BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|83745141 bubblegum-related acyl-CoA synthetase 2 [Homo sapiens] (666 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|83745141 bubblegum-related acyl-CoA synthetase 2 [Homo sapiens] 1345 0.0 gi|27477105 lipidosin [Homo sapiens] 642 0.0 gi|42794760 acyl-CoA synthetase long-chain family member 5 isofo... 159 1e-38 gi|42794758 acyl-CoA synthetase long-chain family member 5 isofo... 159 1e-38 gi|42794756 acyl-CoA synthetase long-chain family member 5 isofo... 159 1e-38 gi|40807491 acyl-CoA synthetase long-chain family member 1 [Homo... 155 1e-37 gi|4758332 acyl-CoA synthetase long-chain family member 4 isofor... 149 6e-36 gi|12669909 acyl-CoA synthetase long-chain family member 4 isofo... 149 6e-36 gi|57165412 acyl-CoA synthetase long-chain family member 6 isofo... 141 2e-33 gi|57165410 acyl-CoA synthetase long-chain family member 6 isofo... 141 2e-33 gi|42794754 acyl-CoA synthetase long-chain family member 3 [Homo... 137 4e-32 gi|42794752 acyl-CoA synthetase long-chain family member 3 [Homo... 137 4e-32 gi|156151445 acyl-CoA synthetase family member 2 [Homo sapiens] 82 2e-15 gi|187761345 acyl-CoA synthetase family member 3 [Homo sapiens] 75 3e-13 gi|187761343 acyl-CoA synthetase family member 3 [Homo sapiens] 75 3e-13 gi|157311624 acyl-CoA synthetase medium-chain family member 2B [... 53 1e-06 gi|157311622 acyl-CoA synthetase medium-chain family member 2B [... 53 1e-06 gi|239756507 PREDICTED: similar to Acyl-coenzyme A synthetase AC... 50 7e-06 gi|239756505 PREDICTED: similar to Acyl-coenzyme A synthetase AC... 50 7e-06 gi|58082049 acyl-CoA synthetase medium-chain family member 2A [H... 47 6e-05 gi|227499619 solute carrier family 27 (fatty acid transporter), ... 44 4e-04 gi|13325057 solute carrier family 27 (fatty acid transporter), m... 43 0.001 gi|122937307 acyl-CoA synthetase medium-chain family member 4 [H... 41 0.003 gi|13236579 solute carrier family 27 member 3 [Homo sapiens] 40 0.005 gi|40807357 solute carrier family 27 (fatty acid transporter), m... 39 0.020 gi|115511026 acyl-CoA synthetase medium-chain family member 1 [H... 38 0.026 gi|62865631 solute carrier family 27 (fatty acid transporter), m... 37 0.045 gi|13325055 solute carrier family 27 (fatty acid transporter), m... 37 0.045 gi|28416953 acyl-CoA synthetase short-chain family member 1 [Hom... 36 0.13 gi|42544134 SA hypertension-associated homolog isoform 2 [Homo s... 33 1.1 >gi|83745141 bubblegum-related acyl-CoA synthetase 2 [Homo sapiens] Length = 666 Score = 1345 bits (3481), Expect = 0.0 Identities = 666/666 (100%), Positives = 666/666 (100%) Query: 1 MTGTPKTQEGAKDLEVDMNKTEVTPRLWTTCRDGEVLLRLSKHGPGHETPMTIPEFFRES 60 MTGTPKTQEGAKDLEVDMNKTEVTPRLWTTCRDGEVLLRLSKHGPGHETPMTIPEFFRES Sbjct: 1 MTGTPKTQEGAKDLEVDMNKTEVTPRLWTTCRDGEVLLRLSKHGPGHETPMTIPEFFRES 60 Query: 61 VNRFGTYPALASKNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFI 120 VNRFGTYPALASKNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFI Sbjct: 61 VNRFGTYPALASKNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFI 120 Query: 121 TAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKA 180 TAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKA Sbjct: 121 TAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKA 180 Query: 181 IIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGV 240 IIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGV Sbjct: 181 IIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGV 240 Query: 241 MLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADA 300 MLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADA Sbjct: 241 MLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADA 300 Query: 301 LKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKK 360 LKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKK Sbjct: 301 LKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKK 360 Query: 361 MLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSLDIPIGELY 420 MLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSLDIPIGELY Sbjct: 361 MLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSLDIPIGELY 420 Query: 421 GLSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESET 480 GLSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESET Sbjct: 421 GLSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESET 480 Query: 481 ETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPII 540 ETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPII Sbjct: 481 ETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPII 540 Query: 541 SNAMLVGDKLKFLSMLLTLKCEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQD 600 SNAMLVGDKLKFLSMLLTLKCEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQD Sbjct: 541 SNAMLVGDKLKFLSMLLTLKCEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQD 600 Query: 601 PLVYKAIQQGINAVNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQ 660 PLVYKAIQQGINAVNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQ Sbjct: 601 PLVYKAIQQGINAVNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQ 660 Query: 661 IDHMYH 666 IDHMYH Sbjct: 661 IDHMYH 666 >gi|27477105 lipidosin [Homo sapiens] Length = 724 Score = 642 bits (1657), Expect = 0.0 Identities = 326/643 (50%), Positives = 446/643 (69%), Gaps = 8/643 (1%) Query: 27 LWTTCRDGEVLLRLSKHGPGHETPMTIPEFFRESVNRFGTYPALASKNGKKWEILNFNQY 86 LWTT DG V LR+ P + P T+ F E+++++G AL K KWE ++++QY Sbjct: 81 LWTTRADGRVRLRIDPSCP--QLPYTVHRMFYEALDKYGDLIALGFKRQDKWEHISYSQY 138 Query: 87 YEACRKAAKSLIKLGLERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNSAEVCQY 146 Y R+AAK +KLGL++ H V ILGFNS EWF +AVG + AGG+ GIY T+S E CQY Sbjct: 139 YLLARRAAKGFLKLGLKQAHSVAILGFNSPEWFFSAVGTVFAGGIVTGIYTTSSPEACQY 198 Query: 147 VITHAKVNILLVENDQQLQKILSIPQSSLEPLKAIIQYRLPM-KKNNNLYSWDDFMELGR 205 + N+++V+ +QL+KIL I L LKA++ Y+ P K N+Y+ ++FMELG Sbjct: 199 IAYDCCANVIMVDTQKQLEKILKI-WKQLPHLKAVVIYKEPPPNKMANVYTMEEFMELGN 257 Query: 206 SIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGVMLSHDNITWIA--GAVTKDFKLTD- 262 +P+ L+ +I++Q+ NQC VL+YTSGTTG PKGVMLS DNITW A G+ D + + Sbjct: 258 EVPEEALDAIIDTQQPNQCCVLVYTSGTTGNPKGVMLSQDNITWTARYGSQAGDIRPAEV 317 Query: 263 KHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADALKGTLVSTLKEVKPTVFIGVPQ 322 + E VVSYLPLSHIAAQ+ D+W I+ GA FA+ DALKG+LV+TL+EV+PT +GVP+ Sbjct: 318 QQEVVVSYLPLSHIAAQIYDLWTGIQWGAQVCFAEPDALKGSLVNTLREVEPTSHMGVPR 377 Query: 323 IWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKKMLGKYNTPVSYRMAKTLVFSKV 382 +WEKI E +++ +A+S +++K +WA ++ + N G P + R+A LV +KV Sbjct: 378 VWEKIMERIQEVAAQSGFIRRKMLLWAMSVTLEQNLT-CPGSDLKPFTTRLADYLVLAKV 436 Query: 383 KTSLGLDHCHSFISGTAPLNQETAEFFLSLDIPIGELYGLSESSGPHTISNQNNYRLLSC 442 + +LG C G AP+ ET FFL L+I + YGLSE+SGPH +S+ NYRL S Sbjct: 437 RQALGFAKCQKNFYGAAPMMAETQHFFLGLNIRLYAGYGLSETSGPHFMSSPYNYRLYSS 496 Query: 443 GKILTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDG 502 GK++ GC+ L Q+ +GIGEICLWGR IFMGYL E +T EAID+EGWLH+GD G+LD Sbjct: 497 GKLVPGCRVKLVNQDAEGIGEICLWGRTIFMGYLNMEDKTCEAIDEEGWLHTGDAGRLDA 556 Query: 503 LGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPIISNAMLVGDKLKFLSMLLTLKCE 562 GFLY+TG +KE++ITAGGENVPP+P+E VK ++PIISNAML+GD+ KFLSMLLTLKC Sbjct: 557 DGFLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISNAMLIGDQRKFLSMLLTLKCT 616 Query: 563 MNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQDPLVYKAIQQGINAVNQEAMNNA 622 ++ + + D L +A+ FC+ +GS+A+TV+EI++++D VY+AI++GI VN A Sbjct: 617 LDPDTSDQTDNLTEQAMEFCQRVGSRATTVSEIIEKKDEAVYQAIEEGIRRVNMNAAARP 676 Query: 623 QRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQIDHMY 665 I+KW ILE+DFSI GGELGP MKLKR V +KYK ID Y Sbjct: 677 YHIQKWAILERDFSISGGELGPTMKLKRLTVLEKYKGIIDSFY 719 >gi|42794760 acyl-CoA synthetase long-chain family member 5 isoform b [Homo sapiens] Length = 683 Score = 159 bits (401), Expect = 1e-38 Identities = 159/639 (24%), Positives = 289/639 (45%), Gaps = 61/639 (9%) Query: 52 TIPEFFRESVNRFGTYPALA-SKNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHG--V 108 T+ E F+ + P L K + + L++ Q + L+ G + V Sbjct: 76 TMYEVFQRGLAVSDNGPCLGYRKPNQPYRWLSYKQVSDRAEYLGSCLLHKGYKSSPDQFV 135 Query: 109 GILGFNSAEWFITAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKIL 168 GI N EW I+ + + V +Y T E +++ A + +++ + Q+ ++ Sbjct: 136 GIFAQNRPEWIISELACYTYSMVAVPLYDTLGPEAIVHIVNKADIAMVICDTPQKALVLI 195 Query: 169 SIPQSSLEPLKAIIQYRLPM---------KKNNNLYSWDDFMELGRSIPDTQLEQVIESQ 219 + P +I P K + S D LG+ + E Sbjct: 196 GNVEKGFTPSLKVIILMDPFDDDLKQRGEKSGIEILSLYDAENLGKEHFRKPVPPSPED- 254 Query: 220 KANQCAVLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDK---HETVVSYLPLSHI 276 +V+ +TSGTTG PKG M++H NI A A K + + + +SYLPL+H+ Sbjct: 255 ----LSVICFTSGTTGDPKGAMITHQNIVSNAAAFLKCVEHAYEPTPDDVAISYLPLAHM 310 Query: 277 AAQMMDIWVPIKIGALTYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSA 336 +++ V GA F Q D L +K +KPT+F VP++ +I++ V+ N A Sbjct: 311 FERIVQA-VVYSCGARVGFFQGDIR--LLADDMKTLKPTLFPAVPRLLNRIYDKVQ-NEA 366 Query: 337 KSMGLKKKAFVWARNIGFKVNSKKMLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFIS 396 K+ LKK A + FK K ++ + L+F+K++ SLG ++ Sbjct: 367 KTP-LKKFLLKLAVSSKFKELQKGIIRHDS------FWDKLIFAKIQDSLG-GRVRVIVT 418 Query: 397 GTAPLNQETAEFF-LSLDIPIGELYGLSESSGPHTISNQNNYRL------LSCGKI-LTG 448 G AP++ FF ++ + E YG +E +G T + ++ L+C + L Sbjct: 419 GAAPMSTSVMTFFRAAMGCQVYEAYGQTECTGGCTFTLPGDWTSGHVGVPLACNYVKLED 478 Query: 449 CKNM-LFQQNKDGIGEICLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLY 507 +M F N +G E+C+ G ++F GYL+ +T EA+D +GWLH+GD+G+ G L Sbjct: 479 VADMNYFTVNNEG--EVCIKGTNVFKGYLKDPEKTQEALDSDGWLHTGDIGRWLPNGTLK 536 Query: 508 VTGHIKEILITAGGENVPPIPVETLVKKKIPIISNAMLVGDKLKFLSMLLTLKCEMNQMS 567 + K I A GE + P +E + + P++ + G+ L+ S++ + + + + Sbjct: 537 IIDRKKNIFKLAQGEYIAPEKIENIYNRSQPVL-QIFVHGESLR-SSLVGVVVPDTDVLP 594 Query: 568 GEPLDKLNFEAINFCRGLGSQASTVTEIVKQQDPLVYKAIQQGINAVNQEA-MNNAQRIE 626 +F LG + S E+ + Q +V +AI + + + +E+ + ++++ Sbjct: 595 ------------SFAAKLGVKGS-FEELCQNQ--VVREAILEDLQKIGKESGLKTFEQVK 639 Query: 627 KWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQIDHMY 665 + + FSI G L P +K KR +++ ++ QID +Y Sbjct: 640 AIFLHPEPFSIENGLLTPTLKAKRGELSKYFRTQIDSLY 678 >gi|42794758 acyl-CoA synthetase long-chain family member 5 isoform b [Homo sapiens] Length = 683 Score = 159 bits (401), Expect = 1e-38 Identities = 159/639 (24%), Positives = 289/639 (45%), Gaps = 61/639 (9%) Query: 52 TIPEFFRESVNRFGTYPALA-SKNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHG--V 108 T+ E F+ + P L K + + L++ Q + L+ G + V Sbjct: 76 TMYEVFQRGLAVSDNGPCLGYRKPNQPYRWLSYKQVSDRAEYLGSCLLHKGYKSSPDQFV 135 Query: 109 GILGFNSAEWFITAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKIL 168 GI N EW I+ + + V +Y T E +++ A + +++ + Q+ ++ Sbjct: 136 GIFAQNRPEWIISELACYTYSMVAVPLYDTLGPEAIVHIVNKADIAMVICDTPQKALVLI 195 Query: 169 SIPQSSLEPLKAIIQYRLPM---------KKNNNLYSWDDFMELGRSIPDTQLEQVIESQ 219 + P +I P K + S D LG+ + E Sbjct: 196 GNVEKGFTPSLKVIILMDPFDDDLKQRGEKSGIEILSLYDAENLGKEHFRKPVPPSPED- 254 Query: 220 KANQCAVLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDK---HETVVSYLPLSHI 276 +V+ +TSGTTG PKG M++H NI A A K + + + +SYLPL+H+ Sbjct: 255 ----LSVICFTSGTTGDPKGAMITHQNIVSNAAAFLKCVEHAYEPTPDDVAISYLPLAHM 310 Query: 277 AAQMMDIWVPIKIGALTYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSA 336 +++ V GA F Q D L +K +KPT+F VP++ +I++ V+ N A Sbjct: 311 FERIVQA-VVYSCGARVGFFQGDIR--LLADDMKTLKPTLFPAVPRLLNRIYDKVQ-NEA 366 Query: 337 KSMGLKKKAFVWARNIGFKVNSKKMLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFIS 396 K+ LKK A + FK K ++ + L+F+K++ SLG ++ Sbjct: 367 KTP-LKKFLLKLAVSSKFKELQKGIIRHDS------FWDKLIFAKIQDSLG-GRVRVIVT 418 Query: 397 GTAPLNQETAEFF-LSLDIPIGELYGLSESSGPHTISNQNNYRL------LSCGKI-LTG 448 G AP++ FF ++ + E YG +E +G T + ++ L+C + L Sbjct: 419 GAAPMSTSVMTFFRAAMGCQVYEAYGQTECTGGCTFTLPGDWTSGHVGVPLACNYVKLED 478 Query: 449 CKNM-LFQQNKDGIGEICLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLY 507 +M F N +G E+C+ G ++F GYL+ +T EA+D +GWLH+GD+G+ G L Sbjct: 479 VADMNYFTVNNEG--EVCIKGTNVFKGYLKDPEKTQEALDSDGWLHTGDIGRWLPNGTLK 536 Query: 508 VTGHIKEILITAGGENVPPIPVETLVKKKIPIISNAMLVGDKLKFLSMLLTLKCEMNQMS 567 + K I A GE + P +E + + P++ + G+ L+ S++ + + + + Sbjct: 537 IIDRKKNIFKLAQGEYIAPEKIENIYNRSQPVL-QIFVHGESLR-SSLVGVVVPDTDVLP 594 Query: 568 GEPLDKLNFEAINFCRGLGSQASTVTEIVKQQDPLVYKAIQQGINAVNQEA-MNNAQRIE 626 +F LG + S E+ + Q +V +AI + + + +E+ + ++++ Sbjct: 595 ------------SFAAKLGVKGS-FEELCQNQ--VVREAILEDLQKIGKESGLKTFEQVK 639 Query: 627 KWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQIDHMY 665 + + FSI G L P +K KR +++ ++ QID +Y Sbjct: 640 AIFLHPEPFSIENGLLTPTLKAKRGELSKYFRTQIDSLY 678 >gi|42794756 acyl-CoA synthetase long-chain family member 5 isoform a [Homo sapiens] Length = 739 Score = 159 bits (401), Expect = 1e-38 Identities = 159/639 (24%), Positives = 289/639 (45%), Gaps = 61/639 (9%) Query: 52 TIPEFFRESVNRFGTYPALA-SKNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHG--V 108 T+ E F+ + P L K + + L++ Q + L+ G + V Sbjct: 132 TMYEVFQRGLAVSDNGPCLGYRKPNQPYRWLSYKQVSDRAEYLGSCLLHKGYKSSPDQFV 191 Query: 109 GILGFNSAEWFITAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKIL 168 GI N EW I+ + + V +Y T E +++ A + +++ + Q+ ++ Sbjct: 192 GIFAQNRPEWIISELACYTYSMVAVPLYDTLGPEAIVHIVNKADIAMVICDTPQKALVLI 251 Query: 169 SIPQSSLEPLKAIIQYRLPM---------KKNNNLYSWDDFMELGRSIPDTQLEQVIESQ 219 + P +I P K + S D LG+ + E Sbjct: 252 GNVEKGFTPSLKVIILMDPFDDDLKQRGEKSGIEILSLYDAENLGKEHFRKPVPPSPED- 310 Query: 220 KANQCAVLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDK---HETVVSYLPLSHI 276 +V+ +TSGTTG PKG M++H NI A A K + + + +SYLPL+H+ Sbjct: 311 ----LSVICFTSGTTGDPKGAMITHQNIVSNAAAFLKCVEHAYEPTPDDVAISYLPLAHM 366 Query: 277 AAQMMDIWVPIKIGALTYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSA 336 +++ V GA F Q D L +K +KPT+F VP++ +I++ V+ N A Sbjct: 367 FERIVQA-VVYSCGARVGFFQGDIR--LLADDMKTLKPTLFPAVPRLLNRIYDKVQ-NEA 422 Query: 337 KSMGLKKKAFVWARNIGFKVNSKKMLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFIS 396 K+ LKK A + FK K ++ + L+F+K++ SLG ++ Sbjct: 423 KTP-LKKFLLKLAVSSKFKELQKGIIRHDS------FWDKLIFAKIQDSLG-GRVRVIVT 474 Query: 397 GTAPLNQETAEFF-LSLDIPIGELYGLSESSGPHTISNQNNYRL------LSCGKI-LTG 448 G AP++ FF ++ + E YG +E +G T + ++ L+C + L Sbjct: 475 GAAPMSTSVMTFFRAAMGCQVYEAYGQTECTGGCTFTLPGDWTSGHVGVPLACNYVKLED 534 Query: 449 CKNM-LFQQNKDGIGEICLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLY 507 +M F N +G E+C+ G ++F GYL+ +T EA+D +GWLH+GD+G+ G L Sbjct: 535 VADMNYFTVNNEG--EVCIKGTNVFKGYLKDPEKTQEALDSDGWLHTGDIGRWLPNGTLK 592 Query: 508 VTGHIKEILITAGGENVPPIPVETLVKKKIPIISNAMLVGDKLKFLSMLLTLKCEMNQMS 567 + K I A GE + P +E + + P++ + G+ L+ S++ + + + + Sbjct: 593 IIDRKKNIFKLAQGEYIAPEKIENIYNRSQPVL-QIFVHGESLR-SSLVGVVVPDTDVLP 650 Query: 568 GEPLDKLNFEAINFCRGLGSQASTVTEIVKQQDPLVYKAIQQGINAVNQEA-MNNAQRIE 626 +F LG + S E+ + Q +V +AI + + + +E+ + ++++ Sbjct: 651 ------------SFAAKLGVKGS-FEELCQNQ--VVREAILEDLQKIGKESGLKTFEQVK 695 Query: 627 KWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQIDHMY 665 + + FSI G L P +K KR +++ ++ QID +Y Sbjct: 696 AIFLHPEPFSIENGLLTPTLKAKRGELSKYFRTQIDSLY 734 >gi|40807491 acyl-CoA synthetase long-chain family member 1 [Homo sapiens] Length = 698 Score = 155 bits (392), Expect = 1e-37 Identities = 157/641 (24%), Positives = 293/641 (45%), Gaps = 65/641 (10%) Query: 52 TIPEFFRESVNRFGTYPALAS-KNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHG--V 108 T+ E F+ + P L S K + +E L++ Q E +LI+ G + + Sbjct: 91 TLYEGFQRGIQVSNNGPCLGSRKPDQPYEWLSYKQVAELSECIGSALIQKGFKTAPDQFI 150 Query: 109 GILGFNSAEWFITAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKIL 168 GI N EW I G + V +Y T E Y++ A+++++ V+ ++ + +L Sbjct: 151 GIFAQNRPEWVIIEQGCFAYSMVIVPLYDTLGNEAITYIVNKAELSLVFVDKPEKAKLLL 210 Query: 169 SIPQSSLEP-LKAIIQYRLPMKKNNNLYSWDDFMELGR--SIPDTQLEQVIESQKANQ-- 223 ++ L P LK I+ + Y + +E G+ + T ++ + + +AN+ Sbjct: 211 EGVENKLIPGLKIIVVM--------DAYG-SELVERGQRCGVEVTSMKAMEDLGRANRRK 261 Query: 224 --------CAVLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDK---HETVVSYLP 272 AV+ +TSGTTG PKG M++H NI A K + T +T++S+LP Sbjct: 262 PKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAFVKATENTVNPCPDDTLISFLP 321 Query: 273 LSHIAAQMMDIWVPIKIGALTYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVK 332 L+H+ ++++ V + GA F Q D L+ LK ++PTVF VP++ ++ + + Sbjct: 322 LAHMFERVVEC-VMLCHGAKIGFFQGDIR--LLMDDLKVLQPTVFPVVPRLLNRMFDRIF 378 Query: 333 KNSAKSMGLKKKAFVWARNIGFKVNSKKMLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCH 392 + + LK+ W + K ++ + + + L+F KV++SLG Sbjct: 379 GQANTT--LKR----WLLDFASKRKEAEL--RSGIIRNNSLWDRLIFHKVQSSLG-GRVR 429 Query: 393 SFISGTAPLNQETAEFF-LSLDIPIGELYGLSESSGPHTISNQNNYRL------LSCGKI 445 ++G AP++ F +L E YG +E + ++ ++ + C I Sbjct: 430 LMVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLI 489 Query: 446 LTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGF 505 + +G GE+C+ G ++F GYL+ +T EA+D +GWLH+GD+G+ G Sbjct: 490 KLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGT 549 Query: 506 LYVTGHIKEILITAGGENVPPIPVETLVKKKIPIISNAMLVGDKLKFLSMLLTLKCEMNQ 565 L + K I A GE + P +E + + P ++ + G+ L+ + L+ + + Sbjct: 550 LKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEP-VAQVFVHGESLQ--AFLIAIVVPDVE 606 Query: 566 MSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQDPLVYKAIQQGINAVNQEA-MNNAQR 624 K FE + E+ + +D V KAI + + + +++ + ++ Sbjct: 607 TLCSWAQKRGFE------------GSFEELCRNKD--VKKAILEDMVRLGKDSGLKPFEQ 652 Query: 625 IEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQIDHMY 665 ++ + + FSI G L P MK KR + ++ QID +Y Sbjct: 653 VKGITLHPELFSIDNGLLTPTMKAKRPELRNYFRSQIDDLY 693 >gi|4758332 acyl-CoA synthetase long-chain family member 4 isoform 1 [Homo sapiens] Length = 670 Score = 149 bits (377), Expect = 6e-36 Identities = 168/669 (25%), Positives = 289/669 (43%), Gaps = 93/669 (13%) Query: 52 TIPEFFRESVNRFGTYPALASK-----------NGKKWEIL-----NFNQYYEACRKA-- 93 T+ + F +V++FG +L ++ NGK ++ L + Y E R+ Sbjct: 37 TLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNYLEVNRRVNN 96 Query: 94 -AKSLIKLGLERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNSAEVCQYVITHAK 152 L LGL+ + + I AEW I A V +YAT E + + ++ Sbjct: 97 FGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESE 156 Query: 153 VNILLVENDQQLQKILSIPQSSLEPLKAIIQY------RLPMKKNNNLYSWDDFMELGRS 206 + L+ + + L+ L + +K II + + ++S ELG + Sbjct: 157 ASYLIT-SVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPEGFEIHSMQSVEELGSN 215 Query: 207 IPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKL--TDKH 264 + + + A+++YTSG+TG PKGVM+ H N+ IAG + ++ Sbjct: 216 PENLGIPP--SRPTPSDMAIVMYTSGSTGRPKGVMMHHSNL--IAGMTGQCERIPGLGPK 271 Query: 265 ETVVSYLPLSHI---AAQMMDIWVPIKIG---ALTYFAQADALKGTLVSTLKEVKPTVFI 318 +T + YLPL+H+ A++ +IG LT Q+ +K +KPT+ Sbjct: 272 DTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMA 331 Query: 319 GVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKKMLGKYNTPVSYRMAKTLV 378 VP+I ++I++ V + ++K F IG+ +++ Y+ P + L+ Sbjct: 332 AVPEIMDRIYKNVMSKVQEMNYIQKTLF----KIGYDYKLEQIKKGYDAP----LCNLLL 383 Query: 379 FSKVKTSLGLDHCHSFISGTAPLNQETAEFF-LSLDIPIGELYGLSESSGPHTISNQNNY 437 F KVK LG + +SG APL+ +T F + PIG+ YGL+ES G T++ +Y Sbjct: 384 FKKVKALLG-GNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDY 442 Query: 438 RLLSCGKILTGCKNMLFQQNKDGI---------GEICLWGRHIFMGYLESETETTE--AI 486 G L C+ L + G GEI + G++I MGY ++E +T E ++ Sbjct: 443 TTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSV 502 Query: 487 DDEG--WLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPIISN-- 542 D+ G W +GD+G+ G L + K+++ GE V VE + K P+I N Sbjct: 503 DENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAAL-KNCPLIDNIC 561 Query: 543 AMLVGDKLKFLSML------LTLKCEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIV 596 A D+ +S + LTL + + G +D N A+ EI+ Sbjct: 562 AFAKSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAME------------AEIL 609 Query: 597 KQQDPLVYKAIQQGINAVNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQK 656 K+ I++ NA+ E ++ + + ++ G + KLKR + Sbjct: 610 KE--------IREAANAMKLERFEIPIKVR---LSPEPWTPETGLVTDAFKLKRKELRNH 658 Query: 657 YKKQIDHMY 665 Y K I+ MY Sbjct: 659 YLKDIERMY 667 >gi|12669909 acyl-CoA synthetase long-chain family member 4 isoform 2 [Homo sapiens] Length = 711 Score = 149 bits (377), Expect = 6e-36 Identities = 168/669 (25%), Positives = 289/669 (43%), Gaps = 93/669 (13%) Query: 52 TIPEFFRESVNRFGTYPALASK-----------NGKKWEIL-----NFNQYYEACRKA-- 93 T+ + F +V++FG +L ++ NGK ++ L + Y E R+ Sbjct: 78 TLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNYLEVNRRVNN 137 Query: 94 -AKSLIKLGLERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNSAEVCQYVITHAK 152 L LGL+ + + I AEW I A V +YAT E + + ++ Sbjct: 138 FGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESE 197 Query: 153 VNILLVENDQQLQKILSIPQSSLEPLKAIIQY------RLPMKKNNNLYSWDDFMELGRS 206 + L+ + + L+ L + +K II + + ++S ELG + Sbjct: 198 ASYLIT-SVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPEGFEIHSMQSVEELGSN 256 Query: 207 IPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKL--TDKH 264 + + + A+++YTSG+TG PKGVM+ H N+ IAG + ++ Sbjct: 257 PENLGIPP--SRPTPSDMAIVMYTSGSTGRPKGVMMHHSNL--IAGMTGQCERIPGLGPK 312 Query: 265 ETVVSYLPLSHI---AAQMMDIWVPIKIG---ALTYFAQADALKGTLVSTLKEVKPTVFI 318 +T + YLPL+H+ A++ +IG LT Q+ +K +KPT+ Sbjct: 313 DTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMA 372 Query: 319 GVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKKMLGKYNTPVSYRMAKTLV 378 VP+I ++I++ V + ++K F IG+ +++ Y+ P + L+ Sbjct: 373 AVPEIMDRIYKNVMSKVQEMNYIQKTLF----KIGYDYKLEQIKKGYDAP----LCNLLL 424 Query: 379 FSKVKTSLGLDHCHSFISGTAPLNQETAEFF-LSLDIPIGELYGLSESSGPHTISNQNNY 437 F KVK LG + +SG APL+ +T F + PIG+ YGL+ES G T++ +Y Sbjct: 425 FKKVKALLG-GNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDY 483 Query: 438 RLLSCGKILTGCKNMLFQQNKDGI---------GEICLWGRHIFMGYLESETETTE--AI 486 G L C+ L + G GEI + G++I MGY ++E +T E ++ Sbjct: 484 TTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSV 543 Query: 487 DDEG--WLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPIISN-- 542 D+ G W +GD+G+ G L + K+++ GE V VE + K P+I N Sbjct: 544 DENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAAL-KNCPLIDNIC 602 Query: 543 AMLVGDKLKFLSML------LTLKCEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIV 596 A D+ +S + LTL + + G +D N A+ EI+ Sbjct: 603 AFAKSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAME------------AEIL 650 Query: 597 KQQDPLVYKAIQQGINAVNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQK 656 K+ I++ NA+ E ++ + + ++ G + KLKR + Sbjct: 651 KE--------IREAANAMKLERFEIPIKVR---LSPEPWTPETGLVTDAFKLKRKELRNH 699 Query: 657 YKKQIDHMY 665 Y K I+ MY Sbjct: 700 YLKDIERMY 708 >gi|57165412 acyl-CoA synthetase long-chain family member 6 isoform b [Homo sapiens] Length = 722 Score = 141 bits (356), Expect = 2e-33 Identities = 154/643 (23%), Positives = 292/643 (45%), Gaps = 59/643 (9%) Query: 47 HETPMTIPEFFRESVNRFGTYPALASKNGKK-WEILNFNQYYEACRKAAKSLI----KLG 101 ++ T+ + FR ++ G P L + K+ ++ L++ + + L+ K Sbjct: 111 YDDARTMYQVFRRGLSISGNGPCLGFRKPKQPYQWLSYQEVADRAEFLGSGLLQHNCKAC 170 Query: 102 LERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVEND 161 ++F +G+ N EW I + + V +Y T +Y+I A ++ ++V+ Sbjct: 171 TDQF--IGVFAQNRPEWIIVELACYTYSMVVVPLYDTLGPGAIRYIINTADISTVIVDKP 228 Query: 162 QQLQKILSIPQSSLEP-LKAII---QYRLPMKKNNNLYSWDDFMELGRSIPDTQLE--QV 215 Q+ +L + P LK II + +K+ ++ +++ D E Q Sbjct: 229 QKAVLLLEHVERKETPGLKLIILMDPFEEALKERGQ--KCGVVIKSMQAVEDCGQENHQA 286 Query: 216 IESQKANQCAVLIYTSGTTGIPKGVMLSHDNITWIAGA---VTKDFKLTDKHETVVSYLP 272 + + +++ +TSGTTG PKG ML+H N+ VT+ + + ++S+LP Sbjct: 287 PVPPQPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGFLKVTEKVIFPRQDDVLISFLP 346 Query: 273 LSHIAAQMMDIWVPIKIGALTYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVK 332 L+H+ +++ V G + +F Q D L +K + PT+F VP++ ++++ + Sbjct: 347 LAHMFERVIQSVVYCHGGRVGFF-QGDIR--LLSDDMKALCPTIFPVVPRLLNRMYDKIF 403 Query: 333 KNSAKSMGLKKKAFVWARNIGFKVNSKKMLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCH 392 S + LK+ W + F K+ + + + L F+K++ SLG Sbjct: 404 --SQANTPLKR----WL--LEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLG-GCVR 454 Query: 393 SFISGTAPLNQETAEFF-LSLDIPIGELYGLSESSGPHTISNQNNYRL------LSCGKI 445 ++G AP + F +L + E YG +E + T + ++ L C I Sbjct: 455 MIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHI 514 Query: 446 -LTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDGLG 504 L + + + K G GEIC+ G ++F GYL+ T EA+D +GWLH+GD+G+ G Sbjct: 515 KLVDVEELNYWACK-GEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAG 573 Query: 505 FLYVTGHIKEILITAGGENVPPIPVETLVKKKIPIISNAMLVGDKLK-FLSMLLTLKCEM 563 L + K I A GE V P +E + + P ++ + GD LK FL ++ E+ Sbjct: 574 TLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQP-VAQIYVHGDSLKAFLVGIVVPDPEV 632 Query: 564 NQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQDPLVYKAIQQGINAVNQEA-MNNA 622 + RG+ T ++ +D + KAI + + + +E+ +++ Sbjct: 633 MPSWAQK------------RGI---EGTYADLCTNKD--LKKAILEDMVRLGKESGLHSF 675 Query: 623 QRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQIDHMY 665 ++++ I FS+ G L P +K KR + + +KKQI+ +Y Sbjct: 676 EQVKAIHIHSDMFSVQNGLLTPTLKAKRPELREYFKKQIEELY 718 >gi|57165410 acyl-CoA synthetase long-chain family member 6 isoform a [Homo sapiens] Length = 722 Score = 141 bits (355), Expect = 2e-33 Identities = 156/646 (24%), Positives = 292/646 (45%), Gaps = 65/646 (10%) Query: 47 HETPMTIPEFFRESVNRFGTYPALASKNGKK-WEILNFNQYYEACRKAAKSLI----KLG 101 ++ T+ + FR ++ G P L + K+ ++ L++ + + L+ K Sbjct: 111 YDDARTMYQVFRRGLSISGNGPCLGFRKPKQPYQWLSYQEVADRAEFLGSGLLQHNCKAC 170 Query: 102 LERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVEND 161 ++F +G+ N EW I + + V +Y T +Y+I A ++ ++V+ Sbjct: 171 TDQF--IGVFAQNRPEWIIVELACYTYSMVVVPLYDTLGPGAIRYIINTADISTVIVDKP 228 Query: 162 QQLQKILSIPQSSLEP-LKAII---QYRLPMKKNNNLYSWDDFMELGRSIPDTQLE--QV 215 Q+ +L + P LK II + +K+ ++ +++ D E Q Sbjct: 229 QKAVLLLEHVERKETPGLKLIILMDPFEEALKERGQ--KCGVVIKSMQAVEDCGQENHQA 286 Query: 216 IESQKANQCAVLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDKH------ETVVS 269 + + +++ +TSGTTG PKG ML+H N+ + K+T+ + +S Sbjct: 287 PVPPQPDDLSIVCFTSGTTGNPKGAMLTHGNVV---ADFSGFLKVTESQWAPTCADVHIS 343 Query: 270 YLPLSHIAAQMMDIWVPIKIGALTYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEKIHE 329 YLPL+H+ +M+ V G + +F Q D L +K + PT+F VP++ ++++ Sbjct: 344 YLPLAHMFERMVQSVVYCHGGRVGFF-QGDIR--LLSDDMKALCPTIFPVVPRLLNRMYD 400 Query: 330 MVKKNSAKSMGLKKKAFVWARNIGFKVNSKKMLGKYNTPVSYRMAKTLVFSKVKTSLGLD 389 + S + LK+ W + F K+ + + + L F+K++ SLG Sbjct: 401 KIF--SQANTPLKR----WL--LEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLG-G 451 Query: 390 HCHSFISGTAPLNQETAEFF-LSLDIPIGELYGLSESSGPHTISNQNNYRL------LSC 442 ++G AP + F +L + E YG +E + T + ++ L C Sbjct: 452 CVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPC 511 Query: 443 GKI-LTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLD 501 I L + + + K G GEIC+ G ++F GYL+ T EA+D +GWLH+GD+G+ Sbjct: 512 NHIKLVDVEELNYWACK-GEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWL 570 Query: 502 GLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPIISNAMLVGDKLK-FLSMLLTLK 560 G L + K I A GE V P +E + + P ++ + GD LK FL ++ Sbjct: 571 PAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQP-VAQIYVHGDSLKAFLVGIVVPD 629 Query: 561 CEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQDPLVYKAIQQGINAVNQEA-M 619 E+ + RG+ T ++ +D + KAI + + + +E+ + Sbjct: 630 PEVMPSWAQK------------RGI---EGTYADLCTNKD--LKKAILEDMVRLGKESGL 672 Query: 620 NNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQIDHMY 665 ++ ++++ I FS+ G L P +K KR + + +KKQI+ +Y Sbjct: 673 HSFEQVKAIHIHSDMFSVQNGLLTPTLKAKRPELREYFKKQIEELY 718 >gi|42794754 acyl-CoA synthetase long-chain family member 3 [Homo sapiens] Length = 720 Score = 137 bits (344), Expect = 4e-32 Identities = 128/494 (25%), Positives = 224/494 (45%), Gaps = 51/494 (10%) Query: 81 LNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNS 140 L++ + L LG + + I AEW I A + V +YAT Sbjct: 135 LSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLG 194 Query: 141 AEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKAIIQYRLPMKKNNNLYSWDDF 200 + + +V ++ + K+ I SL P + R + + +W +F Sbjct: 195 GPAIVHALNETEVTNIITSKELLQTKLKDIV--SLVP-----RLRHIITVDGKPPTWSEF 247 Query: 201 -----MELGRSIPDTQLEQVIESQKANQ-----CAVLIYTSGTTGIPKGVMLSHDNITWI 250 + ++ + +E+Q ++ AV++YTSG+TG+PKGVM+SH NI I Sbjct: 248 PKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNI--I 305 Query: 251 AGAVTKDFKLTD--KHETVVSYLPLSHI---AAQMMDIWVPIKIG---ALTYFAQADALK 302 AG ++ + + + + YLPL+H+ +A+++ + +IG T Q+ +K Sbjct: 306 AGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIK 365 Query: 303 GTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKKML 362 +KPT+ VP+I ++I++ V ++ ++ F+ A N + SK Sbjct: 366 KGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGR- 424 Query: 363 GKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFF-LSLDIPIGELYG 421 NTP + + VF KV++ LG + + G APL+ T F + P+G+ YG Sbjct: 425 ---NTP----LCDSFVFRKVRSLLG-GNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYG 476 Query: 422 LSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGI---------GEICLWGRHIF 472 L+ES+G TIS +Y G L C+ L + G GEI + G+ + Sbjct: 477 LTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVT 536 Query: 473 MGYLESETET-TEAIDDEG---WLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIP 528 MGY ++E +T + +DE WL +GD+G+ + G L + K+++ GE V Sbjct: 537 MGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGK 596 Query: 529 VETLVKKKIPIISN 542 VE + K +P++ N Sbjct: 597 VEAAL-KNLPLVDN 609 >gi|42794752 acyl-CoA synthetase long-chain family member 3 [Homo sapiens] Length = 720 Score = 137 bits (344), Expect = 4e-32 Identities = 128/494 (25%), Positives = 224/494 (45%), Gaps = 51/494 (10%) Query: 81 LNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNS 140 L++ + L LG + + I AEW I A + V +YAT Sbjct: 135 LSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLG 194 Query: 141 AEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKAIIQYRLPMKKNNNLYSWDDF 200 + + +V ++ + K+ I SL P + R + + +W +F Sbjct: 195 GPAIVHALNETEVTNIITSKELLQTKLKDIV--SLVP-----RLRHIITVDGKPPTWSEF 247 Query: 201 -----MELGRSIPDTQLEQVIESQKANQ-----CAVLIYTSGTTGIPKGVMLSHDNITWI 250 + ++ + +E+Q ++ AV++YTSG+TG+PKGVM+SH NI I Sbjct: 248 PKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNI--I 305 Query: 251 AGAVTKDFKLTD--KHETVVSYLPLSHI---AAQMMDIWVPIKIG---ALTYFAQADALK 302 AG ++ + + + + YLPL+H+ +A+++ + +IG T Q+ +K Sbjct: 306 AGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIK 365 Query: 303 GTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKKML 362 +KPT+ VP+I ++I++ V ++ ++ F+ A N + SK Sbjct: 366 KGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGR- 424 Query: 363 GKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFF-LSLDIPIGELYG 421 NTP + + VF KV++ LG + + G APL+ T F + P+G+ YG Sbjct: 425 ---NTP----LCDSFVFRKVRSLLG-GNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYG 476 Query: 422 LSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGI---------GEICLWGRHIF 472 L+ES+G TIS +Y G L C+ L + G GEI + G+ + Sbjct: 477 LTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVT 536 Query: 473 MGYLESETET-TEAIDDEG---WLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIP 528 MGY ++E +T + +DE WL +GD+G+ + G L + K+++ GE V Sbjct: 537 MGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGK 596 Query: 529 VETLVKKKIPIISN 542 VE + K +P++ N Sbjct: 597 VEAAL-KNLPLVDN 609 >gi|156151445 acyl-CoA synthetase family member 2 [Homo sapiens] Length = 615 Score = 82.0 bits (201), Expect = 2e-15 Identities = 114/505 (22%), Positives = 187/505 (37%), Gaps = 96/505 (19%) Query: 81 LNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNS 140 L F Q E KAA L+ +GL + +G+ G NS W + + AG + V + Sbjct: 100 LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQ 159 Query: 141 AEVCQYVITHAKVNILLVEND---QQLQKIL-------------SIPQSSLEPLKAIIQY 184 A +YV+ L+ QQ +L ++ L L +I Sbjct: 160 AMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEVENAQPGALKSQRLPDLTTVISV 219 Query: 185 RLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLI---YTSGTTGIPKGVM 241 P+ L D+ + G + L+Q+ +Q+ C I +TSGTTG PKG Sbjct: 220 DAPLPGTLLL---DEVVAAGST--RQHLDQLQYNQQFLSCHDPINIQFTSGTTGSPKGAT 274 Query: 242 LSHDNITWIAGAVTKDFKLTDKHETVVSYL---PLSHIAAQMMDIWVPIKIGALTYFAQA 298 LSH NI + + + KL +K + + PL H + + + GA A Sbjct: 275 LSHYNIVNNSNILGERLKLHEKTPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLILASP 334 Query: 299 DALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWA-------RN 351 + + + T G P ++ I +S + + R Sbjct: 335 IFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRA 394 Query: 352 IGFKVNSKKMLGKY----NTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAE 407 I K+N K ++ Y N+PV++ A ++T E Sbjct: 395 IINKINMKDLVVAYGTTENSPVTF---------------------------AHFPEDTVE 427 Query: 408 FFLSLDIPIGELYGLSESSG---PHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGIGEI 464 +ES G PHT + N + K+ T GE+ Sbjct: 428 -------------QKAESVGRIMPHTEARIMNMEAGTLAKLNTP-------------GEL 461 Query: 465 CLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENV 524 C+ G + +GY +T EA+D + W +GD+ ++ GF + G K+++I GGEN+ Sbjct: 462 CIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMII-RGGENI 520 Query: 525 PPIPVETLVKKKIPIISNAMLVGDK 549 P +E P + +VG K Sbjct: 521 YPAELEDFFHTH-PKVQEVQVVGVK 544 >gi|187761345 acyl-CoA synthetase family member 3 [Homo sapiens] Length = 576 Score = 74.7 bits (182), Expect = 3e-13 Identities = 109/484 (22%), Positives = 191/484 (39%), Gaps = 63/484 (13%) Query: 64 FGTYPALASKNGKKWEILNFNQYYEACRKAAKSLIKL-----GLERFHGVGILGFNSAEW 118 FG AL ++G+ + + Y + ++ + +L G R V L N A + Sbjct: 53 FGDRIALVDQHGRH----TYRELYSRSLRLSQEICRLCGCVGGDLREERVSFLCANDASY 108 Query: 119 FITAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVEND--QQLQKILSIPQSSLE 176 + + ++GG+ V +Y + A +YVI ++ +++L + + L ++ L Sbjct: 109 VVAQWASWMSGGVAVPLYRKHPAAQLEYVICDSQSSVVLASQEYLELLSPVVRKLGVPLL 168 Query: 177 PLKAIIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGI 236 PL I + +E +P V E N+ A++IYTSGTTG Sbjct: 169 PLTPAI--------------YTGAVEEPAEVP------VPEQGWRNKGAMIIYTSGTTGR 208 Query: 237 PKGVMLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGA----L 292 PKGV+ +H NI + + + T K + ++ LPL H+ + + P+ +GA + Sbjct: 209 PKGVLSTHQNIRAVVTGLVHKWAWT-KDDVILHVLPLHHVHGVVNALLCPLWVGATCVMM 267 Query: 293 TYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNI 352 F+ + L S + VF+ VP I+ K+ E ++ + V I Sbjct: 268 PEFSPQQVWEKFLSSETPRI--NVFMAVPTIYTKLMEYYDRHFTQPHAQDFLRAVCEEKI 325 Query: 353 GFKVNSKKMLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSL 412 V+ L PV + K + + G+ +SG PL S+ Sbjct: 326 RLMVSGSAAL---PLPVLEKW-KNITGHTLLERYGMTEIGMALSG--PLT-TAVRLPGSV 378 Query: 413 DIPIGELYGLSESSGP------HTISNQNNYRLLSCGKILTGCKNMLFQQNKDGIGEICL 466 P+ + S P +TI + + R K+ G F++ + GE+ + Sbjct: 379 GTPLPGVQVRIVSENPQREACSYTIHAEGDER---GTKVTPG-----FEEKE---GELLV 427 Query: 467 WGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPP 526 G +F Y ET A +GW +GD G ++ G +I GG V Sbjct: 428 RGPSVFREYWNKPEETKSAFTLDGWFKTGDTVVFKD-GQYWIRGRTSVDIIKTGGYKVSA 486 Query: 527 IPVE 530 + VE Sbjct: 487 LEVE 490 >gi|187761343 acyl-CoA synthetase family member 3 [Homo sapiens] Length = 576 Score = 74.7 bits (182), Expect = 3e-13 Identities = 109/484 (22%), Positives = 191/484 (39%), Gaps = 63/484 (13%) Query: 64 FGTYPALASKNGKKWEILNFNQYYEACRKAAKSLIKL-----GLERFHGVGILGFNSAEW 118 FG AL ++G+ + + Y + ++ + +L G R V L N A + Sbjct: 53 FGDRIALVDQHGRH----TYRELYSRSLRLSQEICRLCGCVGGDLREERVSFLCANDASY 108 Query: 119 FITAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVEND--QQLQKILSIPQSSLE 176 + + ++GG+ V +Y + A +YVI ++ +++L + + L ++ L Sbjct: 109 VVAQWASWMSGGVAVPLYRKHPAAQLEYVICDSQSSVVLASQEYLELLSPVVRKLGVPLL 168 Query: 177 PLKAIIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGI 236 PL I + +E +P V E N+ A++IYTSGTTG Sbjct: 169 PLTPAI--------------YTGAVEEPAEVP------VPEQGWRNKGAMIIYTSGTTGR 208 Query: 237 PKGVMLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGA----L 292 PKGV+ +H NI + + + T K + ++ LPL H+ + + P+ +GA + Sbjct: 209 PKGVLSTHQNIRAVVTGLVHKWAWT-KDDVILHVLPLHHVHGVVNALLCPLWVGATCVMM 267 Query: 293 TYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNI 352 F+ + L S + VF+ VP I+ K+ E ++ + V I Sbjct: 268 PEFSPQQVWEKFLSSETPRI--NVFMAVPTIYTKLMEYYDRHFTQPHAQDFLRAVCEEKI 325 Query: 353 GFKVNSKKMLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSL 412 V+ L PV + K + + G+ +SG PL S+ Sbjct: 326 RLMVSGSAAL---PLPVLEKW-KNITGHTLLERYGMTEIGMALSG--PLT-TAVRLPGSV 378 Query: 413 DIPIGELYGLSESSGP------HTISNQNNYRLLSCGKILTGCKNMLFQQNKDGIGEICL 466 P+ + S P +TI + + R K+ G F++ + GE+ + Sbjct: 379 GTPLPGVQVRIVSENPQREACSYTIHAEGDER---GTKVTPG-----FEEKE---GELLV 427 Query: 467 WGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPP 526 G +F Y ET A +GW +GD G ++ G +I GG V Sbjct: 428 RGPSVFREYWNKPEETKSAFTLDGWFKTGDTVVFKD-GQYWIRGRTSVDIIKTGGYKVSA 486 Query: 527 IPVE 530 + VE Sbjct: 487 LEVE 490 >gi|157311624 acyl-CoA synthetase medium-chain family member 2B [Homo sapiens] Length = 577 Score = 52.8 bits (125), Expect = 1e-06 Identities = 110/495 (22%), Positives = 198/495 (40%), Gaps = 84/495 (16%) Query: 68 PALASKNGKKWEIL-NFNQYYEACRKAAKSLI-KLGLERFHGVGILGFNSAEWFITAVGA 125 PAL NGK E++ NF + E ++AA L GL+R V ++ EW++ +G Sbjct: 67 PALWWVNGKGKELMWNFRELSENSQQAANILSGACGLQRGDRVAVMLPRVPEWWLVILGC 126 Query: 126 ILAGGLCV-GIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKAIIQY 184 I AG + + G S ++ Y + +K + V D+ +Q++ ++ S L+ + Sbjct: 127 IRAGLIFMPGTIQMKSTDIL-YRLQMSKAKAI-VAGDEVIQEVDTVA-SECPSLRIKL-- 181 Query: 185 RLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGVMLSH 244 + + W +F +L T SQ+A+ + +TSGT+G+PK S+ Sbjct: 182 ---LVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEAS---AIYFTSGTSGLPKMAEHSY 235 Query: 245 DNITWIA--GAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADALK 302 ++ A A + +D T+ + +I +++ W +GA T+ Sbjct: 236 SSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILGSLLESWT---LGACTF-------- 284 Query: 303 GTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKKML 362 V L + P V ++K S+ + K M+ Sbjct: 285 ---VHLLPKFDPLV-------------ILKTLSSYPI-------------------KSMM 309 Query: 363 GKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAE-FFLSLDIPIGELYG 421 G P+ YRM + + +S H + ++G L ET E + + I E YG Sbjct: 310 G---APIVYRM----LLQQDLSSYKFPHLQNCLAGGESLLPETLENWRAQTGLDIREFYG 362 Query: 422 LSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGI------GEICLWGR-----H 470 +E+ +S + G C ++ +K + G+I + + Sbjct: 363 QTETGLTCMVSKTMKIKPGYMG-TAASCYDVQVIDDKGNVLPPGTEGDIGIRVKPIRPIG 421 Query: 471 IFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVE 530 IF GY+E+ +T I + WL GD G D G+ G +I I + G + P VE Sbjct: 422 IFSGYVENPDKTAANIRGDFWL-LGDRGIKDEDGYFQFMGRADDI-INSSGYRIGPSEVE 479 Query: 531 TLVKKKIPIISNAML 545 + K ++ A++ Sbjct: 480 NALMKHPAVVETAVI 494 >gi|157311622 acyl-CoA synthetase medium-chain family member 2B [Homo sapiens] Length = 577 Score = 52.8 bits (125), Expect = 1e-06 Identities = 110/495 (22%), Positives = 198/495 (40%), Gaps = 84/495 (16%) Query: 68 PALASKNGKKWEIL-NFNQYYEACRKAAKSLI-KLGLERFHGVGILGFNSAEWFITAVGA 125 PAL NGK E++ NF + E ++AA L GL+R V ++ EW++ +G Sbjct: 67 PALWWVNGKGKELMWNFRELSENSQQAANILSGACGLQRGDRVAVMLPRVPEWWLVILGC 126 Query: 126 ILAGGLCV-GIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKAIIQY 184 I AG + + G S ++ Y + +K + V D+ +Q++ ++ S L+ + Sbjct: 127 IRAGLIFMPGTIQMKSTDIL-YRLQMSKAKAI-VAGDEVIQEVDTVA-SECPSLRIKL-- 181 Query: 185 RLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGVMLSH 244 + + W +F +L T SQ+A+ + +TSGT+G+PK S+ Sbjct: 182 ---LVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEAS---AIYFTSGTSGLPKMAEHSY 235 Query: 245 DNITWIA--GAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADALK 302 ++ A A + +D T+ + +I +++ W +GA T+ Sbjct: 236 SSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILGSLLESWT---LGACTF-------- 284 Query: 303 GTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKKML 362 V L + P V ++K S+ + K M+ Sbjct: 285 ---VHLLPKFDPLV-------------ILKTLSSYPI-------------------KSMM 309 Query: 363 GKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAE-FFLSLDIPIGELYG 421 G P+ YRM + + +S H + ++G L ET E + + I E YG Sbjct: 310 G---APIVYRM----LLQQDLSSYKFPHLQNCLAGGESLLPETLENWRAQTGLDIREFYG 362 Query: 422 LSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGI------GEICLWGR-----H 470 +E+ +S + G C ++ +K + G+I + + Sbjct: 363 QTETGLTCMVSKTMKIKPGYMG-TAASCYDVQVIDDKGNVLPPGTEGDIGIRVKPIRPIG 421 Query: 471 IFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVE 530 IF GY+E+ +T I + WL GD G D G+ G +I I + G + P VE Sbjct: 422 IFSGYVENPDKTAANIRGDFWL-LGDRGIKDEDGYFQFMGRADDI-INSSGYRIGPSEVE 479 Query: 531 TLVKKKIPIISNAML 545 + K ++ A++ Sbjct: 480 NALMKHPAVVETAVI 494 >gi|239756507 PREDICTED: similar to Acyl-coenzyme A synthetase ACSM2B, mitochondrial isoform 2 [Homo sapiens] Length = 571 Score = 50.1 bits (118), Expect = 7e-06 Identities = 106/488 (21%), Positives = 192/488 (39%), Gaps = 76/488 (15%) Query: 68 PALASKNGKKWEIL-NFNQYYEACRKAAKSLI-KLGLERFHGVGILGFNSAEWFITAVGA 125 PAL NGK E++ NF + E ++AA L GL+R V ++ EW++ +G Sbjct: 67 PALWWVNGKGKELMWNFRELSENSQQAANVLSGACGLQRGDRVAVMLPRVPEWWLVILGC 126 Query: 126 ILAGGLCV-GIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKAIIQY 184 I AG + + G S ++ Y + +K + V D+ +Q++ ++ S L+ + Sbjct: 127 IRAGLIFMPGTIQMKSTDIL-YRLQMSKAKAI-VAGDEVIQEVDTVA-SECPSLRIKL-- 181 Query: 185 RLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGVMLSH 244 + + W +F +L T SQ+A+ + +TSGT+G+PK S+ Sbjct: 182 ---LVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEAS---AIYFTSGTSGLPKMAEHSY 235 Query: 245 DNITWIA--GAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADALK 302 ++ A A + +D T+ + +I +++ W +GA T+ Sbjct: 236 SSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILGSLLESWT---LGACTF-------- 284 Query: 303 GTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKKML 362 V L + P V ++K S+ + K M+ Sbjct: 285 ---VHLLPKFDPLV-------------ILKTLSSYPI-------------------KSMM 309 Query: 363 GKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAE-FFLSLDIPIGELYG 421 G P+ YRM + + +S H + ++G L ET E + + I E YG Sbjct: 310 G---APIVYRM----LLQQDLSSYKFPHLQNCLAGGESLLPETLENWRAQTGLDIREFYG 362 Query: 422 LSESSGPHTISNQNNYR--LLSCGKILTGCKNMLFQQNKDGIGEICLWGRHI--FMGYLE 477 +E+ +S + + + + F G++ G F G+ E Sbjct: 363 QTETGLTCMVSKTMKIKPGYMGTAASCYDVQVIAFVHGSPRAGDLGFAGTMTLSFCGHQE 422 Query: 478 SETETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKI 537 + +T I + WL GD G D G+ G +I I + G + P VE + K Sbjct: 423 NPDKTAANIRGDFWL-LGDRGIKDEDGYFQFMGRADDI-INSSGYRIGPSEVENALMKHP 480 Query: 538 PIISNAML 545 ++ A++ Sbjct: 481 AVVETAVI 488 >gi|239756505 PREDICTED: similar to Acyl-coenzyme A synthetase ACSM2B, mitochondrial isoform 1 [Homo sapiens] Length = 571 Score = 50.1 bits (118), Expect = 7e-06 Identities = 106/488 (21%), Positives = 192/488 (39%), Gaps = 76/488 (15%) Query: 68 PALASKNGKKWEIL-NFNQYYEACRKAAKSLI-KLGLERFHGVGILGFNSAEWFITAVGA 125 PAL NGK E++ NF + E ++AA L GL+R V ++ EW++ +G Sbjct: 67 PALWWVNGKGKELMWNFRELSENSQQAANVLSGACGLQRGDRVAVMLPRVPEWWLVILGC 126 Query: 126 ILAGGLCV-GIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKAIIQY 184 I AG + + G S ++ Y + +K + V D+ +Q++ ++ S L+ + Sbjct: 127 IRAGLIFMPGTIQMKSTDIL-YRLQMSKAKAI-VAGDEVIQEVDTVA-SECPSLRIKL-- 181 Query: 185 RLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGVMLSH 244 + + W +F +L T SQ+A+ + +TSGT+G+PK S+ Sbjct: 182 ---LVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEAS---AIYFTSGTSGLPKMAEHSY 235 Query: 245 DNITWIA--GAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADALK 302 ++ A A + +D T+ + +I +++ W +GA T+ Sbjct: 236 SSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILGSLLESWT---LGACTF-------- 284 Query: 303 GTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKKML 362 V L + P V ++K S+ + K M+ Sbjct: 285 ---VHLLPKFDPLV-------------ILKTLSSYPI-------------------KSMM 309 Query: 363 GKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAE-FFLSLDIPIGELYG 421 G P+ YRM + + +S H + ++G L ET E + + I E YG Sbjct: 310 G---APIVYRM----LLQQDLSSYKFPHLQNCLAGGESLLPETLENWRAQTGLDIREFYG 362 Query: 422 LSESSGPHTISNQNNYR--LLSCGKILTGCKNMLFQQNKDGIGEICLWGRHI--FMGYLE 477 +E+ +S + + + + F G++ G F G+ E Sbjct: 363 QTETGLTCMVSKTMKIKPGYMGTAASCYDVQVIAFVHGSPRAGDLGFAGTMTLSFCGHQE 422 Query: 478 SETETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKI 537 + +T I + WL GD G D G+ G +I I + G + P VE + K Sbjct: 423 NPDKTAANIRGDFWL-LGDRGIKDEDGYFQFMGRADDI-INSSGYRIGPSEVENALMKHP 480 Query: 538 PIISNAML 545 ++ A++ Sbjct: 481 AVVETAVI 488 >gi|58082049 acyl-CoA synthetase medium-chain family member 2A [Homo sapiens] Length = 577 Score = 47.0 bits (110), Expect = 6e-05 Identities = 108/495 (21%), Positives = 197/495 (39%), Gaps = 84/495 (16%) Query: 68 PALASKNGKKWEIL-NFNQYYEACRKAAKSLI-KLGLERFHGVGILGFNSAEWFITAVGA 125 PAL NGK E++ NF + E ++AA L GL+R V ++ EW++ +G Sbjct: 67 PALWWVNGKGKELMWNFRELSENSQQAANVLSGACGLQRGDRVAVVLPRVPEWWLVILGC 126 Query: 126 ILAGGLCV-GIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKAIIQY 184 I AG + + G S ++ Y + +K + V D+ +Q++ ++ S L+ + Sbjct: 127 IRAGLIFMPGTIQMKSTDIL-YRLQMSKAKAI-VAGDEVIQEVDTVA-SECPSLRIKL-- 181 Query: 185 RLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGVMLSH 244 + + W +F +L T SQ+A+ + +TSGT+G+PK S+ Sbjct: 182 ---LVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEAS---AIYFTSGTSGLPKMAEHSY 235 Query: 245 DNITWIA--GAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADALK 302 ++ A A + +D T+ + +I +M+ W +GA T+ Sbjct: 236 SSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILCSLMEPWA---LGACTF-------- 284 Query: 303 GTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKKML 362 V L + P V ++K S+ + K M+ Sbjct: 285 ---VHLLPKFDPLV-------------ILKTLSSYPI-------------------KSMM 309 Query: 363 GKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAE-FFLSLDIPIGELYG 421 G P+ YRM + + +S H + ++ L ET E + + I E YG Sbjct: 310 G---APIVYRM----LLQQDLSSYKFPHLQNCVTVGESLLPETLENWRAQTGLDIRESYG 362 Query: 422 LSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGI------GEICLWGR-----H 470 +E+ +S + G C ++ +K + G+I + + Sbjct: 363 QTETGLTCMVSKTMKIKPGYMG-TAASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPIG 421 Query: 471 IFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVE 530 IF GY+++ +T I + WL GD G D G+ G +I I + G + P VE Sbjct: 422 IFSGYVDNPDKTAANIRGDFWL-LGDRGIKDEDGYFQFMGRADDI-INSSGYRIGPSEVE 479 Query: 531 TLVKKKIPIISNAML 545 + + ++ A++ Sbjct: 480 NALMEHPAVVETAVI 494 >gi|227499619 solute carrier family 27 (fatty acid transporter), member 2 isoform 1 [Homo sapiens] Length = 620 Score = 44.3 bits (103), Expect = 4e-04 Identities = 54/218 (24%), Positives = 89/218 (40%), Gaps = 15/218 (6%) Query: 79 EILNFNQYYEACRKAAKSLIK-LGLERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYA 137 E L + Q + A++L LGL + V +L N + +G + G + Sbjct: 77 ETLTYAQVDRRSNQVARALHDHLGLRQGDCVALLMGNEPAYVWLWLGLVKLGCAMACLNY 136 Query: 138 TNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKAIIQYRLPMKKNNNLYSW 197 A+ + +LLV + Q +P SL+ I Y + + +N Sbjct: 137 NIRAKSLLHCFQCCGAKVLLVSPELQAAVEEILP--SLKKDDVSIYY---VSRTSNTDGI 191 Query: 198 DDFMELGRSIPDTQLEQVIESQKANQC----AVLIYTSGTTGIPKGVMLSHDNITWIAGA 253 D F++ + + E + ES ++ A+ IYTSGTTG+PK M++H I + G Sbjct: 192 DSFLD---KVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGLPKAAMITHQRIWYGTGL 248 Query: 254 VTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGA 291 D + + LP H AA ++ I I GA Sbjct: 249 TFVSGLKAD--DVIYITLPFYHSAALLIGIHGCIVAGA 284 >gi|13325057 solute carrier family 27 (fatty acid transporter), member 5 [Homo sapiens] Length = 690 Score = 42.7 bits (99), Expect = 0.001 Identities = 23/72 (31%), Positives = 40/72 (55%), Gaps = 2/72 (2%) Query: 225 AVLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIW 284 A+ IYTSGTTG+PK +L+H+ + ++ ++ D + V + LPL H+ ++ I Sbjct: 290 ALFIYTSGTTGLPKPAILTHERVLQMSKMLSLSGATAD--DVVYTVLPLYHVMGLVVGIL 347 Query: 285 VPIKIGALTYFA 296 + +GA A Sbjct: 348 GCLDLGATCVLA 359 >gi|122937307 acyl-CoA synthetase medium-chain family member 4 [Homo sapiens] Length = 580 Score = 41.2 bits (95), Expect = 0.003 Identities = 101/502 (20%), Positives = 185/502 (36%), Gaps = 97/502 (19%) Query: 68 PALASKNGKKWEIL-NFNQYYEACRKAAKSLIK-LGLERFHGVGILGFNSAEWFITAVGA 125 PAL NGK E+ +F + RKAA L K GL+R + ++ EW++ V Sbjct: 75 PALWWVNGKGDEVKWSFRELGSLSRKAANVLTKPCGLQRGDRLAVILPRIPEWWLVNVAC 134 Query: 126 ILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKAIIQYR 185 I G + + +A+ Y + +K ++ + + P I Sbjct: 135 IRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASEE-------------VAPAVESIVLE 181 Query: 186 LPMKKNNNLYS---WDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGVML 242 P K L S W+ ++ E + + + +TSGTTG PK Sbjct: 182 CPDLKTKLLVSPQSWNGWLSFQELFQFASEEHSCVETGSQEPMTIYFTSGTTGFPKMAQH 241 Query: 243 SHDNI---TWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTY---FA 296 S ++ + G D K +D + + + A + ++ GA + A Sbjct: 242 SQSSLGIGFTLCGRYWLDLKSSD---IIWNMSDTGWVKAAIGSVFSSWLCGACVFVHRMA 298 Query: 297 QADALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKV 356 Q D T + TL T P ++ +V+K+ LK+ F Sbjct: 299 QFDT--DTFLDTLTTYPITTLCSPPTVYRM---LVQKD------LKRYKF---------- 337 Query: 357 NSKKMLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAE-FFLSLDIP 415 L HC ++G PLN E E + + + Sbjct: 338 -----------------------------KSLRHC---LTGGEPLNPEVLEQWRVQTGLE 365 Query: 416 IGELYGLSESSGPHTISNQNNYRLL--SCGKILTGCKNMLFQQNKDGI-----GEICLWG 468 + E YG +E +NQ + S GK + + +N + + GEI L Sbjct: 366 LYEGYGQTEVG--MICANQKGQEIKPGSMGKGMLPYDVQIIDENGNVLPPGKEGEIALRL 423 Query: 469 RH-----IFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGEN 523 + F Y+++ +T I + ++ +GD G +D G+ + G +++I++ G Sbjct: 424 KPTRPFCFFSKYVDNPQKTAATIRGDFYV-TGDRGVMDSDGYFWFVGRADDVIISS-GYR 481 Query: 524 VPPIPVETLVKKKIPIISNAML 545 + P VE+ + + ++ +A++ Sbjct: 482 IGPFEVESALIEHPAVVESAVV 503 >gi|13236579 solute carrier family 27 member 3 [Homo sapiens] Length = 730 Score = 40.4 bits (93), Expect = 0.005 Identities = 31/101 (30%), Positives = 48/101 (47%), Gaps = 7/101 (6%) Query: 219 QKANQCAVLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDKHETVVSY--LPLSHI 276 Q + I+TSGTTG+PK +SH I G ++L H+ V Y LPL H+ Sbjct: 324 QSITDTCLYIFTSGTTGLPKAARISHLKILQCQGF----YQLCGVHQEDVIYLALPLYHM 379 Query: 277 AAQMMDIWVPIKIGALTYFAQADALKGTLVSTLKEVKPTVF 317 + ++ I + IGA T ++ G ++ + TVF Sbjct: 380 SGSLLGIVGCMGIGA-TVVLKSKFSAGQFWEDCQQHRVTVF 419 >gi|40807357 solute carrier family 27 (fatty acid transporter), member 4 [Homo sapiens] Length = 643 Score = 38.5 bits (88), Expect = 0.020 Identities = 21/56 (37%), Positives = 31/56 (55%), Gaps = 1/56 (1%) Query: 228 IYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDI 283 IYTSGTTG+PK ++ H +A V F++ ++ V LPL H A ++ I Sbjct: 244 IYTSGTTGLPKAAIVVHSRYYRMAALVYYGFRMR-PNDIVYDCLPLYHSAGNIVGI 298 >gi|115511026 acyl-CoA synthetase medium-chain family member 1 [Homo sapiens] Length = 577 Score = 38.1 bits (87), Expect = 0.026 Identities = 46/189 (24%), Positives = 79/189 (41%), Gaps = 12/189 (6%) Query: 58 RESVNRFGTYPALASKNGKKWEIL-NFNQYYEACRKAAKSLIKL-GLERFHGVGILGFNS 115 +E + G PA NG+ E+ +F + + R+ A + GL++ + ++ Sbjct: 62 KEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRV 121 Query: 116 AEWFITAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSL 175 EW++ AVG + G + + A+ Y + +K + V D ++ SI S Sbjct: 122 PEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGI-VTIDALASEVDSIA-SQC 179 Query: 176 EPLKAIIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTG 235 LK + + +++ W DF L +S E K V+ +TSGTTG Sbjct: 180 PSLKTKL-----LVSDHSREGWLDFRSLVKSASP---EHTCVKSKTLDPMVIFFTSGTTG 231 Query: 236 IPKGVMLSH 244 PK SH Sbjct: 232 FPKMAKHSH 240 Score = 34.7 bits (78), Expect = 0.29 Identities = 22/77 (28%), Positives = 42/77 (54%), Gaps = 3/77 (3%) Query: 471 IFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVE 530 +FM Y E + E T ++ + ++GD G++D G++ G +I I A G + P VE Sbjct: 428 LFMCY-EGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDI-INASGYRIGPAEVE 485 Query: 531 TLVKKKIPIISNAMLVG 547 + + + P ++ + +VG Sbjct: 486 SALVEH-PAVAESAVVG 501 >gi|62865631 solute carrier family 27 (fatty acid transporter), member 6 [Homo sapiens] Length = 619 Score = 37.4 bits (85), Expect = 0.045 Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 3/110 (2%) Query: 228 IYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPI 287 I+TSGTTG+PK ++S + AV F T H+ V LPL H +A ++ I + Sbjct: 222 IFTSGTTGLPKAAVISQLQVL-RGSAVLWAFGCT-AHDIVYITLPLYHSSAAILGISGCV 279 Query: 288 KIGALTYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAK 337 ++GA T + S K+ TVF + ++ + + K+ K Sbjct: 280 ELGA-TCVLKKKFSASQFWSDCKKYDVTVFQYIGELCRYLCKQSKREGEK 328 >gi|13325055 solute carrier family 27 (fatty acid transporter), member 6 [Homo sapiens] Length = 619 Score = 37.4 bits (85), Expect = 0.045 Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 3/110 (2%) Query: 228 IYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPI 287 I+TSGTTG+PK ++S + AV F T H+ V LPL H +A ++ I + Sbjct: 222 IFTSGTTGLPKAAVISQLQVL-RGSAVLWAFGCT-AHDIVYITLPLYHSSAAILGISGCV 279 Query: 288 KIGALTYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAK 337 ++GA T + S K+ TVF + ++ + + K+ K Sbjct: 280 ELGA-TCVLKKKFSASQFWSDCKKYDVTVFQYIGELCRYLCKQSKREGEK 328 >gi|28416953 acyl-CoA synthetase short-chain family member 1 [Homo sapiens] Length = 689 Score = 35.8 bits (81), Expect = 0.13 Identities = 38/169 (22%), Positives = 74/169 (43%), Gaps = 12/169 (7%) Query: 81 LNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFITAVGAILA----GGLCVGIY 136 + + + E + A +L + G+ R V I S AV A+LA G + I+ Sbjct: 141 ITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSP----LAVAAMLACARIGAVHTVIF 196 Query: 137 ATNSAEVCQYVITHAKVNILLVENDQ----QLQKILSIPQSSLEPLKAIIQYRLPMKKNN 192 A SAE I AK +++ N ++ ++ I +++ + + + +N Sbjct: 197 AGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQHVLVAHRTDN 256 Query: 193 NLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGVM 241 ++ D + L + + ES + ++YTSG+TG+PKG++ Sbjct: 257 KVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIV 305 >gi|42544134 SA hypertension-associated homolog isoform 2 [Homo sapiens] Length = 438 Score = 32.7 bits (73), Expect = 1.1 Identities = 43/209 (20%), Positives = 83/209 (39%), Gaps = 26/209 (12%) Query: 53 IPEFF------------RESVNRFGTYPAL--ASKNGKKWEILNFNQYYEACRKAAKSLI 98 IPE+F +E + + PA ++NG++ +F + RK A L Sbjct: 54 IPEYFNFAKDVLDQWTDKEKAGKKPSNPAFWWINRNGEEMR-WSFEELGSLSRKFANILS 112 Query: 99 KL-GLERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILL 157 + L+R V ++ EW++ V + G + + + + Y + +K N ++ Sbjct: 113 EACSLQRGDRVILILPRVPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKANCII 172 Query: 158 VENDQQLQKILSIPQSSLEPLKAIIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIE 217 + L + S E L + + + N+ W + EL + D+ Sbjct: 173 TND--VLAPAVDAVASKCENLHSKL-----IVSENSREGWGNLKELMKHASDSH---TCV 222 Query: 218 SQKANQCAVLIYTSGTTGIPKGVMLSHDN 246 K N+ + +TSGT+G PK +H + Sbjct: 223 KTKHNEIMAIFFTSGTSGYPKMTAHTHSS 251 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.135 0.403 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 23,861,412 Number of Sequences: 37866 Number of extensions: 1003605 Number of successful extensions: 2342 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 21 Number of HSP's successfully gapped in prelim test: 19 Number of HSP's that attempted gapping in prelim test: 2243 Number of HSP's gapped (non-prelim): 49 length of query: 666 length of database: 18,247,518 effective HSP length: 109 effective length of query: 557 effective length of database: 14,120,124 effective search space: 7864909068 effective search space used: 7864909068 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.