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Search of human proteins with 7657641
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7657641 TDP-glucose 4,6-dehydratase [Homo sapiens]
(350 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7657641 TDP-glucose 4,6-dehydratase [Homo sapiens] 728 0.0
gi|42516563 UDP-glucuronate decarboxylase 1 [Homo sapiens] 108 7e-24
gi|56118217 UDP-galactose-4-epimerase [Homo sapiens] 85 1e-16
gi|56237023 UDP-galactose-4-epimerase [Homo sapiens] 85 1e-16
gi|189083684 UDP-galactose-4-epimerase [Homo sapiens] 85 1e-16
gi|4504031 GDP-mannose 4,6-dehydratase [Homo sapiens] 70 3e-12
gi|4504507 3 beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 63 3e-10
gi|116268111 short chain dehydrogenase/reductase family 42E, mem... 61 2e-09
gi|4504509 3 beta-hydroxysteroid dehydrogenase 2 [Homo sapiens] 59 5e-09
gi|4507709 tissue specific transplantation antigen P35B [Homo sa... 58 1e-08
gi|193211614 NAD(P) dependent steroid dehydrogenase-like [Homo s... 50 2e-06
gi|8393516 NAD(P) dependent steroid dehydrogenase-like [Homo sap... 50 2e-06
gi|239745448 PREDICTED: hypothetical protein XP_002343493 [Homo ... 48 1e-05
gi|19923621 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and s... 48 1e-05
gi|239756515 PREDICTED: similar to Putative 3-beta-HSD family pr... 48 1e-05
gi|239751020 PREDICTED: hypothetical protein XP_002347673 [Homo ... 48 1e-05
gi|218563686 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and ... 48 1e-05
gi|218563684 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and ... 48 1e-05
gi|33519455 methionine adenosyltransferase II, beta isoform 2 [H... 33 0.38
gi|11034825 methionine adenosyltransferase II, beta isoform 1 [H... 33 0.38
gi|7656940 chromosome 1 open reading frame 9 protein isoform 1 [... 32 1.1
gi|31542658 fatty acyl CoA reductase 2 [Homo sapiens] 31 1.4
gi|253314447 RAD52 motif 1 isoform 5 [Homo sapiens] 29 5.5
gi|253314445 RAD52 motif 1 isoform 4 [Homo sapiens] 29 5.5
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens] 29 5.5
gi|4505363 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5,... 28 9.4
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 28 9.4
>gi|7657641 TDP-glucose 4,6-dehydratase [Homo sapiens]
Length = 350
Score = 728 bits (1878), Expect = 0.0
Identities = 350/350 (100%), Positives = 350/350 (100%)
Query: 1 MSAACWEEPWGLPGGFAKRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKN 60
MSAACWEEPWGLPGGFAKRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKN
Sbjct: 1 MSAACWEEPWGLPGGFAKRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKN 60
Query: 61 LETISNKQNYKFIQGDICDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVY 120
LETISNKQNYKFIQGDICDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVY
Sbjct: 61 LETISNKQNYKFIQGDICDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVY 120
Query: 121 GTHVLVSAAHEARVEKFIYVSTDEVYGGSLDKEFDESSPKQPTNPYASSKAAAECFVQSY 180
GTHVLVSAAHEARVEKFIYVSTDEVYGGSLDKEFDESSPKQPTNPYASSKAAAECFVQSY
Sbjct: 121 GTHVLVSAAHEARVEKFIYVSTDEVYGGSLDKEFDESSPKQPTNPYASSKAAAECFVQSY 180
Query: 181 WEQYKFPVVITRSSNVYGPHQYPEKVIPKFISLLQHNRKCCIHGSGLQTRNFLYATDVVE 240
WEQYKFPVVITRSSNVYGPHQYPEKVIPKFISLLQHNRKCCIHGSGLQTRNFLYATDVVE
Sbjct: 181 WEQYKFPVVITRSSNVYGPHQYPEKVIPKFISLLQHNRKCCIHGSGLQTRNFLYATDVVE 240
Query: 241 AFLTVLKKGKPGEIYNIGTNFEMSVVQLAKELIQLIKETNSESEMENWVDYVNDRPTNDM 300
AFLTVLKKGKPGEIYNIGTNFEMSVVQLAKELIQLIKETNSESEMENWVDYVNDRPTNDM
Sbjct: 241 AFLTVLKKGKPGEIYNIGTNFEMSVVQLAKELIQLIKETNSESEMENWVDYVNDRPTNDM 300
Query: 301 RYPMKSEKIHGLGWRPKVPWKEGIKKTIEWYRENFHNWKNVEKALEPFPV 350
RYPMKSEKIHGLGWRPKVPWKEGIKKTIEWYRENFHNWKNVEKALEPFPV
Sbjct: 301 RYPMKSEKIHGLGWRPKVPWKEGIKKTIEWYRENFHNWKNVEKALEPFPV 350
>gi|42516563 UDP-glucuronate decarboxylase 1 [Homo sapiens]
Length = 420
Score = 108 bits (270), Expect = 7e-24
Identities = 85/339 (25%), Positives = 146/339 (43%), Gaps = 25/339 (7%)
Query: 18 KRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDI 77
KR+L+TGGAGF+ SH+ L+ D + + +D + +N+E +N++ I D+
Sbjct: 89 KRILITGGAGFVGSHLTDKLMMD--GHEVTVVDNF-FTGRKRNVEHWIGHENFELINHDV 145
Query: 78 CDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKF 137
+ ++ ++D + H A+ + N GT ++ A +
Sbjct: 146 VEPLYI-------EVDQIYHLASPASPPNYMYNPIKTLKTNTIGTLNMLGLAKRVGA-RL 197
Query: 138 IYVSTDEVYGG-----SLDKEFDESSPKQPTNPYASSKAAAECFVQSYWEQYKFPVVITR 192
+ ST EVYG + + +P P Y K AE +Y +Q V + R
Sbjct: 198 LLASTSEVYGDPEVHPQSEDYWGHVNPIGPRACYDEGKRVAETMCYAYMKQEGVEVRVAR 257
Query: 193 SSNVYGP--HQYPEKVIPKFISLLQHNRKCCIHGSGLQTRNFLYATDVVEAFLTVLKKGK 250
N +GP H +V+ FI ++GSG QTR F Y +D+V + ++
Sbjct: 258 IFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALMNSNV 317
Query: 251 PGEIYNIGTNFEMSVVQLAKELIQLIKETNSESEMENWVDYVNDRPTNDMRYPMKSEKIH 310
+ N+G E ++++ A QLIK ++ D P + +K K+
Sbjct: 318 SSPV-NLGNPEEHTILEFA----QLIKNLVGSGSEIQFLSEAQDDP-QKRKPDIKKAKLM 371
Query: 311 GLGWRPKVPWKEGIKKTIEWYRENFHNWKNVEKALEPFP 349
LGW P VP +EG+ K I ++R+ N + +P P
Sbjct: 372 -LGWEPVVPLEEGLNKAIHYFRKELEYQANNQYIPKPKP 409
>gi|56118217 UDP-galactose-4-epimerase [Homo sapiens]
Length = 348
Score = 84.7 bits (208), Expect = 1e-16
Identities = 74/287 (25%), Positives = 132/287 (45%), Gaps = 35/287 (12%)
Query: 17 AKRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYC--------ASLKNLETISNKQ 68
A++VLVTGGAG+I SH ++ L+E Y+ + +D SL+ ++ ++ +
Sbjct: 2 AEKVLVTGGAGYIGSHTVLELLE--AGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGR- 58
Query: 69 NYKFIQGDICDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSA 128
+ +F + DI D ++ LF+ V+HFA V S + ++ VN+ GT L+
Sbjct: 59 SVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEI 118
Query: 129 AHEARVEKFIYVSTDEVYGGSLDKEFDESSPKQP-TNPYASSKAAAECFVQSYWEQYK-F 186
V+ ++ S+ VYG DE+ P TNPY SK E ++ + K +
Sbjct: 119 MKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTW 178
Query: 187 PVVITRSSNVYGPHQ----------YPEKVIPKFISLLQHNRKCCIH--------GSGLQ 228
V+ R N G H P ++P ++S + R+ ++ G
Sbjct: 179 NAVLLRYFNPTGAHASGCIGEDPQGIPNNLMP-YVSQVAIGRREALNVFGNDYDTEDGTG 237
Query: 229 TRNFLYATDVVEAFLTVLKKGKPG---EIYNIGTNFEMSVVQLAKEL 272
R++++ D+ + + L+K K IYN+GT SV+Q+ + +
Sbjct: 238 VRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAM 284
>gi|56237023 UDP-galactose-4-epimerase [Homo sapiens]
Length = 348
Score = 84.7 bits (208), Expect = 1e-16
Identities = 74/287 (25%), Positives = 132/287 (45%), Gaps = 35/287 (12%)
Query: 17 AKRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYC--------ASLKNLETISNKQ 68
A++VLVTGGAG+I SH ++ L+E Y+ + +D SL+ ++ ++ +
Sbjct: 2 AEKVLVTGGAGYIGSHTVLELLE--AGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGR- 58
Query: 69 NYKFIQGDICDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSA 128
+ +F + DI D ++ LF+ V+HFA V S + ++ VN+ GT L+
Sbjct: 59 SVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEI 118
Query: 129 AHEARVEKFIYVSTDEVYGGSLDKEFDESSPKQP-TNPYASSKAAAECFVQSYWEQYK-F 186
V+ ++ S+ VYG DE+ P TNPY SK E ++ + K +
Sbjct: 119 MKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTW 178
Query: 187 PVVITRSSNVYGPHQ----------YPEKVIPKFISLLQHNRKCCIH--------GSGLQ 228
V+ R N G H P ++P ++S + R+ ++ G
Sbjct: 179 NAVLLRYFNPTGAHASGCIGEDPQGIPNNLMP-YVSQVAIGRREALNVFGNDYDTEDGTG 237
Query: 229 TRNFLYATDVVEAFLTVLKKGKPG---EIYNIGTNFEMSVVQLAKEL 272
R++++ D+ + + L+K K IYN+GT SV+Q+ + +
Sbjct: 238 VRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAM 284
>gi|189083684 UDP-galactose-4-epimerase [Homo sapiens]
Length = 348
Score = 84.7 bits (208), Expect = 1e-16
Identities = 74/287 (25%), Positives = 132/287 (45%), Gaps = 35/287 (12%)
Query: 17 AKRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYC--------ASLKNLETISNKQ 68
A++VLVTGGAG+I SH ++ L+E Y+ + +D SL+ ++ ++ +
Sbjct: 2 AEKVLVTGGAGYIGSHTVLELLE--AGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGR- 58
Query: 69 NYKFIQGDICDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSA 128
+ +F + DI D ++ LF+ V+HFA V S + ++ VN+ GT L+
Sbjct: 59 SVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEI 118
Query: 129 AHEARVEKFIYVSTDEVYGGSLDKEFDESSPKQP-TNPYASSKAAAECFVQSYWEQYK-F 186
V+ ++ S+ VYG DE+ P TNPY SK E ++ + K +
Sbjct: 119 MKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTW 178
Query: 187 PVVITRSSNVYGPHQ----------YPEKVIPKFISLLQHNRKCCIH--------GSGLQ 228
V+ R N G H P ++P ++S + R+ ++ G
Sbjct: 179 NAVLLRYFNPTGAHASGCIGEDPQGIPNNLMP-YVSQVAIGRREALNVFGNDYDTEDGTG 237
Query: 229 TRNFLYATDVVEAFLTVLKKGKPG---EIYNIGTNFEMSVVQLAKEL 272
R++++ D+ + + L+K K IYN+GT SV+Q+ + +
Sbjct: 238 VRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAM 284
>gi|4504031 GDP-mannose 4,6-dehydratase [Homo sapiens]
Length = 372
Score = 70.1 bits (170), Expect = 3e-12
Identities = 70/285 (24%), Positives = 127/285 (44%), Gaps = 29/285 (10%)
Query: 69 NYKFIQGDICDSH-FVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVS 127
N K GD+ DS VK++ E + +I + AQ+HV +SF A V+ GT L+
Sbjct: 79 NMKLHYGDLTDSTCLVKIINEVKPTEIY-NLGAQSHVKISFDLAEYTADVDGVGTLRLLD 137
Query: 128 AAHEARV---EKFIYVSTDEVYGGSLDKEFDESSPKQPTNPYASSKAAAECFVQSYWEQY 184
A + KF ST E+YG + E++P P +PY ++K A V ++ E Y
Sbjct: 138 AVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAY 197
Query: 185 KF----PVVITRSSNVYGPHQYPEKVIPKFISLLQHNRKCCIHGSGLQTRNFLYATDVVE 240
++ S G + K+ + +C G+ R++ +A D VE
Sbjct: 198 NLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVE 257
Query: 241 AFLTVLKKGKP-------GEIYNIGTNFEMSVVQLAKELIQLIKETNSESEMENWVDYVN 293
A +L+ +P GE++++ E S + + K ++ E +E+E+ +
Sbjct: 258 AMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVW---EGKNENEVGRCKETGK 314
Query: 294 DRPTNDMRY--PMKSEKIHG--------LGWRPKVPWKEGIKKTI 328
T D++Y P + + + G L W+P+V + E +++ +
Sbjct: 315 VHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMV 359
>gi|4504507 3 beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 373
Score = 63.2 bits (152), Expect = 3e-10
Identities = 86/356 (24%), Positives = 136/356 (38%), Gaps = 52/356 (14%)
Query: 21 LVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDICDS 80
LVTG GF+ +I LV++ I LDK + + NK ++GDI D
Sbjct: 7 LVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELREEFSKLQNKTKLTVLEGDILDE 66
Query: 81 HFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKFIYV 140
F+K + + +++H A V VNV GT +L+ A +A V FIY
Sbjct: 67 PFLKR--ACQDVSVIIHTACIIDV-FGVTHRESIMNVNVKGTQLLLEACVQASVPVFIYT 123
Query: 141 STDEVYGGSLDKEF----DESSPKQPT--NPYASSKAAAE--CFVQSYWEQYKFPVVIT- 191
S+ EV G + KE E P + T PY SK AE + W + T
Sbjct: 124 SSIEVAGPNSYKEIIQNGHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGGTLYTC 183
Query: 192 --RSSNVYGPHQYPEKVIPKFISLLQHNRKCCIHGSGLQTRNFLYATDVVEAFLTVLK-- 247
R +YG + + I+ +N T N +Y +V A + L+
Sbjct: 184 ALRPMYIYGE---GSRFLSASINEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALRAL 240
Query: 248 ---KGKP---GEIYNIG-----TNFEMSVVQLAKEL-IQLIKETNSESEMENWVDYVND- 294
K P G+ Y I +++ L+KE ++L + + W+ ++ +
Sbjct: 241 QDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRLDSRWSFPLSLMYWIGFLLEI 300
Query: 295 -----RPTNDMRYPMKSEKI---------------HGLGWRPKVPWKEGIKKTIEW 330
RP R P + L ++P W+E +KT+EW
Sbjct: 301 VSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEW 356
>gi|116268111 short chain dehydrogenase/reductase family 42E, member
1 [Homo sapiens]
Length = 393
Score = 60.8 bits (146), Expect = 2e-09
Identities = 55/238 (23%), Positives = 106/238 (44%), Gaps = 29/238 (12%)
Query: 20 VLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDICD 79
VL+TGG+G+ + +L ++ + ++ ++ +TI + KFIQGDI
Sbjct: 11 VLITGGSGYFGFRLGCALNQNGVHVILFDISS--------PAQTIP--EGIKFIQGDIRH 60
Query: 80 SHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKFIY 139
V+ F+ + V H A+ + VNV GT ++ RV + +Y
Sbjct: 61 LSDVEKAFQDADVTCVFHIASYGMSGREQLNRNLIKEVNVRGTDNILQVCQRRRVPRLVY 120
Query: 140 VST-DEVYGGSLDKEFDESSPKQP----TNPYASSKAAAECFVQSYWEQYKFPV------ 188
ST + ++GG + + DES P P + Y+ +K+ AE Q E P+
Sbjct: 121 TSTFNVIFGGQVIRNGDESLPYLPLHLHPDHYSRTKSIAE---QKVLEANATPLDRGDGV 177
Query: 189 ---VITRSSNVYGPHQYPEKVIPKFISLLQHNRKCCIHGSGLQTRNFLYATDVVEAFL 243
R + +YGP + ++ +P+ +S ++ ++G F++ ++V+A +
Sbjct: 178 LRTCALRPAGIYGPGE--QRHLPRIVSYIEKGLFKFVYGDPRSLVEFVHVDNLVQAHI 233
>gi|4504509 3 beta-hydroxysteroid dehydrogenase 2 [Homo sapiens]
Length = 372
Score = 59.3 bits (142), Expect = 5e-09
Identities = 50/160 (31%), Positives = 70/160 (43%), Gaps = 9/160 (5%)
Query: 21 LVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDICDS 80
LVTG G + ++ LVE+ I LDK + + N+ ++GDI D
Sbjct: 6 LVTGAGGLLGQRIVRLLVEEKELKEIRALDKAFRPELREEFSKLQNRTKLTVLEGDILDE 65
Query: 81 HFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKFIYV 140
F+K + + +V+H A V VNV GT +L+ A +A V FIY
Sbjct: 66 PFLKRA--CQDVSVVIHTACIIDV-FGVTHRESIMNVNVKGTQLLLEACVQASVPVFIYT 122
Query: 141 STDEVYGGSLDKEF----DESSPKQPT--NPYASSKAAAE 174
S+ EV G + KE E P + T PY SK AE
Sbjct: 123 SSIEVAGPNSYKEIIQNGHEEEPLENTWPTPYPYSKKLAE 162
>gi|4507709 tissue specific transplantation antigen P35B [Homo
sapiens]
Length = 321
Score = 57.8 bits (138), Expect = 1e-08
Identities = 73/344 (21%), Positives = 142/344 (41%), Gaps = 48/344 (13%)
Query: 11 GLPGGFAKRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNY 70
G P G + R+LVTGG+G + I +V D L D+ +S+K
Sbjct: 2 GEPQG-SMRILVTGGSGLVGK-AIQKVVADGAG-----LPGEDWVF-------VSSKD-- 45
Query: 71 KFIQGDICDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRA-FEFTYVNVYGTHVLVSAA 129
D+ D+ + LFE + V+H AA ++ +F NV+ ++ +A
Sbjct: 46 ----ADLTDTAQTRALFEKVQPTHVIHLAAMVGGLFRNIKYNLDFWRKNVHMNDNVLHSA 101
Query: 130 HEARVEKFIYVSTDEVYGGSLDKEFDESS-----PKQPTNPYASSKAAAECFVQSYWEQY 184
E K + + ++ DE+ P Y+ +K + ++Y++QY
Sbjct: 102 FEVGARKVVSCLSTCIFPDKTTYPIDETMIHNGPPHNSNFGYSYAKRMIDVQNRAYFQQY 161
Query: 185 KFPVVITRSSNVYGPHQY----PEKVIPKFISLLQHNRKC----CIHGSGLQTRNFLYAT 236
+NV+GPH V+P I + + + G+G R F+Y+
Sbjct: 162 GCTFTAVIPTNVFGPHDNFNIEDGHVLPGLIHKVHLAKSSGSALTVWGTGNPRRQFIYSL 221
Query: 237 DVVEAFLTVLKKGKPGE--IYNIGTNFEMSVVQLAKELIQLIKETNSESEMENWVDYVND 294
D+ + F+ VL++ E I ++G E+S+ + A+ +++ M+ + D
Sbjct: 222 DLAQLFIWVLREYNEVEPIILSVGEEDEVSIKEAAEAVVE---------AMDFHGEVTFD 272
Query: 295 RPTNDMRYPMKSEKIHGLGWRPK---VPWKEGIKKTIEWYRENF 335
+D ++ + + P P+K+ +K+T W+ +N+
Sbjct: 273 TTKSDGQFKKTASNSKLRTYLPDFRFTPFKQAVKETCAWFTDNY 316
>gi|193211614 NAD(P) dependent steroid dehydrogenase-like [Homo
sapiens]
Length = 373
Score = 50.4 bits (119), Expect = 2e-06
Identities = 54/231 (23%), Positives = 93/231 (40%), Gaps = 23/231 (9%)
Query: 17 AKRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGD 76
AKR V GG+GF+ HM+ L+ Y ++ +++ + +F GD
Sbjct: 37 AKRCTVIGGSGFLGQHMVEQLL------------ARGYAVNVFDIQQGFDNPQVRFFLGD 84
Query: 77 ICDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEK 136
+C L + ++ V H A+ S F VN GT ++ EA V+K
Sbjct: 85 LCSRQ--DLYPALKGVNTVFHCASPPP---SSNNKELFYRVNYIGTKNVIETCKEAGVQK 139
Query: 137 FIYVSTDEVYGGSLD-KEFDESSP--KQPTNPYASSKAAAECFVQSYWEQYK-FPVVITR 192
I S+ V +D K E P +P + Y +K E V + K F R
Sbjct: 140 LILTSSASVIFEGVDIKNGTEDLPYAMKPIDYYTETKILQERAVLGANDPEKNFLTTAIR 199
Query: 193 SSNVYGPHQYPEKVIPKFISLLQHNRKCCIHGSGLQTRNFLYATDVVEAFL 243
++GP +++P I ++ + + G+G +F + +VV +
Sbjct: 200 PHGIFGPRD--PQLVPILIEAARNGKMKFVIGNGKNLVDFTFVENVVHGHI 248
>gi|8393516 NAD(P) dependent steroid dehydrogenase-like [Homo
sapiens]
Length = 373
Score = 50.4 bits (119), Expect = 2e-06
Identities = 54/231 (23%), Positives = 93/231 (40%), Gaps = 23/231 (9%)
Query: 17 AKRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGD 76
AKR V GG+GF+ HM+ L+ Y ++ +++ + +F GD
Sbjct: 37 AKRCTVIGGSGFLGQHMVEQLL------------ARGYAVNVFDIQQGFDNPQVRFFLGD 84
Query: 77 ICDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEK 136
+C L + ++ V H A+ S F VN GT ++ EA V+K
Sbjct: 85 LCSRQ--DLYPALKGVNTVFHCASPPP---SSNNKELFYRVNYIGTKNVIETCKEAGVQK 139
Query: 137 FIYVSTDEVYGGSLD-KEFDESSP--KQPTNPYASSKAAAECFVQSYWEQYK-FPVVITR 192
I S+ V +D K E P +P + Y +K E V + K F R
Sbjct: 140 LILTSSASVIFEGVDIKNGTEDLPYAMKPIDYYTETKILQERAVLGANDPEKNFLTTAIR 199
Query: 193 SSNVYGPHQYPEKVIPKFISLLQHNRKCCIHGSGLQTRNFLYATDVVEAFL 243
++GP +++P I ++ + + G+G +F + +VV +
Sbjct: 200 PHGIFGPRD--PQLVPILIEAARNGKMKFVIGNGKNLVDFTFVENVVHGHI 248
>gi|239745448 PREDICTED: hypothetical protein XP_002343493 [Homo
sapiens]
Length = 422
Score = 48.1 bits (113), Expect = 1e-05
Identities = 43/163 (26%), Positives = 76/163 (46%), Gaps = 18/163 (11%)
Query: 18 KRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDI 77
++VLVTGG G++ + L + + ++++ + + S + KFIQ D+
Sbjct: 34 QKVLVTGGGGYLGFSLGSHLAKSGTSVILLDRRRPQWELSPET----------KFIQADV 83
Query: 78 CDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKF 137
D + FE +D V H A+ ++ + +NV GT +++ RV +
Sbjct: 84 RDEEALYRAFEG--VDCVFHVASYGMSGAEKLQKEQIESINVGGTKLVIDVCVRRRVPRL 141
Query: 138 IYVSTDEV-YGGSLDKEFDESS-PKQP----TNPYASSKAAAE 174
IY ST V +GG ++ DE S P P + Y+ +KA A+
Sbjct: 142 IYTSTVNVAFGGKPIEQGDEDSVPYFPLDEHVDHYSRTKAIAD 184
>gi|19923621 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
steroid delta-isomerase 7 isoform a [Homo sapiens]
Length = 369
Score = 47.8 bits (112), Expect = 1e-05
Identities = 48/165 (29%), Positives = 72/165 (43%), Gaps = 15/165 (9%)
Query: 21 LVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDICDS 80
LVTGG GF+ H++ L++ P + + L+ L+T IQGD+ +
Sbjct: 13 LVTGGCGFLGEHVVRMLLQREPRLGELRVFDQHLGPWLEELKT--GPVRVTAIQGDVTQA 70
Query: 81 HFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTY--VNVYGTHVLVSAAHEARVEKFI 138
H ++ +V+H A V F RA T VNV GT ++ A + +
Sbjct: 71 H--EVAAAVAGAHVVIHTAGLVDV---FGRASPKTIHEVNVQGTRNVIEACVQTGTRFLV 125
Query: 139 YVSTDEVYG----GSLDKEFDESSPKQPT--NPYASSKAAAECFV 177
Y S+ EV G G +E +P + +PY SKA AE V
Sbjct: 126 YTSSMEVVGPNTKGHPFYRGNEDTPYEAVHRHPYPCSKALAEWLV 170
>gi|239756515 PREDICTED: similar to Putative 3-beta-HSD family
protein ENSP00000330812 [Homo sapiens]
Length = 422
Score = 47.8 bits (112), Expect = 1e-05
Identities = 43/163 (26%), Positives = 76/163 (46%), Gaps = 18/163 (11%)
Query: 18 KRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDI 77
++VLVTGG G++ + L + + ++++ + + S + KFIQ D+
Sbjct: 34 QKVLVTGGGGYLGFSLGSHLAKSGTSVILLDRRRPQWELSPET----------KFIQADV 83
Query: 78 CDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKF 137
D + FE +D V H A+ ++ + +NV GT +++ RV +
Sbjct: 84 RDEEALYHAFEG--VDCVFHVASYGMSGAEKLQKEQIESINVGGTKLVIDVCVRRRVPRL 141
Query: 138 IYVSTDEV-YGGSLDKEFDESS-PKQP----TNPYASSKAAAE 174
IY ST V +GG ++ DE S P P + Y+ +KA A+
Sbjct: 142 IYTSTVNVAFGGKPIEQGDEDSVPYFPLDEHVDHYSRTKAIAD 184
>gi|239751020 PREDICTED: hypothetical protein XP_002347673 [Homo
sapiens]
Length = 422
Score = 47.8 bits (112), Expect = 1e-05
Identities = 43/163 (26%), Positives = 76/163 (46%), Gaps = 18/163 (11%)
Query: 18 KRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDI 77
++VLVTGG G++ + L + + ++++ + + S + KFIQ D+
Sbjct: 34 QKVLVTGGGGYLGFSLGSHLAKSGTSVILLDRRRPQWELSPET----------KFIQADV 83
Query: 78 CDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKF 137
D + FE +D V H A+ ++ + +NV GT +++ RV +
Sbjct: 84 RDEEALYHAFEG--VDCVFHVASYGMSGAEKLQKEQIESINVGGTKLVIDVCVRRRVPRL 141
Query: 138 IYVSTDEV-YGGSLDKEFDESS-PKQP----TNPYASSKAAAE 174
IY ST V +GG ++ DE S P P + Y+ +KA A+
Sbjct: 142 IYTSTVNVAFGGKPIEQGDEDSVPYFPLDEHVDHYSRTKAIAD 184
>gi|218563686 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
steroid delta-isomerase 7 isoform b [Homo sapiens]
Length = 196
Score = 47.8 bits (112), Expect = 1e-05
Identities = 48/165 (29%), Positives = 72/165 (43%), Gaps = 15/165 (9%)
Query: 21 LVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDICDS 80
LVTGG GF+ H++ L++ P + + L+ L+T IQGD+ +
Sbjct: 13 LVTGGCGFLGEHVVRMLLQREPRLGELRVFDQHLGPWLEELKT--GPVRVTAIQGDVTQA 70
Query: 81 HFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTY--VNVYGTHVLVSAAHEARVEKFI 138
H ++ +V+H A V F RA T VNV GT ++ A + +
Sbjct: 71 H--EVAAAVAGAHVVIHTAGLVDV---FGRASPKTIHEVNVQGTRNVIEACVQTGTRFLV 125
Query: 139 YVSTDEVYG----GSLDKEFDESSPKQPT--NPYASSKAAAECFV 177
Y S+ EV G G +E +P + +PY SKA AE V
Sbjct: 126 YTSSMEVVGPNTKGHPFYRGNEDTPYEAVHRHPYPCSKALAEWLV 170
>gi|218563684 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
steroid delta-isomerase 7 isoform b [Homo sapiens]
Length = 196
Score = 47.8 bits (112), Expect = 1e-05
Identities = 48/165 (29%), Positives = 72/165 (43%), Gaps = 15/165 (9%)
Query: 21 LVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDICDS 80
LVTGG GF+ H++ L++ P + + L+ L+T IQGD+ +
Sbjct: 13 LVTGGCGFLGEHVVRMLLQREPRLGELRVFDQHLGPWLEELKT--GPVRVTAIQGDVTQA 70
Query: 81 HFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTY--VNVYGTHVLVSAAHEARVEKFI 138
H ++ +V+H A V F RA T VNV GT ++ A + +
Sbjct: 71 H--EVAAAVAGAHVVIHTAGLVDV---FGRASPKTIHEVNVQGTRNVIEACVQTGTRFLV 125
Query: 139 YVSTDEVYG----GSLDKEFDESSPKQPT--NPYASSKAAAECFV 177
Y S+ EV G G +E +P + +PY SKA AE V
Sbjct: 126 YTSSMEVVGPNTKGHPFYRGNEDTPYEAVHRHPYPCSKALAEWLV 170
>gi|33519455 methionine adenosyltransferase II, beta isoform 2 [Homo
sapiens]
Length = 323
Score = 33.1 bits (74), Expect = 0.38
Identities = 30/105 (28%), Positives = 50/105 (47%), Gaps = 4/105 (3%)
Query: 71 KFIQGDICDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAH 130
KF Q ++ DS+ V + + +++H AA+ D+ + + +NV + L A
Sbjct: 55 KFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNLAKEA- 113
Query: 131 EARVEKF-IYVSTDEVYGGSLDKEFDESSPKQPTNPYASSKAAAE 174
A V F IY+S+D V+ G+ +E P P N Y +K E
Sbjct: 114 -AAVGAFLIYISSDYVFDGTNPPYREEDIP-APLNLYGKTKLDGE 156
>gi|11034825 methionine adenosyltransferase II, beta isoform 1 [Homo
sapiens]
Length = 334
Score = 33.1 bits (74), Expect = 0.38
Identities = 30/105 (28%), Positives = 50/105 (47%), Gaps = 4/105 (3%)
Query: 71 KFIQGDICDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAH 130
KF Q ++ DS+ V + + +++H AA+ D+ + + +NV + L A
Sbjct: 66 KFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNLAKEA- 124
Query: 131 EARVEKF-IYVSTDEVYGGSLDKEFDESSPKQPTNPYASSKAAAE 174
A V F IY+S+D V+ G+ +E P P N Y +K E
Sbjct: 125 -AAVGAFLIYISSDYVFDGTNPPYREEDIP-APLNLYGKTKLDGE 167
>gi|7656940 chromosome 1 open reading frame 9 protein isoform 1
[Homo sapiens]
Length = 1254
Score = 31.6 bits (70), Expect = 1.1
Identities = 21/70 (30%), Positives = 33/70 (47%), Gaps = 6/70 (8%)
Query: 82 FVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKFIYVS 141
+VK+ + K++++ HF ++ LS +R F + V Y + S H R E F
Sbjct: 419 YVKMFIKYIKVELLSHFGSEHFCPLSLIRVFGTSMVEEY-EEIADSQYHSERQELF---- 473
Query: 142 TDEVYGGSLD 151
DE Y LD
Sbjct: 474 -DEDYDYPLD 482
>gi|31542658 fatty acyl CoA reductase 2 [Homo sapiens]
Length = 515
Score = 31.2 bits (69), Expect = 1.4
Identities = 36/169 (21%), Positives = 68/169 (40%), Gaps = 26/169 (15%)
Query: 18 KRVLVTGGAGFIASHMIVSLVEDYPNYMIINL---DKLDYCASLKNLETISNK------- 67
K +L+TG GF+ ++ L P+ +I + K + + + +K
Sbjct: 11 KSILITGATGFLGKVLMEKLFRTSPDLKVIYILVRPKAGQTLQQRVFQILDSKLFEKVKE 70
Query: 68 ------QNYKFIQGDICDSHFVKLLFETEKI----DIVLHFAAQTHVDLSFVRAFEFTYV 117
+ + I D+ + F + +++ +I+ H AA D + A + +
Sbjct: 71 VCPNVHEKIRAIYADLNQNDFAISKEDMQELLSCTNIIFHCAATVRFDDTLRHAVQ---L 127
Query: 118 NVYGT-HVLVSAAHEARVEKFIYVSTDEVYGGSLDKEFDESSPKQPTNP 165
NV T +L+ A+ ++E FI++ST Y K DE P P
Sbjct: 128 NVTATRQLLLMASQMPKLEAFIHIST--AYSNCNLKHIDEVIYPCPVEP 174
>gi|253314447 RAD52 motif 1 isoform 5 [Homo sapiens]
Length = 228
Score = 29.3 bits (64), Expect = 5.5
Identities = 17/50 (34%), Positives = 26/50 (52%)
Query: 273 IQLIKETNSESEMENWVDYVNDRPTNDMRYPMKSEKIHGLGWRPKVPWKE 322
I L++E + E E+ V RP+ D+ E++HGL P PWK+
Sbjct: 154 IGLVEEPMDKVEEESGKIAVEYRPSEDIVGVRCEEELHGLIQVPCSPWKQ 203
>gi|253314445 RAD52 motif 1 isoform 4 [Homo sapiens]
Length = 251
Score = 29.3 bits (64), Expect = 5.5
Identities = 17/50 (34%), Positives = 26/50 (52%)
Query: 273 IQLIKETNSESEMENWVDYVNDRPTNDMRYPMKSEKIHGLGWRPKVPWKE 322
I L++E + E E+ V RP+ D+ E++HGL P PWK+
Sbjct: 177 IGLVEEPMDKVEEESGKIAVEYRPSEDIVGVRCEEELHGLIQVPCSPWKQ 226
>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
Length = 1233
Score = 29.3 bits (64), Expect = 5.5
Identities = 27/93 (29%), Positives = 42/93 (45%), Gaps = 10/93 (10%)
Query: 257 IGTNFEMSVVQLAK---ELIQLIKETNSESEMENWVDYVNDRPTNDMRYPMKSEK--IHG 311
+G N + +V K + IQ IKE E E +DY+ +PT++ +K K I
Sbjct: 538 LGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDV 597
Query: 312 LGWRPKVPWKEGIKKTIEWYRENFHNWKNVEKA 344
+ + P IKK +++ N NVE A
Sbjct: 598 IRYEP-----PHIKKALQYACGNALVCDNVEDA 625
>gi|4505363 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5,
16kDa precursor [Homo sapiens]
Length = 189
Score = 28.5 bits (62), Expect = 9.4
Identities = 14/42 (33%), Positives = 23/42 (54%), Gaps = 3/42 (7%)
Query: 174 ECFVQSYWEQYKFPVVITRSSNVYGPHQYPEKVIPKFISLLQ 215
E +V +WE YK P+ + N Y PEK+ + +++LQ
Sbjct: 103 EGYVPEHWEYYKHPISRWIARNFY---DSPEKIYERTMAVLQ 141
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 28.5 bits (62), Expect = 9.4
Identities = 35/151 (23%), Positives = 69/151 (45%), Gaps = 19/151 (12%)
Query: 8 EPWGLPGGFAKRVLVTGGAGFIASHMIVSLVEDYPNYMII--NLDKLDYCASLKNLETIS 65
+P LPG V+VTGG+ I + + + ++ N DKL + +I+
Sbjct: 26 KPLALPGA---HVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSIN 82
Query: 66 NKQNYKFIQGDIC-DSHFVKLLFETEK-----IDIVLHFAAQT----HVDL---SFVRAF 112
+KQ I D+ D + V+ + + + +D++++ A DL +F R
Sbjct: 83 DKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLM 142
Query: 113 EFTYV-NVYGTHVLVSAAHEARVEKFIYVST 142
Y+ +VY + +++ E RV + ++VS+
Sbjct: 143 SINYLGSVYPSRAVITTMKERRVGRIVFVSS 173
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,270,556
Number of Sequences: 37866
Number of extensions: 545200
Number of successful extensions: 1377
Number of sequences better than 10.0: 27
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 1339
Number of HSP's gapped (non-prelim): 31
length of query: 350
length of database: 18,247,518
effective HSP length: 103
effective length of query: 247
effective length of database: 14,347,320
effective search space: 3543788040
effective search space used: 3543788040
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.