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Search of human proteins with 88501741
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|88501741 TRIO and F-actin binding protein isoform 2 [Homo
sapiens]
(431 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|88501741 TRIO and F-actin binding protein isoform 2 [Homo sap... 877 0.0
gi|88501740 TRIO and F-actin binding protein isoform 1 [Homo sap... 806 0.0
gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sap... 676 0.0
gi|50980301 myosin phosphatase-Rho interacting protein isoform 2... 236 2e-62
gi|50980307 myosin phosphatase-Rho interacting protein isoform 1... 236 2e-62
gi|50897850 KIAA1914 protein isoform 1 [Homo sapiens] 50 4e-06
gi|24308338 KIAA1914 protein isoform 2 [Homo sapiens] 50 4e-06
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 48 2e-05
gi|154354979 myosin X [Homo sapiens] 48 2e-05
gi|93102364 SWAP-70 protein [Homo sapiens] 46 6e-05
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 44 2e-04
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 44 2e-04
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 44 2e-04
gi|154146189 dedicator of cytokinesis 10 [Homo sapiens] 44 3e-04
gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [... 42 0.001
gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [... 42 0.001
gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [H... 42 0.001
gi|169169586 PREDICTED: hypothetical protein [Homo sapiens] 41 0.002
gi|219689123 pleckstrin homology domain containing, family A mem... 41 0.002
gi|19923493 pleckstrin homology domain containing, family A memb... 41 0.002
gi|55741447 pleckstrin homology domain containing, family H (wit... 41 0.002
gi|148746195 trichohyalin [Homo sapiens] 41 0.002
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ... 41 0.002
gi|4505531 oxysterol binding protein [Homo sapiens] 40 0.003
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 40 0.004
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 40 0.004
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 40 0.004
gi|217416392 pleckstrin homology domain containing, family H (wi... 40 0.004
gi|239047795 pleckstrin homology domain containing, family A mem... 39 0.007
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 39 0.007
>gi|88501741 TRIO and F-actin binding protein isoform 2 [Homo
sapiens]
Length = 431
Score = 877 bits (2265), Expect = 0.0
Identities = 431/431 (100%), Positives = 431/431 (100%)
Query: 1 MGGWKGPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAREPRPRSCLLLPPPWGAAM 60
MGGWKGPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAREPRPRSCLLLPPPWGAAM
Sbjct: 1 MGGWKGPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAREPRPRSCLLLPPPWGAAM 60
Query: 61 TPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADEL 120
TPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADEL
Sbjct: 61 TPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADEL 120
Query: 121 DGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPD 180
DGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPD
Sbjct: 121 DGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPD 180
Query: 181 VTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQ 240
VTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQ
Sbjct: 181 VTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQ 240
Query: 241 ASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAP 300
ASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAP
Sbjct: 241 ASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAP 300
Query: 301 LTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQ 360
LTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQ
Sbjct: 301 LTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQ 360
Query: 361 ALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQLVGVITVPVLQTRPLSSERLCDLPK 420
ALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQLVGVITVPVLQTRPLSSERLCDLPK
Sbjct: 361 ALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQLVGVITVPVLQTRPLSSERLCDLPK 420
Query: 421 VTPPAGLKGGI 431
VTPPAGLKGGI
Sbjct: 421 VTPPAGLKGGI 431
>gi|88501740 TRIO and F-actin binding protein isoform 1 [Homo
sapiens]
Length = 652
Score = 806 bits (2082), Expect = 0.0
Identities = 395/395 (100%), Positives = 395/395 (100%)
Query: 1 MGGWKGPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAREPRPRSCLLLPPPWGAAM 60
MGGWKGPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAREPRPRSCLLLPPPWGAAM
Sbjct: 1 MGGWKGPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAREPRPRSCLLLPPPWGAAM 60
Query: 61 TPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADEL 120
TPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADEL
Sbjct: 61 TPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADEL 120
Query: 121 DGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPD 180
DGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPD
Sbjct: 121 DGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPD 180
Query: 181 VTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQ 240
VTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQ
Sbjct: 181 VTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQ 240
Query: 241 ASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAP 300
ASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAP
Sbjct: 241 ASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAP 300
Query: 301 LTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQ 360
LTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQ
Sbjct: 301 LTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQ 360
Query: 361 ALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQ 395
ALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQ
Sbjct: 361 ALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQ 395
>gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sapiens]
Length = 2365
Score = 676 bits (1745), Expect = 0.0
Identities = 347/385 (90%), Positives = 351/385 (91%), Gaps = 2/385 (0%)
Query: 13 KEGPEARRRAAERGGGGGGGG--VPAPRSPAREPRPRSCLLLPPPWGAAMTPDLLNFKKG 70
K+ A +R AE G G V + R P P + LL PDLLNFKKG
Sbjct: 1724 KQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPTLFNPFLLSLGVLRWRRPDLLNFKKG 1783
Query: 71 WMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCT 130
WMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCT
Sbjct: 1784 WMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCT 1843
Query: 131 DVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKE 190
DVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKE
Sbjct: 1844 DVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKE 1903
Query: 191 NALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPA 250
NALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPA
Sbjct: 1904 NALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPA 1963
Query: 251 RTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLS 310
RTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLS
Sbjct: 1964 RTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLS 2023
Query: 311 EEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWR 370
EEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWR
Sbjct: 2024 EEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWR 2083
Query: 371 LQGEAPQSALRSQEDGHIPPGYISQ 395
LQGEAPQSALRSQEDGHIPPGYISQ
Sbjct: 2084 LQGEAPQSALRSQEDGHIPPGYISQ 2108
Score = 30.8 bits (68), Expect = 2.5
Identities = 41/149 (27%), Positives = 52/149 (34%), Gaps = 44/149 (29%)
Query: 240 QASPQRARTPARTPDR-LAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRR--- 295
Q SP RT ARTP+R L Q LE A + W E P +GP R
Sbjct: 1390 QGSPLPPRTSARTPERELRTQRPLESGQAGPRQPLGVW-----QSQEEPPGSQGPHRHLE 1444
Query: 296 --------GLG--------------APLTEDQQNRLSEEIEKKWQELE--------KLPL 325
GLG A E S E ++ W + E +LP
Sbjct: 1445 RSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQPEAWEEKPTHELPR 1504
Query: 326 RENKRVPLTALLNQSRGERRGPPSDGHEA 354
KR PLT S E G P++ ++
Sbjct: 1505 ELGKRSPLT-----SPPENWGGPAESSQS 1528
Score = 30.0 bits (66), Expect = 4.2
Identities = 46/207 (22%), Positives = 70/207 (33%), Gaps = 15/207 (7%)
Query: 189 KENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRART 248
+EN S + Q P + RA +R PR + QR L TQ R
Sbjct: 765 QENLRTSCTRQDNPRTSSPNRA-----TRDNPRTSCAQRDNLRASSPIRATQQDNPRTCI 819
Query: 249 PARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNR 308
P + Q++ + + + R D + P T+ + R
Sbjct: 820 QQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQSFSFQRDNPGTSSSQCCTQKENLR 879
Query: 309 LSEEIEK-KWQE-LEKLPLRENKRVPLTALL---NQSRGERRGPPSDGHEALEKEVQALR 363
S +W P R NK +P + QS G R PS K+ +
Sbjct: 880 PSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSSPSRS-----KQSEVPW 934
Query: 364 AQLEAWRLQGEAPQSALRSQEDGHIPP 390
A + QG+ PQ++ S+ H PP
Sbjct: 935 ASIALRPTQGDRPQTSSPSRPAQHDPP 961
>gi|50980301 myosin phosphatase-Rho interacting protein isoform 2
[Homo sapiens]
Length = 1025
Score = 236 bits (603), Expect = 2e-62
Identities = 162/413 (39%), Positives = 217/413 (52%), Gaps = 38/413 (9%)
Query: 6 GPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAR----EPRPRSCLLLPPPWGAAMT 61
GP + +RA R PAP A P R+ L ++T
Sbjct: 324 GPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDASASPLSPHRRAKSLDRRSTEPSVT 383
Query: 62 PDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELD 121
PDLLNFKKGW++ E G QWKKHWFVL D SL+YYRDS AEEA +LD
Sbjct: 384 PDLLNFKKGWLTKQYEDG-------------QWKKHWFVLADQSLRYYRDSVAEEAADLD 430
Query: 122 GEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDV 181
GEIDL +C DVTEY VQRNYGFQIHTK+ +TLSAMTSGIRRNWI+ + K V PT+APDV
Sbjct: 431 GEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMKHVHPTTAPDV 490
Query: 182 TKLSDSNKENALHSYSTQKGPLKAGEQRAG----SEVISRGGPRKADGQRQALDYVELSP 237
T K + S+ T P + E G + SR R+ +G+ + D+ E P
Sbjct: 491 TSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRP 550
Query: 238 LTQASPQR---ARTPARTPDRL---AKQEELERDLAQRSEERRKWF---EATDS-RTPEV 287
+ QA Q PA T + L A+ ELER+ A+R EERRK F +ATD T +
Sbjct: 551 IQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDATDGPGTEDA 610
Query: 288 PAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTAL-LNQSRGERRG 346
R G P+++ + + + EIE++W ++E PLRE K+VP+ + L+ G R
Sbjct: 611 ALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRL 670
Query: 347 PPSDGHEALEKEVQALRAQ----LEAWRLQGEAPQSALRSQEDGHIPPGYISQ 395
+ LEKE++ + + LE RL + + AL ++ GY+ Q
Sbjct: 671 STHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAR--EGYVLQ 721
>gi|50980307 myosin phosphatase-Rho interacting protein isoform 1
[Homo sapiens]
Length = 1038
Score = 236 bits (603), Expect = 2e-62
Identities = 162/413 (39%), Positives = 217/413 (52%), Gaps = 38/413 (9%)
Query: 6 GPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAR----EPRPRSCLLLPPPWGAAMT 61
GP + +RA R PAP A P R+ L ++T
Sbjct: 324 GPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDASASPLSPHRRAKSLDRRSTEPSVT 383
Query: 62 PDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELD 121
PDLLNFKKGW++ E G QWKKHWFVL D SL+YYRDS AEEA +LD
Sbjct: 384 PDLLNFKKGWLTKQYEDG-------------QWKKHWFVLADQSLRYYRDSVAEEAADLD 430
Query: 122 GEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDV 181
GEIDL +C DVTEY VQRNYGFQIHTK+ +TLSAMTSGIRRNWI+ + K V PT+APDV
Sbjct: 431 GEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMKHVHPTTAPDV 490
Query: 182 TKLSDSNKENALHSYSTQKGPLKAGEQRAG----SEVISRGGPRKADGQRQALDYVELSP 237
T K + S+ T P + E G + SR R+ +G+ + D+ E P
Sbjct: 491 TSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRP 550
Query: 238 LTQASPQR---ARTPARTPDRL---AKQEELERDLAQRSEERRKWF---EATDS-RTPEV 287
+ QA Q PA T + L A+ ELER+ A+R EERRK F +ATD T +
Sbjct: 551 IQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDATDGPGTEDA 610
Query: 288 PAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTAL-LNQSRGERRG 346
R G P+++ + + + EIE++W ++E PLRE K+VP+ + L+ G R
Sbjct: 611 ALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRL 670
Query: 347 PPSDGHEALEKEVQALRAQ----LEAWRLQGEAPQSALRSQEDGHIPPGYISQ 395
+ LEKE++ + + LE RL + + AL ++ GY+ Q
Sbjct: 671 STHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAR--EGYVLQ 721
>gi|50897850 KIAA1914 protein isoform 1 [Homo sapiens]
Length = 818
Score = 50.1 bits (118), Expect = 4e-06
Identities = 55/254 (21%), Positives = 94/254 (37%), Gaps = 21/254 (8%)
Query: 80 EPPSPSLTTTS------TSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVT 133
EP SL T+S SQWK W + D+ L +Y+D + + + L C V
Sbjct: 348 EPVERSLETSSYLNVLVNSQWKSRWCSVRDNHLHFYQDRNRSKVAQ--QPLSLVGCEVVP 405
Query: 134 EYAVQRNYGFQI-HTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENA 192
+ + Y F+I H + + L A +S +W+ L + P+ + +
Sbjct: 406 DPSPDHLYSFRILHKGEELAKLEAKSSEEMGHWLGLLLSESGSKTDPEEFTYDYVDADRV 465
Query: 193 LHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQA-SPQRARTPAR 251
S K L +++ G D Q + D V+LS LT A P TP
Sbjct: 466 SCIVSAAKNSLLLMQRKFSEPNTYIDGLPSQDRQEELYDDVDLSELTAAVEPTEEATPVA 525
Query: 252 TPDRLAKQEELERDL-----------AQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAP 300
+ + + DL + +++ D+ T +PA GP P
Sbjct: 526 DDPNERESDRVYLDLTPVKSFLHGPSSAQAQASSPTLSCLDNATEALPADSGPGPTPDEP 585
Query: 301 LTEDQQNRLSEEIE 314
+ +N +++E
Sbjct: 586 CIKCPENLGEQQLE 599
>gi|24308338 KIAA1914 protein isoform 2 [Homo sapiens]
Length = 814
Score = 50.1 bits (118), Expect = 4e-06
Identities = 55/254 (21%), Positives = 94/254 (37%), Gaps = 21/254 (8%)
Query: 80 EPPSPSLTTTS------TSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVT 133
EP SL T+S SQWK W + D+ L +Y+D + + + L C V
Sbjct: 348 EPVERSLETSSYLNVLVNSQWKSRWCSVRDNHLHFYQDRNRSKVAQ--QPLSLVGCEVVP 405
Query: 134 EYAVQRNYGFQI-HTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENA 192
+ + Y F+I H + + L A +S +W+ L + P+ + +
Sbjct: 406 DPSPDHLYSFRILHKGEELAKLEAKSSEEMGHWLGLLLSESGSKTDPEEFTYDYVDADRV 465
Query: 193 LHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQA-SPQRARTPAR 251
S K L +++ G D Q + D V+LS LT A P TP
Sbjct: 466 SCIVSAAKNSLLLMQRKFSEPNTYIDGLPSQDRQEELYDDVDLSELTAAVEPTEEATPVA 525
Query: 252 TPDRLAKQEELERDL-----------AQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAP 300
+ + + DL + +++ D+ T +PA GP P
Sbjct: 526 DDPNERESDRVYLDLTPVKSFLHGPSSAQAQASSPTLSCLDNATEALPADSGPGPTPDEP 585
Query: 301 LTEDQQNRLSEEIE 314
+ +N +++E
Sbjct: 586 CIKCPENLGEQQLE 599
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 47.8 bits (112), Expect = 2e-05
Identities = 74/307 (24%), Positives = 118/307 (38%), Gaps = 48/307 (15%)
Query: 94 WKKHWFVLTDSSLKYYRDSTAEEADELDGEI--DLRSCTDVTEYAVQRNYGFQIHTKDAV 151
W + WF L S L Y+ +EE E G I D C +V + F + T +
Sbjct: 233 WAERWFQLQPSCLCYFG---SEECKEKRGIIPLDAHCCVEVLPDRDGKRCMFCVKTANRT 289
Query: 152 YTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGEQRAG 211
Y +SA + R+ W A++ +R A T L K+ K EQR
Sbjct: 290 YEMSASDTRQRQEWTAAIQMAIR-LQAEGKTSLHKDLKQ-------------KRREQREQ 335
Query: 212 SEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSE 271
E +R+A EL L Q ++ R Q + ER L + E
Sbjct: 336 RE------------RRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEE 383
Query: 272 ERRKWF-EATDSRTPEVPAGEGPRRGLGAPL--------TEDQQNRLSEEIEKKWQELEK 322
RR E + ++ E R + A + + Q+ + EE++++ QE +
Sbjct: 384 RRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQ 443
Query: 323 LPLR-----ENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQ 377
L ++ E+ R+ T LL + E+ E E+ ++ RAQ E LQ E Q
Sbjct: 444 LEVKARRDEESVRIAQTRLLEEEE-EKLKQLMQLKEEQERYIE--RAQQEKEELQQEMAQ 500
Query: 378 SALRSQE 384
+ Q+
Sbjct: 501 QSRSLQQ 507
>gi|154354979 myosin X [Homo sapiens]
Length = 2058
Score = 47.8 bits (112), Expect = 2e-05
Identities = 32/128 (25%), Positives = 59/128 (46%), Gaps = 14/128 (10%)
Query: 68 KKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLR 127
K+GW+ +T S WKK WFVL S L Y+ + + E +L G +++R
Sbjct: 1215 KQGWL-------HKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSEE---KLKGTVEVR 1264
Query: 128 SCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSD- 186
+ ++ + + N G I D + L A + W L + V ++ ++ ++ D
Sbjct: 1265 TAKEIIDNTTKEN-GIDIIMADRTFHLIAESPEDASQWFSVLSQ-VHASTDQEIQEMHDE 1322
Query: 187 -SNKENAL 193
+N +NA+
Sbjct: 1323 QANPQNAV 1330
Score = 34.3 bits (77), Expect = 0.22
Identities = 35/114 (30%), Positives = 54/114 (47%), Gaps = 11/114 (9%)
Query: 90 STSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVT--EYAVQRNYGF---Q 144
S+ + KK WFVLT +SL YY+ S+ + A +L G + L S V + + + G+
Sbjct: 1410 SSLKLKKRWFVLTHNSLDYYK-SSEKNALKL-GTLVLNSLCSVVPPDEKIFKETGYWNVT 1467
Query: 145 IHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVT---KLSDSNKENALHS 195
++ + Y L W A+ + V T AP T +L KEN L+S
Sbjct: 1468 VYGRKHCYRLYTKLLNEATRWSSAI-QNVTDTKAPIDTPTQQLIQDIKENCLNS 1520
>gi|93102364 SWAP-70 protein [Homo sapiens]
Length = 585
Score = 46.2 bits (108), Expect = 6e-05
Identities = 69/301 (22%), Positives = 116/301 (38%), Gaps = 37/301 (12%)
Query: 94 WKKHWFVLTDSSLKYYRDSTAEEADELDGEI--DLRSCTDVTEYAVQRNYGFQIHTKDAV 151
W + WFVL + + YY +E+ + G+I D C + + F + D
Sbjct: 227 WTERWFVLKPNIISYY---VSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLVKCFDKT 283
Query: 152 YTLSAMTSGIRRNWIEALRKTV---RPTSAPDVTKLSDSNKENALHSYSTQK-------- 200
+ +SA ++ WI+A+ T+ + S P + KE + Q+
Sbjct: 284 FEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKE 343
Query: 201 ----GPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRL 256
K E A + + R A+ +++ L TQ Q + ++L
Sbjct: 344 LQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQ-------TQVELQARFSTELEREKL 396
Query: 257 AKQEELERDLAQRSEERRKWF----EATDSRTPEVPAGEGPRRGLGAPLT-EDQQNRLSE 311
+Q ++E +AQ+S E ++ E D A E R+ T Q RL E
Sbjct: 397 IRQ-QMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLE 455
Query: 312 EIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRL 371
E K ELEK L + + + T Q +R +AL++ ++ L QLE R
Sbjct: 456 EESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLK---EQALQEAMEQLE-QLELERK 511
Query: 372 Q 372
Q
Sbjct: 512 Q 512
>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 44.3 bits (103), Expect = 2e-04
Identities = 32/108 (29%), Positives = 50/108 (46%), Gaps = 7/108 (6%)
Query: 73 SILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDV 132
SIL+E S S + +K+ FVLT ++L YY + G I+++ V
Sbjct: 5 SILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSR-KGSIEIKKIRCV 63
Query: 133 TEY------AVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVR 174
+ V+R Y FQI KD + + A R W++AL+K +R
Sbjct: 64 EKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIR 111
>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 44.3 bits (103), Expect = 2e-04
Identities = 32/108 (29%), Positives = 50/108 (46%), Gaps = 7/108 (6%)
Query: 73 SILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDV 132
SIL+E S S + +K+ FVLT ++L YY + G I+++ V
Sbjct: 5 SILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSR-KGSIEIKKIRCV 63
Query: 133 TEY------AVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVR 174
+ V+R Y FQI KD + + A R W++AL+K +R
Sbjct: 64 EKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIR 111
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
sapiens]
Length = 2564
Score = 44.3 bits (103), Expect = 2e-04
Identities = 43/175 (24%), Positives = 73/175 (41%), Gaps = 25/175 (14%)
Query: 7 PGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAR---EPRPRSCLLLPPPWGAAMTPD 63
P + R ++ P+ RRR R GG GGG + +PA+ P P PPP
Sbjct: 2369 PDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAPAQGGSAPAPP-----PPPTHTVQHEG 2423
Query: 64 LLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGE 123
L K+ LD + +S W + VL+ L +Y+DS + G
Sbjct: 2424 FLLRKRE----LD--------ANRKSSNRSWVSLYCVLSKGELGFYKDSKGPASGSTHGG 2471
Query: 124 IDL----RSCTDVTEYAVQRNYGFQIHTKD-AVYTLSAMTSGIRRNWIEALRKTV 173
L ++ ++V ++ + F++ T+D + + L A W+EA+ +V
Sbjct: 2472 EPLLSLHKATSEVASDYKKKKHVFKLQTQDGSEFLLQAKDEEEMNGWLEAVASSV 2526
>gi|154146189 dedicator of cytokinesis 10 [Homo sapiens]
Length = 2186
Score = 43.9 bits (102), Expect = 3e-04
Identities = 41/147 (27%), Positives = 64/147 (43%), Gaps = 17/147 (11%)
Query: 67 FKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLT---DSS--LKYYRDSTAEEADELD 121
FK GW+ G S T + +KK +F LT D+S + +Y+D + E
Sbjct: 183 FKSGWLY----KGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISK--EPK 236
Query: 122 GEIDLRSCTDVTEYAVQRNYGFQIHTKDAVY-TLSAMTSGIRRNWIEALRKTVR-----P 175
G I L SCT V + R Y F++ D Y L+A T WI L + ++ P
Sbjct: 237 GCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGP 296
Query: 176 TSAPDVTKLSDSNKENALHSYSTQKGP 202
T+L+D ++ +S + + P
Sbjct: 297 LQGRRSTELTDLGLDSLDNSVTCECTP 323
>gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1
[Homo sapiens]
Length = 438
Score = 42.0 bits (97), Expect = 0.001
Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 16/174 (9%)
Query: 91 TSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQI-HTKD 149
+++WKK W +L SSL +Y + AE+A DG ++L T ++ + F+I H +
Sbjct: 60 SNKWKKFWVILKGSSLYWYSNQMAEKA---DGFVNLPDFTVERASECKKKHAFKISHPQI 116
Query: 150 AVYTLSAMTSGIRRNWIEALRKTV--RPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGE 207
+ +A W+ L V + ++ D S+S +E+ + T P +
Sbjct: 117 KTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQT 176
Query: 208 QRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEE 261
Q ++ S P G + +E +TP+ P L+K+ +
Sbjct: 177 QSLTAQQASSSSP-SLSGTSYSFSSLE---------NTVKTPSSFPSSLSKERQ 220
>gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1
[Homo sapiens]
Length = 438
Score = 42.0 bits (97), Expect = 0.001
Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 16/174 (9%)
Query: 91 TSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQI-HTKD 149
+++WKK W +L SSL +Y + AE+A DG ++L T ++ + F+I H +
Sbjct: 60 SNKWKKFWVILKGSSLYWYSNQMAEKA---DGFVNLPDFTVERASECKKKHAFKISHPQI 116
Query: 150 AVYTLSAMTSGIRRNWIEALRKTV--RPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGE 207
+ +A W+ L V + ++ D S+S +E+ + T P +
Sbjct: 117 KTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQT 176
Query: 208 QRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEE 261
Q ++ S P G + +E +TP+ P L+K+ +
Sbjct: 177 QSLTAQQASSSSP-SLSGTSYSFSSLE---------NTVKTPSSFPSSLSKERQ 220
>gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [Homo
sapiens]
Length = 437
Score = 42.0 bits (97), Expect = 0.001
Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 16/174 (9%)
Query: 91 TSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQI-HTKD 149
+++WKK W +L SSL +Y + AE+A DG ++L T ++ + F+I H +
Sbjct: 59 SNKWKKFWVILKGSSLYWYSNQMAEKA---DGFVNLPDFTVERASECKKKHAFKISHPQI 115
Query: 150 AVYTLSAMTSGIRRNWIEALRKTV--RPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGE 207
+ +A W+ L V + ++ D S+S +E+ + T P +
Sbjct: 116 KTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQT 175
Query: 208 QRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEE 261
Q ++ S P G + +E +TP+ P L+K+ +
Sbjct: 176 QSLTAQQASSSSP-SLSGTSYSFSSLE---------NTVKTPSSFPSSLSKERQ 219
>gi|169169586 PREDICTED: hypothetical protein [Homo sapiens]
Length = 251
Score = 41.2 bits (95), Expect = 0.002
Identities = 23/55 (41%), Positives = 28/55 (50%), Gaps = 12/55 (21%)
Query: 19 RRRAAERGGGGGGG-----------GVPAPRSPAREPRPRSCLLLPPPWGAAMTP 62
R+R ++GGGGGGG G P +PAR PRP C P P G A +P
Sbjct: 3 RKRPHQQGGGGGGGQGRHRHSSRAPGTRTPATPARSPRPPLCAPRPAP-GRAQSP 56
>gi|219689123 pleckstrin homology domain containing, family A member
5 isoform 2 [Homo sapiens]
Length = 1105
Score = 41.2 bits (95), Expect = 0.002
Identities = 33/109 (30%), Positives = 47/109 (43%), Gaps = 8/109 (7%)
Query: 88 TTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRS---CTDVTEYAVQRNYGFQ 144
+T WKK WFVL+D L YYRD E+ + + G I L S +E + R Y F+
Sbjct: 73 STGMKLWKKRWFVLSDLCLFYYRD---EKEEGILGSILLPSFQIALLTSEDHINRKYAFK 129
Query: 145 -IHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENA 192
H Y T W++A+ + P V ++ ENA
Sbjct: 130 AAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEP-VKRVDKITSENA 177
>gi|19923493 pleckstrin homology domain containing, family A member
5 isoform 1 [Homo sapiens]
Length = 1116
Score = 41.2 bits (95), Expect = 0.002
Identities = 33/109 (30%), Positives = 47/109 (43%), Gaps = 8/109 (7%)
Query: 88 TTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRS---CTDVTEYAVQRNYGFQ 144
+T WKK WFVL+D L YYRD E+ + + G I L S +E + R Y F+
Sbjct: 181 STGMKLWKKRWFVLSDLCLFYYRD---EKEEGILGSILLPSFQIALLTSEDHINRKYAFK 237
Query: 145 -IHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENA 192
H Y T W++A+ + P V ++ ENA
Sbjct: 238 AAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEP-VKRVDKITSENA 285
>gi|55741447 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 1 [Homo sapiens]
Length = 1364
Score = 41.2 bits (95), Expect = 0.002
Identities = 21/81 (25%), Positives = 41/81 (50%), Gaps = 3/81 (3%)
Query: 94 WKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYT 153
WK+ WFVL + YY+ S ++ + G++DL S + + + FQ+ ++ Y
Sbjct: 595 WKRRWFVLRQGQIMYYK-SPSDVIRKPQGQVDLNSRCQIVR--GEGSQTFQLISEKKTYY 651
Query: 154 LSAMTSGIRRNWIEALRKTVR 174
L+A + + WI L+ ++
Sbjct: 652 LTADSPSLLEEWIRVLQSLLK 672
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/128 (29%), Positives = 58/128 (45%), Gaps = 11/128 (8%)
Query: 258 KQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKW 317
+QE E+ L + EERR W + R E E RR L DQ+ EE ++W
Sbjct: 439 EQERREQRLKREQEERRDWLK----REEETERHEQERR--KQQLKRDQE----EERRERW 488
Query: 318 QELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQ 377
+LE+ RE + L + + ERR E E+ Q LR++ + R Q E +
Sbjct: 489 LKLEEEERREQQE-RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE 547
Query: 378 SALRSQED 385
L+ +E+
Sbjct: 548 QLLKREEE 555
Score = 35.8 bits (81), Expect = 0.077
Identities = 30/128 (23%), Positives = 60/128 (46%), Gaps = 14/128 (10%)
Query: 258 KQEELER-DLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKK 316
K+EE+ER + +R E+R K E + R ++ +E+Q+ R +++ ++
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLLK------------SEEQEERRQQQLRRE 650
Query: 317 WQELEKLPL-RENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEA 375
QE + L RE + L L + E R E E+ + +++++ W+ Q E+
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710
Query: 376 PQSALRSQ 383
A +S+
Sbjct: 711 EADARQSK 718
Score = 35.4 bits (80), Expect = 0.10
Identities = 45/179 (25%), Positives = 70/179 (39%), Gaps = 18/179 (10%)
Query: 212 SEVISRGGPRKADGQRQALDYVEL-----SPLTQASPQRARTPARTPDRLAKQEELERDL 266
S+V SR PRK +GQR+ + E S L +RA R ++EE RD
Sbjct: 717 SKVYSR--PRKQEGQRRRQEQEEKRRRRESELQWQEEERAH-------RQQQEEEQRRDF 767
Query: 267 AQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLR 326
+ + K + P E R L A + ++ R E E+K Q + R
Sbjct: 768 TWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRER 827
Query: 327 ENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQL----EAWRLQGEAPQSALR 381
E + L R ER + + L+++ + R+Q + WR Q E + R
Sbjct: 828 EKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRR 886
Score = 34.7 bits (78), Expect = 0.17
Identities = 55/231 (23%), Positives = 93/231 (40%), Gaps = 27/231 (11%)
Query: 162 RRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPR 221
RR+W++ +T R +L +E + L+ E+R E R
Sbjct: 454 RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK----LEEEERREQQE------RR 503
Query: 222 KADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERD-LAQRSEERRKWFEAT 280
+ +R+ + E Q +R + R+ +L +++E R+ L +R EE+R E
Sbjct: 504 EQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR 563
Query: 281 DSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEK------KWQELEKLPLRENKRVPLT 334
+ R E R L E +Q RL E E+ K +E+E+L E + L
Sbjct: 564 EQRLKR--EQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLK 621
Query: 335 ALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQED 385
+ ERR + L+ E Q R Q + R Q E + L+ +E+
Sbjct: 622 R--EEPEEERR------QQLLKSEEQEERRQQQLRREQQERREQRLKREEE 664
Score = 33.5 bits (75), Expect = 0.38
Identities = 47/186 (25%), Positives = 81/186 (43%), Gaps = 29/186 (15%)
Query: 207 EQRAGSEVISRGGPRKADGQRQALDYVELSP----LTQASPQRARTPARTPDRLAKQEEL 262
EQ G E +R R+ + +RQ EL L + P++ R R + ++EEL
Sbjct: 1061 EQLLGEERETR---RRQELERQYRKEEELQQEEEQLLREEPEKRRRQERER-QCREEEEL 1116
Query: 263 ERDLAQ-----RSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKW 317
+++ Q R + RR+ E EV E L E+ + R +E+E+++
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQL------LREEPEKRRRQELERQY 1170
Query: 318 QELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQ 377
+E E+L E + LL + + +RR E +E + L+ Q R + E +
Sbjct: 1171 REEEELQQEEEQ------LLREEQEKRR----QERERQYREEEELQRQKRKQRYRDEDQR 1220
Query: 378 SALRSQ 383
S L+ Q
Sbjct: 1221 SDLKWQ 1226
Score = 32.0 bits (71), Expect = 1.1
Identities = 40/183 (21%), Positives = 75/183 (40%), Gaps = 11/183 (6%)
Query: 204 KAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAK--QEE 261
K ++R + + + K +R+ + E L + PQR R ++L K ++E
Sbjct: 226 KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE 285
Query: 262 LERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELE 321
L R+ + +++++ R + E RR E Q+ R +E E++ Q+L
Sbjct: 286 LRRERQEEEQQQQRLRREQQLRRKQ----EEERREQQEERREQQERREQQE-ERREQQLR 340
Query: 322 KLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALR 381
RE + L + ERR + E+ Q LR + + R Q + LR
Sbjct: 341 ----REQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLR 396
Query: 382 SQE 384
++
Sbjct: 397 REQ 399
Score = 31.2 bits (69), Expect = 1.9
Identities = 36/142 (25%), Positives = 59/142 (41%), Gaps = 4/142 (2%)
Query: 251 RTPDRLAKQEELERD-LAQRSEERR--KWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQN 307
R RL +++E RD L +R EERR + + R + E R L +Q+
Sbjct: 562 RREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVER-LEQEERREQRL 620
Query: 308 RLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLE 367
+ E E++ Q+L K +E +R Q R E+R + E LE+ ++ +
Sbjct: 621 KREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680
Query: 368 AWRLQGEAPQSALRSQEDGHIP 389
+ E Q R + IP
Sbjct: 681 REQELAEEEQEQARERIKSRIP 702
>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
sapiens]
Length = 1048
Score = 40.8 bits (94), Expect = 0.002
Identities = 28/96 (29%), Positives = 42/96 (43%), Gaps = 7/96 (7%)
Query: 88 TTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDL---RSCTDVTEYAVQRNYGFQ 144
++ QW K WFVL D L YY+D E+ + + G I L R + R + F+
Sbjct: 71 SSGVKQWNKRWFVLVDRCLFYYKD---EKEESILGSIPLLSFRVAAVQPSDNISRKHTFK 127
Query: 145 I-HTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAP 179
H Y SA + + WI+A+ + R P
Sbjct: 128 AEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPP 163
>gi|4505531 oxysterol binding protein [Homo sapiens]
Length = 807
Score = 40.4 bits (93), Expect = 0.003
Identities = 60/225 (26%), Positives = 85/225 (37%), Gaps = 40/225 (17%)
Query: 2 GGWKGP-----GQRRGKEGPEARRR-----AAERGGGGGGGGVPAPRSPAREPRPRSCLL 51
GG GP G RG GP + AA GG G G G A PA P
Sbjct: 22 GGGAGPPVVGGGGGRGDAGPGSGAASGTVVAAAAGGPGPGAGGVAAAGPAPAPPTGGS-- 79
Query: 52 LPPPWGAAMTPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRD 111
G + + ++GW+ T +++ WFVL++ L YYR
Sbjct: 80 -----GGSGAGGSGSAREGWLF------------KWTNYIKGYQRRWFVLSNGLLSYYR- 121
Query: 112 STAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDA-VYTLSAMTSGIRRNWIEALR 170
S AE G I+L + V+ + F I A Y L A + R+ W+ AL
Sbjct: 122 SKAEMRHTCRGTINLAT----ANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALE 177
Query: 171 KTVRPTSAPDVTKLSDSNKENALHSYS-TQKGPLKAGEQRAGSEV 214
A V L++S++ S S T K L+ + S+V
Sbjct: 178 L----AKAKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKV 218
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 40.0 bits (92), Expect = 0.004
Identities = 59/229 (25%), Positives = 93/229 (40%), Gaps = 38/229 (16%)
Query: 167 EALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQ 226
EA KT+R + T+ + + L + K L GS V R +A G
Sbjct: 1323 EAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL-------GSRV--RAMEAEAAGL 1373
Query: 227 RQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDS---- 282
R+ L+ E + +A + A+ + +QEE L E RR+ ++
Sbjct: 1374 REQLEE-EAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQR 1432
Query: 283 ---RTPEVPAGEGPRRGLGAPLTE-----DQQNRLSEEIEKKWQELEKLPLRENKRVPLT 334
+T V E RR L L + +QQ +L +EKK ++ ++L L E K L
Sbjct: 1433 LAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL-LAEEKAAVLR 1491
Query: 335 ALLNQSRGERRG---------------PPSDGHEALEKEVQALRAQLEA 368
A+ + R E G + E LE++ +ALRA+LEA
Sbjct: 1492 AVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEA 1540
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 40.0 bits (92), Expect = 0.004
Identities = 59/229 (25%), Positives = 93/229 (40%), Gaps = 38/229 (16%)
Query: 167 EALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQ 226
EA KT+R + T+ + + L + K L GS V R +A G
Sbjct: 1315 EAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL-------GSRV--RAMEAEAAGL 1365
Query: 227 RQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDS---- 282
R+ L+ E + +A + A+ + +QEE L E RR+ ++
Sbjct: 1366 REQLEE-EAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQR 1424
Query: 283 ---RTPEVPAGEGPRRGLGAPLTE-----DQQNRLSEEIEKKWQELEKLPLRENKRVPLT 334
+T V E RR L L + +QQ +L +EKK ++ ++L L E K L
Sbjct: 1425 LAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL-LAEEKAAVLR 1483
Query: 335 ALLNQSRGERRG---------------PPSDGHEALEKEVQALRAQLEA 368
A+ + R E G + E LE++ +ALRA+LEA
Sbjct: 1484 AVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEA 1532
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 40.0 bits (92), Expect = 0.004
Identities = 59/229 (25%), Positives = 93/229 (40%), Gaps = 38/229 (16%)
Query: 167 EALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQ 226
EA KT+R + T+ + + L + K L GS V R +A G
Sbjct: 1356 EAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLAL-------GSRV--RAMEAEAAGL 1406
Query: 227 RQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDS---- 282
R+ L+ E + +A + A+ + +QEE L E RR+ ++
Sbjct: 1407 REQLEE-EAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQR 1465
Query: 283 ---RTPEVPAGEGPRRGLGAPLTE-----DQQNRLSEEIEKKWQELEKLPLRENKRVPLT 334
+T V E RR L L + +QQ +L +EKK ++ ++L L E K L
Sbjct: 1466 LAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL-LAEEKAAVLR 1524
Query: 335 ALLNQSRGERRG---------------PPSDGHEALEKEVQALRAQLEA 368
A+ + R E G + E LE++ +ALRA+LEA
Sbjct: 1525 AVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEA 1573
>gi|217416392 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 2 [Homo sapiens]
Length = 1493
Score = 40.0 bits (92), Expect = 0.004
Identities = 24/85 (28%), Positives = 40/85 (47%), Gaps = 3/85 (3%)
Query: 94 WKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYT 153
WK+ WFVL L YY+ S ++ + G I+L + + Q+ T+ Y
Sbjct: 720 WKRRWFVLKGGELLYYK-SPSDVIRKPQGHIELSASCSILR--GDNKQTVQLTTEKHTYY 776
Query: 154 LSAMTSGIRRNWIEALRKTVRPTSA 178
L+A + I WI+ L+ +R +A
Sbjct: 777 LTADSPNILEEWIKVLQNVLRVQAA 801
>gi|239047795 pleckstrin homology domain containing, family A member
7 [Homo sapiens]
Length = 1121
Score = 39.3 bits (90), Expect = 0.007
Identities = 60/234 (25%), Positives = 95/234 (40%), Gaps = 46/234 (19%)
Query: 94 WKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRS---CTDVTEYAVQRNYGFQ-IHT-- 147
WK+ WFVL D L YY+DS E + G I L S E + R Y F+ +HT
Sbjct: 182 WKRRWFVLADYCLFYYKDSREE---AVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGM 238
Query: 148 KDAVYTLS-----AMTSGIR------------RNWIEALRKTV----RPTSAPDVTKLSD 186
+ +Y S A SG+R W+ A+ + R + D+ K+
Sbjct: 239 RALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDMEKVER 298
Query: 187 SNKENALHSYSTQK-GPLKAGEQRAGSEVISRGGPRKADGQRQALDYVEL-SPLTQASPQ 244
A H+ S + G + G R + RG + +RQ + + S +
Sbjct: 299 QAVPQANHTESCHECGRVGPGHTR---DCPHRGHDDIVNFERQEQEGEQYRSQRDPLEGK 355
Query: 245 RARTPARTPDRLAKQEELERDL-----AQRSEERRKWFEATDSRTPEVPAGEGP 293
R R+ AR+P A+++ L DL Q+++ +R + +PA GP
Sbjct: 356 RDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQRA------EKNGMLPASYGP 403
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 39.3 bits (90), Expect = 0.007
Identities = 24/77 (31%), Positives = 35/77 (45%), Gaps = 2/77 (2%)
Query: 94 WKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYT 153
WK WF + + Y TA++A+ LD IDL S + + F+I T V T
Sbjct: 64 WKSRWFFYDERKCQLYYSRTAQDANPLD-SIDLSSAVFDCKADAEEGI-FEIKTPSRVIT 121
Query: 154 LSAMTSGIRRNWIEALR 170
L A T W++ L+
Sbjct: 122 LKAATKQAMLYWLQQLQ 138
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.131 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,521,459
Number of Sequences: 37866
Number of extensions: 1169630
Number of successful extensions: 10110
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 136
Number of HSP's successfully gapped in prelim test: 439
Number of HSP's that attempted gapping in prelim test: 8424
Number of HSP's gapped (non-prelim): 1836
length of query: 431
length of database: 18,247,518
effective HSP length: 105
effective length of query: 326
effective length of database: 14,271,588
effective search space: 4652537688
effective search space used: 4652537688
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.