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Search of human proteins with 14042978
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14042978 BRCA1 interacting protein C-terminal helicase 1
[Homo sapiens]
(1249 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14042978 BRCA1 interacting protein C-terminal helicase 1 [Hom... 2525 0.0
gi|212549538 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12 [Ho... 271 4e-72
gi|100913202 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 iso... 270 5e-72
gi|132566527 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 iso... 231 4e-60
gi|91984775 regulator of telomere elongation helicase 1 isoform ... 218 3e-56
gi|7706541 regulator of telomere elongation helicase 1 isoform 1... 218 3e-56
gi|100913204 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 iso... 211 3e-54
gi|15834617 excision repair cross-complementing rodent repair de... 171 4e-42
gi|239755744 PREDICTED: similar to Putative ATP-dependent RNA he... 135 2e-31
gi|195947407 excision repair cross-complementing rodent repair d... 71 6e-12
gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens] 37 0.12
gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens] 36 0.26
gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens] 36 0.26
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 36 0.26
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 35 0.45
gi|52694665 zinc finger and BTB domain containing 20 [Homo sapiens] 35 0.45
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 35 0.45
gi|145553976 zinc finger, CW type with coiled-coil domain 2 isof... 35 0.45
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 35 0.58
gi|122891870 melanoma inhibitory activity family, member 3 [Homo... 34 1.00
gi|91982772 mucin 17 [Homo sapiens] 34 1.00
gi|193788732 calcium channel, voltage-dependent, L type, alpha 1... 33 1.3
gi|193788728 calcium channel, voltage-dependent, L type, alpha 1... 33 1.3
gi|193788724 calcium channel, voltage-dependent, L type, alpha 1... 33 1.3
gi|120433602 calcium channel, voltage-dependent, L type, alpha 1... 33 1.3
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1... 33 1.3
gi|193788544 calcium channel, voltage-dependent, L type, alpha 1... 33 1.3
gi|193788542 calcium channel, voltage-dependent, L type, alpha 1... 33 1.3
gi|193788540 calcium channel, voltage-dependent, L type, alpha 1... 33 1.3
gi|193788538 calcium channel, voltage-dependent, L type, alpha 1... 33 1.3
>gi|14042978 BRCA1 interacting protein C-terminal helicase 1 [Homo
sapiens]
Length = 1249
Score = 2525 bits (6545), Expect = 0.0
Identities = 1249/1249 (100%), Positives = 1249/1249 (100%)
Query: 1 MSSMWSEYTIGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSA 60
MSSMWSEYTIGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSA
Sbjct: 1 MSSMWSEYTIGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSA 60
Query: 61 LAWQQSLSGKPADEGVSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPSTPPSERNG 120
LAWQQSLSGKPADEGVSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPSTPPSERNG
Sbjct: 61 LAWQQSLSGKPADEGVSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPSTPPSERNG 120
Query: 121 TSSTCQDSPEKTTLAAKLSAKKQASIYRDENDDFQVEKKRIRPLETTQQIRKRHCFGTEV 180
TSSTCQDSPEKTTLAAKLSAKKQASIYRDENDDFQVEKKRIRPLETTQQIRKRHCFGTEV
Sbjct: 121 TSSTCQDSPEKTTLAAKLSAKKQASIYRDENDDFQVEKKRIRPLETTQQIRKRHCFGTEV 180
Query: 181 HNLDAKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGK 240
HNLDAKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGK
Sbjct: 181 HNLDAKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGK 240
Query: 241 SKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCME 300
SKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCME
Sbjct: 241 SKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCME 300
Query: 301 LLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQ 360
LLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQ
Sbjct: 301 LLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQ 360
Query: 361 DADIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARD 420
DADIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARD
Sbjct: 361 DADIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARD 420
Query: 421 ELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKIWSGNEMLLTLHKM 480
ELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKIWSGNEMLLTLHKM
Sbjct: 421 ELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKIWSGNEMLLTLHKM 480
Query: 481 GITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQ 540
GITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQ
Sbjct: 481 GITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQ 540
Query: 541 NSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAF 600
NSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAF
Sbjct: 541 NSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAF 600
Query: 601 SDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNL 660
SDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNL
Sbjct: 601 SDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNL 660
Query: 661 CATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELV 720
CATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELV
Sbjct: 661 CATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELV 720
Query: 721 KTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVI 780
KTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVI
Sbjct: 721 KTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVI 780
Query: 781 TIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWG 840
TIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWG
Sbjct: 781 TIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWG 840
Query: 841 ALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRT 900
ALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRT
Sbjct: 841 ALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRT 900
Query: 901 NIQDNESTLEVTSLKYSTPPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPS 960
NIQDNESTLEVTSLKYSTPPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPS
Sbjct: 901 NIQDNESTLEVTSLKYSTPPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPS 960
Query: 961 SIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKAT 1020
SIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKAT
Sbjct: 961 SIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKAT 1020
Query: 1021 PELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKID 1080
PELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKID
Sbjct: 1021 PELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKID 1080
Query: 1081 ATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPE 1140
ATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPE
Sbjct: 1081 ATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPE 1140
Query: 1141 DTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILH 1200
DTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILH
Sbjct: 1141 DTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILH 1200
Query: 1201 IEESKIDDIDGNVKTTWINELELGKTHEIEIKNFKPSPSKNKGMFPGFK 1249
IEESKIDDIDGNVKTTWINELELGKTHEIEIKNFKPSPSKNKGMFPGFK
Sbjct: 1201 IEESKIDDIDGNVKTTWINELELGKTHEIEIKNFKPSPSKNKGMFPGFK 1249
>gi|212549538 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12 [Homo
sapiens]
Length = 906
Score = 271 bits (692), Expect = 4e-72
Identities = 235/939 (25%), Positives = 432/939 (46%), Gaps = 106/939 (11%)
Query: 10 IGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSG 69
+G + FP+ Y Q M + R L + + + ESPTG+GKSL+L+C AL+W +
Sbjct: 8 VGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQ 67
Query: 70 KPADEG----------VSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPSTPPSERN 119
K +E + ++ + L +C GT R P E
Sbjct: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGA--------AGTPR-------PAGEPA 112
Query: 120 GTSSTCQDSPEKTTLAAKLSAKKQASIYRDENDDFQVEKKRIRPLETTQQIRKRHCFGTE 179
+ Q E+ L +L A++ R+E Q + R++ +++R+
Sbjct: 113 WVTQFVQKKEERD-LVNRLKAEQARRKQREER--LQQLQHRVQLKYAAKRLRQEEEEREN 169
Query: 180 VHNLDAKV-DSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHT 238
+ L ++ ++G + LE G + ++ ++ + +D
Sbjct: 170 LLRLSREMLETGPEAERPEQLES----------GEEELVLAEYESDEEKKVASGVDEDED 219
Query: 239 G--KSKIPKIYFGTRTHKQIAQITRELRRTAYS-GVPMTILSSRDHTCVHPEV--VGNFN 293
+ I KIY +RTH Q+AQ E++++ + V + L SR + CV+ +V +G+
Sbjct: 220 DLEEEHITKIYHCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVRSLGSVQ 279
Query: 294 R-NEKCMELLDGKNGK------------------SCYFYHGVHKISDQHTLQTFQGMCKA 334
N +C+++ ++ K +C FY+ +Q L + + +
Sbjct: 280 LINNRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYN-----HEQMGLLRDEALAEV 334
Query: 335 WDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQVVILDE 394
D+E+L++LGK+ +ACPYY +R I A ++ PY LL A R++ + L++QVVI+DE
Sbjct: 335 KDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDE 394
Query: 395 AHNIEDCARESASYSVTEVQLRFARDELDSMVNN---NIRKKDHEPLRAVCCSLINWLEA 451
AHN+ D S V+ QL A +L + ++ K+ L+ + L ++
Sbjct: 395 AHNLIDTTTSMHSVEVSGSQLCQAHSQLLQYMERYGKRLKAKNLMYLKQILYLLEKFVAV 454
Query: 452 NAEYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKE 511
+ + + +G E L T++ + I +K ++G
Sbjct: 455 LGGNIKQNPNTQSLS-QTGME-LKTINDFLFQSQIDNINLFKVQRYCEKSMISRKLFGFT 512
Query: 512 EAREVPVISASTQIMLKGLFMVLDYLFRQNSRF----ADDYKIAIQQTYSWTNQID---- 563
E R V S+ Q L G L L + + AD+ + ++ Q S I+
Sbjct: 513 E-RYGAVFSSREQPKLAGFQQFLQSLQPRTTEALAAPADESQASVPQPASPLMHIEGFLA 571
Query: 564 ---ISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPM 620
++++G ++L + S+ L F LNPAV F+ + + + +V+ GT+ P+
Sbjct: 572 ALTTANQDGRVILSRQGSLSQS-----TLKFLLLNPAVHFAQVVKECRAVVIAGGTMQPV 626
Query: 621 KSFSSEL----GVTF--TIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQD 674
+F +L GV ++ H+I + I SG + L TFQ + + D
Sbjct: 627 SNFRQQLLACAGVEAERVVEFSCGHVIPPDNILPLVICSGVSNQPLEFTFQKRDLPQMMD 686
Query: 675 EVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTN 734
EVG +L ++C VS G++CF PSY+ L ++ W GL L K + EP+ +
Sbjct: 687 EVGRILCNLCGVVSGGVVCFFPSYEYLRQVHAHWEKGGLLGRLAARKKIFQEPKSAHQV- 745
Query: 735 FDELLQVYYDAIKYKGEK----DGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVK 790
+++L Y ++ G++ GALL++V GK+SEG++FSD+ R V+ +G+PFPN++
Sbjct: 746 -EQVLLAYSRCLQACGQERGPVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIR 804
Query: 791 DLQVELKRQYNDHH-SKLRGLL-PGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDR 848
+++ K Y D + G PG+ E +A+NQ++GR IRH+ D+ +++L+D R
Sbjct: 805 SAELQEKMAYLDQTLPRAPGQAHPGKALVENLCMKAVNQSIGRAIRHQKDFASIVLLDQR 864
Query: 849 FRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKK 887
+ P ++ L W+R +++ +TF A+ ++ +F ++
Sbjct: 865 YARPP--VLAKLPAWIRARVEVKATFGPAIAAVQKFHRE 901
>gi|100913202 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
isoform 1 [Homo sapiens]
Length = 906
Score = 270 bits (691), Expect = 5e-72
Identities = 235/937 (25%), Positives = 431/937 (45%), Gaps = 102/937 (10%)
Query: 10 IGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSG 69
+G + FP+ Y Q M + R L + + + ESPTG+GKSL+L+C AL+W +
Sbjct: 8 VGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQ 67
Query: 70 KPADEG----------VSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPSTPPSERN 119
K +E + ++ + L +C GT R P E
Sbjct: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGA--------AGTPR-------PAGEPA 112
Query: 120 GTSSTCQDSPEKTTLAAKLSAKKQASIYRDENDDFQVEKKRIRPLETTQQIRKRHCFGTE 179
+ Q E+ L +L A++ R+E Q + R++ +++R+
Sbjct: 113 WVTQFVQKKEERD-LVDRLKAEQARRKQREER--LQQLQHRVQLKYAAKRLRQEEEEREN 169
Query: 180 VHNLDAKV-DSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHT 238
+ L ++ ++G + LE++ S + E + ++++H
Sbjct: 170 LLRLSREMLETGPEAER---LEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEH- 225
Query: 239 GKSKIPKIYFGTRTHKQIAQITRELRRTAYS-GVPMTILSSRDHTCVHPEV--VGNFNR- 294
I KIY+ +RTH Q+AQ E++++ + V + L SR + CV+ +V +G+
Sbjct: 226 ----ITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
Query: 295 NEKCMELLDGKNGK------------------SCYFYHGVHKISDQHTLQTFQGMCKAWD 336
N++C+++ ++ K +C FY+ +Q L + + + D
Sbjct: 282 NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYN-----HEQMGLLRDEALAEVKD 336
Query: 337 IEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAH 396
+E+L++LGK+ +ACPYY +R I A ++ PY LL A R++ + L++QVVI+DEAH
Sbjct: 337 MEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAH 396
Query: 397 NIEDCARESASYSVTEVQLRFARDELDSMVNN---NIRKKDHEPLRAVCCSLINWLEANA 453
N+ D S V+ QL A +L V ++ K+ L+ + L ++
Sbjct: 397 NLIDTITGMHSVEVSGSQLCQAHSQLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLG 456
Query: 454 EYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEA 513
+ + + +G E L T++ + I +K ++G E
Sbjct: 457 GNIKQNPNTQSLS-QTGTE-LKTINDFLFQSQIDNINLFKVQRYCEKSMISRKLFGFTE- 513
Query: 514 REVPVISASTQIMLKGLFMVLDYLFRQNSRF----ADDYKIA-------IQQTYSWTNQI 562
R V S+ Q L G L L + + AD+ + + + + +
Sbjct: 514 RYGAVFSSREQPKLAGFQQFLQSLQPRTTEALAAPADESQASTLRPASPLMHIQGFLAAL 573
Query: 563 DISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKS 622
++++G ++L + S+ L F LNPAV F+ + + + +V+ GT+ P+
Sbjct: 574 TTANQDGRVILSRQGSLSQS-----TLKFLLLNPAVHFAQVVKECRAVVIAGGTMQPVSD 628
Query: 623 FSSEL----GVTF--TIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEV 676
F +L GV ++ H+I + I SG + L TFQ E + DEV
Sbjct: 629 FRQQLLACAGVEAERVVEFSCGHVIPPDNILPLVICSGISNQPLEFTFQKRELPQMMDEV 688
Query: 677 GALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFD 736
G +L ++C V G++CF PSY+ L ++ W GL L K + EP+ + +
Sbjct: 689 GRILCNLCGVVPGGVVCFFPSYEYLRQVHAHWEKGGLLGRLAARKKIFQEPKSAHQV--E 746
Query: 737 ELLQVYYDAI----KYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDL 792
++L Y I + +G+ GALL++V GK+SEG++FSD+ R V+ +G+PFPN++
Sbjct: 747 QVLLAYSRCIQACGQERGQVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSA 806
Query: 793 QVELKRQYNDHH-SKLRGLL-PGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFR 850
+++ K Y D + G PG+ E +A+NQ++GR IRH+ D+ +++L+D R+
Sbjct: 807 ELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRYA 866
Query: 851 NNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKK 887
P ++ L W+R +++ +TF A+ ++ +F ++
Sbjct: 867 RPP--VLAKLPAWIRARVEVKATFGPAIAAVQKFHRE 901
>gi|132566527 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
isoform 3 [Homo sapiens]
Length = 970
Score = 231 bits (588), Expect = 4e-60
Identities = 211/850 (24%), Positives = 381/850 (44%), Gaps = 98/850 (11%)
Query: 10 IGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSG 69
+G + FP+ Y Q M + R L + + + ESPTG+GKSL+L+C AL+W +
Sbjct: 8 VGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQ 67
Query: 70 KPADEG----------VSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPSTPPSERN 119
K +E + ++ + L +C GT R P E
Sbjct: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGA--------AGTPR-------PAGEPA 112
Query: 120 GTSSTCQDSPEKTTLAAKLSAKKQASIYRDENDDFQVEKKRIRPLETTQQIRKRHCFGTE 179
+ Q E+ L +L A++ R+E Q + R++ +++R+
Sbjct: 113 WVTQFVQKKEERD-LVDRLKAEQARRKQREER--LQQLQHRVQLKYAAKRLRQEEEEREN 169
Query: 180 VHNLDAKV-DSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHT 238
+ L ++ ++G + LE++ S + E + ++++H
Sbjct: 170 LLRLSREMLETGPEAER---LEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEH- 225
Query: 239 GKSKIPKIYFGTRTHKQIAQITRELRRTAYS-GVPMTILSSRDHTCVHPEV--VGNFNR- 294
I KIY+ +RTH Q+AQ E++++ + V + L SR + CV+ +V +G+
Sbjct: 226 ----ITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
Query: 295 NEKCMELLDGKNGK------------------SCYFYHGVHKISDQHTLQTFQGMCKAWD 336
N++C+++ ++ K +C FY+ +Q L + + + D
Sbjct: 282 NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYN-----HEQMGLLRDEALAEVKD 336
Query: 337 IEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAH 396
+E+L++LGK+ +ACPYY +R I A ++ PY LL A R++ + L++QVVI+DEAH
Sbjct: 337 MEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAH 396
Query: 397 NIEDCARESASYSVTEVQLRFARDELDSMVNN---NIRKKDHEPLRAVCCSLINWLEANA 453
N+ D S V+ QL A +L V ++ K+ L+ + L ++
Sbjct: 397 NLIDTITGMHSVEVSGSQLCQAHSQLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLG 456
Query: 454 EYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEA 513
+ + + +G E L T++ + I +K ++G E
Sbjct: 457 GNIKQNPNTQSLS-QTGTE-LKTINDFLFQSQIDNINLFKVQRYCEKSMISRKLFGFTE- 513
Query: 514 REVPVISASTQIMLKGLFMVLDYLFRQNSRF----ADDYKIA-------IQQTYSWTNQI 562
R V S+ Q L G L L + + AD+ + + + + +
Sbjct: 514 RYGAVFSSREQPKLAGFQQFLQSLQPRTTEALAAPADESQASTLRPASPLMHIQGFLAAL 573
Query: 563 DISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKS 622
++++G ++L + S+ L F LNPAV F+ + + + +V+ GT+ P+
Sbjct: 574 TTANQDGRVILSRQGSLSQS-----TLKFLLLNPAVHFAQVVKECRAVVIAGGTMQPVSD 628
Query: 623 FSSEL----GVTF--TIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEV 676
F +L GV ++ H+I + I SG + L TFQ E + DEV
Sbjct: 629 FRQQLLACAGVEAERVVEFSCGHVIPPDNILPLVICSGISNQPLEFTFQKRELPQMMDEV 688
Query: 677 GALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFD 736
G +L ++C V G++CF PSY+ L ++ W GL L K + EP+ + +
Sbjct: 689 GRILCNLCGVVPGGVVCFFPSYEYLRQVHAHWEKGGLLGRLAARKKIFQEPKSAHQV--E 746
Query: 737 ELLQVYYDAI----KYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDL 792
++L Y I + +G+ GALL++V GK+SEG++FSD+ R V+ +G+PFPN++
Sbjct: 747 QVLLAYSRCIQACGQERGQVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSA 806
Query: 793 QVELKRQYND 802
+++ K Y D
Sbjct: 807 ELQEKMAYLD 816
>gi|91984775 regulator of telomere elongation helicase 1 isoform 2
[Homo sapiens]
Length = 1300
Score = 218 bits (555), Expect = 3e-56
Identities = 119/310 (38%), Positives = 177/310 (57%), Gaps = 10/310 (3%)
Query: 588 VLNFWCLNPAVAFSD-INGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQV 646
VL++WC +P + + + V++++LTSGTL+P+ SF+ E+ + F + LE HII Q+
Sbjct: 452 VLSYWCFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEMQIPFPVCLENPHIIDKHQI 511
Query: 647 WVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKE 706
WVG + GP G L + F + E +G L ++ + V G+L F PSY ++EK E
Sbjct: 512 WVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSYPVMEKSLE 571
Query: 707 RWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVS 766
W + L +E +K + VEP+ K +F E + YY + G GA +AVCRGK S
Sbjct: 572 FWRARDLARKMEALKPLFVEPR--SKGSFSETISAYYARVAAPG-STGATFLAVCRGKAS 628
Query: 767 EGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRG----LLPGRQWYEIQAY 822
EGLDFSD N R VI G+P+P D +V LK Q+ D G L G++WY QA
Sbjct: 629 EGLDFSDTNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQFLSGQEWYRQQAS 688
Query: 823 RALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLA 882
RA+NQA+GR IRHR D+GA+ L D RF +R + L WVR ++ + F + +A
Sbjct: 689 RAVNQAIGRVIRHRQDYGAVFLCDHRFAFADAR--AQLPSWVRPHVRVYDNFGHVIRDVA 746
Query: 883 EFSKKHQKVL 892
+F + ++ +
Sbjct: 747 QFFRVAERTM 756
Score = 140 bits (352), Expect = 1e-32
Identities = 76/189 (40%), Positives = 109/189 (57%), Gaps = 6/189 (3%)
Query: 243 IPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCMELL 302
IPKI + +RTH Q+ Q+ ELR T+Y + +L SR+ C+HPEV + + +
Sbjct: 106 IPKIIYASRTHSQLTQVINELRNTSYRP-KVCVLGSREQLCIHPEVKKQESNHLQIHLCR 164
Query: 303 DGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDA 362
+SC+FY+ V + S + L + DIE+LV G K + CPYY +R L Q A
Sbjct: 165 KKVASRSCHFYNNVEEKSLEQELAS-----PILDIEDLVKSGSKHRVCPYYLSRNLKQQA 219
Query: 363 DIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDEL 422
DIIF PYNYLLDA+ R + +++LK VVI DEAHN+E ESAS+ +T L D +
Sbjct: 220 DIIFMPYNYLLDAKSRRAHNIDLKGTVVIFDEAHNVEKMCEESASFDLTPHDLASGLDVI 279
Query: 423 DSMVNNNIR 431
D ++ +
Sbjct: 280 DQVLEEQTK 288
Score = 62.4 bits (150), Expect = 3e-09
Identities = 29/75 (38%), Positives = 47/75 (62%)
Query: 10 IGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSG 69
+ GV + FP++ Y Q M +L L K + +LESPTG+GK+L LLC+ LAW++ L
Sbjct: 6 LNGVTVDFPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWREHLRD 65
Query: 70 KPADEGVSEKAEVQL 84
+ ++E+A+ +L
Sbjct: 66 GISARKIAERAQGEL 80
>gi|7706541 regulator of telomere elongation helicase 1 isoform 1
[Homo sapiens]
Length = 1219
Score = 218 bits (555), Expect = 3e-56
Identities = 119/310 (38%), Positives = 177/310 (57%), Gaps = 10/310 (3%)
Query: 588 VLNFWCLNPAVAFSD-INGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQV 646
VL++WC +P + + + V++++LTSGTL+P+ SF+ E+ + F + LE HII Q+
Sbjct: 452 VLSYWCFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEMQIPFPVCLENPHIIDKHQI 511
Query: 647 WVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKE 706
WVG + GP G L + F + E +G L ++ + V G+L F PSY ++EK E
Sbjct: 512 WVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSYPVMEKSLE 571
Query: 707 RWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVS 766
W + L +E +K + VEP+ K +F E + YY + G GA +AVCRGK S
Sbjct: 572 FWRARDLARKMEALKPLFVEPR--SKGSFSETISAYYARVAAPG-STGATFLAVCRGKAS 628
Query: 767 EGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRG----LLPGRQWYEIQAY 822
EGLDFSD N R VI G+P+P D +V LK Q+ D G L G++WY QA
Sbjct: 629 EGLDFSDTNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQFLSGQEWYRQQAS 688
Query: 823 RALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLA 882
RA+NQA+GR IRHR D+GA+ L D RF +R + L WVR ++ + F + +A
Sbjct: 689 RAVNQAIGRVIRHRQDYGAVFLCDHRFAFADAR--AQLPSWVRPHVRVYDNFGHVIRDVA 746
Query: 883 EFSKKHQKVL 892
+F + ++ +
Sbjct: 747 QFFRVAERTM 756
Score = 140 bits (352), Expect = 1e-32
Identities = 76/189 (40%), Positives = 109/189 (57%), Gaps = 6/189 (3%)
Query: 243 IPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCMELL 302
IPKI + +RTH Q+ Q+ ELR T+Y + +L SR+ C+HPEV + + +
Sbjct: 106 IPKIIYASRTHSQLTQVINELRNTSYRP-KVCVLGSREQLCIHPEVKKQESNHLQIHLCR 164
Query: 303 DGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDA 362
+SC+FY+ V + S + L + DIE+LV G K + CPYY +R L Q A
Sbjct: 165 KKVASRSCHFYNNVEEKSLEQELAS-----PILDIEDLVKSGSKHRVCPYYLSRNLKQQA 219
Query: 363 DIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDEL 422
DIIF PYNYLLDA+ R + +++LK VVI DEAHN+E ESAS+ +T L D +
Sbjct: 220 DIIFMPYNYLLDAKSRRAHNIDLKGTVVIFDEAHNVEKMCEESASFDLTPHDLASGLDVI 279
Query: 423 DSMVNNNIR 431
D ++ +
Sbjct: 280 DQVLEEQTK 288
Score = 62.4 bits (150), Expect = 3e-09
Identities = 29/75 (38%), Positives = 47/75 (62%)
Query: 10 IGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSG 69
+ GV + FP++ Y Q M +L L K + +LESPTG+GK+L LLC+ LAW++ L
Sbjct: 6 LNGVTVDFPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWREHLRD 65
Query: 70 KPADEGVSEKAEVQL 84
+ ++E+A+ +L
Sbjct: 66 GISARKIAERAQGEL 80
>gi|100913204 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
isoform 2 [Homo sapiens]
Length = 856
Score = 211 bits (538), Expect = 3e-54
Identities = 218/937 (23%), Positives = 407/937 (43%), Gaps = 152/937 (16%)
Query: 10 IGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSG 69
+G + FP+ Y Q M + R L + + + ESPTG+GKSL+L+C AL+W +
Sbjct: 8 VGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQ 67
Query: 70 KPADEG----------VSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPSTPPSERN 119
K +E + ++ + L +C GT R P E
Sbjct: 68 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGA--------AGTPR-------PAGEPA 112
Query: 120 GTSSTCQDSPEKTTLAAKLSAKKQASIYRDENDDFQVEKKRIRPLETTQQIRKRHCFGTE 179
+ Q E+ L +L A++ R+E Q + R++ +++R+
Sbjct: 113 WVTQFVQKKEERD-LVDRLKAEQARRKQREER--LQQLQHRVQLKYAAKRLRQEEEEREN 169
Query: 180 VHNLDAKV-DSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHT 238
+ L ++ ++G + LE++ S + E + ++++H
Sbjct: 170 LLRLSREMLETGPEAER---LEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEH- 225
Query: 239 GKSKIPKIYFGTRTHKQIAQITRELRRTAYS-GVPMTILSSRDHTCVHPEV--VGNFNR- 294
I KIY+ +RTH Q+AQ E++++ + V + L SR + CV+ +V +G+
Sbjct: 226 ----ITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLI 281
Query: 295 NEKCMELLDGKNGK------------------SCYFYHGVHKISDQHTLQTFQGMCKAWD 336
N++C+++ ++ K +C FY+ +Q L + + + D
Sbjct: 282 NDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYN-----HEQMGLLRDEALAEVKD 336
Query: 337 IEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAH 396
+E+L++LGK+ +ACPYY +R I A ++ PY LL A R++ + L++QVVI+DEAH
Sbjct: 337 MEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAH 396
Query: 397 NIEDCARESASYSVTEVQLRFARDELDSMV---NNNIRKKDHEPLRAVCCSLINWLEANA 453
N+ D S V+ QL A +L V ++ K+ L+ + L+ A
Sbjct: 397 NLIDTITGMHSVEVSGSQLCQAHSQLLQYVERYGKRLKAKNLMYLKQI-LYLLEKFVAVL 455
Query: 454 EYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEA 513
++++ + +G E L T++ + I +K ++G E
Sbjct: 456 GGNIKQNPNTQSLSQTGTE-LKTINDFLFQSQIDNINLFKVQRYCEKSMISRKLFGFTE- 513
Query: 514 REVPVISASTQIMLKGLFMVLDYLFRQNSRF----ADDYKIA-------IQQTYSWTNQI 562
R V S+ Q L G L L + + AD+ + + + + +
Sbjct: 514 RYGAVFSSREQPKLAGFQQFLQSLQPRTTEALAAPADESQASTLRPASPLMHIQGFLAAL 573
Query: 563 DISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKS 622
++++G ++L + S+ L F LNPAV F+ + + + +V+ GT+ P+
Sbjct: 574 TTANQDGRVILSRQGSLSQS-----TLKFLLLNPAVHFAQVVKECRAVVIAGGTMQPVSD 628
Query: 623 FSSEL----GVTF--TIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEV 676
F +L GV ++ H+I + I SG + L TFQ E
Sbjct: 629 FRQQLLACAGVEAERVVEFSCGHVIPPDNILPLVICSGISNQPLEFTFQKRE-------- 680
Query: 677 GALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFD 736
L + + EP+ + +
Sbjct: 681 ------------------------------------------LPQMIFQEPKSAHQV--E 696
Query: 737 ELLQVYYDAI----KYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDL 792
++L Y I + +G+ GALL++V GK+SEG++FSD+ R V+ +G+PFPN++
Sbjct: 697 QVLLAYSRCIQACGQERGQVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSA 756
Query: 793 QVELKRQYNDHH-SKLRGLL-PGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFR 850
+++ K Y D + G PG+ E +A+NQ++GR IRH+ D+ +++L+D R+
Sbjct: 757 ELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKAVNQSIGRAIRHQKDFASVVLLDQRYA 816
Query: 851 NNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKK 887
P ++ L W+R +++ +TF A+ ++ +F ++
Sbjct: 817 RPP--VLAKLPAWIRARVEVKATFGPAIAAVQKFHRE 851
>gi|15834617 excision repair cross-complementing rodent repair
deficiency, complementation group 2 protein isoform 1
[Homo sapiens]
Length = 760
Score = 171 bits (433), Expect = 4e-42
Identities = 170/671 (25%), Positives = 292/671 (43%), Gaps = 79/671 (11%)
Query: 242 KIPKIYFGTRTHKQIAQITRELRRTA-----YSGVPMTIL----SSRDHTCVHPEVVG-N 291
++ K+ + +RT +I ++ ELR+ G + L SSR + C+HPEV
Sbjct: 66 EVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLR 125
Query: 292 FNR--NEKCMELL---------DGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEEL 340
F + + KC L + C FY + L +++++L
Sbjct: 126 FGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLP-----AGIYNLDDL 180
Query: 341 VSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNL-KEQVVILDEAHNIE 399
+LG++ CPY+ AR I A+++ Y+YLLD +I + + L ++ VV+ DEAHNI+
Sbjct: 181 KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID 240
Query: 400 DCARESASYSVTEVQLRFARDELDSMVNN--NIRKKDHEPLRAVCCSLINWLEANAEYLV 457
+ +S S ++T L + L+++ I++ D + LR L+ L A
Sbjct: 241 NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLR-EASAAR 299
Query: 458 ERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVP 517
E D A + +E+L I TA HF L++ + Y K R
Sbjct: 300 ETDAHLANPVLP-DEVLQEAVPGSIRTAE------HFLGFLRRLLE----YVKWRLRVQH 348
Query: 518 VISASTQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYSWTNQIDISD----------- 566
V+ S L GL + + R+ RF + ++ T T+ D S
Sbjct: 349 VVQESPPAFLSGLAQRV-CIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLV 407
Query: 567 ---KNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSF 623
G ++ + A +L+F C++ ++A + + Q++++TSGTLSP+ +
Sbjct: 408 STYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIY 467
Query: 624 SSELG------VTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVG 677
L TFT+ L + IG G + + F+ E G
Sbjct: 468 PKILDFHPVTMATFTMTLARVCLCPM------IIGRGNDQVAISSKFETREDIAVIRNYG 521
Query: 678 ALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDE 737
LLL + V GI+ F SY+ +E W G+ N++ K + +E Q G +T+
Sbjct: 522 NLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSV-- 579
Query: 738 LLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELK 797
L+ Y +A + GA+L++V RGKVSEG+DF RAVI G+P+ + ++ +
Sbjct: 580 ALEKYQEACE---NGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKAR 636
Query: 798 RQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYI 857
+Y ++R + A R Q +GR IR + D+G ++ D RF R
Sbjct: 637 LEYLRDQFQIR----ENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKR-- 690
Query: 858 SGLSKWVRQQI 868
L +W+++ +
Sbjct: 691 GKLPRWIQEHL 701
Score = 51.6 bits (122), Expect = 5e-06
Identities = 23/58 (39%), Positives = 40/58 (68%), Gaps = 1/58 (1%)
Query: 10 IGGVKIYFPYK-AYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQS 66
+ G+ +YFPY YP Q + M + R L++K H +LE P+G+GK+++LL +A+Q++
Sbjct: 5 VDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRA 62
>gi|239755744 PREDICTED: similar to Putative ATP-dependent RNA
helicase DDX11-like protein [Homo sapiens]
Length = 223
Score = 135 bits (341), Expect = 2e-31
Identities = 73/220 (33%), Positives = 130/220 (59%), Gaps = 10/220 (4%)
Query: 674 DEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKT 733
DEVG +L ++C VS G++CF PSY+ L ++ W GL L K + EP+ +
Sbjct: 3 DEVGRILCNLCVVVSGGVVCFFPSYEYLRQVHAHWEKGGLLGRLAARKKIFQEPKSAHQV 62
Query: 734 NFDELLQVYYDAIKYKGEKDG----ALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNV 789
+++L Y I+ G++ G ALL++V GK+SEG++FSD+ R V+ +G+PFPN+
Sbjct: 63 --EQVLLAYSRCIQACGQERGQVTEALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNI 120
Query: 790 KDLQVELKRQYNDHH-SKLRGLL-PGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDD 847
+ +++ K Y D + G PG+ E +A+NQ++GR IRH+ D+ +++L+D
Sbjct: 121 RSAELQEKMAYLDQTLPRAPGQAPPGKALVENLCMKAVNQSIGRAIRHQKDFASIVLLDQ 180
Query: 848 RFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKK 887
R+ P ++ L W+R +++ +TF A+ ++ +F ++
Sbjct: 181 RYARPP--VLAKLPAWIRARVEVKATFGPAIAAVQKFHRE 218
>gi|195947407 excision repair cross-complementing rodent repair
deficiency, complementation group 2 protein isoform 2
[Homo sapiens]
Length = 405
Score = 71.2 bits (173), Expect = 6e-12
Identities = 58/220 (26%), Positives = 105/220 (47%), Gaps = 27/220 (12%)
Query: 242 KIPKIYFGTRTHKQIAQITRELRRTA-----YSGVPMTIL----SSRDHTCVHPEVVG-N 291
++ K+ + +RT +I ++ ELR+ G + L SSR + C+HPEV
Sbjct: 42 EVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLR 101
Query: 292 FNR--NEKCMELL---------DGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEEL 340
F + + KC L + C FY + L +++++L
Sbjct: 102 FGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLP-----AGIYNLDDL 156
Query: 341 VSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNL-KEQVVILDEAHNIE 399
+LG++ CPY+ AR I A+++ Y+YLLD +I + + L ++ VV+ DEAHNI+
Sbjct: 157 KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID 216
Query: 400 DCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLR 439
+ +S S ++T L + L+++ +R K+ + R
Sbjct: 217 NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQR 256
Score = 35.4 bits (80), Expect = 0.34
Identities = 15/38 (39%), Positives = 28/38 (73%)
Query: 29 MNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQS 66
M + R L++K H +LE P+G+GK+++LL +A+Q++
Sbjct: 1 MRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRA 38
>gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens]
Length = 935
Score = 37.0 bits (84), Expect = 0.12
Identities = 84/374 (22%), Positives = 142/374 (37%), Gaps = 55/374 (14%)
Query: 819 IQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESAL 878
+Q AL +A +RH + I D + +N +SG + + +H A
Sbjct: 19 LQRDAALKRAEEERVRHLPE---KIKDDQQLKN-----MSGQWFYEAKAKRHRDKIHGAD 70
Query: 879 ESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTPPYLL-------EAASHLSP 931
A KK ++ KDR N ES + + PP L E A+ SP
Sbjct: 71 IIRASMRKKRPQIAAEQSKDREN-GAKESWVNNVNKDAFLPPELAGVVEEPEEDAAPASP 129
Query: 932 ENFVEDEAKICVQELQ--------CPKIITKN----SPLPSSIISRKEKNDP-----VFL 974
+ V + A + Q P+ KN S LP S++ KN+ L
Sbjct: 130 SSSVVNPASSVIDMSQENTRKPNVSPEKQRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGL 189
Query: 975 EEAGKAEKIVISRSTSPTFNKQTKRVSWSSFN----SLGQYFTGKIPKATPELGSS---- 1026
+ K +++ S+ S + +++ S S G IPKA + S
Sbjct: 190 FQTSKEDELSESKEKSTVADTSIQKLEKSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLN 249
Query: 1027 ENSASSPPRFKTEKMESKTVL-------PFTDKCESSNLTVNTSFGSCPQSETIISSLKI 1079
++ S PR +T+ ++++ + +S L N +F P+S+ + L I
Sbjct: 250 KDDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFE--PKSKIVSPGLTI 307
Query: 1080 DATLTRKNHSEHPLCSEEALDP--DIELSLVSEEDKQSTS---NRDFETEAEDESIYFTP 1134
++ K HS S +L+P + S V +E QS R+ + ES
Sbjct: 308 HERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKN 367
Query: 1135 ELYDPEDTDEEKND 1148
+ D DT+E ++D
Sbjct: 368 GMEDAGDTEEFQSD 381
>gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens]
Length = 910
Score = 35.8 bits (81), Expect = 0.26
Identities = 81/373 (21%), Positives = 143/373 (38%), Gaps = 54/373 (14%)
Query: 819 IQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESAL 878
+Q AL +A +RH + I D + +N +SG + + +H A
Sbjct: 19 LQRDAALKRAEEERVRHLPE---KIKDDQQLKN-----MSGQWFYEAKAKRHRDKIHGAD 70
Query: 879 ESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTPPYLL-------EAASHLSP 931
A KK ++ KDR N ES + + PP L E A+ SP
Sbjct: 71 IIRASMRKKRPQIAAEQSKDREN-GAKESWVNNVNKDAFLPPELAGVVEEPEEDAAPASP 129
Query: 932 ENFVEDEAKICV----QELQCPKIITK-------NSPLPSSIISRKEKNDP-----VFLE 975
+ V + A + + + P + + +S LP S++ KN+ L
Sbjct: 130 SSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLF 189
Query: 976 EAGKAEKIVISRSTSPTFNKQTKRVSWSSFN----SLGQYFTGKIPKATPELGSS----E 1027
+ K +++ S+ S + +++ S S G IPKA + S +
Sbjct: 190 QTSKEDELSESKEKSTVADTSIQKLEKSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNK 249
Query: 1028 NSASSPPRFKTEKMESKTVL-------PFTDKCESSNLTVNTSFGSCPQSETIISSLKID 1080
+ S PR +T+ ++++ + +S L N +F P+S+ + L I
Sbjct: 250 DDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFE--PKSKIVSPGLTIH 307
Query: 1081 ATLTRKNHSEHPLCSEEALDP--DIELSLVSEEDKQSTS---NRDFETEAEDESIYFTPE 1135
++ K HS S +L+P + S V +E QS R+ + ES
Sbjct: 308 ERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKNG 367
Query: 1136 LYDPEDTDEEKND 1148
+ D DT+E ++D
Sbjct: 368 MEDAGDTEEFQSD 380
>gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens]
Length = 934
Score = 35.8 bits (81), Expect = 0.26
Identities = 81/373 (21%), Positives = 143/373 (38%), Gaps = 54/373 (14%)
Query: 819 IQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESAL 878
+Q AL +A +RH + I D + +N +SG + + +H A
Sbjct: 19 LQRDAALKRAEEERVRHLPE---KIKDDQQLKN-----MSGQWFYEAKAKRHRDKIHGAD 70
Query: 879 ESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTPPYLL-------EAASHLSP 931
A KK ++ KDR N ES + + PP L E A+ SP
Sbjct: 71 IIRASMRKKRPQIAAEQSKDREN-GAKESWVNNVNKDAFLPPELAGVVEEPEEDAAPASP 129
Query: 932 ENFVEDEAKICV----QELQCPKIITK-------NSPLPSSIISRKEKNDP-----VFLE 975
+ V + A + + + P + + +S LP S++ KN+ L
Sbjct: 130 SSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLF 189
Query: 976 EAGKAEKIVISRSTSPTFNKQTKRVSWSSFN----SLGQYFTGKIPKATPELGSS----E 1027
+ K +++ S+ S + +++ S S G IPKA + S +
Sbjct: 190 QTSKEDELSESKEKSTVADTSIQKLEKSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNK 249
Query: 1028 NSASSPPRFKTEKMESKTVL-------PFTDKCESSNLTVNTSFGSCPQSETIISSLKID 1080
+ S PR +T+ ++++ + +S L N +F P+S+ + L I
Sbjct: 250 DDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFE--PKSKIVSPGLTIH 307
Query: 1081 ATLTRKNHSEHPLCSEEALDP--DIELSLVSEEDKQSTS---NRDFETEAEDESIYFTPE 1135
++ K HS S +L+P + S V +E QS R+ + ES
Sbjct: 308 ERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKNG 367
Query: 1136 LYDPEDTDEEKND 1148
+ D DT+E ++D
Sbjct: 368 MEDAGDTEEFQSD 380
>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
Length = 1790
Score = 35.8 bits (81), Expect = 0.26
Identities = 31/124 (25%), Positives = 54/124 (43%), Gaps = 8/124 (6%)
Query: 1082 TLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPED 1141
TL ++ +E + SEE D + SEE+ + + + E E+E E TP +
Sbjct: 1590 TLDQEEATESTVESEEESSSDY--TEYSEEESEFSESETTEEESESE----TPSEEEESS 1643
Query: 1142 TDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILHI 1201
T E + + G + N +LA+ + +KEV +E E+ + K+ H
Sbjct: 1644 TPESEESESTESEGEKARKN--IVLARRRPMVEEVKEVKGRKEEPQEEQKEPKMEEEEHS 1701
Query: 1202 EESK 1205
EE +
Sbjct: 1702 EEEE 1705
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 35.0 bits (79), Expect = 0.45
Identities = 24/72 (33%), Positives = 33/72 (45%), Gaps = 7/72 (9%)
Query: 70 KPADEGVSEKAEVQLSC-CCACHSKDFTNNDMNQGTSRHFNYPSTP------PSERNGTS 122
K D+G +K S C A S D T +++ GT +YP+TP SE T
Sbjct: 2703 KITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKETL 2762
Query: 123 STCQDSPEKTTL 134
T Q S ++ TL
Sbjct: 2763 GTLQSSQQQPTL 2774
Score = 32.3 bits (72), Expect = 2.9
Identities = 22/69 (31%), Positives = 32/69 (46%), Gaps = 1/69 (1%)
Query: 1095 SEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDR 1154
S LDP+ E EED S SN D + ++E E D ED + E+ D + D
Sbjct: 2403 SMNILDPEDEEEHTQEED-SSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDD 2461
Query: 1155 GNRLANNSD 1163
G+ + + D
Sbjct: 2462 GSEMELDED 2470
>gi|52694665 zinc finger and BTB domain containing 20 [Homo sapiens]
Length = 668
Score = 35.0 bits (79), Expect = 0.45
Identities = 26/74 (35%), Positives = 36/74 (48%), Gaps = 10/74 (13%)
Query: 1021 PELGSSENSASSPPRFKTEKMESK--TVLPFTDKCESSNLTVNTSFGS--------CPQS 1070
P+ E ASSP R +M+S TV +DK +VNTS G Q+
Sbjct: 348 PQTNQLETGASSPERSNEVEMDSTVITVSNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQT 407
Query: 1071 ETIISSLKIDATLT 1084
ET+ S+L++ TLT
Sbjct: 408 ETLTSNLRMPLTLT 421
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 35.0 bits (79), Expect = 0.45
Identities = 29/104 (27%), Positives = 50/104 (48%), Gaps = 4/104 (3%)
Query: 892 LNVSIKDRTNIQDNESTLEVTSLKYSTPPYLLEAASHLSPENFVEDEAKICVQEL-QCPK 950
L+V KD +Q + T +VT+L YS YL ++ + + IC L P
Sbjct: 153 LSVMPKDEDILQVLQFTKDVTALAYSQDAYLKGNEAYSGNARNIPEPPPICYPWLPSAPS 212
Query: 951 IITKNSPL--PSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPT 992
+ + + P S +S+++ + PV L + G+A ++ I SPT
Sbjct: 213 AMAQPVEISPPDSSLSKQQTSTPV-LTQPGRAYRMEIQVPPSPT 255
>gi|145553976 zinc finger, CW type with coiled-coil domain 2 isoform a
[Homo sapiens]
Length = 937
Score = 35.0 bits (79), Expect = 0.45
Identities = 65/293 (22%), Positives = 115/293 (39%), Gaps = 47/293 (16%)
Query: 904 DNESTLEVTSLKYSTPPYLL-------------EAASHLSPENFVEDEAKICVQEL--QC 948
+ E++ + +S + STPPYL S L P + + + +EL Q
Sbjct: 607 EGENSHDKSSSERSTPPYLFPEYPEASKNTGQNREVSILYPGAKDQRQGSLLPEELEDQM 666
Query: 949 PKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSP--TFNKQ---TKRVSWS 1003
P+++ + S S+ I+++E N F+ G A+ + S + FN++ +R +
Sbjct: 667 PRLVAEESNRGSTTINKEEVNKGPFVAVVGVAKGVRDSGAPIQLIPFNREELAERRKAVE 726
Query: 1004 SFNSLG-QYFTGKIPKAT---PELGSSENSASSPPRFK-----------TEKMESKTVLP 1048
S+N + + IP A G E+ + P+ K TEK+E VL
Sbjct: 727 SWNPVPYSVASAAIPAAAIGEKARGYEESEGHNTPKLKNQRELEELKRTTEKLE--RVLA 784
Query: 1049 ----FTDKCESSNLTVN---TSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDP 1101
F K E N + F I S+ + + K H + + L
Sbjct: 785 ERNLFQQKVEELEQERNHWQSEFKKVQHELVIYSTQEAEGLYWSKKHMGYRQAEFQILKA 844
Query: 1102 DIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDR 1154
++E ++E+KQ + ETE E + Y + D+ + LA+ R
Sbjct: 845 ELER---TKEEKQELKEKLKETETHLEMLQKAQVSYRTPEGDDLERALAKLTR 894
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 34.7 bits (78), Expect = 0.58
Identities = 22/70 (31%), Positives = 33/70 (47%), Gaps = 8/70 (11%)
Query: 1076 SLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPE 1135
+L+ D T+ N S+ EE + EE+++ DFE E EDE YF E
Sbjct: 873 ALEEDLTVININSSDEEEEEEEEEE--------EEEEEEEEEEEDFEEEEEDEEEYFEEE 924
Query: 1136 LYDPEDTDEE 1145
+ E+ +EE
Sbjct: 925 EEEEEEFEEE 934
>gi|122891870 melanoma inhibitory activity family, member 3 [Homo
sapiens]
Length = 1907
Score = 33.9 bits (76), Expect = 1.00
Identities = 51/214 (23%), Positives = 88/214 (41%), Gaps = 32/214 (14%)
Query: 949 PKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRV--SWSSFN 1006
P++ + P P + + E++D VF E ++ ++ N Q +SF
Sbjct: 169 PELSKEREPEPEPVEANSEESDSVFSENTEDLQEQFTTQKHHSHANSQANHAQGEQASFE 228
Query: 1007 SLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGS 1066
S + K+ PE +++ S SS + +K+++ +L + L + T FGS
Sbjct: 229 SFEEMLQDKL--KVPESENNKTSNSSQVSNEQDKIDAYKLLK-----KEMTLDLKTKFGS 281
Query: 1067 CPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFE---- 1122
++ ++S D TR S EE D E V +ED++ + DF+
Sbjct: 282 --TADALVS----DDETTRLVTSLEDDFDEEL---DTEYYAVGKEDEE--NQEDFDELPL 330
Query: 1123 ---TEAEDESIYFTPELYDPE--DTDEEKNDLAE 1151
T+ ED TP E TD+E+N E
Sbjct: 331 LTFTDGEDMK---TPAKSGVEKYPTDKEQNSNEE 361
>gi|91982772 mucin 17 [Homo sapiens]
Length = 4493
Score = 33.9 bits (76), Expect = 1.00
Identities = 57/234 (24%), Positives = 93/234 (39%), Gaps = 30/234 (12%)
Query: 905 NESTLEVTSLKYSTPPYLLEAASHLSPENFVEDEAKI--CVQELQCPKIITKNSPLPSS- 961
+E + +TS+ ST P AS+LS V+ + ++ + P NS +P+S
Sbjct: 448 SEGSTPLTSMPVSTTPVASSEASNLSTTP-VDSKTQVTTSTEASSSPPTAEVNS-MPTST 505
Query: 962 -------IISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSW--------SSFN 1006
+ S PV EA + ST T + + S +S
Sbjct: 506 PSEGSTPLTSMSVSTMPVASSEASTLSTTPVDTSTPVTTSSEASSSSTTPEGTSIPTSTP 565
Query: 1007 SLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTV-NTSFG 1065
S G +P +T + SSE S +S T +S T + + + SS+ T TS
Sbjct: 566 SEGSTPLTNMPVSTRLVVSSEASTTS-----TTPADSNTFVTTSSEASSSSTTAEGTSMP 620
Query: 1066 SCPQSE--TIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTS 1117
+ SE T I+S+ + TL SE S +D + ++ +E ST+
Sbjct: 621 TSTYSERGTTITSMSVSTTLVAS--SEASTLSTTPVDSNTPVTTSTEATSSSTT 672
>gi|193788732 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 5 [Homo sapiens]
Length = 2166
Score = 33.5 bits (75), Expect = 1.3
Identities = 42/210 (20%), Positives = 74/210 (35%), Gaps = 18/210 (8%)
Query: 960 SSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKA 1019
S ++ +E+ D E A + I R F ++ Q FT + P
Sbjct: 1698 SGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLH 1757
Query: 1020 TPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTV----NTSFGSCPQSETIIS 1075
+ GSS+ SP EK+ T P + SN + NT+ G P+ S
Sbjct: 1758 INKAGSSQGDTESPSH---EKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPS 1814
Query: 1076 SLKID-------ATLTRKNHSEHPLCSEEALDPDIELSLVSEE----DKQSTSNRDFETE 1124
++ + R L S + + ++ +E D+ + +TE
Sbjct: 1815 TVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTE 1874
Query: 1125 AEDESIYFTPELYDPEDTDEEKNDLAETDR 1154
A E + E+ +D + + L E D+
Sbjct: 1875 ACSEPSLLSTEMLSYQDDENRQLTLPEEDK 1904
>gi|193788728 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 3 [Homo sapiens]
Length = 2179
Score = 33.5 bits (75), Expect = 1.3
Identities = 42/210 (20%), Positives = 74/210 (35%), Gaps = 18/210 (8%)
Query: 960 SSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKA 1019
S ++ +E+ D E A + I R F ++ Q FT + P
Sbjct: 1711 SGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLH 1770
Query: 1020 TPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTV----NTSFGSCPQSETIIS 1075
+ GSS+ SP EK+ T P + SN + NT+ G P+ S
Sbjct: 1771 INKAGSSQGDTESPSH---EKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPS 1827
Query: 1076 SLKID-------ATLTRKNHSEHPLCSEEALDPDIELSLVSEE----DKQSTSNRDFETE 1124
++ + R L S + + ++ +E D+ + +TE
Sbjct: 1828 TVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTE 1887
Query: 1125 AEDESIYFTPELYDPEDTDEEKNDLAETDR 1154
A E + E+ +D + + L E D+
Sbjct: 1888 ACSEPSLLSTEMLSYQDDENRQLTLPEEDK 1917
>gi|193788724 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 2 [Homo sapiens]
Length = 2186
Score = 33.5 bits (75), Expect = 1.3
Identities = 42/210 (20%), Positives = 74/210 (35%), Gaps = 18/210 (8%)
Query: 960 SSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKA 1019
S ++ +E+ D E A + I R F ++ Q FT + P
Sbjct: 1718 SGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLH 1777
Query: 1020 TPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTV----NTSFGSCPQSETIIS 1075
+ GSS+ SP EK+ T P + SN + NT+ G P+ S
Sbjct: 1778 INKAGSSQGDTESPSH---EKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPS 1834
Query: 1076 SLKID-------ATLTRKNHSEHPLCSEEALDPDIELSLVSEE----DKQSTSNRDFETE 1124
++ + R L S + + ++ +E D+ + +TE
Sbjct: 1835 TVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTE 1894
Query: 1125 AEDESIYFTPELYDPEDTDEEKNDLAETDR 1154
A E + E+ +D + + L E D+
Sbjct: 1895 ACSEPSLLSTEMLSYQDDENRQLTLPEEDK 1924
>gi|120433602 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 18 [Homo sapiens]
Length = 2138
Score = 33.5 bits (75), Expect = 1.3
Identities = 42/210 (20%), Positives = 74/210 (35%), Gaps = 18/210 (8%)
Query: 960 SSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKA 1019
S ++ +E+ D E A + I R F ++ Q FT + P
Sbjct: 1670 SGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLH 1729
Query: 1020 TPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTV----NTSFGSCPQSETIIS 1075
+ GSS+ SP EK+ T P + SN + NT+ G P+ S
Sbjct: 1730 INKAGSSQGDTESPSH---EKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPS 1786
Query: 1076 SLKID-------ATLTRKNHSEHPLCSEEALDPDIELSLVSEE----DKQSTSNRDFETE 1124
++ + R L S + + ++ +E D+ + +TE
Sbjct: 1787 TVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTE 1846
Query: 1125 AEDESIYFTPELYDPEDTDEEKNDLAETDR 1154
A E + E+ +D + + L E D+
Sbjct: 1847 ACSEPSLLSTEMLSYQDDENRQLTLPEEDK 1876
>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 20 [Homo sapiens]
Length = 2127
Score = 33.5 bits (75), Expect = 1.3
Identities = 42/210 (20%), Positives = 74/210 (35%), Gaps = 18/210 (8%)
Query: 960 SSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKA 1019
S ++ +E+ D E A + I R F ++ Q FT + P
Sbjct: 1659 SGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLH 1718
Query: 1020 TPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTV----NTSFGSCPQSETIIS 1075
+ GSS+ SP EK+ T P + SN + NT+ G P+ S
Sbjct: 1719 INKAGSSQGDTESPSH---EKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPS 1775
Query: 1076 SLKID-------ATLTRKNHSEHPLCSEEALDPDIELSLVSEE----DKQSTSNRDFETE 1124
++ + R L S + + ++ +E D+ + +TE
Sbjct: 1776 TVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTE 1835
Query: 1125 AEDESIYFTPELYDPEDTDEEKNDLAETDR 1154
A E + E+ +D + + L E D+
Sbjct: 1836 ACSEPSLLSTEMLSYQDDENRQLTLPEEDK 1865
>gi|193788544 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 19 [Homo sapiens]
Length = 2135
Score = 33.5 bits (75), Expect = 1.3
Identities = 42/210 (20%), Positives = 74/210 (35%), Gaps = 18/210 (8%)
Query: 960 SSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKA 1019
S ++ +E+ D E A + I R F ++ Q FT + P
Sbjct: 1667 SGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLH 1726
Query: 1020 TPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTV----NTSFGSCPQSETIIS 1075
+ GSS+ SP EK+ T P + SN + NT+ G P+ S
Sbjct: 1727 INKAGSSQGDTESPSH---EKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPS 1783
Query: 1076 SLKID-------ATLTRKNHSEHPLCSEEALDPDIELSLVSEE----DKQSTSNRDFETE 1124
++ + R L S + + ++ +E D+ + +TE
Sbjct: 1784 TVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTE 1843
Query: 1125 AEDESIYFTPELYDPEDTDEEKNDLAETDR 1154
A E + E+ +D + + L E D+
Sbjct: 1844 ACSEPSLLSTEMLSYQDDENRQLTLPEEDK 1873
>gi|193788542 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 17 [Homo sapiens]
Length = 2138
Score = 33.5 bits (75), Expect = 1.3
Identities = 42/210 (20%), Positives = 74/210 (35%), Gaps = 18/210 (8%)
Query: 960 SSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKA 1019
S ++ +E+ D E A + I R F ++ Q FT + P
Sbjct: 1670 SGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLH 1729
Query: 1020 TPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTV----NTSFGSCPQSETIIS 1075
+ GSS+ SP EK+ T P + SN + NT+ G P+ S
Sbjct: 1730 INKAGSSQGDTESPSH---EKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPS 1786
Query: 1076 SLKID-------ATLTRKNHSEHPLCSEEALDPDIELSLVSEE----DKQSTSNRDFETE 1124
++ + R L S + + ++ +E D+ + +TE
Sbjct: 1787 TVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTE 1846
Query: 1125 AEDESIYFTPELYDPEDTDEEKNDLAETDR 1154
A E + E+ +D + + L E D+
Sbjct: 1847 ACSEPSLLSTEMLSYQDDENRQLTLPEEDK 1876
>gi|193788540 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 16 [Homo sapiens]
Length = 2138
Score = 33.5 bits (75), Expect = 1.3
Identities = 42/210 (20%), Positives = 74/210 (35%), Gaps = 18/210 (8%)
Query: 960 SSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKA 1019
S ++ +E+ D E A + I R F ++ Q FT + P
Sbjct: 1670 SGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLH 1729
Query: 1020 TPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTV----NTSFGSCPQSETIIS 1075
+ GSS+ SP EK+ T P + SN + NT+ G P+ S
Sbjct: 1730 INKAGSSQGDTESPSH---EKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPS 1786
Query: 1076 SLKID-------ATLTRKNHSEHPLCSEEALDPDIELSLVSEE----DKQSTSNRDFETE 1124
++ + R L S + + ++ +E D+ + +TE
Sbjct: 1787 TVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTE 1846
Query: 1125 AEDESIYFTPELYDPEDTDEEKNDLAETDR 1154
A E + E+ +D + + L E D+
Sbjct: 1847 ACSEPSLLSTEMLSYQDDENRQLTLPEEDK 1876
>gi|193788538 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 15 [Homo sapiens]
Length = 2138
Score = 33.5 bits (75), Expect = 1.3
Identities = 42/210 (20%), Positives = 74/210 (35%), Gaps = 18/210 (8%)
Query: 960 SSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKA 1019
S ++ +E+ D E A + I R F ++ Q FT + P
Sbjct: 1670 SGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLH 1729
Query: 1020 TPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTV----NTSFGSCPQSETIIS 1075
+ GSS+ SP EK+ T P + SN + NT+ G P+ S
Sbjct: 1730 INKAGSSQGDTESPSH---EKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPS 1786
Query: 1076 SLKID-------ATLTRKNHSEHPLCSEEALDPDIELSLVSEE----DKQSTSNRDFETE 1124
++ + R L S + + ++ +E D+ + +TE
Sbjct: 1787 TVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTE 1846
Query: 1125 AEDESIYFTPELYDPEDTDEEKNDLAETDR 1154
A E + E+ +D + + L E D+
Sbjct: 1847 ACSEPSLLSTEMLSYQDDENRQLTLPEEDK 1876
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,097,844
Number of Sequences: 37866
Number of extensions: 2190208
Number of successful extensions: 6901
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 6622
Number of HSP's gapped (non-prelim): 303
length of query: 1249
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1135
effective length of database: 13,930,794
effective search space: 15811451190
effective search space used: 15811451190
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.