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Search of human proteins with 7669532
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
(852 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7669532 neuregulin 2 isoform 4 [Homo sapiens] 1731 0.0
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens] 1707 0.0
gi|7669530 neuregulin 2 isoform 3 [Homo sapiens] 1696 0.0
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens] 1678 0.0
gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens] 395 e-109
gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens] 393 e-109
gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens] 383 e-106
gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens] 383 e-106
gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens] 365 e-100
gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens] 354 2e-97
gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens] 277 3e-74
gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens] 276 4e-74
gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens] 266 6e-71
gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens] 217 4e-56
gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens] 196 8e-50
gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens] 122 1e-27
gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens] 110 6e-24
gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens] 97 5e-20
gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens] 96 2e-19
gi|66730481 neuregulin 3 [Homo sapiens] 87 5e-17
gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens] 86 2e-16
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 65 3e-10
gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens] 61 5e-09
gi|93102361 palladin [Homo sapiens] 60 7e-09
gi|10864029 junctional adhesion molecule 2 precursor [Homo sapiens] 58 3e-08
gi|153792294 myopalladin [Homo sapiens] 58 3e-08
gi|153792780 additional sex combs like 2 [Homo sapiens] 57 9e-08
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 56 1e-07
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 56 2e-07
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 55 3e-07
>gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
Length = 852
Score = 1731 bits (4482), Expect = 0.0
Identities = 852/852 (100%), Positives = 852/852 (100%)
Query: 1 MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA 60
MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA
Sbjct: 1 MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA 60
Query: 61 APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV 120
APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV
Sbjct: 61 APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV 120
Query: 121 QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI 180
QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI
Sbjct: 121 QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI 180
Query: 181 SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK 240
SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK
Sbjct: 181 SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK 240
Query: 241 KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK 300
KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK
Sbjct: 241 KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK 300
Query: 301 VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY 360
VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY
Sbjct: 301 VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY 360
Query: 361 YIEGINQLSCKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRVLTITGICVALLV 420
YIEGINQLSCKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRVLTITGICVALLV
Sbjct: 361 YIEGINQLSCKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRVLTITGICVALLV 420
Query: 421 VGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNV 480
VGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNV
Sbjct: 421 VGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNV 480
Query: 481 PATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIM 540
PATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIM
Sbjct: 481 PATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIM 540
Query: 541 LSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTT 600
LSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTT
Sbjct: 541 LSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTT 600
Query: 601 PARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGP 660
PARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGP
Sbjct: 601 PARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGP 660
Query: 661 GPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQE 720
GPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQE
Sbjct: 661 GPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQE 720
Query: 721 CAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASD 780
CAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASD
Sbjct: 721 CAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASD 780
Query: 781 DDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRG 840
DDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRG
Sbjct: 781 DDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRG 840
Query: 841 PPPRAKQDSAPL 852
PPPRAKQDSAPL
Sbjct: 841 PPPRAKQDSAPL 852
>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
Length = 844
Score = 1707 bits (4420), Expect = 0.0
Identities = 844/852 (99%), Positives = 844/852 (99%), Gaps = 8/852 (0%)
Query: 1 MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA 60
MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA
Sbjct: 1 MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA 60
Query: 61 APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV 120
APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV
Sbjct: 61 APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV 120
Query: 121 QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI 180
QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI
Sbjct: 121 QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI 180
Query: 181 SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK 240
SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK
Sbjct: 181 SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK 240
Query: 241 KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK 300
KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK
Sbjct: 241 KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK 300
Query: 301 VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY 360
VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY
Sbjct: 301 VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY 360
Query: 361 YIEGINQLSCKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRVLTITGICVALLV 420
YIEGINQLSCKCPVGYTGDRCQQFAMVNFSK AEELYQKRVLTITGICVALLV
Sbjct: 361 YIEGINQLSCKCPVGYTGDRCQQFAMVNFSK--------AEELYQKRVLTITGICVALLV 412
Query: 421 VGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNV 480
VGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNV
Sbjct: 413 VGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNV 472
Query: 481 PATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIM 540
PATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIM
Sbjct: 473 PATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIM 532
Query: 541 LSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTT 600
LSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTT
Sbjct: 533 LSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTT 592
Query: 601 PARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGP 660
PARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGP
Sbjct: 593 PARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGP 652
Query: 661 GPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQE 720
GPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQE
Sbjct: 653 GPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQE 712
Query: 721 CAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASD 780
CAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASD
Sbjct: 713 CAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASD 772
Query: 781 DDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRG 840
DDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRG
Sbjct: 773 DDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRG 832
Query: 841 PPPRAKQDSAPL 852
PPPRAKQDSAPL
Sbjct: 833 PPPRAKQDSAPL 844
>gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]
Length = 858
Score = 1696 bits (4391), Expect = 0.0
Identities = 839/858 (97%), Positives = 842/858 (98%), Gaps = 6/858 (0%)
Query: 1 MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA 60
MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA
Sbjct: 1 MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA 60
Query: 61 APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV 120
APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV
Sbjct: 61 APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV 120
Query: 121 QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI 180
QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI
Sbjct: 121 QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI 180
Query: 181 SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK 240
SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK
Sbjct: 181 SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK 240
Query: 241 KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK 300
KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK
Sbjct: 241 KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK 300
Query: 301 VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY 360
VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY
Sbjct: 301 VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY 360
Query: 361 YIEGINQLSCKCPVGYTGDRCQQFAMVNF------SKHLGFELKEAEELYQKRVLTITGI 414
YIEGINQLSCKCP G+ G RC + + KHLGFELKEAEELYQKRVLTITGI
Sbjct: 361 YIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKHLGFELKEAEELYQKRVLTITGI 420
Query: 415 CVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMAD 474
CVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMAD
Sbjct: 421 CVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMAD 480
Query: 475 YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSD 534
YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSD
Sbjct: 481 YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSD 540
Query: 535 SQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERY 594
SQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERY
Sbjct: 541 SQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERY 600
Query: 595 VSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPA 654
VSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPA
Sbjct: 601 VSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPA 660
Query: 655 PPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDE 714
PPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDE
Sbjct: 661 PPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDE 720
Query: 715 YETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGG 774
YETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGG
Sbjct: 721 YETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGG 780
Query: 775 SASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRAS 834
SASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRAS
Sbjct: 781 SASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRAS 840
Query: 835 SRHSRGPPPRAKQDSAPL 852
SRHSRGPPPRAKQDSAPL
Sbjct: 841 SRHSRGPPPRAKQDSAPL 858
>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
Length = 850
Score = 1678 bits (4345), Expect = 0.0
Identities = 830/852 (97%), Positives = 837/852 (98%), Gaps = 2/852 (0%)
Query: 1 MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA 60
MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA
Sbjct: 1 MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA 60
Query: 61 APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV 120
APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV
Sbjct: 61 APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV 120
Query: 121 QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI 180
QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI
Sbjct: 121 QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI 180
Query: 181 SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK 240
SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK
Sbjct: 181 SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK 240
Query: 241 KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK 300
KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK
Sbjct: 241 KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK 300
Query: 301 VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY 360
VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY
Sbjct: 301 VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY 360
Query: 361 YIEGINQLSCKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRVLTITGICVALLV 420
YIEGINQLSCKCP G+ G RC + + ++ ++AEELYQKRVLTITGICVALLV
Sbjct: 361 YIEGINQLSCKCPNGFFGQRCLEKLPLRL--YMPDPKQKAEELYQKRVLTITGICVALLV 418
Query: 421 VGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNV 480
VGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNV
Sbjct: 419 VGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNV 478
Query: 481 PATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIM 540
PATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIM
Sbjct: 479 PATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIM 538
Query: 541 LSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTT 600
LSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTT
Sbjct: 539 LSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTT 598
Query: 601 PARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGP 660
PARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGP
Sbjct: 599 PARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGP 658
Query: 661 GPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQE 720
GPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQE
Sbjct: 659 GPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQE 718
Query: 721 CAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASD 780
CAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASD
Sbjct: 719 CAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASD 778
Query: 781 DDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRG 840
DDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRG
Sbjct: 779 DDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRG 838
Query: 841 PPPRAKQDSAPL 852
PPPRAKQDSAPL
Sbjct: 839 PPPRAKQDSAPL 850
>gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]
Length = 590
Score = 395 bits (1014), Expect = e-109
Identities = 248/613 (40%), Positives = 350/613 (57%), Gaps = 65/613 (10%)
Query: 222 KKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS- 280
K G++ T A P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR
Sbjct: 3 KGRAGRVGTT--ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
Query: 281 --RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSW 338
++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ + + + T +S
Sbjct: 61 KPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 118
Query: 339 SG--HARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNFSKHL 393
+G H KC E K++CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +F KHL
Sbjct: 119 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHL 178
Query: 394 GFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN 453
G E EAEELYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N
Sbjct: 179 GIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNN 238
Query: 454 -RSLANGPSHPRLDPEEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTAT 511
++ANGP HP PE +Q+ + Y+SKNV +++H++ RE ET+FS SH S +HH +T T
Sbjct: 239 MMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVT 298
Query: 512 PTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERR 571
T SH+WS +ES+ S+S S I++SSV S+ +SP R R
Sbjct: 299 QT-----PSHSWSNGHTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPR 349
Query: 572 RATAPPYH--DSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAH 629
+ H ++ DS RDSPHSERYVSA+TTPAR+SPVDFH + + P E++ P S+
Sbjct: 350 ECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSM 409
Query: 630 AVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPR 689
VS+P A +S + E++PLL P P + + S+++ A
Sbjct: 410 TVSMPSMA-VSPFMEEERPLLLVTPPRLREKKFDHHP-------QQFSSFHHNPAHDS-- 459
Query: 690 RGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSR 749
SLPASP RI ED+EYETTQE P P + A RR +R++
Sbjct: 460 ----------NSLPASPLRIVEDEEYETTQEYEPAQEPVKKL--------ANSRRAKRTK 501
Query: 750 LNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRS 809
NG A R L + S + S+++ + D+ G E TPFLG++ A
Sbjct: 502 PNGHIANR-------LEVDSNTSSQSSNSESETEDERVG----EDTPFLGIQNPL-AASL 549
Query: 810 DSPPLCPAADSRT 822
++ P ADSRT
Sbjct: 550 EATPAFRLADSRT 562
>gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]
Length = 607
Score = 393 bits (1009), Expect = e-109
Identities = 249/630 (39%), Positives = 353/630 (56%), Gaps = 82/630 (13%)
Query: 222 KKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS- 280
K G++ T A P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR
Sbjct: 3 KGRAGRVGTT--ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
Query: 281 --RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRL------------ 326
++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 61 KPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGM 118
Query: 327 -------YVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGY 376
YV+S ++T ++ + H KC E K++CVNGG C+ ++ ++ S CKCP +
Sbjct: 119 PASTEGAYVSSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEF 178
Query: 377 TGDRCQQFAMVNFSKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQR 436
TGDRCQ + M +F KHLG E EAEELYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQR
Sbjct: 179 TGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQR 238
Query: 437 KQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQMAD-YISKNVPATDHVIRRETETT 494
K++H+ LRQ++ N ++ANGP HP PE +Q+ + Y+SKNV +++H++ RE ET+
Sbjct: 239 KKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETS 298
Query: 495 FSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPAC 554
FS SH S +HH +T T T SH+WS +ES+ S+S S I++SSV S+ +SP
Sbjct: 299 FSTSHYTSTAHHSTTVTQT-----PSHSWSNGHTESILSESHSVIVMSSVENSRHSSP-- 351
Query: 555 VEARARRAAAYNLEERRRATAPPYH--DSVDSLRDSPHSERYVSALTTPARLSPVDFHYS 612
R R + H ++ DS RDSPHSERYVSA+TTPAR+SPVDFH
Sbjct: 352 --TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTP 409
Query: 613 LATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADM 672
+ + P E++ P S+ VS+P A +S + E++PLL P P
Sbjct: 410 SSPKSPPSEMSPPVSSMTVSMPSMA-VSPFMEEERPLLLVTPPRLREKKFDHHP------ 462
Query: 673 QRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRAR 732
+ + S+++ A SLPASP RI ED+EYETTQE P P +
Sbjct: 463 -QQFSSFHHNPAHDS------------NSLPASPLRIVEDEEYETTQEYEPAQEPVKKL- 508
Query: 733 GASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAA 792
A RR +R++ NG A R L + S + S+++ + D+ G
Sbjct: 509 -------ANSRRAKRTKPNGHIANR-------LEVDSNTSSQSSNSESETEDERVG---- 550
Query: 793 ESTPFLGLRGAHDALRSDSPPLCPAADSRT 822
E TPFLG++ A ++ P ADSRT
Sbjct: 551 EDTPFLGIQNPL-AASLEATPAFRLADSRT 579
>gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]
Length = 624
Score = 383 bits (983), Expect = e-106
Identities = 250/647 (38%), Positives = 353/647 (54%), Gaps = 99/647 (15%)
Query: 222 KKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS- 280
K G++ T A P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR
Sbjct: 3 KGRAGRVGTT--ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
Query: 281 --RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV---------- 328
++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ + +
Sbjct: 61 KPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGM 118
Query: 329 ------------------------NSVSTTLSSWSG--HARKCNETAKSYCVNGGVCYYI 362
N+ S+T +S +G H KC E K++CVNGG C+ +
Sbjct: 119 PASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMV 178
Query: 363 EGINQLS---CKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRVLTITGICVALL 419
+ ++ S CKCP +TGDRCQ + M +F KHLG E EAEELYQKRVLTITGIC+ALL
Sbjct: 179 KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALL 238
Query: 420 VVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQMAD-YIS 477
VVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP PE +Q+ + Y+S
Sbjct: 239 VVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVS 298
Query: 478 KNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQS 537
KNV +++H++ RE ET+FS SH S +HH +T T T SH+WS +ES+ S+S S
Sbjct: 299 KNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNGHTESILSESHS 353
Query: 538 GIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDSLRDSPHSERYV 595
I++SSV S+ +SP R R + H ++ DS RDSPHSERYV
Sbjct: 354 VIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYV 409
Query: 596 SALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAP 655
SA+TTPAR+SPVDFH + + P E++ P S+ VS+P A +S + E++PLL P
Sbjct: 410 SAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMA-VSPFMEEERPLLLVTPP 468
Query: 656 PGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEY 715
P + + S+++ A SLPASP RI ED+EY
Sbjct: 469 RLREKKFDHHP-------QQFSSFHHNPAHDS------------NSLPASPLRIVEDEEY 509
Query: 716 ETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGS 775
ETTQE P P + A RR +R++ NG A R L + S + S
Sbjct: 510 ETTQEYEPAQEPVKKL--------ANSRRAKRTKPNGHIANR-------LEVDSNTSSQS 554
Query: 776 ASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT 822
+++ + D+ G E TPFLG++ A ++ P ADSRT
Sbjct: 555 SNSESETEDERVG----EDTPFLGIQNPL-AASLEATPAFRLADSRT 596
>gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]
Length = 645
Score = 383 bits (983), Expect = e-106
Identities = 253/658 (38%), Positives = 355/658 (53%), Gaps = 104/658 (15%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
+ N+ S+T +S +G H KC E K+
Sbjct: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
Query: 352 YCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRV 408
+CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +F KHLG E EAEELYQKRV
Sbjct: 189 FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRV 248
Query: 409 LTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDP 467
LTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP P
Sbjct: 249 LTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPP 308
Query: 468 EEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLE 526
E +Q+ + Y+SKNV +++H++ RE ET+FS SH S +HH +T T T SH+WS
Sbjct: 309 ENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNG 363
Query: 527 RSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDS 584
+ES+ S+S S I++SSV S+ +SP R R + H ++ DS
Sbjct: 364 HTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDS 419
Query: 585 LRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLA 644
RDSPHSERYVSA+TTPAR+SPVDFH + + P E++ P S+ VS+P A +S +
Sbjct: 420 YRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMA-VSPFME 478
Query: 645 EQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPA 704
E++PLL P P + + S+++ A SLPA
Sbjct: 479 EERPLLLVTPPRLREKKFDHHP-------QQFSSFHHNPAHDS------------NSLPA 519
Query: 705 SPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDS 764
SP RI ED+EYETTQE P P + A RR +R++ NG A R
Sbjct: 520 SPLRIVEDEEYETTQEYEPAQEPVKKL--------ANSRRAKRTKPNGHIANR------- 564
Query: 765 LSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT 822
L + S + S+++ + D+ G E TPFLG++ A ++ P ADSRT
Sbjct: 565 LEVDSNTSSQSSNSESETEDERVG----EDTPFLGIQNPL-AASLEATPAFRLADSRT 617
>gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]
Length = 637
Score = 365 bits (937), Expect = e-100
Identities = 248/658 (37%), Positives = 350/658 (53%), Gaps = 112/658 (17%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
+ N+ S+T +S +G H KC E K+
Sbjct: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
Query: 352 YCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRV 408
+CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +F K AEELYQKRV
Sbjct: 189 FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYK--------AEELYQKRV 240
Query: 409 LTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDP 467
LTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP P
Sbjct: 241 LTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPP 300
Query: 468 EEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLE 526
E +Q+ + Y+SKNV +++H++ RE ET+FS SH S +HH +T T T SH+WS
Sbjct: 301 ENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNG 355
Query: 527 RSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDS 584
+ES+ S+S S I++SSV S+ +SP R R + H ++ DS
Sbjct: 356 HTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDS 411
Query: 585 LRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLA 644
RDSPHSERYVSA+TTPAR+SPVDFH + + P E++ P S+ VS+P A +S +
Sbjct: 412 YRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMA-VSPFME 470
Query: 645 EQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPA 704
E++PLL P P + + S+++ A SLPA
Sbjct: 471 EERPLLLVTPPRLREKKFDHHP-------QQFSSFHHNPAHDS------------NSLPA 511
Query: 705 SPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDS 764
SP RI ED+EYETTQE P P + A RR +R++ NG A R
Sbjct: 512 SPLRIVEDEEYETTQEYEPAQEPVKKL--------ANSRRAKRTKPNGHIANR------- 556
Query: 765 LSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT 822
L + S + S+++ + D+ G E TPFLG++ A ++ P ADSRT
Sbjct: 557 LEVDSNTSSQSSNSESETEDERVG----EDTPFLGIQNPL-AASLEATPAFRLADSRT 609
>gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]
Length = 640
Score = 354 bits (908), Expect = 2e-97
Identities = 243/658 (36%), Positives = 347/658 (52%), Gaps = 109/658 (16%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
+ N+ S+T +S +G H KC E K+
Sbjct: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
Query: 352 YCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRV 408
+CVNGG C+ ++ ++ S CKC G+TG RC + + ++AEELYQKRV
Sbjct: 189 FCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQ-----EKAEELYQKRV 243
Query: 409 LTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDP 467
LTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP P
Sbjct: 244 LTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPP 303
Query: 468 EEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLE 526
E +Q+ + Y+SKNV +++H++ RE ET+FS SH S +HH +T T T SH+WS
Sbjct: 304 ENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNG 358
Query: 527 RSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDS 584
+ES+ S+S S I++SSV S+ +SP R R + H ++ DS
Sbjct: 359 HTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDS 414
Query: 585 LRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLA 644
RDSPHSERYVSA+TTPAR+SPVDFH + + P E++ P S+ VS+P A +S +
Sbjct: 415 YRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMA-VSPFME 473
Query: 645 EQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPA 704
E++PLL P P + + S+++ A SLPA
Sbjct: 474 EERPLLLVTPPRLREKKFDHHP-------QQFSSFHHNPAHDS------------NSLPA 514
Query: 705 SPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDS 764
SP RI ED+EYETTQE P P + A RR +R++ NG A R
Sbjct: 515 SPLRIVEDEEYETTQEYEPAQEPVKKL--------ANSRRAKRTKPNGHIANR------- 559
Query: 765 LSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT 822
L + S + S+++ + D+ G E TPFLG++ A ++ P ADSRT
Sbjct: 560 LEVDSNTSSQSSNSESETEDERVG----EDTPFLGIQNPL-AASLEATPAFRLADSRT 612
>gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]
Length = 459
Score = 277 bits (709), Expect = 3e-74
Identities = 171/430 (39%), Positives = 241/430 (56%), Gaps = 72/430 (16%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
+ N+ S+T +S +G H KC E K+
Sbjct: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
Query: 352 YCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRV 408
+CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +F K AEELYQKRV
Sbjct: 189 FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYK--------AEELYQKRV 240
Query: 409 LTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDP 467
LTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP P
Sbjct: 241 LTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPP 300
Query: 468 EEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLE 526
E +Q+ + Y+SKNV +++H++ RE ET+FS SH S +HH +T T T SH+WS
Sbjct: 301 ENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNG 355
Query: 527 RSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDS 584
+ES+ S+S S I++SSV S+ +SP R R + H ++ DS
Sbjct: 356 HTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDS 411
Query: 585 LRDSPHSERY 594
RDSPHSER+
Sbjct: 412 YRDSPHSERH 421
>gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]
Length = 420
Score = 276 bits (707), Expect = 4e-74
Identities = 171/429 (39%), Positives = 240/429 (55%), Gaps = 72/429 (16%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
+ N+ S+T +S +G H KC E K+
Sbjct: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
Query: 352 YCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRV 408
+CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +F K AEELYQKRV
Sbjct: 189 FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYK--------AEELYQKRV 240
Query: 409 LTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDP 467
LTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP P
Sbjct: 241 LTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPP 300
Query: 468 EEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLE 526
E +Q+ + Y+SKNV +++H++ RE ET+FS SH S +HH +T T T SH+WS
Sbjct: 301 ENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNG 355
Query: 527 RSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDS 584
+ES+ S+S S I++SSV S+ +SP R R + H ++ DS
Sbjct: 356 HTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDS 411
Query: 585 LRDSPHSER 593
RDSPHSER
Sbjct: 412 YRDSPHSER 420
>gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]
Length = 462
Score = 266 bits (680), Expect = 6e-71
Identities = 166/430 (38%), Positives = 238/430 (55%), Gaps = 69/430 (16%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
+ N+ S+T +S +G H KC E K+
Sbjct: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
Query: 352 YCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRV 408
+CVNGG C+ ++ ++ S CKC G+TG RC + + ++AEELYQKRV
Sbjct: 189 FCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQ-----EKAEELYQKRV 243
Query: 409 LTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDP 467
LTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP P
Sbjct: 244 LTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPP 303
Query: 468 EEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLE 526
E +Q+ + Y+SKNV +++H++ RE ET+FS SH S +HH +T T T SH+WS
Sbjct: 304 ENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNG 358
Query: 527 RSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDS 584
+ES+ S+S S I++SSV S+ +SP R R + H ++ DS
Sbjct: 359 HTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDS 414
Query: 585 LRDSPHSERY 594
RDSPHSER+
Sbjct: 415 YRDSPHSERH 424
>gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]
Length = 308
Score = 217 bits (552), Expect = 4e-56
Identities = 120/272 (44%), Positives = 171/272 (62%), Gaps = 21/272 (7%)
Query: 330 SVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAM 386
+ ++T ++ + H KC E K++CVNGG C+ ++ ++ S CKC G+TG RC +
Sbjct: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
Query: 387 VNFSKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQN 446
+ ++AEELYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ+
Sbjct: 73 MKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS 127
Query: 447 MCPAHQN-RSLANGPSHPRLDPEEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPS 504
+ N ++ANGP HP PE +Q+ + Y+SKNV +++H++ RE ET+FS SH S +
Sbjct: 128 LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA 187
Query: 505 HHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAA 564
HH +T T T SH+WS +ES+ S+S S I++SSV S+ +SP R
Sbjct: 188 HHSTTVTQT-----PSHSWSNGHTESILSESHSVIVMSSVENSRHSSP----TGGPRGRL 238
Query: 565 YNLEERRRATAPPYH--DSVDSLRDSPHSERY 594
R + H ++ DS RDSPHSER+
Sbjct: 239 NGTGGPRECNSFLRHARETPDSYRDSPHSERH 270
>gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens]
Length = 422
Score = 196 bits (498), Expect = 8e-50
Identities = 141/418 (33%), Positives = 208/418 (49%), Gaps = 92/418 (22%)
Query: 48 RSSSNNSSISRPAAPPEPRPQQQPQPRSPAARR--AAARSRAAAAGGMRRDPAPGFSMLL 105
RS RP + P P P P AA + AAAG + AP
Sbjct: 9 RSGRPGPRAQRPGSAARSSP---PLPLLPLLLLLGTAALAPGAAAGN---EAAPA----- 57
Query: 106 FGVSLACYS--PSLKSVQDQAYKAPVVVEGKV------QGLVPAGGSSS-------NSTR 150
G S+ CYS PS+ SVQ+ A +A VV+EGKV QG + +++ R
Sbjct: 58 -GASV-CYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDR 115
Query: 151 EPPASGRVAL------------------------------------VKVLDKWPLRSGGL 174
EPPA+G AL VKV W +++GGL
Sbjct: 116 EPPAAGPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGL 175
Query: 175 QREQVISVG----------SCVPLERNQRYIFFLEP-----TEQPLVFKTAFAPLDTNGK 219
+++ +++V SC L+ + RYIFF+EP + P F+ +F PL+T G+
Sbjct: 176 KKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLET-GR 234
Query: 220 NLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNR 279
NLKKEV ++LC CA P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR
Sbjct: 235 NLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNR 294
Query: 280 S---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLS 336
++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ + + + T +
Sbjct: 295 KNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATST 352
Query: 337 SWSG--HARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNF 389
S +G H KC E K++CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +F
Sbjct: 353 STTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF 410
>gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens]
Length = 207
Score = 122 bits (306), Expect = 1e-27
Identities = 69/187 (36%), Positives = 105/187 (56%), Gaps = 17/187 (9%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 VNSVSTTLSSWSG--HARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQ 382
+ + T +S +G H KC E K++CVNGG C+ ++ ++ S CKCP +TGDRCQ
Sbjct: 129 IVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQ 188
Query: 383 QFAMVNF 389
+ M +F
Sbjct: 189 NYVMASF 195
>gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens]
Length = 241
Score = 110 bits (275), Expect = 6e-24
Identities = 71/221 (32%), Positives = 108/221 (48%), Gaps = 51/221 (23%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
+ N+ S+T +S +G H KC E K+
Sbjct: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
Query: 352 YCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNF 389
+CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +F
Sbjct: 189 FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF 229
>gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens]
Length = 177
Score = 97.4 bits (241), Expect = 5e-20
Identities = 57/164 (34%), Positives = 90/164 (54%), Gaps = 14/164 (8%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 VNSVSTTLSSWSG--HARKCNETAKSYCVNGGVCYYIEGINQLS 369
+ + T +S +G H KC E K++CVNGG C+ ++ ++ S
Sbjct: 129 IVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPS 172
>gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens]
Length = 194
Score = 95.5 bits (236), Expect = 2e-19
Identities = 58/181 (32%), Positives = 93/181 (51%), Gaps = 31/181 (17%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRL- 326
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 327 ------------------YVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQL 368
YV+S ++T ++ + H KC E K++CVNGG C+ ++ ++
Sbjct: 129 IVESNEIITGMPASTEGAYVSSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNP 188
Query: 369 S 369
S
Sbjct: 189 S 189
>gi|66730481 neuregulin 3 [Homo sapiens]
Length = 696
Score = 87.4 bits (215), Expect = 5e-17
Identities = 43/114 (37%), Positives = 67/114 (58%), Gaps = 8/114 (7%)
Query: 339 SGHARKCNETAKSYCVNGGVCYYIEGI--NQLSCKCPVGYTGDRCQQFA------MVNFS 390
S H + C + +YC+N G C+ IE + + C+C GY G RC QF + + +
Sbjct: 284 SEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPT 343
Query: 391 KHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLR 444
HLG E E+EE+YQ++VL+I+ I +++VG+ C Y K+KKQ KQ+ L+
Sbjct: 344 DHLGIEFMESEEVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLK 397
>gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens]
Length = 211
Score = 85.5 bits (210), Expect = 2e-16
Identities = 59/198 (29%), Positives = 93/198 (46%), Gaps = 48/198 (24%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
+ N+ S+T +S +G H KC E K+
Sbjct: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
Query: 352 YCVNGGVCYYIEGINQLS 369
+CVNGG C+ ++ ++ S
Sbjct: 189 FCVNGGECFMVKDLSNPS 206
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 65.1 bits (157), Expect = 3e-10
Identities = 40/68 (58%), Positives = 45/68 (66%), Gaps = 1/68 (1%)
Query: 10 PPPPLEKGRCSSYSDSSSSSSERSSSSSS-SSSESGSSSRSSSNNSSISRPAAPPEPRPQ 68
P P K R SS S SSSSSS SSSSSS SSS S SSS SSS++SS S +P +P PQ
Sbjct: 2598 PTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQ 2657
Query: 69 QQPQPRSP 76
P+P SP
Sbjct: 2658 ALPKPASP 2665
Score = 53.1 bits (126), Expect = 1e-06
Identities = 50/159 (31%), Positives = 70/159 (44%), Gaps = 22/159 (13%)
Query: 13 PLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRP------AAPPEPR 66
P ++ R SS S SSSSSS SSSSSSSSS SGSSS S +S +P P P
Sbjct: 2526 PAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPA 2585
Query: 67 PQQ-----QPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSVQ 121
P++ +P +PA R+ + S ++++ + S S + S S S
Sbjct: 2586 PKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSS---SSSSSSSSSSSSSSS 2642
Query: 122 DQAYKAPVVVEGKVQGL--------VPAGGSSSNSTREP 152
+ +P + Q L P G S S R+P
Sbjct: 2643 SSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKP 2681
Score = 52.8 bits (125), Expect = 1e-06
Identities = 41/87 (47%), Positives = 51/87 (58%), Gaps = 7/87 (8%)
Query: 20 SSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQP-----R 74
SS S SSSSSS SSSSSSSSS S SSS SSS + + P A P+P ++P P R
Sbjct: 2617 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSR 2676
Query: 75 SPAARRAAAR-SRAAAAGGM-RRDPAP 99
SP + R SR+ + + RR P+P
Sbjct: 2677 SPRKPIDSLRDSRSLSYSPVERRRPSP 2703
Score = 42.4 bits (98), Expect = 0.002
Identities = 82/359 (22%), Positives = 127/359 (35%), Gaps = 47/359 (13%)
Query: 530 SLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRD-- 587
SLTS ++ LS + P R + L +R R+ PP S +
Sbjct: 2365 SLTS-ARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSER 2423
Query: 588 --SPHS---ERYVSALTTPAR---LSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPI 639
SP S + +L PA+ SPV +S ++ + T + ++S A
Sbjct: 2424 APSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATT 2483
Query: 640 SYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSL 699
+ + +L PAP P G P Q S + PA RR + + S
Sbjct: 2484 TSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAK---ERRSSSSSSSSS 2540
Query: 700 GSLPASPFR------------------IPEDDEYETTQECAPPP----------PPRPRA 731
S +S +P E + +P P PP P
Sbjct: 2541 SSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTP 2600
Query: 732 RGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALA 791
RR+S+ S + ++ + ++ S S SS S S+S+S A AL
Sbjct: 2601 AKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALP 2660
Query: 792 AESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPPRAKQDSA 850
++P G + RS P+ DSR+ S+S R S P PR +Q S+
Sbjct: 2661 KPASPKKPPPGERRS-RSPRKPIDSLRDSRSL----SYSPVERRRPSPQPSPRDQQSSS 2714
Score = 42.0 bits (97), Expect = 0.002
Identities = 34/100 (34%), Positives = 40/100 (40%), Gaps = 8/100 (8%)
Query: 11 PPPLEKGRCSSYSDSSSSSSERSS--------SSSSSSSESGSSSRSSSNNSSISRPAAP 62
P K R S S S+SSS E S S S SS E SRSS S S P
Sbjct: 1695 PELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTK 1754
Query: 63 PEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFS 102
R + P P+ +R+ +RSR RR G S
Sbjct: 1755 TTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSS 1794
Score = 42.0 bits (97), Expect = 0.002
Identities = 43/153 (28%), Positives = 59/153 (38%)
Query: 10 PPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQ 69
PP + S+ + + RSSSSSSSSS S SSS SSS++SS S ++
Sbjct: 2509 PPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSL 2568
Query: 70 QPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSVQDQAYKAPV 129
QP R + A R P P + S + S S S + +
Sbjct: 2569 PVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSS 2628
Query: 130 VVEGKVQGLVPAGGSSSNSTREPPASGRVALVK 162
+ SSS+S+ P G AL K
Sbjct: 2629 SSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPK 2661
Score = 40.4 bits (93), Expect = 0.007
Identities = 47/187 (25%), Positives = 65/187 (34%), Gaps = 41/187 (21%)
Query: 8 ALPPPPLEKGRCSSYSDSSSS----SSERSSSSSSSSSES------GSSSRSSSNNSSIS 57
ALP P + R S + ++ ERS S SS ++ G SRS S+
Sbjct: 1488 ALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDV 1547
Query: 58 RPAAPPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSL 117
+P+A P+ R + P S A R R R+ + D S S S
Sbjct: 1548 KPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLS------PRRSRSGSS 1601
Query: 118 KSVQDQAYKAPVVVEG-------------------------KVQGLVPAGGSSSNSTREP 152
V+D+ AP G K +G P G SS+ S+ E
Sbjct: 1602 PEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEH 1661
Query: 153 PASGRVA 159
P R A
Sbjct: 1662 PPKSRTA 1668
Score = 35.0 bits (79), Expect = 0.29
Identities = 26/90 (28%), Positives = 37/90 (41%), Gaps = 1/90 (1%)
Query: 11 PPPLEKGRCSSYSDSSSSSSERSSSSS-SSSSESGSSSRSSSNNSSISRPAAPPEPRPQQ 69
P P K R SS SS E + + S S S SSS + + + +P P+
Sbjct: 1676 PEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEP 1735
Query: 70 QPQPRSPAARRAAARSRAAAAGGMRRDPAP 99
+ RS RR+A+ R R P+P
Sbjct: 1736 AEKSRSSRRRRSASSPRTKTTSRRGRSPSP 1765
Score = 34.7 bits (78), Expect = 0.39
Identities = 25/72 (34%), Positives = 27/72 (37%), Gaps = 5/72 (6%)
Query: 10 PPPPLEKGRCSSYSD-----SSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPE 64
P L R SYS S S R SSSS S R S + S R P
Sbjct: 2681 PIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPS 2740
Query: 65 PRPQQQPQPRSP 76
PRP + RSP
Sbjct: 2741 PRPMRHRSSRSP 2752
Score = 33.9 bits (76), Expect = 0.66
Identities = 24/86 (27%), Positives = 37/86 (43%), Gaps = 9/86 (10%)
Query: 23 SDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPRSPAAR--- 79
S S SSS R S SSS S + ++ + PEP+ + + PR ++R
Sbjct: 1636 SRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSP 1695
Query: 80 ------RAAARSRAAAAGGMRRDPAP 99
R + RSR+A++ R P
Sbjct: 1696 ELTRKARLSRRSRSASSSPETRSRTP 1721
Score = 33.1 bits (74), Expect = 1.1
Identities = 26/89 (29%), Positives = 37/89 (41%), Gaps = 2/89 (2%)
Query: 13 PLEKGRCSSYSDSSSSSSERSSSSSSSSSESGS--SSRSSSNNSSISRPAAPPEPRPQQQ 70
P +GR S + + S RS S S S + S RS S + + P + +
Sbjct: 609 PARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGR 668
Query: 71 PQPRSPAARRAAARSRAAAAGGMRRDPAP 99
+ R+PA R +RSR A G R P
Sbjct: 669 SRSRTPARRSGRSRSRTPARRGRSRSRTP 697
Score = 33.1 bits (74), Expect = 1.1
Identities = 27/83 (32%), Positives = 38/83 (45%), Gaps = 8/83 (9%)
Query: 25 SSSSSSERSSSSSSSSSESGSSSRS------SSNNSSISRPAAPPEPRPQ-QQPQPRSPA 77
+S SSS+RS S++ ++ + S SR+ SS S SRP+ P P + + P P
Sbjct: 2080 ASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPL 2139
Query: 78 ARRAAARSRAAAAGGMRRD-PAP 99
S AGG D P P
Sbjct: 2140 GSSRTPMSVLQQAGGSMMDGPGP 2162
Score = 32.7 bits (73), Expect = 1.5
Identities = 22/79 (27%), Positives = 32/79 (40%), Gaps = 8/79 (10%)
Query: 24 DSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQ--------PQPRS 75
D S+ S SSS S S+N SIS P PR + P+ +
Sbjct: 1370 DMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKD 1429
Query: 76 PAARRAAARSRAAAAGGMR 94
R + RSR+ ++ G+R
Sbjct: 1430 GLPRTPSRRSRSGSSPGLR 1448
Score = 32.3 bits (72), Expect = 1.9
Identities = 81/378 (21%), Positives = 122/378 (32%), Gaps = 85/378 (22%)
Query: 478 KNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESH--------TWSLERSE 529
K++P T R E ++ SP TP R S T ERS
Sbjct: 1467 KDIPRTPSRGRSECDS--------SPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSG 1518
Query: 530 SLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSP 589
S +S Q + + +G R+R ++ L+ + A+ P DS DS
Sbjct: 1519 SESSVDQKTVARTPLGQ-----------RSRSGSSQELDVKPSAS-PQERSESDSSPDSK 1566
Query: 590 HSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPL 649
R + + SP +V + SP + + S P + +P
Sbjct: 1567 AKTRTPLRQRSRSGSSP---------EVDSKSRLSPRRSRSGSSPEV--------KDKPR 1609
Query: 650 LRHPAPPGPGPGPGP-GPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFR 708
A G P P P P A +RS GP P + S +SP
Sbjct: 1610 AAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSS--------STESSPEH 1661
Query: 709 IPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLS 768
P+ +P P + R R + + P R++RL ++R+R+A S
Sbjct: 1662 PPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARL----SRRSRSASSSPETR 1717
Query: 769 SGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDS 828
S TP R S P + SR S S
Sbjct: 1718 S------------------------RTP---PRHRRSPSVSSPEPAEKSRSSRRRRSASS 1750
Query: 829 HSTRASSRHSRGPPPRAK 846
T+ +SR R P P+ +
Sbjct: 1751 PRTKTTSRRGRSPSPKPR 1768
Score = 31.6 bits (70), Expect = 3.3
Identities = 20/77 (25%), Positives = 34/77 (44%)
Query: 18 RCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPRSPA 77
R + +SS +SS R S + S SRS ++ + R + P ++ + R+P
Sbjct: 1823 RSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPL 1882
Query: 78 ARRAAARSRAAAAGGMR 94
R +RSR + R
Sbjct: 1883 ISRRRSRSRTSPVSRRR 1899
Score = 31.6 bits (70), Expect = 3.3
Identities = 26/79 (32%), Positives = 36/79 (45%), Gaps = 10/79 (12%)
Query: 18 RCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPR----------P 67
R S S +S + RS S +S + S SR+S SR PP R P
Sbjct: 1979 RRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLP 2038
Query: 68 QQQPQPRSPAARRAAARSR 86
+++ + RSP A R +RSR
Sbjct: 2039 RKRSRSRSPLAIRRRSRSR 2057
Score = 31.6 bits (70), Expect = 3.3
Identities = 35/126 (27%), Positives = 47/126 (37%), Gaps = 21/126 (16%)
Query: 32 RSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPRSPAARRAAARSRAAAAG 91
RS + S+ S+S +S + + SS A P Q QPRSP + +SR A
Sbjct: 2406 RSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIA- 2464
Query: 92 GMRRDPAPGFSMLLFGVSLACYSPSLKSVQDQAYKAPVVVEGKVQGL--VPAGGSSSNST 149
+ P G L G S + G G+ VPA G +
Sbjct: 2465 --QTTPVAGSQSLSSGAVATTTSSA----------------GDHNGMLSVPAPGVPHSDV 2506
Query: 150 REPPAS 155
EPPAS
Sbjct: 2507 GEPPAS 2512
Score = 31.2 bits (69), Expect = 4.3
Identities = 25/84 (29%), Positives = 35/84 (41%), Gaps = 7/84 (8%)
Query: 2 RQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAA 61
R+ C + P P L+ S +S S SS SS+ S S SSS + IS
Sbjct: 869 RRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIIS---- 924
Query: 62 PPEPRPQQQPQPRSPAARRAAARS 85
PR + SP+ R +R+
Sbjct: 925 ---PRQRSHSGSSSPSPSRVTSRT 945
Score = 30.8 bits (68), Expect = 5.6
Identities = 39/160 (24%), Positives = 66/160 (41%), Gaps = 10/160 (6%)
Query: 1 MRQVCCSALPPPPLEKGRCSS----YSDSSSSSSERSSSSSS--SSSESGSSSRSSSNNS 54
+R+ S P P +K + S+SSS ER SS SES S R + +
Sbjct: 174 VRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPT 233
Query: 55 SISRPAAPPEPRPQQQPQPRSPAARRA--AARSRAAAAGGMRRDPAPGFSMLLFGVSLAC 112
S+ + + R + + +P +RRA + + +A++ R + + +LA
Sbjct: 234 PKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAG 293
Query: 113 YSPSLKSVQDQAYKAPVVVEGKVQGLVPAGGSSSNSTREP 152
SPS S + AP G P+ S +T++P
Sbjct: 294 RSPSPASGRRGEGDAPFSEPGTTSTQRPS--SPETATKQP 331
Score = 30.8 bits (68), Expect = 5.6
Identities = 94/440 (21%), Positives = 145/440 (32%), Gaps = 71/440 (16%)
Query: 431 KTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRRE 490
K KK R + + R++ P P R ++ + + P + R
Sbjct: 214 KKKKHRSESESKKRKHRSPT---------PKSKRKSKDKKRKRSRSTTPAPKSRRA-HRS 263
Query: 491 TETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLE-RSESLTSD--SQSGIMLSSVGTS 547
T + S S S S A T HT +L RS S S + S GT+
Sbjct: 264 TSADSASSSDTSRSRSRSAAAKT-------HTTALAGRSPSPASGRRGEGDAPFSEPGTT 316
Query: 548 KCNSPACVEARARRAAA-YNLEER----RRATAPPYHDSVDSLRDSPHS------ERYVS 596
P+ E ++ ++ Y +++ + AT P S P + ER+
Sbjct: 317 STQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGG 376
Query: 597 A----LTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRH 652
+ TTP PV+ + PT + + P S + ++ S + + RH
Sbjct: 377 SPQPLATTPLSQEPVN---PPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRH 433
Query: 653 PAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPF---RI 709
+ P P P PG ++ S S G S P+ R
Sbjct: 434 ASSSPESPKPAPAPGSHREISSSPTS-------KNRSHGRAKRDKSHSHTPSRRMGRSRS 486
Query: 710 PEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARD------ 763
P + ++ P R+R R S +RW RSR + QR +R
Sbjct: 487 PATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSR----SPQRRGRSRSPQRPGW 542
Query: 764 SLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTY 823
S S ++ G S SA + A S RS +P + SRT
Sbjct: 543 SRSRNTQRRGRSRSARRGRSHSRSPATRGRS-------------RSRTPARRGRSRSRTP 589
Query: 824 YSLDSHSTRASSRHSRGPPP 843
S S + R SR P
Sbjct: 590 ARRRSRSRTPTRRRSRSRTP 609
Score = 30.4 bits (67), Expect = 7.3
Identities = 26/88 (29%), Positives = 43/88 (48%), Gaps = 3/88 (3%)
Query: 13 PLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRP-QQQP 71
P +GR S + + S RS + + S S + +R S + + +R P +++
Sbjct: 567 PATRGRSRSRTPARRGRS-RSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRS 625
Query: 72 QPRSPAARRAAARSRAAAAGGMR-RDPA 98
+ RSP RR+ +RS A +G R R PA
Sbjct: 626 RTRSPVRRRSRSRSPARRSGRSRSRTPA 653
>gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]
Length = 296
Score = 60.8 bits (146), Expect = 5e-09
Identities = 25/61 (40%), Positives = 40/61 (65%), Gaps = 3/61 (4%)
Query: 332 STTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVN 388
++T ++ + H KC E K++CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +
Sbjct: 224 TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMAS 283
Query: 389 F 389
F
Sbjct: 284 F 284
>gi|93102361 palladin [Homo sapiens]
Length = 1106
Score = 60.5 bits (145), Expect = 7e-09
Identities = 33/96 (34%), Positives = 51/96 (53%), Gaps = 2/96 (2%)
Query: 239 LKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQF 298
++K++SQ G + L+C GNP P RWF +GKEL+ + DI+I G ++ L
Sbjct: 274 IQKLRSQEVAEGSRVYLECRVT-GNPTPRVRWFCEGKELHNTPDIQIHCEGGDLHT-LII 331
Query: 299 NKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTT 334
+ +D G Y C A N G DT +++ S+T
Sbjct: 332 AEAFEDDTGRYTCLATNPSGSDTTSAEVFIEGASST 367
Score = 43.9 bits (102), Expect = 6e-04
Identities = 31/114 (27%), Positives = 47/114 (41%), Gaps = 7/114 (6%)
Query: 240 KKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSR---- 295
K++++ G+ L+C G P +WF+ G E+ S D RI R +
Sbjct: 445 KELQNTAVAEGQVVVLECRVR-GAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAEPEEI 503
Query: 296 --LQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNE 347
L + EDAG + C A N G T +L V S +T S+ N+
Sbjct: 504 CTLVIAETFPEDAGIFTCSARNDYGSATSTAQLVVTSANTENCSYESMGESNND 557
Score = 43.5 bits (101), Expect = 8e-04
Identities = 24/72 (33%), Positives = 35/72 (48%)
Query: 261 AGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKD 320
AGNP+P WFKDGK+++ D + L ++D G Y A N G+
Sbjct: 801 AGNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANPQGRI 860
Query: 321 TVRGRLYVNSVS 332
+ GRL V +V+
Sbjct: 861 SCTGRLMVQAVN 872
>gi|10864029 junctional adhesion molecule 2 precursor [Homo sapiens]
Length = 298
Score = 58.2 bits (139), Expect = 3e-08
Identities = 31/74 (41%), Positives = 35/74 (47%), Gaps = 5/74 (6%)
Query: 250 GEKQSLKCEAAAGNPQPSYRWFKDGKELNR-----SRDIRIKYGNGRKNSRLQFNKVKVE 304
G L+C+ GNP P Y WFKDG L S+ Y K LQFN V
Sbjct: 148 GTVVELRCQDKEGNPAPEYTWFKDGIRLLENPRLGSQSTNSSYTMNTKTGTLQFNTVSKL 207
Query: 305 DAGEYVCEAENILG 318
D GEY CEA N +G
Sbjct: 208 DTGEYSCEARNSVG 221
>gi|153792294 myopalladin [Homo sapiens]
Length = 1320
Score = 58.2 bits (139), Expect = 3e-08
Identities = 35/111 (31%), Positives = 51/111 (45%), Gaps = 3/111 (2%)
Query: 240 KKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFN 299
+K++S+ G + L C G P P RW+ +GKEL S DI I + L
Sbjct: 273 QKLRSREVPEGTRVQLDC-IVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHS--LTIA 329
Query: 300 KVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAK 350
+ ED G Y C A NI G D+ +Y+ VS++ S + + N K
Sbjct: 330 EAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQK 380
Score = 40.4 bits (93), Expect = 0.007
Identities = 32/145 (22%), Positives = 57/145 (39%), Gaps = 3/145 (2%)
Query: 187 PLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLKKMKSQT 246
P ++ + F + + F+ P+D + ++ + +I C K++K
Sbjct: 898 PNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHD--EIPTGKCIAPIFDKRLKHFR 955
Query: 247 GQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDA 306
G + C+ G P P WFKDGK++++ + G L +D
Sbjct: 956 VTEGSPVTFTCKIV-GIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD 1014
Query: 307 GEYVCEAENILGKDTVRGRLYVNSV 331
G Y A N G+ + G L V S+
Sbjct: 1015 GNYTIMAANPQGRISCSGHLMVQSL 1039
Score = 36.2 bits (82), Expect = 0.13
Identities = 26/109 (23%), Positives = 46/109 (42%), Gaps = 7/109 (6%)
Query: 240 KKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSR---- 295
K +++ + G+ +C G P P W+++G + S D RI R +
Sbjct: 439 KMLQNLSASEGQLVVFECRVK-GAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEI 497
Query: 296 --LQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHA 342
L +V ED+G + C A N G + +L+V ++ S H+
Sbjct: 498 CTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHS 546
>gi|153792780 additional sex combs like 2 [Homo sapiens]
Length = 1435
Score = 56.6 bits (135), Expect = 9e-08
Identities = 86/372 (23%), Positives = 136/372 (36%), Gaps = 59/372 (15%)
Query: 420 VVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAH-QNRSLANGPSHPRLDP--EEIQMADYI 476
++ IV VV+ + K++ QM + R+ C + + + + S P L +++ +
Sbjct: 419 LIRIVPVVSQSECKEEALQMSSPGRKEECESQGEVQPNFSTSSEPLLSSALNTHELSSIL 478
Query: 477 SKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSES------ 530
P + ++ ++ T S +H + + S ES S + +S
Sbjct: 479 PIKCPKDEDLLEQKPVT--SAEQESEKNHLTTASNYNKSESQESLVTSPSKPKSPGVEKP 536
Query: 531 -----LTSDSQSGIMLSSVGTSKCNSPACVEARA---RRAAAYNLEERRRATAPPYHDSV 582
+ Q M + T SP ++ ++ + A + E+R R T H
Sbjct: 537 IVKPTAGAGPQETNMKEPLATLVDQSPESLKRKSSLTQEEAPVSWEKRPRVTENRQHQQP 596
Query: 583 DSLRDSPHSER-------YVSALTTP-ARLSPVDFHYSLATQVPTF--EITSPNSAHAVS 632
+ P R V L P +R+SP+ FH S + F ITSPN A +
Sbjct: 597 FQVSPQPFLNRGDRIQVRKVPPLKIPVSRISPMPFHPSQVSPRARFPVSITSPNRTGART 656
Query: 633 LPPAAPISYRLAEQQPLLRHPAP-----------PGPGPGPGPGPGPGADMQR----SYD 677
L + + Q+ A PGPGPG G GPG G + Q S
Sbjct: 657 LADIKAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGEGQTARGGSPG 716
Query: 678 SYYYPAAGPGPR---RGTCALGGSLGSLPASPFRIPEDDEYETTQEC------------A 722
S G GP GT + GG+ LP P P+ + T +
Sbjct: 717 SDRVSETGKGPTLELAGTGSRGGTRELLPCGPETQPQSETKTTPSQAQPHSVSGAQLQQT 776
Query: 723 PPPPPRPRARGA 734
PP PP P GA
Sbjct: 777 PPVPPTPAVSGA 788
Score = 35.8 bits (81), Expect = 0.17
Identities = 36/149 (24%), Positives = 56/149 (37%), Gaps = 16/149 (10%)
Query: 9 LPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQ 68
+PP P G C+S + +E + +R+++ +S+S P P R +
Sbjct: 779 VPPTPAVSGACTSVPSPAHIEK--------LDNEKLNPTRATATVASVSHPQGPSSCRQE 830
Query: 69 QQPQPRSPAARRAAARSRAAA-------AGGMRRDPAPGFSMLLFGVSLACYSPS-LKSV 120
+ P P PA A+ AA AG + P P S +PS L S+
Sbjct: 831 KAPSPTGPALISGASPVHCAADGTVELKAGPSKNIPNPSASSKTDASVPVAVTPSPLTSL 890
Query: 121 QDQAYKAPVVVEGKVQGLVPAGGSSSNST 149
A + V PAG + +ST
Sbjct: 891 LTTATLEKLPVPQVSATTAPAGSAPPSST 919
Score = 30.4 bits (67), Expect = 7.3
Identities = 21/47 (44%), Positives = 24/47 (51%), Gaps = 1/47 (2%)
Query: 20 SSYSDSSSSSSERSSSSS-SSSSESGSSSRSSSNNSSISRPAAPPEP 65
SS S S SSE SSSSS S++ G SR SS S + P P
Sbjct: 101 SSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKRKVSSSSPQSGCPSP 147
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 56.2 bits (134), Expect = 1e-07
Identities = 27/78 (34%), Positives = 46/78 (58%), Gaps = 7/78 (8%)
Query: 344 KCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEEL 403
+C + YC++ GVC YIE +++ +C C VGY G+RCQ + +EL+ A
Sbjct: 975 ECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQ------YRDLKWWELRHAGHG 1028
Query: 404 YQKRVLTITGICVALLVV 421
Q++V+ + +CV +LV+
Sbjct: 1029 QQQKVI-VVAVCVVVLVM 1045
>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
Length = 2968
Score = 55.8 bits (133), Expect = 2e-07
Identities = 46/132 (34%), Positives = 59/132 (44%), Gaps = 14/132 (10%)
Query: 20 SSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPRSPAAR 79
SS S SSSSSS SSSSSSSSS S SSS SSS++SS + + + P P + +
Sbjct: 2636 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGPSA 2695
Query: 80 RAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSVQDQAYKAPVVVEGKVQGLV 139
+AA ++A G R A +SP K+ Q P +Q
Sbjct: 2696 QAALPTKATKQAGKARPSA--------------HSPGKKTPAPQPQAPPPQPTQPLQPKA 2741
Query: 140 PAGGSSSNSTRE 151
AG S RE
Sbjct: 2742 QAGAKSRPKKRE 2753
Score = 40.8 bits (94), Expect = 0.005
Identities = 26/73 (35%), Positives = 41/73 (56%)
Query: 17 GRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPRSP 76
GR S + S ++S SSSSSSSSS S SSS SSS++SS S ++ S
Sbjct: 2599 GRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2658
Query: 77 AARRAAARSRAAA 89
++ +++ S +++
Sbjct: 2659 SSSSSSSSSSSSS 2671
Score = 38.9 bits (89), Expect = 0.020
Identities = 22/74 (29%), Positives = 42/74 (56%)
Query: 17 GRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPRSP 76
G C + + S++S R++S +SSSS S SSS SSS++SS S ++ S
Sbjct: 2593 GGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2652
Query: 77 AARRAAARSRAAAA 90
++ +++ S ++++
Sbjct: 2653 SSSSSSSSSSSSSS 2666
Score = 35.4 bits (80), Expect = 0.23
Identities = 27/83 (32%), Positives = 39/83 (46%), Gaps = 15/83 (18%)
Query: 23 SDSSSSSSERSSSSSSSSSESGSSSRSSS---------------NNSSISRPAAPPEPRP 67
S+SSSSSS SSSSSSSSS SGS + N S+ S AA P
Sbjct: 2557 SESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSS 2616
Query: 68 QQQPQPRSPAARRAAARSRAAAA 90
S ++ +++ S ++++
Sbjct: 2617 SSSSSSSSSSSSSSSSSSSSSSS 2639
Score = 34.7 bits (78), Expect = 0.39
Identities = 56/249 (22%), Positives = 84/249 (33%), Gaps = 19/249 (7%)
Query: 615 TQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQR 674
T P E + A A SL PA I+ +P A GP PG A++
Sbjct: 2404 TSCPAPEPFAELPAPATSLAPAPLITMPATRPKPKKARAAEESGAKGPRR-PGEEAELLV 2462
Query: 675 SYDSYYYPAAGPGPRRGTCAL------GGSLGSLPASPFRIPEDDEYETTQECAPPPPPR 728
D + P ++ AL G P S + Y + P P
Sbjct: 2463 KLD--HEGVTSPKSKKAKEALLLREDPGAGGWQEPKSLLSL---GSYPPAAGSSEPKAPW 2517
Query: 729 PRARGASRRTSAGPRRWRRSRLNGLAAQRARAARD------SLSLSSGSGGGSASASDDD 782
P+A GP N + +A+A +D S S SS S+S+S
Sbjct: 2518 PKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSS 2577
Query: 783 ADDADGALAAESTPFLGL-RGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGP 841
+ +G + G G + + S PA+ S + S S S+ +SS S
Sbjct: 2578 GSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSS 2637
Query: 842 PPRAKQDSA 850
+ S+
Sbjct: 2638 SSSSSSSSS 2646
Score = 34.7 bits (78), Expect = 0.39
Identities = 38/142 (26%), Positives = 54/142 (38%), Gaps = 1/142 (0%)
Query: 15 EKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPR 74
+ G S + + S SSSSS SGSSS SSS++SS S E
Sbjct: 2537 DSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCG 2596
Query: 75 SPAARRAAARSRAAA-AGGMRRDPAPGFSMLLFGVSLACYSPSLKSVQDQAYKAPVVVEG 133
+ +AA SRAA+ A + S S + S S S + +
Sbjct: 2597 TGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2656
Query: 134 KVQGLVPAGGSSSNSTREPPAS 155
+ SSS+ST + +S
Sbjct: 2657 SSSSSSSSSSSSSSSTTDEDSS 2678
Score = 31.2 bits (69), Expect = 4.3
Identities = 17/39 (43%), Positives = 20/39 (51%)
Query: 13 PLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSS 51
P + + D + S SSSSS SSS S SSS S S
Sbjct: 2541 PKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGS 2579
Score = 30.4 bits (67), Expect = 7.3
Identities = 18/41 (43%), Positives = 21/41 (51%)
Query: 11 PPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSS 51
P +K + S SS SSS SSSSS S SSS S +
Sbjct: 2541 PKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSET 2581
Score = 30.0 bits (66), Expect = 9.5
Identities = 34/114 (29%), Positives = 48/114 (42%), Gaps = 17/114 (14%)
Query: 7 SALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPR 66
+ LP GR + S++ S +S+ S SGS +R ++ RP +
Sbjct: 556 AVLPRSAATCGRPVADMHSAAHGSGEASAMQSLIKYSGSFAR----DAVAVRPGGCGKKS 611
Query: 67 P-------QQQPQPRSPAARRAAAR---SRAAAAGG---MRRDPAPGFSMLLFG 107
P + +P P S A RA AR S AAGG ++RDP S FG
Sbjct: 612 PFGGLGTMKPEPAPTSAGASRAQARLPHSGGPAAGGGRQLKRDPERPESAKAFG 665
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 55.1 bits (131), Expect = 3e-07
Identities = 29/77 (37%), Positives = 42/77 (54%), Gaps = 5/77 (6%)
Query: 242 MKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKV 301
+++QT +GE + C A+GNP P WFKD + L I +K G N L +V
Sbjct: 673 LENQTTSIGESIEVSC-TASGNPPPQIMWFKDNETLVEDSGIVLKDG----NRNLTIRRV 727
Query: 302 KVEDAGEYVCEAENILG 318
+ ED G Y C+A ++LG
Sbjct: 728 RKEDEGLYTCQACSVLG 744
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,807,439
Number of Sequences: 37866
Number of extensions: 2425372
Number of successful extensions: 39250
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 647
Number of HSP's successfully gapped in prelim test: 1297
Number of HSP's that attempted gapping in prelim test: 21776
Number of HSP's gapped (non-prelim): 13062
length of query: 852
length of database: 18,247,518
effective HSP length: 111
effective length of query: 741
effective length of database: 14,044,392
effective search space: 10406894472
effective search space used: 10406894472
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.