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Search of human proteins with 14149680
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14149680 extended synaptotagmin-like protein 1 [Homo
sapiens]
(1104 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens] 2202 0.0
gi|45387945 family with sequence similarity 62 (C2 domain contai... 592 e-169
gi|103472031 family with sequence similarity 62 (C2 domain conta... 462 e-130
gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Hom... 102 2e-21
gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Hom... 102 2e-21
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo... 90 1e-17
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom... 90 1e-17
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide... 80 8e-15
gi|154354981 regulating synaptic membrane exocytosis 2 isoform b... 74 6e-13
gi|154354983 regulating synaptic membrane exocytosis 2 isoform a... 70 1e-11
gi|41054864 regulating synaptic membrane exocytosis 1 [Homo sapi... 69 2e-11
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 68 4e-11
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 68 4e-11
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens] 68 4e-11
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens] 68 4e-11
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 68 4e-11
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 68 4e-11
gi|6005997 double C2-like domains, beta [Homo sapiens] 68 4e-11
gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Hom... 67 1e-10
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid... 65 5e-10
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva... 64 8e-10
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva... 64 8e-10
gi|45504376 synaptotagmin VI [Homo sapiens] 64 8e-10
gi|238550198 synaptotagmin III [Homo sapiens] 62 2e-09
gi|238550196 synaptotagmin III [Homo sapiens] 62 2e-09
gi|14150054 synaptotagmin III [Homo sapiens] 62 2e-09
gi|39752671 synaptotagmin X [Homo sapiens] 62 3e-09
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 61 5e-09
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 61 5e-09
gi|47078261 double C2-like domains, alpha [Homo sapiens] 60 1e-08
>gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens]
Length = 1104
Score = 2202 bits (5707), Expect = 0.0
Identities = 1104/1104 (100%), Positives = 1104/1104 (100%)
Query: 1 MERSPGEGPSPSPMDQPSAPSDPTDQPPAAHAKPDPGSGGQPAGPGAAGEALAVLTSFGR 60
MERSPGEGPSPSPMDQPSAPSDPTDQPPAAHAKPDPGSGGQPAGPGAAGEALAVLTSFGR
Sbjct: 1 MERSPGEGPSPSPMDQPSAPSDPTDQPPAAHAKPDPGSGGQPAGPGAAGEALAVLTSFGR 60
Query: 61 RLLVLIPVYLAGAVGLSVGFVLFGLALYLGWRRVRDEKERSLRAARQLLDDEEQLTAKTL 120
RLLVLIPVYLAGAVGLSVGFVLFGLALYLGWRRVRDEKERSLRAARQLLDDEEQLTAKTL
Sbjct: 61 RLLVLIPVYLAGAVGLSVGFVLFGLALYLGWRRVRDEKERSLRAARQLLDDEEQLTAKTL 120
Query: 121 YMSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGSNPHLQTFT 180
YMSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGSNPHLQTFT
Sbjct: 121 YMSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGSNPHLQTFT 180
Query: 181 FTRVELGEKPLRIIGVKVHPGQRKEQILLDLNISYVGDVQIDVEVKKYFCKAGVKGMQLH 240
FTRVELGEKPLRIIGVKVHPGQRKEQILLDLNISYVGDVQIDVEVKKYFCKAGVKGMQLH
Sbjct: 181 FTRVELGEKPLRIIGVKVHPGQRKEQILLDLNISYVGDVQIDVEVKKYFCKAGVKGMQLH 240
Query: 241 GVLRVILEPLIGDLPFVGAVSMFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAA 300
GVLRVILEPLIGDLPFVGAVSMFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAA
Sbjct: 241 GVLRVILEPLIGDLPFVGAVSMFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAA 300
Query: 301 FLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYA 360
FLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYA
Sbjct: 301 FLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYA 360
Query: 361 LVRLGTQTFCSRVIDEELNPQWGETYEVMVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDV 420
LVRLGTQTFCSRVIDEELNPQWGETYEVMVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDV
Sbjct: 361 LVRLGTQTFCSRVIDEELNPQWGETYEVMVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDV 420
Query: 421 GKVLQASVLDDWFPLQGGQGQVHLRLEWLSLLSDAEKLEQVLQWNWGVSSRPDPPSAAIL 480
GKVLQASVLDDWFPLQGGQGQVHLRLEWLSLLSDAEKLEQVLQWNWGVSSRPDPPSAAIL
Sbjct: 421 GKVLQASVLDDWFPLQGGQGQVHLRLEWLSLLSDAEKLEQVLQWNWGVSSRPDPPSAAIL 480
Query: 481 VVYLDRAQDLPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQE 540
VVYLDRAQDLPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQE
Sbjct: 481 VVYLDRAQDLPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQE 540
Query: 541 LDVQVKDDSRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMRILYLDS 600
LDVQVKDDSRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMRILYLDS
Sbjct: 541 LDVQVKDDSRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMRILYLDS 600
Query: 601 SEICFPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHVLRIHVLEAQDLI 660
SEICFPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHVLRIHVLEAQDLI
Sbjct: 601 SEICFPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHVLRIHVLEAQDLI 660
Query: 661 AKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIVTSVPGQELEVEV 720
AKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIVTSVPGQELEVEV
Sbjct: 661 AKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIVTSVPGQELEVEV 720
Query: 721 FDKDLDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLTPRPTAAELEEV 780
FDKDLDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLTPRPTAAELEEV
Sbjct: 721 FDKDLDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLTPRPTAAELEEV 780
Query: 781 LQVNSLIQTQKSAELAAALLSIYMERAEDLPLRKGTKHLSPYATLTVGDSSHKTKTISQT 840
LQVNSLIQTQKSAELAAALLSIYMERAEDLPLRKGTKHLSPYATLTVGDSSHKTKTISQT
Sbjct: 781 LQVNSLIQTQKSAELAAALLSIYMERAEDLPLRKGTKHLSPYATLTVGDSSHKTKTISQT 840
Query: 841 SAPVWDESASFLIRKPHTESLELQVRGEGTGVLGSLSLPLSELLVADQLCLDRWFTLSSG 900
SAPVWDESASFLIRKPHTESLELQVRGEGTGVLGSLSLPLSELLVADQLCLDRWFTLSSG
Sbjct: 841 SAPVWDESASFLIRKPHTESLELQVRGEGTGVLGSLSLPLSELLVADQLCLDRWFTLSSG 900
Query: 901 QGQVLLRAQLGILVSQHSGVEAHSHSYSHSSSSLSEEPELSGGPPHITSSAPELRQRLTH 960
QGQVLLRAQLGILVSQHSGVEAHSHSYSHSSSSLSEEPELSGGPPHITSSAPELRQRLTH
Sbjct: 901 QGQVLLRAQLGILVSQHSGVEAHSHSYSHSSSSLSEEPELSGGPPHITSSAPELRQRLTH 960
Query: 961 VDSPLEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNR 1020
VDSPLEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNR
Sbjct: 961 VDSPLEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNR 1020
Query: 1021 GTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDL 1080
GTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDL
Sbjct: 1021 GTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDL 1080
Query: 1081 AETDLSQGVARWYDLMDNKDKGSS 1104
AETDLSQGVARWYDLMDNKDKGSS
Sbjct: 1081 AETDLSQGVARWYDLMDNKDKGSS 1104
>gi|45387945 family with sequence similarity 62 (C2 domain
containing) member B [Homo sapiens]
Length = 893
Score = 592 bits (1526), Expect = e-169
Identities = 304/609 (49%), Positives = 428/609 (70%), Gaps = 14/609 (2%)
Query: 5 PGEGPSPSPMDQPSAPSDPTDQPPAAHAKPDPGSGGQ-----PAGPGA--AGEALAVLTS 57
PG S P A A P+ G+GG P PG + E +L
Sbjct: 28 PGISASTQPASAGRAARHCGAMSGARGEGPEAGAGGAGGRAAPENPGGVLSVELPGLLAQ 87
Query: 58 FGRRLLVLIPVYLAGAVGLSVGFVLFGLALYLGWRRVRDEKERSLRAARQLLDDEEQLTA 117
R +L+PVY G +GLS +VL LAL RR R K L A LL+DEE++
Sbjct: 88 LARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVR 147
Query: 118 KTLYMSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGSNPHLQ 177
L + +LPAWV FPD E+AEWLNK V +WPF+ Q++EKL ET+ PAVRG+N HL
Sbjct: 148 --LGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLS 205
Query: 178 TFTFTRVELGEKPLRIIGVKVHPGQ-RKEQILLDLNISYVGDVQIDVEVKKYFCKAGVKG 236
TF+FT+V++G++PLRI GVKV+ K QI+LDL IS+VG+ +ID+E+K+YFC+AGVK
Sbjct: 206 TFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKS 265
Query: 237 MQLHGVLRVILEPLIGDLPFVGAVSMFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMD 296
+Q+HG +RVILEPLIGD+P VGA+S+FF+R+P L+INWTG+TNLLD+PGL+ LSDT+I+D
Sbjct: 266 IQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILD 325
Query: 297 SIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKS 356
I+ +LVLPNR+ VPLV ++Q +AQLR P+P+G++RIH + A+ L KD Y+KGL++GKS
Sbjct: 326 IISNYLVLPNRITVPLVSEVQ-IAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKS 384
Query: 357 DPYALVRLGTQTFCSRVIDEELNPQWGETYEVMVHEVPGQEIEVEVFDKDPDKDDFLGRM 416
DPY ++R+G Q F SRVI E L+P+W E YE +V+E PGQE+E+E+FD+DPDKDDFLG +
Sbjct: 385 DPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSL 444
Query: 417 KLDVGKVLQASVLDDWFPL-QGGQGQVHLRLEWLSLLSDAEKLEQVL-QWNWGVSSRPDP 474
+D+ +V + +LD+WF L + +G++HLRLEWL+L+ +A L++VL D
Sbjct: 445 MIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDG 504
Query: 475 PSAAILVVYLDRAQDLPL-KKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFL 533
S+A+L++YLD A++LP KK + PNP+VQ+S+ QESK Y TN PVWEE F FF+
Sbjct: 505 LSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFI 564
Query: 534 QDPQSQELDVQVKDDSRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVM 593
+P+ Q+L+V+V+D+ +LG L +PL++LLT+ ++ + Q FQLS+SGPNS + MK+ +
Sbjct: 565 HNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIAL 624
Query: 594 RILYLDSSE 602
R+L+L+ E
Sbjct: 625 RVLHLEKRE 633
Score = 226 bits (575), Expect = 1e-58
Identities = 123/308 (39%), Positives = 192/308 (62%), Gaps = 5/308 (1%)
Query: 648 VLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVI 707
VLRIH +EAQDL KD +L GLVKGKSDPY +++ + F+S V++E+L+P+WNEV+E +
Sbjct: 358 VLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEAL 417
Query: 708 VTSVPGQELEVEVFDKDLDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLER 767
V PGQELE+E+FD+D DKDDFLG + L V LDEW TL++VP G+LHLRLE
Sbjct: 418 VYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEW 477
Query: 768 LTPRPTAAELEEVLQVNSLIQTQKSAELAAALLSIYMERAEDLPL-RKGTKHLSPYATLT 826
LT P A+ L++VL + Q + L++ALL +Y++ A +LP +K + + +P ++
Sbjct: 478 LTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMS 537
Query: 827 VGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQVRGEGTGV-LGSLSLPLSELLV 885
VG + ++K +T+ PVW+E+ +F I P + LE++VR E LG+L +PLS+LL
Sbjct: 538 VGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLT 597
Query: 886 ADQLCLDRWFTLSSGQGQVLLRAQLGILV---SQHSGVEAHSHSYSHSSSSLSEEPELSG 942
++ + + + F LS+ ++ ++ + V + H HS S+S+E +
Sbjct: 598 SEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTS 657
Query: 943 GPPHITSS 950
H++ S
Sbjct: 658 IKSHMSGS 665
Score = 139 bits (349), Expect = 2e-32
Identities = 74/183 (40%), Positives = 111/183 (60%), Gaps = 9/183 (4%)
Query: 925 HSYSHSSSSLSEEP---ELSGGPPHITS------SAPELRQRLTHVDSPLEAPAGPLGQV 975
H SSSSL P + P I S + ELRQRL +++ PLGQ+
Sbjct: 703 HDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQI 762
Query: 976 KLTLWYYSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTKRRTSQKKRTLSP 1035
+LT+ + S+ KL+ +VH CR+L D DPYV + LLPDK R +R+T K+TL+P
Sbjct: 763 QLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNP 822
Query: 1036 EFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVARWYDL 1095
F++ F++ + L E QRR LDV+VK++ F+S+++ LLGKV + LA +L++G +WYDL
Sbjct: 823 VFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDL 882
Query: 1096 MDN 1098
++
Sbjct: 883 TED 885
>gi|103472031 family with sequence similarity 62 (C2 domain
containing), member C [Homo sapiens]
Length = 886
Score = 462 bits (1189), Expect = e-130
Identities = 260/606 (42%), Positives = 375/606 (61%), Gaps = 42/606 (6%)
Query: 26 QPPAAHAKPDPGSGGQPAGPGA--AGEALAVLTSFGRRLLVLI-PVYLAGAVGLSVGFVL 82
+ P A P + GP + + L L +F R+L + PVYLAG +GLS+ ++L
Sbjct: 4 EEPCAPGAPSALGAQRTPGPELRLSSQLLPELCTFVVRVLFYLGPVYLAGYLGLSITWLL 63
Query: 83 FGLALYLGWRRVRDEKERSLRAARQLLDDEEQLTAKTLYMSHRELPAWVSFPDVEKAEWL 142
G L++ WRR R K L AA + LD+E + ++ L H LPAW+ FPDVE+ EW
Sbjct: 64 LGALLWMWWRRNRRGKLGRLAAAFEFLDNEREFISRELRGQH--LPAWIHFPDVERVEWA 121
Query: 143 NKIVAQVWPFLGQYMEKLLAETVAPAVRGSNPHLQTFTFTRVELGEKPLRIIGVKVHPGQ 202
NKI++Q WP+L ME E + P +R + HL+TFTFT++ G+K R+ GVK H
Sbjct: 122 NKIISQTWPYLSMIMESKFREKLEPKIREKSIHLRTFTFTKLYFGQKCPRVNGVKAHTNT 181
Query: 203 -RKEQILLDLNISYVGDVQIDVEVKKYFCKAGVKGMQLHGVLRVILEPLIGDLPFVGAVS 261
+ ++ +DL I Y+GD +I VE++K +AGV G+QL G LRVILEPL+ D PFVGAV+
Sbjct: 182 CNRRRVTVDLQICYIGDCEISVELQKI--QAGVNGIQLQGTLRVILEPLLVDKPFVGAVT 239
Query: 262 MFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQ 321
+FF+++P L INWTG+TNLLD PG++ +SD+++ D IA LVLPNR+ VP+ L D+
Sbjct: 240 VFFLQKPHLQINWTGLTNLLDAPGINDVSDSLLEDLIATHLVLPNRVTVPVKKGL-DLTN 298
Query: 322 LRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQ 381
LR PLP G+IR+HLL A L+ KD ++ + GKSDPYA V +G Q F SR I LNP
Sbjct: 299 LRFPLPCGVIRVHLLEAEQLAQKDNFLG--LRGKSDPYAKVSIGLQHFRSRTIYRNLNPT 356
Query: 382 WGETYEVMVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDVGKVLQASVLDDWFPLQG-GQG 440
W E +E MV+EVPGQ++EV+++D+D D+DDFLG +++ +G V+ V+D+WF L G
Sbjct: 357 WNEVFEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSG 416
Query: 441 QVHLRLEWLSLLSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQDLP--------- 491
++HLRLEWLSLL+D E L + + G+S+ AILVV+L+ A +LP
Sbjct: 417 RLHLRLEWLSLLTDQEVLTED---HGGLST-------AILVVFLESACNLPRNPFDYLNG 466
Query: 492 -----------LKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQE 540
K +K+P+ V+LS+ T SK PVW + F FF+ + ++
Sbjct: 467 EYRAKKLSRFARNKVSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATER 526
Query: 541 LDVQVKDDSRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMRILYLDS 600
L ++V DD + LG L +PL ++L +L L+Q FQL SG +S + M+LV+R L ++
Sbjct: 527 LHLKVLDDDQECALGMLEVPLCQILPYADLTLEQRFQLDHSGLDSLISMRLVLRFLQVEE 586
Query: 601 SEICFP 606
E+ P
Sbjct: 587 RELGSP 592
Score = 176 bits (446), Expect = 1e-43
Identities = 103/271 (38%), Positives = 149/271 (54%), Gaps = 34/271 (12%)
Query: 648 VLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVI 707
V+R+H+LEA+ L KD FLG ++GKSDPY K+ + + FRS + +LNP WNEVFE +
Sbjct: 307 VIRVHLLEAEQLAQKDNFLG--LRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFM 364
Query: 708 VTSVPGQELEVEVFDKDLDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLER 767
V VPGQ+LEV+++D+D D+DDFLG ++ L V+ + +DEW L D SGRLHLRLE
Sbjct: 365 VYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSGRLHLRLEW 424
Query: 768 LTPRPTAAELEEVLQVNSLIQTQKSAELAAALLSIYMERAEDLP---------------- 811
L+ L + + T+ L+ A+L +++E A +LP
Sbjct: 425 LS-----------LLTDQEVLTEDHGGLSTAILVVFLESACNLPRNPFDYLNGEYRAKKL 473
Query: 812 ----LRKGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQVRG 867
K +K S Y L+VG +H +KT PVW + SF + TE L L+V
Sbjct: 474 SRFARNKVSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLD 533
Query: 868 EGTG-VLGSLSLPLSELLVADQLCLDRWFTL 897
+ LG L +PL ++L L L++ F L
Sbjct: 534 DDQECALGMLEVPLCQILPYADLTLEQRFQL 564
Score = 107 bits (267), Expect = 6e-23
Identities = 51/127 (40%), Positives = 85/127 (66%)
Query: 972 LGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTKRRTSQKKR 1031
LG+++LT+ Y R L +++GCR+L DPYV + LLP++ +++TS K++
Sbjct: 755 LGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSGADPYVRVYLLPERKWACRKKTSVKRK 814
Query: 1032 TLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVAR 1091
TL P F+E FE+ +P++E ++R LDV+VK++ S R+ LGKV +DL++ DL +G ++
Sbjct: 815 TLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKEDLIKGFSQ 874
Query: 1092 WYDLMDN 1098
WY+L N
Sbjct: 875 WYELTPN 881
>gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Homo
sapiens]
Length = 823
Score = 102 bits (254), Expect = 2e-21
Identities = 118/443 (26%), Positives = 191/443 (43%), Gaps = 71/443 (16%)
Query: 330 IIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQT-FCSRVIDEELNPQWGETYEV 388
++ IHL R L +D+ G SDPY +L +T + S+VI + LNP W E +
Sbjct: 195 LLTIHLKEGRNLVVRDRC------GTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVL 248
Query: 389 MVHEVPGQEIEVEVFDKDPDKDDFLGRM-----KLDVGKVLQASV-LDDWFPLQGGQGQV 442
+ + Q++ V+V+D+D DF+G L++ + + + L+D L+ G +
Sbjct: 249 PIQSLD-QKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGVI 307
Query: 443 HLRLEWLSLLSD-------------AEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQD 489
L L + D A K + S + + I+ + L ++
Sbjct: 308 VLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKN 367
Query: 490 LPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQV--KD 547
+ G VQL + D +SK + + P W+E F F + LD++V KD
Sbjct: 368 V---SGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKD 424
Query: 548 DSR--------ALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMRILYLD 599
+ + + + AL L A L EL LD + L + + +
Sbjct: 425 NKKHEERLGTCKVDISALPLKQANCL---ELPLDSCL-------GALLMLVTLTPCAGVS 474
Query: 600 SSEICFPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHVLRIHVLEAQDL 659
S++C CP A D+ SE Q R C +L++ VL+A DL
Sbjct: 475 VSDLCV-----CPLA-DL-SERKQ------ITQRYCLQNSLKDVKDVGILQVKVLKAADL 521
Query: 660 IAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIVTSVPGQELEVE 719
+A D GKSDP+ L+L ++H V ++LNP WN+VF + + LEV
Sbjct: 522 LAAD------FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDI-HDVLEVT 574
Query: 720 VFDKDLDK-DDFLGRCKVRLTTV 741
VFD+D DK DFLG+ + L ++
Sbjct: 575 VFDEDGDKPPDFLGKVAIPLLSI 597
Score = 89.4 bits (220), Expect = 2e-17
Identities = 76/286 (26%), Positives = 139/286 (48%), Gaps = 34/286 (11%)
Query: 647 HVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRS-FRSHVVREDLNPRWNEVFE 705
++L IH+ E ++L+ +DR G SDPYVK KL G++ ++S V+ ++LNP W+E+
Sbjct: 194 YLLTIHLKEGRNLVVRDRC------GTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVV 247
Query: 706 VIVTSVPGQELEVEVFDKDLDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPS-----GR 760
+ + S+ Q+L V+V+D+DL DF+G V L+ + + + L LED S G
Sbjct: 248 LPIQSLD-QKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGV 306
Query: 761 LHLRLERLTP------------RPTAAELEEVLQVNSLIQTQKSAELAAALLSIYMERAE 808
+ L L + + +A +++ L ++ K +L ++SI + +
Sbjct: 307 IVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGK 366
Query: 809 DLPLRKGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQVRGE 868
++ G + L +GD +K+KT+ +++ P W E F L+++V G+
Sbjct: 367 NV---SGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGK 423
Query: 869 GTGV----LGSLSLPLSELLVADQLCLDRWFTLSSGQGQVLLRAQL 910
LG+ + +S L + CL+ L S G +L+ L
Sbjct: 424 DNKKHEERLGTCKVDISALPLKQANCLE--LPLDSCLGALLMLVTL 467
Score = 55.5 bits (132), Expect = 3e-07
Identities = 30/91 (32%), Positives = 51/91 (56%), Gaps = 8/91 (8%)
Query: 329 GIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQWGETYEV 388
GI+++ +L A L + D GKSDP+ L+ LG + + + LNP+W + +
Sbjct: 509 GILQVKVLKAADLLAAD------FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTF 562
Query: 389 MVHEVPGQEIEVEVFDKDPDK-DDFLGRMKL 418
+ ++ +EV VFD+D DK DFLG++ +
Sbjct: 563 PIKDI-HDVLEVTVFDEDGDKPPDFLGKVAI 592
Score = 55.1 bits (131), Expect = 4e-07
Identities = 62/257 (24%), Positives = 111/257 (43%), Gaps = 30/257 (11%)
Query: 323 RSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQW 382
++ L GII I LL + +S ++ + ++LG Q + S+ + + NPQW
Sbjct: 350 KNQLWNGIISITLLEGKNVSGGSM---------TEMFVQLKLGDQRYKSKTLCKSANPQW 400
Query: 383 GETYEVMVHEVPGQEIEVEVFDKDPDK-DDFLGRMKLDVGKV--LQASVLDDWFPLQGGQ 439
E ++ +++EV+ KD K ++ LG K+D+ + QA+ L+ PL
Sbjct: 401 QEQFDFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLE--LPLDSCL 458
Query: 440 GQVHLRLEWLSL------------LSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRA 487
G + + + L+D + +Q+ Q +S D IL V + +A
Sbjct: 459 GALLMLVTLTPCAGVSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKA 518
Query: 488 QDLPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKD 547
DL + + +P L + + ++ VY P W + F F ++D L+V V D
Sbjct: 519 ADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIH-DVLEVTVFD 577
Query: 548 ---DSRALTLGALTLPL 561
D LG + +PL
Sbjct: 578 EDGDKPPDFLGKVAIPL 594
>gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Homo
sapiens]
Length = 878
Score = 102 bits (254), Expect = 2e-21
Identities = 118/443 (26%), Positives = 191/443 (43%), Gaps = 71/443 (16%)
Query: 330 IIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQT-FCSRVIDEELNPQWGETYEV 388
++ IHL R L +D+ G SDPY +L +T + S+VI + LNP W E +
Sbjct: 195 LLTIHLKEGRNLVVRDRC------GTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVL 248
Query: 389 MVHEVPGQEIEVEVFDKDPDKDDFLGRM-----KLDVGKVLQASV-LDDWFPLQGGQGQV 442
+ + Q++ V+V+D+D DF+G L++ + + + L+D L+ G +
Sbjct: 249 PIQSLD-QKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGVI 307
Query: 443 HLRLEWLSLLSD-------------AEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQD 489
L L + D A K + S + + I+ + L ++
Sbjct: 308 VLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKN 367
Query: 490 LPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQV--KD 547
+ G VQL + D +SK + + P W+E F F + LD++V KD
Sbjct: 368 V---SGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKD 424
Query: 548 DSR--------ALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMRILYLD 599
+ + + + AL L A L EL LD + L + + +
Sbjct: 425 NKKHEERLGTCKVDISALPLKQANCL---ELPLDSCL-------GALLMLVTLTPCAGVS 474
Query: 600 SSEICFPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHVLRIHVLEAQDL 659
S++C CP A D+ SE Q R C +L++ VL+A DL
Sbjct: 475 VSDLCV-----CPLA-DL-SERKQ------ITQRYCLQNSLKDVKDVGILQVKVLKAADL 521
Query: 660 IAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIVTSVPGQELEVE 719
+A D GKSDP+ L+L ++H V ++LNP WN+VF + + LEV
Sbjct: 522 LAAD------FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDI-HDVLEVT 574
Query: 720 VFDKDLDK-DDFLGRCKVRLTTV 741
VFD+D DK DFLG+ + L ++
Sbjct: 575 VFDEDGDKPPDFLGKVAIPLLSI 597
Score = 89.4 bits (220), Expect = 2e-17
Identities = 76/286 (26%), Positives = 139/286 (48%), Gaps = 34/286 (11%)
Query: 647 HVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRS-FRSHVVREDLNPRWNEVFE 705
++L IH+ E ++L+ +DR G SDPYVK KL G++ ++S V+ ++LNP W+E+
Sbjct: 194 YLLTIHLKEGRNLVVRDRC------GTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVV 247
Query: 706 VIVTSVPGQELEVEVFDKDLDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPS-----GR 760
+ + S+ Q+L V+V+D+DL DF+G V L+ + + + L LED S G
Sbjct: 248 LPIQSLD-QKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGV 306
Query: 761 LHLRLERLTP------------RPTAAELEEVLQVNSLIQTQKSAELAAALLSIYMERAE 808
+ L L + + +A +++ L ++ K +L ++SI + +
Sbjct: 307 IVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGK 366
Query: 809 DLPLRKGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQVRGE 868
++ G + L +GD +K+KT+ +++ P W E F L+++V G+
Sbjct: 367 NV---SGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGK 423
Query: 869 GTGV----LGSLSLPLSELLVADQLCLDRWFTLSSGQGQVLLRAQL 910
LG+ + +S L + CL+ L S G +L+ L
Sbjct: 424 DNKKHEERLGTCKVDISALPLKQANCLE--LPLDSCLGALLMLVTL 467
Score = 55.5 bits (132), Expect = 3e-07
Identities = 30/91 (32%), Positives = 51/91 (56%), Gaps = 8/91 (8%)
Query: 329 GIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQWGETYEV 388
GI+++ +L A L + D GKSDP+ L+ LG + + + LNP+W + +
Sbjct: 509 GILQVKVLKAADLLAAD------FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTF 562
Query: 389 MVHEVPGQEIEVEVFDKDPDK-DDFLGRMKL 418
+ ++ +EV VFD+D DK DFLG++ +
Sbjct: 563 PIKDI-HDVLEVTVFDEDGDKPPDFLGKVAI 592
Score = 55.1 bits (131), Expect = 4e-07
Identities = 62/257 (24%), Positives = 111/257 (43%), Gaps = 30/257 (11%)
Query: 323 RSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQW 382
++ L GII I LL + +S ++ + ++LG Q + S+ + + NPQW
Sbjct: 350 KNQLWNGIISITLLEGKNVSGGSM---------TEMFVQLKLGDQRYKSKTLCKSANPQW 400
Query: 383 GETYEVMVHEVPGQEIEVEVFDKDPDK-DDFLGRMKLDVGKV--LQASVLDDWFPLQGGQ 439
E ++ +++EV+ KD K ++ LG K+D+ + QA+ L+ PL
Sbjct: 401 QEQFDFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLE--LPLDSCL 458
Query: 440 GQVHLRLEWLSL------------LSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRA 487
G + + + L+D + +Q+ Q +S D IL V + +A
Sbjct: 459 GALLMLVTLTPCAGVSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKA 518
Query: 488 QDLPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKD 547
DL + + +P L + + ++ VY P W + F F ++D L+V V D
Sbjct: 519 ADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIH-DVLEVTVFD 577
Query: 548 ---DSRALTLGALTLPL 561
D LG + +PL
Sbjct: 578 EDGDKPPDFLGKVAIPL 594
>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
sapiens]
Length = 778
Score = 89.7 bits (221), Expect = 1e-17
Identities = 71/255 (27%), Positives = 121/255 (47%), Gaps = 23/255 (9%)
Query: 323 RSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQW 382
+S L RGI+ I L+ R L + D G SDPY RLG Q + S+++ + LNPQW
Sbjct: 243 KSHLWRGIVSITLIEGRDLKAMDS------NGLSDPYVKFRLGHQKYKSKIMPKTLNPQW 296
Query: 383 GETYEVMVHEVPGQEIEVEVFDKDPDK-DDFLGRMKLDVGKVLQASVLDDWFPLQGGQGQ 441
E ++ ++E G I++ +DKD K DDF+GR ++D+ + + L+ G+G
Sbjct: 297 REQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGH 356
Query: 442 VHLRLEW------------LSLLSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQD 489
+ L + ++ L D ++ E++L+ + + L V + RA+
Sbjct: 357 LVLLVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEG 416
Query: 490 LPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKDDS 549
L + +P + + + + VY P W + F F ++D S L+V V D+
Sbjct: 417 LMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHS-VLEVTVYDED 475
Query: 550 R---ALTLGALTLPL 561
R A LG + +PL
Sbjct: 476 RDRSADFLGKVAIPL 490
Score = 84.7 bits (208), Expect = 4e-16
Identities = 72/260 (27%), Positives = 120/260 (46%), Gaps = 30/260 (11%)
Query: 648 VLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVI 707
++ I ++E +DL A D G SDPYVK +L + ++S ++ + LNP+W E F+
Sbjct: 250 IVSITLIEGRDLKAMDS------NGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFH 303
Query: 708 VTSVPGQELEVEVFDKDLDK-DDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLE 766
+ G +++ +DKD K DDF+GRC+V L+ + L LE+ G HL L
Sbjct: 304 LYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEE---GEGHLVL- 359
Query: 767 RLTPRPTAAELEEVLQVNSLIQTQKSAELA--------------AALLSIYMERAEDLPL 812
+T +A L VNSL ++ E+ L + + RAE L
Sbjct: 360 LVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMA 419
Query: 813 RKGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQV----RGE 868
T P+ + + + T T+ + P W++ +F I+ H+ LE+ V R
Sbjct: 420 ADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHS-VLEVTVYDEDRDR 478
Query: 869 GTGVLGSLSLPLSELLVADQ 888
LG +++PL + +Q
Sbjct: 479 SADFLGKVAIPLLSIQNGEQ 498
Score = 61.2 bits (147), Expect = 5e-09
Identities = 50/152 (32%), Positives = 76/152 (50%), Gaps = 11/152 (7%)
Query: 649 LRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRS-FRSHVVREDLNPRWNEVFEVI 707
L I + Q L A+DR G SDPYVK K+ G+ FRS ++ ++LNP W E ++
Sbjct: 42 LDITLRRGQSLAARDR------GGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACIL 95
Query: 708 VTSVPGQELEVEVFDKDLD-KDDFLGRCKVRLTTVLNSGFLDEWLTLED--VPSGRLHLR 764
V + + L ++VFD D +DDF+G + LT + + D LTL+D P L +
Sbjct: 96 VDHL-REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPHYPDHDLGII 154
Query: 765 LERLTPRPTAAELEEVLQVNSLIQTQKSAELA 796
L + P E +V + + S EL+
Sbjct: 155 LLSVILTPKEGESRDVTMLMRKSWKRSSKELS 186
Score = 43.5 bits (101), Expect = 0.001
Identities = 30/96 (31%), Positives = 54/96 (56%), Gaps = 11/96 (11%)
Query: 329 GIIRIHLLAARG--LSSKDKYVKGLIEGKSDPYALVRLG-TQTFCSRVIDEELNPQWGET 385
G+ ++ + RG L+++D+ G SDPY ++G + F S++I + LNP W E
Sbjct: 38 GMYQLDITLRRGQSLAARDR------GGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEK 91
Query: 386 YEVMVHEVPGQEIEVEVFDKDPD-KDDFLGRMKLDV 420
++V + + + ++VFD D +DDF+G LD+
Sbjct: 92 ACILVDHL-REPLYIKVFDYDFGLQDDFMGSAFLDL 126
Score = 32.7 bits (73), Expect = 1.9
Identities = 33/148 (22%), Positives = 56/148 (37%), Gaps = 14/148 (9%)
Query: 775 AELEEVLQVNSLIQTQ--------KSAELAAALLSIYMERAEDLPLRKGTKHLSPYATLT 826
AEL+ N QTQ + + L ++SI + DL PY
Sbjct: 218 AELQNPYCKNVQFQTQSLRLSDLHRKSHLWRGIVSITLIEGRDLKAMDSNGLSDPYVKFR 277
Query: 827 VGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQV----RGEGTGVLGSLSLPLSE 882
+G +K+K + +T P W E F + + +++ G+ +G + LS
Sbjct: 278 LGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSA 337
Query: 883 LLVADQLCLDRWFTLSSGQGQVLLRAQL 910
L L+ L G+G ++L L
Sbjct: 338 LSREQTHKLE--LQLEEGEGHLVLLVTL 363
>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
sapiens]
Length = 999
Score = 89.7 bits (221), Expect = 1e-17
Identities = 71/255 (27%), Positives = 121/255 (47%), Gaps = 23/255 (9%)
Query: 323 RSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQW 382
+S L RGI+ I L+ R L + D G SDPY RLG Q + S+++ + LNPQW
Sbjct: 464 KSHLWRGIVSITLIEGRDLKAMDS------NGLSDPYVKFRLGHQKYKSKIMPKTLNPQW 517
Query: 383 GETYEVMVHEVPGQEIEVEVFDKDPDK-DDFLGRMKLDVGKVLQASVLDDWFPLQGGQGQ 441
E ++ ++E G I++ +DKD K DDF+GR ++D+ + + L+ G+G
Sbjct: 518 REQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGH 577
Query: 442 VHLRLEW------------LSLLSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQD 489
+ L + ++ L D ++ E++L+ + + L V + RA+
Sbjct: 578 LVLLVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEG 637
Query: 490 LPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKDDS 549
L + +P + + + + VY P W + F F ++D S L+V V D+
Sbjct: 638 LMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHS-VLEVTVYDED 696
Query: 550 R---ALTLGALTLPL 561
R A LG + +PL
Sbjct: 697 RDRSADFLGKVAIPL 711
Score = 84.7 bits (208), Expect = 4e-16
Identities = 72/260 (27%), Positives = 120/260 (46%), Gaps = 30/260 (11%)
Query: 648 VLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVI 707
++ I ++E +DL A D G SDPYVK +L + ++S ++ + LNP+W E F+
Sbjct: 471 IVSITLIEGRDLKAMDS------NGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFH 524
Query: 708 VTSVPGQELEVEVFDKDLDK-DDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLE 766
+ G +++ +DKD K DDF+GRC+V L+ + L LE+ G HL L
Sbjct: 525 LYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEE---GEGHLVL- 580
Query: 767 RLTPRPTAAELEEVLQVNSLIQTQKSAELA--------------AALLSIYMERAEDLPL 812
+T +A L VNSL ++ E+ L + + RAE L
Sbjct: 581 LVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMA 640
Query: 813 RKGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQV----RGE 868
T P+ + + + T T+ + P W++ +F I+ H+ LE+ V R
Sbjct: 641 ADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHS-VLEVTVYDEDRDR 699
Query: 869 GTGVLGSLSLPLSELLVADQ 888
LG +++PL + +Q
Sbjct: 700 SADFLGKVAIPLLSIQNGEQ 719
Score = 63.2 bits (152), Expect = 1e-09
Identities = 58/201 (28%), Positives = 90/201 (44%), Gaps = 17/201 (8%)
Query: 606 PTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTE------HVLRIHVLEAQDL 659
P P P +S P+ G + + +T S + L I + Q L
Sbjct: 214 PPPPAEPARSPAESRAPETGEEHGSSQKIINTAGTSNAEVPLADPGMYQLDITLRRGQSL 273
Query: 660 IAKDRFLGGLVKGKSDPYVKLKLAGRS-FRSHVVREDLNPRWNEVFEVIVTSVPGQELEV 718
A+DR G SDPYVK K+ G+ FRS ++ ++LNP W E ++V + + L +
Sbjct: 274 AARDR------GGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHL-REPLYI 326
Query: 719 EVFDKDLD-KDDFLGRCKVRLTTVLNSGFLDEWLTLED--VPSGRLHLRLERLTPRPTAA 775
+VFD D +DDF+G + LT + + D LTL+D P L + L + P
Sbjct: 327 KVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPHYPDHDLGIILLSVILTPKEG 386
Query: 776 ELEEVLQVNSLIQTQKSAELA 796
E +V + + S EL+
Sbjct: 387 ESRDVTMLMRKSWKRSSKELS 407
Score = 43.5 bits (101), Expect = 0.001
Identities = 30/96 (31%), Positives = 54/96 (56%), Gaps = 11/96 (11%)
Query: 329 GIIRIHLLAARG--LSSKDKYVKGLIEGKSDPYALVRLG-TQTFCSRVIDEELNPQWGET 385
G+ ++ + RG L+++D+ G SDPY ++G + F S++I + LNP W E
Sbjct: 259 GMYQLDITLRRGQSLAARDR------GGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEK 312
Query: 386 YEVMVHEVPGQEIEVEVFDKDPD-KDDFLGRMKLDV 420
++V + + + ++VFD D +DDF+G LD+
Sbjct: 313 ACILVDHL-REPLYIKVFDYDFGLQDDFMGSAFLDL 347
Score = 32.7 bits (73), Expect = 1.9
Identities = 33/148 (22%), Positives = 56/148 (37%), Gaps = 14/148 (9%)
Query: 775 AELEEVLQVNSLIQTQ--------KSAELAAALLSIYMERAEDLPLRKGTKHLSPYATLT 826
AEL+ N QTQ + + L ++SI + DL PY
Sbjct: 439 AELQNPYCKNVQFQTQSLRLSDLHRKSHLWRGIVSITLIEGRDLKAMDSNGLSDPYVKFR 498
Query: 827 VGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQV----RGEGTGVLGSLSLPLSE 882
+G +K+K + +T P W E F + + +++ G+ +G + LS
Sbjct: 499 LGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSA 558
Query: 883 LLVADQLCLDRWFTLSSGQGQVLLRAQL 910
L L+ L G+G ++L L
Sbjct: 559 LSREQTHKLE--LQLEEGEGHLVLLVTL 584
>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
[Homo sapiens]
Length = 1634
Score = 80.5 bits (197), Expect = 8e-15
Identities = 53/138 (38%), Positives = 79/138 (57%), Gaps = 9/138 (6%)
Query: 962 DSPLEAPAGPLG-QVKLTLWYYSEERKLVSIVHGCRSLR--QNGRDPPDPYVSLLLLPDK 1018
D P G +G +VKL++ Y + KL +V R L+ Q+G DP DPYV + LLPD
Sbjct: 1494 DGTWARPVGKVGGEVKLSISY--KNNKLFIMVMHIRGLQLLQDGNDP-DPYVKIYLLPDP 1550
Query: 1019 NRGTKRRTSQKKRTLSPEFNERFEWE-LPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQ 1077
+ TKR+T ++T +P +NE ++ +P + Q+R+L +SV S F E LLG+V
Sbjct: 1551 QKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFW--ENVLLGEVN 1608
Query: 1078 LDLAETDLSQGVARWYDL 1095
+ L E DL+Q W+ L
Sbjct: 1609 IRLRELDLAQEKTGWFAL 1626
>gi|154354981 regulating synaptic membrane exocytosis 2 isoform b
[Homo sapiens]
Length = 1163
Score = 74.3 bits (181), Expect = 6e-13
Identities = 57/194 (29%), Positives = 98/194 (50%), Gaps = 17/194 (8%)
Query: 909 QLGILVSQHSG----VEAHSHSYSHSSSSLSEEPELSGGPPHITSSAPELRQRLTHVDSP 964
Q+ ++VS+ G + +H+ SSSS E ++ P I+ ++P L V
Sbjct: 477 QVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDR--PSISVTSPMSPGMLRDVPQF 534
Query: 965 LEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSL--RQNGRDPPDPYVSLLLLPDKNRGT 1022
L GQ+ + LW+ +L+ + G + L R++GR P +PYV + LPD++
Sbjct: 535 LS------GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGR-PRNPYVKIYFLPDRSDKN 587
Query: 1023 KRRTSQKKRTLSPEFNERFEWE-LPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLA 1081
KRRT K+TL P++N+ F + + E + R L++++ + E E LG++ ++L
Sbjct: 588 KRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIEL- 646
Query: 1082 ETDLSQGVARWYDL 1095
ET L WY L
Sbjct: 647 ETALLDDEPHWYKL 660
Score = 36.6 bits (83), Expect = 0.13
Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 4/90 (4%)
Query: 1006 PDPYVSLLLLPDKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSF 1065
P PYV + LL + K++T ++TL P + + +E + Q + L + V +
Sbjct: 1044 PAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFE---ESPQGKVLQIIVWGDYGR 1100
Query: 1066 MSRERELLGKVQLDLAETDLSQGVARWYDL 1095
M + +G Q+ L E +LS V W+ L
Sbjct: 1101 MD-HKSFMGVAQILLDELELSNMVIGWFKL 1129
Score = 33.9 bits (76), Expect = 0.87
Identities = 58/256 (22%), Positives = 105/256 (41%), Gaps = 57/256 (22%)
Query: 647 HVLRIHVLEAQDLIAKDRFLGGLVKGKS-DPYVKLK-LAGRSF----RSHVVREDLNPRW 700
H L + +L A+DL +++ G+ +PYVK+ L RS R+ V++ L P+W
Sbjct: 550 HQLIVTILGAKDLPSRE-------DGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKW 602
Query: 701 NEVFEVIVTSVPGQE-----LEVEVFDKDL---DKDDFLGRCKVRLTTVLNSGFLDE--- 749
N+ F I + V +E LE+ ++D+ ++ +FLG + L T L LD+
Sbjct: 603 NQTF--IYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETAL----LDDEPH 656
Query: 750 WLTLE-------DVPSGRLHLRLERLTPRPTAAELEEVLQVNSLIQTQKSAELAAALLSI 802
W L+ +P ++ +L L+ +++ + + ++S
Sbjct: 657 WYKLQTHDVSSLPLPHPSPYMPRRQLHGESPTRRLQRSKRISDSEVSDYDCDDGIGVVSD 716
Query: 803 YMERAEDLPLR--------KGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIR 854
Y DL + H SP S H+ I +T + W S +
Sbjct: 717 YRHDGRDLQSSTLSVPEQVMSSNHCSP------SGSPHRVDVIGRTRS--WSPS----VP 764
Query: 855 KPHTESLELQVRGEGT 870
P + ++E +RG T
Sbjct: 765 PPQSRNVEQGLRGTRT 780
>gi|154354983 regulating synaptic membrane exocytosis 2 isoform a
[Homo sapiens]
Length = 1349
Score = 70.1 bits (170), Expect = 1e-11
Identities = 49/184 (26%), Positives = 86/184 (46%), Gaps = 5/184 (2%)
Query: 915 SQHSGVEAHSHSYSHSSSSLSEEPELSGGPPHITSSAPELRQRLTHVDSPLEAPAGPLGQ 974
S H+ +E+ S S+ S P + P+ S + +
Sbjct: 687 STHAQLESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSSQSLSRRTTPFVPR 746
Query: 975 VKLTLWYYSEERKLVSIVHGCRSL--RQNGRDPPDPYVSLLLLPDKNRGTKRRTSQKKRT 1032
V++ LW+ +L+ + G + L R++GR P +PYV + LPD++ KRRT K+T
Sbjct: 747 VQIKLWFDKVGHQLIVTILGAKDLPSREDGR-PRNPYVKIYFLPDRSDKNKRRTKTVKKT 805
Query: 1033 LSPEFNERFEWE-LPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVAR 1091
L P++N+ F + + E + R L++++ + E E LG++ ++L ET L
Sbjct: 806 LEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIEL-ETALLDDEPH 864
Query: 1092 WYDL 1095
WY L
Sbjct: 865 WYKL 868
Score = 36.6 bits (83), Expect = 0.13
Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 4/90 (4%)
Query: 1006 PDPYVSLLLLPDKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSF 1065
P PYV + LL + K++T ++TL P + + +E + Q + L + V +
Sbjct: 1230 PAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFE---ESPQGKVLQIIVWGDYGR 1286
Query: 1066 MSRERELLGKVQLDLAETDLSQGVARWYDL 1095
M + +G Q+ L E +LS V W+ L
Sbjct: 1287 MD-HKSFMGVAQILLDELELSNMVIGWFKL 1315
Score = 33.9 bits (76), Expect = 0.87
Identities = 58/256 (22%), Positives = 105/256 (41%), Gaps = 57/256 (22%)
Query: 647 HVLRIHVLEAQDLIAKDRFLGGLVKGKS-DPYVKLK-LAGRSF----RSHVVREDLNPRW 700
H L + +L A+DL +++ G+ +PYVK+ L RS R+ V++ L P+W
Sbjct: 758 HQLIVTILGAKDLPSRE-------DGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKW 810
Query: 701 NEVFEVIVTSVPGQE-----LEVEVFDKDL---DKDDFLGRCKVRLTTVLNSGFLDE--- 749
N+ F I + V +E LE+ ++D+ ++ +FLG + L T L LD+
Sbjct: 811 NQTF--IYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETAL----LDDEPH 864
Query: 750 WLTLE-------DVPSGRLHLRLERLTPRPTAAELEEVLQVNSLIQTQKSAELAAALLSI 802
W L+ +P ++ +L L+ +++ + + ++S
Sbjct: 865 WYKLQTHDVSSLPLPHPSPYMPRRQLHGESPTRRLQRSKRISDSEVSDYDCDDGIGVVSD 924
Query: 803 YMERAEDLPLR--------KGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIR 854
Y DL + H SP S H+ I +T + W S +
Sbjct: 925 YRHDGRDLQSSTLSVPEQVMSSNHCSP------SGSPHRVDVIGRTRS--WSPS----VP 972
Query: 855 KPHTESLELQVRGEGT 870
P + ++E +RG T
Sbjct: 973 PPQSRNVEQGLRGTRT 988
>gi|41054864 regulating synaptic membrane exocytosis 1 [Homo sapiens]
Length = 1692
Score = 69.3 bits (168), Expect = 2e-11
Identities = 60/199 (30%), Positives = 96/199 (48%), Gaps = 17/199 (8%)
Query: 909 QLGILVSQHSG----VEAHSHSYSHSSSSLSEEPELSGGPPHITSSAPELRQRLTHVDSP 964
Q+ I+VS+ G + SH SSSS E ++ P I+ +P L D+P
Sbjct: 684 QVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMER--PSISVISPTSPGALK--DAP 739
Query: 965 LEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSL--RQNGRDPPDPYVSLLLLPDKNRGT 1022
P GQ+ + LWY +L+ V L R +GR P +PYV + LPD++ +
Sbjct: 740 QVLP----GQLSVKLWYDKVGHQLIVNVLQATDLPARVDGR-PRNPYVKMYFLPDRSDKS 794
Query: 1023 KRRTSQKKRTLSPEFNERFEW-ELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLA 1081
KRRT K+ L P++N+ F + + + + R L+++V E E LG++ ++L
Sbjct: 795 KRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIEL- 853
Query: 1082 ETDLSQGVARWYDLMDNKD 1100
ET L WY L + +
Sbjct: 854 ETALLDDEPHWYKLQTHDE 872
Score = 38.9 bits (89), Expect = 0.027
Identities = 31/102 (30%), Positives = 48/102 (47%), Gaps = 6/102 (5%)
Query: 996 RSLRQN--GRDPPDPYVSLLLLPDKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRR 1053
RSL Q + P PYV + LL + K++T ++TL P + + ++ + Q +
Sbjct: 1561 RSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFD---ESPQGK 1617
Query: 1054 KLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVARWYDL 1095
L V V + M + +G Q+ L E DLS V WY L
Sbjct: 1618 VLQVIVWGDYGRMD-HKCFMGVAQILLEELDLSSMVIGWYKL 1658
Score = 37.4 bits (85), Expect = 0.079
Identities = 35/108 (32%), Positives = 55/108 (50%), Gaps = 19/108 (17%)
Query: 647 HVLRIHVLEAQDLIAKDRFLGGLVKGKS-DPYVKLK-LAGRSFRSH----VVREDLNPRW 700
H L ++VL+A DL A+ V G+ +PYVK+ L RS +S V++ L P+W
Sbjct: 757 HQLIVNVLQATDLPAR-------VDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKW 809
Query: 701 NEVF---EVIVTSVPGQELEVEVFDK---DLDKDDFLGRCKVRLTTVL 742
N+ F V + LE+ V+D+ ++ +FLG + L T L
Sbjct: 810 NQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETAL 857
>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 757
Score = 68.2 bits (165), Expect = 4e-11
Identities = 73/290 (25%), Positives = 125/290 (43%), Gaps = 59/290 (20%)
Query: 480 LVVYLDRAQDLPLKK--GNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQ 537
L + + ++LP K G+ +P +V++ + + + + V+ T CP W E ++ L P
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTA-TVWKTLCPFWGEEYQVHLP-PT 64
Query: 538 SQELDVQVKDD---SRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMR 594
+ V D+ SR +G + L + + P+ W L+ P+ + ++ +R
Sbjct: 65 FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGF-SGWAHLTEVDPDEEVQGEIHLR 123
Query: 595 ILYLDSSEICFPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHVLRIHVL 654
+ E+ PGA R C LR VL
Sbjct: 124 L------EVW-------PGA------------------RACR------------LRCSVL 140
Query: 655 EAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIVTSVPGQ 714
EA+DL KDR G SDP+V+++ GR+ + +V++ PRWNE FE + +
Sbjct: 141 EARDLAPKDR------NGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAME 194
Query: 715 ELEVEVFDKDL-DKDDFLGRCKVRLTTVLNSGFLDEWLTLE-DVPSGRLH 762
L VE +D DL ++DFLG+ + + + + W L+ D R H
Sbjct: 195 ALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRH 244
Score = 63.5 bits (153), Expect = 1e-09
Identities = 71/273 (26%), Positives = 116/273 (42%), Gaps = 48/273 (17%)
Query: 328 RGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFC-SRVIDEELNPQWGETY 386
R + I ++ + L +KD I G SDPY +V++ + + + + L P WGE Y
Sbjct: 4 RSSLYIRIVEGKNLPAKD------ITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEY 57
Query: 387 EVMVHEVPG-QEIEVEVFDKDP-DKDDFLGRMKLDVGKVLQA-------SVLDDWFPLQG 437
+V H P + V D+D +DD +G++ L + + L + P +
Sbjct: 58 QV--HLPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEE 115
Query: 438 GQGQVHLRLE-WLSLLSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQDLPLKKGN 496
QG++HLRLE W P + + L+ A+DL K N
Sbjct: 116 VQGEIHLRLEVW-----------------------PGARACRLRCSVLE-ARDLAPKDRN 151
Query: 497 KEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKD---DSRALT 553
+P V++ + T+E+ V + P W E F F LQ+ + L V+ D SR
Sbjct: 152 GTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDF 211
Query: 554 LGALTLPLARLLTAPELILDQWFQLSSSGPNSR 586
LG + + + RL + + WF+L SR
Sbjct: 212 LGKVVIDVQRLRVVQQ--EEGWFRLQPDQSKSR 242
Score = 40.4 bits (93), Expect = 0.009
Identities = 43/145 (29%), Positives = 67/145 (46%), Gaps = 12/145 (8%)
Query: 958 LTHVDSPLEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRD-PPDPYVSLLLLP 1016
LT VD P E G + ++L +W + +L V R L R+ DP+V +
Sbjct: 107 LTEVD-PDEEVQGEI-HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRV---- 160
Query: 1017 DKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKV 1076
+ +G R TS K++ P +NE FE+E L E L V + +SR + LGKV
Sbjct: 161 -RYKGRTRETSIVKKSCYPRWNETFEFE--LQEGAMEALCVEA-WDWDLVSR-NDFLGKV 215
Query: 1077 QLDLAETDLSQGVARWYDLMDNKDK 1101
+D+ + Q W+ L ++ K
Sbjct: 216 VIDVQRLRVVQQEEGWFRLQPDQSK 240
>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 757
Score = 68.2 bits (165), Expect = 4e-11
Identities = 73/290 (25%), Positives = 125/290 (43%), Gaps = 59/290 (20%)
Query: 480 LVVYLDRAQDLPLKK--GNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQ 537
L + + ++LP K G+ +P +V++ + + + + V+ T CP W E ++ L P
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTA-TVWKTLCPFWGEEYQVHLP-PT 64
Query: 538 SQELDVQVKDD---SRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMR 594
+ V D+ SR +G + L + + P+ W L+ P+ + ++ +R
Sbjct: 65 FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGF-SGWAHLTEVDPDEEVQGEIHLR 123
Query: 595 ILYLDSSEICFPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHVLRIHVL 654
+ E+ PGA R C LR VL
Sbjct: 124 L------EVW-------PGA------------------RACR------------LRCSVL 140
Query: 655 EAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIVTSVPGQ 714
EA+DL KDR G SDP+V+++ GR+ + +V++ PRWNE FE + +
Sbjct: 141 EARDLAPKDR------NGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAME 194
Query: 715 ELEVEVFDKDL-DKDDFLGRCKVRLTTVLNSGFLDEWLTLE-DVPSGRLH 762
L VE +D DL ++DFLG+ + + + + W L+ D R H
Sbjct: 195 ALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRH 244
Score = 63.5 bits (153), Expect = 1e-09
Identities = 71/273 (26%), Positives = 116/273 (42%), Gaps = 48/273 (17%)
Query: 328 RGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFC-SRVIDEELNPQWGETY 386
R + I ++ + L +KD I G SDPY +V++ + + + + L P WGE Y
Sbjct: 4 RSSLYIRIVEGKNLPAKD------ITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEY 57
Query: 387 EVMVHEVPG-QEIEVEVFDKDP-DKDDFLGRMKLDVGKVLQA-------SVLDDWFPLQG 437
+V H P + V D+D +DD +G++ L + + L + P +
Sbjct: 58 QV--HLPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEE 115
Query: 438 GQGQVHLRLE-WLSLLSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQDLPLKKGN 496
QG++HLRLE W P + + L+ A+DL K N
Sbjct: 116 VQGEIHLRLEVW-----------------------PGARACRLRCSVLE-ARDLAPKDRN 151
Query: 497 KEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKD---DSRALT 553
+P V++ + T+E+ V + P W E F F LQ+ + L V+ D SR
Sbjct: 152 GTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDF 211
Query: 554 LGALTLPLARLLTAPELILDQWFQLSSSGPNSR 586
LG + + + RL + + WF+L SR
Sbjct: 212 LGKVVIDVQRLRVVQQ--EEGWFRLQPDQSKSR 242
Score = 40.4 bits (93), Expect = 0.009
Identities = 43/145 (29%), Positives = 67/145 (46%), Gaps = 12/145 (8%)
Query: 958 LTHVDSPLEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRD-PPDPYVSLLLLP 1016
LT VD P E G + ++L +W + +L V R L R+ DP+V +
Sbjct: 107 LTEVD-PDEEVQGEI-HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRV---- 160
Query: 1017 DKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKV 1076
+ +G R TS K++ P +NE FE+E L E L V + +SR + LGKV
Sbjct: 161 -RYKGRTRETSIVKKSCYPRWNETFEFE--LQEGAMEALCVEA-WDWDLVSR-NDFLGKV 215
Query: 1077 QLDLAETDLSQGVARWYDLMDNKDK 1101
+D+ + Q W+ L ++ K
Sbjct: 216 VIDVQRLRVVQQEEGWFRLQPDQSK 240
>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
Length = 694
Score = 68.2 bits (165), Expect = 4e-11
Identities = 38/130 (29%), Positives = 70/130 (53%), Gaps = 5/130 (3%)
Query: 973 GQVKLTLWYYSEERKLVSIVHGCRSLR-QNGRDPPDPYVSLLLLPDKNRGTKRRTSQKKR 1031
G++ ++L Y +++ L+ + C L + DP+V L L PD + K +T KK+
Sbjct: 552 GKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKK 611
Query: 1032 TLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVAR 1091
TL+PEFNE F +++ + ++ LD+SV + + + +G QL ++ + +
Sbjct: 612 TLNPEFNEEFFYDIKHSDLAKKSLDISVWDYD--IGKSNDYIGGCQLGISAK--GERLKH 667
Query: 1092 WYDLMDNKDK 1101
WY+ + NKDK
Sbjct: 668 WYECLKNKDK 677
Score = 47.4 bits (111), Expect = 8e-05
Identities = 46/178 (25%), Positives = 71/178 (39%), Gaps = 9/178 (5%)
Query: 914 VSQHSGVEAHSHSYSHSSSSLSEEPELSGGPPHITSSAP--ELRQRLTHVDSPLEAPAGP 971
V + V A SH S S+ + P P E + DS A
Sbjct: 336 VGGYPAVGAREDRMSHPSGPYSQASAAAPQPAAARQPPPPEEEEEEANSYDSD---EATT 392
Query: 972 LGQVKLTLWYYSEERKLVSIVHGCRSLR-QNGRDPPDPYVSLLLLPDKNRGTKRRTSQKK 1030
LG ++ +L Y + L + + L+ + DPYV L LLP ++ K RT +
Sbjct: 393 LGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLR 452
Query: 1031 RTLSPEFNERFEWELPLDE-AQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQ 1087
T +P +NE + DE QR+ L +SV F E +G+ + L + +Q
Sbjct: 453 NTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKF--GHNEFIGETRFSLKKLKPNQ 508
Score = 32.3 bits (72), Expect = 2.5
Identities = 22/76 (28%), Positives = 34/76 (44%), Gaps = 9/76 (11%)
Query: 672 GKSDPYVKLKL-----AGRSFRSHVVREDLNPRWNEVF---EVIVTSVPGQELEVEVFDK 723
G +DPYVKL L R+ +R NP WNE + + + L + V D+
Sbjct: 426 GLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDE 485
Query: 724 D-LDKDDFLGRCKVRL 738
D ++F+G + L
Sbjct: 486 DKFGHNEFIGETRFSL 501
>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
Length = 690
Score = 68.2 bits (165), Expect = 4e-11
Identities = 38/130 (29%), Positives = 70/130 (53%), Gaps = 5/130 (3%)
Query: 973 GQVKLTLWYYSEERKLVSIVHGCRSLR-QNGRDPPDPYVSLLLLPDKNRGTKRRTSQKKR 1031
G++ ++L Y +++ L+ + C L + DP+V L L PD + K +T KK+
Sbjct: 548 GKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKK 607
Query: 1032 TLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVAR 1091
TL+PEFNE F +++ + ++ LD+SV + + + +G QL ++ + +
Sbjct: 608 TLNPEFNEEFFYDIKHSDLAKKSLDISVWDYD--IGKSNDYIGGCQLGISAK--GERLKH 663
Query: 1092 WYDLMDNKDK 1101
WY+ + NKDK
Sbjct: 664 WYECLKNKDK 673
Score = 47.4 bits (111), Expect = 8e-05
Identities = 46/178 (25%), Positives = 71/178 (39%), Gaps = 9/178 (5%)
Query: 914 VSQHSGVEAHSHSYSHSSSSLSEEPELSGGPPHITSSAP--ELRQRLTHVDSPLEAPAGP 971
V + V A SH S S+ + P P E + DS A
Sbjct: 332 VGGYPAVGAREDRMSHPSGPYSQASAAAPQPAAARQPPPPEEEEEEANSYDSD---EATT 388
Query: 972 LGQVKLTLWYYSEERKLVSIVHGCRSLR-QNGRDPPDPYVSLLLLPDKNRGTKRRTSQKK 1030
LG ++ +L Y + L + + L+ + DPYV L LLP ++ K RT +
Sbjct: 389 LGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLR 448
Query: 1031 RTLSPEFNERFEWELPLDE-AQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQ 1087
T +P +NE + DE QR+ L +SV F E +G+ + L + +Q
Sbjct: 449 NTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKF--GHNEFIGETRFSLKKLKPNQ 504
Score = 32.3 bits (72), Expect = 2.5
Identities = 22/76 (28%), Positives = 34/76 (44%), Gaps = 9/76 (11%)
Query: 672 GKSDPYVKLKL-----AGRSFRSHVVREDLNPRWNEVF---EVIVTSVPGQELEVEVFDK 723
G +DPYVKL L R+ +R NP WNE + + + L + V D+
Sbjct: 422 GLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDE 481
Query: 724 D-LDKDDFLGRCKVRL 738
D ++F+G + L
Sbjct: 482 DKFGHNEFIGETRFSL 497
>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
Length = 757
Score = 68.2 bits (165), Expect = 4e-11
Identities = 73/290 (25%), Positives = 125/290 (43%), Gaps = 59/290 (20%)
Query: 480 LVVYLDRAQDLPLKK--GNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQ 537
L + + ++LP K G+ +P +V++ + + + + V+ T CP W E ++ L P
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTA-TVWKTLCPFWGEEYQVHLP-PT 64
Query: 538 SQELDVQVKDD---SRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMR 594
+ V D+ SR +G + L + + P+ W L+ P+ + ++ +R
Sbjct: 65 FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGF-SGWAHLTEVDPDEEVQGEIHLR 123
Query: 595 ILYLDSSEICFPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHVLRIHVL 654
+ E+ PGA R C LR VL
Sbjct: 124 L------EVW-------PGA------------------RACR------------LRCSVL 140
Query: 655 EAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIVTSVPGQ 714
EA+DL KDR G SDP+V+++ GR+ + +V++ PRWNE FE + +
Sbjct: 141 EARDLAPKDR------NGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAME 194
Query: 715 ELEVEVFDKDL-DKDDFLGRCKVRLTTVLNSGFLDEWLTLE-DVPSGRLH 762
L VE +D DL ++DFLG+ + + + + W L+ D R H
Sbjct: 195 ALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRH 244
Score = 63.5 bits (153), Expect = 1e-09
Identities = 71/273 (26%), Positives = 116/273 (42%), Gaps = 48/273 (17%)
Query: 328 RGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFC-SRVIDEELNPQWGETY 386
R + I ++ + L +KD I G SDPY +V++ + + + + L P WGE Y
Sbjct: 4 RSSLYIRIVEGKNLPAKD------ITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEY 57
Query: 387 EVMVHEVPG-QEIEVEVFDKDP-DKDDFLGRMKLDVGKVLQA-------SVLDDWFPLQG 437
+V H P + V D+D +DD +G++ L + + L + P +
Sbjct: 58 QV--HLPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEE 115
Query: 438 GQGQVHLRLE-WLSLLSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQDLPLKKGN 496
QG++HLRLE W P + + L+ A+DL K N
Sbjct: 116 VQGEIHLRLEVW-----------------------PGARACRLRCSVLE-ARDLAPKDRN 151
Query: 497 KEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKD---DSRALT 553
+P V++ + T+E+ V + P W E F F LQ+ + L V+ D SR
Sbjct: 152 GTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDF 211
Query: 554 LGALTLPLARLLTAPELILDQWFQLSSSGPNSR 586
LG + + + RL + + WF+L SR
Sbjct: 212 LGKVVIDVQRLRVVQQ--EEGWFRLQPDQSKSR 242
Score = 40.4 bits (93), Expect = 0.009
Identities = 43/145 (29%), Positives = 67/145 (46%), Gaps = 12/145 (8%)
Query: 958 LTHVDSPLEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRD-PPDPYVSLLLLP 1016
LT VD P E G + ++L +W + +L V R L R+ DP+V +
Sbjct: 107 LTEVD-PDEEVQGEI-HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRV---- 160
Query: 1017 DKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKV 1076
+ +G R TS K++ P +NE FE+E L E L V + +SR + LGKV
Sbjct: 161 -RYKGRTRETSIVKKSCYPRWNETFEFE--LQEGAMEALCVEA-WDWDLVSR-NDFLGKV 215
Query: 1077 QLDLAETDLSQGVARWYDLMDNKDK 1101
+D+ + Q W+ L ++ K
Sbjct: 216 VIDVQRLRVVQQEEGWFRLQPDQSK 240
>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
Length = 803
Score = 68.2 bits (165), Expect = 4e-11
Identities = 73/290 (25%), Positives = 125/290 (43%), Gaps = 59/290 (20%)
Query: 480 LVVYLDRAQDLPLKK--GNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQ 537
L + + ++LP K G+ +P +V++ + + + + V+ T CP W E ++ L P
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTA-TVWKTLCPFWGEEYQVHLP-PT 64
Query: 538 SQELDVQVKDD---SRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMR 594
+ V D+ SR +G + L + + P+ W L+ P+ + ++ +R
Sbjct: 65 FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGF-SGWAHLTEVDPDEEVQGEIHLR 123
Query: 595 ILYLDSSEICFPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHVLRIHVL 654
+ E+ PGA R C LR VL
Sbjct: 124 L------EVW-------PGA------------------RACR------------LRCSVL 140
Query: 655 EAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIVTSVPGQ 714
EA+DL KDR G SDP+V+++ GR+ + +V++ PRWNE FE + +
Sbjct: 141 EARDLAPKDR------NGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAME 194
Query: 715 ELEVEVFDKDL-DKDDFLGRCKVRLTTVLNSGFLDEWLTLE-DVPSGRLH 762
L VE +D DL ++DFLG+ + + + + W L+ D R H
Sbjct: 195 ALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRH 244
Score = 63.5 bits (153), Expect = 1e-09
Identities = 71/273 (26%), Positives = 116/273 (42%), Gaps = 48/273 (17%)
Query: 328 RGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFC-SRVIDEELNPQWGETY 386
R + I ++ + L +KD I G SDPY +V++ + + + + L P WGE Y
Sbjct: 4 RSSLYIRIVEGKNLPAKD------ITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEY 57
Query: 387 EVMVHEVPG-QEIEVEVFDKDP-DKDDFLGRMKLDVGKVLQA-------SVLDDWFPLQG 437
+V H P + V D+D +DD +G++ L + + L + P +
Sbjct: 58 QV--HLPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEE 115
Query: 438 GQGQVHLRLE-WLSLLSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQDLPLKKGN 496
QG++HLRLE W P + + L+ A+DL K N
Sbjct: 116 VQGEIHLRLEVW-----------------------PGARACRLRCSVLE-ARDLAPKDRN 151
Query: 497 KEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKD---DSRALT 553
+P V++ + T+E+ V + P W E F F LQ+ + L V+ D SR
Sbjct: 152 GTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDF 211
Query: 554 LGALTLPLARLLTAPELILDQWFQLSSSGPNSR 586
LG + + + RL + + WF+L SR
Sbjct: 212 LGKVVIDVQRLRVVQQ--EEGWFRLQPDQSKSR 242
Score = 40.4 bits (93), Expect = 0.009
Identities = 43/145 (29%), Positives = 67/145 (46%), Gaps = 12/145 (8%)
Query: 958 LTHVDSPLEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRD-PPDPYVSLLLLP 1016
LT VD P E G + ++L +W + +L V R L R+ DP+V +
Sbjct: 107 LTEVD-PDEEVQGEI-HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRV---- 160
Query: 1017 DKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKV 1076
+ +G R TS K++ P +NE FE+E L E L V + +SR + LGKV
Sbjct: 161 -RYKGRTRETSIVKKSCYPRWNETFEFE--LQEGAMEALCVEA-WDWDLVSR-NDFLGKV 215
Query: 1077 QLDLAETDLSQGVARWYDLMDNKDK 1101
+D+ + Q W+ L ++ K
Sbjct: 216 VIDVQRLRVVQQEEGWFRLQPDQSK 240
>gi|6005997 double C2-like domains, beta [Homo sapiens]
Length = 412
Score = 68.2 bits (165), Expect = 4e-11
Identities = 40/130 (30%), Positives = 71/130 (54%), Gaps = 5/130 (3%)
Query: 973 GQVKLTLWYYSEERKL-VSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTKRRTSQKKR 1031
G++ ++L Y S+++ L V IV + DPYV L PD ++ +K +T+ KK+
Sbjct: 268 GRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKK 327
Query: 1032 TLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVAR 1091
TL+PEFNE F +E+ + ++ L+V+V + + + +G V L + + +
Sbjct: 328 TLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYD--IGKSNDFIGGVVLGIHAK--GERLKH 383
Query: 1092 WYDLMDNKDK 1101
W+D + NKDK
Sbjct: 384 WFDCLKNKDK 393
Score = 48.5 bits (114), Expect = 3e-05
Identities = 37/113 (32%), Positives = 54/113 (47%), Gaps = 8/113 (7%)
Query: 972 LGQVKLTLWYYSEERKL---VSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTKRRTSQ 1028
LG + +L Y E L ++ G + + NG DPYV L LLP ++ K RT
Sbjct: 127 LGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGL--ADPYVKLHLLPGASKANKLRTKT 184
Query: 1029 KKRTLSPEFNERFEWELPLDEAQRRK-LDVSVKSNSSFMSRERELLGKVQLDL 1080
+ TL+P +NE + DE RK L +SV F R E +G+ ++ L
Sbjct: 185 LRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKF--RHNEFIGETRVPL 235
Score = 39.7 bits (91), Expect = 0.016
Identities = 56/258 (21%), Positives = 96/258 (37%), Gaps = 44/258 (17%)
Query: 672 GKSDPYVKLKLA-----GRSFRSHVVREDLNPRWNEV---FEVIVTSVPGQELEVEVFDK 723
G +DPYVKL L R+ +R LNP WNE + + + + L + V D+
Sbjct: 160 GLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDE 219
Query: 724 D-LDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLTPRPTAAELEEVLQ 782
D ++F+G +V L L+ + ++ LE+ P + +
Sbjct: 220 DKFRHNEFIGETRVPLK------------KLKPNHTKTFNICLEKQLPVDKTEDKSLEER 267
Query: 783 VNSLIQTQKSAELAAALLSIYMERAEDLPLRKGTKHLSPYATLTV-----GDSSHKTKTI 837
LI + S++ L+ I R L + PY + S HKT
Sbjct: 268 GRILISLKYSSQKQGLLVGIV--RCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVK 325
Query: 838 SQTSAPVWDESASFLIRKPHTESLELQVR------GEGTGVLGSLSLPLS---------- 881
+T P ++E + I+ L+V G+ +G + L +
Sbjct: 326 KKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWF 385
Query: 882 ELLVADQLCLDRWFTLSS 899
+ L ++RW TL+S
Sbjct: 386 DCLKNKDKRIERWHTLTS 403
>gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Homo
sapiens]
Length = 306
Score = 66.6 bits (161), Expect = 1e-10
Identities = 38/95 (40%), Positives = 57/95 (60%), Gaps = 8/95 (8%)
Query: 648 VLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVI 707
+L++ VL+A DL+A D GKSDP+ L+L ++H V ++LNP WN+VF
Sbjct: 98 ILQVKVLKAADLLAAD------FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFP 151
Query: 708 VTSVPGQELEVEVFDKDLDK-DDFLGRCKVRLTTV 741
+ + LEV VFD+D DK DFLG+ + L ++
Sbjct: 152 IKDI-HDVLEVTVFDEDGDKPPDFLGKVAIPLLSI 185
Score = 55.5 bits (132), Expect = 3e-07
Identities = 30/91 (32%), Positives = 51/91 (56%), Gaps = 8/91 (8%)
Query: 329 GIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQWGETYEV 388
GI+++ +L A L + D GKSDP+ L+ LG + + + LNP+W + +
Sbjct: 97 GILQVKVLKAADLLAAD------FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTF 150
Query: 389 MVHEVPGQEIEVEVFDKDPDK-DDFLGRMKL 418
+ ++ +EV VFD+D DK DFLG++ +
Sbjct: 151 PIKDI-HDVLEVTVFDEDGDKPPDFLGKVAI 180
Score = 36.2 bits (82), Expect = 0.18
Identities = 45/182 (24%), Positives = 79/182 (43%), Gaps = 21/182 (11%)
Query: 398 IEVEVFDKDPDK-DDFLGRMKLDVGKV--LQASVLDDWFPLQGGQGQVHLRLEWLSL--- 451
+++EV+ KD K ++ LG K+D+ + QA+ L+ PL G + + +
Sbjct: 4 LDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLE--LPLDSCLGALLMLVTLTPCAGV 61
Query: 452 ---------LSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQDLPLKKGNKEPNPM 502
L+D + +Q+ Q +S D IL V + +A DL + + +P
Sbjct: 62 SVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPF 121
Query: 503 VQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKD---DSRALTLGALTL 559
L + + ++ VY P W + F F ++D L+V V D D LG + +
Sbjct: 122 CLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIH-DVLEVTVFDEDGDKPPDFLGKVAI 180
Query: 560 PL 561
PL
Sbjct: 181 PL 182
>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
[Homo sapiens]
Length = 1686
Score = 64.7 bits (156), Expect = 5e-10
Identities = 42/124 (33%), Positives = 68/124 (54%), Gaps = 5/124 (4%)
Query: 973 GQVKLTLWYYSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTKRRTSQKKRT 1032
G VKL++ Y + ++H + ++G DP +PYV LLPD ++ +KR+T ++T
Sbjct: 1561 GAVKLSI-SYRNGTLFIMVMHIKDLVTEDGADP-NPYVKTYLLPDNHKTSKRKTKISRKT 1618
Query: 1033 LSPEFNERFEWE-LPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVAR 1091
+P FNE + + ++R+L +SV S S RE LG V L L + +LS+ +
Sbjct: 1619 RNPTFNEMLVYSGYSKETLRQRELQLSVLSAESL--RENFFLGGVTLPLKDFNLSKETVK 1676
Query: 1092 WYDL 1095
WY L
Sbjct: 1677 WYQL 1680
>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 731
Score = 63.9 bits (154), Expect = 8e-10
Identities = 41/116 (35%), Positives = 62/116 (53%), Gaps = 8/116 (6%)
Query: 649 LRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIV 708
LR VLEA+DL KDR G SDP+V+++ GR+ + +V++ PRWNE FE +
Sbjct: 63 LRCSVLEARDLAPKDR------NGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFEL 116
Query: 709 TSVPGQELEVEVFDKDL-DKDDFLGRCKVRLTTVLNSGFLDEWLTLE-DVPSGRLH 762
+ L VE +D DL ++DFLG+ + + + + W L+ D R H
Sbjct: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRH 172
Score = 58.9 bits (141), Expect = 3e-08
Identities = 35/112 (31%), Positives = 60/112 (53%), Gaps = 7/112 (6%)
Query: 331 IRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQWGETYEVMV 390
+R +L AR L+ KD+ G SDP+ VR +T + ++ + P+W ET+E +
Sbjct: 63 LRCSVLEARDLAPKDR------NGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFEL 116
Query: 391 HEVPGQEIEVEVFDKD-PDKDDFLGRMKLDVGKVLQASVLDDWFPLQGGQGQ 441
E + + VE +D D ++DFLG++ +DV ++ + WF LQ Q +
Sbjct: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 168
Score = 40.8 bits (94), Expect = 0.007
Identities = 31/103 (30%), Positives = 48/103 (46%), Gaps = 5/103 (4%)
Query: 487 AQDLPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVK 546
A+DL K N +P V++ + T+E+ V + P W E F F LQ+ + L V+
Sbjct: 70 ARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAW 129
Query: 547 D---DSRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSR 586
D SR LG + + + RL + + WF+L SR
Sbjct: 130 DWDLVSRNDFLGKVVIDVQRLRVVQQ--EEGWFRLQPDQSKSR 170
Score = 40.4 bits (93), Expect = 0.009
Identities = 43/145 (29%), Positives = 67/145 (46%), Gaps = 12/145 (8%)
Query: 958 LTHVDSPLEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRD-PPDPYVSLLLLP 1016
LT VD P E G + ++L +W + +L V R L R+ DP+V +
Sbjct: 35 LTEVD-PDEEVQGEI-HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRV---- 88
Query: 1017 DKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKV 1076
+ +G R TS K++ P +NE FE+E L E L V + +SR + LGKV
Sbjct: 89 -RYKGRTRETSIVKKSCYPRWNETFEFE--LQEGAMEALCVEA-WDWDLVSR-NDFLGKV 143
Query: 1077 QLDLAETDLSQGVARWYDLMDNKDK 1101
+D+ + Q W+ L ++ K
Sbjct: 144 VIDVQRLRVVQQEEGWFRLQPDQSK 168
>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 731
Score = 63.9 bits (154), Expect = 8e-10
Identities = 41/116 (35%), Positives = 62/116 (53%), Gaps = 8/116 (6%)
Query: 649 LRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIV 708
LR VLEA+DL KDR G SDP+V+++ GR+ + +V++ PRWNE FE +
Sbjct: 63 LRCSVLEARDLAPKDR------NGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFEL 116
Query: 709 TSVPGQELEVEVFDKDL-DKDDFLGRCKVRLTTVLNSGFLDEWLTLE-DVPSGRLH 762
+ L VE +D DL ++DFLG+ + + + + W L+ D R H
Sbjct: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRH 172
Score = 58.9 bits (141), Expect = 3e-08
Identities = 35/112 (31%), Positives = 60/112 (53%), Gaps = 7/112 (6%)
Query: 331 IRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQWGETYEVMV 390
+R +L AR L+ KD+ G SDP+ VR +T + ++ + P+W ET+E +
Sbjct: 63 LRCSVLEARDLAPKDR------NGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFEL 116
Query: 391 HEVPGQEIEVEVFDKD-PDKDDFLGRMKLDVGKVLQASVLDDWFPLQGGQGQ 441
E + + VE +D D ++DFLG++ +DV ++ + WF LQ Q +
Sbjct: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 168
Score = 40.8 bits (94), Expect = 0.007
Identities = 31/103 (30%), Positives = 48/103 (46%), Gaps = 5/103 (4%)
Query: 487 AQDLPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVK 546
A+DL K N +P V++ + T+E+ V + P W E F F LQ+ + L V+
Sbjct: 70 ARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAW 129
Query: 547 D---DSRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSR 586
D SR LG + + + RL + + WF+L SR
Sbjct: 130 DWDLVSRNDFLGKVVIDVQRLRVVQQ--EEGWFRLQPDQSKSR 170
Score = 40.4 bits (93), Expect = 0.009
Identities = 43/145 (29%), Positives = 67/145 (46%), Gaps = 12/145 (8%)
Query: 958 LTHVDSPLEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRD-PPDPYVSLLLLP 1016
LT VD P E G + ++L +W + +L V R L R+ DP+V +
Sbjct: 35 LTEVD-PDEEVQGEI-HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRV---- 88
Query: 1017 DKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKV 1076
+ +G R TS K++ P +NE FE+E L E L V + +SR + LGKV
Sbjct: 89 -RYKGRTRETSIVKKSCYPRWNETFEFE--LQEGAMEALCVEA-WDWDLVSR-NDFLGKV 143
Query: 1077 QLDLAETDLSQGVARWYDLMDNKDK 1101
+D+ + Q W+ L ++ K
Sbjct: 144 VIDVQRLRVVQQEEGWFRLQPDQSK 168
>gi|45504376 synaptotagmin VI [Homo sapiens]
Length = 425
Score = 63.9 bits (154), Expect = 8e-10
Identities = 54/187 (28%), Positives = 88/187 (47%), Gaps = 10/187 (5%)
Query: 915 SQHSGVEAHSHSYSHSSSSL--SEEPELSGGPPHITSSAPEL-RQRLTHVDSPLEAPAGP 971
++H+ + H H SS +E P + P I PEL +Q+ +
Sbjct: 85 TRHTSFKRHLPRQMHVSSVDYGNELPPAAEQPTSIGRIKPELYKQKSVDGEDAKSEATKS 144
Query: 972 LGQVKLTLWY-YSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTKRRTSQKK 1030
G++ +L Y Y E +V I+ ++ DPYV + LLPD R K +T +
Sbjct: 145 CGKINFSLRYDYETETLIVRILKAFDLPAKDFCGSSDPYVKIYLLPD--RKCKLQTRVHR 202
Query: 1031 RTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLD--LAETDLSQG 1088
+TL+P F+E F + +P +E RKL +SV F +++G+V LD +DLS+
Sbjct: 203 KTLNPTFDENFHFPVPYEELADRKLHLSVFDFDRF--SRHDMIGEVILDNLFEASDLSRE 260
Query: 1089 VARWYDL 1095
+ W D+
Sbjct: 261 TSIWKDI 267
Score = 50.8 bits (120), Expect = 7e-06
Identities = 37/141 (26%), Positives = 66/141 (46%), Gaps = 15/141 (10%)
Query: 972 LGQVKLTLWYYSEERKLVSIVHGCRSLR-QNGRDPPDPYVSLLLLPDKNRGTKRRTSQKK 1030
LG++ +L Y +L V CR+L+ + DPYV + LL D R K++T+ KK
Sbjct: 277 LGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIKK 336
Query: 1031 RTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQG-- 1088
TL+P +NE +++P + + L +SV E++G ++ + L +
Sbjct: 337 NTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRV--GHNEIIGVCRVGITAEGLGRDHW 394
Query: 1089 ----------VARWYDLMDNK 1099
+A W+ L++ K
Sbjct: 395 NEMLAYPRKPIAHWHSLVEVK 415
Score = 38.1 bits (87), Expect = 0.046
Identities = 35/127 (27%), Positives = 61/127 (48%), Gaps = 15/127 (11%)
Query: 649 LRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLA--GRSF---RSHVVREDLNPRWNE- 702
L + V++ ++L A D + G SDPYVK+ L GR ++ + + LNP +NE
Sbjct: 293 LTLTVIKCRNLKAMD------ITGYSDPYVKVSLLCDGRRLKKKKTTIKKNTLNPVYNEA 346
Query: 703 -VFEVIVTSVPGQELEVEVFDKD-LDKDDFLGRCKVRLTTV-LNSGFLDEWLTLEDVPSG 759
+F++ ++ L + V D D + ++ +G C+V +T L +E L P
Sbjct: 347 IIFDIPPENMDQVSLLISVMDYDRVGHNEIIGVCRVGITAEGLGRDHWNEMLAYPRKPIA 406
Query: 760 RLHLRLE 766
H +E
Sbjct: 407 HWHSLVE 413
Score = 37.7 bits (86), Expect = 0.060
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 12/90 (13%)
Query: 649 LRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGR---SFRSHVVREDLNPRWNEVFE 705
L + +L+A DL AKD G SDPYVK+ L ++ V R+ LNP ++E F
Sbjct: 161 LIVRILKAFDLPAKD------FCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENFH 214
Query: 706 --VIVTSVPGQELEVEVFDKD-LDKDDFLG 732
V + ++L + VFD D + D +G
Sbjct: 215 FPVPYEELADRKLHLSVFDFDRFSRHDMIG 244
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 62.4 bits (150), Expect = 2e-09
Identities = 41/116 (35%), Positives = 63/116 (54%), Gaps = 6/116 (5%)
Query: 966 EAPAG-PLGQVKLTLWY-YSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTK 1023
EA G P G++ L Y Y ++ +V I+ ++ DPYV + LLPD+ + K
Sbjct: 293 EAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKK--K 350
Query: 1024 RRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLD 1079
+T ++TL+P FNE F++ +PL E +RKL SV F +L+G+V LD
Sbjct: 351 FQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRF--SRHDLIGQVVLD 404
Score = 45.4 bits (106), Expect = 3e-04
Identities = 58/234 (24%), Positives = 101/234 (43%), Gaps = 37/234 (15%)
Query: 643 FGTEHVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAG---RSFRSHVVREDLNPR 699
+G++ ++ + +L+A DL AKD G SDPYVK+ L + F++ V R+ LNP
Sbjct: 311 YGSDQLV-VRILQALDLPAKDS------NGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPV 363
Query: 700 WNEVFE--VIVTSVPGQELEVEVFDKD-LDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDV 756
+NE F+ V + + ++L V+D D + D +G+ LD L L +
Sbjct: 364 FNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQV-----------VLDNLLELAEQ 412
Query: 757 PSGRLHLRLERLTPRPTAAELEEVLQVNSLIQTQKSAELAAALLSIYMERAEDLPLRKGT 816
P R L + + A+L E+ + T A L++ + +A +L T
Sbjct: 413 PPDR-PLWRDIVEGGSEKADLGELNFSLCYLPT-------AGRLTVTIIKASNLKAMDLT 464
Query: 817 KHLSPYATLTVGD-----SSHKTKTISQTSAPVWDESASFLIRKPHTESLELQV 865
PY ++ KT T P ++E+ F + E++ L +
Sbjct: 465 GFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSI 518
Score = 43.9 bits (102), Expect = 8e-04
Identities = 34/131 (25%), Positives = 59/131 (45%), Gaps = 4/131 (3%)
Query: 972 LGQVKLTLWYYSEERKL-VSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTKRRTSQKK 1030
LG++ +L Y +L V+I+ + DPYV L+ + R KR+TS KK
Sbjct: 432 LGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKK 491
Query: 1031 RTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVA 1090
TL+P +NE +++ + + L ++V E + +V D A+ G
Sbjct: 492 NTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAAD---PHGRE 548
Query: 1091 RWYDLMDNKDK 1101
W +++ N K
Sbjct: 549 HWAEMLANPRK 559
>gi|238550196 synaptotagmin III [Homo sapiens]
Length = 590
Score = 62.4 bits (150), Expect = 2e-09
Identities = 41/116 (35%), Positives = 63/116 (54%), Gaps = 6/116 (5%)
Query: 966 EAPAG-PLGQVKLTLWY-YSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTK 1023
EA G P G++ L Y Y ++ +V I+ ++ DPYV + LLPD+ + K
Sbjct: 293 EAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKK--K 350
Query: 1024 RRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLD 1079
+T ++TL+P FNE F++ +PL E +RKL SV F +L+G+V LD
Sbjct: 351 FQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRF--SRHDLIGQVVLD 404
Score = 45.4 bits (106), Expect = 3e-04
Identities = 58/234 (24%), Positives = 101/234 (43%), Gaps = 37/234 (15%)
Query: 643 FGTEHVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAG---RSFRSHVVREDLNPR 699
+G++ ++ + +L+A DL AKD G SDPYVK+ L + F++ V R+ LNP
Sbjct: 311 YGSDQLV-VRILQALDLPAKDS------NGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPV 363
Query: 700 WNEVFE--VIVTSVPGQELEVEVFDKD-LDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDV 756
+NE F+ V + + ++L V+D D + D +G+ LD L L +
Sbjct: 364 FNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQV-----------VLDNLLELAEQ 412
Query: 757 PSGRLHLRLERLTPRPTAAELEEVLQVNSLIQTQKSAELAAALLSIYMERAEDLPLRKGT 816
P R L + + A+L E+ + T A L++ + +A +L T
Sbjct: 413 PPDR-PLWRDIVEGGSEKADLGELNFSLCYLPT-------AGRLTVTIIKASNLKAMDLT 464
Query: 817 KHLSPYATLTVGD-----SSHKTKTISQTSAPVWDESASFLIRKPHTESLELQV 865
PY ++ KT T P ++E+ F + E++ L +
Sbjct: 465 GFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSI 518
Score = 43.9 bits (102), Expect = 8e-04
Identities = 34/131 (25%), Positives = 59/131 (45%), Gaps = 4/131 (3%)
Query: 972 LGQVKLTLWYYSEERKL-VSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTKRRTSQKK 1030
LG++ +L Y +L V+I+ + DPYV L+ + R KR+TS KK
Sbjct: 432 LGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKK 491
Query: 1031 RTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVA 1090
TL+P +NE +++ + + L ++V E + +V D A+ G
Sbjct: 492 NTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAAD---PHGRE 548
Query: 1091 RWYDLMDNKDK 1101
W +++ N K
Sbjct: 549 HWAEMLANPRK 559
>gi|14150054 synaptotagmin III [Homo sapiens]
Length = 590
Score = 62.4 bits (150), Expect = 2e-09
Identities = 41/116 (35%), Positives = 63/116 (54%), Gaps = 6/116 (5%)
Query: 966 EAPAG-PLGQVKLTLWY-YSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTK 1023
EA G P G++ L Y Y ++ +V I+ ++ DPYV + LLPD+ + K
Sbjct: 293 EAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKK--K 350
Query: 1024 RRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLD 1079
+T ++TL+P FNE F++ +PL E +RKL SV F +L+G+V LD
Sbjct: 351 FQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRF--SRHDLIGQVVLD 404
Score = 45.4 bits (106), Expect = 3e-04
Identities = 58/234 (24%), Positives = 101/234 (43%), Gaps = 37/234 (15%)
Query: 643 FGTEHVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAG---RSFRSHVVREDLNPR 699
+G++ ++ + +L+A DL AKD G SDPYVK+ L + F++ V R+ LNP
Sbjct: 311 YGSDQLV-VRILQALDLPAKDS------NGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPV 363
Query: 700 WNEVFE--VIVTSVPGQELEVEVFDKD-LDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDV 756
+NE F+ V + + ++L V+D D + D +G+ LD L L +
Sbjct: 364 FNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQV-----------VLDNLLELAEQ 412
Query: 757 PSGRLHLRLERLTPRPTAAELEEVLQVNSLIQTQKSAELAAALLSIYMERAEDLPLRKGT 816
P R L + + A+L E+ + T A L++ + +A +L T
Sbjct: 413 PPDR-PLWRDIVEGGSEKADLGELNFSLCYLPT-------AGRLTVTIIKASNLKAMDLT 464
Query: 817 KHLSPYATLTVGD-----SSHKTKTISQTSAPVWDESASFLIRKPHTESLELQV 865
PY ++ KT T P ++E+ F + E++ L +
Sbjct: 465 GFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSI 518
Score = 43.9 bits (102), Expect = 8e-04
Identities = 34/131 (25%), Positives = 59/131 (45%), Gaps = 4/131 (3%)
Query: 972 LGQVKLTLWYYSEERKL-VSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTKRRTSQKK 1030
LG++ +L Y +L V+I+ + DPYV L+ + R KR+TS KK
Sbjct: 432 LGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKK 491
Query: 1031 RTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVA 1090
TL+P +NE +++ + + L ++V E + +V D A+ G
Sbjct: 492 NTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAAD---PHGRE 548
Query: 1091 RWYDLMDNKDK 1101
W +++ N K
Sbjct: 549 HWAEMLANPRK 559
>gi|39752671 synaptotagmin X [Homo sapiens]
Length = 523
Score = 62.0 bits (149), Expect = 3e-09
Identities = 55/190 (28%), Positives = 86/190 (45%), Gaps = 13/190 (6%)
Query: 915 SQHSGVEAHSHSYSHSSS---SLSEEPELSGGPP--HITSSAPEL-RQRLTHVDSPLEAP 968
++HS H SS S+ EP L G I PEL +Q+ +
Sbjct: 169 TRHSSFRRHLPRQMQVSSVDFSMGTEPVLQRGETTTSIGRIKPELYKQKSVDSEGNQNED 228
Query: 969 AGPLGQVKLTLWY-YSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTKRRTS 1027
G++ TL Y Y E +V I+ ++ DPYV + LLPD+ + K +T
Sbjct: 229 VKICGKLNFTLQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKMYLLPDRKK--KFQTR 286
Query: 1028 QKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLD--LAETDL 1085
++TL+P F+E F++ + D+ RKL SV F +++G+V LD +DL
Sbjct: 287 VHRKTLNPLFDETFQFPVAYDQLSNRKLHFSVYDFDRF--SRHDMIGEVILDNLFEVSDL 344
Query: 1086 SQGVARWYDL 1095
S+ W D+
Sbjct: 345 SREATVWKDI 354
Score = 50.4 bits (119), Expect = 9e-06
Identities = 27/89 (30%), Positives = 49/89 (55%), Gaps = 1/89 (1%)
Query: 972 LGQVKLTLWYYSEERKLVSIVHGCRSLR-QNGRDPPDPYVSLLLLPDKNRGTKRRTSQKK 1030
LG++ +L Y ++ V CR+L+ + DPYV + L+ + R KR+T+ KK
Sbjct: 364 LGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTTTKK 423
Query: 1031 RTLSPEFNERFEWELPLDEAQRRKLDVSV 1059
TL+P +NE +++P + + L ++V
Sbjct: 424 NTLNPVYNEAIIFDIPPENVDQVSLSIAV 452
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/91 (32%), Positives = 49/91 (53%), Gaps = 12/91 (13%)
Query: 648 VLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAG---RSFRSHVVREDLNPRWNEVF 704
+L + +++A DL AKD G SDPYVK+ L + F++ V R+ LNP ++E F
Sbjct: 247 LLVVKIIKALDLPAKD------FTGTSDPYVKMYLLPDRKKKFQTRVHRKTLNPLFDETF 300
Query: 705 E--VIVTSVPGQELEVEVFDKD-LDKDDFLG 732
+ V + ++L V+D D + D +G
Sbjct: 301 QFPVAYDQLSNRKLHFSVYDFDRFSRHDMIG 331
Score = 37.4 bits (85), Expect = 0.079
Identities = 68/303 (22%), Positives = 119/303 (39%), Gaps = 64/303 (21%)
Query: 479 ILVVYLDRAQDLPLKKGNKEPNPMVQLSIQDVTQ---ESKAVYSTNCPVWEEAFRFFLQD 535
+LVV + +A DLP K +P V++ + + +++ T P+++E F+F +
Sbjct: 247 LLVVKIIKALDLPAKDFTGTSDPYVKMYLLPDRKKKFQTRVHRKTLNPLFDETFQFPVAY 306
Query: 536 PQ--SQELDVQVKDDSRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVM 593
Q +++L V D R +R E+ILD F++S + ++ +
Sbjct: 307 DQLSNRKLHFSVYDFDR----------FSRHDMIGEVILDNLFEVSDLSREATVWKDIHC 356
Query: 594 RILY-LDSSEICFPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHVLRIH 652
+D EI F C+ T + +
Sbjct: 357 ATTESIDLGEIMFSL---------------------------CYLP------TAGRMTLT 383
Query: 653 VLEAQDLIAKDRFLGGLVKGKSDPYVKLKL--AGRSFRSH---VVREDLNPRWNE--VFE 705
V++ ++L A D + G SDPYVK+ L GR + + LNP +NE +F+
Sbjct: 384 VIKCRNLKAMD------ITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFD 437
Query: 706 VIVTSVPGQELEVEVFDKD-LDKDDFLGRCKVRLTTV-LNSGFLDEWLTLEDVPSGRLHL 763
+ +V L + V D D + ++ +G C+ L L +E L P H
Sbjct: 438 IPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEMLAYHRKPITHWHP 497
Query: 764 RLE 766
LE
Sbjct: 498 LLE 500
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 61.2 bits (147), Expect = 5e-09
Identities = 35/123 (28%), Positives = 66/123 (53%), Gaps = 11/123 (8%)
Query: 649 LRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIV 708
L +HV+EA +L A GKS+PY ++ + +S+ + +++ LNP+WN + +
Sbjct: 1544 LMVHVIEATELKACKP------NGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFI 1597
Query: 709 TSVPGQELEVEVFDKD-LDKDDFLGRCKVRLTTVL----NSGFLDEWLTLEDVPSGRLHL 763
+ L + +FD+D DDFLGR ++ + + + G + L L +VP+G + +
Sbjct: 1598 KDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTGEVWV 1657
Query: 764 RLE 766
R +
Sbjct: 1658 RFD 1660
Score = 56.2 bits (134), Expect = 2e-07
Identities = 33/106 (31%), Positives = 57/106 (53%), Gaps = 9/106 (8%)
Query: 321 QLRSPLPRGIIR--IHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEEL 378
Q RS GI R +H++ A L + GKS+PY + +G+Q++ +R I + L
Sbjct: 1532 QARSQKTSGIGRLMVHVIEATELKACKP------NGKSNPYCEISMGSQSYTTRTIQDTL 1585
Query: 379 NPQWGETYEVMVHEVPGQEIEVEVFDKDP-DKDDFLGRMKLDVGKV 423
NP+W + + ++ + + +FD+D DDFLGR ++ V K+
Sbjct: 1586 NPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKI 1631
Score = 36.2 bits (82), Expect = 0.18
Identities = 17/62 (27%), Positives = 32/62 (51%)
Query: 800 LSIYMERAEDLPLRKGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIRKPHTE 859
L +++ A +L K +PY +++G S+ T+TI T P W+ + F I+ + +
Sbjct: 1544 LMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQD 1603
Query: 860 SL 861
L
Sbjct: 1604 VL 1605
Score = 35.4 bits (80), Expect = 0.30
Identities = 23/93 (24%), Positives = 45/93 (48%), Gaps = 3/93 (3%)
Query: 480 LVVYLDRAQDLPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQ 539
L+V++ A +L K N + NP ++S+ + ++ + T P W +FF++D
Sbjct: 1544 LMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQD 1603
Query: 540 ELDVQVKDDSRALT---LGALTLPLARLLTAPE 569
L + + D + LG +P+A++ T E
Sbjct: 1604 VLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQE 1636
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 61.2 bits (147), Expect = 5e-09
Identities = 35/123 (28%), Positives = 66/123 (53%), Gaps = 11/123 (8%)
Query: 649 LRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIV 708
L +HV+EA +L A GKS+PY ++ + +S+ + +++ LNP+WN + +
Sbjct: 1571 LMVHVIEATELKACKP------NGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFI 1624
Query: 709 TSVPGQELEVEVFDKD-LDKDDFLGRCKVRLTTVL----NSGFLDEWLTLEDVPSGRLHL 763
+ L + +FD+D DDFLGR ++ + + + G + L L +VP+G + +
Sbjct: 1625 KDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTGEVWV 1684
Query: 764 RLE 766
R +
Sbjct: 1685 RFD 1687
Score = 56.2 bits (134), Expect = 2e-07
Identities = 33/106 (31%), Positives = 57/106 (53%), Gaps = 9/106 (8%)
Query: 321 QLRSPLPRGIIR--IHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEEL 378
Q RS GI R +H++ A L + GKS+PY + +G+Q++ +R I + L
Sbjct: 1559 QARSQKTSGIGRLMVHVIEATELKACKP------NGKSNPYCEISMGSQSYTTRTIQDTL 1612
Query: 379 NPQWGETYEVMVHEVPGQEIEVEVFDKDP-DKDDFLGRMKLDVGKV 423
NP+W + + ++ + + +FD+D DDFLGR ++ V K+
Sbjct: 1613 NPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKI 1658
Score = 36.2 bits (82), Expect = 0.18
Identities = 17/62 (27%), Positives = 32/62 (51%)
Query: 800 LSIYMERAEDLPLRKGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIRKPHTE 859
L +++ A +L K +PY +++G S+ T+TI T P W+ + F I+ + +
Sbjct: 1571 LMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQD 1630
Query: 860 SL 861
L
Sbjct: 1631 VL 1632
Score = 35.4 bits (80), Expect = 0.30
Identities = 23/93 (24%), Positives = 45/93 (48%), Gaps = 3/93 (3%)
Query: 480 LVVYLDRAQDLPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQ 539
L+V++ A +L K N + NP ++S+ + ++ + T P W +FF++D
Sbjct: 1571 LMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQD 1630
Query: 540 ELDVQVKDDSRALT---LGALTLPLARLLTAPE 569
L + + D + LG +P+A++ T E
Sbjct: 1631 VLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQE 1663
>gi|47078261 double C2-like domains, alpha [Homo sapiens]
Length = 400
Score = 60.1 bits (144), Expect = 1e-08
Identities = 44/133 (33%), Positives = 67/133 (50%), Gaps = 13/133 (9%)
Query: 973 GQVKLTLWYYSEERKLVSIVHGCRSLRQ---NGRDPPDPYVSLLLLPDKNRGTKRRTSQK 1029
G++ L+L Y S R L+ + C L NG DPYV L PD ++ +K +T K
Sbjct: 253 GRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYS--DPYVKTYLRPDVDKKSKHKTCVK 310
Query: 1030 KRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGV 1089
K+TL+PEFNE F +E+ L + L+V+V + + + +G V L ++G
Sbjct: 311 KKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYD--IGKSNDFIGGVSLGPG----ARGE 364
Query: 1090 AR--WYDLMDNKD 1100
AR W D + D
Sbjct: 365 ARKHWSDCLQQPD 377
Score = 41.6 bits (96), Expect = 0.004
Identities = 32/92 (34%), Positives = 49/92 (53%), Gaps = 14/92 (15%)
Query: 649 LRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAG-----RSFRSHVVREDLNPRWNEV 703
L + +L L A D V G SDPYVK L ++ V ++ LNP +NE
Sbjct: 268 LLVGILRCAHLAAMD------VNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEE 321
Query: 704 F--EVIVTSVPGQELEVEVFDKDLDK-DDFLG 732
F E+ ++++ + LEV V+D D+ K +DF+G
Sbjct: 322 FFYEIELSTLATKTLEVTVWDYDIGKSNDFIG 353
Score = 40.4 bits (93), Expect = 0.009
Identities = 37/134 (27%), Positives = 56/134 (41%), Gaps = 14/134 (10%)
Query: 961 VDSPLEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRDP------PDPYVSLLL 1014
VDS A LG ++ L Y S C LR G P DPYV L L
Sbjct: 79 VDSYDSDDATALGTLEFDLLY-----DRASCTLHCSILRAKGLKPMDFNGLADPYVKLHL 133
Query: 1015 LPDKNRGTKRRTSQKKRTLSPEFNERFEWE-LPLDEAQRRKLDVSVKSNSSFMSRERELL 1073
LP + K +T ++ TL+P +NE + + D+ + L ++V E +
Sbjct: 134 LPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKL--SHNEFI 191
Query: 1074 GKVQLDLAETDLSQ 1087
G++++ L SQ
Sbjct: 192 GEIRVPLRRLKPSQ 205
Score = 39.7 bits (91), Expect = 0.016
Identities = 64/280 (22%), Positives = 104/280 (37%), Gaps = 66/280 (23%)
Query: 672 GKSDPYVKLKL-----AGRSFRSHVVREDLNPRWNEVFE---VIVTSVPGQELEVEVFDK 723
G +DPYVKL L ++ R LNP WNE + + + L + V D+
Sbjct: 123 GLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDE 182
Query: 724 D-LDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLR--LERLTPRPTAAELEEV 780
D L ++F+G +V L + PS + H LER P + + +
Sbjct: 183 DKLSHNEFIGEIRVPLRRL--------------KPSQKKHFNICLERQVPLASPSSMSAA 228
Query: 781 LQ-VNSLIQTQKSAELAAALLS-------------------IYMERAEDLPLRKGTKHLS 820
L+ ++ ++ + AE LL + + R L +
Sbjct: 229 LRGISCYLKELEQAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSD 288
Query: 821 PYATLTV-----GDSSHKTKTISQTSAPVWDESASFLIRKP--HTESLELQV----RGEG 869
PY + S HKT +T P ++E + I T++LE+ V G+
Sbjct: 289 PYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKS 348
Query: 870 TGVLGSLSL----------PLSELLVADQLCLDRWFTLSS 899
+G +SL S+ L L+RW TL+S
Sbjct: 349 NDFIGGVSLGPGARGEARKHWSDCLQQPDAALERWHTLTS 388
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,630,219
Number of Sequences: 37866
Number of extensions: 2298622
Number of successful extensions: 15097
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 149
Number of HSP's successfully gapped in prelim test: 212
Number of HSP's that attempted gapping in prelim test: 12420
Number of HSP's gapped (non-prelim): 2661
length of query: 1104
length of database: 18,247,518
effective HSP length: 113
effective length of query: 991
effective length of database: 13,968,660
effective search space: 13842942060
effective search space used: 13842942060
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.