Search of human proteins with 88196790

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
         (1476 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|88196790 coiled-coil domain containing 88 [Homo sapiens]          2853   0.0  
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...   522   e-148
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...   518   e-146
gi|148762940 DVL-binding protein DAPLE [Homo sapiens]                 513   e-145
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       199   2e-50
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       199   2e-50
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        199   2e-50
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        199   2e-50
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        199   2e-50
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        199   2e-50
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        199   2e-50
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        199   2e-50
gi|148746195 trichohyalin [Homo sapiens]                              160   8e-39
gi|21735548 centrosomal protein 2 [Homo sapiens]                      159   1e-38
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]          155   3e-37
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]          155   3e-37
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]          155   3e-37
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]               153   1e-36
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...   148   4e-35
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        147   7e-35
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   141   4e-33
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   141   4e-33
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   140   1e-32
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   140   1e-32
gi|16262452 cingulin [Homo sapiens]                                   132   2e-30
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   129   2e-29
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   128   4e-29
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi...   123   1e-27
gi|115648142 centrosomal protein 164kDa [Homo sapiens]                119   3e-26
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            116   2e-25

>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
          Length = 1476

 Score = 2853 bits (7396), Expect = 0.0
 Identities = 1476/1476 (100%), Positives = 1476/1476 (100%)

Query: 1    MEGGKGPRLRDFLSGSLATWALGLAGLVGEAEDSEGEEEEEEEEPPLWLEKRFLRLSDGA 60
            MEGGKGPRLRDFLSGSLATWALGLAGLVGEAEDSEGEEEEEEEEPPLWLEKRFLRLSDGA
Sbjct: 1    MEGGKGPRLRDFLSGSLATWALGLAGLVGEAEDSEGEEEEEEEEPPLWLEKRFLRLSDGA 60

Query: 61   LLLRVLGIIAPSSRGGPRMLRGLDGPAAWRVWNLNHLWGRLRDFYQEELQLLILSPPPDL 120
            LLLRVLGIIAPSSRGGPRMLRGLDGPAAWRVWNLNHLWGRLRDFYQEELQLLILSPPPDL
Sbjct: 61   LLLRVLGIIAPSSRGGPRMLRGLDGPAAWRVWNLNHLWGRLRDFYQEELQLLILSPPPDL 120

Query: 121  QTLGFDPLSEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQ 180
            QTLGFDPLSEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQ
Sbjct: 121  QTLGFDPLSEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQ 180

Query: 181  PGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLR 240
            PGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLR
Sbjct: 181  PGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLR 240

Query: 241  PEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQ 300
            PEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQ
Sbjct: 241  PEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQ 300

Query: 301  EAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLS 360
            EAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLS
Sbjct: 301  EAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLS 360

Query: 361  GVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENV 420
            GVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENV
Sbjct: 361  GVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENV 420

Query: 421  ELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQG 480
            ELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQG
Sbjct: 421  ELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQG 480

Query: 481  QPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSV 540
            QPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSV
Sbjct: 481  QPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSV 540

Query: 541  LEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQS 600
            LEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQS
Sbjct: 541  LEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQS 600

Query: 601  PASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQL 660
            PASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQL
Sbjct: 601  PASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQL 660

Query: 661  EEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESL 720
            EEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESL
Sbjct: 661  EEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESL 720

Query: 721  ASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAH 780
            ASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAH
Sbjct: 721  ASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAH 780

Query: 781  REAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSE 840
            REAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSE
Sbjct: 781  REAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSE 840

Query: 841  AAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAAL 900
            AAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAAL
Sbjct: 841  AAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAAL 900

Query: 901  ERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPA 960
            ERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPA
Sbjct: 901  ERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPA 960

Query: 961  GLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLL 1020
            GLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLL
Sbjct: 961  GLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLL 1020

Query: 1021 QSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKA 1080
            QSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKA
Sbjct: 1021 QSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKA 1080

Query: 1081 LAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAE 1140
            LAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAE
Sbjct: 1081 LAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAE 1140

Query: 1141 RERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELER 1200
            RERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELER
Sbjct: 1141 RERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELER 1200

Query: 1201 AQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELL 1260
            AQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELL
Sbjct: 1201 AQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELL 1260

Query: 1261 ERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRTKKGSWLADKV 1320
            ERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRTKKGSWLADKV
Sbjct: 1261 ERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRTKKGSWLADKV 1320

Query: 1321 KRLMRPRREGGPPGGLRLGADGAGSTESLGGPPETELPEGREADGTGSPSPAPMRRAQSS 1380
            KRLMRPRREGGPPGGLRLGADGAGSTESLGGPPETELPEGREADGTGSPSPAPMRRAQSS
Sbjct: 1321 KRLMRPRREGGPPGGLRLGADGAGSTESLGGPPETELPEGREADGTGSPSPAPMRRAQSS 1380

Query: 1381 LCLRDETLAGGQRRKLSSRFPVGRSSESFSPGDTPRQRFRQRHPGPLGAPVSHSKGPGVG 1440
            LCLRDETLAGGQRRKLSSRFPVGRSSESFSPGDTPRQRFRQRHPGPLGAPVSHSKGPGVG
Sbjct: 1381 LCLRDETLAGGQRRKLSSRFPVGRSSESFSPGDTPRQRFRQRHPGPLGAPVSHSKGPGVG 1440

Query: 1441 WENSAETLQEHETDANREGPEVQEPEKRPLTPSLSQ 1476
            WENSAETLQEHETDANREGPEVQEPEKRPLTPSLSQ
Sbjct: 1441 WENSAETLQEHETDANREGPEVQEPEKRPLTPSLSQ 1476


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score =  522 bits (1345), Expect = e-148
 Identities = 418/1439 (29%), Positives = 716/1439 (49%), Gaps = 154/1439 (10%)

Query: 7    PRLRDFLSGSLATWALGLAGLVGEAEDSEGEEEEEEEEPPLWLEKRFLRLSDGALLLRVL 66
            P L  F++  L TW      L        G   +E           ++ L DG  L +V+
Sbjct: 8    PLLEQFMTSPLVTWVKTFGPLAA----GNGTNLDE-----------YVALVDGVFLNQVM 52

Query: 67   GIIAPSSRGGPRMLRGLDGPAAWRVWNLNHLWGRLRDFYQEELQLLILSPPPDLQTLGFD 126
              I P      R+ + ++  A+ R+ NL+ L  +++ +YQE LQ LI+   P++  +G +
Sbjct: 53   LQINPKLES-QRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKN 111

Query: 127  PLSEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGVV 186
            P SE+  E+++ +L LLLG +VQC+ +E FI  IQGL  + ++ +AA IQEVT     V 
Sbjct: 112  PFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENV- 170

Query: 187  LALSGPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSR 246
              L   +  +++  ++E L +++   L +L  ERD  ++ + EL  ER+ L   P A S 
Sbjct: 171  FDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSS 230

Query: 247  A--PAEGPS-------HHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRR 297
            A  P   P         HL+++LA+AKA++RRLRQELEEK E LLD + E++ +E E++R
Sbjct: 231  AQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKR 290

Query: 298  LRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEER 357
            L+QE   L   A+ A +YR+E +ALRE+A R+ +L+ E+ R +ERL   E YK+++EE +
Sbjct: 291  LQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK 350

Query: 358  VLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAE 417
              + VL  +K +LE+QLE  R R  +LHE ++ENL L+ +L +   E D  R ++++L E
Sbjct: 351  EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME 410

Query: 418  ENVELELELQRSLEPP------------PGSPGEAPLAGAAPSLQDEVREAEAGRLRTLE 465
            EN+ LE+  ++S++                   EAP      SL  EV E  + RL  LE
Sbjct: 411  ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP----QKSLGHEVNELTSSRLLKLE 466

Query: 466  RENRELRGLLQVLQ----GQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFD-HSPQGLVQ 520
             EN+ L   ++ L+       G    +L+  +E+  L    E  +  +  +  S Q    
Sbjct: 467  MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN 526

Query: 521  KARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESG 580
             ++D   +   L    ++++ E S    +  + + +     + +     Q S      + 
Sbjct: 527  LSKDLMKEKAQL-EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS------AE 579

Query: 581  SPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWG 640
            + V+  E   K    S  ++ + ++  +    +I+  +L   + +G  A   EL  E   
Sbjct: 580  ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIK-KELEHYKEKGERAE--ELENELHH 636

Query: 641  LRQEGP--EHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKP 698
            L +E    + K    + +  ++E  E  N  L     + E R+  + L+         + 
Sbjct: 637  LEKENELLQKKITNLKITCEKIEALEQENSEL-----ERENRKLKKTLDSFKNLTFQLES 691

Query: 699  QQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELE---AQARKL 755
             +K    L+ +  E     ESL     +   L+ E  +L  + E L   LE   A  +K 
Sbjct: 692  LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751

Query: 756  E-------AQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLR---EAVEAAGQELE 805
            E         + E  RL K L  + +   +   E +    E   L+   E ++ + + LE
Sbjct: 752  ERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811

Query: 806  SASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQV-------LESEGRQ--- 855
               +E ++L +  +   ++++Q E+E  RLR Q+E  +  ++        LE E +    
Sbjct: 812  QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871

Query: 856  ----------HLEEAERERRE--KEA---------LQAELEKAVVRGKELGARLEHLQRE 894
                       L+E E+E +E  K A         L+ +L    ++ +++   LE L  E
Sbjct: 872  EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931

Query: 895  LEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRA-------LQ 947
            LE+  L ++  L +++S   RY+ LE +LE+ L+ +   KEE +  L+ R         Q
Sbjct: 932  LEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQ 991

Query: 948  LEEELFQLRQGPAGLGPKKRAEPQLVETQNV-----------------------RLIEVE 984
            L +EL  +++    L  ++  E  +  +  +                       RLIEVE
Sbjct: 992  LRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVE 1051

Query: 985  RSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQ 1044
            R+NA L AEK AL+ QL+ LE Q  +LQ +   L  Q+   QE ++ LQ + + L+++  
Sbjct: 1052 RNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENS 1111

Query: 1045 ELHR--------------KLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEA 1090
             L+               +   LE E  +  + +E+ +    +L++DH+ L  L  RQ +
Sbjct: 1112 TLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQAS 1171

Query: 1091 ELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHR 1150
            E E L+ +H  LK+  + LE+ HR+L+ R+ QL  Q+  +E  E  L  E+E+++ +   
Sbjct: 1172 EYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKN 1231

Query: 1151 QRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQL 1210
               +  E ++L  E+DR     ++L +E   LQ +   L+  L   +LE+ +LE +  +L
Sbjct: 1232 HETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKL 1291

Query: 1211 RESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHL 1270
            +E  QQLD+++ +L  QCELL+QL+   EEENR LL ++Q L  +NR LLE+++ES+D  
Sbjct: 1292 KEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLF 1351

Query: 1271 HREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRTKKGSWLADKVKRLMRPRRE 1329
            H EQR+Y+D+LN LRR+K+KL EKIMDQY+  +P P PR ++G+W+  K+++L++ +++
Sbjct: 1352 HVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSP-PR-RRGNWITLKMRKLIKSKKD 1408


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score =  518 bits (1334), Expect = e-146
 Identities = 418/1440 (29%), Positives = 716/1440 (49%), Gaps = 155/1440 (10%)

Query: 7    PRLRDFLSGSLATWALGLAGLVGEAEDSEGEEEEEEEEPPLWLEKRFLRLSDGALLLRVL 66
            P L  F++  L TW      L        G   +E           ++ L DG  L +V+
Sbjct: 8    PLLEQFMTSPLVTWVKTFGPLAA----GNGTNLDE-----------YVALVDGVFLNQVM 52

Query: 67   GIIAPSSRGGPRMLRGLDGPAAWRVWNLNHLWGRLRDFYQEELQLLILSPPPDLQTLGFD 126
              I P      R+ + ++  A+ R+ NL+ L  +++ +YQE LQ LI+   P++  +G +
Sbjct: 53   LQINPKLES-QRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKN 111

Query: 127  PLSEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGVV 186
            P SE+  E+++ +L LLLG +VQC+ +E FI  IQGL  + ++ +AA IQEVT     V 
Sbjct: 112  PFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENV- 170

Query: 187  LALSGPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSR 246
              L   +  +++  ++E L +++   L +L  ERD  ++ + EL  ER+ L   P A S 
Sbjct: 171  FDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSS 230

Query: 247  A--PAEGPS-------HHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRR 297
            A  P   P         HL+++LA+AKA++RRLRQELEEK E LLD + E++ +E E++R
Sbjct: 231  AQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKR 290

Query: 298  LRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEER 357
            L+QE   L   A+ A +YR+E +ALRE+A R+ +L+ E+ R +ERL   E YK+++EE +
Sbjct: 291  LQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK 350

Query: 358  VLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAE 417
              + VL  +K +LE+QLE  R R  +LHE ++ENL L+ +L +   E D  R ++++L E
Sbjct: 351  EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME 410

Query: 418  ENVELELELQRSLEPP------------PGSPGEAPLAGAAPSLQDEVREAEAGRLRTLE 465
            EN+ LE+  ++S++                   EAP      SL  EV E  + RL  LE
Sbjct: 411  ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP----QKSLGHEVNELTSSRLLKLE 466

Query: 466  RENRELRGLLQVLQ----GQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFD-HSPQGLVQ 520
             EN+ L   ++ L+       G    +L+  +E+  L    E  +  +  +  S Q    
Sbjct: 467  MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN 526

Query: 521  KARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESG 580
             ++D   +   L    ++++ E S    +  + + +     + +     Q S      + 
Sbjct: 527  LSKDLMKEKAQL-EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS------AE 579

Query: 581  SPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWG 640
            + V+  E   K    S  ++ + ++  +    +I+  +L   + +G  A   EL  E   
Sbjct: 580  ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIK-KELEHYKEKGERAE--ELENELHH 636

Query: 641  LRQEGP--EHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKP 698
            L +E    + K    + +  ++E  E  N  L     + E R+  + L+         + 
Sbjct: 637  LEKENELLQKKITNLKITCEKIEALEQENSEL-----ERENRKLKKTLDSFKNLTFQLES 691

Query: 699  QQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELE---AQARKL 755
             +K    L+ +  E     ESL     +   L+ E  +L  + E L   LE   A  +K 
Sbjct: 692  LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751

Query: 756  E-------AQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLR---EAVEAAGQELE 805
            E         + E  RL K L  + +   +   E +    E   L+   E ++ + + LE
Sbjct: 752  ERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811

Query: 806  SASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQV-------LESEGRQ--- 855
               +E ++L +  +   ++++Q E+E  RLR Q+E  +  ++        LE E +    
Sbjct: 812  QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871

Query: 856  ----------HLEEAERERRE--KEA---------LQAELEKAVVRGKELGARLEHLQRE 894
                       L+E E+E +E  K A         L+ +L    ++ +++   LE L  E
Sbjct: 872  EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931

Query: 895  LEQAALERQEFLREKES-QHQRYQGLEQRLEAELQAAATSKEEALMELKTRA-------L 946
            LE+  L ++  L +++S    RY+ LE +LE+ L+ +   KEE +  L+ R         
Sbjct: 932  LEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ 991

Query: 947  QLEEELFQLRQGPAGLGPKKRAEPQLVETQNV-----------------------RLIEV 983
            QL +EL  +++    L  ++  E  +  +  +                       RLIEV
Sbjct: 992  QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1051

Query: 984  ERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQG 1043
            ER+NA L AEK AL+ QL+ LE Q  +LQ +   L  Q+   QE ++ LQ + + L+++ 
Sbjct: 1052 ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1111

Query: 1044 QELHR--------------KLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQE 1089
              L+               +   LE E  +  + +E+ +    +L++DH+ L  L  RQ 
Sbjct: 1112 STLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQA 1171

Query: 1090 AELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGH 1149
            +E E L+ +H  LK+  + LE+ HR+L+ R+ QL  Q+  +E  E  L  E+E+++ +  
Sbjct: 1172 SEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENK 1231

Query: 1150 RQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQ 1209
                +  E ++L  E+DR     ++L +E   LQ +   L+  L   +LE+ +LE +  +
Sbjct: 1232 NHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK 1291

Query: 1210 LRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDH 1269
            L+E  QQLD+++ +L  QCELL+QL+   EEENR LL ++Q L  +NR LLE+++ES+D 
Sbjct: 1292 LKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDL 1351

Query: 1270 LHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRTKKGSWLADKVKRLMRPRRE 1329
             H EQR+Y+D+LN LRR+K+KL EKIMDQY+  +P P PR ++G+W+  K+++L++ +++
Sbjct: 1352 FHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSP-PR-RRGNWITLKMRKLIKSKKD 1409


>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
          Length = 2028

 Score =  513 bits (1320), Expect = e-145
 Identities = 422/1408 (29%), Positives = 687/1408 (48%), Gaps = 154/1408 (10%)

Query: 53   FLRLSDGALLLRVLGIIAPSSRGGPRMLRGLDGPAAWRVWNLNHLWGRLRDFYQEELQLL 112
            ++ L DG  L +++  I P      R+ + ++     R+ NL  L   ++ +YQE LQ L
Sbjct: 38   YMDLVDGIFLNQIMLQIDPRPTN-QRINKHVNNDVNLRIQNLTILVRNIKTYYQEVLQQL 96

Query: 113  ILSPPPDLQTLGFDPLSEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELA 172
            I+   P++  +G DPLS +++E+++ VL L+LG +VQCE +E FI  I+ L +E Q+ + 
Sbjct: 97   IVMNLPNVLMIGRDPLSGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIV 156

Query: 173  AAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLL 232
            A IQEVT     V   L   +  ++AP ELE LSRS++  L +L  +RD   + + +L  
Sbjct: 157  AHIQEVTHNQENV-FDLQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECTELIVDLTQ 215

Query: 233  EREPL-CLRPEAPSRAPAEGPS------------HHLALQLANAKAQLRRLRQELEEKAE 279
            ER+ L    P +P ++ +   +             HLA++LA+ KA+LRR+RQELE+K E
Sbjct: 216  ERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTE 275

Query: 280  LLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRC 339
             L+D++ EV  L  E+++++QE   L+  A+ A  YR+E ++LRE+A R+ RL+ EL RC
Sbjct: 276  QLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRC 335

Query: 340  RERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLG 399
            +E+L   + YK+++EE R  + +L  +KA+LEEQL AAR R  ++HE ++ENL L+++L 
Sbjct: 336  KEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLH 395

Query: 400  EAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQD-------- 451
            +   + D+ + ++++L EEN+ LE+  ++S+        E         L D        
Sbjct: 396  DLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVF 455

Query: 452  EVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEA-------PREDPVLPVLEEA 504
            E+ E  + R+  LE+EN+ L+     +QG       L E+        +E+  L    E 
Sbjct: 456  ELNECASSRILKLEKENQSLQS---TIQGLRDASLVLEESGLKCGELEKENHQLSKKIEK 512

Query: 505  PQTPVAFD-HSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQ 563
             QT +  +  S Q L   + +     L      L S +E           D ++ +  L 
Sbjct: 513  LQTQLEREKQSNQDLETLSEE-----LIREKEQLQSDMETLKADKARQIKDLEQEKDHLN 567

Query: 564  AAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGE 623
             A        WS +E           +      +L    + A  +    + +  QL    
Sbjct: 568  RAM-------WSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDL 620

Query: 624  TEGREAPQG--ELVPEAWGLRQEGPE--HKPGPSEPSSVQLEEQEGPNQGLDLATGQAEA 679
             + +E  +   +L  E   L++E      K    E ++ ++E  E  +QGL L       
Sbjct: 621  EQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRK 680

Query: 680  -----REHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEV 734
                 +    +LEG  RD    K        L   V         LA    E + L  E 
Sbjct: 681  SLDTLQNVSLQLEGLERD---NKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREK 737

Query: 735  AQLRRKAE---ALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHRE-AEAQAWEQ 790
             +LR+  +   ALG + E      ++ + E  RL + L  +         E  E +A  Q
Sbjct: 738  EELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQ 797

Query: 791  ARLR--EAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEE---- 844
            A  R  EA+  A  +LE A ++R+AL + +A   ++++  E+E  RL  Q E  +     
Sbjct: 798  ALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDD 857

Query: 845  ---RMQVLESEGRQ-------------HLEEAERERREKE-----------ALQAELEKA 877
               ++  +E E R               L+E E++ R+              L+ +L   
Sbjct: 858  STAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLE 917

Query: 878  VVRGKELGARLEHLQRELEQAALERQEFLREKES-QHQRYQGLEQRLEAELQAAATSKEE 936
             ++ ++L + L+ L +ELE+  L R+  L+E +S    +Y+ LE R E+ L+     KEE
Sbjct: 918  KLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEE 977

Query: 937  ALMELKTRA-------LQLEEELFQLR-------------------------------QG 958
             ++ L+ +         QLE EL  L+                               QG
Sbjct: 978  KIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQG 1037

Query: 959  PAGLGP-KKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQE 1017
                GP  K A  +L+  ++ R IE+ER+NA L AEK  L+ QLQHLE Q  +   +   
Sbjct: 1038 KEAWGPGHKEATMELLRVKD-RAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILT 1096

Query: 1018 LLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVL--------------EEEVRAARQS 1063
            L  QS   QEH++ LQ + + L+++   L  +   L              E E  + ++ 
Sbjct: 1097 LQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQ 1156

Query: 1064 QEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQL 1123
            QE+     +ALL+DH+ L  L  RQ AE E L+ +H  LK   R LEL H+EL  RH  +
Sbjct: 1157 QEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDM 1216

Query: 1124 QAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQ 1183
              ++A +E +E  L  ERE L Q+         E +RL+ E DR   L  +L  E  EL 
Sbjct: 1217 LKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELH 1276

Query: 1184 GERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENR 1243
                EL+  L   +LE  + + +  +L+E +Q +D+S  +L   CELL++L+   EEEN 
Sbjct: 1277 AHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENH 1336

Query: 1244 QLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLE 1303
             LL+++Q LS++N+ LLE+++E+++  H EQ++Y+D+LNALRR K+KL EKIMDQY+  +
Sbjct: 1337 HLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYD 1396

Query: 1304 PVPLPRTKKGSWLADK-VKRLMRPRREG 1330
            P   P  KK  W+  K + +L++P++EG
Sbjct: 1397 P---PPKKKNHWIGAKALVKLIKPKKEG 1421



 Score = 32.3 bits (72), Expect = 3.5
 Identities = 37/153 (24%), Positives = 54/153 (35%), Gaps = 36/153 (23%)

Query: 551  PDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGP 610
            P +  + A+ P    A  P     +P   G P++  +  +   R +  ++P SVAP Q  
Sbjct: 1715 PPAKKEGAKMPTNFVA--PTVKMAAPTSEGRPLKPGQYVKPNFRLTEAEAPPSVAPRQAQ 1772

Query: 611  -------GTKIQAP---------------------------QLLGGETEGREAPQGELVP 636
                   G   QAP                           +  G E   +E+PQ    P
Sbjct: 1773 PPQSLSLGRPRQAPVPPASHAPASRSASLSRAFSLASADLLRASGPEACKQESPQKLGAP 1832

Query: 637  EAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQG 669
            EA G R+ G      P+ PSS  L  +  P  G
Sbjct: 1833 EALGGRETGSHTLQSPAPPSSHSLARERTPLVG 1865


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  199 bits (505), Expect = 2e-50
 Identities = 333/1276 (26%), Positives = 533/1276 (41%), Gaps = 170/1276 (13%)

Query: 106  QEELQLLILSPPPDLQTLGFDPLSEEA----VEQLEGVLRLLLGASVQCEHRELFIRHIQ 161
            QEELQ L  S   ++Q       + E     +E+   V+RL L A+     R+      +
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT----ERQRGGAEGE 1474

Query: 162  GLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARERD 221
              +L  ++E A A +   Q  A  +      +      AE+E+ SR  +   ++ ARE+ 
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR--VKAEAEAAREKQ 1532

Query: 222  LGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELL 281
               Q L EL L+ E    R        A      L     +A+A+L+  R    EK   L
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592

Query: 282  LDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRER-------AGRLPRLQE 334
               +  +Q     + +LR+EA+  + Q   AE  REEAE   ER       A RL    E
Sbjct: 1593 ---ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649

Query: 335  ELRRCRERLQA-AEAYKSQLEEERVLSGVLEAS----KALLEEQLE--------AARERC 381
            E+ + +   QA AE  K + E E    G  E      + L E++LE         A++R 
Sbjct: 1650 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1709

Query: 382  ARLHETQRENLLLRTRLGEAHA-----ELDSLRHQVDQLAEENVELELELQR---SLEPP 433
            A   E  R  L   T  GE        EL  L+ +     ++  ELE EL +    +E  
Sbjct: 1710 AAEQELIR--LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1767

Query: 434  PGSPGEAPLAGAAPSLQDEVR-EAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAP 492
              S   A     + S + + R EAEAGR R L  E   LR L +             EA 
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE-------------EAK 1814

Query: 493  REDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPD 552
            R+  +    E+A +       + + L +K    G +A  L   A  ++ E  AE  +   
Sbjct: 1815 RQRQLAE--EDAARQRA---EAERVLAEKLAAIG-EATRLKTEAEIALKEKEAENERLRR 1868

Query: 553  SDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGT 612
                EA    Q   ++ QA+     +  + +E + +  +    S L+    +        
Sbjct: 1869 LAEDEA---FQRRRLEEQAA-----QHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920

Query: 613  KIQAPQLLGGETEGREAPQG--ELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGL 670
            +    ++L  +    +A  G  EL  E   +R    +         S +  E E   Q  
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL------RSKEQAELEAARQRQ 1974

Query: 671  DLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE----GALEVQVWEGPIPGESLASGVAE 726
              A  +   RE ++R++ ++        Q+K+       L+ +V E     E      A 
Sbjct: 1975 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2034

Query: 727  QEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAA------RLSKELAQARRAEAEAH 780
            Q  L +E AQ R +AE        Q ++ E Q T         +L  E   ARRA  EA 
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA- 2093

Query: 781  REAEAQA-WEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQS 839
             EA  QA  E A+ R  VE A +  +SA ++ +A  +A AAA + R++ E+E +R     
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153

Query: 840  EAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAA 899
            +AA  + Q  ++E  +H + AE+  R+K  ++ EL    ++ +E   +   L  EL++  
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213

Query: 900  LERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGP 959
             E  E  R      QR Q  E+     +Q    SK +A +E + RAL L +         
Sbjct: 2214 AEATEAAR------QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD--------- 2258

Query: 960  AGLGPKKRAEPQL-VETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQEL 1018
                 K   +  L  E + ++ +  E +   + A++AA   QL   E  L   +  A+++
Sbjct: 2259 -----KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL--AEEDLAQQRALAEKM 2311

Query: 1019 LLQSQRAQEHSSRLQAEKSVLEIQ---GQELHRKLEVLEEEVRAARQSQEETRGQQQALL 1075
            L +  +A + ++RL+AE  +L+ Q    QE  R+L+  E++ + A+Q  EET+G Q+ L 
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ--EDKEQMAQQLAEETQGFQRTL- 2368

Query: 1076 RDHKALAQLQRRQEAELEGLLVRHRDL-KANMRALELAHRELQGRHEQLQAQRASVEAQE 1134
               +A  Q Q    AE E L +R  ++ +A  RA E              AQR   +A+E
Sbjct: 2369 ---EAERQRQLEMSAEAERLKLRVAEMSRAQARAEE-------------DAQRFRKQAEE 2412

Query: 1135 VALLAERERLMQDGHRQRGLEEELRRLQSEHD--RAQMLLAELSRERGELQGERGELRGR 1192
            +     R  L            E++R QS+HD  R +  +AEL RE+ +LQ E      +
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE-----AK 2467

Query: 1193 LARLELERAQLEMQSQQLRESN--QQLDLSACRLTTQCELL------------------- 1231
            L +L+ E  Q   Q Q L+E+   QQ  LS      Q E                     
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527

Query: 1232 TQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKL 1291
             QLR  Q+ + +Q+  E Q L     E   R  E+ + + R+Q E L QL   RR++++L
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE-LQQLEQQRRQQEEL 2586

Query: 1292 V----EKIMDQYRVLE 1303
            +    +++ +Q ++LE
Sbjct: 2587 LAEENQRLREQLQLLE 2602



 Score =  159 bits (401), Expect = 2e-38
 Identities = 300/1197 (25%), Positives = 491/1197 (41%), Gaps = 217/1197 (18%)

Query: 193  DPGELAPAELEMLSR---SLMGTLSKLARERDLGAQ---RLAELLLEREPLCLRPEAPSR 246
            D G   P +  M  R   S      +L +  + GAQ   R    + E + + L+ EA   
Sbjct: 942  DAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACET 1001

Query: 247  APAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALS 306
                   H L L L    A  R   Q + E+ +    +QAEV+GL   + RL  EA    
Sbjct: 1002 RTV----HRLRLPLDKEPA--RECAQRIAEQQK----AQAEVEGLGKGVARLSAEA---- 1047

Query: 307  GQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKS-QLEEERVLSGVLEA 365
                      E+  AL E +   P L+ EL     +L+   +  +  LE+ + +S V+  
Sbjct: 1048 ----------EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1097

Query: 366  SKA------LLEEQLEAARERCARLHETQRENLLLRTRLGEAHAE---LDSLRHQV---- 412
            ++         EEQL+ A+   A L E +     L+    +A A+    D+LR ++    
Sbjct: 1098 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQ 1157

Query: 413  ---DQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENR 469
               ++L + + E ++E++R  E       +      A   Q +VR+      R LE+  R
Sbjct: 1158 EVGERLQQRHGERDVEVERWRE----RVAQLLERWQAVLAQTDVRQ------RELEQLGR 1207

Query: 470  ELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQA 529
            +LR   +                  DP+   L++A +        P    Q  R+   Q 
Sbjct: 1208 QLRYYRE----------------SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE 1251

Query: 530  LDLAPPALDSVLEASAECPQAPDS-----DPQEAESPLQAAAMDPQASDWSPQ--ESGSP 582
              L    ++   E   EC +            E +     A ++P AS       +SGS 
Sbjct: 1252 QALL-EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1310

Query: 583  VETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLR 642
               QE  +     S L +  S         K  +  L   E E R A Q           
Sbjct: 1311 SVIQEYVDLRTHYSELTTLTS------QYIKFISETLRRMEEEERLAEQ----------- 1353

Query: 643  QEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKS 702
            Q   E +      ++++ + Q         A  + EA+E  QR++        ++  ++ 
Sbjct: 1354 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--------EEVVRRE 1405

Query: 703  EGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEA 762
            E A++ Q                ++ +++EE+ QLR+ +EA   E++A+AR+ EA     
Sbjct: 1406 EAAVDAQ---------------QQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSR 1447

Query: 763  ARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAG 822
             R+ +E+   R       R+      E   LR   E A  +   A +E E L   +    
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507

Query: 823  RERRQWERE-GSRLRAQSEAAEERMQVLES--EGRQHLEEAERERREKEALQAELEKAVV 879
            + +RQ E E  SR++A++EAA E+ + L++  E R   EEAER  R     QAE+E+A  
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVERA-- 1560

Query: 880  RGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQ------RLEAELQA---- 929
              +++   LE  QR  E     ++    EK +Q +R    E       R EAE +A    
Sbjct: 1561 --RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1618

Query: 930  -AATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNA 988
             A  ++EEA  EL+   L+  E L +LR     +  +K       E Q     E E    
Sbjct: 1619 EAERAREEAERELERWQLKANEAL-RLRLQAEEVAQQKSLAQAEAEKQKEE-AEREARRR 1676

Query: 989  MLVAEKAALQGQL--QHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQEL 1046
                E+A  Q +L  Q LE Q    +G AQ+ L     A++   RL+AE    E Q Q L
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL----AAEQELIRLRAETEQGEQQRQLL 1732

Query: 1047 HRKLEVLEEEVRAARQSQEE-------TRGQQQALLRDHKALAQLQRRQEAE-----LEG 1094
              +L  L+ E  AA Q ++E        R + + LL   KA A+ + R  +E     LE 
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS-KARAEEESRSTSEKSKQRLEA 1791

Query: 1095 LLVRHRDL---KANMRAL-ELAHRELQGRHEQLQAQRASVE---AQEVALLAERERLMQD 1147
               R R+L    A +RAL E A R+ Q   E    QRA  E   A+++A + E  RL  +
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851

Query: 1148 GHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGE----RGELRGRLARL------E 1197
                   E  L+  ++E++R + L  + + +R  L+ +    + ++  RLA+L      E
Sbjct: 1852 A------EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1905

Query: 1198 LE------------RAQLEMQSQQLRES-------NQQLDLSACRLTTQCELLTQLRSAQ 1238
            LE            R Q+E +   L+ S         +L+L   R+ +  E    LRS +
Sbjct: 1906 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE--DTLRSKE 1963

Query: 1239 EEE-----NRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQK 1290
            + E      RQL AE +   RE  E +++SL + +   R+++  L+++  L+ + ++
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020



 Score =  154 bits (389), Expect = 6e-37
 Identities = 291/1222 (23%), Positives = 499/1222 (40%), Gaps = 233/1222 (19%)

Query: 269  RLRQELEEKAELLLDS---QAEVQGLEAEIRRLRQEAQALSGQAKRAELYREE------- 318
            R+ Q LE    +L  +   Q E++ L  ++R  R+ A  L    + A   +E+       
Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1239

Query: 319  -AEALRERAGRLPRLQEELRRCRERLQAAE------------------AYKSQLE----- 354
             ++A+RE+  +   L EE+ R  E+++  +                   YK+QLE     
Sbjct: 1240 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1299

Query: 355  --EERVLSGVLEASK-------------ALLEEQLEAARERCARLHETQR----ENLLLR 395
              + +V SG     +              L  + ++   E   R+ E +R    +    R
Sbjct: 1300 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359

Query: 396  TRLGEAHAELDSLRHQVDQLAEENVELE---LELQRSLEPPPGSPGEAPLAGAAP--SLQ 450
             RL E  A L+  R   +  A+   + E    ELQ+ ++       EA +       S+Q
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419

Query: 451  DEVRE------------------AEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAP 492
            +E+++                  AE  RLR +E E R +R  L+  + Q GG    L+A 
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQAL 1478

Query: 493  REDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECP---- 548
            R        EEA           + L ++ +D   Q    A   L S ++A AE      
Sbjct: 1479 RAR-----AEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQ 1532

Query: 549  -----------QAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQES--PEKAGRR 595
                       QA +++ +  ++ ++ A     A + + + + + ++++ +   EK  + 
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592

Query: 596  SSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEP 655
                    VA  Q      +  Q        RE  + EL  E W L+          +E 
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL--ERWQLK---------ANEA 1641

Query: 656  SSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGA-----LEVQV 710
              ++L+ +E   Q   LA  +AE ++ +   E   R  A ++  ++ E A      + Q+
Sbjct: 1642 LRLRLQAEEVAQQ-KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1700

Query: 711  WEGPIPGESLA------------SGVAEQEALREEVAQLRRKAEAL---GDELEAQARKL 755
             EG       A             G  +++ L EE+A+L+R+A A      ELEA+  K+
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760

Query: 756  EAQ---------NTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQ---- 802
             A+           E    S      +R EAEA R  E  A E ARLR   E A +    
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQL 1819

Query: 803  -ELESASQEREA---LVEALAAAGRERR----------QWEREGSRLRAQSEAAEERMQV 848
             E ++A Q  EA   L E LAA G   R          + E E  RLR  +E    + + 
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1879

Query: 849  LESEGRQH-------------------------LEEAERERREKE----ALQAELEKAVV 879
            LE +  QH                         +E+  R+RR+ E    AL+A  EKA  
Sbjct: 1880 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1939

Query: 880  RGKELGARL-------EHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQA--- 929
               EL   L       E   R  EQA LE     +    + +R +  E+R++  L A   
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999

Query: 930  AATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAM 989
            AA  ++ AL E++    ++EE   +LR+       ++    Q  E    RL   E+++A 
Sbjct: 2000 AARQRKAALEEVERLKAKVEEAR-RLRERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF 2056

Query: 990  LVAEK-AALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHR 1048
             V +K   LQ  LQ  +  L  L+G A+     ++ A+E  +R+QAE+   + + Q    
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQSRRQ---- 2110

Query: 1049 KLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRA 1108
                  EE    +QS EE     QA  R     A  + R+EAE E    R +  +A +R 
Sbjct: 2111 -----VEEAERLKQSAEE-----QAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAALRQ 2159

Query: 1109 LELAHRELQGRHEQLQAQRASVEAQ-EVALLAERERLMQDGHRQRGLEEELRRLQSEHDR 1167
             + A  E++ +H++   Q    +AQ E  L   R +L +  H++  L+EEL+RL++E   
Sbjct: 2160 KQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218

Query: 1168 AQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQS--------QQLRESNQQLDL 1219
            A    +++  E   ++ +  EL    AR+E E   L ++         Q+  E  +Q+  
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278

Query: 1220 SACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERS--LESRDHLHREQREY 1277
             A RL+   +   +LR   EE+  Q  A  + + +E  + ++ +  L++   L ++Q+E 
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2338

Query: 1278 L-DQLNALRREKQKLVEKIMDQ 1298
              +Q   L+ +K+++ +++ ++
Sbjct: 2339 AQEQARRLQEDKEQMAQQLAEE 2360



 Score =  140 bits (353), Expect = 9e-33
 Identities = 259/1088 (23%), Positives = 436/1088 (40%), Gaps = 161/1088 (14%)

Query: 217  ARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEE 276
            A E+ +  + LAE  LE++       A  R  AE     L  +    + Q + L +EL  
Sbjct: 1679 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1738

Query: 277  KAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAE----------LYREEAEA----- 321
                   +  + Q LEAE+ ++R E + L     RAE            R EAEA     
Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798

Query: 322  LRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVL----EASKALLEEQL--- 374
            L E A RL  L EE +R R+ L   +A + + E ERVL+  L    EA++   E ++   
Sbjct: 1799 LAEEAARLRALAEEAKRQRQ-LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857

Query: 375  --EAARERCARLHET---QRENLL---------LRTRLGEAHAELDSLRHQVDQLAEENV 420
              EA  ER  RL E    QR  L          +  RL +     DS   +   L E+ +
Sbjct: 1858 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1917

Query: 421  -------ELELELQRSLEPPPGSPGEAPL------AGAAPSLQD-EVREAEAGRLRTL-E 465
                   E  L L+ S E       E  L      + A  +L+  E  E EA R R L  
Sbjct: 1918 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1977

Query: 466  RENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDG 525
             E R  R   + +Q     +    EA R+      LEE  +     + + + L ++A   
Sbjct: 1978 EEERRRREAEERVQKSLAAEE---EAARQRKA--ALEEVERLKAKVEEA-RRLRERAEQE 2031

Query: 526  GPQALDLAPPALDSVLEASAECPQ-APDSDPQEAESPLQAAAMDPQASDWSPQESGSPVE 584
              + L LA  A    L+A  +    A     QE +  LQ    +    D    E+ +   
Sbjct: 2032 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ---QEQSVLDQLRGEAEAARR 2088

Query: 585  TQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQE 644
              E  E+A  ++  ++  S         +++  + L    E +   + +    A  LR+E
Sbjct: 2089 AAEEAEEARVQAEREAAQS-------RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141

Query: 645  GPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE- 703
              +     ++     L +++            AE  +H +  E T+R    QK Q + E 
Sbjct: 2142 AEQEAARRAQAEQAALRQKQ---------AADAEMEKHKKFAEQTLR----QKAQVEQEL 2188

Query: 704  GALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAE-------ALGDELEAQARKLE 756
              L +Q+ E       L   +   +A   E A+ R + E          +EL     ++E
Sbjct: 2189 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2248

Query: 757  AQN--------TEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESAS 808
            A+N            R  +E A+  +  AE        A E ARLR+  E      E  +
Sbjct: 2249 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLA 2302

Query: 809  QEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEE----AERER 864
            Q+R AL E +    +E+ Q  +E +RL+A++E  +++ ++ + + R+  E+    A++  
Sbjct: 2303 QQR-ALAEKML---KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358

Query: 865  REKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLE 924
             E +  Q  LE    R  E+ A  E L  +L  A + R +   E+++Q  R Q  E   +
Sbjct: 2359 EETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2416

Query: 925  AELQAAATSKEEALME-LKTRALQLEEELFQLRQGPAGLGPKK------------RAEPQ 971
                  AT ++  L++ L+ +  Q + +  +LR+  A L  +K            ++E  
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476

Query: 972  LVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSR 1031
                Q   L E +      ++EK +L  + + +E +   L+   Q+ + ++Q+ +E   R
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536

Query: 1032 LQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAE 1091
             Q +        QE  R +  +EE  R   +++E  R +Q+ L +      + QRRQ+ E
Sbjct: 2537 QQQQME------QERQRLVASMEEARRRQHEAEEGVRRKQEELQQ-----LEQQRRQQEE 2585

Query: 1092 LEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRA----------------SVEAQ-E 1134
            L  L   ++ L+  ++ LE  HR      E++ A +                 + EA+ E
Sbjct: 2586 L--LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2643

Query: 1135 VALLAERERLMQDGHRQRGL--EEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGR 1192
             +    R ++     ++ G+   EEL+RL   H      LA     R  LQG R  + G 
Sbjct: 2644 HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE-LARREDVRHYLQG-RSSIAGL 2701

Query: 1193 LARLELER 1200
            L +   E+
Sbjct: 2702 LLKATNEK 2709



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 148/629 (23%), Positives = 255/629 (40%), Gaps = 60/629 (9%)

Query: 716  PGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRA 775
            P    A  +AEQ+  + EV  L +    L  E E +   L   +  A  L  EL +    
Sbjct: 1015 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE-KVLALPEPSPAAPTLRSEL-ELTLG 1072

Query: 776  EAEAHREAEAQAWEQARLREAV---EAAGQELESASQEREALVEALAAAGRERRQWEREG 832
            + E  R   A   E+ +    V       +E+  A +E+    +A+ A   E    +   
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1132

Query: 833  SRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQ 892
             +LRAQ+EA +     L  E R   E  ER ++       E+E+   R  +L   LE  Q
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQ 1189

Query: 893  RELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEEL 952
              L Q  + RQ  L +   Q + Y+     L A LQ  A  ++E +  +     Q   E 
Sbjct: 1190 AVLAQTDV-RQRELEQLGRQLRYYRESADPLGAWLQ-DARRRQEQIQAMPLADSQAVRE- 1246

Query: 953  FQLRQGPAGLGPKKRAEPQLVETQNVR---LIEVERSNAMLVAEKAALQGQLQHLEGQLG 1009
             QLRQ  A L   +R   ++ E Q      +  ++     LV  KA L+        +  
Sbjct: 1247 -QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS--PAKKP 1303

Query: 1010 SLQGRAQELLLQSQRAQEHSSRLQAEKS-VLEIQGQELHRKLEVLEEEVRAARQSQEETR 1068
             +Q  ++ ++ +    + H S L    S  ++   + L R    +EEE R A Q + E R
Sbjct: 1304 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR----MEEEERLAEQQRAEER 1359

Query: 1069 ---GQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQA 1125
                + +A L   + LA+   + +A+ E      ++L+  M+  E+  RE      Q Q 
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAER---EAKELQQRMQE-EVVRREEAAVDAQQQK 1415

Query: 1126 QRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGE 1185
            +    E Q++   +E E +     +    E    R++ E    ++ L    R+RG  +GE
Sbjct: 1416 RSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474

Query: 1186 RGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQL 1245
               LR R    E ++ Q + ++++LR                       R  Q+E  R+ 
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLR-----------------------RQVQDESQRKR 1511

Query: 1246 LAEVQALSRENREL-----LERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYR 1300
             AEV+  SR   E       +R+L++ + L  +  E   +L     E+ + V+  ++  +
Sbjct: 1512 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1571

Query: 1301 VLEPVPLPRTKKGSWLADKVKRLMRPRRE 1329
                  L ++K+ S+ A+K  +L R  +E
Sbjct: 1572 RSAEAEL-QSKRASF-AEKTAQLERSLQE 1598



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 131/567 (23%), Positives = 217/567 (38%), Gaps = 69/567 (12%)

Query: 694  AW-QKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAE-ALGDELEAQ 751
            AW ++ Q + +GA     W   +P  S+ + +     L + + + R K E A  DE +  
Sbjct: 530  AWVEENQHRVDGA----EWGVDLP--SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS 583

Query: 752  ARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQER 811
                 A      RL  + A+   +     R  E+       L   V AA +EL   +++ 
Sbjct: 584  PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES-------LHSFVAAATKELMWLNEKE 636

Query: 812  EALVEALAAAGRERRQWEREG-SRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEAL 870
            E  V    +        ++E  S L  + E  E++++ L++ G + L E    R   E+ 
Sbjct: 637  EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 696

Query: 871  QAELEKAVVRGKELGARLEHLQRELEQAALERQEF--LREKESQHQRYQ-GLEQRLEAEL 927
            QA L+       +L   +E     L++ A   Q F  +RE E Q Q+ Q  L ++   + 
Sbjct: 697  QAALQTQWSWMLQLCCCIE---AHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 753

Query: 928  QAAATSKEEALMELKTRALQLEEE------LFQLRQGPAGLGPKKRAEPQ-----LVETQ 976
             A  T  E+ L + +    QL E       L +  +    L P+  A P      L+   
Sbjct: 754  SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC 813

Query: 977  NVRLIEV---ERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQ 1033
            + + +EV   +     LV        ++    G   ++      +   +Q AQE  +RL+
Sbjct: 814  DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE 873

Query: 1034 AEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELE 1093
            A+   L     +LH  ++ L                  Q+L RD     QL R       
Sbjct: 874  AQHQALVTLWHQLHVDMKSLL---------------AWQSLRRD----VQLIRSWS---- 910

Query: 1094 GLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRG 1153
              L   R LK   +   L   EL  +     +Q A     E  L+AERE      H Q+ 
Sbjct: 911  --LATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQ- 967

Query: 1154 LEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELER------AQLEMQS 1207
            L + L +   E  R Q  ++EL   R +L+        RL RL L++      AQ   + 
Sbjct: 968  LLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL-RLPLDKEPARECAQRIAEQ 1026

Query: 1208 QQLRESNQQLDLSACRLTTQCELLTQL 1234
            Q+ +   + L     RL+ + E +  L
Sbjct: 1027 QKAQAEVEGLGKGVARLSAEAEKVLAL 1053


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  199 bits (505), Expect = 2e-50
 Identities = 333/1276 (26%), Positives = 533/1276 (41%), Gaps = 170/1276 (13%)

Query: 106  QEELQLLILSPPPDLQTLGFDPLSEEA----VEQLEGVLRLLLGASVQCEHRELFIRHIQ 161
            QEELQ L  S   ++Q       + E     +E+   V+RL L A+     R+      +
Sbjct: 1423 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT----ERQRGGAEGE 1478

Query: 162  GLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARERD 221
              +L  ++E A A +   Q  A  +      +      AE+E+ SR  +   ++ ARE+ 
Sbjct: 1479 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR--VKAEAEAAREKQ 1536

Query: 222  LGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELL 281
               Q L EL L+ E    R        A      L     +A+A+L+  R    EK   L
Sbjct: 1537 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1596

Query: 282  LDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRER-------AGRLPRLQE 334
               +  +Q     + +LR+EA+  + Q   AE  REEAE   ER       A RL    E
Sbjct: 1597 ---ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1653

Query: 335  ELRRCRERLQA-AEAYKSQLEEERVLSGVLEAS----KALLEEQLE--------AARERC 381
            E+ + +   QA AE  K + E E    G  E      + L E++LE         A++R 
Sbjct: 1654 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1713

Query: 382  ARLHETQRENLLLRTRLGEAHA-----ELDSLRHQVDQLAEENVELELELQR---SLEPP 433
            A   E  R  L   T  GE        EL  L+ +     ++  ELE EL +    +E  
Sbjct: 1714 AAEQELIR--LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1771

Query: 434  PGSPGEAPLAGAAPSLQDEVR-EAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAP 492
              S   A     + S + + R EAEAGR R L  E   LR L +             EA 
Sbjct: 1772 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE-------------EAK 1818

Query: 493  REDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPD 552
            R+  +    E+A +       + + L +K    G +A  L   A  ++ E  AE  +   
Sbjct: 1819 RQRQLAE--EDAARQRA---EAERVLAEKLAAIG-EATRLKTEAEIALKEKEAENERLRR 1872

Query: 553  SDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGT 612
                EA    Q   ++ QA+     +  + +E + +  +    S L+    +        
Sbjct: 1873 LAEDEA---FQRRRLEEQAA-----QHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1924

Query: 613  KIQAPQLLGGETEGREAPQG--ELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGL 670
            +    ++L  +    +A  G  EL  E   +R    +         S +  E E   Q  
Sbjct: 1925 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL------RSKEQAELEAARQRQ 1978

Query: 671  DLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE----GALEVQVWEGPIPGESLASGVAE 726
              A  +   RE ++R++ ++        Q+K+       L+ +V E     E      A 
Sbjct: 1979 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2038

Query: 727  QEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAA------RLSKELAQARRAEAEAH 780
            Q  L +E AQ R +AE        Q ++ E Q T         +L  E   ARRA  EA 
Sbjct: 2039 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA- 2097

Query: 781  REAEAQA-WEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQS 839
             EA  QA  E A+ R  VE A +  +SA ++ +A  +A AAA + R++ E+E +R     
Sbjct: 2098 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2157

Query: 840  EAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAA 899
            +AA  + Q  ++E  +H + AE+  R+K  ++ EL    ++ +E   +   L  EL++  
Sbjct: 2158 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2217

Query: 900  LERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGP 959
             E  E  R      QR Q  E+     +Q    SK +A +E + RAL L +         
Sbjct: 2218 AEATEAAR------QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD--------- 2262

Query: 960  AGLGPKKRAEPQL-VETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQEL 1018
                 K   +  L  E + ++ +  E +   + A++AA   QL   E  L   +  A+++
Sbjct: 2263 -----KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL--AEEDLAQQRALAEKM 2315

Query: 1019 LLQSQRAQEHSSRLQAEKSVLEIQ---GQELHRKLEVLEEEVRAARQSQEETRGQQQALL 1075
            L +  +A + ++RL+AE  +L+ Q    QE  R+L+  E++ + A+Q  EET+G Q+ L 
Sbjct: 2316 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ--EDKEQMAQQLAEETQGFQRTL- 2372

Query: 1076 RDHKALAQLQRRQEAELEGLLVRHRDL-KANMRALELAHRELQGRHEQLQAQRASVEAQE 1134
               +A  Q Q    AE E L +R  ++ +A  RA E              AQR   +A+E
Sbjct: 2373 ---EAERQRQLEMSAEAERLKLRVAEMSRAQARAEE-------------DAQRFRKQAEE 2416

Query: 1135 VALLAERERLMQDGHRQRGLEEELRRLQSEHD--RAQMLLAELSRERGELQGERGELRGR 1192
            +     R  L            E++R QS+HD  R +  +AEL RE+ +LQ E      +
Sbjct: 2417 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE-----AK 2471

Query: 1193 LARLELERAQLEMQSQQLRESN--QQLDLSACRLTTQCELL------------------- 1231
            L +L+ E  Q   Q Q L+E+   QQ  LS      Q E                     
Sbjct: 2472 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2531

Query: 1232 TQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKL 1291
             QLR  Q+ + +Q+  E Q L     E   R  E+ + + R+Q E L QL   RR++++L
Sbjct: 2532 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE-LQQLEQQRRQQEEL 2590

Query: 1292 V----EKIMDQYRVLE 1303
            +    +++ +Q ++LE
Sbjct: 2591 LAEENQRLREQLQLLE 2606



 Score =  159 bits (401), Expect = 2e-38
 Identities = 300/1197 (25%), Positives = 491/1197 (41%), Gaps = 217/1197 (18%)

Query: 193  DPGELAPAELEMLSR---SLMGTLSKLARERDLGAQ---RLAELLLEREPLCLRPEAPSR 246
            D G   P +  M  R   S      +L +  + GAQ   R    + E + + L+ EA   
Sbjct: 946  DAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACET 1005

Query: 247  APAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALS 306
                   H L L L    A  R   Q + E+ +    +QAEV+GL   + RL  EA    
Sbjct: 1006 RTV----HRLRLPLDKEPA--RECAQRIAEQQK----AQAEVEGLGKGVARLSAEA---- 1051

Query: 307  GQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKS-QLEEERVLSGVLEA 365
                      E+  AL E +   P L+ EL     +L+   +  +  LE+ + +S V+  
Sbjct: 1052 ----------EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1101

Query: 366  SKA------LLEEQLEAARERCARLHETQRENLLLRTRLGEAHAE---LDSLRHQV---- 412
            ++         EEQL+ A+   A L E +     L+    +A A+    D+LR ++    
Sbjct: 1102 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQ 1161

Query: 413  ---DQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENR 469
               ++L + + E ++E++R  E       +      A   Q +VR+      R LE+  R
Sbjct: 1162 EVGERLQQRHGERDVEVERWRE----RVAQLLERWQAVLAQTDVRQ------RELEQLGR 1211

Query: 470  ELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQA 529
            +LR   +                  DP+   L++A +        P    Q  R+   Q 
Sbjct: 1212 QLRYYRE----------------SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE 1255

Query: 530  LDLAPPALDSVLEASAECPQAPDS-----DPQEAESPLQAAAMDPQASDWSPQ--ESGSP 582
              L    ++   E   EC +            E +     A ++P AS       +SGS 
Sbjct: 1256 QALL-EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1314

Query: 583  VETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLR 642
               QE  +     S L +  S         K  +  L   E E R A Q           
Sbjct: 1315 SVIQEYVDLRTHYSELTTLTS------QYIKFISETLRRMEEEERLAEQ----------- 1357

Query: 643  QEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKS 702
            Q   E +      ++++ + Q         A  + EA+E  QR++        ++  ++ 
Sbjct: 1358 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--------EEVVRRE 1409

Query: 703  EGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEA 762
            E A++ Q                ++ +++EE+ QLR+ +EA   E++A+AR+ EA     
Sbjct: 1410 EAAVDAQ---------------QQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSR 1451

Query: 763  ARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAG 822
             R+ +E+   R       R+      E   LR   E A  +   A +E E L   +    
Sbjct: 1452 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1511

Query: 823  RERRQWERE-GSRLRAQSEAAEERMQVLES--EGRQHLEEAERERREKEALQAELEKAVV 879
            + +RQ E E  SR++A++EAA E+ + L++  E R   EEAER  R     QAE+E+A  
Sbjct: 1512 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVERA-- 1564

Query: 880  RGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQ------RLEAELQA---- 929
              +++   LE  QR  E     ++    EK +Q +R    E       R EAE +A    
Sbjct: 1565 --RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1622

Query: 930  -AATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNA 988
             A  ++EEA  EL+   L+  E L +LR     +  +K       E Q     E E    
Sbjct: 1623 EAERAREEAERELERWQLKANEAL-RLRLQAEEVAQQKSLAQAEAEKQKEE-AEREARRR 1680

Query: 989  MLVAEKAALQGQL--QHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQEL 1046
                E+A  Q +L  Q LE Q    +G AQ+ L     A++   RL+AE    E Q Q L
Sbjct: 1681 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL----AAEQELIRLRAETEQGEQQRQLL 1736

Query: 1047 HRKLEVLEEEVRAARQSQEE-------TRGQQQALLRDHKALAQLQRRQEAE-----LEG 1094
              +L  L+ E  AA Q ++E        R + + LL   KA A+ + R  +E     LE 
Sbjct: 1737 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS-KARAEEESRSTSEKSKQRLEA 1795

Query: 1095 LLVRHRDL---KANMRAL-ELAHRELQGRHEQLQAQRASVE---AQEVALLAERERLMQD 1147
               R R+L    A +RAL E A R+ Q   E    QRA  E   A+++A + E  RL  +
Sbjct: 1796 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1855

Query: 1148 GHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGE----RGELRGRLARL------E 1197
                   E  L+  ++E++R + L  + + +R  L+ +    + ++  RLA+L      E
Sbjct: 1856 A------EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1909

Query: 1198 LE------------RAQLEMQSQQLRES-------NQQLDLSACRLTTQCELLTQLRSAQ 1238
            LE            R Q+E +   L+ S         +L+L   R+ +  E    LRS +
Sbjct: 1910 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE--DTLRSKE 1967

Query: 1239 EEE-----NRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQK 1290
            + E      RQL AE +   RE  E +++SL + +   R+++  L+++  L+ + ++
Sbjct: 1968 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2024



 Score =  154 bits (389), Expect = 6e-37
 Identities = 291/1222 (23%), Positives = 499/1222 (40%), Gaps = 233/1222 (19%)

Query: 269  RLRQELEEKAELLLDS---QAEVQGLEAEIRRLRQEAQALSGQAKRAELYREE------- 318
            R+ Q LE    +L  +   Q E++ L  ++R  R+ A  L    + A   +E+       
Sbjct: 1184 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1243

Query: 319  -AEALRERAGRLPRLQEELRRCRERLQAAE------------------AYKSQLE----- 354
             ++A+RE+  +   L EE+ R  E+++  +                   YK+QLE     
Sbjct: 1244 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1303

Query: 355  --EERVLSGVLEASK-------------ALLEEQLEAARERCARLHETQR----ENLLLR 395
              + +V SG     +              L  + ++   E   R+ E +R    +    R
Sbjct: 1304 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1363

Query: 396  TRLGEAHAELDSLRHQVDQLAEENVELE---LELQRSLEPPPGSPGEAPLAGAAP--SLQ 450
             RL E  A L+  R   +  A+   + E    ELQ+ ++       EA +       S+Q
Sbjct: 1364 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1423

Query: 451  DEVRE------------------AEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAP 492
            +E+++                  AE  RLR +E E R +R  L+  + Q GG    L+A 
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQAL 1482

Query: 493  REDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECP---- 548
            R        EEA           + L ++ +D   Q    A   L S ++A AE      
Sbjct: 1483 RAR-----AEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQ 1536

Query: 549  -----------QAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQES--PEKAGRR 595
                       QA +++ +  ++ ++ A     A + + + + + ++++ +   EK  + 
Sbjct: 1537 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1596

Query: 596  SSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEP 655
                    VA  Q      +  Q        RE  + EL  E W L+          +E 
Sbjct: 1597 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL--ERWQLK---------ANEA 1645

Query: 656  SSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGA-----LEVQV 710
              ++L+ +E   Q   LA  +AE ++ +   E   R  A ++  ++ E A      + Q+
Sbjct: 1646 LRLRLQAEEVAQQ-KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1704

Query: 711  WEGPIPGESLA------------SGVAEQEALREEVAQLRRKAEAL---GDELEAQARKL 755
             EG       A             G  +++ L EE+A+L+R+A A      ELEA+  K+
Sbjct: 1705 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1764

Query: 756  EAQ---------NTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQ---- 802
             A+           E    S      +R EAEA R  E  A E ARLR   E A +    
Sbjct: 1765 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQL 1823

Query: 803  -ELESASQEREA---LVEALAAAGRERR----------QWEREGSRLRAQSEAAEERMQV 848
             E ++A Q  EA   L E LAA G   R          + E E  RLR  +E    + + 
Sbjct: 1824 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1883

Query: 849  LESEGRQH-------------------------LEEAERERREKE----ALQAELEKAVV 879
            LE +  QH                         +E+  R+RR+ E    AL+A  EKA  
Sbjct: 1884 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1943

Query: 880  RGKELGARL-------EHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQA--- 929
               EL   L       E   R  EQA LE     +    + +R +  E+R++  L A   
Sbjct: 1944 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2003

Query: 930  AATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAM 989
            AA  ++ AL E++    ++EE   +LR+       ++    Q  E    RL   E+++A 
Sbjct: 2004 AARQRKAALEEVERLKAKVEEAR-RLRERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF 2060

Query: 990  LVAEK-AALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHR 1048
             V +K   LQ  LQ  +  L  L+G A+     ++ A+E  +R+QAE+   + + Q    
Sbjct: 2061 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQSRRQ---- 2114

Query: 1049 KLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRA 1108
                  EE    +QS EE     QA  R     A  + R+EAE E    R +  +A +R 
Sbjct: 2115 -----VEEAERLKQSAEE-----QAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAALRQ 2163

Query: 1109 LELAHRELQGRHEQLQAQRASVEAQ-EVALLAERERLMQDGHRQRGLEEELRRLQSEHDR 1167
             + A  E++ +H++   Q    +AQ E  L   R +L +  H++  L+EEL+RL++E   
Sbjct: 2164 KQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2222

Query: 1168 AQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQS--------QQLRESNQQLDL 1219
            A    +++  E   ++ +  EL    AR+E E   L ++         Q+  E  +Q+  
Sbjct: 2223 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2282

Query: 1220 SACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERS--LESRDHLHREQREY 1277
             A RL+   +   +LR   EE+  Q  A  + + +E  + ++ +  L++   L ++Q+E 
Sbjct: 2283 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2342

Query: 1278 L-DQLNALRREKQKLVEKIMDQ 1298
              +Q   L+ +K+++ +++ ++
Sbjct: 2343 AQEQARRLQEDKEQMAQQLAEE 2364



 Score =  140 bits (353), Expect = 9e-33
 Identities = 259/1088 (23%), Positives = 436/1088 (40%), Gaps = 161/1088 (14%)

Query: 217  ARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEE 276
            A E+ +  + LAE  LE++       A  R  AE     L  +    + Q + L +EL  
Sbjct: 1683 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1742

Query: 277  KAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAE----------LYREEAEA----- 321
                   +  + Q LEAE+ ++R E + L     RAE            R EAEA     
Sbjct: 1743 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1802

Query: 322  LRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVL----EASKALLEEQL--- 374
            L E A RL  L EE +R R+ L   +A + + E ERVL+  L    EA++   E ++   
Sbjct: 1803 LAEEAARLRALAEEAKRQRQ-LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1861

Query: 375  --EAARERCARLHET---QRENLL---------LRTRLGEAHAELDSLRHQVDQLAEENV 420
              EA  ER  RL E    QR  L          +  RL +     DS   +   L E+ +
Sbjct: 1862 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1921

Query: 421  -------ELELELQRSLEPPPGSPGEAPL------AGAAPSLQD-EVREAEAGRLRTL-E 465
                   E  L L+ S E       E  L      + A  +L+  E  E EA R R L  
Sbjct: 1922 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1981

Query: 466  RENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDG 525
             E R  R   + +Q     +    EA R+      LEE  +     + + + L ++A   
Sbjct: 1982 EEERRRREAEERVQKSLAAEE---EAARQRKA--ALEEVERLKAKVEEA-RRLRERAEQE 2035

Query: 526  GPQALDLAPPALDSVLEASAECPQ-APDSDPQEAESPLQAAAMDPQASDWSPQESGSPVE 584
              + L LA  A    L+A  +    A     QE +  LQ    +    D    E+ +   
Sbjct: 2036 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ---QEQSVLDQLRGEAEAARR 2092

Query: 585  TQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQE 644
              E  E+A  ++  ++  S         +++  + L    E +   + +    A  LR+E
Sbjct: 2093 AAEEAEEARVQAEREAAQS-------RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2145

Query: 645  GPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE- 703
              +     ++     L +++            AE  +H +  E T+R    QK Q + E 
Sbjct: 2146 AEQEAARRAQAEQAALRQKQ---------AADAEMEKHKKFAEQTLR----QKAQVEQEL 2192

Query: 704  GALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAE-------ALGDELEAQARKLE 756
              L +Q+ E       L   +   +A   E A+ R + E          +EL     ++E
Sbjct: 2193 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2252

Query: 757  AQN--------TEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESAS 808
            A+N            R  +E A+  +  AE        A E ARLR+  E      E  +
Sbjct: 2253 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLA 2306

Query: 809  QEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEE----AERER 864
            Q+R AL E +    +E+ Q  +E +RL+A++E  +++ ++ + + R+  E+    A++  
Sbjct: 2307 QQR-ALAEKML---KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2362

Query: 865  REKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLE 924
             E +  Q  LE    R  E+ A  E L  +L  A + R +   E+++Q  R Q  E   +
Sbjct: 2363 EETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2420

Query: 925  AELQAAATSKEEALME-LKTRALQLEEELFQLRQGPAGLGPKK------------RAEPQ 971
                  AT ++  L++ L+ +  Q + +  +LR+  A L  +K            ++E  
Sbjct: 2421 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2480

Query: 972  LVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSR 1031
                Q   L E +      ++EK +L  + + +E +   L+   Q+ + ++Q+ +E   R
Sbjct: 2481 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2540

Query: 1032 LQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAE 1091
             Q +        QE  R +  +EE  R   +++E  R +Q+ L +      + QRRQ+ E
Sbjct: 2541 QQQQME------QERQRLVASMEEARRRQHEAEEGVRRKQEELQQ-----LEQQRRQQEE 2589

Query: 1092 LEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRA----------------SVEAQ-E 1134
            L  L   ++ L+  ++ LE  HR      E++ A +                 + EA+ E
Sbjct: 2590 L--LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2647

Query: 1135 VALLAERERLMQDGHRQRGL--EEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGR 1192
             +    R ++     ++ G+   EEL+RL   H      LA     R  LQG R  + G 
Sbjct: 2648 HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE-LARREDVRHYLQG-RSSIAGL 2705

Query: 1193 LARLELER 1200
            L +   E+
Sbjct: 2706 LLKATNEK 2713



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 148/629 (23%), Positives = 255/629 (40%), Gaps = 60/629 (9%)

Query: 716  PGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRA 775
            P    A  +AEQ+  + EV  L +    L  E E +   L   +  A  L  EL +    
Sbjct: 1019 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE-KVLALPEPSPAAPTLRSEL-ELTLG 1076

Query: 776  EAEAHREAEAQAWEQARLREAV---EAAGQELESASQEREALVEALAAAGRERRQWEREG 832
            + E  R   A   E+ +    V       +E+  A +E+    +A+ A   E    +   
Sbjct: 1077 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1136

Query: 833  SRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQ 892
             +LRAQ+EA +     L  E R   E  ER ++       E+E+   R  +L   LE  Q
Sbjct: 1137 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQ 1193

Query: 893  RELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEEL 952
              L Q  + RQ  L +   Q + Y+     L A LQ  A  ++E +  +     Q   E 
Sbjct: 1194 AVLAQTDV-RQRELEQLGRQLRYYRESADPLGAWLQ-DARRRQEQIQAMPLADSQAVRE- 1250

Query: 953  FQLRQGPAGLGPKKRAEPQLVETQNVR---LIEVERSNAMLVAEKAALQGQLQHLEGQLG 1009
             QLRQ  A L   +R   ++ E Q      +  ++     LV  KA L+        +  
Sbjct: 1251 -QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS--PAKKP 1307

Query: 1010 SLQGRAQELLLQSQRAQEHSSRLQAEKS-VLEIQGQELHRKLEVLEEEVRAARQSQEETR 1068
             +Q  ++ ++ +    + H S L    S  ++   + L R    +EEE R A Q + E R
Sbjct: 1308 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR----MEEEERLAEQQRAEER 1363

Query: 1069 ---GQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQA 1125
                + +A L   + LA+   + +A+ E      ++L+  M+  E+  RE      Q Q 
Sbjct: 1364 ERLAEVEAALEKQRQLAEAHAQAKAQAER---EAKELQQRMQE-EVVRREEAAVDAQQQK 1419

Query: 1126 QRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGE 1185
            +    E Q++   +E E +     +    E    R++ E    ++ L    R+RG  +GE
Sbjct: 1420 RSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1478

Query: 1186 RGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQL 1245
               LR R    E ++ Q + ++++LR                       R  Q+E  R+ 
Sbjct: 1479 LQALRARAEEAEAQKRQAQEEAERLR-----------------------RQVQDESQRKR 1515

Query: 1246 LAEVQALSRENREL-----LERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYR 1300
             AEV+  SR   E       +R+L++ + L  +  E   +L     E+ + V+  ++  +
Sbjct: 1516 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1575

Query: 1301 VLEPVPLPRTKKGSWLADKVKRLMRPRRE 1329
                  L ++K+ S+ A+K  +L R  +E
Sbjct: 1576 RSAEAEL-QSKRASF-AEKTAQLERSLQE 1602



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 131/567 (23%), Positives = 217/567 (38%), Gaps = 69/567 (12%)

Query: 694  AW-QKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAE-ALGDELEAQ 751
            AW ++ Q + +GA     W   +P  S+ + +     L + + + R K E A  DE +  
Sbjct: 534  AWVEENQHRVDGA----EWGVDLP--SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS 587

Query: 752  ARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQER 811
                 A      RL  + A+   +     R  E+       L   V AA +EL   +++ 
Sbjct: 588  PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES-------LHSFVAAATKELMWLNEKE 640

Query: 812  EALVEALAAAGRERRQWEREG-SRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEAL 870
            E  V    +        ++E  S L  + E  E++++ L++ G + L E    R   E+ 
Sbjct: 641  EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 700

Query: 871  QAELEKAVVRGKELGARLEHLQRELEQAALERQEF--LREKESQHQRYQ-GLEQRLEAEL 927
            QA L+       +L   +E     L++ A   Q F  +RE E Q Q+ Q  L ++   + 
Sbjct: 701  QAALQTQWSWMLQLCCCIE---AHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 757

Query: 928  QAAATSKEEALMELKTRALQLEEE------LFQLRQGPAGLGPKKRAEPQ-----LVETQ 976
             A  T  E+ L + +    QL E       L +  +    L P+  A P      L+   
Sbjct: 758  SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC 817

Query: 977  NVRLIEV---ERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQ 1033
            + + +EV   +     LV        ++    G   ++      +   +Q AQE  +RL+
Sbjct: 818  DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE 877

Query: 1034 AEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELE 1093
            A+   L     +LH  ++ L                  Q+L RD     QL R       
Sbjct: 878  AQHQALVTLWHQLHVDMKSLL---------------AWQSLRRD----VQLIRSWS---- 914

Query: 1094 GLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRG 1153
              L   R LK   +   L   EL  +     +Q A     E  L+AERE      H Q+ 
Sbjct: 915  --LATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQ- 971

Query: 1154 LEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELER------AQLEMQS 1207
            L + L +   E  R Q  ++EL   R +L+        RL RL L++      AQ   + 
Sbjct: 972  LLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL-RLPLDKEPARECAQRIAEQ 1030

Query: 1208 QQLRESNQQLDLSACRLTTQCELLTQL 1234
            Q+ +   + L     RL+ + E +  L
Sbjct: 1031 QKAQAEVEGLGKGVARLSAEAEKVLAL 1057


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  199 bits (505), Expect = 2e-50
 Identities = 333/1276 (26%), Positives = 533/1276 (41%), Gaps = 170/1276 (13%)

Query: 106  QEELQLLILSPPPDLQTLGFDPLSEEA----VEQLEGVLRLLLGASVQCEHRELFIRHIQ 161
            QEELQ L  S   ++Q       + E     +E+   V+RL L A+     R+      +
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT----ERQRGGAEGE 1474

Query: 162  GLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARERD 221
              +L  ++E A A +   Q  A  +      +      AE+E+ SR  +   ++ ARE+ 
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR--VKAEAEAAREKQ 1532

Query: 222  LGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELL 281
               Q L EL L+ E    R        A      L     +A+A+L+  R    EK   L
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592

Query: 282  LDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRER-------AGRLPRLQE 334
               +  +Q     + +LR+EA+  + Q   AE  REEAE   ER       A RL    E
Sbjct: 1593 ---ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649

Query: 335  ELRRCRERLQA-AEAYKSQLEEERVLSGVLEAS----KALLEEQLE--------AARERC 381
            E+ + +   QA AE  K + E E    G  E      + L E++LE         A++R 
Sbjct: 1650 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1709

Query: 382  ARLHETQRENLLLRTRLGEAHA-----ELDSLRHQVDQLAEENVELELELQR---SLEPP 433
            A   E  R  L   T  GE        EL  L+ +     ++  ELE EL +    +E  
Sbjct: 1710 AAEQELIR--LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1767

Query: 434  PGSPGEAPLAGAAPSLQDEVR-EAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAP 492
              S   A     + S + + R EAEAGR R L  E   LR L +             EA 
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE-------------EAK 1814

Query: 493  REDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPD 552
            R+  +    E+A +       + + L +K    G +A  L   A  ++ E  AE  +   
Sbjct: 1815 RQRQLAE--EDAARQRA---EAERVLAEKLAAIG-EATRLKTEAEIALKEKEAENERLRR 1868

Query: 553  SDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGT 612
                EA    Q   ++ QA+     +  + +E + +  +    S L+    +        
Sbjct: 1869 LAEDEA---FQRRRLEEQAA-----QHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920

Query: 613  KIQAPQLLGGETEGREAPQG--ELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGL 670
            +    ++L  +    +A  G  EL  E   +R    +         S +  E E   Q  
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL------RSKEQAELEAARQRQ 1974

Query: 671  DLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE----GALEVQVWEGPIPGESLASGVAE 726
              A  +   RE ++R++ ++        Q+K+       L+ +V E     E      A 
Sbjct: 1975 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2034

Query: 727  QEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAA------RLSKELAQARRAEAEAH 780
            Q  L +E AQ R +AE        Q ++ E Q T         +L  E   ARRA  EA 
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA- 2093

Query: 781  REAEAQA-WEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQS 839
             EA  QA  E A+ R  VE A +  +SA ++ +A  +A AAA + R++ E+E +R     
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153

Query: 840  EAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAA 899
            +AA  + Q  ++E  +H + AE+  R+K  ++ EL    ++ +E   +   L  EL++  
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213

Query: 900  LERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGP 959
             E  E  R      QR Q  E+     +Q    SK +A +E + RAL L +         
Sbjct: 2214 AEATEAAR------QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD--------- 2258

Query: 960  AGLGPKKRAEPQL-VETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQEL 1018
                 K   +  L  E + ++ +  E +   + A++AA   QL   E  L   +  A+++
Sbjct: 2259 -----KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL--AEEDLAQQRALAEKM 2311

Query: 1019 LLQSQRAQEHSSRLQAEKSVLEIQ---GQELHRKLEVLEEEVRAARQSQEETRGQQQALL 1075
            L +  +A + ++RL+AE  +L+ Q    QE  R+L+  E++ + A+Q  EET+G Q+ L 
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ--EDKEQMAQQLAEETQGFQRTL- 2368

Query: 1076 RDHKALAQLQRRQEAELEGLLVRHRDL-KANMRALELAHRELQGRHEQLQAQRASVEAQE 1134
               +A  Q Q    AE E L +R  ++ +A  RA E              AQR   +A+E
Sbjct: 2369 ---EAERQRQLEMSAEAERLKLRVAEMSRAQARAEE-------------DAQRFRKQAEE 2412

Query: 1135 VALLAERERLMQDGHRQRGLEEELRRLQSEHD--RAQMLLAELSRERGELQGERGELRGR 1192
            +     R  L            E++R QS+HD  R +  +AEL RE+ +LQ E      +
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE-----AK 2467

Query: 1193 LARLELERAQLEMQSQQLRESN--QQLDLSACRLTTQCELL------------------- 1231
            L +L+ E  Q   Q Q L+E+   QQ  LS      Q E                     
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527

Query: 1232 TQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKL 1291
             QLR  Q+ + +Q+  E Q L     E   R  E+ + + R+Q E L QL   RR++++L
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE-LQQLEQQRRQQEEL 2586

Query: 1292 V----EKIMDQYRVLE 1303
            +    +++ +Q ++LE
Sbjct: 2587 LAEENQRLREQLQLLE 2602



 Score =  159 bits (401), Expect = 2e-38
 Identities = 300/1197 (25%), Positives = 491/1197 (41%), Gaps = 217/1197 (18%)

Query: 193  DPGELAPAELEMLSR---SLMGTLSKLARERDLGAQ---RLAELLLEREPLCLRPEAPSR 246
            D G   P +  M  R   S      +L +  + GAQ   R    + E + + L+ EA   
Sbjct: 942  DAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACET 1001

Query: 247  APAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALS 306
                   H L L L    A  R   Q + E+ +    +QAEV+GL   + RL  EA    
Sbjct: 1002 RTV----HRLRLPLDKEPA--RECAQRIAEQQK----AQAEVEGLGKGVARLSAEA---- 1047

Query: 307  GQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKS-QLEEERVLSGVLEA 365
                      E+  AL E +   P L+ EL     +L+   +  +  LE+ + +S V+  
Sbjct: 1048 ----------EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1097

Query: 366  SKA------LLEEQLEAARERCARLHETQRENLLLRTRLGEAHAE---LDSLRHQV---- 412
            ++         EEQL+ A+   A L E +     L+    +A A+    D+LR ++    
Sbjct: 1098 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQ 1157

Query: 413  ---DQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENR 469
               ++L + + E ++E++R  E       +      A   Q +VR+      R LE+  R
Sbjct: 1158 EVGERLQQRHGERDVEVERWRE----RVAQLLERWQAVLAQTDVRQ------RELEQLGR 1207

Query: 470  ELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQA 529
            +LR   +                  DP+   L++A +        P    Q  R+   Q 
Sbjct: 1208 QLRYYRE----------------SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE 1251

Query: 530  LDLAPPALDSVLEASAECPQAPDS-----DPQEAESPLQAAAMDPQASDWSPQ--ESGSP 582
              L    ++   E   EC +            E +     A ++P AS       +SGS 
Sbjct: 1252 QALL-EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1310

Query: 583  VETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLR 642
               QE  +     S L +  S         K  +  L   E E R A Q           
Sbjct: 1311 SVIQEYVDLRTHYSELTTLTS------QYIKFISETLRRMEEEERLAEQ----------- 1353

Query: 643  QEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKS 702
            Q   E +      ++++ + Q         A  + EA+E  QR++        ++  ++ 
Sbjct: 1354 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--------EEVVRRE 1405

Query: 703  EGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEA 762
            E A++ Q                ++ +++EE+ QLR+ +EA   E++A+AR+ EA     
Sbjct: 1406 EAAVDAQ---------------QQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSR 1447

Query: 763  ARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAG 822
             R+ +E+   R       R+      E   LR   E A  +   A +E E L   +    
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507

Query: 823  RERRQWERE-GSRLRAQSEAAEERMQVLES--EGRQHLEEAERERREKEALQAELEKAVV 879
            + +RQ E E  SR++A++EAA E+ + L++  E R   EEAER  R     QAE+E+A  
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVERA-- 1560

Query: 880  RGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQ------RLEAELQA---- 929
              +++   LE  QR  E     ++    EK +Q +R    E       R EAE +A    
Sbjct: 1561 --RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1618

Query: 930  -AATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNA 988
             A  ++EEA  EL+   L+  E L +LR     +  +K       E Q     E E    
Sbjct: 1619 EAERAREEAERELERWQLKANEAL-RLRLQAEEVAQQKSLAQAEAEKQKEE-AEREARRR 1676

Query: 989  MLVAEKAALQGQL--QHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQEL 1046
                E+A  Q +L  Q LE Q    +G AQ+ L     A++   RL+AE    E Q Q L
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL----AAEQELIRLRAETEQGEQQRQLL 1732

Query: 1047 HRKLEVLEEEVRAARQSQEE-------TRGQQQALLRDHKALAQLQRRQEAE-----LEG 1094
              +L  L+ E  AA Q ++E        R + + LL   KA A+ + R  +E     LE 
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS-KARAEEESRSTSEKSKQRLEA 1791

Query: 1095 LLVRHRDL---KANMRAL-ELAHRELQGRHEQLQAQRASVE---AQEVALLAERERLMQD 1147
               R R+L    A +RAL E A R+ Q   E    QRA  E   A+++A + E  RL  +
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851

Query: 1148 GHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGE----RGELRGRLARL------E 1197
                   E  L+  ++E++R + L  + + +R  L+ +    + ++  RLA+L      E
Sbjct: 1852 A------EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1905

Query: 1198 LE------------RAQLEMQSQQLRES-------NQQLDLSACRLTTQCELLTQLRSAQ 1238
            LE            R Q+E +   L+ S         +L+L   R+ +  E    LRS +
Sbjct: 1906 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE--DTLRSKE 1963

Query: 1239 EEE-----NRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQK 1290
            + E      RQL AE +   RE  E +++SL + +   R+++  L+++  L+ + ++
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020



 Score =  154 bits (389), Expect = 6e-37
 Identities = 291/1222 (23%), Positives = 499/1222 (40%), Gaps = 233/1222 (19%)

Query: 269  RLRQELEEKAELLLDS---QAEVQGLEAEIRRLRQEAQALSGQAKRAELYREE------- 318
            R+ Q LE    +L  +   Q E++ L  ++R  R+ A  L    + A   +E+       
Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1239

Query: 319  -AEALRERAGRLPRLQEELRRCRERLQAAE------------------AYKSQLE----- 354
             ++A+RE+  +   L EE+ R  E+++  +                   YK+QLE     
Sbjct: 1240 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1299

Query: 355  --EERVLSGVLEASK-------------ALLEEQLEAARERCARLHETQR----ENLLLR 395
              + +V SG     +              L  + ++   E   R+ E +R    +    R
Sbjct: 1300 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359

Query: 396  TRLGEAHAELDSLRHQVDQLAEENVELE---LELQRSLEPPPGSPGEAPLAGAAP--SLQ 450
             RL E  A L+  R   +  A+   + E    ELQ+ ++       EA +       S+Q
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419

Query: 451  DEVRE------------------AEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAP 492
            +E+++                  AE  RLR +E E R +R  L+  + Q GG    L+A 
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQAL 1478

Query: 493  REDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECP---- 548
            R        EEA           + L ++ +D   Q    A   L S ++A AE      
Sbjct: 1479 RAR-----AEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQ 1532

Query: 549  -----------QAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQES--PEKAGRR 595
                       QA +++ +  ++ ++ A     A + + + + + ++++ +   EK  + 
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592

Query: 596  SSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEP 655
                    VA  Q      +  Q        RE  + EL  E W L+          +E 
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL--ERWQLK---------ANEA 1641

Query: 656  SSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGA-----LEVQV 710
              ++L+ +E   Q   LA  +AE ++ +   E   R  A ++  ++ E A      + Q+
Sbjct: 1642 LRLRLQAEEVAQQ-KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1700

Query: 711  WEGPIPGESLA------------SGVAEQEALREEVAQLRRKAEAL---GDELEAQARKL 755
             EG       A             G  +++ L EE+A+L+R+A A      ELEA+  K+
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760

Query: 756  EAQ---------NTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQ---- 802
             A+           E    S      +R EAEA R  E  A E ARLR   E A +    
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQL 1819

Query: 803  -ELESASQEREA---LVEALAAAGRERR----------QWEREGSRLRAQSEAAEERMQV 848
             E ++A Q  EA   L E LAA G   R          + E E  RLR  +E    + + 
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1879

Query: 849  LESEGRQH-------------------------LEEAERERREKE----ALQAELEKAVV 879
            LE +  QH                         +E+  R+RR+ E    AL+A  EKA  
Sbjct: 1880 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1939

Query: 880  RGKELGARL-------EHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQA--- 929
               EL   L       E   R  EQA LE     +    + +R +  E+R++  L A   
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999

Query: 930  AATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAM 989
            AA  ++ AL E++    ++EE   +LR+       ++    Q  E    RL   E+++A 
Sbjct: 2000 AARQRKAALEEVERLKAKVEEAR-RLRERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF 2056

Query: 990  LVAEK-AALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHR 1048
             V +K   LQ  LQ  +  L  L+G A+     ++ A+E  +R+QAE+   + + Q    
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQSRRQ---- 2110

Query: 1049 KLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRA 1108
                  EE    +QS EE     QA  R     A  + R+EAE E    R +  +A +R 
Sbjct: 2111 -----VEEAERLKQSAEE-----QAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAALRQ 2159

Query: 1109 LELAHRELQGRHEQLQAQRASVEAQ-EVALLAERERLMQDGHRQRGLEEELRRLQSEHDR 1167
             + A  E++ +H++   Q    +AQ E  L   R +L +  H++  L+EEL+RL++E   
Sbjct: 2160 KQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218

Query: 1168 AQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQS--------QQLRESNQQLDL 1219
            A    +++  E   ++ +  EL    AR+E E   L ++         Q+  E  +Q+  
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278

Query: 1220 SACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERS--LESRDHLHREQREY 1277
             A RL+   +   +LR   EE+  Q  A  + + +E  + ++ +  L++   L ++Q+E 
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2338

Query: 1278 L-DQLNALRREKQKLVEKIMDQ 1298
              +Q   L+ +K+++ +++ ++
Sbjct: 2339 AQEQARRLQEDKEQMAQQLAEE 2360



 Score =  140 bits (353), Expect = 9e-33
 Identities = 259/1088 (23%), Positives = 436/1088 (40%), Gaps = 161/1088 (14%)

Query: 217  ARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEE 276
            A E+ +  + LAE  LE++       A  R  AE     L  +    + Q + L +EL  
Sbjct: 1679 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1738

Query: 277  KAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAE----------LYREEAEA----- 321
                   +  + Q LEAE+ ++R E + L     RAE            R EAEA     
Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798

Query: 322  LRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVL----EASKALLEEQL--- 374
            L E A RL  L EE +R R+ L   +A + + E ERVL+  L    EA++   E ++   
Sbjct: 1799 LAEEAARLRALAEEAKRQRQ-LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857

Query: 375  --EAARERCARLHET---QRENLL---------LRTRLGEAHAELDSLRHQVDQLAEENV 420
              EA  ER  RL E    QR  L          +  RL +     DS   +   L E+ +
Sbjct: 1858 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1917

Query: 421  -------ELELELQRSLEPPPGSPGEAPL------AGAAPSLQD-EVREAEAGRLRTL-E 465
                   E  L L+ S E       E  L      + A  +L+  E  E EA R R L  
Sbjct: 1918 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1977

Query: 466  RENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDG 525
             E R  R   + +Q     +    EA R+      LEE  +     + + + L ++A   
Sbjct: 1978 EEERRRREAEERVQKSLAAEE---EAARQRKA--ALEEVERLKAKVEEA-RRLRERAEQE 2031

Query: 526  GPQALDLAPPALDSVLEASAECPQ-APDSDPQEAESPLQAAAMDPQASDWSPQESGSPVE 584
              + L LA  A    L+A  +    A     QE +  LQ    +    D    E+ +   
Sbjct: 2032 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ---QEQSVLDQLRGEAEAARR 2088

Query: 585  TQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQE 644
              E  E+A  ++  ++  S         +++  + L    E +   + +    A  LR+E
Sbjct: 2089 AAEEAEEARVQAEREAAQS-------RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141

Query: 645  GPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE- 703
              +     ++     L +++            AE  +H +  E T+R    QK Q + E 
Sbjct: 2142 AEQEAARRAQAEQAALRQKQ---------AADAEMEKHKKFAEQTLR----QKAQVEQEL 2188

Query: 704  GALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAE-------ALGDELEAQARKLE 756
              L +Q+ E       L   +   +A   E A+ R + E          +EL     ++E
Sbjct: 2189 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2248

Query: 757  AQN--------TEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESAS 808
            A+N            R  +E A+  +  AE        A E ARLR+  E      E  +
Sbjct: 2249 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLA 2302

Query: 809  QEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEE----AERER 864
            Q+R AL E +    +E+ Q  +E +RL+A++E  +++ ++ + + R+  E+    A++  
Sbjct: 2303 QQR-ALAEKML---KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358

Query: 865  REKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLE 924
             E +  Q  LE    R  E+ A  E L  +L  A + R +   E+++Q  R Q  E   +
Sbjct: 2359 EETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2416

Query: 925  AELQAAATSKEEALME-LKTRALQLEEELFQLRQGPAGLGPKK------------RAEPQ 971
                  AT ++  L++ L+ +  Q + +  +LR+  A L  +K            ++E  
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476

Query: 972  LVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSR 1031
                Q   L E +      ++EK +L  + + +E +   L+   Q+ + ++Q+ +E   R
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536

Query: 1032 LQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAE 1091
             Q +        QE  R +  +EE  R   +++E  R +Q+ L +      + QRRQ+ E
Sbjct: 2537 QQQQME------QERQRLVASMEEARRRQHEAEEGVRRKQEELQQ-----LEQQRRQQEE 2585

Query: 1092 LEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRA----------------SVEAQ-E 1134
            L  L   ++ L+  ++ LE  HR      E++ A +                 + EA+ E
Sbjct: 2586 L--LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2643

Query: 1135 VALLAERERLMQDGHRQRGL--EEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGR 1192
             +    R ++     ++ G+   EEL+RL   H      LA     R  LQG R  + G 
Sbjct: 2644 HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE-LARREDVRHYLQG-RSSIAGL 2701

Query: 1193 LARLELER 1200
            L +   E+
Sbjct: 2702 LLKATNEK 2709



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 148/629 (23%), Positives = 255/629 (40%), Gaps = 60/629 (9%)

Query: 716  PGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRA 775
            P    A  +AEQ+  + EV  L +    L  E E +   L   +  A  L  EL +    
Sbjct: 1015 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE-KVLALPEPSPAAPTLRSEL-ELTLG 1072

Query: 776  EAEAHREAEAQAWEQARLREAV---EAAGQELESASQEREALVEALAAAGRERRQWEREG 832
            + E  R   A   E+ +    V       +E+  A +E+    +A+ A   E    +   
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1132

Query: 833  SRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQ 892
             +LRAQ+EA +     L  E R   E  ER ++       E+E+   R  +L   LE  Q
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQ 1189

Query: 893  RELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEEL 952
              L Q  + RQ  L +   Q + Y+     L A LQ  A  ++E +  +     Q   E 
Sbjct: 1190 AVLAQTDV-RQRELEQLGRQLRYYRESADPLGAWLQ-DARRRQEQIQAMPLADSQAVRE- 1246

Query: 953  FQLRQGPAGLGPKKRAEPQLVETQNVR---LIEVERSNAMLVAEKAALQGQLQHLEGQLG 1009
             QLRQ  A L   +R   ++ E Q      +  ++     LV  KA L+        +  
Sbjct: 1247 -QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS--PAKKP 1303

Query: 1010 SLQGRAQELLLQSQRAQEHSSRLQAEKS-VLEIQGQELHRKLEVLEEEVRAARQSQEETR 1068
             +Q  ++ ++ +    + H S L    S  ++   + L R    +EEE R A Q + E R
Sbjct: 1304 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR----MEEEERLAEQQRAEER 1359

Query: 1069 ---GQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQA 1125
                + +A L   + LA+   + +A+ E      ++L+  M+  E+  RE      Q Q 
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAER---EAKELQQRMQE-EVVRREEAAVDAQQQK 1415

Query: 1126 QRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGE 1185
            +    E Q++   +E E +     +    E    R++ E    ++ L    R+RG  +GE
Sbjct: 1416 RSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474

Query: 1186 RGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQL 1245
               LR R    E ++ Q + ++++LR                       R  Q+E  R+ 
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLR-----------------------RQVQDESQRKR 1511

Query: 1246 LAEVQALSRENREL-----LERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYR 1300
             AEV+  SR   E       +R+L++ + L  +  E   +L     E+ + V+  ++  +
Sbjct: 1512 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1571

Query: 1301 VLEPVPLPRTKKGSWLADKVKRLMRPRRE 1329
                  L ++K+ S+ A+K  +L R  +E
Sbjct: 1572 RSAEAEL-QSKRASF-AEKTAQLERSLQE 1598



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 131/567 (23%), Positives = 217/567 (38%), Gaps = 69/567 (12%)

Query: 694  AW-QKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAE-ALGDELEAQ 751
            AW ++ Q + +GA     W   +P  S+ + +     L + + + R K E A  DE +  
Sbjct: 530  AWVEENQHRVDGA----EWGVDLP--SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS 583

Query: 752  ARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQER 811
                 A      RL  + A+   +     R  E+       L   V AA +EL   +++ 
Sbjct: 584  PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES-------LHSFVAAATKELMWLNEKE 636

Query: 812  EALVEALAAAGRERRQWEREG-SRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEAL 870
            E  V    +        ++E  S L  + E  E++++ L++ G + L E    R   E+ 
Sbjct: 637  EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 696

Query: 871  QAELEKAVVRGKELGARLEHLQRELEQAALERQEF--LREKESQHQRYQ-GLEQRLEAEL 927
            QA L+       +L   +E     L++ A   Q F  +RE E Q Q+ Q  L ++   + 
Sbjct: 697  QAALQTQWSWMLQLCCCIE---AHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 753

Query: 928  QAAATSKEEALMELKTRALQLEEE------LFQLRQGPAGLGPKKRAEPQ-----LVETQ 976
             A  T  E+ L + +    QL E       L +  +    L P+  A P      L+   
Sbjct: 754  SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC 813

Query: 977  NVRLIEV---ERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQ 1033
            + + +EV   +     LV        ++    G   ++      +   +Q AQE  +RL+
Sbjct: 814  DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE 873

Query: 1034 AEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELE 1093
            A+   L     +LH  ++ L                  Q+L RD     QL R       
Sbjct: 874  AQHQALVTLWHQLHVDMKSLL---------------AWQSLRRD----VQLIRSWS---- 910

Query: 1094 GLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRG 1153
              L   R LK   +   L   EL  +     +Q A     E  L+AERE      H Q+ 
Sbjct: 911  --LATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQ- 967

Query: 1154 LEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELER------AQLEMQS 1207
            L + L +   E  R Q  ++EL   R +L+        RL RL L++      AQ   + 
Sbjct: 968  LLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL-RLPLDKEPARECAQRIAEQ 1026

Query: 1208 QQLRESNQQLDLSACRLTTQCELLTQL 1234
            Q+ +   + L     RL+ + E +  L
Sbjct: 1027 QKAQAEVEGLGKGVARLSAEAEKVLAL 1053


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  199 bits (505), Expect = 2e-50
 Identities = 333/1276 (26%), Positives = 533/1276 (41%), Gaps = 170/1276 (13%)

Query: 106  QEELQLLILSPPPDLQTLGFDPLSEEA----VEQLEGVLRLLLGASVQCEHRELFIRHIQ 161
            QEELQ L  S   ++Q       + E     +E+   V+RL L A+     R+      +
Sbjct: 1387 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT----ERQRGGAEGE 1442

Query: 162  GLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARERD 221
              +L  ++E A A +   Q  A  +      +      AE+E+ SR  +   ++ ARE+ 
Sbjct: 1443 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR--VKAEAEAAREKQ 1500

Query: 222  LGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELL 281
               Q L EL L+ E    R        A      L     +A+A+L+  R    EK   L
Sbjct: 1501 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1560

Query: 282  LDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRER-------AGRLPRLQE 334
               +  +Q     + +LR+EA+  + Q   AE  REEAE   ER       A RL    E
Sbjct: 1561 ---ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1617

Query: 335  ELRRCRERLQA-AEAYKSQLEEERVLSGVLEAS----KALLEEQLE--------AARERC 381
            E+ + +   QA AE  K + E E    G  E      + L E++LE         A++R 
Sbjct: 1618 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1677

Query: 382  ARLHETQRENLLLRTRLGEAHA-----ELDSLRHQVDQLAEENVELELELQR---SLEPP 433
            A   E  R  L   T  GE        EL  L+ +     ++  ELE EL +    +E  
Sbjct: 1678 AAEQELIR--LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1735

Query: 434  PGSPGEAPLAGAAPSLQDEVR-EAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAP 492
              S   A     + S + + R EAEAGR R L  E   LR L +             EA 
Sbjct: 1736 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE-------------EAK 1782

Query: 493  REDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPD 552
            R+  +    E+A +       + + L +K    G +A  L   A  ++ E  AE  +   
Sbjct: 1783 RQRQLAE--EDAARQRA---EAERVLAEKLAAIG-EATRLKTEAEIALKEKEAENERLRR 1836

Query: 553  SDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGT 612
                EA    Q   ++ QA+     +  + +E + +  +    S L+    +        
Sbjct: 1837 LAEDEA---FQRRRLEEQAA-----QHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1888

Query: 613  KIQAPQLLGGETEGREAPQG--ELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGL 670
            +    ++L  +    +A  G  EL  E   +R    +         S +  E E   Q  
Sbjct: 1889 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL------RSKEQAELEAARQRQ 1942

Query: 671  DLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE----GALEVQVWEGPIPGESLASGVAE 726
              A  +   RE ++R++ ++        Q+K+       L+ +V E     E      A 
Sbjct: 1943 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2002

Query: 727  QEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAA------RLSKELAQARRAEAEAH 780
            Q  L +E AQ R +AE        Q ++ E Q T         +L  E   ARRA  EA 
Sbjct: 2003 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA- 2061

Query: 781  REAEAQA-WEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQS 839
             EA  QA  E A+ R  VE A +  +SA ++ +A  +A AAA + R++ E+E +R     
Sbjct: 2062 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2121

Query: 840  EAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAA 899
            +AA  + Q  ++E  +H + AE+  R+K  ++ EL    ++ +E   +   L  EL++  
Sbjct: 2122 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2181

Query: 900  LERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGP 959
             E  E  R      QR Q  E+     +Q    SK +A +E + RAL L +         
Sbjct: 2182 AEATEAAR------QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD--------- 2226

Query: 960  AGLGPKKRAEPQL-VETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQEL 1018
                 K   +  L  E + ++ +  E +   + A++AA   QL   E  L   +  A+++
Sbjct: 2227 -----KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL--AEEDLAQQRALAEKM 2279

Query: 1019 LLQSQRAQEHSSRLQAEKSVLEIQ---GQELHRKLEVLEEEVRAARQSQEETRGQQQALL 1075
            L +  +A + ++RL+AE  +L+ Q    QE  R+L+  E++ + A+Q  EET+G Q+ L 
Sbjct: 2280 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ--EDKEQMAQQLAEETQGFQRTL- 2336

Query: 1076 RDHKALAQLQRRQEAELEGLLVRHRDL-KANMRALELAHRELQGRHEQLQAQRASVEAQE 1134
               +A  Q Q    AE E L +R  ++ +A  RA E              AQR   +A+E
Sbjct: 2337 ---EAERQRQLEMSAEAERLKLRVAEMSRAQARAEE-------------DAQRFRKQAEE 2380

Query: 1135 VALLAERERLMQDGHRQRGLEEELRRLQSEHD--RAQMLLAELSRERGELQGERGELRGR 1192
            +     R  L            E++R QS+HD  R +  +AEL RE+ +LQ E      +
Sbjct: 2381 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE-----AK 2435

Query: 1193 LARLELERAQLEMQSQQLRESN--QQLDLSACRLTTQCELL------------------- 1231
            L +L+ E  Q   Q Q L+E+   QQ  LS      Q E                     
Sbjct: 2436 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2495

Query: 1232 TQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKL 1291
             QLR  Q+ + +Q+  E Q L     E   R  E+ + + R+Q E L QL   RR++++L
Sbjct: 2496 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE-LQQLEQQRRQQEEL 2554

Query: 1292 V----EKIMDQYRVLE 1303
            +    +++ +Q ++LE
Sbjct: 2555 LAEENQRLREQLQLLE 2570



 Score =  159 bits (401), Expect = 2e-38
 Identities = 300/1197 (25%), Positives = 491/1197 (41%), Gaps = 217/1197 (18%)

Query: 193  DPGELAPAELEMLSR---SLMGTLSKLARERDLGAQ---RLAELLLEREPLCLRPEAPSR 246
            D G   P +  M  R   S      +L +  + GAQ   R    + E + + L+ EA   
Sbjct: 910  DAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACET 969

Query: 247  APAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALS 306
                   H L L L    A  R   Q + E+ +    +QAEV+GL   + RL  EA    
Sbjct: 970  RTV----HRLRLPLDKEPA--RECAQRIAEQQK----AQAEVEGLGKGVARLSAEA---- 1015

Query: 307  GQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKS-QLEEERVLSGVLEA 365
                      E+  AL E +   P L+ EL     +L+   +  +  LE+ + +S V+  
Sbjct: 1016 ----------EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1065

Query: 366  SKA------LLEEQLEAARERCARLHETQRENLLLRTRLGEAHAE---LDSLRHQV---- 412
            ++         EEQL+ A+   A L E +     L+    +A A+    D+LR ++    
Sbjct: 1066 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQ 1125

Query: 413  ---DQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENR 469
               ++L + + E ++E++R  E       +      A   Q +VR+      R LE+  R
Sbjct: 1126 EVGERLQQRHGERDVEVERWRE----RVAQLLERWQAVLAQTDVRQ------RELEQLGR 1175

Query: 470  ELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQA 529
            +LR   +                  DP+   L++A +        P    Q  R+   Q 
Sbjct: 1176 QLRYYRE----------------SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE 1219

Query: 530  LDLAPPALDSVLEASAECPQAPDS-----DPQEAESPLQAAAMDPQASDWSPQ--ESGSP 582
              L    ++   E   EC +            E +     A ++P AS       +SGS 
Sbjct: 1220 QALL-EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1278

Query: 583  VETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLR 642
               QE  +     S L +  S         K  +  L   E E R A Q           
Sbjct: 1279 SVIQEYVDLRTHYSELTTLTS------QYIKFISETLRRMEEEERLAEQ----------- 1321

Query: 643  QEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKS 702
            Q   E +      ++++ + Q         A  + EA+E  QR++        ++  ++ 
Sbjct: 1322 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--------EEVVRRE 1373

Query: 703  EGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEA 762
            E A++ Q                ++ +++EE+ QLR+ +EA   E++A+AR+ EA     
Sbjct: 1374 EAAVDAQ---------------QQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSR 1415

Query: 763  ARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAG 822
             R+ +E+   R       R+      E   LR   E A  +   A +E E L   +    
Sbjct: 1416 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1475

Query: 823  RERRQWERE-GSRLRAQSEAAEERMQVLES--EGRQHLEEAERERREKEALQAELEKAVV 879
            + +RQ E E  SR++A++EAA E+ + L++  E R   EEAER  R     QAE+E+A  
Sbjct: 1476 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVERA-- 1528

Query: 880  RGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQ------RLEAELQA---- 929
              +++   LE  QR  E     ++    EK +Q +R    E       R EAE +A    
Sbjct: 1529 --RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1586

Query: 930  -AATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNA 988
             A  ++EEA  EL+   L+  E L +LR     +  +K       E Q     E E    
Sbjct: 1587 EAERAREEAERELERWQLKANEAL-RLRLQAEEVAQQKSLAQAEAEKQKEE-AEREARRR 1644

Query: 989  MLVAEKAALQGQL--QHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQEL 1046
                E+A  Q +L  Q LE Q    +G AQ+ L     A++   RL+AE    E Q Q L
Sbjct: 1645 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL----AAEQELIRLRAETEQGEQQRQLL 1700

Query: 1047 HRKLEVLEEEVRAARQSQEE-------TRGQQQALLRDHKALAQLQRRQEAE-----LEG 1094
              +L  L+ E  AA Q ++E        R + + LL   KA A+ + R  +E     LE 
Sbjct: 1701 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS-KARAEEESRSTSEKSKQRLEA 1759

Query: 1095 LLVRHRDL---KANMRAL-ELAHRELQGRHEQLQAQRASVE---AQEVALLAERERLMQD 1147
               R R+L    A +RAL E A R+ Q   E    QRA  E   A+++A + E  RL  +
Sbjct: 1760 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1819

Query: 1148 GHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGE----RGELRGRLARL------E 1197
                   E  L+  ++E++R + L  + + +R  L+ +    + ++  RLA+L      E
Sbjct: 1820 A------EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1873

Query: 1198 LE------------RAQLEMQSQQLRES-------NQQLDLSACRLTTQCELLTQLRSAQ 1238
            LE            R Q+E +   L+ S         +L+L   R+ +  E    LRS +
Sbjct: 1874 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE--DTLRSKE 1931

Query: 1239 EEE-----NRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQK 1290
            + E      RQL AE +   RE  E +++SL + +   R+++  L+++  L+ + ++
Sbjct: 1932 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 1988



 Score =  154 bits (389), Expect = 6e-37
 Identities = 291/1222 (23%), Positives = 499/1222 (40%), Gaps = 233/1222 (19%)

Query: 269  RLRQELEEKAELLLDS---QAEVQGLEAEIRRLRQEAQALSGQAKRAELYREE------- 318
            R+ Q LE    +L  +   Q E++ L  ++R  R+ A  L    + A   +E+       
Sbjct: 1148 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1207

Query: 319  -AEALRERAGRLPRLQEELRRCRERLQAAE------------------AYKSQLE----- 354
             ++A+RE+  +   L EE+ R  E+++  +                   YK+QLE     
Sbjct: 1208 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1267

Query: 355  --EERVLSGVLEASK-------------ALLEEQLEAARERCARLHETQR----ENLLLR 395
              + +V SG     +              L  + ++   E   R+ E +R    +    R
Sbjct: 1268 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1327

Query: 396  TRLGEAHAELDSLRHQVDQLAEENVELE---LELQRSLEPPPGSPGEAPLAGAAP--SLQ 450
             RL E  A L+  R   +  A+   + E    ELQ+ ++       EA +       S+Q
Sbjct: 1328 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1387

Query: 451  DEVRE------------------AEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAP 492
            +E+++                  AE  RLR +E E R +R  L+  + Q GG    L+A 
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQAL 1446

Query: 493  REDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECP---- 548
            R        EEA           + L ++ +D   Q    A   L S ++A AE      
Sbjct: 1447 RAR-----AEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQ 1500

Query: 549  -----------QAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQES--PEKAGRR 595
                       QA +++ +  ++ ++ A     A + + + + + ++++ +   EK  + 
Sbjct: 1501 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1560

Query: 596  SSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEP 655
                    VA  Q      +  Q        RE  + EL  E W L+          +E 
Sbjct: 1561 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL--ERWQLK---------ANEA 1609

Query: 656  SSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGA-----LEVQV 710
              ++L+ +E   Q   LA  +AE ++ +   E   R  A ++  ++ E A      + Q+
Sbjct: 1610 LRLRLQAEEVAQQ-KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1668

Query: 711  WEGPIPGESLA------------SGVAEQEALREEVAQLRRKAEAL---GDELEAQARKL 755
             EG       A             G  +++ L EE+A+L+R+A A      ELEA+  K+
Sbjct: 1669 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1728

Query: 756  EAQ---------NTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQ---- 802
             A+           E    S      +R EAEA R  E  A E ARLR   E A +    
Sbjct: 1729 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQL 1787

Query: 803  -ELESASQEREA---LVEALAAAGRERR----------QWEREGSRLRAQSEAAEERMQV 848
             E ++A Q  EA   L E LAA G   R          + E E  RLR  +E    + + 
Sbjct: 1788 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1847

Query: 849  LESEGRQH-------------------------LEEAERERREKE----ALQAELEKAVV 879
            LE +  QH                         +E+  R+RR+ E    AL+A  EKA  
Sbjct: 1848 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1907

Query: 880  RGKELGARL-------EHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQA--- 929
               EL   L       E   R  EQA LE     +    + +R +  E+R++  L A   
Sbjct: 1908 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1967

Query: 930  AATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAM 989
            AA  ++ AL E++    ++EE   +LR+       ++    Q  E    RL   E+++A 
Sbjct: 1968 AARQRKAALEEVERLKAKVEEAR-RLRERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF 2024

Query: 990  LVAEK-AALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHR 1048
             V +K   LQ  LQ  +  L  L+G A+     ++ A+E  +R+QAE+   + + Q    
Sbjct: 2025 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQSRRQ---- 2078

Query: 1049 KLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRA 1108
                  EE    +QS EE     QA  R     A  + R+EAE E    R +  +A +R 
Sbjct: 2079 -----VEEAERLKQSAEE-----QAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAALRQ 2127

Query: 1109 LELAHRELQGRHEQLQAQRASVEAQ-EVALLAERERLMQDGHRQRGLEEELRRLQSEHDR 1167
             + A  E++ +H++   Q    +AQ E  L   R +L +  H++  L+EEL+RL++E   
Sbjct: 2128 KQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2186

Query: 1168 AQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQS--------QQLRESNQQLDL 1219
            A    +++  E   ++ +  EL    AR+E E   L ++         Q+  E  +Q+  
Sbjct: 2187 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2246

Query: 1220 SACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERS--LESRDHLHREQREY 1277
             A RL+   +   +LR   EE+  Q  A  + + +E  + ++ +  L++   L ++Q+E 
Sbjct: 2247 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2306

Query: 1278 L-DQLNALRREKQKLVEKIMDQ 1298
              +Q   L+ +K+++ +++ ++
Sbjct: 2307 AQEQARRLQEDKEQMAQQLAEE 2328



 Score =  140 bits (353), Expect = 9e-33
 Identities = 259/1088 (23%), Positives = 436/1088 (40%), Gaps = 161/1088 (14%)

Query: 217  ARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEE 276
            A E+ +  + LAE  LE++       A  R  AE     L  +    + Q + L +EL  
Sbjct: 1647 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1706

Query: 277  KAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAE----------LYREEAEA----- 321
                   +  + Q LEAE+ ++R E + L     RAE            R EAEA     
Sbjct: 1707 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1766

Query: 322  LRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVL----EASKALLEEQL--- 374
            L E A RL  L EE +R R+ L   +A + + E ERVL+  L    EA++   E ++   
Sbjct: 1767 LAEEAARLRALAEEAKRQRQ-LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1825

Query: 375  --EAARERCARLHET---QRENLL---------LRTRLGEAHAELDSLRHQVDQLAEENV 420
              EA  ER  RL E    QR  L          +  RL +     DS   +   L E+ +
Sbjct: 1826 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1885

Query: 421  -------ELELELQRSLEPPPGSPGEAPL------AGAAPSLQD-EVREAEAGRLRTL-E 465
                   E  L L+ S E       E  L      + A  +L+  E  E EA R R L  
Sbjct: 1886 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1945

Query: 466  RENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDG 525
             E R  R   + +Q     +    EA R+      LEE  +     + + + L ++A   
Sbjct: 1946 EEERRRREAEERVQKSLAAEE---EAARQRKA--ALEEVERLKAKVEEA-RRLRERAEQE 1999

Query: 526  GPQALDLAPPALDSVLEASAECPQ-APDSDPQEAESPLQAAAMDPQASDWSPQESGSPVE 584
              + L LA  A    L+A  +    A     QE +  LQ    +    D    E+ +   
Sbjct: 2000 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ---QEQSVLDQLRGEAEAARR 2056

Query: 585  TQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQE 644
              E  E+A  ++  ++  S         +++  + L    E +   + +    A  LR+E
Sbjct: 2057 AAEEAEEARVQAEREAAQS-------RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2109

Query: 645  GPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE- 703
              +     ++     L +++            AE  +H +  E T+R    QK Q + E 
Sbjct: 2110 AEQEAARRAQAEQAALRQKQ---------AADAEMEKHKKFAEQTLR----QKAQVEQEL 2156

Query: 704  GALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAE-------ALGDELEAQARKLE 756
              L +Q+ E       L   +   +A   E A+ R + E          +EL     ++E
Sbjct: 2157 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2216

Query: 757  AQN--------TEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESAS 808
            A+N            R  +E A+  +  AE        A E ARLR+  E      E  +
Sbjct: 2217 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLA 2270

Query: 809  QEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEE----AERER 864
            Q+R AL E +    +E+ Q  +E +RL+A++E  +++ ++ + + R+  E+    A++  
Sbjct: 2271 QQR-ALAEKML---KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2326

Query: 865  REKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLE 924
             E +  Q  LE    R  E+ A  E L  +L  A + R +   E+++Q  R Q  E   +
Sbjct: 2327 EETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2384

Query: 925  AELQAAATSKEEALME-LKTRALQLEEELFQLRQGPAGLGPKK------------RAEPQ 971
                  AT ++  L++ L+ +  Q + +  +LR+  A L  +K            ++E  
Sbjct: 2385 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2444

Query: 972  LVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSR 1031
                Q   L E +      ++EK +L  + + +E +   L+   Q+ + ++Q+ +E   R
Sbjct: 2445 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2504

Query: 1032 LQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAE 1091
             Q +        QE  R +  +EE  R   +++E  R +Q+ L +      + QRRQ+ E
Sbjct: 2505 QQQQME------QERQRLVASMEEARRRQHEAEEGVRRKQEELQQ-----LEQQRRQQEE 2553

Query: 1092 LEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRA----------------SVEAQ-E 1134
            L  L   ++ L+  ++ LE  HR      E++ A +                 + EA+ E
Sbjct: 2554 L--LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2611

Query: 1135 VALLAERERLMQDGHRQRGL--EEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGR 1192
             +    R ++     ++ G+   EEL+RL   H      LA     R  LQG R  + G 
Sbjct: 2612 HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE-LARREDVRHYLQG-RSSIAGL 2669

Query: 1193 LARLELER 1200
            L +   E+
Sbjct: 2670 LLKATNEK 2677



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 148/629 (23%), Positives = 255/629 (40%), Gaps = 60/629 (9%)

Query: 716  PGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRA 775
            P    A  +AEQ+  + EV  L +    L  E E +   L   +  A  L  EL +    
Sbjct: 983  PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE-KVLALPEPSPAAPTLRSEL-ELTLG 1040

Query: 776  EAEAHREAEAQAWEQARLREAV---EAAGQELESASQEREALVEALAAAGRERRQWEREG 832
            + E  R   A   E+ +    V       +E+  A +E+    +A+ A   E    +   
Sbjct: 1041 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1100

Query: 833  SRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQ 892
             +LRAQ+EA +     L  E R   E  ER ++       E+E+   R  +L   LE  Q
Sbjct: 1101 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQ 1157

Query: 893  RELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEEL 952
              L Q  + RQ  L +   Q + Y+     L A LQ  A  ++E +  +     Q   E 
Sbjct: 1158 AVLAQTDV-RQRELEQLGRQLRYYRESADPLGAWLQ-DARRRQEQIQAMPLADSQAVRE- 1214

Query: 953  FQLRQGPAGLGPKKRAEPQLVETQNVR---LIEVERSNAMLVAEKAALQGQLQHLEGQLG 1009
             QLRQ  A L   +R   ++ E Q      +  ++     LV  KA L+        +  
Sbjct: 1215 -QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS--PAKKP 1271

Query: 1010 SLQGRAQELLLQSQRAQEHSSRLQAEKS-VLEIQGQELHRKLEVLEEEVRAARQSQEETR 1068
             +Q  ++ ++ +    + H S L    S  ++   + L R    +EEE R A Q + E R
Sbjct: 1272 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR----MEEEERLAEQQRAEER 1327

Query: 1069 ---GQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQA 1125
                + +A L   + LA+   + +A+ E      ++L+  M+  E+  RE      Q Q 
Sbjct: 1328 ERLAEVEAALEKQRQLAEAHAQAKAQAER---EAKELQQRMQE-EVVRREEAAVDAQQQK 1383

Query: 1126 QRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGE 1185
            +    E Q++   +E E +     +    E    R++ E    ++ L    R+RG  +GE
Sbjct: 1384 RSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1442

Query: 1186 RGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQL 1245
               LR R    E ++ Q + ++++LR                       R  Q+E  R+ 
Sbjct: 1443 LQALRARAEEAEAQKRQAQEEAERLR-----------------------RQVQDESQRKR 1479

Query: 1246 LAEVQALSRENREL-----LERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYR 1300
             AEV+  SR   E       +R+L++ + L  +  E   +L     E+ + V+  ++  +
Sbjct: 1480 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1539

Query: 1301 VLEPVPLPRTKKGSWLADKVKRLMRPRRE 1329
                  L ++K+ S+ A+K  +L R  +E
Sbjct: 1540 RSAEAEL-QSKRASF-AEKTAQLERSLQE 1566



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 131/567 (23%), Positives = 217/567 (38%), Gaps = 69/567 (12%)

Query: 694  AW-QKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAE-ALGDELEAQ 751
            AW ++ Q + +GA     W   +P  S+ + +     L + + + R K E A  DE +  
Sbjct: 498  AWVEENQHRVDGA----EWGVDLP--SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS 551

Query: 752  ARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQER 811
                 A      RL  + A+   +     R  E+       L   V AA +EL   +++ 
Sbjct: 552  PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES-------LHSFVAAATKELMWLNEKE 604

Query: 812  EALVEALAAAGRERRQWEREG-SRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEAL 870
            E  V    +        ++E  S L  + E  E++++ L++ G + L E    R   E+ 
Sbjct: 605  EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 664

Query: 871  QAELEKAVVRGKELGARLEHLQRELEQAALERQEF--LREKESQHQRYQ-GLEQRLEAEL 927
            QA L+       +L   +E     L++ A   Q F  +RE E Q Q+ Q  L ++   + 
Sbjct: 665  QAALQTQWSWMLQLCCCIE---AHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 721

Query: 928  QAAATSKEEALMELKTRALQLEEE------LFQLRQGPAGLGPKKRAEPQ-----LVETQ 976
             A  T  E+ L + +    QL E       L +  +    L P+  A P      L+   
Sbjct: 722  SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC 781

Query: 977  NVRLIEV---ERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQ 1033
            + + +EV   +     LV        ++    G   ++      +   +Q AQE  +RL+
Sbjct: 782  DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE 841

Query: 1034 AEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELE 1093
            A+   L     +LH  ++ L                  Q+L RD     QL R       
Sbjct: 842  AQHQALVTLWHQLHVDMKSLL---------------AWQSLRRD----VQLIRSWS---- 878

Query: 1094 GLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRG 1153
              L   R LK   +   L   EL  +     +Q A     E  L+AERE      H Q+ 
Sbjct: 879  --LATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQ- 935

Query: 1154 LEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELER------AQLEMQS 1207
            L + L +   E  R Q  ++EL   R +L+        RL RL L++      AQ   + 
Sbjct: 936  LLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL-RLPLDKEPARECAQRIAEQ 994

Query: 1208 QQLRESNQQLDLSACRLTTQCELLTQL 1234
            Q+ +   + L     RL+ + E +  L
Sbjct: 995  QKAQAEVEGLGKGVARLSAEAEKVLAL 1021


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  199 bits (505), Expect = 2e-50
 Identities = 333/1276 (26%), Positives = 533/1276 (41%), Gaps = 170/1276 (13%)

Query: 106  QEELQLLILSPPPDLQTLGFDPLSEEA----VEQLEGVLRLLLGASVQCEHRELFIRHIQ 161
            QEELQ L  S   ++Q       + E     +E+   V+RL L A+     R+      +
Sbjct: 1556 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT----ERQRGGAEGE 1611

Query: 162  GLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARERD 221
              +L  ++E A A +   Q  A  +      +      AE+E+ SR  +   ++ ARE+ 
Sbjct: 1612 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR--VKAEAEAAREKQ 1669

Query: 222  LGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELL 281
               Q L EL L+ E    R        A      L     +A+A+L+  R    EK   L
Sbjct: 1670 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1729

Query: 282  LDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRER-------AGRLPRLQE 334
               +  +Q     + +LR+EA+  + Q   AE  REEAE   ER       A RL    E
Sbjct: 1730 ---ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1786

Query: 335  ELRRCRERLQA-AEAYKSQLEEERVLSGVLEAS----KALLEEQLE--------AARERC 381
            E+ + +   QA AE  K + E E    G  E      + L E++LE         A++R 
Sbjct: 1787 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1846

Query: 382  ARLHETQRENLLLRTRLGEAHA-----ELDSLRHQVDQLAEENVELELELQR---SLEPP 433
            A   E  R  L   T  GE        EL  L+ +     ++  ELE EL +    +E  
Sbjct: 1847 AAEQELIR--LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1904

Query: 434  PGSPGEAPLAGAAPSLQDEVR-EAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAP 492
              S   A     + S + + R EAEAGR R L  E   LR L +             EA 
Sbjct: 1905 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE-------------EAK 1951

Query: 493  REDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPD 552
            R+  +    E+A +       + + L +K    G +A  L   A  ++ E  AE  +   
Sbjct: 1952 RQRQLAE--EDAARQRA---EAERVLAEKLAAIG-EATRLKTEAEIALKEKEAENERLRR 2005

Query: 553  SDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGT 612
                EA    Q   ++ QA+     +  + +E + +  +    S L+    +        
Sbjct: 2006 LAEDEA---FQRRRLEEQAA-----QHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 2057

Query: 613  KIQAPQLLGGETEGREAPQG--ELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGL 670
            +    ++L  +    +A  G  EL  E   +R    +         S +  E E   Q  
Sbjct: 2058 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL------RSKEQAELEAARQRQ 2111

Query: 671  DLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE----GALEVQVWEGPIPGESLASGVAE 726
              A  +   RE ++R++ ++        Q+K+       L+ +V E     E      A 
Sbjct: 2112 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2171

Query: 727  QEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAA------RLSKELAQARRAEAEAH 780
            Q  L +E AQ R +AE        Q ++ E Q T         +L  E   ARRA  EA 
Sbjct: 2172 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA- 2230

Query: 781  REAEAQA-WEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQS 839
             EA  QA  E A+ R  VE A +  +SA ++ +A  +A AAA + R++ E+E +R     
Sbjct: 2231 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2290

Query: 840  EAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAA 899
            +AA  + Q  ++E  +H + AE+  R+K  ++ EL    ++ +E   +   L  EL++  
Sbjct: 2291 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2350

Query: 900  LERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGP 959
             E  E  R      QR Q  E+     +Q    SK +A +E + RAL L +         
Sbjct: 2351 AEATEAAR------QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD--------- 2395

Query: 960  AGLGPKKRAEPQL-VETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQEL 1018
                 K   +  L  E + ++ +  E +   + A++AA   QL   E  L   +  A+++
Sbjct: 2396 -----KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL--AEEDLAQQRALAEKM 2448

Query: 1019 LLQSQRAQEHSSRLQAEKSVLEIQ---GQELHRKLEVLEEEVRAARQSQEETRGQQQALL 1075
            L +  +A + ++RL+AE  +L+ Q    QE  R+L+  E++ + A+Q  EET+G Q+ L 
Sbjct: 2449 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ--EDKEQMAQQLAEETQGFQRTL- 2505

Query: 1076 RDHKALAQLQRRQEAELEGLLVRHRDL-KANMRALELAHRELQGRHEQLQAQRASVEAQE 1134
               +A  Q Q    AE E L +R  ++ +A  RA E              AQR   +A+E
Sbjct: 2506 ---EAERQRQLEMSAEAERLKLRVAEMSRAQARAEE-------------DAQRFRKQAEE 2549

Query: 1135 VALLAERERLMQDGHRQRGLEEELRRLQSEHD--RAQMLLAELSRERGELQGERGELRGR 1192
            +     R  L            E++R QS+HD  R +  +AEL RE+ +LQ E      +
Sbjct: 2550 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE-----AK 2604

Query: 1193 LARLELERAQLEMQSQQLRESN--QQLDLSACRLTTQCELL------------------- 1231
            L +L+ E  Q   Q Q L+E+   QQ  LS      Q E                     
Sbjct: 2605 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2664

Query: 1232 TQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKL 1291
             QLR  Q+ + +Q+  E Q L     E   R  E+ + + R+Q E L QL   RR++++L
Sbjct: 2665 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE-LQQLEQQRRQQEEL 2723

Query: 1292 V----EKIMDQYRVLE 1303
            +    +++ +Q ++LE
Sbjct: 2724 LAEENQRLREQLQLLE 2739



 Score =  159 bits (401), Expect = 2e-38
 Identities = 300/1197 (25%), Positives = 491/1197 (41%), Gaps = 217/1197 (18%)

Query: 193  DPGELAPAELEMLSR---SLMGTLSKLARERDLGAQ---RLAELLLEREPLCLRPEAPSR 246
            D G   P +  M  R   S      +L +  + GAQ   R    + E + + L+ EA   
Sbjct: 1079 DAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACET 1138

Query: 247  APAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALS 306
                   H L L L    A  R   Q + E+ +    +QAEV+GL   + RL  EA    
Sbjct: 1139 RTV----HRLRLPLDKEPA--RECAQRIAEQQK----AQAEVEGLGKGVARLSAEA---- 1184

Query: 307  GQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKS-QLEEERVLSGVLEA 365
                      E+  AL E +   P L+ EL     +L+   +  +  LE+ + +S V+  
Sbjct: 1185 ----------EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1234

Query: 366  SKA------LLEEQLEAARERCARLHETQRENLLLRTRLGEAHAE---LDSLRHQV---- 412
            ++         EEQL+ A+   A L E +     L+    +A A+    D+LR ++    
Sbjct: 1235 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQ 1294

Query: 413  ---DQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENR 469
               ++L + + E ++E++R  E       +      A   Q +VR+      R LE+  R
Sbjct: 1295 EVGERLQQRHGERDVEVERWRE----RVAQLLERWQAVLAQTDVRQ------RELEQLGR 1344

Query: 470  ELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQA 529
            +LR   +                  DP+   L++A +        P    Q  R+   Q 
Sbjct: 1345 QLRYYRE----------------SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE 1388

Query: 530  LDLAPPALDSVLEASAECPQAPDS-----DPQEAESPLQAAAMDPQASDWSPQ--ESGSP 582
              L    ++   E   EC +            E +     A ++P AS       +SGS 
Sbjct: 1389 QALL-EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1447

Query: 583  VETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLR 642
               QE  +     S L +  S         K  +  L   E E R A Q           
Sbjct: 1448 SVIQEYVDLRTHYSELTTLTS------QYIKFISETLRRMEEEERLAEQ----------- 1490

Query: 643  QEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKS 702
            Q   E +      ++++ + Q         A  + EA+E  QR++        ++  ++ 
Sbjct: 1491 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--------EEVVRRE 1542

Query: 703  EGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEA 762
            E A++ Q                ++ +++EE+ QLR+ +EA   E++A+AR+ EA     
Sbjct: 1543 EAAVDAQ---------------QQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSR 1584

Query: 763  ARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAG 822
             R+ +E+   R       R+      E   LR   E A  +   A +E E L   +    
Sbjct: 1585 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1644

Query: 823  RERRQWERE-GSRLRAQSEAAEERMQVLES--EGRQHLEEAERERREKEALQAELEKAVV 879
            + +RQ E E  SR++A++EAA E+ + L++  E R   EEAER  R     QAE+E+A  
Sbjct: 1645 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVERA-- 1697

Query: 880  RGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQ------RLEAELQA---- 929
              +++   LE  QR  E     ++    EK +Q +R    E       R EAE +A    
Sbjct: 1698 --RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1755

Query: 930  -AATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNA 988
             A  ++EEA  EL+   L+  E L +LR     +  +K       E Q     E E    
Sbjct: 1756 EAERAREEAERELERWQLKANEAL-RLRLQAEEVAQQKSLAQAEAEKQKEE-AEREARRR 1813

Query: 989  MLVAEKAALQGQL--QHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQEL 1046
                E+A  Q +L  Q LE Q    +G AQ+ L     A++   RL+AE    E Q Q L
Sbjct: 1814 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL----AAEQELIRLRAETEQGEQQRQLL 1869

Query: 1047 HRKLEVLEEEVRAARQSQEE-------TRGQQQALLRDHKALAQLQRRQEAE-----LEG 1094
              +L  L+ E  AA Q ++E        R + + LL   KA A+ + R  +E     LE 
Sbjct: 1870 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS-KARAEEESRSTSEKSKQRLEA 1928

Query: 1095 LLVRHRDL---KANMRAL-ELAHRELQGRHEQLQAQRASVE---AQEVALLAERERLMQD 1147
               R R+L    A +RAL E A R+ Q   E    QRA  E   A+++A + E  RL  +
Sbjct: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1988

Query: 1148 GHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGE----RGELRGRLARL------E 1197
                   E  L+  ++E++R + L  + + +R  L+ +    + ++  RLA+L      E
Sbjct: 1989 A------EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 2042

Query: 1198 LE------------RAQLEMQSQQLRES-------NQQLDLSACRLTTQCELLTQLRSAQ 1238
            LE            R Q+E +   L+ S         +L+L   R+ +  E    LRS +
Sbjct: 2043 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE--DTLRSKE 2100

Query: 1239 EEE-----NRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQK 1290
            + E      RQL AE +   RE  E +++SL + +   R+++  L+++  L+ + ++
Sbjct: 2101 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2157



 Score =  154 bits (389), Expect = 6e-37
 Identities = 291/1222 (23%), Positives = 499/1222 (40%), Gaps = 233/1222 (19%)

Query: 269  RLRQELEEKAELLLDS---QAEVQGLEAEIRRLRQEAQALSGQAKRAELYREE------- 318
            R+ Q LE    +L  +   Q E++ L  ++R  R+ A  L    + A   +E+       
Sbjct: 1317 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1376

Query: 319  -AEALRERAGRLPRLQEELRRCRERLQAAE------------------AYKSQLE----- 354
             ++A+RE+  +   L EE+ R  E+++  +                   YK+QLE     
Sbjct: 1377 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1436

Query: 355  --EERVLSGVLEASK-------------ALLEEQLEAARERCARLHETQR----ENLLLR 395
              + +V SG     +              L  + ++   E   R+ E +R    +    R
Sbjct: 1437 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1496

Query: 396  TRLGEAHAELDSLRHQVDQLAEENVELE---LELQRSLEPPPGSPGEAPLAGAAP--SLQ 450
             RL E  A L+  R   +  A+   + E    ELQ+ ++       EA +       S+Q
Sbjct: 1497 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1556

Query: 451  DEVRE------------------AEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAP 492
            +E+++                  AE  RLR +E E R +R  L+  + Q GG    L+A 
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQAL 1615

Query: 493  REDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECP---- 548
            R        EEA           + L ++ +D   Q    A   L S ++A AE      
Sbjct: 1616 RAR-----AEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQ 1669

Query: 549  -----------QAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQES--PEKAGRR 595
                       QA +++ +  ++ ++ A     A + + + + + ++++ +   EK  + 
Sbjct: 1670 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1729

Query: 596  SSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEP 655
                    VA  Q      +  Q        RE  + EL  E W L+          +E 
Sbjct: 1730 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL--ERWQLK---------ANEA 1778

Query: 656  SSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGA-----LEVQV 710
              ++L+ +E   Q   LA  +AE ++ +   E   R  A ++  ++ E A      + Q+
Sbjct: 1779 LRLRLQAEEVAQQ-KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1837

Query: 711  WEGPIPGESLA------------SGVAEQEALREEVAQLRRKAEAL---GDELEAQARKL 755
             EG       A             G  +++ L EE+A+L+R+A A      ELEA+  K+
Sbjct: 1838 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1897

Query: 756  EAQ---------NTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQ---- 802
             A+           E    S      +R EAEA R  E  A E ARLR   E A +    
Sbjct: 1898 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQL 1956

Query: 803  -ELESASQEREA---LVEALAAAGRERR----------QWEREGSRLRAQSEAAEERMQV 848
             E ++A Q  EA   L E LAA G   R          + E E  RLR  +E    + + 
Sbjct: 1957 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 2016

Query: 849  LESEGRQH-------------------------LEEAERERREKE----ALQAELEKAVV 879
            LE +  QH                         +E+  R+RR+ E    AL+A  EKA  
Sbjct: 2017 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 2076

Query: 880  RGKELGARL-------EHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQA--- 929
               EL   L       E   R  EQA LE     +    + +R +  E+R++  L A   
Sbjct: 2077 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136

Query: 930  AATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAM 989
            AA  ++ AL E++    ++EE   +LR+       ++    Q  E    RL   E+++A 
Sbjct: 2137 AARQRKAALEEVERLKAKVEEAR-RLRERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF 2193

Query: 990  LVAEK-AALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHR 1048
             V +K   LQ  LQ  +  L  L+G A+     ++ A+E  +R+QAE+   + + Q    
Sbjct: 2194 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQSRRQ---- 2247

Query: 1049 KLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRA 1108
                  EE    +QS EE     QA  R     A  + R+EAE E    R +  +A +R 
Sbjct: 2248 -----VEEAERLKQSAEE-----QAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAALRQ 2296

Query: 1109 LELAHRELQGRHEQLQAQRASVEAQ-EVALLAERERLMQDGHRQRGLEEELRRLQSEHDR 1167
             + A  E++ +H++   Q    +AQ E  L   R +L +  H++  L+EEL+RL++E   
Sbjct: 2297 KQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2355

Query: 1168 AQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQS--------QQLRESNQQLDL 1219
            A    +++  E   ++ +  EL    AR+E E   L ++         Q+  E  +Q+  
Sbjct: 2356 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2415

Query: 1220 SACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERS--LESRDHLHREQREY 1277
             A RL+   +   +LR   EE+  Q  A  + + +E  + ++ +  L++   L ++Q+E 
Sbjct: 2416 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2475

Query: 1278 L-DQLNALRREKQKLVEKIMDQ 1298
              +Q   L+ +K+++ +++ ++
Sbjct: 2476 AQEQARRLQEDKEQMAQQLAEE 2497



 Score =  140 bits (353), Expect = 9e-33
 Identities = 259/1088 (23%), Positives = 436/1088 (40%), Gaps = 161/1088 (14%)

Query: 217  ARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEE 276
            A E+ +  + LAE  LE++       A  R  AE     L  +    + Q + L +EL  
Sbjct: 1816 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1875

Query: 277  KAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAE----------LYREEAEA----- 321
                   +  + Q LEAE+ ++R E + L     RAE            R EAEA     
Sbjct: 1876 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1935

Query: 322  LRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVL----EASKALLEEQL--- 374
            L E A RL  L EE +R R+ L   +A + + E ERVL+  L    EA++   E ++   
Sbjct: 1936 LAEEAARLRALAEEAKRQRQ-LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1994

Query: 375  --EAARERCARLHET---QRENLL---------LRTRLGEAHAELDSLRHQVDQLAEENV 420
              EA  ER  RL E    QR  L          +  RL +     DS   +   L E+ +
Sbjct: 1995 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 2054

Query: 421  -------ELELELQRSLEPPPGSPGEAPL------AGAAPSLQD-EVREAEAGRLRTL-E 465
                   E  L L+ S E       E  L      + A  +L+  E  E EA R R L  
Sbjct: 2055 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 2114

Query: 466  RENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDG 525
             E R  R   + +Q     +    EA R+      LEE  +     + + + L ++A   
Sbjct: 2115 EEERRRREAEERVQKSLAAEE---EAARQRKA--ALEEVERLKAKVEEA-RRLRERAEQE 2168

Query: 526  GPQALDLAPPALDSVLEASAECPQ-APDSDPQEAESPLQAAAMDPQASDWSPQESGSPVE 584
              + L LA  A    L+A  +    A     QE +  LQ    +    D    E+ +   
Sbjct: 2169 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ---QEQSVLDQLRGEAEAARR 2225

Query: 585  TQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQE 644
              E  E+A  ++  ++  S         +++  + L    E +   + +    A  LR+E
Sbjct: 2226 AAEEAEEARVQAEREAAQS-------RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2278

Query: 645  GPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE- 703
              +     ++     L +++            AE  +H +  E T+R    QK Q + E 
Sbjct: 2279 AEQEAARRAQAEQAALRQKQ---------AADAEMEKHKKFAEQTLR----QKAQVEQEL 2325

Query: 704  GALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAE-------ALGDELEAQARKLE 756
              L +Q+ E       L   +   +A   E A+ R + E          +EL     ++E
Sbjct: 2326 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2385

Query: 757  AQN--------TEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESAS 808
            A+N            R  +E A+  +  AE        A E ARLR+  E      E  +
Sbjct: 2386 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLA 2439

Query: 809  QEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEE----AERER 864
            Q+R AL E +    +E+ Q  +E +RL+A++E  +++ ++ + + R+  E+    A++  
Sbjct: 2440 QQR-ALAEKML---KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2495

Query: 865  REKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLE 924
             E +  Q  LE    R  E+ A  E L  +L  A + R +   E+++Q  R Q  E   +
Sbjct: 2496 EETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2553

Query: 925  AELQAAATSKEEALME-LKTRALQLEEELFQLRQGPAGLGPKK------------RAEPQ 971
                  AT ++  L++ L+ +  Q + +  +LR+  A L  +K            ++E  
Sbjct: 2554 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2613

Query: 972  LVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSR 1031
                Q   L E +      ++EK +L  + + +E +   L+   Q+ + ++Q+ +E   R
Sbjct: 2614 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2673

Query: 1032 LQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAE 1091
             Q +        QE  R +  +EE  R   +++E  R +Q+ L +      + QRRQ+ E
Sbjct: 2674 QQQQME------QERQRLVASMEEARRRQHEAEEGVRRKQEELQQ-----LEQQRRQQEE 2722

Query: 1092 LEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRA----------------SVEAQ-E 1134
            L  L   ++ L+  ++ LE  HR      E++ A +                 + EA+ E
Sbjct: 2723 L--LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2780

Query: 1135 VALLAERERLMQDGHRQRGL--EEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGR 1192
             +    R ++     ++ G+   EEL+RL   H      LA     R  LQG R  + G 
Sbjct: 2781 HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE-LARREDVRHYLQG-RSSIAGL 2838

Query: 1193 LARLELER 1200
            L +   E+
Sbjct: 2839 LLKATNEK 2846



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 148/629 (23%), Positives = 255/629 (40%), Gaps = 60/629 (9%)

Query: 716  PGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRA 775
            P    A  +AEQ+  + EV  L +    L  E E +   L   +  A  L  EL +    
Sbjct: 1152 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE-KVLALPEPSPAAPTLRSEL-ELTLG 1209

Query: 776  EAEAHREAEAQAWEQARLREAV---EAAGQELESASQEREALVEALAAAGRERRQWEREG 832
            + E  R   A   E+ +    V       +E+  A +E+    +A+ A   E    +   
Sbjct: 1210 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1269

Query: 833  SRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQ 892
             +LRAQ+EA +     L  E R   E  ER ++       E+E+   R  +L   LE  Q
Sbjct: 1270 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQ 1326

Query: 893  RELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEEL 952
              L Q  + RQ  L +   Q + Y+     L A LQ  A  ++E +  +     Q   E 
Sbjct: 1327 AVLAQTDV-RQRELEQLGRQLRYYRESADPLGAWLQ-DARRRQEQIQAMPLADSQAVRE- 1383

Query: 953  FQLRQGPAGLGPKKRAEPQLVETQNVR---LIEVERSNAMLVAEKAALQGQLQHLEGQLG 1009
             QLRQ  A L   +R   ++ E Q      +  ++     LV  KA L+        +  
Sbjct: 1384 -QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS--PAKKP 1440

Query: 1010 SLQGRAQELLLQSQRAQEHSSRLQAEKS-VLEIQGQELHRKLEVLEEEVRAARQSQEETR 1068
             +Q  ++ ++ +    + H S L    S  ++   + L R    +EEE R A Q + E R
Sbjct: 1441 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR----MEEEERLAEQQRAEER 1496

Query: 1069 ---GQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQA 1125
                + +A L   + LA+   + +A+ E      ++L+  M+  E+  RE      Q Q 
Sbjct: 1497 ERLAEVEAALEKQRQLAEAHAQAKAQAER---EAKELQQRMQE-EVVRREEAAVDAQQQK 1552

Query: 1126 QRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGE 1185
            +    E Q++   +E E +     +    E    R++ E    ++ L    R+RG  +GE
Sbjct: 1553 RSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1611

Query: 1186 RGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQL 1245
               LR R    E ++ Q + ++++LR                       R  Q+E  R+ 
Sbjct: 1612 LQALRARAEEAEAQKRQAQEEAERLR-----------------------RQVQDESQRKR 1648

Query: 1246 LAEVQALSRENREL-----LERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYR 1300
             AEV+  SR   E       +R+L++ + L  +  E   +L     E+ + V+  ++  +
Sbjct: 1649 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1708

Query: 1301 VLEPVPLPRTKKGSWLADKVKRLMRPRRE 1329
                  L ++K+ S+ A+K  +L R  +E
Sbjct: 1709 RSAEAEL-QSKRASF-AEKTAQLERSLQE 1735



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 131/567 (23%), Positives = 217/567 (38%), Gaps = 69/567 (12%)

Query: 694  AW-QKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAE-ALGDELEAQ 751
            AW ++ Q + +GA     W   +P  S+ + +     L + + + R K E A  DE +  
Sbjct: 667  AWVEENQHRVDGA----EWGVDLP--SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS 720

Query: 752  ARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQER 811
                 A      RL  + A+   +     R  E+       L   V AA +EL   +++ 
Sbjct: 721  PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES-------LHSFVAAATKELMWLNEKE 773

Query: 812  EALVEALAAAGRERRQWEREG-SRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEAL 870
            E  V    +        ++E  S L  + E  E++++ L++ G + L E    R   E+ 
Sbjct: 774  EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 833

Query: 871  QAELEKAVVRGKELGARLEHLQRELEQAALERQEF--LREKESQHQRYQ-GLEQRLEAEL 927
            QA L+       +L   +E     L++ A   Q F  +RE E Q Q+ Q  L ++   + 
Sbjct: 834  QAALQTQWSWMLQLCCCIE---AHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 890

Query: 928  QAAATSKEEALMELKTRALQLEEE------LFQLRQGPAGLGPKKRAEPQ-----LVETQ 976
             A  T  E+ L + +    QL E       L +  +    L P+  A P      L+   
Sbjct: 891  SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC 950

Query: 977  NVRLIEV---ERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQ 1033
            + + +EV   +     LV        ++    G   ++      +   +Q AQE  +RL+
Sbjct: 951  DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE 1010

Query: 1034 AEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELE 1093
            A+   L     +LH  ++ L                  Q+L RD     QL R       
Sbjct: 1011 AQHQALVTLWHQLHVDMKSLL---------------AWQSLRRD----VQLIRSWS---- 1047

Query: 1094 GLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRG 1153
              L   R LK   +   L   EL  +     +Q A     E  L+AERE      H Q+ 
Sbjct: 1048 --LATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQ- 1104

Query: 1154 LEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELER------AQLEMQS 1207
            L + L +   E  R Q  ++EL   R +L+        RL RL L++      AQ   + 
Sbjct: 1105 LLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL-RLPLDKEPARECAQRIAEQ 1163

Query: 1208 QQLRESNQQLDLSACRLTTQCELLTQL 1234
            Q+ +   + L     RL+ + E +  L
Sbjct: 1164 QKAQAEVEGLGKGVARLSAEAEKVLAL 1190


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  199 bits (505), Expect = 2e-50
 Identities = 333/1276 (26%), Positives = 533/1276 (41%), Gaps = 170/1276 (13%)

Query: 106  QEELQLLILSPPPDLQTLGFDPLSEEA----VEQLEGVLRLLLGASVQCEHRELFIRHIQ 161
            QEELQ L  S   ++Q       + E     +E+   V+RL L A+     R+      +
Sbjct: 1397 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT----ERQRGGAEGE 1452

Query: 162  GLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARERD 221
              +L  ++E A A +   Q  A  +      +      AE+E+ SR  +   ++ ARE+ 
Sbjct: 1453 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR--VKAEAEAAREKQ 1510

Query: 222  LGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELL 281
               Q L EL L+ E    R        A      L     +A+A+L+  R    EK   L
Sbjct: 1511 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1570

Query: 282  LDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRER-------AGRLPRLQE 334
               +  +Q     + +LR+EA+  + Q   AE  REEAE   ER       A RL    E
Sbjct: 1571 ---ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1627

Query: 335  ELRRCRERLQA-AEAYKSQLEEERVLSGVLEAS----KALLEEQLE--------AARERC 381
            E+ + +   QA AE  K + E E    G  E      + L E++LE         A++R 
Sbjct: 1628 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1687

Query: 382  ARLHETQRENLLLRTRLGEAHA-----ELDSLRHQVDQLAEENVELELELQR---SLEPP 433
            A   E  R  L   T  GE        EL  L+ +     ++  ELE EL +    +E  
Sbjct: 1688 AAEQELIR--LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1745

Query: 434  PGSPGEAPLAGAAPSLQDEVR-EAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAP 492
              S   A     + S + + R EAEAGR R L  E   LR L +             EA 
Sbjct: 1746 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE-------------EAK 1792

Query: 493  REDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPD 552
            R+  +    E+A +       + + L +K    G +A  L   A  ++ E  AE  +   
Sbjct: 1793 RQRQLAE--EDAARQRA---EAERVLAEKLAAIG-EATRLKTEAEIALKEKEAENERLRR 1846

Query: 553  SDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGT 612
                EA    Q   ++ QA+     +  + +E + +  +    S L+    +        
Sbjct: 1847 LAEDEA---FQRRRLEEQAA-----QHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1898

Query: 613  KIQAPQLLGGETEGREAPQG--ELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGL 670
            +    ++L  +    +A  G  EL  E   +R    +         S +  E E   Q  
Sbjct: 1899 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL------RSKEQAELEAARQRQ 1952

Query: 671  DLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE----GALEVQVWEGPIPGESLASGVAE 726
              A  +   RE ++R++ ++        Q+K+       L+ +V E     E      A 
Sbjct: 1953 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2012

Query: 727  QEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAA------RLSKELAQARRAEAEAH 780
            Q  L +E AQ R +AE        Q ++ E Q T         +L  E   ARRA  EA 
Sbjct: 2013 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA- 2071

Query: 781  REAEAQA-WEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQS 839
             EA  QA  E A+ R  VE A +  +SA ++ +A  +A AAA + R++ E+E +R     
Sbjct: 2072 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2131

Query: 840  EAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAA 899
            +AA  + Q  ++E  +H + AE+  R+K  ++ EL    ++ +E   +   L  EL++  
Sbjct: 2132 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2191

Query: 900  LERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGP 959
             E  E  R      QR Q  E+     +Q    SK +A +E + RAL L +         
Sbjct: 2192 AEATEAAR------QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD--------- 2236

Query: 960  AGLGPKKRAEPQL-VETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQEL 1018
                 K   +  L  E + ++ +  E +   + A++AA   QL   E  L   +  A+++
Sbjct: 2237 -----KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL--AEEDLAQQRALAEKM 2289

Query: 1019 LLQSQRAQEHSSRLQAEKSVLEIQ---GQELHRKLEVLEEEVRAARQSQEETRGQQQALL 1075
            L +  +A + ++RL+AE  +L+ Q    QE  R+L+  E++ + A+Q  EET+G Q+ L 
Sbjct: 2290 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ--EDKEQMAQQLAEETQGFQRTL- 2346

Query: 1076 RDHKALAQLQRRQEAELEGLLVRHRDL-KANMRALELAHRELQGRHEQLQAQRASVEAQE 1134
               +A  Q Q    AE E L +R  ++ +A  RA E              AQR   +A+E
Sbjct: 2347 ---EAERQRQLEMSAEAERLKLRVAEMSRAQARAEE-------------DAQRFRKQAEE 2390

Query: 1135 VALLAERERLMQDGHRQRGLEEELRRLQSEHD--RAQMLLAELSRERGELQGERGELRGR 1192
            +     R  L            E++R QS+HD  R +  +AEL RE+ +LQ E      +
Sbjct: 2391 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE-----AK 2445

Query: 1193 LARLELERAQLEMQSQQLRESN--QQLDLSACRLTTQCELL------------------- 1231
            L +L+ E  Q   Q Q L+E+   QQ  LS      Q E                     
Sbjct: 2446 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2505

Query: 1232 TQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKL 1291
             QLR  Q+ + +Q+  E Q L     E   R  E+ + + R+Q E L QL   RR++++L
Sbjct: 2506 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE-LQQLEQQRRQQEEL 2564

Query: 1292 V----EKIMDQYRVLE 1303
            +    +++ +Q ++LE
Sbjct: 2565 LAEENQRLREQLQLLE 2580



 Score =  159 bits (401), Expect = 2e-38
 Identities = 300/1197 (25%), Positives = 491/1197 (41%), Gaps = 217/1197 (18%)

Query: 193  DPGELAPAELEMLSR---SLMGTLSKLARERDLGAQ---RLAELLLEREPLCLRPEAPSR 246
            D G   P +  M  R   S      +L +  + GAQ   R    + E + + L+ EA   
Sbjct: 920  DAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACET 979

Query: 247  APAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALS 306
                   H L L L    A  R   Q + E+ +    +QAEV+GL   + RL  EA    
Sbjct: 980  RTV----HRLRLPLDKEPA--RECAQRIAEQQK----AQAEVEGLGKGVARLSAEA---- 1025

Query: 307  GQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKS-QLEEERVLSGVLEA 365
                      E+  AL E +   P L+ EL     +L+   +  +  LE+ + +S V+  
Sbjct: 1026 ----------EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1075

Query: 366  SKA------LLEEQLEAARERCARLHETQRENLLLRTRLGEAHAE---LDSLRHQV---- 412
            ++         EEQL+ A+   A L E +     L+    +A A+    D+LR ++    
Sbjct: 1076 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQ 1135

Query: 413  ---DQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENR 469
               ++L + + E ++E++R  E       +      A   Q +VR+      R LE+  R
Sbjct: 1136 EVGERLQQRHGERDVEVERWRE----RVAQLLERWQAVLAQTDVRQ------RELEQLGR 1185

Query: 470  ELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQA 529
            +LR   +                  DP+   L++A +        P    Q  R+   Q 
Sbjct: 1186 QLRYYRE----------------SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE 1229

Query: 530  LDLAPPALDSVLEASAECPQAPDS-----DPQEAESPLQAAAMDPQASDWSPQ--ESGSP 582
              L    ++   E   EC +            E +     A ++P AS       +SGS 
Sbjct: 1230 QALL-EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1288

Query: 583  VETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLR 642
               QE  +     S L +  S         K  +  L   E E R A Q           
Sbjct: 1289 SVIQEYVDLRTHYSELTTLTS------QYIKFISETLRRMEEEERLAEQ----------- 1331

Query: 643  QEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKS 702
            Q   E +      ++++ + Q         A  + EA+E  QR++        ++  ++ 
Sbjct: 1332 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--------EEVVRRE 1383

Query: 703  EGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEA 762
            E A++ Q                ++ +++EE+ QLR+ +EA   E++A+AR+ EA     
Sbjct: 1384 EAAVDAQ---------------QQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSR 1425

Query: 763  ARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAG 822
             R+ +E+   R       R+      E   LR   E A  +   A +E E L   +    
Sbjct: 1426 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1485

Query: 823  RERRQWERE-GSRLRAQSEAAEERMQVLES--EGRQHLEEAERERREKEALQAELEKAVV 879
            + +RQ E E  SR++A++EAA E+ + L++  E R   EEAER  R     QAE+E+A  
Sbjct: 1486 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVERA-- 1538

Query: 880  RGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQ------RLEAELQA---- 929
              +++   LE  QR  E     ++    EK +Q +R    E       R EAE +A    
Sbjct: 1539 --RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1596

Query: 930  -AATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNA 988
             A  ++EEA  EL+   L+  E L +LR     +  +K       E Q     E E    
Sbjct: 1597 EAERAREEAERELERWQLKANEAL-RLRLQAEEVAQQKSLAQAEAEKQKEE-AEREARRR 1654

Query: 989  MLVAEKAALQGQL--QHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQEL 1046
                E+A  Q +L  Q LE Q    +G AQ+ L     A++   RL+AE    E Q Q L
Sbjct: 1655 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL----AAEQELIRLRAETEQGEQQRQLL 1710

Query: 1047 HRKLEVLEEEVRAARQSQEE-------TRGQQQALLRDHKALAQLQRRQEAE-----LEG 1094
              +L  L+ E  AA Q ++E        R + + LL   KA A+ + R  +E     LE 
Sbjct: 1711 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS-KARAEEESRSTSEKSKQRLEA 1769

Query: 1095 LLVRHRDL---KANMRAL-ELAHRELQGRHEQLQAQRASVE---AQEVALLAERERLMQD 1147
               R R+L    A +RAL E A R+ Q   E    QRA  E   A+++A + E  RL  +
Sbjct: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1829

Query: 1148 GHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGE----RGELRGRLARL------E 1197
                   E  L+  ++E++R + L  + + +R  L+ +    + ++  RLA+L      E
Sbjct: 1830 A------EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1883

Query: 1198 LE------------RAQLEMQSQQLRES-------NQQLDLSACRLTTQCELLTQLRSAQ 1238
            LE            R Q+E +   L+ S         +L+L   R+ +  E    LRS +
Sbjct: 1884 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE--DTLRSKE 1941

Query: 1239 EEE-----NRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQK 1290
            + E      RQL AE +   RE  E +++SL + +   R+++  L+++  L+ + ++
Sbjct: 1942 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 1998



 Score =  154 bits (389), Expect = 6e-37
 Identities = 291/1222 (23%), Positives = 499/1222 (40%), Gaps = 233/1222 (19%)

Query: 269  RLRQELEEKAELLLDS---QAEVQGLEAEIRRLRQEAQALSGQAKRAELYREE------- 318
            R+ Q LE    +L  +   Q E++ L  ++R  R+ A  L    + A   +E+       
Sbjct: 1158 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1217

Query: 319  -AEALRERAGRLPRLQEELRRCRERLQAAE------------------AYKSQLE----- 354
             ++A+RE+  +   L EE+ R  E+++  +                   YK+QLE     
Sbjct: 1218 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1277

Query: 355  --EERVLSGVLEASK-------------ALLEEQLEAARERCARLHETQR----ENLLLR 395
              + +V SG     +              L  + ++   E   R+ E +R    +    R
Sbjct: 1278 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1337

Query: 396  TRLGEAHAELDSLRHQVDQLAEENVELE---LELQRSLEPPPGSPGEAPLAGAAP--SLQ 450
             RL E  A L+  R   +  A+   + E    ELQ+ ++       EA +       S+Q
Sbjct: 1338 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1397

Query: 451  DEVRE------------------AEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAP 492
            +E+++                  AE  RLR +E E R +R  L+  + Q GG    L+A 
Sbjct: 1398 EELQQLRQSSEAEIQAKARQAEAAERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQAL 1456

Query: 493  REDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECP---- 548
            R        EEA           + L ++ +D   Q    A   L S ++A AE      
Sbjct: 1457 RAR-----AEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQ 1510

Query: 549  -----------QAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQES--PEKAGRR 595
                       QA +++ +  ++ ++ A     A + + + + + ++++ +   EK  + 
Sbjct: 1511 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1570

Query: 596  SSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEP 655
                    VA  Q      +  Q        RE  + EL  E W L+          +E 
Sbjct: 1571 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL--ERWQLK---------ANEA 1619

Query: 656  SSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGA-----LEVQV 710
              ++L+ +E   Q   LA  +AE ++ +   E   R  A ++  ++ E A      + Q+
Sbjct: 1620 LRLRLQAEEVAQQ-KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1678

Query: 711  WEGPIPGESLA------------SGVAEQEALREEVAQLRRKAEAL---GDELEAQARKL 755
             EG       A             G  +++ L EE+A+L+R+A A      ELEA+  K+
Sbjct: 1679 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1738

Query: 756  EAQ---------NTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQ---- 802
             A+           E    S      +R EAEA R  E  A E ARLR   E A +    
Sbjct: 1739 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQL 1797

Query: 803  -ELESASQEREA---LVEALAAAGRERR----------QWEREGSRLRAQSEAAEERMQV 848
             E ++A Q  EA   L E LAA G   R          + E E  RLR  +E    + + 
Sbjct: 1798 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1857

Query: 849  LESEGRQH-------------------------LEEAERERREKE----ALQAELEKAVV 879
            LE +  QH                         +E+  R+RR+ E    AL+A  EKA  
Sbjct: 1858 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1917

Query: 880  RGKELGARL-------EHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQA--- 929
               EL   L       E   R  EQA LE     +    + +R +  E+R++  L A   
Sbjct: 1918 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1977

Query: 930  AATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAM 989
            AA  ++ AL E++    ++EE   +LR+       ++    Q  E    RL   E+++A 
Sbjct: 1978 AARQRKAALEEVERLKAKVEEAR-RLRERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF 2034

Query: 990  LVAEK-AALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHR 1048
             V +K   LQ  LQ  +  L  L+G A+     ++ A+E  +R+QAE+   + + Q    
Sbjct: 2035 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQSRRQ---- 2088

Query: 1049 KLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRA 1108
                  EE    +QS EE     QA  R     A  + R+EAE E    R +  +A +R 
Sbjct: 2089 -----VEEAERLKQSAEE-----QAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAALRQ 2137

Query: 1109 LELAHRELQGRHEQLQAQRASVEAQ-EVALLAERERLMQDGHRQRGLEEELRRLQSEHDR 1167
             + A  E++ +H++   Q    +AQ E  L   R +L +  H++  L+EEL+RL++E   
Sbjct: 2138 KQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2196

Query: 1168 AQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQS--------QQLRESNQQLDL 1219
            A    +++  E   ++ +  EL    AR+E E   L ++         Q+  E  +Q+  
Sbjct: 2197 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2256

Query: 1220 SACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERS--LESRDHLHREQREY 1277
             A RL+   +   +LR   EE+  Q  A  + + +E  + ++ +  L++   L ++Q+E 
Sbjct: 2257 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2316

Query: 1278 L-DQLNALRREKQKLVEKIMDQ 1298
              +Q   L+ +K+++ +++ ++
Sbjct: 2317 AQEQARRLQEDKEQMAQQLAEE 2338



 Score =  140 bits (353), Expect = 9e-33
 Identities = 259/1088 (23%), Positives = 436/1088 (40%), Gaps = 161/1088 (14%)

Query: 217  ARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEE 276
            A E+ +  + LAE  LE++       A  R  AE     L  +    + Q + L +EL  
Sbjct: 1657 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1716

Query: 277  KAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAE----------LYREEAEA----- 321
                   +  + Q LEAE+ ++R E + L     RAE            R EAEA     
Sbjct: 1717 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1776

Query: 322  LRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVL----EASKALLEEQL--- 374
            L E A RL  L EE +R R+ L   +A + + E ERVL+  L    EA++   E ++   
Sbjct: 1777 LAEEAARLRALAEEAKRQRQ-LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1835

Query: 375  --EAARERCARLHET---QRENLL---------LRTRLGEAHAELDSLRHQVDQLAEENV 420
              EA  ER  RL E    QR  L          +  RL +     DS   +   L E+ +
Sbjct: 1836 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1895

Query: 421  -------ELELELQRSLEPPPGSPGEAPL------AGAAPSLQD-EVREAEAGRLRTL-E 465
                   E  L L+ S E       E  L      + A  +L+  E  E EA R R L  
Sbjct: 1896 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1955

Query: 466  RENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDG 525
             E R  R   + +Q     +    EA R+      LEE  +     + + + L ++A   
Sbjct: 1956 EEERRRREAEERVQKSLAAEE---EAARQRKA--ALEEVERLKAKVEEA-RRLRERAEQE 2009

Query: 526  GPQALDLAPPALDSVLEASAECPQ-APDSDPQEAESPLQAAAMDPQASDWSPQESGSPVE 584
              + L LA  A    L+A  +    A     QE +  LQ    +    D    E+ +   
Sbjct: 2010 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ---QEQSVLDQLRGEAEAARR 2066

Query: 585  TQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQE 644
              E  E+A  ++  ++  S         +++  + L    E +   + +    A  LR+E
Sbjct: 2067 AAEEAEEARVQAEREAAQS-------RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2119

Query: 645  GPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE- 703
              +     ++     L +++            AE  +H +  E T+R    QK Q + E 
Sbjct: 2120 AEQEAARRAQAEQAALRQKQ---------AADAEMEKHKKFAEQTLR----QKAQVEQEL 2166

Query: 704  GALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAE-------ALGDELEAQARKLE 756
              L +Q+ E       L   +   +A   E A+ R + E          +EL     ++E
Sbjct: 2167 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2226

Query: 757  AQN--------TEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESAS 808
            A+N            R  +E A+  +  AE        A E ARLR+  E      E  +
Sbjct: 2227 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLA 2280

Query: 809  QEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEE----AERER 864
            Q+R AL E +    +E+ Q  +E +RL+A++E  +++ ++ + + R+  E+    A++  
Sbjct: 2281 QQR-ALAEKML---KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2336

Query: 865  REKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLE 924
             E +  Q  LE    R  E+ A  E L  +L  A + R +   E+++Q  R Q  E   +
Sbjct: 2337 EETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2394

Query: 925  AELQAAATSKEEALME-LKTRALQLEEELFQLRQGPAGLGPKK------------RAEPQ 971
                  AT ++  L++ L+ +  Q + +  +LR+  A L  +K            ++E  
Sbjct: 2395 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2454

Query: 972  LVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSR 1031
                Q   L E +      ++EK +L  + + +E +   L+   Q+ + ++Q+ +E   R
Sbjct: 2455 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2514

Query: 1032 LQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAE 1091
             Q +        QE  R +  +EE  R   +++E  R +Q+ L +      + QRRQ+ E
Sbjct: 2515 QQQQME------QERQRLVASMEEARRRQHEAEEGVRRKQEELQQ-----LEQQRRQQEE 2563

Query: 1092 LEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRA----------------SVEAQ-E 1134
            L  L   ++ L+  ++ LE  HR      E++ A +                 + EA+ E
Sbjct: 2564 L--LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2621

Query: 1135 VALLAERERLMQDGHRQRGL--EEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGR 1192
             +    R ++     ++ G+   EEL+RL   H      LA     R  LQG R  + G 
Sbjct: 2622 HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE-LARREDVRHYLQG-RSSIAGL 2679

Query: 1193 LARLELER 1200
            L +   E+
Sbjct: 2680 LLKATNEK 2687



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 148/629 (23%), Positives = 255/629 (40%), Gaps = 60/629 (9%)

Query: 716  PGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRA 775
            P    A  +AEQ+  + EV  L +    L  E E +   L   +  A  L  EL +    
Sbjct: 993  PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE-KVLALPEPSPAAPTLRSEL-ELTLG 1050

Query: 776  EAEAHREAEAQAWEQARLREAV---EAAGQELESASQEREALVEALAAAGRERRQWEREG 832
            + E  R   A   E+ +    V       +E+  A +E+    +A+ A   E    +   
Sbjct: 1051 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1110

Query: 833  SRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQ 892
             +LRAQ+EA +     L  E R   E  ER ++       E+E+   R  +L   LE  Q
Sbjct: 1111 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQ 1167

Query: 893  RELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEEL 952
              L Q  + RQ  L +   Q + Y+     L A LQ  A  ++E +  +     Q   E 
Sbjct: 1168 AVLAQTDV-RQRELEQLGRQLRYYRESADPLGAWLQ-DARRRQEQIQAMPLADSQAVRE- 1224

Query: 953  FQLRQGPAGLGPKKRAEPQLVETQNVR---LIEVERSNAMLVAEKAALQGQLQHLEGQLG 1009
             QLRQ  A L   +R   ++ E Q      +  ++     LV  KA L+        +  
Sbjct: 1225 -QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS--PAKKP 1281

Query: 1010 SLQGRAQELLLQSQRAQEHSSRLQAEKS-VLEIQGQELHRKLEVLEEEVRAARQSQEETR 1068
             +Q  ++ ++ +    + H S L    S  ++   + L R    +EEE R A Q + E R
Sbjct: 1282 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR----MEEEERLAEQQRAEER 1337

Query: 1069 ---GQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQA 1125
                + +A L   + LA+   + +A+ E      ++L+  M+  E+  RE      Q Q 
Sbjct: 1338 ERLAEVEAALEKQRQLAEAHAQAKAQAER---EAKELQQRMQE-EVVRREEAAVDAQQQK 1393

Query: 1126 QRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGE 1185
            +    E Q++   +E E +     +    E    R++ E    ++ L    R+RG  +GE
Sbjct: 1394 RSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1452

Query: 1186 RGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQL 1245
               LR R    E ++ Q + ++++LR                       R  Q+E  R+ 
Sbjct: 1453 LQALRARAEEAEAQKRQAQEEAERLR-----------------------RQVQDESQRKR 1489

Query: 1246 LAEVQALSRENREL-----LERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYR 1300
             AEV+  SR   E       +R+L++ + L  +  E   +L     E+ + V+  ++  +
Sbjct: 1490 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1549

Query: 1301 VLEPVPLPRTKKGSWLADKVKRLMRPRRE 1329
                  L ++K+ S+ A+K  +L R  +E
Sbjct: 1550 RSAEAEL-QSKRASF-AEKTAQLERSLQE 1576



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 131/567 (23%), Positives = 217/567 (38%), Gaps = 69/567 (12%)

Query: 694  AW-QKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAE-ALGDELEAQ 751
            AW ++ Q + +GA     W   +P  S+ + +     L + + + R K E A  DE +  
Sbjct: 508  AWVEENQHRVDGA----EWGVDLP--SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS 561

Query: 752  ARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQER 811
                 A      RL  + A+   +     R  E+       L   V AA +EL   +++ 
Sbjct: 562  PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES-------LHSFVAAATKELMWLNEKE 614

Query: 812  EALVEALAAAGRERRQWEREG-SRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEAL 870
            E  V    +        ++E  S L  + E  E++++ L++ G + L E    R   E+ 
Sbjct: 615  EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 674

Query: 871  QAELEKAVVRGKELGARLEHLQRELEQAALERQEF--LREKESQHQRYQ-GLEQRLEAEL 927
            QA L+       +L   +E     L++ A   Q F  +RE E Q Q+ Q  L ++   + 
Sbjct: 675  QAALQTQWSWMLQLCCCIE---AHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 731

Query: 928  QAAATSKEEALMELKTRALQLEEE------LFQLRQGPAGLGPKKRAEPQ-----LVETQ 976
             A  T  E+ L + +    QL E       L +  +    L P+  A P      L+   
Sbjct: 732  SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC 791

Query: 977  NVRLIEV---ERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQ 1033
            + + +EV   +     LV        ++    G   ++      +   +Q AQE  +RL+
Sbjct: 792  DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE 851

Query: 1034 AEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELE 1093
            A+   L     +LH  ++ L                  Q+L RD     QL R       
Sbjct: 852  AQHQALVTLWHQLHVDMKSLL---------------AWQSLRRD----VQLIRSWS---- 888

Query: 1094 GLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRG 1153
              L   R LK   +   L   EL  +     +Q A     E  L+AERE      H Q+ 
Sbjct: 889  --LATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQ- 945

Query: 1154 LEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELER------AQLEMQS 1207
            L + L +   E  R Q  ++EL   R +L+        RL RL L++      AQ   + 
Sbjct: 946  LLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL-RLPLDKEPARECAQRIAEQ 1004

Query: 1208 QQLRESNQQLDLSACRLTTQCELLTQL 1234
            Q+ +   + L     RL+ + E +  L
Sbjct: 1005 QKAQAEVEGLGKGVARLSAEAEKVLAL 1031


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  199 bits (505), Expect = 2e-50
 Identities = 333/1276 (26%), Positives = 533/1276 (41%), Gaps = 170/1276 (13%)

Query: 106  QEELQLLILSPPPDLQTLGFDPLSEEA----VEQLEGVLRLLLGASVQCEHRELFIRHIQ 161
            QEELQ L  S   ++Q       + E     +E+   V+RL L A+     R+      +
Sbjct: 1405 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT----ERQRGGAEGE 1460

Query: 162  GLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARERD 221
              +L  ++E A A +   Q  A  +      +      AE+E+ SR  +   ++ ARE+ 
Sbjct: 1461 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR--VKAEAEAAREKQ 1518

Query: 222  LGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELL 281
               Q L EL L+ E    R        A      L     +A+A+L+  R    EK   L
Sbjct: 1519 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1578

Query: 282  LDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRER-------AGRLPRLQE 334
               +  +Q     + +LR+EA+  + Q   AE  REEAE   ER       A RL    E
Sbjct: 1579 ---ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1635

Query: 335  ELRRCRERLQA-AEAYKSQLEEERVLSGVLEAS----KALLEEQLE--------AARERC 381
            E+ + +   QA AE  K + E E    G  E      + L E++LE         A++R 
Sbjct: 1636 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1695

Query: 382  ARLHETQRENLLLRTRLGEAHA-----ELDSLRHQVDQLAEENVELELELQR---SLEPP 433
            A   E  R  L   T  GE        EL  L+ +     ++  ELE EL +    +E  
Sbjct: 1696 AAEQELIR--LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1753

Query: 434  PGSPGEAPLAGAAPSLQDEVR-EAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAP 492
              S   A     + S + + R EAEAGR R L  E   LR L +             EA 
Sbjct: 1754 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE-------------EAK 1800

Query: 493  REDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPD 552
            R+  +    E+A +       + + L +K    G +A  L   A  ++ E  AE  +   
Sbjct: 1801 RQRQLAE--EDAARQRA---EAERVLAEKLAAIG-EATRLKTEAEIALKEKEAENERLRR 1854

Query: 553  SDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGT 612
                EA    Q   ++ QA+     +  + +E + +  +    S L+    +        
Sbjct: 1855 LAEDEA---FQRRRLEEQAA-----QHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1906

Query: 613  KIQAPQLLGGETEGREAPQG--ELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGL 670
            +    ++L  +    +A  G  EL  E   +R    +         S +  E E   Q  
Sbjct: 1907 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL------RSKEQAELEAARQRQ 1960

Query: 671  DLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE----GALEVQVWEGPIPGESLASGVAE 726
              A  +   RE ++R++ ++        Q+K+       L+ +V E     E      A 
Sbjct: 1961 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2020

Query: 727  QEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAA------RLSKELAQARRAEAEAH 780
            Q  L +E AQ R +AE        Q ++ E Q T         +L  E   ARRA  EA 
Sbjct: 2021 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA- 2079

Query: 781  REAEAQA-WEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQS 839
             EA  QA  E A+ R  VE A +  +SA ++ +A  +A AAA + R++ E+E +R     
Sbjct: 2080 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2139

Query: 840  EAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAA 899
            +AA  + Q  ++E  +H + AE+  R+K  ++ EL    ++ +E   +   L  EL++  
Sbjct: 2140 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2199

Query: 900  LERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGP 959
             E  E  R      QR Q  E+     +Q    SK +A +E + RAL L +         
Sbjct: 2200 AEATEAAR------QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD--------- 2244

Query: 960  AGLGPKKRAEPQL-VETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQEL 1018
                 K   +  L  E + ++ +  E +   + A++AA   QL   E  L   +  A+++
Sbjct: 2245 -----KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL--AEEDLAQQRALAEKM 2297

Query: 1019 LLQSQRAQEHSSRLQAEKSVLEIQ---GQELHRKLEVLEEEVRAARQSQEETRGQQQALL 1075
            L +  +A + ++RL+AE  +L+ Q    QE  R+L+  E++ + A+Q  EET+G Q+ L 
Sbjct: 2298 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ--EDKEQMAQQLAEETQGFQRTL- 2354

Query: 1076 RDHKALAQLQRRQEAELEGLLVRHRDL-KANMRALELAHRELQGRHEQLQAQRASVEAQE 1134
               +A  Q Q    AE E L +R  ++ +A  RA E              AQR   +A+E
Sbjct: 2355 ---EAERQRQLEMSAEAERLKLRVAEMSRAQARAEE-------------DAQRFRKQAEE 2398

Query: 1135 VALLAERERLMQDGHRQRGLEEELRRLQSEHD--RAQMLLAELSRERGELQGERGELRGR 1192
            +     R  L            E++R QS+HD  R +  +AEL RE+ +LQ E      +
Sbjct: 2399 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE-----AK 2453

Query: 1193 LARLELERAQLEMQSQQLRESN--QQLDLSACRLTTQCELL------------------- 1231
            L +L+ E  Q   Q Q L+E+   QQ  LS      Q E                     
Sbjct: 2454 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2513

Query: 1232 TQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKL 1291
             QLR  Q+ + +Q+  E Q L     E   R  E+ + + R+Q E L QL   RR++++L
Sbjct: 2514 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE-LQQLEQQRRQQEEL 2572

Query: 1292 V----EKIMDQYRVLE 1303
            +    +++ +Q ++LE
Sbjct: 2573 LAEENQRLREQLQLLE 2588



 Score =  159 bits (401), Expect = 2e-38
 Identities = 300/1197 (25%), Positives = 491/1197 (41%), Gaps = 217/1197 (18%)

Query: 193  DPGELAPAELEMLSR---SLMGTLSKLARERDLGAQ---RLAELLLEREPLCLRPEAPSR 246
            D G   P +  M  R   S      +L +  + GAQ   R    + E + + L+ EA   
Sbjct: 928  DAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACET 987

Query: 247  APAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALS 306
                   H L L L    A  R   Q + E+ +    +QAEV+GL   + RL  EA    
Sbjct: 988  RTV----HRLRLPLDKEPA--RECAQRIAEQQK----AQAEVEGLGKGVARLSAEA---- 1033

Query: 307  GQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKS-QLEEERVLSGVLEA 365
                      E+  AL E +   P L+ EL     +L+   +  +  LE+ + +S V+  
Sbjct: 1034 ----------EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1083

Query: 366  SKA------LLEEQLEAARERCARLHETQRENLLLRTRLGEAHAE---LDSLRHQV---- 412
            ++         EEQL+ A+   A L E +     L+    +A A+    D+LR ++    
Sbjct: 1084 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQ 1143

Query: 413  ---DQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENR 469
               ++L + + E ++E++R  E       +      A   Q +VR+      R LE+  R
Sbjct: 1144 EVGERLQQRHGERDVEVERWRE----RVAQLLERWQAVLAQTDVRQ------RELEQLGR 1193

Query: 470  ELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQA 529
            +LR   +                  DP+   L++A +        P    Q  R+   Q 
Sbjct: 1194 QLRYYRE----------------SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE 1237

Query: 530  LDLAPPALDSVLEASAECPQAPDS-----DPQEAESPLQAAAMDPQASDWSPQ--ESGSP 582
              L    ++   E   EC +            E +     A ++P AS       +SGS 
Sbjct: 1238 QALL-EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1296

Query: 583  VETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLR 642
               QE  +     S L +  S         K  +  L   E E R A Q           
Sbjct: 1297 SVIQEYVDLRTHYSELTTLTS------QYIKFISETLRRMEEEERLAEQ----------- 1339

Query: 643  QEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKS 702
            Q   E +      ++++ + Q         A  + EA+E  QR++        ++  ++ 
Sbjct: 1340 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--------EEVVRRE 1391

Query: 703  EGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEA 762
            E A++ Q                ++ +++EE+ QLR+ +EA   E++A+AR+ EA     
Sbjct: 1392 EAAVDAQ---------------QQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSR 1433

Query: 763  ARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAG 822
             R+ +E+   R       R+      E   LR   E A  +   A +E E L   +    
Sbjct: 1434 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1493

Query: 823  RERRQWERE-GSRLRAQSEAAEERMQVLES--EGRQHLEEAERERREKEALQAELEKAVV 879
            + +RQ E E  SR++A++EAA E+ + L++  E R   EEAER  R     QAE+E+A  
Sbjct: 1494 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVERA-- 1546

Query: 880  RGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQ------RLEAELQA---- 929
              +++   LE  QR  E     ++    EK +Q +R    E       R EAE +A    
Sbjct: 1547 --RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1604

Query: 930  -AATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNA 988
             A  ++EEA  EL+   L+  E L +LR     +  +K       E Q     E E    
Sbjct: 1605 EAERAREEAERELERWQLKANEAL-RLRLQAEEVAQQKSLAQAEAEKQKEE-AEREARRR 1662

Query: 989  MLVAEKAALQGQL--QHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQEL 1046
                E+A  Q +L  Q LE Q    +G AQ+ L     A++   RL+AE    E Q Q L
Sbjct: 1663 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL----AAEQELIRLRAETEQGEQQRQLL 1718

Query: 1047 HRKLEVLEEEVRAARQSQEE-------TRGQQQALLRDHKALAQLQRRQEAE-----LEG 1094
              +L  L+ E  AA Q ++E        R + + LL   KA A+ + R  +E     LE 
Sbjct: 1719 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS-KARAEEESRSTSEKSKQRLEA 1777

Query: 1095 LLVRHRDL---KANMRAL-ELAHRELQGRHEQLQAQRASVE---AQEVALLAERERLMQD 1147
               R R+L    A +RAL E A R+ Q   E    QRA  E   A+++A + E  RL  +
Sbjct: 1778 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1837

Query: 1148 GHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGE----RGELRGRLARL------E 1197
                   E  L+  ++E++R + L  + + +R  L+ +    + ++  RLA+L      E
Sbjct: 1838 A------EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1891

Query: 1198 LE------------RAQLEMQSQQLRES-------NQQLDLSACRLTTQCELLTQLRSAQ 1238
            LE            R Q+E +   L+ S         +L+L   R+ +  E    LRS +
Sbjct: 1892 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE--DTLRSKE 1949

Query: 1239 EEE-----NRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQK 1290
            + E      RQL AE +   RE  E +++SL + +   R+++  L+++  L+ + ++
Sbjct: 1950 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2006



 Score =  154 bits (389), Expect = 6e-37
 Identities = 291/1222 (23%), Positives = 499/1222 (40%), Gaps = 233/1222 (19%)

Query: 269  RLRQELEEKAELLLDS---QAEVQGLEAEIRRLRQEAQALSGQAKRAELYREE------- 318
            R+ Q LE    +L  +   Q E++ L  ++R  R+ A  L    + A   +E+       
Sbjct: 1166 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1225

Query: 319  -AEALRERAGRLPRLQEELRRCRERLQAAE------------------AYKSQLE----- 354
             ++A+RE+  +   L EE+ R  E+++  +                   YK+QLE     
Sbjct: 1226 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1285

Query: 355  --EERVLSGVLEASK-------------ALLEEQLEAARERCARLHETQR----ENLLLR 395
              + +V SG     +              L  + ++   E   R+ E +R    +    R
Sbjct: 1286 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1345

Query: 396  TRLGEAHAELDSLRHQVDQLAEENVELE---LELQRSLEPPPGSPGEAPLAGAAP--SLQ 450
             RL E  A L+  R   +  A+   + E    ELQ+ ++       EA +       S+Q
Sbjct: 1346 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1405

Query: 451  DEVRE------------------AEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAP 492
            +E+++                  AE  RLR +E E R +R  L+  + Q GG    L+A 
Sbjct: 1406 EELQQLRQSSEAEIQAKARQAEAAERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQAL 1464

Query: 493  REDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECP---- 548
            R        EEA           + L ++ +D   Q    A   L S ++A AE      
Sbjct: 1465 RAR-----AEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQ 1518

Query: 549  -----------QAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQES--PEKAGRR 595
                       QA +++ +  ++ ++ A     A + + + + + ++++ +   EK  + 
Sbjct: 1519 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1578

Query: 596  SSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEP 655
                    VA  Q      +  Q        RE  + EL  E W L+          +E 
Sbjct: 1579 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL--ERWQLK---------ANEA 1627

Query: 656  SSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGA-----LEVQV 710
              ++L+ +E   Q   LA  +AE ++ +   E   R  A ++  ++ E A      + Q+
Sbjct: 1628 LRLRLQAEEVAQQ-KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1686

Query: 711  WEGPIPGESLA------------SGVAEQEALREEVAQLRRKAEAL---GDELEAQARKL 755
             EG       A             G  +++ L EE+A+L+R+A A      ELEA+  K+
Sbjct: 1687 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1746

Query: 756  EAQ---------NTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQ---- 802
             A+           E    S      +R EAEA R  E  A E ARLR   E A +    
Sbjct: 1747 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQL 1805

Query: 803  -ELESASQEREA---LVEALAAAGRERR----------QWEREGSRLRAQSEAAEERMQV 848
             E ++A Q  EA   L E LAA G   R          + E E  RLR  +E    + + 
Sbjct: 1806 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1865

Query: 849  LESEGRQH-------------------------LEEAERERREKE----ALQAELEKAVV 879
            LE +  QH                         +E+  R+RR+ E    AL+A  EKA  
Sbjct: 1866 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1925

Query: 880  RGKELGARL-------EHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQA--- 929
               EL   L       E   R  EQA LE     +    + +R +  E+R++  L A   
Sbjct: 1926 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1985

Query: 930  AATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAM 989
            AA  ++ AL E++    ++EE   +LR+       ++    Q  E    RL   E+++A 
Sbjct: 1986 AARQRKAALEEVERLKAKVEEAR-RLRERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF 2042

Query: 990  LVAEK-AALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHR 1048
             V +K   LQ  LQ  +  L  L+G A+     ++ A+E  +R+QAE+   + + Q    
Sbjct: 2043 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQSRRQ---- 2096

Query: 1049 KLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRA 1108
                  EE    +QS EE     QA  R     A  + R+EAE E    R +  +A +R 
Sbjct: 2097 -----VEEAERLKQSAEE-----QAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAALRQ 2145

Query: 1109 LELAHRELQGRHEQLQAQRASVEAQ-EVALLAERERLMQDGHRQRGLEEELRRLQSEHDR 1167
             + A  E++ +H++   Q    +AQ E  L   R +L +  H++  L+EEL+RL++E   
Sbjct: 2146 KQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2204

Query: 1168 AQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQS--------QQLRESNQQLDL 1219
            A    +++  E   ++ +  EL    AR+E E   L ++         Q+  E  +Q+  
Sbjct: 2205 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2264

Query: 1220 SACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERS--LESRDHLHREQREY 1277
             A RL+   +   +LR   EE+  Q  A  + + +E  + ++ +  L++   L ++Q+E 
Sbjct: 2265 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2324

Query: 1278 L-DQLNALRREKQKLVEKIMDQ 1298
              +Q   L+ +K+++ +++ ++
Sbjct: 2325 AQEQARRLQEDKEQMAQQLAEE 2346



 Score =  140 bits (353), Expect = 9e-33
 Identities = 259/1088 (23%), Positives = 436/1088 (40%), Gaps = 161/1088 (14%)

Query: 217  ARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEE 276
            A E+ +  + LAE  LE++       A  R  AE     L  +    + Q + L +EL  
Sbjct: 1665 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1724

Query: 277  KAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAE----------LYREEAEA----- 321
                   +  + Q LEAE+ ++R E + L     RAE            R EAEA     
Sbjct: 1725 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1784

Query: 322  LRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVL----EASKALLEEQL--- 374
            L E A RL  L EE +R R+ L   +A + + E ERVL+  L    EA++   E ++   
Sbjct: 1785 LAEEAARLRALAEEAKRQRQ-LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1843

Query: 375  --EAARERCARLHET---QRENLL---------LRTRLGEAHAELDSLRHQVDQLAEENV 420
              EA  ER  RL E    QR  L          +  RL +     DS   +   L E+ +
Sbjct: 1844 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1903

Query: 421  -------ELELELQRSLEPPPGSPGEAPL------AGAAPSLQD-EVREAEAGRLRTL-E 465
                   E  L L+ S E       E  L      + A  +L+  E  E EA R R L  
Sbjct: 1904 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1963

Query: 466  RENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDG 525
             E R  R   + +Q     +    EA R+      LEE  +     + + + L ++A   
Sbjct: 1964 EEERRRREAEERVQKSLAAEE---EAARQRKA--ALEEVERLKAKVEEA-RRLRERAEQE 2017

Query: 526  GPQALDLAPPALDSVLEASAECPQ-APDSDPQEAESPLQAAAMDPQASDWSPQESGSPVE 584
              + L LA  A    L+A  +    A     QE +  LQ    +    D    E+ +   
Sbjct: 2018 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ---QEQSVLDQLRGEAEAARR 2074

Query: 585  TQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQE 644
              E  E+A  ++  ++  S         +++  + L    E +   + +    A  LR+E
Sbjct: 2075 AAEEAEEARVQAEREAAQS-------RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2127

Query: 645  GPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE- 703
              +     ++     L +++            AE  +H +  E T+R    QK Q + E 
Sbjct: 2128 AEQEAARRAQAEQAALRQKQ---------AADAEMEKHKKFAEQTLR----QKAQVEQEL 2174

Query: 704  GALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAE-------ALGDELEAQARKLE 756
              L +Q+ E       L   +   +A   E A+ R + E          +EL     ++E
Sbjct: 2175 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2234

Query: 757  AQN--------TEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESAS 808
            A+N            R  +E A+  +  AE        A E ARLR+  E      E  +
Sbjct: 2235 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLA 2288

Query: 809  QEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEE----AERER 864
            Q+R AL E +    +E+ Q  +E +RL+A++E  +++ ++ + + R+  E+    A++  
Sbjct: 2289 QQR-ALAEKML---KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2344

Query: 865  REKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLE 924
             E +  Q  LE    R  E+ A  E L  +L  A + R +   E+++Q  R Q  E   +
Sbjct: 2345 EETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2402

Query: 925  AELQAAATSKEEALME-LKTRALQLEEELFQLRQGPAGLGPKK------------RAEPQ 971
                  AT ++  L++ L+ +  Q + +  +LR+  A L  +K            ++E  
Sbjct: 2403 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2462

Query: 972  LVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSR 1031
                Q   L E +      ++EK +L  + + +E +   L+   Q+ + ++Q+ +E   R
Sbjct: 2463 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2522

Query: 1032 LQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAE 1091
             Q +        QE  R +  +EE  R   +++E  R +Q+ L +      + QRRQ+ E
Sbjct: 2523 QQQQME------QERQRLVASMEEARRRQHEAEEGVRRKQEELQQ-----LEQQRRQQEE 2571

Query: 1092 LEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRA----------------SVEAQ-E 1134
            L  L   ++ L+  ++ LE  HR      E++ A +                 + EA+ E
Sbjct: 2572 L--LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2629

Query: 1135 VALLAERERLMQDGHRQRGL--EEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGR 1192
             +    R ++     ++ G+   EEL+RL   H      LA     R  LQG R  + G 
Sbjct: 2630 HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE-LARREDVRHYLQG-RSSIAGL 2687

Query: 1193 LARLELER 1200
            L +   E+
Sbjct: 2688 LLKATNEK 2695



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 148/629 (23%), Positives = 255/629 (40%), Gaps = 60/629 (9%)

Query: 716  PGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRA 775
            P    A  +AEQ+  + EV  L +    L  E E +   L   +  A  L  EL +    
Sbjct: 1001 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE-KVLALPEPSPAAPTLRSEL-ELTLG 1058

Query: 776  EAEAHREAEAQAWEQARLREAV---EAAGQELESASQEREALVEALAAAGRERRQWEREG 832
            + E  R   A   E+ +    V       +E+  A +E+    +A+ A   E    +   
Sbjct: 1059 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1118

Query: 833  SRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQ 892
             +LRAQ+EA +     L  E R   E  ER ++       E+E+   R  +L   LE  Q
Sbjct: 1119 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQ 1175

Query: 893  RELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEEL 952
              L Q  + RQ  L +   Q + Y+     L A LQ  A  ++E +  +     Q   E 
Sbjct: 1176 AVLAQTDV-RQRELEQLGRQLRYYRESADPLGAWLQ-DARRRQEQIQAMPLADSQAVRE- 1232

Query: 953  FQLRQGPAGLGPKKRAEPQLVETQNVR---LIEVERSNAMLVAEKAALQGQLQHLEGQLG 1009
             QLRQ  A L   +R   ++ E Q      +  ++     LV  KA L+        +  
Sbjct: 1233 -QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS--PAKKP 1289

Query: 1010 SLQGRAQELLLQSQRAQEHSSRLQAEKS-VLEIQGQELHRKLEVLEEEVRAARQSQEETR 1068
             +Q  ++ ++ +    + H S L    S  ++   + L R    +EEE R A Q + E R
Sbjct: 1290 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR----MEEEERLAEQQRAEER 1345

Query: 1069 ---GQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQA 1125
                + +A L   + LA+   + +A+ E      ++L+  M+  E+  RE      Q Q 
Sbjct: 1346 ERLAEVEAALEKQRQLAEAHAQAKAQAER---EAKELQQRMQE-EVVRREEAAVDAQQQK 1401

Query: 1126 QRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGE 1185
            +    E Q++   +E E +     +    E    R++ E    ++ L    R+RG  +GE
Sbjct: 1402 RSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1460

Query: 1186 RGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQL 1245
               LR R    E ++ Q + ++++LR                       R  Q+E  R+ 
Sbjct: 1461 LQALRARAEEAEAQKRQAQEEAERLR-----------------------RQVQDESQRKR 1497

Query: 1246 LAEVQALSRENREL-----LERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYR 1300
             AEV+  SR   E       +R+L++ + L  +  E   +L     E+ + V+  ++  +
Sbjct: 1498 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1557

Query: 1301 VLEPVPLPRTKKGSWLADKVKRLMRPRRE 1329
                  L ++K+ S+ A+K  +L R  +E
Sbjct: 1558 RSAEAEL-QSKRASF-AEKTAQLERSLQE 1584



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 131/567 (23%), Positives = 217/567 (38%), Gaps = 69/567 (12%)

Query: 694  AW-QKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAE-ALGDELEAQ 751
            AW ++ Q + +GA     W   +P  S+ + +     L + + + R K E A  DE +  
Sbjct: 516  AWVEENQHRVDGA----EWGVDLP--SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS 569

Query: 752  ARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQER 811
                 A      RL  + A+   +     R  E+       L   V AA +EL   +++ 
Sbjct: 570  PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES-------LHSFVAAATKELMWLNEKE 622

Query: 812  EALVEALAAAGRERRQWEREG-SRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEAL 870
            E  V    +        ++E  S L  + E  E++++ L++ G + L E    R   E+ 
Sbjct: 623  EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 682

Query: 871  QAELEKAVVRGKELGARLEHLQRELEQAALERQEF--LREKESQHQRYQ-GLEQRLEAEL 927
            QA L+       +L   +E     L++ A   Q F  +RE E Q Q+ Q  L ++   + 
Sbjct: 683  QAALQTQWSWMLQLCCCIE---AHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 739

Query: 928  QAAATSKEEALMELKTRALQLEEE------LFQLRQGPAGLGPKKRAEPQ-----LVETQ 976
             A  T  E+ L + +    QL E       L +  +    L P+  A P      L+   
Sbjct: 740  SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC 799

Query: 977  NVRLIEV---ERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQ 1033
            + + +EV   +     LV        ++    G   ++      +   +Q AQE  +RL+
Sbjct: 800  DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE 859

Query: 1034 AEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELE 1093
            A+   L     +LH  ++ L                  Q+L RD     QL R       
Sbjct: 860  AQHQALVTLWHQLHVDMKSLL---------------AWQSLRRD----VQLIRSWS---- 896

Query: 1094 GLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRG 1153
              L   R LK   +   L   EL  +     +Q A     E  L+AERE      H Q+ 
Sbjct: 897  --LATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQ- 953

Query: 1154 LEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELER------AQLEMQS 1207
            L + L +   E  R Q  ++EL   R +L+        RL RL L++      AQ   + 
Sbjct: 954  LLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL-RLPLDKEPARECAQRIAEQ 1012

Query: 1208 QQLRESNQQLDLSACRLTTQCELLTQL 1234
            Q+ +   + L     RL+ + E +  L
Sbjct: 1013 QKAQAEVEGLGKGVARLSAEAEKVLAL 1039


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  199 bits (505), Expect = 2e-50
 Identities = 333/1276 (26%), Positives = 533/1276 (41%), Gaps = 170/1276 (13%)

Query: 106  QEELQLLILSPPPDLQTLGFDPLSEEA----VEQLEGVLRLLLGASVQCEHRELFIRHIQ 161
            QEELQ L  S   ++Q       + E     +E+   V+RL L A+     R+      +
Sbjct: 1446 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT----ERQRGGAEGE 1501

Query: 162  GLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARERD 221
              +L  ++E A A +   Q  A  +      +      AE+E+ SR  +   ++ ARE+ 
Sbjct: 1502 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR--VKAEAEAAREKQ 1559

Query: 222  LGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELL 281
               Q L EL L+ E    R        A      L     +A+A+L+  R    EK   L
Sbjct: 1560 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1619

Query: 282  LDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRER-------AGRLPRLQE 334
               +  +Q     + +LR+EA+  + Q   AE  REEAE   ER       A RL    E
Sbjct: 1620 ---ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1676

Query: 335  ELRRCRERLQA-AEAYKSQLEEERVLSGVLEAS----KALLEEQLE--------AARERC 381
            E+ + +   QA AE  K + E E    G  E      + L E++LE         A++R 
Sbjct: 1677 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1736

Query: 382  ARLHETQRENLLLRTRLGEAHA-----ELDSLRHQVDQLAEENVELELELQR---SLEPP 433
            A   E  R  L   T  GE        EL  L+ +     ++  ELE EL +    +E  
Sbjct: 1737 AAEQELIR--LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1794

Query: 434  PGSPGEAPLAGAAPSLQDEVR-EAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAP 492
              S   A     + S + + R EAEAGR R L  E   LR L +             EA 
Sbjct: 1795 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE-------------EAK 1841

Query: 493  REDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPD 552
            R+  +    E+A +       + + L +K    G +A  L   A  ++ E  AE  +   
Sbjct: 1842 RQRQLAE--EDAARQRA---EAERVLAEKLAAIG-EATRLKTEAEIALKEKEAENERLRR 1895

Query: 553  SDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGT 612
                EA    Q   ++ QA+     +  + +E + +  +    S L+    +        
Sbjct: 1896 LAEDEA---FQRRRLEEQAA-----QHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1947

Query: 613  KIQAPQLLGGETEGREAPQG--ELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGL 670
            +    ++L  +    +A  G  EL  E   +R    +         S +  E E   Q  
Sbjct: 1948 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL------RSKEQAELEAARQRQ 2001

Query: 671  DLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE----GALEVQVWEGPIPGESLASGVAE 726
              A  +   RE ++R++ ++        Q+K+       L+ +V E     E      A 
Sbjct: 2002 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2061

Query: 727  QEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAA------RLSKELAQARRAEAEAH 780
            Q  L +E AQ R +AE        Q ++ E Q T         +L  E   ARRA  EA 
Sbjct: 2062 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA- 2120

Query: 781  REAEAQA-WEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQS 839
             EA  QA  E A+ R  VE A +  +SA ++ +A  +A AAA + R++ E+E +R     
Sbjct: 2121 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2180

Query: 840  EAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAA 899
            +AA  + Q  ++E  +H + AE+  R+K  ++ EL    ++ +E   +   L  EL++  
Sbjct: 2181 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2240

Query: 900  LERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGP 959
             E  E  R      QR Q  E+     +Q    SK +A +E + RAL L +         
Sbjct: 2241 AEATEAAR------QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD--------- 2285

Query: 960  AGLGPKKRAEPQL-VETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQEL 1018
                 K   +  L  E + ++ +  E +   + A++AA   QL   E  L   +  A+++
Sbjct: 2286 -----KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL--AEEDLAQQRALAEKM 2338

Query: 1019 LLQSQRAQEHSSRLQAEKSVLEIQ---GQELHRKLEVLEEEVRAARQSQEETRGQQQALL 1075
            L +  +A + ++RL+AE  +L+ Q    QE  R+L+  E++ + A+Q  EET+G Q+ L 
Sbjct: 2339 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ--EDKEQMAQQLAEETQGFQRTL- 2395

Query: 1076 RDHKALAQLQRRQEAELEGLLVRHRDL-KANMRALELAHRELQGRHEQLQAQRASVEAQE 1134
               +A  Q Q    AE E L +R  ++ +A  RA E              AQR   +A+E
Sbjct: 2396 ---EAERQRQLEMSAEAERLKLRVAEMSRAQARAEE-------------DAQRFRKQAEE 2439

Query: 1135 VALLAERERLMQDGHRQRGLEEELRRLQSEHD--RAQMLLAELSRERGELQGERGELRGR 1192
            +     R  L            E++R QS+HD  R +  +AEL RE+ +LQ E      +
Sbjct: 2440 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE-----AK 2494

Query: 1193 LARLELERAQLEMQSQQLRESN--QQLDLSACRLTTQCELL------------------- 1231
            L +L+ E  Q   Q Q L+E+   QQ  LS      Q E                     
Sbjct: 2495 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2554

Query: 1232 TQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKL 1291
             QLR  Q+ + +Q+  E Q L     E   R  E+ + + R+Q E L QL   RR++++L
Sbjct: 2555 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE-LQQLEQQRRQQEEL 2613

Query: 1292 V----EKIMDQYRVLE 1303
            +    +++ +Q ++LE
Sbjct: 2614 LAEENQRLREQLQLLE 2629



 Score =  159 bits (401), Expect = 2e-38
 Identities = 300/1197 (25%), Positives = 491/1197 (41%), Gaps = 217/1197 (18%)

Query: 193  DPGELAPAELEMLSR---SLMGTLSKLARERDLGAQ---RLAELLLEREPLCLRPEAPSR 246
            D G   P +  M  R   S      +L +  + GAQ   R    + E + + L+ EA   
Sbjct: 969  DAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACET 1028

Query: 247  APAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALS 306
                   H L L L    A  R   Q + E+ +    +QAEV+GL   + RL  EA    
Sbjct: 1029 RTV----HRLRLPLDKEPA--RECAQRIAEQQK----AQAEVEGLGKGVARLSAEA---- 1074

Query: 307  GQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKS-QLEEERVLSGVLEA 365
                      E+  AL E +   P L+ EL     +L+   +  +  LE+ + +S V+  
Sbjct: 1075 ----------EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1124

Query: 366  SKA------LLEEQLEAARERCARLHETQRENLLLRTRLGEAHAE---LDSLRHQV---- 412
            ++         EEQL+ A+   A L E +     L+    +A A+    D+LR ++    
Sbjct: 1125 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQ 1184

Query: 413  ---DQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENR 469
               ++L + + E ++E++R  E       +      A   Q +VR+      R LE+  R
Sbjct: 1185 EVGERLQQRHGERDVEVERWRE----RVAQLLERWQAVLAQTDVRQ------RELEQLGR 1234

Query: 470  ELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQA 529
            +LR   +                  DP+   L++A +        P    Q  R+   Q 
Sbjct: 1235 QLRYYRE----------------SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE 1278

Query: 530  LDLAPPALDSVLEASAECPQAPDS-----DPQEAESPLQAAAMDPQASDWSPQ--ESGSP 582
              L    ++   E   EC +            E +     A ++P AS       +SGS 
Sbjct: 1279 QALL-EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1337

Query: 583  VETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLR 642
               QE  +     S L +  S         K  +  L   E E R A Q           
Sbjct: 1338 SVIQEYVDLRTHYSELTTLTS------QYIKFISETLRRMEEEERLAEQ----------- 1380

Query: 643  QEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKS 702
            Q   E +      ++++ + Q         A  + EA+E  QR++        ++  ++ 
Sbjct: 1381 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ--------EEVVRRE 1432

Query: 703  EGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEA 762
            E A++ Q                ++ +++EE+ QLR+ +EA   E++A+AR+ EA     
Sbjct: 1433 EAAVDAQ---------------QQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSR 1474

Query: 763  ARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAG 822
             R+ +E+   R       R+      E   LR   E A  +   A +E E L   +    
Sbjct: 1475 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1534

Query: 823  RERRQWERE-GSRLRAQSEAAEERMQVLES--EGRQHLEEAERERREKEALQAELEKAVV 879
            + +RQ E E  SR++A++EAA E+ + L++  E R   EEAER  R     QAE+E+A  
Sbjct: 1535 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVERA-- 1587

Query: 880  RGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQ------RLEAELQA---- 929
              +++   LE  QR  E     ++    EK +Q +R    E       R EAE +A    
Sbjct: 1588 --RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1645

Query: 930  -AATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNA 988
             A  ++EEA  EL+   L+  E L +LR     +  +K       E Q     E E    
Sbjct: 1646 EAERAREEAERELERWQLKANEAL-RLRLQAEEVAQQKSLAQAEAEKQKEE-AEREARRR 1703

Query: 989  MLVAEKAALQGQL--QHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQEL 1046
                E+A  Q +L  Q LE Q    +G AQ+ L     A++   RL+AE    E Q Q L
Sbjct: 1704 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL----AAEQELIRLRAETEQGEQQRQLL 1759

Query: 1047 HRKLEVLEEEVRAARQSQEE-------TRGQQQALLRDHKALAQLQRRQEAE-----LEG 1094
              +L  L+ E  AA Q ++E        R + + LL   KA A+ + R  +E     LE 
Sbjct: 1760 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS-KARAEEESRSTSEKSKQRLEA 1818

Query: 1095 LLVRHRDL---KANMRAL-ELAHRELQGRHEQLQAQRASVE---AQEVALLAERERLMQD 1147
               R R+L    A +RAL E A R+ Q   E    QRA  E   A+++A + E  RL  +
Sbjct: 1819 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1878

Query: 1148 GHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGE----RGELRGRLARL------E 1197
                   E  L+  ++E++R + L  + + +R  L+ +    + ++  RLA+L      E
Sbjct: 1879 A------EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1932

Query: 1198 LE------------RAQLEMQSQQLRES-------NQQLDLSACRLTTQCELLTQLRSAQ 1238
            LE            R Q+E +   L+ S         +L+L   R+ +  E    LRS +
Sbjct: 1933 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE--DTLRSKE 1990

Query: 1239 EEE-----NRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQK 1290
            + E      RQL AE +   RE  E +++SL + +   R+++  L+++  L+ + ++
Sbjct: 1991 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2047



 Score =  154 bits (389), Expect = 6e-37
 Identities = 291/1222 (23%), Positives = 499/1222 (40%), Gaps = 233/1222 (19%)

Query: 269  RLRQELEEKAELLLDS---QAEVQGLEAEIRRLRQEAQALSGQAKRAELYREE------- 318
            R+ Q LE    +L  +   Q E++ L  ++R  R+ A  L    + A   +E+       
Sbjct: 1207 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1266

Query: 319  -AEALRERAGRLPRLQEELRRCRERLQAAE------------------AYKSQLE----- 354
             ++A+RE+  +   L EE+ R  E+++  +                   YK+QLE     
Sbjct: 1267 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1326

Query: 355  --EERVLSGVLEASK-------------ALLEEQLEAARERCARLHETQR----ENLLLR 395
              + +V SG     +              L  + ++   E   R+ E +R    +    R
Sbjct: 1327 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1386

Query: 396  TRLGEAHAELDSLRHQVDQLAEENVELE---LELQRSLEPPPGSPGEAPLAGAAP--SLQ 450
             RL E  A L+  R   +  A+   + E    ELQ+ ++       EA +       S+Q
Sbjct: 1387 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1446

Query: 451  DEVRE------------------AEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAP 492
            +E+++                  AE  RLR +E E R +R  L+  + Q GG    L+A 
Sbjct: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQAL 1505

Query: 493  REDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECP---- 548
            R        EEA           + L ++ +D   Q    A   L S ++A AE      
Sbjct: 1506 RAR-----AEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQ 1559

Query: 549  -----------QAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQES--PEKAGRR 595
                       QA +++ +  ++ ++ A     A + + + + + ++++ +   EK  + 
Sbjct: 1560 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1619

Query: 596  SSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEP 655
                    VA  Q      +  Q        RE  + EL  E W L+          +E 
Sbjct: 1620 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL--ERWQLK---------ANEA 1668

Query: 656  SSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGA-----LEVQV 710
              ++L+ +E   Q   LA  +AE ++ +   E   R  A ++  ++ E A      + Q+
Sbjct: 1669 LRLRLQAEEVAQQ-KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1727

Query: 711  WEGPIPGESLA------------SGVAEQEALREEVAQLRRKAEAL---GDELEAQARKL 755
             EG       A             G  +++ L EE+A+L+R+A A      ELEA+  K+
Sbjct: 1728 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1787

Query: 756  EAQ---------NTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQ---- 802
             A+           E    S      +R EAEA R  E  A E ARLR   E A +    
Sbjct: 1788 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQL 1846

Query: 803  -ELESASQEREA---LVEALAAAGRERR----------QWEREGSRLRAQSEAAEERMQV 848
             E ++A Q  EA   L E LAA G   R          + E E  RLR  +E    + + 
Sbjct: 1847 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1906

Query: 849  LESEGRQH-------------------------LEEAERERREKE----ALQAELEKAVV 879
            LE +  QH                         +E+  R+RR+ E    AL+A  EKA  
Sbjct: 1907 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1966

Query: 880  RGKELGARL-------EHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQA--- 929
               EL   L       E   R  EQA LE     +    + +R +  E+R++  L A   
Sbjct: 1967 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2026

Query: 930  AATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAM 989
            AA  ++ AL E++    ++EE   +LR+       ++    Q  E    RL   E+++A 
Sbjct: 2027 AARQRKAALEEVERLKAKVEEAR-RLRERAEQESARQLQLAQ--EAAQKRLQAEEKAHAF 2083

Query: 990  LVAEK-AALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHR 1048
             V +K   LQ  LQ  +  L  L+G A+     ++ A+E  +R+QAE+   + + Q    
Sbjct: 2084 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE--ARVQAEREAAQSRRQ---- 2137

Query: 1049 KLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRA 1108
                  EE    +QS EE     QA  R     A  + R+EAE E    R +  +A +R 
Sbjct: 2138 -----VEEAERLKQSAEE-----QAQARAQAQAAAEKLRKEAEQEAAR-RAQAEQAALRQ 2186

Query: 1109 LELAHRELQGRHEQLQAQRASVEAQ-EVALLAERERLMQDGHRQRGLEEELRRLQSEHDR 1167
             + A  E++ +H++   Q    +AQ E  L   R +L +  H++  L+EEL+RL++E   
Sbjct: 2187 KQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2245

Query: 1168 AQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQS--------QQLRESNQQLDL 1219
            A    +++  E   ++ +  EL    AR+E E   L ++         Q+  E  +Q+  
Sbjct: 2246 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2305

Query: 1220 SACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERS--LESRDHLHREQREY 1277
             A RL+   +   +LR   EE+  Q  A  + + +E  + ++ +  L++   L ++Q+E 
Sbjct: 2306 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2365

Query: 1278 L-DQLNALRREKQKLVEKIMDQ 1298
              +Q   L+ +K+++ +++ ++
Sbjct: 2366 AQEQARRLQEDKEQMAQQLAEE 2387



 Score =  140 bits (353), Expect = 9e-33
 Identities = 259/1088 (23%), Positives = 436/1088 (40%), Gaps = 161/1088 (14%)

Query: 217  ARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEE 276
            A E+ +  + LAE  LE++       A  R  AE     L  +    + Q + L +EL  
Sbjct: 1706 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1765

Query: 277  KAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAE----------LYREEAEA----- 321
                   +  + Q LEAE+ ++R E + L     RAE            R EAEA     
Sbjct: 1766 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1825

Query: 322  LRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVL----EASKALLEEQL--- 374
            L E A RL  L EE +R R+ L   +A + + E ERVL+  L    EA++   E ++   
Sbjct: 1826 LAEEAARLRALAEEAKRQRQ-LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1884

Query: 375  --EAARERCARLHET---QRENLL---------LRTRLGEAHAELDSLRHQVDQLAEENV 420
              EA  ER  RL E    QR  L          +  RL +     DS   +   L E+ +
Sbjct: 1885 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1944

Query: 421  -------ELELELQRSLEPPPGSPGEAPL------AGAAPSLQD-EVREAEAGRLRTL-E 465
                   E  L L+ S E       E  L      + A  +L+  E  E EA R R L  
Sbjct: 1945 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 2004

Query: 466  RENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDG 525
             E R  R   + +Q     +    EA R+      LEE  +     + + + L ++A   
Sbjct: 2005 EEERRRREAEERVQKSLAAEE---EAARQRKA--ALEEVERLKAKVEEA-RRLRERAEQE 2058

Query: 526  GPQALDLAPPALDSVLEASAECPQ-APDSDPQEAESPLQAAAMDPQASDWSPQESGSPVE 584
              + L LA  A    L+A  +    A     QE +  LQ    +    D    E+ +   
Sbjct: 2059 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ---QEQSVLDQLRGEAEAARR 2115

Query: 585  TQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQE 644
              E  E+A  ++  ++  S         +++  + L    E +   + +    A  LR+E
Sbjct: 2116 AAEEAEEARVQAEREAAQS-------RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2168

Query: 645  GPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE- 703
              +     ++     L +++            AE  +H +  E T+R    QK Q + E 
Sbjct: 2169 AEQEAARRAQAEQAALRQKQ---------AADAEMEKHKKFAEQTLR----QKAQVEQEL 2215

Query: 704  GALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAE-------ALGDELEAQARKLE 756
              L +Q+ E       L   +   +A   E A+ R + E          +EL     ++E
Sbjct: 2216 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2275

Query: 757  AQN--------TEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESAS 808
            A+N            R  +E A+  +  AE        A E ARLR+  E      E  +
Sbjct: 2276 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLA 2329

Query: 809  QEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEE----AERER 864
            Q+R AL E +    +E+ Q  +E +RL+A++E  +++ ++ + + R+  E+    A++  
Sbjct: 2330 QQR-ALAEKML---KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2385

Query: 865  REKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLE 924
             E +  Q  LE    R  E+ A  E L  +L  A + R +   E+++Q  R Q  E   +
Sbjct: 2386 EETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2443

Query: 925  AELQAAATSKEEALME-LKTRALQLEEELFQLRQGPAGLGPKK------------RAEPQ 971
                  AT ++  L++ L+ +  Q + +  +LR+  A L  +K            ++E  
Sbjct: 2444 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2503

Query: 972  LVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSR 1031
                Q   L E +      ++EK +L  + + +E +   L+   Q+ + ++Q+ +E   R
Sbjct: 2504 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2563

Query: 1032 LQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAE 1091
             Q +        QE  R +  +EE  R   +++E  R +Q+ L +      + QRRQ+ E
Sbjct: 2564 QQQQME------QERQRLVASMEEARRRQHEAEEGVRRKQEELQQ-----LEQQRRQQEE 2612

Query: 1092 LEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRA----------------SVEAQ-E 1134
            L  L   ++ L+  ++ LE  HR      E++ A +                 + EA+ E
Sbjct: 2613 L--LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2670

Query: 1135 VALLAERERLMQDGHRQRGL--EEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGR 1192
             +    R ++     ++ G+   EEL+RL   H      LA     R  LQG R  + G 
Sbjct: 2671 HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE-LARREDVRHYLQG-RSSIAGL 2728

Query: 1193 LARLELER 1200
            L +   E+
Sbjct: 2729 LLKATNEK 2736



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 148/629 (23%), Positives = 255/629 (40%), Gaps = 60/629 (9%)

Query: 716  PGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRA 775
            P    A  +AEQ+  + EV  L +    L  E E +   L   +  A  L  EL +    
Sbjct: 1042 PARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE-KVLALPEPSPAAPTLRSEL-ELTLG 1099

Query: 776  EAEAHREAEAQAWEQARLREAV---EAAGQELESASQEREALVEALAAAGRERRQWEREG 832
            + E  R   A   E+ +    V       +E+  A +E+    +A+ A   E    +   
Sbjct: 1100 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1159

Query: 833  SRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQ 892
             +LRAQ+EA +     L  E R   E  ER ++       E+E+   R  +L   LE  Q
Sbjct: 1160 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQ 1216

Query: 893  RELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEEL 952
              L Q  + RQ  L +   Q + Y+     L A LQ  A  ++E +  +     Q   E 
Sbjct: 1217 AVLAQTDV-RQRELEQLGRQLRYYRESADPLGAWLQ-DARRRQEQIQAMPLADSQAVRE- 1273

Query: 953  FQLRQGPAGLGPKKRAEPQLVETQNVR---LIEVERSNAMLVAEKAALQGQLQHLEGQLG 1009
             QLRQ  A L   +R   ++ E Q      +  ++     LV  KA L+        +  
Sbjct: 1274 -QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS--PAKKP 1330

Query: 1010 SLQGRAQELLLQSQRAQEHSSRLQAEKS-VLEIQGQELHRKLEVLEEEVRAARQSQEETR 1068
             +Q  ++ ++ +    + H S L    S  ++   + L R    +EEE R A Q + E R
Sbjct: 1331 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR----MEEEERLAEQQRAEER 1386

Query: 1069 ---GQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQA 1125
                + +A L   + LA+   + +A+ E      ++L+  M+  E+  RE      Q Q 
Sbjct: 1387 ERLAEVEAALEKQRQLAEAHAQAKAQAER---EAKELQQRMQE-EVVRREEAAVDAQQQK 1442

Query: 1126 QRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGE 1185
            +    E Q++   +E E +     +    E    R++ E    ++ L    R+RG  +GE
Sbjct: 1443 RSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1501

Query: 1186 RGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQL 1245
               LR R    E ++ Q + ++++LR                       R  Q+E  R+ 
Sbjct: 1502 LQALRARAEEAEAQKRQAQEEAERLR-----------------------RQVQDESQRKR 1538

Query: 1246 LAEVQALSRENREL-----LERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYR 1300
             AEV+  SR   E       +R+L++ + L  +  E   +L     E+ + V+  ++  +
Sbjct: 1539 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1598

Query: 1301 VLEPVPLPRTKKGSWLADKVKRLMRPRRE 1329
                  L ++K+ S+ A+K  +L R  +E
Sbjct: 1599 RSAEAEL-QSKRASF-AEKTAQLERSLQE 1625



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 131/567 (23%), Positives = 217/567 (38%), Gaps = 69/567 (12%)

Query: 694  AW-QKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAE-ALGDELEAQ 751
            AW ++ Q + +GA     W   +P  S+ + +     L + + + R K E A  DE +  
Sbjct: 557  AWVEENQHRVDGA----EWGVDLP--SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS 610

Query: 752  ARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQER 811
                 A      RL  + A+   +     R  E+       L   V AA +EL   +++ 
Sbjct: 611  PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES-------LHSFVAAATKELMWLNEKE 663

Query: 812  EALVEALAAAGRERRQWEREG-SRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEAL 870
            E  V    +        ++E  S L  + E  E++++ L++ G + L E    R   E+ 
Sbjct: 664  EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 723

Query: 871  QAELEKAVVRGKELGARLEHLQRELEQAALERQEF--LREKESQHQRYQ-GLEQRLEAEL 927
            QA L+       +L   +E     L++ A   Q F  +RE E Q Q+ Q  L ++   + 
Sbjct: 724  QAALQTQWSWMLQLCCCIE---AHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 780

Query: 928  QAAATSKEEALMELKTRALQLEEE------LFQLRQGPAGLGPKKRAEPQ-----LVETQ 976
             A  T  E+ L + +    QL E       L +  +    L P+  A P      L+   
Sbjct: 781  SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC 840

Query: 977  NVRLIEV---ERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQ 1033
            + + +EV   +     LV        ++    G   ++      +   +Q AQE  +RL+
Sbjct: 841  DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE 900

Query: 1034 AEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELE 1093
            A+   L     +LH  ++ L                  Q+L RD     QL R       
Sbjct: 901  AQHQALVTLWHQLHVDMKSLL---------------AWQSLRRD----VQLIRSWS---- 937

Query: 1094 GLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRG 1153
              L   R LK   +   L   EL  +     +Q A     E  L+AERE      H Q+ 
Sbjct: 938  --LATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQ- 994

Query: 1154 LEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELER------AQLEMQS 1207
            L + L +   E  R Q  ++EL   R +L+        RL RL L++      AQ   + 
Sbjct: 995  LLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL-RLPLDKEPARECAQRIAEQ 1053

Query: 1208 QQLRESNQQLDLSACRLTTQCELLTQL 1234
            Q+ +   + L     RL+ + E +  L
Sbjct: 1054 QKAQAEVEGLGKGVARLSAEAEKVLAL 1080


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  160 bits (405), Expect = 8e-39
 Identities = 275/1175 (23%), Positives = 490/1175 (41%), Gaps = 134/1175 (11%)

Query: 215  KLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQEL 274
            +L RE+ L  +R  +L  E++   LR E   R   E   H    Q    + + +RL++E 
Sbjct: 400  QLRREQQL--RREQQLRREQQ---LRREQQLRREQEEERHE---QKHEQERREQRLKREQ 451

Query: 275  EEKAELLLDSQAEVQGLEAEIRRLR----------------QEAQALSGQAKRAELYREE 318
            EE+ + L   + E +  E E R+ +                +E +    Q +R +  R E
Sbjct: 452  EERRDWL-KREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE 510

Query: 319  AEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAAR 378
             E  RE+  RL R QEE  R ++RL++ +  + + EE R      E  K L +E+ E   
Sbjct: 511  QEERREQ--RLKR-QEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERRE--- 564

Query: 379  ERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPG 438
            +R  R  E +R+ LL R        E +  + ++ +  EE +E  L+ +           
Sbjct: 565  QRLKREQEERRDQLLKR--------EEERRQQRLKREQEERLEQRLKREEVERLEQEERR 616

Query: 439  EAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVL 498
            E  L    P         E  R + L+ E +E R   Q+ + Q   +   L+   E+  L
Sbjct: 617  EQRLKREEPE--------EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL 668

Query: 499  PVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPD-SDPQE 557
               E+  +     +   Q L ++ ++   + +    P     LE+ A+  Q+   S P++
Sbjct: 669  ---EQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRK 725

Query: 558  AESPLQAAAMDPQAS------DWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQG-- 609
             E   +    + +         W  +E       Q+  E+  R  + Q  A     +G  
Sbjct: 726  QEGQRRRQEQEEKRRRRESELQWQEEERA---HRQQQEEEQRRDFTWQWQAEEKSERGRQ 782

Query: 610  -----PGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQE 664
                 P  + Q  + L    E R+  +   +PE     Q   + +    E   ++ EEQ 
Sbjct: 783  RLSARPPLREQRERQL--RAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL 840

Query: 665  GPNQGLDLATGQAEAREHDQ---RLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLA 721
               +       + +  + DQ   R +   RD  W+   ++        ++  P   E L 
Sbjct: 841  QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900

Query: 722  SGVAEQEALREEVAQLRR--KAEALGDELEAQARKLEAQNTEAARLSKELAQARRA---E 776
                EQ+ L+EE  +L+R  + +    E E Q R+ E    E  +L +E  + RR    E
Sbjct: 901  K---EQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERE 957

Query: 777  AEAHREAEAQAWEQA--------RLREAVEAAGQELESASQEREALVEALAAAGRERRQW 828
             +  ++ + Q  E+         R R+  E   +E E   QE E L+       R R++W
Sbjct: 958  RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLRE-EREKRRRQEW 1016

Query: 829  EREGSRLRAQSEAAEERMQVLESEG-RQHLEEAERERREKEALQAELEKAVVRGKELGAR 887
            ER+    R + E  +E  Q+L  E  ++ L+E ER+ RE+E LQ E E+ +   +E   R
Sbjct: 1017 ERQ---YRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRR 1073

Query: 888  --LEHLQRELEQAALERQEFLREKESQHQRYQGLEQ-RLEAELQAAATS-----KEEALM 939
              LE   R+ E+   E ++ LRE+  + +R +   Q R E ELQ          +E+   
Sbjct: 1074 QELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR 1133

Query: 940  ELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQG 999
            +   R  + EEE+ Q  +      P+KR   +L E Q     E+++    L+ E+     
Sbjct: 1134 QELERQYREEEEVQQEEEQLLREEPEKRRRQEL-ERQYREEEELQQEEEQLLREE----- 1187

Query: 1000 QLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRA 1059
              Q    Q    Q R +E L + +R Q +  R + ++S L+ Q  E  ++  V + +V  
Sbjct: 1188 --QEKRRQERERQYREEEELQRQKRKQRY--RDEDQRSDLKWQW-EPEKENAVRDNKVYC 1242

Query: 1060 ARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGR 1119
              +  E+ R  + + LRD ++   LQ     + E    + R  +   R       E   R
Sbjct: 1243 KGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERR-RWQQRDRHFPEEEQLER 1301

Query: 1120 HEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEH----DRAQMLLAEL 1175
             EQ +A+R   ++QE     E++ L ++   +R  +E  R+ + E     +R +  L   
Sbjct: 1302 EEQKEAKRRDRKSQE-----EKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356

Query: 1176 SRERGELQGE-RGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQL 1234
             R+R   + E R + +GR    E +R + + + ++  +  QQL    C+   Q     QL
Sbjct: 1357 ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL---RCQEREQ-----QL 1408

Query: 1235 RSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEK 1294
            R   ++ +R+   E Q LSR+ R+   R  E +      +R++L++   LR+E+ +   +
Sbjct: 1409 R---QDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE 1465

Query: 1295 IMDQYRVLEPVPLPRTKKGSWLADKVKRLMRPRRE 1329
                 +  E   L R ++     ++ ++L R  R+
Sbjct: 1466 EEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERD 1500



 Score =  150 bits (380), Expect = 7e-36
 Identities = 290/1199 (24%), Positives = 487/1199 (40%), Gaps = 129/1199 (10%)

Query: 215  KLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQEL 274
            +L RE++   +   E  L RE    R +   R         L  +    + Q  R  Q+L
Sbjct: 363  QLRREQE---EERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419

Query: 275  EEKAELLLDSQAE--VQGLEAEIR--RLRQEAQALSGQAKRAE-------------LYRE 317
              + +L  + + E   Q  E E R  RL++E +      KR E             L R+
Sbjct: 420  RREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRD 479

Query: 318  EAEALRERAGRLP----RLQEELRRCRERLQAAEAYKSQL---EEERVLSGVLEASKALL 370
            + E  RER  +L     R Q+E R  + R +  E  + +L   EEE  L   L + + L 
Sbjct: 480  QEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR 539

Query: 371  EEQLE-----AARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELE 425
             EQ E       RE   RL + +RE  L R    E     D L  + ++  ++ ++ E E
Sbjct: 540  REQEERREQLLKREEEKRLEQERREQRLKR----EQEERRDQLLKREEERRQQRLKREQE 595

Query: 426  --LQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPG 483
              L++ L+       E          ++E  E    R + L+ E +E R   Q+ + Q  
Sbjct: 596  ERLEQRLKREEVERLEQEERREQRLKREEPEEER--RQQLLKSEEQEERRQQQLRREQQE 653

Query: 484  GQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEA 543
             +   L+   E+     LE+  +     +   Q L ++ ++   + +    P     LE+
Sbjct: 654  RREQRLKREEEE---ERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710

Query: 544  SAECPQAP-DSDPQEAESPLQAAAMDPQAS------DWSPQESGSPVETQESPEKAGRRS 596
             A+  Q+   S P++ E   +    + +         W  +E       Q+  E+  R  
Sbjct: 711  EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER---AHRQQQEEEQRRDF 767

Query: 597  SLQSPASVAPPQG-------PGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHK 649
            + Q  A     +G       P  + Q  + L    E R+  +   +PE     Q   + +
Sbjct: 768  TWQWQAEEKSERGRQRLSARPPLREQRERQL--RAEERQQREQRFLPEEEEKEQRRRQRR 825

Query: 650  PGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQ---RLEGTVRDPAWQKPQQKSEGAL 706
                E   ++ EEQ    +       + +  + DQ   R +   RD  W+   ++     
Sbjct: 826  EREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRR 885

Query: 707  EVQVWEGPIPGESLASGVAEQEALREEVAQLRR--KAEALGDELEAQARKLEAQNTEAAR 764
               ++  P   E L     EQ+ L+EE  +L+R  + +    E E Q R+ E    E  +
Sbjct: 886  RHTLYAKPALQEQLRK---EQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQ 942

Query: 765  LSKELAQARR---AEAEAHREAEAQAWE--------QARLREAVEAAGQELESASQEREA 813
            L +E  + RR    E +  ++ + Q  E        + R R+  E   +E E   QE E 
Sbjct: 943  LLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQ 1002

Query: 814  LVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVL-ESEGRQHLEEAERERREKEALQA 872
            L+       R R++WER+    R + E  +E  Q+L E   ++ L+E ER+ RE+E LQ 
Sbjct: 1003 LLRE-EREKRRRQEWERQ---YRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ 1058

Query: 873  ELEKAVVRGKELGAR--LEHLQRELEQAALERQEFLREKESQHQRYQGLEQ-RLEAEL-- 927
            E E+ +   +E   R  LE   R+ E+   E ++ LRE+  + +R +   Q R E EL  
Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQ 1118

Query: 928  ---QAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVE 984
               Q     +E+   +   R  + EEE+ Q  +      P+KR   +L E Q     E++
Sbjct: 1119 EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQEL-ERQYREEEELQ 1177

Query: 985  RSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQ 1044
            +    L+ E+       Q    Q    Q R +E L + +R Q +  R + ++S L+ Q  
Sbjct: 1178 QEEEQLLREE-------QEKRRQERERQYREEEELQRQKRKQRY--RDEDQRSDLKWQ-W 1227

Query: 1045 ELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQ----RRQEAELEGLLVRHR 1100
            E  ++  V + +V    +  E+ R  + + LRD ++   LQ     +QE + E       
Sbjct: 1228 EPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDRE-----QE 1282

Query: 1101 DLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALL----AERERLMQDGHRQRGLEE 1156
              +   R       E   R EQ +A+R   ++QE   L     E +R  Q+  R+   EE
Sbjct: 1283 RRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEE 1342

Query: 1157 ELRRLQSEHDRAQMLLAELSRERGELQGERG----ELRGRLARLELERAQLEMQSQQLRE 1212
            +L + + E    +       RE      E+G    E   RL R E ER  L+ + QQLR 
Sbjct: 1343 QLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLK-EEQQLRC 1401

Query: 1213 SNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRE--LLERSLESRDHL 1270
              ++  L   R     E   QL  +++E +R+   E Q + R+ RE   LE   + R   
Sbjct: 1402 QEREQQLRQDRDRKFREEEQQL--SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQER 1459

Query: 1271 HREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRTKKGSWLADKVKRLMRPRRE 1329
            HR+ RE    L    RE+Q+L  +  D+  + E   L R ++     ++  R   P R+
Sbjct: 1460 HRKFREEEQLLQ--EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERK 1516



 Score =  149 bits (377), Expect = 1e-35
 Identities = 266/1092 (24%), Positives = 446/1092 (40%), Gaps = 130/1092 (11%)

Query: 264  KAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALR 323
            K Q RR RQ+   + E     + E +  E  +R+  ++ Q    Q +R EL  EE +  +
Sbjct: 226  KQQQRRERQDRVFQEE----EEKEWRKRETVLRKEEEKLQEEEPQRQR-ELQEEEEQLRK 280

Query: 324  ERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCAR 383
                 L R ++E  + ++RL+  +  + + EEER         +    EQ E  RE+  R
Sbjct: 281  LERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLR 340

Query: 384  LHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLA 443
              + +R    LR    E   E    R Q ++  E+ +  E +L+R               
Sbjct: 341  REQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE-------------- 386

Query: 444  GAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEE 503
                  Q   RE +  R + L RE ++LR   Q+ + Q   +   L   +E+        
Sbjct: 387  ------QQLRREQQLRREQQLRRE-QQLRREQQLRREQQLRREQQLRREQEE-------- 431

Query: 504  APQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQ 563
                    +   Q   Q+ R+   Q L          L+   E  +    + +  +  L+
Sbjct: 432  --------ERHEQKHEQERRE---QRLKREQEERRDWLKREEETER---HEQERRKQQLK 477

Query: 564  AAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGE 623
                + +   W   E     E QE  E+  RR   +        Q    ++Q  Q L  E
Sbjct: 478  RDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ--QRLRSE 535

Query: 624  TEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHD 683
             +               LR+E  E +    +    +  EQE   Q L     + E  E  
Sbjct: 536  QQ---------------LRREQEERREQLLKREEEKRLEQERREQRL-----KREQEERR 575

Query: 684  QRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEA 743
             +L     +   Q+ +++ E  LE ++    +  E L      ++ L+ E  +  R+ + 
Sbjct: 576  DQLLKREEERRQQRLKREQEERLEQRLKREEV--ERLEQEERREQRLKREEPEEERRQQL 633

Query: 744  LGDELEAQAR----KLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEA 799
            L  E + + R    + E Q     RL +E  +  R E    RE E +  EQ    E  E 
Sbjct: 634  LKSEEQEERRQQQLRREQQERREQRLKRE-EEEERLEQRLKREHEEERREQELAEEEQEQ 692

Query: 800  AGQELESASQEREALVEALAAAGRER---RQWEREGSRLRAQSEAAEERMQ---VLESEG 853
            A + ++S   + +  +E+ A A + +   R  ++EG R R + E    R +     + E 
Sbjct: 693  ARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEE 752

Query: 854  RQHLEEAERERREKEALQAELEKAVVRGKE-LGARLE-HLQRELEQAALERQE----FLR 907
            R H ++ E E+R     Q + E+   RG++ L AR     QRE +  A ERQ+    FL 
Sbjct: 753  RAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLP 812

Query: 908  EKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKR 967
            E+E + QR +   +R E ELQ     +EE  ++ + RA QL+EE   L++       ++R
Sbjct: 813  EEEEKEQRRRQRRER-EKELQFL---EEEEQLQRRERAQQLQEEEDGLQEDQ----ERRR 864

Query: 968  AEPQLVETQNVRLIEVERSNAM-LVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQ 1026
            ++ Q  + +    +E ER      +  K ALQ QL+  +  L   +   Q    + +R Q
Sbjct: 865  SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ 924

Query: 1027 EHSSRLQAEKSVLEIQGQELHRKLEV--LEEEVRAARQSQEETRGQQQALLRDHKALAQL 1084
            E   + + E+ + + + Q L  + E    +E  R  R+ ++  + ++Q L  + +   + 
Sbjct: 925  EQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQ 984

Query: 1085 QR----RQEAEL---EGLLVRHRDLKANMRALELAHR---ELQGRHEQ-LQAQRASVEAQ 1133
            +R    R+E EL   E  L+R    K   +  E  +R   ELQ   EQ L+ +R     Q
Sbjct: 985  EREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQ 1044

Query: 1134 E-VALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGR 1192
            E      E E L Q+  +  G E E RR Q E +R      EL +E  +L  E  E R R
Sbjct: 1045 ERERQYREEEELQQEEEQLLGEERETRRRQ-ELERQYRKEEELQQEEEQLLREEPEKRRR 1103

Query: 1193 LARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQE--EENRQLLAEVQ 1250
                  ER +   + ++L++  +QL         + EL  Q R  +E  +E  QLL E  
Sbjct: 1104 -----QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEP 1158

Query: 1251 ALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRT 1310
               +  R+ LER     + L +E+ +       LR E++K  ++   QYR  E   L R 
Sbjct: 1159 --EKRRRQELERQYREEEELQQEEEQ------LLREEQEKRRQERERQYR--EEEELQRQ 1208

Query: 1311 KKGSWLADKVKR 1322
            K+     D+ +R
Sbjct: 1209 KRKQRYRDEDQR 1220



 Score =  144 bits (362), Expect = 8e-34
 Identities = 278/1193 (23%), Positives = 472/1193 (39%), Gaps = 129/1193 (10%)

Query: 203  EMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEA--PSRAPAEGPSHHLALQL 260
            ++L R       +L RE++   +RL + L   E   L  E     R   E P      QL
Sbjct: 577  QLLKREEERRQQRLKREQE---ERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQL 633

Query: 261  ANAKAQLRR----LRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYR 316
              ++ Q  R    LR+E +E+ E  L  + E + LE  ++R  +E      + +  EL  
Sbjct: 634  LKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEE------ERREQELAE 687

Query: 317  EEAEALRERA-GRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLE 375
            EE E  RER   R+P+ Q +L    +  Q+    + + +E +      E  +   E +L+
Sbjct: 688  EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQ 747

Query: 376  AARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPG 435
               E   R H  Q+E    R    +  AE  S R +  Q       L  + +R L     
Sbjct: 748  WQEEE--RAHRQQQEEEQRRDFTWQWQAEEKSERGR--QRLSARPPLREQRERQLRAEER 803

Query: 436  SPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPRED 495
               E            E  E E  R +  ERE +EL+ L +  Q Q   +   L+   ED
Sbjct: 804  QQREQRFL-------PEEEEKEQRRRQRRERE-KELQFLEEEEQLQRRERAQQLQE-EED 854

Query: 496  PVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDP 555
             +    E         D   +  +++ R      L  A PAL   L    +  Q  + + 
Sbjct: 855  GLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL-YAKPALQEQLRKEQQLLQEEEEEL 913

Query: 556  QEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQ 615
            Q  E   +      Q   +  +E     E Q   E+  +R   +        +    K +
Sbjct: 914  QREER--EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEE 971

Query: 616  APQLLGGETEGREAPQGEL-VPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLAT 674
              QLLG E E R   + E    E   L+QE  E +    E    + +E E   +  D   
Sbjct: 972  --QLLGEEPEKRRRQEREKKYREEEELQQE--EEQLLREEREKRRRQEWERQYRKKDELQ 1027

Query: 675  GQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEV 734
             + E    ++R +  +++   ++ Q + E  L+                  E+E L  E 
Sbjct: 1028 QEEEQLLREEREKRRLQE---RERQYREEEELQ-----------------QEEEQLLGEE 1067

Query: 735  AQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRA---EAEAHREAEAQAWEQA 791
             + RR+      ELE Q RK E    E  +L +E  + RR    E +   E E Q  E+ 
Sbjct: 1068 RETRRR-----QELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQ 1122

Query: 792  RLREAVEAAG-QELESASQEREALV---EALAAAGRERRQWEREGSRLRAQSEAAEERMQ 847
             LRE  E    QELE   +E E +    E L     E+R+ +    + R + E  +E  Q
Sbjct: 1123 LLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQ 1182

Query: 848  VLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLE-HLQRELEQAALERQEFL 906
            +L  E  +  +E ER+ RE+E LQ +  K   R ++  + L+   + E E A  + + + 
Sbjct: 1183 LLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYC 1242

Query: 907  REKESQH------------QRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQ 954
            + +E++             Q  Q L Q L  E Q     +E    + + R    EE+L +
Sbjct: 1243 KGRENEQFRQLEDSQLRDRQSQQDL-QHLLGEQQERDREQERRRWQQRDRHFPEEEQLER 1301

Query: 955  LRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQL-QHLEGQLGSLQG 1013
              Q  A    K+R      E Q +R    E+        K   + QL Q  E Q    Q 
Sbjct: 1302 EEQKEA----KRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQE 1357

Query: 1014 RAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQA 1073
            R ++   +  R QE   +   E+    ++ QE  RK    E+++R   + Q+  + + + 
Sbjct: 1358 RDRKFREEELRHQEQGRKFLEEEQ--RLRRQERERKFLKEEQQLRCQEREQQLRQDRDRK 1415

Query: 1074 LLRDHKALAQLQRRQEAELEGLLVRHRD-----LKANMRALELAHRELQGRHEQLQ---A 1125
               + + L++ +R ++   E   VR ++     L+   +  +  HR+ +   + LQ    
Sbjct: 1416 FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREE 1475

Query: 1126 QRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHD--RAQMLLAELSRERGELQ 1183
            Q+   + ++   L E ++L +    ++  E+ELR  + E      +  L    R+R  LQ
Sbjct: 1476 QQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQ 1535

Query: 1184 GE---RGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEE 1240
             E   R + RG+  R + +R   E   +QLR+  ++  LS      +  L  Q    QE+
Sbjct: 1536 EEQQLRRQERGQQRRQDRDRKFRE--EEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593

Query: 1241 ENR---------------QLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALR 1285
            E +               QL  E     RE+ +LL+   E + H     R++L++   LR
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653

Query: 1286 REKQKLV------EKIMDQYRVL---EPVPLPRTKKGSWLADKVKRLMRPRRE 1329
            R++++         K  ++ ++L   E   L R ++     ++ ++L R  RE
Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERE 1706



 Score =  129 bits (325), Expect = 2e-29
 Identities = 175/707 (24%), Positives = 299/707 (42%), Gaps = 67/707 (9%)

Query: 654  EPSSVQLEEQEGPN-------QGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGAL 706
            EP   QLEE+ G         Q  +LA G+ E  E  +RLE        Q+ +Q+ +  L
Sbjct: 123  EPRDRQLEEEPGQRRRQKRQEQERELAEGE-EQSEKQERLE--------QRDRQRRDEEL 173

Query: 707  --EVQVWEGPIPGESLASGVAEQEALREEVAQLR----RKAEALGDELEAQARKLEAQNT 760
              + Q W+             E+E  R E  QL+     + E   DE + + R+L     
Sbjct: 174  WRQRQEWQ-------------EREERRAEEEQLQSCKGHETEEFPDEEQLRRREL----L 216

Query: 761  EAARLSKELAQARRAEAE--AHREAEAQAWEQAR--LREAVEAAGQELESASQEREALVE 816
            E  R  +E  Q +R E +    +E E + W +    LR+  E   +E     +E +   E
Sbjct: 217  ELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEE 276

Query: 817  ALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEK 876
             L    R+  + ER+    + Q    E++++  + E R+  +E  RE++E+   Q E  +
Sbjct: 277  QLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERRE 336

Query: 877  AVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGL--EQRLEAELQAAATSK 934
              +R ++   R + L+RE E+   E+Q  LR ++ + +R Q L  EQ+L  E Q     +
Sbjct: 337  QQLRREQEERREQQLRREQEEERREQQ--LRREQEEERREQQLRREQQLRREQQLRREQQ 394

Query: 935  EEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEK 994
                 +L+ R  QL  E  QLR+    L  +++   +  E ++ +  E ER    L  E+
Sbjct: 395  LRREQQLR-REQQLRREQ-QLRR-EQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ 451

Query: 995  AALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLE 1054
               +  L+  E      Q R ++ L + Q  +     L+ E+     Q +   ++L   +
Sbjct: 452  EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ 511

Query: 1055 EEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHR 1114
            EE R  R  ++E   + Q  LR  +   QL+R QE   E LL R  +     + LE   R
Sbjct: 512  EERREQRLKRQEEEERLQQRLRSEQ---QLRREQEERREQLLKREEE-----KRLEQERR 563

Query: 1115 ELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAE 1174
            E + + EQ + +   ++ +E       +R  ++   QR   EE+ RL+ E  R Q L  E
Sbjct: 564  EQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKRE 623

Query: 1175 LSRERGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQL 1234
               E    Q  + E +    + +L R Q E + Q+L+   ++  L   RL  + E   + 
Sbjct: 624  EPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQ-RLKREHEEERRE 682

Query: 1235 RSAQEEENRQLLAEVQALSRENRELLERSLE-------SRDHLHREQREYLDQLNALRRE 1287
            +   EEE  Q    +++   + +  LE   +       SR      QR   +Q    RR 
Sbjct: 683  QELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742

Query: 1288 KQKLVEKIMDQ-YRVLEPVPLPRTKKGSWLADKVKRLMRPRREGGPP 1333
            + +L  +  ++ +R  +     R     W A++     R R    PP
Sbjct: 743  ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPP 789



 Score =  129 bits (325), Expect = 2e-29
 Identities = 276/1150 (24%), Positives = 452/1150 (39%), Gaps = 149/1150 (12%)

Query: 224  AQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLD 283
            ++R  + L  R PL  + E   RA          L     K Q RR R+E E++ + L +
Sbjct: 777  SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFL-E 835

Query: 284  SQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERL 343
             + ++Q  E   ++L++E   L    +R    R   E  R++  R  +L+EE +R R  L
Sbjct: 836  EEEQLQRRE-RAQQLQEEEDGLQEDQER----RRSQEQRRDQKWRW-QLEEERKRRRHTL 889

Query: 344  QAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHA 403
             A  A + QL +E+ L         L EE+ E  RE   +    ++E           + 
Sbjct: 890  YAKPALQEQLRKEQQL---------LQEEEEELQREEREKRRRQEQER---------QYR 931

Query: 404  ELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRT 463
            E + L+ + +QL  E    E E +R  E       +  L      L  E  E E  R + 
Sbjct: 932  EEEQLQQEEEQLLRE----EREKRRRQERERQYRKDKKLQQKEEQLLGE--EPEKRRRQE 985

Query: 464  LERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKAR 523
             E++ RE   L Q        +  LL   RE       E   +         + L+++ R
Sbjct: 986  REKKYREEEELQQE-------EEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREER 1038

Query: 524  DGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPV 583
            +             +       E  Q  +    E     +   ++ Q       +     
Sbjct: 1039 E------KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQ 1092

Query: 584  ETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQ 643
              +E PEK  R+   +        Q      +  QLL  E E R   + E        RQ
Sbjct: 1093 LLREEPEKRRRQERERQCREEEELQQ-----EEEQLLREEREKRRRQELE--------RQ 1139

Query: 644  EGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKS- 702
               E +    E   ++ E ++   Q  +L     E  E  Q  E  +R+   ++ Q++  
Sbjct: 1140 YREEEEVQQEEEQLLREEPEKRRRQ--ELERQYREEEELQQEEEQLLREEQEKRRQERER 1197

Query: 703  ----EGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQ 758
                E  L+ Q  +     E   S +  Q    +E A    K    G E E Q R+LE  
Sbjct: 1198 QYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENE-QFRQLEDS 1256

Query: 759  NTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEAL 818
                 +  ++L      + E  RE E + W+Q   R+      ++LE   Q+     +  
Sbjct: 1257 QLRDRQSQQDLQHLLGEQQERDREQERRRWQQ---RDRHFPEEEQLEREEQKEAKRRDRK 1313

Query: 819  AAAGRERRQWEREGSRLRAQSEAA-EERMQVLESEGRQHLEEAERER--REKEALQAELE 875
            +   ++  + ERE  R R +++    E  Q+L+    Q L   ER+R  RE+E    E  
Sbjct: 1314 SQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQG 1373

Query: 876  KAVVRGKELGARLEHLQRELEQAALERQEFLREKESQ-----HQRYQGLEQRLEAELQAA 930
            +  +  ++   RL   +RE +    E+Q   +E+E Q      ++++  EQ+L  + +  
Sbjct: 1374 RKFLEEEQ---RLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR 1430

Query: 931  ATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLV-ETQNVRLIEVERSNAM 989
               +EE  +  + R  +  EE  QLRQ       K R E QL+ E +  +L   ER    
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQERHR---KFREEEQLLQEREEQQLHRQERDRKF 1487

Query: 990  LVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRK 1049
            L  E        Q L  Q    + R QEL     R+QE   +   E+  L  Q     R+
Sbjct: 1488 LEEE--------QQLRRQERDRKFREQEL-----RSQEPERKFLEEEQQLHRQ----QRQ 1530

Query: 1050 LEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRAL 1109
             + L+EE +  RQ     RGQQ+   RD K   + Q RQE E + L  + RD K  +   
Sbjct: 1531 RKFLQEEQQLRRQE----RGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQ 1586

Query: 1110 ELAHRELQGR-------------HEQLQAQRASVEAQEVALLAERERLMQDGHRQ----R 1152
            ++  +E + +              +QL+ +R     ++  LL ERE   Q  HRQ    +
Sbjct: 1587 KVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE--QQLHRQERDRK 1644

Query: 1153 GLEEE--LRRLQSE----HDRAQMLLAELSR-ERGELQGERGELRGRLARLELERAQLEM 1205
             LEEE  LRR + E    HDR +    E    + GE Q  R + R R  R E ++ + + 
Sbjct: 1645 FLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQE 1704

Query: 1206 QSQQLRESNQQL----------DLSACRLTTQCELLTQ---LRSAQEEENRQLLAEVQAL 1252
            + ++  +  QQL          +    R  T+ E L +    R   EEE  +   E Q L
Sbjct: 1705 RERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQL 1764

Query: 1253 SRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPV-PLPRTK 1311
             R+ R   +R     + L +E+ E   QL +   +++   E+ + Q R  + + P  R  
Sbjct: 1765 RRQER---DRKFREEEQLRQEREE--QQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819

Query: 1312 KGSWLADKVK 1321
            K  W  ++++
Sbjct: 1820 KYRWEEEQLQ 1829



 Score =  127 bits (318), Expect = 1e-28
 Identities = 263/1101 (23%), Positives = 427/1101 (38%), Gaps = 146/1101 (13%)

Query: 215  KLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQEL 274
            +L +E+ L  +   EL  E      R E   +   E        QL   + + RR RQE 
Sbjct: 898  QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR-RQER 956

Query: 275  EE---KAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPR 331
            E    K + L   + ++ G E E RR RQE         R + YREE E  +E    L  
Sbjct: 957  ERQYRKDKKLQQKEEQLLGEEPEKRR-RQE---------REKKYREEEELQQEEEQLLRE 1006

Query: 332  LQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQREN 391
             +E+ RR     Q  +  + Q EEE++L    E  K  L+E+    RE      + + E 
Sbjct: 1007 EREKRRRQEWERQYRKKDELQQEEEQLLRE--EREKRRLQERERQYREE--EELQQEEEQ 1062

Query: 392  LLLRTRLGEAHAELDSLRHQVDQLAEENVEL---ELELQRSLEPPPGSPGEAPLAGAAPS 448
            LL   R      EL+    + ++L +E  +L   E E +R  E       E  L      
Sbjct: 1063 LLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQ 1122

Query: 449  LQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTP 508
            L  E RE    R + LER+ RE   + Q        +  LL    E      LE   +  
Sbjct: 1123 LLREEREKR--RRQELERQYREEEEVQQE-------EEQLLREEPEKRRRQELERQYREE 1173

Query: 509  VAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMD 568
                   + L+++ ++   Q  +                 Q  + +  + +   Q    +
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERER----------------QYREEEELQRQKRKQRYRDE 1217

Query: 569  PQASD----WSPQESGSPVETQ---ESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLG 621
             Q SD    W P++  +  + +   +  E    R    S       Q      Q  Q L 
Sbjct: 1218 DQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQ------QDLQHLL 1271

Query: 622  GETEGREAPQGELVPEAWGLRQEG-PEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAR 680
            GE + R+  Q       W  R    PE +    E             +   L   + E +
Sbjct: 1272 GEQQERDREQER---RRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK 1328

Query: 681  EHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRK 740
               Q  +   R+   Q  Q++ E  L  Q  +     E L      ++ L EE    R++
Sbjct: 1329 RRRQETDRKFREEE-QLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQE 1387

Query: 741  AEAL----GDELEAQARKLEAQNTEAARLSKELAQARRAEAEAH-REAEAQAWEQARLRE 795
             E        +L  Q R+ + +     +  +E  Q  R E +   RE E Q   Q R R+
Sbjct: 1388 RERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERK 1447

Query: 796  AVEAAGQ----------ELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEER 845
             +E   Q          E E   QERE   + L    R+R+  E E  +LR Q    + R
Sbjct: 1448 FLEEEQQLRQERHRKFREEEQLLQEREE--QQLHRQERDRKFLEEE-QQLRRQERDRKFR 1504

Query: 846  MQVLESEG--RQHLEEAE---RERREKEALQAELE-KAVVRGKELGARLEHLQRELEQAA 899
             Q L S+   R+ LEE +   R++R+++ LQ E + +   RG++     +   RE EQ  
Sbjct: 1505 EQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLR 1564

Query: 900  LERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGP 959
             ER+E    ++ + ++++  EQ++  + Q     ++E  +  +    QL +E  +     
Sbjct: 1565 QEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDR----- 1619

Query: 960  AGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELL 1019
                 K R + QL++ +  + +  +  +   + E+  L+ Q             R Q+L 
Sbjct: 1620 -----KFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ------------EREQQLR 1662

Query: 1020 LQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLR--- 1076
                R      +L  E    +++ QE  RK    EEE +  RQ +E    Q++  LR   
Sbjct: 1663 HDRDRKFREEEQLLQEGEEQQLRRQERDRKFR--EEEQQLRRQERERKFLQEEQQLRRQE 1720

Query: 1077 -DHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEV 1135
             + K   + Q RQE E E L  + R  K       L   +L+   E+ Q +R        
Sbjct: 1721 LERKFREEEQLRQETEQEQLRRQERYRKI------LEEEQLRPEREEQQLRRQ------- 1767

Query: 1136 ALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLAR 1195
                ER+R  ++  + R   EE +    E DR      +L +ER E Q  R + R    R
Sbjct: 1768 ----ERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ-LRPQQRDGKYR 1822

Query: 1196 LELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRE 1255
             E E+ QLE Q Q+LR+   +      +   + +  TQ +S +EE+  +L  E +   R+
Sbjct: 1823 WEEEQLQLEEQEQRLRQERDR------QYRAEEQFATQEKSRREEQ--ELWQEEEQKRRQ 1874

Query: 1256 NRELLERSLESRDHLHREQRE 1276
             RE   R     +H+ R+Q+E
Sbjct: 1875 ERERKLR----EEHIRRQQKE 1891



 Score =  125 bits (314), Expect = 3e-28
 Identities = 273/1114 (24%), Positives = 436/1114 (39%), Gaps = 161/1114 (14%)

Query: 271  RQELEEKAELLLDSQAEVQGLEAEIR-RLRQEAQALSGQAKRAELYREEAEALRERAGRL 329
            R   + K  LL D + E      E R R  +E      + KR E  RE AE   E++ + 
Sbjct: 100  RARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEG-EEQSEKQ 158

Query: 330  PRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQ- 388
             RL++  R+ R+     +  + Q  EER             EEQL++ +      HET+ 
Sbjct: 159  ERLEQRDRQRRDEELWRQRQEWQEREERRAE----------EEQLQSCKG-----HETEE 203

Query: 389  -------RENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAP 441
                   R   LL  R      +    R + D++ +E  E E   + ++        E  
Sbjct: 204  FPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVL----RKEEEK 259

Query: 442  LAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVL 501
            L    P  Q E++E E  +LR LER+        +  Q Q   +   L   +E+      
Sbjct: 260  LQEEEPQRQRELQEEEE-QLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318

Query: 502  EEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESP 561
            EE  +             Q+ R+   Q  +     L    E   E     + + +  E  
Sbjct: 319  EERREQ------------QERRE---QQEERREQQLRREQEERREQQLRREQEEERREQQ 363

Query: 562  LQAAAMDPQASDWSPQESGSPVETQESPEKAGRR-SSLQSPASVAPPQGPGTKIQ---AP 617
            L+    + +      +E     E Q   E+  RR   L+    +   Q    + Q     
Sbjct: 364  LRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 423

Query: 618  QLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLD------ 671
            QL   + E R   + E       L++E  E +         +  EQE   Q L       
Sbjct: 424  QLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEE 483

Query: 672  -----LATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAE 726
                 L   + E RE  +R E  +R    ++ +Q+ +   E +  +  +  E       E
Sbjct: 484  RRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR--RE 541

Query: 727  QEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQ 786
            QE  RE++ + R + + L  E   Q  K E +      L +E     R +    RE E +
Sbjct: 542  QEERREQLLK-REEEKRLEQERREQRLKREQEERRDQLLKRE---EERRQQRLKREQE-E 596

Query: 787  AWEQARLREAVEAAGQE------LESASQEREALVEALAAAGRERRQWEREGSRLRAQSE 840
              EQ   RE VE   QE      L+    E E   + L +  +E R   R+    R Q E
Sbjct: 597  RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER---RQQQLRREQQE 653

Query: 841  AAEERMQVLESEGR--QHLE-EAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQ 897
              E+R++  E E R  Q L+ E E ERRE+E  + E E+A  R K   +R+   Q +LE 
Sbjct: 654  RREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIK---SRIPKWQWQLES 710

Query: 898  AALERQEFL----REKESQHQRYQGLE--QRLEAELQ------AAATSKEEALMELKTRA 945
             A  RQ  +    R++E Q +R +  E  +R E+ELQ      A    +EE      T  
Sbjct: 711  EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQ 770

Query: 946  LQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLE 1005
             Q EE+  + RQ       +  A P L E +  +L   ER                    
Sbjct: 771  WQAEEKSERGRQ-------RLSARPPLREQRERQLRAEER-------------------- 803

Query: 1006 GQLGSLQGRAQELL-LQSQRAQEHSSRLQAEKSVLEIQGQE---LHRKLEVLEEEVRAAR 1061
                  Q R Q  L  + ++ Q    R + EK +  ++ +E      + + L+EE    +
Sbjct: 804  ------QQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQ 857

Query: 1062 QSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVR---HRDLKANMRALELAHRELQG 1118
            + QE  R Q+Q   RD K   QL+  ++     L  +      L+   + L+    ELQ 
Sbjct: 858  EDQERRRSQEQR--RDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQ- 914

Query: 1119 RHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRE 1178
            R E+ + +R   E Q      E E+L Q+  +    E E RR Q E +R      +L ++
Sbjct: 915  REEREKRRRQEQERQ----YREEEQLQQEEEQLLREEREKRRRQ-ERERQYRKDKKLQQK 969

Query: 1179 RGELQGERGELRGRLARLELERAQLEMQSQQ---LRESNQQLDLSACRLTTQCELLTQLR 1235
              +L GE  E R R  R +  R + E+Q ++   LRE  ++      R   + E   + +
Sbjct: 970  EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREK------RRRQEWERQYRKK 1023

Query: 1236 SAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKI 1295
               ++E  QLL E     RE R L ER  + R+    +Q E  +QL    RE ++  +++
Sbjct: 1024 DELQQEEEQLLRE----EREKRRLQERERQYREEEELQQEE--EQLLGEERETRRR-QEL 1076

Query: 1296 MDQYRVLEPVPLPRTKKGSWLADKVKRLMRPRRE 1329
              QYR  E +   + ++   L ++ ++  R  RE
Sbjct: 1077 ERQYRKEEEL---QQEEEQLLREEPEKRRRQERE 1107



 Score =  123 bits (309), Expect = 1e-27
 Identities = 275/1166 (23%), Positives = 457/1166 (39%), Gaps = 170/1166 (14%)

Query: 192  PDPGELAPAELEMLSRSLMGTLSKLARER--------DLGAQRLAELLLEREPLCLRPEA 243
            PD  +L   EL  L R       +  RER        +    R  E +L +E   L+ E 
Sbjct: 205  PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEE 264

Query: 244  PSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQ 303
            P R            +L   + QLR+L     E+ EL  + Q E Q  +  +RR +Q  +
Sbjct: 265  PQRQR----------ELQEEEEQLRKL-----ERQELRRERQEEEQQ-QQRLRREQQLRR 308

Query: 304  ALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVL 363
                + +  +  R E +  RE+  +  R +++LRR +E  +  +  + Q EE R      
Sbjct: 309  KQEEERREQQEERREQQERREQ--QEERREQQLRREQEERREQQLRREQEEERR------ 360

Query: 364  EASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAEL---DSLRHQVDQLAEENV 420
                   E+QL   +E   R  + +RE  L R +      +L     LR +     E+ +
Sbjct: 361  -------EQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 413

Query: 421  ELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQG 480
              E +L+R          E  L       + E +  +  R + L+RE  E R  L+  + 
Sbjct: 414  RREQQLRR----------EQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK--RE 461

Query: 481  QPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSV 540
            +   +H   E  ++       EE  +  +  +   +   Q+ R              +  
Sbjct: 462  EETERHE-QERRKQQLKRDQEEERRERWLKLEEEERREQQERR--------------EQQ 506

Query: 541  LEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPV---ETQESPEKAGRRSS 597
            L    E  +      QE E  LQ      Q      +E    +   E ++  E+  R   
Sbjct: 507  LRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQR 566

Query: 598  LQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSS 657
            L+             + +  QLL  E E R+        E    R +  E +    E   
Sbjct: 567  LKRE----------QEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERR 616

Query: 658  VQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPG 717
             Q  ++E P +  +      ++ E ++R +  +R    ++ +Q+ +   E +  E  +  
Sbjct: 617  EQRLKREEPEE--ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR 674

Query: 718  ESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEA 777
            E       EQE   EE  Q R + ++   + + Q      ++   AR SK  ++ R+ E 
Sbjct: 675  EH-EEERREQELAEEEQEQARERIKSRIPKWQWQ-----LESEADARQSKVYSRPRKQEG 728

Query: 778  EAHREAEAQAWEQARLREAVEAAGQELESA--SQEREALVEALAAAGRERRQWEREGSRL 835
            +  R+ +    E+ R R   E   QE E A   Q+ E          +   + ER   RL
Sbjct: 729  QRRRQEQ----EEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRL 784

Query: 836  RAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQREL 895
             A+    E+R + L +E        ER++RE+  L  E EK          R +  +RE 
Sbjct: 785  SARPPLREQRERQLRAE--------ERQQREQRFLPEEEEKE-------QRRRQRREREK 829

Query: 896  EQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQL 955
            E   LE +E L+ +E + Q+ Q  E  L+ + +   +  +E   + K R  QLEEE  + 
Sbjct: 830  ELQFLEEEEQLQRRE-RAQQLQEEEDGLQEDQERRRS--QEQRRDQKWR-WQLEEERKRR 885

Query: 956  RQ---GPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQ 1012
            R        L  + R E QL++ +   L   ER       EK   Q Q +    +   LQ
Sbjct: 886  RHTLYAKPALQEQLRKEQQLLQEEEEELQREER-------EKRRRQEQERQYREE-EQLQ 937

Query: 1013 GRAQELL---LQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAAR-QSQEETR 1068
               ++LL    + +R QE   + + +K + + + Q L  + E    + R  + + +EE +
Sbjct: 938  QEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQ 997

Query: 1069 GQQQALLRDHKALAQLQRRQEAEL-----------EGLLVRHRDLKANMRALELAHR--- 1114
             +++ LLR+ +   + +RRQE E            E  L+R    K  ++  E  +R   
Sbjct: 998  QEEEQLLREER---EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEE 1054

Query: 1115 ELQGRHEQLQA-QRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLA 1173
            ELQ   EQL   +R +   QE+     +E  +Q    Q   EE  +R + E +R      
Sbjct: 1055 ELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEE 1114

Query: 1174 ELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQ 1233
            EL +E  +L  E  E R    R ELER   E   +++++  +QL         + EL  Q
Sbjct: 1115 ELQQEEEQLLREEREKR---RRQELERQYRE--EEEVQQEEEQLLREEPEKRRRQELERQ 1169

Query: 1234 LRSAQE--EENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQ----------- 1280
             R  +E  +E  QLL E Q   R+ RE   R  E      R+QR Y D+           
Sbjct: 1170 YREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR-YRDEDQRSDLKWQWE 1228

Query: 1281 ---LNALRREKQKLVEKIMDQYRVLE 1303
                NA+R  K     +  +Q+R LE
Sbjct: 1229 PEKENAVRDNKVYCKGRENEQFRQLE 1254



 Score =  115 bits (288), Expect = 3e-25
 Identities = 138/495 (27%), Positives = 214/495 (43%), Gaps = 41/495 (8%)

Query: 824  ERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKE 883
            E ++   +G     Q    EE  +  E   RQ  EE  + RR+K   + E E+ +  G+E
Sbjct: 97   EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQK---RQEQERELAEGEE 153

Query: 884  LGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKT 943
               + E L++       +RQ    E   Q Q +Q  E+R  AE +   + K     E   
Sbjct: 154  QSEKQERLEQR------DRQRRDEELWRQRQEWQEREER-RAEEEQLQSCKGHETEEFPD 206

Query: 944  RALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAAL------ 997
                   EL +LR+       ++R E Q    Q     E  +   +L  E+  L      
Sbjct: 207  EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266

Query: 998  -QGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEE 1056
             Q +LQ  E QL  L+   QEL  + Q  ++   RL+ E+ +   Q +E   + E   E+
Sbjct: 267  RQRELQEEEEQLRKLE--RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ 324

Query: 1057 VRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHREL 1116
             +  R+ QEE R QQ    ++ +   QL+R QE E     +R R+ +   R  +L  RE 
Sbjct: 325  -QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLR-REQEEERREQQL-RREQ 381

Query: 1117 QGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGL--EEELRRLQSEHDRAQMLLAE 1174
            Q R EQ   +   +  ++     ++ R  Q   R++ L  E++LRR Q E    Q    E
Sbjct: 382  QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQK--HE 439

Query: 1175 LSRERGELQGERGELRGRLAR-LELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQ 1233
              R    L+ E+ E R  L R  E ER + E + QQL+   ++      R     +L  +
Sbjct: 440  QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEE-----RRERWLKLEEE 494

Query: 1234 LRSAQEEENRQLLAEVQALSRENR-------ELLERSLESRDHLHREQREYLDQLNALRR 1286
             R  Q+E   Q L   Q   RE R       E L++ L S   L REQ E  +QL  L+R
Sbjct: 495  ERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL--LKR 552

Query: 1287 EKQKLVEKIMDQYRV 1301
            E++K +E+   + R+
Sbjct: 553  EEEKRLEQERREQRL 567



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 156/717 (21%), Positives = 266/717 (37%), Gaps = 101/717 (14%)

Query: 254  HHLALQLANAKAQLRRLRQELE----EKAELLLDSQAEVQGLEA----EIRRLRQEAQAL 305
            H L  Q    + Q RR  Q+ +    E+ +L  + Q E +  +     E + LR+E +  
Sbjct: 1269 HLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK 1328

Query: 306  SGQAKRAELYREEAEALRERAGRLPRLQEELRRCRER-LQAAEAYKSQLEEERVLSGVLE 364
              + +    +REE + L+ER  +  R QE  R+ RE  L+  E  +  LEEE+ L     
Sbjct: 1329 RRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQER 1388

Query: 365  ASKALLEEQLEAARERCARLHET-------QRENLLLRTRLGEAHAELDSLRHQVDQ--L 415
              K L EEQ    +ER  +L +        + + L  + R  +   E   +R Q  +   
Sbjct: 1389 ERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKF 1448

Query: 416  AEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLL 475
             EE  +L  E  R                     +  ++E E  +L   ER+ + L    
Sbjct: 1449 LEEEQQLRQERHRKFREE----------------EQLLQEREEQQLHRQERDRKFLEEEQ 1492

Query: 476  QVLQGQPGGQHPLLEAPREDPVLPVLEEAPQT-----PVAFDHSPQGLVQKARDGGPQAL 530
            Q+ + +   +    E   ++P    LEE  Q         F    Q L ++ R G  +  
Sbjct: 1493 QLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQER-GQQRRQ 1551

Query: 531  DLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPE 590
            D      D       +  Q  +      +   +   ++ Q      QE     + Q+   
Sbjct: 1552 DR-----DRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRR 1606

Query: 591  KAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGE----LVPEAWGLRQEGP 646
            + G++   Q             K +  + L  E E ++  + E     + E   LR++  
Sbjct: 1607 QEGQQQLRQER---------DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQER 1657

Query: 647  EHKPGPSEPSSVQLEEQ---EGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE 703
            E +         + EEQ   EG  Q L       + RE +Q+L    R+  + + +Q+  
Sbjct: 1658 EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQ-- 1715

Query: 704  GALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAA 763
                       +  + L     E+E LR+E  Q         ++L  Q R  +    E  
Sbjct: 1716 -----------LRRQELERKFREEEQLRQETEQ---------EQLRRQERYRKILEEEQL 1755

Query: 764  RLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGR 823
            R  +E  Q RR E +     E Q  ++   RE  +   QE +   +E E L +       
Sbjct: 1756 RPEREEQQLRRQERDRKFREEEQLRQE---REEQQLRSQESDRKFREEEQLRQ------- 1805

Query: 824  ERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKE 883
                 ERE  +LR Q    + R    E E  Q  E+ +R R+E++      E+   + K 
Sbjct: 1806 -----EREEQQLRPQQRDGKYRW---EEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKS 1857

Query: 884  LGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALME 940
                 E  Q E ++   ER+  LRE+  + Q+ +    R   E+++        L+E
Sbjct: 1858 RREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 149/674 (22%), Positives = 246/674 (36%), Gaps = 68/674 (10%)

Query: 259  QLANAKAQLRRLRQELEEK--AELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYR 316
            QL   + + +R RQE + K   E  L  + E Q L  + R  +   + L  Q +  +   
Sbjct: 1319 QLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLE 1378

Query: 317  EEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQL--EEERVLSGVLEASKALLEEQL 374
            EE    R+   R    +E+  RC+ER Q     + +   EEE+ LS      K   EEQ 
Sbjct: 1379 EEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQ 1438

Query: 375  EAARERCARLHETQRENLLLRTRLGEAHAELDSLRH--QVDQLAEENVELELELQRSLEP 432
               +ER  +  E +++    R R      +L   R   Q+ +   +   LE E Q   + 
Sbjct: 1439 VRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE 1498

Query: 433  PPGSPGEAPLAGAAPS---LQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLL 489
                  E  L    P    L++E +     R R   +E ++LR   +  +GQ   Q    
Sbjct: 1499 RDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLR---RQERGQQRRQDRDR 1555

Query: 490  EAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQ 549
            +   E+ +    EE   +    D   +   QK R    +   +         E   +  Q
Sbjct: 1556 KFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQ 1615

Query: 550  APDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQG 609
              D   +E E  LQ                    E Q+   +   R  L+          
Sbjct: 1616 ERDRKFREDEQLLQER------------------EEQQLHRQERDRKFLE---------- 1647

Query: 610  PGTKIQAPQLLGGETEGR-EAPQGELVPEAWGLRQEGPEHKPGPSEPS-SVQLEEQEGPN 667
                 + PQL   E E +    +     E   L QEG E +    E     + EEQ+   
Sbjct: 1648 -----EEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRR 1702

Query: 668  QGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQ 727
            Q  +    Q E +   Q LE   R+    + + + E     + +   +  E L     EQ
Sbjct: 1703 QERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQ 1762

Query: 728  EALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQ- 786
            +  R+E  +  R+ E L  E E Q    + ++ E+ R  +E  Q R+   E     + + 
Sbjct: 1763 QLRRQERDRKFREEEQLRQEREEQ----QLRSQESDRKFREEEQLRQEREEQQLRPQQRD 1818

Query: 787  ---AWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAE 843
                WE+ +L+  +E   Q L      +    E  A   + RR+ E+E  +   Q    E
Sbjct: 1819 GKYRWEEEQLQ--LEEQEQRLRQERDRQYRAEEQFATQEKSRRE-EQELWQEEEQKRRQE 1875

Query: 844  ERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLE---HLQRELEQAAL 900
               ++ E   R+  +E +R R+  E    E       GK  G  LE   H    +   + 
Sbjct: 1876 RERKLREEHIRRQQKEEQRHRQVGEIKSQE-------GKGHGRLLEPGTHQFASVPVRSS 1928

Query: 901  ERQEFLREKESQHQ 914
               E+++E+ SQ++
Sbjct: 1929 PLYEYIQEQRSQYR 1942



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 73/292 (25%), Positives = 112/292 (38%), Gaps = 30/292 (10%)

Query: 219  ERDLGAQRLAELLLEREPLCLRPEAPSRAP--------------AEGPSHHLALQLANAK 264
            E+ L  Q      LE EP   R E   +                 EG    L  Q  + K
Sbjct: 1633 EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRK 1692

Query: 265  --AQLRRLRQELEEKAELLLDSQAEVQGLEAEIR---RLRQEAQALSGQAKRAELYREEA 319
               + ++LR++  E+  L  + Q   Q LE + R   +LRQE +    Q +R E YR+  
Sbjct: 1693 FREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETE--QEQLRRQERYRK-- 1748

Query: 320  EALRERAGRLPRLQEELRRC-RERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAAR 378
              L E   R  R +++LRR  R+R    E    Q  EE+ L       K   EEQL   R
Sbjct: 1749 -ILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQER 1807

Query: 379  ERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPG 438
            E   +L   QR+    + R  E   +L+    ++ Q  +     E E   + E       
Sbjct: 1808 EE-QQLRPQQRDG---KYRWEEEQLQLEEQEQRLRQERDRQYRAE-EQFATQEKSRREEQ 1862

Query: 439  EAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLE 490
            E          Q+  R+     +R  ++E +  R + ++   +  G   LLE
Sbjct: 1863 ELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  159 bits (403), Expect = 1e-38
 Identities = 272/1087 (25%), Positives = 442/1087 (40%), Gaps = 149/1087 (13%)

Query: 268  RRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAG 327
            R+L Q  EEK++     + +   LE+E+  L +   +L  + +RAEL R EA+  RE   
Sbjct: 1292 RQLSQNQEEKSKW----EGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGEREL-- 1345

Query: 328  RLPRLQEELRRCRERLQAAEAY-KSQLEEERVLSGVLEASKALLE---EQLEAARERCAR 383
             L   +E L    E LQAA    ++Q     +L   L  +++ L+   E++E+ RER   
Sbjct: 1346 -LQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQA 1404

Query: 384  LHE----------TQRENLLLRTR-LGEAHAELDSLRHQVDQLAEEN------------- 419
            L E            +ENL L T+ L E   E+++LR Q+ +L ++              
Sbjct: 1405 LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLD 1464

Query: 420  -------VELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELR 472
                   V+L+ E  + LE         P+A      +++    +  ++R LE++    R
Sbjct: 1465 LKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQE---REQKLTVQREQIRELEKDRETQR 1521

Query: 473  GLLQVLQGQPGGQHPLLEAPREDPVLP-------------VLEEAPQTPVAFDHSPQGLV 519
             +L+         H LLE  ++D ++              V  E     +  +H      
Sbjct: 1522 NVLE---------HQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQ 1572

Query: 520  QKA---RDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSP 576
            QK     +G  +   +A   L   LE  ++  QA  S   + ES     A + Q  D   
Sbjct: 1573 QKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEV 1632

Query: 577  QESGSPVE---------TQESPEKAGRRSSLQSPASVAPPQGPG-TKIQAPQLLGGETEG 626
            +     +E         TQ+   +       +    V   Q    TKI    L   +   
Sbjct: 1633 KSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSL 1692

Query: 627  REAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEA---REHD 683
            RE  +G  +     L QE  E   GPS+     LE  +     L L   + E    +EH 
Sbjct: 1693 RE--RGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMK-----LILRDKEKEVECQQEHI 1745

Query: 684  QRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEA 743
              L+  ++D   Q+ Q       E  +    +  +     V  Q+ L+E   Q   K ++
Sbjct: 1746 HELQ-ELKDQLEQQLQGLHRKVGETSL----LLSQREQEIVVLQQQLQEAREQGELKEQS 1800

Query: 744  LGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQ--AWEQARLREAVEAAG 801
            L  +L+   R L  ++ E   L +E  QA+  E     +A+A   A EQA +   ++   
Sbjct: 1801 LQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHM--TLKERH 1858

Query: 802  QELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAE 861
             EL+   ++   L E LA  GR  +  E     LRA+S   E+ +  L+   +Q  E+A+
Sbjct: 1859 GELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQ---QQCAEQAQ 1915

Query: 862  RERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQ 921
                E  ALQ    +A        A L+   +ELE    E Q    ++E+   R + L++
Sbjct: 1916 EHEVETRALQDSWLQA-------QAVLKERDQELEALRAESQSSRHQEEAARARAEALQE 1968

Query: 922  RLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLI 981
             L  +  AA   KE+ L+E    +  LE     L+   A L   +    QL E   ++  
Sbjct: 1969 AL-GKAHAALQGKEQHLLEQAELSRSLEASTATLQ---ASLDACQAHSRQLEEALRIQEG 2024

Query: 982  EVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQ-SQRAQEH----SSRLQAEK 1036
            E++  +     +   LQ  L   + +L   Q R Q L    +QR QE+       L  E+
Sbjct: 2025 EIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQER 2084

Query: 1037 SVLEIQG-----QELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKA---------LA 1082
               EI+G     +EL   L   E+E+   R++Q+  R   +AL   HK          L 
Sbjct: 2085 EEEEIRGLHQSVRELQLTLAQKEQEILELRETQQ--RNNLEALPHSHKTSPMEEQSLKLD 2142

Query: 1083 QLQRRQEAELEGLLVRHRDLKANMRALELAHRE-LQGRHEQLQAQRASVEA-QEVALLAE 1140
             L+ R + ELE L    R  +A     E+  RE  Q     L   +ASV + QEVA+  +
Sbjct: 2143 SLEPRLQRELERLQAALRQTEAR----EIEWREKAQDLALSLAQTKASVSSLQEVAMFLQ 2198

Query: 1141 RERLMQDGHRQRGLEE-ELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELE 1199
               L +D  +QR  +E EL R   E +R     A  + E G  +GE+G   G ++ +E E
Sbjct: 2199 ASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGS-RGEQGVQLGEVSGVEAE 2257

Query: 1200 RAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENREL 1259
             +   M+ Q  R+  + L  +  RL          RS  +  N QL + ++ + RE R+L
Sbjct: 2258 PSPDGMEKQSWRQRLEHLQQAVARLEID-------RSRLQRHNVQLRSTLEQVERERRKL 2310

Query: 1260 LERSLES 1266
               ++ +
Sbjct: 2311 KREAMRA 2317



 Score =  157 bits (398), Expect = 5e-38
 Identities = 300/1238 (24%), Positives = 503/1238 (40%), Gaps = 154/1238 (12%)

Query: 159  HIQG-LSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLA 217
            H++G L  + Q+E+ AA+    Q    +    S  +  +   A+L   +  L      LA
Sbjct: 553  HLEGELLRQEQTEVTAALARAEQ---SIAELSSSENTLKTEVADLRAAAVKLSALNEALA 609

Query: 218  RERDLGAQRLAELLLEREPLCLRPEAPSRAP-------AEGPSH---------HLALQLA 261
             ++    Q+L +L  E + +C R EA  +A        AE             HL  QL 
Sbjct: 610  LDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQ 669

Query: 262  NAK-------AQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAEL 314
             A+       A LR +++E EE  + L +S+ + +    ++ +L QEA+       RA  
Sbjct: 670  KAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAV- 728

Query: 315  YREEAEAL-RERAG---RLPRLQEELRRCRERLQ----AAEAYKSQLEEERVLSGVLEAS 366
              +E EAL RE+A    RL  ++ + +   E+LQ    A E  +S L E +  + V+E +
Sbjct: 729  --QEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVT 786

Query: 367  KALLEEQLEAARERCARLH-ETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENV----- 420
            K  LE Q++   +    +  E +   L L T   +A  E D+   Q+ Q  +E       
Sbjct: 787  KGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQ 846

Query: 421  -----ELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLL 475
                 E E+   R       S  +  LA A  SL+ E  E E  RL+  + E   ++   
Sbjct: 847  QKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEM-RLKEQQTEMEAIQAQR 905

Query: 476  QVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPP 535
            +  + Q       ++   E   + +LE   QT      + Q L +  +D   Q L     
Sbjct: 906  EEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK---- 961

Query: 536  ALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRR 595
                      E      +  QEA+  L+ AA   +    + QE  S +  Q+  +   + 
Sbjct: 962  --------EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSL-LQDKMDLQKQV 1012

Query: 596  SSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLR---QEGPEHKPGP 652
              L+S   VA         Q  Q    ET+     Q EL  E   L     E  +     
Sbjct: 1013 EDLKSQL-VAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVL 1071

Query: 653  SEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWE 712
             E  S++ +E     Q  D+   Q E +E   ++E           Q+  E   +    E
Sbjct: 1072 QEADSIRQQELSALRQ--DMQEAQGEQKELSAQME--------LLRQEVKEKEADFLAQE 1121

Query: 713  GPIPGESLASGVAEQE------ALREEVAQLRRKAEALGDELEAQARKLEAQN-----TE 761
              +  E  AS + EQ+      A   + AQL+ +  +   +LEA A + +  N      +
Sbjct: 1122 AQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQ 1181

Query: 762  AARLSKELAQARRAEAEAHREAEAQAWEQARL--REAVEAAGQELESASQEREAL-VEAL 818
             A L   L QA  +  E+  E          +   E  +   + L        AL  EA+
Sbjct: 1182 LASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAV 1241

Query: 819  AAAGRERRQ--WEREGSR--LRAQSEAAEERMQVLESEGRQ----------HLEEAERER 864
            A+A  +  Q  W+ + +R  LR Q +  EER+   E+E  Q           L + + E+
Sbjct: 1242 ASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEK 1301

Query: 865  REKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLE 924
             + E  Q  LE  ++   EL   +  LQ  L +A L+R E   E+E      + L  ++E
Sbjct: 1302 SKWEGKQNSLESELM---ELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVE 1358

Query: 925  --------AELQAAATSKEEALMELKTRALQLE-EELFQLRQGPAGL---GPKKRAEPQL 972
                    A  QA+A    E  +     AL+L+ EE+   R+    L   G  K A+ + 
Sbjct: 1359 HLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKA 1418

Query: 973  VETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLG-----------SLQGRAQELLLQ 1021
            ++ +N+ L+   ++ A    E   L+GQ+Q LE Q              L+ R QE+ LQ
Sbjct: 1419 LQ-ENLALLT--QTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQ 1475

Query: 1022 SQRAQEHSSRLQAEKSVLE---IQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDH 1078
             ++ QE    L+  +SVLE   +  QE  +KL V  E++R   + +E  R   +  L + 
Sbjct: 1476 QEQIQE----LEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531

Query: 1079 KALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALL 1138
            +   Q+   Q  +++       DLK  +  LE    EL+  H +++ Q+  ++  E    
Sbjct: 1532 EKKDQMIESQRGQVQ-------DLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRE 1584

Query: 1139 AERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLEL 1198
             +R  L    H    LEE  + LQ++  +   L +  +    ELQ    E++ +  ++E 
Sbjct: 1585 TQRVALT---HLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEE 1641

Query: 1199 ERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRE--- 1255
             + Q E  +Q L   +Q+L L   R+    +  T+     EE+  Q+   ++   RE   
Sbjct: 1642 LQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTT 1701

Query: 1256 NRELLERSLESRDHLHREQREYLDQLNALRREKQKLVE 1293
             R+L++   E      + QR  L+ +  + R+K+K VE
Sbjct: 1702 QRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE 1739



 Score =  144 bits (364), Expect = 5e-34
 Identities = 299/1258 (23%), Positives = 510/1258 (40%), Gaps = 200/1258 (15%)

Query: 197  LAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHL 256
            LA  E E L   LMG  +K +       + L+EL+  RE L               S HL
Sbjct: 516  LAVRERERLQEMLMGLEAKQS-------ESLSELITLREAL--------------ESSHL 554

Query: 257  ALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYR 316
              +L         LRQE  E    L  ++  +  L +    L+ E   L   A +     
Sbjct: 555  EGEL---------LRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALN 605

Query: 317  EEAEALRERAG---RLPRLQEELRRCRERLQAAEAYKSQLE----EERVLSGVLEASKAL 369
            E A AL ++ G   +L +L+EE +    R++AAE  ++ L+    E       L      
Sbjct: 606  E-ALAL-DKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTH 663

Query: 370  LEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRS 429
            LE QL+ A E  A L    R+   ++    E   +L   RHQ +    +  +L  E +R 
Sbjct: 664  LEAQLQKAEEAGAELQADLRD---IQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ 720

Query: 430  LEPPPGSPGEAPLAGAAPSLQDEVREAEA--GRLRTLERENRELRGLLQVLQGQPGG-QH 486
                     E  LA A    +  VRE  A   RL+ +ER+ ++L   LQ L       + 
Sbjct: 721  ---------EEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLES 771

Query: 487  PLLEAPREDPVLPV----LEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLE 542
             L EA +++ V+ V    LE   QT        QG V+  +                 LE
Sbjct: 772  SLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLK-----------------LE 814

Query: 543  ASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGR-RSSLQSP 601
               E  QA       A    QA      A +   Q++    E  +  EK  + RS  Q  
Sbjct: 815  LDTERSQAEQERDAAARQLAQAEQEGKTALE--QQKAAHEKEVNQLREKWEKERSWHQQE 872

Query: 602  ASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLE 661
             + A       K++    L  +    EA Q +        R+E  E     S    +QLE
Sbjct: 873  LAKALESLEREKMELEMRLKEQQTEMEAIQAQ--------REE--ERTQAESALCQMQLE 922

Query: 662  -EQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQK-PQQKSEGALEVQVWEGPIPGES 719
             E+E  +    L   Q E  +  Q+LE   +D   QK  +Q++ G L+ Q+ E     + 
Sbjct: 923  TEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKE 982

Query: 720  LASGVAEQ-EALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAE 778
             A    +   AL+EE + L +    L  ++E    +L AQ+     + +E+ +  R   E
Sbjct: 983  AARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQE 1042

Query: 779  AHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQ 838
             +R  +    E+A L  ++    Q L    +      + L+A  ++ ++ + E   L AQ
Sbjct: 1043 YNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQ 1102

Query: 839  SEAAEERMQVLESE----GRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRE 894
             E   + ++  E++      Q LEE E     ++ L+A L     +  +L  RL   + +
Sbjct: 1103 MELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQ 1162

Query: 895  LEQAALERQEFLREKESQHQR---YQGLEQRLEA------ELQAAATSKEEA-------- 937
            LE  A E+Q    + ++Q Q    Y  L+Q L +      EL     S            
Sbjct: 1163 LEALAAEQQPG-NQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQN 1221

Query: 938  -----------LMELKTRAL-----QLEEELFQLRQGPAGLGPK-KRAEPQLVETQ---- 976
                       L  L   A+     +L ++L++ +Q    L  + ++ E +L +T+    
Sbjct: 1222 GARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKS 1281

Query: 977  --NVRLIEVERSNAMLVAEKAALQGQLQHLEGQL-------GSLQGRAQELLLQSQRAQE 1027
              +  L +++R  +    EK+  +G+   LE +L        SLQ R +   LQ   AQ 
Sbjct: 1282 QVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQG 1341

Query: 1028 HSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQAL-LRDHKALAQLQR 1086
                LQA K  L  Q + L   +     +  AA   +E+ R  + AL L++ +  ++ +R
Sbjct: 1342 ERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERER 1401

Query: 1087 RQEAELEGLL--VRHRDLKANMRAL--ELAHRE-----LQGRHEQLQAQRASVEAQEVAL 1137
             Q  + +G L   + + L+ N+  L   LA RE     L+G+ ++L+ QR   +A    L
Sbjct: 1402 AQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELL 1461

Query: 1138 LAERERLMQDGHRQRGLEEELRRLQS--EH------DRAQML------LAELSRERGELQ 1183
              + ++  Q+   Q+   +EL + +S  EH      +R Q L      + EL ++R   +
Sbjct: 1462 SLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDR---E 1518

Query: 1184 GERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSAC----------RLTTQCELLTQ 1233
             +R  L  +L  LE +   +E Q  Q+++  +QL    C          ++  Q +L+ +
Sbjct: 1519 TQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKE 1578

Query: 1234 LRSAQEEENRQLL----------AEVQALSRENREL------LERSLESRDHLHREQREY 1277
            L   +E +   L            E+QA S +  +L      L R L+ RD   + QRE 
Sbjct: 1579 LEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQ 1638

Query: 1278 LDQLNA----LRREKQKLVEKIMDQYRVLEPVPLPRTKKGSWLADKVKRLMRPRREGG 1331
            +++L      L ++ ++  +++M Q   ++ +   RT++   L + ++++    RE G
Sbjct: 1639 IEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERG 1696



 Score =  143 bits (361), Expect = 1e-33
 Identities = 312/1315 (23%), Positives = 531/1315 (40%), Gaps = 237/1315 (18%)

Query: 201  ELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQL 260
            ELE    SL  TLS + +E+ L   + A+ + ++E   LR +      A+G    L+   
Sbjct: 1049 ELEREKASL--TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQE---AQGEQKELS--- 1100

Query: 261  ANAKAQLRRLRQELEEKAELLLDSQAEV-QGLEAE-IRRLRQEAQALSGQAKRAELYRE- 317
                AQ+  LRQE++EK    L  +A++ + LEA  I   +  A   + +AK A+L    
Sbjct: 1101 ----AQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRL 1156

Query: 318  -------EAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKAL- 369
                   EA A  ++ G   + Q +L      LQ  +A  S  E    LSG  +++ ++ 
Sbjct: 1157 RSTESQLEALAAEQQPGNQAQAQAQLASLYSALQ--QALGSVCESRPELSGGGDSAPSVW 1214

Query: 370  -LEEQLEAARERCAR---LHETQRENLLLRTRLGEAHAEL-------DSLRHQVDQLAEE 418
             LE     AR    R   L     E   + + L + H +L       D LR QV +L E 
Sbjct: 1215 GLEPDQNGARSLFKRGPLLTALSAE--AVASALHKLHQDLWKTQQTRDVLRDQVQKLEER 1272

Query: 419  NVELELE----------LQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEA------GRLR 462
              + E E          LQR L        ++   G   SL+ E+ E          RLR
Sbjct: 1273 LTDTEAEKSQVHTELQDLQRQLSQ--NQEEKSKWEGKQNSLESELMELHETMASLQSRLR 1330

Query: 463  TLERENRELRGLLQVLQGQPGG--------QHPLLEAPREDPVLPVLEEAPQTPVAFDHS 514
              E +  E +G  ++LQ             Q  ++EA  +     +LEE  +T  +    
Sbjct: 1331 RAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKL 1390

Query: 515  PQGLVQKARDGGP-------------QALDLAPPALDSVLEASAECPQAPDSDPQEAESP 561
                V+  R+                +AL      L   L    E  +      QE E  
Sbjct: 1391 KNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQ 1450

Query: 562  --LQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQL 619
              +Q AA++  + D   +     ++ ++  E    RS L+        +     +Q  Q+
Sbjct: 1451 REMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQI 1510

Query: 620  LGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGL--DLATGQA 677
               E + RE  +  L            EH+    E     +E Q G  Q L   L T + 
Sbjct: 1511 RELEKD-RETQRNVL------------EHQLLELEKKDQMIESQRGQVQDLKKQLVTLEC 1557

Query: 678  ---EAREHDQRLE---GTVRDPAWQKPQQK----------SEGALEVQVWEGPIPGESLA 721
               E  E+  ++E     +++   Q+  Q+           E + E+Q     I      
Sbjct: 1558 LALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESH 1617

Query: 722  SGVAEQE---------ALREEVAQLRRKAEALGDELEAQARKL----------EAQNTEA 762
            S V  +E         + RE++ +L+R+ E L  +LE + ++L          E Q T  
Sbjct: 1618 STVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQ 1677

Query: 763  AR-LSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAA 821
             + L ++L Q + +  E  RE   Q       R+ ++   +E +  S+ +   +E +   
Sbjct: 1678 TKILEEDLEQIKLSLRERGRELTTQ-------RQLMQERAEEGKGPSKAQRGSLEHMKLI 1730

Query: 822  GRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERE---------RREKE--AL 870
             R++ +       +  Q E   E +Q L+ +  Q L+   R+         +RE+E   L
Sbjct: 1731 LRDKEK------EVECQQEHIHE-LQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVL 1783

Query: 871  QAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAA 930
            Q +L++A  +G+     L+    E ++A  +R + L   + + Q+ QG E+R++ +  A 
Sbjct: 1784 QQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADAL 1843

Query: 931  ATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAML 990
              + E+A M LK R  +L++   Q R+                                 
Sbjct: 1844 QGALEQAHMTLKERHGELQDHKEQARR--------------------------------- 1870

Query: 991  VAEKAALQG-QLQHLEGQLGSLQGRAQE-----LLLQSQ---RAQEHSSRLQA-EKSVLE 1040
            + E+ A++G ++Q LE  LG L+  ++E     L LQ Q   +AQEH    +A + S L+
Sbjct: 1871 LEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQ 1930

Query: 1041 IQG--QELHRKLEVLEEEVRAARQSQEETRGQ----QQALLRDHKALAQLQRR--QEAEL 1092
             Q   +E  ++LE L  E +++R  +E  R +    Q+AL + H AL   ++   ++AEL
Sbjct: 1931 AQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAEL 1990

Query: 1093 -EGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQ 1151
               L      L+A++ A +   R+L+   E L+ Q   ++ Q++    + ++L Q    Q
Sbjct: 1991 SRSLEASTATLQASLDACQAHSRQLE---EALRIQEGEIQDQDLRYQEDVQQL-QQALAQ 2046

Query: 1152 RGLEEELRRLQS-----EHDRAQMLLAELSRERGELQGERGE-----LRGRLARLELERA 1201
            R  +EELR  Q      E   AQ +   + +E+  L  ER E     L   +  L+L  A
Sbjct: 2047 R--DEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLA 2104

Query: 1202 QLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLE 1261
            Q E +  +LRE+ Q+ +L A   + +        S  EE++ +L +    L RE  E L+
Sbjct: 2105 QKEQEILELRETQQRNNLEALPHSHK-------TSPMEEQSLKLDSLEPRLQRE-LERLQ 2156

Query: 1262 RSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRTKKGSWLADKVK 1321
             +L   +    E RE    L     + +  V  + +    L+   L R  +   L D+++
Sbjct: 2157 AALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELE 2216

Query: 1322 RLMRPRREGGPPGGLRLGADGAGSTESLGGPPETELPEGREADGTGSPSPAPMRR 1376
               R   +       RL + GA ST  LG   E  +  G  +     PSP  M +
Sbjct: 2217 LTRRALEKE------RLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEK 2265



 Score =  131 bits (330), Expect = 4e-30
 Identities = 277/1159 (23%), Positives = 470/1159 (40%), Gaps = 142/1159 (12%)

Query: 251  GPSHHLALQLANAKAQLRRLRQELE--EKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQ 308
            G    LA Q  + + ++  L +E E  +KA   L  Q EV  LE E  RLR+    L  Q
Sbjct: 442  GERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEV--LEQEAWRLRRVNVELQLQ 499

Query: 309  AKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQ-LEEERVLSGVLEAS- 366
               A+  +EE +     A R      E  R +E L   EA +S+ L E   L   LE+S 
Sbjct: 500  GDSAQGQKEEQQEELHLAVR------ERERLQEMLMGLEAKQSESLSELITLREALESSH 553

Query: 367  ---KALLEEQLE--AARERCAR-LHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENV 420
               + L +EQ E  AA  R  + + E       L+T + +  A    L    + LA + V
Sbjct: 554  LEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKV 613

Query: 421  ELELELQRSLEPPPGSPGEAPLA-GAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQ 479
             L  +L +  E           A  A  +LQ ++ EAE  R   L  +N  L   LQ  +
Sbjct: 614  GLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEK-RREALWEKNTHLEAQLQ--K 670

Query: 480  GQPGG---QHPLLEAPRE-DPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPP 535
             +  G   Q  L +   E + +   L E+     A     + L Q+A+    + L  A  
Sbjct: 671  AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAK-RQEEVLARAVQ 729

Query: 536  ALDSVLEASAECP---QAPDSDPQEAESPLQAAAMDP---QASDWSPQESGSPVE----- 584
              ++++   A      QA + D Q+    LQ  +      ++S +  Q+  S +E     
Sbjct: 730  EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789

Query: 585  --------TQESPEKAGRRSSLQSPASVAPPQGPGTK-IQAPQLLGGETEGREAPQGELV 635
                    TQ      G    L+        Q    +   A QL   E EG+ A + +  
Sbjct: 790  LEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKA 849

Query: 636  ---PEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDL----ATGQAEAREHDQRLEG 688
                E   LR++  + +    +  +  LE  E     L++       + EA +  +  E 
Sbjct: 850  AHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEER 909

Query: 689  TVRDPAWQKPQQKSEGALEVQVWEGPIPGE-SLASGVAEQEALREEVAQLRRKAEALGDE 747
            T  + A  + Q ++E    V + E  +  +  LA    + E LR+++   + K +     
Sbjct: 910  TQAESALCQMQLETEKE-RVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI 968

Query: 748  LEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQAR-LREAVEAAGQELES 806
            L+ Q ++ + +  EAAR  ++   A + E+ +  + +    +Q   L+  + A       
Sbjct: 969  LQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL 1028

Query: 807  ASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLE----------SEGRQH 856
              QE +  +       R +++ ERE + L       E+R+ VL+          S  RQ 
Sbjct: 1029 VEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQD 1088

Query: 857  LEEAERERREKEALQAELEKAVVRGKELG--ARLEHLQRELEQAALERQEFLREKESQHQ 914
            ++EA+ E++E  A Q EL +  V+ KE    A+   L  ELE + +  Q+      +Q  
Sbjct: 1089 MQEAQGEQKELSA-QMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEA 1147

Query: 915  RYQGLEQRL---EAELQAAATSKE-----EALMELKTRALQLEEEL---FQLRQGPAGLG 963
            +   L+ RL   E++L+A A  ++     +A  +L +    L++ L    + R   +G G
Sbjct: 1148 KAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGG 1207

Query: 964  PKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQ 1023
                +   L   QN      +R   +      A+   L  L   L   Q     L  Q Q
Sbjct: 1208 DSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQ 1267

Query: 1024 RAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQ 1083
            + +E  +  +AEKS +  + Q+L R+L   +EE       + +  G+Q +L         
Sbjct: 1268 KLEERLTDTEAEKSQVHTELQDLQRQLSQNQEE-------KSKWEGKQNSL--------- 1311

Query: 1084 LQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERER 1143
                 E+EL  L      L++ +R  EL   E QG  E LQA + ++ AQ   L A    
Sbjct: 1312 -----ESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVE 1366

Query: 1144 LMQDGHRQRGLEEELR-----------RLQSEHDRAQML-----------------LAEL 1175
                      LEE+LR            ++SE +RAQ L                 LA L
Sbjct: 1367 ARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALL 1426

Query: 1176 SRERGELQGERGELRGRLARL----ELERAQLEMQSQQLRESNQQLDLSACRL--TTQC- 1228
            ++   E + E   LRG++  L    E+++A LE+ S  L++ NQ++DL   ++    +C 
Sbjct: 1427 TQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCR 1486

Query: 1229 ELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREK 1288
             +L  L  A +E  ++L      + RE    LE+  E++ ++   Q   L++ + +   +
Sbjct: 1487 SVLEHLPMAVQEREQKL-----TVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQ 1541

Query: 1289 QKLVEKIMDQYRVLEPVPL 1307
            +  V+ +  Q   LE + L
Sbjct: 1542 RGQVQDLKKQLVTLECLAL 1560



 Score =  110 bits (276), Expect = 8e-24
 Identities = 160/635 (25%), Positives = 259/635 (40%), Gaps = 100/635 (15%)

Query: 726  EQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEA 785
            + +   EE   LR++ + L  E +  A +      E   LSKE    ++A  E  ++ E 
Sbjct: 422  QHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEV 481

Query: 786  QAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRA-QSEAAEE 844
               E  RLR        + +SA  ++E   E L  A RER + +     L A QSE+  E
Sbjct: 482  LEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSE 541

Query: 845  RMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRE---------- 894
             + + E+    HL E E  R+E+  + A L +A     EL +    L+ E          
Sbjct: 542  LITLREALESSHL-EGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVK 600

Query: 895  ---------LEQAALERQEFLREKESQH--QRYQGLEQ---------------------- 921
                     L++  L +Q    E+E+Q    R +  EQ                      
Sbjct: 601  LSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEK 660

Query: 922  --RLEAELQAAATSKEEA---LMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQ 976
               LEA+LQ A  +  E    L +++    +++++L + R        +     Q  + Q
Sbjct: 661  NTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ 720

Query: 977  NVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQEL-----LLQSQ--RAQEHS 1029
               L    +    LV EKAAL+ +LQ +E     L  + Q L     LL+S    AQ+ +
Sbjct: 721  EEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQN 780

Query: 1030 SRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQE 1089
            S ++  K  LE+Q Q + +  EV++ EVR  +   +  R Q +            Q R  
Sbjct: 781  SVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAE------------QERDA 828

Query: 1090 AELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGH 1149
            A                 A +LA  E +G+   L+ Q+A+ E +EV  L E+    +  H
Sbjct: 829  A-----------------ARQLAQAEQEGK-TALEQQKAAHE-KEVNQLREKWEKERSWH 869

Query: 1150 RQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQ 1209
            +Q  L + L  L+ E    +M L E   E   +Q +R E        E  +A+  +   Q
Sbjct: 870  QQE-LAKALESLEREKMELEMRLKEQQTEMEAIQAQREE--------ERTQAESALCQMQ 920

Query: 1210 LRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSL-ESRD 1268
            L    +++ L    L TQ EL     S Q E  RQ +   +   +E   +L+  L E++ 
Sbjct: 921  LETEKERVSLLETLLQTQKELAD--ASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQR 978

Query: 1269 HLHREQREYLDQLNALRREKQKLVEKIMDQYRVLE 1303
             L    R++ D L AL+ E   L++  MD  + +E
Sbjct: 979  ELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVE 1013



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 152/588 (25%), Positives = 247/588 (42%), Gaps = 79/588 (13%)

Query: 765  LSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRE 824
            L +++A+ + A     + ++     QA L   ++A   +  S  QE E  +EA    G  
Sbjct: 27   LQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEA--TGGPI 84

Query: 825  RRQWER-EGSRLRAQSEAAEERMQVLES------EGRQHLEEAERERREKEALQAELEKA 877
             ++WE  E   L       EE  Q  ES      + R H+E+A+   +   AL+ ++EK 
Sbjct: 85   PQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNK---ALREDVEKL 141

Query: 878  VVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRL---EAELQAAATSK 934
             V   +     + L R+  Q  +E++ F    + +H R   L + +           ++ 
Sbjct: 142  TV---DWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSAT 198

Query: 935  EEALMELKTRALQLEEELF----------QLRQGPAGLGPKKRAEPQ-----LVETQNVR 979
            +  LMELK   ++L   L           Q R+ P G G     EP      L +TQ + 
Sbjct: 199  DRDLMELKAEHVRLSGSLLTCCLRLTVGAQSRE-PNGSGRMDGREPAQLLLLLAKTQELE 257

Query: 980  LIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQEL---LLQSQRAQE-HSSRLQAE 1035
                ERS  ++  +    QG L+  E     LQ R  EL   L QSQ+  E +   ++A 
Sbjct: 258  KEAHERSQELIQLKS---QGDLEKAE-----LQDRVTELSALLTQSQKQNEDYEKMIKAL 309

Query: 1036 KSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQAL-------LRDHKALAQLQRRQ 1088
            +  +EI         E++E E   +R +QEE    QQ +       + +   +AQ    +
Sbjct: 310  RETVEILETN---HTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHE 366

Query: 1089 EA-ELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQD 1147
             + EL+  +    D +   +AL L    L  R + +Q  R     Q++A   E   L+Q 
Sbjct: 367  NSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLR-----QQLAGCQEAVNLLQQ 421

Query: 1148 GHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQS 1207
             H Q   EEE + L+         L +L+ ER  L G+  +L+G +  L  ER  L+   
Sbjct: 422  QHDQ--WEEEGKALRQR-------LQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAR 472

Query: 1208 QQLRESNQQLDLSACRL-TTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLES 1266
            ++LR+  + L+  A RL     EL  Q  SAQ ++  Q   E   L+   RE L+  L  
Sbjct: 473  EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQ--QEELHLAVRERERLQEMLMG 530

Query: 1267 RDHLHREQREYLDQLNALRR--EKQKLVEKIMDQYRVLEPVPLPRTKK 1312
               L  +Q E L +L  LR   E   L  +++ Q +      L R ++
Sbjct: 531  ---LEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 223/911 (24%), Positives = 360/911 (39%), Gaps = 129/911 (14%)

Query: 130  EEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQS-ELAAAIQEVTQ-PGAGVVL 187
            EE   ++E   +L+     Q E + + + H+  L LE +S EL A   ++        VL
Sbjct: 1563 EENHHKMECQQKLIKELEGQRETQRVALTHLT-LDLEERSQELQAQSSQIHDLESHSTVL 1621

Query: 188  ALSGPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLA----ELLLEREPLCLRPEA 243
            A       EL   + E+  +S    + +L R+++   Q L     EL+L++E + +  + 
Sbjct: 1622 AR------ELQERDQEV--KSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQ 1673

Query: 244  PSRAPA--EGPSHHLALQLANAKAQLRRLRQELEEKAE------------------LLLD 283
             +R     E     + L L     +L   RQ ++E+AE                  +L D
Sbjct: 1674 RTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRD 1733

Query: 284  SQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEA---LRERAGRLPRLQEELRRCR 340
             + EV+  +  I  L++    L  Q +   L+R+  E    L +R   +  LQ++L+  R
Sbjct: 1734 KEKEVECQQEHIHELQELKDQLEQQLQG--LHRKVGETSLLLSQREQEIVVLQQQLQEAR 1791

Query: 341  ERLQAAE-AYKSQLEE-ERVLSGVLEASKALLEEQLEA------ARERCARLHET-QREN 391
            E+ +  E + +SQL+E +R L+   +  +AL +EQ +A       +E+   L    ++ +
Sbjct: 1792 EQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAH 1851

Query: 392  LLLRTRLGEAHAELDSLRHQVDQLAEE--NVELELELQRSLEPPPGSPGEAPLAGAAPSL 449
            + L+ R GE     +  R   ++LA E   V+   E+   L        +A LA     L
Sbjct: 1852 MTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLA-----L 1906

Query: 450  QDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPR-EDPVLPVLEEAPQTP 508
            Q +  E    + +  E E R L+      Q     +   LEA R E       EEA +  
Sbjct: 1907 QQQCAE----QAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARAR 1962

Query: 509  VAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAP----DSDPQEAESPLQA 564
                    G    A  G  Q L L    L   LEAS    QA      +  ++ E  L+ 
Sbjct: 1963 AEALQEALGKAHAALQGKEQHL-LEQAELSRSLEASTATLQASLDACQAHSRQLEEALRI 2021

Query: 565  AAMDPQASDWSPQESGSPVE---TQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLG 621
               + Q  D   QE    ++    Q   E   ++   Q        +     IQ  Q LG
Sbjct: 2022 QEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLG 2081

Query: 622  GETEGREAPQGELVPEAWGLRQEGPEHK--PGPSEPSSVQLEEQEGPNQGLDLATGQAEA 679
             E E  E           GL Q   E +      E   ++L E +  N    L      +
Sbjct: 2082 QEREEEEIR---------GLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTS 2132

Query: 680  REHDQRLEGTVRDPAWQKPQQKSEGAL---EVQVWEGPIPGESLASGVAEQEALREEVAQ 736
               +Q L+    +P  Q+  ++ + AL   E +  E     + LA  +A+ +A    V+ 
Sbjct: 2133 PMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKA---SVSS 2189

Query: 737  LRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREA 796
            L+  A  L      QA  LE +++E  RL  EL   RRA  E  R     A   A L   
Sbjct: 2190 LQEVAMFL------QASVLE-RDSEQQRLQDELELTRRA-LEKERLHSPGATSTAELGSR 2241

Query: 797  VEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLR---AQSEAAEERMQVLESEG 853
             E   Q  E +  E E      +  G E++ W +    L+   A+ E    R+Q    + 
Sbjct: 2242 GEQGVQLGEVSGVEAEP-----SPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQL 2296

Query: 854  RQHLEEAERERR--EKEALQA------ELEKAVV--------RGK---------ELGARL 888
            R  LE+ ERERR  ++EA++A      E+ KA          RG+         EL   +
Sbjct: 2297 RSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEV 2356

Query: 889  EHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQL 948
              LQ +L     ++Q+++       +   GL   L   L A A + E  ++E +TR  +L
Sbjct: 2357 VLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETR--RL 2414

Query: 949  EEELFQLRQGP 959
            +E L Q    P
Sbjct: 2415 DESLTQSLTSP 2425



 Score = 38.5 bits (88), Expect = 0.048
 Identities = 66/282 (23%), Positives = 113/282 (40%), Gaps = 46/282 (16%)

Query: 1052 VLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANM-RALE 1110
            VLEE+V A +Q   E +      L++ +   Q Q     +L+  ++++R     + + LE
Sbjct: 19   VLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLE 78

Query: 1111 LAHRELQGRHEQLQAQ-------RASVEAQEVALLAE-----RERLMQDGHRQRGLEEEL 1158
                 +  R E ++         R   E Q    LAE     R  + +     + L E++
Sbjct: 79   ATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDV 138

Query: 1159 RRLQSEHDRAQMLLAELSRERGELQGE----RGELRGRLARL--------ELERAQLEMQ 1206
             +L  +  RA+    EL R+  + Q E    +G L+G   RL           R  LEM+
Sbjct: 139  EKLTVDWSRAR---DELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMK 195

Query: 1207 SQQLRE----SNQQLDLSACRLTTQCELLTQLRSAQEEENRQ-----------LLAEVQA 1251
            S   R+      + + LS   LT    L    +S +   + +           LLA+ Q 
Sbjct: 196  SATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQE 255

Query: 1252 LSRENRELLERSLESRDHLHREQREYLD---QLNALRREKQK 1290
            L +E  E  +  ++ +     E+ E  D   +L+AL  + QK
Sbjct: 256  LEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQK 297


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score =  155 bits (392), Expect = 3e-37
 Identities = 264/1119 (23%), Positives = 439/1119 (39%), Gaps = 190/1119 (16%)

Query: 258  LQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQ--------- 308
            LQ+      L+   QEL++  EL   S  EV  L+  + +L +E   L+ Q         
Sbjct: 870  LQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCA 929

Query: 309  ----------AKRAEL----------YREEAEALRERAGRLPRLQEELRRCRERLQAAEA 348
                      A++ EL            EE E  R+      RLQ+ ++     L+A E 
Sbjct: 930  EAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 989

Query: 349  YKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSL 408
             + +L+ E+V +   EA     EE L    ++ ++L    +E  LL  RL E  ++    
Sbjct: 990  ARQKLQLEKVTT---EAKMKKFEEDLLLLEDQNSKL---SKERKLLEDRLAEFSSQAAEE 1043

Query: 409  RHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLEREN 468
              +V  L +  ++ E  +                      ++D +R+ E GR + LE+  
Sbjct: 1044 EEKVKSLNKLRLKYEATIA--------------------DMEDRLRKEEKGR-QELEKLK 1082

Query: 469  RELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQ 528
            R L G    LQ Q   Q    E  R    L   EE  Q  +A          +A D G  
Sbjct: 1083 RRLDGESSELQEQMVEQQQRAEELRAQ--LGRKEEELQAALA----------RAEDEGGA 1130

Query: 529  ALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQES 588
               L    L S+ EA A   +A +    E  +  +A   + Q  D   +      E +++
Sbjct: 1131 RAQL----LKSLREAQAALAEAQEDLESERVARTKA---EKQRRDLGEELEALRGELEDT 1183

Query: 589  PEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEH 648
             +    +  L+S       +   T  +  ++     +      G+ + E     ++    
Sbjct: 1184 LDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG 1243

Query: 649  KPGPSEPSSVQLEEQEGPNQG--LDLATGQAEAREHDQRLE---GTVRDPAWQKPQQKSE 703
            K G  E + + LE +    +     L T + E  +  +RLE     V+  A    + ++E
Sbjct: 1244 K-GAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAE 1302

Query: 704  GALEVQVWEGPIPGESLASGVAEQEALR------EEVAQLRRKAEALGDELEAQ---ARK 754
             A ++Q  +  +   S A   AE + +R         AQL    E L +E  A+     +
Sbjct: 1303 AAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSR 1362

Query: 755  LEAQNTEAARLSKELAQARRAEAEAHRE---AEAQAWEQARLRE----AVEAAGQELESA 807
            + A   EAA L ++L +   A   A RE   A+AQ  E  R +E    A+EA  +    A
Sbjct: 1363 VRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRA 1422

Query: 808  SQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREK 867
            ++E EAL + LA       + ER   R R Q E  +  M +   + RQ +   E+++R+ 
Sbjct: 1423 AREAEALTQRLAEKTETVDRLER--GRRRLQQELDDATMDL--EQQRQLVSTLEKKQRKF 1478

Query: 868  EALQAE-----------LEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRY 916
            + L AE            E+A   G+E  AR   L R LE+    R+E  R+  +     
Sbjct: 1479 DQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAEL 1538

Query: 917  QGLEQRLE------AELQAAATSKEEALMELKTRALQLEEEL-----FQLR--------- 956
            + L    +       EL+ A    E+A  +L+ +  +LE+EL      +LR         
Sbjct: 1539 EALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALK 1598

Query: 957  -------QGPAGLGPKKRAE-PQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQL 1008
                   QG    G ++R +  + +    V   E  +   + VA +  L+G+L+ L+ Q+
Sbjct: 1599 TQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQM 1658

Query: 1009 GSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETR 1068
             S  G+ +E               +A K + ++Q Q     ++ L  EV   R S+EE  
Sbjct: 1659 AS-AGQGKE---------------EAVKQLRKMQAQ-----MKELWREVEETRTSREEIF 1697

Query: 1069 GQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRA 1128
             Q               R  E  L+GL      L+  + A + A R+ Q   +++  + A
Sbjct: 1698 SQ--------------NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVA 1743

Query: 1129 SVEAQEVALLAERERLM-QDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERG 1187
            +    + A+L E+ +L  + G  +  LEEE    +  +DR + LL ++     EL  E  
Sbjct: 1744 NGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAE-- 1801

Query: 1188 ELRGRLARLELERAQLEMQSQQLRESNQQLDLSA-----CRLTTQCELLTQLRSAQEEEN 1242
              R   A+ E  R QLE Q Q+LR    + D  A       +      L Q     E+E 
Sbjct: 1802 --RSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQET 1859

Query: 1243 RQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQL 1281
            R+ +   + + R  + L E  L+       E+R   DQL
Sbjct: 1860 RERILSGKLVRRAEKRLKEVVLQV-----EEERRVADQL 1893



 Score =  132 bits (333), Expect = 2e-30
 Identities = 274/1071 (25%), Positives = 423/1071 (39%), Gaps = 224/1071 (20%)

Query: 214  SKLARERDLGAQRLAE-----------------LLLEREPLC------LRPEAPSRAPAE 250
            SKL++ER L   RLAE                 L L+ E         LR E   R   E
Sbjct: 1020 SKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE 1079

Query: 251  -------GPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQ---GLEAEIRRLRQ 300
                   G S  L  Q+   + +   LR +L  K E L  + A  +   G  A++ +  +
Sbjct: 1080 KLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLR 1139

Query: 301  EAQALSGQAK-----------RAELYR----EEAEALR---ERAGRLPRLQEELRRCRER 342
            EAQA   +A+           +AE  R    EE EALR   E        Q+ELR  RE+
Sbjct: 1140 EAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQ 1199

Query: 343  LQAAEAYKSQLEEERVLSGVLEA-----SKAL--LEEQLEAARERCARLHETQRENLLLR 395
             +  E  K+  EE R+    ++       +AL  L EQLE AR       +T+   L L 
Sbjct: 1200 -EVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTR---LALE 1255

Query: 396  TRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVRE 455
              + E  AEL SL+    +  +    LEL+LQ  ++   G  GE   A AA  LQ    E
Sbjct: 1256 AEVSELRAELSSLQTARQEGEQRRRRLELQLQ-EVQGRAGD-GERARAEAAEKLQRAQAE 1313

Query: 456  AEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSP 515
             E       E E++ +R L + L       H   E         +L+E  +  +A     
Sbjct: 1314 LENVSGALNEAESKTIR-LSKELSSTEAQLHDAQE---------LLQEETRAKLA----- 1358

Query: 516  QGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWS 575
              L  + R     A++     L   LE  A   +    + Q A++         Q S+W 
Sbjct: 1359 --LGSRVR-----AMEAEAAGLREQLEEEAAARERAGRELQTAQA---------QLSEWR 1402

Query: 576  PQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELV 635
             ++        E+ E+A RR++ ++ A     Q    K +    L     GR   Q EL 
Sbjct: 1403 RRQE-EEAGALEAGEEARRRAAREAEALT---QRLAEKTETVDRL---ERGRRRLQQEL- 1454

Query: 636  PEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRL---EGTVRD 692
                              + +++ LE+Q        ++T + + R+ DQ L   +  V  
Sbjct: 1455 ------------------DDATMDLEQQRQL-----VSTLEKKQRKFDQLLAEEKAAVLR 1491

Query: 693  PAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQA 752
               ++ + ++EG       E      SL   + E++  REE   L R+  AL  ELEA  
Sbjct: 1492 AVEERERAEAEGR------EREARALSLTRALEEEQEAREE---LERQNRALRAELEA-- 1540

Query: 753  RKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQERE 812
              L +   +  +   EL +A R   +A  +  AQ  E   L + + AA    E A    E
Sbjct: 1541 --LLSSKDDVGKSVHELERACRVAEQAANDLRAQVTE---LEDELTAA----EDAKLRLE 1591

Query: 813  ALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQA 872
              V+AL      + Q ER+   L+ + EA EER + L  + R    E + ER+++     
Sbjct: 1592 VTVQAL------KTQHERD---LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTL--- 1639

Query: 873  ELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAAT 932
                AV   K+L   LE L+ ++  A   ++E ++    Q ++ Q   + L  E++   T
Sbjct: 1640 ----AVAARKKLEGELEELKAQMASAGQGKEEAVK----QLRKMQAQMKELWREVEETRT 1691

Query: 933  SKEEAL---MELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAM 989
            S+EE      E + R   LE E+ +L++    L    RA  Q  + ++    EV   N  
Sbjct: 1692 SREEIFSQNRESEKRLKGLEAEVLRLQE---ELAASDRARRQAQQDRDEMADEVANGN-- 1746

Query: 990  LVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRK 1049
                KAA+  + + LEG+LG L+   +E               Q+   +L  + ++L  +
Sbjct: 1747 --LSKAAILEEKRQLEGRLGQLEEELEE--------------EQSNSELLNDRYRKLLLQ 1790

Query: 1050 LEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRAL 1109
            +E L  E+ A R    +    +Q L R    + +L+ R   E  G   RH   K  + AL
Sbjct: 1791 VESLTTELSAERSFSAKAESGRQQLERQ---IQELRGRLGEEDAGARARH---KMTIAAL 1844

Query: 1110 E--LAHRELQGRHEQLQ-------AQRASVEAQEVALLAERERLMQDGHRQR-------- 1152
            E  LA  E Q   E  +        +RA    +EV L  E ER + D  R +        
Sbjct: 1845 ESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRV 1904

Query: 1153 --------GLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLAR 1195
                      EEE  R Q+   R Q  L +++     +  E   LR RL R
Sbjct: 1905 KQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1955



 Score =  117 bits (292), Expect = 1e-25
 Identities = 178/685 (25%), Positives = 291/685 (42%), Gaps = 93/685 (13%)

Query: 685  RLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGES--LASGVAEQEALREEV-AQLRRKA 741
            + E T+ D    + +++ +G  E++  +  + GES  L   + EQ+   EE+ AQL RK 
Sbjct: 1056 KYEATIADME-DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKE 1114

Query: 742  EALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAG 801
            E    EL+A   + E +    A+L K L +A+ A AEA  + E++   + +  +     G
Sbjct: 1115 E----ELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLG 1170

Query: 802  QELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQH----- 856
            +ELE+   E E  +++  A    R + E+E + L+   E      +    E RQ      
Sbjct: 1171 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL 1230

Query: 857  ---LEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEF-LREKESQ 912
                E+ E+ RR K A +           EL A L  LQ   ++    R+   L+ +E Q
Sbjct: 1231 GELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQ 1290

Query: 913  HQRYQGLEQRLEA--ELQAAATSKEE---ALMELKTRALQLEEELF----QLRQGPAGLG 963
             +   G   R EA  +LQ A    E    AL E +++ ++L +EL     QL      L 
Sbjct: 1291 GRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQ 1350

Query: 964  PKKRAEPQLVETQNVRLIEVERSNA--MLVAEKAALQG---QLQHLEGQLGSLQGRAQEL 1018
             + RA+  L     VR +E E +     L  E AA +    +LQ  + QL   + R +E 
Sbjct: 1351 EETRAK--LALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEE 1408

Query: 1019 LLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRG-----QQQA 1073
                +  +E   R   E   L    Q L  K E ++   R  R+ Q+E        +QQ 
Sbjct: 1409 AGALEAGEEARRRAAREAEALT---QRLAEKTETVDRLERGRRRLQQELDDATMDLEQQR 1465

Query: 1074 ---------------LLRDHKA--LAQLQRRQEAELEGLLVRHRDLKANMRALELAHREL 1116
                           LL + KA  L  ++ R+ AE EG     R+ +A   +L  A  E 
Sbjct: 1466 QLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG-----REREARALSLTRALEEE 1520

Query: 1117 QGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRG------------------LEEEL 1158
            Q   E+L+ Q  ++ A+  ALL+ ++ + +  H                      LE+EL
Sbjct: 1521 QEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1580

Query: 1159 RRLQSEHDRAQMLLAEL-SRERGELQG--ERGELRGRLARLELERAQLEMQSQQLRESNQ 1215
               +    R ++ +  L ++   +LQG  E GE R R    +L  A++E       E  Q
Sbjct: 1581 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDE----ERKQ 1636

Query: 1216 QLDLSACRLTTQCEL---LTQLRSAQE--EENRQLLAEVQALSRENRELLERSLESRDHL 1270
            +    A R   + EL     Q+ SA +  EE  + L ++QA  +E    +E +  SR+ +
Sbjct: 1637 RTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEI 1696

Query: 1271 HREQREYLDQLNALRREKQKLVEKI 1295
              + RE   +L  L  E  +L E++
Sbjct: 1697 FSQNRESEKRLKGLEAEVLRLQEEL 1721



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 209/887 (23%), Positives = 339/887 (38%), Gaps = 118/887 (13%)

Query: 131  EAVEQLEGVLRLLLGAS-VQCEHRELFIRHIQGLSLEVQSELA---AAIQEVTQPGAGVV 186
            E +E L G L   L ++  Q E R    + +  L   ++ E     AA+QE+ Q     +
Sbjct: 1171 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL 1230

Query: 187  LALS--------GPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLC 238
              L+        G    E     LE     L   LS L   R  G QR   L L+ + + 
Sbjct: 1231 GELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQ 1290

Query: 239  LRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRR- 297
             R     RA AE      A +L  A+A+L  +   L E     +    E+   EA++   
Sbjct: 1291 GRAGDGERARAEA-----AEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDA 1345

Query: 298  ---LRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEEL---RRCRERLQAAEA--- 348
               L++E +A      R      EA  LRE+      L+EE     R    LQ A+A   
Sbjct: 1346 QELLQEETRAKLALGSRVRAMEAEAAGLREQ------LEEEAAARERAGRELQTAQAQLS 1399

Query: 349  -YKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDS 407
             ++ + EEE   +G LEA         E AR R AR  E       L  RL E    +D 
Sbjct: 1400 EWRRRQEEE---AGALEAG--------EEARRRAAREAEA------LTQRLAEKTETVDR 1442

Query: 408  LRHQVDQLAEE--NVELELELQRSLEPPPGSPG---EAPLAGAAPSLQDEVREAEAGRLR 462
            L     +L +E  +  ++LE QR L           +  LA    ++   V E E     
Sbjct: 1443 LERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAE 1502

Query: 463  TLERENRELRGLLQVLQGQPGGQHPLLEAPRE-----DPVLPVLEEAPQTPVAFDHSPQG 517
              ERE R L  L + L+ +   +  L    R      + +L   ++  ++    + + + 
Sbjct: 1503 GREREARAL-SLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1561

Query: 518  LVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQ 577
              Q A D   Q  +L    L +  +A         +   + E  LQ      +A +   +
Sbjct: 1562 AEQAANDLRAQVTELEDE-LTAAEDAKLRLEVTVQALKTQHERDLQGR---DEAGEERRR 1617

Query: 578  ESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGEL--- 634
            +    +   E      R+    + A+    +G   +++A     G+  G+E    +L   
Sbjct: 1618 QLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQ--GKEEAVKQLRKM 1675

Query: 635  ---VPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVR 691
               + E W   +E  E +    E  S Q  E E   +GL+     AE     + L  + R
Sbjct: 1676 QAQMKELW---REVEETRTSREEIFS-QNRESEKRLKGLE-----AEVLRLQEELAASDR 1726

Query: 692  DPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQ 751
                Q  Q + E A EV            A+G   + A+ EE  QL  +   L +ELE +
Sbjct: 1727 ARR-QAQQDRDEMADEV------------ANGNLSKAAILEEKRQLEGRLGQLEEELEEE 1773

Query: 752  ARKLEAQNTEAARLSKELAQ-ARRAEAEAHREAEAQAWEQARLREAVEAAGQ--ELESAS 808
                E  N    +L  ++        AE    A+A++  Q   R+  E  G+  E ++ +
Sbjct: 1774 QSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGA 1833

Query: 809  QERE-----ALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERE 863
            + R      AL   LA A  +  Q  RE          AE+R+       ++ + + E E
Sbjct: 1834 RARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRL-------KEVVLQVEEE 1886

Query: 864  RREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRL 923
            RR  + L+ +LEK  +R K+L  +LE  + E  +A   R+   RE E   +  + + +  
Sbjct: 1887 RRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNR-- 1944

Query: 924  EAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEP 970
              E+           +   TR ++   ++F+L +G A     + A+P
Sbjct: 1945 --EVTTLRNRLRRGPLTFTTRTVR---QVFRLEEGVASDEEAEEAQP 1986



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 62/247 (25%), Positives = 109/247 (44%), Gaps = 33/247 (13%)

Query: 1079 KALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRE---LQGRHEQLQAQRASVEAQEV 1135
            K L Q+ R+ E     L  R ++L+      + + RE   LQGR  QL+ +RA +  Q  
Sbjct: 867  KPLLQVTRQDEV----LQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQ-- 920

Query: 1136 ALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLAR 1195
             L AE E L  +    RG      RL +     +++++EL    GE +    +++    R
Sbjct: 921  -LRAEAE-LCAEAEETRG------RLAARKQELELVVSELEARVGEEEECSRQMQTEKKR 972

Query: 1196 LELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRE 1255
            L+    +LE   +    + Q+L L         ++ T+ +  + EE+  LL +  +   +
Sbjct: 973  LQQHIQELEAHLEAEEGARQKLQLE--------KVTTEAKMKKFEEDLLLLEDQNSKLSK 1024

Query: 1256 NRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRTKKGSW 1315
             R+LLE  L        E+ E +  LN LR + +  +  + D+ R        + +KG  
Sbjct: 1025 ERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLR--------KEEKGRQ 1076

Query: 1316 LADKVKR 1322
              +K+KR
Sbjct: 1077 ELEKLKR 1083


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score =  155 bits (392), Expect = 3e-37
 Identities = 264/1119 (23%), Positives = 439/1119 (39%), Gaps = 190/1119 (16%)

Query: 258  LQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQ--------- 308
            LQ+      L+   QEL++  EL   S  EV  L+  + +L +E   L+ Q         
Sbjct: 862  LQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCA 921

Query: 309  ----------AKRAEL----------YREEAEALRERAGRLPRLQEELRRCRERLQAAEA 348
                      A++ EL            EE E  R+      RLQ+ ++     L+A E 
Sbjct: 922  EAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 981

Query: 349  YKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSL 408
             + +L+ E+V +   EA     EE L    ++ ++L    +E  LL  RL E  ++    
Sbjct: 982  ARQKLQLEKVTT---EAKMKKFEEDLLLLEDQNSKL---SKERKLLEDRLAEFSSQAAEE 1035

Query: 409  RHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLEREN 468
              +V  L +  ++ E  +                      ++D +R+ E GR + LE+  
Sbjct: 1036 EEKVKSLNKLRLKYEATIA--------------------DMEDRLRKEEKGR-QELEKLK 1074

Query: 469  RELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQ 528
            R L G    LQ Q   Q    E  R    L   EE  Q  +A          +A D G  
Sbjct: 1075 RRLDGESSELQEQMVEQQQRAEELRAQ--LGRKEEELQAALA----------RAEDEGGA 1122

Query: 529  ALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQES 588
               L    L S+ EA A   +A +    E  +  +A   + Q  D   +      E +++
Sbjct: 1123 RAQL----LKSLREAQAALAEAQEDLESERVARTKA---EKQRRDLGEELEALRGELEDT 1175

Query: 589  PEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEH 648
             +    +  L+S       +   T  +  ++     +      G+ + E     ++    
Sbjct: 1176 LDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG 1235

Query: 649  KPGPSEPSSVQLEEQEGPNQG--LDLATGQAEAREHDQRLE---GTVRDPAWQKPQQKSE 703
            K G  E + + LE +    +     L T + E  +  +RLE     V+  A    + ++E
Sbjct: 1236 K-GAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAE 1294

Query: 704  GALEVQVWEGPIPGESLASGVAEQEALR------EEVAQLRRKAEALGDELEAQ---ARK 754
             A ++Q  +  +   S A   AE + +R         AQL    E L +E  A+     +
Sbjct: 1295 AAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSR 1354

Query: 755  LEAQNTEAARLSKELAQARRAEAEAHRE---AEAQAWEQARLRE----AVEAAGQELESA 807
            + A   EAA L ++L +   A   A RE   A+AQ  E  R +E    A+EA  +    A
Sbjct: 1355 VRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRA 1414

Query: 808  SQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREK 867
            ++E EAL + LA       + ER   R R Q E  +  M +   + RQ +   E+++R+ 
Sbjct: 1415 AREAEALTQRLAEKTETVDRLER--GRRRLQQELDDATMDL--EQQRQLVSTLEKKQRKF 1470

Query: 868  EALQAE-----------LEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRY 916
            + L AE            E+A   G+E  AR   L R LE+    R+E  R+  +     
Sbjct: 1471 DQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAEL 1530

Query: 917  QGLEQRLE------AELQAAATSKEEALMELKTRALQLEEEL-----FQLR--------- 956
            + L    +       EL+ A    E+A  +L+ +  +LE+EL      +LR         
Sbjct: 1531 EALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALK 1590

Query: 957  -------QGPAGLGPKKRAE-PQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQL 1008
                   QG    G ++R +  + +    V   E  +   + VA +  L+G+L+ L+ Q+
Sbjct: 1591 TQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQM 1650

Query: 1009 GSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETR 1068
             S  G+ +E               +A K + ++Q Q     ++ L  EV   R S+EE  
Sbjct: 1651 AS-AGQGKE---------------EAVKQLRKMQAQ-----MKELWREVEETRTSREEIF 1689

Query: 1069 GQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRA 1128
             Q               R  E  L+GL      L+  + A + A R+ Q   +++  + A
Sbjct: 1690 SQ--------------NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVA 1735

Query: 1129 SVEAQEVALLAERERLM-QDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERG 1187
            +    + A+L E+ +L  + G  +  LEEE    +  +DR + LL ++     EL  E  
Sbjct: 1736 NGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAE-- 1793

Query: 1188 ELRGRLARLELERAQLEMQSQQLRESNQQLDLSA-----CRLTTQCELLTQLRSAQEEEN 1242
              R   A+ E  R QLE Q Q+LR    + D  A       +      L Q     E+E 
Sbjct: 1794 --RSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQET 1851

Query: 1243 RQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQL 1281
            R+ +   + + R  + L E  L+       E+R   DQL
Sbjct: 1852 RERILSGKLVRRAEKRLKEVVLQV-----EEERRVADQL 1885



 Score =  132 bits (333), Expect = 2e-30
 Identities = 274/1071 (25%), Positives = 423/1071 (39%), Gaps = 224/1071 (20%)

Query: 214  SKLARERDLGAQRLAE-----------------LLLEREPLC------LRPEAPSRAPAE 250
            SKL++ER L   RLAE                 L L+ E         LR E   R   E
Sbjct: 1012 SKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE 1071

Query: 251  -------GPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQ---GLEAEIRRLRQ 300
                   G S  L  Q+   + +   LR +L  K E L  + A  +   G  A++ +  +
Sbjct: 1072 KLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLR 1131

Query: 301  EAQALSGQAK-----------RAELYR----EEAEALR---ERAGRLPRLQEELRRCRER 342
            EAQA   +A+           +AE  R    EE EALR   E        Q+ELR  RE+
Sbjct: 1132 EAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQ 1191

Query: 343  LQAAEAYKSQLEEERVLSGVLEA-----SKAL--LEEQLEAARERCARLHETQRENLLLR 395
             +  E  K+  EE R+    ++       +AL  L EQLE AR       +T+   L L 
Sbjct: 1192 -EVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTR---LALE 1247

Query: 396  TRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVRE 455
              + E  AEL SL+    +  +    LEL+LQ  ++   G  GE   A AA  LQ    E
Sbjct: 1248 AEVSELRAELSSLQTARQEGEQRRRRLELQLQ-EVQGRAGD-GERARAEAAEKLQRAQAE 1305

Query: 456  AEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSP 515
             E       E E++ +R L + L       H   E         +L+E  +  +A     
Sbjct: 1306 LENVSGALNEAESKTIR-LSKELSSTEAQLHDAQE---------LLQEETRAKLA----- 1350

Query: 516  QGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWS 575
              L  + R     A++     L   LE  A   +    + Q A++         Q S+W 
Sbjct: 1351 --LGSRVR-----AMEAEAAGLREQLEEEAAARERAGRELQTAQA---------QLSEWR 1394

Query: 576  PQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELV 635
             ++        E+ E+A RR++ ++ A     Q    K +    L     GR   Q EL 
Sbjct: 1395 RRQE-EEAGALEAGEEARRRAAREAEALT---QRLAEKTETVDRL---ERGRRRLQQEL- 1446

Query: 636  PEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRL---EGTVRD 692
                              + +++ LE+Q        ++T + + R+ DQ L   +  V  
Sbjct: 1447 ------------------DDATMDLEQQRQL-----VSTLEKKQRKFDQLLAEEKAAVLR 1483

Query: 693  PAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQA 752
               ++ + ++EG       E      SL   + E++  REE   L R+  AL  ELEA  
Sbjct: 1484 AVEERERAEAEGR------EREARALSLTRALEEEQEAREE---LERQNRALRAELEA-- 1532

Query: 753  RKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQERE 812
              L +   +  +   EL +A R   +A  +  AQ  E   L + + AA    E A    E
Sbjct: 1533 --LLSSKDDVGKSVHELERACRVAEQAANDLRAQVTE---LEDELTAA----EDAKLRLE 1583

Query: 813  ALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQA 872
              V+AL      + Q ER+   L+ + EA EER + L  + R    E + ER+++     
Sbjct: 1584 VTVQAL------KTQHERD---LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTL--- 1631

Query: 873  ELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAAT 932
                AV   K+L   LE L+ ++  A   ++E ++    Q ++ Q   + L  E++   T
Sbjct: 1632 ----AVAARKKLEGELEELKAQMASAGQGKEEAVK----QLRKMQAQMKELWREVEETRT 1683

Query: 933  SKEEAL---MELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAM 989
            S+EE      E + R   LE E+ +L++    L    RA  Q  + ++    EV   N  
Sbjct: 1684 SREEIFSQNRESEKRLKGLEAEVLRLQE---ELAASDRARRQAQQDRDEMADEVANGN-- 1738

Query: 990  LVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRK 1049
                KAA+  + + LEG+LG L+   +E               Q+   +L  + ++L  +
Sbjct: 1739 --LSKAAILEEKRQLEGRLGQLEEELEE--------------EQSNSELLNDRYRKLLLQ 1782

Query: 1050 LEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRAL 1109
            +E L  E+ A R    +    +Q L R    + +L+ R   E  G   RH   K  + AL
Sbjct: 1783 VESLTTELSAERSFSAKAESGRQQLERQ---IQELRGRLGEEDAGARARH---KMTIAAL 1836

Query: 1110 E--LAHRELQGRHEQLQ-------AQRASVEAQEVALLAERERLMQDGHRQR-------- 1152
            E  LA  E Q   E  +        +RA    +EV L  E ER + D  R +        
Sbjct: 1837 ESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRV 1896

Query: 1153 --------GLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLAR 1195
                      EEE  R Q+   R Q  L +++     +  E   LR RL R
Sbjct: 1897 KQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1947



 Score =  117 bits (292), Expect = 1e-25
 Identities = 178/685 (25%), Positives = 291/685 (42%), Gaps = 93/685 (13%)

Query: 685  RLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGES--LASGVAEQEALREEV-AQLRRKA 741
            + E T+ D    + +++ +G  E++  +  + GES  L   + EQ+   EE+ AQL RK 
Sbjct: 1048 KYEATIADME-DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKE 1106

Query: 742  EALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAG 801
            E    EL+A   + E +    A+L K L +A+ A AEA  + E++   + +  +     G
Sbjct: 1107 E----ELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLG 1162

Query: 802  QELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQH----- 856
            +ELE+   E E  +++  A    R + E+E + L+   E      +    E RQ      
Sbjct: 1163 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL 1222

Query: 857  ---LEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEF-LREKESQ 912
                E+ E+ RR K A +           EL A L  LQ   ++    R+   L+ +E Q
Sbjct: 1223 GELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQ 1282

Query: 913  HQRYQGLEQRLEA--ELQAAATSKEE---ALMELKTRALQLEEELF----QLRQGPAGLG 963
             +   G   R EA  +LQ A    E    AL E +++ ++L +EL     QL      L 
Sbjct: 1283 GRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQ 1342

Query: 964  PKKRAEPQLVETQNVRLIEVERSNA--MLVAEKAALQG---QLQHLEGQLGSLQGRAQEL 1018
             + RA+  L     VR +E E +     L  E AA +    +LQ  + QL   + R +E 
Sbjct: 1343 EETRAK--LALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEE 1400

Query: 1019 LLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRG-----QQQA 1073
                +  +E   R   E   L    Q L  K E ++   R  R+ Q+E        +QQ 
Sbjct: 1401 AGALEAGEEARRRAAREAEALT---QRLAEKTETVDRLERGRRRLQQELDDATMDLEQQR 1457

Query: 1074 ---------------LLRDHKA--LAQLQRRQEAELEGLLVRHRDLKANMRALELAHREL 1116
                           LL + KA  L  ++ R+ AE EG     R+ +A   +L  A  E 
Sbjct: 1458 QLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG-----REREARALSLTRALEEE 1512

Query: 1117 QGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRG------------------LEEEL 1158
            Q   E+L+ Q  ++ A+  ALL+ ++ + +  H                      LE+EL
Sbjct: 1513 QEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1572

Query: 1159 RRLQSEHDRAQMLLAEL-SRERGELQG--ERGELRGRLARLELERAQLEMQSQQLRESNQ 1215
               +    R ++ +  L ++   +LQG  E GE R R    +L  A++E       E  Q
Sbjct: 1573 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDE----ERKQ 1628

Query: 1216 QLDLSACRLTTQCEL---LTQLRSAQE--EENRQLLAEVQALSRENRELLERSLESRDHL 1270
            +    A R   + EL     Q+ SA +  EE  + L ++QA  +E    +E +  SR+ +
Sbjct: 1629 RTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEI 1688

Query: 1271 HREQREYLDQLNALRREKQKLVEKI 1295
              + RE   +L  L  E  +L E++
Sbjct: 1689 FSQNRESEKRLKGLEAEVLRLQEEL 1713



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 209/887 (23%), Positives = 339/887 (38%), Gaps = 118/887 (13%)

Query: 131  EAVEQLEGVLRLLLGAS-VQCEHRELFIRHIQGLSLEVQSELA---AAIQEVTQPGAGVV 186
            E +E L G L   L ++  Q E R    + +  L   ++ E     AA+QE+ Q     +
Sbjct: 1163 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL 1222

Query: 187  LALS--------GPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLC 238
              L+        G    E     LE     L   LS L   R  G QR   L L+ + + 
Sbjct: 1223 GELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQ 1282

Query: 239  LRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRR- 297
             R     RA AE      A +L  A+A+L  +   L E     +    E+   EA++   
Sbjct: 1283 GRAGDGERARAEA-----AEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDA 1337

Query: 298  ---LRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEEL---RRCRERLQAAEA--- 348
               L++E +A      R      EA  LRE+      L+EE     R    LQ A+A   
Sbjct: 1338 QELLQEETRAKLALGSRVRAMEAEAAGLREQ------LEEEAAARERAGRELQTAQAQLS 1391

Query: 349  -YKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDS 407
             ++ + EEE   +G LEA         E AR R AR  E       L  RL E    +D 
Sbjct: 1392 EWRRRQEEE---AGALEAG--------EEARRRAAREAEA------LTQRLAEKTETVDR 1434

Query: 408  LRHQVDQLAEE--NVELELELQRSLEPPPGSPG---EAPLAGAAPSLQDEVREAEAGRLR 462
            L     +L +E  +  ++LE QR L           +  LA    ++   V E E     
Sbjct: 1435 LERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAE 1494

Query: 463  TLERENRELRGLLQVLQGQPGGQHPLLEAPRE-----DPVLPVLEEAPQTPVAFDHSPQG 517
              ERE R L  L + L+ +   +  L    R      + +L   ++  ++    + + + 
Sbjct: 1495 GREREARAL-SLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1553

Query: 518  LVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQ 577
              Q A D   Q  +L    L +  +A         +   + E  LQ      +A +   +
Sbjct: 1554 AEQAANDLRAQVTELEDE-LTAAEDAKLRLEVTVQALKTQHERDLQGR---DEAGEERRR 1609

Query: 578  ESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGEL--- 634
            +    +   E      R+    + A+    +G   +++A     G+  G+E    +L   
Sbjct: 1610 QLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQ--GKEEAVKQLRKM 1667

Query: 635  ---VPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVR 691
               + E W   +E  E +    E  S Q  E E   +GL+     AE     + L  + R
Sbjct: 1668 QAQMKELW---REVEETRTSREEIFS-QNRESEKRLKGLE-----AEVLRLQEELAASDR 1718

Query: 692  DPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQ 751
                Q  Q + E A EV            A+G   + A+ EE  QL  +   L +ELE +
Sbjct: 1719 ARR-QAQQDRDEMADEV------------ANGNLSKAAILEEKRQLEGRLGQLEEELEEE 1765

Query: 752  ARKLEAQNTEAARLSKELAQ-ARRAEAEAHREAEAQAWEQARLREAVEAAGQ--ELESAS 808
                E  N    +L  ++        AE    A+A++  Q   R+  E  G+  E ++ +
Sbjct: 1766 QSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGA 1825

Query: 809  QERE-----ALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERE 863
            + R      AL   LA A  +  Q  RE          AE+R+       ++ + + E E
Sbjct: 1826 RARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRL-------KEVVLQVEEE 1878

Query: 864  RREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRL 923
            RR  + L+ +LEK  +R K+L  +LE  + E  +A   R+   RE E   +  + + +  
Sbjct: 1879 RRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNR-- 1936

Query: 924  EAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEP 970
              E+           +   TR ++   ++F+L +G A     + A+P
Sbjct: 1937 --EVTTLRNRLRRGPLTFTTRTVR---QVFRLEEGVASDEEAEEAQP 1978



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 62/247 (25%), Positives = 109/247 (44%), Gaps = 33/247 (13%)

Query: 1079 KALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRE---LQGRHEQLQAQRASVEAQEV 1135
            K L Q+ R+ E     L  R ++L+      + + RE   LQGR  QL+ +RA +  Q  
Sbjct: 859  KPLLQVTRQDEV----LQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQ-- 912

Query: 1136 ALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLAR 1195
             L AE E L  +    RG      RL +     +++++EL    GE +    +++    R
Sbjct: 913  -LRAEAE-LCAEAEETRG------RLAARKQELELVVSELEARVGEEEECSRQMQTEKKR 964

Query: 1196 LELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRE 1255
            L+    +LE   +    + Q+L L         ++ T+ +  + EE+  LL +  +   +
Sbjct: 965  LQQHIQELEAHLEAEEGARQKLQLE--------KVTTEAKMKKFEEDLLLLEDQNSKLSK 1016

Query: 1256 NRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRTKKGSW 1315
             R+LLE  L        E+ E +  LN LR + +  +  + D+ R        + +KG  
Sbjct: 1017 ERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLR--------KEEKGRQ 1068

Query: 1316 LADKVKR 1322
              +K+KR
Sbjct: 1069 ELEKLKR 1075


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score =  155 bits (392), Expect = 3e-37
 Identities = 264/1119 (23%), Positives = 439/1119 (39%), Gaps = 190/1119 (16%)

Query: 258  LQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQ--------- 308
            LQ+      L+   QEL++  EL   S  EV  L+  + +L +E   L+ Q         
Sbjct: 903  LQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCA 962

Query: 309  ----------AKRAEL----------YREEAEALRERAGRLPRLQEELRRCRERLQAAEA 348
                      A++ EL            EE E  R+      RLQ+ ++     L+A E 
Sbjct: 963  EAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 1022

Query: 349  YKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSL 408
             + +L+ E+V +   EA     EE L    ++ ++L    +E  LL  RL E  ++    
Sbjct: 1023 ARQKLQLEKVTT---EAKMKKFEEDLLLLEDQNSKL---SKERKLLEDRLAEFSSQAAEE 1076

Query: 409  RHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLEREN 468
              +V  L +  ++ E  +                      ++D +R+ E GR + LE+  
Sbjct: 1077 EEKVKSLNKLRLKYEATIA--------------------DMEDRLRKEEKGR-QELEKLK 1115

Query: 469  RELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQ 528
            R L G    LQ Q   Q    E  R    L   EE  Q  +A          +A D G  
Sbjct: 1116 RRLDGESSELQEQMVEQQQRAEELRAQ--LGRKEEELQAALA----------RAEDEGGA 1163

Query: 529  ALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQES 588
               L    L S+ EA A   +A +    E  +  +A   + Q  D   +      E +++
Sbjct: 1164 RAQL----LKSLREAQAALAEAQEDLESERVARTKA---EKQRRDLGEELEALRGELEDT 1216

Query: 589  PEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEH 648
             +    +  L+S       +   T  +  ++     +      G+ + E     ++    
Sbjct: 1217 LDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG 1276

Query: 649  KPGPSEPSSVQLEEQEGPNQG--LDLATGQAEAREHDQRLE---GTVRDPAWQKPQQKSE 703
            K G  E + + LE +    +     L T + E  +  +RLE     V+  A    + ++E
Sbjct: 1277 K-GAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAE 1335

Query: 704  GALEVQVWEGPIPGESLASGVAEQEALR------EEVAQLRRKAEALGDELEAQ---ARK 754
             A ++Q  +  +   S A   AE + +R         AQL    E L +E  A+     +
Sbjct: 1336 AAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSR 1395

Query: 755  LEAQNTEAARLSKELAQARRAEAEAHRE---AEAQAWEQARLRE----AVEAAGQELESA 807
            + A   EAA L ++L +   A   A RE   A+AQ  E  R +E    A+EA  +    A
Sbjct: 1396 VRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRA 1455

Query: 808  SQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREK 867
            ++E EAL + LA       + ER   R R Q E  +  M +   + RQ +   E+++R+ 
Sbjct: 1456 AREAEALTQRLAEKTETVDRLER--GRRRLQQELDDATMDL--EQQRQLVSTLEKKQRKF 1511

Query: 868  EALQAE-----------LEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRY 916
            + L AE            E+A   G+E  AR   L R LE+    R+E  R+  +     
Sbjct: 1512 DQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAEL 1571

Query: 917  QGLEQRLE------AELQAAATSKEEALMELKTRALQLEEEL-----FQLR--------- 956
            + L    +       EL+ A    E+A  +L+ +  +LE+EL      +LR         
Sbjct: 1572 EALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALK 1631

Query: 957  -------QGPAGLGPKKRAE-PQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQL 1008
                   QG    G ++R +  + +    V   E  +   + VA +  L+G+L+ L+ Q+
Sbjct: 1632 TQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQM 1691

Query: 1009 GSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETR 1068
             S  G+ +E               +A K + ++Q Q     ++ L  EV   R S+EE  
Sbjct: 1692 AS-AGQGKE---------------EAVKQLRKMQAQ-----MKELWREVEETRTSREEIF 1730

Query: 1069 GQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRA 1128
             Q               R  E  L+GL      L+  + A + A R+ Q   +++  + A
Sbjct: 1731 SQ--------------NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVA 1776

Query: 1129 SVEAQEVALLAERERLM-QDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERG 1187
            +    + A+L E+ +L  + G  +  LEEE    +  +DR + LL ++     EL  E  
Sbjct: 1777 NGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAE-- 1834

Query: 1188 ELRGRLARLELERAQLEMQSQQLRESNQQLDLSA-----CRLTTQCELLTQLRSAQEEEN 1242
              R   A+ E  R QLE Q Q+LR    + D  A       +      L Q     E+E 
Sbjct: 1835 --RSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQET 1892

Query: 1243 RQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQL 1281
            R+ +   + + R  + L E  L+       E+R   DQL
Sbjct: 1893 RERILSGKLVRRAEKRLKEVVLQV-----EEERRVADQL 1926



 Score =  132 bits (333), Expect = 2e-30
 Identities = 274/1071 (25%), Positives = 423/1071 (39%), Gaps = 224/1071 (20%)

Query: 214  SKLARERDLGAQRLAE-----------------LLLEREPLC------LRPEAPSRAPAE 250
            SKL++ER L   RLAE                 L L+ E         LR E   R   E
Sbjct: 1053 SKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE 1112

Query: 251  -------GPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQ---GLEAEIRRLRQ 300
                   G S  L  Q+   + +   LR +L  K E L  + A  +   G  A++ +  +
Sbjct: 1113 KLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLR 1172

Query: 301  EAQALSGQAK-----------RAELYR----EEAEALR---ERAGRLPRLQEELRRCRER 342
            EAQA   +A+           +AE  R    EE EALR   E        Q+ELR  RE+
Sbjct: 1173 EAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQ 1232

Query: 343  LQAAEAYKSQLEEERVLSGVLEA-----SKAL--LEEQLEAARERCARLHETQRENLLLR 395
             +  E  K+  EE R+    ++       +AL  L EQLE AR       +T+   L L 
Sbjct: 1233 -EVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTR---LALE 1288

Query: 396  TRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVRE 455
              + E  AEL SL+    +  +    LEL+LQ  ++   G  GE   A AA  LQ    E
Sbjct: 1289 AEVSELRAELSSLQTARQEGEQRRRRLELQLQ-EVQGRAGD-GERARAEAAEKLQRAQAE 1346

Query: 456  AEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSP 515
             E       E E++ +R L + L       H   E         +L+E  +  +A     
Sbjct: 1347 LENVSGALNEAESKTIR-LSKELSSTEAQLHDAQE---------LLQEETRAKLA----- 1391

Query: 516  QGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWS 575
              L  + R     A++     L   LE  A   +    + Q A++         Q S+W 
Sbjct: 1392 --LGSRVR-----AMEAEAAGLREQLEEEAAARERAGRELQTAQA---------QLSEWR 1435

Query: 576  PQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELV 635
             ++        E+ E+A RR++ ++ A     Q    K +    L     GR   Q EL 
Sbjct: 1436 RRQE-EEAGALEAGEEARRRAAREAEALT---QRLAEKTETVDRL---ERGRRRLQQEL- 1487

Query: 636  PEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRL---EGTVRD 692
                              + +++ LE+Q        ++T + + R+ DQ L   +  V  
Sbjct: 1488 ------------------DDATMDLEQQRQL-----VSTLEKKQRKFDQLLAEEKAAVLR 1524

Query: 693  PAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQA 752
               ++ + ++EG       E      SL   + E++  REE   L R+  AL  ELEA  
Sbjct: 1525 AVEERERAEAEGR------EREARALSLTRALEEEQEAREE---LERQNRALRAELEA-- 1573

Query: 753  RKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQERE 812
              L +   +  +   EL +A R   +A  +  AQ  E   L + + AA    E A    E
Sbjct: 1574 --LLSSKDDVGKSVHELERACRVAEQAANDLRAQVTE---LEDELTAA----EDAKLRLE 1624

Query: 813  ALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQA 872
              V+AL      + Q ER+   L+ + EA EER + L  + R    E + ER+++     
Sbjct: 1625 VTVQAL------KTQHERD---LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTL--- 1672

Query: 873  ELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAAT 932
                AV   K+L   LE L+ ++  A   ++E ++    Q ++ Q   + L  E++   T
Sbjct: 1673 ----AVAARKKLEGELEELKAQMASAGQGKEEAVK----QLRKMQAQMKELWREVEETRT 1724

Query: 933  SKEEAL---MELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAM 989
            S+EE      E + R   LE E+ +L++    L    RA  Q  + ++    EV   N  
Sbjct: 1725 SREEIFSQNRESEKRLKGLEAEVLRLQE---ELAASDRARRQAQQDRDEMADEVANGN-- 1779

Query: 990  LVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRK 1049
                KAA+  + + LEG+LG L+   +E               Q+   +L  + ++L  +
Sbjct: 1780 --LSKAAILEEKRQLEGRLGQLEEELEE--------------EQSNSELLNDRYRKLLLQ 1823

Query: 1050 LEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRAL 1109
            +E L  E+ A R    +    +Q L R    + +L+ R   E  G   RH   K  + AL
Sbjct: 1824 VESLTTELSAERSFSAKAESGRQQLERQ---IQELRGRLGEEDAGARARH---KMTIAAL 1877

Query: 1110 E--LAHRELQGRHEQLQ-------AQRASVEAQEVALLAERERLMQDGHRQR-------- 1152
            E  LA  E Q   E  +        +RA    +EV L  E ER + D  R +        
Sbjct: 1878 ESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRV 1937

Query: 1153 --------GLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLAR 1195
                      EEE  R Q+   R Q  L +++     +  E   LR RL R
Sbjct: 1938 KQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1988



 Score =  117 bits (292), Expect = 1e-25
 Identities = 178/685 (25%), Positives = 291/685 (42%), Gaps = 93/685 (13%)

Query: 685  RLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGES--LASGVAEQEALREEV-AQLRRKA 741
            + E T+ D    + +++ +G  E++  +  + GES  L   + EQ+   EE+ AQL RK 
Sbjct: 1089 KYEATIADME-DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKE 1147

Query: 742  EALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAG 801
            E    EL+A   + E +    A+L K L +A+ A AEA  + E++   + +  +     G
Sbjct: 1148 E----ELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLG 1203

Query: 802  QELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQH----- 856
            +ELE+   E E  +++  A    R + E+E + L+   E      +    E RQ      
Sbjct: 1204 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL 1263

Query: 857  ---LEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEF-LREKESQ 912
                E+ E+ RR K A +           EL A L  LQ   ++    R+   L+ +E Q
Sbjct: 1264 GELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQ 1323

Query: 913  HQRYQGLEQRLEA--ELQAAATSKEE---ALMELKTRALQLEEELF----QLRQGPAGLG 963
             +   G   R EA  +LQ A    E    AL E +++ ++L +EL     QL      L 
Sbjct: 1324 GRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQ 1383

Query: 964  PKKRAEPQLVETQNVRLIEVERSNA--MLVAEKAALQG---QLQHLEGQLGSLQGRAQEL 1018
             + RA+  L     VR +E E +     L  E AA +    +LQ  + QL   + R +E 
Sbjct: 1384 EETRAK--LALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEE 1441

Query: 1019 LLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRG-----QQQA 1073
                +  +E   R   E   L    Q L  K E ++   R  R+ Q+E        +QQ 
Sbjct: 1442 AGALEAGEEARRRAAREAEALT---QRLAEKTETVDRLERGRRRLQQELDDATMDLEQQR 1498

Query: 1074 ---------------LLRDHKA--LAQLQRRQEAELEGLLVRHRDLKANMRALELAHREL 1116
                           LL + KA  L  ++ R+ AE EG     R+ +A   +L  A  E 
Sbjct: 1499 QLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG-----REREARALSLTRALEEE 1553

Query: 1117 QGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRG------------------LEEEL 1158
            Q   E+L+ Q  ++ A+  ALL+ ++ + +  H                      LE+EL
Sbjct: 1554 QEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1613

Query: 1159 RRLQSEHDRAQMLLAEL-SRERGELQG--ERGELRGRLARLELERAQLEMQSQQLRESNQ 1215
               +    R ++ +  L ++   +LQG  E GE R R    +L  A++E       E  Q
Sbjct: 1614 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDE----ERKQ 1669

Query: 1216 QLDLSACRLTTQCEL---LTQLRSAQE--EENRQLLAEVQALSRENRELLERSLESRDHL 1270
            +    A R   + EL     Q+ SA +  EE  + L ++QA  +E    +E +  SR+ +
Sbjct: 1670 RTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEI 1729

Query: 1271 HREQREYLDQLNALRREKQKLVEKI 1295
              + RE   +L  L  E  +L E++
Sbjct: 1730 FSQNRESEKRLKGLEAEVLRLQEEL 1754



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 209/887 (23%), Positives = 339/887 (38%), Gaps = 118/887 (13%)

Query: 131  EAVEQLEGVLRLLLGAS-VQCEHRELFIRHIQGLSLEVQSELA---AAIQEVTQPGAGVV 186
            E +E L G L   L ++  Q E R    + +  L   ++ E     AA+QE+ Q     +
Sbjct: 1204 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL 1263

Query: 187  LALS--------GPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLC 238
              L+        G    E     LE     L   LS L   R  G QR   L L+ + + 
Sbjct: 1264 GELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQ 1323

Query: 239  LRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRR- 297
             R     RA AE      A +L  A+A+L  +   L E     +    E+   EA++   
Sbjct: 1324 GRAGDGERARAEA-----AEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDA 1378

Query: 298  ---LRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEEL---RRCRERLQAAEA--- 348
               L++E +A      R      EA  LRE+      L+EE     R    LQ A+A   
Sbjct: 1379 QELLQEETRAKLALGSRVRAMEAEAAGLREQ------LEEEAAARERAGRELQTAQAQLS 1432

Query: 349  -YKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDS 407
             ++ + EEE   +G LEA         E AR R AR  E       L  RL E    +D 
Sbjct: 1433 EWRRRQEEE---AGALEAG--------EEARRRAAREAEA------LTQRLAEKTETVDR 1475

Query: 408  LRHQVDQLAEE--NVELELELQRSLEPPPGSPG---EAPLAGAAPSLQDEVREAEAGRLR 462
            L     +L +E  +  ++LE QR L           +  LA    ++   V E E     
Sbjct: 1476 LERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAE 1535

Query: 463  TLERENRELRGLLQVLQGQPGGQHPLLEAPRE-----DPVLPVLEEAPQTPVAFDHSPQG 517
              ERE R L  L + L+ +   +  L    R      + +L   ++  ++    + + + 
Sbjct: 1536 GREREARAL-SLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1594

Query: 518  LVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQ 577
              Q A D   Q  +L    L +  +A         +   + E  LQ      +A +   +
Sbjct: 1595 AEQAANDLRAQVTELEDE-LTAAEDAKLRLEVTVQALKTQHERDLQGR---DEAGEERRR 1650

Query: 578  ESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGEL--- 634
            +    +   E      R+    + A+    +G   +++A     G+  G+E    +L   
Sbjct: 1651 QLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQ--GKEEAVKQLRKM 1708

Query: 635  ---VPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVR 691
               + E W   +E  E +    E  S Q  E E   +GL+     AE     + L  + R
Sbjct: 1709 QAQMKELW---REVEETRTSREEIFS-QNRESEKRLKGLE-----AEVLRLQEELAASDR 1759

Query: 692  DPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQ 751
                Q  Q + E A EV            A+G   + A+ EE  QL  +   L +ELE +
Sbjct: 1760 ARR-QAQQDRDEMADEV------------ANGNLSKAAILEEKRQLEGRLGQLEEELEEE 1806

Query: 752  ARKLEAQNTEAARLSKELAQ-ARRAEAEAHREAEAQAWEQARLREAVEAAGQ--ELESAS 808
                E  N    +L  ++        AE    A+A++  Q   R+  E  G+  E ++ +
Sbjct: 1807 QSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGA 1866

Query: 809  QERE-----ALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERE 863
            + R      AL   LA A  +  Q  RE          AE+R+       ++ + + E E
Sbjct: 1867 RARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRL-------KEVVLQVEEE 1919

Query: 864  RREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRL 923
            RR  + L+ +LEK  +R K+L  +LE  + E  +A   R+   RE E   +  + + +  
Sbjct: 1920 RRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNR-- 1977

Query: 924  EAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEP 970
              E+           +   TR ++   ++F+L +G A     + A+P
Sbjct: 1978 --EVTTLRNRLRRGPLTFTTRTVR---QVFRLEEGVASDEEAEEAQP 2019



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 62/247 (25%), Positives = 109/247 (44%), Gaps = 33/247 (13%)

Query: 1079 KALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRE---LQGRHEQLQAQRASVEAQEV 1135
            K L Q+ R+ E     L  R ++L+      + + RE   LQGR  QL+ +RA +  Q  
Sbjct: 900  KPLLQVTRQDEV----LQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQ-- 953

Query: 1136 ALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLAR 1195
             L AE E L  +    RG      RL +     +++++EL    GE +    +++    R
Sbjct: 954  -LRAEAE-LCAEAEETRG------RLAARKQELELVVSELEARVGEEEECSRQMQTEKKR 1005

Query: 1196 LELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRE 1255
            L+    +LE   +    + Q+L L         ++ T+ +  + EE+  LL +  +   +
Sbjct: 1006 LQQHIQELEAHLEAEEGARQKLQLE--------KVTTEAKMKKFEEDLLLLEDQNSKLSK 1057

Query: 1256 NRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRTKKGSW 1315
             R+LLE  L        E+ E +  LN LR + +  +  + D+ R        + +KG  
Sbjct: 1058 ERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLR--------KEEKGRQ 1109

Query: 1316 LADKVKR 1322
              +K+KR
Sbjct: 1110 ELEKLKR 1116


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score =  153 bits (386), Expect = 1e-36
 Identities = 388/1529 (25%), Positives = 586/1529 (38%), Gaps = 250/1529 (16%)

Query: 106  QEELQLLI--LSPPPDLQTLGFDPLSEEAV------EQLEGVLRLLLGASVQCEHRELFI 157
            QEE QLL   LS   DL         E A+      E+LE  LRL  G     E R L +
Sbjct: 80   QEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGL-V 138

Query: 158  RHIQGLSLEVQSELAA------AIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMG 211
            R    L  ++Q E A+      A QE  Q  A +V  L G          L+   R    
Sbjct: 139  RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKI--------LQYKKRCSEL 190

Query: 212  TLSKLARERDLGAQRLAELL----LEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQL 267
                L R  +L  QRL +      LE   + L  E    A     +  L  QL  A +  
Sbjct: 191  EQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSAN 250

Query: 268  RRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQAL--SGQAKRAELYRE-------- 317
            + L +++ +        + E++  EA  RR  +   A   +  ++   L+R+        
Sbjct: 251  QALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLV 310

Query: 318  -EAEALRER-----AGRLPR-----------LQEELRRCRERLQAAEAYKSQLE---EER 357
             E +   ER      G L R           L   LR    R +AA   ++ L+   EE+
Sbjct: 311  SEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQ 370

Query: 358  VLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAE 417
            +   VL   K L ++Q+++  ++ A L     E  L   RL + + E D +   + +  E
Sbjct: 371  LRDKVLR-EKDLAQQQMQSDLDK-ADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLE 428

Query: 418  ENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAE--AGRLRTLERENRELRGLL 475
                L L+ Q +LE   G   +  L   A ++  +       +G  RT +  N  LRGL 
Sbjct: 429  ALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGL- 487

Query: 476  QVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKA---RDGGPQALDL 532
                    GQ       R  P          +P   D S   L+  A   R    Q +  
Sbjct: 488  -------SGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRG 540

Query: 533  APPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEK- 591
               A   +L    +     +S+ +  E  LQ        +  + +++   V+   S  + 
Sbjct: 541  RYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANEL 600

Query: 592  -AGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGR------EAPQGELVPEAWGLRQE 644
             +  +S+L     VA  Q    + +  +L   + E R      E  Q + V +   +R+E
Sbjct: 601  LSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRE 660

Query: 645  GPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE- 703
                     E S  QLE+ EG    L  A    E RE   R     RD    +  + +E 
Sbjct: 661  --------LERSHRQLEQLEGKRSVL--AKELVEVREALSRAT-LQRDMLQAEKAEVAEA 709

Query: 704  ------GALEVQVWEGPIPGE--SLASGVAEQEALREE-----------VAQLRRKAEAL 744
                  G +E+++    +  E  SL   +++  AL E            VAQL  +  AL
Sbjct: 710  LTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSAL 769

Query: 745  GD-----ELEAQARKLEAQNTEAARLSKELA---------------QARRAEAEAHREAE 784
                   E EA   + E +  E  RL +E+A               +A   +    R   
Sbjct: 770  QGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHER 829

Query: 785  AQAWEQ-ARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAE 843
            +Q  EQ A+L   +    QELE A +E +  VEAL  A RE+    +E + L  Q  AAE
Sbjct: 830  SQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAE 889

Query: 844  ERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQ 903
                    EGR   EEA R R EKEAL+  L        E+  +L  L+   EQ   E Q
Sbjct: 890  R-------EGRTLSEEATRLRLEKEALEGSLF-------EVQRQLAQLEARREQLEAEGQ 935

Query: 904  EFLREKESQHQRYQGLEQRLEAELQAAATSKE-----------EALMELKTRALQLEEEL 952
              L  KE+      GL Q++ A  + A+  KE           EA   L+ +    EE+L
Sbjct: 936  ALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL 995

Query: 953  FQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQ 1012
             +L++       +  AE   +++Q  R  E E   A L AEK  L  ++  L+      Q
Sbjct: 996  QRLQREKEAAWRELEAERAQLQSQLQR--EQEELLARLEAEKEELSEEIAALQ------Q 1047

Query: 1013 GRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVL----EEEVRAARQSQEETR 1068
             R + LLL     Q+  S  ++EK+ L  +       L  +    E + R A+  QE+ R
Sbjct: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDR 1107

Query: 1069 GQQQAL---LRDHKAL--------AQLQRRQEAELEGL-------LVRHRDLKANMRALE 1110
                AL   LRD +A         AQ  RR + +   L       L    +L+  +R LE
Sbjct: 1108 STVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLE 1167

Query: 1111 LAHRELQGRHEQLQAQRASVEAQEVALLAERE-----RLMQDGHRQRGLEEELRRLQSEH 1165
             A   L  R E L+AQR   E+QE   +  +E     R + +G ++R   E LRR  +E 
Sbjct: 1168 DARDGL--RRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKER---EALRR-SNEE 1221

Query: 1166 DRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLT 1225
             R+ +  AE  R   +L  E  E +  LA LE  R  +  ++ +LR   Q+++ S     
Sbjct: 1222 LRSAVKKAESERISLKLANEDKEQK--LALLEEARTAVGKEAGELRTGLQEVERSRLEAR 1279

Query: 1226 TQCELLTQLRSAQEEENRQL---LAEVQ--------ALSRENRELL---------ERSLE 1265
             + + L +     + EN +L   LAE+Q        A     RE L         E SLE
Sbjct: 1280 RELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLE 1339

Query: 1266 -SRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRT-----KKGSWLADK 1319
              R  L   QR+  +Q    R  +++L+   +++ R  E   L        K  +  A+ 
Sbjct: 1340 VMRQELQVAQRKLQEQEGEFRTRERRLLGS-LEEARGTEKQQLDHARGLELKLEAARAEA 1398

Query: 1320 VKRLMRPRREGGPPGGL-----RLGADGAGSTESLGGPPETELPEGREADGTGSPSPAPM 1374
             +  +R     G   GL     R+      +   LGG   + L  G       SP+P P+
Sbjct: 1399 AELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGG-LRSALRRGLGLGRAPSPAPRPV 1457

Query: 1375 RRAQSSLCLRDETLAGGQRRKLSSRFPVGRSSESFSPGDTPRQRFRQRHPGPLGAPVSHS 1434
              + +      +  A G    L+S      S+   SPG  P        PGP  +P S  
Sbjct: 1458 PGSPAR-----DAPAEGSGEGLNS-----PSTLECSPGSQPPS------PGPATSPASPD 1501

Query: 1435 KGPGVGWENSAETLQEHETDANREGPEVQ 1463
              P        E LQE  + A RE  E++
Sbjct: 1502 LDPEAVRGALREFLQELRS-AQRERDELR 1529



 Score =  151 bits (382), Expect = 4e-36
 Identities = 317/1317 (24%), Positives = 520/1317 (39%), Gaps = 228/1317 (17%)

Query: 129  SEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGVVLA 188
            S   +EQLEG   +L  A    E RE   R      + +Q+E A   + +T+  AG V  
Sbjct: 664  SHRQLEQLEGKRSVL--AKELVEVREALSRATLQRDM-LQAEKAEVAEALTKAEAGRVEL 720

Query: 189  LSGPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAP 248
                   EL+  +L     SL  +LSKL+   +  AQ   +L              +R  
Sbjct: 721  -------ELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDL--------------NRLV 759

Query: 249  AEGPSHHLALQLANAKAQLRRL--RQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALS 306
            A+      ALQ    +A+      R+E E   EL L+ +   QGLE  +R   Q  +AL 
Sbjct: 760  AQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALE 819

Query: 307  GQA-----KRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAE-------------- 347
             Q      +R++L  + A+  R+ +GR   L++  R  + +++A E              
Sbjct: 820  QQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHA 879

Query: 348  -------------------AYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQ 388
                               A + +LE+E +   + E  + L   QLEA RE+     E +
Sbjct: 880  GLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLA--QLEARREQL----EAE 933

Query: 389  RENLLLRTRLGEAHAELDSLRHQV-----------DQLAEENVELELELQRSLEPPPGSP 437
             + LLL         EL  LR Q+           + +A++ V+ E E Q SL     + 
Sbjct: 934  GQALLLAKET--LTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAH 991

Query: 438  GEAPLAGAAPSLQDEVREAEAGRLRT---LERENRELRGLLQVLQGQPGGQHPLLEAPRE 494
             E  L       +   RE EA R +    L+RE  EL   L+  + +   +   L+  R+
Sbjct: 992  -EEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERD 1050

Query: 495  DPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSD 554
            + +L + E   Q  ++   S +  + +   G   +L      +   +E      Q+    
Sbjct: 1051 EGLL-LAESEKQQALSLKESEKTALSEKLMGTRHSL----ATISLEMERQKRDAQSRQEQ 1105

Query: 555  PQEAESPLQAAAMDPQASDWSPQESGSPVETQESP--EKAGRRSSLQSPASVAPPQGPGT 612
             +   + L +   D +A     +E  +    QE    ++  R    Q  + +   +   T
Sbjct: 1106 DRSTVNALTSELRDLRAQ----REEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRT 1161

Query: 613  KIQA---------PQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQ 663
            +++           +LL  + + RE+ +G  V      RQE  E +    E +  + E  
Sbjct: 1162 QLRLLEDARDGLRRELLEAQRKLRESQEGREVQ-----RQEAGELRRSLGEGAK-EREAL 1215

Query: 664  EGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASG 723
               N+ L  A  +AE+     +L       A +  +QK     E +   G   GE L +G
Sbjct: 1216 RRSNEELRSAVKKAESERISLKL-------ANEDKEQKLALLEEARTAVGKEAGE-LRTG 1267

Query: 724  VAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNT----EAARLSKELAQARRAEAEA 779
            + E E  R E    RR+ +    EL  Q + L+++NT    E A L   LA   RAE E+
Sbjct: 1268 LQEVERSRLEA---RRELQ----ELRRQMKMLDSENTRLGRELAELQGRLALGERAEKES 1320

Query: 780  HREAEAQAWEQARLREAVEAAGQELESA------------SQEREALVEALAAAGRERRQ 827
             RE         +   ++E   QEL+ A            ++ER  L     A G E++Q
Sbjct: 1321 RRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQ 1380

Query: 828  WER-EGSRLR---AQSEAAEERMQVLESEGRQHLEEAER-----ERREKEALQAELEKAV 878
             +   G  L+   A++EAAE  +++  +EGR    EAE      +RR  EA    L  A+
Sbjct: 1381 LDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSAL 1440

Query: 879  VRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEAL 938
             RG  LG       R +  +           E  +     LE    ++  +   +   A 
Sbjct: 1441 RRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSP-STLECSPGSQPPSPGPATSPAS 1499

Query: 939  MELKTRALQ--LEEELFQLRQGPAGLGPKKRAEPQL-VETQNVRLIEVERSNAMLVAEKA 995
             +L   A++  L E L +LR        ++R E +      N +L E+E       +   
Sbjct: 1500 PDLDPEAVRGALREFLQELRSAQ-----RERDELRTQTSALNRQLAEMEAERDSATSRAR 1554

Query: 996  ALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEE 1055
             LQ  +   E    S+ GR   +  +    +E   R + E+     Q   L R L+  E 
Sbjct: 1555 QLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATES 1614

Query: 1056 EVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRA--LELAH 1113
            E+RA+++   + +  +  L  D + L ++    E+    L ++ R L+  ++   L L+ 
Sbjct: 1615 ELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSD 1674

Query: 1114 RE-----LQGRHEQLQAQRASVEAQE-------------VALLAERERLMQDGHRQRGLE 1155
            RE     LQ R + LQ Q A  E +              +A + E E  ++D  + RGL 
Sbjct: 1675 REAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRD--KVRGLT 1732

Query: 1156 EELRRLQS-------------------EHDR---------AQMLLAELSRERGELQGERG 1187
            E L +  +                   EHDR         A+  L+E  ++   L  +  
Sbjct: 1733 EALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQ 1792

Query: 1188 ELRGRLARLELERAQLEMQSQQLRE-SNQQLDLSACRLTTQCELLTQLRSAQEE--ENRQ 1244
             LRG +A LEL+R + E Q QQLRE   Q+ +  A  L T  +L  + R  QE     ++
Sbjct: 1793 TLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQR 1852

Query: 1245 LLAEVQALSRE----------NRELLERSLESRDHLHREQREYLDQLNALRREKQKL 1291
             LA+++A  RE          +R  L R+L   D + RE+    +    L  EK +L
Sbjct: 1853 ALAQLEAEKREVERSALRLEKDRVALRRTL---DKVEREKLRSHEDTVRLSAEKGRL 1906



 Score =  134 bits (338), Expect = 5e-31
 Identities = 299/1287 (23%), Positives = 512/1287 (39%), Gaps = 162/1287 (12%)

Query: 121  QTLGFDPLSEEAVEQLEGV--LRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQ-- 176
            Q L  D ++++  E+LE +  LRL   A+++ E  E   + ++ L+  V S+  + +Q  
Sbjct: 412  QNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLS 471

Query: 177  ---EVTQPGAGVVLALSGP----DPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAE 229
                      G +  LSG      P   +P       R      S      D     L  
Sbjct: 472  GSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACS------DSSTLALIH 525

Query: 230  LLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQ 289
              L +  L ++        ++     L  QL++++++ R L ++L+   +    +    +
Sbjct: 526  SALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHE 585

Query: 290  GLEAEIRRLRQEAQALSGQ----AKRAELYREEAEALRERAGRLPRLQEELRRCRERLQA 345
              + E++RLR   + LS +    A   ++ +++AE LR+   +L   QEELRR R+RL+ 
Sbjct: 586  DAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLE- 644

Query: 346  AEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAEL 405
             E  +  +++   +   LE S   LE QLE  R   A+      E + +R  L  A  + 
Sbjct: 645  -EEQEDAVQDGARVRRELERSHRQLE-QLEGKRSVLAK------ELVEVREALSRATLQR 696

Query: 406  DSLRHQVDQLAEENVELE---LELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLR 462
            D L+ +  ++AE   + E   +EL+ S+           L     SLQD + +  A    
Sbjct: 697  DMLQAEKAEVAEALTKAEAGRVELELSM---------TKLRAEEASLQDSLSKLSALN-E 746

Query: 463  TLERENRELRGLLQVLQGQPGG-QHPLLEAPREDPVLPVLEEA-PQTPVAFDHSPQGLVQ 520
            +L ++  +L  L+  L+ +    Q    +A +E  V    +E   +  +  + + QGL  
Sbjct: 747  SLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEG 806

Query: 521  KAR--DGGPQALDLAPPAL----DSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDW 574
              R  +   +AL+   P L      + E  A+  +      QE E   + A    +A + 
Sbjct: 807  SLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALER 866

Query: 575  SPQESGSPVETQE-------SPEKAGRRSSLQSPASVAPPQG-PGTKIQAPQLLGGETEG 626
            + +E  +  +          + E+ GR  S ++       +   G+  +  + L      
Sbjct: 867  AAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEAR 926

Query: 627  REAPQGE----------LVPEAWGLRQE--GPEHKPGPSEPSSVQLEEQEGPNQGLDLAT 674
            RE  + E          L  E  GLRQ+    + K    +    Q   Q        L  
Sbjct: 927  REQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLRE 986

Query: 675  GQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEV 734
             +A   E  QRL+   ++ AW++ + +    L+ Q+       E LA   AE+E L EE+
Sbjct: 987  QRAAHEEDLQRLQRE-KEAAWRELEAE-RAQLQSQLQREQ--EELLARLEAEKEELSEEI 1042

Query: 735  AQLRRKAEA---LGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWE-- 789
            A L+++ +    L +  + QA  L  + +E   LS++L   R + A    E E Q  +  
Sbjct: 1043 AALQQERDEGLLLAESEKQQA--LSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQ 1100

Query: 790  --QARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEA----AE 843
              Q + R  V A   EL     +RE   EA AA  +E R+ + +   L  Q ++    AE
Sbjct: 1101 SRQEQDRSTVNALTSELRDLRAQRE---EAAAAHAQEVRRLQEQARDLGKQRDSCLREAE 1157

Query: 844  E---RMQVLESEG---RQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQ 897
            E   ++++LE      R+ L EA+R+ RE +      E   V+ +E G     L+R L +
Sbjct: 1158 ELRTQLRLLEDARDGLRRELLEAQRKLRESQ------EGREVQRQEAG----ELRRSLGE 1207

Query: 898  AALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQ 957
             A ER+   R  E      +  E      L+ A   KE+ L  L+     + +E  +LR 
Sbjct: 1208 GAKEREALRRSNEELRSAVKKAESE-RISLKLANEDKEQKLALLEEARTAVGKEAGELRT 1266

Query: 958  GPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQE 1017
            G       +  E   +E +   L E+ R   ML +E   L  +L  L+G+L   +   +E
Sbjct: 1267 G------LQEVERSRLEARR-ELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKE 1319

Query: 1018 LLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQ----SQEETRGQQQA 1073
               ++   ++   + +A   V+  + Q   RKL+  E E R   +    S EE RG ++ 
Sbjct: 1320 SRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQ 1379

Query: 1074 LLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQ 1133
             L DH       R  E +LE       +L   + A E   + L+    +++ QR + EAQ
Sbjct: 1380 QL-DHA------RGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQ 1432

Query: 1134 EVALLAERERLMQDGHRQ---------------------RGLEEELRRLQSEHDRAQMLL 1172
               L +   R +  G                         GL        S   +     
Sbjct: 1433 LGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPG 1492

Query: 1173 AELSRERGELQGE--RGELRGRLARL---ELERAQLEMQSQQLRESNQQLDLSACRLTTQ 1227
               S    +L  E  RG LR  L  L   + ER +L  Q+  L     +++      T++
Sbjct: 1493 PATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSR 1552

Query: 1228 CELLTQLRSAQEEENRQL---LAEVQALSRENRELLERSLESRDHLHREQREYLDQLNAL 1284
               L +  +  EE  R +   L+ VQA      E + RS        RE+R  LDQ+  L
Sbjct: 1553 ARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRS-------ERERRATLDQVATL 1605

Query: 1285 RREKQKLVEKIMDQYRVLEPVPLPRTK 1311
             R  Q    ++      +  +    TK
Sbjct: 1606 ERSLQATESELRASQEKISKMKANETK 1632



 Score =  134 bits (337), Expect = 6e-31
 Identities = 265/1053 (25%), Positives = 418/1053 (39%), Gaps = 124/1053 (11%)

Query: 119  DLQTLGFDPLSEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEV 178
            DLQ L  +   E A  +LE   R  L + +Q E  EL  R ++    E+  E+AA  QE 
Sbjct: 994  DLQRLQRE--KEAAWRELEAE-RAQLQSQLQREQEELLAR-LEAEKEELSEEIAALQQER 1049

Query: 179  TQPGAGVVLALSGPDPG-ELAPAELEMLSRSLMGTLSKLA--------RERDLGAQ---- 225
             +   G++LA S       L  +E   LS  LMGT   LA        ++RD  ++    
Sbjct: 1050 DE---GLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQD 1106

Query: 226  RLAELLLEREPLCLRPEAPSRAPAEGPS----HHLALQLANAKAQLRRLRQELEEKAELL 281
            R     L  E   LR +    A A           A  L   +    R  +EL  +  LL
Sbjct: 1107 RSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLL 1166

Query: 282  LDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRE 341
             D++  ++    E +R  +E+Q      +  E+ R+EA  LR   G   + +E LRR  E
Sbjct: 1167 EDARDGLRRELLEAQRKLRESQ------EGREVQRQEAGELRRSLGEGAKEREALRRSNE 1220

Query: 342  RLQAAEAYKSQLEEERVLSGVLEASK----ALLEEQLEAARERCARLHETQRENLLLRTR 397
             L++A     + E ER+   +    K    ALLEE   A  +    L    +E  + R+R
Sbjct: 1221 ELRSAV---KKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQE--VERSR 1275

Query: 398  LGEAHAELDSLRHQVDQLAEENVELELEL-QRSLEPPPGSPGEAPLAGAAPSLQDEVREA 456
            L EA  EL  LR Q+  L  EN  L  EL +       G   E         L+  + + 
Sbjct: 1276 L-EARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKG 1334

Query: 457  EAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVA-FDHSP 515
            EA    +LE   +EL+   + LQ Q G         RE  +L  LEEA  T     DH+ 
Sbjct: 1335 EA----SLEVMRQELQVAQRKLQEQEGEFRT-----RERRLLGSLEEARGTEKQQLDHA- 1384

Query: 516  QGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDW- 574
            +GL  K      +A +L        L  SA   +A   + + A   +Q  A + Q     
Sbjct: 1385 RGLELKLEAARAEAAELG-------LRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLR 1437

Query: 575  SPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQG-- 632
            S    G  +    SP     R    SPA  AP +G G  + +P  L      +    G  
Sbjct: 1438 SALRRGLGLGRAPSPAP---RPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPA 1494

Query: 633  ------ELVPEA--WGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQ 684
                  +L PEA    LR+   E +    E   ++ +      Q  ++   +  A    +
Sbjct: 1495 TSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRAR 1554

Query: 685  RLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEAL 744
            +L+  V +   ++ ++  +G L     E  +  ES+     E+ A  ++VA L R  +A 
Sbjct: 1555 QLQKAVAES--EEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQAT 1612

Query: 745  GDELEAQARKLEAQNTEAARLS------KEL---AQARRAEAEAHREAEAQAWEQARL-- 793
              EL A   K+        +L       KE+   +++R  + E  R +     +++RL  
Sbjct: 1613 ESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGL 1672

Query: 794  --REAVEAAGQELESASQEREALVEALAAA---------GRERRQWEREGS---RLRAQS 839
              REA   A Q+   + Q + A  E  A           G   +  E EG+   ++R  +
Sbjct: 1673 SDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLT 1732

Query: 840  EAAEERMQVLES--EGRQHLEEA----ERERR----EKEALQAELEKAVVRGKELGARLE 889
            EA  +    L S  +   HL++A    E +R+      +A +  L +A  +   LG +++
Sbjct: 1733 EALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQ 1792

Query: 890  HLQRELEQAALERQEF------LREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKT 943
             L+ E+    L+R E       LRE   Q Q  +        +LQ      +E L  L+ 
Sbjct: 1793 TLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQR 1852

Query: 944  RALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQH 1003
               QLE E  ++ +    L   + A  + ++      +        L AEK  L   L  
Sbjct: 1853 ALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTG 1912

Query: 1004 LEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQS 1063
             E +L   Q + Q+L  Q    ++  S  Q E   ++ Q Q+L      L++EV   R +
Sbjct: 1913 AELELAEAQRQIQQLEAQVVVLEQSHSPAQLE---VDAQQQQLE-----LQQEVERLRSA 1964

Query: 1064 QEETRGQQQALLRDHKALAQLQRRQEAELEGLL 1096
            Q +T    +A  R H+   +    Q + L+G L
Sbjct: 1965 QAQTERTLEARERAHRQRVRGLEEQVSTLKGQL 1997



 Score =  134 bits (336), Expect = 8e-31
 Identities = 301/1273 (23%), Positives = 520/1273 (40%), Gaps = 183/1273 (14%)

Query: 130  EEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGVVLAL 189
            E A + LEG LR+   A    E +   +RH +    ++Q +LA   ++           L
Sbjct: 798  EVARQGLEGSLRVAEQAQEALEQQLPTLRHERS---QLQEQLAQLSRQ-----------L 843

Query: 190  SGPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLL-----EREPLCLRPEAP 244
            SG +  EL  A  E  ++  +  L + ARE++  A+  A L +     ERE   L  EA 
Sbjct: 844  SGREQ-ELEQARRE--AQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEAT 900

Query: 245  ----SRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRR--- 297
                 +   EG    +  QLA    QL   R++LE + + LL ++  + G  A +R+   
Sbjct: 901  RLRLEKEALEGSLFEVQRQLA----QLEARREQLEAEGQALLLAKETLTGELAGLRQQII 956

Query: 298  LRQEAQALSGQAKRAELYREEAEA---LRERAGR----LPRLQEELRRCRERLQAAEAY- 349
              QE  +L  +    +L + E EA   LRE+       L RLQ E       L+A  A  
Sbjct: 957  ATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQL 1016

Query: 350  KSQLE-EERVLSGVLEASKALLEEQL--------------EAARERCARLHETQRENL-- 392
            +SQL+ E+  L   LEA K  L E++              E+ +++   L E+++  L  
Sbjct: 1017 QSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSE 1076

Query: 393  -LLRTR--LGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAP-- 447
             L+ TR  L     E++  +       E++      L   L        EA  A A    
Sbjct: 1077 KLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVR 1136

Query: 448  SLQDEVREAEAGRLRTLERENRELRGLLQVLQ-GQPGGQHPLLEAPREDPVLPVLEEAPQ 506
             LQ++ R+    R   L RE  ELR  L++L+  + G +  LLEA R+      L E+ Q
Sbjct: 1137 RLQEQARDLGKQRDSCL-REAEELRTQLRLLEDARDGLRRELLEAQRK------LRES-Q 1188

Query: 507  TPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAA 566
                      G ++++   G +  +    + + +  A  +      S     E   Q  A
Sbjct: 1189 EGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLA 1248

Query: 567  MDPQASDWSPQESG---SPVETQESPEKAGRRSSLQSPASVAPPQGPGTKI--QAPQLLG 621
            +  +A     +E+G   + ++  E      RR   +    +       T++  +  +L G
Sbjct: 1249 LLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQG 1308

Query: 622  GETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEARE 681
                G  A + E   E  GLRQ   + +      +S+++  QE       L   + E R 
Sbjct: 1309 RLALGERAEK-ESRRETLGLRQRLLKGE------ASLEVMRQELQVAQRKLQEQEGEFRT 1361

Query: 682  HDQRLEGTVRDPAWQKPQQKS-----EGALEVQVWEGPIPGESLASGVAEQEALREEVAQ 736
             ++RL G++ +    + QQ       E  LE    E    G  L++     + L  E+A+
Sbjct: 1362 RERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELAR 1421

Query: 737  L---RRKAEALGDELEAQARKLEAQNTEAARLSKEL--AQARRAEAEAHREA-EAQAWEQ 790
            +   RR AEA    L +  R+        +   + +  + AR A AE   E   + +  +
Sbjct: 1422 VEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLE 1481

Query: 791  ARLREAVEAAGQELESASQER--EALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQV 848
                    + G     AS +   EA+  AL    +E R  +RE   LR Q+ A   ++  
Sbjct: 1482 CSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAE 1541

Query: 849  LESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQREL--EQAALERQEFL 906
            +E+E     + A    R+ +   AE E+A    + +  RL  +Q EL  ++ ++ R E  
Sbjct: 1542 MEAER----DSATSRARQLQKAVAESEEA---RRSVDGRLSGVQAELALQEESVRRSE-- 1592

Query: 907  REKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKK 966
            RE+ +   +   LE+ L+A  ++   + +E + ++K    +LE             G K+
Sbjct: 1593 RERRATLDQVATLERSLQAT-ESELRASQEKISKMKANETKLE-------------GDKR 1638

Query: 967  RAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQ 1026
            R + ++++    R +++E        ++ +L+G+LQ     L   + +AQ L  +    Q
Sbjct: 1639 RLK-EVLDASESRTVKLE-------LQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQ 1690

Query: 1027 EHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKAL----- 1081
               +  + +   L++  + L+  L  +EE   A R   ++ RG  +AL +   +L     
Sbjct: 1691 RQVADSEVKAGTLQLTVERLNGALAKVEESEGALR---DKVRGLTEALAQSSASLNSTRD 1747

Query: 1082 --AQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQR---ASVEAQEVA 1136
                LQ+   A      V    L A  +AL  A ++     EQ+Q  R   A +E Q V 
Sbjct: 1748 KNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVE 1807

Query: 1137 LLAE----RERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGR 1192
               +    RE L Q    +      +++LQ E    Q  L  L R   +L+ E+ E+   
Sbjct: 1808 AEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERS 1867

Query: 1193 LARLELERAQL-----EMQSQQLRESNQQLDLSA-----CRLTTQCEL------------ 1230
              RLE +R  L     +++ ++LR     + LSA      R  T  EL            
Sbjct: 1868 ALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQL 1927

Query: 1231 ------------LTQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQ-REY 1277
                          QL    +++  +L  EV+ L R  +   ER+LE+R+  HR++ R  
Sbjct: 1928 EAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERL-RSAQAQTERTLEARERAHRQRVRGL 1986

Query: 1278 LDQLNALRREKQK 1290
             +Q++ L+ + Q+
Sbjct: 1987 EEQVSTLKGQLQQ 1999



 Score = 87.8 bits (216), Expect = 7e-17
 Identities = 162/680 (23%), Positives = 266/680 (39%), Gaps = 74/680 (10%)

Query: 644  EGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE 703
            E P   P     S + L+E+   NQ L     + E      R E       +    ++ E
Sbjct: 63   ESPVLLPATEMASLLSLQEE---NQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLE 119

Query: 704  GALEVQVWEGPI--PGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTE 761
             AL ++  E     P   +   V  +  L+EE A  RRK +A  +  + QA+ ++    +
Sbjct: 120  QALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGK 179

Query: 762  AARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAA 821
              +  K  ++  +   E   E E Q        + +E+A   LE   Q   +L +  A  
Sbjct: 180  ILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAML 239

Query: 822  GRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERE-RREKEALQAELEKAVVR 880
               R Q ++ GS  +A SE   +      +  R+ LE  E   RRE+E+  A       R
Sbjct: 240  ---REQLDQAGSANQALSEDIRKVTNDW-TRCRKELEHREAAWRREEESFNAYFSNEHSR 295

Query: 881  GKELGARLEHLQRELEQAAL--ERQ------EFLREKESQHQRYQGLEQRLE-AELQAAA 931
               L  ++   +R + +  +  ER       E  R   +  +   GL   L  AE +A A
Sbjct: 296  LLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEA 355

Query: 932  TSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLV 991
              +++AL++      QLEE+L            K   E  L + Q    ++ +   A L 
Sbjct: 356  ALEKQALLQA-----QLEEQLRD----------KVLREKDLAQQQ----MQSDLDKADLS 396

Query: 992  AEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLE 1051
            A    L   ++ LE Q    + +  + L +   A E S RLQ + ++    G+ L + L 
Sbjct: 397  ARVTELGLAVKRLEKQ-NLEKDQVNKDLTEKLEALE-SLRLQEQAALETEDGEGLQQTLR 454

Query: 1052 VLEEEVRAARQSQEETRGQQQALLRDHKALAQL--QRRQEAELEGLLVRHRDLK------ 1103
             L + V +  +S  +  G ++     + +L  L  QR           R R  +      
Sbjct: 455  DLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPA 514

Query: 1104 -ANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQ 1162
             ++   L L H  L  R  Q+Q  R   EA +  L   R++L      +R LEE+L+RL+
Sbjct: 515  CSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLR 574

Query: 1163 SEHDRAQMLLAE--------------LSRERGEL-------QGERGELRGRLARLELERA 1201
             + D A     +              LSRE+  L       Q +  ELR    +L+  + 
Sbjct: 575  DKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQE 634

Query: 1202 QLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLE 1261
            +L  Q  +L E  +       R+  + E  +  +  Q E  R +LA+      E RE L 
Sbjct: 635  ELRRQRDRLEEEQEDAVQDGARVRRELE-RSHRQLEQLEGKRSVLAKELV---EVREALS 690

Query: 1262 RSLESRDHLHREQREYLDQL 1281
            R+   RD L  E+ E  + L
Sbjct: 691  RATLQRDMLQAEKAEVAEAL 710


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score =  148 bits (373), Expect = 4e-35
 Identities = 272/1160 (23%), Positives = 454/1160 (39%), Gaps = 155/1160 (13%)

Query: 196  ELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAP--SRAPAEGPS 253
            ELA    E+  R L G L+    +R    +    +  E+  L L+ +A   + A AE   
Sbjct: 897  ELAALRAEL--RGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERC 954

Query: 254  HHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAE 313
            H L       + +++ L + LE++ E+  D  A  + LE E   L+++   L     +AE
Sbjct: 955  HLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAE 1014

Query: 314  LYR-----------EEAEALRERAGRLPRLQEELRRCRERL------------------- 343
              +           EE  AL E   RL + ++ L+   ++                    
Sbjct: 1015 KEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKL 1074

Query: 344  ---QAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGE 400
               Q  E  +  LE+E+ L    E +K  LE  L+  +E  A   +  ++   L  +L +
Sbjct: 1075 RLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVA---DAAQDKQQLEEKLKK 1131

Query: 401  AHAELDSLRHQVD----------------QLAEENVELELELQRSLEPPPGSPGEAPLAG 444
              +EL  L  +V+                Q   E +E ELE +R+      +  E   A 
Sbjct: 1132 KDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAAR----ARVEKQRAE 1187

Query: 445  AAPSLQ------DEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVL 498
            AA  L+      +E   A AG+     +   EL  L + L+         + A R     
Sbjct: 1188 AARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAE 1247

Query: 499  PVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQ-APDSDPQE 557
               E   Q   +     Q L ++  +   +  DLA   ++++  A A   +     + Q 
Sbjct: 1248 GAAELGEQVD-SLQRVRQKLEKEKSELRMEVDDLA-ANVETLTRAKASAEKLCRTYEDQL 1305

Query: 558  AESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAP 617
            +E+ ++   +  Q +D S Q      E+ E       +  L S  S    +G     Q+ 
Sbjct: 1306 SEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLS----RGKALAAQSL 1361

Query: 618  QLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQA 677
            + L  + E     +  L      LR +    +    E +  Q E Q        L+   A
Sbjct: 1362 EELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQR------LLSKANA 1415

Query: 678  EAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQL 737
            E  +   + E        +  + K + AL +Q  E     E + +  A+  +L +   +L
Sbjct: 1416 EVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAE-----EGVEAANAKCSSLEKAKLRL 1470

Query: 738  RRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAV 797
            + ++E +  ELE       A + +   L + L + RR E E  RE EA   E   L    
Sbjct: 1471 QTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGL---- 1526

Query: 798  EAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHL 857
               G EL       E  +EAL    RE +  + E S L  Q   + + +Q LE + ++ L
Sbjct: 1527 ---GTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELE-KTKKAL 1582

Query: 858  EEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQ----H 913
            E       EK  +QA LE+A    +    +   +Q EL Q   E    L EK+ +     
Sbjct: 1583 E------GEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLR 1636

Query: 914  QRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQL----RQGPAGLGPKKRAE 969
            + +Q   + L+A L A   ++ EAL   K     L +   QL    RQ        +  +
Sbjct: 1637 RNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQ 1696

Query: 970  PQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSL-----QGRAQELLLQSQ- 1023
             QL E Q  R  E +R  A L  +  AL+ +   L  +L  L     QG     L + + 
Sbjct: 1697 AQLKEEQAGR-DEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQEL 1755

Query: 1024 -RAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALA 1082
              A E  + L ++ + L  Q ++L   L  L  EV  A Q + E   + +  + D   +A
Sbjct: 1756 LEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMA 1815

Query: 1083 -QLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAER 1141
             +L++ Q+            L+   + LE   RELQ R E         EA++ AL   +
Sbjct: 1816 EELKKEQDTSAH--------LERMKKTLEQTVRELQARLE---------EAEQAALRGGK 1858

Query: 1142 ERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLE--LE 1199
            +++ +   + R LE EL   Q +H  A   + +  R   EL  +  E R  LAR++  ++
Sbjct: 1859 KQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVD 1918

Query: 1200 RAQLEMQS--QQLRESNQQLDLSACRLTTQCELLTQLRSAQEE----ENRQLLAEVQALS 1253
            + Q +++S  +Q  E+ QQ + +          L + R AQ E    E R  +AE QA  
Sbjct: 1919 KLQSKVKSYKRQFEEAEQQANTN----------LAKYRKAQHELDDAEERADMAETQA-- 1966

Query: 1254 RENRELLERSLESRDHLHRE 1273
                +L  R+ ++    H+E
Sbjct: 1967 ---NKLRARTRDALGPKHKE 1983



 Score =  107 bits (267), Expect = 8e-23
 Identities = 252/1077 (23%), Positives = 419/1077 (38%), Gaps = 147/1077 (13%)

Query: 329  LPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQ 388
            L  L+ ELR  R  L AAEA + +LEE  V    +   K  L  QL+A ++  A   E  
Sbjct: 898  LAALRAELRGLRGALAAAEAKRQELEETHVS---ITQEKNDLALQLQAEQDNLADAEE-- 952

Query: 389  RENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPS 448
            R +LL+++++         L  +V +L+E  +E E E+             A LA     
Sbjct: 953  RCHLLIKSKV--------QLEGKVKELSER-LEDEEEVN------------ADLAARRRK 991

Query: 449  LQDEVREAEAG------RLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLE 502
            L+DE  E +         L   E+E +     ++ L  +         A  ++ V  + +
Sbjct: 992  LEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEM--------AALDESVARLTK 1043

Query: 503  EAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSV---LEASAECPQAPDSDPQEAE 559
            E      A   +   L  +A +    AL  A   L+     LE S E  +    D + A+
Sbjct: 1044 EKKALQEAHQQALGDL--QAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAK 1101

Query: 560  SPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQL 619
              L+      Q S      + +  + Q+  EK  ++ S  S  S+        +++  QL
Sbjct: 1102 RKLEGDLKLTQES-----VADAAQDKQQLEEKLKKKDSELSQLSL--------RVEDEQL 1148

Query: 620  LGGETEGR----EAPQGELVPEAWGLRQEGPEHKPGPSEPS------SVQLEEQEGPNQG 669
            LG + + +    +A   EL  E    R      +   +E +      S +LEE  G + G
Sbjct: 1149 LGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAG 1208

Query: 670  ---------LDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESL 720
                      +L   + E  E   R E TV        ++++EGA E+        GE +
Sbjct: 1209 QREGCRKREAELGRLRRELEEAALRHEATVA----ALRRKQAEGAAEL--------GEQV 1256

Query: 721  ASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAH 780
             S    ++ L +E ++LR + + L   +E   R   +          +L++A+    E  
Sbjct: 1257 DSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQ 1316

Query: 781  REAEAQAWEQARLREAVEAAGQELESASQEREALV------EALAAAGRE--RRQWEREG 832
            R+    + ++ RL    +    EL    +E+E L+      +ALAA   E  RRQ E E 
Sbjct: 1317 RQLADASTQRGRL----QTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEES 1372

Query: 833  SRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQ 892
                A + A +      +    QH EEAE         QAEL++ + +     A +   +
Sbjct: 1373 KAKSALAHAVQALRHDCDLLREQHEEEAEA--------QAELQRLLSKAN---AEVAQWR 1421

Query: 893  RELEQAALERQEFLRE-KESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEE 951
             + E  A++R E L E K+    R Q  E+ +EA   A  +S E+A + L+T +  +  E
Sbjct: 1422 SKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAA-NAKCSSLEKAKLRLQTESEDVTLE 1480

Query: 952  LFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSL 1011
            L +     A L  K+R   + +E +  +  E++R       E   L  +L  L       
Sbjct: 1481 LERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEA 1540

Query: 1012 QGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQ 1071
                + L  +++  QE  S L  + S+     QEL +  + LE E    + + EE  G  
Sbjct: 1541 LEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGAL 1600

Query: 1072 QALLRDHKALA-QLQRRQ-EAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQR-A 1128
            +  L + K L  QL+  Q +AE++  L    +  AN+R      R  Q   E LQA   A
Sbjct: 1601 E--LEETKTLRIQLELSQVKAEVDRKLAEKDEECANLR------RNHQRAVESLQASLDA 1652

Query: 1129 SVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGE 1188
               A+  AL  +++        +  L    R+        +++ A+L  E+     E+  
Sbjct: 1653 ETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQ-- 1710

Query: 1189 LRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAE 1248
               RLA      A+L  Q+Q L      L      L    E   + R   E+E  +    
Sbjct: 1711 ---RLA------AELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATER 1761

Query: 1249 VQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVP-- 1306
            +  L  +N  LL +  +    L +   E  +     R  ++K  + I D   + E +   
Sbjct: 1762 LNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKE 1821

Query: 1307 ------LPRTKKGSWLADKVKRLMRPRREGGPPGGLRLGADGAGSTESLGGPPETEL 1357
                  L R KK     ++  R ++ R E      LR G       E+     E EL
Sbjct: 1822 QDTSAHLERMKK---TLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAEL 1875



 Score =  103 bits (257), Expect = 1e-21
 Identities = 258/1116 (23%), Positives = 428/1116 (38%), Gaps = 256/1116 (22%)

Query: 130  EEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGVVLAL 189
            E+ VE LE  L       +  E  +   R ++G     Q  +A A Q+  Q    +   L
Sbjct: 1077 EQQVEDLECSLEQEKKLRMDTERAK---RKLEGDLKLTQESVADAAQDKQQ----LEEKL 1129

Query: 190  SGPDPGELAPAELEMLSRSLMGT-LSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAP 248
               D  EL+   L +    L+G  + K  +E    A+ L E L          E  +RA 
Sbjct: 1130 KKKD-SELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEEL--------EAERAARAR 1180

Query: 249  AEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQ--ALS 306
             E        Q A A  +L  L + LEE        +   +  EAE+ RLR+E +  AL 
Sbjct: 1181 VEK-------QRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALR 1233

Query: 307  GQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEAS 366
             +A  A L R++AE     A  L    + L+R R++L+  E  + ++E + + + V   +
Sbjct: 1234 HEATVAALRRKQAEG----AAELGEQVDSLQRVRQKLE-KEKSELRMEVDDLAANVETLT 1288

Query: 367  KALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELEL 426
            +A      +A+ E+  R +E                          DQL+E  +++E EL
Sbjct: 1289 RA------KASAEKLCRTYE--------------------------DQLSEAKIKVE-EL 1315

Query: 427  QRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQH 486
            QR L              A  S Q    + E+G L  L  E   L  + Q+ +G+     
Sbjct: 1316 QRQL--------------ADASTQRGRLQTESGELSRLLEEKECL--ISQLSRGKALAAQ 1359

Query: 487  PLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAE 546
             L E  R+      LEE  +   A  H+ Q L            DL     +   EA AE
Sbjct: 1360 SLEELRRQ------LEEESKAKSALAHAVQALRHDC--------DLLREQHEEEAEAQAE 1405

Query: 547  CPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAP 606
              +               +  + + + W  +     ++  E  E+A ++ +L+       
Sbjct: 1406 LQRL-------------LSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRL------ 1446

Query: 607  PQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLE-EQEG 665
                                +EA +G           E    K    E + ++L+ E E 
Sbjct: 1447 --------------------QEAEEG----------VEAANAKCSSLEKAKLRLQTESED 1476

Query: 666  PNQGLDLATGQAEAREHDQR-LEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGV 724
                L+ AT  A A +  QR LE  + +   Q+ + + E                L +  
Sbjct: 1477 VTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRE----------------LEAAQ 1520

Query: 725  AEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAE 784
             E   L  E+ +LR   E   + LE   R+ +    E + L+ +++ + ++  E  +  +
Sbjct: 1521 RESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKK 1580

Query: 785  AQAWEQARLREAVEAAGQELESASQE----REALVEALAAAGRERRQWEREGSRLRAQSE 840
            A   E++ ++ A+E A   LE    +    +  L +  A   R+  + + E + LR   +
Sbjct: 1581 ALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQ 1640

Query: 841  AAEERMQV-LESEGRQHLEEAERERREKEA----LQAELEKAVVRGKELGARLEHLQREL 895
             A E +Q  L++E R    EA R +++ E     L+ +L  A  +  E  A    +Q +L
Sbjct: 1641 RAVESLQASLDAETRAR-NEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQL 1699

Query: 896  EQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQL-EEELFQ 954
            ++    R E  R     H++ Q LE+R  A L AA   +  A +E   R+ +L E+EL +
Sbjct: 1700 KEEQAGRDEEQRLAAELHEQAQALERR--ASLLAAELEELRAALEQGERSRRLAEQELLE 1757

Query: 955  L--------RQGPAGLGPKKRAEPQLVE-TQNVRLIEVERSNAMLVAEKAALQGQLQHLE 1005
                      Q    L  KK+ E  L + +  V     ER  A   A+KA     +    
Sbjct: 1758 ATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMM--- 1814

Query: 1006 GQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQE 1065
                     A+EL    ++ Q+ S+ L+  K  LE   +EL  +LE  E           
Sbjct: 1815 ---------AEEL----KKEQDTSAHLERMKKTLEQTVRELQARLEEAE----------- 1850

Query: 1066 ETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRE-LQG--RHEQ 1122
                  QA LR  K           +++ L  + R+L+A + A +  H E L+G  +HE+
Sbjct: 1851 ------QAALRGGK----------KQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHER 1894

Query: 1123 LQAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSR--ERG 1180
                      +E+A  AE +R            + L R+Q   D+ Q  +    R  E  
Sbjct: 1895 --------RVKELAYQAEEDR------------KNLARMQDLVDKLQSKVKSYKRQFEEA 1934

Query: 1181 ELQGERGELRGRLARLELERAQ-----LEMQSQQLR 1211
            E Q      + R A+ EL+ A+      E Q+ +LR
Sbjct: 1935 EQQANTNLAKYRKAQHELDDAEERADMAETQANKLR 1970



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 169/720 (23%), Positives = 293/720 (40%), Gaps = 129/720 (17%)

Query: 657  SVQLEEQ----EGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWE 712
            S Q EE+        +GL  A   AEA+   Q LE T         Q+K++ AL++Q  +
Sbjct: 891  SAQAEEELAALRAELRGLRGALAAAEAKR--QELEETHVSIT----QEKNDLALQLQAEQ 944

Query: 713  GPIPGESLASGVAEQEALREEVAQLRRKAEALGDELE----------AQARKLEAQNTEA 762
                 ++LA        L +   QL  K + L + LE          A+ RKLE + TE 
Sbjct: 945  -----DNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTE- 998

Query: 763  ARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEA----- 817
              L K++   +   A+A +E +A   +   L E + A  + +   ++E++AL EA     
Sbjct: 999  --LKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQAL 1056

Query: 818  ---------LAAAGRERRQWERE----------GSRLRAQSEAAEERM-------QVLES 851
                     ++A  + + + E++            +LR  +E A+ ++       Q   +
Sbjct: 1057 GDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVA 1116

Query: 852  EGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKES 911
            +  Q  ++ E + ++K++  ++L   V   + LGA+++   +EL+  A E +E L  + +
Sbjct: 1117 DAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERA 1176

Query: 912  QHQRYQGLEQRLEA--ELQAAATSKEEA---------------------LMELKTRALQL 948
               R +  +QR EA  EL+  +   EEA                       EL+  AL+ 
Sbjct: 1177 ARARVE--KQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRH 1234

Query: 949  EEELFQLR----QGPAGLGPK----KRAEPQLVETQNVRLIEVERSNA---MLVAEKAAL 997
            E  +  LR    +G A LG +    +R   +L + ++   +EV+   A    L   KA+ 
Sbjct: 1235 EATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASA 1294

Query: 998  QGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEV 1057
            +   +  E QL   + + +EL  Q   A     RLQ E   L    +E    +  L    
Sbjct: 1295 EKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGK 1354

Query: 1058 RAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQ 1117
              A QS EE R Q +   +   ALA   +    + + L  +H +       L+   R L 
Sbjct: 1355 ALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQ---RLLS 1411

Query: 1118 GRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSR 1177
              + ++   R+  EA  +    E E        ++ L   L+  +   + A    + L +
Sbjct: 1412 KANAEVAQWRSKYEADAIQRTEELE------EAKKKLALRLQEAEEGVEAANAKCSSLEK 1465

Query: 1178 ERGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSA 1237
             +  LQ E  ++   L R     A L+ + + L  + ++                  R  
Sbjct: 1466 AKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEE------------------RRR 1507

Query: 1238 QEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMD 1297
            QEEE ++   E++A  RE+R L       R H H E    L+ L  L+RE + L E+I D
Sbjct: 1508 QEEEMQR---ELEAAQRESRGLGTELFRLR-HGHEEA---LEALETLKRENKNLQEEISD 1560



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 98/389 (25%), Positives = 156/389 (40%), Gaps = 50/389 (12%)

Query: 129  SEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGVVLA 188
            SE+   +LE           +  H E  +   +    E+Q EL AA +E    G  +   
Sbjct: 1474 SEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRL 1533

Query: 189  LSGPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPL---------CL 239
              G +    A   L+  +++L   +S L  +  L  + + EL   ++ L          L
Sbjct: 1534 RHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAAL 1593

Query: 240  RPEAPSRAPAEGPSHHLALQLANAKAQL-RRLRQELEEKAELLLDSQAEVQGLEAEI--- 295
                 +    E  +  + L+L+  KA++ R+L ++ EE A L  + Q  V+ L+A +   
Sbjct: 1594 EEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAE 1653

Query: 296  RRLRQEAQALS--------------GQAKRAELYREEAEAL------RERAGR--LPRLQ 333
             R R EA  L               G A R     + A  L       E+AGR    RL 
Sbjct: 1654 TRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLA 1713

Query: 334  EELRRCRERLQA-AEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENL 392
             EL    + L+  A    ++LEE R      E S+ L E++L  A ER   LH    +N 
Sbjct: 1714 AELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHS---QNT 1770

Query: 393  LLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSL--------EPPPGSPGEAPLAG 444
             L  +  +  A+L  L  +V++ A+E  E E + ++++        E        A L  
Sbjct: 1771 GLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1830

Query: 445  AAPSLQDEVREAEAGRLRTLERENRELRG 473
               +L+  VRE +A   R  E E   LRG
Sbjct: 1831 MKKTLEQTVRELQA---RLEEAEQAALRG 1856



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 75/317 (23%), Positives = 133/317 (41%), Gaps = 44/317 (13%)

Query: 1019 LLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDH 1078
            LL+S +A+E  + L+AE              L  L   + AA   ++E      ++ ++ 
Sbjct: 888  LLRSAQAEEELAALRAE--------------LRGLRGALAAAEAKRQELEETHVSITQEK 933

Query: 1079 KALA-QLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVAL 1137
              LA QLQ  Q+   +     H  +K+ ++ LE   +EL  R E  +   A + A     
Sbjct: 934  NDLALQLQAEQDNLADAEERCHLLIKSKVQ-LEGKVKELSERLEDEEEVNADLAA----- 987

Query: 1138 LAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLE 1197
                        R+R LE+E   L+ + D  ++ LA+  +E+   + +   L   +A L+
Sbjct: 988  ------------RRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALD 1035

Query: 1198 LERAQLEMQSQQLRESNQQL--DLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRE 1255
               A+L  + + L+E++QQ   DL A           +LR  Q+ E+ +   E +   R 
Sbjct: 1036 ESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRM 1095

Query: 1256 NRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPL---PRTKK 1312
            + E  +R LE    L +E       +    ++KQ+L EK+  +   L  + L        
Sbjct: 1096 DTERAKRKLEGDLKLTQE------SVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLL 1149

Query: 1313 GSWLADKVKRLMRPRRE 1329
            G+ +  K+K L     E
Sbjct: 1150 GAQMQKKIKELQARAEE 1166


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  147 bits (371), Expect = 7e-35
 Identities = 272/1114 (24%), Positives = 433/1114 (38%), Gaps = 99/1114 (8%)

Query: 256  LALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELY 315
            L  QLA+ ++    L  EL E  +LL +  A++  ++  I RL      L+ +   + L 
Sbjct: 219  LKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLA----LLNEKQAASPLE 274

Query: 316  REEAEALRERAGRLP-RLQEELRRCR----ERLQAAEAYKSQLEEERVLSGVLEASKALL 370
             +E E LR++   L  RL E L++C+    E+ Q         EE   LS  L    + L
Sbjct: 275  PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL 334

Query: 371  EEQLEAARERCARLHETQRENL----LLRTRLGEAHAELDSLRHQVDQLAEENVELELEL 426
            ++  +A  E      +  +E L     L   L  A  +   L  + + L  +  +LE  L
Sbjct: 335  QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHL 394

Query: 427  QRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQH 486
             +  + PP   GE         LQ E  + EA    TL   N +L+  +++L+ + G Q 
Sbjct: 395  SQLQDNPPQEKGEV----LGDVLQLETLKQEAA---TLAANNTQLQARVEMLETERGQQE 447

Query: 487  PLLEAPR-----EDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVL 541
              L A R     E   L  L    Q+ ++     +  +++A       L     +L S L
Sbjct: 448  AKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSEL 507

Query: 542  EASAECPQAPDSD----PQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSS 597
                   Q  D +     Q+A+      A   Q  + + Q     VE   S  K      
Sbjct: 508  TTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKE--- 564

Query: 598  LQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSS 657
             Q    VA  Q   T+    Q L    E REA   E       L+Q     K   ++   
Sbjct: 565  -QQLKEVAEKQ-EATRQDHAQQLATAAEEREASLRE---RDAALKQLEALEKEKAAKLEI 619

Query: 658  VQLEEQEGPNQGLDLA-TGQAEAREHDQRLEGTVRD-PAWQKPQQKSEGALEVQVWEGPI 715
            +Q + Q   N+  D A T   +A+     L   V +  A  +  ++ +   + QV E  +
Sbjct: 620  LQQQLQVA-NEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELEL 678

Query: 716  PGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAA-------RLSKE 768
               S      E+E + +E  QL+ + +AL + L+     LE +   AA       R   E
Sbjct: 679  QLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISE 738

Query: 769  LAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQE-----REALVEALAAAGR 823
            L    R+  E H+    +  E+   R+ +EA  Q+L  A Q      R  L EA+AA   
Sbjct: 739  LKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHT 798

Query: 824  ERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKA--VVRG 881
               + E+    + A  E  E+  Q     G    E+    + E E  + EL++A   V G
Sbjct: 799  AESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAG 858

Query: 882  KELGARLE--HLQRELEQAALERQEFLREKESQHQRYQGLEQRLEA-ELQAAATSKEEAL 938
             E  + L+    Q EL +        L++ + +  R Q L   L   + + AATSKE A 
Sbjct: 859  IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVAR 918

Query: 939  MELKTRAL--QLEEELFQLRQGPAGLGPKKRAEPQLVETQNVR-LIEVERSNAMLVAEKA 995
            +E   R    Q E    +L + PA  G +   +P+ +E Q  R     + +   +  E  
Sbjct: 919  LETLVRKAGEQQETASRELVKEPARAGDR---QPEWLEEQQGRQFCSTQAALQAMEREAE 975

Query: 996  ALQGQLQHLEGQLGSLQGRAQELLLQSQ----RAQEHSSRLQAEKSVLEIQGQELHRKLE 1051
             +  +L+ L   L   QG+ QE   Q +    R  +   R QA+ ++ +    EL  +L+
Sbjct: 976  QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1035

Query: 1052 VLEEEVR--------AARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLK 1103
                E R        A   +  E  G+ Q L +    L  L+  Q  ELE L    + LK
Sbjct: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQELAK----LRGLEAAQIKELEELRQTVKQLK 1091

Query: 1104 ANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQR----GLEEELR 1159
              +   E  H    G   +   +      +  AL AE  +L Q   +Q+     LE  L 
Sbjct: 1092 EQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLE 1151

Query: 1160 RLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLDL 1219
              ++        L  L  +  E   E G  +  LA  + E A    + Q   ++  +   
Sbjct: 1152 AERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKA 1211

Query: 1220 SACRLTTQCELLTQLRSAQEEE----NRQLLAEVQALSRENRELL----ERSLESRDHLH 1271
               R   + E    L S+ EEE    NRQ+L E +  S+E + L+    E+S +  + L 
Sbjct: 1212 QVARGRQEAERKNSLISSLEEEVSILNRQVL-EKEGESKELKRLVMAESEKSQKLEERLR 1270

Query: 1272 REQRE-------YLDQLNALRREKQKLVEKIMDQ 1298
              Q E         ++ +ALR E Q L E+   Q
Sbjct: 1271 LLQAETASNSARAAERSSALREEVQSLREEAEKQ 1304



 Score =  146 bits (369), Expect = 1e-34
 Identities = 301/1228 (24%), Positives = 490/1228 (39%), Gaps = 195/1228 (15%)

Query: 144  LGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELE 203
            L A++Q + +EL    ++  + E Q++LA  +Q+  Q   G+   +      E   + L+
Sbjct: 510  LNATIQQQDQEL--AGLKQQAKEKQAQLAQTLQQQEQASQGLRHQV------EQLSSSLK 561

Query: 204  MLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANA 263
               + L     K    R   AQ+LA    ERE   LR    +    E      A +L   
Sbjct: 562  QKEQQLKEVAEKQEATRQDHAQQLATAAEEREA-SLRERDAALKQLEALEKEKAAKLEIL 620

Query: 264  KAQLR-----------RLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRA 312
            + QL+            + Q   EKAEL      +V+ L+A +   RQE      Q    
Sbjct: 621  QQQLQVANEARDSAQTSVTQAQREKAEL----SRKVEELQACVETARQEQHEAQAQVAEL 676

Query: 313  ELY-REEAEALRER---AGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKA 368
            EL  R E +   E+   A    +LQE+L+  +E L+     K  LEEE+        +  
Sbjct: 677  ELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVT---KGSLEEEK------RRAAD 727

Query: 369  LLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQR 428
             LEEQ     E  A       ++   R  L E  A    L  ++ QL E +      L+R
Sbjct: 728  ALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRR 787

Query: 429  SLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPL 488
             L     +   A    A    +  V+E  A R R  + +  E +    + Q Q       
Sbjct: 788  EL-----AEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQ-YGAMFQEQLMTLKEE 841

Query: 489  LEAPREDPVLPVLEEAPQTPVAFD-HSPQGLVQKARDGGPQALDLAPPALDSVLEASAEC 547
             E  R++     L+EA +     + HS   + ++  +      +LA  AL  V E     
Sbjct: 842  CEKARQE-----LQEAKEKVAGIESHSELQISRQQNELAELHANLAR-ALQQVQEKEVRA 895

Query: 548  PQAPD--SDPQE--AESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPAS 603
             +  D  S  QE  A +  + A ++        Q+  +  E  + P +AG R     P  
Sbjct: 896  QKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQ----PEW 951

Query: 604  VAPPQG-----PGTKIQA----PQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSE 654
            +   QG         +QA     + +G E E   A     + E+ G +QE    + G  E
Sbjct: 952  LEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAA----LMESQGQQQE----ERGQQE 1003

Query: 655  PSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGP 714
                +L ++ G  Q  DLA  +A   E + RL+  + +   +    +   A  +   EG 
Sbjct: 1004 REVARLTQERGRAQA-DLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGK 1062

Query: 715  IPGESLASG-----VAEQEALREEVAQLRRK--------AEALGDELEAQAR------KL 755
                +   G     + E E LR+ V QL+ +        A   G + EA  R      KL
Sbjct: 1063 DQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKL 1122

Query: 756  EAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALV 815
            EA   E ++L ++  + +       R  EA+   +A    A+E    +LE  +QE     
Sbjct: 1123 EALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQ 1182

Query: 816  EALAAAGRE--------------RRQWEREGSRLRAQSE-------AAEERM-----QVL 849
             ALA+A RE                +W+ + +R R ++E       + EE +     QVL
Sbjct: 1183 SALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVL 1242

Query: 850  ESEGR----QHLEEAERERREK-----EALQAELE----KAVVRGKELGARLEHLQRELE 896
            E EG     + L  AE E+ +K       LQAE      +A  R   L   ++ L+ E E
Sbjct: 1243 EKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAE 1302

Query: 897  QAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELK-----TRALQLE-- 949
            +  +  +   +E  SQ +R + L Q L+A  Q     KE+AL  L+     T+AL  E  
Sbjct: 1303 KQRVASENLRQELTSQAERAEELGQELKA-WQEKFFQKEQALSTLQLEHTSTQALVSELL 1361

Query: 950  ---------------------EELFQLRQGPAGLGPKK-RAEPQLVETQNVR--LIEVER 985
                                 EEL Q +Q   GL  +  RA+ +L E   +R  + E ER
Sbjct: 1362 PAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQER 1421

Query: 986  SNAMLVAEKAALQGQLQHLE-------------GQLGSLQGRAQELLLQSQR---AQEHS 1029
            +   L AEKA+   QL  L+             G+  +L  +  E+ L   R    QE +
Sbjct: 1422 TAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELA 1481

Query: 1030 S-RLQAEKSVLEIQ--GQELHRKLEVLEEEVRAAR----QSQEETRGQQQALLRDHKALA 1082
            + R  AE  + E+Q   Q   R+LEV+  +   A+    + ++  + ++Q L    + L 
Sbjct: 1482 AVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLE 1541

Query: 1083 QLQRRQEAELEGLLVR--HRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEV-ALLA 1139
              QR Q  ++E L  +    D  + ++  +L   + QG   Q +AQR   +  E+ A L+
Sbjct: 1542 VFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLS 1601

Query: 1140 ERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELE 1199
            ++E+  +  H +  +E+      ++  + Q L  +L R   +LQ E  ELR    RL  E
Sbjct: 1602 QKEQAAE--HYKLQMEKAKTHYDAKKQQNQELQEQL-RSLEQLQKENKELRAEAERLGHE 1658

Query: 1200 RAQLEMQSQQLRESNQQLDLSACRLTTQ 1227
              Q  +++++  ++ + L      L  Q
Sbjct: 1659 LQQAGLKTKEAEQTCRHLTAQVRSLEAQ 1686



 Score =  142 bits (358), Expect = 2e-33
 Identities = 296/1298 (22%), Positives = 533/1298 (41%), Gaps = 174/1298 (13%)

Query: 97   LWGRLRDFYQEELQLLILSPPPDL-----QTLGFDPLSEEAVE------QLEGVLRLLLG 145
            L G+L    +E L  L  +PP +        L  + L +EA        QL+  + +L  
Sbjct: 383  LQGKLSQL-EEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLET 441

Query: 146  ASVQCEHRELFIR-HIQGLSLEVQS---ELAAAIQEVTQPGAGVVLALSGPDPGELAPAE 201
               Q E + L  R H +    ++ S   +L ++I  ++Q  A   L  +    G    A+
Sbjct: 442  ERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQ--AKEELEQASQAHGARLTAQ 499

Query: 202  LEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLA 261
            +  L+  L  TL+   +++D     L +   E++    +        ++G  H +  QL+
Sbjct: 500  VASLTSELT-TLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVE-QLS 557

Query: 262  NAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRR--LRQEAQALSGQAKRAELYREEA 319
            ++  Q  +  +E+ EK E      A+     AE R   LR+   AL           ++ 
Sbjct: 558  SSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAAL-----------KQL 606

Query: 320  EAL-RERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERV-LSGVLEASKALLEEQLEAA 377
            EAL +E+A +L  LQ++L+   E   +A+   +Q + E+  LS  +E  +A +E   +  
Sbjct: 607  EALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQ 666

Query: 378  RERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSP 437
             E  A++ E +   L LR+   +A  E + +  + DQL E+   L+     SL+   GS 
Sbjct: 667  HEAQAQVAELE---LQLRSEQQKA-TEKERVAQEKDQLQEQLQALK----ESLKVTKGSL 718

Query: 438  GEAPLAGAAPSLQDEVR---EAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLE-APR 493
             E     AA +L+++ R   E +A     +E+  RE + L +   G+ G +  L +    
Sbjct: 719  EEEKRR-AADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEA 777

Query: 494  EDPVLPVLEEAPQTPVAFDHSPQG----LVQKA-------RDGGPQALDLAPPALDSVLE 542
                  VL       +A  H+ +     LV++         D   +         + ++ 
Sbjct: 778  HQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMT 837

Query: 543  ASAECPQAPDSDPQ--------EAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGR 594
               EC +A     +        E+ S LQ +    Q ++ +   +      Q+  EK  R
Sbjct: 838  LKEECEKARQELQEAKEKVAGIESHSELQISR---QQNELAELHANLARALQQVQEKEVR 894

Query: 595  RSSLQSPASVAPPQGPGTKIQAPQL---LGGETEGREAPQGELVPEAWGLRQEGPEHKPG 651
               L    S    +   T  +  +L   +    E +E    ELV E        PE    
Sbjct: 895  AQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEW--- 951

Query: 652  PSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQ------RLEGTVRDPAWQKPQQKSEGA 705
                    LEEQ+G       A  QA  RE +Q      RL   + +   Q+ +++ +  
Sbjct: 952  --------LEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQE 1003

Query: 706  LEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARK-LEAQNTEAAR 764
             EV             + + ++    +    L + A A   ELE + +  L  Q  E A 
Sbjct: 1004 REV-------------ARLTQERGRAQADLALEKAARA---ELEMRLQNALNEQRVEFAT 1047

Query: 765  LSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRE 824
            L + LA A         E E +  E A+LR    A  +ELE   Q  + L E LA   +E
Sbjct: 1048 LQEALAHALT-------EKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKE 1100

Query: 825  RRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKEL 884
                    S    ++E    +++ L +E  +  ++ ++++ + ++L+  LE       E 
Sbjct: 1101 HASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAER 1160

Query: 885  GARLEHLQRELEQAALE-----------RQEF--LREKESQHQ------RYQGLEQRLEA 925
             + LE LQ +LE+ A E           ++E    R K   H       + Q    R EA
Sbjct: 1161 DSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEA 1220

Query: 926  ELQ-AAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVE 984
            E + +  +S EE +  L  + L+ E E  +L++    L   +  + Q +E + +RL++ E
Sbjct: 1221 ERKNSLISSLEEEVSILNRQVLEKEGESKELKR----LVMAESEKSQKLE-ERLRLLQAE 1275

Query: 985  -RSNAMLVAEK-AALQGQLQHL----EGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSV 1038
              SN+   AE+ +AL+ ++Q L    E Q  + +   QEL  Q++RA+E    L+A +  
Sbjct: 1276 TASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEK 1335

Query: 1039 LEIQGQEL------HRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAEL 1092
               + Q L      H   + L  E+  A+   ++ + +Q A  + H+   +  ++    L
Sbjct: 1336 FFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGL 1395

Query: 1093 EGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQR 1152
               L+R +     +  L     E +   +QL+A++AS  A+++++L +   L+ + +R  
Sbjct: 1396 RAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASY-AEQLSMLKKAHGLLAEENRGL 1454

Query: 1153 GLEEELRR--LQSEHDRA-QMLLAELSRERGELQGERGEL----RGRLARLELERAQLEM 1205
            G    L R  L+ E D+A +  + EL+  R + +    E+    +     LE+  A+ E 
Sbjct: 1455 GERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEG 1514

Query: 1206 QSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLE 1265
               ++ E  Q+      +LT Q E   QL   Q E+ +Q+            E L + L 
Sbjct: 1515 AKVKVLEERQRFQEERQKLTAQVE---QLEVFQREQTKQV------------EELSKKLA 1559

Query: 1266 SRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLE 1303
              D   + Q++ L  + A   E Q+  +++  Q   L+
Sbjct: 1560 DSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQ 1597



 Score =  112 bits (281), Expect = 2e-24
 Identities = 150/646 (23%), Positives = 278/646 (43%), Gaps = 70/646 (10%)

Query: 732  EEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQA 791
            +E+ +LR K E+L   L    ++ +   TE +++ +++ Q      +   +    A    
Sbjct: 276  KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQ 335

Query: 792  RLREAVEAAGQELESASQE----REALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQ 847
            +L++A+    +E   A+QE    +  L + L+AA ++++  E +   L+ +    EE + 
Sbjct: 336  QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLS 395

Query: 848  VLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAAL----ERQ 903
             L+    Q   E   +  + E L+ E         +L AR+E L+ E  Q       ER 
Sbjct: 396  QLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERG 455

Query: 904  EFLREKE--------------SQHQRYQGLEQRLEAE---LQAAATSKEEALMELKTRAL 946
             F  EK+              +  Q  + LEQ  +A    L A   S    L  L     
Sbjct: 456  HFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQ 515

Query: 947  QLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEG 1006
            Q ++EL  L+Q        K  + QL +T    L + E+++  L  +   L   L+  E 
Sbjct: 516  QQDQELAGLKQ------QAKEKQAQLAQT----LQQQEQASQGLRHQVEQLSSSLKQKEQ 565

Query: 1007 QLGSL--------QGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVR 1058
            QL  +        Q  AQ+L   ++  +       A    LE   +E   KLE+L+++++
Sbjct: 566  QLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQ 625

Query: 1059 AARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQG 1118
             A ++++     Q ++ +  +  A+L R+ E EL+  +   R  +   +A ++A  ELQ 
Sbjct: 626  VANEARDSA---QTSVTQAQREKAELSRKVE-ELQACVETARQEQHEAQA-QVAELELQL 680

Query: 1119 RHEQLQAQRASVEAQEVALLAERERLMQDGHR--QRGLEEELRRLQSEHDRAQMLLAEL- 1175
            R EQ +A      AQE   L E+ + +++  +  +  LEEE RR     +  Q  ++EL 
Sbjct: 681  RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740

Query: 1176 ----------SRERGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLT 1225
                       RER EL+ ER   +G  ARL+      + +++ LR    +   +     
Sbjct: 741  AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAE 800

Query: 1226 TQCELLTQLRSA---QEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLN 1282
            ++CE L +  +A   + E+++Q  A+  A+ +E    L+   E      +E +E +  + 
Sbjct: 801  SECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIE 860

Query: 1283 A-----LRREKQKLVEKIMDQYRVLEPVPLPRTKKGSWLADKVKRL 1323
            +     + R++ +L E   +  R L+ V   +  +   LAD +  L
Sbjct: 861  SHSELQISRQQNELAELHANLARALQQVQ-EKEVRAQKLADDLSTL 905



 Score =  111 bits (278), Expect = 5e-24
 Identities = 238/1068 (22%), Positives = 389/1068 (36%), Gaps = 189/1068 (17%)

Query: 87   AAWRVWNLNHLWGRLRDFYQEELQLLILSPPPDLQTLGFDPLSEEAVEQLEGVLRLLLGA 146
            AAWR         R  D  QEE Q   +      Q +      E+A ++L+     + G 
Sbjct: 811  AAWRE--------RYEDSQQEEAQYGAMFQE---QLMTLKEECEKARQELQEAKEKVAGI 859

Query: 147  SVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLS 206
                 H EL I   Q    E+ + LA A+Q+V                      E E+ +
Sbjct: 860  E---SHSELQISRQQNELAELHANLARALQQV---------------------QEKEVRA 895

Query: 207  RSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQ 266
            + L   LS L  +    ++ +A L         + E  SR   + P          A+A 
Sbjct: 896  QKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEP----------ARAG 945

Query: 267  LRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERA 326
             R+     E++      +QA +Q +E E  ++  E + L      ++  ++E    +ER 
Sbjct: 946  DRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQER- 1004

Query: 327  GRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHE 386
              + RL +E  R +  L   +A +++LE        +    AL E+++E A  + A  H 
Sbjct: 1005 -EVARLTQERGRAQADLALEKAARAELE--------MRLQNALNEQRVEFATLQEALAHA 1055

Query: 387  -TQRENL---LLRTRLGEAH--AELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEA 440
             T++E     L + R  EA    EL+ LR  V QL E+  + E       E   GS  ++
Sbjct: 1056 LTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKE------KEHASGSGAQS 1109

Query: 441  PLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPV 500
              AG          E    +L  L  E  +L    Q  Q Q       LEA R       
Sbjct: 1110 EAAGRT--------EPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAER------- 1154

Query: 501  LEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAES 560
                                          D A   L   LE  A+  +   S    A +
Sbjct: 1155 ------------------------ASRAERDSALETLQGQLEEKAQ--ELGHSQSALASA 1188

Query: 561  PLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLL 620
              + AA   +  D S  E     +     ++A R++SL S             I   Q+L
Sbjct: 1189 QRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLE------EEVSILNRQVL 1242

Query: 621  GGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAR 680
              E E +E  +  +                      S +LEE+    Q  + A+  A A 
Sbjct: 1243 EKEGESKELKRLVMA-----------------ESEKSQKLEERLRLLQA-ETASNSARAA 1284

Query: 681  EHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRK 740
            E    L   V+    +  +Q+                          E LR+E+     +
Sbjct: 1285 ERSSALREEVQSLREEAEKQR-----------------------VASENLRQELTSQAER 1321

Query: 741  AEALGDELEAQARK----------LEAQNTEAARLSKELAQARRAEAEAHRE-AEAQAWE 789
            AE LG EL+A   K          L+ ++T    L  EL  A+    +   E A A+   
Sbjct: 1322 AEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRH 1381

Query: 790  QARLREAVEAAG---QELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERM 846
            +  L ++ +AAG    EL  A +E   L+        +    ER   +LRA+  +  E++
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQ----ERTAQQLRAEKASYAEQL 1437

Query: 847  QVLESEGRQHLEE----AERERREKEALQAELEKAVVR-GKELGARLEHLQRELEQAALE 901
             +L+       EE     ER    ++ L+ EL++A  +  +EL A     +  L +   E
Sbjct: 1438 SMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQRE 1497

Query: 902  RQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAG 961
             Q   RE E    +Y+G + ++  E Q     +++   +++   +   E+  Q+ +    
Sbjct: 1498 AQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEE---- 1553

Query: 962  LGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQ 1021
            L  K     Q  + Q  +L  V+        E   LQ QL  L+ QL   +  A+   LQ
Sbjct: 1554 LSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQ 1613

Query: 1022 SQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKAL 1081
             ++A+ H    + +   L    QE  R LE L++E +  R   E    + Q      K  
Sbjct: 1614 MEKAKTHYDAKKQQNQEL----QEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEA 1669

Query: 1082 AQLQRRQEAELEGL--LVRHRDLK-ANMRALELAHRELQGRHEQLQAQ 1126
             Q  R   A++  L   V H D +  ++   ++A   L+ R  Q + Q
Sbjct: 1670 EQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQ 1717



 Score =  110 bits (274), Expect = 1e-23
 Identities = 235/1023 (22%), Positives = 385/1023 (37%), Gaps = 188/1023 (18%)

Query: 195  GELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSH 254
            GE   AE E+L R L   ++         AQ  AE   E+    ++  A  R   E    
Sbjct: 775  GEAHQAETEVLRRELAEAMA---------AQHTAESECEQ---LVKEVAAWRERYEDSQQ 822

Query: 255  HLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAEL 314
              A   A  + QL  L++E E+  + L +++ +V G+E+       E Q    Q + AEL
Sbjct: 823  EEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESH-----SELQISRQQNELAEL 877

Query: 315  YREEAEALR---ERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLE--ASKAL 369
            +   A AL+   E+  R  +L ++L   +E++ A     ++LE     +G  +  AS+ L
Sbjct: 878  HANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASREL 937

Query: 370  LEEQLEAA------------RERC---ARLHETQRE-----NLLLRTRL------GEAHA 403
            ++E   A             R+ C   A L   +RE     N L R R       G+   
Sbjct: 938  VKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQE 997

Query: 404  ELDSLRHQVDQLAEEN--------------VELELELQRSLEPPPGSPGEAPLAGAAPSL 449
            E      +V +L +E                ELE+ LQ +L            A A    
Sbjct: 998  ERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALT 1057

Query: 450  QDEVREAEAGRLRTLE----RENRELRGLLQVLQGQ---------PGGQHPLLEAPREDP 496
            + E ++ E  +LR LE    +E  ELR  ++ L+ Q          G       A R +P
Sbjct: 1058 EKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEP 1117

Query: 497  VLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQAL----------DLAPPALDSVLEASAE 546
              P LE         +   Q   ++A D   ++L          D A   L   LE  A+
Sbjct: 1118 TGPKLEALRAEVSKLEQQCQKQQEQA-DSLERSLEAERASRAERDSALETLQGQLEEKAQ 1176

Query: 547  CPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAP 606
              +   S    A +  + AA   +  D S  E     +     ++A R++SL S      
Sbjct: 1177 --ELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEE- 1233

Query: 607  PQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGP 666
                   I   Q+L  E E +E  +  +                      S +LEE+   
Sbjct: 1234 -----VSILNRQVLEKEGESKELKRLVMA-----------------ESEKSQKLEERLRL 1271

Query: 667  NQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAE 726
             Q  + A+  A A E    L   V+    +  +Q+                         
Sbjct: 1272 LQA-ETASNSARAAERSSALREEVQSLREEAEKQR-----------------------VA 1307

Query: 727  QEALREEVAQLRRKAEALGDELEAQARK----------LEAQNTEAARLSKELAQARRAE 776
             E LR+E+     +AE LG EL+A   K          L+ ++T    L  EL  A+   
Sbjct: 1308 SENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLC 1367

Query: 777  AEAHRE-AEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRL 835
             +   E A A+   +  L ++ +AAG       + +  L E +    +   Q ER   +L
Sbjct: 1368 QQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQ-ERTAQQL 1426

Query: 836  RAQSEAAEERMQVLESEGRQHLEE----AERERREKEALQAELEKAVVRG-KELGARLEH 890
            RA+  +  E++ +L+       EE     ER    ++ L+ EL++A  +  +EL A    
Sbjct: 1427 RAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRAD 1486

Query: 891  LQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEE 950
             +  L +   E Q   RE E    +Y+G + ++  E Q     +++   +++   +   E
Sbjct: 1487 AETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE 1546

Query: 951  ELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGS 1010
            +  Q+ +    L  K     Q  + Q  +L  V+        E   LQ QL  L+ QL  
Sbjct: 1547 QTKQVEE----LSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQ 1602

Query: 1011 LQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQ 1070
             +  A+   LQ ++A+ H     A+K     Q QEL       +E++R+  Q Q+E +  
Sbjct: 1603 KEQAAEHYKLQMEKAKTH---YDAKKQ----QNQEL-------QEQLRSLEQLQKENK-- 1646

Query: 1071 QQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASV 1130
                          + R EAE  G  ++   LK   +  E   R L  +   L+AQ A  
Sbjct: 1647 --------------ELRAEAERLGHELQQAGLKT--KEAEQTCRHLTAQVRSLEAQVAHA 1690

Query: 1131 EAQ 1133
            + Q
Sbjct: 1691 DQQ 1693



 Score = 91.7 bits (226), Expect = 5e-18
 Identities = 131/548 (23%), Positives = 235/548 (42%), Gaps = 58/548 (10%)

Query: 801  GQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEA 860
            G ELE A      L  +  ++ +  R WE+     + Q+E A     VL+ E   +L E 
Sbjct: 90   GSELELAKMTMLLLYHSTMSS-KSPRDWEQ--FEYKIQAELAVILKFVLDHEDGLNLNED 146

Query: 861  ERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALER-------QEFLREKESQH 913
                 +K  + +         +EL       +RE+    L++         FL    +  
Sbjct: 147  LENFLQKAPVPSTCSSTFP--EELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASP 204

Query: 914  -----QRYQGLEQRLEAELQAAATSKEEALMEL-KTRALQLEEE--------------LF 953
                 Q  Q   +RL+ +L    ++++E  +EL + R L  E++              L 
Sbjct: 205  MGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALL 264

Query: 954  QLRQGPAGLGPKKRAEPQ-LVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQ 1012
              +Q  + L PK+  E +   E+  +RL E  +    L  EK+ +  ++  L  + G L 
Sbjct: 265  NEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLS 324

Query: 1013 GRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQS----QEETR 1068
             + +E     Q+ Q+  + L  E S      QE   K   LE+E+ AA Q     +E+  
Sbjct: 325  FKLREFASHLQQLQDALNELTEEHSKAT---QEWLEKQAQLEKELSAALQDKKCLEEKNE 381

Query: 1069 GQQQALLRDHKALAQLQR---RQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQA 1125
              Q  L +  + L+QLQ    +++ E+ G +++   LK     L   + +LQ R E L+ 
Sbjct: 382  ILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLET 441

Query: 1126 QRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERG----- 1180
            +R     QE  LLAER    ++  +   L  +L+   S   +A+  L + S+  G     
Sbjct: 442  ERGQ---QEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTA 498

Query: 1181 ---ELQGERGELRGRLARLELERAQLEMQSQ----QLRESNQQLDLSACRLTTQCELLTQ 1233
                L  E   L   + + + E A L+ Q++    QL ++ QQ + ++  L  Q E L+ 
Sbjct: 499  QVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSS 558

Query: 1234 LRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVE 1293
                +E++ +++  + +A  +++ + L  + E R+   RE+   L QL AL +EK   +E
Sbjct: 559  SLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLE 618

Query: 1294 KIMDQYRV 1301
             +  Q +V
Sbjct: 619  ILQQQLQV 626



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 133/638 (20%), Positives = 233/638 (36%), Gaps = 89/638 (13%)

Query: 200  AELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQ 259
            AE +    +L G L + A+E  LG  + A    +RE    R +    + AE         
Sbjct: 1158 AERDSALETLQGQLEEKAQE--LGHSQSALASAQRELAAFRTKVQDHSKAED-------- 1207

Query: 260  LANAKAQLRRLRQELEEKAELLLDSQAEVQGL-------EAEIRRLRQEAQALSGQAKRA 312
                KAQ+ R RQE E K  L+   + EV  L       E E + L++   A S ++++ 
Sbjct: 1208 --EWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKL 1265

Query: 313  E-----LYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASK 367
            E     L  E A      A R   L+EE++  RE  +        L +E  L+   E ++
Sbjct: 1266 EERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQE--LTSQAERAE 1323

Query: 368  ALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQ 427
             L +E L+A +E+  +  +      L  T      +EL   +H   QL  E    E   +
Sbjct: 1324 ELGQE-LKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHR 1382

Query: 428  RSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHP 487
              LE                    + ++A  G    L R  REL  L+ + Q        
Sbjct: 1383 EELE--------------------QSKQAAGGLRAELLRAQRELGELIPLRQ-------K 1415

Query: 488  LLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAE- 546
            + E  R    L   + +    ++      GL+ +   G  +  +L    L+  L+ + E 
Sbjct: 1416 VAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREK 1475

Query: 547  -----CPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSP 601
                      D++ + AE   +A +   +    + +  G+ V+  E       R   Q  
Sbjct: 1476 YVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEE------RQRFQEE 1529

Query: 602  ASVAPPQGPGTKI-QAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQL 660
                  Q    ++ Q  Q    E   ++    +   +    + +  + + G S+  + +L
Sbjct: 1530 RQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRL 1589

Query: 661  EEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESL 720
            + Q    Q     + + +A EH +      +     K QQ  E                L
Sbjct: 1590 QAQLNELQAQ--LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQE----------------L 1631

Query: 721  ASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAH 780
               +   E L++E  +LR +AE LG EL+    K +        L+   AQ R  EA+  
Sbjct: 1632 QEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLT---AQVRSLEAQV- 1687

Query: 781  REAEAQAWEQARLREAVEAAGQELESASQEREALVEAL 818
              A+ Q  +  + + A +A       A  + +  +++L
Sbjct: 1688 AHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSL 1725



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 67/275 (24%), Positives = 124/275 (45%), Gaps = 23/275 (8%)

Query: 201  ELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQL 260
            ELE+++    G   K+  ER    +   +L  + E L +     ++   E  S  LA   
Sbjct: 1504 ELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQ-VEELSKKLADSD 1562

Query: 261  ANAKAQLRRLRQ------ELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAEL 314
              +K Q ++L+       E +++A+ L   QA++  L+A++ +  Q A+    Q ++A+ 
Sbjct: 1563 QASKVQQQKLKAVQAQGGESQQEAQRL---QAQLNELQAQLSQKEQAAEHYKLQMEKAKT 1619

Query: 315  Y----REEAEALRERAGRLPRLQEELRRCR---ERL--QAAEAYKSQLEEERVLSGVLEA 365
            +    +++ + L+E+   L +LQ+E +  R   ERL  +  +A     E E+     L A
Sbjct: 1620 HYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRH-LTA 1678

Query: 366  SKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELE 425
                LE Q+  A ++   L + Q     L++R  +A  +LD     +D   EE   L + 
Sbjct: 1679 QVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSIT 1738

Query: 426  LQRSLEPPPGS--PGEAPLAGAAPSLQDEVREAEA 458
             +     P G+  PGE P +  +  L  +V   E+
Sbjct: 1739 SKLPRTQPDGTSVPGE-PASPISQRLPPKVESLES 1772


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  141 bits (356), Expect = 4e-33
 Identities = 266/1194 (22%), Positives = 490/1194 (41%), Gaps = 173/1194 (14%)

Query: 258  LQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAK-RAELYR 316
            LQ+   + +++    EL++  E    ++ E++ LE +  +L +E   L  Q +   ELY 
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 317  EEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKAL-LEEQLE 375
            E  E     A +   L+E L     RL+  E    QL+ ER       A + L LEEQLE
Sbjct: 912  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM----AQQMLDLEEQLE 967

Query: 376  AARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPG 435
               E  AR  + Q E +    ++ +   E+  +  Q ++L++E   LE   +R  +    
Sbjct: 968  --EEEAAR-QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE---ERISDLTTN 1021

Query: 436  SPGEAPLAGAAPSLQDE----VREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPL--- 488
               E   A     L+++    + E E  RL+  E+  +EL  L + L+G     H     
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEV-RLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080

Query: 489  LEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECP 548
            L+A   +  + + ++  +   A       + QK              AL  + E      
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN------------ALKKIRELEGHI- 1127

Query: 549  QAPDSDPQEAESPLQAAA--MDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAP 606
                SD QE     +AA    + Q  D   +      E +++ +    +  L+     A 
Sbjct: 1128 ----SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR-----AK 1178

Query: 607  PQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGP 666
             +   T ++  + L  ET   EA   E+       RQ+  +      E  + QLE+ +  
Sbjct: 1179 REQEVTVLK--KALDEETRSHEAQVQEM-------RQKHAQ----AVEELTEQLEQFKRA 1225

Query: 667  NQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAE 726
               LD      E    D   E  V   A Q+ + K +  LE QV E       L S  ++
Sbjct: 1226 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK-KLEAQVQE-------LQSKCSD 1277

Query: 727  QEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQ 786
             E  R   A+L  K   L +E+E+    L     +A +L+K++A      +   ++ +  
Sbjct: 1278 GERAR---AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL----SSQLQDTQEL 1330

Query: 787  AWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERM 846
              E+ R +  V    ++LE   +ER +L + L      ++  ER  S L  Q   +++++
Sbjct: 1331 LQEETRQKLNVSTKLRQLE---EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387

Query: 847  QVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALE---RQ 903
            Q   S      E  +R ++E E L  + E+      +L      LQ+EL+   ++   ++
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1447

Query: 904  EFLREKESQHQRYQGL---EQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPA 960
            + +   E + +++  L   E+ + ++        E    E +T+AL L   L +  +   
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE--- 1504

Query: 961  GLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLL 1020
                   A+ +L  T  +   E+E     LV+ K  +   +  LE    +L+ + +E+  
Sbjct: 1505 -------AKEELERTNKMLKAEMED----LVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553

Query: 1021 QSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKA 1080
            Q +  ++     +  K  LE+  Q L  + E    +++A  +  EE R Q Q  L +++ 
Sbjct: 1554 QLEELEDELQATEDAKLRLEVNMQALKGQFE---RDLQARDEQNEEKRRQLQRQLHEYET 1610

Query: 1081 LAQLQRRQEAELEGLLVRHRDLKANMRALEL-AHRELQGRHE------QLQAQRASVEAQ 1133
              + +R+Q A         + L+ +++ LEL A   ++GR E      +LQAQ    + +
Sbjct: 1611 ELEDERKQRALAAAA---KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667

Query: 1134 EVALLAERERLM----QDGHRQRGLEEELRRLQSE-------HDRAQMLLAELSRE---- 1178
                 A R+ +     ++  + + LE +L +LQ +         +A +   EL+ E    
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1727

Query: 1179 ---RGELQGERGELRGRLARLELE----RAQLEMQSQQLRESNQQLDLSACRLTTQCELL 1231
               R  LQ E+  L  R+A+LE E    +  +E  S ++R++ QQ +          EL 
Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE------QLSNELA 1781

Query: 1232 TQLRSAQEEENRQLLAEVQALSRENREL------LERSLESR----------------DH 1269
            T+  +AQ+ E+ +     Q L R+N+EL      +E +++S+                + 
Sbjct: 1782 TERSTAQKNESAR-----QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1836

Query: 1270 LHREQREYLDQLNALRREKQKLVE---KIMDQYRVLEPVPLPRTKKGSWLADKVKRLMRP 1326
            + +E RE      +L+++ +KL E   ++ D+ ++ E     + +KG+    ++KR +  
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK-EQAEKGNARVKQLKRQLEE 1895

Query: 1327 RREGGPPGGLRLGADGAGSTESLGGPPETELPEGREADGTGSP--SPAPMRRAQ 1378
              E       R+ A+       L    E+    GRE +   S    P P   +Q
Sbjct: 1896 AEEESQ----RINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQETSQ 1945



 Score =  119 bits (299), Expect = 2e-26
 Identities = 228/1060 (21%), Positives = 424/1060 (40%), Gaps = 174/1060 (16%)

Query: 213  LSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQ 272
            L+KL  + +     L E+ L++E    +     +   EG +     Q+A+ +AQ+  L+ 
Sbjct: 1032 LTKLKNKHESMISEL-EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090

Query: 273  ELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRL 332
            +L +K E           L+A + RL  E    +   K+          +RE  G +  L
Sbjct: 1091 QLAKKEE----------ELQAALARLDDEIAQKNNALKK----------IRELEGHISDL 1130

Query: 333  QEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENL 392
            QE+L   R     AE  K  L EE      LEA K  LE+ L++   +     + ++E  
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEE------LEALKTELEDTLDSTATQQELRAKREQEVT 1184

Query: 393  LLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDE 452
            +L+  L E   E  S   QV ++ +++ +   EL   LE                    +
Sbjct: 1185 VLKKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLE--------------------Q 1221

Query: 453  VREAEAG---RLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPV 509
             + A+A      +TLE+EN +L G L+VL GQ                    +E      
Sbjct: 1222 FKRAKANLDKNKQTLEKENADLAGELRVL-GQ------------------AKQEVEHKKK 1262

Query: 510  AFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDP 569
              +   Q L  K  DG     +L         E  +      +++ +  +     A++  
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322

Query: 570  QASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREA 629
            Q  D           TQE  ++  R+                 K+     L    E R +
Sbjct: 1323 QLQD-----------TQELLQEETRQ-----------------KLNVSTKLRQLEEERNS 1354

Query: 630  PQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGT 689
             Q +L  E      E  ++        ++QL + +   Q  D A+      E  +R +  
Sbjct: 1355 LQDQLDEE-----MEAKQNLERHISTLNIQLSDSKKKLQ--DFASTVEALEEGKKRFQKE 1407

Query: 690  VRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELE 749
            + +   Q+ ++K+    +++  +  +  E L   V + +  R+ V+ L +K         
Sbjct: 1408 IEN-LTQQYEEKAAAYDKLEKTKNRLQQE-LDDLVVDLDNQRQLVSNLEKK--------- 1456

Query: 750  AQARKLEAQNTEAARLSKELAQAR-RAEAEAHREAEAQAWEQARLREAVEAAGQELESAS 808
               RK +    E   +S + A  R RAEAEA RE E +A   AR  E    A +ELE  +
Sbjct: 1457 --QRKFDQLLAEEKNISSKYADERDRAEAEA-REKETKALSLARALEEALEAKEELERTN 1513

Query: 809  Q----EREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERER 864
            +    E E LV +    G+   + E+    L  Q E  + +++ LE E +   +   R  
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573

Query: 865  REKEALQAELEKAV-VRGKELGARLEHLQRELEQAALERQEFLREK---ESQHQRYQGLE 920
               +AL+ + E+ +  R ++   +   LQR+L +   E ++  +++    +  ++ +G  
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1633

Query: 921  QRLEAELQAAATSKEEALMELKTRALQLEE---ELFQLRQGPAGLGPKKRAEPQLVETQN 977
            + LE +  +A   +EEA+ +L+    Q+++   EL   R     +    +   +  ++  
Sbjct: 1634 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693

Query: 978  VRLIEVERSNAMLVAEKAALQGQLQH---LEGQLGSLQGRAQELLLQSQRAQEHSSRLQA 1034
              L++++    +  AE+A  Q  L+     E    SL GR           Q+   RL+A
Sbjct: 1694 ADLMQLQED--LAAAERARKQADLEKEELAEELASSLSGR--------NALQDEKRRLEA 1743

Query: 1035 EKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEG 1094
              + LE + +E    +E + + VR A Q  E+   +    L   ++ AQ       +LE 
Sbjct: 1744 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE----LATERSTAQKNESARQQLER 1799

Query: 1095 LLVRHRDLKANMRALELAHR-ELQGRHEQLQAQRASVEAQEVALLAERERLMQD-GHRQR 1152
               ++++L++ +  +E A + + +     L+A+ A +E Q      E++   +    + +
Sbjct: 1800 ---QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856

Query: 1153 GLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRE 1212
             L+E L +++ E   A         E+ + Q E+G  R +  + +LE A  E +SQ++  
Sbjct: 1857 KLKEILLQVEDERKMA---------EQYKEQAEKGNARVKQLKRQLEEA--EEESQRINA 1905

Query: 1213 SNQQLDLSACRLTTQCE--------LLTQLRSAQEEENRQ 1244
            + ++L       T   E        L ++LR    +E  Q
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQETSQ 1945



 Score =  105 bits (262), Expect = 3e-22
 Identities = 158/718 (22%), Positives = 295/718 (41%), Gaps = 44/718 (6%)

Query: 612  TKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLD 671
            TK++    +  + E  +A + EL  +    RQ+  E++    E    QL E++   Q   
Sbjct: 846  TKVKPLLQVTRQEEEMQAKEDEL--QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 903

Query: 672  LATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGP-IPGE---------SLA 721
             A  +  A   + R+    +    ++   + E  LE +   G  +  E          L 
Sbjct: 904  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963

Query: 722  SGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHR 781
              + E+EA R+++   +  AEA   +LE +   ++ QN + ++  K L +          
Sbjct: 964  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023

Query: 782  EAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQ--- 838
            E E +A    +L+   E+   ELE   ++ E   + L    + +R+ E + S    Q   
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE---KLKRKLEGDASDFHEQIAD 1080

Query: 839  --SEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELE 896
              ++ AE +MQ+ + E     EE +      +   A+   A+ + +EL   +  LQ +L+
Sbjct: 1081 LQAQIAELKMQLAKKE-----EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135

Query: 897  QAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKE-EALMELKTRALQ--LEEELF 953
                 R +  ++K    +  + L+  LE  L + AT +E  A  E +   L+  L+EE  
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET- 1194

Query: 954  QLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQG 1013
              R   A +   ++   Q VE    +L + +R+ A L   K  L+ +   L G+L  L  
Sbjct: 1195 --RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252

Query: 1014 RAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQA 1073
              QE+  + ++ +     LQ++ S  E    EL+ K+  L+ EV +      E  G+   
Sbjct: 1253 AKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1312

Query: 1074 LLRDHKAL-AQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGR-HEQLQAQR---A 1128
            L +D  +L +QLQ  QE  L+    +  ++   +R LE     LQ +  E+++A++    
Sbjct: 1313 LAKDVASLSSQLQDTQEL-LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371

Query: 1129 SVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGE 1188
             +    + L   +++L         LEE  +R Q E +       E +    +L+  +  
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431

Query: 1189 LRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAE 1248
            L+  L  L ++          L +  ++ D                R   E E R+   +
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491

Query: 1249 VQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQ---KLVEKIMDQYRVLE 1303
              +L+R     LE +LE+++ L R  +    ++  L   K    K V ++    R LE
Sbjct: 1492 ALSLAR----ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1545


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  141 bits (356), Expect = 4e-33
 Identities = 266/1194 (22%), Positives = 490/1194 (41%), Gaps = 173/1194 (14%)

Query: 258  LQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAK-RAELYR 316
            LQ+   + +++    EL++  E    ++ E++ LE +  +L +E   L  Q +   ELY 
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904

Query: 317  EEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKAL-LEEQLE 375
            E  E     A +   L+E L     RL+  E    QL+ ER       A + L LEEQLE
Sbjct: 905  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM----AQQMLDLEEQLE 960

Query: 376  AARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPG 435
               E  AR  + Q E +    ++ +   E+  +  Q ++L++E   LE   +R  +    
Sbjct: 961  --EEEAAR-QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE---ERISDLTTN 1014

Query: 436  SPGEAPLAGAAPSLQDE----VREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPL--- 488
               E   A     L+++    + E E  RL+  E+  +EL  L + L+G     H     
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEV-RLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073

Query: 489  LEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECP 548
            L+A   +  + + ++  +   A       + QK              AL  + E      
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN------------ALKKIRELEGHI- 1120

Query: 549  QAPDSDPQEAESPLQAAA--MDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAP 606
                SD QE     +AA    + Q  D   +      E +++ +    +  L+     A 
Sbjct: 1121 ----SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR-----AK 1171

Query: 607  PQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGP 666
             +   T ++  + L  ET   EA   E+       RQ+  +      E  + QLE+ +  
Sbjct: 1172 REQEVTVLK--KALDEETRSHEAQVQEM-------RQKHAQ----AVEELTEQLEQFKRA 1218

Query: 667  NQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAE 726
               LD      E    D   E  V   A Q+ + K +  LE QV E       L S  ++
Sbjct: 1219 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK-KLEAQVQE-------LQSKCSD 1270

Query: 727  QEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQ 786
             E  R   A+L  K   L +E+E+    L     +A +L+K++A      +   ++ +  
Sbjct: 1271 GERAR---AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL----SSQLQDTQEL 1323

Query: 787  AWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERM 846
              E+ R +  V    ++LE   +ER +L + L      ++  ER  S L  Q   +++++
Sbjct: 1324 LQEETRQKLNVSTKLRQLE---EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380

Query: 847  QVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALE---RQ 903
            Q   S      E  +R ++E E L  + E+      +L      LQ+EL+   ++   ++
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1440

Query: 904  EFLREKESQHQRYQGL---EQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPA 960
            + +   E + +++  L   E+ + ++        E    E +T+AL L   L +  +   
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE--- 1497

Query: 961  GLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLL 1020
                   A+ +L  T  +   E+E     LV+ K  +   +  LE    +L+ + +E+  
Sbjct: 1498 -------AKEELERTNKMLKAEMED----LVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546

Query: 1021 QSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKA 1080
            Q +  ++     +  K  LE+  Q L  + E    +++A  +  EE R Q Q  L +++ 
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQALKGQFE---RDLQARDEQNEEKRRQLQRQLHEYET 1603

Query: 1081 LAQLQRRQEAELEGLLVRHRDLKANMRALEL-AHRELQGRHE------QLQAQRASVEAQ 1133
              + +R+Q A         + L+ +++ LEL A   ++GR E      +LQAQ    + +
Sbjct: 1604 ELEDERKQRALAAAA---KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660

Query: 1134 EVALLAERERLM----QDGHRQRGLEEELRRLQSE-------HDRAQMLLAELSRE---- 1178
                 A R+ +     ++  + + LE +L +LQ +         +A +   EL+ E    
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1720

Query: 1179 ---RGELQGERGELRGRLARLELE----RAQLEMQSQQLRESNQQLDLSACRLTTQCELL 1231
               R  LQ E+  L  R+A+LE E    +  +E  S ++R++ QQ +          EL 
Sbjct: 1721 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE------QLSNELA 1774

Query: 1232 TQLRSAQEEENRQLLAEVQALSRENREL------LERSLESR----------------DH 1269
            T+  +AQ+ E+ +     Q L R+N+EL      +E +++S+                + 
Sbjct: 1775 TERSTAQKNESAR-----QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1829

Query: 1270 LHREQREYLDQLNALRREKQKLVE---KIMDQYRVLEPVPLPRTKKGSWLADKVKRLMRP 1326
            + +E RE      +L+++ +KL E   ++ D+ ++ E     + +KG+    ++KR +  
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK-EQAEKGNARVKQLKRQLEE 1888

Query: 1327 RREGGPPGGLRLGADGAGSTESLGGPPETELPEGREADGTGSP--SPAPMRRAQ 1378
              E       R+ A+       L    E+    GRE +   S    P P   +Q
Sbjct: 1889 AEEESQ----RINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQETSQ 1938



 Score =  119 bits (299), Expect = 2e-26
 Identities = 228/1060 (21%), Positives = 424/1060 (40%), Gaps = 174/1060 (16%)

Query: 213  LSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQ 272
            L+KL  + +     L E+ L++E    +     +   EG +     Q+A+ +AQ+  L+ 
Sbjct: 1025 LTKLKNKHESMISEL-EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083

Query: 273  ELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRL 332
            +L +K E           L+A + RL  E    +   K+          +RE  G +  L
Sbjct: 1084 QLAKKEE----------ELQAALARLDDEIAQKNNALKK----------IRELEGHISDL 1123

Query: 333  QEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENL 392
            QE+L   R     AE  K  L EE      LEA K  LE+ L++   +     + ++E  
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEE------LEALKTELEDTLDSTATQQELRAKREQEVT 1177

Query: 393  LLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDE 452
            +L+  L E   E  S   QV ++ +++ +   EL   LE                    +
Sbjct: 1178 VLKKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLE--------------------Q 1214

Query: 453  VREAEAG---RLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPV 509
             + A+A      +TLE+EN +L G L+VL GQ                    +E      
Sbjct: 1215 FKRAKANLDKNKQTLEKENADLAGELRVL-GQ------------------AKQEVEHKKK 1255

Query: 510  AFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDP 569
              +   Q L  K  DG     +L         E  +      +++ +  +     A++  
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315

Query: 570  QASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREA 629
            Q  D           TQE  ++  R+                 K+     L    E R +
Sbjct: 1316 QLQD-----------TQELLQEETRQ-----------------KLNVSTKLRQLEEERNS 1347

Query: 630  PQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGT 689
             Q +L  E      E  ++        ++QL + +   Q  D A+      E  +R +  
Sbjct: 1348 LQDQLDEE-----MEAKQNLERHISTLNIQLSDSKKKLQ--DFASTVEALEEGKKRFQKE 1400

Query: 690  VRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELE 749
            + +   Q+ ++K+    +++  +  +  E L   V + +  R+ V+ L +K         
Sbjct: 1401 IEN-LTQQYEEKAAAYDKLEKTKNRLQQE-LDDLVVDLDNQRQLVSNLEKK--------- 1449

Query: 750  AQARKLEAQNTEAARLSKELAQAR-RAEAEAHREAEAQAWEQARLREAVEAAGQELESAS 808
               RK +    E   +S + A  R RAEAEA RE E +A   AR  E    A +ELE  +
Sbjct: 1450 --QRKFDQLLAEEKNISSKYADERDRAEAEA-REKETKALSLARALEEALEAKEELERTN 1506

Query: 809  Q----EREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERER 864
            +    E E LV +    G+   + E+    L  Q E  + +++ LE E +   +   R  
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566

Query: 865  REKEALQAELEKAV-VRGKELGARLEHLQRELEQAALERQEFLREK---ESQHQRYQGLE 920
               +AL+ + E+ +  R ++   +   LQR+L +   E ++  +++    +  ++ +G  
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1626

Query: 921  QRLEAELQAAATSKEEALMELKTRALQLEE---ELFQLRQGPAGLGPKKRAEPQLVETQN 977
            + LE +  +A   +EEA+ +L+    Q+++   EL   R     +    +   +  ++  
Sbjct: 1627 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1686

Query: 978  VRLIEVERSNAMLVAEKAALQGQLQH---LEGQLGSLQGRAQELLLQSQRAQEHSSRLQA 1034
              L++++    +  AE+A  Q  L+     E    SL GR           Q+   RL+A
Sbjct: 1687 ADLMQLQED--LAAAERARKQADLEKEELAEELASSLSGR--------NALQDEKRRLEA 1736

Query: 1035 EKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEG 1094
              + LE + +E    +E + + VR A Q  E+   +    L   ++ AQ       +LE 
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE----LATERSTAQKNESARQQLER 1792

Query: 1095 LLVRHRDLKANMRALELAHR-ELQGRHEQLQAQRASVEAQEVALLAERERLMQD-GHRQR 1152
               ++++L++ +  +E A + + +     L+A+ A +E Q      E++   +    + +
Sbjct: 1793 ---QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849

Query: 1153 GLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRE 1212
             L+E L +++ E   A         E+ + Q E+G  R +  + +LE A  E +SQ++  
Sbjct: 1850 KLKEILLQVEDERKMA---------EQYKEQAEKGNARVKQLKRQLEEA--EEESQRINA 1898

Query: 1213 SNQQLDLSACRLTTQCE--------LLTQLRSAQEEENRQ 1244
            + ++L       T   E        L ++LR    +E  Q
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQETSQ 1938



 Score =  105 bits (262), Expect = 3e-22
 Identities = 158/718 (22%), Positives = 295/718 (41%), Gaps = 44/718 (6%)

Query: 612  TKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLD 671
            TK++    +  + E  +A + EL  +    RQ+  E++    E    QL E++   Q   
Sbjct: 839  TKVKPLLQVTRQEEEMQAKEDEL--QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 896

Query: 672  LATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGP-IPGE---------SLA 721
             A  +  A   + R+    +    ++   + E  LE +   G  +  E          L 
Sbjct: 897  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956

Query: 722  SGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHR 781
              + E+EA R+++   +  AEA   +LE +   ++ QN + ++  K L +          
Sbjct: 957  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016

Query: 782  EAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQ--- 838
            E E +A    +L+   E+   ELE   ++ E   + L    + +R+ E + S    Q   
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE---KLKRKLEGDASDFHEQIAD 1073

Query: 839  --SEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELE 896
              ++ AE +MQ+ + E     EE +      +   A+   A+ + +EL   +  LQ +L+
Sbjct: 1074 LQAQIAELKMQLAKKE-----EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128

Query: 897  QAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKE-EALMELKTRALQ--LEEELF 953
                 R +  ++K    +  + L+  LE  L + AT +E  A  E +   L+  L+EE  
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET- 1187

Query: 954  QLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQG 1013
              R   A +   ++   Q VE    +L + +R+ A L   K  L+ +   L G+L  L  
Sbjct: 1188 --RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245

Query: 1014 RAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQA 1073
              QE+  + ++ +     LQ++ S  E    EL+ K+  L+ EV +      E  G+   
Sbjct: 1246 AKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1305

Query: 1074 LLRDHKAL-AQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGR-HEQLQAQR---A 1128
            L +D  +L +QLQ  QE  L+    +  ++   +R LE     LQ +  E+++A++    
Sbjct: 1306 LAKDVASLSSQLQDTQEL-LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364

Query: 1129 SVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGE 1188
             +    + L   +++L         LEE  +R Q E +       E +    +L+  +  
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424

Query: 1189 LRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAE 1248
            L+  L  L ++          L +  ++ D                R   E E R+   +
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1484

Query: 1249 VQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQ---KLVEKIMDQYRVLE 1303
              +L+R     LE +LE+++ L R  +    ++  L   K    K V ++    R LE
Sbjct: 1485 ALSLAR----ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1538


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  140 bits (352), Expect = 1e-32
 Identities = 263/1182 (22%), Positives = 486/1182 (41%), Gaps = 171/1182 (14%)

Query: 258  LQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAK-RAELYR 316
            LQ+   + +++    EL++  E    ++ E++ LE +  +L +E   L  Q +   ELY 
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904

Query: 317  EEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKAL-LEEQLE 375
            E  E     A +   L+E L     RL+  E    QL+ ER       A + L LEEQLE
Sbjct: 905  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM----AQQMLDLEEQLE 960

Query: 376  AARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPG 435
               E  AR  + Q E +    ++ +   E+  +  Q ++L++E   LE   +R  +    
Sbjct: 961  --EEEAAR-QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE---ERISDLTTN 1014

Query: 436  SPGEAPLAGAAPSLQDE----VREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPL--- 488
               E   A     L+++    + E E  RL+  E+  +EL  L + L+G     H     
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEV-RLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073

Query: 489  LEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECP 548
            L+A   +  + + ++  +   A       + QK              AL  + E      
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN------------ALKKIRELEGHI- 1120

Query: 549  QAPDSDPQEAESPLQAAA--MDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAP 606
                SD QE     +AA    + Q  D   +      E +++ +    +  L+     A 
Sbjct: 1121 ----SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR-----AK 1171

Query: 607  PQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGP 666
             +   T ++  + L  ET   EA   E+       RQ+  +      E  + QLE+ +  
Sbjct: 1172 REQEVTVLK--KALDEETRSHEAQVQEM-------RQKHAQ----AVEELTEQLEQFKRA 1218

Query: 667  NQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAE 726
               LD      E    D   E  V   A Q+ + K +  LE QV E       L S  ++
Sbjct: 1219 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK-KLEAQVQE-------LQSKCSD 1270

Query: 727  QEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQ 786
             E  R   A+L  K   L +E+E+    L     +A +L+K++A      +   ++ +  
Sbjct: 1271 GERAR---AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL----SSQLQDTQEL 1323

Query: 787  AWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERM 846
              E+ R +  V    ++LE   +ER +L + L      ++  ER  S L  Q   +++++
Sbjct: 1324 LQEETRQKLNVSTKLRQLE---EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380

Query: 847  QVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALE---RQ 903
            Q   S      E  +R ++E E L  + E+      +L      LQ+EL+   ++   ++
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1440

Query: 904  EFLREKESQHQRYQGL---EQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPA 960
            + +   E + +++  L   E+ + ++        E    E +T+AL L   L +  +   
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE--- 1497

Query: 961  GLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLL 1020
                   A+ +L  T  +   E+E     LV+ K  +   +  LE    +L+ + +E+  
Sbjct: 1498 -------AKEELERTNKMLKAEMED----LVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546

Query: 1021 QSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKA 1080
            Q +  ++     +  K  LE+  Q L  + E    +++A  +  EE R Q Q  L +++ 
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQALKGQFE---RDLQARDEQNEEKRRQLQRQLHEYET 1603

Query: 1081 LAQLQRRQEAELEGLLVRHRDLKANMRALEL-AHRELQGRHE------QLQAQRASVEAQ 1133
              + +R+Q A         + L+ +++ LEL A   ++GR E      +LQAQ    + +
Sbjct: 1604 ELEDERKQRALAAAA---KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660

Query: 1134 EVALLAERERLM----QDGHRQRGLEEELRRLQSE-------HDRAQMLLAELSRE---- 1178
                 A R+ +     ++  + + LE +L +LQ +         +A +   EL+ E    
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1720

Query: 1179 ---RGELQGERGELRGRLARLELE----RAQLEMQSQQLRESNQQLDLSACRLTTQCELL 1231
               R  LQ E+  L  R+A+LE E    +  +E  S ++R++ QQ +          EL 
Sbjct: 1721 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE------QLSNELA 1774

Query: 1232 TQLRSAQEEENRQLLAEVQALSRENREL------LERSLESR----------------DH 1269
            T+  +AQ+ E+ +     Q L R+N+EL      +E +++S+                + 
Sbjct: 1775 TERSTAQKNESAR-----QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1829

Query: 1270 LHREQREYLDQLNALRREKQKLVE---KIMDQYRVLEPVPLPRTKKGSWLADKVKRLMRP 1326
            + +E RE      +L+++ +KL E   ++ D+ ++ E     + +KG+    ++KR +  
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK-EQAEKGNARVKQLKRQLEE 1888

Query: 1327 RREGGPPGGLRLGADGAGSTESLGGPPETELPEGREADGTGS 1368
              E       R+ A+       L    E+    GRE +   S
Sbjct: 1889 AEEESQ----RINANRRKLQRELDEATESNEAMGREVNALKS 1926



 Score =  119 bits (299), Expect = 2e-26
 Identities = 225/1052 (21%), Positives = 424/1052 (40%), Gaps = 166/1052 (15%)

Query: 213  LSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQ 272
            L+KL  + +     L E+ L++E    +     +   EG +     Q+A+ +AQ+  L+ 
Sbjct: 1025 LTKLKNKHESMISEL-EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083

Query: 273  ELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRL 332
            +L +K E           L+A + RL  E    +   K+          +RE  G +  L
Sbjct: 1084 QLAKKEE----------ELQAALARLDDEIAQKNNALKK----------IRELEGHISDL 1123

Query: 333  QEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENL 392
            QE+L   R     AE  K  L EE      LEA K  LE+ L++   +     + ++E  
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEE------LEALKTELEDTLDSTATQQELRAKREQEVT 1177

Query: 393  LLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDE 452
            +L+  L E   E  S   QV ++ +++ +   EL   LE                    +
Sbjct: 1178 VLKKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLE--------------------Q 1214

Query: 453  VREAEAG---RLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPV 509
             + A+A      +TLE+EN +L G L+VL GQ                    +E      
Sbjct: 1215 FKRAKANLDKNKQTLEKENADLAGELRVL-GQ------------------AKQEVEHKKK 1255

Query: 510  AFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDP 569
              +   Q L  K  DG     +L         E  +      +++ +  +     A++  
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315

Query: 570  QASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREA 629
            Q  D           TQE  ++  R+                 K+     L    E R +
Sbjct: 1316 QLQD-----------TQELLQEETRQ-----------------KLNVSTKLRQLEEERNS 1347

Query: 630  PQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGT 689
             Q +L  E      E  ++        ++QL + +   Q  D A+      E  +R +  
Sbjct: 1348 LQDQLDEE-----MEAKQNLERHISTLNIQLSDSKKKLQ--DFASTVEALEEGKKRFQKE 1400

Query: 690  VRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELE 749
            + +   Q+ ++K+    +++  +  +  E L   V + +  R+ V+ L +K         
Sbjct: 1401 IEN-LTQQYEEKAAAYDKLEKTKNRLQQE-LDDLVVDLDNQRQLVSNLEKK--------- 1449

Query: 750  AQARKLEAQNTEAARLSKELAQAR-RAEAEAHREAEAQAWEQARLREAVEAAGQELESAS 808
               RK +    E   +S + A  R RAEAEA RE E +A   AR  E    A +ELE  +
Sbjct: 1450 --QRKFDQLLAEEKNISSKYADERDRAEAEA-REKETKALSLARALEEALEAKEELERTN 1506

Query: 809  Q----EREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERER 864
            +    E E LV +    G+   + E+    L  Q E  + +++ LE E +   +   R  
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566

Query: 865  REKEALQAELEKAV-VRGKELGARLEHLQRELEQAALERQEFLREK---ESQHQRYQGLE 920
               +AL+ + E+ +  R ++   +   LQR+L +   E ++  +++    +  ++ +G  
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1626

Query: 921  QRLEAELQAAATSKEEALMELKTRALQLEE---ELFQLRQGPAGLGPKKRAEPQLVETQN 977
            + LE +  +A   +EEA+ +L+    Q+++   EL   R     +    +   +  ++  
Sbjct: 1627 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1686

Query: 978  VRLIEVERSNAMLVAEKAALQGQLQH---LEGQLGSLQGRAQELLLQSQRAQEHSSRLQA 1034
              L++++    +  AE+A  Q  L+     E    SL GR           Q+   RL+A
Sbjct: 1687 ADLMQLQED--LAAAERARKQADLEKEELAEELASSLSGR--------NALQDEKRRLEA 1736

Query: 1035 EKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEG 1094
              + LE + +E    +E + + VR A Q  E+   +    L   ++ AQ       +LE 
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE----LATERSTAQKNESARQQLER 1792

Query: 1095 LLVRHRDLKANMRALELAHR-ELQGRHEQLQAQRASVEAQEVALLAERERLMQD-GHRQR 1152
               ++++L++ +  +E A + + +     L+A+ A +E Q      E++   +    + +
Sbjct: 1793 ---QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849

Query: 1153 GLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRE 1212
             L+E L +++ E   A         E+ + Q E+G  R +  + +LE A  E +SQ++  
Sbjct: 1850 KLKEILLQVEDERKMA---------EQYKEQAEKGNARVKQLKRQLEEA--EEESQRINA 1898

Query: 1213 SNQQLDLSACRLTTQCELLTQLRSAQEEENRQ 1244
            + ++L       T   E + +  +A + + R+
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKLRR 1930



 Score =  105 bits (262), Expect = 3e-22
 Identities = 158/718 (22%), Positives = 295/718 (41%), Gaps = 44/718 (6%)

Query: 612  TKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLD 671
            TK++    +  + E  +A + EL  +    RQ+  E++    E    QL E++   Q   
Sbjct: 839  TKVKPLLQVTRQEEEMQAKEDEL--QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 896

Query: 672  LATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGP-IPGE---------SLA 721
             A  +  A   + R+    +    ++   + E  LE +   G  +  E          L 
Sbjct: 897  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956

Query: 722  SGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHR 781
              + E+EA R+++   +  AEA   +LE +   ++ QN + ++  K L +          
Sbjct: 957  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016

Query: 782  EAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQ--- 838
            E E +A    +L+   E+   ELE   ++ E   + L    + +R+ E + S    Q   
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE---KLKRKLEGDASDFHEQIAD 1073

Query: 839  --SEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELE 896
              ++ AE +MQ+ + E     EE +      +   A+   A+ + +EL   +  LQ +L+
Sbjct: 1074 LQAQIAELKMQLAKKE-----EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128

Query: 897  QAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKE-EALMELKTRALQ--LEEELF 953
                 R +  ++K    +  + L+  LE  L + AT +E  A  E +   L+  L+EE  
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET- 1187

Query: 954  QLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQG 1013
              R   A +   ++   Q VE    +L + +R+ A L   K  L+ +   L G+L  L  
Sbjct: 1188 --RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245

Query: 1014 RAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQA 1073
              QE+  + ++ +     LQ++ S  E    EL+ K+  L+ EV +      E  G+   
Sbjct: 1246 AKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1305

Query: 1074 LLRDHKAL-AQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGR-HEQLQAQR---A 1128
            L +D  +L +QLQ  QE  L+    +  ++   +R LE     LQ +  E+++A++    
Sbjct: 1306 LAKDVASLSSQLQDTQEL-LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364

Query: 1129 SVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGE 1188
             +    + L   +++L         LEE  +R Q E +       E +    +L+  +  
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424

Query: 1189 LRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAE 1248
            L+  L  L ++          L +  ++ D                R   E E R+   +
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1484

Query: 1249 VQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQ---KLVEKIMDQYRVLE 1303
              +L+R     LE +LE+++ L R  +    ++  L   K    K V ++    R LE
Sbjct: 1485 ALSLAR----ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1538


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  140 bits (352), Expect = 1e-32
 Identities = 263/1182 (22%), Positives = 486/1182 (41%), Gaps = 171/1182 (14%)

Query: 258  LQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAK-RAELYR 316
            LQ+   + +++    EL++  E    ++ E++ LE +  +L +E   L  Q +   ELY 
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 317  EEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKAL-LEEQLE 375
            E  E     A +   L+E L     RL+  E    QL+ ER       A + L LEEQLE
Sbjct: 912  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM----AQQMLDLEEQLE 967

Query: 376  AARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPG 435
               E  AR  + Q E +    ++ +   E+  +  Q ++L++E   LE   +R  +    
Sbjct: 968  --EEEAAR-QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE---ERISDLTTN 1021

Query: 436  SPGEAPLAGAAPSLQDE----VREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPL--- 488
               E   A     L+++    + E E  RL+  E+  +EL  L + L+G     H     
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEV-RLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080

Query: 489  LEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECP 548
            L+A   +  + + ++  +   A       + QK              AL  + E      
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN------------ALKKIRELEGHI- 1127

Query: 549  QAPDSDPQEAESPLQAAA--MDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAP 606
                SD QE     +AA    + Q  D   +      E +++ +    +  L+     A 
Sbjct: 1128 ----SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR-----AK 1178

Query: 607  PQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGP 666
             +   T ++  + L  ET   EA   E+       RQ+  +      E  + QLE+ +  
Sbjct: 1179 REQEVTVLK--KALDEETRSHEAQVQEM-------RQKHAQ----AVEELTEQLEQFKRA 1225

Query: 667  NQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAE 726
               LD      E    D   E  V   A Q+ + K +  LE QV E       L S  ++
Sbjct: 1226 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK-KLEAQVQE-------LQSKCSD 1277

Query: 727  QEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQ 786
             E  R   A+L  K   L +E+E+    L     +A +L+K++A      +   ++ +  
Sbjct: 1278 GERAR---AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL----SSQLQDTQEL 1330

Query: 787  AWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERM 846
              E+ R +  V    ++LE   +ER +L + L      ++  ER  S L  Q   +++++
Sbjct: 1331 LQEETRQKLNVSTKLRQLE---EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387

Query: 847  QVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALE---RQ 903
            Q   S      E  +R ++E E L  + E+      +L      LQ+EL+   ++   ++
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1447

Query: 904  EFLREKESQHQRYQGL---EQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPA 960
            + +   E + +++  L   E+ + ++        E    E +T+AL L   L +  +   
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE--- 1504

Query: 961  GLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLL 1020
                   A+ +L  T  +   E+E     LV+ K  +   +  LE    +L+ + +E+  
Sbjct: 1505 -------AKEELERTNKMLKAEMED----LVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553

Query: 1021 QSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKA 1080
            Q +  ++     +  K  LE+  Q L  + E    +++A  +  EE R Q Q  L +++ 
Sbjct: 1554 QLEELEDELQATEDAKLRLEVNMQALKGQFE---RDLQARDEQNEEKRRQLQRQLHEYET 1610

Query: 1081 LAQLQRRQEAELEGLLVRHRDLKANMRALEL-AHRELQGRHE------QLQAQRASVEAQ 1133
              + +R+Q A         + L+ +++ LEL A   ++GR E      +LQAQ    + +
Sbjct: 1611 ELEDERKQRALAAAA---KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667

Query: 1134 EVALLAERERLM----QDGHRQRGLEEELRRLQSE-------HDRAQMLLAELSRE---- 1178
                 A R+ +     ++  + + LE +L +LQ +         +A +   EL+ E    
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1727

Query: 1179 ---RGELQGERGELRGRLARLELE----RAQLEMQSQQLRESNQQLDLSACRLTTQCELL 1231
               R  LQ E+  L  R+A+LE E    +  +E  S ++R++ QQ +          EL 
Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE------QLSNELA 1781

Query: 1232 TQLRSAQEEENRQLLAEVQALSRENREL------LERSLESR----------------DH 1269
            T+  +AQ+ E+ +     Q L R+N+EL      +E +++S+                + 
Sbjct: 1782 TERSTAQKNESAR-----QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1836

Query: 1270 LHREQREYLDQLNALRREKQKLVE---KIMDQYRVLEPVPLPRTKKGSWLADKVKRLMRP 1326
            + +E RE      +L+++ +KL E   ++ D+ ++ E     + +KG+    ++KR +  
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK-EQAEKGNARVKQLKRQLEE 1895

Query: 1327 RREGGPPGGLRLGADGAGSTESLGGPPETELPEGREADGTGS 1368
              E       R+ A+       L    E+    GRE +   S
Sbjct: 1896 AEEESQ----RINANRRKLQRELDEATESNEAMGREVNALKS 1933



 Score =  119 bits (299), Expect = 2e-26
 Identities = 225/1052 (21%), Positives = 424/1052 (40%), Gaps = 166/1052 (15%)

Query: 213  LSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQ 272
            L+KL  + +     L E+ L++E    +     +   EG +     Q+A+ +AQ+  L+ 
Sbjct: 1032 LTKLKNKHESMISEL-EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090

Query: 273  ELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRL 332
            +L +K E           L+A + RL  E    +   K+          +RE  G +  L
Sbjct: 1091 QLAKKEE----------ELQAALARLDDEIAQKNNALKK----------IRELEGHISDL 1130

Query: 333  QEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENL 392
            QE+L   R     AE  K  L EE      LEA K  LE+ L++   +     + ++E  
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEE------LEALKTELEDTLDSTATQQELRAKREQEVT 1184

Query: 393  LLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDE 452
            +L+  L E   E  S   QV ++ +++ +   EL   LE                    +
Sbjct: 1185 VLKKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLE--------------------Q 1221

Query: 453  VREAEAG---RLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPV 509
             + A+A      +TLE+EN +L G L+VL GQ                    +E      
Sbjct: 1222 FKRAKANLDKNKQTLEKENADLAGELRVL-GQ------------------AKQEVEHKKK 1262

Query: 510  AFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDP 569
              +   Q L  K  DG     +L         E  +      +++ +  +     A++  
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322

Query: 570  QASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREA 629
            Q  D           TQE  ++  R+                 K+     L    E R +
Sbjct: 1323 QLQD-----------TQELLQEETRQ-----------------KLNVSTKLRQLEEERNS 1354

Query: 630  PQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGT 689
             Q +L  E      E  ++        ++QL + +   Q  D A+      E  +R +  
Sbjct: 1355 LQDQLDEE-----MEAKQNLERHISTLNIQLSDSKKKLQ--DFASTVEALEEGKKRFQKE 1407

Query: 690  VRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELE 749
            + +   Q+ ++K+    +++  +  +  E L   V + +  R+ V+ L +K         
Sbjct: 1408 IEN-LTQQYEEKAAAYDKLEKTKNRLQQE-LDDLVVDLDNQRQLVSNLEKK--------- 1456

Query: 750  AQARKLEAQNTEAARLSKELAQAR-RAEAEAHREAEAQAWEQARLREAVEAAGQELESAS 808
               RK +    E   +S + A  R RAEAEA RE E +A   AR  E    A +ELE  +
Sbjct: 1457 --QRKFDQLLAEEKNISSKYADERDRAEAEA-REKETKALSLARALEEALEAKEELERTN 1513

Query: 809  Q----EREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERER 864
            +    E E LV +    G+   + E+    L  Q E  + +++ LE E +   +   R  
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573

Query: 865  REKEALQAELEKAV-VRGKELGARLEHLQRELEQAALERQEFLREK---ESQHQRYQGLE 920
               +AL+ + E+ +  R ++   +   LQR+L +   E ++  +++    +  ++ +G  
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1633

Query: 921  QRLEAELQAAATSKEEALMELKTRALQLEE---ELFQLRQGPAGLGPKKRAEPQLVETQN 977
            + LE +  +A   +EEA+ +L+    Q+++   EL   R     +    +   +  ++  
Sbjct: 1634 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693

Query: 978  VRLIEVERSNAMLVAEKAALQGQLQH---LEGQLGSLQGRAQELLLQSQRAQEHSSRLQA 1034
              L++++    +  AE+A  Q  L+     E    SL GR           Q+   RL+A
Sbjct: 1694 ADLMQLQED--LAAAERARKQADLEKEELAEELASSLSGR--------NALQDEKRRLEA 1743

Query: 1035 EKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEG 1094
              + LE + +E    +E + + VR A Q  E+   +    L   ++ AQ       +LE 
Sbjct: 1744 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE----LATERSTAQKNESARQQLER 1799

Query: 1095 LLVRHRDLKANMRALELAHR-ELQGRHEQLQAQRASVEAQEVALLAERERLMQD-GHRQR 1152
               ++++L++ +  +E A + + +     L+A+ A +E Q      E++   +    + +
Sbjct: 1800 ---QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856

Query: 1153 GLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRE 1212
             L+E L +++ E   A         E+ + Q E+G  R +  + +LE A  E +SQ++  
Sbjct: 1857 KLKEILLQVEDERKMA---------EQYKEQAEKGNARVKQLKRQLEEA--EEESQRINA 1905

Query: 1213 SNQQLDLSACRLTTQCELLTQLRSAQEEENRQ 1244
            + ++L       T   E + +  +A + + R+
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKLRR 1937



 Score =  105 bits (262), Expect = 3e-22
 Identities = 158/718 (22%), Positives = 295/718 (41%), Gaps = 44/718 (6%)

Query: 612  TKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLD 671
            TK++    +  + E  +A + EL  +    RQ+  E++    E    QL E++   Q   
Sbjct: 846  TKVKPLLQVTRQEEEMQAKEDEL--QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 903

Query: 672  LATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGP-IPGE---------SLA 721
             A  +  A   + R+    +    ++   + E  LE +   G  +  E          L 
Sbjct: 904  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963

Query: 722  SGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHR 781
              + E+EA R+++   +  AEA   +LE +   ++ QN + ++  K L +          
Sbjct: 964  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023

Query: 782  EAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQ--- 838
            E E +A    +L+   E+   ELE   ++ E   + L    + +R+ E + S    Q   
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE---KLKRKLEGDASDFHEQIAD 1080

Query: 839  --SEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELE 896
              ++ AE +MQ+ + E     EE +      +   A+   A+ + +EL   +  LQ +L+
Sbjct: 1081 LQAQIAELKMQLAKKE-----EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135

Query: 897  QAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKE-EALMELKTRALQ--LEEELF 953
                 R +  ++K    +  + L+  LE  L + AT +E  A  E +   L+  L+EE  
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET- 1194

Query: 954  QLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQG 1013
              R   A +   ++   Q VE    +L + +R+ A L   K  L+ +   L G+L  L  
Sbjct: 1195 --RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252

Query: 1014 RAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQA 1073
              QE+  + ++ +     LQ++ S  E    EL+ K+  L+ EV +      E  G+   
Sbjct: 1253 AKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1312

Query: 1074 LLRDHKAL-AQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGR-HEQLQAQR---A 1128
            L +D  +L +QLQ  QE  L+    +  ++   +R LE     LQ +  E+++A++    
Sbjct: 1313 LAKDVASLSSQLQDTQEL-LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371

Query: 1129 SVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGE 1188
             +    + L   +++L         LEE  +R Q E +       E +    +L+  +  
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431

Query: 1189 LRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAE 1248
            L+  L  L ++          L +  ++ D                R   E E R+   +
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491

Query: 1249 VQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQ---KLVEKIMDQYRVLE 1303
              +L+R     LE +LE+++ L R  +    ++  L   K    K V ++    R LE
Sbjct: 1492 ALSLAR----ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1545


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score =  132 bits (333), Expect = 2e-30
 Identities = 217/874 (24%), Positives = 365/874 (41%), Gaps = 148/874 (16%)

Query: 560  SPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSS---LQSPASVAPP--------- 607
            SPL   +   Q  DW  Q    P  + + P     +S+   L+     APP         
Sbjct: 258  SPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKAT 317

Query: 608  ------QGPGT--------------KIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPE 647
                  +G                 K+Q   ++   +    A QGEL  +   L+++  E
Sbjct: 318  IYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDE 377

Query: 648  H--KPGPSEPSSV----QLEEQEGPNQGLD--LATGQAEAREHDQRLEGTVRDPAWQKPQ 699
               K    EPS V    QLEE+      L   L   + EA++ ++ L+   R     + +
Sbjct: 378  EVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKR--LLDQGE 435

Query: 700  QKSEGALEVQVWE---------GPIPG-ESLASGVAEQEALREEVAQLRRKAE------- 742
                G LE QV E         GP P  E L   + E   L EEV + +++ E       
Sbjct: 436  DLRHG-LETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRE 494

Query: 743  --------ALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLR 794
                    AL +E+ ++ +++E    +  R +++L ++ +   + H   EA   E+ ++ 
Sbjct: 495  RELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEA---ERQKMS 551

Query: 795  EAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEE----RMQVLE 850
              V    +ELE  S+E             + R  ++E  +LR + E  EE    +++VL+
Sbjct: 552  ALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQ 611

Query: 851  SEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLE-------HLQRELE-QAALER 902
             E  Q    A  + R+ E L+ EL +     KEL A  +       H  RELE Q A+ R
Sbjct: 612  RELEQARASAG-DTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLR 670

Query: 903  QEFLREKESQHQRYQ--------------GLEQRLEAELQAAATSKEEALMELKTRALQL 948
             E  R +E + Q  Q                + ++ AE +A    +  A +E   R  Q 
Sbjct: 671  VEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQE 730

Query: 949  EEELFQLR---------------QGPAGLGPKKRAEPQLVETQNVRLIEV----ERSNAM 989
            E + F+ R                G   +  + R + Q +E +  +L E     +     
Sbjct: 731  ENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGS 790

Query: 990  LVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRK 1049
            L A K AL+ +L+  +  L  L    Q L    +   +    L+  K+ LE Q + L R 
Sbjct: 791  LAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRT 850

Query: 1050 LEVLEEEVRAARQSQEETRGQQQALLRDHKA-----LAQLQRR-----QEAE-LEGLLVR 1098
            ++ L +E+    +  ++   Q QA L D+K      +A  QR+      EAE   G L R
Sbjct: 851  VDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSR 910

Query: 1099 HRDLKANMR-ALEL--AHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQ-RGL 1154
             +D    +R AL+   A R+     ++L AQR     QE      ++R   D  RQ +GL
Sbjct: 911  LQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAE---NKKRSQDDRARQLKGL 967

Query: 1155 EEELRRLQSEHDR----AQMLLAELSRERGELQGERGEL-RGRLAR--LELERAQLEMQS 1207
            EE++ RL++E D      ++L   ++R R ++   R EL + R AR  LE ++  LE Q+
Sbjct: 968  EEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQN 1027

Query: 1208 QQLR------ESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLE 1261
            + L+      E  Q+   S  +L +Q +LL +   A+E E   L +  + L R+ +EL  
Sbjct: 1028 KDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSI 1087

Query: 1262 RSLESRDHLHREQREYLDQLNALRREKQKLVEKI 1295
            +  + R H++ ++ +   ++ AL+R+  +  E+I
Sbjct: 1088 QIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEI 1121



 Score =  112 bits (280), Expect = 3e-24
 Identities = 231/961 (24%), Positives = 377/961 (39%), Gaps = 188/961 (19%)

Query: 333  QEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENL 392
            Q EL R  E LQ       +L+EE      LE S+  LE QLE   E C+RL E      
Sbjct: 361  QGELTRKVEELQR------KLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQE------ 408

Query: 393  LLRTRLGEA---HAELDSLRHQVDQLAEENVELE---LELQRSLEPPPGSPGEAPLAGAA 446
            LL  R GEA   + EL +++  +DQ  +    LE   +ELQ  L+   G     P     
Sbjct: 409  LLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQG-----PEPAKE 463

Query: 447  PSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQ 506
              L+D +             E REL  L +VL+G+   +  L    RE   L  L+ A +
Sbjct: 464  VLLKDLL-------------ETREL--LEEVLEGKQRVEEQLRLRERE---LTALKGALK 505

Query: 507  TPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAA 566
              VA           +RD                 +      Q    D ++    +Q A 
Sbjct: 506  EEVA-----------SRD-----------------QEVEHVRQQYQRDTEQLRRSMQDAT 537

Query: 567  MDPQASDWSPQESGSPV-----ETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLG 621
             D    +   Q+  + V     E +E+ E+ G   S+                       
Sbjct: 538  QDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQK-------------------- 577

Query: 622  GETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEARE 681
               E   A + EL+     LR E  E +    E   V   E E           QA A  
Sbjct: 578  -NKEDLRATKQELLQ----LRMEKEEMEEELGEKIEVLQRELE-----------QARASA 621

Query: 682  HDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKA 741
             D R    ++    +  ++  E   E Q  E         +G      L +++A LR +A
Sbjct: 622  GDTRQVEVLKKELLRTQEELKELQAERQSQE--------VAGRHRDRELEKQLAVLRVEA 673

Query: 742  EALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAG 801
            +        + R+LE QN +  +  ++L Q     ++A   AEA+A    + R AVE   
Sbjct: 674  D--------RGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTL 725

Query: 802  QELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAE 861
            +E +  + E    +  L    +E R     G  + A+     +++Q LE+E +Q LEEA 
Sbjct: 726  RETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEAR---LRDKLQRLEAE-KQQLEEAL 781

Query: 862  RERREKE--------ALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLR---EKE 910
               +E+E        AL+A LE+A      LG   + L R LE+   +R+   R   E E
Sbjct: 782  NASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELE 841

Query: 911  SQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEP 970
             Q +       RL  EL+      ++AL +L+    QLE+              K++A  
Sbjct: 842  EQKRLLDRTVDRLNKELEKIGEDSKQALQQLQA---QLEDY-------------KEKARR 885

Query: 971  QLVETQNVR---LIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQE 1027
            ++ + Q        E E+++  L    + LQ ++Q L   L + Q       L  +   +
Sbjct: 886  EVADAQRQAKDWASEAEKTSGGL----SRLQDEIQRLRQALQASQAERDTARLDKELLAQ 941

Query: 1028 HSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRR 1087
                L+ E    +    +  R+L+ LEE+V       +E +   + LL D        R 
Sbjct: 942  RLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVE-LLTDR---VNRGRD 997

Query: 1088 QEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVE-----AQEVALLAERE 1142
            Q  +L   L++ R  + +   LE     L+ +++ L+ + AS E     +  ++ L  + 
Sbjct: 998  QVDQLRTELMQERSARQD---LECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQN 1054

Query: 1143 RLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQ 1202
            +L+Q+  R +  E E   LQS + + +  + ELS    +++ ER  +  +  +L L    
Sbjct: 1055 QLLQE--RLQAEEREKTVLQSTNRKLERKVKELSI---QIEDERQHVNDQKDQLSLRVKA 1109

Query: 1203 LEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLER 1262
            L+ Q  +  E  ++LD    R   Q E+       Q E N QL A +++L +++     R
Sbjct: 1110 LKRQVDEAEEEIERLD--GLRKKAQREV-----EEQHEVNEQLQARIKSLEKDSWRKASR 1162

Query: 1263 S 1263
            S
Sbjct: 1163 S 1163



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 193/915 (21%), Positives = 362/915 (39%), Gaps = 87/915 (9%)

Query: 199  PAELEMLSRSLMGTLSKLARERDLGAQRLAELLLER-EPLCLRPEAPSRAPA-EGPSHHL 256
            P  ++ +  ++ G L + + E +   +R   L+LE+ +PL +     ++A A +G     
Sbjct: 308  PGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRK 367

Query: 257  ALQLANAKAQLRRLRQELEEKA----ELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRA 312
              +L     +  + RQ+LE         L +   E   L+  + R + EAQ  + + +  
Sbjct: 368  VEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNM 427

Query: 313  ELYREEAEALRERAG-RLPRLQEELRRCRERLQAAEAY-KSQLEEERVLSGVLEASKALL 370
            +   ++ E LR     ++  LQ +L+  +    A E   K  LE   +L  VLE  K  +
Sbjct: 428  KRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEG-KQRV 486

Query: 371  EEQLEAARERCARLHETQRENLLLRTRLGEA-----HAELDSLRHQVDQLAEENVELELE 425
            EEQL         L    +E +  R +  E        + + LR  +    +++  LE E
Sbjct: 487  EEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAE 546

Query: 426  LQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQ 485
             Q+      G   E             + +     LR  ++E  +LR   + ++ + G +
Sbjct: 547  RQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEK 606

Query: 486  HPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEAS- 544
              +L+   E       +      +  +        K      Q+ ++A    D  LE   
Sbjct: 607  IEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQL 666

Query: 545  AECPQAPDSDPQEAESPLQAA-AMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPAS 603
            A      D   +  E  LQ    +     D         V   E+     RR++++    
Sbjct: 667  AVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVE---- 722

Query: 604  VAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGP------EHKPGPSEPSS 657
                    T ++  Q    E   R     + + E  GL   G         K    E   
Sbjct: 723  --------TTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEK 774

Query: 658  VQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPA-WQKPQQKSEGALEVQVWEGPIP 716
             QLEE    +Q  + +   A+ R  + RLE   R  A   + QQ    ALE +  +  + 
Sbjct: 775  QQLEEALNASQEEEGSLAAAK-RALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVL 833

Query: 717  GESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTE-AARLSKELAQARRA 775
                A    ++  L   V +L ++ E +G++ +   ++L+AQ  +   +  +E+A A+R 
Sbjct: 834  RRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQ 893

Query: 776  EAEAHREAEAQAW-------EQARLREAVEAAGQELESASQEREALVEALAAAGRERRQW 828
              +   EAE  +        E  RLR+A++A+  E ++A  ++E L + L    +E    
Sbjct: 894  AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENK 953

Query: 829  EREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARL 888
            +R       Q +  EE++  LE+E    L+E      EK  ++  L   V RG++   ++
Sbjct: 954  KRSQDDRARQLKGLEEKVSRLETE----LDE------EKNTVEL-LTDRVNRGRD---QV 999

Query: 889  EHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEA----ELQAAATSKEEALMELKTR 944
            + L+ EL Q    RQ+   +K S  ++ + L+ RL +    +  +A+ S+ E+  +L   
Sbjct: 1000 DQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQE 1059

Query: 945  ALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHL 1004
             LQ EE                  E  ++++ N +L   ER    L  +   ++ + QH+
Sbjct: 1060 RLQAEER-----------------EKTVLQSTNRKL---ERKVKELSIQ---IEDERQHV 1096

Query: 1005 EGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQS- 1063
              Q   L  R + L  Q   A+E   RL   +   + + +E H   E L+  +++  +  
Sbjct: 1097 NDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDS 1156

Query: 1064 -QEETRGQQQALLRD 1077
             ++ +R   ++ L++
Sbjct: 1157 WRKASRSAAESALKN 1171



 Score = 77.8 bits (190), Expect = 7e-14
 Identities = 193/873 (22%), Positives = 341/873 (39%), Gaps = 127/873 (14%)

Query: 123  LGFDPLSEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPG 182
            +G +   EE  E+   +  LL     + +     +++++ L L+   +L   ++      
Sbjct: 390  VGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRL-LDQGEDLRHGLETQVMEL 448

Query: 183  AGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPL----- 237
               +  + GP+P +      E+L + L+ T  +L  E   G QR+ E L  RE       
Sbjct: 449  QNKLKHVQGPEPAK------EVLLKDLLET-RELLEEVLEGKQRVEEQLRLRERELTALK 501

Query: 238  -CLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIR 296
              L+ E  SR   +    H+  Q      QLRR  Q+  +   +L   +AE Q + A +R
Sbjct: 502  GALKEEVASR---DQEVEHVRQQYQRDTEQLRRSMQDATQDHAVL---EAERQKMSALVR 555

Query: 297  RLRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEE 356
             L++E +             E +E          + +E+LR  ++ L      K ++EEE
Sbjct: 556  GLQRELE-------------ETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEE 602

Query: 357  RVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLR--HQVDQ 414
                  L     +L+ +LE AR       + +    +L+  L     EL  L+   Q  +
Sbjct: 603  ------LGEKIEVLQRELEQARASAGDTRQVE----VLKKELLRTQEELKELQAERQSQE 652

Query: 415  LAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGL 474
            +A  + + ELE Q +                       V   EA R R LE +N +L+  
Sbjct: 653  VAGRHRDRELEKQLA-----------------------VLRVEADRGRELEEQNLQLQKT 689

Query: 475  LQVL-QGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLA 533
            LQ L Q         + A  E  VL     A +T +          ++   G  Q L   
Sbjct: 690  LQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKET 749

Query: 534  PPALDSVLEASAECP---QAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPE 590
               +D      A      Q  +++ Q+ E  L A          S +E GS         
Sbjct: 750  RGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNA----------SQEEEGS--------- 790

Query: 591  KAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKP 650
             A  + +L++    A  +G     Q  Q L    E  E  Q E++       +E      
Sbjct: 791  LAAAKRALEARLEEAQ-RGLARLGQEQQTLNRALE-EEGKQREVLRRGKAELEEQKRLLD 848

Query: 651  GPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPA-----WQKPQQKSEGA 705
               +  + +LE+  G +    L   QA+  ++ ++    V D       W    +K+ G 
Sbjct: 849  RTVDRLNKELEKI-GEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGG 907

Query: 706  LEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARL 765
            L     E     ++L +  AE++  R +   L ++ + L  E E + R  + +  +   L
Sbjct: 908  LSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGL 967

Query: 766  SKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQEL---ESASQEREALVEALAAAG 822
             +++++      E     E       R R+ V+    EL    SA Q+ E    +L    
Sbjct: 968  EEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQN 1027

Query: 823  RE--RRQWEREG--------SRLRAQSEAAEERMQVLESEGRQHLEEAER--ERREKE-A 869
            ++   R    EG        S+L +Q++  +ER+Q  E E +  L+   R  ER+ KE +
Sbjct: 1028 KDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEERE-KTVLQSTNRKLERKVKELS 1086

Query: 870  LQAELEKAVVRGK--ELGARLEHLQRELEQAALE-------RQEFLREKESQHQRYQGLE 920
            +Q E E+  V  +  +L  R++ L+R++++A  E       R++  RE E QH+  + L+
Sbjct: 1087 IQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQ 1146

Query: 921  QRLEAELQAA--ATSKEEALMELKTRALQLEEE 951
             R+++  + +    S+  A   LK   L  +EE
Sbjct: 1147 ARIKSLEKDSWRKASRSAAESALKNEGLSSDEE 1179


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  129 bits (325), Expect = 2e-29
 Identities = 237/1155 (20%), Positives = 453/1155 (39%), Gaps = 155/1155 (13%)

Query: 266  QLRRLRQELEEKAELLL---DSQAEVQG----LEAEIRRLRQEAQALSGQAKRAELYREE 318
            Q+ R  +EL+ K E LL   + Q +V+G    +E + ++L +E   L+ Q +       E
Sbjct: 846  QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905

Query: 319  AEALRER-AGRLPRLQEELRRCRERLQAAEA------------------YKSQLEEERVL 359
            AE +R R A +   L+E L     R++  E                    + QL+EE   
Sbjct: 906  AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965

Query: 360  SGVLEASKALLEEQLEAARERCARLHETQ----RENLLLRTRLGEAHAELDSLRHQVDQL 415
               L+  K   E +++   E    L +      +E  L+  R+ E  ++L     +   L
Sbjct: 966  RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025

Query: 416  A-------------EENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVRE--AEAGR 460
            A             EE ++ E + ++ LE       +  L G    LQD++ E  A+   
Sbjct: 1026 AKIRNKQEVMISDLEERLKKEEKTRQELE-----KAKRKLDGETTDLQDQIAELQAQIDE 1080

Query: 461  LR-TLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLV 519
            L+  L ++  EL+G L     +   ++  L+  RE   L       Q     + + +   
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNALKVVRE---LQAQIAELQEDFESEKASRNKA 1137

Query: 520  QKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAA-----MDPQASDW 574
            +K +    + L+     L+  L+ +A   +      QE     +A        + Q  D 
Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1197

Query: 575  SPQESGSPVETQESPEKAGR-RSSLQSPASVAPPQGP--GTKIQAPQLLGGETEGREAPQ 631
              + + +  E  E  E+A R +++L+               +++  Q +  E+E +    
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL 1257

Query: 632  GELVPEAWGLRQEGPEHKPGPSEPSSVQLEE--------QEGPNQGLDLATGQAEAREHD 683
               V E      EG   +   +E +S    E        +E   +G+  A   A      
Sbjct: 1258 DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL 1317

Query: 684  QRLEGTVRDPAWQK--------PQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVA 735
            Q  +  +++   QK          ++ + +L+ Q  E     ++L   V    AL+ ++A
Sbjct: 1318 QDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVL---ALQSQLA 1374

Query: 736  QLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLRE 795
              ++K +     +E+     +    +A  LS+ L +   A  +  +       E   L  
Sbjct: 1375 DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTV 1434

Query: 796  AVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQ 855
             ++   Q   +  ++++   + LA       ++  E  R  A++   E +   L     +
Sbjct: 1435 DLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEE 1494

Query: 856  HLEEAERERREKEALQAELEKAVVRGKELGA---RLEHLQRELEQAALERQEFLREKESQ 912
             LE  E   R+ + L+A++E  +    ++G     LE  +R LEQ   E +  L E E +
Sbjct: 1495 ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE 1554

Query: 913  HQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQL 972
             Q  +  + RLE  +QA     E    +L+TR  Q EE              KKR   + 
Sbjct: 1555 LQATEDAKLRLEVNMQAMKAQFER---DLQTRDEQNEE--------------KKRLLIKQ 1597

Query: 973  VETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRL 1032
            V      L +  +  A+ VA K  ++  L+ LE Q+ +      E++ Q ++        
Sbjct: 1598 VRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRK-------- 1649

Query: 1033 QAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAEL 1092
                  L+ Q ++  R+LE        AR S++E   Q               +  E +L
Sbjct: 1650 ------LQAQMKDYQRELE-------EARASRDEIFAQ--------------SKESEKKL 1682

Query: 1093 EGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERL-MQDGHRQ 1151
            + L      L+  + + E A R  +   ++L  +  +  + + ALL E+ RL  +    +
Sbjct: 1683 KSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLE 1742

Query: 1152 RGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLR 1211
              LEEE   ++  +DR +    ++     EL  ER   +    + +  R QLE Q+++L+
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQ----KSDNARQQLERQNKELK 1798

Query: 1212 ESNQQLDLSA-----CRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLES 1266
               Q+L+ +        ++     + QL    E+E ++  A  + + R  ++L E  ++ 
Sbjct: 1799 AKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV 1858

Query: 1267 RD-HLHREQ-REYLDQLNALRREKQKLVEKIMDQ-------YRVLEPVPLPRTKKGSWLA 1317
             D   H +Q +E +++ NA  ++ ++ +E+  ++        R L+      T+    L+
Sbjct: 1859 EDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLS 1918

Query: 1318 DKVKRLMRPRREGGP 1332
             +V  L    R GGP
Sbjct: 1919 REVSTLKNRLRRGGP 1933



 Score =  114 bits (286), Expect = 5e-25
 Identities = 239/1069 (22%), Positives = 430/1069 (40%), Gaps = 191/1069 (17%)

Query: 213  LSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQ 272
            L+K+  ++++    L E L + E      E   R   +G +  L  Q+A  +AQ+  L+ 
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK-LDGETTDLQDQIAELQAQIDELKL 1083

Query: 273  ELEEKAELLLDSQAE--------------VQGLEAEIRRLRQEAQALSGQAKRAELYREE 318
            +L +K E L  + A               V+ L+A+I  L+++ ++      +AE  +  
Sbjct: 1084 QLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQK-- 1141

Query: 319  AEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAAR 378
                R+ +  L  L+ EL    +   A +  +++ E+E     V E  KAL EE      
Sbjct: 1142 ----RDLSEELEALKTELEDTLDTTAAQQELRTKREQE-----VAELKKALEEE------ 1186

Query: 379  ERCARLHETQRENLLLRTRLGEAHA-ELDSLRHQVDQLAEENVELELELQRSLEPPPGSP 437
                + HE Q +++  R      HA  L+ L  Q++Q       LE   Q  LE      
Sbjct: 1187 ---TKNHEAQIQDMRQR------HATALEELSEQLEQAKRFKANLEKNKQ-GLE-----T 1231

Query: 438  GEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPV 497
                LA     LQ    E+E  R + L+ + +EL    +V +G             +   
Sbjct: 1232 DNKELACEVKVLQQVKAESEHKR-KKLDAQVQELHA--KVSEG-------------DRLR 1275

Query: 498  LPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQE 557
            + + E+A +     D+    L +  + G   A D A  +L+S L+ + E  Q      +E
Sbjct: 1276 VELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAA--SLESQLQDTQELLQ------EE 1327

Query: 558  AESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAP 617
                L  ++   Q      +E  S  E QE  E+A  R +L+        Q   TK +  
Sbjct: 1328 TRQKLNLSSRIRQLE----EEKNSLQEQQEEEEEA--RKNLEKQVLALQSQLADTKKKVD 1381

Query: 618  QLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLE-EQEGPNQGLDLATGQ 676
              L G  E  E  + +L+ +A  L Q   E      +    +   +QE  +  +DL    
Sbjct: 1382 DDL-GTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDL---- 1436

Query: 677  AEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQ 736
                +H +++   +     +K Q+K +  L                  AE++++    A+
Sbjct: 1437 ----DHQRQVASNL-----EKKQKKFDQLL------------------AEEKSISARYAE 1469

Query: 737  LRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREA 796
             R       D  EA+AR+ E   T+A  L++ L +A  A+ E  R+ +    +   L  +
Sbjct: 1470 ER-------DRAEAEAREKE---TKALSLARALEEALEAKEEFERQNKQLRADMEDLMSS 1519

Query: 797  VEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEA---AEERMQVLESEG 853
             +  G+ +    + + AL + +      R Q E     L+A  +A    E  MQ ++++ 
Sbjct: 1520 KDDVGKNVHELEKSKRALEQQVE---EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQF 1576

Query: 854  RQHLEEAERERREKE--------ALQAELEK-------AVVRGKELGARLEHLQRELEQA 898
             + L+  + +  EK+         L+AELE        AV   K++   L+ L+ ++E A
Sbjct: 1577 ERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAA 1636

Query: 899  ALERQEFLREKESQHQRYQGLEQRLEA------ELQAAATSKEEALMELKTRALQLEEEL 952
               R E +++      + +  ++ LE       E+ A +   E+ L  L+   LQL+EEL
Sbjct: 1637 NKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEEL 1696

Query: 953  FQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQ 1012
                +       ++ AE +  E  +  +       + L+ EK  L+ ++  LE +L   Q
Sbjct: 1697 ASSERA------RRHAEQERDELAD-EITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749

Query: 1013 G---------RAQELLLQSQRAQEHSSRLQAEKS-----VLEIQGQELHRKLEVLEEEVR 1058
                      R   L + +  A+  + R  A+KS      LE Q +EL  KL+ LE  V+
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVK 1809

Query: 1059 A----------ARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRA 1108
            +          A+  Q E + +Q+A  ++  A  +L RR E +L+ + ++  D + +   
Sbjct: 1810 SKFKATISALEAKIGQLEEQLEQEA--KERAAANKLVRRTEKKLKEIFMQVEDERRHADQ 1867

Query: 1109 LELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQD----GHRQRGLEEELRRLQSE 1164
             +    +   R +QL+ Q    E +     A R +L ++         GL  E+  L++ 
Sbjct: 1868 YKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNR 1927

Query: 1165 HDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRES 1213
              R   +    SR        R +L    A LEL     E ++  + E+
Sbjct: 1928 LRRGGPISFSSSR------SGRRQLHLEGASLELSDDDTESKTSDVNET 1970



 Score = 92.0 bits (227), Expect = 4e-18
 Identities = 113/488 (23%), Positives = 201/488 (41%), Gaps = 39/488 (7%)

Query: 815  VEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAEL 874
            V+ L    R+  + + +   L    E   +    LE   R+H +  E +    E LQAE 
Sbjct: 841  VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET 900

Query: 875  EKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSK 934
            E      +E+ ARL   ++ELE+   + +  + E+E ++Q  Q  +++++A +Q      
Sbjct: 901  E-LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQ------ 953

Query: 935  EEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEK 994
                         LEE+L +       L  +K      ++     ++ +E  N+  + EK
Sbjct: 954  ------------DLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEK 1001

Query: 995  AALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLE 1054
              ++ ++     QL   + +A+ L     + +   S L+      E   QEL +    L+
Sbjct: 1002 KLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLD 1061

Query: 1055 EEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRD--LKAN-----MR 1107
             E    +    E + Q   L        QL +++E EL+G L R  D  L  N     +R
Sbjct: 1062 GETTDLQDQIAELQAQIDEL------KLQLAKKEE-ELQGALARGDDETLHKNNALKVVR 1114

Query: 1108 ALELAHRELQGRHEQLQAQRASVEAQEVALLAERERL---MQDGHRQRGLEEELR--RLQ 1162
             L+    ELQ   E  +A R   E Q+  L  E E L   ++D       ++ELR  R Q
Sbjct: 1115 ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQ 1174

Query: 1163 SEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSAC 1222
               +  + L  E      ++Q  R      L  L  +  Q +     L ++ Q L+    
Sbjct: 1175 EVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNK 1234

Query: 1223 RLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLN 1282
             L  + ++L Q+++  E + ++L A+VQ L  +  E     +E  +   + Q E LD ++
Sbjct: 1235 ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNE-LDNVS 1293

Query: 1283 ALRREKQK 1290
             L  E +K
Sbjct: 1294 TLLEEAEK 1301



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 68/290 (23%), Positives = 120/290 (41%), Gaps = 47/290 (16%)

Query: 196  ELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLC---LRPEAPSRAPAEGP 252
            E A   LE+  +++     +  + RD   +    LL+++       L  E   RA A   
Sbjct: 1559 EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVAS 1618

Query: 253  SHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRA 312
               + + L + +AQ+    +  +E  + L   QA+++  + E+   R     +  Q+K +
Sbjct: 1619 KKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKES 1678

Query: 313  ELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEE 372
            E      + L+     + +LQEEL       + AE  + +L +E  ++       ALL+E
Sbjct: 1679 E------KKLKSLEAEILQLQEELASSERARRHAEQERDELADE--ITNSASGKSALLDE 1730

Query: 373  --QLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSL 430
              +LEA   R A+L E   E         +++ EL + R +   L  + +  EL  +RS 
Sbjct: 1731 KRRLEA---RIAQLEEELEEE--------QSNMELLNDRFRKTTLQVDTLNAELAAERS- 1778

Query: 431  EPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQG 480
                           A    D  R+        LER+N+EL+  LQ L+G
Sbjct: 1779 ---------------AAQKSDNARQ-------QLERQNKELKAKLQELEG 1806



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 60/289 (20%), Positives = 129/289 (44%), Gaps = 34/289 (11%)

Query: 1036 KSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGL 1095
            K +L++  QE   +L+  +EE+   ++ Q +  G+ + + R H+ L + +     +L+  
Sbjct: 842  KPLLQVTRQE--EELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ-- 897

Query: 1096 LVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERE-RLMQDGHRQRGL 1154
                            A  EL    E+++A+ A+ + +   +L + E R+ ++  R + L
Sbjct: 898  ----------------AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQIL 941

Query: 1155 EEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRESN 1214
            + E +++Q+     +  L E    R +LQ E+     ++ ++E E   LE Q+ +  +  
Sbjct: 942  QNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEK 1001

Query: 1215 QQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQ 1274
            + ++      ++Q         A+EEE  + LA++    R  +E++   LE R     + 
Sbjct: 1002 KLMEDRIAECSSQL--------AEEEEKAKNLAKI----RNKQEVMISDLEERLKKEEKT 1049

Query: 1275 REYLDQL-NALRREKQKLVEKIMDQYRVLEPVPLPRTKKGSWLADKVKR 1322
            R+ L++    L  E   L ++I +    ++ + L   KK   L   + R
Sbjct: 1050 RQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALAR 1098


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  128 bits (322), Expect = 4e-29
 Identities = 236/1165 (20%), Positives = 473/1165 (40%), Gaps = 190/1165 (16%)

Query: 255  HLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAEL 314
            +L   ++  + +L+ +R++LEEK        A  +  +A ++++ Q  Q  + Q    + 
Sbjct: 1061 YLKQTISEKEVELQHIRKDLEEKL-------AAEEQFQALVKQMNQTLQDKTNQIDLLQA 1113

Query: 315  YREEAEALRER----------AGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLE 364
               E +A+ ++             +  ++E +        ++E +K +LEE+ +    LE
Sbjct: 1114 EISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKIL---ALE 1170

Query: 365  ASKALLEEQL-EAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELE 423
              K  L+++L EA   R A L + Q +   LR  L +   + + L+ Q D+ ++EN  + 
Sbjct: 1171 KEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIG 1230

Query: 424  LELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPG 483
             +L++                    LQ +VRE+  G+L + +++        +     PG
Sbjct: 1231 DQLRQ--------------------LQIQVRESIDGKLPSTDQQ--------ESCSSTPG 1262

Query: 484  GQHPLLEAPREDPVLPVLEE--APQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVL 541
             + PL +A  +    PVLE    P  P    HS       A  GG            SV 
Sbjct: 1263 LEEPLFKATEQHHTQPVLESNLCPDWP---SHSEDA---SALQGGT-----------SVA 1305

Query: 542  EASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRR-SSLQS 600
            +  A   Q  + + ++ E  L+ ++   + +    ++S    + QE   K G    SL++
Sbjct: 1306 QIKA---QLKEIEAEKVELELKVSSTTSELT----KKSEEVFQLQEQINKQGLEIESLKT 1358

Query: 601  PASVAPPQGPGT--KIQAPQL-LGGETEGREA-PQGELVPEAWGLRQEGPEHKPGPSEPS 656
             +  A         K+++ QL + G    RE  P+ + + +    ++E   +  G     
Sbjct: 1359 VSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEK 1418

Query: 657  SVQLE-------EQEGPNQGLDLATGQAEAREHDQRLEGTVRD--PAWQKPQQKSEGALE 707
               L        EQE   + L     + +A+EHD+R++    +     QKP++  E +  
Sbjct: 1419 EAALTKIQTEIIEQEDLIKALHTQL-EMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477

Query: 708  VQVWEGPIPGESLA--SGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARL 765
             Q  +  +    ++    + E ++L+EE++  R   E L   L     ++ AQN E   +
Sbjct: 1478 KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV 1537

Query: 766  SKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGR-- 823
               LA  +    +   E +    E   L  + E+    LE  ++++E LV+ + +     
Sbjct: 1538 LGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK 1597

Query: 824  --ERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRG 881
              E  +W+ +   L+ + E   +  + + +E  +     E  R+EK+ L  +L       
Sbjct: 1598 IAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1657

Query: 882  KELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMEL 941
            KE   +L+  ++E+E+   + ++F + K+ +    +    RL AE+  A  + +E +  L
Sbjct: 1658 KETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETL 1717

Query: 942  KTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQL 1001
             +    ++EEL +++     L  K ++     ++ +  + +++      V+++A L+   
Sbjct: 1718 LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATE 1777

Query: 1002 QH------LEGQLGSLQGRAQE-------------------------------------- 1017
            +H       E    S+ G  +E                                      
Sbjct: 1778 KHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINN 1837

Query: 1018 LLLQSQRAQEHSSRLQAEKSVLEIQGQELHR--------------KLEVLEEEVRAA--- 1060
             L Q  + +E  + L+ EK   +   Q L                +L++L+EEV      
Sbjct: 1838 YLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLL 1897

Query: 1061 -RQSQEE---TRGQQQALLRDHKALAQLQRRQEAELEGLL-----------VRHRDLKAN 1105
             +Q QEE       ++    +   L +    Q AEL G +           +++  L++ 
Sbjct: 1898 NQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESE 1957

Query: 1106 MRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEH 1165
            M+ L+    EL+   +QL  ++  VE++   +  E    +Q   ++ G +   + LQ   
Sbjct: 1958 MKNLKKCVSELEEEKQQLVKEKTKVESE---IRKEYLEKIQGAQKEPGNKSHAKELQELL 2014

Query: 1166 DRAQMLLAELSRERGELQGERGELRGRLARLELERAQ----LEMQSQQLRESNQQLDLSA 1221
               Q  + +L ++    Q +   L   +  LE  + +    LE+  + L ++ +    + 
Sbjct: 2015 KEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQ 2074

Query: 1222 CRLTTQCELL--TQLRSAQE-EENRQLLAEVQ-------ALSRENRELLERSLESRDHLH 1271
              L +   LL  TQ  +A+   +N +L  E+Q       +  ++  E LER LE  +  H
Sbjct: 2075 AELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKH 2134

Query: 1272 -REQREYLDQLNALRREKQKLVEKI 1295
             +E++   ++L+ALRREK  L E I
Sbjct: 2135 LKEKKNMQEKLDALRREKVHLEETI 2159



 Score =  112 bits (281), Expect = 2e-24
 Identities = 249/1210 (20%), Positives = 466/1210 (38%), Gaps = 168/1210 (13%)

Query: 149  QCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRS 208
            Q  H  L    I  LS+E +S+      EV Q         +  D  +L  +E   L RS
Sbjct: 787  QTAHDNLLTEQIHSLSIEAKSKDVKI--EVLQ---------NELDDVQLQFSEQSTLIRS 835

Query: 209  LMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLR 268
            L   L     E   GA+R+  +  + E L    +A S+   E     +   L   K  + 
Sbjct: 836  LQSQLQNKESEVLEGAERVRHISSKVEELS---QALSQKELEITK--MDQLLLEKKRDVE 890

Query: 269  RLRQELEEK-----------AELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYRE 317
             L+Q +EEK            E ++    E   L  EI+ L+++   LS   +  E  +E
Sbjct: 891  TLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLS---RAEEAKKE 947

Query: 318  EAEALRERAGRLPRLQEELRRC----RERLQAA-EAYKSQLEE-ERVLSGVLEASKALLE 371
            + E   E +  L +  +E+       +E LQ   +  K + E+ +R L   L   K LL+
Sbjct: 948  QVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQ 1007

Query: 372  EQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLE 431
                   E      E+++E  L  T  GE   + ++  +    +  +  E+E+ L++++ 
Sbjct: 1008 RVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTI- 1066

Query: 432  PPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEA 491
                S  E  L      L++        +L   E+    ++ + Q LQ +   Q  LL+A
Sbjct: 1067 ----SEKEVELQHIRKDLEE--------KLAAEEQFQALVKQMNQTLQDKT-NQIDLLQA 1113

Query: 492  PREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQ-- 549
               +    + +       A D     LV+       + + ++PP   S      E  +  
Sbjct: 1114 EISENQAIIQKLITSNTDASDGDSVALVK-------ETVVISPPCTGSSEHWKPELEEKI 1166

Query: 550  -APDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQ 608
             A + + ++ +  LQ A    +A     QE    +  +E  ++    + LQ        +
Sbjct: 1167 LALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLR-EELKQQKDDYNRLQEQFDEQSKE 1225

Query: 609  GPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQ 668
                  Q  QL   + + RE+  G+L                    PS+ Q +E      
Sbjct: 1226 NENIGDQLRQL---QIQVRESIDGKL--------------------PSTDQ-QESCSSTP 1261

Query: 669  GLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQE 728
            GL+    +A  + H Q +  +   P W      SE A  +Q       G S+A   A+ +
Sbjct: 1262 GLEEPLFKATEQHHTQPVLESNLCPDW---PSHSEDASALQ------GGTSVAQIKAQLK 1312

Query: 729  ALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRA--EAEAHREAEAQ 786
             +  E  +L  K  +   EL  ++ ++     +  +   E+   +    EAE H E+  Q
Sbjct: 1313 EIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQ 1372

Query: 787  AWEQARLREAVEAAGQELESASQEREALVEALA--AAGRERRQWEREGSRLRAQSEAAEE 844
              E ++L+ A     +EL+    E + L+       +    +  E+E +  + Q+E  E+
Sbjct: 1373 KLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQ 1432

Query: 845  RMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGAR---LEHLQRELEQAALE 901
               +     +  ++  E + R K+ LQ EL +   + +E+G      + +QR+L+ A + 
Sbjct: 1433 EDLIKALHTQLEMQAKEHDERIKQ-LQVELCEMKQKPEEIGEESRAKQQIQRKLQAALIS 1491

Query: 902  RQEFLREKESQHQRY---QGLEQRL-----EAELQAAATSKEEALMELKTRALQLEEELF 953
            R+E L+E +S  +     +G  +RL     + E Q +A +KE+  +  +   LQ E +  
Sbjct: 1492 RKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERD-- 1549

Query: 954  QLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQG 1013
                             +L+   +  L+E +  ++   + K AL+G  +  E  +  ++ 
Sbjct: 1550 -----------------KLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIES 1592

Query: 1014 RAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQA 1073
                 + +S   QE    LQ E  +L    + +  + E ++  V A RQ ++E  G+ ++
Sbjct: 1593 LKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRS 1652

Query: 1074 LLRDHKALAQLQRRQEAELEGLLVRHRDL--KANMRALELAHRELQGRHEQLQAQRASVE 1131
               + K   +  +  E E+E +  + R        + LEL     + R E   A   + E
Sbjct: 1653 TEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE 1712

Query: 1132 AQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRG 1191
              E  L +              ++EEL R++ E++        L  E+  L  E  +L+ 
Sbjct: 1713 CMETLLSS-----------NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKH 1761

Query: 1192 RLARLELERAQLEMQSQQLRESN--------------QQLDLSACRLTTQCELLTQLRSA 1237
            ++     ++A LE   +   ++N              +Q  LS     T  E +   +SA
Sbjct: 1762 QIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSA 1821

Query: 1238 ---------QEEENRQLLAEVQALSRENRELLERSLESRDH---LHREQREYLDQLNALR 1285
                       +E    L ++  L      L E   ++++    L  E+   L Q++   
Sbjct: 1822 NPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKD 1881

Query: 1286 REKQKLVEKI 1295
             E + L E++
Sbjct: 1882 GELKMLQEEV 1891



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 237/1158 (20%), Positives = 446/1158 (38%), Gaps = 138/1158 (11%)

Query: 196  ELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHH 255
            EL  AE ++   +L   +  L  + +   Q  AEL      L  + +A      E  SH 
Sbjct: 325  ELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEME---EKTSHI 381

Query: 256  LALQLANAKAQLR--RLRQE----LEEKAELLLDSQAEVQGLEAEIR-----------RL 298
            L+LQ    + Q     L+ +    L++K E  + S   +Q LE +++           RL
Sbjct: 382  LSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRL 441

Query: 299  RQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERV 358
              +    + Q    ++Y E  +A+ E    +  LQ+ +        A      +LEE + 
Sbjct: 442  PLQQHETASQTSFPDVYNEGTQAVTEE--NIASLQKRVVELENEKGALLLSSIELEELKA 499

Query: 359  LSGVLEASKALLEEQ---------------LEAARERCARLHETQRENLLLRTRLGEAHA 403
             +  L +   LLE Q               ++ A +R +   E+ ++  +L     + H 
Sbjct: 500  ENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQD--VLENTFSQKHK 557

Query: 404  ELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRT 463
            EL  L  ++ +  EE   L+L+LQ            A  A      Q E+++ E   +  
Sbjct: 558  ELSVLLLEMKEAQEEIAFLKLQLQGK---------RAEEADHEVLDQKEMKQMEGEGIAP 608

Query: 464  LERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKAR 523
            ++         ++V     G   PL+  P E+  LP +E   +   + +H  +   + + 
Sbjct: 609  IK---------MKVFLEDTGQDFPLM--PNEESSLPAVE---KEQASTEHQSRTSEEISL 654

Query: 524  DGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPV 583
            +     L       D  L A  +  Q    + +  +S +    ++ + +    QE    +
Sbjct: 655  NDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQI----LELELNFHKAQE----I 706

Query: 584  ETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQ 643
              +   EKA   S+L                    L   E   +   Q + +     LR 
Sbjct: 707  YEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTAL--SEERDQLLSQVKELSMVTELRA 764

Query: 644  EGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE 703
            +  + +   +E    +  + E      +L T Q     H   +E   +D   +  Q + +
Sbjct: 765  QVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQI----HSLSIEAKSKDVKIEVLQNELD 820

Query: 704  GALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAA 763
              +++Q  E      SL S +  +E+   E A+  R   +  +EL     + E + T+  
Sbjct: 821  D-VQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMD 879

Query: 764  RLSKELAQARRAEAEAHREAEAQAWE-QARLREAVEAAGQELESASQEREALVEALAAAG 822
            +L  E  +      +   E + Q  E    + E +    +E  S   E + L E L    
Sbjct: 880  QLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLS 939

Query: 823  RERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERE----RREKEALQAELEKAV 878
            R     + +       S   ++    +   G+   EE + E    ++E E  + +L+ A+
Sbjct: 940  RAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAAL 999

Query: 879  VRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEAL 938
            +  KEL  R+  L+ EL     E ++ +   E++    +  ++  E   +   +  +E  
Sbjct: 1000 INRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIE 1059

Query: 939  MELKTRALQLEEELFQLRQGPAGLGPKKRAEPQ---LVETQNVRLIEVERSNAMLVAEKA 995
            + LK    + E EL  +R+    L  K  AE Q   LV+  N  L   +++N        
Sbjct: 1060 IYLKQTISEKEVELQHIRK---DLEEKLAAEEQFQALVKQMNQTL--QDKTN-------- 1106

Query: 996  ALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVL---EIQGQELHRKLEV 1052
                Q+  L+ ++   Q   Q+L+  +  A +  S    +++V+      G   H K E 
Sbjct: 1107 ----QIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPE- 1161

Query: 1053 LEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAEL-EGLLVRHRDLKANMRALEL 1111
            LEE++ A  + +E+ + + Q  L   KA+ +  + +E  L E L  +  D        + 
Sbjct: 1162 LEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDE 1221

Query: 1112 AHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQML 1171
              +E +   +QL+  +  V       L   ++  +      GLEE L +   +H    +L
Sbjct: 1222 QSKENENIGDQLRQLQIQVRESIDGKLPSTDQ-QESCSSTPGLEEPLFKATEQHHTQPVL 1280

Query: 1172 LAEL-------SRERGELQG--ERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSAC 1222
             + L       S +   LQG     +++ +L  +E E+ +LE+          ++  +  
Sbjct: 1281 ESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELEL----------KVSSTTS 1330

Query: 1223 RLTTQCELLTQLRSAQEEENRQLLAEVQAL------SRENRELLERSLESRDHLHREQRE 1276
             LT + E + QL   QE+ N+Q L E+++L      +  + E L++ LES   L     E
Sbjct: 1331 ELTKKSEEVFQL---QEQINKQGL-EIESLKTVSHEAEVHAESLQQKLES-SQLQIAGLE 1385

Query: 1277 YLDQLNALRREKQKLVEK 1294
            +L +L     E QKL+ K
Sbjct: 1386 HLRELQPKLDELQKLISK 1403



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 235/1155 (20%), Positives = 459/1155 (39%), Gaps = 179/1155 (15%)

Query: 266  QLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRER 325
            ++ +++ +L+EK EL+   QA++   +AE     Q AQ+ +                   
Sbjct: 145  EIEKIKHKLQEKEELISTLQAQLTQAQAE-----QPAQSSTE------------------ 181

Query: 326  AGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLH 385
                    EE    +++LQ  E + S L+ +   +   +A++ ++ E+ +A  E   RLH
Sbjct: 182  -------MEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREK-DARFETQVRLH 233

Query: 386  ETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGA 445
            E   + LL      +   E+      + +  EE+ E  +   + ++        A     
Sbjct: 234  E---DELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQ 290

Query: 446  APSLQDEVREAEAGRLR-TLERENRELRGLLQVLQGQPGGQHPLLEAPRED--PVLPVLE 502
              S Q +  EAE   LR T+E E  E + LL+ ++ +   +       +E+   +L   E
Sbjct: 291  ILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFE 350

Query: 503  EAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQ----EA 558
            +A Q     +     L QK +    +          +  E  + C    D + +    + 
Sbjct: 351  QAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKN 410

Query: 559  ESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQ 618
            E  +Q+A    Q  D   Q+S       +   +   R  LQ   + +    P    +  Q
Sbjct: 411  EQAVQSAQTIQQLEDQLQQKS-------KEISQFLNRLPLQQHETASQTSFPDVYNEGTQ 463

Query: 619  LLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLD----LAT 674
             +   TE   A   + V E         E++ G    SS++LEE +  N+ L     L  
Sbjct: 464  AV---TEENIASLQKRVVEL--------ENEKGALLLSSIELEELKAENEKLSSQITLLE 512

Query: 675  GQAEAREHDQRL-EGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREE 733
             Q    E D+ + E ++ D A ++     E   +V         + L+  + E +  +EE
Sbjct: 513  AQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEE 572

Query: 734  VAQLR-----RKAEALGDEL--EAQARKLEAQNTEAARLSKELAQA---------RRAEA 777
            +A L+     ++AE    E+  + + +++E +     ++   L              +  
Sbjct: 573  IAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSL 632

Query: 778  EAHREAEAQAWEQARLREAVEA--AGQELESASQEREALVEALAAAGR-ERRQWEREGSR 834
             A  + +A    Q+R  E +    AG EL+S  Q+ +  + A+   G+  + + ER  S+
Sbjct: 633  PAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQ 692

Query: 835  LRAQSEAAEERMQVLE----------SEGRQHLEE----AERERREKEALQAELEKAVVR 880
            +        +  ++ E          S   Q +EE    A+       AL  E ++ + +
Sbjct: 693  ILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQ 752

Query: 881  GKELG----ARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKE- 935
             KEL      R +  Q E+  A  ERQ  L + ESQ      L +++ + L   A SK+ 
Sbjct: 753  VKELSMVTELRAQVKQLEMNLAEAERQRRL-DYESQTAHDNLLTEQIHS-LSIEAKSKDV 810

Query: 936  --EALM-ELKTRALQLEEELFQLRQGPAGLGPKKR-----AE---------PQLVETQNV 978
              E L  EL    LQ  E+   +R   + L  K+      AE          +L +  + 
Sbjct: 811  KIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQ 870

Query: 979  RLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSV 1038
            + +E+ + + +L+ +K  ++   Q       +++ + Q++   S    E   +L  EK  
Sbjct: 871  KELEITKMDQLLLEKKRDVETLQQ-------TIEEKDQQVTEISFSMTEKMVQLNEEKFS 923

Query: 1039 LEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALA---QLQRRQ-EAELEG 1094
            L ++ + L  +L +L     A ++  EE       L +++  ++   Q+ + + + E + 
Sbjct: 924  LGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDL 983

Query: 1095 LLVRHRDLKANMRALELAHRELQGRHEQLQAQRASV--EAQEVALLAERERLMQDGHRQR 1152
            L   +   K  ++A  +  +EL  R  +L+ + A++  E+++   L+E ER   +  ++ 
Sbjct: 984  LKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKE- 1042

Query: 1153 GLEEELRRLQSEHDRAQMLLAE-LSRERGELQGERGELRGRLARLELERAQLEMQSQQLR 1211
              E   + + S+    ++ L + +S +  ELQ  R +L  +LA  E  +A ++  +Q L+
Sbjct: 1043 NKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQ 1102

Query: 1212 ESNQQLDLSACRLTTQCELLTQLRS----------------------------------- 1236
            +   Q+DL    ++    ++ +L +                                   
Sbjct: 1103 DKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPEL 1162

Query: 1237 -----AQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRR---EK 1288
                 A E+E  QL  ++Q      + +L+++ E   HL  E ++  D  N L+    E+
Sbjct: 1163 EEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQ 1222

Query: 1289 QKLVEKIMDQYRVLE 1303
             K  E I DQ R L+
Sbjct: 1223 SKENENIGDQLRQLQ 1237



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 233/1134 (20%), Positives = 453/1134 (39%), Gaps = 154/1134 (13%)

Query: 201  ELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQL 260
            E E L ++L   L   A+E D   +R+ +L +E   LC   + P     E          
Sbjct: 1431 EQEDLIKALHTQLEMQAKEHD---ERIKQLQVE---LCEMKQKPEEIGEE---------- 1474

Query: 261  ANAKAQL-RRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEA 319
            + AK Q+ R+L+  L  + E L ++++  + L      + +  ++L+    +     +E 
Sbjct: 1475 SRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEK 1534

Query: 320  EALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARE 379
            + +    GRL  LQEE    R++L   E  +S LE +  LS   E+ K  LE   E   +
Sbjct: 1535 DTV---LGRLALLQEE----RDKL-ITEMDRSLLENQS-LSSSCESLKLALEGLTEDKEK 1585

Query: 380  RCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELE-LQRSLEPPPGSPG 438
                +   +   +   T   E H EL    +++   + ENV  E E +Q  +E       
Sbjct: 1586 LVKEIESLKSSKIAESTEWQEKHKELQK-EYEILLQSYENVSNEAERIQHVVE------- 1637

Query: 439  EAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVL 498
                     +++ E +E   G+LR+ E   +E    LQ             EA +E    
Sbjct: 1638 ---------AVRQEKQELY-GKLRSTEANKKETEKQLQ-------------EAEQE---- 1670

Query: 499  PVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEA 558
              +EE  +    F  S Q  + +  +   +      PA D+  E       +  S  +E 
Sbjct: 1671 --MEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEEL 1728

Query: 559  ES-PLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKI--Q 615
            E   ++   +  +      ++     E Q+   +     S Q+           T +  +
Sbjct: 1729 ERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEE 1788

Query: 616  APQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQ---EGPNQGLDL 672
              Q + GETE +++      P             P  S+  S   E     +  +Q  + 
Sbjct: 1789 GTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKER 1848

Query: 673  ATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALRE 732
              G  E ++ ++    T+ +       Q S    E+++ +  +   +L +   ++E  R 
Sbjct: 1849 IAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSR- 1907

Query: 733  EVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQAR 792
             V +L+  AE   D+LE      E    + A L+  +    +   +A  + E    E   
Sbjct: 1908 -VTKLKETAEEEKDDLE------ERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKN 1960

Query: 793  LREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVL--- 849
            L++ V     ELE   +E++ LV+                 + + +SE  +E ++ +   
Sbjct: 1961 LKKCVS----ELE---EEKQQLVK----------------EKTKVESEIRKEYLEKIQGA 1997

Query: 850  --ESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLR 907
              E   + H +E +   +EK+    +L+K  +R +E  + LE   + LE    E Q+ L 
Sbjct: 1998 QKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDL- 2056

Query: 908  EKESQHQRYQGLEQRLEAELQAAA------TSKEEALMELKTRALQLEEELFQLRQGPAG 961
             + ++    Q +E R +A+ + A+       ++ EA   L    L+L++EL   ++    
Sbjct: 2057 -EITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADN-LKLKKELQSNKESVKS 2114

Query: 962  LGPKK--RAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELL 1019
               +K    E +L + +   L E +     L     AL+ +  HLE  +G +Q    +  
Sbjct: 2115 QMKQKDEDLERRLEQAEEKHLKEKKNMQEKL----DALRREKVHLEETIGEIQVTLNKKD 2170

Query: 1020 LQSQRAQEHSSRLQAE-----KSVLEIQGQELHRKLEVLEEEVRAARQSQE--ETRGQQQ 1072
             + Q+ QE+      +     KS+  +Q      +  V++E  +  R+  +  +++ ++ 
Sbjct: 2171 KEVQQLQENLDSTVTQLAAFTKSMSSLQDD----RDRVIDEAKKWERKFSDAIQSKEEEI 2226

Query: 1073 ALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHE-QLQAQRA--- 1128
             L  D+ ++ + Q RQ      + +   +LK N+  LE   +  + + + ++Q Q+    
Sbjct: 2227 RLKEDNCSVLKDQLRQ------MSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD 2280

Query: 1129 SVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGE 1188
            +++ +   LL++ E   +  H     + EL +L+SE    +  L +LS    + + ++G 
Sbjct: 2281 TLQGENKELLSQLE---ETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGN 2337

Query: 1189 LRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQ----LRSAQEEENRQ 1244
            L G + + E +    +   +QL    Q       RL  +  +  Q    L S +EE  + 
Sbjct: 2338 LEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQV 2397

Query: 1245 LLAEVQALS----RENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEK 1294
             +AE++       +E   LL +  E    L  E ++ +D+ N L  E  K ++K
Sbjct: 2398 AIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQL-METLKTIKK 2450



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 142/635 (22%), Positives = 263/635 (41%), Gaps = 92/635 (14%)

Query: 724  VAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARR--------A 775
            + E++ L +E A    K   L +E+      ++  N+E A+L  EL Q R          
Sbjct: 2491 ILEKDQLIQEAAAENNK---LKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIK 2547

Query: 776  EAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRL 835
            +++  +  E Q  +   L        ++L+ + +  E L  +  A   E++   +E   L
Sbjct: 2548 DSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESL 2607

Query: 836  RAQSEAAEERMQVLESEGRQHLEEAERERREKEA--LQAELEKAVVRGKELGARLEHLQR 893
            +        ++  L+ EG   L  A+ + +E+E   L A    +  R  EL   L  +Q+
Sbjct: 2608 KVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQK 2667

Query: 894  ELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELF 953
            E  +   E ++ L+ KE +H  +     R E E      + EE + EL    +++E++L 
Sbjct: 2668 EAAKKVGEIEDKLK-KELKHLHHDAGIMRNETE------TAEERVAELARDLVEMEQKLL 2720

Query: 954  QLRQGPAGL-------GPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQ------ 1000
             + +   GL       G    +     +  N  L E++R     + E A L+ Q      
Sbjct: 2721 MVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRE 2780

Query: 1001 -------------------LQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQA-EKSVLE 1040
                               L HLE     L  + ++LL  S + ++  +++Q+  K++  
Sbjct: 2781 RDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMAS 2840

Query: 1041 IQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHR 1100
            +Q +  H     L  E+   R+S+E   G+Q++  +   + A++Q  ++A       R R
Sbjct: 2841 LQNERDH-----LWNELEKFRKSEE---GKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDR 2892

Query: 1101 DLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGL--EEEL 1158
             LK       L  + LQ   E  +      + QE     +  ++MQ+  RQ  L  + EL
Sbjct: 2893 LLK---ELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHEL 2949

Query: 1159 RRLQSE------HDRAQ-----MLLAELSRERGELQGERGELRGRLARLELERAQLEMQS 1207
             +L+ E      H+R       M +++  ++   LQ    ELR   ++ +  + Q + Q+
Sbjct: 2950 HQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQA 3009

Query: 1208 QQLRESNQQLDLSACRLTTQCELL-TQLRSAQEEENRQLLAEVQALSRENRELLERS--- 1263
                E++   D S   L  + ELL TQL  + +E +++ L  +Q L+    +LLE     
Sbjct: 3010 SP--ETSASPDGSQ-NLVYETELLRTQLNDSLKEIHQKEL-RIQQLNSNFSQLLEEKNTL 3065

Query: 1264 ----LESRDHLHREQREYLDQLN---ALRREKQKL 1291
                 ++   L   Q+ Y D LN    L ++ Q+L
Sbjct: 3066 SIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQEL 3100



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 221/1106 (19%), Positives = 427/1106 (38%), Gaps = 158/1106 (14%)

Query: 262  NAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEA-- 319
            + K+Q+++  ++LE + E     QAE + L+ E + ++++  AL    +R +++ EE   
Sbjct: 2111 SVKSQMKQKDEDLERRLE-----QAEEKHLK-EKKNMQEKLDAL----RREKVHLEETIG 2160

Query: 320  ---EALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKAL------- 369
                 L ++   + +LQE L     +L A     S L+++R    V++ +K         
Sbjct: 2161 EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDR--DRVIDEAKKWERKFSDA 2218

Query: 370  ---LEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELEL 426
                EE++    + C+ L +  R+   +   + E    +  L H   Q+ E   + E++L
Sbjct: 2219 IQSKEEEIRLKEDNCSVLKDQLRQ---MSIHMEELKINISRLEHD-KQIWESKAQTEVQL 2274

Query: 427  QRSLEPPPGSPGEAPLAGAAP------SLQDEVREAEAGRLRTLERENRELRGLLQVLQG 480
            Q+ +        +  L+          S Q+E+ + E+  L++L+ +  +L   L+  + 
Sbjct: 2275 QQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLES-ELKSLKDQLTDLSNSLEKCKE 2333

Query: 481  QPGGQHPLLEAPREDPVLPVL--EEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALD 538
            Q G    ++     D        E+      A       L ++      + + L     +
Sbjct: 2334 QKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEE 2393

Query: 539  SVLEASAECPQAPDSD--------PQEAESPLQAAAMDPQASDWSPQ--ESGSPVETQES 588
            ++  A AE  Q  D +         QE E  +     + +A D + Q  E+   ++ +  
Sbjct: 2394 AIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENI 2453

Query: 589  PEKAGRRSSLQSPASVAPPQGP-------------GTKIQAPQLLGGETEGREAPQGELV 635
             +KA   S ++S +S+   +                  ++  QL+    +   A   +L 
Sbjct: 2454 QQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLI----QEAAAENNKLK 2509

Query: 636  PEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAW 695
             E  GLR    +     ++  +  ++ +E  NQ + +   Q +     Q LE  ++    
Sbjct: 2510 EEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQK-----QLLEVQLQQ--- 2561

Query: 696  QKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKL 755
             K  +     LE ++ E     E L        AL+EE   L ++ E+L   +    R++
Sbjct: 2562 NKELENKYAKLEEKLKESEEANEDLRRSF---NALQEEKQDLSKEIESLKVSISQLTRQV 2618

Query: 756  EAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALV 815
             A   E   L    AQ +  E E HR +   +  Q R+ E  E      + A+++   + 
Sbjct: 2619 TALQEEGT-LGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIE 2677

Query: 816  EALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELE 875
            + L    +E +    +   +R ++E AEER+  L  +  +  ++     +E + L A+++
Sbjct: 2678 DKLK---KELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQ 2734

Query: 876  KAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQR----LEAELQAAA 931
                    L    +H   EL++  L+R+     KE    + QGL  R    L +E   + 
Sbjct: 2735 SFGRSMSSLQNSRDHANEELDE--LKRKYDASLKELAQLKEQGLLNRERDALLSETAFSM 2792

Query: 932  TSKEEA----LMELKTRALQLEEELFQLR-QGPAGLGPKKRAEPQLVETQNVR------- 979
             S EE     L +L  + L  +E+L  L  Q        +     +   QN R       
Sbjct: 2793 NSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNEL 2852

Query: 980  --LIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKS 1037
                + E       A+ +    ++Q L+  + SLQ     LL + +  Q+    LQ  + 
Sbjct: 2853 EKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQY--LQINQE 2910

Query: 1038 VLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQAL------LRDHKALAQLQRRQEAE 1091
            + E+    L  +L+  +++ +A +  QEE R +  +       LR  K+  ++  R+  E
Sbjct: 2911 ITELH--PLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKE 2968

Query: 1092 LEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQ-----------------E 1134
               + +  +D +  +  L+   REL+    Q Q  +   + Q                 E
Sbjct: 2969 QYLMAISDKDQQ--LSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYE 3026

Query: 1135 VALLAER-----ERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGEL 1189
              LL  +     + + Q   R + L     +L  E +   + L + S+   E Q   G+L
Sbjct: 3027 TELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDL 3086

Query: 1190 RGRLARLELERAQLEM----------------------QSQQLRESNQQLDLSACRLTTQ 1227
                A LE +  +L+                         ++LRE  Q    +  +L   
Sbjct: 3087 LNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNT 3146

Query: 1228 CELLTQLRSAQEEENRQLLAEVQALS 1253
             + + +LR   EEE  Q +A   ALS
Sbjct: 3147 RQEVNELRKLLEEERDQRVAAENALS 3172



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 115/533 (21%), Positives = 223/533 (41%), Gaps = 56/533 (10%)

Query: 809  QEREALVEALAAAGRE-----RRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERE 863
            QER A  E L    ++       Q +++   L+ + +AA+ +++ L+   +  L    + 
Sbjct: 51   QERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKY 110

Query: 864  RREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRL 923
              E +A    +     + +E  ++ +    E E    + +  L+EKE      Q    + 
Sbjct: 111  IEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQA 170

Query: 924  EAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRL--- 980
            +AE  A ++++ E  + +K + LQ +EE     Q        ++A  Q+V  ++ R    
Sbjct: 171  QAEQPAQSSTEMEEFVMMK-QQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQ 229

Query: 981  IEVERSNAMLVAEKAALQGQLQH--------LEGQLGSLQGRA-------QELLLQSQRA 1025
            + +     + +  +A ++ ++Q         LE    SL GRA       QEL    QR 
Sbjct: 230  VRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRN 289

Query: 1026 QEHSSRLQ---AE----KSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDH 1078
            Q  S +LQ   AE    ++ +E + +E    LE +E EV   + S    + +   LL   
Sbjct: 290  QILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQF 349

Query: 1079 KALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALL 1138
            +   Q Q   E+    L  +H   KA M         LQ   ++LQ+   +++ Q   LL
Sbjct: 350  EQAGQAQAELESRYSALEQKH---KAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLL 406

Query: 1139 AER-ERLMQDGHRQRGLEEELRR-------------LQSEHDRAQMLLAELSRERGELQG 1184
             ++ E+ +Q     + LE++L++             LQ     +Q    ++  E  +   
Sbjct: 407  QDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVT 466

Query: 1185 ER--GELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEEN 1242
            E     L+ R+  LE E+  L + S +L E   + +    +L++Q  LL + ++   E +
Sbjct: 467  EENIASLQKRVVELENEKGALLLSSIELEELKAENE----KLSSQITLL-EAQNRTGEAD 521

Query: 1243 RQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKI 1295
            R+ ++E+  +   N+         +D L     +   +L+ L  E ++  E+I
Sbjct: 522  RE-VSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEI 573



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 152/730 (20%), Positives = 283/730 (38%), Gaps = 132/730 (18%)

Query: 697  KPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLE 756
            K Q+K E    +Q        E  A    E E       QL+ K E +   L+AQ  + +
Sbjct: 152  KLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFIST-LQAQLSQTQ 210

Query: 757  AQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVE 816
            A+   A ++ +E       +   H +   Q   QA +   ++   + L+   +E E   E
Sbjct: 211  AEQA-AQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHE---E 266

Query: 817  ALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEK 876
            +L    +     ++E +    +++   +++Q +E+E        E ER E + L  ++E 
Sbjct: 267  SLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMEL 326

Query: 877  AVVRGK----ELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAAT 932
             V   K     L   + HL  + EQA   + E          RY  LEQ+ +AE++   +
Sbjct: 327  EVAERKLSFHNLQEEMHHLLEQFEQAGQAQAEL-------ESRYSALEQKHKAEMEEKTS 379

Query: 933  -------------SKEEALMELKTRALQLEEELF------------QLRQGPAGLG---- 963
                         S  +AL +  ++ LQ + E              QL+Q    +     
Sbjct: 380  HILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLN 439

Query: 964  --PKKRAEP--------------QLVETQNV-----RLIEVERSNAMLV----------A 992
              P ++ E               Q V  +N+     R++E+E     L+          A
Sbjct: 440  RLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKA 499

Query: 993  EKAALQGQLQHLEGQ--LGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKL 1050
            E   L  Q+  LE Q   G       E+ +     +  SS  ++ + VLE    + H++L
Sbjct: 500  ENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKEL 559

Query: 1051 EVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALE 1110
             VL  E+   +++QEE      A L+      QLQ ++  E +  ++  +++K  M    
Sbjct: 560  SVLLLEM---KEAQEEI-----AFLK-----LQLQGKRAEEADHEVLDQKEMK-QMEGEG 605

Query: 1111 LAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLEE--------ELRRLQ 1162
            +A  +++   E        +  +E +L A  +      H+ R  EE        EL+  +
Sbjct: 606  IAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTK 665

Query: 1163 SEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSAC 1222
             + D++   + ++ +     Q E   L+ ++  LEL       ++Q++ E N  LD  A 
Sbjct: 666  QDGDKSLSAVPDIGQCH---QDELERLKSQILELELN----FHKAQEIYEKN--LDEKAK 716

Query: 1223 RLTTQCELLTQLR----------SAQEEENRQLLAEVQALS-----RENRELLERSLESR 1267
             ++   +L+ + +          +A  EE  QLL++V+ LS     R   + LE +L   
Sbjct: 717  EISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEA 776

Query: 1268 DHLHREQRE--------YLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRTKKGSWLADK 1319
            +   R   E          +Q+++L  E +    KI      L+ V L  +++ + +   
Sbjct: 777  ERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSL 836

Query: 1320 VKRLMRPRRE 1329
              +L     E
Sbjct: 837  QSQLQNKESE 846



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 81/327 (24%), Positives = 144/327 (44%), Gaps = 41/327 (12%)

Query: 161  QGLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTLSKLARER 220
            Q LS E++S L  +I ++T+     V AL       L  A+L++    +     +L+   
Sbjct: 2598 QDLSKEIES-LKVSISQLTRQ----VTALQEEGTLGLYHAQLKVKEEEV----HRLSALF 2648

Query: 221  DLGAQRLAELLLEREPLCLRPEAPSRAPAEGPS--------HHLALQLAN----AKAQLR 268
                +R+AEL  E E +C++ EA  +               HH A  + N    A+ ++ 
Sbjct: 2649 SSSQKRIAEL--EEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVA 2706

Query: 269  RLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRA-----ELYREEAEALR 323
             L ++L E  + LL    E +GL A+I+   +   +L      A     EL R+   +L+
Sbjct: 2707 ELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLK 2766

Query: 324  ERAGRLPRLQEE--LRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERC 381
            E    L +L+E+  L R R+ L +  A+     EE  LS + + ++ LL +  E      
Sbjct: 2767 E----LAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKD-EQLLHLS 2821

Query: 382  ARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEA- 440
            ++L ++  +       +     E D L +++++  +     E   QRS   P  SP E  
Sbjct: 2822 SQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKS----EEGKQRSAAQPSTSPAEVQ 2877

Query: 441  PLAGAAPSLQDEVREAEAGRLRTLERE 467
             L  A  SLQ++ R+     L+ L+++
Sbjct: 2878 SLKKAMSSLQND-RDRLLKELKNLQQQ 2903



 Score = 37.7 bits (86), Expect = 0.083
 Identities = 76/316 (24%), Positives = 131/316 (41%), Gaps = 51/316 (16%)

Query: 208  SLMGTLSKLARERDL---GAQRLAE----LLLEREPLCLRPEAPSRAPAEG----PSHHL 256
            S + ++S L  +RD      Q+L E    ++LE++ L     A +    E      SH  
Sbjct: 2461 SFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMD 2520

Query: 257  ALQLANAK--AQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAEL 314
             L   NAK  A+L + R++L +   +  DSQ + Q LE +   L+Q  +  +  AK  E 
Sbjct: 2521 DLNSENAKLDAELIQYREDLNQVITIK-DSQQK-QLLEVQ---LQQNKELENKYAKLEEK 2575

Query: 315  YREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQL--------------------- 353
             +E  EA  +       LQEE +   + +++ +   SQL                     
Sbjct: 2576 LKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLK 2635

Query: 354  ---EEERVLSGVLEASK---ALLEEQLEAARERCARL-----HETQRENLLLRTRLGEAH 402
               EE   LS +  +S+   A LEE+L   ++  A+       + ++E   L    G   
Sbjct: 2636 VKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMR 2695

Query: 403  AELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLR 462
             E ++   +V +LA + VE+E +L    +   G   +    G + S     R+     L 
Sbjct: 2696 NETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELD 2755

Query: 463  TLERE-NRELRGLLQV 477
             L+R+ +  L+ L Q+
Sbjct: 2756 ELKRKYDASLKELAQL 2771


>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapiens]
          Length = 1478

 Score =  123 bits (308), Expect = 1e-27
 Identities = 224/976 (22%), Positives = 387/976 (39%), Gaps = 166/976 (17%)

Query: 450  QDEVREAEAG-RLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTP 508
            Q EVRE +   R++ L+REN+ELR  +     Q G Q   L+  RE       +    T 
Sbjct: 241  QLEVREKQLRERMQQLDRENQELRAAVS----QQGEQ---LQTERERGRTAAEDNVRLTC 293

Query: 509  VAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMD 568
            +  +   Q  V +A     + L      L+     +AE  +   +  +  ES LQ  A +
Sbjct: 294  LVAELQKQWEVTQATQNTVKELQTCLQGLEL---GAAEKEEDYHTALRRLESMLQPLAQE 350

Query: 569  PQASDWSPQESGSPVET--------QESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLL 620
             +A+  S  +    + +        Q+  + A      Q P        P    Q  Q L
Sbjct: 351  LEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPI-------PSDAAQEMQEL 403

Query: 621  GGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAR 680
            G + +  E  + ++        +E    +    E    +L+ +E     L+    +    
Sbjct: 404  GEKLQALERERTKV--------EEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPL 455

Query: 681  EHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRK 740
            + +   +G   D  W++ Q   E       WE     E LA        LR E  Q + +
Sbjct: 456  QEELSGKGQEADQLWRRLQ---ELLAHTSSWE-----EELAE-------LRREKKQQQEE 500

Query: 741  AEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAA 800
             E L  E+ +  R+L+   T+ A++S+ ++     + +  ++ +  + +   L       
Sbjct: 501  KELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPP 560

Query: 801  GQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEA 860
            G EL  A ++ EALV   ++    +  W +     R   EA  +  +V E    + L +A
Sbjct: 561  GPELPVAGEKNEALVPVNSSL---QEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQA 617

Query: 861  ERERREKEALQAELEKAVVRGKELGARLEHLQRE---LEQAALERQEFLREKESQHQRYQ 917
             RE      L+ EL+  V R + L  +L+ LQ +   L+Q     Q  L   E++    +
Sbjct: 618  NRE------LEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIR 671

Query: 918  GLEQRLEAELQAAATSKE---------EALMELKT-RALQLEEELFQLRQGPAGLGPKKR 967
             L  ++EA L A   +KE         EA+++ K     QL EE+ Q +Q    L   + 
Sbjct: 672  HLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQ----LAEARH 727

Query: 968  AEPQLVETQ---NVRLIEV--------------ERSNAMLVAEKAALQGQLQHLEGQLGS 1010
             E + +E+Q     +LIEV              +     L A+ A  Q QL+  +G++  
Sbjct: 728  RELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQR 787

Query: 1011 LQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQ-------GQELHRKLEVL---------- 1053
            LQ +  +L  + + A +   ++Q++ S+ E          Q+L  + E L          
Sbjct: 788  LQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQ 847

Query: 1054 ---------EEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKA 1104
                     EE    A+Q +EE R  Q+ L +  K  ++  + + AEL+  L R     A
Sbjct: 848  CSEREGALQEERADEAQQREEELRALQEELSQA-KCSSEEAQLEHAELQEQLHRANTDTA 906

Query: 1105 NM---------------RALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGH 1149
             +                AL  A +ELQ   E    +R  +E Q   L  E+E L +   
Sbjct: 907  ELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLK 966

Query: 1150 RQRGLEEELRRLQSE----HDRAQMLL----AELSRERGELQGERGELRGRLARLELE-- 1199
              +     L  LQ++      RAQ L      EL+  + +L  E  + + RL     E  
Sbjct: 967  AAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECK 1026

Query: 1200 --RAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQ-ALSREN 1256
              R QLE Q +QL+ + + ++       TQ ++  +L           LAE Q A+ R++
Sbjct: 1027 SLRGQLEEQGRQLQAAEEAVEKLK---ATQADMGEKLSCTSNH-----LAECQAAMLRKD 1078

Query: 1257 RELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIM-----DQYRVLEPVPLPRTK 1311
            +E        R+ L R Q+E       ++    KL +++      DQ  + +   L RTK
Sbjct: 1079 KE----GAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTK 1134

Query: 1312 KGSWLADKVKRLMRPR 1327
            K  +L +++  L+R +
Sbjct: 1135 K--YLEERLIELLRDK 1148



 Score =  110 bits (276), Expect = 8e-24
 Identities = 218/975 (22%), Positives = 375/975 (38%), Gaps = 149/975 (15%)

Query: 372  EQLEAARERCA-RLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELE---LELQ 427
            +QLE   ++   R+ +  REN  LR  + +   +L + R +    AE+NV L     ELQ
Sbjct: 240  DQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQ 299

Query: 428  RSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHP 487
            +  E    +            LQ  ++  E G     E  +  LR L  +LQ        
Sbjct: 300  KQWEVTQAT------QNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQ-------- 345

Query: 488  LLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAEC 547
                       P+ +E   T  + D   Q L        P  L +A    D+  +     
Sbjct: 346  -----------PLAQELEATRDSLDKKNQHLA-----SFPGWLAMAQQKADTASDTKGRQ 389

Query: 548  PQAPDSDPQEAE---SPLQAAAMDPQASDWSPQESGSPVE--TQESPEKAGRRSSLQSPA 602
               P    QE +     LQA   +    +   ++  + +E   +E   K   R+SL+   
Sbjct: 390  EPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLV 449

Query: 603  SVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEE 662
                P            L  E  G+    G+   + W   QE   H     E  +    E
Sbjct: 450  KEMAP------------LQEELSGK----GQEADQLWRRLQELLAHTSSWEEELAELRRE 493

Query: 663  QEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLAS 722
            ++   +  +L   + E R   ++L+      A     Q S+   +++        E    
Sbjct: 494  KKQQQEEKELL--EQEVRSLTRQLQFLETQLA-----QVSQHVSDLE--------EQKKQ 538

Query: 723  GVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHRE 782
             + +++ L ++V  L R A   G EL     K EA     + L          EA    E
Sbjct: 539  LIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQ---------EAWGKPE 589

Query: 783  AEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAA 842
             E +  ++A+L +       +++  SQE E     L  A RE    E+E   +  +++  
Sbjct: 590  EEQRGLQEAQLDDT------KVQEGSQEEE-----LRQANRE---LEKELQNVVGRNQLL 635

Query: 843  EERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALER 902
            E ++Q L+++  Q L++ E   +   A   E E+A +R   LG ++E     + +A    
Sbjct: 636  EGKLQALQAD-YQALQQRESAIQGSLA-SLEAEQASIR--HLGDQMEASLLAVRKAKEAM 691

Query: 903  QEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEE-----ELFQLRQ 957
            +  + EKE+  Q  +G  Q+L  E++      E    EL+    Q ++     E+    +
Sbjct: 692  KAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEK 751

Query: 958  GPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQE 1017
            G  G+GP    E +          E+    A+  A+    QG++Q L+ Q+  LQ + + 
Sbjct: 752  GQQGVGPPTDNEAR----------ELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRA 801

Query: 1018 LLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRD 1077
             L    + Q   S+L   ++VL  + + L ++L+   E +  A   +     +++  L++
Sbjct: 802  ALDDQDKVQ---SQLSMAEAVLR-EHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQE 857

Query: 1078 HKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVAL 1137
             +A    QR  E EL  L       K +    +L H ELQ +  +     A +  Q  AL
Sbjct: 858  ERADEAQQR--EEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCAL 915

Query: 1138 LAERERL----------MQD-----GHRQRGLEEELRRLQSEHDRAQMLLAELSRERGEL 1182
              E+ER+          +QD        + GLE ++  LQ E +  Q  L       G L
Sbjct: 916  TVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSL 975

Query: 1183 QGERGELRGRLARLE--LERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEE 1240
             G + +L     R +   E A  E+ + + + S + +D  + RL    E    LR   EE
Sbjct: 976  PGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQS-RLKNAGEECKSLRGQLEE 1034

Query: 1241 ENRQLLA---EVQALSRENRELLERSLESRDHLHREQREYL----------DQLNALRRE 1287
            + RQL A    V+ L     ++ E+   + +HL   Q   L          + L   ++E
Sbjct: 1035 QGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKE 1094

Query: 1288 KQKLVEKIMDQYRVL 1302
             +K   KI + Y  L
Sbjct: 1095 LEKATTKIQEYYNKL 1109



 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 194/827 (23%), Positives = 326/827 (39%), Gaps = 102/827 (12%)

Query: 257  ALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYR 316
            A ++     +L+ L +E  +  E+     A+++ L  E+ +L+++A     +A    L +
Sbjct: 397  AQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKEL-QLKEDA-----RASLERLVK 450

Query: 317  EEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEA 376
            E A    E +G+     +  RR +E L    +++ +L E R      +  K LLE+++ +
Sbjct: 451  EMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRS 510

Query: 377  ARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGS 436
                        R+   L T+L +    +  L  Q  QL ++   L  ++   LE   G 
Sbjct: 511  ----------LTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQV-GMLERLAGP 559

Query: 437  PG-EAPLAG--------AAPSLQ------------------DEVREAEAGRLRTLERENR 469
            PG E P+AG           SLQ                  D+ +  E  +   L + NR
Sbjct: 560  PGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANR 619

Query: 470  ELRGLLQVLQGQPGGQHPLLEAPRED-PVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQ 528
            EL   LQ + G+       L+A + D   L   E A Q  +A   + Q  ++   D    
Sbjct: 620  ELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEA 679

Query: 529  ALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQE-SGSPVETQE 587
            +L     A +++    AE      S   E +   +      Q ++   +E      + Q+
Sbjct: 680  SLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQ 739

Query: 588  SPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPE 647
              +     ++ +    V PP     +  A QL   + +  E  QGE+        Q    
Sbjct: 740  QTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQ-LEVHQGEV--------QRLQA 790

Query: 648  HKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALE 707
                        L++Q+     L +A  +A  REH   +         Q+ ++++E    
Sbjct: 791  QVVDLQAKMRAALDDQDKVQSQLSMA--EAVLREHKTLV---------QQLKEQNEALNR 839

Query: 708  VQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSK 767
              V E     E      A QE   +E  Q   +  AL +EL       E    E A L +
Sbjct: 840  AHVQELLQCSEREG---ALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQE 896

Query: 768  ELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQEL----ESASQEREALVEALAAAGR 823
            +L +A    AE   +  A   E+ R+ EA+  A QEL    E+AS+ERE L   +A   +
Sbjct: 897  QLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQ 956

Query: 824  ERRQWERE--------GS--RLRAQSEAAEERMQVLESEGRQHLEEAERE-RREKEALQA 872
            E+   + +        GS   L+AQ   AE+R Q L+    Q L   + +   E    Q+
Sbjct: 957  EKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQS 1016

Query: 873  ELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAAT 932
             L+ A    K L  +LE   R+L QAA E  E L+  ++             AE QAA  
Sbjct: 1017 RLKNAGEECKSLRGQLEEQGRQL-QAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAML 1075

Query: 933  SKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEV---ERSNAM 989
             K++    L+    + ++EL             ++A  ++ E  N    EV   ER++  
Sbjct: 1076 RKDKEGAALREDLERTQKEL-------------EKATTKIQEYYNKLCQEVTNRERNDQK 1122

Query: 990  LVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEK 1036
            ++A+   L    ++LE +L  L  R ++ L Q   A E   +L AE+
Sbjct: 1123 MLADLDDLNRTKKYLEERLIELL-RDKDALWQKSDALEFQQKLSAEE 1168



 Score = 98.2 bits (243), Expect = 5e-20
 Identities = 207/840 (24%), Positives = 348/840 (41%), Gaps = 101/840 (12%)

Query: 272  QELEEKAELLLDSQAEVQGLE----AEIRRLRQEAQALS-GQAKRAELYREEAEALRERA 326
            QEL EK + L   + +V+ +     A++ +L +E Q     +A    L +E A    E +
Sbjct: 401  QELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELS 460

Query: 327  GRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHE 386
            G+     +  RR +E L    +++ +L E R      +  K LLE+++ +          
Sbjct: 461  GKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLT-------- 512

Query: 387  TQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPG-EAPLAGA 445
              R+   L T+L +    +  L  Q  QL ++   L  ++   LE   G PG E P+AG 
Sbjct: 513  --RQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGM-LERLAGPPGPELPVAGE 569

Query: 446  APSLQDEVREAEAGRLRTLERENRELR-GLLQVLQGQPGGQHP-LLEAPREDPVLPVLEE 503
                   V  +        E E R L+   L   + Q G Q   L +A RE      LE+
Sbjct: 570  KNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRE------LEK 623

Query: 504  APQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSD-PQEAESPL 562
              Q  V  +   +G +Q A     QAL     A+   L AS E  QA       + E+ L
Sbjct: 624  ELQNVVGRNQLLEGKLQ-ALQADYQALQQRESAIQGSL-ASLEAEQASIRHLGDQMEASL 681

Query: 563  QAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGG 622
             A     +A      E  + ++++E  E    R  ++    +A       + +  +L   
Sbjct: 682  LAVRKAKEAMKAQMAEKEAILQSKEG-ECQQLREEVEQCQQLA-------EARHRELRAL 733

Query: 623  ETEGREAPQG-ELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEARE 681
            E++ ++  Q  E++    G +  GP     P++  + +L  Q        LA  QA+   
Sbjct: 734  ESQCQQQTQLIEVLTAEKGQQGVGP-----PTDNEARELAAQ--------LALSQAQLEV 780

Query: 682  HD---QRLEGTVRDPAWQKPQQKSEGALEVQ--------VWEGPI-PGESLASGVAEQ-E 728
            H    QRL+  V D      Q K   AL+ Q        + E  +   ++L   + EQ E
Sbjct: 781  HQGEVQRLQAQVVDL-----QAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNE 835

Query: 729  AL-REEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQA 787
            AL R  V +L + +E  G   E +A + + +  E   L +EL+QA+ +  EA  E     
Sbjct: 836  ALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQ 895

Query: 788  WEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQ 847
             +  R        G ++ + + E+E + EALA A +E +  +   SR R   E  E ++ 
Sbjct: 896  EQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASRER---EGLERQVA 952

Query: 848  VLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLR 907
             L+              +EKE+LQ +L+ A    K     L  LQ +L QA    Q    
Sbjct: 953  GLQ--------------QEKESLQEKLKAA----KAAAGSLPGLQAQLAQAEQRAQSL-- 992

Query: 908  EKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKR 967
             +E+ HQ    L+ +L AE+    +  + A  E K+   QLEE+  QL+     +   K 
Sbjct: 993  -QEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKA 1051

Query: 968  AEPQLVE----TQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQ 1023
             +  + E    T N  L E + +      E AAL+  L+  + +L     + QE    ++
Sbjct: 1052 TQADMGEKLSCTSN-HLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQE--YYNK 1108

Query: 1024 RAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQ 1083
              QE ++R + ++ +L     +L+R  + LEE +    + ++    +  AL    K  A+
Sbjct: 1109 LCQEVTNRERNDQKML-ADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAE 1167



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 100/438 (22%), Positives = 166/438 (37%), Gaps = 36/438 (8%)

Query: 868  EALQAELEKAVVRGKELGARLEHLQRELEQ--AALERQEFLREKESQHQRYQGLEQRLEA 925
            + ++ EL++  VR K+L  R++ L RE ++  AA+ +Q    + E +  R    +     
Sbjct: 233  DEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLT 292

Query: 926  ELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVER 985
             L A    + E     +    +L+  L  L  G A          +  E  +  L  +E 
Sbjct: 293  CLVAELQKQWEVTQATQNTVKELQTCLQGLELGAA----------EKEEDYHTALRRLES 342

Query: 986  SNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQE 1045
                L  E  A +  L      L S  G       ++  A +   R +   S    + QE
Sbjct: 343  MLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQE 402

Query: 1046 LHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKAN 1105
            L  KL+ LE E    R   EE   QQ A L       QL+    A LE L+     L+  
Sbjct: 403  LGEKLQALERE----RTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEE 458

Query: 1106 MRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEH 1165
            +        +L  R ++L A  +S E +   L  E++   Q    +  LE+E+R L  + 
Sbjct: 459  LSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKK---QQQEEKELLEQEVRSLTRQL 515

Query: 1166 DRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLT 1225
               +  LA++S+               ++ LE ++ QL      L +    L+  A    
Sbjct: 516  QFLETQLAQVSQ--------------HVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPG 561

Query: 1226 TQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALR 1285
             +  +  +   A    N  L         E R L E  L+        Q E L Q N   
Sbjct: 562  PELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQAN--- 618

Query: 1286 REKQKLVEKIMDQYRVLE 1303
            RE +K ++ ++ + ++LE
Sbjct: 619  RELEKELQNVVGRNQLLE 636



 Score = 54.7 bits (130), Expect = 7e-07
 Identities = 87/375 (23%), Positives = 156/375 (41%), Gaps = 34/375 (9%)

Query: 1022 SQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLE---EEVRAARQSQ------EETRGQQQ 1072
            +  A E    ++ E   LE++ ++L  +++ L+   +E+RAA   Q      E  RG+  
Sbjct: 225  NNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTA 284

Query: 1073 AL--LRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQ-GRHEQLQAQRAS 1129
            A   +R    +A+LQ++ E   +      ++L+  ++ LEL   E +   H  L+   + 
Sbjct: 285  AEDNVRLTCLVAELQKQWEVT-QATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESM 343

Query: 1130 VEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGEL 1189
            ++     L A R+ L +           L   Q + D A            +   E  EL
Sbjct: 344  LQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQEL 403

Query: 1190 RGRLARLELERAQLE----MQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQL 1245
              +L  LE ER ++E     QS QL +  ++L L      +   L+ ++   QEE + + 
Sbjct: 404  GEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKG 463

Query: 1246 LAEVQALSRENRELLERSL---ESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVL 1302
              E   L R  +ELL  +    E    L RE+++  ++   L +E + L      Q + L
Sbjct: 464  -QEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTR----QLQFL 518

Query: 1303 EPVPLPRTKKGSWLADKVKRLMRPRREGGPPGGLRLGADGAGSTESLGGPPETELPEGRE 1362
            E      ++  S L ++ K+L++ +            +   G  E L GPP  ELP   E
Sbjct: 519  ETQLAQVSQHVSDLEEQKKQLIQDKDHL---------SQQVGMLERLAGPPGPELPVAGE 569

Query: 1363 ADGTGSPSPAPMRRA 1377
             +    P  + ++ A
Sbjct: 570  KNEALVPVNSSLQEA 584



 Score = 50.8 bits (120), Expect = 9e-06
 Identities = 76/314 (24%), Positives = 135/314 (42%), Gaps = 44/314 (14%)

Query: 202 LEMLSRSLMGTLSKLARE----RDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLA 257
           L+    ++ G+L+ L  E    R LG Q  A LL  R+      EA     AE  +    
Sbjct: 649 LQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKA----KEAMKAQMAEKEAI--- 701

Query: 258 LQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYRE 317
             L + + + ++LR+E+E+  +L      E++ LE++ ++  Q  + L+ +  +  +   
Sbjct: 702 --LQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPP 759

Query: 318 EAEALRERAGRLPRLQEELRRCRERLQAAEA--------YKSQLEEERVLSGVLEASKAL 369
                RE A +L   Q +L   +  +Q  +A         ++ L+++  +   L  ++A+
Sbjct: 760 TDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAV 819

Query: 370 LEE------QLEAARERCARLHE------TQRENLLLRTRLGEAHAELDSLRHQVDQLAE 417
           L E      QL+   E   R H       ++RE  L   R  EA    + LR   ++L++
Sbjct: 820 LREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQ 879

Query: 418 -----ENVELE-LELQRSLEPPPGSPGEAPLAGAAPSLQDE-VREAEAGRLRTL----ER 466
                E  +LE  ELQ  L        E  +   A +++ E V EA A  ++ L    E 
Sbjct: 880 AKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEA 939

Query: 467 ENRELRGLLQVLQG 480
            +RE  GL + + G
Sbjct: 940 ASREREGLERQVAG 953



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 71/314 (22%), Positives = 124/314 (39%), Gaps = 26/314 (8%)

Query: 128  LSEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGVVL 187
            L ++  EQ E + R  +   +QC  RE  ++  +    + + E   A+QE          
Sbjct: 826  LVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQ------ 879

Query: 188  ALSGPDPGELAPAEL-EMLSRSLMGTLSKLARERDLGAQRLAELLLEREPL--CLRPEAP 244
            A    +  +L  AEL E L R+   T        +LG Q  A L +E+E +   L     
Sbjct: 880  AKCSSEEAQLEHAELQEQLHRANTDTA-------ELGIQVCA-LTVEKERVEEALACAVQ 931

Query: 245  SRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQA 304
                A+  +      L    A L++ ++ L+EK +    +   + GL+A++ +  Q AQ+
Sbjct: 932  ELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQS 991

Query: 305  LSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLE 364
            L  +A   EL   + +   E      RL+     C+      E    QL+        L+
Sbjct: 992  LQ-EAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLK 1050

Query: 365  ASKALLEEQLEAARERCAR----LHETQRENLLLRTRLGEAHAELD----SLRHQVDQLA 416
            A++A + E+L       A     +    +E   LR  L     EL+     ++   ++L 
Sbjct: 1051 ATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLC 1110

Query: 417  EENVELELELQRSL 430
            +E    E   Q+ L
Sbjct: 1111 QEVTNRERNDQKML 1124


>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
          Length = 1460

 Score =  119 bits (297), Expect = 3e-26
 Identities = 223/938 (23%), Positives = 396/938 (42%), Gaps = 166/938 (17%)

Query: 417  EENVELELELQRSLEPPPGSP-GEAPLAGAAPSLQDEVREA--EAGRLRTLERENRELRG 473
            EEN + E ++ R+L  P   P G  P   +     ++  +A  E  R     +E ++   
Sbjct: 314  EENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKAS 373

Query: 474  LLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLA 533
             L+        +  + E  +E  +   +   P++    D   +  + +        LD+ 
Sbjct: 374  ALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISE------HLLDV- 426

Query: 534  PPALDSVLEASAECPQAP-----DSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQES 588
               L  VL  +    Q P       D Q ++  LQ           S Q  G  +E + S
Sbjct: 427  -DVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQ-----------SKQSKG--LEERLS 472

Query: 589  PEKAGRRSSLQSPASVA----PPQGPGTKIQAPQLLGGETEGREAPQ-GELVPEAWGLRQ 643
            P       +   P S+A    PPQGP           G+ E +EA + GE    +  L Q
Sbjct: 473  PPLPHEERAQSPPRSLATEEEPPQGPE----------GQPEWKEAEELGEDSAASLSL-Q 521

Query: 644  EGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE 703
               + +  PS P++ + + +E  +Q  +L  GQ EA + ++++  +   P          
Sbjct: 522  LSLQREQAPSPPAACE-KGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPV--------- 571

Query: 704  GALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAA 763
             + EV+  E   P E L+   A  +A+ E VAQ+           + Q   LE++  +  
Sbjct: 572  -SPEVRSTEPVAPPEQLSE--AALKAMEEAVAQVLE---------QDQRHLLESKQEKMQ 619

Query: 764  RLSKELAQARRAEA-EAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAG 822
            +L ++L Q    E    H++ E      + LRE ++ A +E E+  +E E+         
Sbjct: 620  QLREKLCQEEEEEILRLHQQKEQSL---SSLRERLQKAIEEEEARMREEES--------- 667

Query: 823  RERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGK 882
             +R  W R  +++++ ++A E++++  +    Q L E E E ++K A +A LE+   + +
Sbjct: 668  -QRLSWLR--AQVQSSTQADEDQIRAEQEASLQKLRE-ELESQQK-AERASLEQ---KNR 719

Query: 883  ELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAEL-QAAATSKEEALMEL 941
            ++   LE L+ E+E  A E+ E      ++ +  Q L ++LE E  +A AT ++E   EL
Sbjct: 720  QM---LEQLKEEIE--ASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAEL 774

Query: 942  KTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQ--- 998
            +     LE +                   ++V +   ++ E ++       E+A LQ   
Sbjct: 775  ERLCSSLEAK-----------------HREVVSSLQKKIQEAQQK------EEAQLQKCL 811

Query: 999  GQLQHLEGQLG-SLQGRAQEL--LLQSQRAQ---EHSSRLQAEKSVLEIQGQELHRKLEV 1052
            GQ++H   Q    + G   EL  LL+ +R +   EH  RL   K   E   Q + +  E 
Sbjct: 812  GQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMK---EEHQQVMAKAREQ 868

Query: 1053 LEEEVRAAR-QSQEETRGQQQALLRDH-KALAQLQRRQEAELEGLLVRHRDLKANMRALE 1110
             E E R  R +      G+ + L R H + L  +++ Q   LE L  RHR+ +  ++ LE
Sbjct: 869  YEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLE 928

Query: 1111 LAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLE-EELRRLQSEHDRAQ 1169
            L   +L+ R + ++A+ A +E QE     E+++L+ D  RQ  L+ EE      + + AQ
Sbjct: 929  L---DLETRAKDVKARLALLEVQEETARREKQQLL-DVQRQVALKSEEATATHQQLEEAQ 984

Query: 1170 MLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCE 1229
                 L +   +L+    EL+ R  +LE +   L+ QSQQL++    L+  A +   +  
Sbjct: 985  KEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK---KQH 1041

Query: 1230 LLTQLRSAQE------------EENRQLLAEVQ------ALSRENRELLERSLESRDHLH 1271
            LL ++   +             E+ R+ L   Q      +LS+   +L   SL S +  H
Sbjct: 1042 LLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWH 1101

Query: 1272 ---------REQREYLDQLNALRREKQKLVEKIMDQYR 1300
                     R  +E+L Q     R +Q  ++     +R
Sbjct: 1102 LLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWR 1139



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 79/301 (26%), Positives = 135/301 (44%), Gaps = 39/301 (12%)

Query: 146 ASVQCEHRELFIRHIQGLSLEVQSELAA-------AIQEVTQPGAG----VVLALSGPDP 194
           AS++ ++R++  +  + +    +SE AA       A+Q++ +   G     V  L     
Sbjct: 712 ASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHS 771

Query: 195 GELAP--AELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGP 252
            EL    + LE   R ++ +L K  +E    AQ+  E  L++   CL  +   R   +  
Sbjct: 772 AELERLCSSLEAKHREVVSSLQKKIQE----AQQKEEAQLQK---CLG-QVEHRVHQK-- 821

Query: 253 SHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEV---------QGLEAEIRRLRQEAQ 303
           S+H+A       + LR  RQE+E + E  LD   E          +  EAE R+ R E  
Sbjct: 822 SYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELL 881

Query: 304 A-LSGQAKRAELYRE-EAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSG 361
             L+G+ +R +   E E E +R+   +  RL++  RR RE+ +  +  +  LE     + 
Sbjct: 882 GHLTGELERLQRAHERELETVRQEQHK--RLEDLRRRHREQERKLQDLELDLETR---AK 936

Query: 362 VLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVE 421
            ++A  ALLE Q E AR    +L + QR+  L        H +L+  + +   L + N +
Sbjct: 937 DVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQ 996

Query: 422 L 422
           L
Sbjct: 997 L 997



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 65/245 (26%), Positives = 104/245 (42%), Gaps = 32/245 (13%)

Query: 261 ANAKAQLRRLRQELE-----EKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELY 315
           A  +A L++LR+ELE     E+A L   ++  ++ L+ EI    +  QA    AK   L 
Sbjct: 690 AEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ 749

Query: 316 REEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLE 375
           +   +   ER   +  L++E     ERL ++   K +     +   + EA     +++ E
Sbjct: 750 QLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEA-----QQKEE 804

Query: 376 AARERCA-----RLH---------ETQRENLLLRTRL---GEAHAELDSLRHQVDQL--- 415
           A  ++C      R+H         E +  +LL   R    GE    LD ++ +  Q+   
Sbjct: 805 AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAK 864

Query: 416 AEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDE-VREAEAGRLRTLERENRELRGL 474
           A E  E E   QR+ E      GE      A   + E VR+ +  RL  L R +RE    
Sbjct: 865 AREQYEAEERKQRA-ELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERK 923

Query: 475 LQVLQ 479
           LQ L+
Sbjct: 924 LQDLE 928



 Score = 39.3 bits (90), Expect = 0.028
 Identities = 76/326 (23%), Positives = 131/326 (40%), Gaps = 48/326 (14%)

Query: 194 PGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPS 253
           P +L+ A L+ +  ++   L +   +R L   +  ++   RE LC   E       +   
Sbjct: 584 PEQLSEAALKAMEEAVAQVLEQ--DQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKE 641

Query: 254 HHLA-----LQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQ 308
             L+     LQ A  + + R   +E +  + L    Q+  Q  E +IR  ++ +     +
Sbjct: 642 QSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLRE 701

Query: 309 AKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAA-----EAYKSQLEEERVLSGVL 363
              ++   E A   ++    L +L+EE+    +  QAA     E    QL E+  L G  
Sbjct: 702 ELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQ--LEGER 759

Query: 364 EASKALLEEQLEAARER-CARLHETQRENL-LLRTRLGEAHAE--------LDSLRHQVD 413
           + + A LE++  A  ER C+ L    RE +  L+ ++ EA  +        L  + H+V 
Sbjct: 760 KEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVH 819

Query: 414 Q---------------LAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEA 458
           Q               L E+  E+E E +R L+       +  +A A    + E R+  A
Sbjct: 820 QKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMK-EEHQQVMAKAREQYEAEERKQRA 878

Query: 459 -------GRLRTLER-ENRELRGLLQ 476
                  G L  L+R   REL  + Q
Sbjct: 879 ELLGHLTGELERLQRAHERELETVRQ 904



 Score = 38.5 bits (88), Expect = 0.048
 Identities = 50/195 (25%), Positives = 79/195 (40%), Gaps = 37/195 (18%)

Query: 233 EREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLE 292
           E E LC   EA  R         +       +AQL++   ++E +          V G E
Sbjct: 773 ELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVH---QKSYHVAGYE 829

Query: 293 AEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQ 352
            E+  L +E              R+E E   ER  RL +++EE ++   +  A E Y+++
Sbjct: 830 HELSSLLREK-------------RQEVEGEHER--RLDKMKEEHQQVMAK--AREQYEAE 872

Query: 353 LEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSL--RH 410
             ++R          A L   L    ER  R HE +     L T   E H  L+ L  RH
Sbjct: 873 ERKQR----------AELLGHLTGELERLQRAHERE-----LETVRQEQHKRLEDLRRRH 917

Query: 411 QVDQLAEENVELELE 425
           +  +   +++EL+LE
Sbjct: 918 REQERKLQDLELDLE 932



 Score = 38.5 bits (88), Expect = 0.048
 Identities = 65/270 (24%), Positives = 106/270 (39%), Gaps = 26/270 (9%)

Query: 130  EEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGVVLAL 189
            +EA ++ E  L+  LG      H++ +  H+ G   E+ S L    QEV           
Sbjct: 797  QEAQQKEEAQLQKCLGQVEHRVHQKSY--HVAGYEHELSSLLREKRQEV----------- 843

Query: 190  SGPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPA 249
             G     L   + E             A ER   A+ L  L  E E L    E       
Sbjct: 844  EGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVR 903

Query: 250  EGPSHHLALQLANAKAQLRRLRQ---ELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALS 306
            +     L       + Q R+L+    +LE +A+   D +A +  LE +    R+E Q L 
Sbjct: 904  QEQHKRLEDLRRRHREQERKLQDLELDLETRAK---DVKARLALLEVQEETARREKQQLL 960

Query: 307  GQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEAS 366
               ++  L  EEA A  +      +L+E  +     LQ+ +  +  L+E +     LE+ 
Sbjct: 961  DVQRQVALKSEEATATHQ------QLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQ 1014

Query: 367  KALLEEQLEAARERCARLH-ETQRENLLLR 395
              LL+ Q +  ++  + L  E Q++  LLR
Sbjct: 1015 VDLLQAQSQQLQKHFSSLEAEAQKKQHLLR 1044


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  116 bits (290), Expect = 2e-25
 Identities = 229/1035 (22%), Positives = 423/1035 (40%), Gaps = 173/1035 (16%)

Query: 256  LALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELY 315
            L  +L+ ++  L R+  EL EK E         Q L+ E+  +  + Q L  + K+ +  
Sbjct: 349  LQSRLSASETSLHRIHVELSEKGEA-------TQKLKEELSEVETKYQHLKAEFKQLQQQ 401

Query: 316  REEAEALRERAGRLPRLQEELRRCRERL-----QAAEAYKSQLEEERVLSGVLEASKALL 370
            REE    +E+ G   +LQ E+ +   +L     Q  EA+  +L+E+R LS      K   
Sbjct: 402  REE----KEQHGL--QLQSEINQLHSKLLETERQLGEAH-GRLKEQRQLSSEKLMDK--- 451

Query: 371  EEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSL 430
            E+Q+   + + +RL E  +E +   T L          +HQ+D+  +++ E +  LQ+S 
Sbjct: 452  EQQVADLQLKLSRLEEQLKEKVTNSTEL----------QHQLDKTKQQHQEQQA-LQQST 500

Query: 431  EPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLE 490
                     A L  A   L+  +R+     +   +++ + L  LLQ  +        LLE
Sbjct: 501  T--------AKLREAQNDLEQVLRQ-----IGDKDQKIQNLEALLQKSKENIS----LLE 543

Query: 491  APREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQA 550
              RED    +     +T V        L +K      Q   L    L +  E+  +  + 
Sbjct: 544  KEREDLYAKIQAGEGETAVL-----NQLQEKNHTLQEQVTQLTEK-LKNQSESHKQAQEN 597

Query: 551  PDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGP 610
                 QE ++ L+AA     + + S  E  S  +  ES EK  +                
Sbjct: 598  LHDQVQEQKAHLRAAQDRVLSLETSVNELNS--QLNESKEKVSQLD-------------- 641

Query: 611  GTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGL 670
              +I+A   L    E  +  Q   +       Q   + K       + QL++     Q  
Sbjct: 642  -IQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQ-- 698

Query: 671  DLATGQAEAREHDQRLEGTVRD--PAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQE 728
                   + +EH  +LE  +++    +   +QK+E  LE Q+       + L +   E +
Sbjct: 699  -------DKQEHCSQLESHLKEYKEKYLSLEQKTE-ELEGQI-------KKLEADSLEVK 743

Query: 729  ALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAW 788
            A +E+  Q  ++   L  +LE +A +L  Q      + KE+  + R + +          
Sbjct: 744  ASKEQALQDLQQQRQLNTDLELRATELSKQ----LEMEKEIVSSTRLDLQ---------- 789

Query: 789  EQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQV 848
               +  EA+E+  Q+L    +E++ L          ++ +E      + Q E    R+Q 
Sbjct: 790  ---KKSEALESIKQKLTKQEEEKQIL----------KQDFETLSQETKIQHEELNNRIQT 836

Query: 849  LESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLRE 908
                    + E ++ + EKEAL  EL     +  ++   L++ + E E+   + +  + +
Sbjct: 837  T-------VTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILD 889

Query: 909  -----KESQHQRYQGLEQRL--EAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAG 961
                 KE +HQ    +E  L  + EL+ +   ++EA  +LK     ++E+L Q +     
Sbjct: 890  LEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQN---T 946

Query: 962  LGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQ 1021
            L   ++ E QL    N    E+++S+     +  ALQG+L+    Q   L+ + Q+ L  
Sbjct: 947  LKQNEKEEQQLQGNIN----ELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL-- 1000

Query: 1022 SQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKAL 1081
            +Q AQE    L AEK  + +      +  E         +Q Q +  G++  LL   + L
Sbjct: 1001 TQAAQE----LAAEKEKISVLQNNYEKSQETF-------KQLQSDFYGRESELLATRQDL 1049

Query: 1082 AQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAER 1141
              ++ +     E L+     +    + ++    EL+     L+   A  E Q    L ER
Sbjct: 1050 KSVEEKLSLAQEDLISNRNQIGNQNKLIQ----ELKTAKATLEQDSAKKEQQ----LQER 1101

Query: 1142 ERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERA 1201
             + +QD  +++ L+E  + L +E  +    LAE+   +   + E  +L   L   +LE  
Sbjct: 1102 CKALQDIQKEKSLKE--KELVNEKSK----LAEIEEIKCRQEKEITKLNEELKSHKLESI 1155

Query: 1202 QLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLE 1261
            +   +   L+++ Q L      L  + + L +    QE+ N+Q+L +   + +E  EL +
Sbjct: 1156 K---EITNLKDAKQLLIQQKLELQGKADSL-KAAVEQEKRNQQILKD--QVKKEEEELKK 1209

Query: 1262 RSLESRDHLHREQRE 1276
              +E    LH E +E
Sbjct: 1210 EFIEKEAKLHSEIKE 1224



 Score =  110 bits (275), Expect = 1e-23
 Identities = 213/1072 (19%), Positives = 436/1072 (40%), Gaps = 99/1072 (9%)

Query: 219  ERDLGAQRL------AELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQ 272
            ++DL  Q+L      +E  L R  + L  +  +    +     +  +  + KA+ ++L+Q
Sbjct: 341  QKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQ 400

Query: 273  ELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRL 332
            + EEK +  L  Q+E+  L +++  L  E Q      +  E  +  +E L ++  ++  L
Sbjct: 401  QREEKEQHGLQLQSEINQLHSKL--LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADL 458

Query: 333  QEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENL 392
            Q +L R  E+L+      ++L+ +      L+ +K   +EQ    +   A+L E Q +  
Sbjct: 459  QLKLSRLEEQLKEKVTNSTELQHQ------LDKTKQQHQEQQALQQSTTAKLREAQNDLE 512

Query: 393  LLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDE 452
             +  ++G+   ++ +L   + +  E    LE E +          GE  +          
Sbjct: 513  QVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHT 572

Query: 453  VREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFD 512
            ++E        L+ ++   +   + L  Q   Q   L A  +D VL +     +     +
Sbjct: 573  LQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRA-AQDRVLSLETSVNELNSQLN 631

Query: 513  HSPQGLVQ-----KARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAM 567
             S + + Q     KA+     + + A  A  + L+   +  Q    D Q+  + +     
Sbjct: 632  ESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLD 691

Query: 568  DPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGR 627
               A     QE  S +E+     K    S  Q    +   +G   K++A  L        
Sbjct: 692  QVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEEL---EGQIKKLEADSL------EV 742

Query: 628  EAPQGELVPEAWGLRQEGPEHKPGPSEPS-SVQLEEQEGPNQGLDLATGQAEAREHDQRL 686
            +A + + + +    RQ   + +   +E S  +++E++   +  LDL           Q+L
Sbjct: 743  KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802

Query: 687  EGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGV-----------AEQEALREEVA 735
                     ++ +Q  +   E    E  I  E L + +            E+EAL  E++
Sbjct: 803  ------TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELS 856

Query: 736  QLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQ-ARRAEAEAHREAEAQAWEQARLR 794
             ++ K   + D L+    + E +N +      +L +  +  + +   + E    EQ  L+
Sbjct: 857  TVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK 916

Query: 795  EAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGR 854
            +++E   +       E  ++ E L  A    +Q E+E           E+++Q   +E +
Sbjct: 917  KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE-----------EQQLQGNINELK 965

Query: 855  QHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQ 914
            Q    +E+++++ EALQ EL+ AV++  EL  +   LQ++L QAA   QE   EKE    
Sbjct: 966  Q---SSEQKKKQIEALQGELKIAVLQKTELENK---LQQQLTQAA---QELAAEKEKISV 1016

Query: 915  RYQGLEQRLEA--ELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQL 972
                 E+  E   +LQ+    +E  L+  +     +EE+L   ++          +    
Sbjct: 1017 LQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLI-------SNRNQ 1069

Query: 973  VETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQG----RAQELLLQ-SQRAQE 1027
            +  QN  + E++ + A L  + A  + QLQ     L  +Q     + +EL+ + S+ A+ 
Sbjct: 1070 IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEI 1129

Query: 1028 HSSRLQAEKSVLEIQGQELHRKLEVLEE--EVRAARQSQEETRGQQQALLRDHKALAQLQ 1085
               + + EK + ++  +    KLE ++E   ++ A+Q   + + + Q      KA  + +
Sbjct: 1130 EEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQE 1189

Query: 1086 RRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQ-RASVEAQEVALLAERERL 1144
            +R +  L+  + +  +             EL+    + +A+  + ++ +EV +    E  
Sbjct: 1190 KRNQQILKDQVKKEEE-------------ELKKEFIEKEAKLHSEIKEKEVGMKKHEENE 1236

Query: 1145 MQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLE 1204
             +   +   L E L  ++ E   +Q  ++EL ++  +L+GE   L   +   + ER  L 
Sbjct: 1237 AKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALL 1296

Query: 1205 MQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQL-LAEVQALSRE 1255
             +  +     ++L      L  + +  T        EN+ L +   QAL+R+
Sbjct: 1297 ERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRK 1348



 Score =  107 bits (266), Expect = 1e-22
 Identities = 154/684 (22%), Positives = 307/684 (44%), Gaps = 93/684 (13%)

Query: 706  LEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDEL---EAQARKLEAQNTEA 762
            L  ++ +GP   + +A  V E + L+  V +L +K + L + L   E    KLE ++ E 
Sbjct: 272  LRSELAKGP---QEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEE 328

Query: 763  ARLSKELAQARRAEAEA---HREAEAQAWEQARLREAVEA-----AGQELESASQEREAL 814
            + +SK+  QA   + +      ++   A E +  R  VE      A Q+L+    E E  
Sbjct: 329  S-VSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETK 387

Query: 815  VEALAAAGRERRQW--EREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQA 872
             + L A  ++ +Q   E+E   L+ QSE  +   ++LE+E  + L EA    +E+  L +
Sbjct: 388  YQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE--RQLGEAHGRLKEQRQLSS 445

Query: 873  E-LEKAVVRGKELGARLEHLQRELEQA---ALERQEFLREKESQHQRYQGLEQRLEAELQ 928
            E L     +  +L  +L  L+ +L++    + E Q  L + + QHQ  Q L+Q   A+L+
Sbjct: 446  EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLR 505

Query: 929  AAATSKEEALMEL--KTRALQLEEELFQLRQGPAGLGPKKR----AEPQLVETQNVRLIE 982
             A    E+ L ++  K + +Q  E L Q  +    L  K+R    A+ Q  E +   L +
Sbjct: 506  EAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ 565

Query: 983  VERSNAMLVAEKAALQGQLQ-----HLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKS 1037
            ++  N  L  +   L  +L+     H + Q  +L  + QE     + AQ+    L+   +
Sbjct: 566  LQEKNHTLQEQVTQLTEKLKNQSESHKQAQ-ENLHDQVQEQKAHLRAAQDRVLSLETSVN 624

Query: 1038 VLEIQGQELHRKLEVLEEEVRAARQ---SQEETRGQQQALLRDHKALAQ--LQRRQE--- 1089
             L  Q  E   K+  L+ +++A  +   S E  +  Q+A L++H   AQ  LQ +Q+   
Sbjct: 625  ELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELN 684

Query: 1090 ---AELEGLLVRHRD-------LKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLA 1139
                +L+ +  + +D       L+++++  +  +  L+ + E+L+ Q   +EA  + + A
Sbjct: 685  KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKA 744

Query: 1140 ERERLMQDGHRQRGLEEEL--------RRLQSEHDRAQMLLAELSRERGELQGERGELRG 1191
             +E+ +QD  +QR L  +L        ++L+ E +       +L ++   L+  + +L  
Sbjct: 745  SKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTK 804

Query: 1192 RLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCE--------LLTQL--------- 1234
            +    ++ +   E  SQ+ +  +++L+       T+ +        L+T+L         
Sbjct: 805  QEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSK 864

Query: 1235 --------RSAQEEENRQLLAEVQALSRENREL-------LERSLESRDHLHREQREYLD 1279
                    +S  E+EN++  A +  L +  +EL       +E +L+ +  L +   +  +
Sbjct: 865  VSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKE 924

Query: 1280 QLNALRREKQKLVEKIMDQYRVLE 1303
              + L+ E   + E+++     L+
Sbjct: 925  ASHQLKLELNSMQEQLIQAQNTLK 948



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 142/648 (21%), Positives = 273/648 (42%), Gaps = 92/648 (14%)

Query: 721  ASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAH 780
            AS  A    LR E+A+  ++      EL+    KL++   E  + ++ L +    + + +
Sbjct: 263  ASSEATISQLRSELAKGPQEVAVYVQELQ----KLKSSVNELTQKNQTLTENLLKKEQDY 318

Query: 781  REAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAA-GRERRQWEREGS---RLR 836
             + E +  E++  ++ ++A   + +   Q+ ++ + A   +  R   +   +G    +L+
Sbjct: 319  TKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLK 378

Query: 837  AQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELE 896
             +    E + Q L++E +Q  ++ E + +    LQ+E+ +   +  E   +L      L+
Sbjct: 379  EELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLK 438

Query: 897  QAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMEL-KTRALQLEEELFQ- 954
            +      E L +KE Q    Q    RLE +L+   T+  E   +L KT+    E++  Q 
Sbjct: 439  EQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQ 498

Query: 955  ------------LRQGPAGLGPKKRAEPQL-----VETQNVRLIEVERSNA--------- 988
                        L Q    +G K +    L        +N+ L+E ER +          
Sbjct: 499  STTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEG 558

Query: 989  ------MLVAEKAALQGQLQHLEGQL---GSLQGRAQELL---LQSQRAQEHSSR---LQ 1033
                   L  +   LQ Q+  L  +L        +AQE L   +Q Q+A   +++   L 
Sbjct: 559  ETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLS 618

Query: 1034 AEKSVLEIQGQ--ELHRKLEVLEEEVRAARQ---SQEETRGQQQALLRDHKALAQ--LQR 1086
             E SV E+  Q  E   K+  L+ +++A  +   S E  +  Q+A L++H   AQ  LQ 
Sbjct: 619  LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD 678

Query: 1087 RQE------AELEGLLVRHRD-------LKANMRALELAHRELQGRHEQLQAQRASVEAQ 1133
            +Q+       +L+ +  + +D       L+++++  +  +  L+ + E+L+ Q   +EA 
Sbjct: 679  KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD 738

Query: 1134 EVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRL 1193
             + + A +E+ +QD  +QR L  +L        RA  L  +L  E+  +   R +L+ + 
Sbjct: 739  SLEVKASKEQALQDLQQQRQLNTDLEL------RATELSKQLEMEKEIVSSTRLDLQKKS 792

Query: 1194 ARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEE--NR--QLLAEV 1249
              LE  + +L  Q ++ +   Q             E L+Q    Q EE  NR    + E+
Sbjct: 793  EALESIKQKLTKQEEEKQILKQDF-----------ETLSQETKIQHEELNNRIQTTVTEL 841

Query: 1250 QALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMD 1297
            Q +  E   L+      +D L +      +  +   +E QK    I+D
Sbjct: 842  QKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILD 889



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 85/459 (18%), Positives = 193/459 (42%), Gaps = 42/459 (9%)

Query: 846  MQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEF 905
            +Q    E + + EE ++E  + + LQ +  K      +  A L+ L+++LE+A  E    
Sbjct: 95   LQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNI 154

Query: 906  LREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPK 965
             + K+   Q+   L   + A++++    +       + +  +L EEL             
Sbjct: 155  KQMKDLFEQKAAQLATEI-ADIKSKYDEERSLREAAEQKVTRLTEEL------------- 200

Query: 966  KRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRA 1025
               E  +++     L++      + V +K  +Q Q          +     E   +S++ 
Sbjct: 201  -NKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTL--------MDNMTLERERESEKL 251

Query: 1026 QEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQ 1085
            ++   +LQ++ +  E    +L  +L    +EV    Q  ++ +     L + ++ L +  
Sbjct: 252  KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL 311

Query: 1086 RRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLM 1145
             ++E +   L  +H +   + + ++    +     +QLQ++   + A E +L      L 
Sbjct: 312  LKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSR---LSASETSLHRIHVELS 368

Query: 1146 QDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEM 1205
            + G   + L+EEL  +++++   +    +L ++R E +    +L+  + +L         
Sbjct: 369  EKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH-------- 420

Query: 1206 QSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLE 1265
               +L E+ +QL  +  RL  Q +L ++    +E++   L  ++  L  + +E +  S E
Sbjct: 421  --SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTE 478

Query: 1266 SRDHL------HREQREYLDQLNALRREKQKLVEKIMDQ 1298
             +  L      H+EQ+       A  RE Q  +E+++ Q
Sbjct: 479  LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQ 517



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 143/723 (19%), Positives = 293/723 (40%), Gaps = 94/723 (13%)

Query: 202  LEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLA 261
            LE  +  L G + KL  +  L  +   E  L+     L+ +       E  +  L+ QL 
Sbjct: 721  LEQKTEELEGQIKKLEAD-SLEVKASKEQALQD----LQQQRQLNTDLELRATELSKQLE 775

Query: 262  NAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEA 321
              K  +   R +L++K+E L   + ++   E E + L+Q+ + LS + K   +  EE   
Sbjct: 776  MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETK---IQHEELN- 831

Query: 322  LRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEE-RVLSGVLEASKALLEEQLEAARER 380
                  R+     EL++ +   +A     S ++++   +S  L+ SK+  E++ +  +  
Sbjct: 832  -----NRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAA 886

Query: 381  CARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEA 440
               L +T +E                 L+HQ+    E  ++ + EL++SLE    +  + 
Sbjct: 887  ILDLEKTCKE-----------------LKHQLQVQMENTLKEQKELKKSLEKEKEASHQL 929

Query: 441  PLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPV 500
             L     S+Q+++ +A+   L+  E+E ++L+G +  L+     +   +EA + +  + V
Sbjct: 930  KL--ELNSMQEQLIQAQ-NTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAV 986

Query: 501  LEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAES 560
            L++        +   Q L Q A++   +   ++   L +  E S E  +   SD    ES
Sbjct: 987  LQKTELE----NKLQQQLTQAAQELAAEKEKIS--VLQNNYEKSQETFKQLQSDFYGRES 1040

Query: 561  PLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLL 620
             L A   D ++ +   + S +  +   +  + G ++ L      A         +  Q L
Sbjct: 1041 ELLATRQDLKSVE--EKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQL 1098

Query: 621  GGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAR 680
                +  +  Q          +++  + K   +E S +   E+    Q  ++     E +
Sbjct: 1099 QERCKALQDIQ----------KEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELK 1148

Query: 681  EHDQRLEG-----TVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVA 735
             H  +LE       ++D      QQK    LE+Q                + ++L+  V 
Sbjct: 1149 SH--KLESIKEITNLKDAKQLLIQQK----LELQ---------------GKADSLKAAVE 1187

Query: 736  QLRRKAEALGDELEAQARKLEAQNTE-AARLSKELAQARRAEAEAHREAEAQAWEQARLR 794
            Q +R  + L D+++ +  +L+ +  E  A+L  E+ + +    + H E E      A+L 
Sbjct: 1188 QEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKE-KEVGMKKHEENE------AKLT 1240

Query: 795  EAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGR 854
              + A  + L +  +E +       ++ R   + E++   LR +    E  +Q  + E R
Sbjct: 1241 MQITALNENLGTVKKEWQ-------SSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERR 1293

Query: 855  QHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQ 914
              LE   +   E E LQ ++ +   +     A ++ L RE +   ++  + L  K ++  
Sbjct: 1294 ALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDN 1353

Query: 915  RYQ 917
              Q
Sbjct: 1354 EVQ 1356



 Score = 54.7 bits (130), Expect = 7e-07
 Identities = 84/408 (20%), Positives = 166/408 (40%), Gaps = 41/408 (10%)

Query: 926  ELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVER 985
            +LQA+   ++    ELK + L+  + L Q    P GL     AE Q +E Q   L E + 
Sbjct: 94   DLQASLKEEKWYSEELK-KELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQ---LEEAQT 149

Query: 986  SNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQE 1045
             N  +   K   + +   L  ++  ++ +  E         E S R  AE+ V  +  +E
Sbjct: 150  ENFNIKQMKDLFEQKAAQLATEIADIKSKYDE---------ERSLREAAEQKVTRLT-EE 199

Query: 1046 LHRKLEVLEE--EVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLK 1103
            L+++  V+++       R   E+    ++ L++    +  +   +E E E L    + L+
Sbjct: 200  LNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQ 259

Query: 1104 ANMRALELAHRELQGRH-----------EQLQAQRASVEAQEVALLAERERLMQDGHRQR 1152
            +   + E    +L+              ++LQ  ++SV           E L++      
Sbjct: 260  SQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYT 319

Query: 1153 GLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRE 1212
             LEE+           Q  L +   +  +LQ         L R+ +E ++    +Q+L+E
Sbjct: 320  KLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKE 379

Query: 1213 SNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHR 1272
               +++     L  + + L Q R  +E+   QL +E+  L   + +LLE           
Sbjct: 380  ELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL---HSKLLET---------- 426

Query: 1273 EQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRTKKGSWLADKV 1320
             +R+  +    L+ ++Q   EK+MD+ + +  + L  ++    L +KV
Sbjct: 427  -ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKV 473


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.129    0.353 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,646,954
Number of Sequences: 37866
Number of extensions: 3438970
Number of successful extensions: 50038
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 598
Number of HSP's successfully gapped in prelim test: 1659
Number of HSP's that attempted gapping in prelim test: 20243
Number of HSP's gapped (non-prelim): 14735
length of query: 1476
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1361
effective length of database: 13,892,928
effective search space: 18908275008
effective search space used: 18908275008
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.