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Search of human proteins with 7661946
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7661946 IKK-related kinase epsilon [Homo sapiens]
(716 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7661946 IKK-related kinase epsilon [Homo sapiens] 1419 0.0
gi|7019547 TANK-binding kinase 1 [Homo sapiens] 660 0.0
gi|41352712 inhibitor of nuclear factor kappa B kinase beta subu... 148 2e-35
gi|62241001 conserved helix-loop-helix ubiquitous kinase [Homo s... 133 5e-31
gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 111 2e-24
gi|217330559 unc-51-like kinase 2 [Homo sapiens] 111 3e-24
gi|217330557 unc-51-like kinase 2 [Homo sapiens] 111 3e-24
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 107 4e-23
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 105 1e-22
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 105 1e-22
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 102 9e-22
gi|4557511 death-associated protein kinase 3 [Homo sapiens] 101 3e-21
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 100 4e-21
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 100 4e-21
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 100 4e-21
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 100 4e-21
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 100 5e-21
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 100 5e-21
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 100 5e-21
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 100 5e-21
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 100 5e-21
gi|14670383 death-associated kinase 2 [Homo sapiens] 100 5e-21
gi|115529463 protein kinase D1 [Homo sapiens] 100 8e-21
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 99 1e-20
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 99 1e-20
gi|5031689 protein kinase D3 [Homo sapiens] 99 1e-20
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 99 1e-20
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 99 1e-20
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 99 1e-20
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 99 2e-20
>gi|7661946 IKK-related kinase epsilon [Homo sapiens]
Length = 716
Score = 1419 bits (3674), Expect = 0.0
Identities = 716/716 (100%), Positives = 716/716 (100%)
Query: 1 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR 60
MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
Sbjct: 1 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR 60
Query: 61 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV 120
KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
Sbjct: 61 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV 120
Query: 121 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL 180
AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
Sbjct: 121 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL 180
Query: 181 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE 240
HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
Sbjct: 181 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE 240
Query: 241 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA 300
KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
Sbjct: 241 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA 300
Query: 301 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV 360
ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
Sbjct: 301 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV 360
Query: 361 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG 420
LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
Sbjct: 361 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG 420
Query: 421 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV 480
AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV
Sbjct: 421 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV 480
Query: 481 AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI 540
AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI
Sbjct: 481 AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI 540
Query: 541 QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY 600
QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY
Sbjct: 541 QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY 600
Query: 601 QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG 660
QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG
Sbjct: 601 QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG 660
Query: 661 AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV 716
AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV
Sbjct: 661 AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV 716
>gi|7019547 TANK-binding kinase 1 [Homo sapiens]
Length = 729
Score = 660 bits (1702), Expect = 0.0
Identities = 351/717 (48%), Positives = 468/717 (65%), Gaps = 15/717 (2%)
Query: 1 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR 60
MQST+N+LW D+LGQGATA+V++ R+KK+G+L A+KVFN S+LRP +VQ+REFEVL+
Sbjct: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60
Query: 61 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV 120
KLNH+NIVKLFA+EE +R KVL+ME+C GSL +VLE P NA+GLPE EFL+VLR VV
Sbjct: 61 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120
Query: 121 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL 180
GMNHLRENGIVHRDIKPGNIMR++GE+GQS+YKLTDFGAAREL+DDE+FVS+YGTEEYL
Sbjct: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 180
Query: 181 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE 240
HPDMYERAVLRK QK +G TVDLWSIGVT YHAATGSLPF PF GPRRNKE+MY+I T
Sbjct: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240
Query: 241 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA 300
KP+GAI+G Q+ ENGP++WS +P++C LS GLQ L P+LANILE +Q KCWGFDQFFA
Sbjct: 241 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA 300
Query: 301 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV 360
ETSDIL R+V+HVFSL Q H IYIH++NT IF E V+KQT + +QE ++EG V
Sbjct: 301 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV 360
Query: 361 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG 420
LEP AQH TT +P+ + S + + +PK P+ DL D + AK + G
Sbjct: 361 LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG 420
Query: 421 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGT------ 474
A R+A LL QELM +G+ W++E+++ T+ ++ L +
Sbjct: 421 VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK 480
Query: 475 --ERFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLS---SLNRELVK 529
E+ + E EL +++ ++L L+ ++ + LS SL
Sbjct: 481 VYEKLMKI--NLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAH 538
Query: 530 SRDQVHEDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLL 589
+DR+++++Q L+ M IY QFKK + L YNEEQIHK DK + A + +
Sbjct: 539 QEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAM 598
Query: 590 QVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEEL 649
F +ECV+KY+A L + +R + R L + E QE ++L E L
Sbjct: 599 THFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETL 658
Query: 650 SHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIER 706
++ + G + + PI P S T ++ L M++L E M+ + +L +NN I+ER
Sbjct: 659 PQKMF-TASSGIKHTMTPIYP-SSNTLVEMTLGMKKLKEEMEGVVKELAENNHILER 713
>gi|41352712 inhibitor of nuclear factor kappa B kinase beta subunit
[Homo sapiens]
Length = 756
Score = 148 bits (373), Expect = 2e-35
Identities = 104/372 (27%), Positives = 169/372 (45%), Gaps = 23/372 (6%)
Query: 9 WHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQNIV 68
W + LG G +V + N+++GE +A+K R RE E +++R+L H N+V
Sbjct: 15 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 74
Query: 69 KLFAVEE----TGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMN 124
V E + +L MEYC G L L EN GL E L +L + + +
Sbjct: 75 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 134
Query: 125 HLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDM 184
+L EN I+HRD+KP NI+ GE+ + I+K+ D G A+ELD S GT +YL P++
Sbjct: 135 YLHENRIIHRDLKPENIVLQQGEQ-RLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 193
Query: 185 YERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAG 244
E Q+ + VTVD WS G + TG PF+P P + + + +
Sbjct: 194 LE--------QQKYTVTVDYWSFGTLAFECITGFRPFLPNWQP-----VQWHSKVRQKSE 240
Query: 245 AIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAK-----CWGFDQFF 299
NG +++S +LP L+ L +L L +L + +G + F
Sbjct: 241 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF 300
Query: 300 AETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLC 359
DIL +VH+ ++ +H + ++ + + + T + QE L E L
Sbjct: 301 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA 360
Query: 360 VLEPSVSAQHIA 371
++ + Q I+
Sbjct: 361 LIPDKPATQCIS 372
>gi|62241001 conserved helix-loop-helix ubiquitous kinase [Homo
sapiens]
Length = 745
Score = 133 bits (335), Expect = 5e-31
Identities = 100/363 (27%), Positives = 165/363 (45%), Gaps = 36/363 (9%)
Query: 9 WHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQNIV 68
W + LG G +V ++++ +A+K + RE E ++++KLNH N+V
Sbjct: 15 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV 74
Query: 69 KLFAVEETGG---SRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNH 125
K V E +L MEYCS G L +L PEN GL E + L +L + +G+ +
Sbjct: 75 KACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRY 134
Query: 126 LRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMY 185
L EN I+HRD+KP NI+ L G+ I+K+ D G A+++D S GT +YL P+++
Sbjct: 135 LHENKIIHRDLKPENIV-LQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELF 193
Query: 186 ERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGA 245
E K + TVD WS G ++ G PF+ P E +I + P
Sbjct: 194 E--------NKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHE---KIKKKDPKCI 242
Query: 246 IAGAQRRENGPLEWSYTLP---ITCQLSLGLQSQLVPILAN----------ILEVEQAKC 292
A + +G + +S LP C L + + ++ N L ++Q +C
Sbjct: 243 FACEEM--SGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRC 300
Query: 293 WGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEY 352
F IL +VH+ +++ A + + ++ Q + ++T + QE
Sbjct: 301 ------FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQEL 354
Query: 353 LFE 355
L E
Sbjct: 355 LSE 357
>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
Length = 1050
Score = 111 bits (278), Expect = 2e-24
Identities = 72/227 (31%), Positives = 114/227 (50%), Gaps = 21/227 (9%)
Query: 2 QSTANYLWHTDDLLGQGATASVYKARNKKSGEL-VAVKVFNTTSYLRPREVQVREFEVLR 60
++ + + DL+G GA A V+K R+++ +L VAVK N + + + + +E ++L+
Sbjct: 9 ETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILK 68
Query: 61 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV 120
+L H+NIV L+ +E S LVMEYC+ G L L + L ED + L+ +
Sbjct: 69 ELKHENIVALYDFQEMANS--VYLVMEYCNGGDLADYLHAMRT---LSEDTIRLFLQQIA 123
Query: 121 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSI------YKLTDFGAARELDDDEKFVSVY 174
M L GI+HRD+KP NI+ L G+ K+ DFG AR L + ++
Sbjct: 124 GAMRLLHSKGIIHRDLKPQNIL-LSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLC 182
Query: 175 GTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
G+ Y+ P++ + + DLWSIG +Y TG PF
Sbjct: 183 GSPMYMAPEVI--------MSQHYDGKADLWSIGTIVYQCLTGKAPF 221
>gi|217330559 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 111 bits (277), Expect = 3e-24
Identities = 71/227 (31%), Positives = 114/227 (50%), Gaps = 19/227 (8%)
Query: 1 MQSTANYLWHTDDLLGQGATASVYKARNKKSGEL-VAVKVFNTTSYLRPREVQVREFEVL 59
M+ ++ + DL+G GA A V++ R+++ + VA+K N + + + + +E ++L
Sbjct: 1 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL 60
Query: 60 RKLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCV 119
++L H+NIV L+ V+E S LVMEYC+ G L L++ L ED V L +
Sbjct: 61 KELQHENIVALYDVQELPNS--VFLVMEYCNGGDLADYLQAKGT---LSEDTIRVFLHQI 115
Query: 120 VAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSI-----YKLTDFGAARELDDDEKFVSVY 174
A M L GI+HRD+KP NI+ +S K+ DFG AR L + ++
Sbjct: 116 AAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLC 175
Query: 175 GTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
G+ Y+ P++ + + DLWSIG +Y G PF
Sbjct: 176 GSPMYMAPEVI--------MSQHYDAKADLWSIGTVIYQCLVGKPPF 214
>gi|217330557 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 111 bits (277), Expect = 3e-24
Identities = 71/227 (31%), Positives = 114/227 (50%), Gaps = 19/227 (8%)
Query: 1 MQSTANYLWHTDDLLGQGATASVYKARNKKSGEL-VAVKVFNTTSYLRPREVQVREFEVL 59
M+ ++ + DL+G GA A V++ R+++ + VA+K N + + + + +E ++L
Sbjct: 1 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL 60
Query: 60 RKLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCV 119
++L H+NIV L+ V+E S LVMEYC+ G L L++ L ED V L +
Sbjct: 61 KELQHENIVALYDVQELPNS--VFLVMEYCNGGDLADYLQAKGT---LSEDTIRVFLHQI 115
Query: 120 VAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSI-----YKLTDFGAARELDDDEKFVSVY 174
A M L GI+HRD+KP NI+ +S K+ DFG AR L + ++
Sbjct: 116 AAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLC 175
Query: 175 GTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
G+ Y+ P++ + + DLWSIG +Y G PF
Sbjct: 176 GSPMYMAPEVI--------MSQHYDAKADLWSIGTVIYQCLVGKPPF 214
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 107 bits (267), Expect = 4e-23
Identities = 72/209 (34%), Positives = 111/209 (53%), Gaps = 19/209 (9%)
Query: 15 LGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQ--VREFEVLRKLNHQNIVKLFA 72
+G+G A V AR+ +G VA+K+ + T L P +Q RE +++ LNH NIVKLF
Sbjct: 65 IGKGNFAKVKLARHILTGREVAIKIIDKTQ-LNPSSLQKLFREVRIMKGLNHPNIVKLFE 123
Query: 73 VEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIV 132
V ET + LVMEY S+G + L S + E E R +V+ +++ + IV
Sbjct: 124 VIET--EKTLYLVMEYASAGEVFDYLVSHGR---MKEKEARAKFRQIVSAVHYCHQKNIV 178
Query: 133 HRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRK 192
HRD+K N++ + ++ K+ DFG + E K + G+ Y P++++
Sbjct: 179 HRDLKAENLLL----DAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQG----- 229
Query: 193 PQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
+K G VD+WS+GV LY +GSLPF
Sbjct: 230 --KKYDGPEVDIWSLGVILYTLVSGSLPF 256
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 105 bits (263), Expect = 1e-22
Identities = 73/216 (33%), Positives = 113/216 (52%), Gaps = 22/216 (10%)
Query: 9 WHTDDLLGQGATASVYKARNKKSGELVAVKVFNTT--SYLRPREVQVREFEVLRKLNHQN 66
+H +++G+G+ VYK R K S ++VA+K S R +Q RE E++R L H N
Sbjct: 4 YHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQ-REIEIMRGLRHPN 62
Query: 67 IVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHL 126
IV + ET ++ V+V +Y + G L +LE LPED+ + +V+ + +L
Sbjct: 63 IVHMLDSFET--DKEVVVVTDY-AEGELFQILEDDGK---LPEDQVQAIAAQLVSALYYL 116
Query: 127 RENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEK-FVSVYGTEEYLHPDMY 185
+ I+HRD+KP NI+ G KL DFG AR + + S+ GT Y+ P++
Sbjct: 117 HSHRILHRDMKPQNILLAKG----GGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELV 172
Query: 186 ERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
E ++ + T DLWS+G LY A G+ PF
Sbjct: 173 E--------ERPYDHTADLWSVGCILYELAVGTPPF 200
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 105 bits (262), Expect = 1e-22
Identities = 73/209 (34%), Positives = 108/209 (51%), Gaps = 19/209 (9%)
Query: 15 LGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQ--VREFEVLRKLNHQNIVKLFA 72
+G+G A V AR+ +G VAVK+ + T L P +Q RE +++ LNH NIVKLF
Sbjct: 66 IGKGNFAKVKLARHVLTGREVAVKIIDKTQ-LNPTSLQKLFREVRIMKILNHPNIVKLFE 124
Query: 73 VEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIV 132
V ET + LVMEY S G + L + + E E R +V+ + + + IV
Sbjct: 125 VIET--EKTLYLVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVSAVQYCHQKYIV 179
Query: 133 HRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRK 192
HRD+K N++ +G K+ DFG + E K + G+ Y P++++
Sbjct: 180 HRDLKAENLLL----DGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQG----- 230
Query: 193 PQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
+K G VD+WS+GV LY +GSLPF
Sbjct: 231 --KKYDGPEVDVWSLGVILYTLVSGSLPF 257
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 102 bits (255), Expect = 9e-22
Identities = 65/230 (28%), Positives = 120/230 (52%), Gaps = 20/230 (8%)
Query: 9 WHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQNIV 68
+ T ++G G A V + R++++ + A+K+ + + ++ E +++ L+H NIV
Sbjct: 356 YETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLSHPNIV 415
Query: 69 KLFAVEETGGSRQKVLVMEYCSSGSLL-SVLESPENAFGLPEDEFLVVLRCVVAGMNHLR 127
KL V ET + L++EY G L +++ES + PE + +++ + + H+
Sbjct: 416 KLHEVYET--DMEIYLILEYVQGGDLFDAIIESVK----FPEPDAALMIMDLCKALVHMH 469
Query: 128 ENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYER 187
+ IVHRD+KP N++ E+ + KL DFG A+ + +V GT Y+ P++
Sbjct: 470 DKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHV--VRPIFTVCGTPTYVAPEIL-- 525
Query: 188 AVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRI 237
+K +G+ VD+W+ GV LY G F PF P R+++ ++ I
Sbjct: 526 ------SEKGYGLEVDMWAAGVILYILLCG---FPPFRSPERDQDELFNI 566
>gi|4557511 death-associated protein kinase 3 [Homo sapiens]
Length = 454
Score = 101 bits (251), Expect = 3e-21
Identities = 70/213 (32%), Positives = 105/213 (49%), Gaps = 18/213 (8%)
Query: 15 LGQGATASVYKARNKKSGELVAVKVFNT---TSYLR--PREVQVREFEVLRKLNHQNIVK 69
LG G A V K R K +G+ A K +S R RE RE +LR++ H NI+
Sbjct: 19 LGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIIT 78
Query: 70 LFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLREN 129
L + E VL++E S G L L E+ L EDE L+ ++ G+++L
Sbjct: 79 LHDIFEN--KTDVVLILELVSGGELFDFLAEKES---LTEDEATQFLKQILDGVHYLHSK 133
Query: 130 GIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAV 189
I H D+KP NIM L KL DFG A +++ +F +++GT E++ P++
Sbjct: 134 RIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIV---- 189
Query: 190 LRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFI 222
+ G+ D+WSIGV Y +G+ PF+
Sbjct: 190 ----NYEPLGLEADMWSIGVITYILLSGASPFL 218
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 100 bits (250), Expect = 4e-21
Identities = 70/209 (33%), Positives = 107/209 (51%), Gaps = 19/209 (9%)
Query: 15 LGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQ--VREFEVLRKLNHQNIVKLFA 72
+G+G A V AR+ +G VA+K+ + T L P +Q RE +++ LNH NIVKLF
Sbjct: 62 IGKGNFAKVKLARHILTGREVAIKIIDKTQ-LNPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 73 VEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIV 132
V ET + L+MEY S G + L + + E E R +V+ + + + IV
Sbjct: 121 VIET--EKTLYLIMEYASGGEVFDYLVAHGR---MKEKEARSKFRQIVSAVQYCHQKRIV 175
Query: 133 HRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRK 192
HRD+K N++ + K+ DFG + E K + G+ Y P++++
Sbjct: 176 HRDLKAENLLL----DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQG----- 226
Query: 193 PQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
+K G VD+WS+GV LY +GSLPF
Sbjct: 227 --KKYDGPEVDVWSLGVILYTLVSGSLPF 253
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 100 bits (250), Expect = 4e-21
Identities = 70/209 (33%), Positives = 107/209 (51%), Gaps = 19/209 (9%)
Query: 15 LGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQ--VREFEVLRKLNHQNIVKLFA 72
+G+G A V AR+ +G VA+K+ + T L P +Q RE +++ LNH NIVKLF
Sbjct: 62 IGKGNFAKVKLARHILTGREVAIKIIDKTQ-LNPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 73 VEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIV 132
V ET + L+MEY S G + L + + E E R +V+ + + + IV
Sbjct: 121 VIET--EKTLYLIMEYASGGEVFDYLVAHGR---MKEKEARSKFRQIVSAVQYCHQKRIV 175
Query: 133 HRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRK 192
HRD+K N++ + K+ DFG + E K + G+ Y P++++
Sbjct: 176 HRDLKAENLLL----DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQG----- 226
Query: 193 PQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
+K G VD+WS+GV LY +GSLPF
Sbjct: 227 --KKYDGPEVDVWSLGVILYTLVSGSLPF 253
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 100 bits (250), Expect = 4e-21
Identities = 70/209 (33%), Positives = 107/209 (51%), Gaps = 19/209 (9%)
Query: 15 LGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQ--VREFEVLRKLNHQNIVKLFA 72
+G+G A V AR+ +G VA+K+ + T L P +Q RE +++ LNH NIVKLF
Sbjct: 62 IGKGNFAKVKLARHILTGREVAIKIIDKTQ-LNPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 73 VEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIV 132
V ET + L+MEY S G + L + + E E R +V+ + + + IV
Sbjct: 121 VIET--EKTLYLIMEYASGGEVFDYLVAHGR---MKEKEARSKFRQIVSAVQYCHQKRIV 175
Query: 133 HRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRK 192
HRD+K N++ + K+ DFG + E K + G+ Y P++++
Sbjct: 176 HRDLKAENLLL----DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQG----- 226
Query: 193 PQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
+K G VD+WS+GV LY +GSLPF
Sbjct: 227 --KKYDGPEVDVWSLGVILYTLVSGSLPF 253
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 100 bits (250), Expect = 4e-21
Identities = 70/209 (33%), Positives = 107/209 (51%), Gaps = 19/209 (9%)
Query: 15 LGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQ--VREFEVLRKLNHQNIVKLFA 72
+G+G A V AR+ +G VA+K+ + T L P +Q RE +++ LNH NIVKLF
Sbjct: 62 IGKGNFAKVKLARHILTGREVAIKIIDKTQ-LNPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 73 VEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIV 132
V ET + L+MEY S G + L + + E E R +V+ + + + IV
Sbjct: 121 VIET--EKTLYLIMEYASGGEVFDYLVAHGR---MKEKEARSKFRQIVSAVQYCHQKRIV 175
Query: 133 HRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRK 192
HRD+K N++ + K+ DFG + E K + G+ Y P++++
Sbjct: 176 HRDLKAENLLL----DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQG----- 226
Query: 193 PQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
+K G VD+WS+GV LY +GSLPF
Sbjct: 227 --KKYDGPEVDVWSLGVILYTLVSGSLPF 253
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 100 bits (249), Expect = 5e-21
Identities = 71/209 (33%), Positives = 107/209 (51%), Gaps = 19/209 (9%)
Query: 15 LGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQ--VREFEVLRKLNHQNIVKLFA 72
+G+G A V AR+ +G+ VAVK+ + T L +Q RE +++ LNH NIVKLF
Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQ-LNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
Query: 73 VEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIV 132
V ET + LVMEY S G + L + + E E R +V+ + + + IV
Sbjct: 118 VIET--EKTLYLVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVSAVQYCHQKFIV 172
Query: 133 HRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRK 192
HRD+K N++ + K+ DFG + E K + G+ Y P++++
Sbjct: 173 HRDLKAENLLL----DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG----- 223
Query: 193 PQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
+K G VD+WS+GV LY +GSLPF
Sbjct: 224 --KKYDGPEVDVWSLGVILYTLVSGSLPF 250
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 100 bits (249), Expect = 5e-21
Identities = 71/209 (33%), Positives = 107/209 (51%), Gaps = 19/209 (9%)
Query: 15 LGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQ--VREFEVLRKLNHQNIVKLFA 72
+G+G A V AR+ +G+ VAVK+ + T L +Q RE +++ LNH NIVKLF
Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQ-LNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
Query: 73 VEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIV 132
V ET + LVMEY S G + L + + E E R +V+ + + + IV
Sbjct: 118 VIET--EKTLYLVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVSAVQYCHQKFIV 172
Query: 133 HRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRK 192
HRD+K N++ + K+ DFG + E K + G+ Y P++++
Sbjct: 173 HRDLKAENLLL----DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG----- 223
Query: 193 PQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
+K G VD+WS+GV LY +GSLPF
Sbjct: 224 --KKYDGPEVDVWSLGVILYTLVSGSLPF 250
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 100 bits (249), Expect = 5e-21
Identities = 71/209 (33%), Positives = 107/209 (51%), Gaps = 19/209 (9%)
Query: 15 LGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQ--VREFEVLRKLNHQNIVKLFA 72
+G+G A V AR+ +G+ VAVK+ + T L +Q RE +++ LNH NIVKLF
Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQ-LNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
Query: 73 VEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIV 132
V ET + LVMEY S G + L + + E E R +V+ + + + IV
Sbjct: 118 VIET--EKTLYLVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVSAVQYCHQKFIV 172
Query: 133 HRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRK 192
HRD+K N++ + K+ DFG + E K + G+ Y P++++
Sbjct: 173 HRDLKAENLLL----DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG----- 223
Query: 193 PQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
+K G VD+WS+GV LY +GSLPF
Sbjct: 224 --KKYDGPEVDVWSLGVILYTLVSGSLPF 250
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 100 bits (249), Expect = 5e-21
Identities = 71/209 (33%), Positives = 107/209 (51%), Gaps = 19/209 (9%)
Query: 15 LGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQ--VREFEVLRKLNHQNIVKLFA 72
+G+G A V AR+ +G+ VAVK+ + T L +Q RE +++ LNH NIVKLF
Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQ-LNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
Query: 73 VEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIV 132
V ET + LVMEY S G + L + + E E R +V+ + + + IV
Sbjct: 118 VIET--EKTLYLVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVSAVQYCHQKFIV 172
Query: 133 HRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRK 192
HRD+K N++ + K+ DFG + E K + G+ Y P++++
Sbjct: 173 HRDLKAENLLL----DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG----- 223
Query: 193 PQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
+K G VD+WS+GV LY +GSLPF
Sbjct: 224 --KKYDGPEVDVWSLGVILYTLVSGSLPF 250
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 100 bits (249), Expect = 5e-21
Identities = 71/209 (33%), Positives = 107/209 (51%), Gaps = 19/209 (9%)
Query: 15 LGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQ--VREFEVLRKLNHQNIVKLFA 72
+G+G A V AR+ +G+ VAVK+ + T L +Q RE +++ LNH NIVKLF
Sbjct: 26 IGKGNFAKVKLARHILTGKEVAVKIIDKTQ-LNSSSLQKLFREVRIMKVLNHPNIVKLFE 84
Query: 73 VEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIV 132
V ET + LVMEY S G + L + + E E R +V+ + + + IV
Sbjct: 85 VIET--EKTLYLVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVSAVQYCHQKFIV 139
Query: 133 HRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRK 192
HRD+K N++ + K+ DFG + E K + G+ Y P++++
Sbjct: 140 HRDLKAENLLL----DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG----- 190
Query: 193 PQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
+K G VD+WS+GV LY +GSLPF
Sbjct: 191 --KKYDGPEVDVWSLGVILYTLVSGSLPF 217
>gi|14670383 death-associated kinase 2 [Homo sapiens]
Length = 370
Score = 100 bits (249), Expect = 5e-21
Identities = 69/213 (32%), Positives = 102/213 (47%), Gaps = 18/213 (8%)
Query: 15 LGQGATASVYKARNKKSGELVAVKVFNTTSYLRPR-----EVQVREFEVLRKLNHQNIVK 69
LG G A V K R K +G A K R E RE +LR++ H N++
Sbjct: 29 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 88
Query: 70 LFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLREN 129
L V E VL++E S G L L E+ L E+E ++ ++ G+N+L
Sbjct: 89 LHDVYEN--RTDVVLILELVSGGELFDFLAQKES---LSEEEATSFIKQILDGVNYLHTK 143
Query: 130 GIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAV 189
I H D+KP NIM L KL DFG A E++D +F +++GT E++ P++
Sbjct: 144 KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIV---- 199
Query: 190 LRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFI 222
+ G+ D+WSIGV Y +G+ PF+
Sbjct: 200 ----NYEPLGLEADMWSIGVITYILLSGASPFL 228
>gi|115529463 protein kinase D1 [Homo sapiens]
Length = 912
Score = 99.8 bits (247), Expect = 8e-21
Identities = 68/211 (32%), Positives = 112/211 (53%), Gaps = 14/211 (6%)
Query: 12 DDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVR-EFEVLRKLNHQNIVKL 70
D++LG G VY +++K+G VA+K+ + + +E Q+R E +L+ L+H +V L
Sbjct: 586 DEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNL 645
Query: 71 FAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENG 130
+ ET ++V V+ G +L ++ S E LPE ++ ++ + HL
Sbjct: 646 ECMFET---PERVFVVMEKLHGDMLEMILSSEKG-RLPEHITKFLITQILVALRHLHFKN 701
Query: 131 IVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVL 190
IVH D+KP N++ L + KL DFG AR + + SV GT YL P+ VL
Sbjct: 702 IVHCDLKPENVL-LASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPE-----VL 755
Query: 191 RKPQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
R K + ++D+WS+GV +Y + +G+ PF
Sbjct: 756 R---NKGYNRSLDMWSVGVIIYVSLSGTFPF 783
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 99.4 bits (246), Expect = 1e-20
Identities = 69/226 (30%), Positives = 109/226 (48%), Gaps = 18/226 (7%)
Query: 2 QSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFN---TTSYLR--PREVQVREF 56
Q + + T + LG G A V K R K +G A K T S R RE RE
Sbjct: 6 QENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREV 65
Query: 57 EVLRKLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVL 116
+L+++ H N++ L V E +L++E + G L L E+ L E+E L
Sbjct: 66 SILKEIQHPNVITLHEVYEN--KTDVILILELVAGGELFDFLAEKES---LTEEEATEFL 120
Query: 117 RCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGT 176
+ ++ G+ +L I H D+KP NIM L + K+ DFG A ++D +F +++GT
Sbjct: 121 KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT 180
Query: 177 EEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFI 222
E++ P++ + G+ D+WSIGV Y +G+ PF+
Sbjct: 181 PEFVAPEIV--------NYEPLGLEADMWSIGVITYILLSGASPFL 218
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 99.0 bits (245), Expect = 1e-20
Identities = 75/213 (35%), Positives = 112/213 (52%), Gaps = 22/213 (10%)
Query: 14 LLGQGATASVY---KARNKKSGELVAVKVFN-TTSYLRPREVQVREFEVLRKLNHQNIVK 69
+LGQG+ V+ K SG L A+KV T +R R E ++L +NH +VK
Sbjct: 76 VLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVK 135
Query: 70 LFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLREN 129
L +T G + L++++ G L + L S E F E++ L + G++HL
Sbjct: 136 LHYAFQTEG--KLYLILDFLRGGDLFTRL-SKEVMF--TEEDVKFYLAELALGLDHLHSL 190
Query: 130 GIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARE-LDDDEKFVSVYGTEEYLHPDMYERA 188
GI++RD+KP NI L+ EEG KLTDFG ++E +D ++K S GT EY+ P++ R
Sbjct: 191 GIIYRDLKPENI--LLDEEGH--IKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNR- 245
Query: 189 VLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
+ + D WS GV ++ TGSLPF
Sbjct: 246 -------QGHSHSADWWSYGVLMFEMLTGSLPF 271
Score = 68.9 bits (167), Expect = 2e-11
Identities = 60/231 (25%), Positives = 106/231 (45%), Gaps = 21/231 (9%)
Query: 13 DLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQNIVKLFA 72
+ +G G+ + + +K + AVKV + + E+++ +LR H NI+ L
Sbjct: 431 ETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEI----LLRYGQHPNIITLKD 486
Query: 73 VEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIV 132
V + G + LV E G LL + + E E VL + + +L G+V
Sbjct: 487 VYDDG--KHVYLVTELMRGGELLDKILRQKF---FSEREASFVLHTIGKTVEYLHSQGVV 541
Query: 133 HRDIKPGNIMRLVGEEGQSIYKLTDFGAAREL-DDDEKFVSVYGTEEYLHPDMYERAVLR 191
HRD+KP NI+ + ++ DFG A++L ++ ++ T ++ P++ +R
Sbjct: 542 HRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKR---- 597
Query: 192 KPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRN-KEIMYRITTEK 241
+ + D+WS+G+ LY G PF GP +EI+ RI + K
Sbjct: 598 ----QGYDEGCDIWSLGILLYTMLAGYTPFA--NGPSDTPEEILTRIGSGK 642
>gi|5031689 protein kinase D3 [Homo sapiens]
Length = 890
Score = 99.0 bits (245), Expect = 1e-20
Identities = 71/216 (32%), Positives = 114/216 (52%), Gaps = 14/216 (6%)
Query: 7 YLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVR-EFEVLRKLNHQ 65
Y D++LG G VY +++K+G VA+KV + + +E Q+R E +L+ L+H
Sbjct: 574 YQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHP 633
Query: 66 NIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNH 125
IV L + ET ++V V+ G +L ++ S E + LPE ++ ++ + +
Sbjct: 634 GIVNLECMFET---PERVFVVMEKLHGDMLEMILSSEKS-RLPERITKFMVTQILVALRN 689
Query: 126 LRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMY 185
L IVH D+KP N++ L E KL DFG AR + + SV GT YL P+
Sbjct: 690 LHFKNIVHCDLKPENVL-LASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPE-- 746
Query: 186 ERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
VLR K + ++D+WS+GV +Y + +G+ PF
Sbjct: 747 ---VLR---SKGYNRSLDMWSVGVIIYVSLSGTFPF 776
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 99.0 bits (245), Expect = 1e-20
Identities = 75/213 (35%), Positives = 112/213 (52%), Gaps = 22/213 (10%)
Query: 14 LLGQGATASVY---KARNKKSGELVAVKVFN-TTSYLRPREVQVREFEVLRKLNHQNIVK 69
+LGQG+ V+ K SG L A+KV T +R R E ++L +NH +VK
Sbjct: 67 VLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVK 126
Query: 70 LFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLREN 129
L +T G + L++++ G L + L S E F E++ L + G++HL
Sbjct: 127 LHYAFQTEG--KLYLILDFLRGGDLFTRL-SKEVMF--TEEDVKFYLAELALGLDHLHSL 181
Query: 130 GIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARE-LDDDEKFVSVYGTEEYLHPDMYERA 188
GI++RD+KP NI L+ EEG KLTDFG ++E +D ++K S GT EY+ P++ R
Sbjct: 182 GIIYRDLKPENI--LLDEEGH--IKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNR- 236
Query: 189 VLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
+ + D WS GV ++ TGSLPF
Sbjct: 237 -------QGHSHSADWWSYGVLMFEMLTGSLPF 262
Score = 68.9 bits (167), Expect = 2e-11
Identities = 60/231 (25%), Positives = 106/231 (45%), Gaps = 21/231 (9%)
Query: 13 DLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQNIVKLFA 72
+ +G G+ + + +K + AVKV + + E+++ +LR H NI+ L
Sbjct: 422 ETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEI----LLRYGQHPNIITLKD 477
Query: 73 VEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIV 132
V + G + LV E G LL + + E E VL + + +L G+V
Sbjct: 478 VYDDG--KHVYLVTELMRGGELLDKILRQKF---FSEREASFVLHTIGKTVEYLHSQGVV 532
Query: 133 HRDIKPGNIMRLVGEEGQSIYKLTDFGAAREL-DDDEKFVSVYGTEEYLHPDMYERAVLR 191
HRD+KP NI+ + ++ DFG A++L ++ ++ T ++ P++ +R
Sbjct: 533 HRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKR---- 588
Query: 192 KPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRN-KEIMYRITTEK 241
+ + D+WS+G+ LY G PF GP +EI+ RI + K
Sbjct: 589 ----QGYDEGCDIWSLGILLYTMLAGYTPFA--NGPSDTPEEILTRIGSGK 633
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 99.0 bits (245), Expect = 1e-20
Identities = 74/213 (34%), Positives = 114/213 (53%), Gaps = 22/213 (10%)
Query: 14 LLGQGATASVYKARNKK---SGELVAVKVFN-TTSYLRPREVQVREFEVLRKLNHQNIVK 69
+LGQG+ V+ R K +G+L A+KV T +R R E ++L ++NH IVK
Sbjct: 72 VLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVK 131
Query: 70 LFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLREN 129
L +T G + L++++ G L + L S E F E++ L + ++HL
Sbjct: 132 LHYAFQTEG--KLYLILDFLRGGDLFTRL-SKEVMF--TEEDVKFYLAELALALDHLHSL 186
Query: 130 GIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARE-LDDDEKFVSVYGTEEYLHPDMYERA 188
GI++RD+KP NI L+ EEG K+TDFG ++E +D D++ S GT EY+ P++ R
Sbjct: 187 GIIYRDLKPENI--LLDEEGH--IKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNR- 241
Query: 189 VLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
+ + D WS GV ++ TGSLPF
Sbjct: 242 -------RGHTQSADWWSFGVLMFEMLTGSLPF 267
Score = 67.8 bits (164), Expect = 3e-11
Identities = 61/230 (26%), Positives = 104/230 (45%), Gaps = 19/230 (8%)
Query: 15 LGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQNIVKLFAVE 74
+G G+ + + +K + AVK+ + + E+++ +LR H NI+ L V
Sbjct: 429 IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEI----LLRYGQHPNIITLKDVY 484
Query: 75 ETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIVHR 134
+ G + LVME G LL + E E VL + M++L G+VHR
Sbjct: 485 DDG--KFVYLVMELMRGGELLDRILRQRY---FSEREASDVLCTITKTMDYLHSQGVVHR 539
Query: 135 DIKPGNIMRLVGEEGQSIYKLTDFGAAREL-DDDEKFVSVYGTEEYLHPDMYERAVLRKP 193
D+KP NI+ ++ DFG A++L + ++ T ++ P++ +R
Sbjct: 540 DLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKR------ 593
Query: 194 QQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPA 243
+ + D+WS+G+ LY G PF G +EI+ RI + K A
Sbjct: 594 --QGYDAACDIWSLGILLYTMLAGFTPFAN-GPDDTPEEILARIGSGKYA 640
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 99.0 bits (245), Expect = 1e-20
Identities = 74/213 (34%), Positives = 114/213 (53%), Gaps = 22/213 (10%)
Query: 14 LLGQGATASVYKARNKK---SGELVAVKVFN-TTSYLRPREVQVREFEVLRKLNHQNIVK 69
+LGQG+ V+ R K +G+L A+KV T +R R E ++L ++NH IVK
Sbjct: 64 VLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVK 123
Query: 70 LFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLREN 129
L +T G + L++++ G L + L S E F E++ L + ++HL
Sbjct: 124 LHYAFQTEG--KLYLILDFLRGGDLFTRL-SKEVMF--TEEDVKFYLAELALALDHLHSL 178
Query: 130 GIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARE-LDDDEKFVSVYGTEEYLHPDMYERA 188
GI++RD+KP NI L+ EEG K+TDFG ++E +D D++ S GT EY+ P++ R
Sbjct: 179 GIIYRDLKPENI--LLDEEGH--IKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNR- 233
Query: 189 VLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPF 221
+ + D WS GV ++ TGSLPF
Sbjct: 234 -------RGHTQSADWWSFGVLMFEMLTGSLPF 259
Score = 67.8 bits (164), Expect = 3e-11
Identities = 61/230 (26%), Positives = 104/230 (45%), Gaps = 19/230 (8%)
Query: 15 LGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQNIVKLFAVE 74
+G G+ + + +K + AVK+ + + E+++ +LR H NI+ L V
Sbjct: 421 IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEI----LLRYGQHPNIITLKDVY 476
Query: 75 ETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIVHR 134
+ G + LVME G LL + E E VL + M++L G+VHR
Sbjct: 477 DDG--KFVYLVMELMRGGELLDRILRQRY---FSEREASDVLCTITKTMDYLHSQGVVHR 531
Query: 135 DIKPGNIMRLVGEEGQSIYKLTDFGAAREL-DDDEKFVSVYGTEEYLHPDMYERAVLRKP 193
D+KP NI+ ++ DFG A++L + ++ T ++ P++ +R
Sbjct: 532 DLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKR------ 585
Query: 194 QQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPA 243
+ + D+WS+G+ LY G PF G +EI+ RI + K A
Sbjct: 586 --QGYDAACDIWSLGILLYTMLAGFTPFAN-GPDDTPEEILARIGSGKYA 632
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 98.6 bits (244), Expect = 2e-20
Identities = 80/283 (28%), Positives = 130/283 (45%), Gaps = 27/283 (9%)
Query: 6 NYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQ 65
N +W LG GA VYKA+NK++G L A KV T S E + E E+L +H
Sbjct: 33 NEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSE-EELEDYIVEIEILATCDHP 91
Query: 66 NIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNH 125
IVKL G + +++E+C G++ +++ + GL E + VV R ++ +N
Sbjct: 92 YIVKLLGAYYHDG--KLWIMIEFCPGGAVDAIMLELDR--GLTEPQIQVVCRQMLEALNF 147
Query: 126 LRENGIVHRDIKPGNI-MRLVGEEGQSIYKLTDFG-AARELDDDEKFVSVYGTEEYLHPD 183
L I+HRD+K GN+ M L G+ +L DFG +A+ L +K S GT ++ P+
Sbjct: 148 LHSKRIIHRDLKAGNVLMTLEGD-----IRLADFGVSAKNLKTLQKRDSFIGTPYWMAPE 202
Query: 184 MYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPA 243
+ + + + D+WS+G+TL A P R ++ +I P
Sbjct: 203 V---VMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMR----VLLKIAKSDPP 255
Query: 244 GAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILE 286
+ P +WS +++L + P A +LE
Sbjct: 256 TLLT--------PSKWSVEFRDFLKIALDKNPETRPSAAQLLE 290
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,285,513
Number of Sequences: 37866
Number of extensions: 1172497
Number of successful extensions: 6237
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 303
Number of HSP's successfully gapped in prelim test: 507
Number of HSP's that attempted gapping in prelim test: 4411
Number of HSP's gapped (non-prelim): 1064
length of query: 716
length of database: 18,247,518
effective HSP length: 109
effective length of query: 607
effective length of database: 14,120,124
effective search space: 8570915268
effective search space used: 8570915268
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.