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Search of human proteins with 7669528
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
(844 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens] 1714 0.0
gi|7669532 neuregulin 2 isoform 4 [Homo sapiens] 1707 0.0
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens] 1679 0.0
gi|7669530 neuregulin 2 isoform 3 [Homo sapiens] 1676 0.0
gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens] 377 e-104
gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens] 375 e-104
gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens] 372 e-103
gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens] 365 e-101
gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens] 365 e-101
gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens] 358 1e-98
gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens] 285 2e-76
gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens] 284 3e-76
gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens] 270 3e-72
gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens] 221 2e-57
gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens] 196 8e-50
gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens] 122 1e-27
gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens] 110 5e-24
gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens] 97 5e-20
gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens] 96 2e-19
gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens] 86 2e-16
gi|66730481 neuregulin 3 [Homo sapiens] 78 4e-14
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 65 3e-10
gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens] 61 5e-09
gi|93102361 palladin [Homo sapiens] 60 6e-09
gi|10864029 junctional adhesion molecule 2 precursor [Homo sapiens] 58 3e-08
gi|153792294 myopalladin [Homo sapiens] 58 3e-08
gi|153792780 additional sex combs like 2 [Homo sapiens] 57 9e-08
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 56 2e-07
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 55 3e-07
gi|110349719 titin isoform N2-A [Homo sapiens] 54 5e-07
>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
Length = 844
Score = 1714 bits (4439), Expect = 0.0
Identities = 844/844 (100%), Positives = 844/844 (100%)
Query: 1 MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA 60
MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA
Sbjct: 1 MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA 60
Query: 61 APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV 120
APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV
Sbjct: 61 APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV 120
Query: 121 QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI 180
QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI
Sbjct: 121 QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI 180
Query: 181 SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK 240
SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK
Sbjct: 181 SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK 240
Query: 241 KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK 300
KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK
Sbjct: 241 KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK 300
Query: 301 VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY 360
VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY
Sbjct: 301 VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY 360
Query: 361 YIEGINQLSCKCPVGYTGDRCQQFAMVNFSKAEELYQKRVLTITGICVALLVVGIVCVVA 420
YIEGINQLSCKCPVGYTGDRCQQFAMVNFSKAEELYQKRVLTITGICVALLVVGIVCVVA
Sbjct: 361 YIEGINQLSCKCPVGYTGDRCQQFAMVNFSKAEELYQKRVLTITGICVALLVVGIVCVVA 420
Query: 421 YCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIR 480
YCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIR
Sbjct: 421 YCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIR 480
Query: 481 RETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSK 540
RETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSK
Sbjct: 481 RETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSK 540
Query: 541 CNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVD 600
CNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVD
Sbjct: 541 CNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVD 600
Query: 601 FHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGP 660
FHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGP
Sbjct: 601 FHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGP 660
Query: 661 GADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPR 720
GADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPR
Sbjct: 661 GADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPR 720
Query: 721 PRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADG 780
PRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADG
Sbjct: 721 PRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADG 780
Query: 781 ALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPPRAKQD 840
ALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPPRAKQD
Sbjct: 781 ALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPPRAKQD 840
Query: 841 SAPL 844
SAPL
Sbjct: 841 SAPL 844
>gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
Length = 852
Score = 1707 bits (4420), Expect = 0.0
Identities = 844/852 (99%), Positives = 844/852 (99%), Gaps = 8/852 (0%)
Query: 1 MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA 60
MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA
Sbjct: 1 MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA 60
Query: 61 APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV 120
APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV
Sbjct: 61 APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV 120
Query: 121 QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI 180
QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI
Sbjct: 121 QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI 180
Query: 181 SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK 240
SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK
Sbjct: 181 SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK 240
Query: 241 KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK 300
KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK
Sbjct: 241 KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK 300
Query: 301 VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY 360
VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY
Sbjct: 301 VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY 360
Query: 361 YIEGINQLSCKCPVGYTGDRCQQFAMVNFSK--------AEELYQKRVLTITGICVALLV 412
YIEGINQLSCKCPVGYTGDRCQQFAMVNFSK AEELYQKRVLTITGICVALLV
Sbjct: 361 YIEGINQLSCKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRVLTITGICVALLV 420
Query: 413 VGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNV 472
VGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNV
Sbjct: 421 VGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNV 480
Query: 473 PATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIM 532
PATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIM
Sbjct: 481 PATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIM 540
Query: 533 LSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTT 592
LSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTT
Sbjct: 541 LSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTT 600
Query: 593 PARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGP 652
PARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGP
Sbjct: 601 PARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGP 660
Query: 653 GPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQE 712
GPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQE
Sbjct: 661 GPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQE 720
Query: 713 CAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASD 772
CAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASD
Sbjct: 721 CAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASD 780
Query: 773 DDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRG 832
DDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRG
Sbjct: 781 DDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRG 840
Query: 833 PPPRAKQDSAPL 844
PPPRAKQDSAPL
Sbjct: 841 PPPRAKQDSAPL 852
>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
Length = 850
Score = 1679 bits (4348), Expect = 0.0
Identities = 831/850 (97%), Positives = 834/850 (98%), Gaps = 6/850 (0%)
Query: 1 MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA 60
MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA
Sbjct: 1 MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA 60
Query: 61 APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV 120
APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV
Sbjct: 61 APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV 120
Query: 121 QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI 180
QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI
Sbjct: 121 QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI 180
Query: 181 SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK 240
SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK
Sbjct: 181 SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK 240
Query: 241 KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK 300
KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK
Sbjct: 241 KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK 300
Query: 301 VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY 360
VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY
Sbjct: 301 VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY 360
Query: 361 YIEGINQLSCKCPVGYTGDRCQQFAMVNF------SKAEELYQKRVLTITGICVALLVVG 414
YIEGINQLSCKCP G+ G RC + + KAEELYQKRVLTITGICVALLVVG
Sbjct: 361 YIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKAEELYQKRVLTITGICVALLVVG 420
Query: 415 IVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPA 474
IVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPA
Sbjct: 421 IVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPA 480
Query: 475 TDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLS 534
TDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLS
Sbjct: 481 TDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLS 540
Query: 535 SVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPA 594
SVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPA
Sbjct: 541 SVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPA 600
Query: 595 RLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGP 654
RLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGP
Sbjct: 601 RLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGP 660
Query: 655 GPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECA 714
GPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECA
Sbjct: 661 GPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECA 720
Query: 715 PPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDD 774
PPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDD
Sbjct: 721 PPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDD 780
Query: 775 ADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPP 834
ADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPP
Sbjct: 781 ADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPP 840
Query: 835 PRAKQDSAPL 844
PRAKQDSAPL
Sbjct: 841 PRAKQDSAPL 850
>gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]
Length = 858
Score = 1676 bits (4341), Expect = 0.0
Identities = 831/858 (96%), Positives = 834/858 (97%), Gaps = 14/858 (1%)
Query: 1 MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA 60
MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA
Sbjct: 1 MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA 60
Query: 61 APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV 120
APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV
Sbjct: 61 APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV 120
Query: 121 QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI 180
QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI
Sbjct: 121 QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI 180
Query: 181 SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK 240
SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK
Sbjct: 181 SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK 240
Query: 241 KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK 300
KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK
Sbjct: 241 KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK 300
Query: 301 VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY 360
VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY
Sbjct: 301 VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY 360
Query: 361 YIEGINQLSCKCPVGYTGDRC--------------QQFAMVNFSKAEELYQKRVLTITGI 406
YIEGINQLSCKCP G+ G RC Q+ +AEELYQKRVLTITGI
Sbjct: 361 YIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKHLGFELKEAEELYQKRVLTITGI 420
Query: 407 CVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMAD 466
CVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMAD
Sbjct: 421 CVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMAD 480
Query: 467 YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSD 526
YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSD
Sbjct: 481 YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSD 540
Query: 527 SQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERY 586
SQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERY
Sbjct: 541 SQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERY 600
Query: 587 VSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPA 646
VSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPA
Sbjct: 601 VSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPA 660
Query: 647 PPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDE 706
PPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDE
Sbjct: 661 PPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDE 720
Query: 707 YETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGG 766
YETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGG
Sbjct: 721 YETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGG 780
Query: 767 SASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRAS 826
SASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRAS
Sbjct: 781 SASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRAS 840
Query: 827 SRHSRGPPPRAKQDSAPL 844
SRHSRGPPPRAKQDSAPL
Sbjct: 841 SRHSRGPPPRAKQDSAPL 858
>gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]
Length = 590
Score = 377 bits (968), Expect = e-104
Identities = 243/613 (39%), Positives = 345/613 (56%), Gaps = 73/613 (11%)
Query: 222 KKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS- 280
K G++ T A P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR
Sbjct: 3 KGRAGRVGTT--ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
Query: 281 --RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSW 338
++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ + + + T +S
Sbjct: 61 KPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTST 118
Query: 339 SG--HARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNFSK-- 391
+G H KC E K++CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +F K
Sbjct: 119 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHL 178
Query: 392 ------AEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN 445
AEELYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N
Sbjct: 179 GIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNN 238
Query: 446 -RSLANGPSHPRLDPEEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTAT 503
++ANGP HP PE +Q+ + Y+SKNV +++H++ RE ET+FS SH S +HH +T T
Sbjct: 239 MMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVT 298
Query: 504 PTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERR 563
T SH+WS +ES+ S+S S I++SSV S+ +SP R R
Sbjct: 299 QT-----PSHSWSNGHTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPR 349
Query: 564 RATAPPYH--DSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAH 621
+ H ++ DS RDSPHSERYVSA+TTPAR+SPVDFH + + P E++ P S+
Sbjct: 350 ECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSM 409
Query: 622 AVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPR 681
VS+P A +S + E++PLL P P + + S+++ A
Sbjct: 410 TVSMPSMA-VSPFMEEERPLLLVTPPRLREKKFDHHP-------QQFSSFHHNPAHDS-- 459
Query: 682 RGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSR 741
SLPASP RI ED+EYETTQE P P + A RR +R++
Sbjct: 460 ----------NSLPASPLRIVEDEEYETTQEYEPAQEPVKKL--------ANSRRAKRTK 501
Query: 742 LNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRS 801
NG A R L + S + S+++ + D+ G E TPFLG++ A
Sbjct: 502 PNGHIANR-------LEVDSNTSSQSSNSESETEDERVG----EDTPFLGIQNPL-AASL 549
Query: 802 DSPPLCPAADSRT 814
++ P ADSRT
Sbjct: 550 EATPAFRLADSRT 562
>gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]
Length = 607
Score = 375 bits (963), Expect = e-104
Identities = 244/630 (38%), Positives = 348/630 (55%), Gaps = 90/630 (14%)
Query: 222 KKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS- 280
K G++ T A P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR
Sbjct: 3 KGRAGRVGTT--ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
Query: 281 --RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRL------------ 326
++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 61 KPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGM 118
Query: 327 -------YVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGY 376
YV+S ++T ++ + H KC E K++CVNGG C+ ++ ++ S CKCP +
Sbjct: 119 PASTEGAYVSSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEF 178
Query: 377 TGDRCQQFAMVNFSK--------AEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQR 428
TGDRCQ + M +F K AEELYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQR
Sbjct: 179 TGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQR 238
Query: 429 KQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQMAD-YISKNVPATDHVIRRETETT 486
K++H+ LRQ++ N ++ANGP HP PE +Q+ + Y+SKNV +++H++ RE ET+
Sbjct: 239 KKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETS 298
Query: 487 FSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPAC 546
FS SH S +HH +T T T SH+WS +ES+ S+S S I++SSV S+ +SP
Sbjct: 299 FSTSHYTSTAHHSTTVTQT-----PSHSWSNGHTESILSESHSVIVMSSVENSRHSSP-- 351
Query: 547 VEARARRAAAYNLEERRRATAPPYH--DSVDSLRDSPHSERYVSALTTPARLSPVDFHYS 604
R R + H ++ DS RDSPHSERYVSA+TTPAR+SPVDFH
Sbjct: 352 --TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTP 409
Query: 605 LATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADM 664
+ + P E++ P S+ VS+P A +S + E++PLL P P
Sbjct: 410 SSPKSPPSEMSPPVSSMTVSMPSMA-VSPFMEEERPLLLVTPPRLREKKFDHHP------ 462
Query: 665 QRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRAR 724
+ + S+++ A SLPASP RI ED+EYETTQE P P +
Sbjct: 463 -QQFSSFHHNPAHDS------------NSLPASPLRIVEDEEYETTQEYEPAQEPVKKL- 508
Query: 725 GASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAA 784
A RR +R++ NG A R L + S + S+++ + D+ G
Sbjct: 509 -------ANSRRAKRTKPNGHIANR-------LEVDSNTSSQSSNSESETEDERVG---- 550
Query: 785 ESTPFLGLRGAHDALRSDSPPLCPAADSRT 814
E TPFLG++ A ++ P ADSRT
Sbjct: 551 EDTPFLGIQNPL-AASLEATPAFRLADSRT 579
>gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]
Length = 637
Score = 372 bits (956), Expect = e-103
Identities = 248/650 (38%), Positives = 350/650 (53%), Gaps = 104/650 (16%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
+ N+ S+T +S +G H KC E K+
Sbjct: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
Query: 352 YCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNFSKAEELYQKRVLTITGICV 408
+CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +F KAEELYQKRVLTITGIC+
Sbjct: 189 FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICI 248
Query: 409 ALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQMAD- 466
ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP PE +Q+ +
Sbjct: 249 ALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQ 308
Query: 467 YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSD 526
Y+SKNV +++H++ RE ET+FS SH S +HH +T T T SH+WS +ES+ S+
Sbjct: 309 YVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNGHTESILSE 363
Query: 527 SQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDSLRDSPHSE 584
S S I++SSV S+ +SP R R + H ++ DS RDSPHSE
Sbjct: 364 SHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSE 419
Query: 585 RYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRH 644
RYVSA+TTPAR+SPVDFH + + P E++ P S+ VS+P A +S + E++PLL
Sbjct: 420 RYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMA-VSPFMEEERPLLLV 478
Query: 645 PAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPED 704
P P + + S+++ A SLPASP RI ED
Sbjct: 479 TPPRLREKKFDHHP-------QQFSSFHHNPAHDS------------NSLPASPLRIVED 519
Query: 705 DEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSG 764
+EYETTQE P P + A RR +R++ NG A R L + S +
Sbjct: 520 EEYETTQEYEPAQEPVKKL--------ANSRRAKRTKPNGHIANR-------LEVDSNTS 564
Query: 765 GGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT 814
S+++ + D+ G E TPFLG++ A ++ P ADSRT
Sbjct: 565 SQSSNSESETEDERVG----EDTPFLGIQNPL-AASLEATPAFRLADSRT 609
>gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]
Length = 624
Score = 365 bits (937), Expect = e-101
Identities = 245/647 (37%), Positives = 348/647 (53%), Gaps = 107/647 (16%)
Query: 222 KKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS- 280
K G++ T A P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR
Sbjct: 3 KGRAGRVGTT--ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
Query: 281 --RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV---------- 328
++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ + +
Sbjct: 61 KPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGM 118
Query: 329 ------------------------NSVSTTLSSWSG--HARKCNETAKSYCVNGGVCYYI 362
N+ S+T +S +G H KC E K++CVNGG C+ +
Sbjct: 119 PASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMV 178
Query: 363 EGINQLS---CKCPVGYTGDRCQQFAMVNFSK--------AEELYQKRVLTITGICVALL 411
+ ++ S CKCP +TGDRCQ + M +F K AEELYQKRVLTITGIC+ALL
Sbjct: 179 KDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALL 238
Query: 412 VVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQMAD-YIS 469
VVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP PE +Q+ + Y+S
Sbjct: 239 VVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVS 298
Query: 470 KNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQS 529
KNV +++H++ RE ET+FS SH S +HH +T T T SH+WS +ES+ S+S S
Sbjct: 299 KNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNGHTESILSESHS 353
Query: 530 GIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDSLRDSPHSERYV 587
I++SSV S+ +SP R R + H ++ DS RDSPHSERYV
Sbjct: 354 VIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYV 409
Query: 588 SALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAP 647
SA+TTPAR+SPVDFH + + P E++ P S+ VS+P A +S + E++PLL P
Sbjct: 410 SAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMA-VSPFMEEERPLLLVTPP 468
Query: 648 PGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEY 707
P + + S+++ A SLPASP RI ED+EY
Sbjct: 469 RLREKKFDHHP-------QQFSSFHHNPAHDS------------NSLPASPLRIVEDEEY 509
Query: 708 ETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGS 767
ETTQE P P + A RR +R++ NG A R L + S + S
Sbjct: 510 ETTQEYEPAQEPVKKL--------ANSRRAKRTKPNGHIANR-------LEVDSNTSSQS 554
Query: 768 ASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT 814
+++ + D+ G E TPFLG++ A ++ P ADSRT
Sbjct: 555 SNSESETEDERVG----EDTPFLGIQNPL-AASLEATPAFRLADSRT 596
>gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]
Length = 645
Score = 365 bits (937), Expect = e-101
Identities = 248/658 (37%), Positives = 350/658 (53%), Gaps = 112/658 (17%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
+ N+ S+T +S +G H KC E K+
Sbjct: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
Query: 352 YCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNFSK--------AEELYQKRV 400
+CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +F K AEELYQKRV
Sbjct: 189 FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRV 248
Query: 401 LTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDP 459
LTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP P
Sbjct: 249 LTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPP 308
Query: 460 EEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLE 518
E +Q+ + Y+SKNV +++H++ RE ET+FS SH S +HH +T T T SH+WS
Sbjct: 309 ENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNG 363
Query: 519 RSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDS 576
+ES+ S+S S I++SSV S+ +SP R R + H ++ DS
Sbjct: 364 HTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDS 419
Query: 577 LRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLA 636
RDSPHSERYVSA+TTPAR+SPVDFH + + P E++ P S+ VS+P A +S +
Sbjct: 420 YRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMA-VSPFME 478
Query: 637 EQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPA 696
E++PLL P P + + S+++ A SLPA
Sbjct: 479 EERPLLLVTPPRLREKKFDHHP-------QQFSSFHHNPAHDS------------NSLPA 519
Query: 697 SPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDS 756
SP RI ED+EYETTQE P P + A RR +R++ NG A R
Sbjct: 520 SPLRIVEDEEYETTQEYEPAQEPVKKL--------ANSRRAKRTKPNGHIANR------- 564
Query: 757 LSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT 814
L + S + S+++ + D+ G E TPFLG++ A ++ P ADSRT
Sbjct: 565 LEVDSNTSSQSSNSESETEDERVG----EDTPFLGIQNPL-AASLEATPAFRLADSRT 617
>gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]
Length = 640
Score = 358 bits (919), Expect = 1e-98
Identities = 245/653 (37%), Positives = 347/653 (53%), Gaps = 107/653 (16%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
+ N+ S+T +S +G H KC E K+
Sbjct: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
Query: 352 YCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQ---FAMVNFSKAEELYQKRVLTITG 405
+CVNGG C+ ++ ++ S CKC G+TG RC + + N KAEELYQKRVLTITG
Sbjct: 189 FCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITG 248
Query: 406 ICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQM 464
IC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP PE +Q+
Sbjct: 249 ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQL 308
Query: 465 AD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESL 523
+ Y+SKNV +++H++ RE ET+FS SH S +HH +T T T SH+WS +ES+
Sbjct: 309 VNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNGHTESI 363
Query: 524 TSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDSLRDSP 581
S+S S I++SSV S+ +SP R R + H ++ DS RDSP
Sbjct: 364 LSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSP 419
Query: 582 HSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPL 641
HSERYVSA+TTPAR+SPVDFH + + P E++ P S+ VS+P A +S + E++PL
Sbjct: 420 HSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMA-VSPFMEEERPL 478
Query: 642 LRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRI 701
L P P + + S+++ A SLPASP RI
Sbjct: 479 LLVTPPRLREKKFDHHP-------QQFSSFHHNPAHDS------------NSLPASPLRI 519
Query: 702 PEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSS 761
ED+EYETTQE P P + A RR +R++ NG A R L + S
Sbjct: 520 VEDEEYETTQEYEPAQEPVKKL--------ANSRRAKRTKPNGHIANR-------LEVDS 564
Query: 762 GSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT 814
+ S+++ + D+ G E TPFLG++ A ++ P ADSRT
Sbjct: 565 NTSSQSSNSESETEDERVG----EDTPFLGIQNPL-AASLEATPAFRLADSRT 612
>gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]
Length = 459
Score = 285 bits (728), Expect = 2e-76
Identities = 171/422 (40%), Positives = 241/422 (57%), Gaps = 64/422 (15%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
+ N+ S+T +S +G H KC E K+
Sbjct: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
Query: 352 YCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNFSKAEELYQKRVLTITGICV 408
+CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +F KAEELYQKRVLTITGIC+
Sbjct: 189 FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICI 248
Query: 409 ALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQMAD- 466
ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP PE +Q+ +
Sbjct: 249 ALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQ 308
Query: 467 YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSD 526
Y+SKNV +++H++ RE ET+FS SH S +HH +T T T SH+WS +ES+ S+
Sbjct: 309 YVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNGHTESILSE 363
Query: 527 SQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDSLRDSPHSE 584
S S I++SSV S+ +SP R R + H ++ DS RDSPHSE
Sbjct: 364 SHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSE 419
Query: 585 RY 586
R+
Sbjct: 420 RH 421
>gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]
Length = 420
Score = 284 bits (726), Expect = 3e-76
Identities = 171/421 (40%), Positives = 240/421 (57%), Gaps = 64/421 (15%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
+ N+ S+T +S +G H KC E K+
Sbjct: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
Query: 352 YCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNFSKAEELYQKRVLTITGICV 408
+CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +F KAEELYQKRVLTITGIC+
Sbjct: 189 FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICI 248
Query: 409 ALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQMAD- 466
ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP PE +Q+ +
Sbjct: 249 ALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQ 308
Query: 467 YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSD 526
Y+SKNV +++H++ RE ET+FS SH S +HH +T T T SH+WS +ES+ S+
Sbjct: 309 YVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNGHTESILSE 363
Query: 527 SQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDSLRDSPHSE 584
S S I++SSV S+ +SP R R + H ++ DS RDSPHSE
Sbjct: 364 SHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSE 419
Query: 585 R 585
R
Sbjct: 420 R 420
>gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]
Length = 462
Score = 270 bits (691), Expect = 3e-72
Identities = 168/425 (39%), Positives = 238/425 (56%), Gaps = 67/425 (15%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
+ N+ S+T +S +G H KC E K+
Sbjct: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
Query: 352 YCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQ---FAMVNFSKAEELYQKRVLTITG 405
+CVNGG C+ ++ ++ S CKC G+TG RC + + N KAEELYQKRVLTITG
Sbjct: 189 FCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITG 248
Query: 406 ICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQM 464
IC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP PE +Q+
Sbjct: 249 ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQL 308
Query: 465 AD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESL 523
+ Y+SKNV +++H++ RE ET+FS SH S +HH +T T T SH+WS +ES+
Sbjct: 309 VNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNGHTESI 363
Query: 524 TSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDSLRDSP 581
S+S S I++SSV S+ +SP R R + H ++ DS RDSP
Sbjct: 364 LSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSP 419
Query: 582 HSERY 586
HSER+
Sbjct: 420 HSERH 424
>gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]
Length = 308
Score = 221 bits (563), Expect = 2e-57
Identities = 122/267 (45%), Positives = 171/267 (64%), Gaps = 19/267 (7%)
Query: 330 SVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQ--- 383
+ ++T ++ + H KC E K++CVNGG C+ ++ ++ S CKC G+TG RC +
Sbjct: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
Query: 384 FAMVNFSKAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAH 443
+ N KAEELYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++
Sbjct: 73 MKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER 132
Query: 444 QN-RSLANGPSHPRLDPEEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCST 501
N ++ANGP HP PE +Q+ + Y+SKNV +++H++ RE ET+FS SH S +HH +T
Sbjct: 133 NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 192
Query: 502 ATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEE 561
T T SH+WS +ES+ S+S S I++SSV S+ +SP R
Sbjct: 193 VTQT-----PSHSWSNGHTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGG 243
Query: 562 RRRATAPPYH--DSVDSLRDSPHSERY 586
R + H ++ DS RDSPHSER+
Sbjct: 244 PRECNSFLRHARETPDSYRDSPHSERH 270
>gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens]
Length = 422
Score = 196 bits (498), Expect = 8e-50
Identities = 141/418 (33%), Positives = 208/418 (49%), Gaps = 92/418 (22%)
Query: 48 RSSSNNSSISRPAAPPEPRPQQQPQPRSPAARR--AAARSRAAAAGGMRRDPAPGFSMLL 105
RS RP + P P P P AA + AAAG + AP
Sbjct: 9 RSGRPGPRAQRPGSAARSSP---PLPLLPLLLLLGTAALAPGAAAGN---EAAPA----- 57
Query: 106 FGVSLACYS--PSLKSVQDQAYKAPVVVEGKV------QGLVPAGGSSS-------NSTR 150
G S+ CYS PS+ SVQ+ A +A VV+EGKV QG + +++ R
Sbjct: 58 -GASV-CYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDR 115
Query: 151 EPPASGRVAL------------------------------------VKVLDKWPLRSGGL 174
EPPA+G AL VKV W +++GGL
Sbjct: 116 EPPAAGPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGL 175
Query: 175 QREQVISVG----------SCVPLERNQRYIFFLEP-----TEQPLVFKTAFAPLDTNGK 219
+++ +++V SC L+ + RYIFF+EP + P F+ +F PL+T G+
Sbjct: 176 KKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLET-GR 234
Query: 220 NLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNR 279
NLKKEV ++LC CA P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR
Sbjct: 235 NLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNR 294
Query: 280 S---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLS 336
++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ + + + T +
Sbjct: 295 KNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATST 352
Query: 337 SWSG--HARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNF 389
S +G H KC E K++CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +F
Sbjct: 353 STTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF 410
>gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens]
Length = 207
Score = 122 bits (306), Expect = 1e-27
Identities = 69/187 (36%), Positives = 105/187 (56%), Gaps = 17/187 (9%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 VNSVSTTLSSWSG--HARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQ 382
+ + T +S +G H KC E K++CVNGG C+ ++ ++ S CKCP +TGDRCQ
Sbjct: 129 IVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQ 188
Query: 383 QFAMVNF 389
+ M +F
Sbjct: 189 NYVMASF 195
>gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens]
Length = 241
Score = 110 bits (275), Expect = 5e-24
Identities = 71/221 (32%), Positives = 108/221 (48%), Gaps = 51/221 (23%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
+ N+ S+T +S +G H KC E K+
Sbjct: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
Query: 352 YCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNF 389
+CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +F
Sbjct: 189 FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF 229
>gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens]
Length = 177
Score = 97.4 bits (241), Expect = 5e-20
Identities = 57/164 (34%), Positives = 90/164 (54%), Gaps = 14/164 (8%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 VNSVSTTLSSWSG--HARKCNETAKSYCVNGGVCYYIEGINQLS 369
+ + T +S +G H KC E K++CVNGG C+ ++ ++ S
Sbjct: 129 IVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPS 172
>gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens]
Length = 194
Score = 95.5 bits (236), Expect = 2e-19
Identities = 58/181 (32%), Positives = 93/181 (51%), Gaps = 31/181 (17%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRL- 326
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 327 ------------------YVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQL 368
YV+S ++T ++ + H KC E K++CVNGG C+ ++ ++
Sbjct: 129 IVESNEIITGMPASTEGAYVSSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNP 188
Query: 369 S 369
S
Sbjct: 189 S 189
>gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens]
Length = 211
Score = 85.5 bits (210), Expect = 2e-16
Identities = 59/198 (29%), Positives = 93/198 (46%), Gaps = 48/198 (24%)
Query: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
Query: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
Query: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
+ N+ S+T +S +G H KC E K+
Sbjct: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
Query: 352 YCVNGGVCYYIEGINQLS 369
+CVNGG C+ ++ ++ S
Sbjct: 189 FCVNGGECFMVKDLSNPS 206
>gi|66730481 neuregulin 3 [Homo sapiens]
Length = 696
Score = 77.8 bits (190), Expect = 4e-14
Identities = 39/114 (34%), Positives = 62/114 (54%), Gaps = 16/114 (14%)
Query: 339 SGHARKCNETAKSYCVNGGVCYYIEGI--NQLSCKCPVGYTGDRCQQFAM---------- 386
S H + C + +YC+N G C+ IE + + C+C GY G RC QF
Sbjct: 284 SEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPT 343
Query: 387 ----VNFSKAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLR 436
+ F ++EE+YQ++VL+I+ I +++VG+ C Y K+KKQ KQ+ L+
Sbjct: 344 DHLGIEFMESEEVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLK 397
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 65.1 bits (157), Expect = 3e-10
Identities = 40/68 (58%), Positives = 45/68 (66%), Gaps = 1/68 (1%)
Query: 10 PPPPLEKGRCSSYSDSSSSSSERSSSSSS-SSSESGSSSRSSSNNSSISRPAAPPEPRPQ 68
P P K R SS S SSSSSS SSSSSS SSS S SSS SSS++SS S +P +P PQ
Sbjct: 2598 PTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQ 2657
Query: 69 QQPQPRSP 76
P+P SP
Sbjct: 2658 ALPKPASP 2665
Score = 53.1 bits (126), Expect = 1e-06
Identities = 50/159 (31%), Positives = 70/159 (44%), Gaps = 22/159 (13%)
Query: 13 PLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRP------AAPPEPR 66
P ++ R SS S SSSSSS SSSSSSSSS SGSSS S +S +P P P
Sbjct: 2526 PAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPA 2585
Query: 67 PQQ-----QPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSVQ 121
P++ +P +PA R+ + S ++++ + S S + S S S
Sbjct: 2586 PKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSS---SSSSSSSSSSSSSSS 2642
Query: 122 DQAYKAPVVVEGKVQGL--------VPAGGSSSNSTREP 152
+ +P + Q L P G S S R+P
Sbjct: 2643 SSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKP 2681
Score = 52.8 bits (125), Expect = 1e-06
Identities = 41/87 (47%), Positives = 51/87 (58%), Gaps = 7/87 (8%)
Query: 20 SSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQP-----R 74
SS S SSSSSS SSSSSSSSS S SSS SSS + + P A P+P ++P P R
Sbjct: 2617 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSR 2676
Query: 75 SPAARRAAAR-SRAAAAGGM-RRDPAP 99
SP + R SR+ + + RR P+P
Sbjct: 2677 SPRKPIDSLRDSRSLSYSPVERRRPSP 2703
Score = 42.4 bits (98), Expect = 0.002
Identities = 82/359 (22%), Positives = 127/359 (35%), Gaps = 47/359 (13%)
Query: 522 SLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRD-- 579
SLTS ++ LS + P R + L +R R+ PP S +
Sbjct: 2365 SLTS-ARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSER 2423
Query: 580 --SPHS---ERYVSALTTPAR---LSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPI 631
SP S + +L PA+ SPV +S ++ + T + ++S A
Sbjct: 2424 APSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATT 2483
Query: 632 SYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSL 691
+ + +L PAP P G P Q S + PA RR + + S
Sbjct: 2484 TSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAK---ERRSSSSSSSSS 2540
Query: 692 GSLPASPFR------------------IPEDDEYETTQECAPPP----------PPRPRA 723
S +S +P E + +P P PP P
Sbjct: 2541 SSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTP 2600
Query: 724 RGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALA 783
RR+S+ S + ++ + ++ S S SS S S+S+S A AL
Sbjct: 2601 AKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALP 2660
Query: 784 AESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPPRAKQDSA 842
++P G + RS P+ DSR+ S+S R S P PR +Q S+
Sbjct: 2661 KPASPKKPPPGERRS-RSPRKPIDSLRDSRSL----SYSPVERRRPSPQPSPRDQQSSS 2714
Score = 42.0 bits (97), Expect = 0.002
Identities = 34/100 (34%), Positives = 40/100 (40%), Gaps = 8/100 (8%)
Query: 11 PPPLEKGRCSSYSDSSSSSSERSS--------SSSSSSSESGSSSRSSSNNSSISRPAAP 62
P K R S S S+SSS E S S S SS E SRSS S S P
Sbjct: 1695 PELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTK 1754
Query: 63 PEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFS 102
R + P P+ +R+ +RSR RR G S
Sbjct: 1755 TTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSS 1794
Score = 42.0 bits (97), Expect = 0.002
Identities = 43/153 (28%), Positives = 59/153 (38%)
Query: 10 PPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQ 69
PP + S+ + + RSSSSSSSSS S SSS SSS++SS S ++
Sbjct: 2509 PPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSL 2568
Query: 70 QPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSVQDQAYKAPV 129
QP R + A R P P + S + S S S + +
Sbjct: 2569 PVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSS 2628
Query: 130 VVEGKVQGLVPAGGSSSNSTREPPASGRVALVK 162
+ SSS+S+ P G AL K
Sbjct: 2629 SSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPK 2661
Score = 40.4 bits (93), Expect = 0.007
Identities = 47/187 (25%), Positives = 65/187 (34%), Gaps = 41/187 (21%)
Query: 8 ALPPPPLEKGRCSSYSDSSSS----SSERSSSSSSSSSES------GSSSRSSSNNSSIS 57
ALP P + R S + ++ ERS S SS ++ G SRS S+
Sbjct: 1488 ALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDV 1547
Query: 58 RPAAPPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSL 117
+P+A P+ R + P S A R R R+ + D S S S
Sbjct: 1548 KPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLS------PRRSRSGSS 1601
Query: 118 KSVQDQAYKAPVVVEG-------------------------KVQGLVPAGGSSSNSTREP 152
V+D+ AP G K +G P G SS+ S+ E
Sbjct: 1602 PEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEH 1661
Query: 153 PASGRVA 159
P R A
Sbjct: 1662 PPKSRTA 1668
Score = 35.0 bits (79), Expect = 0.29
Identities = 26/90 (28%), Positives = 37/90 (41%), Gaps = 1/90 (1%)
Query: 11 PPPLEKGRCSSYSDSSSSSSERSSSSS-SSSSESGSSSRSSSNNSSISRPAAPPEPRPQQ 69
P P K R SS SS E + + S S S SSS + + + +P P+
Sbjct: 1676 PEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEP 1735
Query: 70 QPQPRSPAARRAAARSRAAAAGGMRRDPAP 99
+ RS RR+A+ R R P+P
Sbjct: 1736 AEKSRSSRRRRSASSPRTKTTSRRGRSPSP 1765
Score = 34.7 bits (78), Expect = 0.38
Identities = 25/72 (34%), Positives = 27/72 (37%), Gaps = 5/72 (6%)
Query: 10 PPPPLEKGRCSSYSD-----SSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPE 64
P L R SYS S S R SSSS S R S + S R P
Sbjct: 2681 PIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPS 2740
Query: 65 PRPQQQPQPRSP 76
PRP + RSP
Sbjct: 2741 PRPMRHRSSRSP 2752
Score = 33.9 bits (76), Expect = 0.65
Identities = 24/86 (27%), Positives = 37/86 (43%), Gaps = 9/86 (10%)
Query: 23 SDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPRSPAAR--- 79
S S SSS R S SSS S + ++ + PEP+ + + PR ++R
Sbjct: 1636 SRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSP 1695
Query: 80 ------RAAARSRAAAAGGMRRDPAP 99
R + RSR+A++ R P
Sbjct: 1696 ELTRKARLSRRSRSASSSPETRSRTP 1721
Score = 33.1 bits (74), Expect = 1.1
Identities = 26/89 (29%), Positives = 37/89 (41%), Gaps = 2/89 (2%)
Query: 13 PLEKGRCSSYSDSSSSSSERSSSSSSSSSESGS--SSRSSSNNSSISRPAAPPEPRPQQQ 70
P +GR S + + S RS S S S + S RS S + + P + +
Sbjct: 609 PARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGR 668
Query: 71 PQPRSPAARRAAARSRAAAAGGMRRDPAP 99
+ R+PA R +RSR A G R P
Sbjct: 669 SRSRTPARRSGRSRSRTPARRGRSRSRTP 697
Score = 33.1 bits (74), Expect = 1.1
Identities = 27/83 (32%), Positives = 38/83 (45%), Gaps = 8/83 (9%)
Query: 25 SSSSSSERSSSSSSSSSESGSSSRS------SSNNSSISRPAAPPEPRPQ-QQPQPRSPA 77
+S SSS+RS S++ ++ + S SR+ SS S SRP+ P P + + P P
Sbjct: 2080 ASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPL 2139
Query: 78 ARRAAARSRAAAAGGMRRD-PAP 99
S AGG D P P
Sbjct: 2140 GSSRTPMSVLQQAGGSMMDGPGP 2162
Score = 32.7 bits (73), Expect = 1.4
Identities = 22/79 (27%), Positives = 32/79 (40%), Gaps = 8/79 (10%)
Query: 24 DSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQ--------PQPRS 75
D S+ S SSS S S+N SIS P PR + P+ +
Sbjct: 1370 DMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKD 1429
Query: 76 PAARRAAARSRAAAAGGMR 94
R + RSR+ ++ G+R
Sbjct: 1430 GLPRTPSRRSRSGSSPGLR 1448
Score = 32.3 bits (72), Expect = 1.9
Identities = 81/378 (21%), Positives = 122/378 (32%), Gaps = 85/378 (22%)
Query: 470 KNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESH--------TWSLERSE 521
K++P T R E ++ SP TP R S T ERS
Sbjct: 1467 KDIPRTPSRGRSECDS--------SPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSG 1518
Query: 522 SLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSP 581
S +S Q + + +G R+R ++ L+ + A+ P DS DS
Sbjct: 1519 SESSVDQKTVARTPLGQ-----------RSRSGSSQELDVKPSAS-PQERSESDSSPDSK 1566
Query: 582 HSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPL 641
R + + SP +V + SP + + S P + +P
Sbjct: 1567 AKTRTPLRQRSRSGSSP---------EVDSKSRLSPRRSRSGSSPEV--------KDKPR 1609
Query: 642 LRHPAPPGPGPGPGP-GPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFR 700
A G P P P P A +RS GP P + S +SP
Sbjct: 1610 AAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSS--------STESSPEH 1661
Query: 701 IPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLS 760
P+ +P P + R R + + P R++RL ++R+R+A S
Sbjct: 1662 PPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARL----SRRSRSASSSPETR 1717
Query: 761 SGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDS 820
S TP R S P + SR S S
Sbjct: 1718 S------------------------RTP---PRHRRSPSVSSPEPAEKSRSSRRRRSASS 1750
Query: 821 HSTRASSRHSRGPPPRAK 838
T+ +SR R P P+ +
Sbjct: 1751 PRTKTTSRRGRSPSPKPR 1768
Score = 31.6 bits (70), Expect = 3.2
Identities = 20/77 (25%), Positives = 34/77 (44%)
Query: 18 RCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPRSPA 77
R + +SS +SS R S + S SRS ++ + R + P ++ + R+P
Sbjct: 1823 RSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPL 1882
Query: 78 ARRAAARSRAAAAGGMR 94
R +RSR + R
Sbjct: 1883 ISRRRSRSRTSPVSRRR 1899
Score = 31.6 bits (70), Expect = 3.2
Identities = 26/79 (32%), Positives = 36/79 (45%), Gaps = 10/79 (12%)
Query: 18 RCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPR----------P 67
R S S +S + RS S +S + S SR+S SR PP R P
Sbjct: 1979 RRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLP 2038
Query: 68 QQQPQPRSPAARRAAARSR 86
+++ + RSP A R +RSR
Sbjct: 2039 RKRSRSRSPLAIRRRSRSR 2057
Score = 31.6 bits (70), Expect = 3.2
Identities = 35/126 (27%), Positives = 47/126 (37%), Gaps = 21/126 (16%)
Query: 32 RSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPRSPAARRAAARSRAAAAG 91
RS + S+ S+S +S + + SS A P Q QPRSP + +SR A
Sbjct: 2406 RSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIA- 2464
Query: 92 GMRRDPAPGFSMLLFGVSLACYSPSLKSVQDQAYKAPVVVEGKVQGL--VPAGGSSSNST 149
+ P G L G S + G G+ VPA G +
Sbjct: 2465 --QTTPVAGSQSLSSGAVATTTSSA----------------GDHNGMLSVPAPGVPHSDV 2506
Query: 150 REPPAS 155
EPPAS
Sbjct: 2507 GEPPAS 2512
Score = 31.2 bits (69), Expect = 4.2
Identities = 25/84 (29%), Positives = 35/84 (41%), Gaps = 7/84 (8%)
Query: 2 RQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAA 61
R+ C + P P L+ S +S S SS SS+ S S SSS + IS
Sbjct: 869 RRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIIS---- 924
Query: 62 PPEPRPQQQPQPRSPAARRAAARS 85
PR + SP+ R +R+
Sbjct: 925 ---PRQRSHSGSSSPSPSRVTSRT 945
Score = 30.8 bits (68), Expect = 5.5
Identities = 39/160 (24%), Positives = 66/160 (41%), Gaps = 10/160 (6%)
Query: 1 MRQVCCSALPPPPLEKGRCSS----YSDSSSSSSERSSSSSS--SSSESGSSSRSSSNNS 54
+R+ S P P +K + S+SSS ER SS SES S R + +
Sbjct: 174 VRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPT 233
Query: 55 SISRPAAPPEPRPQQQPQPRSPAARRA--AARSRAAAAGGMRRDPAPGFSMLLFGVSLAC 112
S+ + + R + + +P +RRA + + +A++ R + + +LA
Sbjct: 234 PKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAG 293
Query: 113 YSPSLKSVQDQAYKAPVVVEGKVQGLVPAGGSSSNSTREP 152
SPS S + AP G P+ S +T++P
Sbjct: 294 RSPSPASGRRGEGDAPFSEPGTTSTQRPS--SPETATKQP 331
Score = 30.8 bits (68), Expect = 5.5
Identities = 94/440 (21%), Positives = 145/440 (32%), Gaps = 71/440 (16%)
Query: 423 KTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRRE 482
K KK R + + R++ P P R ++ + + P + R
Sbjct: 214 KKKKHRSESESKKRKHRSPT---------PKSKRKSKDKKRKRSRSTTPAPKSRRA-HRS 263
Query: 483 TETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLE-RSESLTSD--SQSGIMLSSVGTS 539
T + S S S S A T HT +L RS S S + S GT+
Sbjct: 264 TSADSASSSDTSRSRSRSAAAKT-------HTTALAGRSPSPASGRRGEGDAPFSEPGTT 316
Query: 540 KCNSPACVEARARRAAA-YNLEER----RRATAPPYHDSVDSLRDSPHS------ERYVS 588
P+ E ++ ++ Y +++ + AT P S P + ER+
Sbjct: 317 STQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGG 376
Query: 589 A----LTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRH 644
+ TTP PV+ + PT + + P S + ++ S + + RH
Sbjct: 377 SPQPLATTPLSQEPVN---PPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRH 433
Query: 645 PAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPF---RI 701
+ P P P PG ++ S S G S P+ R
Sbjct: 434 ASSSPESPKPAPAPGSHREISSSPTS-------KNRSHGRAKRDKSHSHTPSRRMGRSRS 486
Query: 702 PEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARD------ 755
P + ++ P R+R R S +RW RSR + QR +R
Sbjct: 487 PATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSR----SPQRRGRSRSPQRPGW 542
Query: 756 SLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTY 815
S S ++ G S SA + A S RS +P + SRT
Sbjct: 543 SRSRNTQRRGRSRSARRGRSHSRSPATRGRS-------------RSRTPARRGRSRSRTP 589
Query: 816 YSLDSHSTRASSRHSRGPPP 835
S S + R SR P
Sbjct: 590 ARRRSRSRTPTRRRSRSRTP 609
Score = 30.4 bits (67), Expect = 7.2
Identities = 26/88 (29%), Positives = 43/88 (48%), Gaps = 3/88 (3%)
Query: 13 PLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRP-QQQP 71
P +GR S + + S RS + + S S + +R S + + +R P +++
Sbjct: 567 PATRGRSRSRTPARRGRS-RSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRS 625
Query: 72 QPRSPAARRAAARSRAAAAGGMR-RDPA 98
+ RSP RR+ +RS A +G R R PA
Sbjct: 626 RTRSPVRRRSRSRSPARRSGRSRSRTPA 653
>gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]
Length = 296
Score = 60.8 bits (146), Expect = 5e-09
Identities = 25/61 (40%), Positives = 40/61 (65%), Gaps = 3/61 (4%)
Query: 332 STTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVN 388
++T ++ + H KC E K++CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +
Sbjct: 224 TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMAS 283
Query: 389 F 389
F
Sbjct: 284 F 284
>gi|93102361 palladin [Homo sapiens]
Length = 1106
Score = 60.5 bits (145), Expect = 6e-09
Identities = 33/96 (34%), Positives = 51/96 (53%), Gaps = 2/96 (2%)
Query: 239 LKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQF 298
++K++SQ G + L+C GNP P RWF +GKEL+ + DI+I G ++ L
Sbjct: 274 IQKLRSQEVAEGSRVYLECRVT-GNPTPRVRWFCEGKELHNTPDIQIHCEGGDLHT-LII 331
Query: 299 NKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTT 334
+ +D G Y C A N G DT +++ S+T
Sbjct: 332 AEAFEDDTGRYTCLATNPSGSDTTSAEVFIEGASST 367
Score = 43.9 bits (102), Expect = 6e-04
Identities = 31/114 (27%), Positives = 47/114 (41%), Gaps = 7/114 (6%)
Query: 240 KKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSR---- 295
K++++ G+ L+C G P +WF+ G E+ S D RI R +
Sbjct: 445 KELQNTAVAEGQVVVLECRVR-GAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAEPEEI 503
Query: 296 --LQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNE 347
L + EDAG + C A N G T +L V S +T S+ N+
Sbjct: 504 CTLVIAETFPEDAGIFTCSARNDYGSATSTAQLVVTSANTENCSYESMGESNND 557
Score = 43.5 bits (101), Expect = 8e-04
Identities = 24/72 (33%), Positives = 35/72 (48%)
Query: 261 AGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKD 320
AGNP+P WFKDGK+++ D + L ++D G Y A N G+
Sbjct: 801 AGNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANPQGRI 860
Query: 321 TVRGRLYVNSVS 332
+ GRL V +V+
Sbjct: 861 SCTGRLMVQAVN 872
>gi|10864029 junctional adhesion molecule 2 precursor [Homo sapiens]
Length = 298
Score = 58.2 bits (139), Expect = 3e-08
Identities = 31/74 (41%), Positives = 35/74 (47%), Gaps = 5/74 (6%)
Query: 250 GEKQSLKCEAAAGNPQPSYRWFKDGKELNR-----SRDIRIKYGNGRKNSRLQFNKVKVE 304
G L+C+ GNP P Y WFKDG L S+ Y K LQFN V
Sbjct: 148 GTVVELRCQDKEGNPAPEYTWFKDGIRLLENPRLGSQSTNSSYTMNTKTGTLQFNTVSKL 207
Query: 305 DAGEYVCEAENILG 318
D GEY CEA N +G
Sbjct: 208 DTGEYSCEARNSVG 221
>gi|153792294 myopalladin [Homo sapiens]
Length = 1320
Score = 58.2 bits (139), Expect = 3e-08
Identities = 35/111 (31%), Positives = 51/111 (45%), Gaps = 3/111 (2%)
Query: 240 KKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFN 299
+K++S+ G + L C G P P RW+ +GKEL S DI I + L
Sbjct: 273 QKLRSREVPEGTRVQLDC-IVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHS--LTIA 329
Query: 300 KVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAK 350
+ ED G Y C A NI G D+ +Y+ VS++ S + + N K
Sbjct: 330 EAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQK 380
Score = 40.4 bits (93), Expect = 0.007
Identities = 32/145 (22%), Positives = 57/145 (39%), Gaps = 3/145 (2%)
Query: 187 PLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLKKMKSQT 246
P ++ + F + + F+ P+D + ++ + +I C K++K
Sbjct: 898 PNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHD--EIPTGKCIAPIFDKRLKHFR 955
Query: 247 GQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDA 306
G + C+ G P P WFKDGK++++ + G L +D
Sbjct: 956 VTEGSPVTFTCKIV-GIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD 1014
Query: 307 GEYVCEAENILGKDTVRGRLYVNSV 331
G Y A N G+ + G L V S+
Sbjct: 1015 GNYTIMAANPQGRISCSGHLMVQSL 1039
Score = 36.2 bits (82), Expect = 0.13
Identities = 26/109 (23%), Positives = 46/109 (42%), Gaps = 7/109 (6%)
Query: 240 KKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSR---- 295
K +++ + G+ +C G P P W+++G + S D RI R +
Sbjct: 439 KMLQNLSASEGQLVVFECRVK-GAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEI 497
Query: 296 --LQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHA 342
L +V ED+G + C A N G + +L+V ++ S H+
Sbjct: 498 CTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHS 546
>gi|153792780 additional sex combs like 2 [Homo sapiens]
Length = 1435
Score = 56.6 bits (135), Expect = 9e-08
Identities = 86/372 (23%), Positives = 136/372 (36%), Gaps = 59/372 (15%)
Query: 412 VVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAH-QNRSLANGPSHPRLDP--EEIQMADYI 468
++ IV VV+ + K++ QM + R+ C + + + + S P L +++ +
Sbjct: 419 LIRIVPVVSQSECKEEALQMSSPGRKEECESQGEVQPNFSTSSEPLLSSALNTHELSSIL 478
Query: 469 SKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSES------ 522
P + ++ ++ T S +H + + S ES S + +S
Sbjct: 479 PIKCPKDEDLLEQKPVT--SAEQESEKNHLTTASNYNKSESQESLVTSPSKPKSPGVEKP 536
Query: 523 -----LTSDSQSGIMLSSVGTSKCNSPACVEARA---RRAAAYNLEERRRATAPPYHDSV 574
+ Q M + T SP ++ ++ + A + E+R R T H
Sbjct: 537 IVKPTAGAGPQETNMKEPLATLVDQSPESLKRKSSLTQEEAPVSWEKRPRVTENRQHQQP 596
Query: 575 DSLRDSPHSER-------YVSALTTP-ARLSPVDFHYSLATQVPTF--EITSPNSAHAVS 624
+ P R V L P +R+SP+ FH S + F ITSPN A +
Sbjct: 597 FQVSPQPFLNRGDRIQVRKVPPLKIPVSRISPMPFHPSQVSPRARFPVSITSPNRTGART 656
Query: 625 LPPAAPISYRLAEQQPLLRHPAP-----------PGPGPGPGPGPGPGADMQR----SYD 669
L + + Q+ A PGPGPG G GPG G + Q S
Sbjct: 657 LADIKAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGEGQTARGGSPG 716
Query: 670 SYYYPAAGPGPR---RGTCALGGSLGSLPASPFRIPEDDEYETTQEC------------A 714
S G GP GT + GG+ LP P P+ + T +
Sbjct: 717 SDRVSETGKGPTLELAGTGSRGGTRELLPCGPETQPQSETKTTPSQAQPHSVSGAQLQQT 776
Query: 715 PPPPPRPRARGA 726
PP PP P GA
Sbjct: 777 PPVPPTPAVSGA 788
Score = 35.8 bits (81), Expect = 0.17
Identities = 36/149 (24%), Positives = 56/149 (37%), Gaps = 16/149 (10%)
Query: 9 LPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQ 68
+PP P G C+S + +E + +R+++ +S+S P P R +
Sbjct: 779 VPPTPAVSGACTSVPSPAHIEK--------LDNEKLNPTRATATVASVSHPQGPSSCRQE 830
Query: 69 QQPQPRSPAARRAAARSRAAA-------AGGMRRDPAPGFSMLLFGVSLACYSPS-LKSV 120
+ P P PA A+ AA AG + P P S +PS L S+
Sbjct: 831 KAPSPTGPALISGASPVHCAADGTVELKAGPSKNIPNPSASSKTDASVPVAVTPSPLTSL 890
Query: 121 QDQAYKAPVVVEGKVQGLVPAGGSSSNST 149
A + V PAG + +ST
Sbjct: 891 LTTATLEKLPVPQVSATTAPAGSAPPSST 919
Score = 30.4 bits (67), Expect = 7.2
Identities = 21/47 (44%), Positives = 24/47 (51%), Gaps = 1/47 (2%)
Query: 20 SSYSDSSSSSSERSSSSS-SSSSESGSSSRSSSNNSSISRPAAPPEP 65
SS S S SSE SSSSS S++ G SR SS S + P P
Sbjct: 101 SSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKRKVSSSSPQSGCPSP 147
>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
Length = 2968
Score = 55.8 bits (133), Expect = 2e-07
Identities = 46/132 (34%), Positives = 59/132 (44%), Gaps = 14/132 (10%)
Query: 20 SSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPRSPAAR 79
SS S SSSSSS SSSSSSSSS S SSS SSS++SS + + + P P + +
Sbjct: 2636 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGPSA 2695
Query: 80 RAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSVQDQAYKAPVVVEGKVQGLV 139
+AA ++A G R A +SP K+ Q P +Q
Sbjct: 2696 QAALPTKATKQAGKARPSA--------------HSPGKKTPAPQPQAPPPQPTQPLQPKA 2741
Query: 140 PAGGSSSNSTRE 151
AG S RE
Sbjct: 2742 QAGAKSRPKKRE 2753
Score = 40.8 bits (94), Expect = 0.005
Identities = 26/73 (35%), Positives = 41/73 (56%)
Query: 17 GRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPRSP 76
GR S + S ++S SSSSSSSSS S SSS SSS++SS S ++ S
Sbjct: 2599 GRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2658
Query: 77 AARRAAARSRAAA 89
++ +++ S +++
Sbjct: 2659 SSSSSSSSSSSSS 2671
Score = 38.9 bits (89), Expect = 0.020
Identities = 22/74 (29%), Positives = 42/74 (56%)
Query: 17 GRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPRSP 76
G C + + S++S R++S +SSSS S SSS SSS++SS S ++ S
Sbjct: 2593 GGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2652
Query: 77 AARRAAARSRAAAA 90
++ +++ S ++++
Sbjct: 2653 SSSSSSSSSSSSSS 2666
Score = 35.4 bits (80), Expect = 0.22
Identities = 27/83 (32%), Positives = 39/83 (46%), Gaps = 15/83 (18%)
Query: 23 SDSSSSSSERSSSSSSSSSESGSSSRSSS---------------NNSSISRPAAPPEPRP 67
S+SSSSSS SSSSSSSSS SGS + N S+ S AA P
Sbjct: 2557 SESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSS 2616
Query: 68 QQQPQPRSPAARRAAARSRAAAA 90
S ++ +++ S ++++
Sbjct: 2617 SSSSSSSSSSSSSSSSSSSSSSS 2639
Score = 34.7 bits (78), Expect = 0.38
Identities = 56/249 (22%), Positives = 84/249 (33%), Gaps = 19/249 (7%)
Query: 607 TQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQR 666
T P E + A A SL PA I+ +P A GP PG A++
Sbjct: 2404 TSCPAPEPFAELPAPATSLAPAPLITMPATRPKPKKARAAEESGAKGPRR-PGEEAELLV 2462
Query: 667 SYDSYYYPAAGPGPRRGTCAL------GGSLGSLPASPFRIPEDDEYETTQECAPPPPPR 720
D + P ++ AL G P S + Y + P P
Sbjct: 2463 KLD--HEGVTSPKSKKAKEALLLREDPGAGGWQEPKSLLSL---GSYPPAAGSSEPKAPW 2517
Query: 721 PRARGASRRTSAGPRRWRRSRLNGLAAQRARAARD------SLSLSSGSGGGSASASDDD 774
P+A GP N + +A+A +D S S SS S+S+S
Sbjct: 2518 PKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSS 2577
Query: 775 ADDADGALAAESTPFLGL-RGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGP 833
+ +G + G G + + S PA+ S + S S S+ +SS S
Sbjct: 2578 GSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSS 2637
Query: 834 PPRAKQDSA 842
+ S+
Sbjct: 2638 SSSSSSSSS 2646
Score = 34.7 bits (78), Expect = 0.38
Identities = 38/142 (26%), Positives = 54/142 (38%), Gaps = 1/142 (0%)
Query: 15 EKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPR 74
+ G S + + S SSSSS SGSSS SSS++SS S E
Sbjct: 2537 DSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCG 2596
Query: 75 SPAARRAAARSRAAA-AGGMRRDPAPGFSMLLFGVSLACYSPSLKSVQDQAYKAPVVVEG 133
+ +AA SRAA+ A + S S + S S S + +
Sbjct: 2597 TGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2656
Query: 134 KVQGLVPAGGSSSNSTREPPAS 155
+ SSS+ST + +S
Sbjct: 2657 SSSSSSSSSSSSSSSTTDEDSS 2678
Score = 31.2 bits (69), Expect = 4.2
Identities = 17/39 (43%), Positives = 20/39 (51%)
Query: 13 PLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSS 51
P + + D + S SSSSS SSS S SSS S S
Sbjct: 2541 PKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGS 2579
Score = 30.4 bits (67), Expect = 7.2
Identities = 18/41 (43%), Positives = 21/41 (51%)
Query: 11 PPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSS 51
P +K + S SS SSS SSSSS S SSS S +
Sbjct: 2541 PKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSET 2581
Score = 30.0 bits (66), Expect = 9.4
Identities = 34/114 (29%), Positives = 48/114 (42%), Gaps = 17/114 (14%)
Query: 7 SALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPR 66
+ LP GR + S++ S +S+ S SGS +R ++ RP +
Sbjct: 556 AVLPRSAATCGRPVADMHSAAHGSGEASAMQSLIKYSGSFAR----DAVAVRPGGCGKKS 611
Query: 67 P-------QQQPQPRSPAARRAAAR---SRAAAAGG---MRRDPAPGFSMLLFG 107
P + +P P S A RA AR S AAGG ++RDP S FG
Sbjct: 612 PFGGLGTMKPEPAPTSAGASRAQARLPHSGGPAAGGGRQLKRDPERPESAKAFG 665
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 55.1 bits (131), Expect = 3e-07
Identities = 29/77 (37%), Positives = 42/77 (54%), Gaps = 5/77 (6%)
Query: 242 MKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKV 301
+++QT +GE + C A+GNP P WFKD + L I +K G N L +V
Sbjct: 673 LENQTTSIGESIEVSC-TASGNPPPQIMWFKDNETLVEDSGIVLKDG----NRNLTIRRV 727
Query: 302 KVEDAGEYVCEAENILG 318
+ ED G Y C+A ++LG
Sbjct: 728 RKEDEGLYTCQACSVLG 744
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 54.3 bits (129), Expect = 5e-07
Identities = 38/110 (34%), Positives = 55/110 (50%), Gaps = 7/110 (6%)
Query: 239 LKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQF 298
++K +S G+ +L+C AG P+ S +WFKDGKEL +I + N K S L+
Sbjct: 7589 VEKPESIKVTTGDTCTLEC-TVAGTPELSTKWFKDGKELTSDNKYKISFFN--KVSGLKI 7645
Query: 299 NKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNET 348
V D+G Y E +N +GKD+ L V+ + S RK ET
Sbjct: 7646 INVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPS----FTRKLKET 7691
Score = 53.5 bits (127), Expect = 8e-07
Identities = 27/70 (38%), Positives = 42/70 (60%), Gaps = 3/70 (4%)
Query: 249 VGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGE 308
VG+ SL+C+ A G P+ + W+K +L + + R + N + L FNKV + D+GE
Sbjct: 6092 VGDSVSLQCQVA-GTPEITVSWYKGDTKLRPTPEYRTYFTNNV--ATLVFNKVNINDSGE 6148
Query: 309 YVCEAENILG 318
Y C+AEN +G
Sbjct: 6149 YTCKAENSIG 6158
Score = 53.1 bits (126), Expect = 1e-06
Identities = 29/72 (40%), Positives = 40/72 (55%), Gaps = 3/72 (4%)
Query: 250 GEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEY 309
GE L C+ G+P WFK+ KEL+ S +R+ + N + L VKVED+G Y
Sbjct: 3752 GESARLHCKLK-GSPVIQVTWFKNNKELSESNTVRMYFVNSE--AILDITDVKVEDSGSY 3808
Query: 310 VCEAENILGKDT 321
CEA N +G D+
Sbjct: 3809 SCEAVNDVGSDS 3820
Score = 52.8 bits (125), Expect = 1e-06
Identities = 26/81 (32%), Positives = 48/81 (59%), Gaps = 3/81 (3%)
Query: 239 LKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQF 298
+K+++ VG+ SL+C+ A G P+ W+K +L + ++ + N + L F
Sbjct: 7964 VKQLEPVKVSVGDSASLQCQLA-GTPEIGVSWYKGDTKLRPTTTYKMHFRNNV--ATLVF 8020
Query: 299 NKVKVEDAGEYVCEAENILGK 319
N+V + D+GEY+C+AEN +G+
Sbjct: 8021 NQVDINDSGEYICKAENSVGE 8041
Score = 51.2 bits (121), Expect = 4e-06
Identities = 30/83 (36%), Positives = 47/83 (56%), Gaps = 3/83 (3%)
Query: 239 LKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQF 298
++K T VGE +L+C+ A G P+ S W+KDGK L S+ + + N K S L+
Sbjct: 5707 VEKAGPMTVTVGETCTLECKVA-GTPELSVEWYKDGKLLTSSQKHKFSFYN--KISSLRI 5763
Query: 299 NKVKVEDAGEYVCEAENILGKDT 321
V+ +DAG Y + +N +GK +
Sbjct: 5764 LSVERQDAGTYTFQVQNNVGKSS 5786
Score = 50.4 bits (119), Expect = 7e-06
Identities = 32/100 (32%), Positives = 56/100 (56%), Gaps = 8/100 (8%)
Query: 224 EVGKILCT---DCATRPK-LKKMK-SQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELN 278
+VGK +C+ PK +KK++ S+ + GE L+C+ + G+P+ WF++ EL+
Sbjct: 6348 DVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKIS-GSPEIKVSWFRNDSELH 6406
Query: 279 RSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILG 318
S + + N + L N+ ED+G+Y+CEA N +G
Sbjct: 6407 ESWKYNMSFINSV--ALLTINEASAEDSGDYICEAHNGVG 6444
Score = 50.1 bits (118), Expect = 9e-06
Identities = 27/89 (30%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 240 KKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFN 299
KK+ +G ++C+ + P S +WFKDGKE++ S R+ ++ L+ N
Sbjct: 5241 KKLTKMDKVLGSSIHMECKVSGSLPI-SAQWFKDGKEISTSAKYRLVCHE--RSVSLEVN 5297
Query: 300 KVKVEDAGEYVCEAENILGKDTVRGRLYV 328
+++ED Y C+ N+ G D G L V
Sbjct: 5298 NLELEDTANYTCKVSNVAGDDACSGILTV 5326
Score = 50.1 bits (118), Expect = 9e-06
Identities = 29/91 (31%), Positives = 46/91 (50%), Gaps = 3/91 (3%)
Query: 240 KKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFN 299
K+MK T ++GE L C+ G P P +W++ GKEL +SR + K + + L
Sbjct: 30537 KEMKDVTTKLGEAAQLSCQIV-GRPLPDIKWYRFGKELIQSR--KYKMSSDGRTHTLTVM 30593
Query: 300 KVKVEDAGEYVCEAENILGKDTVRGRLYVNS 330
+ ED G Y C A N +G+ +L + +
Sbjct: 30594 TEEQEDEGVYTCIATNEVGEVETSSKLLLQA 30624
Score = 48.5 bits (114), Expect = 3e-05
Identities = 30/115 (26%), Positives = 49/115 (42%), Gaps = 10/115 (8%)
Query: 221 LKKEVGKILCTDCATRPKLKK-------MKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKD 273
+ + G LCT + KK + T GE L C P +W K
Sbjct: 8324 VSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPI-RIQWLKA 8382
Query: 274 GKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV 328
G+E+ S + +G + L+ V D+G+YVC+A N+ G DT + ++ +
Sbjct: 8383 GREIKPSDRCSFSFASG--TAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTI 8435
Score = 47.0 bits (110), Expect = 7e-05
Identities = 32/114 (28%), Positives = 61/114 (53%), Gaps = 8/114 (7%)
Query: 220 NLKKEVGKILCTDC--ATRPK--LKKMK-SQTGQVGEKQSLKCEAAAGNPQPSYRWFKDG 274
++ +VG CT T P +KK++ S+ + G+ L+C+ A G+P+ WF++
Sbjct: 5403 HVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECKIA-GSPEIRVVWFRNE 5461
Query: 275 KELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV 328
EL S R+ + + + +Q N + ED+G+++CEA+N G + ++ V
Sbjct: 5462 HELPASDKYRMTFIDSV--AVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIV 5513
Score = 45.8 bits (107), Expect = 2e-04
Identities = 29/89 (32%), Positives = 41/89 (46%), Gaps = 3/89 (3%)
Query: 240 KKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFN 299
K +++ V L C+ A P WFKDGKE+ S RI + G + L+
Sbjct: 4117 KPLRNVDSVVNGTCRLDCKIAGSLPM-RVSWFKDGKEIAASDRYRIAFVEG--TASLEII 4173
Query: 300 KVKVEDAGEYVCEAENILGKDTVRGRLYV 328
+V + DAG + C A N +G G L V
Sbjct: 4174 RVDMNDAGNFTCRATNSVGSKDSSGALIV 4202
Score = 45.4 bits (106), Expect = 2e-04
Identities = 25/77 (32%), Positives = 39/77 (50%), Gaps = 3/77 (3%)
Query: 244 SQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKV 303
SQ + G+ L C+ G P WF + +E+ S R+ + + L+ V +
Sbjct: 4308 SQLLKKGDATQLACKVT-GTPPIKITWFANDREIKESSKHRMSFVES--TAVLRLTDVGI 4364
Query: 304 EDAGEYVCEAENILGKD 320
ED+GEY+CEA+N G D
Sbjct: 4365 EDSGEYMCEAQNEAGSD 4381
Score = 45.1 bits (105), Expect = 3e-04
Identities = 27/87 (31%), Positives = 44/87 (50%), Gaps = 3/87 (3%)
Query: 243 KSQTGQVGEKQSLKCEAA-AGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKV 301
K+++ V EK + E AG P+ +W KDGK++ SR + + N + R+Q V
Sbjct: 5146 KAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQ--SV 5203
Query: 302 KVEDAGEYVCEAENILGKDTVRGRLYV 328
+D+G+Y + EN G + L V
Sbjct: 5204 MKQDSGQYTFKVENDFGSSSCDAYLRV 5230
Score = 45.1 bits (105), Expect = 3e-04
Identities = 32/115 (27%), Positives = 50/115 (43%), Gaps = 10/115 (8%)
Query: 221 LKKEVGKILCT------DCATRPKL-KKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKD 273
++ VGK CT D P +K+K G G ++C+ G+P S WF +
Sbjct: 7660 VQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVY-GSPPISVSWFHE 7718
Query: 274 GKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV 328
G E++ R + + L N ++ D+G+Y C A N+ G D L V
Sbjct: 7719 GNEISSGRKYQTTLTDN--TCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTV 7771
Score = 44.7 bits (104), Expect = 4e-04
Identities = 38/145 (26%), Positives = 57/145 (39%), Gaps = 15/145 (10%)
Query: 190 RNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPK------LKKMK 243
R+ +YI LE + +T E G + CT T + L + K
Sbjct: 3505 RSSKYISSLE------ILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPK 3558
Query: 244 SQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKV 303
S T VG+ C G P W KDG L+ S + RI + L+ + + +
Sbjct: 3559 SLTTFVGKAAKFIC-TVTGTPVIETIWQKDGAALSPSPNWRIS--DAENKHILELSNLTI 3615
Query: 304 EDAGEYVCEAENILGKDTVRGRLYV 328
+D G Y C+A N G D + L +
Sbjct: 3616 QDRGVYSCKASNKFGADICQAELII 3640
Score = 44.7 bits (104), Expect = 4e-04
Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 6/91 (6%)
Query: 238 KLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQ 297
KLKKM S G + L+C A +P S +WFKD +E++ S + + + + L+
Sbjct: 4680 KLKKMDSIKGSFID---LECIVAGSHPI-SIQWFKDDQEISASEKYKFSFHDN--TAFLE 4733
Query: 298 FNKVKVEDAGEYVCEAENILGKDTVRGRLYV 328
++++ D+G Y C A N G + G L V
Sbjct: 4734 ISQLEGTDSGTYTCSATNKAGHNQCSGHLTV 4764
Score = 43.9 bits (102), Expect = 6e-04
Identities = 27/91 (29%), Positives = 46/91 (50%), Gaps = 3/91 (3%)
Query: 239 LKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQF 298
++K + T G +L+C G P+ S +WFKDG+EL+ I + N K + L+
Sbjct: 6648 IEKPEPMTVTTGNPFALEC-VVTGTPELSAKWFKDGRELSADSKHHITFIN--KVASLKI 6704
Query: 299 NKVKVEDAGEYVCEAENILGKDTVRGRLYVN 329
++ D G Y E +N +GK ++V+
Sbjct: 6705 PCAEMSDKGLYSFEVKNSVGKSNCTVSVHVS 6735
Score = 43.5 bits (101), Expect = 8e-04
Identities = 23/77 (29%), Positives = 41/77 (53%), Gaps = 3/77 (3%)
Query: 242 MKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKV 301
+K+ T GE +L+C + G P P+ W+++ ++ S D +I + +G +RL +
Sbjct: 949 LKNVTVIEGESVTLECHIS-GYPSPTVTWYREDYQIESSIDFQITFQSG--IARLMIREA 1005
Query: 302 KVEDAGEYVCEAENILG 318
ED+G + C A N G
Sbjct: 1006 FAEDSGRFTCSAVNEAG 1022
Score = 43.5 bits (101), Expect = 8e-04
Identities = 32/115 (27%), Positives = 50/115 (43%), Gaps = 10/115 (8%)
Query: 221 LKKEVGKILCT------DCATRPKL-KKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKD 273
++ VGK CT D A P +++K+ G +G L+C+ A +P S WF +
Sbjct: 5778 VQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPI-SVAWFHE 5836
Query: 274 GKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV 328
++ + + + LQ N + D G Y C A N+ G D R L V
Sbjct: 5837 KTKIVSGAKYQTTFSDNV--CTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTV 5889
Score = 43.1 bits (100), Expect = 0.001
Identities = 24/68 (35%), Positives = 37/68 (54%), Gaps = 3/68 (4%)
Query: 254 SLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEA 313
SL+CE + G P W+KD ++L S+ +I N ++ + V D GEY C+A
Sbjct: 5535 SLECELS-GTPPFEVVWYKDKRQLRSSKKYKIASKNF--HTSIHILNVDTSDIGEYHCKA 5591
Query: 314 ENILGKDT 321
+N +G DT
Sbjct: 5592 QNEVGSDT 5599
Score = 43.1 bits (100), Expect = 0.001
Identities = 28/86 (32%), Positives = 44/86 (51%), Gaps = 8/86 (9%)
Query: 241 KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK 300
K++ TG ++ L+CE + + +WFKDGKE+ S++ IK +G+K L K
Sbjct: 12023 KLQDYTGVEKDEVILQCEISKADAP--VKWFKDGKEIKPSKNAVIK-ADGKKR-MLILKK 12078
Query: 301 VKVEDAGEYVCEAENILGKDTVRGRL 326
D G+Y C+ G D G+L
Sbjct: 12079 ALKSDIGQYTCDC----GTDKTSGKL 12100
Score = 42.7 bits (99), Expect = 0.001
Identities = 20/61 (32%), Positives = 35/61 (57%), Gaps = 2/61 (3%)
Query: 261 AGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKD 320
AG P+ +W+KDG+ L S+ RI + N ++L+F ++ D+G+Y E N +G
Sbjct: 4041 AGTPELKPKWYKDGRPLVASKKYRISFKN--NVAQLKFYSAELHDSGQYTFEISNEVGSS 4098
Query: 321 T 321
+
Sbjct: 4099 S 4099
Score = 42.7 bits (99), Expect = 0.001
Identities = 29/88 (32%), Positives = 44/88 (50%), Gaps = 7/88 (7%)
Query: 241 KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK 300
K+ +T ++ +LKCE + P +WFKDG+E+ S IK R+ L+ K
Sbjct: 11668 KLHDKTAVEKDEITLKCEVSKDVP---VKWFKDGEEIVPSPKYSIKADGLRR--ILKIKK 11722
Query: 301 VKVEDAGEYVCE--AENILGKDTVRGRL 326
++D GEYVC+ + TV RL
Sbjct: 11723 ADLKDKGEYVCDCGTDKTKANVTVEARL 11750
Score = 42.4 bits (98), Expect = 0.002
Identities = 22/70 (31%), Positives = 39/70 (55%), Gaps = 3/70 (4%)
Query: 249 VGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGE 308
+GE +L+C+ G P+ W+K+ +L + ++++ N + L NKV D GE
Sbjct: 7033 IGEPATLQCKVD-GTPEIRISWYKEHTKLRSAPAYKMQFKNNVAS--LVINKVDHSDVGE 7089
Query: 309 YVCEAENILG 318
Y C+A+N +G
Sbjct: 7090 YSCKADNSVG 7099
Score = 42.4 bits (98), Expect = 0.002
Identities = 31/102 (30%), Positives = 43/102 (42%), Gaps = 9/102 (8%)
Query: 224 EVGKILCT------DCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQP-SYRWFKDGKE 276
EVGK CT + P K S+T + E S K E QP + W+K+ E
Sbjct: 8230 EVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIE 8289
Query: 277 LNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILG 318
+ + + I + N LQ K + DAG Y C+ N G
Sbjct: 8290 IQPTSNCEITFKNN--TLVLQVRKAGMNDAGLYTCKVSNDAG 8329
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/93 (30%), Positives = 44/93 (47%), Gaps = 5/93 (5%)
Query: 238 KLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQ 297
+++ +K + QV EKQ E W+KDG E+N R KY R+ R+
Sbjct: 3148 RIRSIKKEV-QVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMF 3206
Query: 298 FNKVKVEDAGEYVCEAENILGKDTVRGRLYVNS 330
++ + DAGEY + G++ LYVN+
Sbjct: 3207 ISETRQSDAGEYTF----VAGRNRSSVTLYVNA 3235
Score = 42.0 bits (97), Expect = 0.002
Identities = 39/155 (25%), Positives = 63/155 (40%), Gaps = 6/155 (3%)
Query: 206 VFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK-KMKSQTGQVGEKQSLKCEAAAGNP 264
V TA L+ L + + + + + P +K K++ +G CE + P
Sbjct: 3425 VSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSA-P 3483
Query: 265 QPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRG 324
++WFK G+E+ S I+ + + S L+ + +V D GEY C+A N G +
Sbjct: 3484 NVRFQWFKAGREIYESDKCSIR--SSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTA 3541
Query: 325 RLYVNSV--STTLSSWSGHARKCNETAKSYCVNGG 357
L V T LS + AK C G
Sbjct: 3542 TLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTG 3576
Score = 42.0 bits (97), Expect = 0.002
Identities = 27/87 (31%), Positives = 43/87 (49%), Gaps = 3/87 (3%)
Query: 243 KSQTGQVGEKQSLKCEAAAGNPQP-SYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKV 301
K Q+ V ++ +A G P + +WFKD KEL+ S R + + S L+
Sbjct: 4773 KPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELH-SGAARSVWKDDTSTS-LELFAA 4830
Query: 302 KVEDAGEYVCEAENILGKDTVRGRLYV 328
K D+G Y+C+ N +G T + L+V
Sbjct: 4831 KATDSGTYICQLSNDVGTATSKATLFV 4857
Score = 42.0 bits (97), Expect = 0.002
Identities = 19/57 (33%), Positives = 32/57 (56%), Gaps = 2/57 (3%)
Query: 262 GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILG 318
G+P+ W+KD E+ S R+ + + + L+ + + VED+G+Y CEA N G
Sbjct: 7331 GSPEIKVLWYKDETEIQESSKFRMSFVDSV--AVLEMHNLSVEDSGDYTCEAHNAAG 7385
Score = 41.6 bits (96), Expect = 0.003
Identities = 50/203 (24%), Positives = 84/203 (41%), Gaps = 25/203 (12%)
Query: 139 VPAGGSSSNSTREPPAS-GRVALVKVLD-----KW--PLRSGG---------LQREQVIS 181
+PA + EPP GRV LV V KW P GG +Q +
Sbjct: 25282 LPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEK 25341
Query: 182 VGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVG-KILCTDCATRPKLK 240
+C ++ + I L E+ VF+ A ++ G++ +++G ++ D +P ++
Sbjct: 25342 WSTCTQVKTLEATISGLTAGEE-YVFRVA--AVNEKGRSDPRQLGVPVIARDIEIKPSVE 25398
Query: 241 KMKSQTGQVGEKQSLKCEAA-AGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFN 299
+ T V ++ LK + G PQ + W KDG+ L + R+ + + + L
Sbjct: 25399 -LPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKET--TRVNVSSSKTVTSLSIK 25455
Query: 300 KVKVEDAGEYVCEAENILGKDTV 322
+ ED G Y N G TV
Sbjct: 25456 EASKEDVGTYELCVSNSAGSITV 25478
Score = 41.6 bits (96), Expect = 0.003
Identities = 24/90 (26%), Positives = 41/90 (45%), Gaps = 3/90 (3%)
Query: 239 LKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQF 298
+ + +SQ G+ CE + G P P WFK+ ++ S ++ I R L+
Sbjct: 33137 ISQPRSQNINEGQNVLFTCEIS-GEPSPEIEWFKNNLPISISSNVSIS--RSRNVYSLEI 33193
Query: 299 NKVKVEDAGEYVCEAENILGKDTVRGRLYV 328
V D+G+Y +A+N G+ + L V
Sbjct: 33194 RNASVSDSGKYTIKAKNFRGQCSATASLMV 33223
Score = 41.2 bits (95), Expect = 0.004
Identities = 24/69 (34%), Positives = 34/69 (49%), Gaps = 3/69 (4%)
Query: 261 AGNPQPSYRWFKDGKELNRSRDIRIKY-GNGRKNSRLQFNKVKVEDAGEYVCEAENILGK 319
+G P P W+KDGK + ++ + +GR + R+ V ED G Y A NI G
Sbjct: 1315 SGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPV--VLPEDEGIYTAFASNIKGN 1372
Query: 320 DTVRGRLYV 328
G+LYV
Sbjct: 1373 AICSGKLYV 1381
Score = 40.8 bits (94), Expect = 0.005
Identities = 28/90 (31%), Positives = 43/90 (47%), Gaps = 3/90 (3%)
Query: 239 LKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQF 298
L++++ T Q G K + C +G PQP W+K+ + L S + K+ + + L
Sbjct: 3242 LQELQPVTVQSG-KPARFCAVISGRPQPKISWYKEEQLL--STGFKCKFLHDGQEYTLLL 3298
Query: 299 NKVKVEDAGEYVCEAENILGKDTVRGRLYV 328
+ EDA Y CEA+N G T L V
Sbjct: 3299 IEAFPEDAAVYTCEAKNDYGVATTSASLSV 3328
Score = 40.8 bits (94), Expect = 0.005
Identities = 30/101 (29%), Positives = 46/101 (45%), Gaps = 7/101 (6%)
Query: 225 VGKILCTDCAT---RPKLKKMKSQTGQV-GEKQSLKCEAAAGNPQPSYRWFKDGKELNRS 280
VG C+ T P + S G + G L+CE + G P W KD K++ S
Sbjct: 6443 VGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEIS-GTPPFEVVWVKDRKQVRNS 6501
Query: 281 RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDT 321
+ +I + ++ L ++ D GEY C+A N +G DT
Sbjct: 6502 KKFKIT--SKHFDTSLHILNLEASDVGEYHCKATNEVGSDT 6540
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/139 (24%), Positives = 56/139 (40%), Gaps = 10/139 (7%)
Query: 197 FLEPTEQPLVFKT------AFAPLDTNGKNLKKEVGKILCTDCATRPKLK-KMKSQTGQV 249
FL+ T +FKT ++ TN +++ T+ P ++ V
Sbjct: 8107 FLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVV 8166
Query: 250 GEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEY 309
GE +C P W KD +E+ +I Y ++ L KV D+G+Y
Sbjct: 8167 GESADFECHVTGTQPI-KVSWAKDSREIRSGGKYQISYLEN--SAHLTVLKVDKGDSGQY 8223
Query: 310 VCEAENILGKDTVRGRLYV 328
C A N +GKD+ +L +
Sbjct: 8224 TCYAVNEVGKDSCTAQLNI 8242
Score = 40.4 bits (93), Expect = 0.007
Identities = 31/112 (27%), Positives = 50/112 (44%), Gaps = 7/112 (6%)
Query: 221 LKKEVGKILCTDC----ATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKE 276
+ E GK CT A +K++ + + G+ L+ G P S W K+G
Sbjct: 7849 VSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILE-GTFTGTPPISVTWKKNGIN 7907
Query: 277 LNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV 328
+ S+ R K++ L+ VEDAG+Y C EN GKD+ ++ +
Sbjct: 7908 VTPSQ--RCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILI 7957
Score = 40.4 bits (93), Expect = 0.007
Identities = 38/159 (23%), Positives = 60/159 (37%), Gaps = 17/159 (10%)
Query: 161 VKVLDKWPLRSGGLQREQVISVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKN 220
+K D W G +E V CV NQ Y F ++ + G++
Sbjct: 18141 LKGSDDWERVHKGSIKETHYMVDRCV---ENQIYEFRVQTKNE-------------GGES 18184
Query: 221 LKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAA-GNPQPSYRWFKDGKELNR 279
+ +++ + +P L S V +++ EA G P P W KD +
Sbjct: 18185 DWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDL 18244
Query: 280 SRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILG 318
+R R+K +S+ K K D G+YV A N G
Sbjct: 18245 TRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAG 18283
Score = 40.0 bits (92), Expect = 0.009
Identities = 22/83 (26%), Positives = 44/83 (53%), Gaps = 3/83 (3%)
Query: 239 LKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQF 298
+K+++ + +K L+C+ + + W KDG++L +D +I + + K + L+
Sbjct: 3647 IKELEPVQSAINKKVHLECQVDEDR-KVTVTWSKDGQKLPPGKDYKICFED--KIATLEI 3703
Query: 299 NKVKVEDAGEYVCEAENILGKDT 321
K++D+G YVC A N G +
Sbjct: 3704 PLAKLKDSGTYVCTASNEAGSSS 3726
Score = 40.0 bits (92), Expect = 0.009
Identities = 21/69 (30%), Positives = 36/69 (52%), Gaps = 3/69 (4%)
Query: 250 GEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEY 309
G+ + +C+ G P+ W+ DG E+ + I + +G + Q + +VE++G Y
Sbjct: 4876 GQSTTFECQIT-GTPKIRVSWYLDGNEITAIQKHGISFIDGL--ATFQISGARVENSGTY 4932
Query: 310 VCEAENILG 318
VCEA N G
Sbjct: 4933 VCEARNDAG 4941
Score = 40.0 bits (92), Expect = 0.009
Identities = 26/80 (32%), Positives = 35/80 (43%), Gaps = 5/80 (6%)
Query: 250 GEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIK-YGNGRKNSRLQFNKVKVEDAGE 308
GE +C P W KD KE+ + I GN L+ KV D+G+
Sbjct: 6285 GESADFECHVTGAQPM-RITWSKDNKEIRPGGNYTITCVGN---TPHLRILKVGKGDSGQ 6340
Query: 309 YVCEAENILGKDTVRGRLYV 328
Y C+A N +GKD +L V
Sbjct: 6341 YTCQATNDVGKDMCSAQLSV 6360
Score = 40.0 bits (92), Expect = 0.009
Identities = 25/77 (32%), Positives = 35/77 (45%), Gaps = 3/77 (3%)
Query: 250 GEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEY 309
G L+CE G P W+KD +EL + +I N + + V D GEY
Sbjct: 7413 GADVHLECELQ-GTPPFHVSWYKDKRELRSGKKYKIMSENFLTS--IHILNVDAADIGEY 7469
Query: 310 VCEAENILGKDTVRGRL 326
C+A N +G DT G +
Sbjct: 7470 QCKATNDVGSDTCVGSI 7486
Score = 40.0 bits (92), Expect = 0.009
Identities = 29/96 (30%), Positives = 45/96 (46%), Gaps = 6/96 (6%)
Query: 228 ILCTDCATRPKLKK-MKSQTGQVGEKQSLKCEAA-AGNPQPSYRWFKDGKELNRSRDIRI 285
I+ D P +K S + QVG Q LK E +G P+P+ W KDG L ++ RI
Sbjct: 23221 IVAKDLVIEPDVKPAFSSYSVQVG--QDLKIEVPISGRPKPTITWTKDGLPLKQT--TRI 23276
Query: 286 KYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDT 321
+ + L + +D G+Y N++G+ T
Sbjct: 23277 NVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKT 23312
Score = 40.0 bits (92), Expect = 0.009
Identities = 20/75 (26%), Positives = 35/75 (46%), Gaps = 2/75 (2%)
Query: 260 AAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGK 319
A G P+P+ W KDGK + + ++ G L+ +K D+G Y C +N G
Sbjct: 32875 ATGEPRPTAIWTKDGKAITQGGKYKLSEDKG--GFFLEIHKTDTSDSGLYTCTVKNSAGS 32932
Query: 320 DTVRGRLYVNSVSTT 334
+ +L + ++ T
Sbjct: 32933 VSSSCKLTIKAIKDT 32947
Score = 39.7 bits (91), Expect = 0.012
Identities = 25/80 (31%), Positives = 36/80 (45%), Gaps = 3/80 (3%)
Query: 249 VGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGE 308
+GE + KC G W KD +E+ + ++ + L KV DAG+
Sbjct: 7225 LGESGTFKCHVT-GTAPIKITWAKDNREIRPGGNYKMTLVEN--TATLTVLKVGKGDAGQ 7281
Query: 309 YVCEAENILGKDTVRGRLYV 328
Y C A NI GKD+ +L V
Sbjct: 7282 YTCYASNIAGKDSCSAQLGV 7301
Score = 39.7 bits (91), Expect = 0.012
Identities = 33/120 (27%), Positives = 51/120 (42%), Gaps = 4/120 (3%)
Query: 239 LKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRD-IRIKYGNGRKNSRLQ 297
+KK+ + VG++ L+ P S WFKD E+ R D I I Y + LQ
Sbjct: 7495 VKKLSDISTVVGKEVQLQTTIEGAEPI-SVVWFKDKGEIVRESDNIWISYSENI--ATLQ 7551
Query: 298 FNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGG 357
F++V+ +AG+Y C+ +N G L V +T + +T C G
Sbjct: 7552 FSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAG 7611
Score = 39.3 bits (90), Expect = 0.015
Identities = 31/116 (26%), Positives = 53/116 (45%), Gaps = 11/116 (9%)
Query: 224 EVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAA------GNPQPSYRWFKDGKEL 277
EVG +C+ R L++ S ++ SL+ AA G+ + W KD E+
Sbjct: 4470 EVGSSICS---ARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEI 4526
Query: 278 NRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVST 333
+IR+ + N + L + ++V+ G+YVC+A+N G L V +T
Sbjct: 4527 TEDDNIRMTFENNVAS--LYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPAT 4580
Score = 39.3 bits (90), Expect = 0.015
Identities = 32/101 (31%), Positives = 52/101 (51%), Gaps = 12/101 (11%)
Query: 222 KKEVGKILCTDCATRPK-----LKKMKSQTGQVGEKQSLKCEAAAGNPQPSY-RWFKDGK 275
+ EVG C C + K + K+ S T GE L +A+ QP + +W K+ +
Sbjct: 5592 QNEVGSDTCV-CTVKLKEPPRFVSKLNSLTVVAGEPAEL--QASIEGAQPIFVQWLKEKE 5648
Query: 276 ELNR-SRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAEN 315
E+ R S +IRI + + LQF K + +AG+Y+C+ +N
Sbjct: 5649 EVIRESENIRITFVENV--ATLQFAKAEPANAGKYICQIKN 5687
Score = 39.3 bits (90), Expect = 0.015
Identities = 30/99 (30%), Positives = 44/99 (44%), Gaps = 3/99 (3%)
Query: 231 TDCATRPKLKKMKSQTGQVGEKQSLKCEA-AAGNPQPSYRWFKDGKELNRSRDIRIKYGN 289
TD RP K++ + + E QS+ E +G P P+ +W KDG+ L+ +I I +
Sbjct: 31789 TDSTLRPMFKRLLANA-ECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIH-E 31846
Query: 290 GRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV 328
G L ED G Y A N G + + L V
Sbjct: 31847 GLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQV 31885
Score = 38.9 bits (89), Expect = 0.020
Identities = 29/107 (27%), Positives = 44/107 (41%), Gaps = 10/107 (9%)
Query: 221 LKKEVGKILCT------DCATRPK-LKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKD 273
+K VGK CT D P ++K+K +G L+C + P S WF+D
Sbjct: 6719 VKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPI-SVGWFQD 6777
Query: 274 GKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKD 320
G E+ + + L + ++ D G Y C A N+ G D
Sbjct: 6778 GNEIVSGPKCQSSFSENV--CTLNLSLLEPSDTGIYTCVAANVAGSD 6822
Score = 38.9 bits (89), Expect = 0.020
Identities = 18/58 (31%), Positives = 29/58 (50%), Gaps = 2/58 (3%)
Query: 261 AGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILG 318
AG P P+ WF G +L S + ++ K ++L + + D GEY E +N+ G
Sbjct: 29763 AGRPPPAASWFFAGSKLRESERVTVE--THTKVAKLTIRETTIRDTGEYTLELKNVTG 29818
Score = 38.5 bits (88), Expect = 0.026
Identities = 20/68 (29%), Positives = 37/68 (54%), Gaps = 2/68 (2%)
Query: 261 AGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKD 320
+G + + +WFKDG+EL +I + S L+ + +D+GEY E +N +G+
Sbjct: 4603 SGTKEITAKWFKDGQELTLGSKYKISVTD--TVSILKIISTEKKDSGEYTFEVQNDVGRS 4660
Query: 321 TVRGRLYV 328
+ + R+ V
Sbjct: 4661 SCKARINV 4668
Score = 38.5 bits (88), Expect = 0.026
Identities = 33/106 (31%), Positives = 47/106 (44%), Gaps = 12/106 (11%)
Query: 250 GEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEY 309
GEK S+ A P P+ W KDGKE+ S + +K N ++ L+ K DAG Y
Sbjct: 14401 GEKLSIPVPFRAV-PVPTVSWHKDGKEVKASDRLTMK--NDHISAHLEVPKSVRADAGIY 14457
Query: 310 VCEAENILGKDTVRGRLYVNSVSTTLSSWSGHAR--KCNETAKSYC 353
EN LG T S++ + G + K ++ KS C
Sbjct: 14458 TITLENKLGSATA-------SINVKVIGLPGPCKDIKASDITKSSC 14496
Score = 38.5 bits (88), Expect = 0.026
Identities = 26/96 (27%), Positives = 38/96 (39%), Gaps = 3/96 (3%)
Query: 239 LKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQF 298
L K +S T GE C+ G P P+ W + G+ L+ S R + + S +
Sbjct: 32564 LTKPRSMTVYEGESARFSCDTD-GEPVPTVTWLRKGQVLSTSA--RHQVTTTKYKSTFEI 32620
Query: 299 NKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTT 334
+ V+ D G Y EN GK L + T
Sbjct: 32621 SSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVT 32656
Score = 37.7 bits (86), Expect = 0.045
Identities = 24/70 (34%), Positives = 35/70 (50%), Gaps = 4/70 (5%)
Query: 240 KKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFN 299
K + QT ++ +CE A NP W +DGK L + +IR + +G K RL
Sbjct: 2624 KPLTDQTVAESQEAVFECEVA--NPDSKGEWLRDGKHLPLTNNIRSE-SDGHKR-RLIIA 2679
Query: 300 KVKVEDAGEY 309
K++D GEY
Sbjct: 2680 ATKLDDIGEY 2689
Score = 37.7 bits (86), Expect = 0.045
Identities = 30/92 (32%), Positives = 40/92 (43%), Gaps = 7/92 (7%)
Query: 228 ILCTDCATRPKLK---KMKSQTG-QVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDI 283
I C D PK+K K K + GE L+ + + G P P+ W KDGKEL + +
Sbjct: 21450 ITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVS-GRPPPTMEWSKDGKELEGTAKL 21508
Query: 284 RIKYGNGRKNSRLQFNKVKVEDAGEYVCEAEN 315
IK + N L D+G Y A N
Sbjct: 21509 EIKIADFSTN--LVNKDSTRRDSGAYTLTATN 21538
Score = 37.7 bits (86), Expect = 0.045
Identities = 22/86 (25%), Positives = 40/86 (46%), Gaps = 2/86 (2%)
Query: 244 SQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS-RDIRIKYGNGRKNSRLQFNKVK 302
++T VGE +P+P W+K G+++ D + + + + +L N V
Sbjct: 31698 NKTAYVGENVRFGVTITV-HPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVT 31756
Query: 303 VEDAGEYVCEAENILGKDTVRGRLYV 328
+D EY A N G+D+ + +L V
Sbjct: 31757 TDDDAEYTVVARNKYGEDSCKAKLTV 31782
Score = 37.4 bits (85), Expect = 0.059
Identities = 29/114 (25%), Positives = 50/114 (43%), Gaps = 4/114 (3%)
Query: 216 TNGKNLKKEVGKILCTDCATRPK-LKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDG 274
TNG ++L P +++++S T + G + L+ G P P ++++DG
Sbjct: 83 TNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVT-GIPTPVVKFYRDG 141
Query: 275 KELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV 328
E+ S D +I + L + ED+G Y A N +G+ T L V
Sbjct: 142 AEIQSSLDFQISQEGDLYS--LLIAEAYPEDSGTYSVNATNSVGRATSTAELLV 193
Score = 37.4 bits (85), Expect = 0.059
Identities = 22/90 (24%), Positives = 43/90 (47%), Gaps = 1/90 (1%)
Query: 239 LKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQF 298
++K+K+ + G + +K A GNP P W K+ + + +I+ + + L+
Sbjct: 1559 VEKLKNVNIKEGSRLEMKVRAT-GNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKI 1617
Query: 299 NKVKVEDAGEYVCEAENILGKDTVRGRLYV 328
+ +D+ Y A N G+DT R ++ V
Sbjct: 1618 DSTVSQDSAWYTATAINKAGRDTTRCKVNV 1647
Score = 37.4 bits (85), Expect = 0.059
Identities = 28/106 (26%), Positives = 48/106 (45%), Gaps = 5/106 (4%)
Query: 218 GKNLKKEVG-KILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAA-GNPQPSYRWFKDGK 275
GK+ + +G ++ D +P LK + T + + LK E G P+P+ W KDG+
Sbjct: 24292 GKSDPRVLGVPVIAKDLTIQPSLK-LPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGE 24350
Query: 276 ELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDT 321
L ++ R+ ++ L + +D G+Y A N G T
Sbjct: 24351 PLKQT--TRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTAT 24394
Score = 37.0 bits (84), Expect = 0.077
Identities = 23/76 (30%), Positives = 40/76 (52%), Gaps = 4/76 (5%)
Query: 240 KKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFN 299
K ++ QT + G L+CE + N + +WFK+G E+ +S+ I +GR +L +
Sbjct: 12289 KPLEDQTVEEGATAVLECEVSRENAK--VKWFKNGTEILKSKKYEI-VADGRVR-KLVIH 12344
Query: 300 KVKVEDAGEYVCEAEN 315
ED Y C+A++
Sbjct: 12345 DCTPEDIKTYTCDAKD 12360
Score = 36.6 bits (83), Expect = 0.10
Identities = 22/67 (32%), Positives = 31/67 (46%), Gaps = 6/67 (8%)
Query: 248 QVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNS--RLQFNKVKVED 305
QV EK+ + E +WFKDG E+ + + KY K + L NK ++D
Sbjct: 12384 QVREKEMARFECELSRENAKVKWFKDGAEIKKGK----KYDIISKGAVRILVINKCLLDD 12439
Query: 306 AGEYVCE 312
EY CE
Sbjct: 12440 EAEYSCE 12446
Score = 36.2 bits (82), Expect = 0.13
Identities = 32/109 (29%), Positives = 47/109 (43%), Gaps = 7/109 (6%)
Query: 224 EVGKILC--TDCATRPK--LKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNR 279
EVGK C T P +KK+ G+ +L+ A G+ S W K + +
Sbjct: 3908 EVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQA-AVRGSEPISVTWMKGQEVIRE 3966
Query: 280 SRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV 328
I++ + NG + L V++ G+Y C AEN G T G L V
Sbjct: 3967 DGKIKMSFSNGV--AVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIV 4013
Score = 36.2 bits (82), Expect = 0.13
Identities = 22/72 (30%), Positives = 30/72 (41%), Gaps = 2/72 (2%)
Query: 262 GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDT 321
G+ + RWFK KEL I S L+ VK D+G Y C+ N+ G
Sbjct: 4231 GSTPLTIRWFKGNKELVSGGSCYIT--KEALESSLELYLVKTSDSGTYTCKVSNVAGGVE 4288
Query: 322 VRGRLYVNSVST 333
L+V +T
Sbjct: 4289 CSANLFVKEPAT 4300
Score = 36.2 bits (82), Expect = 0.13
Identities = 20/81 (24%), Positives = 35/81 (43%), Gaps = 2/81 (2%)
Query: 262 GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDT 321
G P WF+ +EL + I + + + L+ + + +GEY C N G+ +
Sbjct: 5918 GTPPFKVNWFRGARELVKGDRCNIYFED--TVAELELFNIDISQSGEYTCVVSNNAGQAS 5975
Query: 322 VRGRLYVNSVSTTLSSWSGHA 342
RL+V + L S H+
Sbjct: 5976 CTTRLFVKEPAAFLKRLSDHS 5996
Score = 35.4 bits (80), Expect = 0.22
Identities = 18/65 (27%), Positives = 26/65 (40%)
Query: 262 GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDT 321
GNP+P W K G L ++ Y +L + +DAGEY N G+ +
Sbjct: 1107 GNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETS 1166
Query: 322 VRGRL 326
L
Sbjct: 1167 ASASL 1171
Score = 35.4 bits (80), Expect = 0.22
Identities = 26/92 (28%), Positives = 41/92 (44%), Gaps = 8/92 (8%)
Query: 233 CATRPKLKKMKS------QTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIK 286
C+TR LK+ S T V + + AG+P S W KD + L+ ++ I
Sbjct: 5038 CSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYIS 5097
Query: 287 YGNGRKNSRLQFNKVKVEDAGEYVCEAENILG 318
+ + + LQ V +G Y C+A+N G
Sbjct: 5098 FVD--SVATLQIRSVDNGHSGRYTCQAKNESG 5127
Score = 35.4 bits (80), Expect = 0.22
Identities = 21/68 (30%), Positives = 33/68 (48%), Gaps = 2/68 (2%)
Query: 259 AAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILG 318
A +G+ S W+KDGK L S +++ + + + L K AG+Y C A N +G
Sbjct: 8079 AISGSEPISVSWYKDGKPLKDSPNVQTSFLD--NTATLNIFKTDRSLAGQYSCTATNPIG 8136
Query: 319 KDTVRGRL 326
+ RL
Sbjct: 8137 SASSSARL 8144
Score = 35.4 bits (80), Expect = 0.22
Identities = 25/104 (24%), Positives = 43/104 (41%), Gaps = 6/104 (5%)
Query: 223 KEVGKILCTDCATRPKLK---KMKSQTGQVGEKQSLKCEAAAGN-PQPSYRWFKDGKELN 278
+ G + C D PK + ++ + L +AA G P+P W K KEL+
Sbjct: 29030 ESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELD 29089
Query: 279 RSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTV 322
+ ++Y R + ++F D+G+Y +N G V
Sbjct: 29090 LCEKVSLQYTGKRATAVIKF--CDRSDSGKYTLTVKNASGTKAV 29131
Score = 35.0 bits (79), Expect = 0.29
Identities = 21/72 (29%), Positives = 37/72 (51%), Gaps = 4/72 (5%)
Query: 261 AGNPQPSYRWFKDGKELNRSR--DIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILG 318
+G P P WF+DG+ ++ S ++I + +GR ++L V ++G Y +A N G
Sbjct: 30 SGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR--AKLTIPAVTKANSGRYSLKATNGSG 87
Query: 319 KDTVRGRLYVNS 330
+ T L V +
Sbjct: 88 QATSTAELLVKA 99
Score = 35.0 bits (79), Expect = 0.29
Identities = 16/43 (37%), Positives = 23/43 (53%), Gaps = 1/43 (2%)
Query: 270 WFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCE 312
W+KDGK+L + + Y + L+ N + D GEYVCE
Sbjct: 32751 WYKDGKKLKENGHFQFHY-SADGTYELKINNLTESDQGEYVCE 32792
Score = 34.7 bits (78), Expect = 0.38
Identities = 22/67 (32%), Positives = 30/67 (44%), Gaps = 2/67 (2%)
Query: 262 GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDT 321
G P P+ W KDG L + IK R L+ V +D+G+Y AEN G +
Sbjct: 19321 GKPMPTVSWKKDGTLLKPAEG--IKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKS 19378
Query: 322 VRGRLYV 328
+L V
Sbjct: 19379 ATIKLKV 19385
Score = 34.7 bits (78), Expect = 0.38
Identities = 20/58 (34%), Positives = 27/58 (46%), Gaps = 2/58 (3%)
Query: 262 GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGK 319
G P P+ W KD K L D R N +S L +V D G+Y+ EN +G+
Sbjct: 27297 GRPPPTVTWRKDEKNLGS--DARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGE 27352
Score = 34.3 bits (77), Expect = 0.50
Identities = 20/66 (30%), Positives = 29/66 (43%), Gaps = 4/66 (6%)
Query: 250 GEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEY 309
GE +C G PQP W+ +G+ + +S+ R++Y L K D GE
Sbjct: 1855 GETARFRCRVT-GYPQPKVNWYLNGQLIRKSKRFRVRYDG---IHYLDIVDCKSYDTGEV 1910
Query: 310 VCEAEN 315
AEN
Sbjct: 1911 KVTAEN 1916
Score = 34.3 bits (77), Expect = 0.50
Identities = 28/93 (30%), Positives = 45/93 (48%), Gaps = 5/93 (5%)
Query: 237 PKLKKMKSQTGQVGEKQSLKCEAAA-GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSR 295
PK+ + T + G+K L+ EA G P P+ +W K E+ S + + + +S
Sbjct: 18900 PKILMPEQITIKAGKK--LRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADS--SSI 18955
Query: 296 LQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV 328
L V +D+G Y AEN G DT + ++ V
Sbjct: 18956 LIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVV 18988
Score = 34.3 bits (77), Expect = 0.50
Identities = 21/71 (29%), Positives = 42/71 (59%), Gaps = 3/71 (4%)
Query: 253 QSLKCEAAA-GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVC 311
+S K +A G P P+ +W K +EL+ + + IK + + ++ + V+V D+G Y+
Sbjct: 22559 ESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFATSLSVK-DAVRV-DSGNYIL 22616
Query: 312 EAENILGKDTV 322
+A+N+ G+ +V
Sbjct: 22617 KAKNVAGERSV 22627
Score = 33.9 bits (76), Expect = 0.65
Identities = 28/105 (26%), Positives = 45/105 (42%), Gaps = 3/105 (2%)
Query: 227 KILCTDCATRPKL-KKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRI 285
KI + PK+ ++++SQT G + G P P W+K+G ++ RS D
Sbjct: 2068 KIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVV-GKPDPECEWYKNGVKIERS-DRIY 2125
Query: 286 KYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNS 330
Y L V ED+ + +A NI G+ + L V +
Sbjct: 2126 WYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA 2170
Score = 33.9 bits (76), Expect = 0.65
Identities = 22/96 (22%), Positives = 40/96 (41%), Gaps = 2/96 (2%)
Query: 237 PKLKKMKSQTG-QVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSR 295
PK++ + S G+ ++ C A G P P W G++++ R N +
Sbjct: 33329 PKIEALPSDISIDEGKVLTVAC-AFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTT 33387
Query: 296 LQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSV 331
L V+ +D G Y N G D+ +++ S+
Sbjct: 33388 LIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIRSI 33423
Score = 33.1 bits (74), Expect = 1.1
Identities = 21/70 (30%), Positives = 31/70 (44%), Gaps = 3/70 (4%)
Query: 250 GEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEY 309
G L+CE + P WFKD K++ S+ R+ + + L+ D GEY
Sbjct: 3845 GTNALLQCEVSGTGPF-EISWFKDKKQIRSSKKYRLF--SQKSLVCLEIFSFNSADVGEY 3901
Query: 310 VCEAENILGK 319
C N +GK
Sbjct: 3902 ECVVANEVGK 3911
Score = 33.1 bits (74), Expect = 1.1
Identities = 25/89 (28%), Positives = 34/89 (38%), Gaps = 9/89 (10%)
Query: 261 AGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKD 320
AG P WFKD L R + + + LQ K DAGEY C N +G
Sbjct: 4417 AGTPPFEITWFKDNTILRSGRKYKTFIQDHLVS--LQILKFVAADAGEYQCRVTNEVGSS 4474
Query: 321 TVRGRL-------YVNSVSTTLSSWSGHA 342
R+ ++ + +T S G A
Sbjct: 4475 ICSARVTLREPPSFIKKIESTSSLRGGTA 4503
Score = 33.1 bits (74), Expect = 1.1
Identities = 26/101 (25%), Positives = 48/101 (47%), Gaps = 10/101 (9%)
Query: 224 EVGKILCTDCATRPK-----LKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKD-GKEL 277
EVG C+ C+ + K +KK+ + +G+ L+ P S W KD G+ +
Sbjct: 6535 EVGSDTCS-CSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPI-SVVWLKDRGEVI 6592
Query: 278 NRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILG 318
S + RI + + + LQ + ++G+Y+C+ +N G
Sbjct: 6593 RESENTRISFIDNI--ATLQLGSPEASNSGKYICQIKNDAG 6631
Score = 33.1 bits (74), Expect = 1.1
Identities = 17/54 (31%), Positives = 22/54 (40%), Gaps = 2/54 (3%)
Query: 262 GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAEN 315
G P+PS W KDG L S +R + L K E G+Y +N
Sbjct: 27589 GKPKPSISWLKDGLPLKESEFVR--FSKTENKITLSIKNAKKEHGGKYTVILDN 27640
Score = 33.1 bits (74), Expect = 1.1
Identities = 24/61 (39%), Positives = 29/61 (47%), Gaps = 4/61 (6%)
Query: 259 AAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILG 318
+ +G P P W K G +L SR I S L +KV DAG+Y EAEN G
Sbjct: 29469 SVSGRPPPVITWSKQGIDL-ASRAI---IDTTESYSLLIVDKVNRYDAGKYTIEAENQSG 29524
Query: 319 K 319
K
Sbjct: 29525 K 29525
Score = 32.7 bits (73), Expect = 1.4
Identities = 24/82 (29%), Positives = 34/82 (41%), Gaps = 3/82 (3%)
Query: 239 LKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQF 298
LK++ + + G+ L+ G S W KDG + S I K L+
Sbjct: 5989 LKRLSDHSVEPGKSIILE-STYTGTLPISVTWKKDGFNITTSEKCNIV--TTEKTCILEI 6045
Query: 299 NKVKVEDAGEYVCEAENILGKD 320
DAG+Y CE EN G+D
Sbjct: 6046 LNSTKRDAGQYSCEIENEAGRD 6067
Score = 32.7 bits (73), Expect = 1.4
Identities = 18/57 (31%), Positives = 26/57 (45%), Gaps = 2/57 (3%)
Query: 262 GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILG 318
G P+P W K+GK L R + R+ LQ + D G+Y+ A+N G
Sbjct: 17934 GRPEPDITWTKEGKVLVREK--RVDLIQDLPRVELQIKEAVRADHGKYIISAKNSSG 17988
Score = 32.3 bits (72), Expect = 1.9
Identities = 24/84 (28%), Positives = 34/84 (40%), Gaps = 3/84 (3%)
Query: 237 PKLKKMKSQTGQVGEKQSLKCEAA-AGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSR 295
P K+ T V + LK + G P P+ W KD L ++ R+ + NS
Sbjct: 22147 PPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTT--RVNAESTENNSL 22204
Query: 296 LQFNKVKVEDAGEYVCEAENILGK 319
L ED G YV + N G+
Sbjct: 22205 LTIKDACREDVGHYVVKLTNSAGE 22228
Score = 32.0 bits (71), Expect = 2.5
Identities = 21/67 (31%), Positives = 32/67 (47%), Gaps = 3/67 (4%)
Query: 253 QSLKCEAAA-GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVC 311
+SL+ +A G P P WFKDG E+ + ++ I G ++ L + G Y
Sbjct: 27974 ESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLG--STSLFVRDATRDHRGVYTV 28031
Query: 312 EAENILG 318
EA+N G
Sbjct: 28032 EAKNASG 28038
Score = 31.6 bits (70), Expect = 3.2
Identities = 21/70 (30%), Positives = 27/70 (38%), Gaps = 2/70 (2%)
Query: 262 GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDT 321
G P P+ +W DG E+ ++ N +S L D GEY N G T
Sbjct: 17536 GVPVPTAKWTTDGSEIKTDEHYTVETDN--FSSVLTIKNCLRRDTGEYQITVSNAAGSKT 17593
Query: 322 VRGRLYVNSV 331
V L V V
Sbjct: 17594 VAVHLTVLDV 17603
Score = 31.2 bits (69), Expect = 4.2
Identities = 23/90 (25%), Positives = 38/90 (42%), Gaps = 6/90 (6%)
Query: 248 QVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAG 307
+V EK+ E P + +W KD +EL + RIK + RL ++ DAG
Sbjct: 3068 KVLEKKRAMFECEVSEPDITVQWMKDDQELQITD--RIKIQKEKYVHRLLIPSTRMSDAG 3125
Query: 308 EYVCEAENILGKDTVRGRLYVNSVSTTLSS 337
+Y + G + +L+V + S
Sbjct: 3126 KYTV----VAGGNVSTAKLFVEGRDVRIRS 3151
Score = 31.2 bits (69), Expect = 4.2
Identities = 21/67 (31%), Positives = 25/67 (37%), Gaps = 2/67 (2%)
Query: 262 GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDT 321
G P +WFKD EL I G S L V G+Y C N +G D+
Sbjct: 5355 GTPPFKIKWFKDDVELVSGPKCFI--GLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDS 5412
Query: 322 VRGRLYV 328
L V
Sbjct: 5413 CTTMLLV 5419
Score = 31.2 bits (69), Expect = 4.2
Identities = 19/69 (27%), Positives = 27/69 (39%), Gaps = 2/69 (2%)
Query: 262 GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDT 321
G P S WFK EL + + + L+ V +GEY C N GK +
Sbjct: 7800 GTPPFSVSWFKGSSELVPGDRCNVSLEDSV--AELELFDVDTSQSGEYTCIVSNEAGKAS 7857
Query: 322 VRGRLYVNS 330
LY+ +
Sbjct: 7858 CTTHLYIKA 7866
Score = 31.2 bits (69), Expect = 4.2
Identities = 22/73 (30%), Positives = 31/73 (42%), Gaps = 2/73 (2%)
Query: 246 TGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVED 305
T + G+ L + G P P W K GK++ S +I + +S L +D
Sbjct: 20389 TIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQIT--STPTSSMLTIKYATRKD 20446
Query: 306 AGEYVCEAENILG 318
AGEY A N G
Sbjct: 20447 AGEYTITATNPFG 20459
Score = 31.2 bits (69), Expect = 4.2
Identities = 16/58 (27%), Positives = 30/58 (51%), Gaps = 2/58 (3%)
Query: 262 GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGK 319
G P+P+ W K + L +++ R+ + ++ L N+ D+G Y A NI+G+
Sbjct: 21091 GRPKPTVTWKKGDQILKQTQ--RVNFETTATSTILNINECVRSDSGPYPLTARNIVGE 21146
Score = 31.2 bits (69), Expect = 4.2
Identities = 17/61 (27%), Positives = 29/61 (47%), Gaps = 1/61 (1%)
Query: 262 GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDT 321
G P P W KDGKEL + R++ + + + L D G+Y+ + N+ G +
Sbjct: 24733 GKPIPDVVWSKDGKELEETA-ARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKS 24791
Query: 322 V 322
+
Sbjct: 24792 I 24792
Score = 30.8 bits (68), Expect = 5.5
Identities = 19/77 (24%), Positives = 37/77 (48%), Gaps = 4/77 (5%)
Query: 240 KKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFN 299
+ ++ T + G+ ++ C+ + P WF++G+ L R K K +L
Sbjct: 8749 RHLQDVTLKEGQTCTMTCQFSV--PNVKSEWFRNGRILKPQG--RHKTEVEHKVHKLTIA 8804
Query: 300 KVKVEDAGEYVCEAENI 316
V+ ED G+Y C+ E++
Sbjct: 8805 DVRAEDQGQYTCKYEDL 8821
Score = 30.8 bits (68), Expect = 5.5
Identities = 19/58 (32%), Positives = 25/58 (43%), Gaps = 2/58 (3%)
Query: 261 AGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILG 318
+G P+P WFKD E + D R L+ K K D+G+Y EN G
Sbjct: 16843 SGKPKPKVSWFKD--EADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTG 16898
Score = 30.8 bits (68), Expect = 5.5
Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 3/61 (4%)
Query: 220 NLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQ--SLKCEAA-AGNPQPSYRWFKDGKE 276
N + VG I C D P + T V + S+K A +G P P+ W+KD KE
Sbjct: 26853 NPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKE 26912
Query: 277 L 277
L
Sbjct: 26913 L 26913
Score = 30.8 bits (68), Expect = 5.5
Identities = 23/107 (21%), Positives = 39/107 (36%), Gaps = 2/107 (1%)
Query: 225 VGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIR 284
V K+ P ++ G+ G C+ + W+ ++L S
Sbjct: 31557 VAKVKVASIEIGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYE 31616
Query: 285 IKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSV 331
I Y +G + L + D G Y C+ N G+D+ L+V V
Sbjct: 31617 ITYEDGV--AILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGV 31661
Score = 30.4 bits (67), Expect = 7.2
Identities = 18/59 (30%), Positives = 28/59 (47%), Gaps = 2/59 (3%)
Query: 262 GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKD 320
G P S W KD +++S R K++ L+ + +ED +Y C EN G+D
Sbjct: 6952 GTPPISVSWIKDEYLISQSE--RCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQD 7008
Score = 30.4 bits (67), Expect = 7.2
Identities = 16/57 (28%), Positives = 27/57 (47%), Gaps = 2/57 (3%)
Query: 262 GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILG 318
G P P+ W + KE+ S IK K + + +++ D G+Y+ A N+ G
Sbjct: 23651 GKPLPTIEWLRGDKEIEESARCEIK-NTDFKALLIVKDAIRI-DGGQYILRASNVAG 23705
Score = 30.0 bits (66), Expect = 9.4
Identities = 28/112 (25%), Positives = 42/112 (37%), Gaps = 22/112 (19%)
Query: 200 PTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEA 259
P E P ++ PL KE+ I+ T+ VG +C
Sbjct: 11101 PDEAPFTYQLKAVPL-----KFVKEIKDIILTESEF-------------VGSSAIFECLV 11142
Query: 260 AAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVC 311
+ + W KDG + S R +G K+ +L V++ DAGEY C
Sbjct: 11143 SPSTAITT--WMKDGSNIRESPKHRF-IADG-KDRKLHIIDVQLSDAGEYTC 11190
Score = 30.0 bits (66), Expect = 9.4
Identities = 21/63 (33%), Positives = 29/63 (46%), Gaps = 4/63 (6%)
Query: 261 AGNPQPSYRWFKDGKEL-NRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGK 319
AG P P W KDG E+ R+R I N ++ L D G+YV +N+ G
Sbjct: 25814 AGRPLPVISWAKDGIEIEERARTEIISTDN---HTLLTVKDCIRRDTGQYVLTLKNVAGT 25870
Query: 320 DTV 322
+V
Sbjct: 25871 RSV 25873
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,445,548
Number of Sequences: 37866
Number of extensions: 2403808
Number of successful extensions: 39218
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 650
Number of HSP's successfully gapped in prelim test: 1294
Number of HSP's that attempted gapping in prelim test: 21741
Number of HSP's gapped (non-prelim): 13056
length of query: 844
length of database: 18,247,518
effective HSP length: 111
effective length of query: 733
effective length of database: 14,044,392
effective search space: 10294539336
effective search space used: 10294539336
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.