETQRRLRASEESVAQLEEEKRHLE-----FLGQLRQYDPPAESQQSESPPRRDSLASLF 178
QR A+ + +LE E + L + + + S +S R ++ A F
Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1796
Query: 179 PSEEEERKGPEAAGAAAAQQ 198
EE A A +Q
Sbjct: 1797 RELAEEAARLRALAEEAKRQ 1816
Score = 30.8 bits (68), Expect = 3.0
Identities = 41/144 (28%), Positives = 58/144 (40%), Gaps = 11/144 (7%)
Query: 3 VQVAAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAA--- 59
++V A E S E +Q + G AE LAE Q A
Sbjct: 1764 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1823
Query: 60 GLEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWL 119
E ++V++ L AI GEA L A + E E + R RRLA++ +
Sbjct: 1824 AARQRAEAERVLAEKLAAI----GEA-TRLKTEAEIALKEKEAENER--LRRLAEDEAFQ 1876
Query: 120 REELEETQRRLRAS-EESVAQLEE 142
R LEE + +A EE +AQL +
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRK 1900
Score = 30.0 bits (66), Expect = 5.1
Identities = 44/184 (23%), Positives = 81/184 (44%), Gaps = 28/184 (15%)
Query: 21 EELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQ----------- 69
EE RQ + ++ +E L+A+ A L E A Q A L++ +E Q
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEE-ARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHA 2055
Query: 70 -VVSHSLEAIELGLGEAQVLL------ALSAHVGALEAEKQRLRSQARRLAQENVWLREE 122
V + ++ L + Q +L A +A A EAE+ R++++ R AQ R +
Sbjct: 2056 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE-REAAQS----RRQ 2110
Query: 123 LEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEE 182
+EE +R +++EE + + E L + + + +Q ++ R+ A +E
Sbjct: 2111 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD---AEM 2167
Query: 183 EERK 186
E+ K
Sbjct: 2168 EKHK 2171
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 48.5 bits (114), Expect = 1e-05
Identities = 108/474 (22%), Positives = 180/474 (37%), Gaps = 54/474 (11%)
Query: 17 RLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGP-----AAGLEMLEEKQQVV 71
+L P + +V G E++ E+ L H +E + L +EE++++
Sbjct: 1296 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA 1355
Query: 72 SHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLR 131
L E + ALE ++Q + A+ AQ +E + Q +
Sbjct: 1356 EQQRAEERERLAEVEA---------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406
Query: 132 ASEESVAQLEEEKRHL-EFLGQLRQ---YDPPAESQQSESPPRRDSLASLFPSEEEERKG 187
EE+ +++KR + E L QLRQ + A+++Q+E+ R S EEE R
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER-----SRLRIEEEIRVV 1461
Query: 188 PEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGR--YEVAVPLCRQALEDLERSSGHCH 245
A Q+GG E L+ L + Q R E A L RQ ++ +R
Sbjct: 1462 RLQLEATERQRGGAE--GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR-QAE 1518
Query: 246 PDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRG 305
++A+ + A R++ + +A + L + E+ L A + V
Sbjct: 1519 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQ 1575
Query: 306 RYREAEPLCQRALEIR-----EKVLGADHPDVAKQLNNLALLCQNQGKF----EDVERHY 356
R EAE +RA E+ L +H VA+ Q Q + E+ ER
Sbjct: 1576 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL 1635
Query: 357 AR-ALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKE-------ILHKEDLP 408
R L EAL + +LA A ++ K + E + + +E
Sbjct: 1636 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1695
Query: 409 APLGAPNTGTAGDAEQALRRSSSLSKIRESIRRGS------EKLVSRLRGEAAA 456
L G A+Q L L ++R +G E+ ++RL+ EAAA
Sbjct: 1696 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1749
Score = 43.5 bits (101), Expect = 4e-04
Identities = 109/470 (23%), Positives = 170/470 (36%), Gaps = 54/470 (11%)
Query: 12 GLGPERLSPE-ELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQV 70
G +RL+ E EL+R + QG + + LA EA A +K+Q
Sbjct: 1707 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT----------QKRQE 1756
Query: 71 VSHSLEAIELGLGEAQVLLALSAHV-----GALEAEKQRLRSQA---RRLAQENVWLREE 122
+ L + E +VLLA A E KQRL ++A R LA+E LR
Sbjct: 1757 LEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1813
Query: 123 LEETQRRLRASEESVAQLEEEKRH-----LEFLGQLRQYDPPAESQQSESPPRRDSLASL 177
EE +R+ + +EE A+ E L +G+ + AE E + L L
Sbjct: 1814 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1873
Query: 178 FPSEEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDL 237
E +R+ E A Q +I RL L A E L +ED
Sbjct: 1874 AEDEAFQRRRLEEQAA----QHKADIEERLAQLRK-----ASDSELERQKGL----VEDT 1920
Query: 238 ERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIR---EQTLGPEHPAVAATL 294
R + ILAL + +L + +IR E TL + A
Sbjct: 1921 LRQRRQVEEE------ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1974
Query: 295 NNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKF-EDVE 353
+ + R REAE Q++L E+ +++ L + + E E
Sbjct: 1975 RQRQLAAEEERRRREAEERVQKSLAAEEEA-ARQRKAALEEVERLKAKVEEARRLRERAE 2033
Query: 354 RHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGA 413
+ AR L + A A+ K + + K+ + QQ + + +L + A
Sbjct: 2034 QESARQLQL--AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2091
Query: 414 PNTGTAGDAE-QALRRSSSLSKIRESIRRGSEKLVSRLRGEAAAGAAGMK 462
A +A QA R ++ + E R + + + A A AA K
Sbjct: 2092 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2141
Score = 36.6 bits (83), Expect = 0.055
Identities = 64/254 (25%), Positives = 98/254 (38%), Gaps = 23/254 (9%)
Query: 16 ERL--SPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAG---QGPAAGLEMLEEKQ-- 68
ERL S EE + Q E LR E A A+A Q AA EM + K+
Sbjct: 2119 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2178
Query: 69 QVVSHSLEAIELGLGEAQVLLALSAHV-GALEAEKQRLRSQARRLAQENVWLREELEETQ 127
+ +E L ++ L + H L+ E QRL+++A A++ + EEL +
Sbjct: 2179 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2238
Query: 128 RRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEERKG 187
++ + A++E E R L LR D Q E+ + +EE R
Sbjct: 2239 VQMEELSKLKARIEAENRAL----ILRDKDNTQRFLQEEAEKMKQ------VAEEAARLS 2288
Query: 188 PEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQG-----RYEVAVPLCRQALEDLERSSG 242
A AA +Q E A+ R L +++ Q R + L +Q E + +
Sbjct: 2289 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2348
Query: 243 HCHPDVATMLNILA 256
D M LA
Sbjct: 2349 RLQEDKEQMAQQLA 2362
Score = 34.7 bits (78), Expect = 0.21
Identities = 43/164 (26%), Positives = 69/164 (42%), Gaps = 11/164 (6%)
Query: 22 ELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSLEAIELG 81
EL R+ ++ Q + L+ + + E L + A L EK ++ +
Sbjct: 2458 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2517
Query: 82 LGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEESVAQLE 141
Q+ A L E+QR Q +++ QE L +EE +RR +EE V + +
Sbjct: 2518 AKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2574
Query: 142 EEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEER 185
EE + LE Q RQ + E E+ R+ L L EE+ R
Sbjct: 2575 EELQQLE--QQRRQQE---ELLAEENQRLREQLQLL---EEQHR 2610
Score = 32.3 bits (72), Expect = 1.0
Identities = 38/140 (27%), Positives = 56/140 (40%), Gaps = 10/140 (7%)
Query: 66 EKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQ--RLRSQARRLAQENVWLREEL 123
E+Q V L EL E Q LA L AE++ RLR++ + Q+ L EEL
Sbjct: 1684 EEQAVRQRELAEQEL---EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1740
Query: 124 EETQRRLRASEESVAQLEEEKRHLE-----FLGQLRQYDPPAESQQSESPPRRDSLASLF 178
QR A+ + +LE E + L + + + S +S R ++ A F
Sbjct: 1741 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1800
Query: 179 PSEEEERKGPEAAGAAAAQQ 198
EE A A +Q
Sbjct: 1801 RELAEEAARLRALAEEAKRQ 1820
Score = 30.8 bits (68), Expect = 3.0
Identities = 41/144 (28%), Positives = 58/144 (40%), Gaps = 11/144 (7%)
Query: 3 VQVAAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAA--- 59
++V A E S E +Q + G AE LAE Q A
Sbjct: 1768 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1827
Query: 60 GLEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWL 119
E ++V++ L AI GEA L A + E E + R RRLA++ +
Sbjct: 1828 AARQRAEAERVLAEKLAAI----GEA-TRLKTEAEIALKEKEAENER--LRRLAEDEAFQ 1880
Query: 120 REELEETQRRLRAS-EESVAQLEE 142
R LEE + +A EE +AQL +
Sbjct: 1881 RRRLEEQAAQHKADIEERLAQLRK 1904
Score = 30.0 bits (66), Expect = 5.1
Identities = 44/184 (23%), Positives = 81/184 (44%), Gaps = 28/184 (15%)
Query: 21 EELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQ----------- 69
EE RQ + ++ +E L+A+ A L E A Q A L++ +E Q
Sbjct: 2002 EEAARQRKAALEEVERLKAKVEE-ARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHA 2059
Query: 70 -VVSHSLEAIELGLGEAQVLL------ALSAHVGALEAEKQRLRSQARRLAQENVWLREE 122
V + ++ L + Q +L A +A A EAE+ R++++ R AQ R +
Sbjct: 2060 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE-REAAQS----RRQ 2114
Query: 123 LEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEE 182
+EE +R +++EE + + E L + + + +Q ++ R+ A +E
Sbjct: 2115 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD---AEM 2171
Query: 183 EERK 186
E+ K
Sbjct: 2172 EKHK 2175
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 48.5 bits (114), Expect = 1e-05
Identities = 108/474 (22%), Positives = 180/474 (37%), Gaps = 54/474 (11%)
Query: 17 RLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGP-----AAGLEMLEEKQQVV 71
+L P + +V G E++ E+ L H +E + L +EE++++
Sbjct: 1292 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA 1351
Query: 72 SHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLR 131
L E + ALE ++Q + A+ AQ +E + Q +
Sbjct: 1352 EQQRAEERERLAEVEA---------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 132 ASEESVAQLEEEKRHL-EFLGQLRQ---YDPPAESQQSESPPRRDSLASLFPSEEEERKG 187
EE+ +++KR + E L QLRQ + A+++Q+E+ R S EEE R
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER-----SRLRIEEEIRVV 1457
Query: 188 PEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGR--YEVAVPLCRQALEDLERSSGHCH 245
A Q+GG E L+ L + Q R E A L RQ ++ +R
Sbjct: 1458 RLQLEATERQRGGAE--GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR-QAE 1514
Query: 246 PDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRG 305
++A+ + A R++ + +A + L + E+ L A + V
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQ 1571
Query: 306 RYREAEPLCQRALEIR-----EKVLGADHPDVAKQLNNLALLCQNQGKF----EDVERHY 356
R EAE +RA E+ L +H VA+ Q Q + E+ ER
Sbjct: 1572 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL 1631
Query: 357 AR-ALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKE-------ILHKEDLP 408
R L EAL + +LA A ++ K + E + + +E
Sbjct: 1632 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1691
Query: 409 APLGAPNTGTAGDAEQALRRSSSLSKIRESIRRGS------EKLVSRLRGEAAA 456
L G A+Q L L ++R +G E+ ++RL+ EAAA
Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745
Score = 43.5 bits (101), Expect = 4e-04
Identities = 109/470 (23%), Positives = 170/470 (36%), Gaps = 54/470 (11%)
Query: 12 GLGPERLSPE-ELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQV 70
G +RL+ E EL+R + QG + + LA EA A +K+Q
Sbjct: 1703 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT----------QKRQE 1752
Query: 71 VSHSLEAIELGLGEAQVLLALSAHV-----GALEAEKQRLRSQA---RRLAQENVWLREE 122
+ L + E +VLLA A E KQRL ++A R LA+E LR
Sbjct: 1753 LEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1809
Query: 123 LEETQRRLRASEESVAQLEEEKRH-----LEFLGQLRQYDPPAESQQSESPPRRDSLASL 177
EE +R+ + +EE A+ E L +G+ + AE E + L L
Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869
Query: 178 FPSEEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDL 237
E +R+ E A Q +I RL L A E L +ED
Sbjct: 1870 AEDEAFQRRRLEEQAA----QHKADIEERLAQLRK-----ASDSELERQKGL----VEDT 1916
Query: 238 ERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIR---EQTLGPEHPAVAATL 294
R + ILAL + +L + +IR E TL + A
Sbjct: 1917 LRQRRQVEEE------ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970
Query: 295 NNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKF-EDVE 353
+ + R REAE Q++L E+ +++ L + + E E
Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEA-ARQRKAALEEVERLKAKVEEARRLRERAE 2029
Query: 354 RHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGA 413
+ AR L + A A+ K + + K+ + QQ + + +L + A
Sbjct: 2030 QESARQLQL--AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2087
Query: 414 PNTGTAGDAE-QALRRSSSLSKIRESIRRGSEKLVSRLRGEAAAGAAGMK 462
A +A QA R ++ + E R + + + A A AA K
Sbjct: 2088 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Score = 36.6 bits (83), Expect = 0.055
Identities = 64/254 (25%), Positives = 98/254 (38%), Gaps = 23/254 (9%)
Query: 16 ERL--SPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAG---QGPAAGLEMLEEKQ-- 68
ERL S EE + Q E LR E A A+A Q AA EM + K+
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174
Query: 69 QVVSHSLEAIELGLGEAQVLLALSAHV-GALEAEKQRLRSQARRLAQENVWLREELEETQ 127
+ +E L ++ L + H L+ E QRL+++A A++ + EEL +
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 128 RRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEERKG 187
++ + A++E E R L LR D Q E+ + +EE R
Sbjct: 2235 VQMEELSKLKARIEAENRAL----ILRDKDNTQRFLQEEAEKMKQ------VAEEAARLS 2284
Query: 188 PEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQG-----RYEVAVPLCRQALEDLERSSG 242
A AA +Q E A+ R L +++ Q R + L +Q E + +
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2344
Query: 243 HCHPDVATMLNILA 256
D M LA
Sbjct: 2345 RLQEDKEQMAQQLA 2358
Score = 34.7 bits (78), Expect = 0.21
Identities = 43/164 (26%), Positives = 69/164 (42%), Gaps = 11/164 (6%)
Query: 22 ELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSLEAIELG 81
EL R+ ++ Q + L+ + + E L + A L EK ++ +
Sbjct: 2454 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2513
Query: 82 LGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEESVAQLE 141
Q+ A L E+QR Q +++ QE L +EE +RR +EE V + +
Sbjct: 2514 AKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570
Query: 142 EEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEER 185
EE + LE Q RQ + E E+ R+ L L EE+ R
Sbjct: 2571 EELQQLE--QQRRQQE---ELLAEENQRLREQLQLL---EEQHR 2606
Score = 32.3 bits (72), Expect = 1.0
Identities = 38/140 (27%), Positives = 56/140 (40%), Gaps = 10/140 (7%)
Query: 66 EKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQ--RLRSQARRLAQENVWLREEL 123
E+Q V L EL E Q LA L AE++ RLR++ + Q+ L EEL
Sbjct: 1680 EEQAVRQRELAEQEL---EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736
Query: 124 EETQRRLRASEESVAQLEEEKRHLE-----FLGQLRQYDPPAESQQSESPPRRDSLASLF 178
QR A+ + +LE E + L + + + S +S R ++ A F
Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1796
Query: 179 PSEEEERKGPEAAGAAAAQQ 198
EE A A +Q
Sbjct: 1797 RELAEEAARLRALAEEAKRQ 1816
Score = 30.8 bits (68), Expect = 3.0
Identities = 41/144 (28%), Positives = 58/144 (40%), Gaps = 11/144 (7%)
Query: 3 VQVAAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAA--- 59
++V A E S E +Q + G AE LAE Q A
Sbjct: 1764 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1823
Query: 60 GLEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWL 119
E ++V++ L AI GEA L A + E E + R RRLA++ +
Sbjct: 1824 AARQRAEAERVLAEKLAAI----GEA-TRLKTEAEIALKEKEAENER--LRRLAEDEAFQ 1876
Query: 120 REELEETQRRLRAS-EESVAQLEE 142
R LEE + +A EE +AQL +
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRK 1900
Score = 30.0 bits (66), Expect = 5.1
Identities = 44/184 (23%), Positives = 81/184 (44%), Gaps = 28/184 (15%)
Query: 21 EELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQ----------- 69
EE RQ + ++ +E L+A+ A L E A Q A L++ +E Q
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEE-ARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHA 2055
Query: 70 -VVSHSLEAIELGLGEAQVLL------ALSAHVGALEAEKQRLRSQARRLAQENVWLREE 122
V + ++ L + Q +L A +A A EAE+ R++++ R AQ R +
Sbjct: 2056 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE-REAAQS----RRQ 2110
Query: 123 LEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEE 182
+EE +R +++EE + + E L + + + +Q ++ R+ A +E
Sbjct: 2111 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD---AEM 2167
Query: 183 EERK 186
E+ K
Sbjct: 2168 EKHK 2171
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 48.5 bits (114), Expect = 1e-05
Identities = 108/474 (22%), Positives = 180/474 (37%), Gaps = 54/474 (11%)
Query: 17 RLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGP-----AAGLEMLEEKQQVV 71
+L P + +V G E++ E+ L H +E + L +EE++++
Sbjct: 1260 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA 1319
Query: 72 SHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLR 131
L E + ALE ++Q + A+ AQ +E + Q +
Sbjct: 1320 EQQRAEERERLAEVEA---------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370
Query: 132 ASEESVAQLEEEKRHL-EFLGQLRQ---YDPPAESQQSESPPRRDSLASLFPSEEEERKG 187
EE+ +++KR + E L QLRQ + A+++Q+E+ R S EEE R
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER-----SRLRIEEEIRVV 1425
Query: 188 PEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGR--YEVAVPLCRQALEDLERSSGHCH 245
A Q+GG E L+ L + Q R E A L RQ ++ +R
Sbjct: 1426 RLQLEATERQRGGAE--GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR-QAE 1482
Query: 246 PDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRG 305
++A+ + A R++ + +A + L + E+ L A + V
Sbjct: 1483 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQ 1539
Query: 306 RYREAEPLCQRALEIR-----EKVLGADHPDVAKQLNNLALLCQNQGKF----EDVERHY 356
R EAE +RA E+ L +H VA+ Q Q + E+ ER
Sbjct: 1540 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL 1599
Query: 357 AR-ALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKE-------ILHKEDLP 408
R L EAL + +LA A ++ K + E + + +E
Sbjct: 1600 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1659
Query: 409 APLGAPNTGTAGDAEQALRRSSSLSKIRESIRRGS------EKLVSRLRGEAAA 456
L G A+Q L L ++R +G E+ ++RL+ EAAA
Sbjct: 1660 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1713
Score = 43.5 bits (101), Expect = 4e-04
Identities = 109/470 (23%), Positives = 170/470 (36%), Gaps = 54/470 (11%)
Query: 12 GLGPERLSPE-ELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQV 70
G +RL+ E EL+R + QG + + LA EA A +K+Q
Sbjct: 1671 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT----------QKRQE 1720
Query: 71 VSHSLEAIELGLGEAQVLLALSAHV-----GALEAEKQRLRSQA---RRLAQENVWLREE 122
+ L + E +VLLA A E KQRL ++A R LA+E LR
Sbjct: 1721 LEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1777
Query: 123 LEETQRRLRASEESVAQLEEEKRH-----LEFLGQLRQYDPPAESQQSESPPRRDSLASL 177
EE +R+ + +EE A+ E L +G+ + AE E + L L
Sbjct: 1778 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1837
Query: 178 FPSEEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDL 237
E +R+ E A Q +I RL L A E L +ED
Sbjct: 1838 AEDEAFQRRRLEEQAA----QHKADIEERLAQLRK-----ASDSELERQKGL----VEDT 1884
Query: 238 ERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIR---EQTLGPEHPAVAATL 294
R + ILAL + +L + +IR E TL + A
Sbjct: 1885 LRQRRQVEEE------ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1938
Query: 295 NNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKF-EDVE 353
+ + R REAE Q++L E+ +++ L + + E E
Sbjct: 1939 RQRQLAAEEERRRREAEERVQKSLAAEEEA-ARQRKAALEEVERLKAKVEEARRLRERAE 1997
Query: 354 RHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGA 413
+ AR L + A A+ K + + K+ + QQ + + +L + A
Sbjct: 1998 QESARQLQL--AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2055
Query: 414 PNTGTAGDAE-QALRRSSSLSKIRESIRRGSEKLVSRLRGEAAAGAAGMK 462
A +A QA R ++ + E R + + + A A AA K
Sbjct: 2056 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2105
Score = 36.6 bits (83), Expect = 0.055
Identities = 64/254 (25%), Positives = 98/254 (38%), Gaps = 23/254 (9%)
Query: 16 ERL--SPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAG---QGPAAGLEMLEEKQ-- 68
ERL S EE + Q E LR E A A+A Q AA EM + K+
Sbjct: 2083 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2142
Query: 69 QVVSHSLEAIELGLGEAQVLLALSAHV-GALEAEKQRLRSQARRLAQENVWLREELEETQ 127
+ +E L ++ L + H L+ E QRL+++A A++ + EEL +
Sbjct: 2143 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2202
Query: 128 RRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEERKG 187
++ + A++E E R L LR D Q E+ + +EE R
Sbjct: 2203 VQMEELSKLKARIEAENRAL----ILRDKDNTQRFLQEEAEKMKQ------VAEEAARLS 2252
Query: 188 PEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQG-----RYEVAVPLCRQALEDLERSSG 242
A AA +Q E A+ R L +++ Q R + L +Q E + +
Sbjct: 2253 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2312
Query: 243 HCHPDVATMLNILA 256
D M LA
Sbjct: 2313 RLQEDKEQMAQQLA 2326
Score = 34.7 bits (78), Expect = 0.21
Identities = 43/164 (26%), Positives = 69/164 (42%), Gaps = 11/164 (6%)
Query: 22 ELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSLEAIELG 81
EL R+ ++ Q + L+ + + E L + A L EK ++ +
Sbjct: 2422 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2481
Query: 82 LGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEESVAQLE 141
Q+ A L E+QR Q +++ QE L +EE +RR +EE V + +
Sbjct: 2482 AKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2538
Query: 142 EEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEER 185
EE + LE Q RQ + E E+ R+ L L EE+ R
Sbjct: 2539 EELQQLE--QQRRQQE---ELLAEENQRLREQLQLL---EEQHR 2574
Score = 32.3 bits (72), Expect = 1.0
Identities = 38/140 (27%), Positives = 56/140 (40%), Gaps = 10/140 (7%)
Query: 66 EKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQ--RLRSQARRLAQENVWLREEL 123
E+Q V L EL E Q LA L AE++ RLR++ + Q+ L EEL
Sbjct: 1648 EEQAVRQRELAEQEL---EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1704
Query: 124 EETQRRLRASEESVAQLEEEKRHLE-----FLGQLRQYDPPAESQQSESPPRRDSLASLF 178
QR A+ + +LE E + L + + + S +S R ++ A F
Sbjct: 1705 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1764
Query: 179 PSEEEERKGPEAAGAAAAQQ 198
EE A A +Q
Sbjct: 1765 RELAEEAARLRALAEEAKRQ 1784
Score = 30.8 bits (68), Expect = 3.0
Identities = 41/144 (28%), Positives = 58/144 (40%), Gaps = 11/144 (7%)
Query: 3 VQVAAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAA--- 59
++V A E S E +Q + G AE LAE Q A
Sbjct: 1732 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1791
Query: 60 GLEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWL 119
E ++V++ L AI GEA L A + E E + R RRLA++ +
Sbjct: 1792 AARQRAEAERVLAEKLAAI----GEA-TRLKTEAEIALKEKEAENER--LRRLAEDEAFQ 1844
Query: 120 REELEETQRRLRAS-EESVAQLEE 142
R LEE + +A EE +AQL +
Sbjct: 1845 RRRLEEQAAQHKADIEERLAQLRK 1868
Score = 30.0 bits (66), Expect = 5.1
Identities = 44/184 (23%), Positives = 81/184 (44%), Gaps = 28/184 (15%)
Query: 21 EELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQ----------- 69
EE RQ + ++ +E L+A+ A L E A Q A L++ +E Q
Sbjct: 1966 EEAARQRKAALEEVERLKAKVEE-ARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHA 2023
Query: 70 -VVSHSLEAIELGLGEAQVLL------ALSAHVGALEAEKQRLRSQARRLAQENVWLREE 122
V + ++ L + Q +L A +A A EAE+ R++++ R AQ R +
Sbjct: 2024 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE-REAAQS----RRQ 2078
Query: 123 LEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEE 182
+EE +R +++EE + + E L + + + +Q ++ R+ A +E
Sbjct: 2079 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD---AEM 2135
Query: 183 EERK 186
E+ K
Sbjct: 2136 EKHK 2139
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 48.5 bits (114), Expect = 1e-05
Identities = 108/474 (22%), Positives = 180/474 (37%), Gaps = 54/474 (11%)
Query: 17 RLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGP-----AAGLEMLEEKQQVV 71
+L P + +V G E++ E+ L H +E + L +EE++++
Sbjct: 1429 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA 1488
Query: 72 SHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLR 131
L E + ALE ++Q + A+ AQ +E + Q +
Sbjct: 1489 EQQRAEERERLAEVEA---------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539
Query: 132 ASEESVAQLEEEKRHL-EFLGQLRQ---YDPPAESQQSESPPRRDSLASLFPSEEEERKG 187
EE+ +++KR + E L QLRQ + A+++Q+E+ R S EEE R
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER-----SRLRIEEEIRVV 1594
Query: 188 PEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGR--YEVAVPLCRQALEDLERSSGHCH 245
A Q+GG E L+ L + Q R E A L RQ ++ +R
Sbjct: 1595 RLQLEATERQRGGAE--GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR-QAE 1651
Query: 246 PDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRG 305
++A+ + A R++ + +A + L + E+ L A + V
Sbjct: 1652 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQ 1708
Query: 306 RYREAEPLCQRALEIR-----EKVLGADHPDVAKQLNNLALLCQNQGKF----EDVERHY 356
R EAE +RA E+ L +H VA+ Q Q + E+ ER
Sbjct: 1709 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL 1768
Query: 357 AR-ALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKE-------ILHKEDLP 408
R L EAL + +LA A ++ K + E + + +E
Sbjct: 1769 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1828
Query: 409 APLGAPNTGTAGDAEQALRRSSSLSKIRESIRRGS------EKLVSRLRGEAAA 456
L G A+Q L L ++R +G E+ ++RL+ EAAA
Sbjct: 1829 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1882
Score = 43.5 bits (101), Expect = 4e-04
Identities = 109/470 (23%), Positives = 170/470 (36%), Gaps = 54/470 (11%)
Query: 12 GLGPERLSPE-ELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQV 70
G +RL+ E EL+R + QG + + LA EA A +K+Q
Sbjct: 1840 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT----------QKRQE 1889
Query: 71 VSHSLEAIELGLGEAQVLLALSAHV-----GALEAEKQRLRSQA---RRLAQENVWLREE 122
+ L + E +VLLA A E KQRL ++A R LA+E LR
Sbjct: 1890 LEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1946
Query: 123 LEETQRRLRASEESVAQLEEEKRH-----LEFLGQLRQYDPPAESQQSESPPRRDSLASL 177
EE +R+ + +EE A+ E L +G+ + AE E + L L
Sbjct: 1947 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 2006
Query: 178 FPSEEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDL 237
E +R+ E A Q +I RL L A E L +ED
Sbjct: 2007 AEDEAFQRRRLEEQAA----QHKADIEERLAQLRK-----ASDSELERQKGL----VEDT 2053
Query: 238 ERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIR---EQTLGPEHPAVAATL 294
R + ILAL + +L + +IR E TL + A
Sbjct: 2054 LRQRRQVEEE------ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 2107
Query: 295 NNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKF-EDVE 353
+ + R REAE Q++L E+ +++ L + + E E
Sbjct: 2108 RQRQLAAEEERRRREAEERVQKSLAAEEEA-ARQRKAALEEVERLKAKVEEARRLRERAE 2166
Query: 354 RHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGA 413
+ AR L + A A+ K + + K+ + QQ + + +L + A
Sbjct: 2167 QESARQLQL--AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2224
Query: 414 PNTGTAGDAE-QALRRSSSLSKIRESIRRGSEKLVSRLRGEAAAGAAGMK 462
A +A QA R ++ + E R + + + A A AA K
Sbjct: 2225 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2274
Score = 36.6 bits (83), Expect = 0.055
Identities = 64/254 (25%), Positives = 98/254 (38%), Gaps = 23/254 (9%)
Query: 16 ERL--SPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAG---QGPAAGLEMLEEKQ-- 68
ERL S EE + Q E LR E A A+A Q AA EM + K+
Sbjct: 2252 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2311
Query: 69 QVVSHSLEAIELGLGEAQVLLALSAHV-GALEAEKQRLRSQARRLAQENVWLREELEETQ 127
+ +E L ++ L + H L+ E QRL+++A A++ + EEL +
Sbjct: 2312 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2371
Query: 128 RRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEERKG 187
++ + A++E E R L LR D Q E+ + +EE R
Sbjct: 2372 VQMEELSKLKARIEAENRAL----ILRDKDNTQRFLQEEAEKMKQ------VAEEAARLS 2421
Query: 188 PEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQG-----RYEVAVPLCRQALEDLERSSG 242
A AA +Q E A+ R L +++ Q R + L +Q E + +
Sbjct: 2422 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2481
Query: 243 HCHPDVATMLNILA 256
D M LA
Sbjct: 2482 RLQEDKEQMAQQLA 2495
Score = 34.7 bits (78), Expect = 0.21
Identities = 43/164 (26%), Positives = 69/164 (42%), Gaps = 11/164 (6%)
Query: 22 ELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSLEAIELG 81
EL R+ ++ Q + L+ + + E L + A L EK ++ +
Sbjct: 2591 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2650
Query: 82 LGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEESVAQLE 141
Q+ A L E+QR Q +++ QE L +EE +RR +EE V + +
Sbjct: 2651 AKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2707
Query: 142 EEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEER 185
EE + LE Q RQ + E E+ R+ L L EE+ R
Sbjct: 2708 EELQQLE--QQRRQQE---ELLAEENQRLREQLQLL---EEQHR 2743
Score = 32.3 bits (72), Expect = 1.0
Identities = 38/140 (27%), Positives = 56/140 (40%), Gaps = 10/140 (7%)
Query: 66 EKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQ--RLRSQARRLAQENVWLREEL 123
E+Q V L EL E Q LA L AE++ RLR++ + Q+ L EEL
Sbjct: 1817 EEQAVRQRELAEQEL---EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1873
Query: 124 EETQRRLRASEESVAQLEEEKRHLE-----FLGQLRQYDPPAESQQSESPPRRDSLASLF 178
QR A+ + +LE E + L + + + S +S R ++ A F
Sbjct: 1874 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1933
Query: 179 PSEEEERKGPEAAGAAAAQQ 198
EE A A +Q
Sbjct: 1934 RELAEEAARLRALAEEAKRQ 1953
Score = 30.8 bits (68), Expect = 3.0
Identities = 41/144 (28%), Positives = 58/144 (40%), Gaps = 11/144 (7%)
Query: 3 VQVAAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAA--- 59
++V A E S E +Q + G AE LAE Q A
Sbjct: 1901 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1960
Query: 60 GLEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWL 119
E ++V++ L AI GEA L A + E E + R RRLA++ +
Sbjct: 1961 AARQRAEAERVLAEKLAAI----GEA-TRLKTEAEIALKEKEAENER--LRRLAEDEAFQ 2013
Query: 120 REELEETQRRLRAS-EESVAQLEE 142
R LEE + +A EE +AQL +
Sbjct: 2014 RRRLEEQAAQHKADIEERLAQLRK 2037
Score = 30.0 bits (66), Expect = 5.1
Identities = 44/184 (23%), Positives = 81/184 (44%), Gaps = 28/184 (15%)
Query: 21 EELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQ----------- 69
EE RQ + ++ +E L+A+ A L E A Q A L++ +E Q
Sbjct: 2135 EEAARQRKAALEEVERLKAKVEE-ARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHA 2192
Query: 70 -VVSHSLEAIELGLGEAQVLL------ALSAHVGALEAEKQRLRSQARRLAQENVWLREE 122
V + ++ L + Q +L A +A A EAE+ R++++ R AQ R +
Sbjct: 2193 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE-REAAQS----RRQ 2247
Query: 123 LEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEE 182
+EE +R +++EE + + E L + + + +Q ++ R+ A +E
Sbjct: 2248 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD---AEM 2304
Query: 183 EERK 186
E+ K
Sbjct: 2305 EKHK 2308
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 48.5 bits (114), Expect = 1e-05
Identities = 108/474 (22%), Positives = 180/474 (37%), Gaps = 54/474 (11%)
Query: 17 RLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGP-----AAGLEMLEEKQQVV 71
+L P + +V G E++ E+ L H +E + L +EE++++
Sbjct: 1270 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA 1329
Query: 72 SHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLR 131
L E + ALE ++Q + A+ AQ +E + Q +
Sbjct: 1330 EQQRAEERERLAEVEA---------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380
Query: 132 ASEESVAQLEEEKRHL-EFLGQLRQ---YDPPAESQQSESPPRRDSLASLFPSEEEERKG 187
EE+ +++KR + E L QLRQ + A+++Q+E+ R S EEE R
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER-----SRLRIEEEIRVV 1435
Query: 188 PEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGR--YEVAVPLCRQALEDLERSSGHCH 245
A Q+GG E L+ L + Q R E A L RQ ++ +R
Sbjct: 1436 RLQLEATERQRGGAE--GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR-QAE 1492
Query: 246 PDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRG 305
++A+ + A R++ + +A + L + E+ L A + V
Sbjct: 1493 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQ 1549
Query: 306 RYREAEPLCQRALEIR-----EKVLGADHPDVAKQLNNLALLCQNQGKF----EDVERHY 356
R EAE +RA E+ L +H VA+ Q Q + E+ ER
Sbjct: 1550 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL 1609
Query: 357 AR-ALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKE-------ILHKEDLP 408
R L EAL + +LA A ++ K + E + + +E
Sbjct: 1610 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1669
Query: 409 APLGAPNTGTAGDAEQALRRSSSLSKIRESIRRGS------EKLVSRLRGEAAA 456
L G A+Q L L ++R +G E+ ++RL+ EAAA
Sbjct: 1670 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1723
Score = 43.5 bits (101), Expect = 4e-04
Identities = 109/470 (23%), Positives = 170/470 (36%), Gaps = 54/470 (11%)
Query: 12 GLGPERLSPE-ELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQV 70
G +RL+ E EL+R + QG + + LA EA A +K+Q
Sbjct: 1681 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT----------QKRQE 1730
Query: 71 VSHSLEAIELGLGEAQVLLALSAHV-----GALEAEKQRLRSQA---RRLAQENVWLREE 122
+ L + E +VLLA A E KQRL ++A R LA+E LR
Sbjct: 1731 LEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1787
Query: 123 LEETQRRLRASEESVAQLEEEKRH-----LEFLGQLRQYDPPAESQQSESPPRRDSLASL 177
EE +R+ + +EE A+ E L +G+ + AE E + L L
Sbjct: 1788 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1847
Query: 178 FPSEEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDL 237
E +R+ E A Q +I RL L A E L +ED
Sbjct: 1848 AEDEAFQRRRLEEQAA----QHKADIEERLAQLRK-----ASDSELERQKGL----VEDT 1894
Query: 238 ERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIR---EQTLGPEHPAVAATL 294
R + ILAL + +L + +IR E TL + A
Sbjct: 1895 LRQRRQVEEE------ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1948
Query: 295 NNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKF-EDVE 353
+ + R REAE Q++L E+ +++ L + + E E
Sbjct: 1949 RQRQLAAEEERRRREAEERVQKSLAAEEEA-ARQRKAALEEVERLKAKVEEARRLRERAE 2007
Query: 354 RHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGA 413
+ AR L + A A+ K + + K+ + QQ + + +L + A
Sbjct: 2008 QESARQLQL--AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2065
Query: 414 PNTGTAGDAE-QALRRSSSLSKIRESIRRGSEKLVSRLRGEAAAGAAGMK 462
A +A QA R ++ + E R + + + A A AA K
Sbjct: 2066 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2115
Score = 36.6 bits (83), Expect = 0.055
Identities = 64/254 (25%), Positives = 98/254 (38%), Gaps = 23/254 (9%)
Query: 16 ERL--SPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAG---QGPAAGLEMLEEKQ-- 68
ERL S EE + Q E LR E A A+A Q AA EM + K+
Sbjct: 2093 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2152
Query: 69 QVVSHSLEAIELGLGEAQVLLALSAHV-GALEAEKQRLRSQARRLAQENVWLREELEETQ 127
+ +E L ++ L + H L+ E QRL+++A A++ + EEL +
Sbjct: 2153 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2212
Query: 128 RRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEERKG 187
++ + A++E E R L LR D Q E+ + +EE R
Sbjct: 2213 VQMEELSKLKARIEAENRAL----ILRDKDNTQRFLQEEAEKMKQ------VAEEAARLS 2262
Query: 188 PEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQG-----RYEVAVPLCRQALEDLERSSG 242
A AA +Q E A+ R L +++ Q R + L +Q E + +
Sbjct: 2263 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2322
Query: 243 HCHPDVATMLNILA 256
D M LA
Sbjct: 2323 RLQEDKEQMAQQLA 2336
Score = 34.7 bits (78), Expect = 0.21
Identities = 43/164 (26%), Positives = 69/164 (42%), Gaps = 11/164 (6%)
Query: 22 ELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSLEAIELG 81
EL R+ ++ Q + L+ + + E L + A L EK ++ +
Sbjct: 2432 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2491
Query: 82 LGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEESVAQLE 141
Q+ A L E+QR Q +++ QE L +EE +RR +EE V + +
Sbjct: 2492 AKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2548
Query: 142 EEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEER 185
EE + LE Q RQ + E E+ R+ L L EE+ R
Sbjct: 2549 EELQQLE--QQRRQQE---ELLAEENQRLREQLQLL---EEQHR 2584
Score = 32.3 bits (72), Expect = 1.0
Identities = 38/140 (27%), Positives = 56/140 (40%), Gaps = 10/140 (7%)
Query: 66 EKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQ--RLRSQARRLAQENVWLREEL 123
E+Q V L EL E Q LA L AE++ RLR++ + Q+ L EEL
Sbjct: 1658 EEQAVRQRELAEQEL---EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1714
Query: 124 EETQRRLRASEESVAQLEEEKRHLE-----FLGQLRQYDPPAESQQSESPPRRDSLASLF 178
QR A+ + +LE E + L + + + S +S R ++ A F
Sbjct: 1715 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1774
Query: 179 PSEEEERKGPEAAGAAAAQQ 198
EE A A +Q
Sbjct: 1775 RELAEEAARLRALAEEAKRQ 1794
Score = 30.8 bits (68), Expect = 3.0
Identities = 41/144 (28%), Positives = 58/144 (40%), Gaps = 11/144 (7%)
Query: 3 VQVAAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAA--- 59
++V A E S E +Q + G AE LAE Q A
Sbjct: 1742 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1801
Query: 60 GLEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWL 119
E ++V++ L AI GEA L A + E E + R RRLA++ +
Sbjct: 1802 AARQRAEAERVLAEKLAAI----GEA-TRLKTEAEIALKEKEAENER--LRRLAEDEAFQ 1854
Query: 120 REELEETQRRLRAS-EESVAQLEE 142
R LEE + +A EE +AQL +
Sbjct: 1855 RRRLEEQAAQHKADIEERLAQLRK 1878
Score = 30.0 bits (66), Expect = 5.1
Identities = 44/184 (23%), Positives = 81/184 (44%), Gaps = 28/184 (15%)
Query: 21 EELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQ----------- 69
EE RQ + ++ +E L+A+ A L E A Q A L++ +E Q
Sbjct: 1976 EEAARQRKAALEEVERLKAKVEE-ARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHA 2033
Query: 70 -VVSHSLEAIELGLGEAQVLL------ALSAHVGALEAEKQRLRSQARRLAQENVWLREE 122
V + ++ L + Q +L A +A A EAE+ R++++ R AQ R +
Sbjct: 2034 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE-REAAQS----RRQ 2088
Query: 123 LEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEE 182
+EE +R +++EE + + E L + + + +Q ++ R+ A +E
Sbjct: 2089 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD---AEM 2145
Query: 183 EERK 186
E+ K
Sbjct: 2146 EKHK 2149
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 48.5 bits (114), Expect = 1e-05
Identities = 108/474 (22%), Positives = 180/474 (37%), Gaps = 54/474 (11%)
Query: 17 RLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGP-----AAGLEMLEEKQQVV 71
+L P + +V G E++ E+ L H +E + L +EE++++
Sbjct: 1278 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA 1337
Query: 72 SHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLR 131
L E + ALE ++Q + A+ AQ +E + Q +
Sbjct: 1338 EQQRAEERERLAEVEA---------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388
Query: 132 ASEESVAQLEEEKRHL-EFLGQLRQ---YDPPAESQQSESPPRRDSLASLFPSEEEERKG 187
EE+ +++KR + E L QLRQ + A+++Q+E+ R S EEE R
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER-----SRLRIEEEIRVV 1443
Query: 188 PEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGR--YEVAVPLCRQALEDLERSSGHCH 245
A Q+GG E L+ L + Q R E A L RQ ++ +R
Sbjct: 1444 RLQLEATERQRGGAE--GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR-QAE 1500
Query: 246 PDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRG 305
++A+ + A R++ + +A + L + E+ L A + V
Sbjct: 1501 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQ 1557
Query: 306 RYREAEPLCQRALEIR-----EKVLGADHPDVAKQLNNLALLCQNQGKF----EDVERHY 356
R EAE +RA E+ L +H VA+ Q Q + E+ ER
Sbjct: 1558 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL 1617
Query: 357 AR-ALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKE-------ILHKEDLP 408
R L EAL + +LA A ++ K + E + + +E
Sbjct: 1618 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1677
Query: 409 APLGAPNTGTAGDAEQALRRSSSLSKIRESIRRGS------EKLVSRLRGEAAA 456
L G A+Q L L ++R +G E+ ++RL+ EAAA
Sbjct: 1678 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1731
Score = 43.5 bits (101), Expect = 4e-04
Identities = 109/470 (23%), Positives = 170/470 (36%), Gaps = 54/470 (11%)
Query: 12 GLGPERLSPE-ELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQV 70
G +RL+ E EL+R + QG + + LA EA A +K+Q
Sbjct: 1689 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT----------QKRQE 1738
Query: 71 VSHSLEAIELGLGEAQVLLALSAHV-----GALEAEKQRLRSQA---RRLAQENVWLREE 122
+ L + E +VLLA A E KQRL ++A R LA+E LR
Sbjct: 1739 LEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1795
Query: 123 LEETQRRLRASEESVAQLEEEKRH-----LEFLGQLRQYDPPAESQQSESPPRRDSLASL 177
EE +R+ + +EE A+ E L +G+ + AE E + L L
Sbjct: 1796 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1855
Query: 178 FPSEEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDL 237
E +R+ E A Q +I RL L A E L +ED
Sbjct: 1856 AEDEAFQRRRLEEQAA----QHKADIEERLAQLRK-----ASDSELERQKGL----VEDT 1902
Query: 238 ERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIR---EQTLGPEHPAVAATL 294
R + ILAL + +L + +IR E TL + A
Sbjct: 1903 LRQRRQVEEE------ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1956
Query: 295 NNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKF-EDVE 353
+ + R REAE Q++L E+ +++ L + + E E
Sbjct: 1957 RQRQLAAEEERRRREAEERVQKSLAAEEEA-ARQRKAALEEVERLKAKVEEARRLRERAE 2015
Query: 354 RHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGA 413
+ AR L + A A+ K + + K+ + QQ + + +L + A
Sbjct: 2016 QESARQLQL--AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2073
Query: 414 PNTGTAGDAE-QALRRSSSLSKIRESIRRGSEKLVSRLRGEAAAGAAGMK 462
A +A QA R ++ + E R + + + A A AA K
Sbjct: 2074 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2123
Score = 36.6 bits (83), Expect = 0.055
Identities = 64/254 (25%), Positives = 98/254 (38%), Gaps = 23/254 (9%)
Query: 16 ERL--SPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAG---QGPAAGLEMLEEKQ-- 68
ERL S EE + Q E LR E A A+A Q AA EM + K+
Sbjct: 2101 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2160
Query: 69 QVVSHSLEAIELGLGEAQVLLALSAHV-GALEAEKQRLRSQARRLAQENVWLREELEETQ 127
+ +E L ++ L + H L+ E QRL+++A A++ + EEL +
Sbjct: 2161 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2220
Query: 128 RRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEERKG 187
++ + A++E E R L LR D Q E+ + +EE R
Sbjct: 2221 VQMEELSKLKARIEAENRAL----ILRDKDNTQRFLQEEAEKMKQ------VAEEAARLS 2270
Query: 188 PEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQG-----RYEVAVPLCRQALEDLERSSG 242
A AA +Q E A+ R L +++ Q R + L +Q E + +
Sbjct: 2271 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2330
Query: 243 HCHPDVATMLNILA 256
D M LA
Sbjct: 2331 RLQEDKEQMAQQLA 2344
Score = 34.7 bits (78), Expect = 0.21
Identities = 43/164 (26%), Positives = 69/164 (42%), Gaps = 11/164 (6%)
Query: 22 ELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSLEAIELG 81
EL R+ ++ Q + L+ + + E L + A L EK ++ +
Sbjct: 2440 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2499
Query: 82 LGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEESVAQLE 141
Q+ A L E+QR Q +++ QE L +EE +RR +EE V + +
Sbjct: 2500 AKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2556
Query: 142 EEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEER 185
EE + LE Q RQ + E E+ R+ L L EE+ R
Sbjct: 2557 EELQQLE--QQRRQQE---ELLAEENQRLREQLQLL---EEQHR 2592
Score = 32.3 bits (72), Expect = 1.0
Identities = 38/140 (27%), Positives = 56/140 (40%), Gaps = 10/140 (7%)
Query: 66 EKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQ--RLRSQARRLAQENVWLREEL 123
E+Q V L EL E Q LA L AE++ RLR++ + Q+ L EEL
Sbjct: 1666 EEQAVRQRELAEQEL---EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1722
Query: 124 EETQRRLRASEESVAQLEEEKRHLE-----FLGQLRQYDPPAESQQSESPPRRDSLASLF 178
QR A+ + +LE E + L + + + S +S R ++ A F
Sbjct: 1723 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1782
Query: 179 PSEEEERKGPEAAGAAAAQQ 198
EE A A +Q
Sbjct: 1783 RELAEEAARLRALAEEAKRQ 1802
Score = 30.8 bits (68), Expect = 3.0
Identities = 41/144 (28%), Positives = 58/144 (40%), Gaps = 11/144 (7%)
Query: 3 VQVAAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAA--- 59
++V A E S E +Q + G AE LAE Q A
Sbjct: 1750 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1809
Query: 60 GLEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWL 119
E ++V++ L AI GEA L A + E E + R RRLA++ +
Sbjct: 1810 AARQRAEAERVLAEKLAAI----GEA-TRLKTEAEIALKEKEAENER--LRRLAEDEAFQ 1862
Query: 120 REELEETQRRLRAS-EESVAQLEE 142
R LEE + +A EE +AQL +
Sbjct: 1863 RRRLEEQAAQHKADIEERLAQLRK 1886
Score = 30.0 bits (66), Expect = 5.1
Identities = 44/184 (23%), Positives = 81/184 (44%), Gaps = 28/184 (15%)
Query: 21 EELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQ----------- 69
EE RQ + ++ +E L+A+ A L E A Q A L++ +E Q
Sbjct: 1984 EEAARQRKAALEEVERLKAKVEE-ARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHA 2041
Query: 70 -VVSHSLEAIELGLGEAQVLL------ALSAHVGALEAEKQRLRSQARRLAQENVWLREE 122
V + ++ L + Q +L A +A A EAE+ R++++ R AQ R +
Sbjct: 2042 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE-REAAQS----RRQ 2096
Query: 123 LEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEE 182
+EE +R +++EE + + E L + + + +Q ++ R+ A +E
Sbjct: 2097 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD---AEM 2153
Query: 183 EERK 186
E+ K
Sbjct: 2154 EKHK 2157
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 48.5 bits (114), Expect = 1e-05
Identities = 108/474 (22%), Positives = 180/474 (37%), Gaps = 54/474 (11%)
Query: 17 RLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGP-----AAGLEMLEEKQQVV 71
+L P + +V G E++ E+ L H +E + L +EE++++
Sbjct: 1319 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA 1378
Query: 72 SHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLR 131
L E + ALE ++Q + A+ AQ +E + Q +
Sbjct: 1379 EQQRAEERERLAEVEA---------ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429
Query: 132 ASEESVAQLEEEKRHL-EFLGQLRQ---YDPPAESQQSESPPRRDSLASLFPSEEEERKG 187
EE+ +++KR + E L QLRQ + A+++Q+E+ R S EEE R
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER-----SRLRIEEEIRVV 1484
Query: 188 PEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGR--YEVAVPLCRQALEDLERSSGHCH 245
A Q+GG E L+ L + Q R E A L RQ ++ +R
Sbjct: 1485 RLQLEATERQRGGAE--GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR-QAE 1541
Query: 246 PDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRG 305
++A+ + A R++ + +A + L + E+ L A + V
Sbjct: 1542 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQ 1598
Query: 306 RYREAEPLCQRALEIR-----EKVLGADHPDVAKQLNNLALLCQNQGKF----EDVERHY 356
R EAE +RA E+ L +H VA+ Q Q + E+ ER
Sbjct: 1599 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL 1658
Query: 357 AR-ALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKE-------ILHKEDLP 408
R L EAL + +LA A ++ K + E + + +E
Sbjct: 1659 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1718
Query: 409 APLGAPNTGTAGDAEQALRRSSSLSKIRESIRRGS------EKLVSRLRGEAAA 456
L G A+Q L L ++R +G E+ ++RL+ EAAA
Sbjct: 1719 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1772
Score = 43.5 bits (101), Expect = 4e-04
Identities = 109/470 (23%), Positives = 170/470 (36%), Gaps = 54/470 (11%)
Query: 12 GLGPERLSPE-ELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQV 70
G +RL+ E EL+R + QG + + LA EA A +K+Q
Sbjct: 1730 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT----------QKRQE 1779
Query: 71 VSHSLEAIELGLGEAQVLLALSAHV-----GALEAEKQRLRSQA---RRLAQENVWLREE 122
+ L + E +VLLA A E KQRL ++A R LA+E LR
Sbjct: 1780 LEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1836
Query: 123 LEETQRRLRASEESVAQLEEEKRH-----LEFLGQLRQYDPPAESQQSESPPRRDSLASL 177
EE +R+ + +EE A+ E L +G+ + AE E + L L
Sbjct: 1837 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1896
Query: 178 FPSEEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDL 237
E +R+ E A Q +I RL L A E L +ED
Sbjct: 1897 AEDEAFQRRRLEEQAA----QHKADIEERLAQLRK-----ASDSELERQKGL----VEDT 1943
Query: 238 ERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIR---EQTLGPEHPAVAATL 294
R + ILAL + +L + +IR E TL + A
Sbjct: 1944 LRQRRQVEEE------ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1997
Query: 295 NNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKF-EDVE 353
+ + R REAE Q++L E+ +++ L + + E E
Sbjct: 1998 RQRQLAAEEERRRREAEERVQKSLAAEEEA-ARQRKAALEEVERLKAKVEEARRLRERAE 2056
Query: 354 RHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGA 413
+ AR L + A A+ K + + K+ + QQ + + +L + A
Sbjct: 2057 QESARQLQL--AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2114
Query: 414 PNTGTAGDAE-QALRRSSSLSKIRESIRRGSEKLVSRLRGEAAAGAAGMK 462
A +A QA R ++ + E R + + + A A AA K
Sbjct: 2115 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2164
Score = 36.6 bits (83), Expect = 0.055
Identities = 64/254 (25%), Positives = 98/254 (38%), Gaps = 23/254 (9%)
Query: 16 ERL--SPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAG---QGPAAGLEMLEEKQ-- 68
ERL S EE + Q E LR E A A+A Q AA EM + K+
Sbjct: 2142 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2201
Query: 69 QVVSHSLEAIELGLGEAQVLLALSAHV-GALEAEKQRLRSQARRLAQENVWLREELEETQ 127
+ +E L ++ L + H L+ E QRL+++A A++ + EEL +
Sbjct: 2202 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2261
Query: 128 RRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEERKG 187
++ + A++E E R L LR D Q E+ + +EE R
Sbjct: 2262 VQMEELSKLKARIEAENRAL----ILRDKDNTQRFLQEEAEKMKQ------VAEEAARLS 2311
Query: 188 PEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQG-----RYEVAVPLCRQALEDLERSSG 242
A AA +Q E A+ R L +++ Q R + L +Q E + +
Sbjct: 2312 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2371
Query: 243 HCHPDVATMLNILA 256
D M LA
Sbjct: 2372 RLQEDKEQMAQQLA 2385
Score = 34.7 bits (78), Expect = 0.21
Identities = 43/164 (26%), Positives = 69/164 (42%), Gaps = 11/164 (6%)
Query: 22 ELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSLEAIELG 81
EL R+ ++ Q + L+ + + E L + A L EK ++ +
Sbjct: 2481 ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2540
Query: 82 LGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEESVAQLE 141
Q+ A L E+QR Q +++ QE L +EE +RR +EE V + +
Sbjct: 2541 AKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2597
Query: 142 EEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEER 185
EE + LE Q RQ + E E+ R+ L L EE+ R
Sbjct: 2598 EELQQLE--QQRRQQE---ELLAEENQRLREQLQLL---EEQHR 2633
Score = 32.3 bits (72), Expect = 1.0
Identities = 38/140 (27%), Positives = 56/140 (40%), Gaps = 10/140 (7%)
Query: 66 EKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQ--RLRSQARRLAQENVWLREEL 123
E+Q V L EL E Q LA L AE++ RLR++ + Q+ L EEL
Sbjct: 1707 EEQAVRQRELAEQEL---EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1763
Query: 124 EETQRRLRASEESVAQLEEEKRHLE-----FLGQLRQYDPPAESQQSESPPRRDSLASLF 178
QR A+ + +LE E + L + + + S +S R ++ A F
Sbjct: 1764 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1823
Query: 179 PSEEEERKGPEAAGAAAAQQ 198
EE A A +Q
Sbjct: 1824 RELAEEAARLRALAEEAKRQ 1843
Score = 30.8 bits (68), Expect = 3.0
Identities = 41/144 (28%), Positives = 58/144 (40%), Gaps = 11/144 (7%)
Query: 3 VQVAAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAA--- 59
++V A E S E +Q + G AE LAE Q A
Sbjct: 1791 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1850
Query: 60 GLEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWL 119
E ++V++ L AI GEA L A + E E + R RRLA++ +
Sbjct: 1851 AARQRAEAERVLAEKLAAI----GEA-TRLKTEAEIALKEKEAENER--LRRLAEDEAFQ 1903
Query: 120 REELEETQRRLRAS-EESVAQLEE 142
R LEE + +A EE +AQL +
Sbjct: 1904 RRRLEEQAAQHKADIEERLAQLRK 1927
Score = 30.0 bits (66), Expect = 5.1
Identities = 44/184 (23%), Positives = 81/184 (44%), Gaps = 28/184 (15%)
Query: 21 EELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQ----------- 69
EE RQ + ++ +E L+A+ A L E A Q A L++ +E Q
Sbjct: 2025 EEAARQRKAALEEVERLKAKVEE-ARRLRER-AEQESARQLQLAQEAAQKRLQAEEKAHA 2082
Query: 70 -VVSHSLEAIELGLGEAQVLL------ALSAHVGALEAEKQRLRSQARRLAQENVWLREE 122
V + ++ L + Q +L A +A A EAE+ R++++ R AQ R +
Sbjct: 2083 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE-REAAQS----RRQ 2137
Query: 123 LEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEE 182
+EE +R +++EE + + E L + + + +Q ++ R+ A +E
Sbjct: 2138 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD---AEM 2194
Query: 183 EERK 186
E+ K
Sbjct: 2195 EKHK 2198
>gi|38045919 huntingtin interacting protein 1 [Homo sapiens]
Length = 1037
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/157 (28%), Positives = 74/157 (47%), Gaps = 10/157 (6%)
Query: 22 ELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAG---LEMLEEKQQVVSHSLEAI 78
E+ +Q Q L E L L E ++ QG LE+LE +Q ++ S +
Sbjct: 491 EVTKQVSMARQAQVDLEREKKELEDSL-ERISDQGQRKTQEQLEVLESLKQELATSQREL 549
Query: 79 ELGLGE----AQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASE 134
++ G AQ +A LE E+ L S A +E LR+EL++TQ +L ++E
Sbjct: 550 QVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTE 609
Query: 135 ESVAQLEEEKRHLEFLGQLRQYDPPAES--QQSESPP 169
ES+ QL +++R + +G + + + Q E PP
Sbjct: 610 ESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPP 646
Score = 36.6 bits (83), Expect = 0.055
Identities = 25/63 (39%), Positives = 37/63 (58%), Gaps = 6/63 (9%)
Query: 86 QVLLALSAHVGALE---AEKQRLRSQARRLAQENVWLREELEETQRRLRASEESVAQLEE 142
+V+L L HV LE AE+Q LR QA A + +LR EL+E +R+ +E++ L E
Sbjct: 400 RVVLQLKGHVSELEADLAEQQHLRQQA---ADDCEFLRAELDELRRQREDTEKAQRSLSE 456
Query: 143 EKR 145
+R
Sbjct: 457 IER 459
>gi|81295809 pericentrin [Homo sapiens]
Length = 3336
Score = 47.0 bits (110), Expect = 4e-05
Identities = 43/136 (31%), Positives = 64/136 (47%), Gaps = 18/136 (13%)
Query: 10 SAGLGPERLSPEELVRQTRQ--VVQGLEALRAEHHGLAGHLAEALAGQGPAAGLE-MLEE 66
S L ERL E+L ++T++ V Q +A HH L L E + L+ MLE+
Sbjct: 2758 SEALRHERLLTEQLSQRTQEACVHQDTQA----HHALLQKLKEE---KSRVVDLQAMLEK 2810
Query: 67 KQQVVSHSLEAIELGLG--------EAQVLLALSAHVGALEAEKQRLRSQARRLAQENVW 118
QQ HS + +E E +V L + V AL +K+ LR R ++ W
Sbjct: 2811 VQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAW 2870
Query: 119 LREELEETQRRLRASE 134
L+ ELE++ RL+ E
Sbjct: 2871 LQAELEQSHPRLKEQE 2886
Score = 31.2 bits (69), Expect = 2.3
Identities = 73/316 (23%), Positives = 120/316 (37%), Gaps = 42/316 (13%)
Query: 64 LEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREEL 123
L+ + + SL +E +V+ S+ + L+A + L+ +RL +E E+L
Sbjct: 1683 LDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQL 1742
Query: 124 EETQRRLRASEESVAQLEEEKRHLEFLGQL--RQYDPPAESQQSESPPRRDSLASLFPSE 181
E +E+ + L +G + D A S QSE L S
Sbjct: 1743 HEV-------------IEKLQHELSLMGPVVHEVSDSQAGSLQSE------LLCSQAGGP 1783
Query: 182 EEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSS 241
+ E A A++ + A H+ ++ A Q R + A L +LER+
Sbjct: 1784 RGQALQGELEAALEAKEALSRLLADQERRHSQALE-ALQQRLQGAEEAAELQLAELERNV 1842
Query: 242 GHCHPDVATMLNILALVYRDQNKYKEAT----DLLHDALQIREQTLGPEHPAVAATLNNL 297
+V M + + + K KEAT +L DAL R+ E AV L +
Sbjct: 1843 ALREAEVEDMASRIQ-EFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARI 1901
Query: 298 AVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNL---ALLCQNQGKFEDVER 354
R E +PL A + L A +++QL L L CQ +++R
Sbjct: 1902 R-------RALEQQPLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQ-----VELDR 1949
Query: 355 HYARALSIYEALGGPH 370
AR + + + G H
Sbjct: 1950 RQARRATAHTRVPGAH 1965
Score = 30.0 bits (66), Expect = 5.1
Identities = 40/148 (27%), Positives = 59/148 (39%), Gaps = 29/148 (19%)
Query: 16 ERLSPEELVRQTRQVVQGLEALRAEHHG----------------LAGHLAEALAG--QGP 57
E+L ++ + QT + Q LE L+ +H G LAG +A L G QG
Sbjct: 999 EQLWKKDSLHQTI-LTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQG- 1056
Query: 58 AAGLEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEK-----QRLRSQARRL 112
E EK+ + E + L +AQ +L+ +K Q+L+ Q L
Sbjct: 1057 ----EFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSL 1112
Query: 113 AQENVWLREELEETQRRLRASEESVAQL 140
+ E R ELE Q+R A L
Sbjct: 1113 SHEIEECRSELEVLQQRRERENREGANL 1140
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 46.6 bits (109), Expect = 5e-05
Identities = 71/308 (23%), Positives = 117/308 (37%), Gaps = 53/308 (17%)
Query: 119 LREELEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLF 178
L +EL E +RA A L R ++ L + +QY E Q + +D A
Sbjct: 423 LAQELMEKAIEMRA----YAGLGHAARCMQDLERAKQYH---EQQLGIAEDLKDRAA--- 472
Query: 179 PSEEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQ----YAGQGR------------ 222
E + G +G Y+ +L H + Q YA QGR
Sbjct: 473 -----EGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNAL 527
Query: 223 --YEVAVPLCRQALE-----DLERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDA 275
Y+ AV RQ L+ + S H ++A L R Y+ ++ +
Sbjct: 528 GMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIAREL 587
Query: 276 LQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQ 335
I+ + A L+NL + RG Y +A P ++ L + + D K
Sbjct: 588 RDIQSE---------ARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDL--QDMEGEGKV 636
Query: 336 LNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDP-NVAKTKNNLASAYLKQNKYQQA 394
+NL G +++ ++Y + L++ + L HD + AK NL A+ + +A
Sbjct: 637 CHNLGYAHYCLGNYQEAVKYYEQDLALAKDL---HDKLSQAKAYCNLGLAFKALLNFSKA 693
Query: 395 EELYKEIL 402
EE K +L
Sbjct: 694 EECQKYLL 701
Score = 35.4 bits (80), Expect = 0.12
Identities = 62/279 (22%), Positives = 104/279 (37%), Gaps = 44/279 (15%)
Query: 205 ARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLE---RSSGHCHPDVATMLNILALVYRD 261
A L T + ++ +Y Y Q L DL R+ GH LA VY
Sbjct: 758 AALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGH-----------LAAVYMA 806
Query: 262 QNKYKEATDLLHDALQIREQTLGPEHPA-----VAATLNNLAVLYGKRGRYREAEPLCQR 316
KY A + L + ++ P A + T N+ V+ G + + + Q+
Sbjct: 807 LGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQ 866
Query: 317 ALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDPNVAK 376
L E VL D + NL + G +E+ ++Y + LS+ ++L D AK
Sbjct: 867 -LSGNESVL-----DRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQ--AK 918
Query: 377 TKNNLASAYLKQNKYQQAEELYK----------EILHKEDLPAPLGAPNTGTAGDAEQAL 426
L + + QQA ++ E +K LG+ ++ G+ EQA
Sbjct: 919 AYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHS-QLGNYEQA- 976
Query: 427 RRSSSLSKIRESIRRGSEKLVSRLRGEAAAGAAGMKRAM 465
+S + + + L +AA G G+ + M
Sbjct: 977 -----ISCLERQLNIARDMKDRALESDAACGLGGVYQQM 1010
Score = 31.2 bits (69), Expect = 2.3
Identities = 55/239 (23%), Positives = 90/239 (37%), Gaps = 44/239 (18%)
Query: 202 EIPARLRTLHNLVIQYAGQGRYEVAVPLCRQAL------EDLERSSGHCHPDVATMLNIL 255
+I + R L NL + +G Y A P Q L +D+E CH +
Sbjct: 589 DIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHN--LGYAHYC 646
Query: 256 ALVYRDQNKYKEATDL-----LHDALQIREQ--TLGPEHPAV----------------AA 292
Y++ KY E DL LHD L + LG A+ A
Sbjct: 647 LGNYQEAVKYYEQ-DLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQ 705
Query: 293 TLNNLAVLYGKRGRYREAEPLCQR----ALEIREKVLGADHPDVAKQLNNLALLCQNQG- 347
+LNN + G + +C++ A++ E+ LG H ++L A
Sbjct: 706 SLNNSQAKFRALGNLGDIF-ICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAY 764
Query: 348 ----KFEDVERHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEIL 402
K++ ++ + L +Y+ L P + +LA+ Y+ KY A + Y+E L
Sbjct: 765 RMIQKYDKALGYHTQELEVYQELSDL--PGECRAHGHLAAVYMALGKYTMAFKCYEEQL 821
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.359
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,178,682
Number of Sequences: 37866
Number of extensions: 859229
Number of successful extensions: 6655
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 187
Number of HSP's successfully gapped in prelim test: 403
Number of HSP's that attempted gapping in prelim test: 4730
Number of HSP's gapped (non-prelim): 1877
length of query: 504
length of database: 18,247,518
effective HSP length: 107
effective length of query: 397
effective length of database: 14,195,856
effective search space: 5635754832
effective search space used: 5635754832
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.