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Search of human proteins with 89191863
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
(367 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 746 0.0
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 727 0.0
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] 384 e-107
gi|4503385 dopamine receptor D2 isoform long [Homo sapiens] 268 6e-72
gi|32483397 dopamine receptor D4 [Homo sapiens] 256 2e-68
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 203 2e-52
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 198 6e-51
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 198 6e-51
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 198 6e-51
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 198 6e-51
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 198 6e-51
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 194 1e-49
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 192 5e-49
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 191 7e-49
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 191 7e-49
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 191 7e-49
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 191 1e-48
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 190 2e-48
gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens] 189 3e-48
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] 183 2e-46
gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap... 181 7e-46
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 179 3e-45
gi|4503383 dopamine receptor D1 [Homo sapiens] 177 2e-44
gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa... 172 6e-43
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 170 2e-42
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 168 6e-42
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 167 1e-41
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 166 2e-41
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 166 2e-41
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 166 2e-41
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 746 bits (1925), Expect = 0.0
Identities = 367/367 (100%), Positives = 367/367 (100%)
Query: 1 MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL 60
MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
Sbjct: 1 MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL 60
Query: 61 QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN 120
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
Sbjct: 61 QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN 120
Query: 121 LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV 180
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
Sbjct: 121 LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV 180
Query: 181 CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ 240
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
Sbjct: 181 CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ 240
Query: 241 QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLMPLREKKATQMVAI 300
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLMPLREKKATQMVAI
Sbjct: 241 QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLMPLREKKATQMVAI 300
Query: 301 VLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKA 360
VLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKA
Sbjct: 301 VLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKA 360
Query: 361 FLKILSC 367
FLKILSC
Sbjct: 361 FLKILSC 367
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 727 bits (1877), Expect = 0.0
Identities = 366/400 (91%), Positives = 367/400 (91%), Gaps = 33/400 (8%)
Query: 1 MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL 60
MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
Sbjct: 1 MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL 60
Query: 61 QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN 120
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
Sbjct: 61 QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN 120
Query: 121 LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV 180
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
Sbjct: 121 LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV 180
Query: 181 CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ 240
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
Sbjct: 181 CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ 240
Query: 241 QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSL-------------- 286
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSL
Sbjct: 241 QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK 300
Query: 287 -------------------MPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV 327
+PLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
Sbjct: 301 LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV 360
Query: 328 SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
Sbjct: 361 SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400
>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
Length = 414
Score = 384 bits (987), Expect = e-107
Identities = 223/407 (54%), Positives = 261/407 (64%), Gaps = 73/407 (17%)
Query: 19 NSTGASQARPHA-YYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLL 77
N + RPH YYA LI IVFGN LVCMAV +E+ALQTTTNYL+VSLAVADLL
Sbjct: 23 NGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLL 82
Query: 78 VATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVH 137
VATLVMPWVVYLEV G W FSRI CD+FVTLDVMMCTASILNLCAISIDRYTAV MP+
Sbjct: 83 VATLVMPWVVYLEVV-GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPML 141
Query: 138 YQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSF 197
Y T SS RRV +MI+ VWVL+F +SCPLLFG N D C I+NP FV+YSS+VSF
Sbjct: 142 Y--NTRYSSKRRVTVMISIVWVLSFTISCPLLFGLN-NADQNECIIANPAFVVYSSIVSF 198
Query: 198 YLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQC-------------------------- 231
Y+PF VT+LVY +IY+VL+ RRRKR+ T+++S+
Sbjct: 199 YVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSS 257
Query: 232 ---------NSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREE-- 280
+ + P Q TL PDP+H L + P E+ G K
Sbjct: 258 TSPPERTRYSPIPPSHHQLTL-PDPSHHGL--------HSTPDSPAKPEKNGHAKDHPKI 308
Query: 281 ------------KTRNSLMPL--------REKKATQMVAIVLGAFIVCWLPFFLTHVLNT 320
KTR SL + +EKKATQM+AIVLG FI+CWLPFF+TH+LN
Sbjct: 309 AKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNI 368
Query: 321 HCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
HC C++ P LYSA TWLGYVNSA+NP+IYTTFNIEFRKAFLKIL C
Sbjct: 369 HCD-CNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 414
>gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]
Length = 443
Score = 268 bits (685), Expect = 6e-72
Identities = 144/213 (67%), Positives = 167/213 (78%), Gaps = 6/213 (2%)
Query: 19 NSTGASQARPHA-YYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLL 77
N + RPH YYA LI IVFGN LVCMAV +E+ALQTTTNYL+VSLAVADLL
Sbjct: 23 NGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLL 82
Query: 78 VATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVH 137
VATLVMPWVVYLEV G W FSRI CD+FVTLDVMMCTASILNLCAISIDRYTAV MP+
Sbjct: 83 VATLVMPWVVYLEVV-GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPML 141
Query: 138 YQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSF 197
Y T SS RRV +MI+ VWVL+F +SCPLLFG N D C I+NP FV+YSS+VSF
Sbjct: 142 Y--NTRYSSKRRVTVMISIVWVLSFTISCPLLFGLN-NADQNECIIANPAFVVYSSIVSF 198
Query: 198 YLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQ 230
Y+PF VT+LVY +IY+VL+ RRRKR+ T+++S+
Sbjct: 199 YVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSR 230
Score = 139 bits (350), Expect = 4e-33
Identities = 79/163 (48%), Positives = 97/163 (59%), Gaps = 32/163 (19%)
Query: 227 QNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEK----- 281
+ ++ + + P Q TL PDP+H L + P E+ G K K
Sbjct: 291 ERTRYSPIPPSHHQLTL-PDPSHHGLH--------STPDSPAKPEKNGHAKDHPKIAKIF 341
Query: 282 ---------TRNSLMPL--------REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQT 324
TR SL + +EKKATQM+AIVLG FI+CWLPFF+TH+LN HC
Sbjct: 342 EIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD- 400
Query: 325 CHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
C++ P LYSA TWLGYVNSA+NP+IYTTFNIEFRKAFLKIL C
Sbjct: 401 CNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 443
>gi|32483397 dopamine receptor D4 [Homo sapiens]
Length = 419
Score = 256 bits (654), Expect = 2e-68
Identities = 158/398 (39%), Positives = 205/398 (51%), Gaps = 51/398 (12%)
Query: 16 GAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVAD 75
GA A A A + LI A++ GN LVC++V ERALQT TN +VSLA AD
Sbjct: 21 GASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAAD 80
Query: 76 LLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMP 135
LL+A LV+P VY EV GG W S CD + +DVM+CTASI NLCAIS+DR+ AV +P
Sbjct: 81 LLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVP 140
Query: 136 VHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT--GDPTVCSISNPDFVIYSS 193
+ Y Q RR L+I A W+L+ AV+ P+L G N DP VC + + D+V+YSS
Sbjct: 141 LRYNR---QGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSS 197
Query: 194 VVSFYLPFGVTVLVYARIYVVLKQ---RRRKRILTRQ----------------------- 227
V SF+LP + +L+Y + L++ RR ++ R
Sbjct: 198 VCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDP 257
Query: 228 -NSQCNSVRPGFPQQTLSPDPAHLELKRYYSIC-QDTALGGPGF--QERGGELKREEKTR 283
C PG P+ PD A C D A PG G + R
Sbjct: 258 CGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVR 317
Query: 284 NSLMPL----------------REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV 327
+ +P RE+KA +++ +V+GAF++CW PFF+ H+ C C V
Sbjct: 318 AAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSV 377
Query: 328 SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 365
P L SA TWLGYVNSALNPVIYT FN EFR F K L
Sbjct: 378 PPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKAL 415
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 203 bits (517), Expect = 2e-52
Identities = 130/404 (32%), Positives = 200/404 (49%), Gaps = 65/404 (16%)
Query: 19 NSTGASQARP--HAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADL 76
N+TG S +L LI V GN V A+ ER+LQ NYL+ SLAV DL
Sbjct: 24 NTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDL 83
Query: 77 LVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPV 136
+V+ LV+P +V W ++ CD+F+ LDV+ CT+SIL+LCAI++DRY A+ P+
Sbjct: 84 MVSVLVLPMAALYQVLNK-WTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPI 142
Query: 137 HYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNT---TGDPTVCSIS-NPDFVIYS 192
Y + + RR A +I+ W++ F +S P + G+ T DP C+IS + + IYS
Sbjct: 143 DY---VNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYS 199
Query: 193 SVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAH--- 249
+ +FY+P + +++Y RI+ + R RK + + + ++ P +P P
Sbjct: 200 TFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASP----APQPKKSVN 255
Query: 250 -----------LELKRYYSICQDTALG--------------------------------- 265
+E K ++C + A+
Sbjct: 256 GESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTP 315
Query: 266 -GPGFQERGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQ- 323
P ER E E K + +L RE+K + + I++G FI+CWLPFF+ ++ C+
Sbjct: 316 CAPASFERKNERNAEAKRKMAL--ARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCES 373
Query: 324 TCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
+CH+ L + WLGY NS LNPVIY FN +F+ AF KI+ C
Sbjct: 374 SCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKC 417
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 198 bits (504), Expect = 6e-51
Identities = 120/333 (36%), Positives = 179/333 (53%), Gaps = 33/333 (9%)
Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
LIL V GN LV ++V R L + T+Y +V+LAVADLL+ + V+P+ EV G W F
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAF 94
Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
R+ C+++ +DV+ CTASI+ LC ISIDRY V P+ Y Q RR + + VW
Sbjct: 95 GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ---RRGLMALLCVW 151
Query: 159 VLAFAVSCPLLFGFNTTG--DPTVCSISN-PDFVIYSSVVSFYLPFGVTVLVYARIYVVL 215
L+ +S LFG+ D T+C I+ P +V++S++ SFYLP + +++Y R+YVV
Sbjct: 152 ALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211
Query: 216 KQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGE 275
K+ R ++ G + L + R ++ GG G
Sbjct: 212 KRESR------------GLKSGLKTDKSDSEQVTLRIHR-----KNAPAGGSGMASA--- 251
Query: 276 LKREEKTRNSLMPL---REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELY 332
+ KT S+ L REKKA + + IV+G F++CWLPFFL + + S ++
Sbjct: 252 ---KTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVF 308
Query: 333 SATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 365
WLGY+NS +NP+IY + EF+KAF +L
Sbjct: 309 KIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 198 bits (504), Expect = 6e-51
Identities = 120/333 (36%), Positives = 179/333 (53%), Gaps = 33/333 (9%)
Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
LIL V GN LV ++V R L + T+Y +V+LAVADLL+ + V+P+ EV G W F
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAF 94
Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
R+ C+++ +DV+ CTASI+ LC ISIDRY V P+ Y Q RR + + VW
Sbjct: 95 GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ---RRGLMALLCVW 151
Query: 159 VLAFAVSCPLLFGFNTTG--DPTVCSISN-PDFVIYSSVVSFYLPFGVTVLVYARIYVVL 215
L+ +S LFG+ D T+C I+ P +V++S++ SFYLP + +++Y R+YVV
Sbjct: 152 ALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211
Query: 216 KQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGE 275
K+ R ++ G + L + R ++ GG G
Sbjct: 212 KRESR------------GLKSGLKTDKSDSEQVTLRIHR-----KNAPAGGSGMASA--- 251
Query: 276 LKREEKTRNSLMPL---REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELY 332
+ KT S+ L REKKA + + IV+G F++CWLPFFL + + S ++
Sbjct: 252 ---KTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVF 308
Query: 333 SATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 365
WLGY+NS +NP+IY + EF+KAF +L
Sbjct: 309 KIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 198 bits (504), Expect = 6e-51
Identities = 120/333 (36%), Positives = 179/333 (53%), Gaps = 33/333 (9%)
Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
LIL V GN LV ++V R L + T+Y +V+LAVADLL+ + V+P+ EV G W F
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAF 94
Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
R+ C+++ +DV+ CTASI+ LC ISIDRY V P+ Y Q RR + + VW
Sbjct: 95 GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ---RRGLMALLCVW 151
Query: 159 VLAFAVSCPLLFGFNTTG--DPTVCSISN-PDFVIYSSVVSFYLPFGVTVLVYARIYVVL 215
L+ +S LFG+ D T+C I+ P +V++S++ SFYLP + +++Y R+YVV
Sbjct: 152 ALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211
Query: 216 KQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGE 275
K+ R ++ G + L + R ++ GG G
Sbjct: 212 KRESR------------GLKSGLKTDKSDSEQVTLRIHR-----KNAPAGGSGMASA--- 251
Query: 276 LKREEKTRNSLMPL---REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELY 332
+ KT S+ L REKKA + + IV+G F++CWLPFFL + + S ++
Sbjct: 252 ---KTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVF 308
Query: 333 SATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 365
WLGY+NS +NP+IY + EF+KAF +L
Sbjct: 309 KIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 198 bits (504), Expect = 6e-51
Identities = 120/333 (36%), Positives = 179/333 (53%), Gaps = 33/333 (9%)
Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
LIL V GN LV ++V R L + T+Y +V+LAVADLL+ + V+P+ EV G W F
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAF 94
Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
R+ C+++ +DV+ CTASI+ LC ISIDRY V P+ Y Q RR + + VW
Sbjct: 95 GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ---RRGLMALLCVW 151
Query: 159 VLAFAVSCPLLFGFNTTG--DPTVCSISN-PDFVIYSSVVSFYLPFGVTVLVYARIYVVL 215
L+ +S LFG+ D T+C I+ P +V++S++ SFYLP + +++Y R+YVV
Sbjct: 152 ALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211
Query: 216 KQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGE 275
K+ R ++ G + L + R ++ GG G
Sbjct: 212 KRESR------------GLKSGLKTDKSDSEQVTLRIHR-----KNAPAGGSGMASA--- 251
Query: 276 LKREEKTRNSLMPL---REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELY 332
+ KT S+ L REKKA + + IV+G F++CWLPFFL + + S ++
Sbjct: 252 ---KTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVF 308
Query: 333 SATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 365
WLGY+NS +NP+IY + EF+KAF +L
Sbjct: 309 KIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 198 bits (504), Expect = 6e-51
Identities = 124/336 (36%), Positives = 176/336 (52%), Gaps = 27/336 (8%)
Query: 38 ALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWN 97
A IL V GN LV ++V R LQT TNY +V+LAVADLL++ V+P+ +EV G W
Sbjct: 105 AFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLG-FWA 163
Query: 98 FSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAV 157
F R CDV+ +DV+ CTASIL+LC IS+DRY V + Y + R+ A ++ +
Sbjct: 164 FGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTE---RKAAAILALL 220
Query: 158 WVLAFAVSCPLLFGFN--TTGDPTVCSISNP-DFVIYSSVVSFYLPFGVTVLVYARIYVV 214
WV+A VS L G+ D C I+ + ++SSV SFYLP V V++Y R+YVV
Sbjct: 221 WVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVV 280
Query: 215 LKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPG---FQE 271
+ R S+ G ++ L + C+ A G G +
Sbjct: 281 ARSTTR------------SLEAGVKRERGKASEVVLRIH-----CRGAATGADGAHGMRS 323
Query: 272 RGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPEL 331
G R + L REKKA + +AIV+G F++CW PFF L + S +
Sbjct: 324 AKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGV 383
Query: 332 YSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
+ WLGY NS +NP+IY + EF++AFL++L C
Sbjct: 384 FKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRC 419
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 194 bits (493), Expect = 1e-49
Identities = 120/339 (35%), Positives = 178/339 (52%), Gaps = 15/339 (4%)
Query: 33 ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVT 92
A+ + LA V N V +L R L T NYL+ SLA DLLV+ LVMP + +T
Sbjct: 42 AVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTIT 101
Query: 93 GGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVAL 152
WNF +I CD++++ D+ CTASIL+LC I++DRY A+ + Y + + + A
Sbjct: 102 H-TWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEY---SKRRTAGHAAT 157
Query: 153 MITAVWVLAFAVSCPLLFGFNTTG----DPTVCSISNPDFVIYSSVVSFYLPFGVTVLVY 208
MI VW ++ +S P LF + + S + IYS+ +FY+P + +++Y
Sbjct: 158 MIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILY 217
Query: 209 ARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP- 267
RIY + R RIL + T S + L + G P
Sbjct: 218 GRIY----RAARNRILNPPSLYGKRFTTAH-LITGSAGSSLCSLNSSLHEGHSHSAGSPL 272
Query: 268 GFQERGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQ-TCH 326
F +L R + RE+KAT+++ I+LGAFI+CWLPFF+ ++ C+ +C
Sbjct: 273 FFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCW 332
Query: 327 VSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 365
+ P L+ TWLGY+NS +NP+IYT FN EFR+AF KI+
Sbjct: 333 IHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 192 bits (487), Expect = 5e-49
Identities = 119/333 (35%), Positives = 181/333 (54%), Gaps = 24/333 (7%)
Query: 38 ALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWN 97
A IL + GN LV ++V R L+T TNY +V+LA+ADLL++ V+P+ LEV G W
Sbjct: 54 AFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLG-YWV 112
Query: 98 FSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAV 157
RI CD++ +DV+ CTASIL+LCAISIDRY V + Y + R+ L + +V
Sbjct: 113 LGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTR---RKAILALLSV 169
Query: 158 WVLAFAVSCPLLFGFN--TTGDPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVV 214
WVL+ +S L G+ D C ++ P + ++SS+ SFY+P V +++Y R+Y+V
Sbjct: 170 WVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIV 229
Query: 215 LKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGG 274
K+ T +N + ++ + L+ + K ++ +DT + G
Sbjct: 230 AKR-------TTKNLEAGVMKEMSNSKELT---LRIHSKNFH---EDTL----SSTKAKG 272
Query: 275 ELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSA 334
R REKKA + + IV+G FI+CWLPFF+ L + T ++
Sbjct: 273 HNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKV 332
Query: 335 TTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
WLGY NS LNP+IY + EF++AF++IL C
Sbjct: 333 VFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGC 365
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 191 bits (486), Expect = 7e-49
Identities = 122/339 (35%), Positives = 179/339 (52%), Gaps = 38/339 (11%)
Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
+ L + GN LV ++V + L+ +NYL+VSLA+ADL VA VMP+V ++ GG W F
Sbjct: 91 ITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF 150
Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
C+VF+ +DVM CTASI+ LC ISIDRY + P+ Y + + + +A MI +VW
Sbjct: 151 GHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY---PVRQNGKCMAKMILSVW 207
Query: 159 VLAFAVSCPLLFGF-NTTGDPTVCSISNP-DFVIYSSVVSFYLPFGVTVLVYARIYVVLK 216
+L+ +++ P LFG+ D VC IS + IYS+ V+FY+P V + +Y +IY +
Sbjct: 208 LLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR 267
Query: 217 QRRRKRILTRQNSQCNSVRPGFPQQTLSPDP-----AHLELKRYYSICQDTALGGPGFQE 271
+ K PGFP+ + PD ++L++ C + +
Sbjct: 268 KSAAKHKF-----------PGFPR--VEPDSVIALNGIVKLQKEVEECANLS-------- 306
Query: 272 RGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTH-CQT-CHVSP 329
L + E+ S+ RE+KA + I++GAF VCWLPFFL C T C P
Sbjct: 307 ---RLLKHERKNISIFK-REQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIP 362
Query: 330 ELYSAT-TWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
T WLGY NS +NP IY FN + R + +L C
Sbjct: 363 LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQC 401
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 191 bits (486), Expect = 7e-49
Identities = 122/339 (35%), Positives = 179/339 (52%), Gaps = 38/339 (11%)
Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
+ L + GN LV ++V + L+ +NYL+VSLA+ADL VA VMP+V ++ GG W F
Sbjct: 91 ITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF 150
Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
C+VF+ +DVM CTASI+ LC ISIDRY + P+ Y + + + +A MI +VW
Sbjct: 151 GHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY---PVRQNGKCMAKMILSVW 207
Query: 159 VLAFAVSCPLLFGF-NTTGDPTVCSISNP-DFVIYSSVVSFYLPFGVTVLVYARIYVVLK 216
+L+ +++ P LFG+ D VC IS + IYS+ V+FY+P V + +Y +IY +
Sbjct: 208 LLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR 267
Query: 217 QRRRKRILTRQNSQCNSVRPGFPQQTLSPDP-----AHLELKRYYSICQDTALGGPGFQE 271
+ K PGFP+ + PD ++L++ C + +
Sbjct: 268 KSAAKHKF-----------PGFPR--VEPDSVIALNGIVKLQKEVEECANLS-------- 306
Query: 272 RGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTH-CQT-CHVSP 329
L + E+ S+ RE+KA + I++GAF VCWLPFFL C T C P
Sbjct: 307 ---RLLKHERKNISIFK-REQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIP 362
Query: 330 ELYSAT-TWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
T WLGY NS +NP IY FN + R + +L C
Sbjct: 363 LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQC 401
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 191 bits (486), Expect = 7e-49
Identities = 122/339 (35%), Positives = 179/339 (52%), Gaps = 38/339 (11%)
Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
+ L + GN LV ++V + L+ +NYL+VSLA+ADL VA VMP+V ++ GG W F
Sbjct: 91 ITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF 150
Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
C+VF+ +DVM CTASI+ LC ISIDRY + P+ Y + + + +A MI +VW
Sbjct: 151 GHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY---PVRQNGKCMAKMILSVW 207
Query: 159 VLAFAVSCPLLFGF-NTTGDPTVCSISNP-DFVIYSSVVSFYLPFGVTVLVYARIYVVLK 216
+L+ +++ P LFG+ D VC IS + IYS+ V+FY+P V + +Y +IY +
Sbjct: 208 LLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR 267
Query: 217 QRRRKRILTRQNSQCNSVRPGFPQQTLSPDP-----AHLELKRYYSICQDTALGGPGFQE 271
+ K PGFP+ + PD ++L++ C + +
Sbjct: 268 KSAAKHKF-----------PGFPR--VEPDSVIALNGIVKLQKEVEECANLS-------- 306
Query: 272 RGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTH-CQT-CHVSP 329
L + E+ S+ RE+KA + I++GAF VCWLPFFL C T C P
Sbjct: 307 ---RLLKHERKNISIFK-REQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIP 362
Query: 330 ELYSAT-TWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
T WLGY NS +NP IY FN + R + +L C
Sbjct: 363 LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQC 401
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 191 bits (484), Expect = 1e-48
Identities = 125/343 (36%), Positives = 186/343 (54%), Gaps = 33/343 (9%)
Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
+ LA N V V + R L T NYL+ SLAV DLLV+ LVMP VTG W
Sbjct: 59 ITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGR-WTL 117
Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
++ CD +++ D+ CTASIL+LC I++DRY A+ V Y + + + +R A+MI VW
Sbjct: 118 GQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEY---SAKRTPKRAAVMIALVW 174
Query: 159 VLAFAVSCPLLFGFNTTGDPTVCS-ISNPD---FVIYSSVVSFYLPFGVTVLVYARIYV- 213
V + ++S P F + V + N D + +YS+V +FY P + + +Y RIYV
Sbjct: 175 VFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVE 234
Query: 214 ----VLKQ--RRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP 267
+LKQ R + LTR +Q + PG S + R + ++ G P
Sbjct: 235 ARSRILKQTPNRTGKRLTR--AQLITDSPGSTSSVTSIN------SRVPDVPSES--GSP 284
Query: 268 GF----QERGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQ 323
+ + R + E+K LM RE+KAT+ + I+LGAFIVCWLPFF+ ++ C+
Sbjct: 285 VYVNQVKVRVSDALLEKK---KLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICK 341
Query: 324 -TCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 365
C ++ TWLGY+NS +NP+IYT N +F++AF K++
Sbjct: 342 DACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLI 384
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 190 bits (483), Expect = 2e-48
Identities = 115/343 (33%), Positives = 182/343 (53%), Gaps = 13/343 (3%)
Query: 33 ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPW-VVYLEV 91
+L+ L L N LV A++ R L NYL+ SLAV D LVA LVMP+ +VY +
Sbjct: 27 SLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVY--I 84
Query: 92 TGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVA 151
W ++ CD+++++D+ CT SIL+L AI++DRY A+ V Y + + +
Sbjct: 85 VRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYAR---KRTPKHAG 141
Query: 152 LMITAVWVLAFAVSCPLLFGFNT-TGDPTVCSISNPDFV--IYSSVVSFYLPFGVTVLVY 208
+MIT VW+++ +S P LF + T C I + V IYS+ +FY+P + +++Y
Sbjct: 142 IMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILY 201
Query: 209 ARIYVVLKQRRRKRILTR---QNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALG 265
+IY K KR +R + + + T S +++ K D
Sbjct: 202 YKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKI 261
Query: 266 GPGFQERGGELKREEK-TRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQT 324
+ E K E+ R + RE+KA + ++LGAF++CWLPFF+ ++ C
Sbjct: 262 HSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDK 321
Query: 325 CHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
C +S E+ + WLGY+NS +NP+IYT FN +F+KAF K++ C
Sbjct: 322 CKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRC 364
>gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]
Length = 462
Score = 189 bits (481), Expect = 3e-48
Identities = 142/427 (33%), Positives = 199/427 (46%), Gaps = 81/427 (18%)
Query: 16 GAENSTGASQARPHAYYALSYCA--------LILAIVFGNGLVCMAVLKERALQTTTNYL 67
G N++GAS P Y+ A LI+ V GN LV +AVL RAL+ N
Sbjct: 30 GVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLF 89
Query: 68 VVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISID 127
+VSLA AD+LVATLVMP+ + E+ W F ++ C V++ LDV+ CT+SI++LCAIS+D
Sbjct: 90 LVSLASADILVATLVMPFSLANELMA-YWYFGQVWCGVYLALDVLFCTSSIVHLCAISLD 148
Query: 128 RYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV---CSIS 184
RY +V V Y + + RRV I AVW+++ +S P L D C ++
Sbjct: 149 RYWSVTQAVEYNL---KRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLN 205
Query: 185 NPDFVIYSSVV-SFYLPFGVTVLVYARIYVVLKQRRR----KRILTRQNSQCNSVRPGFP 239
+ + I SS + SF+ P + LVYARIY V K R R KR + + G
Sbjct: 206 DETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLG 265
Query: 240 QQT-------LSPDPAHLELKRYYSICQ-------------------------DTALGGP 267
+P PA +E + + D GP
Sbjct: 266 AAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGP 325
Query: 268 GFQER-----------GGELKREEK-----------------TRNSLMPLREKKATQMVA 299
G E GG L R R + REK+ T ++A
Sbjct: 326 GAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLA 385
Query: 300 IVLGAFIVCWLPFFLTHVLNTHC-QTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFR 358
+V+G F++CW PFF ++ L C + C V L+ W+GY NS+LNPVIYT FN +FR
Sbjct: 386 VVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFR 445
Query: 359 KAFLKIL 365
++F IL
Sbjct: 446 RSFKHIL 452
>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
Length = 465
Score = 183 bits (465), Expect = 2e-46
Identities = 144/450 (32%), Positives = 207/450 (46%), Gaps = 94/450 (20%)
Query: 1 MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCA-----LILAIVFGNGLVCMAVL 55
M SL +G+ ++ G E G ++A P++ L+L VFGN LV +AV
Sbjct: 16 MGSLQPDAGNASWN-GTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVF 74
Query: 56 KERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCT 115
RAL+ N +VSLA AD+LVATLV+P+ + EV G W F + C++++ LDV+ CT
Sbjct: 75 TSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMG-YWYFGKAWCEIYLALDVLFCT 133
Query: 116 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT 175
+SI++LCAIS+DRY ++ + Y + + RR+ +I VWV++ +S P L
Sbjct: 134 SSIVHLCAISLDRYWSITQAIEYNL---KRTPRRIKAIIITVWVISAVISFPPLISIEKK 190
Query: 176 G--------DPTVCSISNPD-FVIYSSVVSFYLPFGVTVLVYARIYVVLKQR-------- 218
G +P C I++ +VI S + SF+ P + +LVY RIY + K+R
Sbjct: 191 GGGGGPQPAEPR-CEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRR 249
Query: 219 -------------RRKRILTRQNS-------------QCNSVRPGFPQQTLSPDPAHLEL 252
RR L + S Q N PG P D L+L
Sbjct: 250 GPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGA-PGEPAPAGPRDTDALDL 308
Query: 253 KRYYSICQDTALGGPGFQERG----GELKREEKTRNSLMPLREKKATQM----------- 297
+ S GP ERG G+ + + +P R AT +
Sbjct: 309 EESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEER 368
Query: 298 ----------------------VAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSAT 335
+A+V+G F+VCW PFF T+ L C V L+
Sbjct: 369 VGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLT--AVGCSVPRTLFKFF 426
Query: 336 TWLGYVNSALNPVIYTTFNIEFRKAFLKIL 365
W GY NS+LNPVIYT FN +FR+AF KIL
Sbjct: 427 FWFGYCNSSLNPVIYTIFNHDFRRAFKKIL 456
>gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
sapiens]
Length = 458
Score = 181 bits (460), Expect = 7e-46
Identities = 113/344 (32%), Positives = 191/344 (55%), Gaps = 24/344 (6%)
Query: 33 ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVT 92
ALS +I+ + GN LV MAV E+ L TNY ++SLA+AD+LV LVMP + +
Sbjct: 57 ALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILY 116
Query: 93 GGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVAL 152
VW R C V+++LDV+ TASI++LCAIS+DRY A+ P+ + ++ + +
Sbjct: 117 DYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRT---KAIM 173
Query: 153 MITAVWVLAFAVSCPL-LFGFNTTG----DPTVCSISNPDFVIYSSVVSFYLPFGVTVLV 207
I VW ++ VS P+ + G + T C +++P+FV+ S V+F++P + V+
Sbjct: 174 KIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVIT 233
Query: 208 YARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP 267
Y VL RR+ +L +++ PG LS D L+ + + ++ +
Sbjct: 234 YCLTIYVL--RRQALMLLHGHTE---EPPG-----LSLD--FLKCCKRNTAEEENSANPN 281
Query: 268 GFQERGGELKREEKTRNSLMPL-REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQ-TC 325
Q K+E + R ++ + E+KA++++ IV F++ W PFF+T++L+ C+ +C
Sbjct: 282 QDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSC 341
Query: 326 H--VSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
+ + +L + W+GYV S +NP++YT FN +R+AF L C
Sbjct: 342 NQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRC 385
>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
Length = 365
Score = 179 bits (454), Expect = 3e-45
Identities = 115/342 (33%), Positives = 183/342 (53%), Gaps = 41/342 (11%)
Query: 47 NGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPW-VVYLEVTGGVWNFSRICCDV 105
N V MA+ + L NYL+ SLAV DLLVA LVMP ++Y+ + W C+V
Sbjct: 40 NLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDR--WKLGYFLCEV 97
Query: 106 FVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVS 165
++++D+ CT SIL+LC I++DRY A+ + Y + + +R ALMI VW ++ +S
Sbjct: 98 WLSVDMTCCTCSILHLCVIALDRYWAITNAIEYAR---KRTAKRAALMILTVWTISIFIS 154
Query: 166 CPLLFGFN---TTGDPTVCSISNPD--FVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRR 220
P LF + + P+ C+I + + IYS++ +FY+P + +++Y RIY K +
Sbjct: 155 MPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQ 214
Query: 221 KRILTR---------QNS--QCNSVRPGFPQQTLSPDPAHLELKRYYSICQ----DTALG 265
KR +R QNS C + + DP E +++++ + D L
Sbjct: 215 KRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPT-TEFEKFHASIRIPPFDNDLD 273
Query: 266 GPGFQERGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTC 325
PG R + RE+KA +++ ++LGAFI+ WLPFF+ ++
Sbjct: 274 HPG-------------ERQQISSTRERKAARILGLILGAFILSWLPFFIKELI-VGLSIY 319
Query: 326 HVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
VS E+ TWLGYVNS +NP++YT+FN +F+ AF K++ C
Sbjct: 320 TVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRC 361
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 177 bits (448), Expect = 2e-44
Identities = 125/377 (33%), Positives = 187/377 (49%), Gaps = 63/377 (16%)
Query: 17 AENSTGASQARPHAYYALSYC---ALILAIVFGNGLVCMAVLKERALQT-TTNYLVVSLA 72
A + TG R + L+ C LIL+ + GN LVC AV++ R L++ TN+ V+SLA
Sbjct: 8 AMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLA 67
Query: 73 VADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAV 132
V+DLLVA LVMPW E+ G W F C +++V D+M TASILNLC IS+DRY A+
Sbjct: 68 VSDLLVAVLVMPWKAVAEIAG-FWPFGSFC-NIWVAFDIMCSTASILNLCVISVDRYWAI 125
Query: 133 VMPVHYQHGTGQSSCRRVALMITAVWVLAFAVS-CPLLFGFN-------TTGDPTVC--S 182
P Y+ + + + ++I+ W L+ +S P+ ++ + G+ T +
Sbjct: 126 SSPFRYER---KMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAET 182
Query: 183 ISNPD------FVIYSSVVSFYLPFGVTVLVYARIY-VVLKQRRRKRILTRQNSQCNSVR 235
I N D + I SSV+SFY+P + ++ Y RIY + KQ RR L R +
Sbjct: 183 IDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN-- 240
Query: 236 PGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLMPLREKKAT 295
CQ T G + E + E + RE K
Sbjct: 241 -----------------------CQTTTGNG-----KPVECSQPESSFKMSFK-RETKVL 271
Query: 296 QMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATT-----WLGYVNSALNPVIY 350
+ +++++G F+ CWLPFF+ + + C + P + T W G+ NS+LNP+IY
Sbjct: 272 KTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIY 331
Query: 351 TTFNIEFRKAFLKILSC 367
FN +FRKAF +L C
Sbjct: 332 -AFNADFRKAFSTLLGC 347
>gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo
sapiens]
Length = 471
Score = 172 bits (435), Expect = 6e-43
Identities = 117/383 (30%), Positives = 194/383 (50%), Gaps = 48/383 (12%)
Query: 8 SGHLNYTCGAENSTGAS-------------QARPHAYYALSYCALILAIVFGNGLVCMAV 54
S N+T +EN T S + + AL +I+ + GN LV MAV
Sbjct: 40 SDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAV 99
Query: 55 LKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMC 114
E+ LQ TNY ++SLA+AD+L+ LVMP + + G W C V++ LDV+
Sbjct: 100 SLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFS 159
Query: 115 TASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPL-LFGFN 173
TASI++LCAIS+DRY A+ P+H+ ++ + L I AVW ++ +S P+ +FG
Sbjct: 160 TASIMHLCAISLDRYVAIQNPIHHSRFNSRT---KAFLKIIAVWTISVGISMPIPVFGLQ 216
Query: 174 TTG---DPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQ 230
C +++ +FV+ S VSF++P + V+ Y ++ +K +++ L +
Sbjct: 217 DDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITY---FLTIKSLQKEATLCVSDLG 273
Query: 231 CNSVRPGF---PQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLM 287
+ F PQ +LS + + Q + PG +T S+
Sbjct: 274 TRAKLASFSFLPQSSLSSE----------KLFQRSIHREPGSY-------TGRRTMQSIS 316
Query: 288 PLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHC-QTCH--VSPELYSATTWLGYVNSA 344
E+KA +++ IV F+V W PFF+T+++ C ++C+ V L + W+GY++SA
Sbjct: 317 --NEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSA 374
Query: 345 LNPVIYTTFNIEFRKAFLKILSC 367
+NP++YT FN +R AF + + C
Sbjct: 375 VNPLVYTLFNKTYRSAFSRYIQC 397
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 170 bits (431), Expect = 2e-42
Identities = 115/340 (33%), Positives = 176/340 (51%), Gaps = 25/340 (7%)
Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
++L IV GN LV +A+ K LQT TN ++SLA ADL++ LV+P+ + V G W +
Sbjct: 68 IVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATI-VVWGRWEY 126
Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
C+++ ++DV+ TASI LC I++DRY A+ P YQ ++ R ++ VW
Sbjct: 127 GSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARG---LVCTVW 183
Query: 159 VLAFAVS-CPLLFGF---------NTTGDPTVCS-ISNPDFVIYSSVVSFYLPFGVTVLV 207
++ VS P+L + DP C ++N + I SSVVSFY+P + V
Sbjct: 184 AISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFV 243
Query: 208 YARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP 267
Y R++ +++ +K + RP P + P PA + TA P
Sbjct: 244 YLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATA---P 300
Query: 268 GFQERGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV 327
R G ++ + L+ LRE+KA + + I++G F +CWLPFFL +V+ + V
Sbjct: 301 LANGRAG-----KRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHREL-V 354
Query: 328 SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
L+ WLGY NSA NP+IY + +FRKAF +L C
Sbjct: 355 PDRLFVFFNWLGYANSAFNPIIYCR-SPDFRKAFQGLLCC 393
>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
Length = 357
Score = 168 bits (426), Expect = 6e-42
Identities = 109/332 (32%), Positives = 170/332 (51%), Gaps = 31/332 (9%)
Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
L+ A N LV +L+ R + LV S+AV+D+LVA LVMP + E++G W
Sbjct: 50 LVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQL 109
Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
R C +++ DV+ CTASI N+ AI++DRY ++ + Y T + +MI W
Sbjct: 110 GRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSN---VMIALTW 166
Query: 159 VLAFAVS-CPLLFGFNTT--GDPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVV 214
L+ +S PLLFG+ T C +S P + ++S+V +FYLP V + VY +IY
Sbjct: 167 ALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKA 226
Query: 215 LKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGG 274
K R+ +R+ + + + + + P + R+ ++ FQ G
Sbjct: 227 AK----FRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVT---------FQPE-G 272
Query: 275 ELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSA 334
+ RE+K E++A MV I++G F++CW+PFFLT +++ C +C + S
Sbjct: 273 DTWREQK---------EQRAALMVGILIGVFVLCWIPFFLTELISPLC-SCDIPAIWKSI 322
Query: 335 TTWLGYVNSALNPVIYTTFNIEFRKAFLKILS 366
WLGY NS NP+IYT FN + AF S
Sbjct: 323 FLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFS 354
>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
Length = 408
Score = 167 bits (424), Expect = 1e-41
Identities = 121/338 (35%), Positives = 173/338 (51%), Gaps = 37/338 (10%)
Query: 40 ILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFS 99
+LA V GN LV +A+ LQT TN V SLA ADL++ LV+P L +TG W
Sbjct: 48 VLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGH-WPLG 106
Query: 100 RICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWV 159
C+++ ++DV+ TASI LCA+++DRY AV P+ Y C R A+++ VWV
Sbjct: 107 ATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYG-ALVTKRCARTAVVL--VWV 163
Query: 160 LAFAVS-CPLLFGFNTTG----------DPTVCSI-SNPDFVIYSSVVSFYLPFGVTVLV 207
++ AVS P++ + G +P C+ SN +V+ SS VSFYLP V + V
Sbjct: 164 VSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFV 223
Query: 208 YARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP 267
YAR++VV R+ R+L + + FP + P P+ C G P
Sbjct: 224 YARVFVVAT--RQLRLLRGELGR-------FPPEESPPAPSRSLAPAPVGTCAPPE-GVP 273
Query: 268 GFQERGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV 327
R L +PLRE +A + +++G F +CWLPFFL +VL V
Sbjct: 274 ACGRRPARL----------LPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLV 323
Query: 328 SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 365
+ A WLGY NSA NP+IY + +FR AF ++L
Sbjct: 324 PGPAFLALNWLGYANSAFNPLIYCR-SPDFRSAFRRLL 360
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 166 bits (421), Expect = 2e-41
Identities = 114/348 (32%), Positives = 178/348 (51%), Gaps = 66/348 (18%)
Query: 39 LILAIVFGNGLVCMAVLKERALQTT-TNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWN 97
+IL + GN LV +AV +R L+ TNY +VSLA ADLLV+ LVMP+ +E+ +W
Sbjct: 29 VILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGA-IELVQDIWI 87
Query: 98 FSRICCDVFVTLDVMMCTASILNLCAISIDRYTAV-VMPVHYQHGTGQSSCRRVALMITA 156
+ + C V +LDV++ TASI +LC IS+DRY A+ P+ Y++ + + R+ALM+
Sbjct: 88 YGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRN---KMTPLRIALMLGG 144
Query: 157 VWVLAFAVS-CPLLFGFNTTG--------------DPTVC-SISNPDFVIYSSVVSFYLP 200
WV+ +S P++ G+N G + T C + N + I SVV+FY+P
Sbjct: 145 CWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIP 204
Query: 201 FGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQ 260
F + VL Y RIYV K+ + + ++ + RP
Sbjct: 205 FLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP------------------------ 240
Query: 261 DTALGGPGFQERGGELKREEKTRNSLMPLR-EKKATQMVAIVLGAFIVCWLPFFLTHVLN 319
+ ++S +R E KA + + I++G F +CW PFF+T++++
Sbjct: 241 ------------------QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVD 282
Query: 320 THCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
V ++++A WLGY+NS LNP +Y N FR+AFL IL C
Sbjct: 283 PFIDYT-VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCC 329
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 166 bits (421), Expect = 2e-41
Identities = 114/348 (32%), Positives = 178/348 (51%), Gaps = 66/348 (18%)
Query: 39 LILAIVFGNGLVCMAVLKERALQTT-TNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWN 97
+IL + GN LV +AV +R L+ TNY +VSLA ADLLV+ LVMP+ +E+ +W
Sbjct: 29 VILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGA-IELVQDIWI 87
Query: 98 FSRICCDVFVTLDVMMCTASILNLCAISIDRYTAV-VMPVHYQHGTGQSSCRRVALMITA 156
+ + C V +LDV++ TASI +LC IS+DRY A+ P+ Y++ + + R+ALM+
Sbjct: 88 YGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRN---KMTPLRIALMLGG 144
Query: 157 VWVLAFAVS-CPLLFGFNTTG--------------DPTVC-SISNPDFVIYSSVVSFYLP 200
WV+ +S P++ G+N G + T C + N + I SVV+FY+P
Sbjct: 145 CWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIP 204
Query: 201 FGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQ 260
F + VL Y RIYV K+ + + ++ + RP
Sbjct: 205 FLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP------------------------ 240
Query: 261 DTALGGPGFQERGGELKREEKTRNSLMPLR-EKKATQMVAIVLGAFIVCWLPFFLTHVLN 319
+ ++S +R E KA + + I++G F +CW PFF+T++++
Sbjct: 241 ------------------QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVD 282
Query: 320 THCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
V ++++A WLGY+NS LNP +Y N FR+AFL IL C
Sbjct: 283 PFIDYT-VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCC 329
>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
Length = 360
Score = 166 bits (421), Expect = 2e-41
Identities = 114/348 (32%), Positives = 178/348 (51%), Gaps = 66/348 (18%)
Query: 39 LILAIVFGNGLVCMAVLKERALQTT-TNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWN 97
+IL + GN LV +AV +R L+ TNY +VSLA ADLLV+ LVMP+ +E+ +W
Sbjct: 29 VILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGA-IELVQDIWI 87
Query: 98 FSRICCDVFVTLDVMMCTASILNLCAISIDRYTAV-VMPVHYQHGTGQSSCRRVALMITA 156
+ + C V +LDV++ TASI +LC IS+DRY A+ P+ Y++ + + R+ALM+
Sbjct: 88 YGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRN---KMTPLRIALMLGG 144
Query: 157 VWVLAFAVS-CPLLFGFNTTG--------------DPTVC-SISNPDFVIYSSVVSFYLP 200
WV+ +S P++ G+N G + T C + N + I SVV+FY+P
Sbjct: 145 CWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIP 204
Query: 201 FGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQ 260
F + VL Y RIYV K+ + + ++ + RP
Sbjct: 205 FLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP------------------------ 240
Query: 261 DTALGGPGFQERGGELKREEKTRNSLMPLR-EKKATQMVAIVLGAFIVCWLPFFLTHVLN 319
+ ++S +R E KA + + I++G F +CW PFF+T++++
Sbjct: 241 ------------------QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVD 282
Query: 320 THCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
V ++++A WLGY+NS LNP +Y N FR+AFL IL C
Sbjct: 283 PFIDYT-VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCC 329
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.137 0.430
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,609,585
Number of Sequences: 37866
Number of extensions: 596407
Number of successful extensions: 3513
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 377
Number of HSP's successfully gapped in prelim test: 254
Number of HSP's that attempted gapping in prelim test: 1994
Number of HSP's gapped (non-prelim): 1128
length of query: 367
length of database: 18,247,518
effective HSP length: 104
effective length of query: 263
effective length of database: 14,309,454
effective search space: 3763386402
effective search space used: 3763386402
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.