BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] (400 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 808 0.0 gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 727 0.0 gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] 391 e-109 gi|4503385 dopamine receptor D2 isoform long [Homo sapiens] 384 e-106 gi|32483397 dopamine receptor D4 [Homo sapiens] 256 3e-68 gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 209 3e-54 gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 195 5e-50 gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] 194 1e-49 gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 192 3e-49 gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens] 191 8e-49 gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens] 191 8e-49 gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 188 6e-48 gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 188 6e-48 gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 188 6e-48 gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 188 6e-48 gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 187 1e-47 gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 184 2e-46 gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 184 2e-46 gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 184 2e-46 gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 182 4e-46 gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 181 8e-46 gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap... 171 8e-43 gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 166 3e-41 gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 165 8e-41 gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 155 5e-38 gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 155 5e-38 gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo s... 154 2e-37 gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 147 2e-35 gi|194018562 histamine receptor H3 [Homo sapiens] 137 2e-32 gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens] 137 2e-32 >gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] Length = 400 Score = 808 bits (2086), Expect = 0.0 Identities = 400/400 (100%), Positives = 400/400 (100%) Query: 1 MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL 60 MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL Sbjct: 1 MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL 60 Query: 61 QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN 120 QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN Sbjct: 61 QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN 120 Query: 121 LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV 180 LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV Sbjct: 121 LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV 180 Query: 181 CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ 240 CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ Sbjct: 181 CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ 240 Query: 241 QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK 300 QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK Sbjct: 241 QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK 300 Query: 301 LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV 360 LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV Sbjct: 301 LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV 360 Query: 361 SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400 SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC Sbjct: 361 SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400 >gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] Length = 367 Score = 727 bits (1877), Expect = 0.0 Identities = 366/400 (91%), Positives = 367/400 (91%), Gaps = 33/400 (8%) Query: 1 MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL 60 MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL Sbjct: 1 MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL 60 Query: 61 QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN 120 QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN Sbjct: 61 QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN 120 Query: 121 LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV 180 LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV Sbjct: 121 LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV 180 Query: 181 CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ 240 CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ Sbjct: 181 CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ 240 Query: 241 QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK 300 QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSL Sbjct: 241 QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSL-------------- 286 Query: 301 LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV 360 +PLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV Sbjct: 287 -------------------MPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV 327 Query: 361 SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400 SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC Sbjct: 328 SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367 >gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] Length = 414 Score = 391 bits (1004), Expect = e-109 Identities = 221/399 (55%), Positives = 268/399 (67%), Gaps = 24/399 (6%) Query: 19 NSTGASQARPHA-YYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLL 77 N + RPH YYA LI IVFGN LVCMAV +E+ALQTTTNYL+VSLAVADLL Sbjct: 23 NGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLL 82 Query: 78 VATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVH 137 VATLVMPWVVYLEV G W FSRI CD+FVTLDVMMCTASILNLCAISIDRYTAV MP+ Sbjct: 83 VATLVMPWVVYLEVV-GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPML 141 Query: 138 YQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSF 197 Y T SS RRV +MI+ VWVL+F +SCPLLFG N D C I+NP FV+YSS+VSF Sbjct: 142 Y--NTRYSSKRRVTVMISIVWVLSFTISCPLLFGLN-NADQNECIIANPAFVVYSSIVSF 198 Query: 198 YLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYS 257 Y+PF VT+LVY +IY+VL+ RRRKR+ T+++S+ P + + LE++ S Sbjct: 199 YVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSS 257 Query: 258 ICQDTALGGPGFQERGGELKREEKTRNSLSPT--------------IAPKLS--LEVRKL 301 +L + + + L T PK++ E++ + Sbjct: 258 TSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTM 317 Query: 302 SNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVS 361 NG+ TSLK + +EKKATQM+AIVLG FI+CWLPFF+TH+LN HC C++ Sbjct: 318 PNGKTRTSLKTMSRRKLS-QQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIP 375 Query: 362 PELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400 P LYSA TWLGYVNSA+NP+IYTTFNIEFRKAFLKIL C Sbjct: 376 PVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 414 >gi|4503385 dopamine receptor D2 isoform long [Homo sapiens] Length = 443 Score = 384 bits (985), Expect = e-106 Identities = 228/434 (52%), Positives = 272/434 (62%), Gaps = 65/434 (14%) Query: 19 NSTGASQARPHA-YYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLL 77 N + RPH YYA LI IVFGN LVCMAV +E+ALQTTTNYL+VSLAVADLL Sbjct: 23 NGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLL 82 Query: 78 VATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVH 137 VATLVMPWVVYLEV G W FSRI CD+FVTLDVMMCTASILNLCAISIDRYTAV MP+ Sbjct: 83 VATLVMPWVVYLEVV-GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPML 141 Query: 138 YQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSF 197 Y T SS RRV +MI+ VWVL+F +SCPLLFG N D C I+NP FV+YSS+VSF Sbjct: 142 Y--NTRYSSKRRVTVMISIVWVLSFTISCPLLFGLN-NADQNECIIANPAFVVYSSIVSF 198 Query: 198 YLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYS 257 Y+PF VT+LVY +IY+VL+ RRRKR+ T+++S+ P + P ++L Sbjct: 199 YVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKL----- 252 Query: 258 ICQDTALGGPGF---------QERGGELKRE--------EKTRNSLSPTIAPKLSL---- 296 C F R EL+ E E+TR S P +L+L Sbjct: 253 -CTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPS 311 Query: 297 ------------------------------EVRKLSNGRLSTSLKLGPLQPRGVPLREKK 326 E++ + NG+ TSLK + +EKK Sbjct: 312 HHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLS-QQKEKK 370 Query: 327 ATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTF 386 ATQM+AIVLG FI+CWLPFF+TH+LN HC C++ P LYSA TWLGYVNSA+NP+IYTTF Sbjct: 371 ATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIPPVLYSAFTWLGYVNSAVNPIIYTTF 429 Query: 387 NIEFRKAFLKILSC 400 NIEFRKAFLKIL C Sbjct: 430 NIEFRKAFLKILHC 443 >gi|32483397 dopamine receptor D4 [Homo sapiens] Length = 419 Score = 256 bits (653), Expect = 3e-68 Identities = 160/415 (38%), Positives = 212/415 (51%), Gaps = 52/415 (12%) Query: 16 GAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVAD 75 GA A A A + LI A++ GN LVC++V ERALQT TN +VSLA AD Sbjct: 21 GASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAAD 80 Query: 76 LLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMP 135 LL+A LV+P VY EV GG W S CD + +DVM+CTASI NLCAIS+DR+ AV +P Sbjct: 81 LLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVP 140 Query: 136 VHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT--GDPTVCSISNPDFVIYSS 193 + Y Q RR L+I A W+L+ AV+ P+L G N DP VC + + D+V+YSS Sbjct: 141 LRYNR---QGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSS 197 Query: 194 VVSFYLPFGVTVLVYARIYVVLKQ---RRRKRILTRQ----------------------- 227 V SF+LP + +L+Y + L++ RR ++ R Sbjct: 198 VCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDP 257 Query: 228 -NSQCNSVRPGFPQQTLSPDPAHLELKRYYSIC-QDTALGGPGF--QERGGELKREEKTR 283 C PG P+ PD A C D A PG G + R Sbjct: 258 CGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVR 317 Query: 284 NSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWL 343 + P P+ + R+ +++ RE+KA +++ +V+GAF++CW Sbjct: 318 AAALP---PQTPPQTRRRRRAKITG--------------RERKAMRVLPVVVGAFLLCWT 360 Query: 344 PFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 398 PFF+ H+ C C V P L SA TWLGYVNSALNPVIYT FN EFR F K L Sbjct: 361 PFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKAL 415 >gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sapiens] Length = 422 Score = 209 bits (533), Expect = 3e-54 Identities = 134/411 (32%), Positives = 205/411 (49%), Gaps = 46/411 (11%) Query: 19 NSTGASQARP--HAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADL 76 N+TG S +L LI V GN V A+ ER+LQ NYL+ SLAV DL Sbjct: 24 NTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDL 83 Query: 77 LVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPV 136 +V+ LV+P +V W ++ CD+F+ LDV+ CT+SIL+LCAI++DRY A+ P+ Sbjct: 84 MVSVLVLPMAALYQVLNK-WTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPI 142 Query: 137 HYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNT---TGDPTVCSIS-NPDFVIYS 192 Y + + RR A +I+ W++ F +S P + G+ T DP C+IS + + IYS Sbjct: 143 DY---VNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYS 199 Query: 193 SVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAH--- 249 + +FY+P + +++Y RI+ + R RK + + + ++ P +P P Sbjct: 200 TFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASP----APQPKKSVN 255 Query: 250 -----------LELKRYYSICQDTAL--GGPGFQ------ERGGELKREEKTRNSLSPTI 290 +E K ++C + A+ G G R G K + PT Sbjct: 256 GESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTP 315 Query: 291 APKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHV 350 S E + N + L RE+K + + I++G FI+CWLPFF+ + Sbjct: 316 CAPASFERKNERNAEAKRKMALA---------RERKTVKTLGIIMGTFILCWLPFFIVAL 366 Query: 351 LNTHCQ-TCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400 + C+ +CH+ L + WLGY NS LNPVIY FN +F+ AF KI+ C Sbjct: 367 VLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKC 417 >gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sapiens] Length = 377 Score = 195 bits (496), Expect = 5e-50 Identities = 127/373 (34%), Positives = 189/373 (50%), Gaps = 50/373 (13%) Query: 33 ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVT 92 A+ + LA V N V +L R L T NYL+ SLA DLLV+ LVMP + +T Sbjct: 42 AVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTIT 101 Query: 93 GGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVAL 152 WNF +I CD++++ D+ CTASIL+LC I++DRY A+ + Y + + + A Sbjct: 102 H-TWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEY---SKRRTAGHAAT 157 Query: 153 MITAVWVLAFAVSCPLLFGFNTTG----DPTVCSISNPDFVIYSSVVSFYLPFGVTVLVY 208 MI VW ++ +S P LF + + S + IYS+ +FY+P + +++Y Sbjct: 158 MIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILY 217 Query: 209 ARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPG 268 RIY + R RIL +P L KR+ + T G Sbjct: 218 GRIY----RAARNRIL---------------------NPPSLYGKRFTTAHLITGSAGSS 252 Query: 269 FQERGGELKREEKTRNSLSPTI--APKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKK 326 L E + ++ SP K+ L L R+S + RE+K Sbjct: 253 LCSLNSSL-HEGHSHSAGSPLFFNHVKIKLADSALERKRISAA-------------RERK 298 Query: 327 ATQMVAIVLGAFIVCWLPFFLTHVLNTHCQ-TCHVSPELYSATTWLGYVNSALNPVIYTT 385 AT+++ I+LGAFI+CWLPFF+ ++ C+ +C + P L+ TWLGY+NS +NP+IYT Sbjct: 299 ATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTV 358 Query: 386 FNIEFRKAFLKIL 398 FN EFR+AF KI+ Sbjct: 359 FNEEFRQAFQKIV 371 >gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] Length = 465 Score = 194 bits (493), Expect = 1e-49 Identities = 153/456 (33%), Positives = 219/456 (48%), Gaps = 73/456 (16%) Query: 1 MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCA-----LILAIVFGNGLVCMAVL 55 M SL +G+ ++ G E G ++A P++ L+L VFGN LV +AV Sbjct: 16 MGSLQPDAGNASWN-GTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVF 74 Query: 56 KERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCT 115 RAL+ N +VSLA AD+LVATLV+P+ + EV G W F + C++++ LDV+ CT Sbjct: 75 TSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMG-YWYFGKAWCEIYLALDVLFCT 133 Query: 116 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT 175 +SI++LCAIS+DRY ++ + Y + + RR+ +I VWV++ +S P L Sbjct: 134 SSIVHLCAISLDRYWSITQAIEYNL---KRTPRRIKAIIITVWVISAVISFPPLISIEKK 190 Query: 176 G--------DPTVCSISNPD-FVIYSSVVSFYLPFGVTVLVYARIYVVLKQR-------- 218 G +P C I++ +VI S + SF+ P + +LVY RIY + K+R Sbjct: 191 GGGGGPQPAEPR-CEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRR 249 Query: 219 -------------RRKRILTRQNS-------------QCNSVRPGFPQQTLSPDPAHLEL 252 RR L + S Q N PG P D L+L Sbjct: 250 GPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGA-PGEPAPAGPRDTDALDL 308 Query: 253 KRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKL 312 + S GP ERG K + + + + P SL R + T Sbjct: 309 EESSSSDHAERPPGPRRPERGPRGKGKAR-----ASQVKPGDSLPRRGPGATGIGTP-AA 362 Query: 313 GPLQP----------RGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSP 362 GP + RG REK+ T ++A+V+G F+VCW PFF T+ L C V Sbjct: 363 GPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLT--AVGCSVPR 420 Query: 363 ELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 398 L+ W GY NS+LNPVIYT FN +FR+AF KIL Sbjct: 421 TLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL 456 >gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] Length = 572 Score = 192 bits (489), Expect = 3e-49 Identities = 127/366 (34%), Positives = 181/366 (49%), Gaps = 54/366 (14%) Query: 38 ALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWN 97 A IL V GN LV ++V R LQT TNY +V+LAVADLL++ V+P+ +EV G W Sbjct: 105 AFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLG-FWA 163 Query: 98 FSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAV 157 F R CDV+ +DV+ CTASIL+LC IS+DRY V + Y + R+ A ++ + Sbjct: 164 FGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTE---RKAAAILALL 220 Query: 158 WVLAFAVSCPLLFGFN--TTGDPTVCSISNP-DFVIYSSVVSFYLPFGVTVLVYARIYVV 214 WV+A VS L G+ D C I+ + ++SSV SFYLP V V++Y R+YVV Sbjct: 221 WVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVV 280 Query: 215 LKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGG 274 + R S+ G ++ L + C+ A G G Sbjct: 281 ARSTTR------------SLEAGVKRERGKASEVVLRIH-----CRGAATGADG------ 317 Query: 275 ELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIV 334 R++ T LS+ + K S REKKA + +AIV Sbjct: 318 ----AHGMRSAKGHTFRSSLSVRLLKFS--------------------REKKAAKTLAIV 353 Query: 335 LGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAF 394 +G F++CW PFF L + S ++ WLGY NS +NP+IY + EF++AF Sbjct: 354 VGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAF 413 Query: 395 LKILSC 400 L++L C Sbjct: 414 LRLLRC 419 >gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens] Length = 462 Score = 191 bits (486), Expect = 8e-49 Identities = 144/427 (33%), Positives = 207/427 (48%), Gaps = 48/427 (11%) Query: 16 GAENSTGASQARPHAYYALSYCA--------LILAIVFGNGLVCMAVLKERALQTTTNYL 67 G N++GAS P Y+ A LI+ V GN LV +AVL RAL+ N Sbjct: 30 GVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLF 89 Query: 68 VVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISID 127 +VSLA AD+LVATLVMP+ + E+ W F ++ C V++ LDV+ CT+SI++LCAIS+D Sbjct: 90 LVSLASADILVATLVMPFSLANELMA-YWYFGQVWCGVYLALDVLFCTSSIVHLCAISLD 148 Query: 128 RYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV---CSIS 184 RY +V V Y + + RRV I AVW+++ +S P L D C ++ Sbjct: 149 RYWSVTQAVEYNL---KRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLN 205 Query: 185 NPDFVIYSSVV-SFYLPFGVTVLVYARIYVVLKQRRR----KRILTRQNSQCNSVRPGFP 239 + + I SS + SF+ P + LVYARIY V K R R KR + + G Sbjct: 206 DETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLG 265 Query: 240 QQT-------LSPDPAHLELKRYYSICQDT----ALGGPGFQERGGELKREEKTRNSLSP 288 +P PA +E + + AL G + G E P Sbjct: 266 AAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGP 325 Query: 289 TIAPKLSLEVRKL--SNGRLSTS--------------LKLGPLQPRGVPLREKKATQMVA 332 A +L + GRLS + + + + REK+ T ++A Sbjct: 326 GAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLA 385 Query: 333 IVLGAFIVCWLPFFLTHVLNTHC-QTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFR 391 +V+G F++CW PFF ++ L C + C V L+ W+GY NS+LNPVIYT FN +FR Sbjct: 386 VVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFR 445 Query: 392 KAFLKIL 398 ++F IL Sbjct: 446 RSFKHIL 452 >gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens] Length = 450 Score = 191 bits (486), Expect = 8e-49 Identities = 135/433 (31%), Positives = 211/433 (48%), Gaps = 68/433 (15%) Query: 30 AYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYL 89 A A + LIL +FGN LV +AVL R+L+ N +VSLA AD+LVATL++P+ + Sbjct: 13 AAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLAN 72 Query: 90 EVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRR 149 E+ G W F R C+V++ LDV+ CT+SI++LCAIS+DRY AV + Y + + RR Sbjct: 73 ELLG-YWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEY---NSKRTPRR 128 Query: 150 VALMITAVWVLAFAVSCPLLF-----GFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVT 204 + +I VW++A +S P L G G P +++ SS+ SF+ P + Sbjct: 129 IKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIM 188 Query: 205 VLVYARIYVVLKQRRRK---------------------------------RILTRQNSQC 231 +LVY RIY++ K+ R+ + + + Sbjct: 189 ILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNG 248 Query: 232 NSVRPGFPQQTLSP-DPAHLELKRYYSICQDTALG------GPGFQERGGELKREEKTRN 284 +S G ++ +P D L ++ ++ G G ++ E + EE+ Sbjct: 249 HSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEE 308 Query: 285 SLSPTIAP-----KLSLEVRKLSNGRLSTSLKLGPLQPRGVP-------------LREKK 326 P P S +++ R+ +L+ L RGV REK+ Sbjct: 309 ECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKR 368 Query: 327 ATQMVAIVLGAFIVCWLPFFLTHVLNTHC-QTCHVSPELYSATTWLGYVNSALNPVIYTT 385 T ++A+V+G F++CW PFF ++ L C + C V L+ W+GY NS+LNPVIYT Sbjct: 369 FTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTI 428 Query: 386 FNIEFRKAFLKIL 398 FN +FR+AF +IL Sbjct: 429 FNQDFRRAFRRIL 441 >gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] Length = 455 Score = 188 bits (478), Expect = 6e-48 Identities = 121/363 (33%), Positives = 181/363 (49%), Gaps = 60/363 (16%) Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98 LIL V GN LV ++V R L + T+Y +V+LAVADLL+ + V+P+ EV G W F Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAF 94 Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158 R+ C+++ +DV+ CTASI+ LC ISIDRY V P+ Y Q RR + + VW Sbjct: 95 GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ---RRGLMALLCVW 151 Query: 159 VLAFAVSCPLLFGFNTTG--DPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVVL 215 L+ +S LFG+ D T+C I+ P +V++S++ SFYLP + +++Y R+YVV Sbjct: 152 ALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211 Query: 216 KQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGE 275 K+ R ++ G + L + R ++ GG G Sbjct: 212 KRESR------------GLKSGLKTDKSDSEQVTLRIHR-----KNAPAGGSGM------ 248 Query: 276 LKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVL 335 KT+ S+ + K S REKKA + + IV+ Sbjct: 249 --ASAKTKT--------HFSVRLLKFS--------------------REKKAAKTLGIVV 278 Query: 336 GAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFL 395 G F++CWLPFFL + + S ++ WLGY+NS +NP+IY + EF+KAF Sbjct: 279 GCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQ 338 Query: 396 KIL 398 +L Sbjct: 339 NVL 341 >gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] Length = 466 Score = 188 bits (478), Expect = 6e-48 Identities = 121/363 (33%), Positives = 181/363 (49%), Gaps = 60/363 (16%) Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98 LIL V GN LV ++V R L + T+Y +V+LAVADLL+ + V+P+ EV G W F Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAF 94 Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158 R+ C+++ +DV+ CTASI+ LC ISIDRY V P+ Y Q RR + + VW Sbjct: 95 GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ---RRGLMALLCVW 151 Query: 159 VLAFAVSCPLLFGFNTTG--DPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVVL 215 L+ +S LFG+ D T+C I+ P +V++S++ SFYLP + +++Y R+YVV Sbjct: 152 ALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211 Query: 216 KQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGE 275 K+ R ++ G + L + R ++ GG G Sbjct: 212 KRESR------------GLKSGLKTDKSDSEQVTLRIHR-----KNAPAGGSGM------ 248 Query: 276 LKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVL 335 KT+ S+ + K S REKKA + + IV+ Sbjct: 249 --ASAKTKT--------HFSVRLLKFS--------------------REKKAAKTLGIVV 278 Query: 336 GAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFL 395 G F++CWLPFFL + + S ++ WLGY+NS +NP+IY + EF+KAF Sbjct: 279 GCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQ 338 Query: 396 KIL 398 +L Sbjct: 339 NVL 341 >gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] Length = 475 Score = 188 bits (478), Expect = 6e-48 Identities = 121/363 (33%), Positives = 181/363 (49%), Gaps = 60/363 (16%) Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98 LIL V GN LV ++V R L + T+Y +V+LAVADLL+ + V+P+ EV G W F Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAF 94 Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158 R+ C+++ +DV+ CTASI+ LC ISIDRY V P+ Y Q RR + + VW Sbjct: 95 GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ---RRGLMALLCVW 151 Query: 159 VLAFAVSCPLLFGFNTTG--DPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVVL 215 L+ +S LFG+ D T+C I+ P +V++S++ SFYLP + +++Y R+YVV Sbjct: 152 ALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211 Query: 216 KQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGE 275 K+ R ++ G + L + R ++ GG G Sbjct: 212 KRESR------------GLKSGLKTDKSDSEQVTLRIHR-----KNAPAGGSGM------ 248 Query: 276 LKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVL 335 KT+ S+ + K S REKKA + + IV+ Sbjct: 249 --ASAKTKT--------HFSVRLLKFS--------------------REKKAAKTLGIVV 278 Query: 336 GAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFL 395 G F++CWLPFFL + + S ++ WLGY+NS +NP+IY + EF+KAF Sbjct: 279 GCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQ 338 Query: 396 KIL 398 +L Sbjct: 339 NVL 341 >gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] Length = 429 Score = 188 bits (478), Expect = 6e-48 Identities = 121/363 (33%), Positives = 181/363 (49%), Gaps = 60/363 (16%) Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98 LIL V GN LV ++V R L + T+Y +V+LAVADLL+ + V+P+ EV G W F Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAF 94 Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158 R+ C+++ +DV+ CTASI+ LC ISIDRY V P+ Y Q RR + + VW Sbjct: 95 GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ---RRGLMALLCVW 151 Query: 159 VLAFAVSCPLLFGFNTTG--DPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVVL 215 L+ +S LFG+ D T+C I+ P +V++S++ SFYLP + +++Y R+YVV Sbjct: 152 ALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211 Query: 216 KQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGE 275 K+ R ++ G + L + R ++ GG G Sbjct: 212 KRESR------------GLKSGLKTDKSDSEQVTLRIHR-----KNAPAGGSGM------ 248 Query: 276 LKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVL 335 KT+ S+ + K S REKKA + + IV+ Sbjct: 249 --ASAKTKT--------HFSVRLLKFS--------------------REKKAAKTLGIVV 278 Query: 336 GAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFL 395 G F++CWLPFFL + + S ++ WLGY+NS +NP+IY + EF+KAF Sbjct: 279 GCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQ 338 Query: 396 KIL 398 +L Sbjct: 339 NVL 341 >gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] Length = 520 Score = 187 bits (476), Expect = 1e-47 Identities = 125/366 (34%), Positives = 188/366 (51%), Gaps = 57/366 (15%) Query: 38 ALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWN 97 A IL + GN LV ++V R L+T TNY +V+LA+ADLL++ V+P+ LEV G W Sbjct: 54 AFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLG-YWV 112 Query: 98 FSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAV 157 RI CD++ +DV+ CTASIL+LCAISIDRY V + Y + R+ L + +V Sbjct: 113 LGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTR---RKAILALLSV 169 Query: 158 WVLAFAVSCPLLFGFN--TTGDPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVV 214 WVL+ +S L G+ D C ++ P + ++SS+ SFY+P V +++Y R+Y+V Sbjct: 170 WVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIV 229 Query: 215 LKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGG 274 K+ T +N + ++ + L+ + K ++ +DT Sbjct: 230 AKR-------TTKNLEAGVMKEMSNSKELT---LRIHSKNFH---EDT------------ 264 Query: 275 ELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIV 334 LS K N R S ++KL REKKA + + IV Sbjct: 265 -------------------LSSTKAKGHNPRSSIAVKLFKFS------REKKAAKTLGIV 299 Query: 335 LGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAF 394 +G FI+CWLPFF+ L + T ++ WLGY NS LNP+IY + EF++AF Sbjct: 300 VGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAF 359 Query: 395 LKILSC 400 ++IL C Sbjct: 360 VRILGC 365 >gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] Length = 432 Score = 184 bits (466), Expect = 2e-46 Identities = 129/367 (35%), Positives = 181/367 (49%), Gaps = 61/367 (16%) Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98 + L + GN LV ++V + L+ +NYL+VSLA+ADL VA VMP+V ++ GG W F Sbjct: 91 ITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF 150 Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158 C+VF+ +DVM CTASI+ LC ISIDRY + P+ Y + + + +A MI +VW Sbjct: 151 GHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY---PVRQNGKCMAKMILSVW 207 Query: 159 VLAFAVSCPLLFGF-NTTGDPTVCSISNP-DFVIYSSVVSFYLPFGVTVLVYARIYVVLK 216 +L+ +++ P LFG+ D VC IS + IYS+ V+FY+P V + +Y +IY + Sbjct: 208 LLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR 267 Query: 217 QRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGEL 276 + K PGFP+ + PD AL G Sbjct: 268 KSAAKHKF-----------PGFPR--VEPDSV-------------IALNG---------- 291 Query: 277 KREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLG 336 KL EV + +N LS LK + + RE+KA + I++G Sbjct: 292 --------------IVKLQKEVEECAN--LSRLLK-HERKNISIFKREQKAATTLGIIVG 334 Query: 337 AFIVCWLPFFLTHVLNTH-CQT-CHVSPELYSAT-TWLGYVNSALNPVIYTTFNIEFRKA 393 AF VCWLPFFL C T C P T WLGY NS +NP IY FN + R Sbjct: 335 AFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTT 394 Query: 394 FLKILSC 400 + +L C Sbjct: 395 YRSLLQC 401 >gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] Length = 479 Score = 184 bits (466), Expect = 2e-46 Identities = 129/367 (35%), Positives = 181/367 (49%), Gaps = 61/367 (16%) Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98 + L + GN LV ++V + L+ +NYL+VSLA+ADL VA VMP+V ++ GG W F Sbjct: 91 ITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF 150 Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158 C+VF+ +DVM CTASI+ LC ISIDRY + P+ Y + + + +A MI +VW Sbjct: 151 GHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY---PVRQNGKCMAKMILSVW 207 Query: 159 VLAFAVSCPLLFGF-NTTGDPTVCSISNP-DFVIYSSVVSFYLPFGVTVLVYARIYVVLK 216 +L+ +++ P LFG+ D VC IS + IYS+ V+FY+P V + +Y +IY + Sbjct: 208 LLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR 267 Query: 217 QRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGEL 276 + K PGFP+ + PD AL G Sbjct: 268 KSAAKHKF-----------PGFPR--VEPDSV-------------IALNG---------- 291 Query: 277 KREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLG 336 KL EV + +N LS LK + + RE+KA + I++G Sbjct: 292 --------------IVKLQKEVEECAN--LSRLLK-HERKNISIFKREQKAATTLGIIVG 334 Query: 337 AFIVCWLPFFLTHVLNTH-CQT-CHVSPELYSAT-TWLGYVNSALNPVIYTTFNIEFRKA 393 AF VCWLPFFL C T C P T WLGY NS +NP IY FN + R Sbjct: 335 AFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTT 394 Query: 394 FLKILSC 400 + +L C Sbjct: 395 YRSLLQC 401 >gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] Length = 445 Score = 184 bits (466), Expect = 2e-46 Identities = 129/367 (35%), Positives = 181/367 (49%), Gaps = 61/367 (16%) Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98 + L + GN LV ++V + L+ +NYL+VSLA+ADL VA VMP+V ++ GG W F Sbjct: 91 ITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF 150 Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158 C+VF+ +DVM CTASI+ LC ISIDRY + P+ Y + + + +A MI +VW Sbjct: 151 GHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY---PVRQNGKCMAKMILSVW 207 Query: 159 VLAFAVSCPLLFGF-NTTGDPTVCSISNP-DFVIYSSVVSFYLPFGVTVLVYARIYVVLK 216 +L+ +++ P LFG+ D VC IS + IYS+ V+FY+P V + +Y +IY + Sbjct: 208 LLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR 267 Query: 217 QRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGEL 276 + K PGFP+ + PD AL G Sbjct: 268 KSAAKHKF-----------PGFPR--VEPDSV-------------IALNG---------- 291 Query: 277 KREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLG 336 KL EV + +N LS LK + + RE+KA + I++G Sbjct: 292 --------------IVKLQKEVEECAN--LSRLLK-HERKNISIFKREQKAATTLGIIVG 334 Query: 337 AFIVCWLPFFLTHVLNTH-CQT-CHVSPELYSAT-TWLGYVNSALNPVIYTTFNIEFRKA 393 AF VCWLPFFL C T C P T WLGY NS +NP IY FN + R Sbjct: 335 AFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTT 394 Query: 394 FLKILSC 400 + +L C Sbjct: 395 YRSLLQC 401 >gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sapiens] Length = 390 Score = 182 bits (463), Expect = 4e-46 Identities = 120/367 (32%), Positives = 182/367 (49%), Gaps = 48/367 (13%) Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98 + LA N V V + R L T NYL+ SLAV DLLV+ LVMP VTG W Sbjct: 59 ITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGR-WTL 117 Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158 ++ CD +++ D+ CTASIL+LC I++DRY A+ V Y + + + +R A+MI VW Sbjct: 118 GQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEY---SAKRTPKRAAVMIALVW 174 Query: 159 VLAFAVSCPLLFGFNTTGDPTVCS-ISNPD---FVIYSSVVSFYLPFGVTVLVYARIYVV 214 V + ++S P F + V + N D + +YS+V +FY P + + +Y RIYV Sbjct: 175 VFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVE 234 Query: 215 LKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGG--PGFQER 272 + R K+ R + Q ++ P S T++ P Sbjct: 235 ARSRILKQTPNRTGKRLTRA------QLITDSPG--------STSSVTSINSRVPDVPSE 280 Query: 273 GGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVA 332 G + + +S + LE +KL + RE+KAT+ + Sbjct: 281 SGSPVYVNQVKVRVSDAL-----LEKKKL------------------MAARERKATKTLG 317 Query: 333 IVLGAFIVCWLPFFLTHVLNTHCQ-TCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFR 391 I+LGAFIVCWLPFF+ ++ C+ C ++ TWLGY+NS +NP+IYT N +F+ Sbjct: 318 IILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFK 377 Query: 392 KAFLKIL 398 +AF K++ Sbjct: 378 QAFHKLI 384 >gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sapiens] Length = 366 Score = 181 bits (460), Expect = 8e-46 Identities = 119/373 (31%), Positives = 184/373 (49%), Gaps = 40/373 (10%) Query: 33 ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPW-VVYLEV 91 +L+ L L N LV A++ R L NYL+ SLAV D LVA LVMP+ +VY + Sbjct: 27 SLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVY--I 84 Query: 92 TGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVA 151 W ++ CD+++++D+ CT SIL+L AI++DRY A+ V Y + + + Sbjct: 85 VRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYAR---KRTPKHAG 141 Query: 152 LMITAVWVLAFAVSCPLLF-GFNTTGDPTVCSISNPDFV--IYSSVVSFYLPFGVTVLVY 208 +MIT VW+++ +S P LF T C I + V IYS+ +FY+P + +++Y Sbjct: 142 IMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILY 201 Query: 209 ARIYVVLKQRRRKRILTR-QNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP 267 +IY K KR +R + N Q L S + +L P Sbjct: 202 YKIYRAAKTLYHKRQASRIAKEEVNG-------QVLLESGEKSTKSVSTSYVLEKSLSDP 254 Query: 268 GFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKA 327 + + T SL + S +K+S RE+KA Sbjct: 255 -----STDFDKIHSTVRSLRSEFKHEKSWRRQKISG------------------TRERKA 291 Query: 328 TQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFN 387 + ++LGAF++CWLPFF+ ++ C C +S E+ + WLGY+NS +NP+IYT FN Sbjct: 292 ATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFN 351 Query: 388 IEFRKAFLKILSC 400 +F+KAF K++ C Sbjct: 352 EDFKKAFQKLVRC 364 >gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sapiens] Length = 458 Score = 171 bits (434), Expect = 8e-43 Identities = 116/379 (30%), Positives = 190/379 (50%), Gaps = 61/379 (16%) Query: 33 ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVT 92 ALS +I+ + GN LV MAV E+ L TNY ++SLA+AD+LV LVMP + + Sbjct: 57 ALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILY 116 Query: 93 GGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVAL 152 VW R C V+++LDV+ TASI++LCAIS+DRY A+ P+ + ++ + + Sbjct: 117 DYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRT---KAIM 173 Query: 153 MITAVWVLAFAVSCPL-LFGFNTTG----DPTVCSISNPDFVIYSSVVSFYLPFGVTVLV 207 I VW ++ VS P+ + G + T C +++P+FV+ S V+F++P + V+ Sbjct: 174 KIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVIT 233 Query: 208 YARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP 267 Y VL RR+ +L +++ +P L L ++TA Sbjct: 234 YCLTIYVL--RRQALMLLHGHTE---------------EPPGLSLDFLKCCKRNTA---- 272 Query: 268 GFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPL---RE 324 EE + N A + + R+ PRG E Sbjct: 273 ----------EEENSANPNQDQNARRRKKKERR----------------PRGTMQAINNE 306 Query: 325 KKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQ-TCH--VSPELYSATTWLGYVNSALNPV 381 +KA++++ IV F++ W PFF+T++L+ C+ +C+ + +L + W+GYV S +NP+ Sbjct: 307 RKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPL 366 Query: 382 IYTTFNIEFRKAFLKILSC 400 +YT FN +R+AF L C Sbjct: 367 VYTLFNKIYRRAFSNYLRC 385 >gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sapiens] Length = 365 Score = 166 bits (421), Expect = 3e-41 Identities = 117/375 (31%), Positives = 185/375 (49%), Gaps = 74/375 (19%) Query: 47 NGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPW-VVYLEVTGGVWNFSRICCDV 105 N V MA+ + L NYL+ SLAV DLLVA LVMP ++Y+ + W C+V Sbjct: 40 NLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDR--WKLGYFLCEV 97 Query: 106 FVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVS 165 ++++D+ CT SIL+LC I++DRY A+ + Y + + +R ALMI VW ++ +S Sbjct: 98 WLSVDMTCCTCSILHLCVIALDRYWAITNAIEYAR---KRTAKRAALMILTVWTISIFIS 154 Query: 166 CPLLFGFN---TTGDPTVCSISNPD--FVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRR 220 P LF + + P+ C+I + + IYS++ +FY+P + +++Y RIY K + Sbjct: 155 MPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQ 214 Query: 221 KRILTR---------QNS--QCNSVRPGFPQQTLSPDPAHLELKRYYSICQ----DTALG 265 KR +R QNS C + + DP E +++++ + D L Sbjct: 215 KRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPT-TEFEKFHASIRIPPFDNDLD 273 Query: 266 GPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREK 325 PG R +S T RE+ Sbjct: 274 HPG-------------ERQQISST---------------------------------RER 287 Query: 326 KATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTT 385 KA +++ ++LGAFI+ WLPFF+ ++ VS E+ TWLGYVNS +NP++YT+ Sbjct: 288 KAARILGLILGAFILSWLPFFIKELI-VGLSIYTVSSEVADFLTWLGYVNSLINPLLYTS 346 Query: 386 FNIEFRKAFLKILSC 400 FN +F+ AF K++ C Sbjct: 347 FNEDFKLAFKKLIRC 361 >gi|4557265 beta-1-adrenergic receptor [Homo sapiens] Length = 477 Score = 165 bits (417), Expect = 8e-41 Identities = 122/374 (32%), Positives = 182/374 (48%), Gaps = 60/374 (16%) Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98 ++L IV GN LV +A+ K LQT TN ++SLA ADL++ LV+P+ + V G W + Sbjct: 68 IVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATI-VVWGRWEY 126 Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158 C+++ ++DV+ TASI LC I++DRY A+ P YQ ++ R ++ VW Sbjct: 127 GSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARG---LVCTVW 183 Query: 159 VLAFAVS-CPLLFGF---------NTTGDPTVCS-ISNPDFVIYSSVVSFYLPFGVTVLV 207 ++ VS P+L + DP C ++N + I SSVVSFY+P + V Sbjct: 184 AISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFV 243 Query: 208 YARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP 267 Y R++ +++ +K + RP P + P PA P Sbjct: 244 YLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPA----------------PPP 287 Query: 268 GFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQP-RGVPLREKK 326 G R + + AP L+NGR G +P R V LRE+K Sbjct: 288 G------------PPRPAAAAATAP--------LANGR------AGKRRPSRLVALREQK 321 Query: 327 ATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTF 386 A + + I++G F +CWLPFFL +V+ + V L+ WLGY NSA NP+IY Sbjct: 322 ALKTLGIIMGVFTLCWLPFFLANVVKAFHREL-VPDRLFVFFNWLGYANSAFNPIIYCR- 379 Query: 387 NIEFRKAFLKILSC 400 + +FRKAF +L C Sbjct: 380 SPDFRKAFQGLLCC 393 >gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] Length = 408 Score = 155 bits (393), Expect = 5e-38 Identities = 124/375 (33%), Positives = 174/375 (46%), Gaps = 78/375 (20%) Query: 40 ILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFS 99 +LA V GN LV +A+ LQT TN V SLA ADL++ LV+P L +TG W Sbjct: 48 VLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGH-WPLG 106 Query: 100 RICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWV 159 C+++ ++DV+ TASI LCA+++DRY AV P+ Y C R A+++ VWV Sbjct: 107 ATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRY-GALVTKRCARTAVVL--VWV 163 Query: 160 LAFAVS-CPLLFGFNTTG----------DPTVCSI-SNPDFVIYSSVVSFYLPFGVTVLV 207 ++ AVS P++ + G +P C+ SN +V+ SS VSFYLP V + V Sbjct: 164 VSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFV 223 Query: 208 YARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGP 267 YAR++VV TRQ FP + P P+ Sbjct: 224 YARVFVV---------ATRQLRLLRGELGRFPPEESPPAPS------------------- 255 Query: 268 GFQERGGELKREEKTRNSLSP----TIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLR 323 SL+P T AP + G R +PLR Sbjct: 256 ----------------RSLAPAPVGTCAPPEGVPA-------------CGRRPARLLPLR 286 Query: 324 EKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIY 383 E +A + +++G F +CWLPFFL +VL V + A WLGY NSA NP+IY Sbjct: 287 EHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIY 346 Query: 384 TTFNIEFRKAFLKIL 398 + +FR AF ++L Sbjct: 347 CR-SPDFRSAFRRLL 360 >gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] Length = 357 Score = 155 bits (393), Expect = 5e-38 Identities = 109/365 (29%), Positives = 170/365 (46%), Gaps = 64/365 (17%) Query: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98 L+ A N LV +L+ R + LV S+AV+D+LVA LVMP + E++G W Sbjct: 50 LVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQL 109 Query: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158 R C +++ DV+ CTASI N+ AI++DRY ++ + Y T + +MI W Sbjct: 110 GRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSN---VMIALTW 166 Query: 159 VLAFAVS-CPLLFGFNTT--GDPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVV 214 L+ +S PLLFG+ T C +S P + ++S+V +FYLP V + VY +IY Sbjct: 167 ALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKA 226 Query: 215 LKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGG 274 K R+ +R+ + + + + + P + R+ ++ FQ G Sbjct: 227 AK----FRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVT---------FQPE-G 272 Query: 275 ELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIV 334 + RE+K E++A MV I+ Sbjct: 273 DTWREQK------------------------------------------EQRAALMVGIL 290 Query: 335 LGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAF 394 +G F++CW+PFFLT +++ C +C + S WLGY NS NP+IYT FN + AF Sbjct: 291 IGVFVLCWIPFFLTELISPLC-SCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAF 349 Query: 395 LKILS 399 S Sbjct: 350 KNFFS 354 >gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] Length = 481 Score = 154 bits (388), Expect = 2e-37 Identities = 108/378 (28%), Positives = 186/378 (49%), Gaps = 48/378 (12%) Query: 33 ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVT 92 AL +I+ + GN LV +AV E+ LQ TNY ++SLAVADLLV VMP + + Sbjct: 58 ALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMF 117 Query: 93 GGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVA- 151 +W + C ++ LDV+ TASI++LCAIS+DRY A+ P+ Q + R A Sbjct: 118 EAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQ----ANQYNSRATAF 173 Query: 152 LMITAVWVLAFAVSCPL-LFGFNTTGD---PTVCSISNP---DFVIYSSVVSFYLPFGVT 204 + IT VW+++ ++ P+ + G T D C ++ DF+++ S+ +F+ P + Sbjct: 174 IKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIM 233 Query: 205 VLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTAL 264 ++ Y ++ + ++K L + P Q L+ +R +T Sbjct: 234 IVTY---FLTIHALQKKAYLVKNK----------PPQRLTWLTVSTVFQR-----DETPC 275 Query: 265 GGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLRE 324 P ++++ NS T+ + S + K S +S E Sbjct: 276 SSPEKVAMLDGSRKDKALPNSGDETLMRRTS-TIGKKSVQTIS---------------NE 319 Query: 325 KKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVS--PELYSATTWLGYVNSALNPVI 382 ++A++++ IV F++ W PFF+T++ C +C+ + L W+GYV+S +NP++ Sbjct: 320 QRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLV 379 Query: 383 YTTFNIEFRKAFLKILSC 400 YT FN FR AF + ++C Sbjct: 380 YTLFNKTFRDAFGRYITC 397 >gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapiens] Length = 440 Score = 147 bits (371), Expect = 2e-35 Identities = 115/394 (29%), Positives = 180/394 (45%), Gaps = 78/394 (19%) Query: 19 NSTGASQARPHA------YYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLA 72 NST A A P + + A + C +I N L+ + + AL+ T+N+ +VSL Sbjct: 10 NSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLF 69 Query: 73 VADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAV 132 +DL+V +VMP + L G W +R C ++ DVM C+ASILNLC IS+DRY + Sbjct: 70 TSDLMVGLVVMPPAM-LNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLI 128 Query: 133 VMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGD-----PTVCS-ISNP 186 + P+ Y+ + R +AL++ A + A A PLL G++ G P C +++ Sbjct: 129 LSPLRYK--LRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASL 186 Query: 187 DFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPD 246 FV+ +S ++F+LP G Y RI + + +Q Q S+ G Q Sbjct: 187 PFVLVASGLTFFLPSGAICFTYCRILLAAR---------KQAVQVASLTTGMASQASET- 236 Query: 247 PAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRL 306 L++ R PG + S + R+L+ Sbjct: 237 ---LQVPR---------TPRPGVE------------------------SADSRRLATKHS 260 Query: 307 STSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYS 366 +LK A+ + I+LG F V WLPFF+ +++ C +SP L+ Sbjct: 261 RKALK---------------ASLTLGILLGMFFVTWLPFFVANIVQAVCDC--ISPGLFD 303 Query: 367 ATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400 TWLGY NS +NP+IY F +F++A + L C Sbjct: 304 VLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPC 337 >gi|194018562 histamine receptor H3 [Homo sapiens] Length = 445 Score = 137 bits (345), Expect = 2e-32 Identities = 118/431 (27%), Positives = 185/431 (42%), Gaps = 56/431 (12%) Query: 8 SGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYL 67 SG L A A A A LI+A V GN LV +A + + +L+T N+ Sbjct: 13 SGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFF 72 Query: 68 VVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISID 127 +++LA++D LV +P V +TG W F R C +++ +D ++CT+S N+ IS D Sbjct: 73 LLNLAISDFLVGAFCIPLYVPYVLTGR-WTFGRGLCKLWLVVDYLLCTSSAFNIVLISYD 131 Query: 128 RYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFN-TTGDPTVCS---- 182 R+ +V V Y+ Q RR + VWVLAF + P + + +G ++ Sbjct: 132 RFLSVTRAVSYR--AQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCY 189 Query: 183 ---ISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFP 239 N F+I +S + F+ PF IY+ +++R R R L P Sbjct: 190 AEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLR-LDGAREAAGPEPPPEA 248 Query: 240 QQTLSPDPA-----------HLELKRY-------YSICQDTALGG-------------PG 268 Q + P P + L RY + + LGG G Sbjct: 249 QPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSG 308 Query: 269 FQERGGELKREEKTRNSLSPTIAPKLSLEVR-KLSNGRLSTSLKLGPLQPRGVPLREKKA 327 RG E R K + S A SLE R K+ + + +L R++K Sbjct: 309 SSSRGTERPRSLKRGSKPS---ASSASLEKRMKMVSQSFTQRFRLS---------RDRKV 356 Query: 328 TQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFN 387 + +A+++ F +CW P+ L ++ C V Y + WL + NSA+NPV+Y + Sbjct: 357 AKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCH 416 Query: 388 IEFRKAFLKIL 398 FR+AF K+L Sbjct: 417 HSFRRAFTKLL 427 >gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens] Length = 479 Score = 137 bits (344), Expect = 2e-32 Identities = 120/437 (27%), Positives = 188/437 (43%), Gaps = 81/437 (18%) Query: 38 ALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMP-WVVYLEVTGGVW 96 +L L V GN LV +++ R LQT NY + SLA ADL++ M + VY + G W Sbjct: 41 SLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVY--IIKGYW 98 Query: 97 NFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITA 156 + CD+++ LD ++ AS++NL IS DRY V P+ Y + + + LMI A Sbjct: 99 PLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTY---PARRTTKMAGLMIAA 155 Query: 157 VWVLAFAVSCP-LLFGFNTTGDPTV----CSI---SNPDFVIYSSVVSFYLPFGVTVLVY 208 WVL+F + P +LF G TV C I SNP +++ +FYLP + ++Y Sbjct: 156 AWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLY 215 Query: 209 ARIYVVLKQRRRKR-------------ILTRQNSQCNSVR---PG--------------F 238 I + + R K + SV+ PG Sbjct: 216 IHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEA 275 Query: 239 PQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSL-SPTIAP----- 292 P L P P + K + + + EL E T ++ +P + P Sbjct: 276 PPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNP 335 Query: 293 -----KLSLEVRKLSNGRLSTSLKLGPLQPRGV----------------PLREK------ 325 K+ + V K + T++++ P P G+ +R+K Sbjct: 336 ASRWSKIQI-VTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAAR 394 Query: 326 --KATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIY 383 K T+ + +L AFI+ W P+ + ++NT CQ+C + ++S WL YVNS +NP Y Sbjct: 395 ERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSC-IPDTVWSIGYWLCYVNSTINPACY 453 Query: 384 TTFNIEFRKAFLKILSC 400 N F+K F +L C Sbjct: 454 ALCNATFKKTFRHLLLC 470 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.325 0.137 0.424 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,930,443 Number of Sequences: 37866 Number of extensions: 667821 Number of successful extensions: 3771 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 357 Number of HSP's successfully gapped in prelim test: 268 Number of HSP's that attempted gapping in prelim test: 2269 Number of HSP's gapped (non-prelim): 1138 length of query: 400 length of database: 18,247,518 effective HSP length: 104 effective length of query: 296 effective length of database: 14,309,454 effective search space: 4235598384 effective search space used: 4235598384 T: 11 A: 40 X1: 15 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.6 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.