Guide to the Human Genome
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Search of human proteins with 83921614

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|83921614 cytochrome b5 outer mitochondrial membrane
precursor [Homo sapiens]
         (150 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|83921614 cytochrome b5 outer mitochondrial membrane precursor...   307   2e-84
gi|41281768 cytochrome b-5 isoform 1 [Homo sapiens]                   139   7e-34
gi|4503183 cytochrome b-5 isoform 2 [Homo sapiens]                    119   1e-27
gi|214831730 fatty acid desaturase 1 [Homo sapiens]                    63   8e-11
gi|4758334 fatty acid desaturase 2 [Homo sapiens]                      63   8e-11
gi|84875541 cytochrome b5 reductase 4 [Homo sapiens]                   58   3e-09
gi|74099704 sulfite oxidase [Homo sapiens]                             58   3e-09
gi|74099702 sulfite oxidase [Homo sapiens]                             58   3e-09
gi|74099694 sulfite oxidase [Homo sapiens]                             58   3e-09
gi|205360949 fatty acid 2-hydroxylase [Homo sapiens]                   57   8e-09
gi|13375616 fatty acid desaturase 3 [Homo sapiens]                     47   5e-06
gi|126032348 hect domain and RLD 2 [Homo sapiens]                      42   2e-04
gi|40255060 cytochrome b5 domain containing 1 [Homo sapiens]           39   0.002
gi|4755125 aquaporin 4 isoform b [Homo sapiens]                        35   0.018
gi|4502181 aquaporin 4 isoform a [Homo sapiens]                        35   0.018
gi|4502183 aquaporin 5 [Homo sapiens]                                  32   0.26 
gi|4502179 aquaporin 2 [Homo sapiens]                                  31   0.45 
gi|45446752 aquaporin 8 [Homo sapiens]                                 30   1.00 
gi|118026942 zinc finger protein Cezanne [Homo sapiens]                29   1.7  
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa...    29   1.7  
gi|74027261 serine peptidase inhibitor, Kazal type 5 isoform b p...    28   2.2  
gi|189163501 serine peptidase inhibitor, Kazal type 5 isoform a ...    28   2.2  
gi|6912506 major intrinsic protein of lens fiber [Homo sapiens]        28   3.8  
gi|86792455 aquaporin 6 [Homo sapiens]                                 28   3.8  
gi|147904948 calcium channel, voltage-dependent, beta 2 subunit ...    27   6.5  
gi|45359842 calcium channel, voltage-dependent, beta 2 subunit i...    27   6.5  

>gi|83921614 cytochrome b5 outer mitochondrial membrane precursor
           [Homo sapiens]
          Length = 150

 Score =  307 bits (787), Expect = 2e-84
 Identities = 150/150 (100%), Positives = 150/150 (100%)

Query: 1   MSGSMATAEASGSDGKGQEVETSVTYYRLEEVAKRNSLKELWLVIHGRVYDVTRFLNEHP 60
           MSGSMATAEASGSDGKGQEVETSVTYYRLEEVAKRNSLKELWLVIHGRVYDVTRFLNEHP
Sbjct: 1   MSGSMATAEASGSDGKGQEVETSVTYYRLEEVAKRNSLKELWLVIHGRVYDVTRFLNEHP 60

Query: 61  GGEEVLLEQAGVDASESFEDVGHSSDAREMLKQYYIGDIHPSDLKPESGSKDPSKNDTCK 120
           GGEEVLLEQAGVDASESFEDVGHSSDAREMLKQYYIGDIHPSDLKPESGSKDPSKNDTCK
Sbjct: 61  GGEEVLLEQAGVDASESFEDVGHSSDAREMLKQYYIGDIHPSDLKPESGSKDPSKNDTCK 120

Query: 121 SCWAYWILPIIGAVLLGFLYRYYTSESKSS 150
           SCWAYWILPIIGAVLLGFLYRYYTSESKSS
Sbjct: 121 SCWAYWILPIIGAVLLGFLYRYYTSESKSS 150


>gi|41281768 cytochrome b-5 isoform 1 [Homo sapiens]
          Length = 134

 Score =  139 bits (351), Expect = 7e-34
 Identities = 67/133 (50%), Positives = 93/133 (69%), Gaps = 6/133 (4%)

Query: 18  QEVETSVTYYRLEEVAKRNSLKELWLVIHGRVYDVTRFLNEHPGGEEVLLEQAGVDASES 77
           ++ + +V YY LEE+ K N  K  WL++H +VYD+T+FL EHPGGEEVL EQAG DA+E+
Sbjct: 3   EQSDEAVKYYTLEEIQKHNHSKSTWLILHHKVYDLTKFLEEHPGGEEVLREQAGGDATEN 62

Query: 78  FEDVGHSSDAREMLKQYYIGDIHPSDLKPESGSKDP----SKNDTCKSCWAYWILPIIGA 133
           FEDVGHS+DAREM K + IG++HP D +P+  +K P    +  D+  S W  W++P I A
Sbjct: 63  FEDVGHSTDAREMSKTFIIGELHPDD-RPKL-NKPPETLITTIDSSSSWWTNWVIPAISA 120

Query: 134 VLLGFLYRYYTSE 146
           V +  +YR Y +E
Sbjct: 121 VAVALMYRLYMAE 133


>gi|4503183 cytochrome b-5 isoform 2 [Homo sapiens]
          Length = 98

 Score =  119 bits (297), Expect = 1e-27
 Identities = 52/86 (60%), Positives = 68/86 (79%)

Query: 18  QEVETSVTYYRLEEVAKRNSLKELWLVIHGRVYDVTRFLNEHPGGEEVLLEQAGVDASES 77
           ++ + +V YY LEE+ K N  K  WL++H +VYD+T+FL EHPGGEEVL EQAG DA+E+
Sbjct: 3   EQSDEAVKYYTLEEIQKHNHSKSTWLILHHKVYDLTKFLEEHPGGEEVLREQAGGDATEN 62

Query: 78  FEDVGHSSDAREMLKQYYIGDIHPSD 103
           FEDVGHS+DAREM K + IG++HP D
Sbjct: 63  FEDVGHSTDAREMSKTFIIGELHPDD 88


>gi|214831730 fatty acid desaturase 1 [Homo sapiens]
          Length = 501

 Score = 63.2 bits (152), Expect = 8e-11
 Identities = 32/91 (35%), Positives = 52/91 (57%), Gaps = 4/91 (4%)

Query: 26  YYRLEEVAKRNSLKELWLVIHGRVYDVTRFLNEHPGGEEVLLEQAGVDASESFEDVGHSS 85
           Y+  +EVA+R+  +E WLVI  +VY+++ F   HPGG  V+   AG DA++ F     + 
Sbjct: 76  YFTWDEVAQRSGCEERWLVIDRKVYNISEFTRRHPGGSRVISHYAGQDATDPFV----AF 131

Query: 86  DAREMLKQYYIGDIHPSDLKPESGSKDPSKN 116
              + L + Y+  +   +L PE  S +P+KN
Sbjct: 132 HINKGLVKKYMNSLLIGELSPEQPSFEPTKN 162


>gi|4758334 fatty acid desaturase 2 [Homo sapiens]
          Length = 444

 Score = 63.2 bits (152), Expect = 8e-11
 Identities = 39/107 (36%), Positives = 59/107 (55%), Gaps = 7/107 (6%)

Query: 12  GSDGKGQ-EVETSVTYYRLEEVAKRNSLKELWLVIHGRVYDVTRFLNEHPGGEEVLLEQA 70
           G+ G+G  E E SV  +  EE+ K N   + WLVI  +VY++T++  +HPGG+ V+   A
Sbjct: 5   GNQGEGAAEREVSVPTFSWEEIQKHNLRTDRWLVIDRKVYNITKWSIQHPGGQRVIGHYA 64

Query: 71  GVDASESFEDVGHSSD-AREMLKQYYIGDIHPSDLKPESGSKDPSKN 116
           G DA+++F       +   + LK   IG     +L PE  S+D  KN
Sbjct: 65  GEDATDAFRAFHPDLEFVGKFLKPLLIG-----ELAPEEPSQDHGKN 106


>gi|84875541 cytochrome b5 reductase 4 [Homo sapiens]
          Length = 521

 Score = 58.2 bits (139), Expect = 3e-09
 Identities = 30/78 (38%), Positives = 45/78 (57%), Gaps = 2/78 (2%)

Query: 30  EEVAKRNSLKELWLVIHGRVYDVTRFLNEHPGGEEVLLEQAGVDASESFEDVGHSSDARE 89
           EE+ K N   + W+ I G VY+V+ ++  HPGGE+ L+  AG D +E F+ V    +   
Sbjct: 60  EELKKHNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGSDGTELFDQVHRWVNYES 119

Query: 90  MLKQYYIG--DIHPSDLK 105
           MLK+  +G   I P+ LK
Sbjct: 120 MLKECLVGRMAIKPAVLK 137


>gi|74099704 sulfite oxidase [Homo sapiens]
          Length = 545

 Score = 57.8 bits (138), Expect = 3e-09
 Identities = 35/108 (32%), Positives = 58/108 (53%), Gaps = 4/108 (3%)

Query: 14  DGKGQEVETSVTYYRLEEVAKRNSLKE-LWLVIHGRVYDVTRFLNEHPGGEEVLLEQAG- 71
           D + +  + S   Y  EEV+   S +  +W+ +   V+DVT F++ HPGG   L+  AG 
Sbjct: 72  DHRCRAAQESTHIYTKEEVSSHTSPETGIWVTLGSEVFDVTEFVDLHPGGPSKLMLAAGG 131

Query: 72  -VDASESFEDVGHSSDAREMLKQYYIGDIHPSD-LKPESGSKDPSKND 117
            ++   +   V + S  RE+L QY IG+++P D + P   + DP  +D
Sbjct: 132 PLEPFWALYAVHNQSHVRELLAQYKIGELNPEDKVAPTVETSDPYADD 179


>gi|74099702 sulfite oxidase [Homo sapiens]
          Length = 545

 Score = 57.8 bits (138), Expect = 3e-09
 Identities = 35/108 (32%), Positives = 58/108 (53%), Gaps = 4/108 (3%)

Query: 14  DGKGQEVETSVTYYRLEEVAKRNSLKE-LWLVIHGRVYDVTRFLNEHPGGEEVLLEQAG- 71
           D + +  + S   Y  EEV+   S +  +W+ +   V+DVT F++ HPGG   L+  AG 
Sbjct: 72  DHRCRAAQESTHIYTKEEVSSHTSPETGIWVTLGSEVFDVTEFVDLHPGGPSKLMLAAGG 131

Query: 72  -VDASESFEDVGHSSDAREMLKQYYIGDIHPSD-LKPESGSKDPSKND 117
            ++   +   V + S  RE+L QY IG+++P D + P   + DP  +D
Sbjct: 132 PLEPFWALYAVHNQSHVRELLAQYKIGELNPEDKVAPTVETSDPYADD 179


>gi|74099694 sulfite oxidase [Homo sapiens]
          Length = 545

 Score = 57.8 bits (138), Expect = 3e-09
 Identities = 35/108 (32%), Positives = 58/108 (53%), Gaps = 4/108 (3%)

Query: 14  DGKGQEVETSVTYYRLEEVAKRNSLKE-LWLVIHGRVYDVTRFLNEHPGGEEVLLEQAG- 71
           D + +  + S   Y  EEV+   S +  +W+ +   V+DVT F++ HPGG   L+  AG 
Sbjct: 72  DHRCRAAQESTHIYTKEEVSSHTSPETGIWVTLGSEVFDVTEFVDLHPGGPSKLMLAAGG 131

Query: 72  -VDASESFEDVGHSSDAREMLKQYYIGDIHPSD-LKPESGSKDPSKND 117
            ++   +   V + S  RE+L QY IG+++P D + P   + DP  +D
Sbjct: 132 PLEPFWALYAVHNQSHVRELLAQYKIGELNPEDKVAPTVETSDPYADD 179


>gi|205360949 fatty acid 2-hydroxylase [Homo sapiens]
          Length = 372

 Score = 56.6 bits (135), Expect = 8e-09
 Identities = 27/71 (38%), Positives = 44/71 (61%), Gaps = 2/71 (2%)

Query: 31 EVAKRNSLKELWLVIHGRVYDVTRFLNEHPGGEEVLLEQAGVDASESFEDV--GHSSDAR 88
          EV +R +    W+    R+YD++ F+  HPGGE++L  +AG D S   +     HS++AR
Sbjct: 15 EVQRRLAAGACWVRRGARLYDLSSFVRHHPGGEQLLRARAGQDISADLDGPPHRHSANAR 74

Query: 89 EMLKQYYIGDI 99
            L+QYY+G++
Sbjct: 75 RWLEQYYVGEL 85


>gi|13375616 fatty acid desaturase 3 [Homo sapiens]
          Length = 445

 Score = 47.4 bits (111), Expect = 5e-06
 Identities = 22/75 (29%), Positives = 40/75 (53%), Gaps = 1/75 (1%)

Query: 30  EEVAKRNSLKELWLVIHGRVYDVTRFLNEHPGGEEVLLEQAGVDASESFEDVGHSSD-AR 88
           E++   +   + WLVI  RVYD++R+   HPGG  ++      DA+++F       +  R
Sbjct: 26  EQIRAHDQPGDKWLVIERRVYDISRWAQRHPGGSRLIGHHGAEDATDAFRAFHQDLNFVR 85

Query: 89  EMLKQYYIGDIHPSD 103
           + L+   IG++ P +
Sbjct: 86  KFLQPLLIGELAPEE 100


>gi|126032348 hect domain and RLD 2 [Homo sapiens]
          Length = 4834

 Score = 42.0 bits (97), Expect = 2e-04
 Identities = 28/99 (28%), Positives = 41/99 (41%), Gaps = 4/99 (4%)

Query: 24   VTYYRLEEVAKRNSLKELWLVIHGRVYDVTRFLNEHPGGEEVLLEQAGVDASESFEDVGH 83
            VT  R  ++   N     W VI G+VYD+  F  +   G  +L + AG D   + E    
Sbjct: 1207 VTLIRKADLENHNKDGGFWTVIDGKVYDIKDFQTQSLTGNSILAQFAGEDPVVALEAALQ 1266

Query: 84   SSDAREMLKQYYIGDIHPSDLK----PESGSKDPSKNDT 118
              D RE +  + +G     D +    P+ GS      DT
Sbjct: 1267 FEDTRESMHAFCVGQYLEPDQEIVTIPDLGSLSSPLIDT 1305


>gi|40255060 cytochrome b5 domain containing 1 [Homo sapiens]
          Length = 228

 Score = 38.9 bits (89), Expect = 0.002
 Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 2/56 (3%)

Query: 26 YYRLEEVAKRNSLKELWLVIHGRVYDVTRFLNEHPGG--EEVLLEQAGVDASESFE 79
          Y+   EVA+ N  ++LW+   GRVYD+T    E+ G    + ++E AG D S  F+
Sbjct: 19 YFTPAEVAQHNRPEDLWVSYLGRVYDLTSLAQEYKGNLLLKPIVEVAGQDISHWFD 74


>gi|4755125 aquaporin 4 isoform b [Homo sapiens]
          Length = 301

 Score = 35.4 bits (80), Expect = 0.018
 Identities = 14/20 (70%), Positives = 15/20 (75%)

Query: 123 WAYWILPIIGAVLLGFLYRY 142
           W YW+ PIIGAVL G LY Y
Sbjct: 209 WIYWVGPIIGAVLAGGLYEY 228


>gi|4502181 aquaporin 4 isoform a [Homo sapiens]
          Length = 323

 Score = 35.4 bits (80), Expect = 0.018
 Identities = 14/20 (70%), Positives = 15/20 (75%)

Query: 123 WAYWILPIIGAVLLGFLYRY 142
           W YW+ PIIGAVL G LY Y
Sbjct: 231 WIYWVGPIIGAVLAGGLYEY 250


>gi|4502183 aquaporin 5 [Homo sapiens]
          Length = 265

 Score = 31.6 bits (70), Expect = 0.26
 Identities = 11/20 (55%), Positives = 14/20 (70%)

Query: 123 WAYWILPIIGAVLLGFLYRY 142
           W +W+ PI+GAVL   LY Y
Sbjct: 204 WVFWVGPIVGAVLAAILYFY 223


>gi|4502179 aquaporin 2 [Homo sapiens]
          Length = 271

 Score = 30.8 bits (68), Expect = 0.45
 Identities = 10/20 (50%), Positives = 14/20 (70%)

Query: 123 WAYWILPIIGAVLLGFLYRY 142
           W +WI P++GA+L   LY Y
Sbjct: 202 WVFWIGPLVGAILGSLLYNY 221


>gi|45446752 aquaporin 8 [Homo sapiens]
          Length = 261

 Score = 29.6 bits (65), Expect = 1.00
 Identities = 9/27 (33%), Positives = 17/27 (62%)

Query: 123 WAYWILPIIGAVLLGFLYRYYTSESKS 149
           W YW+ P++  +L+G L R +  + K+
Sbjct: 228 WIYWLGPLLAGLLVGLLIRCFIGDGKT 254


>gi|118026942 zinc finger protein Cezanne [Homo sapiens]
          Length = 843

 Score = 28.9 bits (63), Expect = 1.7
 Identities = 19/65 (29%), Positives = 27/65 (41%), Gaps = 7/65 (10%)

Query: 51  DVTRFLNEHPGGEEVLLEQAGVDASESFEDVGHSSDAREMLKQYYIGDIHPSDLKPESGS 110
           D  R     PG    LLE    D + +  D        E L+Q + G++ PS  +   GS
Sbjct: 11  DFVRSTGAEPGLARDLLEGKNWDVNAALSDF-------EQLRQVHAGNLPPSFSEGSGGS 63

Query: 111 KDPSK 115
           + P K
Sbjct: 64  RTPEK 68


>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
           sapiens]
          Length = 332

 Score = 28.9 bits (63), Expect = 1.7
 Identities = 17/57 (29%), Positives = 32/57 (56%), Gaps = 1/57 (1%)

Query: 46  HGRVYDVTRFLNEHPGGEEVLLEQAGVDASESFEDVGHSSDAREMLKQYYIGDIHPS 102
           + +V +V +   E  G  ++L+  AG+  S  FED+  S+  R ++   Y+G ++PS
Sbjct: 98  YNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFER-LMSINYLGSVYPS 153


>gi|74027261 serine peptidase inhibitor, Kazal type 5 isoform b
            precursor [Homo sapiens]
          Length = 1064

 Score = 28.5 bits (62), Expect = 2.2
 Identities = 20/54 (37%), Positives = 25/54 (46%), Gaps = 9/54 (16%)

Query: 73   DASESFEDVGHSSDAREMLKQYY----IGDIHPSDLKPESGSKDPSKNDTCKSC 122
            D+ +SF     SS   EM K Y     IG + P DLKP  G    + N+ C  C
Sbjct: 980  DSPDSF-----SSLDSEMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLC 1028


>gi|189163501 serine peptidase inhibitor, Kazal type 5 isoform a
            precursor [Homo sapiens]
          Length = 1094

 Score = 28.5 bits (62), Expect = 2.2
 Identities = 20/54 (37%), Positives = 25/54 (46%), Gaps = 9/54 (16%)

Query: 73   DASESFEDVGHSSDAREMLKQYY----IGDIHPSDLKPESGSKDPSKNDTCKSC 122
            D+ +SF     SS   EM K Y     IG + P DLKP  G    + N+ C  C
Sbjct: 1010 DSPDSF-----SSLDSEMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLC 1058


>gi|6912506 major intrinsic protein of lens fiber [Homo sapiens]
          Length = 263

 Score = 27.7 bits (60), Expect = 3.8
 Identities = 17/62 (27%), Positives = 23/62 (37%), Gaps = 4/62 (6%)

Query: 81  VGHSSDAREMLKQYYIGDIHPSDLKPESGSKDPSKNDTCKSCWAYWILPIIGAVLLGFLY 140
           VG S     +   YY G    + + P              + W YW+ PIIG  L   LY
Sbjct: 164 VGFSLALGHLFGMYYTG----AGMNPARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLLY 219

Query: 141 RY 142
            +
Sbjct: 220 DF 221


>gi|86792455 aquaporin 6 [Homo sapiens]
          Length = 282

 Score = 27.7 bits (60), Expect = 3.8
 Identities = 7/20 (35%), Positives = 14/20 (70%)

Query: 123 WAYWILPIIGAVLLGFLYRY 142
           W +W+ P++GA+L   +Y +
Sbjct: 214 WVFWVGPLMGALLASLIYNF 233


>gi|147904948 calcium channel, voltage-dependent, beta 2 subunit
           isoform 8 [Homo sapiens]
          Length = 608

 Score = 26.9 bits (58), Expect = 6.5
 Identities = 13/34 (38%), Positives = 18/34 (52%), Gaps = 3/34 (8%)

Query: 96  IGDIHPSDLK---PESGSKDPSKNDTCKSCWAYW 126
           +GDI PS  K   P SG+K   + D  K+   +W
Sbjct: 180 LGDIVPSSRKSTPPSSGAKSADEQDQWKTAGLFW 213


>gi|45359842 calcium channel, voltage-dependent, beta 2 subunit
           isoform 4 [Homo sapiens]
          Length = 636

 Score = 26.9 bits (58), Expect = 6.5
 Identities = 13/34 (38%), Positives = 18/34 (52%), Gaps = 3/34 (8%)

Query: 96  IGDIHPSDLK---PESGSKDPSKNDTCKSCWAYW 126
           +GDI PS  K   P SG+K   + D  K+   +W
Sbjct: 208 LGDIVPSSRKSTPPSSGAKSADEQDQWKTAGLFW 241


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.131    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,853,428
Number of Sequences: 37866
Number of extensions: 247588
Number of successful extensions: 405
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 379
Number of HSP's gapped (non-prelim): 26
length of query: 150
length of database: 18,247,518
effective HSP length: 93
effective length of query: 57
effective length of database: 14,725,980
effective search space: 839380860
effective search space used: 839380860
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 57 (26.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
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