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Search of human proteins with 7705748
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
(835 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 1695 0.0
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 1667 0.0
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 164 3e-40
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 159 1e-38
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 158 2e-38
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 157 3e-38
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 157 3e-38
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 157 3e-38
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 157 3e-38
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 157 3e-38
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 157 5e-38
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 157 5e-38
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 157 5e-38
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 155 1e-37
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 155 2e-37
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 155 2e-37
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 155 2e-37
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 155 2e-37
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 141 2e-33
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 141 2e-33
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 139 1e-32
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 137 4e-32
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 135 1e-31
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 135 2e-31
gi|62420875 integrin-linked kinase [Homo sapiens] 134 5e-31
gi|62420873 integrin-linked kinase [Homo sapiens] 134 5e-31
gi|4758606 integrin-linked kinase [Homo sapiens] 134 5e-31
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 131 2e-30
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 131 2e-30
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 131 3e-30
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 1695 bits (4390), Expect = 0.0
Identities = 835/835 (100%), Positives = 835/835 (100%)
Query: 1 MGNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNL 60
MGNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNL
Sbjct: 1 MGNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNL 60
Query: 61 NYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSL 120
NYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSL
Sbjct: 61 NYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSL 120
Query: 121 LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE 180
LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE
Sbjct: 121 LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE 180
Query: 181 QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH 240
QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH
Sbjct: 181 QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH 240
Query: 241 FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK 300
FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK
Sbjct: 241 FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK 300
Query: 301 ENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL 360
ENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL
Sbjct: 301 ENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL 360
Query: 361 DNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPG 420
DNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPG
Sbjct: 361 DNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPG 420
Query: 421 GDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKG 480
GDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKG
Sbjct: 421 GDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKG 480
Query: 481 RCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQ 540
RCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQ
Sbjct: 481 RCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQ 540
Query: 541 YISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDG 600
YISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDG
Sbjct: 541 YISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDG 600
Query: 601 HAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILT 660
HAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILT
Sbjct: 601 HAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILT 660
Query: 661 GEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLE 720
GEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLE
Sbjct: 661 GEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLE 720
Query: 721 ECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAA 780
ECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAA
Sbjct: 721 ECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAA 780
Query: 781 LSQSAGQYSSQGLSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS 835
LSQSAGQYSSQGLSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS
Sbjct: 781 LSQSAGQYSSQGLSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS 835
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 1667 bits (4317), Expect = 0.0
Identities = 822/823 (99%), Positives = 823/823 (100%)
Query: 13 TDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLH 72
+DEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLH
Sbjct: 114 SDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLH 173
Query: 73 LCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGY 132
LCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGY
Sbjct: 174 LCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGY 233
Query: 133 GGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGAD 192
GGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGAD
Sbjct: 234 GGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGAD 293
Query: 193 VNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVK 252
VNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVK
Sbjct: 294 VNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVK 353
Query: 253 YLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSA 312
YLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSA
Sbjct: 354 YLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSA 413
Query: 313 CTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACD 372
CTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACD
Sbjct: 414 CTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACD 473
Query: 373 PSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPL 432
PSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPL
Sbjct: 474 PSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPL 533
Query: 433 GKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRY 492
GKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRY
Sbjct: 534 GKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRY 593
Query: 493 RANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH 552
RANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH
Sbjct: 594 RANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH 653
Query: 553 EQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRF 612
EQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRF
Sbjct: 654 EQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRF 713
Query: 613 LQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAA 672
LQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAA
Sbjct: 714 LQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAA 773
Query: 673 AAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPA 732
AAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPA
Sbjct: 774 AAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPA 833
Query: 733 SSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAALSQSAGQYSSQG 792
SSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAALSQSAGQYSSQG
Sbjct: 834 SSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAALSQSAGQYSSQG 893
Query: 793 LSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS 835
LSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS
Sbjct: 894 LSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS 936
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 164 bits (415), Expect = 3e-40
Identities = 112/347 (32%), Positives = 171/347 (49%), Gaps = 17/347 (4%)
Query: 55 FSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNA 114
F K ++N++ + LH G + I L+L G R + T LH AV +
Sbjct: 29 FKKEDVNFQDNEKRTPLHAAAYLGDAEI-IELLILSGARVNAKDSKWLTPLHRAVASCSE 87
Query: 115 ELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIA 174
E + LL AD+ T LHIA ++ A+ L+ +NVN+ D T LH A
Sbjct: 88 EAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHA 147
Query: 175 AYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNE 234
A+ GH ++ +LLL GA++N + R +H A+ G + + KLL+ G A+V +D +
Sbjct: 148 AFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHG--AEVTCKDKK 205
Query: 235 DHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG 294
+ PLH + G +VKYLL DL V + N YG+TPLH+ACYNG+ V E+I
Sbjct: 206 SYTPLHAAASSGMISVVKYLL--DLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA 263
Query: 295 TESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIR 354
+ E F+ F +A T+G L LL N ++N + +DG T LH HG
Sbjct: 264 IVNQKNEKGFTPLHFAAASTHGA---LCLELLVGNGADVNMKSKDGKTPLHMTALHGRFS 320
Query: 355 LVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
Q ++ +GA ++ C+ +K+ T L A GH+ ++ L
Sbjct: 321 RSQTIIQSGA---VIDCE------DKNGNTPLHIAARYGHELLINTL 358
Score = 116 bits (290), Expect = 1e-25
Identities = 84/269 (31%), Positives = 126/269 (46%), Gaps = 7/269 (2%)
Query: 99 RNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGA 158
R G TALH A + + E++ LL GA+I A+H A GH+E +L+ HGA
Sbjct: 138 RAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 197
Query: 159 NVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKL 218
V +D +TPLH AA G V + LL G D+N G+ PLH+A G +
Sbjct: 198 EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNE 257
Query: 219 LMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLAC 278
L++ G A VN ++ + PLHF + H + LL + ++ + G TPLH+
Sbjct: 258 LIDCG--AIVNQKNEKGFTPLHFAAASTHGALCLELLVGN-GADVNMKSKDGKTPLHMTA 314
Query: 279 YNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGR 338
+G+F ++ IIQ +N T H A YG + L+ L+ + +G
Sbjct: 315 LHGRFSRSQTIIQSGAVIDCEDKN--GNTPLHIAARYGHEL-LINTLITSGA-DTAKRGI 370
Query: 339 DGHTGLHSACYHGHIRLVQFLLDNGADMN 367
G LH A G + LL +G D++
Sbjct: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDID 399
Score = 113 bits (282), Expect = 8e-25
Identities = 103/358 (28%), Positives = 163/358 (45%), Gaps = 30/358 (8%)
Query: 45 LRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTA 104
LR + G+ E + V++ + NG + L L + G + +L+ KG + G TA
Sbjct: 633 LRLLIGNAEPQNAVDI--QDGNGQTPLMLS-VLNGHTDCVYSLLNKGANVDAKDKWGRTA 689
Query: 105 LHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQD 164
LH + E + +LL GA G T +H++ GH+ LLQ A+++
Sbjct: 690 LHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANP 749
Query: 165 AVF----FTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLM 220
A +T LH A Y GHE LLL+ G PLH A A++L+
Sbjct: 750 ATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFS-PLHCAVINDNEGAAEMLI 808
Query: 221 EEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYN 280
+ + VNA D++ PLH + H + ++ LL + +V + V+ G TPL +A N
Sbjct: 809 DTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQV--NSVDSTGKTPLMMAAEN 866
Query: 281 GKFEVAKEIIQISGTESLTKENIFSETAFHSACTYG---KSIDLVKFLLDQNVININHQG 337
G+ E++ S + LT ++ TA H AC+ G ++ +++ + D+N+IN +
Sbjct: 867 GQTNTV-EMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAA 925
Query: 338 RDGHTGLHSACYHGHIRLVQFLLDNGADMNLV---------ACDPSRSSGEKDEQTCL 386
T LH A +G +VQ LL GA + V AC P+ KD CL
Sbjct: 926 L--QTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPN-----KDVADCL 976
Score = 112 bits (280), Expect = 1e-24
Identities = 93/319 (29%), Positives = 157/319 (49%), Gaps = 18/319 (5%)
Query: 59 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 118
++N ++++G + LH+ + G+ S +T++ G +NG T LH+A + LI
Sbjct: 298 DVNMKSKDGKTPLHMTAL-HGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLIN 356
Query: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
+L+ SGAD + G G+ LH+A ++G + LL G +++ D T LH AA G
Sbjct: 357 TLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGG 416
Query: 179 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238
+ + LLL GAD N + G PLH A+A N L GS A VN D P
Sbjct: 417 NLECLNLLLNTGADFNKKDKFGRSPLHYAAAN--CNYQCLFALVGSGASVNDLDERGCTP 474
Query: 239 LHFCSRFG-HHDIVKYLLQSDLEVQPHVVNIYGDTPLHL-ACYNGKF---EVAKE----- 288
LH+ + ++YLL++D P + + G +H A Y + +A E
Sbjct: 475 LHYAATSDTDGKCLEYLLRND--ANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDV 532
Query: 289 IIQISGTESLT-KENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSA 347
+++ SGT+ L+ +N + + H A +G L +L Q++++++ + G T L A
Sbjct: 533 LMETSGTDMLSDSDNRATISPLHLAAYHGHHQALE--VLVQSLLDLDVRNSSGRTPLDLA 590
Query: 348 CYHGHIRLVQFLLDNGADM 366
+ GH+ V L++ GA +
Sbjct: 591 AFKGHVECVDVLINQGASI 609
Score = 108 bits (271), Expect = 2e-23
Identities = 93/343 (27%), Positives = 143/343 (41%), Gaps = 55/343 (16%)
Query: 99 RNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGA 158
R + LHLA Y + + + L+ S D+ G T L +A GH+E DVL+ GA
Sbjct: 548 RATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGA 607
Query: 159 NVNIQDAVF-FTPLHIAAYYGHEQVTRL-------------------------------- 185
++ ++D + TP+H AA GH + RL
Sbjct: 608 SILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTD 667
Query: 186 ----LLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 241
LL GA+V+ + G LH + G L++ G+K + +D+ P+H
Sbjct: 668 CVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLL--RDSRGRTPIHL 725
Query: 242 CSRFGHHDIVKYLLQS--DLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLT 299
+ GH ++ LLQS ++ P + +G T LH ACYNG E E++ T
Sbjct: 726 SAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNG-HETCVELLLEQEVFQKT 784
Query: 300 KENIFSETAFHSACTYGKSIDLVKFLLDQ-NVININHQGRDGHTGLHSACYHGHIRLVQF 358
+ N FS H A + + L+D +N G T LH+A + H+ +Q
Sbjct: 785 EGNAFS--PLHCA-VINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQL 841
Query: 359 LLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
LL + A +N V + +T LM A E G V +L
Sbjct: 842 LLSHNAQVNSV---------DSTGKTPLMMAAENGQTNTVEML 875
Score = 105 bits (263), Expect = 1e-22
Identities = 124/483 (25%), Positives = 179/483 (37%), Gaps = 120/483 (24%)
Query: 34 DLQIKEKE------LTELRNIFGSDEAF--SKVNLNYRTENGLSLLHLCCICGGKKSHIR 85
D+ +K K+ +T L F + S ++ +NG + LH+ G + I
Sbjct: 298 DVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELL-IN 356
Query: 86 TLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAG 145
TL+ G ++ +G LHLA ++ LL SG DI G T LH A G
Sbjct: 357 TLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGG 416
Query: 146 HLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLH 205
+LE ++LL GA+ N +D +PLH AA + Q L+ GA VN E G PLH
Sbjct: 417 NLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLH 476
Query: 206 LASA-----------------------KGFLNI--------------------AKLLMEE 222
A+ +G+ + +LME
Sbjct: 477 YAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMET 536
Query: 223 GSKADVNAQDNEDHV-PLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNG 281
++ DN + PLH + GHH ++ L+QS L++ V N G TPL LA + G
Sbjct: 537 SGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLD--VRNSSGRTPLDLAAFKG 594
Query: 282 KFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKS----------------------- 318
E +I G L K+ I T H+A T G S
Sbjct: 595 HVECVDVLIN-QGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNG 653
Query: 319 ------------IDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADM 366
D V LL++ N++ + + G T LH GH V LL +GA
Sbjct: 654 QTPLMLSVLNGHTDCVYSLLNKGA-NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKC 712
Query: 367 NL------------VAC----------------DPSRSSGEKDEQTCLMWAYEKGHDAIV 398
L AC D + ++ + T L WA GH+ V
Sbjct: 713 LLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCV 772
Query: 399 TLL 401
LL
Sbjct: 773 ELL 775
Score = 91.3 bits (225), Expect = 3e-18
Identities = 91/353 (25%), Positives = 146/353 (41%), Gaps = 26/353 (7%)
Query: 60 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 119
+N + E G + LH + L+ G + +++G T LH+ +
Sbjct: 265 VNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQT 324
Query: 120 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 179
++ SGA I G T LHIA GH + L+ GA+ + PLH+AA G
Sbjct: 325 IIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGF 384
Query: 180 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPL 239
R LL G D++ + G LH A+A G L LL+ G AD N +D PL
Sbjct: 385 SDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTG--ADFNKKDKFGRSPL 442
Query: 240 HFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLT 299
H+ + ++ + L+ S V ++ G TPLH A + E + +
Sbjct: 443 HYAAANCNYQCLFALVGSGASVND--LDERGCTPLHYAATSDTDGKCLEYLLRNDANPGI 500
Query: 300 KENIFSETAFHSACTYGKSIDLVKFLLDQNVINI-----------NHQGRDGHTGLHSAC 348
++ A H + YG + L + + + +++ + R + LH A
Sbjct: 501 RDK-QGYNAVHYSAAYGHRLCL-QLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA 558
Query: 349 YHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
YHGH + ++ L+ + D+ D SSG +T L A KGH V +L
Sbjct: 559 YHGHHQALEVLVQSLLDL-----DVRNSSG----RTPLDLAAFKGHVECVDVL 602
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 159 bits (401), Expect = 1e-38
Identities = 105/332 (31%), Positives = 164/332 (49%), Gaps = 17/332 (5%)
Query: 71 LHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQV 130
LH+ G + I L+L G R + T LH AV + E + L+ AD+
Sbjct: 20 LHVAAFLGDAEI-IELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNAR 78
Query: 131 GYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFG 190
T LH+A ++ A+V++ ++VN+ D T LH AA GH ++ LLL G
Sbjct: 79 DKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKG 138
Query: 191 ADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDI 250
A++N + R LH A+ G L++ LL+ G A+V +D + + PLH + G ++
Sbjct: 139 ANINAFDKKDRRALHWAAYMGHLDVVALLINHG--AEVTCKDKKGYTPLHAAASNGQINV 196
Query: 251 VKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFH 310
VK+LL +E+ +N+YG+T LH+ACYNG+ V E+I + N F+ F
Sbjct: 197 VKHLLNLGVEIDE--INVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFA 254
Query: 311 SACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVA 370
+A T+G L LL N ++N Q +DG + LH HG Q L+ NG +++ V
Sbjct: 255 AASTHGA---LCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCV- 310
Query: 371 CDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLK 402
+KD T L A GH+ ++ L+
Sbjct: 311 --------DKDGNTPLHVAARYGHELLINTLR 334
Score = 107 bits (266), Expect = 6e-23
Identities = 86/323 (26%), Positives = 141/323 (43%), Gaps = 36/323 (11%)
Query: 67 GLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL-HSGA 125
G + LH+ C G+ + + L+ G ++ NGFT LH A + L LL ++GA
Sbjct: 214 GNTALHIACY-NGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGA 272
Query: 126 DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRL 185
D+ G + LH+ + G + L+Q+G ++ D TPLH+AA YGHE +
Sbjct: 273 DVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINT 332
Query: 186 LLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRF 245
L GAD G PLHLA+ + + L+ G +++ D LH +
Sbjct: 333 LRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSG--FEIDTPDKFGRTCLHAAAAG 390
Query: 246 GHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFS 305
G+ + +K L S + H + G TPLH A N F + ++ + T + +
Sbjct: 391 GNVECIKLLQSSGADF--HKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDD--WG 446
Query: 306 ETAFHSACT---------YGKSID------------------LVKFLLDQNVININHQGR 338
TA H A G + D ++FLL QN N + + +
Sbjct: 447 RTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLL-QNDANPSIRDK 505
Query: 339 DGHTGLHSACYHGHIRLVQFLLD 361
+G+ +H A +GH + ++ LL+
Sbjct: 506 EGYNSIHYAAAYGHRQCLELLLE 528
Score = 95.5 bits (236), Expect = 2e-19
Identities = 87/360 (24%), Positives = 158/360 (43%), Gaps = 39/360 (10%)
Query: 59 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 118
++N ++++G S LH+ + G+ + +TL+ G + ++G T LH+A + LI
Sbjct: 273 DVNIQSKDGKSPLHMTAV-HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLIN 331
Query: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
+L SGAD + G + LH+A + H + LL G ++ D T LH AA G
Sbjct: 332 TLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGG 391
Query: 179 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238
+ + +LL GAD + + G PLH A+A + + L+ G A+VN D+
Sbjct: 392 NVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTG--ANVNETDDWGRTA 449
Query: 239 LHFCSRF----------GHHD------------------IVKYLLQSDLEVQPHVVNIYG 270
LH+ + HD +++LLQ+D P + + G
Sbjct: 450 LHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQND--ANPSIRDKEG 507
Query: 271 DTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNV 330
+H A G + + +++ + + ++ +++ H A G L L Q++
Sbjct: 508 YNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLL--QSL 565
Query: 331 ININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADM----NLVACDPSRSSGEKDEQTCL 386
++++ + G T L A + GH V+ L++ GA + N+ P +S CL
Sbjct: 566 VDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCL 625
Score = 92.4 bits (228), Expect = 2e-18
Identities = 97/367 (26%), Positives = 161/367 (43%), Gaps = 25/367 (6%)
Query: 56 SKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLR---PSRLTRNGFTALHLAVYKD 112
S V+L+ R E G + L L G + + L+ G +T+ T LH +V
Sbjct: 564 SLVDLDIRDEKGRTALDLAAFKGHTEC-VEALINPGASIFVKDNVTKR--TPLHASVING 620
Query: 113 NAELITSLLHSGADIQQVGYG---GLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFT 169
+ + LL + + V G T L +A GH++A +LL+ ANV+ D + T
Sbjct: 621 HTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCT 680
Query: 170 PLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLN-IAKLLMEEGSKADV 228
LH GHE+ ++LL+ + G PLH A+A+G +++LL S+ D
Sbjct: 681 ALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDC 740
Query: 229 NAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKE 288
+DN+ + PLH+ G+ + ++ LL+ + + N + TPLH A N A
Sbjct: 741 CFKDNQGYTPLHWACYNGNENCIEVLLEQKC-FRKFIGNPF--TPLHCAIINDHGNCASL 797
Query: 289 IIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSAC 348
++ + ++ + T +A + ++ ++ LL ++ +N G T L A
Sbjct: 798 LLGAIDSSIVSCRDDKGRTPLRAA-AFADHVECLQLLL-RHSAPVNAVDNSGKTALMMAA 855
Query: 349 YHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQ 408
+G V L+ N A +L D KD T L A KGH+ L+ + Q
Sbjct: 856 ENGQAGAVDILV-NSAQADLTVKD-------KDLNTPLHLACSKGHEKCALLI--LDKIQ 905
Query: 409 DELPCNE 415
DE NE
Sbjct: 906 DESLINE 912
Score = 90.5 bits (223), Expect = 6e-18
Identities = 93/349 (26%), Positives = 146/349 (41%), Gaps = 35/349 (10%)
Query: 79 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 138
G + I TL G ++ + LHLA +++ LL SG +I G T L
Sbjct: 325 GHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCL 384
Query: 139 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGE 198
H A G++E +L GA+ + +D TPLH AA H L+ GA+VN + +
Sbjct: 385 HAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDD 444
Query: 199 VGDRPLHLASAKGF----------------LNIAKLLMEE----------GSKADVNAQD 232
G LH A+A L A+ L E+ + A+ + +D
Sbjct: 445 WGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRD 504
Query: 233 NEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQI 292
E + +H+ + +GH ++ LL+ + +PLHLA YNG + + ++Q
Sbjct: 505 KEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQS 564
Query: 293 SGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGH 352
+ E TA A G + + V+ L++ T LH++ +GH
Sbjct: 565 LVDLDIRDEK--GRTALDLAAFKGHT-ECVEALINPGASIFVKDNVTKRTPLHASVINGH 621
Query: 353 IRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
++ LL+ AD N A D + G QT LM A GH V+LL
Sbjct: 622 TLCLRLLLEI-AD-NPEAVDVKDAKG----QTPLMLAVAYGHIDAVSLL 664
Score = 79.7 bits (195), Expect = 1e-14
Identities = 73/249 (29%), Positives = 110/249 (44%), Gaps = 41/249 (16%)
Query: 152 VLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKG 211
+L+ +VN D+ TPLH+AA+ G ++ LL+ GA VN + PLH A A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 212 FLNIAKLLMEEGSKADVNAQDNEDHVPLHF--------CSRF------------------ 245
++L++ ADVNA+D PLH C+
Sbjct: 61 SEEAVQVLIKH--SADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTA 118
Query: 246 -------GHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESL 298
GH ++V LL + + + LH A Y G +V +I G E
Sbjct: 119 LHHAALNGHVEMVNLLLAKGANI--NAFDKKDRRALHWAAYMGHLDVVALLIN-HGAEVT 175
Query: 299 TKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQF 358
K+ T H+A + G+ I++VK LL+ V I+ G+T LH ACY+G +V
Sbjct: 176 CKDK-KGYTPLHAAASNGQ-INVVKHLLNLGV-EIDEINVYGNTALHIACYNGQDAVVNE 232
Query: 359 LLDNGADMN 367
L+D GA++N
Sbjct: 233 LIDYGANVN 241
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 158 bits (399), Expect = 2e-38
Identities = 102/301 (33%), Positives = 162/301 (53%), Gaps = 10/301 (3%)
Query: 79 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 138
GK ++ L+ +G P+ T +G+T LHL+ + + ++ LL GA + G T L
Sbjct: 510 GKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPL 569
Query: 139 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGE 198
H+A G LE A++LLQ A+ + TPLH+AA+Y +++V LLL GA + + +
Sbjct: 570 HVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAK 629
Query: 199 VGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSD 258
G PLH+A+ K ++IA L+E G AD NA + +H ++ GH D+V LL +
Sbjct: 630 NGYTPLHIAAKKNQMDIATTLLEYG--ADANAVTRQGIASVHLAAQEGHVDMVSLLLGRN 687
Query: 259 LEVQPHVVNIYGDTPLHLACYNGKFEVAKEII-QISGTESLTKENIFSETAFHSACTYGK 317
V ++ N G TPLHLA + VA+ ++ Q + ++ TK T H C YG
Sbjct: 688 ANV--NLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK---MGYTPLHVGCHYG- 741
Query: 318 SIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSS 377
+I +V FLL Q+ +N + ++G+T LH A GH ++ LL N A N + + + +
Sbjct: 742 NIKIVNFLL-QHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTAL 800
Query: 378 G 378
G
Sbjct: 801 G 801
Score = 152 bits (385), Expect = 9e-37
Identities = 107/338 (31%), Positives = 164/338 (48%), Gaps = 18/338 (5%)
Query: 64 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 123
T + L+ LH+ CG K + L+ K P+ NGFT LH+A K+ +++ LL
Sbjct: 364 TNDYLTALHVAAHCGHYKV-AKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKH 422
Query: 124 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 183
GA IQ V GLT +H+A GH+ L+ HGA+ N + T LH+AA G +V
Sbjct: 423 GASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVV 482
Query: 184 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 243
R L++ GA V + PLH+++ G +I + L+++G A NA + PLH +
Sbjct: 483 RYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQG--ASPNAATTSGYTPLHLSA 540
Query: 244 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENI 303
R GH D+ +LL + + G TPLH+A GK EVA ++Q S + ++
Sbjct: 541 REGHEDVAAFLLDHGASLS--ITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKS- 597
Query: 304 FSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNG 363
T H A Y + LLDQ + + ++G+T LH A + + LL+ G
Sbjct: 598 -GLTPLHVAAHYDNQ-KVALLLLDQGA-SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG 654
Query: 364 ADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
AD N V + + A ++GH +V+LL
Sbjct: 655 ADANAVT---------RQGIASVHLAAQEGHVDMVSLL 683
Score = 150 bits (378), Expect = 6e-36
Identities = 108/384 (28%), Positives = 177/384 (46%), Gaps = 51/384 (13%)
Query: 64 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 123
TE+GL+ +H+ G + + LM G P+ G TALH+A AE++ L+
Sbjct: 430 TESGLTPIHVAAFMG-HVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488
Query: 124 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 183
GA ++ T LHI+ G + LLQ GA+ N +TPLH++A GHE V
Sbjct: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548
Query: 184 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 243
LL GA ++++ + G PLH+A+ G L +A LL+++ + D A PLH +
Sbjct: 549 AFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD--AAGKSGLTPLHVAA 606
Query: 244 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQI-SGTESLTKEN 302
+ + + LL D PH G TPLH+A + ++A +++ + ++T++
Sbjct: 607 HYDNQKVALLLL--DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQG 664
Query: 303 IFSETAFHSACTYGKSIDLVKFLLDQNV-------------------------------- 330
I S H A G +D+V LL +N
Sbjct: 665 IAS---VHLAAQEG-HVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG 720
Query: 331 ININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAY 390
+++ Q + G+T LH C++G+I++V FLL + A +N + K+ T L A
Sbjct: 721 AHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN---------AKTKNGYTPLHQAA 771
Query: 391 EKGHDAIVTLLKHYKRPQDELPCN 414
++GH I+ +L +EL N
Sbjct: 772 QQGHTHIINVLLQNNASPNELTVN 795
Score = 145 bits (366), Expect = 2e-34
Identities = 110/397 (27%), Positives = 182/397 (45%), Gaps = 33/397 (8%)
Query: 60 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 119
+++ N ++ LH+ G + ++ L+ +G + TR+G T LH + +++
Sbjct: 261 VDFTARNDITPLHVASK-RGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEM 319
Query: 120 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 179
LL A I GL+ LH+AT HL +LLQH V+ + T LH+AA+ GH
Sbjct: 320 LLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGH 379
Query: 180 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPL 239
+V ++LL A+ N G PLH+A K + + +LL++ G A + A P+
Sbjct: 380 YKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHG--ASIQAVTESGLTPI 437
Query: 240 HFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG-TESL 298
H + GH +IV L+ P+ N+ G+T LH+A +G+ EV + ++Q E+
Sbjct: 438 HVAAFMGHVNIVSQLMHHG--ASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAK 495
Query: 299 TKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQF 358
K++ +T H + GK+ D+V+ LL Q + N G+T LH + GH + F
Sbjct: 496 AKDD---QTPLHISARLGKA-DIVQQLLQQGA-SPNAATTSGYTPLHLSAREGHEDVAAF 550
Query: 359 LLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQ 418
LLD+GA +++ +KG + K+ K L + +
Sbjct: 551 LLDHGASLSITT--------------------KKGFTPLHVAAKYGKLEVANLLLQKSAS 590
Query: 419 PGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSH 455
P G S +PL +K +LLL G H
Sbjct: 591 PDAAGK--SGLTPLHVAAHYDNQKVALLLLDQGASPH 625
Score = 137 bits (345), Expect = 4e-32
Identities = 106/318 (33%), Positives = 155/318 (48%), Gaps = 22/318 (6%)
Query: 99 RNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGA 158
+NG ALHLA + + E+++ LL A++ G TALHIA++AG E VL+ +GA
Sbjct: 72 QNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGA 131
Query: 159 NVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKL 218
NVN Q FTPL++AA H +V + LL GA +++ E G PL +A +G + L
Sbjct: 132 NVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSL 191
Query: 219 LMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLAC 278
L+E +K V LH +R LLQ+D V + G TPLH+A
Sbjct: 192 LLENDTKGKVRLP------ALHIAARKDDTKAAALLLQNDNNAD--VESKSGFTPLHIAA 243
Query: 279 YNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGR 338
+ G VA ++ + T N T H A G + ++VK LLD+ I+ + R
Sbjct: 244 HYGNINVATLLLNRAAAVDFTARN--DITPLHVASKRGNA-NMVKLLLDRGA-KIDAKTR 299
Query: 339 DGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIV 398
DG T LH GH ++V+ LLD A + S K+ + L A + H V
Sbjct: 300 DGLTPLHCGARSGHEQVVEMLLDRAAPI---------LSKTKNGLSPLHMATQGDHLNCV 350
Query: 399 TLLKHYKRPQDELPCNEY 416
LL + P D++ N+Y
Sbjct: 351 QLLLQHNVPVDDV-TNDY 367
Score = 129 bits (323), Expect = 1e-29
Identities = 101/346 (29%), Positives = 163/346 (47%), Gaps = 46/346 (13%)
Query: 58 VNLNYRTENGLSLLHLCCICGGKKSHIRT---LMLKGLRPSRLTRNGFTALHLAVYKDNA 114
V++N +NGL+ LHL K+ H+ L+ + T+ G TALH+A A
Sbjct: 65 VDINICNQNGLNALHLA----SKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQA 120
Query: 115 ELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIA 174
E++ L+ +GA++ G T L++A HLE LL +GA+ ++ FTPL +A
Sbjct: 121 EVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180
Query: 175 AYYGHEQVTRLLLKFGA-----------------------------DVNVSGEVGDRPLH 205
GH+QV LLL+ + +V + G PLH
Sbjct: 181 LQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLH 240
Query: 206 LASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHV 265
+A+ G +N+A LL+ + D A++ D PLH S+ G+ ++VK LL ++
Sbjct: 241 IAAHYGNINVATLLLNRAAAVDFTARN--DITPLHVASKRGNANMVKLLLDRGAKIDAKT 298
Query: 266 VNIYGDTPLHLACYNGKFEVAKEII-QISGTESLTKENIFSETAFHSACTYGKSIDLVKF 324
+ G TPLH +G +V + ++ + + S TK + + H A T G ++ V+
Sbjct: 299 RD--GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGL---SPLHMA-TQGDHLNCVQL 352
Query: 325 LLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVA 370
LL NV ++ D T LH A + GH ++ + LLD A+ N A
Sbjct: 353 LLQHNV-PVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKA 397
Score = 123 bits (308), Expect = 8e-28
Identities = 89/305 (29%), Positives = 147/305 (48%), Gaps = 19/305 (6%)
Query: 98 TRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHG 157
+++GFT LH+A + N + T LL+ A + +T LH+A+ G+ +LL G
Sbjct: 232 SKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRG 291
Query: 158 ANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 217
A ++ + TPLH A GHEQV +LL A + + G PLH+A+ LN +
Sbjct: 292 AKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQ 351
Query: 218 LLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLA 277
LL++ V+ N+ LH + GH+ + K LL D + P+ + G TPLH+A
Sbjct: 352 LLLQH--NVPVDDVTNDYLTALHVAAHCGHYKVAKVLL--DKKANPNAKALNGFTPLHIA 407
Query: 278 CYNGKFEVAKEIIQISGT-ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQ 336
C + +V + +++ + +++T+ + T H A G +++V L+ + N
Sbjct: 408 CKKNRIKVMELLLKHGASIQAVTESGL---TPIHVAAFMG-HVNIVSQLMHHGA-SPNTT 462
Query: 337 GRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDA 396
G T LH A G +V++L+ +GA + A KD+QT L + G
Sbjct: 463 NVRGETALHMAARSGQAEVVRYLVQDGAQVEAKA---------KDDQTPLHISARLGKAD 513
Query: 397 IVTLL 401
IV L
Sbjct: 514 IVQQL 518
Score = 94.7 bits (234), Expect = 3e-19
Identities = 79/261 (30%), Positives = 129/261 (49%), Gaps = 21/261 (8%)
Query: 141 ATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVG 200
A AGHLE A +++G ++NI + LH+A+ GH +V LL+ A+V+ + + G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 201 DRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLE 260
+ LH+AS G + K+L+ G A+VNAQ PL+ ++ H ++VK+LL D
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNG--ANVNAQSQNGFTPLYMAAQENHLEVVKFLL--DNG 163
Query: 261 VQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSID 320
+ G TPL +A G +V ++ E+ TK + A H A K
Sbjct: 164 ASQSLATEDGFTPLAVALQQGHDQVVSLLL-----ENDTKGKV-RLPALHIAAR--KDDT 215
Query: 321 LVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEK 380
LL QN N + + + G T LH A ++G+I + LL+ A ++ A +
Sbjct: 216 KAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA---------R 266
Query: 381 DEQTCLMWAYEKGHDAIVTLL 401
++ T L A ++G+ +V LL
Sbjct: 267 NDITPLHVASKRGNANMVKLL 287
Score = 76.6 bits (187), Expect = 9e-14
Identities = 50/181 (27%), Positives = 86/181 (47%), Gaps = 4/181 (2%)
Query: 61 NYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSL 120
N T G++ +HL G + L+ + + ++G T LHLA +D + L
Sbjct: 658 NAVTRQGIASVHLAAQ-EGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVL 716
Query: 121 LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE 180
++ GA + G T LH+ G+++ + LLQH A VN + +TPLH AA GH
Sbjct: 717 VNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHT 776
Query: 181 QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIA---KLLMEEGSKADVNAQDNEDHV 237
+ +LL+ A N G+ L +A G++++ K++ EE + ++ +V
Sbjct: 777 HIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNV 836
Query: 238 P 238
P
Sbjct: 837 P 837
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 157 bits (398), Expect = 3e-38
Identities = 108/336 (32%), Positives = 166/336 (49%), Gaps = 46/336 (13%)
Query: 63 RTENGLSLLHLCCICGGKKSHIRT---LMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 119
+T++ L+ LH C + H+R L+ G T+NG + +H+A D+ + +
Sbjct: 301 KTKDELTPLH----CAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 356
Query: 120 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 179
LL A+I + LT LH+A GH A VLL GA N + FTPLHIA H
Sbjct: 357 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 416
Query: 180 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEG---------------- 223
+V LLLK GA ++ E G PLH+AS G L I K L++ G
Sbjct: 417 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 476
Query: 224 ---------------SKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNI 268
+KA VNA+ +D PLH +R GH ++VK LL+++ P++
Sbjct: 477 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN--ANPNLATT 534
Query: 269 YGDTPLHLACYNGKFEVAKEIIQISGTES-LTKENIFSETAFHSACTYGKSIDLVKFLLD 327
G TPLH+A G E +++ +++ +TK+ T H A YGK + + + LL+
Sbjct: 535 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF---TPLHVAAKYGK-VRVAELLLE 590
Query: 328 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNG 363
++ + N G++G T LH A +H ++ +V+ LL G
Sbjct: 591 RDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 625
Score = 157 bits (397), Expect = 4e-38
Identities = 120/373 (32%), Positives = 173/373 (46%), Gaps = 50/373 (13%)
Query: 64 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 123
T + L+ LH+ CG + + L+ KG +P+ NGFT LH+A K++ ++ LL +
Sbjct: 368 TLDHLTPLHVAAHCGHHRV-AKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 426
Query: 124 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 183
GA I V GLT LH+A+ GHL LLQ GA+ N+ + TPLH+AA GH +V
Sbjct: 427 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 486
Query: 184 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 243
+ LL+ A VN + PLH A+ G N+ KLL+E + A+ N H PLH +
Sbjct: 487 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE--NNANPNLATTAGHTPLHIAA 544
Query: 244 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENI 303
R GH + V LL+ E + G TPLH+A GK VA+ +++ + +N
Sbjct: 545 REGHVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN- 601
Query: 304 FSETAFHSACTYGKSIDLVKFLL---------------------DQNVINI--------- 333
T H A + ++D+VK LL QN + +
Sbjct: 602 -GLTPLHVA-VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 659
Query: 334 --NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYE 391
N + G T LH A GH +V LL A+ NL G K T L +
Sbjct: 660 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---------GNKSGLTPLHLVAQ 710
Query: 392 KGHDAIV-TLLKH 403
+GH + L+KH
Sbjct: 711 EGHVPVADVLIKH 723
Score = 154 bits (388), Expect = 4e-37
Identities = 104/306 (33%), Positives = 156/306 (50%), Gaps = 9/306 (2%)
Query: 59 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 118
++N+ +NG++ LH+ G +R L+ +G + T++ T LH A + +
Sbjct: 264 SVNFTPQNGITPLHIASR-RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 322
Query: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
LL GA IQ GL+ +H+A HL+ +LLQ+ A ++ TPLH+AA+ G
Sbjct: 323 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 382
Query: 179 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238
H +V ++LL GA N G PLH+A K + + +LL++ G A ++A P
Sbjct: 383 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG--ASIDAVTESGLTP 440
Query: 239 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESL 298
LH S GH IVK LLQ P+V N+ +TPLH+A G EVAK ++Q +
Sbjct: 441 LHVASFMGHLPIVKNLLQRG--ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 498
Query: 299 TKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQF 358
++ +T H A G + ++VK LL+ N N N GHT LH A GH+ V
Sbjct: 499 KAKD--DQTPLHCAARIGHT-NMVKLLLENNA-NPNLATTAGHTPLHIAAREGHVETVLA 554
Query: 359 LLDNGA 364
LL+ A
Sbjct: 555 LLEKEA 560
Score = 141 bits (355), Expect = 3e-33
Identities = 96/341 (28%), Positives = 160/341 (46%), Gaps = 38/341 (11%)
Query: 60 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKG-LRPSRLTRNGFTALHLAVYKDNAELIT 118
+NY T+ + L L + ++L+ P L++ GFT LH+A + +N +
Sbjct: 197 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 256
Query: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
LL+ GA + G+T LHIA+ G++ +LL GA + + TPLH AA G
Sbjct: 257 LLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNG 316
Query: 179 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238
H +++ +LL GA + + G P+H+A+ L+ +LL++ ++ D D+ P
Sbjct: 317 HVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--LTP 374
Query: 239 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY----------------------------- 269
LH + GHH + K LL + +N +
Sbjct: 375 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 434
Query: 270 --GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD 327
G TPLH+A + G + K ++Q + +++ N+ ET H A G + ++ K+LL
Sbjct: 435 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPLHMAARAGHT-EVAKYLL- 490
Query: 328 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368
QN +N + +D T LH A GH +V+ LL+N A+ NL
Sbjct: 491 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 531
Score = 140 bits (353), Expect = 5e-33
Identities = 118/407 (28%), Positives = 182/407 (44%), Gaps = 84/407 (20%)
Query: 61 NYRTENGLSLLHLCCICGGKKSHIRT--LMLK-GLRPSRLTRNGFTALHLAVYKDNAELI 117
N R NG + LH+ C KK+H+R L+LK G +T +G T LH+A + + ++
Sbjct: 398 NSRALNGFTPLHIAC----KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 453
Query: 118 TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 177
+LL GA T LH+A AGH E A LLQ+ A VN + TPLH AA
Sbjct: 454 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 513
Query: 178 GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHV 237
GH + +LLL+ A+ N++ G PLH+A+ +G + L+E+ +A +
Sbjct: 514 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK--EASQACMTKKGFT 571
Query: 238 PLHFCSRFGHHDIVKYLLQSD----------------------LEV---------QPHVV 266
PLH +++G + + LL+ D L++ PH
Sbjct: 572 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 631
Query: 267 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL 326
G TPLH+A + EVA+ ++Q G S E++ T H A G + ++V LL
Sbjct: 632 AWNGYTPLHIAAKQNQVEVARSLLQYGG--SANAESVQGVTPLHLAAQEGHA-EMVALLL 688
Query: 327 DQNV--------------------------------ININHQGRDGHTGLHSACYHGHIR 354
+ + ++ R G+T LH A ++G+I+
Sbjct: 689 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 748
Query: 355 LVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
LV+FLL + AD+N + K + L A ++GH IVTLL
Sbjct: 749 LVKFLLQHQADVN---------AKTKLGYSPLHQAAQQGHTDIVTLL 786
Score = 140 bits (352), Expect = 6e-33
Identities = 98/317 (30%), Positives = 157/317 (49%), Gaps = 9/317 (2%)
Query: 56 SKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAE 115
+K +N + ++ + LH C G + ++ L+ P+ T G T LH+A + + E
Sbjct: 492 NKAKVNAKAKDDQTPLH-CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 550
Query: 116 LITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 175
+ +LL A + G T LH+A G + A++LL+ A+ N TPLH+A
Sbjct: 551 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 610
Query: 176 YYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 235
++ + + +LLL G + G PLH+A+ + + +A+ L++ G A NA+ +
Sbjct: 611 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQG 668
Query: 236 HVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGT 295
PLH ++ GH ++V LL + ++ N G TPLHL G VA +I+
Sbjct: 669 VTPLHLAAQEGHAEMVALLLSK--QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 726
Query: 296 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 355
T T H A YG +I LVKFLL Q+ ++N + + G++ LH A GH +
Sbjct: 727 VDATTR--MGYTPLHVASHYG-NIKLVKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDI 782
Query: 356 VQFLLDNGADMNLVACD 372
V LL NGA N V+ D
Sbjct: 783 VTLLLKNGASPNEVSSD 799
Score = 136 bits (343), Expect = 7e-32
Identities = 94/274 (34%), Positives = 141/274 (51%), Gaps = 12/274 (4%)
Query: 91 GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAA 150
G+ + +NG LHLA + + +++ LLH ++ G TALHIA +AG E
Sbjct: 68 GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 127
Query: 151 DVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAK 210
L+ +GANVN Q FTPL++AA H +V + LL+ GA+ NV+ E G PL +A +
Sbjct: 128 RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 187
Query: 211 GFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYG 270
G N+ L+ G+K V LH +R LLQ+D P V++ G
Sbjct: 188 GHENVVAHLINYGTKGKVRLP------ALHIAARNDDTRTAAVLLQND--PNPDVLSKTG 239
Query: 271 DTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNV 330
TPLH+A + VA+ ++ + + T +N T H A G I +V+ LLD+
Sbjct: 240 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASRRGNVI-MVRLLLDRGA 296
Query: 331 ININHQGRDGHTGLHSACYHGHIRLVQFLLDNGA 364
I + +D T LH A +GH+R+ + LLD+GA
Sbjct: 297 -QIETKTKDELTPLHCAARNGHVRISEILLDHGA 329
Score = 136 bits (342), Expect = 9e-32
Identities = 102/343 (29%), Positives = 170/343 (49%), Gaps = 40/343 (11%)
Query: 57 KVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAEL 116
++ L T+ G + LH+ + G + +R L+ G + ++ GFT L++A +++ E+
Sbjct: 101 EIILETTTKKGNTALHIAALAG-QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 159
Query: 117 ITSLLHSGAD---------------IQQ---------VGYG-----GLTALHIATIAGHL 147
+ LL +GA+ +QQ + YG L ALHIA
Sbjct: 160 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 219
Query: 148 EAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLA 207
A VLLQ+ N ++ FTPLHIAA+Y + V +LLL GA VN + + G PLH+A
Sbjct: 220 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 279
Query: 208 SAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVN 267
S +G + + +LL++ G++ + +D + PLH +R GH I + LL +Q N
Sbjct: 280 SRRGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 337
Query: 268 IYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFSETAFHSACTYGKSIDLVKFLL 326
G +P+H+A + + ++Q + +T +++ T H A G + K LL
Sbjct: 338 --GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHH-RVAKVLL 391
Query: 327 DQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLV 369
D+ N + +G T LH AC H+R+++ LL GA ++ V
Sbjct: 392 DKGA-KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 433
Score = 129 bits (323), Expect = 1e-29
Identities = 107/362 (29%), Positives = 164/362 (45%), Gaps = 55/362 (15%)
Query: 39 EKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIR---TLMLKGLRPS 95
+K L LRN V++N +NGL+ LHL K+ H++ L+ K +
Sbjct: 59 DKALDHLRN---------GVDINTCNQNGLNGLHL----ASKEGHVKMVVELLHKEIILE 105
Query: 96 RLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQ 155
T+ G TALH+A E++ L++ GA++ G T L++A HLE LL+
Sbjct: 106 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 165
Query: 156 HGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA------------------------ 191
+GAN N+ FTPL +A GHE V L+ +G
Sbjct: 166 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 225
Query: 192 -----DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 246
+ +V + G PLH+A+ LN+A+LL+ G A VN PLH SR G
Sbjct: 226 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG--ASVNFTPQNGITPLHIASRRG 283
Query: 247 HHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFS 305
+ +V+ LL +++ + TPLH A NG +++ ++ ++ TK +
Sbjct: 284 NVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-- 339
Query: 306 ETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGAD 365
+ H A G +D V+ LL + I+ D T LH A + GH R+ + LLD GA
Sbjct: 340 -SPIHMA-AQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 396
Query: 366 MN 367
N
Sbjct: 397 PN 398
Score = 124 bits (310), Expect = 5e-28
Identities = 79/266 (29%), Positives = 132/266 (49%), Gaps = 7/266 (2%)
Query: 64 TENGLSLLHLCCICGGKKSHIRTLML-KGLRPSRLTRNGFTALHLAVYKDNAELITSLLH 122
T+ G + LH+ G K + L+L + P+ +NG T LH+AV+ +N +++ LL
Sbjct: 566 TKKGFTPLHVAAKYG--KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 623
Query: 123 SGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQV 182
G + G T LHIA +E A LLQ+G + N + TPLH+AA GH ++
Sbjct: 624 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 683
Query: 183 TRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFC 242
LLL A+ N+ + G PLHL + +G + +A +L++ G D A + PLH
Sbjct: 684 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD--ATTRMGYTPLHVA 741
Query: 243 SRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKEN 302
S +G+ +VK+LLQ +V + G +PLH A G ++ +++ + + +
Sbjct: 742 SHYGNIKLVKFLLQHQADV--NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 799
Query: 303 IFSETAFHSACTYGKSIDLVKFLLDQ 328
+ A Y D++K + D+
Sbjct: 800 GTTPLAIAKRLGYISVTDVLKVVTDE 825
Score = 58.9 bits (141), Expect = 2e-08
Identities = 54/210 (25%), Positives = 86/210 (40%), Gaps = 54/210 (25%)
Query: 201 DRPLHLASAKGFL------NIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYL 254
DR +A FL N+ K L + D+N + LH S+ GH +V L
Sbjct: 38 DRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 97
Query: 255 LQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACT 314
L ++ ++ G+T LH+A G+ EV +E++
Sbjct: 98 LHKEIILETTTKK--GNTALHIAALAGQDEVVRELVN----------------------- 132
Query: 315 YGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPS 374
YG N+N Q + G T L+ A H+ +V+FLL+NGA+ N+
Sbjct: 133 YGA--------------NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT---- 174
Query: 375 RSSGEKDEQTCLMWAYEKGHDAIVTLLKHY 404
+D T L A ++GH+ +V L +Y
Sbjct: 175 -----EDGFTPLAVALQQGHENVVAHLINY 199
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 157 bits (398), Expect = 3e-38
Identities = 108/336 (32%), Positives = 166/336 (49%), Gaps = 46/336 (13%)
Query: 63 RTENGLSLLHLCCICGGKKSHIRT---LMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 119
+T++ L+ LH C + H+R L+ G T+NG + +H+A D+ + +
Sbjct: 268 KTKDELTPLH----CAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 120 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 179
LL A+I + LT LH+A GH A VLL GA N + FTPLHIA H
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383
Query: 180 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEG---------------- 223
+V LLLK GA ++ E G PLH+AS G L I K L++ G
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 224 ---------------SKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNI 268
+KA VNA+ +D PLH +R GH ++VK LL+++ P++
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN--ANPNLATT 501
Query: 269 YGDTPLHLACYNGKFEVAKEIIQISGTES-LTKENIFSETAFHSACTYGKSIDLVKFLLD 327
G TPLH+A G E +++ +++ +TK+ T H A YGK + + + LL+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF---TPLHVAAKYGK-VRVAELLLE 557
Query: 328 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNG 363
++ + N G++G T LH A +H ++ +V+ LL G
Sbjct: 558 RDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Score = 157 bits (397), Expect = 4e-38
Identities = 120/373 (32%), Positives = 173/373 (46%), Gaps = 50/373 (13%)
Query: 64 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 123
T + L+ LH+ CG + + L+ KG +P+ NGFT LH+A K++ ++ LL +
Sbjct: 335 TLDHLTPLHVAAHCGHHRV-AKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 124 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 183
GA I V GLT LH+A+ GHL LLQ GA+ N+ + TPLH+AA GH +V
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453
Query: 184 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 243
+ LL+ A VN + PLH A+ G N+ KLL+E + A+ N H PLH +
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE--NNANPNLATTAGHTPLHIAA 511
Query: 244 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENI 303
R GH + V LL+ E + G TPLH+A GK VA+ +++ + +N
Sbjct: 512 REGHVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN- 568
Query: 304 FSETAFHSACTYGKSIDLVKFLL---------------------DQNVINI--------- 333
T H A + ++D+VK LL QN + +
Sbjct: 569 -GLTPLHVA-VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 334 --NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYE 391
N + G T LH A GH +V LL A+ NL G K T L +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---------GNKSGLTPLHLVAQ 677
Query: 392 KGHDAIV-TLLKH 403
+GH + L+KH
Sbjct: 678 EGHVPVADVLIKH 690
Score = 154 bits (388), Expect = 4e-37
Identities = 104/306 (33%), Positives = 156/306 (50%), Gaps = 9/306 (2%)
Query: 59 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 118
++N+ +NG++ LH+ G +R L+ +G + T++ T LH A + +
Sbjct: 231 SVNFTPQNGITPLHIASR-RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
LL GA IQ GL+ +H+A HL+ +LLQ+ A ++ TPLH+AA+ G
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349
Query: 179 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238
H +V ++LL GA N G PLH+A K + + +LL++ G A ++A P
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG--ASIDAVTESGLTP 407
Query: 239 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESL 298
LH S GH IVK LLQ P+V N+ +TPLH+A G EVAK ++Q +
Sbjct: 408 LHVASFMGHLPIVKNLLQRG--ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 299 TKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQF 358
++ +T H A G + ++VK LL+ N N N GHT LH A GH+ V
Sbjct: 466 KAKD--DQTPLHCAARIGHT-NMVKLLLENNA-NPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 359 LLDNGA 364
LL+ A
Sbjct: 522 LLEKEA 527
Score = 141 bits (355), Expect = 3e-33
Identities = 96/341 (28%), Positives = 160/341 (46%), Gaps = 38/341 (11%)
Query: 60 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKG-LRPSRLTRNGFTALHLAVYKDNAELIT 118
+NY T+ + L L + ++L+ P L++ GFT LH+A + +N +
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223
Query: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
LL+ GA + G+T LHIA+ G++ +LL GA + + TPLH AA G
Sbjct: 224 LLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNG 283
Query: 179 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238
H +++ +LL GA + + G P+H+A+ L+ +LL++ ++ D D+ P
Sbjct: 284 HVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--LTP 341
Query: 239 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY----------------------------- 269
LH + GHH + K LL + +N +
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 270 --GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD 327
G TPLH+A + G + K ++Q + +++ N+ ET H A G + ++ K+LL
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPLHMAARAGHT-EVAKYLL- 457
Query: 328 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368
QN +N + +D T LH A GH +V+ LL+N A+ NL
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Score = 140 bits (353), Expect = 5e-33
Identities = 118/407 (28%), Positives = 182/407 (44%), Gaps = 84/407 (20%)
Query: 61 NYRTENGLSLLHLCCICGGKKSHIRT--LMLK-GLRPSRLTRNGFTALHLAVYKDNAELI 117
N R NG + LH+ C KK+H+R L+LK G +T +G T LH+A + + ++
Sbjct: 365 NSRALNGFTPLHIAC----KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 118 TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 177
+LL GA T LH+A AGH E A LLQ+ A VN + TPLH AA
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 178 GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHV 237
GH + +LLL+ A+ N++ G PLH+A+ +G + L+E+ +A +
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK--EASQACMTKKGFT 538
Query: 238 PLHFCSRFGHHDIVKYLLQSD----------------------LEV---------QPHVV 266
PLH +++G + + LL+ D L++ PH
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 267 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL 326
G TPLH+A + EVA+ ++Q G S E++ T H A G + ++V LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGG--SANAESVQGVTPLHLAAQEGHA-EMVALLL 655
Query: 327 DQNV--------------------------------ININHQGRDGHTGLHSACYHGHIR 354
+ + ++ R G+T LH A ++G+I+
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 355 LVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
LV+FLL + AD+N + K + L A ++GH IVTLL
Sbjct: 716 LVKFLLQHQADVN---------AKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 140 bits (352), Expect = 6e-33
Identities = 98/317 (30%), Positives = 157/317 (49%), Gaps = 9/317 (2%)
Query: 56 SKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAE 115
+K +N + ++ + LH C G + ++ L+ P+ T G T LH+A + + E
Sbjct: 459 NKAKVNAKAKDDQTPLH-CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
Query: 116 LITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 175
+ +LL A + G T LH+A G + A++LL+ A+ N TPLH+A
Sbjct: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
Query: 176 YYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 235
++ + + +LLL G + G PLH+A+ + + +A+ L++ G A NA+ +
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQG 635
Query: 236 HVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGT 295
PLH ++ GH ++V LL + ++ N G TPLHL G VA +I+
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSK--QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693
Query: 296 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 355
T T H A YG +I LVKFLL Q+ ++N + + G++ LH A GH +
Sbjct: 694 VDATTR--MGYTPLHVASHYG-NIKLVKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 356 VQFLLDNGADMNLVACD 372
V LL NGA N V+ D
Sbjct: 750 VTLLLKNGASPNEVSSD 766
Score = 136 bits (343), Expect = 7e-32
Identities = 94/274 (34%), Positives = 141/274 (51%), Gaps = 12/274 (4%)
Query: 91 GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAA 150
G+ + +NG LHLA + + +++ LLH ++ G TALHIA +AG E
Sbjct: 35 GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94
Query: 151 DVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAK 210
L+ +GANVN Q FTPL++AA H +V + LL+ GA+ NV+ E G PL +A +
Sbjct: 95 RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154
Query: 211 GFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYG 270
G N+ L+ G+K V LH +R LLQ+D P V++ G
Sbjct: 155 GHENVVAHLINYGTKGKVRLP------ALHIAARNDDTRTAAVLLQND--PNPDVLSKTG 206
Query: 271 DTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNV 330
TPLH+A + VA+ ++ + + T +N T H A G I +V+ LLD+
Sbjct: 207 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASRRGNVI-MVRLLLDRGA 263
Query: 331 ININHQGRDGHTGLHSACYHGHIRLVQFLLDNGA 364
I + +D T LH A +GH+R+ + LLD+GA
Sbjct: 264 -QIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Score = 136 bits (342), Expect = 9e-32
Identities = 102/343 (29%), Positives = 170/343 (49%), Gaps = 40/343 (11%)
Query: 57 KVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAEL 116
++ L T+ G + LH+ + G + +R L+ G + ++ GFT L++A +++ E+
Sbjct: 68 EIILETTTKKGNTALHIAALAG-QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 117 ITSLLHSGAD---------------IQQ---------VGYG-----GLTALHIATIAGHL 147
+ LL +GA+ +QQ + YG L ALHIA
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
Query: 148 EAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLA 207
A VLLQ+ N ++ FTPLHIAA+Y + V +LLL GA VN + + G PLH+A
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246
Query: 208 SAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVN 267
S +G + + +LL++ G++ + +D + PLH +R GH I + LL +Q N
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 268 IYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFSETAFHSACTYGKSIDLVKFLL 326
G +P+H+A + + ++Q + +T +++ T H A G + K LL
Sbjct: 305 --GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHH-RVAKVLL 358
Query: 327 DQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLV 369
D+ N + +G T LH AC H+R+++ LL GA ++ V
Sbjct: 359 DKGA-KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Score = 129 bits (323), Expect = 1e-29
Identities = 107/362 (29%), Positives = 164/362 (45%), Gaps = 55/362 (15%)
Query: 39 EKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIR---TLMLKGLRPS 95
+K L LRN V++N +NGL+ LHL K+ H++ L+ K +
Sbjct: 26 DKALDHLRN---------GVDINTCNQNGLNGLHL----ASKEGHVKMVVELLHKEIILE 72
Query: 96 RLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQ 155
T+ G TALH+A E++ L++ GA++ G T L++A HLE LL+
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 156 HGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA------------------------ 191
+GAN N+ FTPL +A GHE V L+ +G
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192
Query: 192 -----DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 246
+ +V + G PLH+A+ LN+A+LL+ G A VN PLH SR G
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG--ASVNFTPQNGITPLHIASRRG 250
Query: 247 HHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFS 305
+ +V+ LL +++ + TPLH A NG +++ ++ ++ TK +
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-- 306
Query: 306 ETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGAD 365
+ H A G +D V+ LL + I+ D T LH A + GH R+ + LLD GA
Sbjct: 307 -SPIHMA-AQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 366 MN 367
N
Sbjct: 364 PN 365
Score = 124 bits (310), Expect = 5e-28
Identities = 79/266 (29%), Positives = 132/266 (49%), Gaps = 7/266 (2%)
Query: 64 TENGLSLLHLCCICGGKKSHIRTLML-KGLRPSRLTRNGFTALHLAVYKDNAELITSLLH 122
T+ G + LH+ G K + L+L + P+ +NG T LH+AV+ +N +++ LL
Sbjct: 533 TKKGFTPLHVAAKYG--KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 123 SGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQV 182
G + G T LHIA +E A LLQ+G + N + TPLH+AA GH ++
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 183 TRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFC 242
LLL A+ N+ + G PLHL + +G + +A +L++ G D A + PLH
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD--ATTRMGYTPLHVA 708
Query: 243 SRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKEN 302
S +G+ +VK+LLQ +V + G +PLH A G ++ +++ + + +
Sbjct: 709 SHYGNIKLVKFLLQHQADV--NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
Query: 303 IFSETAFHSACTYGKSIDLVKFLLDQ 328
+ A Y D++K + D+
Sbjct: 767 GTTPLAIAKRLGYISVTDVLKVVTDE 792
Score = 58.5 bits (140), Expect = 2e-08
Identities = 49/191 (25%), Positives = 80/191 (41%), Gaps = 48/191 (25%)
Query: 214 NIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTP 273
N+ K L + D+N + LH S+ GH +V LL ++ ++ G+T
Sbjct: 24 NLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK--GNTA 81
Query: 274 LHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVINI 333
LH+A G+ EV +E++ YG N+
Sbjct: 82 LHIAALAGQDEVVRELVN-----------------------YGA--------------NV 104
Query: 334 NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG 393
N Q + G T L+ A H+ +V+FLL+NGA+ N+ +D T L A ++G
Sbjct: 105 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT---------EDGFTPLAVALQQG 155
Query: 394 HDAIVTLLKHY 404
H+ +V L +Y
Sbjct: 156 HENVVAHLINY 166
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 157 bits (398), Expect = 3e-38
Identities = 108/336 (32%), Positives = 166/336 (49%), Gaps = 46/336 (13%)
Query: 63 RTENGLSLLHLCCICGGKKSHIRT---LMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 119
+T++ L+ LH C + H+R L+ G T+NG + +H+A D+ + +
Sbjct: 268 KTKDELTPLH----CAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 120 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 179
LL A+I + LT LH+A GH A VLL GA N + FTPLHIA H
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383
Query: 180 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEG---------------- 223
+V LLLK GA ++ E G PLH+AS G L I K L++ G
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 224 ---------------SKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNI 268
+KA VNA+ +D PLH +R GH ++VK LL+++ P++
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN--ANPNLATT 501
Query: 269 YGDTPLHLACYNGKFEVAKEIIQISGTES-LTKENIFSETAFHSACTYGKSIDLVKFLLD 327
G TPLH+A G E +++ +++ +TK+ T H A YGK + + + LL+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF---TPLHVAAKYGK-VRVAELLLE 557
Query: 328 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNG 363
++ + N G++G T LH A +H ++ +V+ LL G
Sbjct: 558 RDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Score = 157 bits (397), Expect = 4e-38
Identities = 120/373 (32%), Positives = 173/373 (46%), Gaps = 50/373 (13%)
Query: 64 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 123
T + L+ LH+ CG + + L+ KG +P+ NGFT LH+A K++ ++ LL +
Sbjct: 335 TLDHLTPLHVAAHCGHHRV-AKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 124 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 183
GA I V GLT LH+A+ GHL LLQ GA+ N+ + TPLH+AA GH +V
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453
Query: 184 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 243
+ LL+ A VN + PLH A+ G N+ KLL+E + A+ N H PLH +
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE--NNANPNLATTAGHTPLHIAA 511
Query: 244 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENI 303
R GH + V LL+ E + G TPLH+A GK VA+ +++ + +N
Sbjct: 512 REGHVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN- 568
Query: 304 FSETAFHSACTYGKSIDLVKFLL---------------------DQNVINI--------- 333
T H A + ++D+VK LL QN + +
Sbjct: 569 -GLTPLHVA-VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 334 --NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYE 391
N + G T LH A GH +V LL A+ NL G K T L +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---------GNKSGLTPLHLVAQ 677
Query: 392 KGHDAIV-TLLKH 403
+GH + L+KH
Sbjct: 678 EGHVPVADVLIKH 690
Score = 154 bits (388), Expect = 4e-37
Identities = 104/306 (33%), Positives = 156/306 (50%), Gaps = 9/306 (2%)
Query: 59 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 118
++N+ +NG++ LH+ G +R L+ +G + T++ T LH A + +
Sbjct: 231 SVNFTPQNGITPLHIASR-RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
LL GA IQ GL+ +H+A HL+ +LLQ+ A ++ TPLH+AA+ G
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349
Query: 179 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238
H +V ++LL GA N G PLH+A K + + +LL++ G A ++A P
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG--ASIDAVTESGLTP 407
Query: 239 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESL 298
LH S GH IVK LLQ P+V N+ +TPLH+A G EVAK ++Q +
Sbjct: 408 LHVASFMGHLPIVKNLLQRG--ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 299 TKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQF 358
++ +T H A G + ++VK LL+ N N N GHT LH A GH+ V
Sbjct: 466 KAKD--DQTPLHCAARIGHT-NMVKLLLENNA-NPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 359 LLDNGA 364
LL+ A
Sbjct: 522 LLEKEA 527
Score = 141 bits (355), Expect = 3e-33
Identities = 96/341 (28%), Positives = 160/341 (46%), Gaps = 38/341 (11%)
Query: 60 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKG-LRPSRLTRNGFTALHLAVYKDNAELIT 118
+NY T+ + L L + ++L+ P L++ GFT LH+A + +N +
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223
Query: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
LL+ GA + G+T LHIA+ G++ +LL GA + + TPLH AA G
Sbjct: 224 LLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNG 283
Query: 179 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238
H +++ +LL GA + + G P+H+A+ L+ +LL++ ++ D D+ P
Sbjct: 284 HVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--LTP 341
Query: 239 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY----------------------------- 269
LH + GHH + K LL + +N +
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 270 --GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD 327
G TPLH+A + G + K ++Q + +++ N+ ET H A G + ++ K+LL
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPLHMAARAGHT-EVAKYLL- 457
Query: 328 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368
QN +N + +D T LH A GH +V+ LL+N A+ NL
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Score = 140 bits (353), Expect = 5e-33
Identities = 118/407 (28%), Positives = 182/407 (44%), Gaps = 84/407 (20%)
Query: 61 NYRTENGLSLLHLCCICGGKKSHIRT--LMLK-GLRPSRLTRNGFTALHLAVYKDNAELI 117
N R NG + LH+ C KK+H+R L+LK G +T +G T LH+A + + ++
Sbjct: 365 NSRALNGFTPLHIAC----KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 118 TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 177
+LL GA T LH+A AGH E A LLQ+ A VN + TPLH AA
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 178 GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHV 237
GH + +LLL+ A+ N++ G PLH+A+ +G + L+E+ +A +
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK--EASQACMTKKGFT 538
Query: 238 PLHFCSRFGHHDIVKYLLQSD----------------------LEV---------QPHVV 266
PLH +++G + + LL+ D L++ PH
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 267 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL 326
G TPLH+A + EVA+ ++Q G S E++ T H A G + ++V LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGG--SANAESVQGVTPLHLAAQEGHA-EMVALLL 655
Query: 327 DQNV--------------------------------ININHQGRDGHTGLHSACYHGHIR 354
+ + ++ R G+T LH A ++G+I+
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 355 LVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
LV+FLL + AD+N + K + L A ++GH IVTLL
Sbjct: 716 LVKFLLQHQADVN---------AKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 140 bits (352), Expect = 6e-33
Identities = 98/317 (30%), Positives = 157/317 (49%), Gaps = 9/317 (2%)
Query: 56 SKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAE 115
+K +N + ++ + LH C G + ++ L+ P+ T G T LH+A + + E
Sbjct: 459 NKAKVNAKAKDDQTPLH-CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
Query: 116 LITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 175
+ +LL A + G T LH+A G + A++LL+ A+ N TPLH+A
Sbjct: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
Query: 176 YYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 235
++ + + +LLL G + G PLH+A+ + + +A+ L++ G A NA+ +
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQG 635
Query: 236 HVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGT 295
PLH ++ GH ++V LL + ++ N G TPLHL G VA +I+
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSK--QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693
Query: 296 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 355
T T H A YG +I LVKFLL Q+ ++N + + G++ LH A GH +
Sbjct: 694 VDATTR--MGYTPLHVASHYG-NIKLVKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 356 VQFLLDNGADMNLVACD 372
V LL NGA N V+ D
Sbjct: 750 VTLLLKNGASPNEVSSD 766
Score = 136 bits (343), Expect = 7e-32
Identities = 94/274 (34%), Positives = 141/274 (51%), Gaps = 12/274 (4%)
Query: 91 GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAA 150
G+ + +NG LHLA + + +++ LLH ++ G TALHIA +AG E
Sbjct: 35 GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94
Query: 151 DVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAK 210
L+ +GANVN Q FTPL++AA H +V + LL+ GA+ NV+ E G PL +A +
Sbjct: 95 RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154
Query: 211 GFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYG 270
G N+ L+ G+K V LH +R LLQ+D P V++ G
Sbjct: 155 GHENVVAHLINYGTKGKVRLP------ALHIAARNDDTRTAAVLLQND--PNPDVLSKTG 206
Query: 271 DTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNV 330
TPLH+A + VA+ ++ + + T +N T H A G I +V+ LLD+
Sbjct: 207 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASRRGNVI-MVRLLLDRGA 263
Query: 331 ININHQGRDGHTGLHSACYHGHIRLVQFLLDNGA 364
I + +D T LH A +GH+R+ + LLD+GA
Sbjct: 264 -QIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Score = 136 bits (342), Expect = 9e-32
Identities = 102/343 (29%), Positives = 170/343 (49%), Gaps = 40/343 (11%)
Query: 57 KVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAEL 116
++ L T+ G + LH+ + G + +R L+ G + ++ GFT L++A +++ E+
Sbjct: 68 EIILETTTKKGNTALHIAALAG-QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 117 ITSLLHSGAD---------------IQQ---------VGYG-----GLTALHIATIAGHL 147
+ LL +GA+ +QQ + YG L ALHIA
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
Query: 148 EAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLA 207
A VLLQ+ N ++ FTPLHIAA+Y + V +LLL GA VN + + G PLH+A
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246
Query: 208 SAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVN 267
S +G + + +LL++ G++ + +D + PLH +R GH I + LL +Q N
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 268 IYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFSETAFHSACTYGKSIDLVKFLL 326
G +P+H+A + + ++Q + +T +++ T H A G + K LL
Sbjct: 305 --GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHH-RVAKVLL 358
Query: 327 DQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLV 369
D+ N + +G T LH AC H+R+++ LL GA ++ V
Sbjct: 359 DKGA-KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Score = 129 bits (323), Expect = 1e-29
Identities = 107/362 (29%), Positives = 164/362 (45%), Gaps = 55/362 (15%)
Query: 39 EKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIR---TLMLKGLRPS 95
+K L LRN V++N +NGL+ LHL K+ H++ L+ K +
Sbjct: 26 DKALDHLRN---------GVDINTCNQNGLNGLHL----ASKEGHVKMVVELLHKEIILE 72
Query: 96 RLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQ 155
T+ G TALH+A E++ L++ GA++ G T L++A HLE LL+
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 156 HGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA------------------------ 191
+GAN N+ FTPL +A GHE V L+ +G
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192
Query: 192 -----DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 246
+ +V + G PLH+A+ LN+A+LL+ G A VN PLH SR G
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG--ASVNFTPQNGITPLHIASRRG 250
Query: 247 HHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFS 305
+ +V+ LL +++ + TPLH A NG +++ ++ ++ TK +
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-- 306
Query: 306 ETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGAD 365
+ H A G +D V+ LL + I+ D T LH A + GH R+ + LLD GA
Sbjct: 307 -SPIHMA-AQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 366 MN 367
N
Sbjct: 364 PN 365
Score = 124 bits (310), Expect = 5e-28
Identities = 79/266 (29%), Positives = 132/266 (49%), Gaps = 7/266 (2%)
Query: 64 TENGLSLLHLCCICGGKKSHIRTLML-KGLRPSRLTRNGFTALHLAVYKDNAELITSLLH 122
T+ G + LH+ G K + L+L + P+ +NG T LH+AV+ +N +++ LL
Sbjct: 533 TKKGFTPLHVAAKYG--KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 123 SGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQV 182
G + G T LHIA +E A LLQ+G + N + TPLH+AA GH ++
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 183 TRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFC 242
LLL A+ N+ + G PLHL + +G + +A +L++ G D A + PLH
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD--ATTRMGYTPLHVA 708
Query: 243 SRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKEN 302
S +G+ +VK+LLQ +V + G +PLH A G ++ +++ + + +
Sbjct: 709 SHYGNIKLVKFLLQHQADV--NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
Query: 303 IFSETAFHSACTYGKSIDLVKFLLDQ 328
+ A Y D++K + D+
Sbjct: 767 GTTPLAIAKRLGYISVTDVLKVVTDE 792
Score = 58.5 bits (140), Expect = 2e-08
Identities = 49/191 (25%), Positives = 80/191 (41%), Gaps = 48/191 (25%)
Query: 214 NIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTP 273
N+ K L + D+N + LH S+ GH +V LL ++ ++ G+T
Sbjct: 24 NLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK--GNTA 81
Query: 274 LHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVINI 333
LH+A G+ EV +E++ YG N+
Sbjct: 82 LHIAALAGQDEVVRELVN-----------------------YGA--------------NV 104
Query: 334 NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG 393
N Q + G T L+ A H+ +V+FLL+NGA+ N+ +D T L A ++G
Sbjct: 105 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT---------EDGFTPLAVALQQG 155
Query: 394 HDAIVTLLKHY 404
H+ +V L +Y
Sbjct: 156 HENVVAHLINY 166
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 157 bits (398), Expect = 3e-38
Identities = 108/336 (32%), Positives = 166/336 (49%), Gaps = 46/336 (13%)
Query: 63 RTENGLSLLHLCCICGGKKSHIRT---LMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 119
+T++ L+ LH C + H+R L+ G T+NG + +H+A D+ + +
Sbjct: 268 KTKDELTPLH----CAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 120 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 179
LL A+I + LT LH+A GH A VLL GA N + FTPLHIA H
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383
Query: 180 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEG---------------- 223
+V LLLK GA ++ E G PLH+AS G L I K L++ G
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 224 ---------------SKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNI 268
+KA VNA+ +D PLH +R GH ++VK LL+++ P++
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN--ANPNLATT 501
Query: 269 YGDTPLHLACYNGKFEVAKEIIQISGTES-LTKENIFSETAFHSACTYGKSIDLVKFLLD 327
G TPLH+A G E +++ +++ +TK+ T H A YGK + + + LL+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF---TPLHVAAKYGK-VRVAELLLE 557
Query: 328 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNG 363
++ + N G++G T LH A +H ++ +V+ LL G
Sbjct: 558 RDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Score = 157 bits (397), Expect = 4e-38
Identities = 120/373 (32%), Positives = 173/373 (46%), Gaps = 50/373 (13%)
Query: 64 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 123
T + L+ LH+ CG + + L+ KG +P+ NGFT LH+A K++ ++ LL +
Sbjct: 335 TLDHLTPLHVAAHCGHHRV-AKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 124 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 183
GA I V GLT LH+A+ GHL LLQ GA+ N+ + TPLH+AA GH +V
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453
Query: 184 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 243
+ LL+ A VN + PLH A+ G N+ KLL+E + A+ N H PLH +
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE--NNANPNLATTAGHTPLHIAA 511
Query: 244 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENI 303
R GH + V LL+ E + G TPLH+A GK VA+ +++ + +N
Sbjct: 512 REGHVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN- 568
Query: 304 FSETAFHSACTYGKSIDLVKFLL---------------------DQNVINI--------- 333
T H A + ++D+VK LL QN + +
Sbjct: 569 -GLTPLHVA-VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 334 --NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYE 391
N + G T LH A GH +V LL A+ NL G K T L +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---------GNKSGLTPLHLVAQ 677
Query: 392 KGHDAIV-TLLKH 403
+GH + L+KH
Sbjct: 678 EGHVPVADVLIKH 690
Score = 154 bits (388), Expect = 4e-37
Identities = 104/306 (33%), Positives = 156/306 (50%), Gaps = 9/306 (2%)
Query: 59 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 118
++N+ +NG++ LH+ G +R L+ +G + T++ T LH A + +
Sbjct: 231 SVNFTPQNGITPLHIASR-RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
LL GA IQ GL+ +H+A HL+ +LLQ+ A ++ TPLH+AA+ G
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349
Query: 179 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238
H +V ++LL GA N G PLH+A K + + +LL++ G A ++A P
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG--ASIDAVTESGLTP 407
Query: 239 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESL 298
LH S GH IVK LLQ P+V N+ +TPLH+A G EVAK ++Q +
Sbjct: 408 LHVASFMGHLPIVKNLLQRG--ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 299 TKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQF 358
++ +T H A G + ++VK LL+ N N N GHT LH A GH+ V
Sbjct: 466 KAKD--DQTPLHCAARIGHT-NMVKLLLENNA-NPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 359 LLDNGA 364
LL+ A
Sbjct: 522 LLEKEA 527
Score = 141 bits (355), Expect = 3e-33
Identities = 96/341 (28%), Positives = 160/341 (46%), Gaps = 38/341 (11%)
Query: 60 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKG-LRPSRLTRNGFTALHLAVYKDNAELIT 118
+NY T+ + L L + ++L+ P L++ GFT LH+A + +N +
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223
Query: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
LL+ GA + G+T LHIA+ G++ +LL GA + + TPLH AA G
Sbjct: 224 LLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNG 283
Query: 179 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238
H +++ +LL GA + + G P+H+A+ L+ +LL++ ++ D D+ P
Sbjct: 284 HVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--LTP 341
Query: 239 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY----------------------------- 269
LH + GHH + K LL + +N +
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 270 --GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD 327
G TPLH+A + G + K ++Q + +++ N+ ET H A G + ++ K+LL
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPLHMAARAGHT-EVAKYLL- 457
Query: 328 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368
QN +N + +D T LH A GH +V+ LL+N A+ NL
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Score = 140 bits (353), Expect = 5e-33
Identities = 118/407 (28%), Positives = 182/407 (44%), Gaps = 84/407 (20%)
Query: 61 NYRTENGLSLLHLCCICGGKKSHIRT--LMLK-GLRPSRLTRNGFTALHLAVYKDNAELI 117
N R NG + LH+ C KK+H+R L+LK G +T +G T LH+A + + ++
Sbjct: 365 NSRALNGFTPLHIAC----KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 118 TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 177
+LL GA T LH+A AGH E A LLQ+ A VN + TPLH AA
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 178 GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHV 237
GH + +LLL+ A+ N++ G PLH+A+ +G + L+E+ +A +
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK--EASQACMTKKGFT 538
Query: 238 PLHFCSRFGHHDIVKYLLQSD----------------------LEV---------QPHVV 266
PLH +++G + + LL+ D L++ PH
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 267 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL 326
G TPLH+A + EVA+ ++Q G S E++ T H A G + ++V LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGG--SANAESVQGVTPLHLAAQEGHA-EMVALLL 655
Query: 327 DQNV--------------------------------ININHQGRDGHTGLHSACYHGHIR 354
+ + ++ R G+T LH A ++G+I+
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 355 LVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
LV+FLL + AD+N + K + L A ++GH IVTLL
Sbjct: 716 LVKFLLQHQADVN---------AKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 140 bits (352), Expect = 6e-33
Identities = 98/317 (30%), Positives = 157/317 (49%), Gaps = 9/317 (2%)
Query: 56 SKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAE 115
+K +N + ++ + LH C G + ++ L+ P+ T G T LH+A + + E
Sbjct: 459 NKAKVNAKAKDDQTPLH-CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
Query: 116 LITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 175
+ +LL A + G T LH+A G + A++LL+ A+ N TPLH+A
Sbjct: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
Query: 176 YYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 235
++ + + +LLL G + G PLH+A+ + + +A+ L++ G A NA+ +
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQG 635
Query: 236 HVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGT 295
PLH ++ GH ++V LL + ++ N G TPLHL G VA +I+
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSK--QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693
Query: 296 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 355
T T H A YG +I LVKFLL Q+ ++N + + G++ LH A GH +
Sbjct: 694 VDATTR--MGYTPLHVASHYG-NIKLVKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 356 VQFLLDNGADMNLVACD 372
V LL NGA N V+ D
Sbjct: 750 VTLLLKNGASPNEVSSD 766
Score = 136 bits (343), Expect = 7e-32
Identities = 94/274 (34%), Positives = 141/274 (51%), Gaps = 12/274 (4%)
Query: 91 GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAA 150
G+ + +NG LHLA + + +++ LLH ++ G TALHIA +AG E
Sbjct: 35 GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94
Query: 151 DVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAK 210
L+ +GANVN Q FTPL++AA H +V + LL+ GA+ NV+ E G PL +A +
Sbjct: 95 RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154
Query: 211 GFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYG 270
G N+ L+ G+K V LH +R LLQ+D P V++ G
Sbjct: 155 GHENVVAHLINYGTKGKVRLP------ALHIAARNDDTRTAAVLLQND--PNPDVLSKTG 206
Query: 271 DTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNV 330
TPLH+A + VA+ ++ + + T +N T H A G I +V+ LLD+
Sbjct: 207 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASRRGNVI-MVRLLLDRGA 263
Query: 331 ININHQGRDGHTGLHSACYHGHIRLVQFLLDNGA 364
I + +D T LH A +GH+R+ + LLD+GA
Sbjct: 264 -QIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Score = 136 bits (342), Expect = 9e-32
Identities = 102/343 (29%), Positives = 170/343 (49%), Gaps = 40/343 (11%)
Query: 57 KVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAEL 116
++ L T+ G + LH+ + G + +R L+ G + ++ GFT L++A +++ E+
Sbjct: 68 EIILETTTKKGNTALHIAALAG-QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 117 ITSLLHSGAD---------------IQQ---------VGYG-----GLTALHIATIAGHL 147
+ LL +GA+ +QQ + YG L ALHIA
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
Query: 148 EAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLA 207
A VLLQ+ N ++ FTPLHIAA+Y + V +LLL GA VN + + G PLH+A
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246
Query: 208 SAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVN 267
S +G + + +LL++ G++ + +D + PLH +R GH I + LL +Q N
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 268 IYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFSETAFHSACTYGKSIDLVKFLL 326
G +P+H+A + + ++Q + +T +++ T H A G + K LL
Sbjct: 305 --GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHH-RVAKVLL 358
Query: 327 DQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLV 369
D+ N + +G T LH AC H+R+++ LL GA ++ V
Sbjct: 359 DKGA-KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Score = 129 bits (323), Expect = 1e-29
Identities = 107/362 (29%), Positives = 164/362 (45%), Gaps = 55/362 (15%)
Query: 39 EKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIR---TLMLKGLRPS 95
+K L LRN V++N +NGL+ LHL K+ H++ L+ K +
Sbjct: 26 DKALDHLRN---------GVDINTCNQNGLNGLHL----ASKEGHVKMVVELLHKEIILE 72
Query: 96 RLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQ 155
T+ G TALH+A E++ L++ GA++ G T L++A HLE LL+
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 156 HGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA------------------------ 191
+GAN N+ FTPL +A GHE V L+ +G
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192
Query: 192 -----DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 246
+ +V + G PLH+A+ LN+A+LL+ G A VN PLH SR G
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG--ASVNFTPQNGITPLHIASRRG 250
Query: 247 HHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFS 305
+ +V+ LL +++ + TPLH A NG +++ ++ ++ TK +
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-- 306
Query: 306 ETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGAD 365
+ H A G +D V+ LL + I+ D T LH A + GH R+ + LLD GA
Sbjct: 307 -SPIHMA-AQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 366 MN 367
N
Sbjct: 364 PN 365
Score = 124 bits (310), Expect = 5e-28
Identities = 79/266 (29%), Positives = 132/266 (49%), Gaps = 7/266 (2%)
Query: 64 TENGLSLLHLCCICGGKKSHIRTLML-KGLRPSRLTRNGFTALHLAVYKDNAELITSLLH 122
T+ G + LH+ G K + L+L + P+ +NG T LH+AV+ +N +++ LL
Sbjct: 533 TKKGFTPLHVAAKYG--KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 123 SGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQV 182
G + G T LHIA +E A LLQ+G + N + TPLH+AA GH ++
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 183 TRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFC 242
LLL A+ N+ + G PLHL + +G + +A +L++ G D A + PLH
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD--ATTRMGYTPLHVA 708
Query: 243 SRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKEN 302
S +G+ +VK+LLQ +V + G +PLH A G ++ +++ + + +
Sbjct: 709 SHYGNIKLVKFLLQHQADV--NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
Query: 303 IFSETAFHSACTYGKSIDLVKFLLDQ 328
+ A Y D++K + D+
Sbjct: 767 GTTPLAIAKRLGYISVTDVLKVVTDE 792
Score = 58.5 bits (140), Expect = 2e-08
Identities = 49/191 (25%), Positives = 80/191 (41%), Gaps = 48/191 (25%)
Query: 214 NIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTP 273
N+ K L + D+N + LH S+ GH +V LL ++ ++ G+T
Sbjct: 24 NLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK--GNTA 81
Query: 274 LHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVINI 333
LH+A G+ EV +E++ YG N+
Sbjct: 82 LHIAALAGQDEVVRELVN-----------------------YGA--------------NV 104
Query: 334 NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG 393
N Q + G T L+ A H+ +V+FLL+NGA+ N+ +D T L A ++G
Sbjct: 105 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT---------EDGFTPLAVALQQG 155
Query: 394 HDAIVTLLKHY 404
H+ +V L +Y
Sbjct: 156 HENVVAHLINY 166
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 157 bits (398), Expect = 3e-38
Identities = 108/336 (32%), Positives = 166/336 (49%), Gaps = 46/336 (13%)
Query: 63 RTENGLSLLHLCCICGGKKSHIRT---LMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 119
+T++ L+ LH C + H+R L+ G T+NG + +H+A D+ + +
Sbjct: 268 KTKDELTPLH----CAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 120 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 179
LL A+I + LT LH+A GH A VLL GA N + FTPLHIA H
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383
Query: 180 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEG---------------- 223
+V LLLK GA ++ E G PLH+AS G L I K L++ G
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 224 ---------------SKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNI 268
+KA VNA+ +D PLH +R GH ++VK LL+++ P++
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN--ANPNLATT 501
Query: 269 YGDTPLHLACYNGKFEVAKEIIQISGTES-LTKENIFSETAFHSACTYGKSIDLVKFLLD 327
G TPLH+A G E +++ +++ +TK+ T H A YGK + + + LL+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF---TPLHVAAKYGK-VRVAELLLE 557
Query: 328 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNG 363
++ + N G++G T LH A +H ++ +V+ LL G
Sbjct: 558 RDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Score = 157 bits (397), Expect = 4e-38
Identities = 120/373 (32%), Positives = 173/373 (46%), Gaps = 50/373 (13%)
Query: 64 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 123
T + L+ LH+ CG + + L+ KG +P+ NGFT LH+A K++ ++ LL +
Sbjct: 335 TLDHLTPLHVAAHCGHHRV-AKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 124 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 183
GA I V GLT LH+A+ GHL LLQ GA+ N+ + TPLH+AA GH +V
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453
Query: 184 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 243
+ LL+ A VN + PLH A+ G N+ KLL+E + A+ N H PLH +
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE--NNANPNLATTAGHTPLHIAA 511
Query: 244 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENI 303
R GH + V LL+ E + G TPLH+A GK VA+ +++ + +N
Sbjct: 512 REGHVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN- 568
Query: 304 FSETAFHSACTYGKSIDLVKFLL---------------------DQNVINI--------- 333
T H A + ++D+VK LL QN + +
Sbjct: 569 -GLTPLHVA-VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 334 --NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYE 391
N + G T LH A GH +V LL A+ NL G K T L +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---------GNKSGLTPLHLVAQ 677
Query: 392 KGHDAIV-TLLKH 403
+GH + L+KH
Sbjct: 678 EGHVPVADVLIKH 690
Score = 154 bits (388), Expect = 4e-37
Identities = 104/306 (33%), Positives = 156/306 (50%), Gaps = 9/306 (2%)
Query: 59 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 118
++N+ +NG++ LH+ G +R L+ +G + T++ T LH A + +
Sbjct: 231 SVNFTPQNGITPLHIASR-RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
LL GA IQ GL+ +H+A HL+ +LLQ+ A ++ TPLH+AA+ G
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349
Query: 179 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238
H +V ++LL GA N G PLH+A K + + +LL++ G A ++A P
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG--ASIDAVTESGLTP 407
Query: 239 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESL 298
LH S GH IVK LLQ P+V N+ +TPLH+A G EVAK ++Q +
Sbjct: 408 LHVASFMGHLPIVKNLLQRG--ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 299 TKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQF 358
++ +T H A G + ++VK LL+ N N N GHT LH A GH+ V
Sbjct: 466 KAKD--DQTPLHCAARIGHT-NMVKLLLENNA-NPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 359 LLDNGA 364
LL+ A
Sbjct: 522 LLEKEA 527
Score = 141 bits (355), Expect = 3e-33
Identities = 96/341 (28%), Positives = 160/341 (46%), Gaps = 38/341 (11%)
Query: 60 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKG-LRPSRLTRNGFTALHLAVYKDNAELIT 118
+NY T+ + L L + ++L+ P L++ GFT LH+A + +N +
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223
Query: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
LL+ GA + G+T LHIA+ G++ +LL GA + + TPLH AA G
Sbjct: 224 LLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNG 283
Query: 179 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238
H +++ +LL GA + + G P+H+A+ L+ +LL++ ++ D D+ P
Sbjct: 284 HVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--LTP 341
Query: 239 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY----------------------------- 269
LH + GHH + K LL + +N +
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 270 --GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD 327
G TPLH+A + G + K ++Q + +++ N+ ET H A G + ++ K+LL
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPLHMAARAGHT-EVAKYLL- 457
Query: 328 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368
QN +N + +D T LH A GH +V+ LL+N A+ NL
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Score = 140 bits (353), Expect = 5e-33
Identities = 118/407 (28%), Positives = 182/407 (44%), Gaps = 84/407 (20%)
Query: 61 NYRTENGLSLLHLCCICGGKKSHIRT--LMLK-GLRPSRLTRNGFTALHLAVYKDNAELI 117
N R NG + LH+ C KK+H+R L+LK G +T +G T LH+A + + ++
Sbjct: 365 NSRALNGFTPLHIAC----KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 118 TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 177
+LL GA T LH+A AGH E A LLQ+ A VN + TPLH AA
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 178 GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHV 237
GH + +LLL+ A+ N++ G PLH+A+ +G + L+E+ +A +
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK--EASQACMTKKGFT 538
Query: 238 PLHFCSRFGHHDIVKYLLQSD----------------------LEV---------QPHVV 266
PLH +++G + + LL+ D L++ PH
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 267 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL 326
G TPLH+A + EVA+ ++Q G S E++ T H A G + ++V LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGG--SANAESVQGVTPLHLAAQEGHA-EMVALLL 655
Query: 327 DQNV--------------------------------ININHQGRDGHTGLHSACYHGHIR 354
+ + ++ R G+T LH A ++G+I+
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 355 LVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
LV+FLL + AD+N + K + L A ++GH IVTLL
Sbjct: 716 LVKFLLQHQADVN---------AKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 140 bits (352), Expect = 6e-33
Identities = 98/317 (30%), Positives = 157/317 (49%), Gaps = 9/317 (2%)
Query: 56 SKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAE 115
+K +N + ++ + LH C G + ++ L+ P+ T G T LH+A + + E
Sbjct: 459 NKAKVNAKAKDDQTPLH-CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
Query: 116 LITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 175
+ +LL A + G T LH+A G + A++LL+ A+ N TPLH+A
Sbjct: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
Query: 176 YYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 235
++ + + +LLL G + G PLH+A+ + + +A+ L++ G A NA+ +
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQG 635
Query: 236 HVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGT 295
PLH ++ GH ++V LL + ++ N G TPLHL G VA +I+
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSK--QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693
Query: 296 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 355
T T H A YG +I LVKFLL Q+ ++N + + G++ LH A GH +
Sbjct: 694 VDATTR--MGYTPLHVASHYG-NIKLVKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 356 VQFLLDNGADMNLVACD 372
V LL NGA N V+ D
Sbjct: 750 VTLLLKNGASPNEVSSD 766
Score = 136 bits (343), Expect = 7e-32
Identities = 94/274 (34%), Positives = 141/274 (51%), Gaps = 12/274 (4%)
Query: 91 GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAA 150
G+ + +NG LHLA + + +++ LLH ++ G TALHIA +AG E
Sbjct: 35 GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94
Query: 151 DVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAK 210
L+ +GANVN Q FTPL++AA H +V + LL+ GA+ NV+ E G PL +A +
Sbjct: 95 RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154
Query: 211 GFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYG 270
G N+ L+ G+K V LH +R LLQ+D P V++ G
Sbjct: 155 GHENVVAHLINYGTKGKVRLP------ALHIAARNDDTRTAAVLLQND--PNPDVLSKTG 206
Query: 271 DTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNV 330
TPLH+A + VA+ ++ + + T +N T H A G I +V+ LLD+
Sbjct: 207 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASRRGNVI-MVRLLLDRGA 263
Query: 331 ININHQGRDGHTGLHSACYHGHIRLVQFLLDNGA 364
I + +D T LH A +GH+R+ + LLD+GA
Sbjct: 264 -QIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Score = 136 bits (342), Expect = 9e-32
Identities = 102/343 (29%), Positives = 170/343 (49%), Gaps = 40/343 (11%)
Query: 57 KVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAEL 116
++ L T+ G + LH+ + G + +R L+ G + ++ GFT L++A +++ E+
Sbjct: 68 EIILETTTKKGNTALHIAALAG-QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 117 ITSLLHSGAD---------------IQQ---------VGYG-----GLTALHIATIAGHL 147
+ LL +GA+ +QQ + YG L ALHIA
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
Query: 148 EAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLA 207
A VLLQ+ N ++ FTPLHIAA+Y + V +LLL GA VN + + G PLH+A
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246
Query: 208 SAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVN 267
S +G + + +LL++ G++ + +D + PLH +R GH I + LL +Q N
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 268 IYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFSETAFHSACTYGKSIDLVKFLL 326
G +P+H+A + + ++Q + +T +++ T H A G + K LL
Sbjct: 305 --GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHH-RVAKVLL 358
Query: 327 DQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLV 369
D+ N + +G T LH AC H+R+++ LL GA ++ V
Sbjct: 359 DKGA-KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Score = 129 bits (323), Expect = 1e-29
Identities = 107/362 (29%), Positives = 164/362 (45%), Gaps = 55/362 (15%)
Query: 39 EKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIR---TLMLKGLRPS 95
+K L LRN V++N +NGL+ LHL K+ H++ L+ K +
Sbjct: 26 DKALDHLRN---------GVDINTCNQNGLNGLHL----ASKEGHVKMVVELLHKEIILE 72
Query: 96 RLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQ 155
T+ G TALH+A E++ L++ GA++ G T L++A HLE LL+
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 156 HGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA------------------------ 191
+GAN N+ FTPL +A GHE V L+ +G
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192
Query: 192 -----DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 246
+ +V + G PLH+A+ LN+A+LL+ G A VN PLH SR G
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG--ASVNFTPQNGITPLHIASRRG 250
Query: 247 HHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFS 305
+ +V+ LL +++ + TPLH A NG +++ ++ ++ TK +
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-- 306
Query: 306 ETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGAD 365
+ H A G +D V+ LL + I+ D T LH A + GH R+ + LLD GA
Sbjct: 307 -SPIHMA-AQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 366 MN 367
N
Sbjct: 364 PN 365
Score = 124 bits (310), Expect = 5e-28
Identities = 79/266 (29%), Positives = 132/266 (49%), Gaps = 7/266 (2%)
Query: 64 TENGLSLLHLCCICGGKKSHIRTLML-KGLRPSRLTRNGFTALHLAVYKDNAELITSLLH 122
T+ G + LH+ G K + L+L + P+ +NG T LH+AV+ +N +++ LL
Sbjct: 533 TKKGFTPLHVAAKYG--KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 123 SGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQV 182
G + G T LHIA +E A LLQ+G + N + TPLH+AA GH ++
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 183 TRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFC 242
LLL A+ N+ + G PLHL + +G + +A +L++ G D A + PLH
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD--ATTRMGYTPLHVA 708
Query: 243 SRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKEN 302
S +G+ +VK+LLQ +V + G +PLH A G ++ +++ + + +
Sbjct: 709 SHYGNIKLVKFLLQHQADV--NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
Query: 303 IFSETAFHSACTYGKSIDLVKFLLDQ 328
+ A Y D++K + D+
Sbjct: 767 GTTPLAIAKRLGYISVTDVLKVVTDE 792
Score = 58.5 bits (140), Expect = 2e-08
Identities = 49/191 (25%), Positives = 80/191 (41%), Gaps = 48/191 (25%)
Query: 214 NIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTP 273
N+ K L + D+N + LH S+ GH +V LL ++ ++ G+T
Sbjct: 24 NLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK--GNTA 81
Query: 274 LHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVINI 333
LH+A G+ EV +E++ YG N+
Sbjct: 82 LHIAALAGQDEVVRELVN-----------------------YGA--------------NV 104
Query: 334 NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG 393
N Q + G T L+ A H+ +V+FLL+NGA+ N+ +D T L A ++G
Sbjct: 105 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT---------EDGFTPLAVALQQG 155
Query: 394 HDAIVTLLKHY 404
H+ +V L +Y
Sbjct: 156 HENVVAHLINY 166
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 157 bits (396), Expect = 5e-38
Identities = 115/376 (30%), Positives = 172/376 (45%), Gaps = 47/376 (12%)
Query: 60 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 119
++ +T +GL+ LH C G + L+ +G T+NG + LH+A D+ E +
Sbjct: 271 IDAKTRDGLTPLH-CAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 329
Query: 120 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 179
LL A + V LTALH+A GH +LL AN N + FTPLHIA
Sbjct: 330 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 389
Query: 180 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD------------ 227
+V LL+K+GA + E G P+H+A+ G LNI LL++ G+ D
Sbjct: 390 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 449
Query: 228 -------------------VNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNI 268
V+A+ E+ PLH SR G +IV+ LLQ P
Sbjct: 450 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH--MAHPDAATT 507
Query: 269 YGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQ 328
G TPLH++ G+ +VA +++ SL + F T H A YG S+D+ K LL +
Sbjct: 508 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF--TPLHVAAKYG-SLDVAKLLLQR 564
Query: 329 NVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMW 388
+ G++G T LH A ++ + ++ LL+ GA + A K+ T L
Sbjct: 565 RAA-ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA---------KNGYTPLHI 614
Query: 389 AYEKGHDAIVTLLKHY 404
A +K I + L +Y
Sbjct: 615 AAKKNQMQIASTLLNY 630
Score = 148 bits (374), Expect = 2e-35
Identities = 104/324 (32%), Positives = 158/324 (48%), Gaps = 17/324 (5%)
Query: 79 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 138
GK ++ L+ P T NG+T LH++ + ++ + LL +GA G T L
Sbjct: 487 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 546
Query: 139 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGE 198
H+A G L+ A +LLQ A + TPLH+AA+Y +++V LLL+ GA + + +
Sbjct: 547 HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK 606
Query: 199 VGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSD 258
G PLH+A+ K + IA L+ G A+ N + PLH S+ GH D+V LL
Sbjct: 607 NGYTPLHIAAKKNQMQIASTLLNYG--AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 664
Query: 259 LEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKS 318
+ H+ G T LHLA K VA +I+ G + + T AC YG +
Sbjct: 665 ANI--HMSTKSGLTSLHLAAQEDKVNVA-DILTKHGADQDAHTKL-GYTPLIVACHYG-N 719
Query: 319 IDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSG 378
+ +V FLL Q N+N + ++G+T LH A GH ++ LL +GA N + +
Sbjct: 720 VKMVNFLLKQGA-NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGN---- 774
Query: 379 EKDEQTCLMWAYEKGHDAIVTLLK 402
T L A G+ ++V LK
Sbjct: 775 -----TALAIAKRLGYISVVDTLK 793
Score = 139 bits (349), Expect = 1e-32
Identities = 113/420 (26%), Positives = 188/420 (44%), Gaps = 89/420 (21%)
Query: 57 KVNLNYRTENGLSLLHLCCICGGKKSHIRTLML---KGLRPSRLTRNGFTALHLAVYKDN 113
+ N N R NG + LH+ C KK+ I+ + L G +T +G T +H+A + +
Sbjct: 367 RANPNARALNGFTPLHIAC----KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGH 422
Query: 114 AELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHI 173
++ LL +GA G TALH+A AG +E LL++GA V+ + TPLHI
Sbjct: 423 LNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 482
Query: 174 AAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDN 233
A+ G ++ +LLL+ A + + G PLH+++ +G +++A +L+E G+ + +
Sbjct: 483 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK-- 540
Query: 234 EDHVPLHFCSRFGHHDIVKYLLQS-------------------------------DLEVQ 262
+ PLH +++G D+ K LLQ +
Sbjct: 541 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 600
Query: 263 PHVVNIYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFSETAFHSACTYGKSIDL 321
PH G TPLH+A + ++A ++ T +TK+ + T H A G + D+
Sbjct: 601 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV---TPLHLASQEGHT-DM 656
Query: 322 VKFLLDQNVININHQGRDGHTGLH---------------------------------SAC 348
V LLD+ NI+ + G T LH AC
Sbjct: 657 VTLLLDKGA-NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVAC 715
Query: 349 YHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIV-TLLKHYKRP 407
++G++++V FLL GA++N + K+ T L A ++GH I+ LL+H +P
Sbjct: 716 HYGNVKMVNFLLKQGANVN---------AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 766
Score = 137 bits (344), Expect = 5e-32
Identities = 101/324 (31%), Positives = 159/324 (49%), Gaps = 19/324 (5%)
Query: 95 SRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLL 154
+R T +GFT LH+A + N + T LL+ GA + G+T LH+A+ G+ +LL
Sbjct: 206 NRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLL 265
Query: 155 QHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLN 214
G ++ + TPLH AA GH+QV LLL+ GA + + G PLH+A+ +
Sbjct: 266 DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE 325
Query: 215 IAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL 274
K L++ KA V+ + LH + GH+ + K LL D P+ + G TPL
Sbjct: 326 CVKHLLQH--KAPVDDVTLDYLTALHVAAHCGHYRVTKLLL--DKRANPNARALNGFTPL 381
Query: 275 HLACYNGKFEVAKEIIQISGT-ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVINI 333
H+AC + +V + +++ + +++T+ + T H A G +++V LL QN +
Sbjct: 382 HIACKKNRIKVMELLVKYGASIQAITESGL---TPIHVAAFMGH-LNIVLLLL-QNGASP 436
Query: 334 NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG 393
+ G T LH A G + +V+ LL NGA ++ A ++EQT L A G
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA---------REEQTPLHIASRLG 487
Query: 394 HDAIVTLLKHYKRPQDELPCNEYS 417
IV LL + D N Y+
Sbjct: 488 KTEIVQLLLQHMAHPDAATTNGYT 511
Score = 132 bits (332), Expect = 1e-30
Identities = 104/327 (31%), Positives = 156/327 (47%), Gaps = 25/327 (7%)
Query: 91 GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAA 150
G+ + +NG ALHLA + + L+ LL G+ + G TALHIA++AG E
Sbjct: 33 GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVV 92
Query: 151 DVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAK 210
VL++ GAN+N Q FTPL++AA H V + LL+ GA+ + + E G PL +A +
Sbjct: 93 KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQ 152
Query: 211 GFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSD--LEVQPHVV-- 266
G +L+E +K V LH +R LLQ+D +VQ ++
Sbjct: 153 GHNQAVAILLENDTKGKVRLP------ALHIAARKDDTKSAALLLQNDHNADVQSKMMVN 206
Query: 267 --NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKF 324
G TPLH+A + G VA ++ T N T H A G + ++VK
Sbjct: 207 RTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN--GITPLHVASKRGNT-NMVKL 263
Query: 325 LLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQT 384
LLD+ I+ + RDG T LH A GH ++V+ LL+ GA + + K+ +
Sbjct: 264 LLDRGG-QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL---------LARTKNGLS 313
Query: 385 CLMWAYEKGHDAIVTLLKHYKRPQDEL 411
L A + H V L +K P D++
Sbjct: 314 PLHMAAQGDHVECVKHLLQHKAPVDDV 340
Score = 123 bits (309), Expect = 6e-28
Identities = 102/350 (29%), Positives = 160/350 (45%), Gaps = 52/350 (14%)
Query: 58 VNLNYRTENGLSLLHLCCICGGKKSHI---RTLMLKGLRPSRLTRNGFTALHLAVYKDNA 114
+++N +NGL+ LHL K+ H+ + L+ +G T+ G TALH+A A
Sbjct: 34 IDINTCNQNGLNALHLAA----KEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 89
Query: 115 ELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIA 174
E++ L+ GA+I G T L++A H++ LL++GAN + FTPL +A
Sbjct: 90 EVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 149
Query: 175 AYYGHEQVTRLLLK-------------------------------FGAD------VNVSG 197
GH Q +LL+ AD VN +
Sbjct: 150 LQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTT 209
Query: 198 EVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQS 257
E G PLH+A+ G +N+A LL+ G+ D A++ PLH S+ G+ ++VK LL
Sbjct: 210 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG--ITPLHVASKRGNTNMVKLLLDR 267
Query: 258 DLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGK 317
++ + G TPLH A +G +V + +++ +N S H A G
Sbjct: 268 GGQIDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS--PLHMA-AQGD 322
Query: 318 SIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 367
++ VK LL Q+ ++ D T LH A + GH R+ + LLD A+ N
Sbjct: 323 HVECVKHLL-QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN 371
Score = 115 bits (289), Expect = 1e-25
Identities = 78/265 (29%), Positives = 123/265 (46%), Gaps = 5/265 (1%)
Query: 64 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 123
T+ G + LH+ G + L+ + +NG T LH+A + DN ++ LL
Sbjct: 539 TKKGFTPLHVAAKYGSLDV-AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK 597
Query: 124 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 183
GA G T LHIA ++ A LL +GA NI TPLH+A+ GH +
Sbjct: 598 GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMV 657
Query: 184 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 243
LLL GA++++S + G LHLA+ + +N+A +L + G AD +A + PL
Sbjct: 658 TLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG--ADQDAHTKLGYTPLIVAC 715
Query: 244 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENI 303
+G+ +V +LL+ V N G TPLH A G + ++Q + T N
Sbjct: 716 HYGNVKMVNFLLKQGANVNAKTKN--GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 773
Query: 304 FSETAFHSACTYGKSIDLVKFLLDQ 328
+ A Y +D +K + ++
Sbjct: 774 NTALAIAKRLGYISVVDTLKVVTEE 798
Score = 107 bits (268), Expect = 3e-23
Identities = 72/235 (30%), Positives = 119/235 (50%), Gaps = 15/235 (6%)
Query: 65 ENGLSLLHLCCICGGKKSHIR---TLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL 121
+NG + LH+ KK+ ++ TL+ G + +T+ G T LHLA + + +++T LL
Sbjct: 606 KNGYTPLHIAA----KKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 661
Query: 122 HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQ 181
GA+I GLT+LH+A + AD+L +HGA+ + + +TPL +A +YG+ +
Sbjct: 662 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVK 721
Query: 182 VTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 241
+ LLK GA+VN + G PLH A+ +G +I +L++ G+K NA + L
Sbjct: 722 MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP--NATTANGNTALAI 779
Query: 242 CSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTE 296
R G+ +V L EV I L++ E E++ +S E
Sbjct: 780 AKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVP------ETMTEVLDVSDEE 828
Score = 91.7 bits (226), Expect = 3e-18
Identities = 82/296 (27%), Positives = 134/296 (45%), Gaps = 50/296 (16%)
Query: 141 ATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVG 200
A AG+L+ L+ G ++N + LH+AA GH + + LL G+ V+ + + G
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 201 DRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLE 260
+ LH+AS G + K+L++EG A++NAQ PL+ ++ H D+VKYLL++
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEG--ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 134
Query: 261 VQPHVVNIYGDTPLHLACYNG-------------KFEVAKEIIQISGTESLTKE------ 301
+ G TPL +A G K +V + I+ + TK
Sbjct: 135 QSTATED--GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 192
Query: 302 -------------NIFSETAF---HSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLH 345
N +E+ F H A YG ++++ LL++ ++ R+G T LH
Sbjct: 193 NDHNADVQSKMMVNRTTESGFTPLHIAAHYG-NVNVATLLLNRGAA-VDFTARNGITPLH 250
Query: 346 SACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
A G+ +V+ LLD G ++ + +D T L A GHD +V LL
Sbjct: 251 VASKRGNTNMVKLLLDRGGQID---------AKTRDGLTPLHCAARSGHDQVVELL 297
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 157 bits (396), Expect = 5e-38
Identities = 115/376 (30%), Positives = 172/376 (45%), Gaps = 47/376 (12%)
Query: 60 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 119
++ +T +GL+ LH C G + L+ +G T+NG + LH+A D+ E +
Sbjct: 292 IDAKTRDGLTPLH-CAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350
Query: 120 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 179
LL A + V LTALH+A GH +LL AN N + FTPLHIA
Sbjct: 351 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 410
Query: 180 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD------------ 227
+V LL+K+GA + E G P+H+A+ G LNI LL++ G+ D
Sbjct: 411 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 470
Query: 228 -------------------VNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNI 268
V+A+ E+ PLH SR G +IV+ LLQ P
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH--MAHPDAATT 528
Query: 269 YGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQ 328
G TPLH++ G+ +VA +++ SL + F T H A YG S+D+ K LL +
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF--TPLHVAAKYG-SLDVAKLLLQR 585
Query: 329 NVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMW 388
+ G++G T LH A ++ + ++ LL+ GA + A K+ T L
Sbjct: 586 RAA-ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA---------KNGYTPLHI 635
Query: 389 AYEKGHDAIVTLLKHY 404
A +K I + L +Y
Sbjct: 636 AAKKNQMQIASTLLNY 651
Score = 148 bits (374), Expect = 2e-35
Identities = 104/324 (32%), Positives = 158/324 (48%), Gaps = 17/324 (5%)
Query: 79 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 138
GK ++ L+ P T NG+T LH++ + ++ + LL +GA G T L
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 567
Query: 139 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGE 198
H+A G L+ A +LLQ A + TPLH+AA+Y +++V LLL+ GA + + +
Sbjct: 568 HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK 627
Query: 199 VGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSD 258
G PLH+A+ K + IA L+ G A+ N + PLH S+ GH D+V LL
Sbjct: 628 NGYTPLHIAAKKNQMQIASTLLNYG--AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 685
Query: 259 LEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKS 318
+ H+ G T LHLA K VA +I+ G + + T AC YG +
Sbjct: 686 ANI--HMSTKSGLTSLHLAAQEDKVNVA-DILTKHGADQDAHTKL-GYTPLIVACHYG-N 740
Query: 319 IDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSG 378
+ +V FLL Q N+N + ++G+T LH A GH ++ LL +GA N + +
Sbjct: 741 VKMVNFLLKQGA-NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGN---- 795
Query: 379 EKDEQTCLMWAYEKGHDAIVTLLK 402
T L A G+ ++V LK
Sbjct: 796 -----TALAIAKRLGYISVVDTLK 814
Score = 139 bits (349), Expect = 1e-32
Identities = 113/420 (26%), Positives = 188/420 (44%), Gaps = 89/420 (21%)
Query: 57 KVNLNYRTENGLSLLHLCCICGGKKSHIRTLML---KGLRPSRLTRNGFTALHLAVYKDN 113
+ N N R NG + LH+ C KK+ I+ + L G +T +G T +H+A + +
Sbjct: 388 RANPNARALNGFTPLHIAC----KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGH 443
Query: 114 AELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHI 173
++ LL +GA G TALH+A AG +E LL++GA V+ + TPLHI
Sbjct: 444 LNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 503
Query: 174 AAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDN 233
A+ G ++ +LLL+ A + + G PLH+++ +G +++A +L+E G+ + +
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK-- 561
Query: 234 EDHVPLHFCSRFGHHDIVKYLLQS-------------------------------DLEVQ 262
+ PLH +++G D+ K LLQ +
Sbjct: 562 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 621
Query: 263 PHVVNIYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFSETAFHSACTYGKSIDL 321
PH G TPLH+A + ++A ++ T +TK+ + T H A G + D+
Sbjct: 622 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV---TPLHLASQEGHT-DM 677
Query: 322 VKFLLDQNVININHQGRDGHTGLH---------------------------------SAC 348
V LLD+ NI+ + G T LH AC
Sbjct: 678 VTLLLDKGA-NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVAC 736
Query: 349 YHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIV-TLLKHYKRP 407
++G++++V FLL GA++N + K+ T L A ++GH I+ LL+H +P
Sbjct: 737 HYGNVKMVNFLLKQGANVN---------AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787
Score = 137 bits (344), Expect = 5e-32
Identities = 101/324 (31%), Positives = 159/324 (49%), Gaps = 19/324 (5%)
Query: 95 SRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLL 154
+R T +GFT LH+A + N + T LL+ GA + G+T LH+A+ G+ +LL
Sbjct: 227 NRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLL 286
Query: 155 QHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLN 214
G ++ + TPLH AA GH+QV LLL+ GA + + G PLH+A+ +
Sbjct: 287 DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE 346
Query: 215 IAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL 274
K L++ KA V+ + LH + GH+ + K LL D P+ + G TPL
Sbjct: 347 CVKHLLQH--KAPVDDVTLDYLTALHVAAHCGHYRVTKLLL--DKRANPNARALNGFTPL 402
Query: 275 HLACYNGKFEVAKEIIQISGT-ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVINI 333
H+AC + +V + +++ + +++T+ + T H A G +++V LL QN +
Sbjct: 403 HIACKKNRIKVMELLVKYGASIQAITESGL---TPIHVAAFMGH-LNIVLLLL-QNGASP 457
Query: 334 NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG 393
+ G T LH A G + +V+ LL NGA ++ A ++EQT L A G
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA---------REEQTPLHIASRLG 508
Query: 394 HDAIVTLLKHYKRPQDELPCNEYS 417
IV LL + D N Y+
Sbjct: 509 KTEIVQLLLQHMAHPDAATTNGYT 532
Score = 132 bits (332), Expect = 1e-30
Identities = 104/327 (31%), Positives = 156/327 (47%), Gaps = 25/327 (7%)
Query: 91 GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAA 150
G+ + +NG ALHLA + + L+ LL G+ + G TALHIA++AG E
Sbjct: 54 GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVV 113
Query: 151 DVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAK 210
VL++ GAN+N Q FTPL++AA H V + LL+ GA+ + + E G PL +A +
Sbjct: 114 KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQ 173
Query: 211 GFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSD--LEVQPHVV-- 266
G +L+E +K V LH +R LLQ+D +VQ ++
Sbjct: 174 GHNQAVAILLENDTKGKVRLP------ALHIAARKDDTKSAALLLQNDHNADVQSKMMVN 227
Query: 267 --NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKF 324
G TPLH+A + G VA ++ T N T H A G + ++VK
Sbjct: 228 RTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN--GITPLHVASKRGNT-NMVKL 284
Query: 325 LLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQT 384
LLD+ I+ + RDG T LH A GH ++V+ LL+ GA + + K+ +
Sbjct: 285 LLDRGG-QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL---------LARTKNGLS 334
Query: 385 CLMWAYEKGHDAIVTLLKHYKRPQDEL 411
L A + H V L +K P D++
Sbjct: 335 PLHMAAQGDHVECVKHLLQHKAPVDDV 361
Score = 123 bits (309), Expect = 6e-28
Identities = 102/350 (29%), Positives = 160/350 (45%), Gaps = 52/350 (14%)
Query: 58 VNLNYRTENGLSLLHLCCICGGKKSHI---RTLMLKGLRPSRLTRNGFTALHLAVYKDNA 114
+++N +NGL+ LHL K+ H+ + L+ +G T+ G TALH+A A
Sbjct: 55 IDINTCNQNGLNALHLAA----KEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 110
Query: 115 ELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIA 174
E++ L+ GA+I G T L++A H++ LL++GAN + FTPL +A
Sbjct: 111 EVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 170
Query: 175 AYYGHEQVTRLLLK-------------------------------FGAD------VNVSG 197
GH Q +LL+ AD VN +
Sbjct: 171 LQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTT 230
Query: 198 EVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQS 257
E G PLH+A+ G +N+A LL+ G+ D A++ PLH S+ G+ ++VK LL
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG--ITPLHVASKRGNTNMVKLLLDR 288
Query: 258 DLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGK 317
++ + G TPLH A +G +V + +++ +N S H A G
Sbjct: 289 GGQIDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS--PLHMA-AQGD 343
Query: 318 SIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 367
++ VK LL Q+ ++ D T LH A + GH R+ + LLD A+ N
Sbjct: 344 HVECVKHLL-QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN 392
Score = 115 bits (289), Expect = 1e-25
Identities = 78/265 (29%), Positives = 123/265 (46%), Gaps = 5/265 (1%)
Query: 64 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 123
T+ G + LH+ G + L+ + +NG T LH+A + DN ++ LL
Sbjct: 560 TKKGFTPLHVAAKYGSLDV-AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK 618
Query: 124 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 183
GA G T LHIA ++ A LL +GA NI TPLH+A+ GH +
Sbjct: 619 GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMV 678
Query: 184 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 243
LLL GA++++S + G LHLA+ + +N+A +L + G AD +A + PL
Sbjct: 679 TLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG--ADQDAHTKLGYTPLIVAC 736
Query: 244 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENI 303
+G+ +V +LL+ V N G TPLH A G + ++Q + T N
Sbjct: 737 HYGNVKMVNFLLKQGANVNAKTKN--GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 794
Query: 304 FSETAFHSACTYGKSIDLVKFLLDQ 328
+ A Y +D +K + ++
Sbjct: 795 NTALAIAKRLGYISVVDTLKVVTEE 819
Score = 107 bits (268), Expect = 3e-23
Identities = 72/235 (30%), Positives = 119/235 (50%), Gaps = 15/235 (6%)
Query: 65 ENGLSLLHLCCICGGKKSHIR---TLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL 121
+NG + LH+ KK+ ++ TL+ G + +T+ G T LHLA + + +++T LL
Sbjct: 627 KNGYTPLHIAA----KKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Query: 122 HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQ 181
GA+I GLT+LH+A + AD+L +HGA+ + + +TPL +A +YG+ +
Sbjct: 683 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVK 742
Query: 182 VTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 241
+ LLK GA+VN + G PLH A+ +G +I +L++ G+K NA + L
Sbjct: 743 MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP--NATTANGNTALAI 800
Query: 242 CSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTE 296
R G+ +V L EV I L++ E E++ +S E
Sbjct: 801 AKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVP------ETMTEVLDVSDEE 849
Score = 91.7 bits (226), Expect = 3e-18
Identities = 82/296 (27%), Positives = 134/296 (45%), Gaps = 50/296 (16%)
Query: 141 ATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVG 200
A AG+L+ L+ G ++N + LH+AA GH + + LL G+ V+ + + G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 201 DRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLE 260
+ LH+AS G + K+L++EG A++NAQ PL+ ++ H D+VKYLL++
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEG--ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 261 VQPHVVNIYGDTPLHLACYNG-------------KFEVAKEIIQISGTESLTKE------ 301
+ G TPL +A G K +V + I+ + TK
Sbjct: 156 QSTATED--GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 302 -------------NIFSETAF---HSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLH 345
N +E+ F H A YG ++++ LL++ ++ R+G T LH
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYG-NVNVATLLLNRGAA-VDFTARNGITPLH 271
Query: 346 SACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
A G+ +V+ LLD G ++ + +D T L A GHD +V LL
Sbjct: 272 VASKRGNTNMVKLLLDRGGQID---------AKTRDGLTPLHCAARSGHDQVVELL 318
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 157 bits (396), Expect = 5e-38
Identities = 115/376 (30%), Positives = 172/376 (45%), Gaps = 47/376 (12%)
Query: 60 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 119
++ +T +GL+ LH C G + L+ +G T+NG + LH+A D+ E +
Sbjct: 292 IDAKTRDGLTPLH-CAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350
Query: 120 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 179
LL A + V LTALH+A GH +LL AN N + FTPLHIA
Sbjct: 351 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 410
Query: 180 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD------------ 227
+V LL+K+GA + E G P+H+A+ G LNI LL++ G+ D
Sbjct: 411 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 470
Query: 228 -------------------VNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNI 268
V+A+ E+ PLH SR G +IV+ LLQ P
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH--MAHPDAATT 528
Query: 269 YGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQ 328
G TPLH++ G+ +VA +++ SL + F T H A YG S+D+ K LL +
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF--TPLHVAAKYG-SLDVAKLLLQR 585
Query: 329 NVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMW 388
+ G++G T LH A ++ + ++ LL+ GA + A K+ T L
Sbjct: 586 RAA-ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA---------KNGYTPLHI 635
Query: 389 AYEKGHDAIVTLLKHY 404
A +K I + L +Y
Sbjct: 636 AAKKNQMQIASTLLNY 651
Score = 148 bits (374), Expect = 2e-35
Identities = 104/324 (32%), Positives = 158/324 (48%), Gaps = 17/324 (5%)
Query: 79 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 138
GK ++ L+ P T NG+T LH++ + ++ + LL +GA G T L
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 567
Query: 139 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGE 198
H+A G L+ A +LLQ A + TPLH+AA+Y +++V LLL+ GA + + +
Sbjct: 568 HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK 627
Query: 199 VGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSD 258
G PLH+A+ K + IA L+ G A+ N + PLH S+ GH D+V LL
Sbjct: 628 NGYTPLHIAAKKNQMQIASTLLNYG--AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 685
Query: 259 LEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKS 318
+ H+ G T LHLA K VA +I+ G + + T AC YG +
Sbjct: 686 ANI--HMSTKSGLTSLHLAAQEDKVNVA-DILTKHGADQDAHTKL-GYTPLIVACHYG-N 740
Query: 319 IDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSG 378
+ +V FLL Q N+N + ++G+T LH A GH ++ LL +GA N + +
Sbjct: 741 VKMVNFLLKQGA-NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGN---- 795
Query: 379 EKDEQTCLMWAYEKGHDAIVTLLK 402
T L A G+ ++V LK
Sbjct: 796 -----TALAIAKRLGYISVVDTLK 814
Score = 139 bits (349), Expect = 1e-32
Identities = 113/420 (26%), Positives = 188/420 (44%), Gaps = 89/420 (21%)
Query: 57 KVNLNYRTENGLSLLHLCCICGGKKSHIRTLML---KGLRPSRLTRNGFTALHLAVYKDN 113
+ N N R NG + LH+ C KK+ I+ + L G +T +G T +H+A + +
Sbjct: 388 RANPNARALNGFTPLHIAC----KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGH 443
Query: 114 AELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHI 173
++ LL +GA G TALH+A AG +E LL++GA V+ + TPLHI
Sbjct: 444 LNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 503
Query: 174 AAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDN 233
A+ G ++ +LLL+ A + + G PLH+++ +G +++A +L+E G+ + +
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK-- 561
Query: 234 EDHVPLHFCSRFGHHDIVKYLLQS-------------------------------DLEVQ 262
+ PLH +++G D+ K LLQ +
Sbjct: 562 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 621
Query: 263 PHVVNIYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFSETAFHSACTYGKSIDL 321
PH G TPLH+A + ++A ++ T +TK+ + T H A G + D+
Sbjct: 622 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV---TPLHLASQEGHT-DM 677
Query: 322 VKFLLDQNVININHQGRDGHTGLH---------------------------------SAC 348
V LLD+ NI+ + G T LH AC
Sbjct: 678 VTLLLDKGA-NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVAC 736
Query: 349 YHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIV-TLLKHYKRP 407
++G++++V FLL GA++N + K+ T L A ++GH I+ LL+H +P
Sbjct: 737 HYGNVKMVNFLLKQGANVN---------AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787
Score = 137 bits (344), Expect = 5e-32
Identities = 101/324 (31%), Positives = 159/324 (49%), Gaps = 19/324 (5%)
Query: 95 SRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLL 154
+R T +GFT LH+A + N + T LL+ GA + G+T LH+A+ G+ +LL
Sbjct: 227 NRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLL 286
Query: 155 QHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLN 214
G ++ + TPLH AA GH+QV LLL+ GA + + G PLH+A+ +
Sbjct: 287 DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE 346
Query: 215 IAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL 274
K L++ KA V+ + LH + GH+ + K LL D P+ + G TPL
Sbjct: 347 CVKHLLQH--KAPVDDVTLDYLTALHVAAHCGHYRVTKLLL--DKRANPNARALNGFTPL 402
Query: 275 HLACYNGKFEVAKEIIQISGT-ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVINI 333
H+AC + +V + +++ + +++T+ + T H A G +++V LL QN +
Sbjct: 403 HIACKKNRIKVMELLVKYGASIQAITESGL---TPIHVAAFMGH-LNIVLLLL-QNGASP 457
Query: 334 NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG 393
+ G T LH A G + +V+ LL NGA ++ A ++EQT L A G
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA---------REEQTPLHIASRLG 508
Query: 394 HDAIVTLLKHYKRPQDELPCNEYS 417
IV LL + D N Y+
Sbjct: 509 KTEIVQLLLQHMAHPDAATTNGYT 532
Score = 132 bits (332), Expect = 1e-30
Identities = 104/327 (31%), Positives = 156/327 (47%), Gaps = 25/327 (7%)
Query: 91 GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAA 150
G+ + +NG ALHLA + + L+ LL G+ + G TALHIA++AG E
Sbjct: 54 GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVV 113
Query: 151 DVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAK 210
VL++ GAN+N Q FTPL++AA H V + LL+ GA+ + + E G PL +A +
Sbjct: 114 KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQ 173
Query: 211 GFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSD--LEVQPHVV-- 266
G +L+E +K V LH +R LLQ+D +VQ ++
Sbjct: 174 GHNQAVAILLENDTKGKVRLP------ALHIAARKDDTKSAALLLQNDHNADVQSKMMVN 227
Query: 267 --NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKF 324
G TPLH+A + G VA ++ T N T H A G + ++VK
Sbjct: 228 RTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN--GITPLHVASKRGNT-NMVKL 284
Query: 325 LLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQT 384
LLD+ I+ + RDG T LH A GH ++V+ LL+ GA + + K+ +
Sbjct: 285 LLDRGG-QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL---------LARTKNGLS 334
Query: 385 CLMWAYEKGHDAIVTLLKHYKRPQDEL 411
L A + H V L +K P D++
Sbjct: 335 PLHMAAQGDHVECVKHLLQHKAPVDDV 361
Score = 123 bits (309), Expect = 6e-28
Identities = 102/350 (29%), Positives = 160/350 (45%), Gaps = 52/350 (14%)
Query: 58 VNLNYRTENGLSLLHLCCICGGKKSHI---RTLMLKGLRPSRLTRNGFTALHLAVYKDNA 114
+++N +NGL+ LHL K+ H+ + L+ +G T+ G TALH+A A
Sbjct: 55 IDINTCNQNGLNALHLAA----KEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 110
Query: 115 ELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIA 174
E++ L+ GA+I G T L++A H++ LL++GAN + FTPL +A
Sbjct: 111 EVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 170
Query: 175 AYYGHEQVTRLLLK-------------------------------FGAD------VNVSG 197
GH Q +LL+ AD VN +
Sbjct: 171 LQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTT 230
Query: 198 EVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQS 257
E G PLH+A+ G +N+A LL+ G+ D A++ PLH S+ G+ ++VK LL
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG--ITPLHVASKRGNTNMVKLLLDR 288
Query: 258 DLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGK 317
++ + G TPLH A +G +V + +++ +N S H A G
Sbjct: 289 GGQIDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS--PLHMA-AQGD 343
Query: 318 SIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 367
++ VK LL Q+ ++ D T LH A + GH R+ + LLD A+ N
Sbjct: 344 HVECVKHLL-QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN 392
Score = 115 bits (289), Expect = 1e-25
Identities = 78/265 (29%), Positives = 123/265 (46%), Gaps = 5/265 (1%)
Query: 64 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 123
T+ G + LH+ G + L+ + +NG T LH+A + DN ++ LL
Sbjct: 560 TKKGFTPLHVAAKYGSLDV-AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK 618
Query: 124 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 183
GA G T LHIA ++ A LL +GA NI TPLH+A+ GH +
Sbjct: 619 GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMV 678
Query: 184 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 243
LLL GA++++S + G LHLA+ + +N+A +L + G AD +A + PL
Sbjct: 679 TLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG--ADQDAHTKLGYTPLIVAC 736
Query: 244 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENI 303
+G+ +V +LL+ V N G TPLH A G + ++Q + T N
Sbjct: 737 HYGNVKMVNFLLKQGANVNAKTKN--GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 794
Query: 304 FSETAFHSACTYGKSIDLVKFLLDQ 328
+ A Y +D +K + ++
Sbjct: 795 NTALAIAKRLGYISVVDTLKVVTEE 819
Score = 107 bits (268), Expect = 3e-23
Identities = 72/235 (30%), Positives = 119/235 (50%), Gaps = 15/235 (6%)
Query: 65 ENGLSLLHLCCICGGKKSHIR---TLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL 121
+NG + LH+ KK+ ++ TL+ G + +T+ G T LHLA + + +++T LL
Sbjct: 627 KNGYTPLHIAA----KKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Query: 122 HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQ 181
GA+I GLT+LH+A + AD+L +HGA+ + + +TPL +A +YG+ +
Sbjct: 683 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVK 742
Query: 182 VTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 241
+ LLK GA+VN + G PLH A+ +G +I +L++ G+K NA + L
Sbjct: 743 MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP--NATTANGNTALAI 800
Query: 242 CSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTE 296
R G+ +V L EV I L++ E E++ +S E
Sbjct: 801 AKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVP------ETMTEVLDVSDEE 849
Score = 91.7 bits (226), Expect = 3e-18
Identities = 82/296 (27%), Positives = 134/296 (45%), Gaps = 50/296 (16%)
Query: 141 ATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVG 200
A AG+L+ L+ G ++N + LH+AA GH + + LL G+ V+ + + G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 201 DRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLE 260
+ LH+AS G + K+L++EG A++NAQ PL+ ++ H D+VKYLL++
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEG--ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 261 VQPHVVNIYGDTPLHLACYNG-------------KFEVAKEIIQISGTESLTKE------ 301
+ G TPL +A G K +V + I+ + TK
Sbjct: 156 QSTATED--GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 302 -------------NIFSETAF---HSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLH 345
N +E+ F H A YG ++++ LL++ ++ R+G T LH
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYG-NVNVATLLLNRGAA-VDFTARNGITPLH 271
Query: 346 SACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
A G+ +V+ LLD G ++ + +D T L A GHD +V LL
Sbjct: 272 VASKRGNTNMVKLLLDRGGQID---------AKTRDGLTPLHCAARSGHDQVVELL 318
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 155 bits (392), Expect = 1e-37
Identities = 99/283 (34%), Positives = 149/283 (52%), Gaps = 21/283 (7%)
Query: 450 AGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKS-DVDMFCR 508
AGL + E++ EIIG G FGKVY+ R + VA+K R + + + C+
Sbjct: 85 AGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQ 144
Query: 509 EVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLII-- 566
E + L HP +I GACLN P +V +Y GG+L +L ++ + +++
Sbjct: 145 EARLFGALQHPNIIALRGACLNPP-HLCLVMEYARGGALSRVLAGRR----VPPHVLVNW 199
Query: 567 AVDVAKGMEYLHN-LTQPIIHRDLNSHNILLYE--------DGHAVVADFGESRFLQSLD 617
AV VA+GM YLHN PIIHRDL S NIL+ E D + DFG +R
Sbjct: 200 AVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR---EWH 256
Query: 618 EDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADM 677
+ G WMAPEV + + ++ +DV+S+ + LWE+LTGE+P+ + A A +
Sbjct: 257 KTTKMSAAGTYAWMAPEVI-RLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGV 315
Query: 678 AYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLE 720
A + + PI + P+P + LL W+ P GRP+F ++ +LE
Sbjct: 316 AMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLE 358
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 155 bits (391), Expect = 2e-37
Identities = 96/264 (36%), Positives = 147/264 (55%), Gaps = 18/264 (6%)
Query: 458 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN 517
+ EIE E++G G+FG V K + R K VAIK+ S+S+ F E+ L ++N
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIE-----SESERKAFIVELRQLSRVN 85
Query: 518 HPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGME 575
HP +++ GACLN +V +Y GGSL+++LH E + + ++G+
Sbjct: 86 HPNIVKLYGACLNP---VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
Query: 576 YLHNLT-QPIIHRDLNSHNILLYEDGHAV-VADFGESRFLQSLDEDNMTKQPGNLRWMAP 633
YLH++ + +IHRDL N+LL G + + DFG + +Q+ +MT G+ WMAP
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT----HMTNNKGSAAWMAP 198
Query: 634 EVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHH-IRPPIGYSIPK 692
EVF + + Y+ K DVFS+ + LWE++T PF + A A H+ RPP+ ++PK
Sbjct: 199 EVF-EGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPK 257
Query: 693 PISSLLIRGWNACPEGRPEFSEVV 716
PI SL+ R W+ P RP E+V
Sbjct: 258 PIESLMTRCWSKDPSQRPSMEEIV 281
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 155 bits (391), Expect = 2e-37
Identities = 96/264 (36%), Positives = 147/264 (55%), Gaps = 18/264 (6%)
Query: 458 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN 517
+ EIE E++G G+FG V K + R K VAIK+ S+S+ F E+ L ++N
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIE-----SESERKAFIVELRQLSRVN 85
Query: 518 HPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGME 575
HP +++ GACLN +V +Y GGSL+++LH E + + ++G+
Sbjct: 86 HPNIVKLYGACLNP---VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
Query: 576 YLHNLT-QPIIHRDLNSHNILLYEDGHAV-VADFGESRFLQSLDEDNMTKQPGNLRWMAP 633
YLH++ + +IHRDL N+LL G + + DFG + +Q+ +MT G+ WMAP
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT----HMTNNKGSAAWMAP 198
Query: 634 EVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHH-IRPPIGYSIPK 692
EVF + + Y+ K DVFS+ + LWE++T PF + A A H+ RPP+ ++PK
Sbjct: 199 EVF-EGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPK 257
Query: 693 PISSLLIRGWNACPEGRPEFSEVV 716
PI SL+ R W+ P RP E+V
Sbjct: 258 PIESLMTRCWSKDPSQRPSMEEIV 281
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 155 bits (391), Expect = 2e-37
Identities = 96/264 (36%), Positives = 147/264 (55%), Gaps = 18/264 (6%)
Query: 458 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN 517
+ EIE E++G G+FG V K + R K VAIK+ S+S+ F E+ L ++N
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIE-----SESERKAFIVELRQLSRVN 85
Query: 518 HPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGME 575
HP +++ GACLN +V +Y GGSL+++LH E + + ++G+
Sbjct: 86 HPNIVKLYGACLNP---VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
Query: 576 YLHNLT-QPIIHRDLNSHNILLYEDGHAV-VADFGESRFLQSLDEDNMTKQPGNLRWMAP 633
YLH++ + +IHRDL N+LL G + + DFG + +Q+ +MT G+ WMAP
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT----HMTNNKGSAAWMAP 198
Query: 634 EVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHH-IRPPIGYSIPK 692
EVF + + Y+ K DVFS+ + LWE++T PF + A A H+ RPP+ ++PK
Sbjct: 199 EVF-EGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPK 257
Query: 693 PISSLLIRGWNACPEGRPEFSEVV 716
PI SL+ R W+ P RP E+V
Sbjct: 258 PIESLMTRCWSKDPSQRPSMEEIV 281
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 155 bits (391), Expect = 2e-37
Identities = 96/264 (36%), Positives = 147/264 (55%), Gaps = 18/264 (6%)
Query: 458 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN 517
+ EIE E++G G+FG V K + R K VAIK+ S+S+ F E+ L ++N
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIE-----SESERKAFIVELRQLSRVN 85
Query: 518 HPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGME 575
HP +++ GACLN +V +Y GGSL+++LH E + + ++G+
Sbjct: 86 HPNIVKLYGACLNP---VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
Query: 576 YLHNLT-QPIIHRDLNSHNILLYEDGHAV-VADFGESRFLQSLDEDNMTKQPGNLRWMAP 633
YLH++ + +IHRDL N+LL G + + DFG + +Q+ +MT G+ WMAP
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT----HMTNNKGSAAWMAP 198
Query: 634 EVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHH-IRPPIGYSIPK 692
EVF + + Y+ K DVFS+ + LWE++T PF + A A H+ RPP+ ++PK
Sbjct: 199 EVF-EGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPK 257
Query: 693 PISSLLIRGWNACPEGRPEFSEVV 716
PI SL+ R W+ P RP E+V
Sbjct: 258 PIESLMTRCWSKDPSQRPSMEEIV 281
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 141 bits (356), Expect = 2e-33
Identities = 93/271 (34%), Positives = 139/271 (51%), Gaps = 20/271 (7%)
Query: 454 SHFHLQLSEIEFHEIIGSGSFGKVYKGR--CRNKIVAIKRYRANTYCSKSDVDMFCREVS 511
S ++ +++F E G GSFG VY+ + ++K VA+K+ +E
Sbjct: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----------KEAE 55
Query: 512 ILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQK-RILDLQSKLIIAVDV 570
IL L+H +IQF G L +P + IVT+Y S GSL+ ++ + +D+ + A DV
Sbjct: 56 ILSVLSHRNIIQFYGVIL-EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDV 114
Query: 571 AKGMEYLH-NLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLR 629
AKGM YLH +IHRDL S N+++ DG + DFG SRF ++ G
Sbjct: 115 AKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLV---GTFP 171
Query: 630 WMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYS 689
WMAPEV Q + D +SY + LWE+LT E+PF L+ A + + R I S
Sbjct: 172 WMAPEVI-QSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSS 230
Query: 690 IPKPISSLLIRGWNACPEGRPEFSEVVMKLE 720
P+ + LL + W A + RP F +++ LE
Sbjct: 231 CPRSFAELLHQCWEADAKKRPSFKQIISILE 261
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 141 bits (356), Expect = 2e-33
Identities = 93/271 (34%), Positives = 139/271 (51%), Gaps = 20/271 (7%)
Query: 454 SHFHLQLSEIEFHEIIGSGSFGKVYKGR--CRNKIVAIKRYRANTYCSKSDVDMFCREVS 511
S ++ +++F E G GSFG VY+ + ++K VA+K+ +E
Sbjct: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----------KEAE 55
Query: 512 ILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQK-RILDLQSKLIIAVDV 570
IL L+H +IQF G L +P + IVT+Y S GSL+ ++ + +D+ + A DV
Sbjct: 56 ILSVLSHRNIIQFYGVIL-EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDV 114
Query: 571 AKGMEYLH-NLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLR 629
AKGM YLH +IHRDL S N+++ DG + DFG SRF ++ G
Sbjct: 115 AKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLV---GTFP 171
Query: 630 WMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYS 689
WMAPEV Q + D +SY + LWE+LT E+PF L+ A + + R I S
Sbjct: 172 WMAPEVI-QSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSS 230
Query: 690 IPKPISSLLIRGWNACPEGRPEFSEVVMKLE 720
P+ + LL + W A + RP F +++ LE
Sbjct: 231 CPRSFAELLHQCWEADAKKRPSFKQIISILE 261
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 139 bits (349), Expect = 1e-32
Identities = 89/271 (32%), Positives = 140/271 (51%), Gaps = 21/271 (7%)
Query: 462 EIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKS-DVDMFCREVSILCQLNHPC 520
E+ E+IG G FGKVY+G R ++VA+K R + S + +E + L HP
Sbjct: 116 ELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPN 175
Query: 521 VIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLII--AVDVAKGMEYLH 578
+I CL +P+ +V +Y +GG L L ++ + +++ AV +A+GM YLH
Sbjct: 176 IIALKAVCLEEPN-LCLVMEYAAGGPLSRALAGRR----VPPHVLVNWAVQIARGMHYLH 230
Query: 579 -NLTQPIIHRDLNSHNILLY--------EDGHAVVADFGESRFLQSLDEDNMTKQPGNLR 629
P+IHRDL S+NILL E + DFG +R + G
Sbjct: 231 CEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAR---EWHKTTQMSAAGTYA 287
Query: 630 WMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYS 689
WMAPEV T ++ +DV+S+ + LWE+LTGE+P+ + A A +A + + PI +
Sbjct: 288 WMAPEVIKAST-FSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPST 346
Query: 690 IPKPISSLLIRGWNACPEGRPEFSEVVMKLE 720
P+P + L+ W P RP+F+ ++ +LE
Sbjct: 347 CPEPFAQLMADCWAQDPHRRPDFASILQQLE 377
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 137 bits (345), Expect = 4e-32
Identities = 103/340 (30%), Positives = 167/340 (49%), Gaps = 19/340 (5%)
Query: 65 ENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSG 124
++G SLLHL + G++ + L+L P+ R G T LH+AV + ++ LL
Sbjct: 436 DSGASLLHLA-VEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARK 494
Query: 125 ADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTR 184
+ TALH A G + +LL+ A+VN D TP+H+A +G E + R
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
Query: 185 LLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSR 244
+LL+ G DV++ G+ PLH A+ +G L I KLL ++ VNAQ + PLH ++
Sbjct: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG-VSVNAQTLDGRTPLHLAAQ 613
Query: 245 FGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEII-QISGTESLTKENI 303
GH+ + + L+ DL +V ++ TPLH+A G A+ ++ + +G E++T +
Sbjct: 614 RGHYRVARILI--DLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGY 671
Query: 304 FSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNG 363
TA H A G + VK L+++ ++ +G T LH A HGH +V+
Sbjct: 672 ---TALHLAARNG-HLATVKLLVEEKA-DVLARGPLNQTALHLAAAHGHSEVVE------ 720
Query: 364 ADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKH 403
LV+ D E+ + A + + TLL+H
Sbjct: 721 ---ELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRH 757
Score = 87.0 bits (214), Expect = 6e-17
Identities = 76/269 (28%), Positives = 129/269 (47%), Gaps = 18/269 (6%)
Query: 467 EIIGSGSFGKVYKGRCRN--KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQF 524
E +GSG FG+VYK R + +AIK + + +++ E + ++
Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELL-EEAKKMEMAKFRYILPV 84
Query: 525 VGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPI 584
G C +P +V +Y+ GSL LL + DL+ ++I + A GM +LH + P+
Sbjct: 85 YGIC-REP--VGLVMEYMETGSLEKLLASEPLPWDLRFRIIH--ETAVGMNFLHCMAPPL 139
Query: 585 IHRDLNSHNILLYEDGHAVVADFGESRF--LQSLDEDNMTKQPGNLRWMAPEVFTQCTR- 641
+H DL NILL H ++DFG ++ L + +M G + ++ PE + +R
Sbjct: 140 LHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRL 199
Query: 642 YTIKADVFSYALCLWEILTGEIPFA---HLKPAAAAADMAYHHIRPPIGYSIPKPIS--- 695
+ K DV+S+A+ +W +LT + PFA ++ + PP+ + P+ S
Sbjct: 200 FDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCRARPRACSHLI 259
Query: 696 SLLIRGWNACPEGRPEFSEVVMKLEECLC 724
L+ R W P RP F E+ + E+ LC
Sbjct: 260 RLMQRCWQGDPRVRPTFQEITSETED-LC 287
Score = 62.8 bits (151), Expect = 1e-09
Identities = 38/117 (32%), Positives = 58/117 (49%), Gaps = 1/117 (0%)
Query: 79 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 138
G S R L+ +G +T +G+TALHLA + + L+ AD+ G TAL
Sbjct: 648 GHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTAL 707
Query: 139 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNV 195
H+A GH E + L+ +++ D + LH+AA H Q LL+ GA +N+
Sbjct: 708 HLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINL 763
Score = 50.4 bits (119), Expect = 7e-06
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 8/107 (7%)
Query: 64 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNG---FTALHLAVYKDNAELITSL 120
T +G + LHL + H+ T+ L + + G TALHLA ++E++ L
Sbjct: 667 TSDGYTALHLAA----RNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEEL 722
Query: 121 LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVF 167
+ + I GL+ALH+A H + + LL+HGA++N+Q F
Sbjct: 723 VSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKF 768
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 135 bits (341), Expect = 1e-31
Identities = 95/277 (34%), Positives = 142/277 (51%), Gaps = 22/277 (7%)
Query: 458 LQLSEIEF-----HEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD-VDMFCREVS 511
+QL EI+F EIIG G FGKVY+ VA+K R + S ++ +E
Sbjct: 134 IQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAK 193
Query: 512 ILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVA 571
+ L HP +I G CL +P+ +V ++ GG L +L ++ D+ AV +A
Sbjct: 194 LFAMLKHPNIIALRGVCLKEPN-LCLVMEFARGGPLNRVLSGKRIPPDILVNW--AVQIA 250
Query: 572 KGMEYLHN-LTQPIIHRDLNSHNILLY---EDGHAV-----VADFGESRFLQSLDEDNMT 622
+GM YLH+ PIIHRDL S NIL+ E+G + DFG +R
Sbjct: 251 RGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR---EWHRTTKM 307
Query: 623 KQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHI 682
G WMAPEV + + ++ +DV+SY + LWE+LTGE+PF + A A +A + +
Sbjct: 308 SAAGTYAWMAPEVI-RASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKL 366
Query: 683 RPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKL 719
PI + P+P + L+ WN P RP F+ ++ +L
Sbjct: 367 ALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL 403
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 135 bits (339), Expect = 2e-31
Identities = 100/351 (28%), Positives = 163/351 (46%), Gaps = 49/351 (13%)
Query: 84 IRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATI 143
+R+L+ + + L + T LH A Y + ++ LL SGA++ LT LH A
Sbjct: 24 VRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAA 83
Query: 144 AGHLEAADVLLQHGANVNIQDAVFFTPLHIAA---------------------------- 175
+ + + +LL H A+VN +D ++ TPLH+AA
Sbjct: 84 SRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSA 143
Query: 176 -----YYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNA 230
+ GH + LLL GA +NV + +PLH A+ G L + KLL+ G AD+
Sbjct: 144 LHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARG--ADLGC 201
Query: 231 QDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEII 290
+D + + LH + G ++VKYLL+ E+ N +G+T LH+ACY G+ VA E++
Sbjct: 202 KDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEP--NAFGNTALHIACYLGQDAVAIELV 259
Query: 291 QISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYH 350
+ + F+ + T G L LL N ++N+Q ++G + LH A H
Sbjct: 260 NAGANVNQPNDKGFTPLHVAAVSTNGA---LCLELLVNNGADVNYQSKEGKSPLHMAAIH 316
Query: 351 GHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
G Q L+ NG++++ +K T L A GH+ +++ L
Sbjct: 317 GRFTRSQILIQNGSEID---------CADKFGNTPLHVAARYGHELLISTL 358
Score = 114 bits (285), Expect = 4e-25
Identities = 84/288 (29%), Positives = 136/288 (47%), Gaps = 32/288 (11%)
Query: 84 IRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATI 143
++ L+ +G R G+ LH A E++ LL GA+I + G TALHIA
Sbjct: 189 LKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACY 248
Query: 144 AGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT-RLLLKFGADVNVSGEVGDR 202
G A L+ GANVN + FTPLH+AA + + LL+ GADVN + G
Sbjct: 249 LGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKS 308
Query: 203 PLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQ 262
PLH+A+ G +++L++ GS+ D D + PLH +R+GH ++ L+ + +
Sbjct: 309 PLHMAAIHGRFTRSQILIQNGSEID--CADKFGNTPLHVAARYGHELLISTLMTNGADTA 366
Query: 263 PHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLV 322
I+ PLHLA G + ++++ + G+ +V
Sbjct: 367 RR--GIHDMFPLHLAVLFGFSDCCRKLL-----------------------SSGQLYSIV 401
Query: 323 KFLLDQNVIN----INHQGRDGHTGLHSACYHGHIRLVQFLLDNGADM 366
L +++V++ IN G T LH+A G++ + LL +GAD+
Sbjct: 402 SSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADL 449
Score = 110 bits (275), Expect = 5e-24
Identities = 90/337 (26%), Positives = 147/337 (43%), Gaps = 46/337 (13%)
Query: 67 GLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL-HSGA 125
G + LH+ C G I L+ G ++ GFT LH+A N L LL ++GA
Sbjct: 239 GNTALHIACYLGQDAVAIE-LVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGA 297
Query: 126 DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRL 185
D+ G + LH+A I G + +L+Q+G+ ++ D TPLH+AA YGHE +
Sbjct: 298 DVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLIST 357
Query: 186 LLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEG----------------SKADVN 229
L+ GAD G PLHLA GF + + L+ G + D+N
Sbjct: 358 LMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDIN 417
Query: 230 AQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEI 289
DN LH + G+ + + LL S +++ + +G TPLH A NG ++ A +
Sbjct: 418 TPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRR--DKFGRTPLHYAAANGSYQCAVTL 475
Query: 290 IQ------------ISGTESLTKENIFSETAFHSACTYGKSID-------------LVKF 324
+ S + + H+ ++ D ++F
Sbjct: 476 VTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEF 535
Query: 325 LLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLD 361
LLD N + + + R G+T +H A +G+ + ++ LL+
Sbjct: 536 LLD-NGADPSLRDRQGYTAVHYAAAYGNRQNLELLLE 571
Score = 102 bits (254), Expect = 1e-21
Identities = 95/334 (28%), Positives = 143/334 (42%), Gaps = 49/334 (14%)
Query: 105 LHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQD 164
LHLA Y + E + +L + ++ + G TAL +AT G E +VL HGA+ I++
Sbjct: 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
Query: 165 AV-FFTPLHIAAYYGHEQVTRLLLKFG--ADV-NVSGEVGDRPLHLASAKGFLNIAKLLM 220
+TPLH AA GH LL+ G AD+ +V G PL LA G ++ LL+
Sbjct: 649 RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLL 708
Query: 221 EEGSKAD-------------------------------VNAQDNEDHVPLHFCSRFGHHD 249
E+GS AD V +D + P+H S GH
Sbjct: 709 EKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTA 768
Query: 250 IVKYLLQSDLEVQP--HVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSET 307
+++ LLQ+ L P V+ G +P+H A Y G E E++ S + N F T
Sbjct: 769 VLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTG-HEDCLELLLEHSPFSYLEGNPF--T 825
Query: 308 AFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 367
H A + L +N + G T LH+A + ++ ++ LL + A++N
Sbjct: 826 PLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVN 885
Query: 368 LVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
+ + +T LM A E G A V L
Sbjct: 886 ---------ATDHTGRTALMTAAENGQTAAVEFL 910
Score = 92.8 bits (229), Expect = 1e-18
Identities = 107/421 (25%), Positives = 161/421 (38%), Gaps = 89/421 (21%)
Query: 59 NLNYRTENGLSLLHLCCICG--------------------------------GKKSHIRT 86
++NY+++ G S LH+ I G G + I T
Sbjct: 298 DVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLIST 357
Query: 87 LMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGA------------------DIQ 128
LM G +R + LHLAV ++ LL SG DI
Sbjct: 358 LMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDIN 417
Query: 129 QVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLK 188
G T LH A G++E ++LL GA++ +D TPLH AA G Q L+
Sbjct: 418 TPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVT 477
Query: 189 FGADVNVSGEVGDRPLHLASAKGFLNIA----------------------------KLLM 220
GA VN + G PLH A+A A + L+
Sbjct: 478 AGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLL 537
Query: 221 EEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYN 280
+ G AD + +D + + +H+ + +G+ ++ LL+ V + +PLHLA YN
Sbjct: 538 DNG--ADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYN 595
Query: 281 GKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDG 340
G E K + + +L + TA A G S + V+ L + + +
Sbjct: 596 GHCEALKTLAET--LVNLDVRDHKGRTALFLATERG-STECVEVLTAHGASALIKERKRK 652
Query: 341 HTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTL 400
T LH+A GH + L+D+G ++ D + G QT LM A GH V L
Sbjct: 653 WTPLHAAAASGHTDSLHLLIDSGERADIT--DVMDAYG----QTPLMLAIMNGHVDCVHL 706
Query: 401 L 401
L
Sbjct: 707 L 707
Score = 92.8 bits (229), Expect = 1e-18
Identities = 77/288 (26%), Positives = 131/288 (45%), Gaps = 14/288 (4%)
Query: 120 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANV--NIQDAVFFTPLHIAAYY 177
LL +GAD G TA+H A G+ + ++LL+ N +++ + +PLH+AAY
Sbjct: 536 LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYN 595
Query: 178 GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHV 237
GH + + L + +++V G L LA+ +G ++L G+ A + + +
Sbjct: 596 GHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRK-WT 654
Query: 238 PLHFCSRFGHHDIVKYLLQSDLEVQ-PHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTE 296
PLH + GH D + L+ S V++ YG TPL LA NG + +++ T
Sbjct: 655 PLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTA 714
Query: 297 SLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLV 356
++ TA H G D + LLD + + + G T +H A GH ++
Sbjct: 715 DAA--DLRGRTALHRGAVTGCE-DCLAALLDHDAFVLCRDFK-GRTPIHLASACGHTAVL 770
Query: 357 QFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH-DAIVTLLKH 403
+ LL ++ DP + + + + WA GH D + LL+H
Sbjct: 771 RTLLQAA-----LSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH 813
Score = 87.4 bits (215), Expect = 5e-17
Identities = 90/328 (27%), Positives = 135/328 (41%), Gaps = 23/328 (7%)
Query: 73 LCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGY 132
+ I G + L+ KG G TALH + + +LL A + +
Sbjct: 693 MLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDF 752
Query: 133 GGLTALHIATIAGHLEAADVLLQHGANVNIQDAVF----FTPLHIAAYYGHEQVTRLLLK 188
G T +H+A+ GH LLQ + + DA ++P+H A+Y GHE LLL+
Sbjct: 753 KGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE 812
Query: 189 FGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHH 248
+ G PLH A + ++L+ VN++D + PLH + +
Sbjct: 813 HSPFSYLEGN-PFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNV 871
Query: 249 DIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETA 308
++ LLQ EV + + G T L A NG+ A E + G LT + TA
Sbjct: 872 SGLRMLLQHQAEV--NATDHTGRTALMTAAENGQ-TAAVEFLLYRGKADLTVLDENKNTA 928
Query: 309 FHSACTYGKSIDLVKFLLD-QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 367
H AC+ G + L + Q++ IN LH A +G +VQ LL +GA +
Sbjct: 929 LHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVL 988
Query: 368 LV---------ACDPSRSSGEKDEQTCL 386
V AC P+ KD CL
Sbjct: 989 AVDEEGHTPALACAPN-----KDVADCL 1011
Score = 84.0 bits (206), Expect = 5e-16
Identities = 77/279 (27%), Positives = 120/279 (43%), Gaps = 22/279 (7%)
Query: 101 GFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANV 160
G T L LA+ + + + LL G+ G TALH + G + LL H A V
Sbjct: 688 GQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFV 747
Query: 161 NIQDAVFFTPLHIAAYYGHEQVTRLLLK-------FGADVNVSGEVGDRPLHLASAKGFL 213
+D TP+H+A+ GH V R LL+ A V+ SG P+H AS G
Sbjct: 748 LCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGY---SPMHWASYTGHE 804
Query: 214 NIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVN---IYG 270
+ +LL+E + + + PLH C+ + D +L L + +VN G
Sbjct: 805 DCLELLLEH---SPFSYLEGNPFTPLH-CAVINNQDSTTEMLLGALGAK--IVNSRDAKG 858
Query: 271 DTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNV 330
TPLH A + + ++Q + T TA +A G++ V+FLL +
Sbjct: 859 RTPLHAAAFADNVSGLRMLLQHQAEVNATDHT--GRTALMTAAENGQTA-AVEFLLYRGK 915
Query: 331 ININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLV 369
++ + +T LH AC GH + +L D+ L+
Sbjct: 916 ADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLI 954
Score = 60.5 bits (145), Expect = 6e-09
Identities = 60/232 (25%), Positives = 94/232 (40%), Gaps = 50/232 (21%)
Query: 170 PLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVN 229
PL A + + R LL ++NV + PLH A+ G + I +LL+ G A+VN
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSG--ANVN 68
Query: 230 AQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEI 289
A+D PLH + + ++ LL +V + TPLH+A N + A+ +
Sbjct: 69 AKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNAR--DKLWQTPLHVAAANRATKCAEAL 126
Query: 290 IQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACY 349
+ + ++N R G + LH A +
Sbjct: 127 APL-------------------------------------LSSLNVADRSGRSALHHAVH 149
Query: 350 HGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
GH+ V LL+ GA +N+ CD K E+ L WA GH ++ LL
Sbjct: 150 SGHLETVNLLLNKGASLNV--CD-------KKERQPLHWAAFLGHLEVLKLL 192
>gi|62420875 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 134 bits (336), Expect = 5e-31
Identities = 123/514 (23%), Positives = 220/514 (42%), Gaps = 86/514 (16%)
Query: 215 IAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL 274
+A L + ++ D+N D+ PLH+ R G +V+ L+ + +V+N DTPL
Sbjct: 14 VAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI--NVMNRGDDTPL 71
Query: 275 HLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININ 334
HLA +G ++ ++++Q + D N +N
Sbjct: 72 HLAASHGHRDIVQKLLQ--------------------------------YKADINAVN-- 97
Query: 335 HQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 394
G+ LH AC+ G ++ + L+ NGA +++ GE
Sbjct: 98 ---EHGNVPLHYACFWGQDQVAEDLVANGALVSI-----CNKYGEMP------------- 136
Query: 395 DAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPS 454
+ K P EL + G + + + K + T+ + L
Sbjct: 137 ------VDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPR------NGTLNK 184
Query: 455 HFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILC 514
H + ++ F + G+++KGR + + +K + + ++ D F E L
Sbjct: 185 HSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRD-FNEECPRLR 243
Query: 515 QLNHPCVIQFVGACLNDPSQF-AIVTQYISGGSLFSLLHEQKRILDLQSKLI-IAVDVAK 572
+HP V+ +GAC + P+ ++T ++ GSL+++LHE + QS+ + A+D+A+
Sbjct: 244 IFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMAR 303
Query: 573 GMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNL---R 629
GM +LH L I LNS ++++ ED A ++ D + PG +
Sbjct: 304 GMAFLHTLEPLIPRHALNSRSVMIDEDMTARIS---------MADVKFSFQCPGRMYAPA 354
Query: 630 WMAPEVFTQCTRYTIK--ADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIG 687
W+APE + T + AD++S+A+ LWE++T E+PFA L +A +RP I
Sbjct: 355 WVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIP 414
Query: 688 YSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEE 721
I + L+ N P RP+F +V LE+
Sbjct: 415 PGISPHVCKLMKICMNEDPAKRPKFDMIVPILEK 448
Score = 67.4 bits (163), Expect = 5e-11
Identities = 34/99 (34%), Positives = 59/99 (59%), Gaps = 4/99 (4%)
Query: 192 DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIV 251
D+N + G PLH A +G + ++L+ G++ +N + D PLH + GH DIV
Sbjct: 26 DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGAR--INVMNRGDDTPLHLAASHGHRDIV 83
Query: 252 KYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEII 290
+ LLQ ++ + VN +G+ PLH AC+ G+ +VA++++
Sbjct: 84 QKLLQYKADI--NAVNEHGNVPLHYACFWGQDQVAEDLV 120
Score = 67.0 bits (162), Expect = 7e-11
Identities = 41/130 (31%), Positives = 66/130 (50%), Gaps = 4/130 (3%)
Query: 100 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 159
+GF+ LH A + + ++ L+ GA I + G T LH+A GH + LLQ+ A+
Sbjct: 33 HGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKAD 92
Query: 160 VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLL 219
+N + PLH A ++G +QV L+ GA V++ + G+ P+ A A + +LL
Sbjct: 93 INAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAP----LRELL 148
Query: 220 MEEGSKADVN 229
E K N
Sbjct: 149 RERAEKMGQN 158
Score = 65.1 bits (157), Expect = 3e-10
Identities = 34/103 (33%), Positives = 55/103 (53%)
Query: 126 DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRL 185
D+ Q G + LH A G ++L+ GA +N+ + TPLH+AA +GH + +
Sbjct: 26 DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQK 85
Query: 186 LLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADV 228
LL++ AD+N E G+ PLH A G +A+ L+ G+ +
Sbjct: 86 LLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSI 128
Score = 54.7 bits (130), Expect = 4e-07
Identities = 40/136 (29%), Positives = 65/136 (47%), Gaps = 1/136 (0%)
Query: 59 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 118
+LN ++G S LH C G+ + + L+++G R + + R T LHLA + +++
Sbjct: 26 DLNQGDDHGFSPLHWACR-EGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQ 84
Query: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
LL ADI V G LH A G + A+ L+ +GA V+I + P+ A
Sbjct: 85 KLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPL 144
Query: 179 HEQVTRLLLKFGADVN 194
E + K G ++N
Sbjct: 145 RELLRERAEKMGQNLN 160
>gi|62420873 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 134 bits (336), Expect = 5e-31
Identities = 123/514 (23%), Positives = 220/514 (42%), Gaps = 86/514 (16%)
Query: 215 IAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL 274
+A L + ++ D+N D+ PLH+ R G +V+ L+ + +V+N DTPL
Sbjct: 14 VAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI--NVMNRGDDTPL 71
Query: 275 HLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININ 334
HLA +G ++ ++++Q + D N +N
Sbjct: 72 HLAASHGHRDIVQKLLQ--------------------------------YKADINAVN-- 97
Query: 335 HQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 394
G+ LH AC+ G ++ + L+ NGA +++ GE
Sbjct: 98 ---EHGNVPLHYACFWGQDQVAEDLVANGALVSI-----CNKYGEMP------------- 136
Query: 395 DAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPS 454
+ K P EL + G + + + K + T+ + L
Sbjct: 137 ------VDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPR------NGTLNK 184
Query: 455 HFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILC 514
H + ++ F + G+++KGR + + +K + + ++ D F E L
Sbjct: 185 HSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRD-FNEECPRLR 243
Query: 515 QLNHPCVIQFVGACLNDPSQF-AIVTQYISGGSLFSLLHEQKRILDLQSKLI-IAVDVAK 572
+HP V+ +GAC + P+ ++T ++ GSL+++LHE + QS+ + A+D+A+
Sbjct: 244 IFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMAR 303
Query: 573 GMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNL---R 629
GM +LH L I LNS ++++ ED A ++ D + PG +
Sbjct: 304 GMAFLHTLEPLIPRHALNSRSVMIDEDMTARIS---------MADVKFSFQCPGRMYAPA 354
Query: 630 WMAPEVFTQCTRYTIK--ADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIG 687
W+APE + T + AD++S+A+ LWE++T E+PFA L +A +RP I
Sbjct: 355 WVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIP 414
Query: 688 YSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEE 721
I + L+ N P RP+F +V LE+
Sbjct: 415 PGISPHVCKLMKICMNEDPAKRPKFDMIVPILEK 448
Score = 67.4 bits (163), Expect = 5e-11
Identities = 34/99 (34%), Positives = 59/99 (59%), Gaps = 4/99 (4%)
Query: 192 DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIV 251
D+N + G PLH A +G + ++L+ G++ +N + D PLH + GH DIV
Sbjct: 26 DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGAR--INVMNRGDDTPLHLAASHGHRDIV 83
Query: 252 KYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEII 290
+ LLQ ++ + VN +G+ PLH AC+ G+ +VA++++
Sbjct: 84 QKLLQYKADI--NAVNEHGNVPLHYACFWGQDQVAEDLV 120
Score = 67.0 bits (162), Expect = 7e-11
Identities = 41/130 (31%), Positives = 66/130 (50%), Gaps = 4/130 (3%)
Query: 100 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 159
+GF+ LH A + + ++ L+ GA I + G T LH+A GH + LLQ+ A+
Sbjct: 33 HGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKAD 92
Query: 160 VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLL 219
+N + PLH A ++G +QV L+ GA V++ + G+ P+ A A + +LL
Sbjct: 93 INAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAP----LRELL 148
Query: 220 MEEGSKADVN 229
E K N
Sbjct: 149 RERAEKMGQN 158
Score = 65.1 bits (157), Expect = 3e-10
Identities = 34/103 (33%), Positives = 55/103 (53%)
Query: 126 DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRL 185
D+ Q G + LH A G ++L+ GA +N+ + TPLH+AA +GH + +
Sbjct: 26 DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQK 85
Query: 186 LLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADV 228
LL++ AD+N E G+ PLH A G +A+ L+ G+ +
Sbjct: 86 LLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSI 128
Score = 54.7 bits (130), Expect = 4e-07
Identities = 40/136 (29%), Positives = 65/136 (47%), Gaps = 1/136 (0%)
Query: 59 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 118
+LN ++G S LH C G+ + + L+++G R + + R T LHLA + +++
Sbjct: 26 DLNQGDDHGFSPLHWACR-EGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQ 84
Query: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
LL ADI V G LH A G + A+ L+ +GA V+I + P+ A
Sbjct: 85 KLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPL 144
Query: 179 HEQVTRLLLKFGADVN 194
E + K G ++N
Sbjct: 145 RELLRERAEKMGQNLN 160
>gi|4758606 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 134 bits (336), Expect = 5e-31
Identities = 123/514 (23%), Positives = 220/514 (42%), Gaps = 86/514 (16%)
Query: 215 IAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL 274
+A L + ++ D+N D+ PLH+ R G +V+ L+ + +V+N DTPL
Sbjct: 14 VAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI--NVMNRGDDTPL 71
Query: 275 HLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININ 334
HLA +G ++ ++++Q + D N +N
Sbjct: 72 HLAASHGHRDIVQKLLQ--------------------------------YKADINAVN-- 97
Query: 335 HQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 394
G+ LH AC+ G ++ + L+ NGA +++ GE
Sbjct: 98 ---EHGNVPLHYACFWGQDQVAEDLVANGALVSI-----CNKYGEMP------------- 136
Query: 395 DAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPS 454
+ K P EL + G + + + K + T+ + L
Sbjct: 137 ------VDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPR------NGTLNK 184
Query: 455 HFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILC 514
H + ++ F + G+++KGR + + +K + + ++ D F E L
Sbjct: 185 HSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRD-FNEECPRLR 243
Query: 515 QLNHPCVIQFVGACLNDPSQF-AIVTQYISGGSLFSLLHEQKRILDLQSKLI-IAVDVAK 572
+HP V+ +GAC + P+ ++T ++ GSL+++LHE + QS+ + A+D+A+
Sbjct: 244 IFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMAR 303
Query: 573 GMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNL---R 629
GM +LH L I LNS ++++ ED A ++ D + PG +
Sbjct: 304 GMAFLHTLEPLIPRHALNSRSVMIDEDMTARIS---------MADVKFSFQCPGRMYAPA 354
Query: 630 WMAPEVFTQCTRYTIK--ADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIG 687
W+APE + T + AD++S+A+ LWE++T E+PFA L +A +RP I
Sbjct: 355 WVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIP 414
Query: 688 YSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEE 721
I + L+ N P RP+F +V LE+
Sbjct: 415 PGISPHVCKLMKICMNEDPAKRPKFDMIVPILEK 448
Score = 67.4 bits (163), Expect = 5e-11
Identities = 34/99 (34%), Positives = 59/99 (59%), Gaps = 4/99 (4%)
Query: 192 DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIV 251
D+N + G PLH A +G + ++L+ G++ +N + D PLH + GH DIV
Sbjct: 26 DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGAR--INVMNRGDDTPLHLAASHGHRDIV 83
Query: 252 KYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEII 290
+ LLQ ++ + VN +G+ PLH AC+ G+ +VA++++
Sbjct: 84 QKLLQYKADI--NAVNEHGNVPLHYACFWGQDQVAEDLV 120
Score = 67.0 bits (162), Expect = 7e-11
Identities = 41/130 (31%), Positives = 66/130 (50%), Gaps = 4/130 (3%)
Query: 100 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 159
+GF+ LH A + + ++ L+ GA I + G T LH+A GH + LLQ+ A+
Sbjct: 33 HGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKAD 92
Query: 160 VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLL 219
+N + PLH A ++G +QV L+ GA V++ + G+ P+ A A + +LL
Sbjct: 93 INAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAP----LRELL 148
Query: 220 MEEGSKADVN 229
E K N
Sbjct: 149 RERAEKMGQN 158
Score = 65.1 bits (157), Expect = 3e-10
Identities = 34/103 (33%), Positives = 55/103 (53%)
Query: 126 DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRL 185
D+ Q G + LH A G ++L+ GA +N+ + TPLH+AA +GH + +
Sbjct: 26 DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQK 85
Query: 186 LLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADV 228
LL++ AD+N E G+ PLH A G +A+ L+ G+ +
Sbjct: 86 LLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSI 128
Score = 54.7 bits (130), Expect = 4e-07
Identities = 40/136 (29%), Positives = 65/136 (47%), Gaps = 1/136 (0%)
Query: 59 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 118
+LN ++G S LH C G+ + + L+++G R + + R T LHLA + +++
Sbjct: 26 DLNQGDDHGFSPLHWACR-EGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQ 84
Query: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
LL ADI V G LH A G + A+ L+ +GA V+I + P+ A
Sbjct: 85 KLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPL 144
Query: 179 HEQVTRLLLKFGADVN 194
E + K G ++N
Sbjct: 145 RELLRERAEKMGQNLN 160
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 131 bits (330), Expect = 2e-30
Identities = 116/363 (31%), Positives = 167/363 (46%), Gaps = 26/363 (7%)
Query: 69 SLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQ 128
S L L C G +R L+ G T TAL A + E+ LL SGA +
Sbjct: 374 SALTLACY-KGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 432
Query: 129 QVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLK 188
+ L +A GH+E A +L++ GAN+ + +TPL AA GHE++ LLL
Sbjct: 433 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 492
Query: 189 FGADVNV-SGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGH 247
GA++N + E + L LA GF +A L++ G+ ++ PL S+ GH
Sbjct: 493 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS-----TPLMEASQEGH 547
Query: 248 HDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSET 307
++VKYLL S V H GDT L AC NG +VA ++Q L E+ T
Sbjct: 548 LELVKYLLASGANV--HATTATGDTALTYACENGHTDVADVLLQAGA--DLEHESEGGRT 603
Query: 308 AFHSACTYGKSIDLVKFLLDQNVININH-QGRDGHTGLHSACYHGHIRLVQFLLDNGADM 366
A G + V+FL+ + N+N + HT + AC GH+ +V+ LL +GA
Sbjct: 604 PLMKAARAG-HLCTVQFLISKGA-NVNRATANNDHTVVSLACAGGHLAVVELLLAHGA-- 659
Query: 367 NLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQ---PGGDG 423
DP+ KD T L+ A + GH +V+ L Y +P + SQ P D
Sbjct: 660 -----DPTHRL--KDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQ 712
Query: 424 SYV 426
S V
Sbjct: 713 SQV 715
Score = 111 bits (277), Expect = 3e-24
Identities = 106/370 (28%), Positives = 168/370 (45%), Gaps = 26/370 (7%)
Query: 55 FSKVNLNYRTE-NGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDN 113
+ V+++ TE N + L L C GG + + L+ + + + GFT L LA +
Sbjct: 1042 YPSVDIDAHTESNHDTALTLAC-AGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGH 1100
Query: 114 AELITSLLHSGADIQ-QVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLH 172
++ LL G DI+ Q T L +A G E D+LL GAN ++ +TPL
Sbjct: 1101 VGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLS 1160
Query: 173 IAAYYGHEQVTRLLLKFGADVN--VSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNA 230
+AA G+ + ++LL GA++N ++G PL LA+ G + KLL++ GS D+NA
Sbjct: 1161 LAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS--DINA 1218
Query: 231 Q-DNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEI 289
Q + + L G ++V LL V+ G TPL A G EV + +
Sbjct: 1219 QIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKT--GLTPLMEAASGGYAEVGRVL 1276
Query: 290 IQISGTESLTKENIFSETAFHSACTYGKSIDLVKF--LLDQNVININHQGRDGHTGLHSA 347
+ + +TA A G KF LL +I+ + + G+T L A
Sbjct: 1277 LDKGADVNAPPVPSSRDTALTIAADKGH----YKFCELLIHRGAHIDVRNKKGNTPLWLA 1332
Query: 348 CYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVT-LLKHYKR 406
GH +VQ L+ GAD++ + + + T LM A+ KGH +V L+K +
Sbjct: 1333 SNGGHFDVVQLLVQAGADVD---------AADNRKITPLMSAFRKGHVKVVQYLVKEVNQ 1383
Query: 407 PQDELPCNEY 416
++ C Y
Sbjct: 1384 FPSDIECMRY 1393
Score = 107 bits (267), Expect = 5e-23
Identities = 92/325 (28%), Positives = 153/325 (47%), Gaps = 18/325 (5%)
Query: 79 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGY-GGLTA 137
G + +R L+ +G + T G + L LA EL LL A+++ G G +T
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
Query: 138 LHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSG 197
L A+ G+L+ +LL H A+VN Q A T L A G + ++LL GA++
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 198 EVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNE-DHVPLHFCSRFGHHDIVKYLLQ 256
E G PL A++ G + +A++L++ G A +N NE L GH D+V++LL+
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHG--AGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 257 SDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYG 316
+ + + ++ T L AC +G EVA+ ++ SG + + F +AC G
Sbjct: 394 AGADQEHKTDEMH--TALMEACMDGHVEVARLLLD-SGAQVNMPADSFESPLTLAAC--G 448
Query: 317 KSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRS 376
++L L+++ N+ +G+T L A GH +V LL GA++N +
Sbjct: 449 GHVELAALLIERGA-NLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN--------A 499
Query: 377 SGEKDEQTCLMWAYEKGHDAIVTLL 401
E+ ++T L A G + L
Sbjct: 500 QTEETQETALTLACCGGFSEVADFL 524
Score = 69.7 bits (169), Expect = 1e-11
Identities = 78/298 (26%), Positives = 129/298 (43%), Gaps = 28/298 (9%)
Query: 109 VYKDNAELITSLLHSGADIQQVG---YGGLTALHIATIAGHLEAADVLLQHGANVNIQDA 165
V K +E+ S GAD++ V L AL A G L AD D
Sbjct: 117 VLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTAD-------GKAFADP 169
Query: 166 VFFTPLHIAAYYGHEQVTRLLLKFGAD-VNVSGEVGDRPLHLASAKGFLNIAKLLMEEGS 224
L + ++ L + A+ + +G+V R L A + G +N + L++EG
Sbjct: 170 EVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGR 229
Query: 225 KADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGD-TPLHLACYNGKF 283
+ + ++ E + L CS G++++ + LL V+ GD TPL A G
Sbjct: 230 SVNEHTEEGESLLCL-ACSA-GYYELAQVLLAMHANVEDR--GNKGDITPLMAASSGGYL 285
Query: 284 EVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTG 343
++ K + + + ++ TA AC G +D+VK LL++ NI +GHT
Sbjct: 286 DIVK--LLLLHDADVNSQSATGNTALTYACA-GGFVDIVKVLLNEGA-NIEDHNENGHTP 341
Query: 344 LHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
L A GH+ + + LLD+GA +N + + +++ L A KGH +V L
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGIN--------THSNEFKESALTLACYKGHLDMVRFL 391
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 131 bits (330), Expect = 2e-30
Identities = 116/363 (31%), Positives = 167/363 (46%), Gaps = 26/363 (7%)
Query: 69 SLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQ 128
S L L C G +R L+ G T TAL A + E+ LL SGA +
Sbjct: 374 SALTLACY-KGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 432
Query: 129 QVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLK 188
+ L +A GH+E A +L++ GAN+ + +TPL AA GHE++ LLL
Sbjct: 433 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 492
Query: 189 FGADVNV-SGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGH 247
GA++N + E + L LA GF +A L++ G+ ++ PL S+ GH
Sbjct: 493 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS-----TPLMEASQEGH 547
Query: 248 HDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSET 307
++VKYLL S V H GDT L AC NG +VA ++Q L E+ T
Sbjct: 548 LELVKYLLASGANV--HATTATGDTALTYACENGHTDVADVLLQAGA--DLEHESEGGRT 603
Query: 308 AFHSACTYGKSIDLVKFLLDQNVININH-QGRDGHTGLHSACYHGHIRLVQFLLDNGADM 366
A G + V+FL+ + N+N + HT + AC GH+ +V+ LL +GA
Sbjct: 604 PLMKAARAG-HLCTVQFLISKGA-NVNRATANNDHTVVSLACAGGHLAVVELLLAHGA-- 659
Query: 367 NLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQ---PGGDG 423
DP+ KD T L+ A + GH +V+ L Y +P + SQ P D
Sbjct: 660 -----DPTHRL--KDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQ 712
Query: 424 SYV 426
S V
Sbjct: 713 SQV 715
Score = 111 bits (277), Expect = 3e-24
Identities = 106/370 (28%), Positives = 168/370 (45%), Gaps = 26/370 (7%)
Query: 55 FSKVNLNYRTE-NGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDN 113
+ V+++ TE N + L L C GG + + L+ + + + GFT L LA +
Sbjct: 1042 YPSVDIDAHTESNHDTALTLAC-AGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGH 1100
Query: 114 AELITSLLHSGADIQ-QVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLH 172
++ LL G DI+ Q T L +A G E D+LL GAN ++ +TPL
Sbjct: 1101 VGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLS 1160
Query: 173 IAAYYGHEQVTRLLLKFGADVN--VSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNA 230
+AA G+ + ++LL GA++N ++G PL LA+ G + KLL++ GS D+NA
Sbjct: 1161 LAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS--DINA 1218
Query: 231 Q-DNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEI 289
Q + + L G ++V LL V+ G TPL A G EV + +
Sbjct: 1219 QIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKT--GLTPLMEAASGGYAEVGRVL 1276
Query: 290 IQISGTESLTKENIFSETAFHSACTYGKSIDLVKF--LLDQNVININHQGRDGHTGLHSA 347
+ + +TA A G KF LL +I+ + + G+T L A
Sbjct: 1277 LDKGADVNAPPVPSSRDTALTIAADKGH----YKFCELLIHRGAHIDVRNKKGNTPLWLA 1332
Query: 348 CYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVT-LLKHYKR 406
GH +VQ L+ GAD++ + + + T LM A+ KGH +V L+K +
Sbjct: 1333 SNGGHFDVVQLLVQAGADVD---------AADNRKITPLMSAFRKGHVKVVQYLVKEVNQ 1383
Query: 407 PQDELPCNEY 416
++ C Y
Sbjct: 1384 FPSDIECMRY 1393
Score = 107 bits (267), Expect = 5e-23
Identities = 92/325 (28%), Positives = 153/325 (47%), Gaps = 18/325 (5%)
Query: 79 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGY-GGLTA 137
G + +R L+ +G + T G + L LA EL LL A+++ G G +T
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
Query: 138 LHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSG 197
L A+ G+L+ +LL H A+VN Q A T L A G + ++LL GA++
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 198 EVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNE-DHVPLHFCSRFGHHDIVKYLLQ 256
E G PL A++ G + +A++L++ G A +N NE L GH D+V++LL+
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHG--AGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 257 SDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYG 316
+ + + ++ T L AC +G EVA+ ++ SG + + F +AC G
Sbjct: 394 AGADQEHKTDEMH--TALMEACMDGHVEVARLLLD-SGAQVNMPADSFESPLTLAAC--G 448
Query: 317 KSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRS 376
++L L+++ N+ +G+T L A GH +V LL GA++N +
Sbjct: 449 GHVELAALLIERGA-NLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN--------A 499
Query: 377 SGEKDEQTCLMWAYEKGHDAIVTLL 401
E+ ++T L A G + L
Sbjct: 500 QTEETQETALTLACCGGFSEVADFL 524
Score = 69.7 bits (169), Expect = 1e-11
Identities = 78/298 (26%), Positives = 129/298 (43%), Gaps = 28/298 (9%)
Query: 109 VYKDNAELITSLLHSGADIQQVG---YGGLTALHIATIAGHLEAADVLLQHGANVNIQDA 165
V K +E+ S GAD++ V L AL A G L AD D
Sbjct: 117 VLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTAD-------GKAFADP 169
Query: 166 VFFTPLHIAAYYGHEQVTRLLLKFGAD-VNVSGEVGDRPLHLASAKGFLNIAKLLMEEGS 224
L + ++ L + A+ + +G+V R L A + G +N + L++EG
Sbjct: 170 EVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGR 229
Query: 225 KADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGD-TPLHLACYNGKF 283
+ + ++ E + L CS G++++ + LL V+ GD TPL A G
Sbjct: 230 SVNEHTEEGESLLCL-ACSA-GYYELAQVLLAMHANVEDR--GNKGDITPLMAASSGGYL 285
Query: 284 EVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTG 343
++ K + + + ++ TA AC G +D+VK LL++ NI +GHT
Sbjct: 286 DIVK--LLLLHDADVNSQSATGNTALTYACA-GGFVDIVKVLLNEGA-NIEDHNENGHTP 341
Query: 344 LHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
L A GH+ + + LLD+GA +N + + +++ L A KGH +V L
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGIN--------THSNEFKESALTLACYKGHLDMVRFL 391
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 131 bits (329), Expect = 3e-30
Identities = 98/360 (27%), Positives = 171/360 (47%), Gaps = 22/360 (6%)
Query: 60 LNYRTENGLSLLHLCCIC----GGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAE 115
+N+ +G + L + +C G S + L+ +G ++G T L +A Y+ + +
Sbjct: 703 VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVD 762
Query: 116 LITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 175
++ LL GAD+ G T L A GH + LL GA V+ D+ T L IA+
Sbjct: 763 VVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIAS 822
Query: 176 YYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 235
G+ +V R LL G D N + G PLH+A+ +G I + L+E+G++ N DN+
Sbjct: 823 AQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGAR--TNEIDNDG 880
Query: 236 HVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGT 295
+P S+ GH+D V+ LL++ + + G L +A G ++ E++ G
Sbjct: 881 RIPFILASQEGHYDCVQILLENKSNIDQRGYD--GRNALRVAALEGHRDIV-ELLFSHGA 937
Query: 296 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 355
+ K+ T + A + + ++ L +N N+ +G T LH +C+ GH+ +
Sbjct: 938 DVNCKDADGRPTLYILALE--NQLTMAEYFL-ENGANVEASDAEGRTALHVSCWQGHMEM 994
Query: 356 VQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNE 415
VQ L+ AD+N + + ++++ L A +GH +V LL + D CN+
Sbjct: 995 VQVLIAYHADVN---------AADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDH-TCNQ 1044
Score = 123 bits (308), Expect = 8e-28
Identities = 93/346 (26%), Positives = 160/346 (46%), Gaps = 18/346 (5%)
Query: 59 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 118
++++ NG + L L G S + TL+ G + G T L +A + N E++
Sbjct: 773 DVDHTDNNGRTPL-LAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVR 831
Query: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
+LL G D G T LH+A GH + L++ GA N D P +A+ G
Sbjct: 832 TLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEG 891
Query: 179 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238
H ++LL+ ++++ G G L +A+ +G +I +LL G ADVN +D +
Sbjct: 892 HYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHG--ADVNCKDADGRPT 949
Query: 239 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESL 298
L+ + + +Y L++ V+ + G T LH++C+ G E+ + +I +
Sbjct: 950 LYILALENQLTMAEYFLENGANVEAS--DAEGRTALHVSCWQGHMEMVQVLIAYHADVNA 1007
Query: 299 TKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQF 358
+A SA G + +V+ L++ + ++H G T L A GHI +VQ
Sbjct: 1008 ADNE--KRSALQSAAWQGH-VKVVQLLIEHGAV-VDHTCNQGATALCIAAQEGHIDVVQV 1063
Query: 359 LLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHY 404
LL++GAD N ++ +T + A + GH I+ LL+ Y
Sbjct: 1064 LLEHGADPN---------HADQFGRTAMRVAAKNGHSQIIKLLEKY 1100
Score = 113 bits (282), Expect = 8e-25
Identities = 92/304 (30%), Positives = 145/304 (47%), Gaps = 20/304 (6%)
Query: 112 DNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPL 171
+ + I +LL +GA + Q G T L A +G L+ ++L+ GA++ I+DA TPL
Sbjct: 523 EREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPL 582
Query: 172 HIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQ 231
+AA GH +V L+ GA++N + + G L A+ G + L+ G K D
Sbjct: 583 TLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVD--CA 640
Query: 232 DNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQ 291
D + L + GH DIV LLQ EV + + G T L A Y G E+ + ++
Sbjct: 641 DADSRTALRAAAWGGHEDIVLNLLQHGAEV--NKADNEGRTALIAAAYMGHREIVEHLLD 698
Query: 292 ISGTESLTKENIFSETAFHSA--CTYGKS--IDLVKFLLDQNVININHQGRDGHTGLHSA 347
G E + E++ TA A C +V L+D+ ++H +DG T L A
Sbjct: 699 -HGAE-VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGA-EVDHCDKDGMTPLLVA 755
Query: 348 CYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRP 407
Y GH+ +V LL+ GAD+ D + ++G +T L+ A GH ++V L +
Sbjct: 756 AYEGHVDVVDLLLEGGADV-----DHTDNNG----RTPLLAAASMGHASVVNTLLFWGAA 806
Query: 408 QDEL 411
D +
Sbjct: 807 VDSI 810
Score = 105 bits (261), Expect = 2e-22
Identities = 80/296 (27%), Positives = 139/296 (46%), Gaps = 9/296 (3%)
Query: 79 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 138
G +RTL+ +GL + G+T LH+A ++ + + +L+ GA ++ G
Sbjct: 825 GNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPF 884
Query: 139 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGE 198
+A+ GH + +LL++ +N++ + L +AA GH + LL GADVN
Sbjct: 885 ILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDA 944
Query: 199 VGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSD 258
G L++ + + L +A+ +E G A+V A D E LH GH ++V+ L+
Sbjct: 945 DGRPTLYILALENQLTMAEYFLENG--ANVEASDAEGRTALHVSCWQGHMEMVQVLIAYH 1002
Query: 259 LEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKS 318
+V + + + L A + G +V + +I+ T TA A G
Sbjct: 1003 ADV--NAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQ--GATALCIAAQEGH- 1057
Query: 319 IDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPS 374
ID+V+ LL+ + NH + G T + A +GH ++++ L GA +L C PS
Sbjct: 1058 IDVVQVLLEHGA-DPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS-SLNGCSPS 1111
Score = 103 bits (258), Expect = 5e-22
Identities = 101/387 (26%), Positives = 163/387 (42%), Gaps = 50/387 (12%)
Query: 59 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 118
++N NG +LL G + L+ +G +G T L LA + + +++
Sbjct: 537 SVNQCDSNGRTLLANAAY-SGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVN 595
Query: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 178
L+ GA+I G TAL A GH E LL G V+ DA T L AA+ G
Sbjct: 596 CLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGG 655
Query: 179 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238
HE + LL+ GA+VN + G L A+ G I + L++ G A+VN +D +
Sbjct: 656 HEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG--AEVNHEDVDGRTA 713
Query: 239 LHFC-----SRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQ-- 291
L + GH +V L+ EV + G TPL +A Y G +V +++
Sbjct: 714 LSVAALCVPASKGHASVVSLLIDRGAEVDH--CDKDGMTPLLVAAYEGHVDVVDLLLEGG 771
Query: 292 ------------------ISGTESLTKENIFSETAFHSACTYGK----------SIDLVK 323
G S+ +F A S + G+ ++++V+
Sbjct: 772 ADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVR 831
Query: 324 FLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQ 383
LLD+ ++ NH+ G T LH A + GH + + L++ GA N + + D +
Sbjct: 832 TLLDRG-LDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEI---------DNDGR 881
Query: 384 TCLMWAYEKGHDAIVTLLKHYKRPQDE 410
+ A ++GH V +L K D+
Sbjct: 882 IPFILASQEGHYDCVQILLENKSNIDQ 908
Score = 84.3 bits (207), Expect = 4e-16
Identities = 54/199 (27%), Positives = 101/199 (50%), Gaps = 3/199 (1%)
Query: 56 SKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAE 115
+K N++ R +G + L + + G + + L G + +G L++ ++
Sbjct: 902 NKSNIDQRGYDGRNALRVAAL-EGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLT 960
Query: 116 LITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 175
+ L +GA+++ G TALH++ GH+E VL+ + A+VN D + L AA
Sbjct: 961 MAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAA 1020
Query: 176 YYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 235
+ GH +V +LL++ GA V+ + G L +A+ +G +++ ++L+E G AD N D
Sbjct: 1021 WQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG--ADPNHADQFG 1078
Query: 236 HVPLHFCSRFGHHDIVKYL 254
+ ++ GH I+K L
Sbjct: 1079 RTAMRVAAKNGHSQIIKLL 1097
Score = 65.1 bits (157), Expect = 3e-10
Identities = 47/161 (29%), Positives = 74/161 (45%), Gaps = 13/161 (8%)
Query: 31 LEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLK 90
LE+ L + E L N+ SD G + LH+ C G ++ L+
Sbjct: 955 LENQLTMAEYFLENGANVEASDA------------EGRTALHVSC-WQGHMEMVQVLIAY 1001
Query: 91 GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAA 150
+ +AL A ++ + +++ L+ GA + G TAL IA GH++
Sbjct: 1002 HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVV 1061
Query: 151 DVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA 191
VLL+HGA+ N D T + +AA GH Q+ +LL K+GA
Sbjct: 1062 QVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,587,569
Number of Sequences: 37866
Number of extensions: 1521260
Number of successful extensions: 11554
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 753
Number of HSP's successfully gapped in prelim test: 369
Number of HSP's that attempted gapping in prelim test: 3903
Number of HSP's gapped (non-prelim): 3205
length of query: 835
length of database: 18,247,518
effective HSP length: 111
effective length of query: 724
effective length of database: 14,044,392
effective search space: 10168139808
effective search space used: 10168139808
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.