Guide to the Human Genome
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Search of human proteins with 90903238

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|90903238 glutathione peroxidase 4 isoform B precursor [Homo
sapiens]
         (227 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|90903238 glutathione peroxidase 4 isoform B precursor [Homo s...   479   e-136
gi|75709200 glutathione peroxidase 4 isoform A precursor [Homo s...   355   2e-98
gi|90903240 glutathione peroxidase 4 isoform C precursor [Homo s...   300   7e-82
gi|15618997 glutathione peroxidase 7 [Homo sapiens]                   108   5e-24
gi|192455698 glutathione peroxidase 8 [Homo sapiens]                   94   7e-20
gi|41406084 glutathione peroxidase 1 isoform 1 [Homo sapiens]          89   4e-18
gi|32967607 glutathione peroxidase 2 [Homo sapiens]                    82   4e-16
gi|6006001 glutathione peroxidase 3 precursor [Homo sapiens]           77   9e-15
gi|33186887 glutathione peroxidase 6 [Homo sapiens]                    67   1e-11
gi|4557629 glutathione peroxidase 5 isoform 1 precursor [Homo sa...    67   2e-11
gi|41406082 glutathione peroxidase 1 isoform 2 [Homo sapiens]          62   4e-10
gi|195539337 S-adenosylhomocysteine hydrolase-like 2 isoform b [...    28   4.9  
gi|24308043 S-adenosylhomocysteine hydrolase-like 2 isoform a [H...    28   4.9  
gi|169210434 PREDICTED: hypothetical protein [Homo sapiens]            28   6.4  
gi|34452173 integrin alpha X precursor [Homo sapiens]                  28   6.4  
gi|194018443 potassium channel tetramerisation domain containing...    28   6.4  
gi|194018441 potassium channel tetramerisation domain containing...    28   6.4  
gi|194018439 potassium channel tetramerisation domain containing...    28   6.4  
gi|16945972 kelch domain containing 3 [Homo sapiens]                   28   6.4  
gi|66472382 nischarin [Homo sapiens]                                   28   8.4  

>gi|90903238 glutathione peroxidase 4 isoform B precursor [Homo
           sapiens]
          Length = 227

 Score =  479 bits (1233), Expect = e-136
 Identities = 227/227 (100%), Positives = 227/227 (100%)

Query: 1   MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR 60
           MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR
Sbjct: 1   MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR 60

Query: 61  GFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA 120
           GFVCIVTNVASQ GKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA
Sbjct: 61  GFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA 120

Query: 121 AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFGHRLSTVPHRQE 180
           AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFGHRLSTVPHRQE
Sbjct: 121 AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFGHRLSTVPHRQE 180

Query: 181 RLRGEALRTHGGAPGDREGPAPLFLAPQVCGPARAPAHALGAFHRHS 227
           RLRGEALRTHGGAPGDREGPAPLFLAPQVCGPARAPAHALGAFHRHS
Sbjct: 181 RLRGEALRTHGGAPGDREGPAPLFLAPQVCGPARAPAHALGAFHRHS 227


>gi|75709200 glutathione peroxidase 4 isoform A precursor [Homo
           sapiens]
          Length = 197

 Score =  355 bits (910), Expect = 2e-98
 Identities = 168/168 (100%), Positives = 168/168 (100%)

Query: 1   MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR 60
           MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR
Sbjct: 1   MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR 60

Query: 61  GFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA 120
           GFVCIVTNVASQ GKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA
Sbjct: 61  GFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA 120

Query: 121 AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKF 168
           AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKF
Sbjct: 121 AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKF 168


>gi|90903240 glutathione peroxidase 4 isoform C precursor [Homo
           sapiens]
          Length = 234

 Score =  300 bits (768), Expect = 7e-82
 Identities = 140/140 (100%), Positives = 140/140 (100%)

Query: 29  CASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHA 88
           CASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQ GKTEVNYTQLVDLHA
Sbjct: 66  CASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHA 125

Query: 89  RYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMK 148
           RYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMK
Sbjct: 126 RYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMK 185

Query: 149 IQPKGKGILGNAIKWNFTKF 168
           IQPKGKGILGNAIKWNFTKF
Sbjct: 186 IQPKGKGILGNAIKWNFTKF 205


>gi|15618997 glutathione peroxidase 7 [Homo sapiens]
          Length = 187

 Score =  108 bits (269), Expect = 5e-24
 Identities = 60/131 (45%), Positives = 80/131 (61%), Gaps = 7/131 (5%)

Query: 39  RSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRIL 98
           +  ++F A +I G +V+L+KYRG V +V NVAS+ G T+ +Y  L  L          +L
Sbjct: 23  QDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFTDQHYRALQQLQRDLGPHHFNVL 82

Query: 99  AFPCNQFGKQEPGSNEEIKEFA-AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGIL 157
           AFPCNQFG+QEP SN+EI+ FA   Y+V F MFSKI V G  AHP +K++  Q  GK   
Sbjct: 83  AFPCNQFGQQEPDSNKEIESFARRTYSVSFPMFSKIAVTGTGAHPAFKYL-AQTSGK--- 138

Query: 158 GNAIKWNFTKF 168
                WNF K+
Sbjct: 139 --EPTWNFWKY 147


>gi|192455698 glutathione peroxidase 8 [Homo sapiens]
          Length = 209

 Score = 94.4 bits (233), Expect = 7e-20
 Identities = 49/130 (37%), Positives = 73/130 (56%), Gaps = 7/130 (5%)

Query: 40  SMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILA 99
           S + F  KD  G  V+L+KY+G V +V NVAS    T+ NY  L +LH  +      +LA
Sbjct: 46  SFYAFEVKDAKGRTVSLEKYKGKVSLVVNVASDCQLTDRNYLGLKELHKEFGPSHFSVLA 105

Query: 100 FPCNQFGKQEPGSNEEIKEFA-AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILG 158
           FPCNQFG+ EP  ++E++ FA   Y V F +F KI + G +  P ++++    K +    
Sbjct: 106 FPCNQFGESEPRPSKEVESFARKNYGVTFPIFHKIKILGSEGEPAFRFLVDSSKKEP--- 162

Query: 159 NAIKWNFTKF 168
              +WNF K+
Sbjct: 163 ---RWNFWKY 169


>gi|41406084 glutathione peroxidase 1 isoform 1 [Homo sapiens]
          Length = 203

 Score = 88.6 bits (218), Expect = 4e-18
 Identities = 66/186 (35%), Positives = 90/186 (48%), Gaps = 26/186 (13%)

Query: 28  MCASR--DDWRCARSMHEFSAKDI-DGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLV 84
           MCA+R       A+S++ FSA+ +  G  V+L   RG V ++ NVAS  G T  +YTQ+ 
Sbjct: 1   MCAARLAAAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTVRDYTQMN 60

Query: 85  DLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEF------AAGYNVKFDMFSKICVNGD 138
           +L  R    GL +L FPCNQFG QE   NEEI           G+   F +F K  VNG 
Sbjct: 61  ELQRRLGPRGLVVLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGA 120

Query: 139 DAHPLWKWMK--------------IQPK---GKGILGNAIKWNFTKFGHRLSTVPHRQER 181
            AHPL+ +++                PK      +  N + WNF KF      VP R+  
Sbjct: 121 GAHPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYS 180

Query: 182 LRGEAL 187
            R + +
Sbjct: 181 RRFQTI 186


>gi|32967607 glutathione peroxidase 2 [Homo sapiens]
          Length = 190

 Score = 82.0 bits (201), Expect = 4e-16
 Identities = 53/154 (34%), Positives = 78/154 (50%), Gaps = 24/154 (15%)

Query: 38  ARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRI 97
           A+S ++ SA  +DG  V+ + +RG   ++ NVAS  G T  ++TQL +L  R+    L +
Sbjct: 5   AKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPR-RLVV 63

Query: 98  LAFPCNQFGKQEPGSNEEIKEF------AAGYNVKFDMFSKICVNGDDAHPLWKWMK--- 148
           L FPCNQFG QE   NEEI           GY   F +  K  VNG + HP++ ++K   
Sbjct: 64  LGFPCNQFGHQENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKL 123

Query: 149 ---------IQPKGKGILGNAIK-----WNFTKF 168
                    +    K I+ + ++     WNF KF
Sbjct: 124 PYPYDDPFSLMTDPKLIIWSPVRRSDVAWNFEKF 157


>gi|6006001 glutathione peroxidase 3 precursor [Homo sapiens]
          Length = 226

 Score = 77.4 bits (189), Expect = 9e-15
 Identities = 61/187 (32%), Positives = 86/187 (45%), Gaps = 25/187 (13%)

Query: 6   LCRLLKPALLCGALAAPGLAGTMCASRDDWRC----ARSMHEFSAKDIDGH-MVNLDKYR 60
           + RLL+ + L   L A  ++ +    +    C    + +++E+ A  IDG   +   +Y 
Sbjct: 1   MARLLQASCLLSLLLAGFVSQSRGQEKSKMDCHGGISGTIYEYGALTIDGEEYIPFKQYA 60

Query: 61  GFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEF- 119
           G   +  NVAS  G T   Y +L  L    A  GL IL FPCNQFGKQEPG N EI    
Sbjct: 61  GKYVLFVNVASYUGLTG-QYIELNALQEELAPFGLVILGFPCNQFGKQEPGENSEILPTL 119

Query: 120 -----AAGYNVKFDMFSKICVNGDDAHPLWKWMKIQ-PKGKGILGNA------------I 161
                  G+   F +F K  VNG+     + ++K   P    +LG +            I
Sbjct: 120 KYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDI 179

Query: 162 KWNFTKF 168
           +WNF KF
Sbjct: 180 RWNFEKF 186


>gi|33186887 glutathione peroxidase 6 [Homo sapiens]
          Length = 221

 Score = 67.4 bits (163), Expect = 1e-11
 Identities = 47/149 (31%), Positives = 74/149 (49%), Gaps = 21/149 (14%)

Query: 40  SMHEFSAKDIDGH-MVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRIL 98
           +++E+ A  ++G   +   ++ G   +  NVA+  G     Y +L  L       G+ +L
Sbjct: 39  TIYEYGALTLNGEEYIQFKQFAGKHVLFVNVAAYUGLA-AQYPELNALQEELKNFGVIVL 97

Query: 99  AFPCNQFGKQEPGSNEEIKEF------AAGYNVKFDMFSKICVNGDDAHPLWKWMKIQ-P 151
           AFPCNQFGKQEPG+N EI          +G+   F +F K  VNG+    ++ ++K   P
Sbjct: 98  AFPCNQFGKQEPGTNSEILLGLKYVCPGSGFVPSFQLFEKGDVNGEKEQKVFTFLKNSCP 157

Query: 152 KGKGILGNA------------IKWNFTKF 168
               +LG++            I+WNF KF
Sbjct: 158 PTSDLLGSSSQLFWEPMKVHDIRWNFEKF 186


>gi|4557629 glutathione peroxidase 5 isoform 1 precursor [Homo
           sapiens]
          Length = 221

 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 47/134 (35%), Positives = 63/134 (47%), Gaps = 20/134 (14%)

Query: 54  VNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSN 113
           V+  +Y G   +  NVA+  G T   Y +L  L       GL +L FPCNQFGKQEPG N
Sbjct: 54  VSFKQYVGKHILFVNVATYCGLT-AQYPELNALQEELKPYGLVVLGFPCNQFGKQEPGDN 112

Query: 114 EEI------KEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQ-PKGKGILG-------- 158
           +EI           G+   F +F K  VNG+    ++ ++K   P    ILG        
Sbjct: 113 KEILPGLKYVRPGGGFVPSFQLFEKGDVNGEKEQKVFSFLKHSCPHPSEILGTFKSISWD 172

Query: 159 ----NAIKWNFTKF 168
               + I+WNF KF
Sbjct: 173 PVKVHDIRWNFEKF 186


>gi|41406082 glutathione peroxidase 1 isoform 2 [Homo sapiens]
          Length = 98

 Score = 62.0 bits (149), Expect = 4e-10
 Identities = 38/84 (45%), Positives = 51/84 (60%), Gaps = 3/84 (3%)

Query: 28  MCASR--DDWRCARSMHEFSAKDI-DGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLV 84
           MCA+R       A+S++ FSA+ +  G  V+L   RG V ++ NVAS  G T  +YTQ+ 
Sbjct: 1   MCAARLAAAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTVRDYTQMN 60

Query: 85  DLHARYAECGLRILAFPCNQFGKQ 108
           +L  R    GL +L FPCNQFG Q
Sbjct: 61  ELQRRLGPRGLVVLGFPCNQFGHQ 84


>gi|195539337 S-adenosylhomocysteine hydrolase-like 2 isoform b
           [Homo sapiens]
          Length = 610

 Score = 28.5 bits (62), Expect = 4.9
 Identities = 14/26 (53%), Positives = 14/26 (53%)

Query: 195 GDREGPAPLFLAPQVCGPARAPAHAL 220
           GD E PAP    P V GP   PA AL
Sbjct: 48  GDPEAPAPAAERPPVPGPGSGPAAAL 73


>gi|24308043 S-adenosylhomocysteine hydrolase-like 2 isoform a [Homo
           sapiens]
          Length = 611

 Score = 28.5 bits (62), Expect = 4.9
 Identities = 14/26 (53%), Positives = 14/26 (53%)

Query: 195 GDREGPAPLFLAPQVCGPARAPAHAL 220
           GD E PAP    P V GP   PA AL
Sbjct: 48  GDPEAPAPAAERPPVPGPGSGPAAAL 73


>gi|169210434 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 301

 Score = 28.1 bits (61), Expect = 6.4
 Identities = 15/31 (48%), Positives = 16/31 (51%), Gaps = 2/31 (6%)

Query: 188 RTHGGAPGD--REGPAPLFLAPQVCGPARAP 216
           R   G  G+  R GPAP  L P VC   RAP
Sbjct: 107 RAQKGGKGEETRRGPAPAGLTPSVCLYGRAP 137


>gi|34452173 integrin alpha X precursor [Homo sapiens]
          Length = 1163

 Score = 28.1 bits (61), Expect = 6.4
 Identities = 11/28 (39%), Positives = 18/28 (64%)

Query: 192 GAPGDREGPAPLFLAPQVCGPARAPAHA 219
           GAPG+ E    ++L   V GP+ +P+H+
Sbjct: 542 GAPGEEENRGAVYLFHGVLGPSISPSHS 569


>gi|194018443 potassium channel tetramerisation domain containing 15
           isoform 2 [Homo sapiens]
          Length = 283

 Score = 28.1 bits (61), Expect = 6.4
 Identities = 13/25 (52%), Positives = 17/25 (68%), Gaps = 1/25 (4%)

Query: 175 VPHRQERLRGEALRTHGGAPGDREG 199
           +PHR+ER  G +L TH G+ G  EG
Sbjct: 1   MPHRKERPSGSSLHTH-GSTGTAEG 24


>gi|194018441 potassium channel tetramerisation domain containing 15
           isoform 2 [Homo sapiens]
          Length = 283

 Score = 28.1 bits (61), Expect = 6.4
 Identities = 13/25 (52%), Positives = 17/25 (68%), Gaps = 1/25 (4%)

Query: 175 VPHRQERLRGEALRTHGGAPGDREG 199
           +PHR+ER  G +L TH G+ G  EG
Sbjct: 1   MPHRKERPSGSSLHTH-GSTGTAEG 24


>gi|194018439 potassium channel tetramerisation domain containing 15
           isoform 1 [Homo sapiens]
          Length = 234

 Score = 28.1 bits (61), Expect = 6.4
 Identities = 13/25 (52%), Positives = 17/25 (68%), Gaps = 1/25 (4%)

Query: 175 VPHRQERLRGEALRTHGGAPGDREG 199
           +PHR+ER  G +L TH G+ G  EG
Sbjct: 1   MPHRKERPSGSSLHTH-GSTGTAEG 24


>gi|16945972 kelch domain containing 3 [Homo sapiens]
          Length = 382

 Score = 28.1 bits (61), Expect = 6.4
 Identities = 19/52 (36%), Positives = 23/52 (44%), Gaps = 17/52 (32%)

Query: 111 GSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWK-------WMKIQPKGKG 155
           G N E+  F  GYN + +            H LWK       W KI+PKGKG
Sbjct: 246 GYNGELYIFG-GYNARLNRHF---------HDLWKFNPVSFTWKKIEPKGKG 287


>gi|66472382 nischarin [Homo sapiens]
          Length = 1504

 Score = 27.7 bits (60), Expect = 8.4
 Identities = 18/49 (36%), Positives = 23/49 (46%), Gaps = 5/49 (10%)

Query: 171  RLSTVPHRQERLRGEALRTHGGAPGDREGPAPLFLAPQVCGPARAPAHA 219
            R ++   R + +  EAL     AP   E PAP   A    GPA+ PA A
Sbjct: 1035 RRASNDQRPQEVPAEAL-----APAPAEVPAPAPAAASASGPAKTPAPA 1078


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.139    0.453 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,959,284
Number of Sequences: 37866
Number of extensions: 461576
Number of successful extensions: 1015
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 994
Number of HSP's gapped (non-prelim): 21
length of query: 227
length of database: 18,247,518
effective HSP length: 99
effective length of query: 128
effective length of database: 14,498,784
effective search space: 1855844352
effective search space used: 1855844352
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 60 (27.7 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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