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Search of human proteins with 7657138
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7657138 golgi integral membrane protein 4 [Homo sapiens]
(696 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7657138 golgi integral membrane protein 4 [Homo sapiens] 1398 0.0
gi|148746195 trichohyalin [Homo sapiens] 130 3e-30
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 117 5e-26
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 115 1e-25
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 113 5e-25
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 106 6e-23
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 96 1e-19
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 96 1e-19
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 96 1e-19
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 96 1e-19
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 96 1e-19
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 96 1e-19
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 96 1e-19
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 96 1e-19
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 95 2e-19
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 93 9e-19
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 92 2e-18
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 91 3e-18
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 91 3e-18
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 91 3e-18
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 90 6e-18
gi|44890059 involucrin [Homo sapiens] 90 8e-18
gi|221139761 zinc finger protein 853 [Homo sapiens] 89 2e-17
gi|21735548 centrosomal protein 2 [Homo sapiens] 89 2e-17
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 87 4e-17
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 87 4e-17
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 87 4e-17
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 87 5e-17
gi|31982906 cingulin-like 1 [Homo sapiens] 87 7e-17
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 86 9e-17
>gi|7657138 golgi integral membrane protein 4 [Homo sapiens]
Length = 696
Score = 1398 bits (3618), Expect = 0.0
Identities = 696/696 (100%), Positives = 696/696 (100%)
Query: 1 MGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQ 60
MGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQ
Sbjct: 1 MGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQ 60
Query: 61 LQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQM 120
LQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQM
Sbjct: 61 LQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQM 120
Query: 121 LKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLRE 180
LKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLRE
Sbjct: 121 LKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLRE 180
Query: 181 ENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDT 240
ENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDT
Sbjct: 181 ENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDT 240
Query: 241 LNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAE 300
LNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAE
Sbjct: 241 LNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAE 300
Query: 301 DTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEE 360
DTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEE
Sbjct: 301 DTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEE 360
Query: 361 HDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQ 420
HDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQ
Sbjct: 361 HDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQ 420
Query: 421 VEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQ 480
VEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQ
Sbjct: 421 VEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQ 480
Query: 481 AHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEA 540
AHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEA
Sbjct: 481 AHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEA 540
Query: 541 DRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAG 600
DRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAG
Sbjct: 541 DRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAG 600
Query: 601 NPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEV 660
NPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEV
Sbjct: 601 NPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEV 660
Query: 661 RDDNRPKGREEHYEEEEEEEEDGAAVAEKSHRRAEM 696
RDDNRPKGREEHYEEEEEEEEDGAAVAEKSHRRAEM
Sbjct: 661 RDDNRPKGREEHYEEEEEEEEDGAAVAEKSHRRAEM 696
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 130 bits (328), Expect = 3e-30
Identities = 160/723 (22%), Positives = 308/723 (42%), Gaps = 71/723 (9%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKL 94
E + + RK E V K ++ + Q Q + + L+++ L ++ +E+ +L
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL 300
Query: 95 EAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHK 154
++ L + +++ + Q + Q EE ++Q E+E R++ + + +
Sbjct: 301 RREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERR 360
Query: 155 QKYLQLQQEKEQELSKLKETVYNLREE----NRQLRKAHQDIHTQLQDVKQQ--HKNLLS 208
++ L+ +QE+E+ +L+ RE+ +QLR+ Q Q +QQ + L
Sbjct: 361 EQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 420
Query: 209 EHEQLVVTLEDHKSALAAAQTQ-----VAEYKQLKDTLNRIPSLRKPDP---AEQQNVTQ 260
+QL E+ + Q + E ++ +D L R + + +Q Q
Sbjct: 421 REQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQ 480
Query: 261 VAHSPQGYNTAREKPTREVQE----VSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQA 316
+ + E+ RE QE R + + + + E+ +L E + +
Sbjct: 481 EEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRR 540
Query: 317 PPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQH 376
E ++++ +RE E+ +E + L+ E+ E+ Q EEE Q R +EQ
Sbjct: 541 EQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE-----RRQQRLKREQE 595
Query: 377 EQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQ--LREHQEAL 434
E+ E E R E + +K + P EE+ +Q + +Q E QQ RE QE
Sbjct: 596 ERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERR 655
Query: 435 HQ--------QRLQGHLLR--QQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYD 484
Q +RL+ L R ++E+++Q++A E Q + ++ P+ Q QL +A D
Sbjct: 656 EQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEA--D 713
Query: 485 AMDNDIV-----QGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPR------E 533
A + + Q + + + EE R+++ Q + E + +R + E+ R +
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE-ERAHRQQQEEEQRRDFTWQWQ 772
Query: 534 ADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQEN---- 589
A+ +SE R + P + + + EE +Q + LP+E E++++ Q++E
Sbjct: 773 AEEKSERGRQRLSARPPLRE-QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL 831
Query: 590 --TEVEEHL---VMAGNPDQQEDNVDEQYQEEAEEEVQED------LTEEKKRELEHNAE 638
E EE L A ++ED + E + +E + D L EE+KR
Sbjct: 832 QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYA 891
Query: 639 ETYGENDENTDDKNNDGEEQEVRDDNRPKGR----EEHYEEEE--EEEEDGAAVAEKSHR 692
+ + + + EE+E++ + R K R E Y EEE ++EE+ E+ R
Sbjct: 892 KPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKR 951
Query: 693 RAE 695
R +
Sbjct: 952 RRQ 954
Score = 130 bits (327), Expect = 4e-30
Identities = 175/746 (23%), Positives = 301/746 (40%), Gaps = 149/746 (19%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQL----QVVYEHRSRLEKSLQKE---RLEHKKAKE 87
+L+ + + LK Q+ +E L +L Q+ E R E+ L++E RLE ++ ++
Sbjct: 506 QLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQ 565
Query: 88 DFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFS 147
+ E ++ L K ++ + Q LK + EE +Q EE R + E+
Sbjct: 566 RLKREQEERRDQLLKREEER---------RQQRLKREQEERLEQRLKREEVERLEQEER- 615
Query: 148 RTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLL 207
+ + K + ++E+ Q+L K +E +EE RQ Q + + Q+ ++Q
Sbjct: 616 ---REQRLKREEPEEERRQQLLKSEE-----QEERRQ-----QQLRREQQERREQRLKRE 662
Query: 208 SEHEQLVVTLE-DHKSALAAAQTQVAEYKQLKDTL-NRIPS----LRKPDPAEQQNVTQV 261
E E+L L+ +H+ + E +Q ++ + +RIP L A Q V
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSR 722
Query: 262 AHSPQGYNTAREKPT------------------REVQEVSRNNDV---WQNHEAVPGRAE 300
+G +E+ R+ QE + D WQ E +
Sbjct: 723 PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ 782
Query: 301 DTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALE----------EEEMEQ 350
P ++ E Q E QQ +R PEE + E+ R+ E EE++++
Sbjct: 783 RLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQR 842
Query: 351 VGQAEHLEEEHDPSPEEQDRE--WKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYE 408
+A+ L+EE D E+Q+R +++ +Q+ L E R AKP ++ Q E
Sbjct: 843 RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKE 902
Query: 409 EQLEQQRLAVQQVEEAQ------QLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQR 462
+QL Q+ Q EE + Q R+++E Q+ + LLR++ +++++ RE ++
Sbjct: 903 QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRK 962
Query: 463 QAEL--------------------------EEGRPQHQEQL---------RQQAHYDAMD 487
+L EE Q +EQL RQ+
Sbjct: 963 DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022
Query: 488 NDIVQGAEDQ---------GIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPES 538
D +Q E+Q +Q E Y + + Q E E G E R + E
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK 1082
Query: 539 EADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQ--KQSNQKQENTEVEEHL 596
E + E+ ++P + E E Q REE + EEQ ++ +K+ E+E
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERER--QCREEEELQQEEEQLLREEREKRRRQELE--- 1137
Query: 597 VMAGNPDQQEDNVDEQYQEEAEEEVQED--LTEEKKRELEHNAEETYGENDENTDDKNND 654
QY+EE E + +E+ L EE ++ E Y E +E +
Sbjct: 1138 --------------RQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE---- 1179
Query: 655 GEEQEVRD--DNRPKGREEHYEEEEE 678
EEQ +R+ + R + RE Y EEEE
Sbjct: 1180 -EEQLLREEQEKRRQERERQYREEEE 1204
Score = 124 bits (312), Expect = 2e-28
Identities = 142/693 (20%), Positives = 294/693 (42%), Gaps = 53/693 (7%)
Query: 37 QTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKA-KEDFLVYKLE 95
+ QLR+ + + + Q +E + Q H + E+ +++RL+ ++ + D+L + E
Sbjct: 404 EQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEE 463
Query: 96 AQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDF--SRTFNDH 153
+ + R+ R + + LK + EE ++Q E++ R++ E+ R
Sbjct: 464 TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQE 523
Query: 154 KQKYLQLQQEKEQELSKLKETVYNL---REENRQLRKAHQDIHTQLQDVKQQHKNLLSEH 210
+++ LQ + EQ+L + +E REE ++L + ++ + + +++ + L E
Sbjct: 524 EEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREE 583
Query: 211 EQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQG--- 267
E+ L+ + + + E ++L+ R L++ +P E++ + Q
Sbjct: 584 ERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERR 643
Query: 268 -YNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVE 326
RE+ R Q + R + + + + E+ + +E + QA E I+ +
Sbjct: 644 QQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR-ERIKSRIP 702
Query: 327 RREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKE-------QHEQR 379
+ + + + + + +Q GQ E+E E + +W+E Q E+
Sbjct: 703 KWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE 762
Query: 380 EAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRL 439
+ + E + + + P EQ E+Q A ++ + Q+ +E Q+R
Sbjct: 763 QRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRR 822
Query: 440 QGHLLRQQ----EQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAE 495
Q ++ E+++Q RE A Q Q E E+G + QE+ R Q +
Sbjct: 823 QRREREKELQFLEEEEQLQRRERAQQLQEE-EDGLQEDQERRRSQ-----------EQRR 870
Query: 496 DQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPN 555
DQ + + + +H A+ P + + R++ + E E R E +
Sbjct: 871 DQKWRWQLEEERKRRRHTLYAK--PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER 928
Query: 556 NQGEDEF---EEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQ---QEDNV 609
E+E EE + +REE +E+++ +K + + +E ++ P++ QE
Sbjct: 929 QYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREK 988
Query: 610 DEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQ---EVRDDNRP 666
+ +EE ++E ++ L EE+++ E Y + DE + EEQ E R+ R
Sbjct: 989 KYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE-----EEQLLREEREKRRL 1043
Query: 667 KGREEHYEEE---EEEEEDGAAVAEKSHRRAEM 696
+ RE Y EE ++EEE ++ RR E+
Sbjct: 1044 QERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Score = 123 bits (308), Expect = 7e-28
Identities = 130/582 (22%), Positives = 247/582 (42%), Gaps = 49/582 (8%)
Query: 136 EEEHRKQGEDFSRTFNDHK-QKYLQLQQEKEQELSKLKE-TVYNLREENRQLRKAHQDIH 193
+EE +++ E R + Q+ Q +QE+E+EL++ +E + R E R ++ +++
Sbjct: 115 QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELW 174
Query: 194 TQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPA 253
Q Q+ Q+ + +E EQL + + H++ + Q+ + L+ LR+
Sbjct: 175 RQRQEW-QEREERRAEEEQLQ-SCKGHETEEFPDEEQLRRRELLE--------LRRKGRE 224
Query: 254 EQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAE 313
E+Q RE+ R QE W+ E V + E+ ++ E
Sbjct: 225 EKQQ------------QRRERQDRVFQEEEEKE--WRKRETVLRKEEEKLQEEEPQRQRE 270
Query: 314 FQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDR--- 370
Q E +++ + E Q EE+ ++ L E+ + Q E E+ + E+Q+R
Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ 330
Query: 371 --EWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLR 428
E +EQ +RE E R E + + EE+ EQQ QQ+ QQLR
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390
Query: 429 EHQEALHQQRLQGHLLRQQEQQ---QQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDA 485
Q+ +Q+L+ ++EQQ +QQ+ RE L+R+ E E +H+++ R+Q
Sbjct: 391 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE 450
Query: 486 MD--NDIVQGAEDQGIQGEEGAYERDNQHQDE---------AEGDPGNRHEPREQGPREA 534
+ D ++ E+ +E ++ + Q+E E + + E REQ R
Sbjct: 451 QEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE 510
Query: 535 DPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEE 594
E R ++ + E + ++ R E L EE++ +++E E
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE 570
Query: 595 HLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKR-ELEHNAEETYGENDENTDDKNN 653
DQ +E+ Q+ + E +E L + KR E+E +E E ++
Sbjct: 571 ---QEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEE 627
Query: 654 DGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVAEKSHRRAE 695
+ +Q ++ + + + R++ E++E + E+ R E
Sbjct: 628 ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE 669
Score = 120 bits (301), Expect = 4e-27
Identities = 140/675 (20%), Positives = 299/675 (44%), Gaps = 66/675 (9%)
Query: 37 QTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEA 96
Q + +K + + + +E Q ++ R R ++ L ++R E ++ +E +
Sbjct: 135 QRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREE-----RRAE 189
Query: 97 QETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQK 156
+E L + + + Q+ + + EL+++ + +++ R++ +D R F
Sbjct: 190 EEQLQSCKGHETEEFPD---EEQLRRRELLELRRKGREEKQQQRRERQD--RVF------ 238
Query: 157 YLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVT 216
Q+E+E+E K +ETV LR+E +L++ +LQ+ ++Q + L E ++L
Sbjct: 239 ----QEEEEKEWRK-RETV--LRKEEEKLQEEEPQRQRELQEEEEQLRKL--ERQELRRE 289
Query: 217 LEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPT 276
++ + Q ++ +QL+ ++ + EQQ + + RE+
Sbjct: 290 RQEEEQQ----QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE 345
Query: 277 REVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPE---EH 333
R Q++ R + + + + E+ + +E + + + +++ RRE + E
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Query: 334 QVEEEHRKALEEE-EMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAE 392
Q+ E + E++ EQ + E EE H+ E++ RE + + EQ E + L+ E
Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE 465
Query: 393 VYPSAKPMIKFQSPYEEQ-------LEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLR 445
+ + + + EE+ LE++ QQ QQLR QE +QRL+
Sbjct: 466 RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQ--E 523
Query: 446 QQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGA 505
++E+ QQ++ E L+R+ QE+ R+Q + + Q +Q ++ E+
Sbjct: 524 EEERLQQRLRSEQQLRRE----------QEERREQLLKREEEKRLEQERREQRLKREQEE 573
Query: 506 YERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEA 565
RD + E E R + R + +E E R VE + + + + EE
Sbjct: 574 -RRDQLLKREEE-----RRQQRLKREQEERLEQRLKREEVERLE--QEERREQRLKREEP 625
Query: 566 EQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQE-D 624
E+ R + L ++EEQ++ Q+Q E +E +++E+ ++++ + E EEE +E +
Sbjct: 626 EEERRQQLL-KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE 684
Query: 625 LTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEE----EE 680
L EE++ + + + + + + + + + +G+ E+EE+ E
Sbjct: 685 LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRES 744
Query: 681 EDGAAVAEKSHRRAE 695
E E++HR+ +
Sbjct: 745 ELQWQEEERAHRQQQ 759
Score = 114 bits (284), Expect = 4e-25
Identities = 163/758 (21%), Positives = 305/758 (40%), Gaps = 126/758 (16%)
Query: 35 ELQTQLRKAEAVALKYQQ----HQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFL 90
EL+ Q R+ E + + +Q QE + + Y L++ +K+R + + D L
Sbjct: 1165 ELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSD-L 1223
Query: 91 VYKLEAQE--------TLNKGRQDSNSRY---SALNVQHQMLKSQHEELKKQHSDLEEEH 139
++ E ++ KGR++ R S L + QH ++Q D E+E
Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQE- 1282
Query: 140 RKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDV 199
R++ + R F + +Q + Q+E ++ K +E LREE + R+ Q+ + ++
Sbjct: 1283 RRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRR-RQETDRKFREE 1341
Query: 200 KQQHKNLLSEHEQLVVTLEDHKSALAAA----QTQVAEYKQLKDTLNRIPSLRKPDPAEQ 255
+Q LL E E+ + ++ Q Q ++ + + L R RK EQ
Sbjct: 1342 EQ----LLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQ 1397
Query: 256 QNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQ 315
Q Q RE Q + ++ E R E + + ++ Q
Sbjct: 1398 QLRCQ---------------EREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ 1442
Query: 316 APPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEH----LEEEHDPSPEEQDRE 371
+E ++ E H+ E + L+E E +Q+ + E LEEE +E+DR+
Sbjct: 1443 ERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRK 1502
Query: 372 WKEQHEQR--------EAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEE 423
++EQ + E L R + + ++ Q +++ + + ++ E+
Sbjct: 1503 FREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQ 1562
Query: 424 AQQLREHQEALHQQR-----LQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQH----- 473
+Q RE Q+ Q+R L+ +R+QEQ+++ + E L+RQ ++ R +
Sbjct: 1563 LRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFR 1622
Query: 474 ------QEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGA--YERDNQHQDEA----EGDPG 521
QE+ QQ H D ++ Q E ++RD + ++E EG+
Sbjct: 1623 EDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQ 1682
Query: 522 N-RHEPREQGPREADPESEADRAAVEDINPADDPNNQG-EDEFEEAEQVR---------- 569
R + R++ RE + + + + Q E +F E EQ+R
Sbjct: 1683 QLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRR 1742
Query: 570 ---------EENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQ--EDNVDEQYQEEAE 618
EE L E EEQ+ Q+++ EE + +QQ D +++EE +
Sbjct: 1743 QERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQ 1802
Query: 619 ---------------------EEVQEDLTEEKKR-----ELEHNAEETYGENDENTDDKN 652
EE Q L E+++R + ++ AEE + +++ ++
Sbjct: 1803 LRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQ 1862
Query: 653 N--DGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVAE 688
EEQ+ R + K REEH +++EE+ V E
Sbjct: 1863 ELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGE 1900
Score = 113 bits (282), Expect = 7e-25
Identities = 139/612 (22%), Positives = 269/612 (43%), Gaps = 49/612 (8%)
Query: 32 LYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLV 91
L E + + R+ + K+++ ++ L + + + R ++ ++E L H++ FL
Sbjct: 1320 LLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER-DRKFREEELRHQEQGRKFL- 1377
Query: 92 YKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDL---EEEHRKQGEDFSR 148
+E RQ+ ++ L + Q+ + E+ +Q D EEE + ++ R
Sbjct: 1378 -----EEEQRLRRQERERKF--LKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR 1430
Query: 149 TFNDHKQKYLQLQQEK---EQELSKLKETVYNLREENRQLR-KAHQDIHTQLQDVKQQHK 204
F + +Q+ + ++E+ E+E +E REE + L+ + Q +H Q +D K
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRK---- 1486
Query: 205 NLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDT--LNRIPSLRKPDPAEQQNVTQVA 262
L E +QL D K ++Q E K L++ L+R RK EQQ Q
Sbjct: 1487 -FLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQER 1545
Query: 263 HSPQGYNTARE-------KPTREVQEVSRN--NDVWQNHEAVPGRAEDTKLYAPTHKEAE 313
+ + R+ + RE Q++SR + ++ E R E + + ++
Sbjct: 1546 GQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR 1605
Query: 314 FQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWK 373
Q + ++QE +R+ E+ Q+ +E E++ Q + LEEE P Q+RE +
Sbjct: 1606 RQEGQQQLRQERDRKFREDEQLLQERE---EQQLHRQERDRKFLEEE--PQLRRQEREQQ 1660
Query: 374 EQHEQ----REAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLRE 429
+H++ RE LL+ ++ + KF+ E+QL +Q + ++E QQLR
Sbjct: 1661 LRHDRDRKFREEEQLLQEGEEQQLRRQERDR-KFREE-EQQLRRQERERKFLQEEQQLRR 1718
Query: 430 HQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAM--- 486
QE + R + L +QE +Q+Q+ R+ ++ E E+ RP+ +EQ ++ D
Sbjct: 1719 -QELERKFREEEQL--RQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFRE 1775
Query: 487 DNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVE 546
+ + Q E+Q ++ +E + + Q E + + G + E +
Sbjct: 1776 EEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ 1835
Query: 547 DINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQE 606
+ D + E++F E+ R E EE+++ Q++E EEH+ +Q+
Sbjct: 1836 RLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRH 1895
Query: 607 DNVDEQYQEEAE 618
V E +E +
Sbjct: 1896 RQVGEIKSQEGK 1907
Score = 112 bits (279), Expect = 2e-24
Identities = 158/741 (21%), Positives = 309/741 (41%), Gaps = 107/741 (14%)
Query: 41 RKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETL 100
RK E + +Q ++ + ++ ++ R + Q+E + + DF ++ +A+E
Sbjct: 724 RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEE-----EQRRDF-TWQWQAEEKS 777
Query: 101 NKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQL 160
+GRQ ++R + + L+++ + ++Q EEE ++Q R ++K LQ
Sbjct: 778 ERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQ----RRRQRREREKELQF 833
Query: 161 QQEKEQ-----ELSKLKETVYNLREENRQLR----KAHQDIHTQLQDVKQQHKNLLSEHE 211
+E+EQ +L+E L+E+ + R + Q QL++ +++ ++ L
Sbjct: 834 LEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP 893
Query: 212 QLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTA 271
L L + L + ++ ++ K + + QQ Q+
Sbjct: 894 ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREE------ 947
Query: 272 REKPTREVQEVSRNND--VWQNHEAVPG-------RAEDTKLYAPTHKEAEFQAPPEPI- 321
REK R+ +E D + Q E + G R E K Y +E E Q E +
Sbjct: 948 REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY---REEEELQQEEEQLL 1004
Query: 322 --------QQEVER--REPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDRE 371
+QE ER R+ +E Q EEE + EE E ++ + E E + +E+++
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEE-QLLREEREKRRLQERERQYREEEELQQEEEQL 1063
Query: 372 WKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQ----- 426
E+ E R L + + E + + + P + + +++ ++ EE QQ
Sbjct: 1064 LGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL 1123
Query: 427 LREHQEALHQQRLQGHLLRQQE--QQQQQVARE-------MALQRQAELEEGRPQHQEQL 477
LRE +E +Q L+ ++E Q+++Q+ RE L+RQ EE Q +EQL
Sbjct: 1124 LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQL 1183
Query: 478 RQQAHYDAMDNDIVQGAEDQGIQGE--EGAYERDNQHQD-EAEGDPGNRHEPREQGPREA 534
++ Q E++ +Q + + Y ++Q D + + +P + R+
Sbjct: 1184 LREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCK 1243
Query: 535 DPESEADRAAVEDINPADDPNNQ------GEDEFEEAE------QVREENLPD----ENE 578
E+E R +ED D + Q GE + + E Q R+ + P+ E E
Sbjct: 1244 GRENEQFR-QLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLERE 1302
Query: 579 EQKQSNQKQENTEVEEHLVMAGNPD-QQEDNVDEQYQEEAE--EEVQEDLTEEKKRELEH 635
EQK++ ++ ++ E+ L+ + ++ D +++EE + +E +E ++R+ +
Sbjct: 1303 EQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKF 1362
Query: 636 NAEETYGEN------DENTDDKNNDGE---------------EQEVRDDNRPKGREEHYE 674
EE + +E + + E EQ++R D K REE +
Sbjct: 1363 REEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQ 1422
Query: 675 EEEEEEEDGAAVAEKSHRRAE 695
+E + E+ RR E
Sbjct: 1423 LSRQERDRKFREEEQQVRRQE 1443
Score = 110 bits (274), Expect = 6e-24
Identities = 165/713 (23%), Positives = 304/713 (42%), Gaps = 117/713 (16%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKL 94
EL+ Q RK E + QQ +E L L+ E R R E+ Q E + +E+ L+
Sbjct: 1075 ELERQYRKEEEL----QQEEEQL---LREEPEKRRRQERERQCREEEELQQEEEQLL--- 1124
Query: 95 EAQETLNKGRQDSNSRY----SALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTF 150
+E + RQ+ +Y + Q+L+ + E+ ++Q +LE ++R++ E
Sbjct: 1125 -REEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQ--ELERQYREEEE------ 1175
Query: 151 NDHKQKYLQLQQEKEQELSKLKETVYNLREE-NRQLRKAHQDIHTQLQDVKQQHKNLLSE 209
+Q+ QL +E++++ + +E Y EE RQ RK Q D+K Q + E
Sbjct: 1176 --LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWE---PE 1230
Query: 210 HEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYN 269
E V D+K + + +++QL+D+ R D QQ++ + Q +
Sbjct: 1231 KENAV---RDNKVYCKGRENE--QFRQLEDSQLR-------DRQSQQDLQHLLGEQQERD 1278
Query: 270 TAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERRE 329
RE+ R Q+ R+ E+ +L KEA+ + ++++ R E
Sbjct: 1279 --REQERRRWQQRDRHFP------------EEEQLEREEQKEAKRRDRKSQEEKQLLREE 1324
Query: 330 PEEHQVEEE-HRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQH--EQREAANLLE 386
EE + +E RK EEE++ Q + + L + E+DR+++E+ Q + LE
Sbjct: 1325 REEKRRRQETDRKFREEEQLLQEREEQPLRRQ------ERDRKFREEELRHQEQGRKFLE 1378
Query: 387 GHARAEVYPSAKPMIKFQSPY-----EEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQG 441
R + +K + E+QL Q R + EE Q R+ ++ ++ Q
Sbjct: 1379 EEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQ 1438
Query: 442 HLLRQQEQQQQQVAREMAL--QRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGI 499
+R+QE++++ + E L +R + E QE+ QQ H D ++ E+Q +
Sbjct: 1439 --VRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLE--EEQQL 1494
Query: 500 QGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESE--ADRAAVEDINPADDPNNQ 557
+ +E +R + Q+ +P + EQ + + + +
Sbjct: 1495 RRQER--DRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD 1552
Query: 558 GEDEFEEAEQVREENLPDEN-----------EEQKQSNQKQENTEVEEHLVMAGNPDQQE 606
+ +F E EQ+R+E + EEQK Q+QE +E+ + QQ+
Sbjct: 1553 RDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQ 1612
Query: 607 --------DNVDEQYQEEAEEE-----------VQED---LTEEKKRELEHNAEETYGEN 644
DEQ +E EE+ ++E+ +E++++L H+ + + E
Sbjct: 1613 LRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREE 1672
Query: 645 DENTDDKNNDGEEQEVRDDNRP-KGREEHYEEEEEEEEDGAAVAEKSHRRAEM 696
++ + GEEQ++R R K REE + +E E E+ RR E+
Sbjct: 1673 EQLLQE----GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQEL 1721
Score = 104 bits (259), Expect = 3e-22
Identities = 159/727 (21%), Positives = 302/727 (41%), Gaps = 103/727 (14%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKL 94
E + Q R+ E + QQ +E L + E R + L+++ E ++ +++ +L
Sbjct: 1105 ERERQCREEEEL----QQEEEQLLRE-----EREKRRRQELERQYREEEEVQQE--EEQL 1153
Query: 95 EAQETLNKGRQDSNSRY---SALNVQHQMLKSQHEELKKQHSDLE--EEHRKQGEDFSRT 149
+E + RQ+ +Y L + + L + +E ++Q + + EE Q + +
Sbjct: 1154 LREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR 1213
Query: 150 FNDHKQKY-LQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH--KNL 206
+ D Q+ L+ Q E E+E + VY EN Q R+ +QL+D + Q ++L
Sbjct: 1214 YRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLED---SQLRDRQSQQDLQHL 1270
Query: 207 LSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQ 266
L E ++ E + E +QL+ + R E++ Q+ +
Sbjct: 1271 LGEQQER--DREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK---QLLREER 1325
Query: 267 GYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAE--DTKLYAPTHKEAEFQAPPEPIQQE 324
R++ R+ +E + Q E P R + D K + E +Q
Sbjct: 1326 EEKRRRQETDRKFRE---EEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQR 1382
Query: 325 VERREPEEHQVEEEHRKALEEEEME--QVGQAEHLEEEHDPSPEEQDREWKEQHEQREAA 382
+ R+E E ++EE + +E E + Q + EEE S +E+DR+++E+ +Q
Sbjct: 1383 LRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ 1442
Query: 383 NLLEGHARAEVYPSAKPMIKF-------QSPYEEQLEQQRLAVQQVEEAQQLR------- 428
E + KF Q E+QL +Q + +EE QQLR
Sbjct: 1443 ERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRK 1502
Query: 429 ----------------EHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQ 472
E ++ LH+Q+ Q L Q++QQ+ R+ Q++ + + + +
Sbjct: 1503 FREQELRSQEPERKFLEEEQQLHRQQRQRKFL----QEEQQLRRQERGQQRRQDRDRKFR 1558
Query: 473 HQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPG-NRHEPREQGP 531
+EQLRQ+ + + + D+ + EE R Q + E + R E ++Q
Sbjct: 1559 EEEQLRQERE----EQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLR 1614
Query: 532 READPESEADRAAVEDINPADDPNNQGEDEF-EEAEQVREENLPDENEEQKQSNQKQENT 590
+E D + D +++ + + +F EE Q+R + E E+Q + ++ ++
Sbjct: 1615 QERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ----EREQQLRHDRDRKFR 1670
Query: 591 EVEEHLVMAGNPDQ-QEDNVDEQYQEE---------------AEEEVQEDLTEEKKRELE 634
E EE L+ G Q + D +++EE E++++ E K RE E
Sbjct: 1671 E-EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEE 1729
Query: 635 HNAEETYGENDENTDDKNNDGEEQEVRDDN-----RPKGREEHYEEEE---EEEEDGAAV 686
+ET E + EE+++R + R + R+ + EEE +E E+
Sbjct: 1730 QLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLR 1789
Query: 687 AEKSHRR 693
+++S R+
Sbjct: 1790 SQESDRK 1796
Score = 74.3 bits (181), Expect = 3e-13
Identities = 79/390 (20%), Positives = 164/390 (42%), Gaps = 54/390 (13%)
Query: 351 VGQAEHLEEE--------------------------HDPSPEEQDREWKEQHEQREAANL 384
+GQA L+EE D EE+ + + Q Q + L
Sbjct: 89 LGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQEREL 148
Query: 385 LEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLL 444
EG ++E + + + +E+L +QR Q+ +E ++ R +E L Q +GH
Sbjct: 149 AEGEEQSEKQERLEQ--RDRQRRDEELWRQR---QEWQEREERRAEEEQL--QSCKGHET 201
Query: 445 RQQEQQQQQVAREMALQRQAELEEGRPQHQEQ----LRQQAHYDAMDNDIVQGAEDQGIQ 500
+ ++Q RE+ R+ EE + Q +E+ +++ + + V E++ +Q
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261
Query: 501 GEEGAYERDNQHQDE-----AEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPN 555
EE +R+ Q ++E + + EQ + E + R E+ +
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321
Query: 556 NQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQE 615
+ ++ E+ E+ RE+ L E EE+++ ++E + EE +Q+E+ ++Q +
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLRRE--QEEERREQQLRREQEEERREQQLRR 379
Query: 616 EAEEEVQEDLTEEK--------KRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNR-- 665
E + ++ L E+ +RE + E+ + ++ E++E R + +
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439
Query: 666 PKGREEHYEEEEEEEEDGAAVAEKSHRRAE 695
+ RE+ + E+EE D E++ R +
Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQ 469
Score = 74.3 bits (181), Expect = 3e-13
Identities = 85/373 (22%), Positives = 159/373 (42%), Gaps = 64/373 (17%)
Query: 326 ERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLL 385
+RR+ E+ + E + LEEE ++ Q +EQ+RE E EQ E L
Sbjct: 112 DRRQEEDQRRFEPRDRQLEEEPGQRRRQKR----------QEQERELAEGEEQSEKQERL 161
Query: 386 EGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLR 445
E R +E+L +QR Q+ +E ++ R +E L Q +GH
Sbjct: 162 EQRDRQR--------------RDEELWRQR---QEWQEREERRAEEEQL--QSCKGHETE 202
Query: 446 QQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGA 505
+ ++Q RE+ R+ +GR + Q+Q R++ +D+ Q EE
Sbjct: 203 EFPDEEQLRRRELLELRR----KGREEKQQQRRER--------------QDRVFQEEEEK 244
Query: 506 YERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEA 565
R + E + EP+ Q RE E E R + + ++E ++
Sbjct: 245 EWRKRETVLRKEEEKLQEEEPQRQ--RELQEEEEQLRKLERQ-----ELRRERQEEEQQQ 297
Query: 566 EQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDL 625
+++R E +E+++ Q++E E +E +QQE+ ++Q + E EE ++ L
Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERR------EQQEERREQQLRREQEERREQQL 351
Query: 626 T---EEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEED 682
EE++RE + E+ ++ + EQ++R + + + RE+ E++ +
Sbjct: 352 RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLR-REQQLRREQQLRRE 410
Query: 683 GAAVAEKSHRRAE 695
E+ RR +
Sbjct: 411 QQLRREQQLRREQ 423
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 117 bits (292), Expect = 5e-26
Identities = 136/685 (19%), Positives = 304/685 (44%), Gaps = 76/685 (11%)
Query: 35 ELQTQLRKAEAVALKYQQ----HQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFL 90
EL+T L ++ A K++ + L+ +L + L+++L HKKA
Sbjct: 103 ELETALYYSQDAARKFEDGNLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYI- 161
Query: 91 VYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTF 150
E L K R AL+++ +EELKK++++L+E+ R + S
Sbjct: 162 -------EELTKERD-------ALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQ 207
Query: 151 NDHKQKYLQLQQEK----EQELSKLKETVYN----LREENRQLRKAHQDIHTQLQDVKQQ 202
+ K+ +L++ K + + + L+E ++ LRE+ +++RK + + Q + +++Q
Sbjct: 208 LNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQ 267
Query: 203 HKNLLSEHEQL---VVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVT 259
+ + E++ L + + L + ++ E K+L++ ++ + +++ +
Sbjct: 268 EGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMR 327
Query: 260 QVAHSPQGYNTA---REKPTREVQEVSRNND--VWQNHEAVPGRAEDTKLYAPTHKEAEF 314
+ +EK RE ++ R+ + +W+ E + + E + ++ E
Sbjct: 328 EQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEK 387
Query: 315 QAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKE 374
E I++ ++ EE + E+ K ++EE + + E E + PE++++ W++
Sbjct: 388 MQEEERIREREKKMREEEETMREQEEKMQKQEE--NMWEQEEKEWQQQRLPEQKEKLWEQ 445
Query: 375 QHEQREAANLLEGHARA----EVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREH 430
+ Q + + E + E++ K M + + E++ + + ++ Q++ +
Sbjct: 446 EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ 505
Query: 431 QEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDI 490
+E + +Q LR++E++ ++ ++M Q + EE + Q QE+ + +
Sbjct: 506 EERMWEQ---DERLREKEERMRE-QKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEER 561
Query: 491 VQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINP 550
++ E + + EE E++ + Q++ E + REQ + + E +
Sbjct: 562 MREREKKMREEEEMMREQEEKMQEQEE-------KMREQEEKMWEQEEKMQE-------- 606
Query: 551 ADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVD 610
Q E +E+ E++ E+ D+ +EQ++ +QE E+ M +QE+ +
Sbjct: 607 ------QEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMW----EQEEKMR 656
Query: 611 EQYQEEAEEEVQEDLTEEKKRELEHNA---EETYGENDENT---DDKNNDGEEQEVRDDN 664
EQ ++ E+E + EEK RE E EE E +E ++K EE+ +
Sbjct: 657 EQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEE 716
Query: 665 RPKGREEHYEEEEEEEEDGAAVAEK 689
+ G+EE E+EE + + E+
Sbjct: 717 KMWGQEEMREKEERIRDQKEKMQER 741
Score = 83.2 bits (204), Expect = 8e-16
Identities = 108/474 (22%), Positives = 207/474 (43%), Gaps = 77/474 (16%)
Query: 269 NTAREKPTREVQEVSRNNDVWQ---------NHEAVPGRAE-DTKLYAPTHKEAEFQAPP 318
+T +K R ++E+++ D N E AE KL +++E Q
Sbjct: 151 STWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNV 210
Query: 319 EPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQ 378
+ +++++ER + QV+ L+EE Q E L E+ +++++ W+++
Sbjct: 211 KELKRKLERAKFLLPQVQTN---TLQEEMWRQ---EEELREQEKKIRKQEEKMWRQEERL 264
Query: 379 REAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQR 438
RE EG R + + M + + EQ ++ R +++ E ++LRE +E + +Q
Sbjct: 265 REQ----EGKMREQ----EEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQ- 315
Query: 439 LQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQG 498
+ + Q+E+ ++Q + + + +E + + QEQ + + D +++
Sbjct: 316 -EEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEER 374
Query: 499 IQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQG 558
++ +E +E++ + Q+E R RE+ RE E E R E + ++ N
Sbjct: 375 MREQEKMWEQEEKMQEE------ERIREREKKMRE---EEETMREQEEKMQKQEE--NMW 423
Query: 559 EDEFEEAEQVREENLPDENE----EQKQSNQKQENTEVEEHL----VMAGNPD------- 603
E E +E +Q R LP++ E ++K Q+++ E EE + M G
Sbjct: 424 EQEEKEWQQQR---LPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEK 480
Query: 604 --QQEDNVDEQY------------QEEAEEEVQEDLTEEKKRELE-----HNAEETYGEN 644
+QED + EQ QEE E E L E+++R E E+ E
Sbjct: 481 MREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEK 540
Query: 645 DENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEE---EEEDGAAVAEKSHRRAE 695
+K +E+++R++ R + RE+ EEEE E+E+ E+ R E
Sbjct: 541 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQE 594
Score = 72.8 bits (177), Expect = 1e-12
Identities = 78/471 (16%), Positives = 202/471 (42%), Gaps = 62/471 (13%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQK---------ERLEHKKA 85
++Q Q K K ++ +E + Q + ++E ++ + QK E+ E +
Sbjct: 311 QMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLRE 370
Query: 86 KEDFL--VYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQG 143
KE+ + K+ QE + + R + + + ++ Q E+++KQ ++ E+ K+
Sbjct: 371 KEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEW 430
Query: 144 EDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENR------------QLRKAHQD 191
+ + + K+K + ++ +EQE K+ E +R++ ++R+
Sbjct: 431 QQ--QRLPEQKEKLWEQEKMQEQE-EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQ 487
Query: 192 IHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPD 251
+ Q + ++ Q + + + E++ + L + ++ E K++ ++ +K
Sbjct: 488 MWEQEEKMRDQEQKMWDQEERMW----EQDERLREKEERMREQKKMWQQEEKMREEKKTQ 543
Query: 252 PAEQQNVTQVAHSPQGYNTA-REKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHK 310
E++ Q + REK RE +E+ R + + R ++ K++ K
Sbjct: 544 EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEK 603
Query: 311 EAEFQAPPEPIQQEV-ERREPEEHQVEE----EHRKALEEEEMEQVGQAEHLEEEHDPSP 365
E + ++++ E+ E ++ Q +E E + ++E+E + Q E + E+ +
Sbjct: 604 MQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMR 663
Query: 366 EEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQ 425
E++++ ++ + RE EE+++ Q +++ EE
Sbjct: 664 EQEEKMQGQEEKMRE--------------------------QEEKMQGQEEKMREQEEKM 697
Query: 426 QLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQ 476
+ +E + ++++ G + Q++ + E ++ +++E P+H+E+
Sbjct: 698 RGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEER 748
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 115 bits (288), Expect = 1e-25
Identities = 126/669 (18%), Positives = 298/669 (44%), Gaps = 61/669 (9%)
Query: 55 ESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSAL 114
+ L+ +L + L+++L HKKA E L K R AL
Sbjct: 165 KDLAGRLHHSWHFAGELQRALSAVSTRHKKADRYI--------EELTKERD-------AL 209
Query: 115 NVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEK----EQELSK 170
+++ +EELKK++++L+E+ + S + K+ +L++ K + + +
Sbjct: 210 SLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNT 269
Query: 171 LKETVYN----LREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQL---VVTLEDHKSA 223
L+E ++ LRE+ +++RK + + Q + +++Q + + E++ L + +
Sbjct: 270 LQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKE 329
Query: 224 LAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTA---REKPTREVQ 280
L + ++ E K+L++ ++ + +++ + + +EK RE +
Sbjct: 330 LREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE 389
Query: 281 EVSRNND--VWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEE 338
+ R+ + +W+ E + + E + ++ E + +Q++ ++ +E +++EE
Sbjct: 390 QKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEE 449
Query: 339 HR-----KALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEV 393
R K + EEE Q E ++++ + E++++EW++Q + L E E
Sbjct: 450 ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 509
Query: 394 YPSAKPMIKFQSPYEEQLEQQRLAVQQV---EEAQQLREHQEALH--QQRLQGHLLRQQE 448
+ EE Q++ +Q E+ Q+ E +E + +Q++ R ++
Sbjct: 510 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
Query: 449 QQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYER 508
+ Q+Q + + + EE + ++++R++ + +Q E++ + EE +E+
Sbjct: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
Query: 509 DNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQV 568
+ + Q++ E E E+ + + E R + + Q +++ +E E+
Sbjct: 630 EEKMQEQEE----KMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
Query: 569 --REENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLT 626
+E + + +EQ++ QE EE + +++ +E+ E EE++QE
Sbjct: 686 IWEQEKMEKKTQEQEKKTWDQEKMREEESM----REREKKMREEEEMMREQEEKMQEQ-- 739
Query: 627 EEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAV 686
EEK +E E EE + + ++ + + E+Q + P+ +E+ +E E+ +E++
Sbjct: 740 EEKMQEQE---EEMWEQEEKMWEQEEKMWEQQRL-----PEQKEKLWEHEKMQEQEKIWE 791
Query: 687 AEKSHRRAE 695
E+ R E
Sbjct: 792 QEEKMRDQE 800
Score = 115 bits (288), Expect = 1e-25
Identities = 133/691 (19%), Positives = 309/691 (44%), Gaps = 75/691 (10%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQ------------VVYEHRSRLEKSLQKERLEH 82
ELQ +L AE+ + Q + + L +L+ + E R E+ L+++ +
Sbjct: 229 ELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKI 288
Query: 83 KKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQ 142
+K +E + +E K R+ + Q + L+ Q +EL++Q +L E
Sbjct: 289 RKQEEKMWRQEERLREQEGKMREQEEKMWR----QEKRLREQEKELREQEKELRE----- 339
Query: 143 GEDFSRTFNDHKQKYLQLQQEKEQELS-KLKETVYNLREENRQLRKAHQDIHTQLQDVKQ 201
QK L+ Q+E+ QE K+ E +RE+ ++ + + + Q + +++
Sbjct: 340 ------------QKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE 387
Query: 202 QHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQV 261
Q + + + E++ + L + ++ E +++ + + ++ +K E++ Q
Sbjct: 388 QEQKMRDQEERMW----EQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQE 443
Query: 262 AHSPQGYNTA-REKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEP 320
+ REK RE +E R + + ++ ++ KE + Q PE
Sbjct: 444 EKMQEEERIREREKKMREEEETMREQEEKM-------QKQEENMWEQEEKEWQQQRLPEQ 496
Query: 321 IQQ--EVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQ 378
++ E E+ + +E ++ E+ K ++EEM GQ + + + + E++D+ W+++ +
Sbjct: 497 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW--GQEKKMWRQ-EKMREQEDQMWEQEEKM 553
Query: 379 REAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQ- 437
R+ + + + K E+ E++R+ E +++RE +E + +Q
Sbjct: 554 RDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMR----EREKKMREEEEMMREQE 609
Query: 438 -RLQGHLLRQQEQQQQQVAREMALQRQAEL----EEGRPQHQEQLRQQAHYDAMDNDIVQ 492
++Q + QEQ+++ +E +Q Q E EE + +E++ +Q +
Sbjct: 610 EKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLW- 668
Query: 493 GAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPAD 552
E + +Q +E E++ + ++ + + + + ++ +E E E+ R + + +
Sbjct: 669 --EHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEE 726
Query: 553 DPNNQGEDEFEEAE---QVREENLPDENE---EQKQSNQKQENTEVEEHLVMAGNPDQQE 606
+ + E++ +E E Q +EE + ++ E EQ++ +Q+ ++ + Q++
Sbjct: 727 EMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 786
Query: 607 DNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDE--NTDDKNNDGEEQEVRDDN 664
+ + EQ ++ ++E + EEK R E E+ G+ ++ ++K EE+ +
Sbjct: 787 EKIWEQEEKMRDQEEKMRGQEEKMRGQE---EKMRGQEEKMWGQEEKMWGQEEKMWGQEE 843
Query: 665 RPKGREEHYEEEEEEEEDGAAVAEKSHRRAE 695
+ G+EE EE+ + +E+ E+ R E
Sbjct: 844 KMWGQEEKMEEKMQGQEEKMREQEEKMRGQE 874
Score = 104 bits (260), Expect = 2e-22
Identities = 139/722 (19%), Positives = 312/722 (43%), Gaps = 78/722 (10%)
Query: 1 MGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQ 60
+G G K+K+I T G + + + QL++ + + QHQE+L +
Sbjct: 40 VGTGATDTKKKKINHGTNPETTTSGGCHSPEDTQQNRAQLKEEKKAS---HQHQEALRRE 96
Query: 61 LQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYS-ALN---- 115
++ +H R+ + QK LE L Y +A G + S ++ AL+
Sbjct: 97 IEA-QDHTIRI-LTCQKTELETA------LYYSQDAARKFEDGNLGTPSSFNLALSQAFR 148
Query: 116 ------VQHQMLKSQHEEL--KKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQE 167
V ++ + ++L + HS ++ T + +Y++ E +E
Sbjct: 149 GSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRHKKADRYIE---ELTKE 205
Query: 168 LSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAA 227
L +Y N +L+K + ++ +L + + + ++L LE K L
Sbjct: 206 RDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQV 265
Query: 228 QTQVAE---YKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSR 284
QT + ++Q ++ + +RK + + ++ +E RE +E
Sbjct: 266 QTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLRE--------QEGKMREQEE--- 314
Query: 285 NNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALE 344
+W+ + + + ++ + +E E + E +QE + +E EE E+E + +
Sbjct: 315 --KMWRQEKRLREQEKELR-----EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQ 367
Query: 345 EEEM----EQVGQAE-HLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKP 399
EE+M E++ + E + E+ ++++R W++ RE + + +++ +
Sbjct: 368 EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR--EQEKMWEQVEK 425
Query: 400 MIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMA 459
M + + +EQ ++ R ++++E +++RE ++ + ++ +R+QE++ Q+ M
Sbjct: 426 M-REEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEE---ETMREQEEKMQKQEENMW 481
Query: 460 LQRQAELEEGR-PQHQEQLRQQAHYDAMDNDIVQGAE----DQGIQGEEGAYERDNQHQD 514
Q + E ++ R P+ +E+L +Q + I + E + + G+E R + ++
Sbjct: 482 EQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE 541
Query: 515 EAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLP 574
+ + + R+Q + D E ++ E D E++ E E++RE
Sbjct: 542 QEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQ----EEKMREEERMREREKK 597
Query: 575 DENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELE 634
EE+ Q+++ E EE + +QE+ + EQ EE +E +E + E++++ E
Sbjct: 598 MREEEEMMREQEEKMQEQEEKM------QEQEEKMWEQ--EEKMQEQEEKMWEQEEKMWE 649
Query: 635 HNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVAEKSHRRA 694
EE E + K E +++++ + + +EE E+E+ E+ +K+ +
Sbjct: 650 Q--EEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQE 707
Query: 695 EM 696
+M
Sbjct: 708 KM 709
Score = 104 bits (259), Expect = 3e-22
Identities = 118/623 (18%), Positives = 269/623 (43%), Gaps = 63/623 (10%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYK- 93
E + ++RK E + ++ +++ E R EK L+++ E ++ +++ K
Sbjct: 283 EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKE 342
Query: 94 -LEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFND 152
E +E + + + + + Q + + Q E L +Q + E+ +K + R +
Sbjct: 343 LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQ 402
Query: 153 HKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQ 212
++ L+ ++E+ +E K+ E V +REE + Q+ T+ Q+ K Q + + E E+
Sbjct: 403 DER--LREKEERMREQEKMWEQVEKMREEKKM---QEQEKKTRDQEEKMQEEERIREREK 457
Query: 213 LV----VTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKP---DPAEQQNVTQVAHSP 265
+ T+ + + + + + E ++ + R+P ++ Q+ ++
Sbjct: 458 KMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE 517
Query: 266 QGYNTARE------KPTREVQEVSRNNDVWQNHEAVPGRAE-----DTKLYAPTHKEAEF 314
+ E K R+ + + + +W+ E + + + + ++ T ++ +
Sbjct: 518 EKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKK 577
Query: 315 QAPPEPIQQEVER--------REPEEHQVEEEHRKALEEEEMEQVG-----QAEHLEEEH 361
E +E ER RE EE E+E + +EE+M++ Q E ++E+
Sbjct: 578 TWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQE 637
Query: 362 DPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQV 421
+ E++++ W+++ + E L E + + + K Q E+ EQ+++ +
Sbjct: 638 EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQ 697
Query: 422 E------EAQQLREHQ---EALHQQRLQGHLLRQQEQQQQQVAREMALQRQA--ELEEGR 470
E + +++RE + E + R + ++R+QE++ Q+ +M Q + E EE
Sbjct: 698 EQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKM 757
Query: 471 PQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQ- 529
+ +E++ +Q + E + +Q +E +E++ + +D+ E G + R Q
Sbjct: 758 WEQEEKMWEQQRLPEQKEKL---WEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQE 814
Query: 530 ----GPREADPESEADRAAVEDINPADDPNNQGEDE-FEEAEQVREENLPDENE-----E 579
G E E E+ + G++E EE Q +EE + ++ E E
Sbjct: 815 EKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQE 874
Query: 580 QKQSNQKQENTEVEEHLVMAGNP 602
+K Q+++ EE + G+P
Sbjct: 875 EKMREQEEKMRGQEEKIYCVGSP 897
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 113 bits (283), Expect = 5e-25
Identities = 134/648 (20%), Positives = 268/648 (41%), Gaps = 70/648 (10%)
Query: 71 LEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGR--QDSNSRYSALNVQHQM-LKSQHEE 127
L++S+ E+ + + D+L+ ++ + ++ + LN+ H M L S +
Sbjct: 455 LQESVLSEQDLMQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLNSNEKS 514
Query: 128 LKKQHSDLEEEHRKQGE---DFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQ 184
LK +++ + GE D + T ND +Y ++ + KE + K + +
Sbjct: 515 LKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPAT 574
Query: 185 LRKAHQDIHTQLQDVKQQHKNLLSEH-EQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNR 243
+A D ++ + K+ ++ E+ V + + + + E L D L
Sbjct: 575 TIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEI--LSDDLTD 632
Query: 244 IPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTK 303
+ + + ++V + P+G +E S + WQ+ E G + +
Sbjct: 633 KAEVSE---GKAKSVGEAEDGPEGRGDGT------CEEGSSGAEHWQDEEREKGEKDKGR 683
Query: 304 LYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEE-------EEMEQVGQAEH 356
E + P E ++ E+ E ++ EE+ +K E+ +EME+ G+ EH
Sbjct: 684 --------GEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEH 735
Query: 357 LEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRL 416
E E + E++ E + + ++ +EG E K EE+ ++
Sbjct: 736 GEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKK---------EERAGKEEK 786
Query: 417 AVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQR-QAELEEGRPQHQE 475
++ ++ + E E +++ +G + E ++ + RE + + E EEG + +E
Sbjct: 787 GEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEE 846
Query: 476 QLRQQAHYDAMDNDIVQGAE--DQGIQGEEGAYERDNQHQDEAEGD-PGNRHEPREQGPR 532
++ + + + E ++G +GE E + + + E EG+ G E +G
Sbjct: 847 GEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEE 906
Query: 533 EADPESEADRA--------------AVEDINPADDPNNQGEDEFEEAE-QVREENLPDEN 577
E + E E + E+ + + +GE E EE E + EE E
Sbjct: 907 EGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEG 966
Query: 578 EEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQE--EAEEEVQEDLTEEKKRELEH 635
EE+ + ++ E EE G + +E+ +E+ +E E EEE + + EE++ E+E
Sbjct: 967 EEEGEGEGEEGEGEGEEE---EGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEG 1023
Query: 636 NAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDG 683
E GE + ++ +GEE+E +G E EEEEEE+G
Sbjct: 1024 EVEGEEGEGEGEEEEGEEEGEERE----KEGEGEENRRNREEEEEEEG 1067
Score = 94.7 bits (234), Expect = 2e-19
Identities = 101/442 (22%), Positives = 196/442 (44%), Gaps = 59/442 (13%)
Query: 272 REKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPE 331
++K + + E++++ + +N +D+ Y + E +A + + Q + +P
Sbjct: 522 KQKKQQTIGELTQDTALTEN--------DDSDEYEEMSEMKEGKACKQHVSQGIFMTQPA 573
Query: 332 EHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQ-----REAANLLE 386
+A +EE+E + E E+ EEQ+ E E++ + +E +L
Sbjct: 574 TTI------EAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILS 627
Query: 387 GHA--RAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLL 444
+AEV K +S E + + EE EH + +++ +
Sbjct: 628 DDLTDKAEVSEG-----KAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKG 682
Query: 445 RQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEG 504
R + ++ + +E+A + + + +G Q Q++ R+Q H + ++ +G E++ +GEE
Sbjct: 683 RGEMERPGEGEKELAEKEEWKKRDGEEQEQKE-REQGHQKERNQEMEEGGEEEHGEGEEE 741
Query: 505 AYERDNQHQ------DEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQG 558
+R+ + + +E EG+ +E+G R+ + +RA E+ ++ +QG
Sbjct: 742 EGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKE-----ERAGKEE--KGEEEGDQG 794
Query: 559 EDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVD-EQYQEEA 617
E E EE E EE K+E EVE V G +++E+ + E +EE
Sbjct: 795 EGEEEETEGRGEE--------------KEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEG 840
Query: 618 EEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQ----EVRDDNRPKGREEHY 673
E E +E EE++ E + E GE +E ++ +GEE+ E ++ +G EE
Sbjct: 841 EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 900
Query: 674 EEEEEEEEDGAAVAEKSHRRAE 695
E E EEE +G E+ + E
Sbjct: 901 EGEGEEEGEGEGEEEEGEGKGE 922
Score = 62.0 bits (149), Expect = 2e-09
Identities = 70/311 (22%), Positives = 135/311 (43%), Gaps = 33/311 (10%)
Query: 405 SPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQA 464
SP ++Q +QQ + ++ + L E+ ++ + + +++ + +Q V++ + + + A
Sbjct: 518 SPVQKQKKQQTIG--ELTQDTALTENDDSDEYEEMSE--MKEGKACKQHVSQGIFMTQPA 573
Query: 465 ELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEE-------GAYER----DNQHQ 513
E + ++ ++ + ++ G E+Q ++ E G E+ +
Sbjct: 574 TTIEAFSDEEVEIPEEK--EGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLT 631
Query: 514 DEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPA----DDPNNQGEDEFEEAEQVR 569
D+AE G + + G E PE D E + A D+ +GE + E R
Sbjct: 632 DKAEVSEG---KAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMER 688
Query: 570 ----EENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDL 625
E+ L ++ E +K+ ++QE E E+ N + +E +E++ E EEE +
Sbjct: 689 PGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGG-EEEHGEGEEEEGDREE 747
Query: 626 TEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAA 685
EEK+ E EE GE E +K ++E R KG EE ++ E EEE+
Sbjct: 748 EEEKEGE---GKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEG-DQGEGEEEETEG 803
Query: 686 VAEKSHRRAEM 696
E+ E+
Sbjct: 804 RGEEKEEGGEV 814
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 106 bits (265), Expect = 6e-23
Identities = 142/661 (21%), Positives = 291/661 (44%), Gaps = 66/661 (9%)
Query: 52 QHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRY 111
QHQE+L +L+ H R+ + QK L+ V +LE + R + ++
Sbjct: 116 QHQEALRRELEAQV-HTIRI-LTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKF 173
Query: 112 --------SALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQE 163
SA+ Q + EEL K+ L E + + T + K+K +LQ++
Sbjct: 174 AGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN----TITDEELKEKNAKLQEK 229
Query: 164 KEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH--KNLLSEHEQLVVTLEDHK 221
+ S+ E N++E R+L +A + Q + H K L S +L +E+++
Sbjct: 230 LQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENE 289
Query: 222 SALAAAQTQVAEYKQLKDTLN--------RIPSLRKPDPAEQQNVTQVAHSPQGYNTARE 273
Q Q + + ++ + + +R+ + ++ ++ + E
Sbjct: 290 LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEE 349
Query: 274 KPTR------EVQEVSRNND--VWQNHEAVPGRAEDTKLYAPTHKEAEFQAP---PEPIQ 322
K R E +E R + +W+ E + R ++ ++ K E + E I+
Sbjct: 350 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKM--RRQEEMMWEKEEKIRELEEKMHEQEKIR 407
Query: 323 QEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAA 382
++ E+R+ EE E+E R +E+E + Q E + E+ + E++ + W+++ + E
Sbjct: 408 EQEEKRQEEEKIREQEKR---QEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQE 464
Query: 383 NLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQ----R 438
+ E R E + M + + EQ E R + E+ +++R+ +E + +Q R
Sbjct: 465 KIREEEKRQE----QEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIR 520
Query: 439 LQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQL----RQQAHYDAM--DNDIVQ 492
Q +R+QE++ + ++ Q + EE + QE++ ++Q D M + ++
Sbjct: 521 EQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIR 580
Query: 493 GAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPAD 552
E++ + EE E++ + Q++ E + REQ + + E E R E I +
Sbjct: 581 EQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQE-EKIREQEEKIREQE 639
Query: 553 DPNNQGEDEF-EEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDE 611
+ + E++ E+ E++ E+ + +E+ Q+++ E E+ + +QE+ + E
Sbjct: 640 EMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKI------REQEEKIRE 693
Query: 612 QYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREE 671
QEE +E +E + E++++ E EE E +E + EQEVR + + +E
Sbjct: 694 --QEEMMQEQEEKMWEQEEKMCEQ--EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Query: 672 H 672
H
Sbjct: 750 H 750
Score = 82.0 bits (201), Expect = 2e-15
Identities = 85/449 (18%), Positives = 198/449 (44%), Gaps = 44/449 (9%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYE--HRSRLEKSLQKERLEHKKAKEDFLVY 92
++Q Q K K ++ +E + Q ++++E + R ++ + E+ E + +E+ +
Sbjct: 315 KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 374
Query: 93 KLEAQETLNKGRQDSNSRYSALNVQ-HQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFN 151
K E + + + L + H+ K + +E K+Q + E K+ E ++ +
Sbjct: 375 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 434
Query: 152 DHK------------QKYLQLQQEKEQELSKLKETVYNLREEN--RQLRKAH--QDIHTQ 195
+ +K + Q+EK E K++E +E RQ K H ++I Q
Sbjct: 435 QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQ 494
Query: 196 LQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQ 255
+ + +Q + + + E++ E + + Q + + ++ + + + + E+
Sbjct: 495 KEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREE--EK 552
Query: 256 QNVTQVAHSPQGYNTAREKPTREVQEVSRNND-VWQNHEAVPGRAEDTKLYAPTHKEAEF 314
+ + + +K R+ +++ + VW+ E + + E + +E +
Sbjct: 553 MHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQ-----EQEEKM 607
Query: 315 QAPPEPIQQEVERREPEEHQVEEEHRKALEEEEM-----EQVG-QAEHLEEEHDPSPEEQ 368
E I+++ E+ + +E ++ E+ K E+EEM E++G Q E + E+ + E++
Sbjct: 608 WKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQE 667
Query: 369 DREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQ-- 426
+ W+++ + RE E R + + Q E+ EQ+ +Q E+ Q+
Sbjct: 668 ETMWRQEEKIREQ----EKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 723
Query: 427 --LREHQEALHQQRLQGHLLRQQEQQQQQ 453
+R +E + +Q ++ LRQQE++ Q+
Sbjct: 724 EKMRRQEEKMWEQEVR---LRQQEEKMQE 749
Score = 66.2 bits (160), Expect = 1e-10
Identities = 107/514 (20%), Positives = 222/514 (43%), Gaps = 92/514 (17%)
Query: 197 QDVKQQHKNLLSE------HEQLVVTLEDHKSALAAAQTQVAEYKQL----KDTLNRIPS 246
Q QH+ L H ++T + + +A +Q A KQL +D ++R+
Sbjct: 111 QKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHA-VKQLEGEARDLISRLHD 169
Query: 247 LRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYA 306
K +Q ++ VA T ++K R ++E+++ D A +LY
Sbjct: 170 SWKFAGELEQALSAVA-------TQKKKADRYIEELTKERD-----------ALSLELYR 211
Query: 307 PTHKEAEFQAPPEPIQQEVERREPEEHQVE---EEHRKALEEEEMEQVGQAEHLEEEH-D 362
T + E + +Q++++ E E+ +++ +E ++ LE ++ Q E +H
Sbjct: 212 NTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 271
Query: 363 PSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVE 422
+ + + Q E+ E N L +++ EE++++ +Q+ E
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ-----------EEKIQEWEEKIQEQE 320
Query: 423 EAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAH 482
E ++RE +E + +Q + +R+QE+ + +E ++RQ EE + +E++R+Q
Sbjct: 321 E--KIREQEEKIREQEEK---MRRQEEMMWE--KEEKMRRQ---EEMMWEKEEKMRRQ-- 368
Query: 483 YDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADR 542
+++ E++ + EE +E++ + ++ E HE +E E E R
Sbjct: 369 -----EEMMWEKEEKMRRQEEMMWEKEEKIRELEE----KMHE------QEKIREQEEKR 413
Query: 543 AAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNP 602
Q E++ E E+ +E+ +E+K Q+++ E E+ +
Sbjct: 414 --------------QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMW----- 454
Query: 603 DQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRD 662
+QE+ + EQ + EE+ QE ++ E H EE + + ++ + + +++E
Sbjct: 455 -RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVW 513
Query: 663 DNRPKGREEHYEEEEEEEEDGAAVAEKSHRRAEM 696
K RE+ E+ E+EE EK + EM
Sbjct: 514 RQEEKIREQE-EKIREQEEKMWRQEEKIREQEEM 546
Score = 57.8 bits (138), Expect = 3e-08
Identities = 95/427 (22%), Positives = 169/427 (39%), Gaps = 59/427 (13%)
Query: 290 QNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEME 349
Q + +V A DTK K+ PE +E + +H++AL E
Sbjct: 73 QTNPSVGTAASDTK-----KKKINNGTNPETTTSGGCHSPEDEQKASHQHQEALRRELEA 127
Query: 350 QVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEE 409
QV L + E Q + QH A LEG AR ++ KF E+
Sbjct: 128 QVHTIRILTCQ---KTELQMALYYSQH----AVKQLEGEAR-DLISRLHDSWKFAGELEQ 179
Query: 410 QLE----QQRLAVQQVEEAQQLRE------HQEALHQQRLQGHLLRQQEQQQQQVAREMA 459
L Q++ A + +EE + R+ ++ + + L+ + QE+ Q + +
Sbjct: 180 ALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSE 239
Query: 460 LQRQAE-----LEEGR---PQHQEQ----------------LRQQAHYDAMDNDIVQGAE 495
+Q + LE + PQ Q Q L+ Q + + N + Q E
Sbjct: 240 IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQE 299
Query: 496 DQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPN 555
++ + EE E + + Q++ E + REQ + + E + R +
Sbjct: 300 EKMWRQEEKIQEWEEKIQEQEE-------KIREQEEKIREQEEKMRRQEEMMWEKEEKMR 352
Query: 556 NQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQE 615
Q E +E+ E++R + +E+K Q++ E EE + +++ + EQ ++
Sbjct: 353 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 412
Query: 616 EAEEEVQEDLTEEKKRELEHNA---EETYGENDENTDDKNNDGEEQEVRDDNRPKGREEH 672
EEE + +EK++E E EE E +E ++ QE + + K REE
Sbjct: 413 RQEEEKIRE--QEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEE 470
Query: 673 YEEEEEE 679
+E+EE
Sbjct: 471 KRQEQEE 477
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 95.5 bits (236), Expect = 1e-19
Identities = 159/750 (21%), Positives = 313/750 (41%), Gaps = 111/750 (14%)
Query: 39 QLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERL-EHKKAKEDFLVYKL--- 94
Q R+ E A +++ E AQL+ + +K L ++ L + ++ +E+ L K
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935
Query: 95 -----EAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRT 149
+A+ L GR SN+ + + + L++ + +Q + EE R++ E+ +
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ---RQLAAEEERRRREAEERVQK 1992
Query: 150 FNDHKQKYLQLQQEKEQELSKLKETVYNLR--------EENRQLRKAHQDIHTQLQDVKQ 201
+++ + ++ +E+ +LK V R E RQL+ A + +LQ ++
Sbjct: 1993 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2052
Query: 202 QHKNLLSEHEQ-LVVTLEDHKSAL---------AAAQTQVAEYKQLKDTLNRIPSLRKPD 251
H + + EQ L TL+ +S L A + AE +++ S R+ +
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2112
Query: 252 PAEQ--QNVTQVAHSPQGYNTAREKPTREV-QEVSRNNDVWQ----NHEAVPGRAEDTKL 304
AE+ Q+ + A + A EK +E QE +R Q +A E K
Sbjct: 2113 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2172
Query: 305 YAPT--HKEAEFQAPPEPIQQEVERREPEEHQVEEE-------------HRKALEEE--- 346
+A ++A+ + ++ ++E + +++ ++EE R +EEE
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 347 ---EMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLE-GHARAEVYPSAKPMIK 402
+ME++ + + E + + +D++ ++ Q EA + + A + +A+ +
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292
Query: 403 FQSPYEEQLEQQRLA--------VQQVEEAQQLREHQEALHQQR-LQGHLLRQQEQQQQQ 453
+ EE L QQR +Q V+EA +L+ E L QQ+ L R+ ++ ++Q
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 454 VAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQ 513
+A+++A + Q + Q QL A + + + + + Q E+ R Q
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK---Q 2409
Query: 514 DEAEGDPGNRHEPREQGP-----------READPESEADRAAVEDINPADDPNNQGED-- 560
E G+ +R E Q +++D ++E R A+ ++ + Q
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 561 --EFEEAEQVREENLPDENEEQKQS--NQK-----------QENTEVEEHLVMAGNPDQQ 605
+ EE + V++E L E + +QS ++K QE ++E+ QQ
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2529
Query: 606 EDNVDEQYQEEAEEEVQEDLTE-EKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDN 664
++ Q++ E+E Q + E+ R +H AEE E E Q++
Sbjct: 2530 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---------ELQQLEQQR 2580
Query: 665 RPKGREEHYEEEEEEEEDGAAVAEKSHRRA 694
R +EE EE + + + E+ HR A
Sbjct: 2581 RQ--QEELLAEENQRLREQLQLLEEQHRAA 2608
Score = 86.3 bits (212), Expect = 9e-17
Identities = 117/482 (24%), Positives = 214/482 (44%), Gaps = 65/482 (13%)
Query: 35 ELQTQLR-KAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYK 93
E Q Q R +A+A A K ++ E +A+ + R +++ E +HKK E L K
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181
Query: 94 LEAQETLNKGR---QDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEH---RKQGEDFS 147
+ ++ L R ++++ + + L+ + Q LK++ E +Q S +EEE R Q E+ S
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241
Query: 148 RTF--------------NDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIH 193
+ D+ Q++LQ + EK +++++ + +E +LR+ ++
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2299
Query: 194 TQLQDVKQQH---KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKP 250
D+ QQ + +L E Q V + L A + + K+L R+
Sbjct: 2300 ----DLAQQRALAEKMLKEKMQAV----QEATRLKAEAELLQQQKELAQE-----QARRL 2346
Query: 251 DPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHK 310
++Q Q+A QG+ E + E+S + + A RA+ A +
Sbjct: 2347 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ-----ARAEE 2401
Query: 311 EAE-FQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEE---EHDPSPE 366
+A+ F+ E I +++ R E Q + + LE + + AE L E E + E
Sbjct: 2402 DAQRFRKQAEEIGEKLHRTELAT-QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2460
Query: 367 EQDREWK-------EQHEQREAANLLEGHARAEVYPSAKPMIKFQSPY--EEQLEQQRLA 417
+ +E K E ++ L E A + + S K + + + +E+ + ++L
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520
Query: 418 VQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQL 477
+V +AQQLRE Q+ QQ +QE+Q+ + E A +RQ E EEG + QE+L
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQM-------EQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2573
Query: 478 RQ 479
+Q
Sbjct: 2574 QQ 2575
Score = 80.5 bits (197), Expect = 5e-15
Identities = 154/754 (20%), Positives = 291/754 (38%), Gaps = 110/754 (14%)
Query: 35 ELQTQLRKAEAVA---LKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLV 91
E+Q + R+AEA L+ ++ + QL+ R E LQ R ++A+
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 92 YKLEAQETLNKGRQDSNSRYSALNVQ-HQMLKSQHEELKKQHSDLE--EEHRKQGEDFSR 148
+ EA E L + QD + R V+ +K++ E +++ L+ EE R Q E+ R
Sbjct: 1492 AQEEA-ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1550
Query: 149 TFNDH-----KQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
+Q + L+ + ++L+ + E+ QL ++ Q+ H + ++++
Sbjct: 1551 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1610
Query: 204 KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH 263
+ + + E+ + L Q + E +L+ L+ + A+Q+++ Q
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLR--------LQAEEVAQQKSLAQAEA 1662
Query: 264 SPQGYNTARE----------------------KPTREVQEVSRNNDVWQNHEAVPGRAE- 300
Q RE + R++ E + + E + RAE
Sbjct: 1663 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1722
Query: 301 -----------------DTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKAL 343
+ A T K E +A ++ E+E + + EEE R
Sbjct: 1723 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1782
Query: 344 EEEEME---QVGQAEHLEEEHD-----PSPEEQDREWKEQHEQREAANLLEGHARAEVYP 395
E+ + + G+ L EE ++ R+ E+ R+ A A
Sbjct: 1783 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842
Query: 396 SAKPMIKFQSPY---EEQLEQQRLAVQQVEEAQQLR--EHQEALHQQRLQGHLLRQQEQQ 450
+K ++ E++ E +RL +EA Q R E Q A H+ ++ L + ++
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1902
Query: 451 QQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMD----------NDIVQGAEDQGIQ 500
++ R+ L L + R +E L +A ++ I AED
Sbjct: 1903 DSELERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 501 GEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADR---AAVEDINPADDPNNQ 557
E+ E Q Q AE + R E E+ + E EA R AA+E++
Sbjct: 1962 KEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEVERL------ 2014
Query: 558 GEDEFEEAEQVREENLPDENEE---QKQSNQKQENTEVEEHLVMAGNPD-------QQED 607
+ + EEA ++RE + + +++ QK+ E + H + QQE
Sbjct: 2015 -KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2073
Query: 608 NVDEQYQEEAEEEVQ-EDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRP 666
+V +Q + EAE + + EE + + E A ++ + +E K + E+ + R +
Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2133
Query: 667 KGREEHYEEEEE----EEEDGAAVAEKSHRRAEM 696
+ E E+E + + AA+ +K AEM
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2167
Score = 76.3 bits (186), Expect = 9e-14
Identities = 139/679 (20%), Positives = 259/679 (38%), Gaps = 61/679 (8%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRL---------EKSLQKERLEHKKA 85
E + Q + AE A + + E + A+ +RL EK + ERL
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1871
Query: 86 KEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEE--EHRKQG 143
E F +LE Q +K D R + Q+ K+ EL++Q +E+ R+Q
Sbjct: 1872 DEAFQRRRLEEQAAQHKA--DIEERLA------QLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 144 EDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
E+ +K + E E EL +++ N + R +A + Q Q ++
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRS---NAEDTLRSKEQAELEAARQRQLAAEEE 1980
Query: 204 KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH 263
+ E++ +L + A + + E ++LK + LR+ E Q+A
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040
Query: 264 SPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQ 323
E+ + ++ Q + + + A + A +A +Q
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2100
Query: 324 EVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAAN 383
E E + E E K EE+ + QA+ E+ +E ++E + + +AA
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK---LRKEAEQEAARRAQAEQAAL 2157
Query: 384 LLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLR-EHQEALHQQRLQGH 442
+ A AE+ K + EQ +Q+ V+Q E LR + +E HQ+ L
Sbjct: 2158 RQKQAADAEMEKHKK--------FAEQTLRQKAQVEQ--ELTTLRLQLEETDHQKNLLDE 2207
Query: 443 LLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGE 502
L++ + + + AR+ + Q + EL R Q +E + +A +A + ++ +D +
Sbjct: 2208 ELQRLKAEATEAARQRS-QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266
Query: 503 EGAYERDNQHQDE-----------------AEGDPGNRHEPREQGPRE-ADPESEADRAA 544
+ E+ Q +E AE D + E+ +E EA R
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2326
Query: 545 VEDINPADDPNNQGEDEFEEAEQVRE--ENLPDENEEQKQSNQKQENTEVEEHLVMAGNP 602
E A+ Q E E+A +++E E + + E+ Q Q+ E + L M+
Sbjct: 2327 AE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382
Query: 603 DQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRD 662
++ + V E + +A E ++ E+ T E +++ D
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442
Query: 663 DNRPKGREEHYEEEEEEEE 681
+ + RE E E E+E+
Sbjct: 2443 HDAERLREAIAELEREKEK 2461
Score = 71.6 bits (174), Expect = 2e-12
Identities = 97/435 (22%), Positives = 185/435 (42%), Gaps = 38/435 (8%)
Query: 31 MLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKER----LEHKKAK 86
+L ELQ +A A + Q +E L + ++V E S+L+ ++ E L K
Sbjct: 2204 LLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKLKARIEAENRALILRDKDNT 2262
Query: 87 EDFLVYKLEAQETLNKGRQ--DSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGE 144
+ FL QE K +Q + +R S + L+ EE Q L E+ K+
Sbjct: 2263 QRFL------QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316
Query: 145 DFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHK 204
+ K + LQQ+KE + + + + +QL + Q L+ +Q+
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 205 NLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH- 263
+ +E E+L + + + A A A+ +++ + + L + + A Q+ VT V
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE--KLHRTELATQEKVTLVQTL 2434
Query: 264 --SPQGYNTAREKPTREVQEVSRNND-VWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEP 320
Q + E+ + E+ R + + Q + + ++E+ + E QA +
Sbjct: 2435 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2494
Query: 321 IQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQRE 380
E + E +E+E K LE+ ++V +A+ L EE +++ ++ EQ QR
Sbjct: 2495 FLSEKDSLLQRERFIEQEKAK-LEQLFQDEVAKAQQLREE-----QQRQQQQMEQERQRL 2548
Query: 381 AANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQ 440
A++ E R Q EE + +++ +QQ+E+ ++ +E A QRL+
Sbjct: 2549 VASMEEARRR-------------QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595
Query: 441 GHLLRQQEQQQQQVA 455
L +EQ + +A
Sbjct: 2596 EQLQLLEEQHRAALA 2610
Score = 64.3 bits (155), Expect = 4e-10
Identities = 154/727 (21%), Positives = 293/727 (40%), Gaps = 103/727 (14%)
Query: 43 AEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDF----LVYKLEAQE 98
A++ A++ Q QE A L+ + H ++E+ Q+ ++ A +D+ + YK + +
Sbjct: 1239 ADSQAVREQLRQEQ--ALLEEIERHGEKVEEC-QRFAKQYINAIKDYELQLVTYKAQLEP 1295
Query: 99 TLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYL 158
+ ++ S +Q ++ +L+ +S+L + + S T +++
Sbjct: 1296 VASPAKKPKVQSGSESVIQ------EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 159 QLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQ--------------------- 197
+Q++ +E +L E L E+ RQL +AH Q +
Sbjct: 1350 LAEQQRAEERERLAEVEAAL-EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408
Query: 198 -DVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLK-DTLNRIPSL------RK 249
D +QQ +++ E +QL + E A A Q + AE +L+ + R+ L R+
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQA-KARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467
Query: 250 PDPAEQQNVTQVAHSPQGYNTAR------EKPTREVQEVSRNNDVWQ-------NHEAVP 296
AE + A + + R E+ R+VQ+ S+ + EA
Sbjct: 1468 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1527
Query: 297 GRAEDTKLYAPTHKEAEFQAPPEPIQQ-EVERREPEEHQVEEEHRKALEEEEMEQVGQAE 355
R + L A + + ++Q EVER + +E R A E + ++ AE
Sbjct: 1528 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587
Query: 356 H-------LEEEHDPSPEEQDREWKEQHEQREAANLLEGHARA--EVYPSAKPMIKFQSP 406
L+EEH + ++ + +Q EA E R A ++ +
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Query: 407 YEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAEL 466
EE +Q+ LA + E+ ++ E +EA + + + +RQ+E +Q+ L++Q +L
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAE-REARRRGKAEEQAVRQRELAEQE------LEKQRQL 1700
Query: 467 EEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGA-YERD----NQHQDEAEGDPG 521
EG Q++L + + + QG + + + EE A +R+ Q + E E +
Sbjct: 1701 AEGTA--QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758
Query: 522 N-RHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQ 580
R E +A E E+ + + + + + EEA ++R L +E + Q
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA--LAEEAKRQ 1816
Query: 581 KQ------SNQKQENTEV-EEHLVMAGNPDQQEDNVDEQYQE-EAEEEVQEDLTEE---K 629
+Q + Q+ E V E L G + + + +E EAE E L E+ +
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 630 KRELEHNAEETYGENDENTDD--KNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVA 687
+R LE A + + +E K +D E + R KG E + + E+
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELE------RQKGLVEDTLRQRRQVEEEILAL 1930
Query: 688 EKSHRRA 694
+ S +A
Sbjct: 1931 KASFEKA 1937
Score = 59.7 bits (143), Expect = 9e-09
Identities = 132/632 (20%), Positives = 240/632 (37%), Gaps = 106/632 (16%)
Query: 142 QGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQ 201
QG + ++ + K Q EL K ++ LR + + + +L+ ++
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158
Query: 202 QHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQV 261
+ L H + V +E + +A L R ++ Q+ + Q+
Sbjct: 1159 VGERLQQRHGERDVEVERWRERVA-------------QLLERWQAVLAQTDVRQRELEQL 1205
Query: 262 AHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPI 321
+ Y + + +Q+ R + Q +A +L + QA E I
Sbjct: 1206 GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-------RQEQALLEEI 1258
Query: 322 QQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREA 381
++ E+ E E + +++ A+++ E++ V LE P+ + + + E Q E
Sbjct: 1259 ERHGEKVE-ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EY 1316
Query: 382 ANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQ-RLAVQQ-VEEAQQLREHQEALH---- 435
+L ++ E+ IKF S ++E++ RLA QQ EE ++L E + AL
Sbjct: 1317 VDLRTHYS--ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1374
Query: 436 -------------------QQRLQGHLLRQQE------QQQQQVAREM------------ 458
QQR+Q ++R++E QQ++ + E+
Sbjct: 1375 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1434
Query: 459 ALQRQAE-LEEGRPQHQEQLR--------QQAHYDAMDNDI------VQGAEDQGIQGEE 503
A RQAE E R + +E++R + + ++ + AE Q Q +E
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1494
Query: 504 GAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRA--AVEDI----NPADDPNNQ 557
A Q QDE++ E + EA+ E RA A+E++ A+ Q
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1554
Query: 558 GEDE--------FEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNV 609
E E E A++ E L + + + E + EEH+ +A ++ E
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1614
Query: 610 DEQYQ-----EEAEEEVQE-DLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDD 663
+Q + EEAE E++ L + L AEE + + EE E
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1674
Query: 664 NRPKGREEHYEEEEEEEEDGAAVAEKSHRRAE 695
R K E+ + E E++ EK + AE
Sbjct: 1675 RRGKAEEQAVRQRELAEQE----LEKQRQLAE 1702
Score = 54.7 bits (130), Expect = 3e-07
Identities = 79/346 (22%), Positives = 147/346 (42%), Gaps = 54/346 (15%)
Query: 42 KAEAV--ALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQET 99
K +AV A + + E L Q ++ E RL++ KE++ + A+E Q T
Sbjct: 2315 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQED--KEQMAQQLAEET-----QGFQRT 2367
Query: 100 LNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEE---HRKQ----GEDFSRTFND 152
L RQ R ++ + + LK + E+ + + EE+ RKQ GE RT
Sbjct: 2368 LEAERQ----RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423
Query: 153 HKQKYLQLQ------QEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQ-QHKN 205
++K +Q Q+ + + +L+E + L E +L++ + + + ++++ Q +
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2483
Query: 206 LLSEHEQLVVTLEDHKSALAAAQTQVAEYKQ-----LKDTLNRIPSLRKPDPAEQQNVTQ 260
LL E + L + K +L + + + K +D + + LR+ +QQ + Q
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 261 VAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPG-RAEDTKLYAPTHKEAEFQAPPE 319
R++ ++E R + HEA G R + +L E + + E
Sbjct: 2544 ----------ERQRLVASMEEARR-----RQHEAEEGVRRKQEELQ---QLEQQRRQQEE 2585
Query: 320 PIQQEVERREPEEHQVEEEHRKAL---EEEEMEQVGQAEHLEEEHD 362
+ +E +R + +EE+HR AL EE QV + L D
Sbjct: 2586 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2631
Score = 50.8 bits (120), Expect = 4e-06
Identities = 64/262 (24%), Positives = 118/262 (45%), Gaps = 41/262 (15%)
Query: 30 AMLYYELQTQLRKAEAVALKYQQ----HQESLSAQLQVVYEH-RSRLEKSLQKER-LEHK 83
A L E + ++A+ + LK ++ QE L + Q + + S + LQ+ER +E +
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2512
Query: 84 KAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQG 143
KAK + L A+ + R++ + + + Q L + EE +++ + EE R++
Sbjct: 2513 KAKLEQLFQDEVAKA--QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570
Query: 144 EDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
E+ QL+Q++ Q+ L EEN++LR+ QLQ +++QH
Sbjct: 2571 EELQ-----------QLEQQRRQQEEL-------LAEENQRLRE-------QLQLLEEQH 2605
Query: 204 KNLLSEHEQLVV-------TLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQ 256
+ L+ E++ TL + + AL + AE + D L R S ++ A
Sbjct: 2606 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAE-AEPEHSFDGLRRKVSAQRLQEAGIL 2664
Query: 257 NVTQVAHSPQGYNTAREKPTRE 278
+ ++ QG+ T E RE
Sbjct: 2665 SAEELQRLAQGHTTVDELARRE 2686
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 95.5 bits (236), Expect = 1e-19
Identities = 159/750 (21%), Positives = 313/750 (41%), Gaps = 111/750 (14%)
Query: 39 QLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERL-EHKKAKEDFLVYKL--- 94
Q R+ E A +++ E AQL+ + +K L ++ L + ++ +E+ L K
Sbjct: 1880 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1939
Query: 95 -----EAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRT 149
+A+ L GR SN+ + + + L++ + +Q + EE R++ E+ +
Sbjct: 1940 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ---RQLAAEEERRRREAEERVQK 1996
Query: 150 FNDHKQKYLQLQQEKEQELSKLKETVYNLR--------EENRQLRKAHQDIHTQLQDVKQ 201
+++ + ++ +E+ +LK V R E RQL+ A + +LQ ++
Sbjct: 1997 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2056
Query: 202 QHKNLLSEHEQ-LVVTLEDHKSAL---------AAAQTQVAEYKQLKDTLNRIPSLRKPD 251
H + + EQ L TL+ +S L A + AE +++ S R+ +
Sbjct: 2057 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2116
Query: 252 PAEQ--QNVTQVAHSPQGYNTAREKPTREV-QEVSRNNDVWQ----NHEAVPGRAEDTKL 304
AE+ Q+ + A + A EK +E QE +R Q +A E K
Sbjct: 2117 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2176
Query: 305 YAPT--HKEAEFQAPPEPIQQEVERREPEEHQVEEE-------------HRKALEEE--- 346
+A ++A+ + ++ ++E + +++ ++EE R +EEE
Sbjct: 2177 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2236
Query: 347 ---EMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLE-GHARAEVYPSAKPMIK 402
+ME++ + + E + + +D++ ++ Q EA + + A + +A+ +
Sbjct: 2237 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2296
Query: 403 FQSPYEEQLEQQRLA--------VQQVEEAQQLREHQEALHQQR-LQGHLLRQQEQQQQQ 453
+ EE L QQR +Q V+EA +L+ E L QQ+ L R+ ++ ++Q
Sbjct: 2297 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2356
Query: 454 VAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQ 513
+A+++A + Q + Q QL A + + + + + Q E+ R Q
Sbjct: 2357 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK---Q 2413
Query: 514 DEAEGDPGNRHEPREQGP-----------READPESEADRAAVEDINPADDPNNQGED-- 560
E G+ +R E Q +++D ++E R A+ ++ + Q
Sbjct: 2414 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2473
Query: 561 --EFEEAEQVREENLPDENEEQKQS--NQK-----------QENTEVEEHLVMAGNPDQQ 605
+ EE + V++E L E + +QS ++K QE ++E+ QQ
Sbjct: 2474 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2533
Query: 606 EDNVDEQYQEEAEEEVQEDLTE-EKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDN 664
++ Q++ E+E Q + E+ R +H AEE E E Q++
Sbjct: 2534 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---------ELQQLEQQR 2584
Query: 665 RPKGREEHYEEEEEEEEDGAAVAEKSHRRA 694
R +EE EE + + + E+ HR A
Sbjct: 2585 RQ--QEELLAEENQRLREQLQLLEEQHRAA 2612
Score = 86.3 bits (212), Expect = 9e-17
Identities = 117/482 (24%), Positives = 214/482 (44%), Gaps = 65/482 (13%)
Query: 35 ELQTQLR-KAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYK 93
E Q Q R +A+A A K ++ E +A+ + R +++ E +HKK E L K
Sbjct: 2126 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2185
Query: 94 LEAQETLNKGR---QDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEH---RKQGEDFS 147
+ ++ L R ++++ + + L+ + Q LK++ E +Q S +EEE R Q E+ S
Sbjct: 2186 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2245
Query: 148 RTF--------------NDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIH 193
+ D+ Q++LQ + EK +++++ + +E +LR+ ++
Sbjct: 2246 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2303
Query: 194 TQLQDVKQQH---KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKP 250
D+ QQ + +L E Q V + L A + + K+L R+
Sbjct: 2304 ----DLAQQRALAEKMLKEKMQAV----QEATRLKAEAELLQQQKELAQE-----QARRL 2350
Query: 251 DPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHK 310
++Q Q+A QG+ E + E+S + + A RA+ A +
Sbjct: 2351 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ-----ARAEE 2405
Query: 311 EAE-FQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEE---EHDPSPE 366
+A+ F+ E I +++ R E Q + + LE + + AE L E E + E
Sbjct: 2406 DAQRFRKQAEEIGEKLHRTELAT-QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2464
Query: 367 EQDREWK-------EQHEQREAANLLEGHARAEVYPSAKPMIKFQSPY--EEQLEQQRLA 417
+ +E K E ++ L E A + + S K + + + +E+ + ++L
Sbjct: 2465 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2524
Query: 418 VQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQL 477
+V +AQQLRE Q+ QQ +QE+Q+ + E A +RQ E EEG + QE+L
Sbjct: 2525 QDEVAKAQQLREEQQRQQQQM-------EQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2577
Query: 478 RQ 479
+Q
Sbjct: 2578 QQ 2579
Score = 80.5 bits (197), Expect = 5e-15
Identities = 154/754 (20%), Positives = 291/754 (38%), Gaps = 110/754 (14%)
Query: 35 ELQTQLRKAEAVA---LKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLV 91
E+Q + R+AEA L+ ++ + QL+ R E LQ R ++A+
Sbjct: 1436 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1495
Query: 92 YKLEAQETLNKGRQDSNSRYSALNVQ-HQMLKSQHEELKKQHSDLE--EEHRKQGEDFSR 148
+ EA E L + QD + R V+ +K++ E +++ L+ EE R Q E+ R
Sbjct: 1496 AQEEA-ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1554
Query: 149 TFNDH-----KQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
+Q + L+ + ++L+ + E+ QL ++ Q+ H + ++++
Sbjct: 1555 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1614
Query: 204 KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH 263
+ + + E+ + L Q + E +L+ L+ + A+Q+++ Q
Sbjct: 1615 ERRAQQQAEAERAREEAERELERWQLKANEALRLR--------LQAEEVAQQKSLAQAEA 1666
Query: 264 SPQGYNTARE----------------------KPTREVQEVSRNNDVWQNHEAVPGRAE- 300
Q RE + R++ E + + E + RAE
Sbjct: 1667 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1726
Query: 301 -----------------DTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKAL 343
+ A T K E +A ++ E+E + + EEE R
Sbjct: 1727 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1786
Query: 344 EEEEME---QVGQAEHLEEEHD-----PSPEEQDREWKEQHEQREAANLLEGHARAEVYP 395
E+ + + G+ L EE ++ R+ E+ R+ A A
Sbjct: 1787 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1846
Query: 396 SAKPMIKFQSPY---EEQLEQQRLAVQQVEEAQQLR--EHQEALHQQRLQGHLLRQQEQQ 450
+K ++ E++ E +RL +EA Q R E Q A H+ ++ L + ++
Sbjct: 1847 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1906
Query: 451 QQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMD----------NDIVQGAEDQGIQ 500
++ R+ L L + R +E L +A ++ I AED
Sbjct: 1907 DSELERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1965
Query: 501 GEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADR---AAVEDINPADDPNNQ 557
E+ E Q Q AE + R E E+ + E EA R AA+E++
Sbjct: 1966 KEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEVERL------ 2018
Query: 558 GEDEFEEAEQVREENLPDENEE---QKQSNQKQENTEVEEHLVMAGNPD-------QQED 607
+ + EEA ++RE + + +++ QK+ E + H + QQE
Sbjct: 2019 -KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2077
Query: 608 NVDEQYQEEAEEEVQ-EDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRP 666
+V +Q + EAE + + EE + + E A ++ + +E K + E+ + R +
Sbjct: 2078 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2137
Query: 667 KGREEHYEEEEE----EEEDGAAVAEKSHRRAEM 696
+ E E+E + + AA+ +K AEM
Sbjct: 2138 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2171
Score = 76.3 bits (186), Expect = 9e-14
Identities = 139/679 (20%), Positives = 259/679 (38%), Gaps = 61/679 (8%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRL---------EKSLQKERLEHKKA 85
E + Q + AE A + + E + A+ +RL EK + ERL
Sbjct: 1816 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1875
Query: 86 KEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEE--EHRKQG 143
E F +LE Q +K D R + Q+ K+ EL++Q +E+ R+Q
Sbjct: 1876 DEAFQRRRLEEQAAQHKA--DIEERLA------QLRKASDSELERQKGLVEDTLRQRRQV 1927
Query: 144 EDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
E+ +K + E E EL +++ N + R +A + Q Q ++
Sbjct: 1928 EEEILALKASFEKAAAGKAELELELGRIRS---NAEDTLRSKEQAELEAARQRQLAAEEE 1984
Query: 204 KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH 263
+ E++ +L + A + + E ++LK + LR+ E Q+A
Sbjct: 1985 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2044
Query: 264 SPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQ 323
E+ + ++ Q + + + A + A +A +Q
Sbjct: 2045 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2104
Query: 324 EVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAAN 383
E E + E E K EE+ + QA+ E+ +E ++E + + +AA
Sbjct: 2105 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK---LRKEAEQEAARRAQAEQAAL 2161
Query: 384 LLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLR-EHQEALHQQRLQGH 442
+ A AE+ K + EQ +Q+ V+Q E LR + +E HQ+ L
Sbjct: 2162 RQKQAADAEMEKHKK--------FAEQTLRQKAQVEQ--ELTTLRLQLEETDHQKNLLDE 2211
Query: 443 LLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGE 502
L++ + + + AR+ + Q + EL R Q +E + +A +A + ++ +D +
Sbjct: 2212 ELQRLKAEATEAARQRS-QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2270
Query: 503 EGAYERDNQHQDE-----------------AEGDPGNRHEPREQGPRE-ADPESEADRAA 544
+ E+ Q +E AE D + E+ +E EA R
Sbjct: 2271 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2330
Query: 545 VEDINPADDPNNQGEDEFEEAEQVRE--ENLPDENEEQKQSNQKQENTEVEEHLVMAGNP 602
E A+ Q E E+A +++E E + + E+ Q Q+ E + L M+
Sbjct: 2331 AE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2386
Query: 603 DQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRD 662
++ + V E + +A E ++ E+ T E +++ D
Sbjct: 2387 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2446
Query: 663 DNRPKGREEHYEEEEEEEE 681
+ + RE E E E+E+
Sbjct: 2447 HDAERLREAIAELEREKEK 2465
Score = 71.6 bits (174), Expect = 2e-12
Identities = 97/435 (22%), Positives = 185/435 (42%), Gaps = 38/435 (8%)
Query: 31 MLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKER----LEHKKAK 86
+L ELQ +A A + Q +E L + ++V E S+L+ ++ E L K
Sbjct: 2208 LLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKLKARIEAENRALILRDKDNT 2266
Query: 87 EDFLVYKLEAQETLNKGRQ--DSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGE 144
+ FL QE K +Q + +R S + L+ EE Q L E+ K+
Sbjct: 2267 QRFL------QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2320
Query: 145 DFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHK 204
+ K + LQQ+KE + + + + +QL + Q L+ +Q+
Sbjct: 2321 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2380
Query: 205 NLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH- 263
+ +E E+L + + + A A A+ +++ + + L + + A Q+ VT V
Sbjct: 2381 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE--KLHRTELATQEKVTLVQTL 2438
Query: 264 --SPQGYNTAREKPTREVQEVSRNND-VWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEP 320
Q + E+ + E+ R + + Q + + ++E+ + E QA +
Sbjct: 2439 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2498
Query: 321 IQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQRE 380
E + E +E+E K LE+ ++V +A+ L EE +++ ++ EQ QR
Sbjct: 2499 FLSEKDSLLQRERFIEQEKAK-LEQLFQDEVAKAQQLREE-----QQRQQQQMEQERQRL 2552
Query: 381 AANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQ 440
A++ E R Q EE + +++ +QQ+E+ ++ +E A QRL+
Sbjct: 2553 VASMEEARRR-------------QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2599
Query: 441 GHLLRQQEQQQQQVA 455
L +EQ + +A
Sbjct: 2600 EQLQLLEEQHRAALA 2614
Score = 64.3 bits (155), Expect = 4e-10
Identities = 154/727 (21%), Positives = 293/727 (40%), Gaps = 103/727 (14%)
Query: 43 AEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDF----LVYKLEAQE 98
A++ A++ Q QE A L+ + H ++E+ Q+ ++ A +D+ + YK + +
Sbjct: 1243 ADSQAVREQLRQEQ--ALLEEIERHGEKVEEC-QRFAKQYINAIKDYELQLVTYKAQLEP 1299
Query: 99 TLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYL 158
+ ++ S +Q ++ +L+ +S+L + + S T +++
Sbjct: 1300 VASPAKKPKVQSGSESVIQ------EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1353
Query: 159 QLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQ--------------------- 197
+Q++ +E +L E L E+ RQL +AH Q +
Sbjct: 1354 LAEQQRAEERERLAEVEAAL-EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1412
Query: 198 -DVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLK-DTLNRIPSL------RK 249
D +QQ +++ E +QL + E A A Q + AE +L+ + R+ L R+
Sbjct: 1413 VDAQQQKRSIQEELQQLRQSSEAEIQA-KARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1471
Query: 250 PDPAEQQNVTQVAHSPQGYNTAR------EKPTREVQEVSRNNDVWQ-------NHEAVP 296
AE + A + + R E+ R+VQ+ S+ + EA
Sbjct: 1472 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1531
Query: 297 GRAEDTKLYAPTHKEAEFQAPPEPIQQ-EVERREPEEHQVEEEHRKALEEEEMEQVGQAE 355
R + L A + + ++Q EVER + +E R A E + ++ AE
Sbjct: 1532 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1591
Query: 356 H-------LEEEHDPSPEEQDREWKEQHEQREAANLLEGHARA--EVYPSAKPMIKFQSP 406
L+EEH + ++ + +Q EA E R A ++ +
Sbjct: 1592 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1651
Query: 407 YEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAEL 466
EE +Q+ LA + E+ ++ E +EA + + + +RQ+E +Q+ L++Q +L
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAE-REARRRGKAEEQAVRQRELAEQE------LEKQRQL 1704
Query: 467 EEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGA-YERD----NQHQDEAEGDPG 521
EG Q++L + + + QG + + + EE A +R+ Q + E E +
Sbjct: 1705 AEGTA--QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1762
Query: 522 N-RHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQ 580
R E +A E E+ + + + + + EEA ++R L +E + Q
Sbjct: 1763 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA--LAEEAKRQ 1820
Query: 581 KQ------SNQKQENTEV-EEHLVMAGNPDQQEDNVDEQYQE-EAEEEVQEDLTEE---K 629
+Q + Q+ E V E L G + + + +E EAE E L E+ +
Sbjct: 1821 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1880
Query: 630 KRELEHNAEETYGENDENTDD--KNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVA 687
+R LE A + + +E K +D E + R KG E + + E+
Sbjct: 1881 RRRLEEQAAQHKADIEERLAQLRKASDSELE------RQKGLVEDTLRQRRQVEEEILAL 1934
Query: 688 EKSHRRA 694
+ S +A
Sbjct: 1935 KASFEKA 1941
Score = 59.7 bits (143), Expect = 9e-09
Identities = 132/632 (20%), Positives = 240/632 (37%), Gaps = 106/632 (16%)
Query: 142 QGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQ 201
QG + ++ + K Q EL K ++ LR + + + +L+ ++
Sbjct: 1103 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1162
Query: 202 QHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQV 261
+ L H + V +E + +A L R ++ Q+ + Q+
Sbjct: 1163 VGERLQQRHGERDVEVERWRERVA-------------QLLERWQAVLAQTDVRQRELEQL 1209
Query: 262 AHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPI 321
+ Y + + +Q+ R + Q +A +L + QA E I
Sbjct: 1210 GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-------RQEQALLEEI 1262
Query: 322 QQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREA 381
++ E+ E E + +++ A+++ E++ V LE P+ + + + E Q E
Sbjct: 1263 ERHGEKVE-ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EY 1320
Query: 382 ANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQ-RLAVQQ-VEEAQQLREHQEALH---- 435
+L ++ E+ IKF S ++E++ RLA QQ EE ++L E + AL
Sbjct: 1321 VDLRTHYS--ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1378
Query: 436 -------------------QQRLQGHLLRQQE------QQQQQVAREM------------ 458
QQR+Q ++R++E QQ++ + E+
Sbjct: 1379 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1438
Query: 459 ALQRQAE-LEEGRPQHQEQLR--------QQAHYDAMDNDI------VQGAEDQGIQGEE 503
A RQAE E R + +E++R + + ++ + AE Q Q +E
Sbjct: 1439 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1498
Query: 504 GAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRA--AVEDI----NPADDPNNQ 557
A Q QDE++ E + EA+ E RA A+E++ A+ Q
Sbjct: 1499 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1558
Query: 558 GEDE--------FEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNV 609
E E E A++ E L + + + E + EEH+ +A ++ E
Sbjct: 1559 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1618
Query: 610 DEQYQ-----EEAEEEVQE-DLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDD 663
+Q + EEAE E++ L + L AEE + + EE E
Sbjct: 1619 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1678
Query: 664 NRPKGREEHYEEEEEEEEDGAAVAEKSHRRAE 695
R K E+ + E E++ EK + AE
Sbjct: 1679 RRGKAEEQAVRQRELAEQE----LEKQRQLAE 1706
Score = 54.7 bits (130), Expect = 3e-07
Identities = 79/346 (22%), Positives = 147/346 (42%), Gaps = 54/346 (15%)
Query: 42 KAEAV--ALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQET 99
K +AV A + + E L Q ++ E RL++ KE++ + A+E Q T
Sbjct: 2319 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQED--KEQMAQQLAEET-----QGFQRT 2371
Query: 100 LNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEE---HRKQ----GEDFSRTFND 152
L RQ R ++ + + LK + E+ + + EE+ RKQ GE RT
Sbjct: 2372 LEAERQ----RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2427
Query: 153 HKQKYLQLQ------QEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQ-QHKN 205
++K +Q Q+ + + +L+E + L E +L++ + + + ++++ Q +
Sbjct: 2428 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2487
Query: 206 LLSEHEQLVVTLEDHKSALAAAQTQVAEYKQ-----LKDTLNRIPSLRKPDPAEQQNVTQ 260
LL E + L + K +L + + + K +D + + LR+ +QQ + Q
Sbjct: 2488 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547
Query: 261 VAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPG-RAEDTKLYAPTHKEAEFQAPPE 319
R++ ++E R + HEA G R + +L E + + E
Sbjct: 2548 ----------ERQRLVASMEEARR-----RQHEAEEGVRRKQEELQ---QLEQQRRQQEE 2589
Query: 320 PIQQEVERREPEEHQVEEEHRKAL---EEEEMEQVGQAEHLEEEHD 362
+ +E +R + +EE+HR AL EE QV + L D
Sbjct: 2590 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2635
Score = 50.8 bits (120), Expect = 4e-06
Identities = 64/262 (24%), Positives = 118/262 (45%), Gaps = 41/262 (15%)
Query: 30 AMLYYELQTQLRKAEAVALKYQQ----HQESLSAQLQVVYEH-RSRLEKSLQKER-LEHK 83
A L E + ++A+ + LK ++ QE L + Q + + S + LQ+ER +E +
Sbjct: 2457 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2516
Query: 84 KAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQG 143
KAK + L A+ + R++ + + + Q L + EE +++ + EE R++
Sbjct: 2517 KAKLEQLFQDEVAKA--QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2574
Query: 144 EDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
E+ QL+Q++ Q+ L EEN++LR+ QLQ +++QH
Sbjct: 2575 EELQ-----------QLEQQRRQQEEL-------LAEENQRLRE-------QLQLLEEQH 2609
Query: 204 KNLLSEHEQLVV-------TLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQ 256
+ L+ E++ TL + + AL + AE + D L R S ++ A
Sbjct: 2610 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAE-AEPEHSFDGLRRKVSAQRLQEAGIL 2668
Query: 257 NVTQVAHSPQGYNTAREKPTRE 278
+ ++ QG+ T E RE
Sbjct: 2669 SAEELQRLAQGHTTVDELARRE 2690
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 95.5 bits (236), Expect = 1e-19
Identities = 159/750 (21%), Positives = 313/750 (41%), Gaps = 111/750 (14%)
Query: 39 QLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERL-EHKKAKEDFLVYKL--- 94
Q R+ E A +++ E AQL+ + +K L ++ L + ++ +E+ L K
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935
Query: 95 -----EAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRT 149
+A+ L GR SN+ + + + L++ + +Q + EE R++ E+ +
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ---RQLAAEEERRRREAEERVQK 1992
Query: 150 FNDHKQKYLQLQQEKEQELSKLKETVYNLR--------EENRQLRKAHQDIHTQLQDVKQ 201
+++ + ++ +E+ +LK V R E RQL+ A + +LQ ++
Sbjct: 1993 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2052
Query: 202 QHKNLLSEHEQ-LVVTLEDHKSAL---------AAAQTQVAEYKQLKDTLNRIPSLRKPD 251
H + + EQ L TL+ +S L A + AE +++ S R+ +
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2112
Query: 252 PAEQ--QNVTQVAHSPQGYNTAREKPTREV-QEVSRNNDVWQ----NHEAVPGRAEDTKL 304
AE+ Q+ + A + A EK +E QE +R Q +A E K
Sbjct: 2113 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2172
Query: 305 YAPT--HKEAEFQAPPEPIQQEVERREPEEHQVEEE-------------HRKALEEE--- 346
+A ++A+ + ++ ++E + +++ ++EE R +EEE
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 347 ---EMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLE-GHARAEVYPSAKPMIK 402
+ME++ + + E + + +D++ ++ Q EA + + A + +A+ +
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292
Query: 403 FQSPYEEQLEQQRLA--------VQQVEEAQQLREHQEALHQQR-LQGHLLRQQEQQQQQ 453
+ EE L QQR +Q V+EA +L+ E L QQ+ L R+ ++ ++Q
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 454 VAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQ 513
+A+++A + Q + Q QL A + + + + + Q E+ R Q
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK---Q 2409
Query: 514 DEAEGDPGNRHEPREQGP-----------READPESEADRAAVEDINPADDPNNQGED-- 560
E G+ +R E Q +++D ++E R A+ ++ + Q
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 561 --EFEEAEQVREENLPDENEEQKQS--NQK-----------QENTEVEEHLVMAGNPDQQ 605
+ EE + V++E L E + +QS ++K QE ++E+ QQ
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2529
Query: 606 EDNVDEQYQEEAEEEVQEDLTE-EKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDN 664
++ Q++ E+E Q + E+ R +H AEE E E Q++
Sbjct: 2530 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---------ELQQLEQQR 2580
Query: 665 RPKGREEHYEEEEEEEEDGAAVAEKSHRRA 694
R +EE EE + + + E+ HR A
Sbjct: 2581 RQ--QEELLAEENQRLREQLQLLEEQHRAA 2608
Score = 86.3 bits (212), Expect = 9e-17
Identities = 117/482 (24%), Positives = 214/482 (44%), Gaps = 65/482 (13%)
Query: 35 ELQTQLR-KAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYK 93
E Q Q R +A+A A K ++ E +A+ + R +++ E +HKK E L K
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181
Query: 94 LEAQETLNKGR---QDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEH---RKQGEDFS 147
+ ++ L R ++++ + + L+ + Q LK++ E +Q S +EEE R Q E+ S
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241
Query: 148 RTF--------------NDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIH 193
+ D+ Q++LQ + EK +++++ + +E +LR+ ++
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2299
Query: 194 TQLQDVKQQH---KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKP 250
D+ QQ + +L E Q V + L A + + K+L R+
Sbjct: 2300 ----DLAQQRALAEKMLKEKMQAV----QEATRLKAEAELLQQQKELAQE-----QARRL 2346
Query: 251 DPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHK 310
++Q Q+A QG+ E + E+S + + A RA+ A +
Sbjct: 2347 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ-----ARAEE 2401
Query: 311 EAE-FQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEE---EHDPSPE 366
+A+ F+ E I +++ R E Q + + LE + + AE L E E + E
Sbjct: 2402 DAQRFRKQAEEIGEKLHRTELAT-QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2460
Query: 367 EQDREWK-------EQHEQREAANLLEGHARAEVYPSAKPMIKFQSPY--EEQLEQQRLA 417
+ +E K E ++ L E A + + S K + + + +E+ + ++L
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520
Query: 418 VQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQL 477
+V +AQQLRE Q+ QQ +QE+Q+ + E A +RQ E EEG + QE+L
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQM-------EQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2573
Query: 478 RQ 479
+Q
Sbjct: 2574 QQ 2575
Score = 80.5 bits (197), Expect = 5e-15
Identities = 154/754 (20%), Positives = 291/754 (38%), Gaps = 110/754 (14%)
Query: 35 ELQTQLRKAEAVA---LKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLV 91
E+Q + R+AEA L+ ++ + QL+ R E LQ R ++A+
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 92 YKLEAQETLNKGRQDSNSRYSALNVQ-HQMLKSQHEELKKQHSDLE--EEHRKQGEDFSR 148
+ EA E L + QD + R V+ +K++ E +++ L+ EE R Q E+ R
Sbjct: 1492 AQEEA-ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1550
Query: 149 TFNDH-----KQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
+Q + L+ + ++L+ + E+ QL ++ Q+ H + ++++
Sbjct: 1551 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1610
Query: 204 KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH 263
+ + + E+ + L Q + E +L+ L+ + A+Q+++ Q
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLR--------LQAEEVAQQKSLAQAEA 1662
Query: 264 SPQGYNTARE----------------------KPTREVQEVSRNNDVWQNHEAVPGRAE- 300
Q RE + R++ E + + E + RAE
Sbjct: 1663 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1722
Query: 301 -----------------DTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKAL 343
+ A T K E +A ++ E+E + + EEE R
Sbjct: 1723 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1782
Query: 344 EEEEME---QVGQAEHLEEEHD-----PSPEEQDREWKEQHEQREAANLLEGHARAEVYP 395
E+ + + G+ L EE ++ R+ E+ R+ A A
Sbjct: 1783 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842
Query: 396 SAKPMIKFQSPY---EEQLEQQRLAVQQVEEAQQLR--EHQEALHQQRLQGHLLRQQEQQ 450
+K ++ E++ E +RL +EA Q R E Q A H+ ++ L + ++
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1902
Query: 451 QQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMD----------NDIVQGAEDQGIQ 500
++ R+ L L + R +E L +A ++ I AED
Sbjct: 1903 DSELERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 501 GEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADR---AAVEDINPADDPNNQ 557
E+ E Q Q AE + R E E+ + E EA R AA+E++
Sbjct: 1962 KEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEVERL------ 2014
Query: 558 GEDEFEEAEQVREENLPDENEE---QKQSNQKQENTEVEEHLVMAGNPD-------QQED 607
+ + EEA ++RE + + +++ QK+ E + H + QQE
Sbjct: 2015 -KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2073
Query: 608 NVDEQYQEEAEEEVQ-EDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRP 666
+V +Q + EAE + + EE + + E A ++ + +E K + E+ + R +
Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2133
Query: 667 KGREEHYEEEEE----EEEDGAAVAEKSHRRAEM 696
+ E E+E + + AA+ +K AEM
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2167
Score = 76.3 bits (186), Expect = 9e-14
Identities = 139/679 (20%), Positives = 259/679 (38%), Gaps = 61/679 (8%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRL---------EKSLQKERLEHKKA 85
E + Q + AE A + + E + A+ +RL EK + ERL
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1871
Query: 86 KEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEE--EHRKQG 143
E F +LE Q +K D R + Q+ K+ EL++Q +E+ R+Q
Sbjct: 1872 DEAFQRRRLEEQAAQHKA--DIEERLA------QLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 144 EDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
E+ +K + E E EL +++ N + R +A + Q Q ++
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRS---NAEDTLRSKEQAELEAARQRQLAAEEE 1980
Query: 204 KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH 263
+ E++ +L + A + + E ++LK + LR+ E Q+A
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040
Query: 264 SPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQ 323
E+ + ++ Q + + + A + A +A +Q
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2100
Query: 324 EVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAAN 383
E E + E E K EE+ + QA+ E+ +E ++E + + +AA
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK---LRKEAEQEAARRAQAEQAAL 2157
Query: 384 LLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLR-EHQEALHQQRLQGH 442
+ A AE+ K + EQ +Q+ V+Q E LR + +E HQ+ L
Sbjct: 2158 RQKQAADAEMEKHKK--------FAEQTLRQKAQVEQ--ELTTLRLQLEETDHQKNLLDE 2207
Query: 443 LLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGE 502
L++ + + + AR+ + Q + EL R Q +E + +A +A + ++ +D +
Sbjct: 2208 ELQRLKAEATEAARQRS-QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266
Query: 503 EGAYERDNQHQDE-----------------AEGDPGNRHEPREQGPRE-ADPESEADRAA 544
+ E+ Q +E AE D + E+ +E EA R
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2326
Query: 545 VEDINPADDPNNQGEDEFEEAEQVRE--ENLPDENEEQKQSNQKQENTEVEEHLVMAGNP 602
E A+ Q E E+A +++E E + + E+ Q Q+ E + L M+
Sbjct: 2327 AE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382
Query: 603 DQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRD 662
++ + V E + +A E ++ E+ T E +++ D
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442
Query: 663 DNRPKGREEHYEEEEEEEE 681
+ + RE E E E+E+
Sbjct: 2443 HDAERLREAIAELEREKEK 2461
Score = 71.6 bits (174), Expect = 2e-12
Identities = 97/435 (22%), Positives = 185/435 (42%), Gaps = 38/435 (8%)
Query: 31 MLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKER----LEHKKAK 86
+L ELQ +A A + Q +E L + ++V E S+L+ ++ E L K
Sbjct: 2204 LLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKLKARIEAENRALILRDKDNT 2262
Query: 87 EDFLVYKLEAQETLNKGRQ--DSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGE 144
+ FL QE K +Q + +R S + L+ EE Q L E+ K+
Sbjct: 2263 QRFL------QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316
Query: 145 DFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHK 204
+ K + LQQ+KE + + + + +QL + Q L+ +Q+
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 205 NLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH- 263
+ +E E+L + + + A A A+ +++ + + L + + A Q+ VT V
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE--KLHRTELATQEKVTLVQTL 2434
Query: 264 --SPQGYNTAREKPTREVQEVSRNND-VWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEP 320
Q + E+ + E+ R + + Q + + ++E+ + E QA +
Sbjct: 2435 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2494
Query: 321 IQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQRE 380
E + E +E+E K LE+ ++V +A+ L EE +++ ++ EQ QR
Sbjct: 2495 FLSEKDSLLQRERFIEQEKAK-LEQLFQDEVAKAQQLREE-----QQRQQQQMEQERQRL 2548
Query: 381 AANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQ 440
A++ E R Q EE + +++ +QQ+E+ ++ +E A QRL+
Sbjct: 2549 VASMEEARRR-------------QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595
Query: 441 GHLLRQQEQQQQQVA 455
L +EQ + +A
Sbjct: 2596 EQLQLLEEQHRAALA 2610
Score = 64.3 bits (155), Expect = 4e-10
Identities = 154/727 (21%), Positives = 293/727 (40%), Gaps = 103/727 (14%)
Query: 43 AEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDF----LVYKLEAQE 98
A++ A++ Q QE A L+ + H ++E+ Q+ ++ A +D+ + YK + +
Sbjct: 1239 ADSQAVREQLRQEQ--ALLEEIERHGEKVEEC-QRFAKQYINAIKDYELQLVTYKAQLEP 1295
Query: 99 TLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYL 158
+ ++ S +Q ++ +L+ +S+L + + S T +++
Sbjct: 1296 VASPAKKPKVQSGSESVIQ------EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 159 QLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQ--------------------- 197
+Q++ +E +L E L E+ RQL +AH Q +
Sbjct: 1350 LAEQQRAEERERLAEVEAAL-EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408
Query: 198 -DVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLK-DTLNRIPSL------RK 249
D +QQ +++ E +QL + E A A Q + AE +L+ + R+ L R+
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQA-KARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467
Query: 250 PDPAEQQNVTQVAHSPQGYNTAR------EKPTREVQEVSRNNDVWQ-------NHEAVP 296
AE + A + + R E+ R+VQ+ S+ + EA
Sbjct: 1468 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1527
Query: 297 GRAEDTKLYAPTHKEAEFQAPPEPIQQ-EVERREPEEHQVEEEHRKALEEEEMEQVGQAE 355
R + L A + + ++Q EVER + +E R A E + ++ AE
Sbjct: 1528 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587
Query: 356 H-------LEEEHDPSPEEQDREWKEQHEQREAANLLEGHARA--EVYPSAKPMIKFQSP 406
L+EEH + ++ + +Q EA E R A ++ +
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Query: 407 YEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAEL 466
EE +Q+ LA + E+ ++ E +EA + + + +RQ+E +Q+ L++Q +L
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAE-REARRRGKAEEQAVRQRELAEQE------LEKQRQL 1700
Query: 467 EEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGA-YERD----NQHQDEAEGDPG 521
EG Q++L + + + QG + + + EE A +R+ Q + E E +
Sbjct: 1701 AEGTA--QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758
Query: 522 N-RHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQ 580
R E +A E E+ + + + + + EEA ++R L +E + Q
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA--LAEEAKRQ 1816
Query: 581 KQ------SNQKQENTEV-EEHLVMAGNPDQQEDNVDEQYQE-EAEEEVQEDLTEE---K 629
+Q + Q+ E V E L G + + + +E EAE E L E+ +
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 630 KRELEHNAEETYGENDENTDD--KNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVA 687
+R LE A + + +E K +D E + R KG E + + E+
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELE------RQKGLVEDTLRQRRQVEEEILAL 1930
Query: 688 EKSHRRA 694
+ S +A
Sbjct: 1931 KASFEKA 1937
Score = 59.7 bits (143), Expect = 9e-09
Identities = 132/632 (20%), Positives = 240/632 (37%), Gaps = 106/632 (16%)
Query: 142 QGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQ 201
QG + ++ + K Q EL K ++ LR + + + +L+ ++
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158
Query: 202 QHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQV 261
+ L H + V +E + +A L R ++ Q+ + Q+
Sbjct: 1159 VGERLQQRHGERDVEVERWRERVA-------------QLLERWQAVLAQTDVRQRELEQL 1205
Query: 262 AHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPI 321
+ Y + + +Q+ R + Q +A +L + QA E I
Sbjct: 1206 GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-------RQEQALLEEI 1258
Query: 322 QQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREA 381
++ E+ E E + +++ A+++ E++ V LE P+ + + + E Q E
Sbjct: 1259 ERHGEKVE-ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EY 1316
Query: 382 ANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQ-RLAVQQ-VEEAQQLREHQEALH---- 435
+L ++ E+ IKF S ++E++ RLA QQ EE ++L E + AL
Sbjct: 1317 VDLRTHYS--ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1374
Query: 436 -------------------QQRLQGHLLRQQE------QQQQQVAREM------------ 458
QQR+Q ++R++E QQ++ + E+
Sbjct: 1375 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1434
Query: 459 ALQRQAE-LEEGRPQHQEQLR--------QQAHYDAMDNDI------VQGAEDQGIQGEE 503
A RQAE E R + +E++R + + ++ + AE Q Q +E
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1494
Query: 504 GAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRA--AVEDI----NPADDPNNQ 557
A Q QDE++ E + EA+ E RA A+E++ A+ Q
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1554
Query: 558 GEDE--------FEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNV 609
E E E A++ E L + + + E + EEH+ +A ++ E
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1614
Query: 610 DEQYQ-----EEAEEEVQE-DLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDD 663
+Q + EEAE E++ L + L AEE + + EE E
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1674
Query: 664 NRPKGREEHYEEEEEEEEDGAAVAEKSHRRAE 695
R K E+ + E E++ EK + AE
Sbjct: 1675 RRGKAEEQAVRQRELAEQE----LEKQRQLAE 1702
Score = 54.7 bits (130), Expect = 3e-07
Identities = 79/346 (22%), Positives = 147/346 (42%), Gaps = 54/346 (15%)
Query: 42 KAEAV--ALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQET 99
K +AV A + + E L Q ++ E RL++ KE++ + A+E Q T
Sbjct: 2315 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQED--KEQMAQQLAEET-----QGFQRT 2367
Query: 100 LNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEE---HRKQ----GEDFSRTFND 152
L RQ R ++ + + LK + E+ + + EE+ RKQ GE RT
Sbjct: 2368 LEAERQ----RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423
Query: 153 HKQKYLQLQ------QEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQ-QHKN 205
++K +Q Q+ + + +L+E + L E +L++ + + + ++++ Q +
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2483
Query: 206 LLSEHEQLVVTLEDHKSALAAAQTQVAEYKQ-----LKDTLNRIPSLRKPDPAEQQNVTQ 260
LL E + L + K +L + + + K +D + + LR+ +QQ + Q
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 261 VAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPG-RAEDTKLYAPTHKEAEFQAPPE 319
R++ ++E R + HEA G R + +L E + + E
Sbjct: 2544 ----------ERQRLVASMEEARR-----RQHEAEEGVRRKQEELQ---QLEQQRRQQEE 2585
Query: 320 PIQQEVERREPEEHQVEEEHRKAL---EEEEMEQVGQAEHLEEEHD 362
+ +E +R + +EE+HR AL EE QV + L D
Sbjct: 2586 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2631
Score = 50.8 bits (120), Expect = 4e-06
Identities = 64/262 (24%), Positives = 118/262 (45%), Gaps = 41/262 (15%)
Query: 30 AMLYYELQTQLRKAEAVALKYQQ----HQESLSAQLQVVYEH-RSRLEKSLQKER-LEHK 83
A L E + ++A+ + LK ++ QE L + Q + + S + LQ+ER +E +
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2512
Query: 84 KAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQG 143
KAK + L A+ + R++ + + + Q L + EE +++ + EE R++
Sbjct: 2513 KAKLEQLFQDEVAKA--QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570
Query: 144 EDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
E+ QL+Q++ Q+ L EEN++LR+ QLQ +++QH
Sbjct: 2571 EELQ-----------QLEQQRRQQEEL-------LAEENQRLRE-------QLQLLEEQH 2605
Query: 204 KNLLSEHEQLVV-------TLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQ 256
+ L+ E++ TL + + AL + AE + D L R S ++ A
Sbjct: 2606 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAE-AEPEHSFDGLRRKVSAQRLQEAGIL 2664
Query: 257 NVTQVAHSPQGYNTAREKPTRE 278
+ ++ QG+ T E RE
Sbjct: 2665 SAEELQRLAQGHTTVDELARRE 2686
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 95.5 bits (236), Expect = 1e-19
Identities = 159/750 (21%), Positives = 313/750 (41%), Gaps = 111/750 (14%)
Query: 39 QLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERL-EHKKAKEDFLVYKL--- 94
Q R+ E A +++ E AQL+ + +K L ++ L + ++ +E+ L K
Sbjct: 1844 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1903
Query: 95 -----EAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRT 149
+A+ L GR SN+ + + + L++ + +Q + EE R++ E+ +
Sbjct: 1904 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ---RQLAAEEERRRREAEERVQK 1960
Query: 150 FNDHKQKYLQLQQEKEQELSKLKETVYNLR--------EENRQLRKAHQDIHTQLQDVKQ 201
+++ + ++ +E+ +LK V R E RQL+ A + +LQ ++
Sbjct: 1961 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2020
Query: 202 QHKNLLSEHEQ-LVVTLEDHKSAL---------AAAQTQVAEYKQLKDTLNRIPSLRKPD 251
H + + EQ L TL+ +S L A + AE +++ S R+ +
Sbjct: 2021 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2080
Query: 252 PAEQ--QNVTQVAHSPQGYNTAREKPTREV-QEVSRNNDVWQ----NHEAVPGRAEDTKL 304
AE+ Q+ + A + A EK +E QE +R Q +A E K
Sbjct: 2081 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2140
Query: 305 YAPT--HKEAEFQAPPEPIQQEVERREPEEHQVEEE-------------HRKALEEE--- 346
+A ++A+ + ++ ++E + +++ ++EE R +EEE
Sbjct: 2141 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2200
Query: 347 ---EMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLE-GHARAEVYPSAKPMIK 402
+ME++ + + E + + +D++ ++ Q EA + + A + +A+ +
Sbjct: 2201 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2260
Query: 403 FQSPYEEQLEQQRLA--------VQQVEEAQQLREHQEALHQQR-LQGHLLRQQEQQQQQ 453
+ EE L QQR +Q V+EA +L+ E L QQ+ L R+ ++ ++Q
Sbjct: 2261 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2320
Query: 454 VAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQ 513
+A+++A + Q + Q QL A + + + + + Q E+ R Q
Sbjct: 2321 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK---Q 2377
Query: 514 DEAEGDPGNRHEPREQGP-----------READPESEADRAAVEDINPADDPNNQGED-- 560
E G+ +R E Q +++D ++E R A+ ++ + Q
Sbjct: 2378 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2437
Query: 561 --EFEEAEQVREENLPDENEEQKQS--NQK-----------QENTEVEEHLVMAGNPDQQ 605
+ EE + V++E L E + +QS ++K QE ++E+ QQ
Sbjct: 2438 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2497
Query: 606 EDNVDEQYQEEAEEEVQEDLTE-EKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDN 664
++ Q++ E+E Q + E+ R +H AEE E E Q++
Sbjct: 2498 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---------ELQQLEQQR 2548
Query: 665 RPKGREEHYEEEEEEEEDGAAVAEKSHRRA 694
R +EE EE + + + E+ HR A
Sbjct: 2549 RQ--QEELLAEENQRLREQLQLLEEQHRAA 2576
Score = 86.3 bits (212), Expect = 9e-17
Identities = 117/482 (24%), Positives = 214/482 (44%), Gaps = 65/482 (13%)
Query: 35 ELQTQLR-KAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYK 93
E Q Q R +A+A A K ++ E +A+ + R +++ E +HKK E L K
Sbjct: 2090 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2149
Query: 94 LEAQETLNKGR---QDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEH---RKQGEDFS 147
+ ++ L R ++++ + + L+ + Q LK++ E +Q S +EEE R Q E+ S
Sbjct: 2150 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2209
Query: 148 RTF--------------NDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIH 193
+ D+ Q++LQ + EK +++++ + +E +LR+ ++
Sbjct: 2210 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2267
Query: 194 TQLQDVKQQH---KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKP 250
D+ QQ + +L E Q V + L A + + K+L R+
Sbjct: 2268 ----DLAQQRALAEKMLKEKMQAV----QEATRLKAEAELLQQQKELAQE-----QARRL 2314
Query: 251 DPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHK 310
++Q Q+A QG+ E + E+S + + A RA+ A +
Sbjct: 2315 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ-----ARAEE 2369
Query: 311 EAE-FQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEE---EHDPSPE 366
+A+ F+ E I +++ R E Q + + LE + + AE L E E + E
Sbjct: 2370 DAQRFRKQAEEIGEKLHRTELAT-QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2428
Query: 367 EQDREWK-------EQHEQREAANLLEGHARAEVYPSAKPMIKFQSPY--EEQLEQQRLA 417
+ +E K E ++ L E A + + S K + + + +E+ + ++L
Sbjct: 2429 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2488
Query: 418 VQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQL 477
+V +AQQLRE Q+ QQ +QE+Q+ + E A +RQ E EEG + QE+L
Sbjct: 2489 QDEVAKAQQLREEQQRQQQQM-------EQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2541
Query: 478 RQ 479
+Q
Sbjct: 2542 QQ 2543
Score = 80.5 bits (197), Expect = 5e-15
Identities = 154/754 (20%), Positives = 291/754 (38%), Gaps = 110/754 (14%)
Query: 35 ELQTQLRKAEAVA---LKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLV 91
E+Q + R+AEA L+ ++ + QL+ R E LQ R ++A+
Sbjct: 1400 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1459
Query: 92 YKLEAQETLNKGRQDSNSRYSALNVQ-HQMLKSQHEELKKQHSDLE--EEHRKQGEDFSR 148
+ EA E L + QD + R V+ +K++ E +++ L+ EE R Q E+ R
Sbjct: 1460 AQEEA-ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1518
Query: 149 TFNDH-----KQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
+Q + L+ + ++L+ + E+ QL ++ Q+ H + ++++
Sbjct: 1519 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1578
Query: 204 KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH 263
+ + + E+ + L Q + E +L+ L+ + A+Q+++ Q
Sbjct: 1579 ERRAQQQAEAERAREEAERELERWQLKANEALRLR--------LQAEEVAQQKSLAQAEA 1630
Query: 264 SPQGYNTARE----------------------KPTREVQEVSRNNDVWQNHEAVPGRAE- 300
Q RE + R++ E + + E + RAE
Sbjct: 1631 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1690
Query: 301 -----------------DTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKAL 343
+ A T K E +A ++ E+E + + EEE R
Sbjct: 1691 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1750
Query: 344 EEEEME---QVGQAEHLEEEHD-----PSPEEQDREWKEQHEQREAANLLEGHARAEVYP 395
E+ + + G+ L EE ++ R+ E+ R+ A A
Sbjct: 1751 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1810
Query: 396 SAKPMIKFQSPY---EEQLEQQRLAVQQVEEAQQLR--EHQEALHQQRLQGHLLRQQEQQ 450
+K ++ E++ E +RL +EA Q R E Q A H+ ++ L + ++
Sbjct: 1811 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1870
Query: 451 QQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMD----------NDIVQGAEDQGIQ 500
++ R+ L L + R +E L +A ++ I AED
Sbjct: 1871 DSELERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1929
Query: 501 GEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADR---AAVEDINPADDPNNQ 557
E+ E Q Q AE + R E E+ + E EA R AA+E++
Sbjct: 1930 KEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEVERL------ 1982
Query: 558 GEDEFEEAEQVREENLPDENEE---QKQSNQKQENTEVEEHLVMAGNPD-------QQED 607
+ + EEA ++RE + + +++ QK+ E + H + QQE
Sbjct: 1983 -KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2041
Query: 608 NVDEQYQEEAEEEVQ-EDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRP 666
+V +Q + EAE + + EE + + E A ++ + +E K + E+ + R +
Sbjct: 2042 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2101
Query: 667 KGREEHYEEEEE----EEEDGAAVAEKSHRRAEM 696
+ E E+E + + AA+ +K AEM
Sbjct: 2102 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2135
Score = 76.3 bits (186), Expect = 9e-14
Identities = 139/679 (20%), Positives = 259/679 (38%), Gaps = 61/679 (8%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRL---------EKSLQKERLEHKKA 85
E + Q + AE A + + E + A+ +RL EK + ERL
Sbjct: 1780 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1839
Query: 86 KEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEE--EHRKQG 143
E F +LE Q +K D R + Q+ K+ EL++Q +E+ R+Q
Sbjct: 1840 DEAFQRRRLEEQAAQHKA--DIEERLA------QLRKASDSELERQKGLVEDTLRQRRQV 1891
Query: 144 EDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
E+ +K + E E EL +++ N + R +A + Q Q ++
Sbjct: 1892 EEEILALKASFEKAAAGKAELELELGRIRS---NAEDTLRSKEQAELEAARQRQLAAEEE 1948
Query: 204 KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH 263
+ E++ +L + A + + E ++LK + LR+ E Q+A
Sbjct: 1949 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2008
Query: 264 SPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQ 323
E+ + ++ Q + + + A + A +A +Q
Sbjct: 2009 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2068
Query: 324 EVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAAN 383
E E + E E K EE+ + QA+ E+ +E ++E + + +AA
Sbjct: 2069 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK---LRKEAEQEAARRAQAEQAAL 2125
Query: 384 LLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLR-EHQEALHQQRLQGH 442
+ A AE+ K + EQ +Q+ V+Q E LR + +E HQ+ L
Sbjct: 2126 RQKQAADAEMEKHKK--------FAEQTLRQKAQVEQ--ELTTLRLQLEETDHQKNLLDE 2175
Query: 443 LLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGE 502
L++ + + + AR+ + Q + EL R Q +E + +A +A + ++ +D +
Sbjct: 2176 ELQRLKAEATEAARQRS-QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2234
Query: 503 EGAYERDNQHQDE-----------------AEGDPGNRHEPREQGPRE-ADPESEADRAA 544
+ E+ Q +E AE D + E+ +E EA R
Sbjct: 2235 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2294
Query: 545 VEDINPADDPNNQGEDEFEEAEQVRE--ENLPDENEEQKQSNQKQENTEVEEHLVMAGNP 602
E A+ Q E E+A +++E E + + E+ Q Q+ E + L M+
Sbjct: 2295 AE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2350
Query: 603 DQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRD 662
++ + V E + +A E ++ E+ T E +++ D
Sbjct: 2351 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2410
Query: 663 DNRPKGREEHYEEEEEEEE 681
+ + RE E E E+E+
Sbjct: 2411 HDAERLREAIAELEREKEK 2429
Score = 71.6 bits (174), Expect = 2e-12
Identities = 97/435 (22%), Positives = 185/435 (42%), Gaps = 38/435 (8%)
Query: 31 MLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKER----LEHKKAK 86
+L ELQ +A A + Q +E L + ++V E S+L+ ++ E L K
Sbjct: 2172 LLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKLKARIEAENRALILRDKDNT 2230
Query: 87 EDFLVYKLEAQETLNKGRQ--DSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGE 144
+ FL QE K +Q + +R S + L+ EE Q L E+ K+
Sbjct: 2231 QRFL------QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2284
Query: 145 DFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHK 204
+ K + LQQ+KE + + + + +QL + Q L+ +Q+
Sbjct: 2285 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2344
Query: 205 NLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH- 263
+ +E E+L + + + A A A+ +++ + + L + + A Q+ VT V
Sbjct: 2345 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE--KLHRTELATQEKVTLVQTL 2402
Query: 264 --SPQGYNTAREKPTREVQEVSRNND-VWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEP 320
Q + E+ + E+ R + + Q + + ++E+ + E QA +
Sbjct: 2403 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2462
Query: 321 IQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQRE 380
E + E +E+E K LE+ ++V +A+ L EE +++ ++ EQ QR
Sbjct: 2463 FLSEKDSLLQRERFIEQEKAK-LEQLFQDEVAKAQQLREE-----QQRQQQQMEQERQRL 2516
Query: 381 AANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQ 440
A++ E R Q EE + +++ +QQ+E+ ++ +E A QRL+
Sbjct: 2517 VASMEEARRR-------------QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2563
Query: 441 GHLLRQQEQQQQQVA 455
L +EQ + +A
Sbjct: 2564 EQLQLLEEQHRAALA 2578
Score = 64.3 bits (155), Expect = 4e-10
Identities = 154/727 (21%), Positives = 293/727 (40%), Gaps = 103/727 (14%)
Query: 43 AEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDF----LVYKLEAQE 98
A++ A++ Q QE A L+ + H ++E+ Q+ ++ A +D+ + YK + +
Sbjct: 1207 ADSQAVREQLRQEQ--ALLEEIERHGEKVEEC-QRFAKQYINAIKDYELQLVTYKAQLEP 1263
Query: 99 TLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYL 158
+ ++ S +Q ++ +L+ +S+L + + S T +++
Sbjct: 1264 VASPAKKPKVQSGSESVIQ------EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1317
Query: 159 QLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQ--------------------- 197
+Q++ +E +L E L E+ RQL +AH Q +
Sbjct: 1318 LAEQQRAEERERLAEVEAAL-EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1376
Query: 198 -DVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLK-DTLNRIPSL------RK 249
D +QQ +++ E +QL + E A A Q + AE +L+ + R+ L R+
Sbjct: 1377 VDAQQQKRSIQEELQQLRQSSEAEIQA-KARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1435
Query: 250 PDPAEQQNVTQVAHSPQGYNTAR------EKPTREVQEVSRNNDVWQ-------NHEAVP 296
AE + A + + R E+ R+VQ+ S+ + EA
Sbjct: 1436 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1495
Query: 297 GRAEDTKLYAPTHKEAEFQAPPEPIQQ-EVERREPEEHQVEEEHRKALEEEEMEQVGQAE 355
R + L A + + ++Q EVER + +E R A E + ++ AE
Sbjct: 1496 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1555
Query: 356 H-------LEEEHDPSPEEQDREWKEQHEQREAANLLEGHARA--EVYPSAKPMIKFQSP 406
L+EEH + ++ + +Q EA E R A ++ +
Sbjct: 1556 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1615
Query: 407 YEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAEL 466
EE +Q+ LA + E+ ++ E +EA + + + +RQ+E +Q+ L++Q +L
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAE-REARRRGKAEEQAVRQRELAEQE------LEKQRQL 1668
Query: 467 EEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGA-YERD----NQHQDEAEGDPG 521
EG Q++L + + + QG + + + EE A +R+ Q + E E +
Sbjct: 1669 AEGTA--QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1726
Query: 522 N-RHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQ 580
R E +A E E+ + + + + + EEA ++R L +E + Q
Sbjct: 1727 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA--LAEEAKRQ 1784
Query: 581 KQ------SNQKQENTEV-EEHLVMAGNPDQQEDNVDEQYQE-EAEEEVQEDLTEE---K 629
+Q + Q+ E V E L G + + + +E EAE E L E+ +
Sbjct: 1785 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1844
Query: 630 KRELEHNAEETYGENDENTDD--KNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVA 687
+R LE A + + +E K +D E + R KG E + + E+
Sbjct: 1845 RRRLEEQAAQHKADIEERLAQLRKASDSELE------RQKGLVEDTLRQRRQVEEEILAL 1898
Query: 688 EKSHRRA 694
+ S +A
Sbjct: 1899 KASFEKA 1905
Score = 59.7 bits (143), Expect = 9e-09
Identities = 132/632 (20%), Positives = 240/632 (37%), Gaps = 106/632 (16%)
Query: 142 QGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQ 201
QG + ++ + K Q EL K ++ LR + + + +L+ ++
Sbjct: 1067 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1126
Query: 202 QHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQV 261
+ L H + V +E + +A L R ++ Q+ + Q+
Sbjct: 1127 VGERLQQRHGERDVEVERWRERVA-------------QLLERWQAVLAQTDVRQRELEQL 1173
Query: 262 AHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPI 321
+ Y + + +Q+ R + Q +A +L + QA E I
Sbjct: 1174 GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-------RQEQALLEEI 1226
Query: 322 QQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREA 381
++ E+ E E + +++ A+++ E++ V LE P+ + + + E Q E
Sbjct: 1227 ERHGEKVE-ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EY 1284
Query: 382 ANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQ-RLAVQQ-VEEAQQLREHQEALH---- 435
+L ++ E+ IKF S ++E++ RLA QQ EE ++L E + AL
Sbjct: 1285 VDLRTHYS--ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1342
Query: 436 -------------------QQRLQGHLLRQQE------QQQQQVAREM------------ 458
QQR+Q ++R++E QQ++ + E+
Sbjct: 1343 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1402
Query: 459 ALQRQAE-LEEGRPQHQEQLR--------QQAHYDAMDNDI------VQGAEDQGIQGEE 503
A RQAE E R + +E++R + + ++ + AE Q Q +E
Sbjct: 1403 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1462
Query: 504 GAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRA--AVEDI----NPADDPNNQ 557
A Q QDE++ E + EA+ E RA A+E++ A+ Q
Sbjct: 1463 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1522
Query: 558 GEDE--------FEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNV 609
E E E A++ E L + + + E + EEH+ +A ++ E
Sbjct: 1523 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1582
Query: 610 DEQYQ-----EEAEEEVQE-DLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDD 663
+Q + EEAE E++ L + L AEE + + EE E
Sbjct: 1583 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1642
Query: 664 NRPKGREEHYEEEEEEEEDGAAVAEKSHRRAE 695
R K E+ + E E++ EK + AE
Sbjct: 1643 RRGKAEEQAVRQRELAEQE----LEKQRQLAE 1670
Score = 54.7 bits (130), Expect = 3e-07
Identities = 79/346 (22%), Positives = 147/346 (42%), Gaps = 54/346 (15%)
Query: 42 KAEAV--ALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQET 99
K +AV A + + E L Q ++ E RL++ KE++ + A+E Q T
Sbjct: 2283 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQED--KEQMAQQLAEET-----QGFQRT 2335
Query: 100 LNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEE---HRKQ----GEDFSRTFND 152
L RQ R ++ + + LK + E+ + + EE+ RKQ GE RT
Sbjct: 2336 LEAERQ----RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2391
Query: 153 HKQKYLQLQ------QEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQ-QHKN 205
++K +Q Q+ + + +L+E + L E +L++ + + + ++++ Q +
Sbjct: 2392 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2451
Query: 206 LLSEHEQLVVTLEDHKSALAAAQTQVAEYKQ-----LKDTLNRIPSLRKPDPAEQQNVTQ 260
LL E + L + K +L + + + K +D + + LR+ +QQ + Q
Sbjct: 2452 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511
Query: 261 VAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPG-RAEDTKLYAPTHKEAEFQAPPE 319
R++ ++E R + HEA G R + +L E + + E
Sbjct: 2512 ----------ERQRLVASMEEARR-----RQHEAEEGVRRKQEELQ---QLEQQRRQQEE 2553
Query: 320 PIQQEVERREPEEHQVEEEHRKAL---EEEEMEQVGQAEHLEEEHD 362
+ +E +R + +EE+HR AL EE QV + L D
Sbjct: 2554 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2599
Score = 50.8 bits (120), Expect = 4e-06
Identities = 64/262 (24%), Positives = 118/262 (45%), Gaps = 41/262 (15%)
Query: 30 AMLYYELQTQLRKAEAVALKYQQ----HQESLSAQLQVVYEH-RSRLEKSLQKER-LEHK 83
A L E + ++A+ + LK ++ QE L + Q + + S + LQ+ER +E +
Sbjct: 2421 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2480
Query: 84 KAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQG 143
KAK + L A+ + R++ + + + Q L + EE +++ + EE R++
Sbjct: 2481 KAKLEQLFQDEVAKA--QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2538
Query: 144 EDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
E+ QL+Q++ Q+ L EEN++LR+ QLQ +++QH
Sbjct: 2539 EELQ-----------QLEQQRRQQEEL-------LAEENQRLRE-------QLQLLEEQH 2573
Query: 204 KNLLSEHEQLVV-------TLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQ 256
+ L+ E++ TL + + AL + AE + D L R S ++ A
Sbjct: 2574 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAE-AEPEHSFDGLRRKVSAQRLQEAGIL 2632
Query: 257 NVTQVAHSPQGYNTAREKPTRE 278
+ ++ QG+ T E RE
Sbjct: 2633 SAEELQRLAQGHTTVDELARRE 2654
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 95.5 bits (236), Expect = 1e-19
Identities = 159/750 (21%), Positives = 313/750 (41%), Gaps = 111/750 (14%)
Query: 39 QLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERL-EHKKAKEDFLVYKL--- 94
Q R+ E A +++ E AQL+ + +K L ++ L + ++ +E+ L K
Sbjct: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 2072
Query: 95 -----EAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRT 149
+A+ L GR SN+ + + + L++ + +Q + EE R++ E+ +
Sbjct: 2073 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ---RQLAAEEERRRREAEERVQK 2129
Query: 150 FNDHKQKYLQLQQEKEQELSKLKETVYNLR--------EENRQLRKAHQDIHTQLQDVKQ 201
+++ + ++ +E+ +LK V R E RQL+ A + +LQ ++
Sbjct: 2130 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2189
Query: 202 QHKNLLSEHEQ-LVVTLEDHKSAL---------AAAQTQVAEYKQLKDTLNRIPSLRKPD 251
H + + EQ L TL+ +S L A + AE +++ S R+ +
Sbjct: 2190 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2249
Query: 252 PAEQ--QNVTQVAHSPQGYNTAREKPTREV-QEVSRNNDVWQ----NHEAVPGRAEDTKL 304
AE+ Q+ + A + A EK +E QE +R Q +A E K
Sbjct: 2250 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2309
Query: 305 YAPT--HKEAEFQAPPEPIQQEVERREPEEHQVEEE-------------HRKALEEE--- 346
+A ++A+ + ++ ++E + +++ ++EE R +EEE
Sbjct: 2310 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2369
Query: 347 ---EMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLE-GHARAEVYPSAKPMIK 402
+ME++ + + E + + +D++ ++ Q EA + + A + +A+ +
Sbjct: 2370 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2429
Query: 403 FQSPYEEQLEQQRLA--------VQQVEEAQQLREHQEALHQQR-LQGHLLRQQEQQQQQ 453
+ EE L QQR +Q V+EA +L+ E L QQ+ L R+ ++ ++Q
Sbjct: 2430 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2489
Query: 454 VAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQ 513
+A+++A + Q + Q QL A + + + + + Q E+ R Q
Sbjct: 2490 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK---Q 2546
Query: 514 DEAEGDPGNRHEPREQGP-----------READPESEADRAAVEDINPADDPNNQGED-- 560
E G+ +R E Q +++D ++E R A+ ++ + Q
Sbjct: 2547 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2606
Query: 561 --EFEEAEQVREENLPDENEEQKQS--NQK-----------QENTEVEEHLVMAGNPDQQ 605
+ EE + V++E L E + +QS ++K QE ++E+ QQ
Sbjct: 2607 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2666
Query: 606 EDNVDEQYQEEAEEEVQEDLTE-EKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDN 664
++ Q++ E+E Q + E+ R +H AEE E E Q++
Sbjct: 2667 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---------ELQQLEQQR 2717
Query: 665 RPKGREEHYEEEEEEEEDGAAVAEKSHRRA 694
R +EE EE + + + E+ HR A
Sbjct: 2718 RQ--QEELLAEENQRLREQLQLLEEQHRAA 2745
Score = 86.3 bits (212), Expect = 9e-17
Identities = 117/482 (24%), Positives = 214/482 (44%), Gaps = 65/482 (13%)
Query: 35 ELQTQLR-KAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYK 93
E Q Q R +A+A A K ++ E +A+ + R +++ E +HKK E L K
Sbjct: 2259 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2318
Query: 94 LEAQETLNKGR---QDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEH---RKQGEDFS 147
+ ++ L R ++++ + + L+ + Q LK++ E +Q S +EEE R Q E+ S
Sbjct: 2319 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2378
Query: 148 RTF--------------NDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIH 193
+ D+ Q++LQ + EK +++++ + +E +LR+ ++
Sbjct: 2379 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2436
Query: 194 TQLQDVKQQH---KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKP 250
D+ QQ + +L E Q V + L A + + K+L R+
Sbjct: 2437 ----DLAQQRALAEKMLKEKMQAV----QEATRLKAEAELLQQQKELAQE-----QARRL 2483
Query: 251 DPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHK 310
++Q Q+A QG+ E + E+S + + A RA+ A +
Sbjct: 2484 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ-----ARAEE 2538
Query: 311 EAE-FQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEE---EHDPSPE 366
+A+ F+ E I +++ R E Q + + LE + + AE L E E + E
Sbjct: 2539 DAQRFRKQAEEIGEKLHRTELAT-QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2597
Query: 367 EQDREWK-------EQHEQREAANLLEGHARAEVYPSAKPMIKFQSPY--EEQLEQQRLA 417
+ +E K E ++ L E A + + S K + + + +E+ + ++L
Sbjct: 2598 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2657
Query: 418 VQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQL 477
+V +AQQLRE Q+ QQ +QE+Q+ + E A +RQ E EEG + QE+L
Sbjct: 2658 QDEVAKAQQLREEQQRQQQQM-------EQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2710
Query: 478 RQ 479
+Q
Sbjct: 2711 QQ 2712
Score = 80.5 bits (197), Expect = 5e-15
Identities = 154/754 (20%), Positives = 291/754 (38%), Gaps = 110/754 (14%)
Query: 35 ELQTQLRKAEAVA---LKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLV 91
E+Q + R+AEA L+ ++ + QL+ R E LQ R ++A+
Sbjct: 1569 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1628
Query: 92 YKLEAQETLNKGRQDSNSRYSALNVQ-HQMLKSQHEELKKQHSDLE--EEHRKQGEDFSR 148
+ EA E L + QD + R V+ +K++ E +++ L+ EE R Q E+ R
Sbjct: 1629 AQEEA-ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1687
Query: 149 TFNDH-----KQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
+Q + L+ + ++L+ + E+ QL ++ Q+ H + ++++
Sbjct: 1688 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1747
Query: 204 KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH 263
+ + + E+ + L Q + E +L+ L+ + A+Q+++ Q
Sbjct: 1748 ERRAQQQAEAERAREEAERELERWQLKANEALRLR--------LQAEEVAQQKSLAQAEA 1799
Query: 264 SPQGYNTARE----------------------KPTREVQEVSRNNDVWQNHEAVPGRAE- 300
Q RE + R++ E + + E + RAE
Sbjct: 1800 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1859
Query: 301 -----------------DTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKAL 343
+ A T K E +A ++ E+E + + EEE R
Sbjct: 1860 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1919
Query: 344 EEEEME---QVGQAEHLEEEHD-----PSPEEQDREWKEQHEQREAANLLEGHARAEVYP 395
E+ + + G+ L EE ++ R+ E+ R+ A A
Sbjct: 1920 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1979
Query: 396 SAKPMIKFQSPY---EEQLEQQRLAVQQVEEAQQLR--EHQEALHQQRLQGHLLRQQEQQ 450
+K ++ E++ E +RL +EA Q R E Q A H+ ++ L + ++
Sbjct: 1980 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 2039
Query: 451 QQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMD----------NDIVQGAEDQGIQ 500
++ R+ L L + R +E L +A ++ I AED
Sbjct: 2040 DSELERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 2098
Query: 501 GEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADR---AAVEDINPADDPNNQ 557
E+ E Q Q AE + R E E+ + E EA R AA+E++
Sbjct: 2099 KEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEVERL------ 2151
Query: 558 GEDEFEEAEQVREENLPDENEE---QKQSNQKQENTEVEEHLVMAGNPD-------QQED 607
+ + EEA ++RE + + +++ QK+ E + H + QQE
Sbjct: 2152 -KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2210
Query: 608 NVDEQYQEEAEEEVQ-EDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRP 666
+V +Q + EAE + + EE + + E A ++ + +E K + E+ + R +
Sbjct: 2211 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2270
Query: 667 KGREEHYEEEEE----EEEDGAAVAEKSHRRAEM 696
+ E E+E + + AA+ +K AEM
Sbjct: 2271 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2304
Score = 76.3 bits (186), Expect = 9e-14
Identities = 139/679 (20%), Positives = 259/679 (38%), Gaps = 61/679 (8%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRL---------EKSLQKERLEHKKA 85
E + Q + AE A + + E + A+ +RL EK + ERL
Sbjct: 1949 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 2008
Query: 86 KEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEE--EHRKQG 143
E F +LE Q +K D R + Q+ K+ EL++Q +E+ R+Q
Sbjct: 2009 DEAFQRRRLEEQAAQHKA--DIEERLA------QLRKASDSELERQKGLVEDTLRQRRQV 2060
Query: 144 EDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
E+ +K + E E EL +++ N + R +A + Q Q ++
Sbjct: 2061 EEEILALKASFEKAAAGKAELELELGRIRS---NAEDTLRSKEQAELEAARQRQLAAEEE 2117
Query: 204 KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH 263
+ E++ +L + A + + E ++LK + LR+ E Q+A
Sbjct: 2118 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2177
Query: 264 SPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQ 323
E+ + ++ Q + + + A + A +A +Q
Sbjct: 2178 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2237
Query: 324 EVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAAN 383
E E + E E K EE+ + QA+ E+ +E ++E + + +AA
Sbjct: 2238 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK---LRKEAEQEAARRAQAEQAAL 2294
Query: 384 LLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLR-EHQEALHQQRLQGH 442
+ A AE+ K + EQ +Q+ V+Q E LR + +E HQ+ L
Sbjct: 2295 RQKQAADAEMEKHKK--------FAEQTLRQKAQVEQ--ELTTLRLQLEETDHQKNLLDE 2344
Query: 443 LLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGE 502
L++ + + + AR+ + Q + EL R Q +E + +A +A + ++ +D +
Sbjct: 2345 ELQRLKAEATEAARQRS-QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2403
Query: 503 EGAYERDNQHQDE-----------------AEGDPGNRHEPREQGPRE-ADPESEADRAA 544
+ E+ Q +E AE D + E+ +E EA R
Sbjct: 2404 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2463
Query: 545 VEDINPADDPNNQGEDEFEEAEQVRE--ENLPDENEEQKQSNQKQENTEVEEHLVMAGNP 602
E A+ Q E E+A +++E E + + E+ Q Q+ E + L M+
Sbjct: 2464 AE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2519
Query: 603 DQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRD 662
++ + V E + +A E ++ E+ T E +++ D
Sbjct: 2520 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2579
Query: 663 DNRPKGREEHYEEEEEEEE 681
+ + RE E E E+E+
Sbjct: 2580 HDAERLREAIAELEREKEK 2598
Score = 71.6 bits (174), Expect = 2e-12
Identities = 97/435 (22%), Positives = 185/435 (42%), Gaps = 38/435 (8%)
Query: 31 MLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKER----LEHKKAK 86
+L ELQ +A A + Q +E L + ++V E S+L+ ++ E L K
Sbjct: 2341 LLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKLKARIEAENRALILRDKDNT 2399
Query: 87 EDFLVYKLEAQETLNKGRQ--DSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGE 144
+ FL QE K +Q + +R S + L+ EE Q L E+ K+
Sbjct: 2400 QRFL------QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2453
Query: 145 DFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHK 204
+ K + LQQ+KE + + + + +QL + Q L+ +Q+
Sbjct: 2454 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2513
Query: 205 NLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH- 263
+ +E E+L + + + A A A+ +++ + + L + + A Q+ VT V
Sbjct: 2514 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE--KLHRTELATQEKVTLVQTL 2571
Query: 264 --SPQGYNTAREKPTREVQEVSRNND-VWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEP 320
Q + E+ + E+ R + + Q + + ++E+ + E QA +
Sbjct: 2572 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2631
Query: 321 IQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQRE 380
E + E +E+E K LE+ ++V +A+ L EE +++ ++ EQ QR
Sbjct: 2632 FLSEKDSLLQRERFIEQEKAK-LEQLFQDEVAKAQQLREE-----QQRQQQQMEQERQRL 2685
Query: 381 AANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQ 440
A++ E R Q EE + +++ +QQ+E+ ++ +E A QRL+
Sbjct: 2686 VASMEEARRR-------------QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2732
Query: 441 GHLLRQQEQQQQQVA 455
L +EQ + +A
Sbjct: 2733 EQLQLLEEQHRAALA 2747
Score = 64.3 bits (155), Expect = 4e-10
Identities = 154/727 (21%), Positives = 293/727 (40%), Gaps = 103/727 (14%)
Query: 43 AEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDF----LVYKLEAQE 98
A++ A++ Q QE A L+ + H ++E+ Q+ ++ A +D+ + YK + +
Sbjct: 1376 ADSQAVREQLRQEQ--ALLEEIERHGEKVEEC-QRFAKQYINAIKDYELQLVTYKAQLEP 1432
Query: 99 TLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYL 158
+ ++ S +Q ++ +L+ +S+L + + S T +++
Sbjct: 1433 VASPAKKPKVQSGSESVIQ------EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1486
Query: 159 QLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQ--------------------- 197
+Q++ +E +L E L E+ RQL +AH Q +
Sbjct: 1487 LAEQQRAEERERLAEVEAAL-EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1545
Query: 198 -DVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLK-DTLNRIPSL------RK 249
D +QQ +++ E +QL + E A A Q + AE +L+ + R+ L R+
Sbjct: 1546 VDAQQQKRSIQEELQQLRQSSEAEIQA-KARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1604
Query: 250 PDPAEQQNVTQVAHSPQGYNTAR------EKPTREVQEVSRNNDVWQ-------NHEAVP 296
AE + A + + R E+ R+VQ+ S+ + EA
Sbjct: 1605 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1664
Query: 297 GRAEDTKLYAPTHKEAEFQAPPEPIQQ-EVERREPEEHQVEEEHRKALEEEEMEQVGQAE 355
R + L A + + ++Q EVER + +E R A E + ++ AE
Sbjct: 1665 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1724
Query: 356 H-------LEEEHDPSPEEQDREWKEQHEQREAANLLEGHARA--EVYPSAKPMIKFQSP 406
L+EEH + ++ + +Q EA E R A ++ +
Sbjct: 1725 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1784
Query: 407 YEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAEL 466
EE +Q+ LA + E+ ++ E +EA + + + +RQ+E +Q+ L++Q +L
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAE-REARRRGKAEEQAVRQRELAEQE------LEKQRQL 1837
Query: 467 EEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGA-YERD----NQHQDEAEGDPG 521
EG Q++L + + + QG + + + EE A +R+ Q + E E +
Sbjct: 1838 AEGTA--QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1895
Query: 522 N-RHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQ 580
R E +A E E+ + + + + + EEA ++R L +E + Q
Sbjct: 1896 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA--LAEEAKRQ 1953
Query: 581 KQ------SNQKQENTEV-EEHLVMAGNPDQQEDNVDEQYQE-EAEEEVQEDLTEE---K 629
+Q + Q+ E V E L G + + + +E EAE E L E+ +
Sbjct: 1954 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 2013
Query: 630 KRELEHNAEETYGENDENTDD--KNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVA 687
+R LE A + + +E K +D E + R KG E + + E+
Sbjct: 2014 RRRLEEQAAQHKADIEERLAQLRKASDSELE------RQKGLVEDTLRQRRQVEEEILAL 2067
Query: 688 EKSHRRA 694
+ S +A
Sbjct: 2068 KASFEKA 2074
Score = 59.7 bits (143), Expect = 9e-09
Identities = 132/632 (20%), Positives = 240/632 (37%), Gaps = 106/632 (16%)
Query: 142 QGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQ 201
QG + ++ + K Q EL K ++ LR + + + +L+ ++
Sbjct: 1236 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1295
Query: 202 QHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQV 261
+ L H + V +E + +A L R ++ Q+ + Q+
Sbjct: 1296 VGERLQQRHGERDVEVERWRERVA-------------QLLERWQAVLAQTDVRQRELEQL 1342
Query: 262 AHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPI 321
+ Y + + +Q+ R + Q +A +L + QA E I
Sbjct: 1343 GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-------RQEQALLEEI 1395
Query: 322 QQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREA 381
++ E+ E E + +++ A+++ E++ V LE P+ + + + E Q E
Sbjct: 1396 ERHGEKVE-ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EY 1453
Query: 382 ANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQ-RLAVQQ-VEEAQQLREHQEALH---- 435
+L ++ E+ IKF S ++E++ RLA QQ EE ++L E + AL
Sbjct: 1454 VDLRTHYS--ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1511
Query: 436 -------------------QQRLQGHLLRQQE------QQQQQVAREM------------ 458
QQR+Q ++R++E QQ++ + E+
Sbjct: 1512 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1571
Query: 459 ALQRQAE-LEEGRPQHQEQLR--------QQAHYDAMDNDI------VQGAEDQGIQGEE 503
A RQAE E R + +E++R + + ++ + AE Q Q +E
Sbjct: 1572 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1631
Query: 504 GAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRA--AVEDI----NPADDPNNQ 557
A Q QDE++ E + EA+ E RA A+E++ A+ Q
Sbjct: 1632 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1691
Query: 558 GEDE--------FEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNV 609
E E E A++ E L + + + E + EEH+ +A ++ E
Sbjct: 1692 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1751
Query: 610 DEQYQ-----EEAEEEVQE-DLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDD 663
+Q + EEAE E++ L + L AEE + + EE E
Sbjct: 1752 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1811
Query: 664 NRPKGREEHYEEEEEEEEDGAAVAEKSHRRAE 695
R K E+ + E E++ EK + AE
Sbjct: 1812 RRGKAEEQAVRQRELAEQE----LEKQRQLAE 1839
Score = 54.7 bits (130), Expect = 3e-07
Identities = 79/346 (22%), Positives = 147/346 (42%), Gaps = 54/346 (15%)
Query: 42 KAEAV--ALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQET 99
K +AV A + + E L Q ++ E RL++ KE++ + A+E Q T
Sbjct: 2452 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQED--KEQMAQQLAEET-----QGFQRT 2504
Query: 100 LNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEE---HRKQ----GEDFSRTFND 152
L RQ R ++ + + LK + E+ + + EE+ RKQ GE RT
Sbjct: 2505 LEAERQ----RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2560
Query: 153 HKQKYLQLQ------QEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQ-QHKN 205
++K +Q Q+ + + +L+E + L E +L++ + + + ++++ Q +
Sbjct: 2561 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2620
Query: 206 LLSEHEQLVVTLEDHKSALAAAQTQVAEYKQ-----LKDTLNRIPSLRKPDPAEQQNVTQ 260
LL E + L + K +L + + + K +D + + LR+ +QQ + Q
Sbjct: 2621 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680
Query: 261 VAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPG-RAEDTKLYAPTHKEAEFQAPPE 319
R++ ++E R + HEA G R + +L E + + E
Sbjct: 2681 ----------ERQRLVASMEEARR-----RQHEAEEGVRRKQEELQ---QLEQQRRQQEE 2722
Query: 320 PIQQEVERREPEEHQVEEEHRKAL---EEEEMEQVGQAEHLEEEHD 362
+ +E +R + +EE+HR AL EE QV + L D
Sbjct: 2723 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2768
Score = 50.8 bits (120), Expect = 4e-06
Identities = 64/262 (24%), Positives = 118/262 (45%), Gaps = 41/262 (15%)
Query: 30 AMLYYELQTQLRKAEAVALKYQQ----HQESLSAQLQVVYEH-RSRLEKSLQKER-LEHK 83
A L E + ++A+ + LK ++ QE L + Q + + S + LQ+ER +E +
Sbjct: 2590 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2649
Query: 84 KAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQG 143
KAK + L A+ + R++ + + + Q L + EE +++ + EE R++
Sbjct: 2650 KAKLEQLFQDEVAKA--QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2707
Query: 144 EDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
E+ QL+Q++ Q+ L EEN++LR+ QLQ +++QH
Sbjct: 2708 EELQ-----------QLEQQRRQQEEL-------LAEENQRLRE-------QLQLLEEQH 2742
Query: 204 KNLLSEHEQLVV-------TLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQ 256
+ L+ E++ TL + + AL + AE + D L R S ++ A
Sbjct: 2743 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAE-AEPEHSFDGLRRKVSAQRLQEAGIL 2801
Query: 257 NVTQVAHSPQGYNTAREKPTRE 278
+ ++ QG+ T E RE
Sbjct: 2802 SAEELQRLAQGHTTVDELARRE 2823
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 95.5 bits (236), Expect = 1e-19
Identities = 159/750 (21%), Positives = 313/750 (41%), Gaps = 111/750 (14%)
Query: 39 QLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERL-EHKKAKEDFLVYKL--- 94
Q R+ E A +++ E AQL+ + +K L ++ L + ++ +E+ L K
Sbjct: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1913
Query: 95 -----EAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRT 149
+A+ L GR SN+ + + + L++ + +Q + EE R++ E+ +
Sbjct: 1914 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ---RQLAAEEERRRREAEERVQK 1970
Query: 150 FNDHKQKYLQLQQEKEQELSKLKETVYNLR--------EENRQLRKAHQDIHTQLQDVKQ 201
+++ + ++ +E+ +LK V R E RQL+ A + +LQ ++
Sbjct: 1971 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2030
Query: 202 QHKNLLSEHEQ-LVVTLEDHKSAL---------AAAQTQVAEYKQLKDTLNRIPSLRKPD 251
H + + EQ L TL+ +S L A + AE +++ S R+ +
Sbjct: 2031 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2090
Query: 252 PAEQ--QNVTQVAHSPQGYNTAREKPTREV-QEVSRNNDVWQ----NHEAVPGRAEDTKL 304
AE+ Q+ + A + A EK +E QE +R Q +A E K
Sbjct: 2091 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2150
Query: 305 YAPT--HKEAEFQAPPEPIQQEVERREPEEHQVEEE-------------HRKALEEE--- 346
+A ++A+ + ++ ++E + +++ ++EE R +EEE
Sbjct: 2151 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2210
Query: 347 ---EMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLE-GHARAEVYPSAKPMIK 402
+ME++ + + E + + +D++ ++ Q EA + + A + +A+ +
Sbjct: 2211 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2270
Query: 403 FQSPYEEQLEQQRLA--------VQQVEEAQQLREHQEALHQQR-LQGHLLRQQEQQQQQ 453
+ EE L QQR +Q V+EA +L+ E L QQ+ L R+ ++ ++Q
Sbjct: 2271 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2330
Query: 454 VAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQ 513
+A+++A + Q + Q QL A + + + + + Q E+ R Q
Sbjct: 2331 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK---Q 2387
Query: 514 DEAEGDPGNRHEPREQGP-----------READPESEADRAAVEDINPADDPNNQGED-- 560
E G+ +R E Q +++D ++E R A+ ++ + Q
Sbjct: 2388 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2447
Query: 561 --EFEEAEQVREENLPDENEEQKQS--NQK-----------QENTEVEEHLVMAGNPDQQ 605
+ EE + V++E L E + +QS ++K QE ++E+ QQ
Sbjct: 2448 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2507
Query: 606 EDNVDEQYQEEAEEEVQEDLTE-EKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDN 664
++ Q++ E+E Q + E+ R +H AEE E E Q++
Sbjct: 2508 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---------ELQQLEQQR 2558
Query: 665 RPKGREEHYEEEEEEEEDGAAVAEKSHRRA 694
R +EE EE + + + E+ HR A
Sbjct: 2559 RQ--QEELLAEENQRLREQLQLLEEQHRAA 2586
Score = 86.3 bits (212), Expect = 9e-17
Identities = 117/482 (24%), Positives = 214/482 (44%), Gaps = 65/482 (13%)
Query: 35 ELQTQLR-KAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYK 93
E Q Q R +A+A A K ++ E +A+ + R +++ E +HKK E L K
Sbjct: 2100 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2159
Query: 94 LEAQETLNKGR---QDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEH---RKQGEDFS 147
+ ++ L R ++++ + + L+ + Q LK++ E +Q S +EEE R Q E+ S
Sbjct: 2160 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2219
Query: 148 RTF--------------NDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIH 193
+ D+ Q++LQ + EK +++++ + +E +LR+ ++
Sbjct: 2220 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2277
Query: 194 TQLQDVKQQH---KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKP 250
D+ QQ + +L E Q V + L A + + K+L R+
Sbjct: 2278 ----DLAQQRALAEKMLKEKMQAV----QEATRLKAEAELLQQQKELAQE-----QARRL 2324
Query: 251 DPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHK 310
++Q Q+A QG+ E + E+S + + A RA+ A +
Sbjct: 2325 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ-----ARAEE 2379
Query: 311 EAE-FQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEE---EHDPSPE 366
+A+ F+ E I +++ R E Q + + LE + + AE L E E + E
Sbjct: 2380 DAQRFRKQAEEIGEKLHRTELAT-QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2438
Query: 367 EQDREWK-------EQHEQREAANLLEGHARAEVYPSAKPMIKFQSPY--EEQLEQQRLA 417
+ +E K E ++ L E A + + S K + + + +E+ + ++L
Sbjct: 2439 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2498
Query: 418 VQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQL 477
+V +AQQLRE Q+ QQ +QE+Q+ + E A +RQ E EEG + QE+L
Sbjct: 2499 QDEVAKAQQLREEQQRQQQQM-------EQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2551
Query: 478 RQ 479
+Q
Sbjct: 2552 QQ 2553
Score = 80.5 bits (197), Expect = 5e-15
Identities = 154/754 (20%), Positives = 291/754 (38%), Gaps = 110/754 (14%)
Query: 35 ELQTQLRKAEAVA---LKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLV 91
E+Q + R+AEA L+ ++ + QL+ R E LQ R ++A+
Sbjct: 1410 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1469
Query: 92 YKLEAQETLNKGRQDSNSRYSALNVQ-HQMLKSQHEELKKQHSDLE--EEHRKQGEDFSR 148
+ EA E L + QD + R V+ +K++ E +++ L+ EE R Q E+ R
Sbjct: 1470 AQEEA-ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1528
Query: 149 TFNDH-----KQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
+Q + L+ + ++L+ + E+ QL ++ Q+ H + ++++
Sbjct: 1529 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1588
Query: 204 KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH 263
+ + + E+ + L Q + E +L+ L+ + A+Q+++ Q
Sbjct: 1589 ERRAQQQAEAERAREEAERELERWQLKANEALRLR--------LQAEEVAQQKSLAQAEA 1640
Query: 264 SPQGYNTARE----------------------KPTREVQEVSRNNDVWQNHEAVPGRAE- 300
Q RE + R++ E + + E + RAE
Sbjct: 1641 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1700
Query: 301 -----------------DTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKAL 343
+ A T K E +A ++ E+E + + EEE R
Sbjct: 1701 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1760
Query: 344 EEEEME---QVGQAEHLEEEHD-----PSPEEQDREWKEQHEQREAANLLEGHARAEVYP 395
E+ + + G+ L EE ++ R+ E+ R+ A A
Sbjct: 1761 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1820
Query: 396 SAKPMIKFQSPY---EEQLEQQRLAVQQVEEAQQLR--EHQEALHQQRLQGHLLRQQEQQ 450
+K ++ E++ E +RL +EA Q R E Q A H+ ++ L + ++
Sbjct: 1821 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1880
Query: 451 QQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMD----------NDIVQGAEDQGIQ 500
++ R+ L L + R +E L +A ++ I AED
Sbjct: 1881 DSELERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1939
Query: 501 GEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADR---AAVEDINPADDPNNQ 557
E+ E Q Q AE + R E E+ + E EA R AA+E++
Sbjct: 1940 KEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEVERL------ 1992
Query: 558 GEDEFEEAEQVREENLPDENEE---QKQSNQKQENTEVEEHLVMAGNPD-------QQED 607
+ + EEA ++RE + + +++ QK+ E + H + QQE
Sbjct: 1993 -KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2051
Query: 608 NVDEQYQEEAEEEVQ-EDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRP 666
+V +Q + EAE + + EE + + E A ++ + +E K + E+ + R +
Sbjct: 2052 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2111
Query: 667 KGREEHYEEEEE----EEEDGAAVAEKSHRRAEM 696
+ E E+E + + AA+ +K AEM
Sbjct: 2112 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2145
Score = 76.3 bits (186), Expect = 9e-14
Identities = 139/679 (20%), Positives = 259/679 (38%), Gaps = 61/679 (8%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRL---------EKSLQKERLEHKKA 85
E + Q + AE A + + E + A+ +RL EK + ERL
Sbjct: 1790 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1849
Query: 86 KEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEE--EHRKQG 143
E F +LE Q +K D R + Q+ K+ EL++Q +E+ R+Q
Sbjct: 1850 DEAFQRRRLEEQAAQHKA--DIEERLA------QLRKASDSELERQKGLVEDTLRQRRQV 1901
Query: 144 EDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
E+ +K + E E EL +++ N + R +A + Q Q ++
Sbjct: 1902 EEEILALKASFEKAAAGKAELELELGRIRS---NAEDTLRSKEQAELEAARQRQLAAEEE 1958
Query: 204 KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH 263
+ E++ +L + A + + E ++LK + LR+ E Q+A
Sbjct: 1959 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2018
Query: 264 SPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQ 323
E+ + ++ Q + + + A + A +A +Q
Sbjct: 2019 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2078
Query: 324 EVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAAN 383
E E + E E K EE+ + QA+ E+ +E ++E + + +AA
Sbjct: 2079 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK---LRKEAEQEAARRAQAEQAAL 2135
Query: 384 LLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLR-EHQEALHQQRLQGH 442
+ A AE+ K + EQ +Q+ V+Q E LR + +E HQ+ L
Sbjct: 2136 RQKQAADAEMEKHKK--------FAEQTLRQKAQVEQ--ELTTLRLQLEETDHQKNLLDE 2185
Query: 443 LLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGE 502
L++ + + + AR+ + Q + EL R Q +E + +A +A + ++ +D +
Sbjct: 2186 ELQRLKAEATEAARQRS-QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2244
Query: 503 EGAYERDNQHQDE-----------------AEGDPGNRHEPREQGPRE-ADPESEADRAA 544
+ E+ Q +E AE D + E+ +E EA R
Sbjct: 2245 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2304
Query: 545 VEDINPADDPNNQGEDEFEEAEQVRE--ENLPDENEEQKQSNQKQENTEVEEHLVMAGNP 602
E A+ Q E E+A +++E E + + E+ Q Q+ E + L M+
Sbjct: 2305 AE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2360
Query: 603 DQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRD 662
++ + V E + +A E ++ E+ T E +++ D
Sbjct: 2361 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2420
Query: 663 DNRPKGREEHYEEEEEEEE 681
+ + RE E E E+E+
Sbjct: 2421 HDAERLREAIAELEREKEK 2439
Score = 71.6 bits (174), Expect = 2e-12
Identities = 97/435 (22%), Positives = 185/435 (42%), Gaps = 38/435 (8%)
Query: 31 MLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKER----LEHKKAK 86
+L ELQ +A A + Q +E L + ++V E S+L+ ++ E L K
Sbjct: 2182 LLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKLKARIEAENRALILRDKDNT 2240
Query: 87 EDFLVYKLEAQETLNKGRQ--DSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGE 144
+ FL QE K +Q + +R S + L+ EE Q L E+ K+
Sbjct: 2241 QRFL------QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2294
Query: 145 DFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHK 204
+ K + LQQ+KE + + + + +QL + Q L+ +Q+
Sbjct: 2295 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2354
Query: 205 NLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH- 263
+ +E E+L + + + A A A+ +++ + + L + + A Q+ VT V
Sbjct: 2355 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE--KLHRTELATQEKVTLVQTL 2412
Query: 264 --SPQGYNTAREKPTREVQEVSRNND-VWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEP 320
Q + E+ + E+ R + + Q + + ++E+ + E QA +
Sbjct: 2413 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2472
Query: 321 IQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQRE 380
E + E +E+E K LE+ ++V +A+ L EE +++ ++ EQ QR
Sbjct: 2473 FLSEKDSLLQRERFIEQEKAK-LEQLFQDEVAKAQQLREE-----QQRQQQQMEQERQRL 2526
Query: 381 AANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQ 440
A++ E R Q EE + +++ +QQ+E+ ++ +E A QRL+
Sbjct: 2527 VASMEEARRR-------------QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2573
Query: 441 GHLLRQQEQQQQQVA 455
L +EQ + +A
Sbjct: 2574 EQLQLLEEQHRAALA 2588
Score = 64.3 bits (155), Expect = 4e-10
Identities = 154/727 (21%), Positives = 293/727 (40%), Gaps = 103/727 (14%)
Query: 43 AEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDF----LVYKLEAQE 98
A++ A++ Q QE A L+ + H ++E+ Q+ ++ A +D+ + YK + +
Sbjct: 1217 ADSQAVREQLRQEQ--ALLEEIERHGEKVEEC-QRFAKQYINAIKDYELQLVTYKAQLEP 1273
Query: 99 TLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYL 158
+ ++ S +Q ++ +L+ +S+L + + S T +++
Sbjct: 1274 VASPAKKPKVQSGSESVIQ------EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1327
Query: 159 QLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQ--------------------- 197
+Q++ +E +L E L E+ RQL +AH Q +
Sbjct: 1328 LAEQQRAEERERLAEVEAAL-EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1386
Query: 198 -DVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLK-DTLNRIPSL------RK 249
D +QQ +++ E +QL + E A A Q + AE +L+ + R+ L R+
Sbjct: 1387 VDAQQQKRSIQEELQQLRQSSEAEIQA-KARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1445
Query: 250 PDPAEQQNVTQVAHSPQGYNTAR------EKPTREVQEVSRNNDVWQ-------NHEAVP 296
AE + A + + R E+ R+VQ+ S+ + EA
Sbjct: 1446 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1505
Query: 297 GRAEDTKLYAPTHKEAEFQAPPEPIQQ-EVERREPEEHQVEEEHRKALEEEEMEQVGQAE 355
R + L A + + ++Q EVER + +E R A E + ++ AE
Sbjct: 1506 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1565
Query: 356 H-------LEEEHDPSPEEQDREWKEQHEQREAANLLEGHARA--EVYPSAKPMIKFQSP 406
L+EEH + ++ + +Q EA E R A ++ +
Sbjct: 1566 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1625
Query: 407 YEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAEL 466
EE +Q+ LA + E+ ++ E +EA + + + +RQ+E +Q+ L++Q +L
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAE-REARRRGKAEEQAVRQRELAEQE------LEKQRQL 1678
Query: 467 EEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGA-YERD----NQHQDEAEGDPG 521
EG Q++L + + + QG + + + EE A +R+ Q + E E +
Sbjct: 1679 AEGTA--QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1736
Query: 522 N-RHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQ 580
R E +A E E+ + + + + + EEA ++R L +E + Q
Sbjct: 1737 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA--LAEEAKRQ 1794
Query: 581 KQ------SNQKQENTEV-EEHLVMAGNPDQQEDNVDEQYQE-EAEEEVQEDLTEE---K 629
+Q + Q+ E V E L G + + + +E EAE E L E+ +
Sbjct: 1795 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1854
Query: 630 KRELEHNAEETYGENDENTDD--KNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVA 687
+R LE A + + +E K +D E + R KG E + + E+
Sbjct: 1855 RRRLEEQAAQHKADIEERLAQLRKASDSELE------RQKGLVEDTLRQRRQVEEEILAL 1908
Query: 688 EKSHRRA 694
+ S +A
Sbjct: 1909 KASFEKA 1915
Score = 59.7 bits (143), Expect = 9e-09
Identities = 132/632 (20%), Positives = 240/632 (37%), Gaps = 106/632 (16%)
Query: 142 QGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQ 201
QG + ++ + K Q EL K ++ LR + + + +L+ ++
Sbjct: 1077 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1136
Query: 202 QHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQV 261
+ L H + V +E + +A L R ++ Q+ + Q+
Sbjct: 1137 VGERLQQRHGERDVEVERWRERVA-------------QLLERWQAVLAQTDVRQRELEQL 1183
Query: 262 AHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPI 321
+ Y + + +Q+ R + Q +A +L + QA E I
Sbjct: 1184 GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-------RQEQALLEEI 1236
Query: 322 QQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREA 381
++ E+ E E + +++ A+++ E++ V LE P+ + + + E Q E
Sbjct: 1237 ERHGEKVE-ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EY 1294
Query: 382 ANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQ-RLAVQQ-VEEAQQLREHQEALH---- 435
+L ++ E+ IKF S ++E++ RLA QQ EE ++L E + AL
Sbjct: 1295 VDLRTHYS--ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1352
Query: 436 -------------------QQRLQGHLLRQQE------QQQQQVAREM------------ 458
QQR+Q ++R++E QQ++ + E+
Sbjct: 1353 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1412
Query: 459 ALQRQAE-LEEGRPQHQEQLR--------QQAHYDAMDNDI------VQGAEDQGIQGEE 503
A RQAE E R + +E++R + + ++ + AE Q Q +E
Sbjct: 1413 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1472
Query: 504 GAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRA--AVEDI----NPADDPNNQ 557
A Q QDE++ E + EA+ E RA A+E++ A+ Q
Sbjct: 1473 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1532
Query: 558 GEDE--------FEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNV 609
E E E A++ E L + + + E + EEH+ +A ++ E
Sbjct: 1533 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1592
Query: 610 DEQYQ-----EEAEEEVQE-DLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDD 663
+Q + EEAE E++ L + L AEE + + EE E
Sbjct: 1593 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1652
Query: 664 NRPKGREEHYEEEEEEEEDGAAVAEKSHRRAE 695
R K E+ + E E++ EK + AE
Sbjct: 1653 RRGKAEEQAVRQRELAEQE----LEKQRQLAE 1680
Score = 54.7 bits (130), Expect = 3e-07
Identities = 79/346 (22%), Positives = 147/346 (42%), Gaps = 54/346 (15%)
Query: 42 KAEAV--ALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQET 99
K +AV A + + E L Q ++ E RL++ KE++ + A+E Q T
Sbjct: 2293 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQED--KEQMAQQLAEET-----QGFQRT 2345
Query: 100 LNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEE---HRKQ----GEDFSRTFND 152
L RQ R ++ + + LK + E+ + + EE+ RKQ GE RT
Sbjct: 2346 LEAERQ----RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2401
Query: 153 HKQKYLQLQ------QEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQ-QHKN 205
++K +Q Q+ + + +L+E + L E +L++ + + + ++++ Q +
Sbjct: 2402 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2461
Query: 206 LLSEHEQLVVTLEDHKSALAAAQTQVAEYKQ-----LKDTLNRIPSLRKPDPAEQQNVTQ 260
LL E + L + K +L + + + K +D + + LR+ +QQ + Q
Sbjct: 2462 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521
Query: 261 VAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPG-RAEDTKLYAPTHKEAEFQAPPE 319
R++ ++E R + HEA G R + +L E + + E
Sbjct: 2522 ----------ERQRLVASMEEARR-----RQHEAEEGVRRKQEELQ---QLEQQRRQQEE 2563
Query: 320 PIQQEVERREPEEHQVEEEHRKAL---EEEEMEQVGQAEHLEEEHD 362
+ +E +R + +EE+HR AL EE QV + L D
Sbjct: 2564 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2609
Score = 50.8 bits (120), Expect = 4e-06
Identities = 64/262 (24%), Positives = 118/262 (45%), Gaps = 41/262 (15%)
Query: 30 AMLYYELQTQLRKAEAVALKYQQ----HQESLSAQLQVVYEH-RSRLEKSLQKER-LEHK 83
A L E + ++A+ + LK ++ QE L + Q + + S + LQ+ER +E +
Sbjct: 2431 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2490
Query: 84 KAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQG 143
KAK + L A+ + R++ + + + Q L + EE +++ + EE R++
Sbjct: 2491 KAKLEQLFQDEVAKA--QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2548
Query: 144 EDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
E+ QL+Q++ Q+ L EEN++LR+ QLQ +++QH
Sbjct: 2549 EELQ-----------QLEQQRRQQEEL-------LAEENQRLRE-------QLQLLEEQH 2583
Query: 204 KNLLSEHEQLVV-------TLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQ 256
+ L+ E++ TL + + AL + AE + D L R S ++ A
Sbjct: 2584 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAE-AEPEHSFDGLRRKVSAQRLQEAGIL 2642
Query: 257 NVTQVAHSPQGYNTAREKPTRE 278
+ ++ QG+ T E RE
Sbjct: 2643 SAEELQRLAQGHTTVDELARRE 2664
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 95.5 bits (236), Expect = 1e-19
Identities = 159/750 (21%), Positives = 313/750 (41%), Gaps = 111/750 (14%)
Query: 39 QLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERL-EHKKAKEDFLVYKL--- 94
Q R+ E A +++ E AQL+ + +K L ++ L + ++ +E+ L K
Sbjct: 1862 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1921
Query: 95 -----EAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRT 149
+A+ L GR SN+ + + + L++ + +Q + EE R++ E+ +
Sbjct: 1922 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ---RQLAAEEERRRREAEERVQK 1978
Query: 150 FNDHKQKYLQLQQEKEQELSKLKETVYNLR--------EENRQLRKAHQDIHTQLQDVKQ 201
+++ + ++ +E+ +LK V R E RQL+ A + +LQ ++
Sbjct: 1979 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2038
Query: 202 QHKNLLSEHEQ-LVVTLEDHKSAL---------AAAQTQVAEYKQLKDTLNRIPSLRKPD 251
H + + EQ L TL+ +S L A + AE +++ S R+ +
Sbjct: 2039 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2098
Query: 252 PAEQ--QNVTQVAHSPQGYNTAREKPTREV-QEVSRNNDVWQ----NHEAVPGRAEDTKL 304
AE+ Q+ + A + A EK +E QE +R Q +A E K
Sbjct: 2099 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2158
Query: 305 YAPT--HKEAEFQAPPEPIQQEVERREPEEHQVEEE-------------HRKALEEE--- 346
+A ++A+ + ++ ++E + +++ ++EE R +EEE
Sbjct: 2159 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2218
Query: 347 ---EMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLE-GHARAEVYPSAKPMIK 402
+ME++ + + E + + +D++ ++ Q EA + + A + +A+ +
Sbjct: 2219 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2278
Query: 403 FQSPYEEQLEQQRLA--------VQQVEEAQQLREHQEALHQQR-LQGHLLRQQEQQQQQ 453
+ EE L QQR +Q V+EA +L+ E L QQ+ L R+ ++ ++Q
Sbjct: 2279 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2338
Query: 454 VAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQ 513
+A+++A + Q + Q QL A + + + + + Q E+ R Q
Sbjct: 2339 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK---Q 2395
Query: 514 DEAEGDPGNRHEPREQGP-----------READPESEADRAAVEDINPADDPNNQGED-- 560
E G+ +R E Q +++D ++E R A+ ++ + Q
Sbjct: 2396 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2455
Query: 561 --EFEEAEQVREENLPDENEEQKQS--NQK-----------QENTEVEEHLVMAGNPDQQ 605
+ EE + V++E L E + +QS ++K QE ++E+ QQ
Sbjct: 2456 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2515
Query: 606 EDNVDEQYQEEAEEEVQEDLTE-EKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDN 664
++ Q++ E+E Q + E+ R +H AEE E E Q++
Sbjct: 2516 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---------ELQQLEQQR 2566
Query: 665 RPKGREEHYEEEEEEEEDGAAVAEKSHRRA 694
R +EE EE + + + E+ HR A
Sbjct: 2567 RQ--QEELLAEENQRLREQLQLLEEQHRAA 2594
Score = 86.3 bits (212), Expect = 9e-17
Identities = 117/482 (24%), Positives = 214/482 (44%), Gaps = 65/482 (13%)
Query: 35 ELQTQLR-KAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYK 93
E Q Q R +A+A A K ++ E +A+ + R +++ E +HKK E L K
Sbjct: 2108 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2167
Query: 94 LEAQETLNKGR---QDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEH---RKQGEDFS 147
+ ++ L R ++++ + + L+ + Q LK++ E +Q S +EEE R Q E+ S
Sbjct: 2168 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2227
Query: 148 RTF--------------NDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIH 193
+ D+ Q++LQ + EK +++++ + +E +LR+ ++
Sbjct: 2228 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2285
Query: 194 TQLQDVKQQH---KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKP 250
D+ QQ + +L E Q V + L A + + K+L R+
Sbjct: 2286 ----DLAQQRALAEKMLKEKMQAV----QEATRLKAEAELLQQQKELAQE-----QARRL 2332
Query: 251 DPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHK 310
++Q Q+A QG+ E + E+S + + A RA+ A +
Sbjct: 2333 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ-----ARAEE 2387
Query: 311 EAE-FQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEE---EHDPSPE 366
+A+ F+ E I +++ R E Q + + LE + + AE L E E + E
Sbjct: 2388 DAQRFRKQAEEIGEKLHRTELAT-QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2446
Query: 367 EQDREWK-------EQHEQREAANLLEGHARAEVYPSAKPMIKFQSPY--EEQLEQQRLA 417
+ +E K E ++ L E A + + S K + + + +E+ + ++L
Sbjct: 2447 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2506
Query: 418 VQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQL 477
+V +AQQLRE Q+ QQ +QE+Q+ + E A +RQ E EEG + QE+L
Sbjct: 2507 QDEVAKAQQLREEQQRQQQQM-------EQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2559
Query: 478 RQ 479
+Q
Sbjct: 2560 QQ 2561
Score = 80.5 bits (197), Expect = 5e-15
Identities = 154/754 (20%), Positives = 291/754 (38%), Gaps = 110/754 (14%)
Query: 35 ELQTQLRKAEAVA---LKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLV 91
E+Q + R+AEA L+ ++ + QL+ R E LQ R ++A+
Sbjct: 1418 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1477
Query: 92 YKLEAQETLNKGRQDSNSRYSALNVQ-HQMLKSQHEELKKQHSDLE--EEHRKQGEDFSR 148
+ EA E L + QD + R V+ +K++ E +++ L+ EE R Q E+ R
Sbjct: 1478 AQEEA-ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1536
Query: 149 TFNDH-----KQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
+Q + L+ + ++L+ + E+ QL ++ Q+ H + ++++
Sbjct: 1537 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1596
Query: 204 KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH 263
+ + + E+ + L Q + E +L+ L+ + A+Q+++ Q
Sbjct: 1597 ERRAQQQAEAERAREEAERELERWQLKANEALRLR--------LQAEEVAQQKSLAQAEA 1648
Query: 264 SPQGYNTARE----------------------KPTREVQEVSRNNDVWQNHEAVPGRAE- 300
Q RE + R++ E + + E + RAE
Sbjct: 1649 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1708
Query: 301 -----------------DTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKAL 343
+ A T K E +A ++ E+E + + EEE R
Sbjct: 1709 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1768
Query: 344 EEEEME---QVGQAEHLEEEHD-----PSPEEQDREWKEQHEQREAANLLEGHARAEVYP 395
E+ + + G+ L EE ++ R+ E+ R+ A A
Sbjct: 1769 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1828
Query: 396 SAKPMIKFQSPY---EEQLEQQRLAVQQVEEAQQLR--EHQEALHQQRLQGHLLRQQEQQ 450
+K ++ E++ E +RL +EA Q R E Q A H+ ++ L + ++
Sbjct: 1829 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1888
Query: 451 QQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMD----------NDIVQGAEDQGIQ 500
++ R+ L L + R +E L +A ++ I AED
Sbjct: 1889 DSELERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1947
Query: 501 GEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADR---AAVEDINPADDPNNQ 557
E+ E Q Q AE + R E E+ + E EA R AA+E++
Sbjct: 1948 KEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEVERL------ 2000
Query: 558 GEDEFEEAEQVREENLPDENEE---QKQSNQKQENTEVEEHLVMAGNPD-------QQED 607
+ + EEA ++RE + + +++ QK+ E + H + QQE
Sbjct: 2001 -KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2059
Query: 608 NVDEQYQEEAEEEVQ-EDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRP 666
+V +Q + EAE + + EE + + E A ++ + +E K + E+ + R +
Sbjct: 2060 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2119
Query: 667 KGREEHYEEEEE----EEEDGAAVAEKSHRRAEM 696
+ E E+E + + AA+ +K AEM
Sbjct: 2120 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2153
Score = 76.3 bits (186), Expect = 9e-14
Identities = 139/679 (20%), Positives = 259/679 (38%), Gaps = 61/679 (8%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRL---------EKSLQKERLEHKKA 85
E + Q + AE A + + E + A+ +RL EK + ERL
Sbjct: 1798 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1857
Query: 86 KEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEE--EHRKQG 143
E F +LE Q +K D R + Q+ K+ EL++Q +E+ R+Q
Sbjct: 1858 DEAFQRRRLEEQAAQHKA--DIEERLA------QLRKASDSELERQKGLVEDTLRQRRQV 1909
Query: 144 EDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
E+ +K + E E EL +++ N + R +A + Q Q ++
Sbjct: 1910 EEEILALKASFEKAAAGKAELELELGRIRS---NAEDTLRSKEQAELEAARQRQLAAEEE 1966
Query: 204 KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH 263
+ E++ +L + A + + E ++LK + LR+ E Q+A
Sbjct: 1967 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2026
Query: 264 SPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQ 323
E+ + ++ Q + + + A + A +A +Q
Sbjct: 2027 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2086
Query: 324 EVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAAN 383
E E + E E K EE+ + QA+ E+ +E ++E + + +AA
Sbjct: 2087 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK---LRKEAEQEAARRAQAEQAAL 2143
Query: 384 LLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLR-EHQEALHQQRLQGH 442
+ A AE+ K + EQ +Q+ V+Q E LR + +E HQ+ L
Sbjct: 2144 RQKQAADAEMEKHKK--------FAEQTLRQKAQVEQ--ELTTLRLQLEETDHQKNLLDE 2193
Query: 443 LLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGE 502
L++ + + + AR+ + Q + EL R Q +E + +A +A + ++ +D +
Sbjct: 2194 ELQRLKAEATEAARQRS-QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2252
Query: 503 EGAYERDNQHQDE-----------------AEGDPGNRHEPREQGPRE-ADPESEADRAA 544
+ E+ Q +E AE D + E+ +E EA R
Sbjct: 2253 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2312
Query: 545 VEDINPADDPNNQGEDEFEEAEQVRE--ENLPDENEEQKQSNQKQENTEVEEHLVMAGNP 602
E A+ Q E E+A +++E E + + E+ Q Q+ E + L M+
Sbjct: 2313 AE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2368
Query: 603 DQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRD 662
++ + V E + +A E ++ E+ T E +++ D
Sbjct: 2369 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2428
Query: 663 DNRPKGREEHYEEEEEEEE 681
+ + RE E E E+E+
Sbjct: 2429 HDAERLREAIAELEREKEK 2447
Score = 71.6 bits (174), Expect = 2e-12
Identities = 97/435 (22%), Positives = 185/435 (42%), Gaps = 38/435 (8%)
Query: 31 MLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKER----LEHKKAK 86
+L ELQ +A A + Q +E L + ++V E S+L+ ++ E L K
Sbjct: 2190 LLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKLKARIEAENRALILRDKDNT 2248
Query: 87 EDFLVYKLEAQETLNKGRQ--DSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGE 144
+ FL QE K +Q + +R S + L+ EE Q L E+ K+
Sbjct: 2249 QRFL------QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2302
Query: 145 DFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHK 204
+ K + LQQ+KE + + + + +QL + Q L+ +Q+
Sbjct: 2303 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2362
Query: 205 NLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH- 263
+ +E E+L + + + A A A+ +++ + + L + + A Q+ VT V
Sbjct: 2363 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE--KLHRTELATQEKVTLVQTL 2420
Query: 264 --SPQGYNTAREKPTREVQEVSRNND-VWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEP 320
Q + E+ + E+ R + + Q + + ++E+ + E QA +
Sbjct: 2421 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2480
Query: 321 IQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQRE 380
E + E +E+E K LE+ ++V +A+ L EE +++ ++ EQ QR
Sbjct: 2481 FLSEKDSLLQRERFIEQEKAK-LEQLFQDEVAKAQQLREE-----QQRQQQQMEQERQRL 2534
Query: 381 AANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQ 440
A++ E R Q EE + +++ +QQ+E+ ++ +E A QRL+
Sbjct: 2535 VASMEEARRR-------------QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2581
Query: 441 GHLLRQQEQQQQQVA 455
L +EQ + +A
Sbjct: 2582 EQLQLLEEQHRAALA 2596
Score = 64.3 bits (155), Expect = 4e-10
Identities = 154/727 (21%), Positives = 293/727 (40%), Gaps = 103/727 (14%)
Query: 43 AEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDF----LVYKLEAQE 98
A++ A++ Q QE A L+ + H ++E+ Q+ ++ A +D+ + YK + +
Sbjct: 1225 ADSQAVREQLRQEQ--ALLEEIERHGEKVEEC-QRFAKQYINAIKDYELQLVTYKAQLEP 1281
Query: 99 TLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYL 158
+ ++ S +Q ++ +L+ +S+L + + S T +++
Sbjct: 1282 VASPAKKPKVQSGSESVIQ------EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1335
Query: 159 QLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQ--------------------- 197
+Q++ +E +L E L E+ RQL +AH Q +
Sbjct: 1336 LAEQQRAEERERLAEVEAAL-EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1394
Query: 198 -DVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLK-DTLNRIPSL------RK 249
D +QQ +++ E +QL + E A A Q + AE +L+ + R+ L R+
Sbjct: 1395 VDAQQQKRSIQEELQQLRQSSEAEIQA-KARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1453
Query: 250 PDPAEQQNVTQVAHSPQGYNTAR------EKPTREVQEVSRNNDVWQ-------NHEAVP 296
AE + A + + R E+ R+VQ+ S+ + EA
Sbjct: 1454 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1513
Query: 297 GRAEDTKLYAPTHKEAEFQAPPEPIQQ-EVERREPEEHQVEEEHRKALEEEEMEQVGQAE 355
R + L A + + ++Q EVER + +E R A E + ++ AE
Sbjct: 1514 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1573
Query: 356 H-------LEEEHDPSPEEQDREWKEQHEQREAANLLEGHARA--EVYPSAKPMIKFQSP 406
L+EEH + ++ + +Q EA E R A ++ +
Sbjct: 1574 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1633
Query: 407 YEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAEL 466
EE +Q+ LA + E+ ++ E +EA + + + +RQ+E +Q+ L++Q +L
Sbjct: 1634 AEEVAQQKSLAQAEAEKQKEEAE-REARRRGKAEEQAVRQRELAEQE------LEKQRQL 1686
Query: 467 EEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGA-YERD----NQHQDEAEGDPG 521
EG Q++L + + + QG + + + EE A +R+ Q + E E +
Sbjct: 1687 AEGTA--QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1744
Query: 522 N-RHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQ 580
R E +A E E+ + + + + + EEA ++R L +E + Q
Sbjct: 1745 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA--LAEEAKRQ 1802
Query: 581 KQ------SNQKQENTEV-EEHLVMAGNPDQQEDNVDEQYQE-EAEEEVQEDLTEE---K 629
+Q + Q+ E V E L G + + + +E EAE E L E+ +
Sbjct: 1803 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1862
Query: 630 KRELEHNAEETYGENDENTDD--KNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVA 687
+R LE A + + +E K +D E + R KG E + + E+
Sbjct: 1863 RRRLEEQAAQHKADIEERLAQLRKASDSELE------RQKGLVEDTLRQRRQVEEEILAL 1916
Query: 688 EKSHRRA 694
+ S +A
Sbjct: 1917 KASFEKA 1923
Score = 59.7 bits (143), Expect = 9e-09
Identities = 132/632 (20%), Positives = 240/632 (37%), Gaps = 106/632 (16%)
Query: 142 QGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQ 201
QG + ++ + K Q EL K ++ LR + + + +L+ ++
Sbjct: 1085 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1144
Query: 202 QHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQV 261
+ L H + V +E + +A L R ++ Q+ + Q+
Sbjct: 1145 VGERLQQRHGERDVEVERWRERVA-------------QLLERWQAVLAQTDVRQRELEQL 1191
Query: 262 AHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPI 321
+ Y + + +Q+ R + Q +A +L + QA E I
Sbjct: 1192 GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-------RQEQALLEEI 1244
Query: 322 QQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREA 381
++ E+ E E + +++ A+++ E++ V LE P+ + + + E Q E
Sbjct: 1245 ERHGEKVE-ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EY 1302
Query: 382 ANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQ-RLAVQQ-VEEAQQLREHQEALH---- 435
+L ++ E+ IKF S ++E++ RLA QQ EE ++L E + AL
Sbjct: 1303 VDLRTHYS--ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1360
Query: 436 -------------------QQRLQGHLLRQQE------QQQQQVAREM------------ 458
QQR+Q ++R++E QQ++ + E+
Sbjct: 1361 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1420
Query: 459 ALQRQAE-LEEGRPQHQEQLR--------QQAHYDAMDNDI------VQGAEDQGIQGEE 503
A RQAE E R + +E++R + + ++ + AE Q Q +E
Sbjct: 1421 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1480
Query: 504 GAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRA--AVEDI----NPADDPNNQ 557
A Q QDE++ E + EA+ E RA A+E++ A+ Q
Sbjct: 1481 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1540
Query: 558 GEDE--------FEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNV 609
E E E A++ E L + + + E + EEH+ +A ++ E
Sbjct: 1541 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1600
Query: 610 DEQYQ-----EEAEEEVQE-DLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDD 663
+Q + EEAE E++ L + L AEE + + EE E
Sbjct: 1601 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1660
Query: 664 NRPKGREEHYEEEEEEEEDGAAVAEKSHRRAE 695
R K E+ + E E++ EK + AE
Sbjct: 1661 RRGKAEEQAVRQRELAEQE----LEKQRQLAE 1688
Score = 54.7 bits (130), Expect = 3e-07
Identities = 79/346 (22%), Positives = 147/346 (42%), Gaps = 54/346 (15%)
Query: 42 KAEAV--ALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQET 99
K +AV A + + E L Q ++ E RL++ KE++ + A+E Q T
Sbjct: 2301 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQED--KEQMAQQLAEET-----QGFQRT 2353
Query: 100 LNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEE---HRKQ----GEDFSRTFND 152
L RQ R ++ + + LK + E+ + + EE+ RKQ GE RT
Sbjct: 2354 LEAERQ----RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2409
Query: 153 HKQKYLQLQ------QEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQ-QHKN 205
++K +Q Q+ + + +L+E + L E +L++ + + + ++++ Q +
Sbjct: 2410 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2469
Query: 206 LLSEHEQLVVTLEDHKSALAAAQTQVAEYKQ-----LKDTLNRIPSLRKPDPAEQQNVTQ 260
LL E + L + K +L + + + K +D + + LR+ +QQ + Q
Sbjct: 2470 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529
Query: 261 VAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPG-RAEDTKLYAPTHKEAEFQAPPE 319
R++ ++E R + HEA G R + +L E + + E
Sbjct: 2530 ----------ERQRLVASMEEARR-----RQHEAEEGVRRKQEELQ---QLEQQRRQQEE 2571
Query: 320 PIQQEVERREPEEHQVEEEHRKAL---EEEEMEQVGQAEHLEEEHD 362
+ +E +R + +EE+HR AL EE QV + L D
Sbjct: 2572 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2617
Score = 50.8 bits (120), Expect = 4e-06
Identities = 64/262 (24%), Positives = 118/262 (45%), Gaps = 41/262 (15%)
Query: 30 AMLYYELQTQLRKAEAVALKYQQ----HQESLSAQLQVVYEH-RSRLEKSLQKER-LEHK 83
A L E + ++A+ + LK ++ QE L + Q + + S + LQ+ER +E +
Sbjct: 2439 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2498
Query: 84 KAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQG 143
KAK + L A+ + R++ + + + Q L + EE +++ + EE R++
Sbjct: 2499 KAKLEQLFQDEVAKA--QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2556
Query: 144 EDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
E+ QL+Q++ Q+ L EEN++LR+ QLQ +++QH
Sbjct: 2557 EELQ-----------QLEQQRRQQEEL-------LAEENQRLRE-------QLQLLEEQH 2591
Query: 204 KNLLSEHEQLVV-------TLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQ 256
+ L+ E++ TL + + AL + AE + D L R S ++ A
Sbjct: 2592 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAE-AEPEHSFDGLRRKVSAQRLQEAGIL 2650
Query: 257 NVTQVAHSPQGYNTAREKPTRE 278
+ ++ QG+ T E RE
Sbjct: 2651 SAEELQRLAQGHTTVDELARRE 2672
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 95.5 bits (236), Expect = 1e-19
Identities = 159/750 (21%), Positives = 313/750 (41%), Gaps = 111/750 (14%)
Query: 39 QLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERL-EHKKAKEDFLVYKL--- 94
Q R+ E A +++ E AQL+ + +K L ++ L + ++ +E+ L K
Sbjct: 1903 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1962
Query: 95 -----EAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRT 149
+A+ L GR SN+ + + + L++ + +Q + EE R++ E+ +
Sbjct: 1963 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ---RQLAAEEERRRREAEERVQK 2019
Query: 150 FNDHKQKYLQLQQEKEQELSKLKETVYNLR--------EENRQLRKAHQDIHTQLQDVKQ 201
+++ + ++ +E+ +LK V R E RQL+ A + +LQ ++
Sbjct: 2020 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2079
Query: 202 QHKNLLSEHEQ-LVVTLEDHKSAL---------AAAQTQVAEYKQLKDTLNRIPSLRKPD 251
H + + EQ L TL+ +S L A + AE +++ S R+ +
Sbjct: 2080 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2139
Query: 252 PAEQ--QNVTQVAHSPQGYNTAREKPTREV-QEVSRNNDVWQ----NHEAVPGRAEDTKL 304
AE+ Q+ + A + A EK +E QE +R Q +A E K
Sbjct: 2140 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2199
Query: 305 YAPT--HKEAEFQAPPEPIQQEVERREPEEHQVEEE-------------HRKALEEE--- 346
+A ++A+ + ++ ++E + +++ ++EE R +EEE
Sbjct: 2200 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2259
Query: 347 ---EMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLE-GHARAEVYPSAKPMIK 402
+ME++ + + E + + +D++ ++ Q EA + + A + +A+ +
Sbjct: 2260 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2319
Query: 403 FQSPYEEQLEQQRLA--------VQQVEEAQQLREHQEALHQQR-LQGHLLRQQEQQQQQ 453
+ EE L QQR +Q V+EA +L+ E L QQ+ L R+ ++ ++Q
Sbjct: 2320 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2379
Query: 454 VAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQ 513
+A+++A + Q + Q QL A + + + + + Q E+ R Q
Sbjct: 2380 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK---Q 2436
Query: 514 DEAEGDPGNRHEPREQGP-----------READPESEADRAAVEDINPADDPNNQGED-- 560
E G+ +R E Q +++D ++E R A+ ++ + Q
Sbjct: 2437 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2496
Query: 561 --EFEEAEQVREENLPDENEEQKQS--NQK-----------QENTEVEEHLVMAGNPDQQ 605
+ EE + V++E L E + +QS ++K QE ++E+ QQ
Sbjct: 2497 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2556
Query: 606 EDNVDEQYQEEAEEEVQEDLTE-EKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDN 664
++ Q++ E+E Q + E+ R +H AEE E E Q++
Sbjct: 2557 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---------ELQQLEQQR 2607
Query: 665 RPKGREEHYEEEEEEEEDGAAVAEKSHRRA 694
R +EE EE + + + E+ HR A
Sbjct: 2608 RQ--QEELLAEENQRLREQLQLLEEQHRAA 2635
Score = 86.3 bits (212), Expect = 9e-17
Identities = 117/482 (24%), Positives = 214/482 (44%), Gaps = 65/482 (13%)
Query: 35 ELQTQLR-KAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYK 93
E Q Q R +A+A A K ++ E +A+ + R +++ E +HKK E L K
Sbjct: 2149 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2208
Query: 94 LEAQETLNKGR---QDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEH---RKQGEDFS 147
+ ++ L R ++++ + + L+ + Q LK++ E +Q S +EEE R Q E+ S
Sbjct: 2209 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2268
Query: 148 RTF--------------NDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIH 193
+ D+ Q++LQ + EK +++++ + +E +LR+ ++
Sbjct: 2269 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2326
Query: 194 TQLQDVKQQH---KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKP 250
D+ QQ + +L E Q V + L A + + K+L R+
Sbjct: 2327 ----DLAQQRALAEKMLKEKMQAV----QEATRLKAEAELLQQQKELAQE-----QARRL 2373
Query: 251 DPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHK 310
++Q Q+A QG+ E + E+S + + A RA+ A +
Sbjct: 2374 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ-----ARAEE 2428
Query: 311 EAE-FQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEE---EHDPSPE 366
+A+ F+ E I +++ R E Q + + LE + + AE L E E + E
Sbjct: 2429 DAQRFRKQAEEIGEKLHRTELAT-QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2487
Query: 367 EQDREWK-------EQHEQREAANLLEGHARAEVYPSAKPMIKFQSPY--EEQLEQQRLA 417
+ +E K E ++ L E A + + S K + + + +E+ + ++L
Sbjct: 2488 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2547
Query: 418 VQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQL 477
+V +AQQLRE Q+ QQ +QE+Q+ + E A +RQ E EEG + QE+L
Sbjct: 2548 QDEVAKAQQLREEQQRQQQQM-------EQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2600
Query: 478 RQ 479
+Q
Sbjct: 2601 QQ 2602
Score = 80.5 bits (197), Expect = 5e-15
Identities = 154/754 (20%), Positives = 291/754 (38%), Gaps = 110/754 (14%)
Query: 35 ELQTQLRKAEAVA---LKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLV 91
E+Q + R+AEA L+ ++ + QL+ R E LQ R ++A+
Sbjct: 1459 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1518
Query: 92 YKLEAQETLNKGRQDSNSRYSALNVQ-HQMLKSQHEELKKQHSDLE--EEHRKQGEDFSR 148
+ EA E L + QD + R V+ +K++ E +++ L+ EE R Q E+ R
Sbjct: 1519 AQEEA-ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1577
Query: 149 TFNDH-----KQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
+Q + L+ + ++L+ + E+ QL ++ Q+ H + ++++
Sbjct: 1578 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1637
Query: 204 KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH 263
+ + + E+ + L Q + E +L+ L+ + A+Q+++ Q
Sbjct: 1638 ERRAQQQAEAERAREEAERELERWQLKANEALRLR--------LQAEEVAQQKSLAQAEA 1689
Query: 264 SPQGYNTARE----------------------KPTREVQEVSRNNDVWQNHEAVPGRAE- 300
Q RE + R++ E + + E + RAE
Sbjct: 1690 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1749
Query: 301 -----------------DTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKAL 343
+ A T K E +A ++ E+E + + EEE R
Sbjct: 1750 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1809
Query: 344 EEEEME---QVGQAEHLEEEHD-----PSPEEQDREWKEQHEQREAANLLEGHARAEVYP 395
E+ + + G+ L EE ++ R+ E+ R+ A A
Sbjct: 1810 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1869
Query: 396 SAKPMIKFQSPY---EEQLEQQRLAVQQVEEAQQLR--EHQEALHQQRLQGHLLRQQEQQ 450
+K ++ E++ E +RL +EA Q R E Q A H+ ++ L + ++
Sbjct: 1870 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1929
Query: 451 QQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMD----------NDIVQGAEDQGIQ 500
++ R+ L L + R +E L +A ++ I AED
Sbjct: 1930 DSELERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1988
Query: 501 GEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADR---AAVEDINPADDPNNQ 557
E+ E Q Q AE + R E E+ + E EA R AA+E++
Sbjct: 1989 KEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAARQRKAALEEVERL------ 2041
Query: 558 GEDEFEEAEQVREENLPDENEE---QKQSNQKQENTEVEEHLVMAGNPD-------QQED 607
+ + EEA ++RE + + +++ QK+ E + H + QQE
Sbjct: 2042 -KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2100
Query: 608 NVDEQYQEEAEEEVQ-EDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRP 666
+V +Q + EAE + + EE + + E A ++ + +E K + E+ + R +
Sbjct: 2101 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2160
Query: 667 KGREEHYEEEEE----EEEDGAAVAEKSHRRAEM 696
+ E E+E + + AA+ +K AEM
Sbjct: 2161 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2194
Score = 76.3 bits (186), Expect = 9e-14
Identities = 139/679 (20%), Positives = 259/679 (38%), Gaps = 61/679 (8%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRL---------EKSLQKERLEHKKA 85
E + Q + AE A + + E + A+ +RL EK + ERL
Sbjct: 1839 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1898
Query: 86 KEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEE--EHRKQG 143
E F +LE Q +K D R + Q+ K+ EL++Q +E+ R+Q
Sbjct: 1899 DEAFQRRRLEEQAAQHKA--DIEERLA------QLRKASDSELERQKGLVEDTLRQRRQV 1950
Query: 144 EDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
E+ +K + E E EL +++ N + R +A + Q Q ++
Sbjct: 1951 EEEILALKASFEKAAAGKAELELELGRIRS---NAEDTLRSKEQAELEAARQRQLAAEEE 2007
Query: 204 KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH 263
+ E++ +L + A + + E ++LK + LR+ E Q+A
Sbjct: 2008 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2067
Query: 264 SPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQ 323
E+ + ++ Q + + + A + A +A +Q
Sbjct: 2068 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2127
Query: 324 EVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAAN 383
E E + E E K EE+ + QA+ E+ +E ++E + + +AA
Sbjct: 2128 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK---LRKEAEQEAARRAQAEQAAL 2184
Query: 384 LLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLR-EHQEALHQQRLQGH 442
+ A AE+ K + EQ +Q+ V+Q E LR + +E HQ+ L
Sbjct: 2185 RQKQAADAEMEKHKK--------FAEQTLRQKAQVEQ--ELTTLRLQLEETDHQKNLLDE 2234
Query: 443 LLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGE 502
L++ + + + AR+ + Q + EL R Q +E + +A +A + ++ +D +
Sbjct: 2235 ELQRLKAEATEAARQRS-QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2293
Query: 503 EGAYERDNQHQDE-----------------AEGDPGNRHEPREQGPRE-ADPESEADRAA 544
+ E+ Q +E AE D + E+ +E EA R
Sbjct: 2294 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2353
Query: 545 VEDINPADDPNNQGEDEFEEAEQVRE--ENLPDENEEQKQSNQKQENTEVEEHLVMAGNP 602
E A+ Q E E+A +++E E + + E+ Q Q+ E + L M+
Sbjct: 2354 AE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2409
Query: 603 DQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRD 662
++ + V E + +A E ++ E+ T E +++ D
Sbjct: 2410 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2469
Query: 663 DNRPKGREEHYEEEEEEEE 681
+ + RE E E E+E+
Sbjct: 2470 HDAERLREAIAELEREKEK 2488
Score = 71.6 bits (174), Expect = 2e-12
Identities = 97/435 (22%), Positives = 185/435 (42%), Gaps = 38/435 (8%)
Query: 31 MLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKER----LEHKKAK 86
+L ELQ +A A + Q +E L + ++V E S+L+ ++ E L K
Sbjct: 2231 LLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKLKARIEAENRALILRDKDNT 2289
Query: 87 EDFLVYKLEAQETLNKGRQ--DSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGE 144
+ FL QE K +Q + +R S + L+ EE Q L E+ K+
Sbjct: 2290 QRFL------QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2343
Query: 145 DFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHK 204
+ K + LQQ+KE + + + + +QL + Q L+ +Q+
Sbjct: 2344 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2403
Query: 205 NLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH- 263
+ +E E+L + + + A A A+ +++ + + L + + A Q+ VT V
Sbjct: 2404 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE--KLHRTELATQEKVTLVQTL 2461
Query: 264 --SPQGYNTAREKPTREVQEVSRNND-VWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEP 320
Q + E+ + E+ R + + Q + + ++E+ + E QA +
Sbjct: 2462 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2521
Query: 321 IQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQRE 380
E + E +E+E K LE+ ++V +A+ L EE +++ ++ EQ QR
Sbjct: 2522 FLSEKDSLLQRERFIEQEKAK-LEQLFQDEVAKAQQLREE-----QQRQQQQMEQERQRL 2575
Query: 381 AANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQ 440
A++ E R Q EE + +++ +QQ+E+ ++ +E A QRL+
Sbjct: 2576 VASMEEARRR-------------QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2622
Query: 441 GHLLRQQEQQQQQVA 455
L +EQ + +A
Sbjct: 2623 EQLQLLEEQHRAALA 2637
Score = 64.3 bits (155), Expect = 4e-10
Identities = 154/727 (21%), Positives = 293/727 (40%), Gaps = 103/727 (14%)
Query: 43 AEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDF----LVYKLEAQE 98
A++ A++ Q QE A L+ + H ++E+ Q+ ++ A +D+ + YK + +
Sbjct: 1266 ADSQAVREQLRQEQ--ALLEEIERHGEKVEEC-QRFAKQYINAIKDYELQLVTYKAQLEP 1322
Query: 99 TLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYL 158
+ ++ S +Q ++ +L+ +S+L + + S T +++
Sbjct: 1323 VASPAKKPKVQSGSESVIQ------EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1376
Query: 159 QLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQ--------------------- 197
+Q++ +E +L E L E+ RQL +AH Q +
Sbjct: 1377 LAEQQRAEERERLAEVEAAL-EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1435
Query: 198 -DVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLK-DTLNRIPSL------RK 249
D +QQ +++ E +QL + E A A Q + AE +L+ + R+ L R+
Sbjct: 1436 VDAQQQKRSIQEELQQLRQSSEAEIQA-KARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1494
Query: 250 PDPAEQQNVTQVAHSPQGYNTAR------EKPTREVQEVSRNNDVWQ-------NHEAVP 296
AE + A + + R E+ R+VQ+ S+ + EA
Sbjct: 1495 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1554
Query: 297 GRAEDTKLYAPTHKEAEFQAPPEPIQQ-EVERREPEEHQVEEEHRKALEEEEMEQVGQAE 355
R + L A + + ++Q EVER + +E R A E + ++ AE
Sbjct: 1555 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1614
Query: 356 H-------LEEEHDPSPEEQDREWKEQHEQREAANLLEGHARA--EVYPSAKPMIKFQSP 406
L+EEH + ++ + +Q EA E R A ++ +
Sbjct: 1615 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1674
Query: 407 YEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAEL 466
EE +Q+ LA + E+ ++ E +EA + + + +RQ+E +Q+ L++Q +L
Sbjct: 1675 AEEVAQQKSLAQAEAEKQKEEAE-REARRRGKAEEQAVRQRELAEQE------LEKQRQL 1727
Query: 467 EEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGA-YERD----NQHQDEAEGDPG 521
EG Q++L + + + QG + + + EE A +R+ Q + E E +
Sbjct: 1728 AEGTA--QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1785
Query: 522 N-RHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQ 580
R E +A E E+ + + + + + EEA ++R L +E + Q
Sbjct: 1786 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA--LAEEAKRQ 1843
Query: 581 KQ------SNQKQENTEV-EEHLVMAGNPDQQEDNVDEQYQE-EAEEEVQEDLTEE---K 629
+Q + Q+ E V E L G + + + +E EAE E L E+ +
Sbjct: 1844 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1903
Query: 630 KRELEHNAEETYGENDENTDD--KNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVA 687
+R LE A + + +E K +D E + R KG E + + E+
Sbjct: 1904 RRRLEEQAAQHKADIEERLAQLRKASDSELE------RQKGLVEDTLRQRRQVEEEILAL 1957
Query: 688 EKSHRRA 694
+ S +A
Sbjct: 1958 KASFEKA 1964
Score = 59.7 bits (143), Expect = 9e-09
Identities = 132/632 (20%), Positives = 240/632 (37%), Gaps = 106/632 (16%)
Query: 142 QGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQ 201
QG + ++ + K Q EL K ++ LR + + + +L+ ++
Sbjct: 1126 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1185
Query: 202 QHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQV 261
+ L H + V +E + +A L R ++ Q+ + Q+
Sbjct: 1186 VGERLQQRHGERDVEVERWRERVA-------------QLLERWQAVLAQTDVRQRELEQL 1232
Query: 262 AHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPI 321
+ Y + + +Q+ R + Q +A +L + QA E I
Sbjct: 1233 GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-------RQEQALLEEI 1285
Query: 322 QQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREA 381
++ E+ E E + +++ A+++ E++ V LE P+ + + + E Q E
Sbjct: 1286 ERHGEKVE-ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EY 1343
Query: 382 ANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQ-RLAVQQ-VEEAQQLREHQEALH---- 435
+L ++ E+ IKF S ++E++ RLA QQ EE ++L E + AL
Sbjct: 1344 VDLRTHYS--ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1401
Query: 436 -------------------QQRLQGHLLRQQE------QQQQQVAREM------------ 458
QQR+Q ++R++E QQ++ + E+
Sbjct: 1402 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1461
Query: 459 ALQRQAE-LEEGRPQHQEQLR--------QQAHYDAMDNDI------VQGAEDQGIQGEE 503
A RQAE E R + +E++R + + ++ + AE Q Q +E
Sbjct: 1462 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1521
Query: 504 GAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRA--AVEDI----NPADDPNNQ 557
A Q QDE++ E + EA+ E RA A+E++ A+ Q
Sbjct: 1522 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1581
Query: 558 GEDE--------FEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNV 609
E E E A++ E L + + + E + EEH+ +A ++ E
Sbjct: 1582 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1641
Query: 610 DEQYQ-----EEAEEEVQE-DLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDD 663
+Q + EEAE E++ L + L AEE + + EE E
Sbjct: 1642 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1701
Query: 664 NRPKGREEHYEEEEEEEEDGAAVAEKSHRRAE 695
R K E+ + E E++ EK + AE
Sbjct: 1702 RRGKAEEQAVRQRELAEQE----LEKQRQLAE 1729
Score = 54.7 bits (130), Expect = 3e-07
Identities = 79/346 (22%), Positives = 147/346 (42%), Gaps = 54/346 (15%)
Query: 42 KAEAV--ALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQET 99
K +AV A + + E L Q ++ E RL++ KE++ + A+E Q T
Sbjct: 2342 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQED--KEQMAQQLAEET-----QGFQRT 2394
Query: 100 LNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEE---HRKQ----GEDFSRTFND 152
L RQ R ++ + + LK + E+ + + EE+ RKQ GE RT
Sbjct: 2395 LEAERQ----RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2450
Query: 153 HKQKYLQLQ------QEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQ-QHKN 205
++K +Q Q+ + + +L+E + L E +L++ + + + ++++ Q +
Sbjct: 2451 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2510
Query: 206 LLSEHEQLVVTLEDHKSALAAAQTQVAEYKQ-----LKDTLNRIPSLRKPDPAEQQNVTQ 260
LL E + L + K +L + + + K +D + + LR+ +QQ + Q
Sbjct: 2511 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570
Query: 261 VAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPG-RAEDTKLYAPTHKEAEFQAPPE 319
R++ ++E R + HEA G R + +L E + + E
Sbjct: 2571 ----------ERQRLVASMEEARR-----RQHEAEEGVRRKQEELQ---QLEQQRRQQEE 2612
Query: 320 PIQQEVERREPEEHQVEEEHRKAL---EEEEMEQVGQAEHLEEEHD 362
+ +E +R + +EE+HR AL EE QV + L D
Sbjct: 2613 LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2658
Score = 50.8 bits (120), Expect = 4e-06
Identities = 64/262 (24%), Positives = 118/262 (45%), Gaps = 41/262 (15%)
Query: 30 AMLYYELQTQLRKAEAVALKYQQ----HQESLSAQLQVVYEH-RSRLEKSLQKER-LEHK 83
A L E + ++A+ + LK ++ QE L + Q + + S + LQ+ER +E +
Sbjct: 2480 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2539
Query: 84 KAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQG 143
KAK + L A+ + R++ + + + Q L + EE +++ + EE R++
Sbjct: 2540 KAKLEQLFQDEVAKA--QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2597
Query: 144 EDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
E+ QL+Q++ Q+ L EEN++LR+ QLQ +++QH
Sbjct: 2598 EELQ-----------QLEQQRRQQEEL-------LAEENQRLRE-------QLQLLEEQH 2632
Query: 204 KNLLSEHEQLVV-------TLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQ 256
+ L+ E++ TL + + AL + AE + D L R S ++ A
Sbjct: 2633 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAE-AEPEHSFDGLRRKVSAQRLQEAGIL 2691
Query: 257 NVTQVAHSPQGYNTAREKPTRE 278
+ ++ QG+ T E RE
Sbjct: 2692 SAEELQRLAQGHTTVDELARRE 2713
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 94.7 bits (234), Expect = 2e-19
Identities = 84/387 (21%), Positives = 159/387 (41%), Gaps = 14/387 (3%)
Query: 309 HKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAE-HLEEEHDPSPEE 367
HK+A+ Q+E ERR + E RK E ++ + + H E + D E
Sbjct: 46 HKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKER 105
Query: 368 QDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQL 427
+ + +E+ QRE + E + Q+ + + E+QR A ++ E Q
Sbjct: 106 ERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKE-RERQTD 164
Query: 428 REHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMD 487
RE Q + R + ++ ++ +Q RE QR+ E + +H E+ R++ +
Sbjct: 165 RERQRQTERNRQK----EREREKNRQERRERERQREKE-NKTEDRHSERGRERERERETE 219
Query: 488 NDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVED 547
+ + + + + ER+ + Q E E E ++ RE D + + DR E
Sbjct: 220 TETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKER 279
Query: 548 INPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQED 607
D + + E E+ RE E E +++ N+K+E E Q+E
Sbjct: 280 ERQTDRKRQRRTERDRETERKRERQ--RERERERERNRKRERERERER----ERERQRET 333
Query: 608 NVDEQYQEEAEEEVQEDLTEEKKREL-EHNAEETYGENDENTDDKNNDGEEQEVRDDNRP 666
D + + E + + Q ++ E+ R+ + E + + E+E R+ +R
Sbjct: 334 ERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRD 393
Query: 667 KGREEHYEEEEEEEEDGAAVAEKSHRR 693
+ R++ E + E++ DG EK R
Sbjct: 394 RDRQKERERQTEKDRDGQRETEKQRER 420
Score = 85.5 bits (210), Expect = 2e-16
Identities = 83/410 (20%), Positives = 169/410 (41%), Gaps = 27/410 (6%)
Query: 280 QEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEF-QAPPEPIQQEVERREPEEHQVEEE 338
QE R + Q H+ G + + E Q E ++ RRE + H+ +
Sbjct: 34 QESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDR 93
Query: 339 HRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAK 398
HR+ + E E+ Q + E D E++ KE+ + E EG + +
Sbjct: 94 HRERQRDREKERERQTDR---ERDRQREKERNRQKERERETER----EGERGRDRQTDGQ 146
Query: 399 PMIKFQSPYEEQLEQQ--RLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQ---- 452
+ Q E++ E+Q R +Q E +Q +E Q+R + R++E + +
Sbjct: 147 RERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHS 206
Query: 453 QVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQH 512
+ RE +R+ E E R + ++ R + + + + AE E A ER+ +
Sbjct: 207 ERGRERERERETETETERKRQTDRERDRQRKTERERE--KQAE------RERASERETER 258
Query: 513 QDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREEN 572
E E + R R++ R+ + E + DR + D + + E E+ RE N
Sbjct: 259 DKERERE---RDRDRDRDRRQKERERQTDRKR-QRRTERDRETERKRERQRERERERERN 314
Query: 573 LPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRE 632
E E +++ ++++ + +++ +D + + E + E++RE
Sbjct: 315 RKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERE 374
Query: 633 LEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEED 682
E + ++ E +E D++ D +++ R + + + E++ E E+D
Sbjct: 375 RERD-RQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKD 423
Score = 74.7 bits (182), Expect = 3e-13
Identities = 96/458 (20%), Positives = 184/458 (40%), Gaps = 58/458 (12%)
Query: 100 LNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQ 159
L + +D++ N Q + + + + ++ +D + E R++ +D R + H+++
Sbjct: 42 LGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRRE-KDRHRKRDRHRERQRD 100
Query: 160 LQQEKEQELSKLKETVYNLREENRQLRKAHQ---------DIHTQLQDVKQQHKNLLSEH 210
++E+E++ + ++ +E NRQ + + D T Q +++ ++ E
Sbjct: 101 REKERERQTDRERDRQRE-KERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKER 159
Query: 211 EQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNT 270
E+ QT+ K+ + NR + E++N T+ HS +G
Sbjct: 160 ER-------QTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRER 212
Query: 271 AREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPE-PIQQEVER-R 328
RE+ T E R D R D + T +E E QA E ++E ER +
Sbjct: 213 ERERETETETERKRQTD----------RERDRQ--RKTEREREKQAERERASERETERDK 260
Query: 329 EPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGH 388
E E + + R ++E Q + E D E + +E+ +RE E
Sbjct: 261 ERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERE 320
Query: 389 ARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQ--GHLLRQ 446
E E+ Q+ + +E ++ R+ Q + ++R + G R+
Sbjct: 321 RERE---------------RERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRR 365
Query: 447 QEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAY 506
Q +++++ RE Q E EE R + +++ RQ+ + D G + E
Sbjct: 366 QAERERERERERDRQSAREREE-RERDRDRDRQKERERQTEKD------RDGQRETEKQR 418
Query: 507 ERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAA 544
ER+ + E + G E +Q RE D E + DR A
Sbjct: 419 EREKDRESERGRERGRERE--KQKGRERDRERQTDRQA 454
Score = 67.4 bits (163), Expect = 4e-11
Identities = 80/408 (19%), Positives = 155/408 (37%), Gaps = 54/408 (13%)
Query: 272 REKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPE 331
RE+ +E R D ++ + R + T +E E Q + +R
Sbjct: 95 RERQRDREKERERQTDRERDRQREKERNRQKERERETEREGE---RGRDRQTDGQRERER 151
Query: 332 EHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQ-----DREWKEQHEQREAANLLE 386
+ E+E + + E Q + E E + + +E+ RE + + E R + E
Sbjct: 152 QRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRE 211
Query: 387 GHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQ 446
E E + E++R + + R+ Q ++R
Sbjct: 212 RERERET--------------ETETERKR-------QTDRERDRQRKTERER-------- 242
Query: 447 QEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAY 506
++Q +++ A E +R E E R + +++ R+Q + + Q ++ + E
Sbjct: 243 EKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETER--- 299
Query: 507 ERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAE 566
+R+ Q + E E + + E + RE + + E +R D + + E
Sbjct: 300 KRERQRERERERERNRKRERERERERERERQRETER---------DREKERERKRKRQTE 350
Query: 567 QVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQED-- 624
RE N E ++Q+ +++E E E A +++E + D Q+E E + ++D
Sbjct: 351 MDRERNRQTGREGRRQAERERER-ERERDRQSAREREERERDRDRDRQKERERQTEKDRD 409
Query: 625 --LTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGRE 670
EK+RE E + E G +K E R +R GR+
Sbjct: 410 GQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQ 457
Score = 55.8 bits (133), Expect = 1e-07
Identities = 40/192 (20%), Positives = 84/192 (43%), Gaps = 10/192 (5%)
Query: 511 QHQDEAEGDPGNRHEPREQGPR------EADPESEADRAAVEDINPADDPNNQGEDEFEE 564
Q +A+GD R+ +E+ R E + + + +R +D + D + + + + E
Sbjct: 44 QAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRD-RE 102
Query: 565 AEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQED 624
E+ R+ + + + +K+ N+++E E G Q + + + Q +AE+E +
Sbjct: 103 KERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQ 162
Query: 625 LTEEKKRELEHNAE---ETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEE 681
E++R+ E N + E E + + +E + D + +GRE E E E E
Sbjct: 163 TDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETET 222
Query: 682 DGAAVAEKSHRR 693
+ ++ R
Sbjct: 223 ERKRQTDRERDR 234
Score = 36.6 bits (83), Expect = 0.081
Identities = 35/177 (19%), Positives = 66/177 (37%), Gaps = 49/177 (27%)
Query: 520 PGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEE 579
PG++ PR +G +A +++ D RE N E E
Sbjct: 31 PGSQESPRRRGLGQAHKDADGDD--------------------------RERNRQKERER 64
Query: 580 QKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEE 639
+++ Q + T+ + ++ D + + E Q D +E++R+ +
Sbjct: 65 RREKRQTERETDRKR---------ERRREKDRHRKRDRHRERQRDREKERERQTDR---- 111
Query: 640 TYGENDENTDDKNNDGEEQE---VRDDNRPKGREEHYEEEEEEEEDGAAVAEKSHRR 693
E D + + N +E+E R+ R + R+ + E E + D AEK R
Sbjct: 112 ---ERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRD----AEKERER 161
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 92.8 bits (229), Expect = 9e-19
Identities = 107/573 (18%), Positives = 255/573 (44%), Gaps = 56/573 (9%)
Query: 118 HQML--KSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETV 175
H M+ +++ +L + L + H + +D K+K + E S
Sbjct: 36 HPMMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSG---GC 92
Query: 176 YNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYK 235
++ +E + + + + +L+ Q + L + +L + L + A+ + +
Sbjct: 93 HSPEDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEA---- 148
Query: 236 QLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQ----- 290
+D ++R+ K +Q ++ VA T ++K R ++E+++ D
Sbjct: 149 --RDLISRLHDSWKFAGELEQALSAVA-------TQKKKADRYIEELTKERDALSLELYR 199
Query: 291 ----NHEAVPGRAE-DTKLYAPTHKEAEFQAPPEPIQQEVERRE----PEEHQVEEEHR- 340
+ E A+ KL +++E Q + +++++ER + ++ Q E +H
Sbjct: 200 NTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 259
Query: 341 KALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPM 400
K L+ + Q E E + + +++++ W+++ + +E ++ K
Sbjct: 260 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMR 319
Query: 401 IKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMAL 460
+ + +E++ + +R E+ +++RE +E +H+Q +R+QE+++Q+ +
Sbjct: 320 RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ----EKIREQEEKRQEEEKIREQ 375
Query: 461 QRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDP 520
+++ E E + +E++R+Q +++Q E++ + EE +E++ + Q++ E
Sbjct: 376 EKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMR 435
Query: 521 GNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAE-QVREENLPDENEE 579
+ REQ + + E E I ++ + E++ E E ++ E+ + +E
Sbjct: 436 RQEEKIREQEKKIREQE--------EKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQE 487
Query: 580 QKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEE 639
+K Q+++ E E+ + +QE+ + E QEE +E +E + E++++ E EE
Sbjct: 488 EKMRRQEEKIREQEKKI------REQEEKIRE--QEEMMQEQEEKMWEQEEKMCEQ--EE 537
Query: 640 TYGENDENTDDKNNDGEEQEVRDDNRPKGREEH 672
E +E + EQEVR + + +EH
Sbjct: 538 KMQEQEEKMRRQEEKMREQEVRLRQQEEKMQEH 570
Score = 78.6 bits (192), Expect = 2e-14
Identities = 109/505 (21%), Positives = 214/505 (42%), Gaps = 59/505 (11%)
Query: 52 QHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRY 111
QHQE+L +L+ + L + QK L+ V +LE + R + ++
Sbjct: 104 QHQEALRRELEAQVQTIRIL--TCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKF 161
Query: 112 --------SALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQE 163
SA+ Q + EEL K+ L E + + T + K+K +LQ++
Sbjct: 162 AGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN----TITDEELKEKNAKLQEK 217
Query: 164 KEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSA 223
+ S+ E N++E R+L +A + Q + H ++ +S
Sbjct: 218 LQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG------------KELQSV 265
Query: 224 LAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVS 283
A Q QV E + NR+ ++ Q+ Q +E+ RE +E
Sbjct: 266 SAKLQAQVEE----NELWNRLNQQQEEKMWRQEEKIQEREEKI---QEQEEKIREQEEKM 318
Query: 284 RNND--VWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRK 341
R + +W+ E + R ++ ++ KE + + E + ++ + RE EE + EEE
Sbjct: 319 RRQEEMMWEKEEKM--RRQEEMMW---EKEEKIRELEEKMHEQEKIREQEEKRQEEEK-- 371
Query: 342 ALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMI 401
+ E+E Q +A+ +E EQ+ + +EQ E + G +++ + M
Sbjct: 372 -IREQEKRQEQEAKMWRQEE--KIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEM- 427
Query: 402 KFQSPYEEQLEQQRLAVQQV-EEAQQLREHQEALHQQR--LQGHLLRQQEQQQQQVAREM 458
+EQ E+ R +++ E+ +++RE +E + +Q +Q + EQ+ + +E
Sbjct: 428 ------QEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEA 481
Query: 459 ALQRQAE----LEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQD 514
+Q Q E EE + ++++R+Q +++Q E++ + EE E++ + Q+
Sbjct: 482 KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 541
Query: 515 EAEGDPGNRHEPREQGPREADPESE 539
+ E + REQ R E +
Sbjct: 542 QEEKMRRQEEKMREQEVRLRQQEEK 566
Score = 67.4 bits (163), Expect = 4e-11
Identities = 81/366 (22%), Positives = 155/366 (42%), Gaps = 20/366 (5%)
Query: 337 EEHRKALEEEEMEQVGQAEHLEEEHDPSPEE------QDREWKEQHEQREAANLLEGHAR 390
E+ A+ ++ + E L +E D E D E KE++ + + L +
Sbjct: 166 EQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEK 225
Query: 391 AEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQ 450
+E+ + K + + + L QQ+L + ++L+ L Q + L + QQ
Sbjct: 226 SEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQ 285
Query: 451 QQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDN 510
Q++ + Q E EE + +E++R+Q +++ E++ + EE +E++
Sbjct: 286 QEEKMWRQEEKIQ-EREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 344
Query: 511 QHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVRE 570
+ + E E + + REQ E E E R + Q E E+ E++RE
Sbjct: 345 KIR-ELEEKMHEQEKIREQ--EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 401
Query: 571 ENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKK 630
+ + +E+K Q+++ E EE + +QE+ + Q ++ E+E + EEK
Sbjct: 402 QEEMMQEQEEKMGEQEEKMWEQEEEM------QEQEEKMRRQEEKIREQEKKIREQEEKI 455
Query: 631 RELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVAEKS 690
RE EE E +E ++ EQE + + + E+ E+E+ EK
Sbjct: 456 RE----QEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKI 511
Query: 691 HRRAEM 696
+ EM
Sbjct: 512 REQEEM 517
Score = 64.7 bits (156), Expect = 3e-10
Identities = 110/555 (19%), Positives = 231/555 (41%), Gaps = 68/555 (12%)
Query: 164 KEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVV----TLED 219
KE SKL E L + + Q + + T D K++ N + E + ED
Sbjct: 41 KETRQSKLAEAKEQLTDHHPQ---TNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPED 97
Query: 220 HKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREV 279
+ A + Q Q A ++L+ + I L ++ + + Q E R++
Sbjct: 98 EQKA--SHQHQEALRRELEAQVQTIRILT----CQKTELQMALYYSQHAVKQLEGEARDL 151
Query: 280 QEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEA------EFQAPPEPIQQEVERREPEEH 333
+SR +D W+ G E T K+ E + + E+ R +
Sbjct: 152 --ISRLHDSWK----FAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDE 205
Query: 334 QVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLL--EGHARA 391
+++E++ K E+ ++ +E E E KE + E A LL + +A
Sbjct: 206 ELKEKNAKLQEKLQL--------VESEKS----EIQLNVKELKRKLERAKLLLPQQQLQA 253
Query: 392 EVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQ 451
E K + + + Q+E+ L + ++ ++ QE Q+R ++ Q+Q
Sbjct: 254 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQER------EEKIQEQ 307
Query: 452 QQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQ 511
++ RE ++ EE + +E++R+Q + ++ E++ + +E E++ +
Sbjct: 308 EEKIREQE-EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK-MHEQEKIREQEEK 365
Query: 512 HQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREE 571
Q+E + E R++ + + E R E I ++ + E++ E E+ E
Sbjct: 366 RQEE---EKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWE 422
Query: 572 NLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKR 631
+ E++++ +++E +E + +QE+ + E QEE +E +E + E++ +
Sbjct: 423 QEEEMQEQEEKMRRQEEKIREQEKKIR-----EQEEKIRE--QEEMMQEQEEKMGEQEGK 475
Query: 632 ELEHNAEETYGENDENTDDKNNDGEEQEVRD-DNRPKGREEHYEEEEE----------EE 680
E A+ E ++ +E+++R+ + + + +EE +E+EE E+
Sbjct: 476 MCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 535
Query: 681 EDGAAVAEKSHRRAE 695
E+ E+ RR E
Sbjct: 536 EEKMQEQEEKMRRQE 550
Score = 63.2 bits (152), Expect = 8e-10
Identities = 97/446 (21%), Positives = 181/446 (40%), Gaps = 62/446 (13%)
Query: 290 QNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEME 349
Q + +V A DTK K+ PE +E + +H++AL E
Sbjct: 61 QTNPSVGTAASDTK-----KKKINNGTNPETTTSGGCHSPEDEQKASHQHQEALRRELEA 115
Query: 350 QVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEE 409
QV L + E Q + QH A LEG AR ++ KF E+
Sbjct: 116 QVQTIRILTCQ---KTELQMALYYSQH----AVKQLEGEAR-DLISRLHDSWKFAGELEQ 167
Query: 410 QLE----QQRLAVQQVEEAQQLRE------HQEALHQQRLQGHLLRQQEQQQQQVAREMA 459
L Q++ A + +EE + R+ ++ + + L+ + QE+ Q + +
Sbjct: 168 ALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSE 227
Query: 460 LQRQAE-----LEEGR---PQHQEQ----------------LRQQAHYDAMDNDIVQGAE 495
+Q + LE + PQ Q Q L+ Q + + N + Q E
Sbjct: 228 IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQE 287
Query: 496 DQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPN 555
++ + EE ER+ + Q++ E + R Q + E E R E + ++
Sbjct: 288 EKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKE-EKMRRQEEMMWEKEEKI 346
Query: 556 NQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQY-- 613
+ E++ E E++RE+ + EE+ + +K++ E + +QE+ + EQ
Sbjct: 347 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW--------RQEEKIREQEEK 398
Query: 614 ---QEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGRE 670
QEE +E +E + E++++ E E E ++ +E+++R+ K RE
Sbjct: 399 IREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEE-KIRE 457
Query: 671 EHYEEEEEEEEDGAAVAEKSHRRAEM 696
+ +E+EE+ G + + A+M
Sbjct: 458 QEEMMQEQEEKMGEQEGKMCEQEAKM 483
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 91.7 bits (226), Expect = 2e-18
Identities = 91/396 (22%), Positives = 170/396 (42%), Gaps = 30/396 (7%)
Query: 307 PTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEM--EQVGQAEHLE---EEH 361
P +E + + ++++ + +E QV E+ + E+E EQ GQ E E
Sbjct: 47 PLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 106
Query: 362 DPSPEEQDREWKEQH----EQREAANLLEGHAR---AEVYPSAKPMIKFQSPYEEQLEQQ 414
+ EQ+ + +EQ EQ EG R +V + + + EQ Q
Sbjct: 107 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 166
Query: 415 RLAVQQVEEAQ-QLREHQEALHQQRLQGHLLRQQ----EQQQQQVAREMALQRQAELEEG 469
R QV E + Q+RE + + +Q +G + Q+ EQ++Q +E +Q+Q EE
Sbjct: 167 REQEGQVREQEGQVREQEGQVREQ--EGQMGEQEGQMGEQEEQMGEQEEQMQKQ---EEQ 221
Query: 470 RPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQ 529
+ +EQ+R+Q + VQ E+Q +Q +E + + E E + E +
Sbjct: 222 MGEQEEQMRKQEEQMGEQEEQVQKQEEQ-VQKQEEQMRKQEEQMREQEEQMREQEEQMLK 280
Query: 530 GPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQEN 589
+ + E + + + Q E E+ EQ+RE+ +E++ QK++
Sbjct: 281 QKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQM 340
Query: 590 TEVEEHL----VMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGEND 645
E +E + G ++Q +EQ +++ E+ +++ K+ E EE GE
Sbjct: 341 WEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQK 400
Query: 646 ENTDDKNNDGEEQEVR---DDNRPKGREEHYEEEEE 678
E ++ EQE + + + +EEH E++E
Sbjct: 401 EQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 91.3 bits (225), Expect = 3e-18
Identities = 103/486 (21%), Positives = 213/486 (43%), Gaps = 64/486 (13%)
Query: 120 MLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEK---EQELSKLKETVY 176
M + +EELK+++++L+EE + + S K+ +L+ +K QE +++E
Sbjct: 1 MPRITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQE-GQVREQEG 59
Query: 177 NLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQ 236
+RE+ Q+R+ + Q V++Q + + Q + + + + + QV E +
Sbjct: 60 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ----VREQEGQVREQEGQVREQE- 114
Query: 237 LKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVP 296
+R+ + ++ QV +G +E RE + R + +
Sbjct: 115 --------GQVREQEGQVREQEGQV-REQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 165
Query: 297 GRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEH 356
R ++ ++ +E E Q +QE + RE E E+E + E+ EQ+G+ E
Sbjct: 166 VREQEGQV-----REQEGQVR----EQEGQVREQEGQMGEQEGQMG---EQEEQMGEQEE 213
Query: 357 LEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRL 416
++ + EQ+ + ++Q EQ EEQ+++Q
Sbjct: 214 QMQKQEEQMGEQEEQMRKQEEQ-------------------------MGEQEEQVQKQEE 248
Query: 417 AVQQVEE-----AQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRP 471
VQ+ EE +Q+RE +E + +Q Q +L+Q+EQ +Q+ ++ E EE
Sbjct: 249 QVQKQEEQMRKQEEQMREQEEQMREQEEQ--MLKQKEQTEQEEQTGEQEEQMREQEEQMR 306
Query: 472 QHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGP 531
+ +EQ+R+Q + + E+Q + +E +E+ Q + E G + E ++
Sbjct: 307 EQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEE-QMGEQEEQMQKQE 365
Query: 532 READPESEADRAAVEDINPADDPNNQGEDEF-EEAEQVREENLPDENEEQKQSNQKQENT 590
+ + E R E + ++ + E++ E+ EQ+ E+ +E++ QK++
Sbjct: 366 EQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMR 425
Query: 591 EVEEHL 596
+ EEH+
Sbjct: 426 KQEEHM 431
Score = 89.7 bits (221), Expect = 8e-18
Identities = 91/382 (23%), Positives = 172/382 (45%), Gaps = 25/382 (6%)
Query: 320 PIQQEVERREPEEHQVEEEHRKALEEEEM--EQVGQAEHLE---EEHDPSPEEQDREWKE 374
P+ QE + RE +E QV E+ + E+E EQ GQ E E + EQ+ + +E
Sbjct: 47 PLPQEGQVRE-QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 105
Query: 375 QH----EQREAANLLEGHAR---AEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQ-Q 426
Q EQ EG R +V + + + EQ Q R QV E + Q
Sbjct: 106 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 165
Query: 427 LREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQ--RQAELEEGRPQHQEQLRQQAHYD 484
+RE + + +Q Q +R+QE Q ++ +M Q + E EE + +EQ+++Q
Sbjct: 166 VREQEGQVREQEGQ---VREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQM 222
Query: 485 AMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAA 544
+ ++ E+Q + EE +++ Q Q + E + REQ + + E + +
Sbjct: 223 GEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQK 282
Query: 545 VEDINPADDPNNQGEDEFEEAEQVRE--ENLPDENE---EQKQSNQKQENTEVEEHLVMA 599
E + Q E E+ EQ+RE E + ++ E EQ++ KQE E+ M
Sbjct: 283 -EQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMW 341
Query: 600 GNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQE 659
+Q ++ ++E + + QE+ +++ ++ E+ + ++ + GE++E
Sbjct: 342 EQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKE 401
Query: 660 VRDDNRPKGREEHYEEEEEEEE 681
+ + + RE+ + E++E+
Sbjct: 402 QMGEQKEQMREQEEQMGEQKEQ 423
Score = 89.4 bits (220), Expect = 1e-17
Identities = 91/444 (20%), Positives = 195/444 (43%), Gaps = 34/444 (7%)
Query: 51 QQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSR 110
++ L +LQ+V +S ++ +++ + +K + D + E Q +G+
Sbjct: 10 KEKNAELQEELQLVETEKSEIQLHIKELK---RKLETDKIPLPQEGQVREQEGQ------ 60
Query: 111 YSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSK 170
+ Q ++ Q ++++Q + E+ + E + Q Q Q +EQE +
Sbjct: 61 ---VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE-GQ 116
Query: 171 LKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQ 230
++E +RE+ Q+R+ + Q V++Q + + Q+ + + + + Q
Sbjct: 117 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV----REQEGQVREQEGQ 172
Query: 231 VAEYK-QLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVW 289
V E + Q+++ ++ R+ + + Q+ + E+ ++ +++ +
Sbjct: 173 VREQEGQVREQEGQV---REQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQM 229
Query: 290 QNHEAVPGRAEDT--KLYAPTHKEAEFQAPPEPI--QQEVERREPEEHQVEEEHRKALEE 345
+ E G E+ K K+ E E +QE + RE EE ++++ + EE
Sbjct: 230 RKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEE 289
Query: 346 EEMEQVGQAEHLEE---EHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIK 402
+ EQ Q EE E + EQ+ + +EQ EQ + +++ + M K
Sbjct: 290 QTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWK 349
Query: 403 FQSPYEEQLEQQRLAVQQV-EEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQ 461
+ EQ EQ + +QV ++ +Q+R+ +E Q R Q +R+QE+Q + +M Q
Sbjct: 350 QEEQMGEQEEQMQKQEEQVRKQEEQMRKQEE---QMRKQEEQMRKQEEQMGEQKEQMGEQ 406
Query: 462 RQ--AELEEGRPQHQEQLRQQAHY 483
++ E EE + +EQ+R+Q +
Sbjct: 407 KEQMREQEEQMGEQKEQMRKQEEH 430
Score = 87.0 bits (214), Expect = 5e-17
Identities = 98/468 (20%), Positives = 210/468 (44%), Gaps = 43/468 (9%)
Query: 179 REENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYK-QL 237
R N +L++ + ++ +LQ V+ + + ++L LE K L + QV E + Q+
Sbjct: 3 RITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQ-EGQVREQEGQV 61
Query: 238 KDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPG 297
++ ++ R+ + ++ QV +G +E RE + R + +
Sbjct: 62 REQEGQV---REQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQVREQEGQVREQEGQV 117
Query: 298 RAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHL 357
R ++ ++ +E + + ++++ + +E QV E+ + E+E QV + E
Sbjct: 118 REQEGQV---REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG--QVREQEGQ 172
Query: 358 EEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLA 417
E + EQ+ + +EQ Q G ++ + M K + EQ EQ R
Sbjct: 173 VREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQ 232
Query: 418 VQQV-EEAQQLREHQEALHQQ----RLQGHLLRQQEQQQQQVAREMALQR-QAELEEGRP 471
+Q+ E+ +Q+++ +E + +Q R Q +R+QE+Q ++ +M Q+ Q E EE
Sbjct: 233 EEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTG 292
Query: 472 QHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGP 531
+ +EQ+R+Q + ++ E+Q + EE +++ Q ++ E E +EQ
Sbjct: 293 EQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKE----QMWEQKEQMW 348
Query: 532 READPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTE 591
++ + E Q E ++ EQVR++ +E++ Q+++ +
Sbjct: 349 KQEEQMGE-----------------QEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRK 391
Query: 592 VEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEE 639
EE + +Q+E +++ Q +EE + E+ +++ EH E+
Sbjct: 392 QEEQM-----GEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQ 434
Score = 79.0 bits (193), Expect = 1e-14
Identities = 76/327 (23%), Positives = 141/327 (43%), Gaps = 20/327 (6%)
Query: 365 PEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMI------KFQSPYEEQLEQQRLAV 418
P + E KE++ + + L ++E+ K + K P E Q+ +Q V
Sbjct: 2 PRITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQV 61
Query: 419 QQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQE-QL 477
+ E+ Q+RE + + +Q +G + Q+ Q ++Q + + Q +EG+ + QE Q+
Sbjct: 62 R--EQEGQVREQEGQVREQ--EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 117
Query: 478 RQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPE 537
R+Q V+ E Q ++ +EG E EG R + + +E
Sbjct: 118 REQEGQVREQEGQVREQEGQ-VREQEGQVREQEGQVREQEGQV--REQEGQVREQEGQVR 174
Query: 538 SEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLV 597
+ + ++ + GE E + EQ E E EEQ Q ++Q + E+
Sbjct: 175 EQEGQVREQEGQVREQEGQMGEQEGQMGEQ---EEQMGEQEEQMQKQEEQMGEQEEQMRK 231
Query: 598 MAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELE---HNAEETYGENDENTDDKNND 654
+QE+ V +Q ++ ++E Q EE+ RE E EE + E T+ +
Sbjct: 232 QEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQT 291
Query: 655 GEEQEVRDDNRPKGREEHYEEEEEEEE 681
GE++E + + RE+ + E+EE+
Sbjct: 292 GEQEEQMREQEEQMREQEEQMREQEEQ 318
Score = 65.9 bits (159), Expect = 1e-10
Identities = 41/211 (19%), Positives = 101/211 (47%), Gaps = 21/211 (9%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKL 94
E + Q+RK E + ++ + Q+Q E + E+ ++++ + ++ +E L K
Sbjct: 224 EQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKE 283
Query: 95 EAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHK 154
+ ++ G Q+ R Q + ++ Q E++++Q + E+ + G+ + + +
Sbjct: 284 QTEQEEQTGEQEEQMR-----EQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKE 338
Query: 155 QKYLQLQQ---------EKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKN 205
Q + Q +Q E+E+++ K +E V R++ Q+RK + + Q + +++Q +
Sbjct: 339 QMWEQKEQMWKQEEQMGEQEEQMQKQEEQV---RKQEEQMRKQEEQMRKQEEQMRKQEEQ 395
Query: 206 LLSEHEQLVVTLEDHKSALAAAQTQVAEYKQ 236
+ + EQ + + K + + Q+ E K+
Sbjct: 396 MGEQKEQ----MGEQKEQMREQEEQMGEQKE 422
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 91.3 bits (225), Expect = 3e-18
Identities = 118/540 (21%), Positives = 234/540 (43%), Gaps = 25/540 (4%)
Query: 162 QEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDH- 220
Q +E +L+ V+ +R Q + ++ VKQ L E L+ L D
Sbjct: 116 QHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQ----LEGEARDLISRLHDSW 171
Query: 221 KSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQ 280
K A Q A Q K I L K A + + + + K ++Q
Sbjct: 172 KFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQ 231
Query: 281 EV-SRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPE-EHQVEE- 337
V S +++ N + + + E KL P + + QA + + +E++ + + QVEE
Sbjct: 232 LVESEKSEIQLNVKELKRKLERAKLLLP---QQQLQAEADHLGKELQSVSAKLQAQVEEN 288
Query: 338 EHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQ-REAANLLEGHARAEVYPS 396
E L +++ E++ + E +E + +EQ+ + +EQ E+ RE +
Sbjct: 289 ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE 348
Query: 397 AKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAR 456
K + + +E++ + +RL E+ +++RE +E +H+Q +R+QE+++Q+ +
Sbjct: 349 EKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEK----IREQEEKRQEEEK 404
Query: 457 EMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEA 516
+++ E E + +E++R+Q + E++ + E+ E Q Q+E
Sbjct: 405 IREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEM 464
Query: 517 EGDPGNRHEPRE-QGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQV---REEN 572
E E +E E E R E + ++ + E++ E E+ +EE
Sbjct: 465 WRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEK 524
Query: 573 LPDENE---EQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEK 629
+ ++ E EQ++ ++QE E+ M ++ ++ + QEE E +E + E+K
Sbjct: 525 IREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQK 584
Query: 630 KRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVAEK 689
++ E EE E +E ++ +EQE + + + E E+ +E+EE EK
Sbjct: 585 EKIREQ--EEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 642
Score = 90.9 bits (224), Expect = 4e-18
Identities = 132/658 (20%), Positives = 286/658 (43%), Gaps = 73/658 (11%)
Query: 51 QQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSR 110
+ Q L+ + + +H + S+ + KK K + ET G S
Sbjct: 54 ETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKK----INNGTNPETTTSGGCHSPED 109
Query: 111 YSALNVQHQMLKSQHEELKKQ-HSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELS 169
+ QHQ ++ EL+ Q H+ +K + ++ H K QL+ E +S
Sbjct: 110 EQKASHQHQ--EALRRELEAQVHTIRILTCQKTELQMALYYSQHAVK--QLEGEARDLIS 165
Query: 170 KLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVV-----TLEDH---- 220
+L ++ E L +A + TQ + + + L E + L + T+ D
Sbjct: 166 RLHDSWKFAGE----LEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKE 221
Query: 221 KSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPA-----EQQNVTQVAHSPQGYNTAREKP 275
K+A + Q+ E ++ + LN RK + A +QQ + H + + K
Sbjct: 222 KNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKL 281
Query: 276 TREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQV 335
+V+E N++W + ++ K++ K E++ E IQ++ E+ +E ++
Sbjct: 282 QAQVEE----NELWNRLN----QQQEEKMWRQEEKIQEWE---EKIQEQEEKIREQEEKI 330
Query: 336 EEEHRKALEEEEM------EQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHA 389
E+ K +EEM + Q E + E+ + ++ W+++ + RE L E
Sbjct: 331 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRE---LEEKMH 387
Query: 390 RAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQ 449
E + + + EQ ++Q + + +++RE +E + +Q + + RQ+E+
Sbjct: 388 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKK--MWRQEEK 445
Query: 450 --QQQQVAREMALQRQAEL--EEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGA 505
+Q+++ E Q Q E+ +E + + QE++ +Q + + ++ E++ + EE
Sbjct: 446 IHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKE-KMHEQEKIRKQEEKVWRQEEKM 504
Query: 506 YERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEA 565
++++ + +++ E + REQ + + E E R E + ++ + E++ +E
Sbjct: 505 HDQEEKIREQEEKMWRQEEKIREQEEKIREQE-EKIREQEEMMQEQEEKMGEQEEKMQEQ 563
Query: 566 EQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDL 625
E++R + +E+K QK++ E EE + +QE+ + EQ E++
Sbjct: 564 EKMRRQEEKIREQEEKIREQKEKIREQEEKIW------EQEEKIREQ----------EEM 607
Query: 626 TEEKKRELEHNAEETYGEND--ENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEE 681
+E++ ++ E+ + + + ++K EE+ + R + +EE +E +E E
Sbjct: 608 MQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 90.5 bits (223), Expect = 5e-18
Identities = 87/472 (18%), Positives = 221/472 (46%), Gaps = 47/472 (9%)
Query: 39 QLRKAEAVALKYQQHQESLSAQLQV-VYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQ 97
+L++ A + Q ES +++Q+ V E + +LE++ + +A+ D L +L++
Sbjct: 218 ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 277
Query: 98 ETLNKGRQDSNSRYSALNVQHQ---------------MLKSQHEELKKQHSDLEEEHRK- 141
+ + + N ++ LN Q + ++ Q E++++Q + E+ K
Sbjct: 278 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKM 337
Query: 142 -QGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLR-KAHQDIHTQLQDV 199
+ E+ + ++ ++ EKE+++ +L+E ++ E+ R+L K H+ + Q+
Sbjct: 338 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEE 397
Query: 200 KQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVT 259
K+Q + + E E+ ++ ++ + + ++ E ++ + ++ EQ+ +
Sbjct: 398 KRQEEEKIREQEKR----QEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIR 453
Query: 260 QVAHSPQGYNTAREKPTREVQEVSRNNDVWQN----HEAVPGRAEDTKLYAPTHKEAEFQ 315
+ + +E+ R+ +++ ++W+ HE R ++ K++ +E +
Sbjct: 454 EEEKRQE-----QEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVW---RQEEKMH 505
Query: 316 APPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQ 375
E I+++ E+ +E ++ E+ K E+EE ++ + E + +E + EQ+ + +EQ
Sbjct: 506 DQEEKIREQEEKMWRQEEKIREQEEKIREQEE--KIREQEEMMQEQEEKMGEQEEKMQEQ 563
Query: 376 HEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALH 435
+ R + + E K I+ Q EE++ +Q +++ EE ++E +E +
Sbjct: 564 EKMRRQEEKIR--EQEEKIREQKEKIREQ---EEKIWEQEEKIREQEE--MMQEQEEKMW 616
Query: 436 QQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMD 487
+Q + +QE++ Q+ +M Q + E+ Q++ + Q H + ++
Sbjct: 617 EQE---EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 87.8 bits (216), Expect = 3e-17
Identities = 80/414 (19%), Positives = 194/414 (46%), Gaps = 42/414 (10%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKL 94
+LQ Q+ + E QQ +E + Q + + E ++++ +K R + +K +E K+
Sbjct: 280 KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ--EEKM 337
Query: 95 EAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHK 154
QE + +++ R Q +M+ + E++++ + E+ K E + H+
Sbjct: 338 RRQEEMMWEKEEKMRR------QEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKM---HE 388
Query: 155 QKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSE----H 210
Q+ ++ Q+EK QE K++E +E + R+ + I Q + +++Q K + + H
Sbjct: 389 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ-EEKIREQEEKIREQEKKMWRQEEKIH 447
Query: 211 EQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNT 270
EQ + E+ + Q + ++ ++ + + + + +Q + ++
Sbjct: 448 EQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHD- 506
Query: 271 AREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREP 330
+E+ RE +E +W+ E + R ++ K+ +E + + E +Q++ E+
Sbjct: 507 -QEEKIREQEE-----KMWRQEEKI--REQEEKI---REQEEKIREQEEMMQEQEEKMGE 555
Query: 331 EEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHAR 390
+E +++E+ + +EE++ + Q E + E+ + E++++ W+++ + RE +++
Sbjct: 556 QEEKMQEQEKMRRQEEKIRE--QEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQ-EQE 612
Query: 391 AEVYPSAKPMIKFQSPYEEQLEQQRLAV-----------QQVEEAQQLREHQEA 433
+++ + M + + +EQ E+ R QQ E+ Q+ +EH EA
Sbjct: 613 EKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 666
Score = 72.8 bits (177), Expect = 1e-12
Identities = 100/514 (19%), Positives = 221/514 (42%), Gaps = 72/514 (14%)
Query: 197 QDVKQQHKNLLSE------HEQLVVTLEDHKSALAAAQTQVAEYKQL----KDTLNRIPS 246
Q QH+ L H ++T + + +A +Q A KQL +D ++R+
Sbjct: 111 QKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHA-VKQLEGEARDLISRLHD 169
Query: 247 LRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYA 306
K +Q ++ VA T ++K R ++E+++ D A +LY
Sbjct: 170 SWKFAGELEQALSAVA-------TQKKKADRYIEELTKERD-----------ALSLELYR 211
Query: 307 PTHKEAEFQAPPEPIQQEVERREPEEHQVE---EEHRKALEEEEMEQVGQAEHLEEEH-D 362
T + E + +Q++++ E E+ +++ +E ++ LE ++ Q E +H
Sbjct: 212 NTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 271
Query: 363 PSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVE 422
+ + + Q E+ E N L +++ + + +++ +EQ E+ R E
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIR------E 325
Query: 423 EAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAH 482
+ +++RE +E + +Q ++ ++Q+++ E ++ LEE + +E++R+
Sbjct: 326 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE-EKMRRLEEMMWEKEEKIREL-- 382
Query: 483 YDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADR 542
++ + +E E++ + Q+E + E R++ + + E R
Sbjct: 383 -------------EEKMHEQEKIREQEEKRQEE---EKIREQEKRQEQEAKMWRQEEKIR 426
Query: 543 AAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNP 602
E I + + E++ E E++REE ++ +EQ++ +++E +E +
Sbjct: 427 EQEEKIREQEKKMWRQEEKIHEQEKIREE---EKRQEQEEMWRQEEKIREQEEIW----- 478
Query: 603 DQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRD 662
+Q++ + EQ + +EE ++ E H+ EE E +E + EQE +
Sbjct: 479 -RQKEKMHEQEKIRKQEE-----KVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKI 532
Query: 663 DNRPKGREEHYEEEEEEEEDGAAVAEKSHRRAEM 696
+ + E E +E+EE EK + +M
Sbjct: 533 REQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKM 566
Score = 63.5 bits (153), Expect = 6e-10
Identities = 62/337 (18%), Positives = 151/337 (44%), Gaps = 38/337 (11%)
Query: 32 LYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLV 91
+ +E + ++R+ E + + ++ L ++ + R + EK ++E++ ++ +++
Sbjct: 357 MMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE--- 413
Query: 92 YKLEAQETLNKGRQDSNSRYSALNVQHQMLKS--QHEELKKQHSDLEEEHRKQGEDFSRT 149
+ RQ+ R ++ Q K Q E++ +Q EEE R++ E+ R
Sbjct: 414 ------QEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ 467
Query: 150 FND-HKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLS 208
+Q+ + Q+EK E K +R++ ++ + + +H Q + +++Q + +
Sbjct: 468 EEKIREQEEIWRQKEKMHEQEK-------IRKQEEKVWRQEEKMHDQEEKIREQEEKMWR 520
Query: 209 EHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGY 268
+ E+ + + + + + ++ E +++ ++ EQ+ + + +
Sbjct: 521 QEEK----IREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIR-- 574
Query: 269 NTAREKPTREVQEVSRNND--VWQNHEAVPGRAE-----DTKLYAPTHKEAEFQAPPEPI 321
+E+ RE +E R + +W+ E + + E + K++ K E + +
Sbjct: 575 --EQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ-- 630
Query: 322 QQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLE 358
+QE + R EE E+E R +EE+M++ EHLE
Sbjct: 631 EQEEKMRRQEEKMWEQEVRLRQQEEKMQE--HQEHLE 665
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 91.3 bits (225), Expect = 3e-18
Identities = 144/682 (21%), Positives = 277/682 (40%), Gaps = 89/682 (13%)
Query: 40 LRKAEAVALKYQQHQESLSAQLQ-----VVYEHRSRLEKSLQKERLEHKK-AKEDFLVYK 93
L +AE A+K + SLS+QLQ + E R +L S + +LE ++ + +D L +
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1355
Query: 94 LEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEE---EHRKQGEDFSRTF 150
+EA++ L + S LN+Q K + ++ LEE +K+ E+ ++ +
Sbjct: 1356 MEAKQNLER-------HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1408
Query: 151 NDHKQKYLQLQQEK---EQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLL 207
+ Y +L++ K +QEL L + N R+ L K + L + K
Sbjct: 1409 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468
Query: 208 SEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQ--------QNVT 259
E ++ + ++ + + E + K+ L R + K + + +NV
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1528
Query: 260 QVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPE 319
++ S + T E+ +++E+ D Q E R E E + QA E
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELE---DELQATEDAKLRLEVNMQALKGQFERDLQARDE 1585
Query: 320 PIQQEVERREPEEHQVEEEHRKALEEEEMEQV----------GQAEHLEEEHDPSPEEQD 369
+++ + + + H+ E E LE+E ++ G + LE + D + + ++
Sbjct: 1586 QNEEKRRQLQRQLHEYETE----LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641
Query: 370 REWKE----QHEQREAANLLEGH--ARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEE 423
K+ Q + ++ LE +R E++ +AK E ++ A +
Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK-------------ENEKKAKSLEAD 1688
Query: 424 AQQLREHQEALHQQRLQGHLLRQQ--EQQQQQVAREMALQRQAELEEGR-PQHQEQLRQ- 479
QL+E A + R Q L +++ E+ ++ ALQ + E R Q +E+L +
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1748
Query: 480 QAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESE 539
Q + +AM + + + + E A ER ++E+ R +E + + E
Sbjct: 1749 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN-KELRSKLHEMEGA 1807
Query: 540 ADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMA 599
I + Q E++ E+ + RE+ ++ +QK K+ +VE+ MA
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQ--EAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1865
Query: 600 GNPDQQEDNVDEQYQEEAEE--------EVQEDLTEEKKRELEHNAEETYGENDENTDDK 651
EQY+E+AE+ + Q + EE+ + + N + E DE T+
Sbjct: 1866 -----------EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1914
Query: 652 NNDGEEQEVRDDNRPKGREEHY 673
G E +G E +
Sbjct: 1915 EAMGREVNALKSKLRRGNETSF 1936
Score = 86.3 bits (212), Expect = 9e-17
Identities = 159/744 (21%), Positives = 301/744 (40%), Gaps = 122/744 (16%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKL 94
EL+ L + EA + + + L A+ + + + LE+ L++E + A++ + K+
Sbjct: 919 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE----EAARQKLQLEKV 974
Query: 95 EAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHK 154
A+ + K + ++ Q+ L + + L+++ SDL ++ E+ ++ K
Sbjct: 975 TAEAKIKKLEDE----ILVMDDQNNKLSKERKLLEERISDLTTNLAEE-EEKAKNLTKLK 1029
Query: 155 QKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLV 214
K+ + E E L K +++ L + R+L D H Q+ D++ Q L QL
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM---QLA 1086
Query: 215 VTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREK 274
E+ ++ALA ++A Q + L +I L + +++ + AR K
Sbjct: 1087 KKEEELQAALARLDDEIA---QKNNALKKIREL-------EGHISDLQEDLDSERAARNK 1136
Query: 275 PTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPE------PIQQEVERR 328
++ D+ + EA+ EDT T +E + E + +E
Sbjct: 1137 AEKQ------KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 329 EPEEHQVEEEHRKALEE--EEMEQ----------------------------VGQA---- 354
E + ++ ++H +A+EE E++EQ +GQA
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 355 EHLEEEHDPSPEE---------------QDREWKEQHEQREAANLLEGHARAEVYPSAKP 399
EH +++ + +E D+ K Q+E +L A + AK
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN-EAEGKAIKLAKD 1309
Query: 400 MIKFQSPYEEQLE------QQRLAV----QQVEEAQ-----QLREHQEALHQQRLQGHL- 443
+ S ++ E +Q+L V +Q+EE + QL E EA +Q L+ H+
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA--KQNLERHIS 1367
Query: 444 -LRQQEQQQQQVAREMALQRQAELEEGRPQHQ---EQLRQQAHYDAMDNDIVQGAEDQGI 499
L Q ++ ++ A +A LEEG+ + Q E L QQ A D ++ +++
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEA-LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426
Query: 500 QG-EEGAYERDNQHQDEAEGDPGNRH------EPREQGPREADPESEADRAAVEDINPAD 552
Q ++ + DNQ Q + + R E + + AD A+ A E A
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 553 DPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQ 612
E+ E E++ N + E + + K + + L + + + +
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546
Query: 613 YQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEH 672
EE E+E+Q TE+ K LE N + G+ + + ++ EE+ R R+ H
Sbjct: 1547 QLEELEDELQA--TEDAKLRLEVNMQALKGQFERDLQARDEQNEEK-----RRQLQRQLH 1599
Query: 673 -YEEEEEEEEDGAAVAEKSHRRAE 695
YE E E+E A+A + ++ E
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLE 1623
Score = 63.9 bits (154), Expect = 5e-10
Identities = 118/526 (22%), Positives = 217/526 (41%), Gaps = 47/526 (8%)
Query: 40 LRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQET 99
L + + ++ KY ++ A+ + L ++L+ E LE K+ E E
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALE-EALEAKEELERTNKMLKAEMED 1515
Query: 100 LNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQ 159
L + D L + L++Q EE+K Q +LE+E + ED + Q
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT-EDAKLRLEVNMQA--- 1571
Query: 160 LQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLED 219
L+ + E++L E E+ RQL++ + T+L+D ++Q + ++L L+D
Sbjct: 1572 LKGQFERDLQARDE---QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 220 -HKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTRE 278
A +A + + KQL+ ++ + K E ++ A + + TA+E E
Sbjct: 1629 LELQADSAIKGREEAIKQLR----KLQAQMKDFQRELEDAR--ASRDEIFATAKE---NE 1679
Query: 279 VQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKE------AEFQAPPEPIQQEVERREPEE 332
+ S D+ Q E + AE + A KE A + +Q E R E
Sbjct: 1680 KKAKSLEADLMQLQEDL-AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1738
Query: 333 HQVEEE------HRKALEEEEMEQVGQAEHLEEE--HDPSPEEQDREWKEQHEQ-----R 379
Q+EEE + +A+ + + QAE L E + S +++ ++Q E+ R
Sbjct: 1739 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1798
Query: 380 EAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEA--QQLREHQEALHQQ 437
+ +EG +++ + + + EEQ+EQ+ Q ++ Q+ ++ +E L Q
Sbjct: 1799 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV 1858
Query: 438 RLQGHLLRQ-QEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAED 496
+ + Q +EQ ++ AR L+RQ E E +E R A+ + ++ + E
Sbjct: 1859 EDERKMAEQYKEQAEKGNARVKQLKRQLEEAE-----EESQRINANRRKLQRELDEATES 1913
Query: 497 QGIQGEE-GAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEAD 541
G E A + + +E P R R E E D
Sbjct: 1914 NEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETD 1959
Score = 51.2 bits (121), Expect = 3e-06
Identities = 105/541 (19%), Positives = 216/541 (39%), Gaps = 52/541 (9%)
Query: 136 EEEHRKQGEDFSRTFNDHKQKY---LQLQQEKEQELSKLKETVYNLREENRQLRKAHQDI 192
+EE + ED + + +QK L+ ++K +L++ K + + +L +++
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909
Query: 193 HTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDP 252
+L KQ+ + +L E E + ED L A + ++A+ L+ L + +
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ-----QMLDLEEQLEEEEA 964
Query: 253 AEQQNVTQVAHSPQGYNTAREKPTREVQEV----SRNNDVWQNHEAVPGRAEDTKLYAPT 308
A Q+ + TA K + E+ +NN + + + + R D
Sbjct: 965 ARQKLQLEKV-------TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 309 HKE-----AEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEE---E 360
+E + + E + E+E R + EE+ R+ LE+ + + G A E +
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKK----EEKSRQELEKLKRKLEGDASDFHEQIAD 1073
Query: 361 HDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQ---SPYEEQLEQQRLA 417
E + ++ E+ +AA A+ + K + + + S +E L+ +R A
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1133
Query: 418 VQQVE-EAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQ-RQAELEEGRPQHQE 475
+ E + + L E EAL + L+ L QQ+ + RE + + L+E H+
Sbjct: 1134 RNKAEKQKRDLGEELEAL-KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1192
Query: 476 QLRQ--QAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPRE 533
Q+++ Q H A++ ++ + E + + +++ Q ++ D Q +E
Sbjct: 1193 QVQEMRQKHAQAVE-ELTEQLEQ--FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249
Query: 534 ADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVE 593
+ + + A V+++ + E + + L +E E + E ++
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELND----KVHKLQNEVESVTGMLNEAEGKAIK 1305
Query: 594 EHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDL-TEEKKRELEHNAEETYGENDENTDDKN 652
+A Q +D QE +EE ++ L K R+LE + DE + K
Sbjct: 1306 LAKDVASLSSQLQDT-----QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360
Query: 653 N 653
N
Sbjct: 1361 N 1361
Score = 50.8 bits (120), Expect = 4e-06
Identities = 78/379 (20%), Positives = 147/379 (38%), Gaps = 44/379 (11%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQ----LQVVYEHRSRLEKSLQKERLEHKKAKEDFL 90
EL+ +L+ E L+ + + ++L Q LQ E + LQ++ E++ ED
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609
Query: 91 VYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTF 150
+ A K D L +Q EE KQ L+ Q +DF R
Sbjct: 1610 KQRALAAAAKKKLEGDLKD----LELQADSAIKGREEAIKQLRKLQA----QMKDFQREL 1661
Query: 151 ND---HKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLL 207
D + + +E E++ L+ + L+E+ +A + + +++ ++ + L
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721
Query: 208 SEHE--------------QLVVTLEDHKSALAAAQTQVAEYKQLKDTL-NRIPSLR---- 248
S QL LE+ + + A +V + Q + L N + + R
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781
Query: 249 KPDPAEQQ------NVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDT 302
K + A QQ + H +G ++ K T E + Q E V A +
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK----IAQLEEQVEQEAREK 1837
Query: 303 KLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHD 362
+ + K+ + + +Q E ER+ E+++ + E A ++ Q+ +AE + +
Sbjct: 1838 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897
Query: 363 PSPEEQDREWKEQHEQREA 381
+ + RE E E EA
Sbjct: 1898 ANRRKLQRELDEATESNEA 1916
Score = 49.7 bits (117), Expect = 9e-06
Identities = 83/398 (20%), Positives = 160/398 (40%), Gaps = 47/398 (11%)
Query: 34 YELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQ-------------KERL 80
+EL+ R E + + E L +LQ + + RLE ++Q E+
Sbjct: 1528 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1587
Query: 81 EHKKAKEDFLVYKLEAQ-ETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEH 139
E K+ + +++ E + E K R + + L + L+ Q + K + ++
Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1647
Query: 140 RK---QGEDFSRTFND---HKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIH 193
RK Q +DF R D + + +E E++ L+ + L+E+ +A +
Sbjct: 1648 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707
Query: 194 TQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPA 253
+ +++ ++ + LS L+D K L A Q+ E +L++ + ++
Sbjct: 1708 LEKEELAEELASSLSGRN----ALQDEKRRLEARIAQLEE--ELEEEQGNMEAMSDRVRK 1761
Query: 254 EQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQN--HE---AVPGRAEDT------ 302
Q Q+++ + +K Q++ R N ++ HE AV + + T
Sbjct: 1762 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1821
Query: 303 ---KLYAPTHKEA-EFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQA---- 354
+L +EA E QA + ++Q+ ++ + QVE+E + A + +E + G A
Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1881
Query: 355 --EHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHAR 390
LEE + S K Q E EA E R
Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGR 1919
Score = 47.4 bits (111), Expect = 5e-05
Identities = 85/395 (21%), Positives = 156/395 (39%), Gaps = 74/395 (18%)
Query: 328 REPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEG 387
R+ EE Q +E+ + +E + + + + LE++H EE+ NLL+
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK--------------NLLQE 894
Query: 388 --HARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLR 445
A E+Y A+ M + RLA ++ E + L E + L ++ +G L
Sbjct: 895 QLQAETELYAEAEEM------------RVRLAAKKQELEEILHEMEARLEEEEDRGQQL- 941
Query: 446 QQEQQQQQVAREMALQRQAELEEGRPQ--HQEQLRQQAHYDAMDNDI-VQGAEDQGIQGE 502
Q ++++ + + L+ Q E EE Q E++ +A ++++I V ++ + E
Sbjct: 942 -QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1000
Query: 503 EGAYER------DNQHQDEAEGDP----GNRHEPREQGPREADPESEADRAAVEDI---- 548
E N ++E + N+HE + E R +E +
Sbjct: 1001 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060
Query: 549 -NPADDPNNQGEDEFEEAEQVREENLPDENEEQ-----------KQSNQKQENTEVEEHL 596
A D + Q D + +++ + E E Q +++N ++ E+E H+
Sbjct: 1061 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 597 VMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEE---KKRELEHNAEETYGEND-------E 646
D QED E+ E+ + DL EE K ELE + T + + E
Sbjct: 1121 -----SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1175
Query: 647 NTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEE 681
T K EE + + R++H + EE E
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 91.3 bits (225), Expect = 3e-18
Identities = 144/682 (21%), Positives = 277/682 (40%), Gaps = 89/682 (13%)
Query: 40 LRKAEAVALKYQQHQESLSAQLQ-----VVYEHRSRLEKSLQKERLEHKK-AKEDFLVYK 93
L +AE A+K + SLS+QLQ + E R +L S + +LE ++ + +D L +
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362
Query: 94 LEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEE---EHRKQGEDFSRTF 150
+EA++ L + S LN+Q K + ++ LEE +K+ E+ ++ +
Sbjct: 1363 MEAKQNLER-------HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1415
Query: 151 NDHKQKYLQLQQEK---EQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLL 207
+ Y +L++ K +QEL L + N R+ L K + L + K
Sbjct: 1416 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475
Query: 208 SEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQ--------QNVT 259
E ++ + ++ + + E + K+ L R + K + + +NV
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535
Query: 260 QVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPE 319
++ S + T E+ +++E+ D Q E R E E + QA E
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELE---DELQATEDAKLRLEVNMQALKGQFERDLQARDE 1592
Query: 320 PIQQEVERREPEEHQVEEEHRKALEEEEMEQV----------GQAEHLEEEHDPSPEEQD 369
+++ + + + H+ E E LE+E ++ G + LE + D + + ++
Sbjct: 1593 QNEEKRRQLQRQLHEYETE----LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648
Query: 370 REWKE----QHEQREAANLLEGH--ARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEE 423
K+ Q + ++ LE +R E++ +AK E ++ A +
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK-------------ENEKKAKSLEAD 1695
Query: 424 AQQLREHQEALHQQRLQGHLLRQQ--EQQQQQVAREMALQRQAELEEGR-PQHQEQLRQ- 479
QL+E A + R Q L +++ E+ ++ ALQ + E R Q +E+L +
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1755
Query: 480 QAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESE 539
Q + +AM + + + + E A ER ++E+ R +E + + E
Sbjct: 1756 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN-KELRSKLHEMEGA 1814
Query: 540 ADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMA 599
I + Q E++ E+ + RE+ ++ +QK K+ +VE+ MA
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQ--EAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1872
Query: 600 GNPDQQEDNVDEQYQEEAEE--------EVQEDLTEEKKRELEHNAEETYGENDENTDDK 651
EQY+E+AE+ + Q + EE+ + + N + E DE T+
Sbjct: 1873 -----------EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1921
Query: 652 NNDGEEQEVRDDNRPKGREEHY 673
G E +G E +
Sbjct: 1922 EAMGREVNALKSKLRRGNETSF 1943
Score = 86.3 bits (212), Expect = 9e-17
Identities = 159/744 (21%), Positives = 301/744 (40%), Gaps = 122/744 (16%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKL 94
EL+ L + EA + + + L A+ + + + LE+ L++E + A++ + K+
Sbjct: 926 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE----EAARQKLQLEKV 981
Query: 95 EAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHK 154
A+ + K + ++ Q+ L + + L+++ SDL ++ E+ ++ K
Sbjct: 982 TAEAKIKKLEDE----ILVMDDQNNKLSKERKLLEERISDLTTNLAEE-EEKAKNLTKLK 1036
Query: 155 QKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLV 214
K+ + E E L K +++ L + R+L D H Q+ D++ Q L QL
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM---QLA 1093
Query: 215 VTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREK 274
E+ ++ALA ++A Q + L +I L + +++ + AR K
Sbjct: 1094 KKEEELQAALARLDDEIA---QKNNALKKIREL-------EGHISDLQEDLDSERAARNK 1143
Query: 275 PTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPE------PIQQEVERR 328
++ D+ + EA+ EDT T +E + E + +E
Sbjct: 1144 AEKQ------KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 329 EPEEHQVEEEHRKALEE--EEMEQ----------------------------VGQA---- 354
E + ++ ++H +A+EE E++EQ +GQA
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 355 EHLEEEHDPSPEE---------------QDREWKEQHEQREAANLLEGHARAEVYPSAKP 399
EH +++ + +E D+ K Q+E +L A + AK
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN-EAEGKAIKLAKD 1316
Query: 400 MIKFQSPYEEQLE------QQRLAV----QQVEEAQ-----QLREHQEALHQQRLQGHL- 443
+ S ++ E +Q+L V +Q+EE + QL E EA +Q L+ H+
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA--KQNLERHIS 1374
Query: 444 -LRQQEQQQQQVAREMALQRQAELEEGRPQHQ---EQLRQQAHYDAMDNDIVQGAEDQGI 499
L Q ++ ++ A +A LEEG+ + Q E L QQ A D ++ +++
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEA-LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433
Query: 500 QG-EEGAYERDNQHQDEAEGDPGNRH------EPREQGPREADPESEADRAAVEDINPAD 552
Q ++ + DNQ Q + + R E + + AD A+ A E A
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 553 DPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQ 612
E+ E E++ N + E + + K + + L + + + +
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553
Query: 613 YQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEH 672
EE E+E+Q TE+ K LE N + G+ + + ++ EE+ R R+ H
Sbjct: 1554 QLEELEDELQA--TEDAKLRLEVNMQALKGQFERDLQARDEQNEEK-----RRQLQRQLH 1606
Query: 673 -YEEEEEEEEDGAAVAEKSHRRAE 695
YE E E+E A+A + ++ E
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLE 1630
Score = 63.9 bits (154), Expect = 5e-10
Identities = 118/526 (22%), Positives = 217/526 (41%), Gaps = 47/526 (8%)
Query: 40 LRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQET 99
L + + ++ KY ++ A+ + L ++L+ E LE K+ E E
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALE-EALEAKEELERTNKMLKAEMED 1522
Query: 100 LNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQ 159
L + D L + L++Q EE+K Q +LE+E + ED + Q
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT-EDAKLRLEVNMQA--- 1578
Query: 160 LQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLED 219
L+ + E++L E E+ RQL++ + T+L+D ++Q + ++L L+D
Sbjct: 1579 LKGQFERDLQARDE---QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 220 -HKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTRE 278
A +A + + KQL+ ++ + K E ++ A + + TA+E E
Sbjct: 1636 LELQADSAIKGREEAIKQLR----KLQAQMKDFQRELEDAR--ASRDEIFATAKE---NE 1686
Query: 279 VQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKE------AEFQAPPEPIQQEVERREPEE 332
+ S D+ Q E + AE + A KE A + +Q E R E
Sbjct: 1687 KKAKSLEADLMQLQEDL-AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1745
Query: 333 HQVEEE------HRKALEEEEMEQVGQAEHLEEE--HDPSPEEQDREWKEQHEQ-----R 379
Q+EEE + +A+ + + QAE L E + S +++ ++Q E+ R
Sbjct: 1746 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1805
Query: 380 EAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEA--QQLREHQEALHQQ 437
+ +EG +++ + + + EEQ+EQ+ Q ++ Q+ ++ +E L Q
Sbjct: 1806 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV 1865
Query: 438 RLQGHLLRQ-QEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAED 496
+ + Q +EQ ++ AR L+RQ E E +E R A+ + ++ + E
Sbjct: 1866 EDERKMAEQYKEQAEKGNARVKQLKRQLEEAE-----EESQRINANRRKLQRELDEATES 1920
Query: 497 QGIQGEE-GAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEAD 541
G E A + + +E P R R E E D
Sbjct: 1921 NEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETD 1966
Score = 51.2 bits (121), Expect = 3e-06
Identities = 105/541 (19%), Positives = 216/541 (39%), Gaps = 52/541 (9%)
Query: 136 EEEHRKQGEDFSRTFNDHKQKY---LQLQQEKEQELSKLKETVYNLREENRQLRKAHQDI 192
+EE + ED + + +QK L+ ++K +L++ K + + +L +++
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 193 HTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDP 252
+L KQ+ + +L E E + ED L A + ++A+ L+ L + +
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ-----QMLDLEEQLEEEEA 971
Query: 253 AEQQNVTQVAHSPQGYNTAREKPTREVQEV----SRNNDVWQNHEAVPGRAEDTKLYAPT 308
A Q+ + TA K + E+ +NN + + + + R D
Sbjct: 972 ARQKLQLEKV-------TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 309 HKE-----AEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEE---E 360
+E + + E + E+E R + EE+ R+ LE+ + + G A E +
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKK----EEKSRQELEKLKRKLEGDASDFHEQIAD 1080
Query: 361 HDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQ---SPYEEQLEQQRLA 417
E + ++ E+ +AA A+ + K + + + S +E L+ +R A
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1140
Query: 418 VQQVE-EAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQ-RQAELEEGRPQHQE 475
+ E + + L E EAL + L+ L QQ+ + RE + + L+E H+
Sbjct: 1141 RNKAEKQKRDLGEELEAL-KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1199
Query: 476 QLRQ--QAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPRE 533
Q+++ Q H A++ ++ + E + + +++ Q ++ D Q +E
Sbjct: 1200 QVQEMRQKHAQAVE-ELTEQLEQ--FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256
Query: 534 ADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVE 593
+ + + A V+++ + E + + L +E E + E ++
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELND----KVHKLQNEVESVTGMLNEAEGKAIK 1312
Query: 594 EHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDL-TEEKKRELEHNAEETYGENDENTDDKN 652
+A Q +D QE +EE ++ L K R+LE + DE + K
Sbjct: 1313 LAKDVASLSSQLQDT-----QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367
Query: 653 N 653
N
Sbjct: 1368 N 1368
Score = 50.8 bits (120), Expect = 4e-06
Identities = 78/379 (20%), Positives = 147/379 (38%), Gaps = 44/379 (11%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQ----LQVVYEHRSRLEKSLQKERLEHKKAKEDFL 90
EL+ +L+ E L+ + + ++L Q LQ E + LQ++ E++ ED
Sbjct: 1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616
Query: 91 VYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTF 150
+ A K D L +Q EE KQ L+ Q +DF R
Sbjct: 1617 KQRALAAAAKKKLEGDLKD----LELQADSAIKGREEAIKQLRKLQA----QMKDFQREL 1668
Query: 151 ND---HKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLL 207
D + + +E E++ L+ + L+E+ +A + + +++ ++ + L
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Query: 208 SEHE--------------QLVVTLEDHKSALAAAQTQVAEYKQLKDTL-NRIPSLR---- 248
S QL LE+ + + A +V + Q + L N + + R
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 249 KPDPAEQQ------NVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDT 302
K + A QQ + H +G ++ K T E + Q E V A +
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK----IAQLEEQVEQEAREK 1844
Query: 303 KLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHD 362
+ + K+ + + +Q E ER+ E+++ + E A ++ Q+ +AE + +
Sbjct: 1845 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904
Query: 363 PSPEEQDREWKEQHEQREA 381
+ + RE E E EA
Sbjct: 1905 ANRRKLQRELDEATESNEA 1923
Score = 49.7 bits (117), Expect = 9e-06
Identities = 83/398 (20%), Positives = 160/398 (40%), Gaps = 47/398 (11%)
Query: 34 YELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQ-------------KERL 80
+EL+ R E + + E L +LQ + + RLE ++Q E+
Sbjct: 1535 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1594
Query: 81 EHKKAKEDFLVYKLEAQ-ETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEH 139
E K+ + +++ E + E K R + + L + L+ Q + K + ++
Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1654
Query: 140 RK---QGEDFSRTFND---HKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIH 193
RK Q +DF R D + + +E E++ L+ + L+E+ +A +
Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Query: 194 TQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPA 253
+ +++ ++ + LS L+D K L A Q+ E +L++ + ++
Sbjct: 1715 LEKEELAEELASSLSGRN----ALQDEKRRLEARIAQLEE--ELEEEQGNMEAMSDRVRK 1768
Query: 254 EQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQN--HE---AVPGRAEDT------ 302
Q Q+++ + +K Q++ R N ++ HE AV + + T
Sbjct: 1769 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1828
Query: 303 ---KLYAPTHKEA-EFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQA---- 354
+L +EA E QA + ++Q+ ++ + QVE+E + A + +E + G A
Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1888
Query: 355 --EHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHAR 390
LEE + S K Q E EA E R
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGR 1926
Score = 47.4 bits (111), Expect = 5e-05
Identities = 85/395 (21%), Positives = 156/395 (39%), Gaps = 74/395 (18%)
Query: 328 REPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEG 387
R+ EE Q +E+ + +E + + + + LE++H EE+ NLL+
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK--------------NLLQE 901
Query: 388 --HARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLR 445
A E+Y A+ M + RLA ++ E + L E + L ++ +G L
Sbjct: 902 QLQAETELYAEAEEM------------RVRLAAKKQELEEILHEMEARLEEEEDRGQQL- 948
Query: 446 QQEQQQQQVAREMALQRQAELEEGRPQ--HQEQLRQQAHYDAMDNDI-VQGAEDQGIQGE 502
Q ++++ + + L+ Q E EE Q E++ +A ++++I V ++ + E
Sbjct: 949 -QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1007
Query: 503 EGAYER------DNQHQDEAEGDP----GNRHEPREQGPREADPESEADRAAVEDI---- 548
E N ++E + N+HE + E R +E +
Sbjct: 1008 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067
Query: 549 -NPADDPNNQGEDEFEEAEQVREENLPDENEEQ-----------KQSNQKQENTEVEEHL 596
A D + Q D + +++ + E E Q +++N ++ E+E H+
Sbjct: 1068 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 597 VMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEE---KKRELEHNAEETYGEND-------E 646
D QED E+ E+ + DL EE K ELE + T + + E
Sbjct: 1128 -----SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1182
Query: 647 NTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEE 681
T K EE + + R++H + EE E
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 90.1 bits (222), Expect = 6e-18
Identities = 131/664 (19%), Positives = 277/664 (41%), Gaps = 95/664 (14%)
Query: 51 QQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSR 110
+ Q L+ + + +H + S+ + KK K + ET G S
Sbjct: 115 ETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKK----INNGTNPETTTSGGCHSPED 170
Query: 111 YSALNVQHQMLKSQHEELKKQ-HSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELS 169
+ QHQ ++ EL+ Q H+ +K + ++ H K QL+ E +S
Sbjct: 171 EQKASHQHQ--EALRRELEAQVHTIRILTCQKTELQMALYYSQHAVK--QLEGEARDLIS 226
Query: 170 KLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVV-----TLEDH---- 220
+L ++ E L +A + TQ + + + L E + L + T+ D
Sbjct: 227 RLHDSWKFAGE----LEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKE 282
Query: 221 KSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPA-----EQQNVTQVAHSPQGYNTAREKP 275
K+A + Q+ E ++ + LN RK + A +QQ + H + + K
Sbjct: 283 KNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKL 342
Query: 276 TREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQV 335
+V+E N++W + ++ K++ K E++ E IQ++ E+ +E ++
Sbjct: 343 QAQVEE----NELWNRLN----QQQEEKMWRQEEKIQEWE---EKIQEQEEKIREQEEKI 391
Query: 336 EEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYP 395
E+ K +EEM + E+ + +++ W+++ + R ++
Sbjct: 392 REQEEKMRRQEEM--------MWEKEEKMRRQEEMMWEKEEKMRRQEEMMW--------- 434
Query: 396 SAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVA 455
E+ E+ R +++ E +++RE +E +R + +R+QE++Q+Q A
Sbjct: 435 -------------EKEEKIRELEEKMHEQEKIREQEE----KRQEEEKIREQEKRQEQEA 477
Query: 456 REMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDE 515
+ + + +E + + QE+ + + + ++ E + Q E E + Q+E
Sbjct: 478 KMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEE 537
Query: 516 AEGDPGNRHEPREQGPREADP----------ESEADRAAVEDINPADDPNNQGEDEF-EE 564
HE E+ ++ + + E R E + ++ + E++ E+
Sbjct: 538 IWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQ 597
Query: 565 AEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQED 624
E++RE+ + +E+K Q+++ E EE + +QE+ + Q ++ E+E +
Sbjct: 598 EEKIREQEEMTQEQEEKMGEQEEKMCEQEEKM------QEQEEKMRRQEEKIREQEKKIR 651
Query: 625 LTEEKKRELE---HNAEETYGENDE---NTDDKNNDGEEQEVRDDNRPKGREEHYEEEEE 678
EEK RE E EE E +E ++K + EE+ R + + +E ++EE
Sbjct: 652 EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 711
Query: 679 EEED 682
+ ++
Sbjct: 712 KMQE 715
Score = 84.0 bits (206), Expect = 4e-16
Identities = 84/404 (20%), Positives = 184/404 (45%), Gaps = 27/404 (6%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKL 94
+LQ Q+ + E QQ +E + Q + + E ++++ +K R + +K +E K+
Sbjct: 341 KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ--EEKM 398
Query: 95 EAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHK 154
QE + +++ R Q +M+ + E++++Q + E+ K E + H+
Sbjct: 399 RRQEEMMWEKEEKMRR------QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM---HE 449
Query: 155 QKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSE----H 210
Q+ ++ Q+EK QE K++E +E + R+ + I Q + +++Q + + + H
Sbjct: 450 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ-EEKIREQEEKIREQEEKMWRQEEKIH 508
Query: 211 EQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNT 270
EQ + E+ + Q + ++ ++ + + + + ++ ++ + +
Sbjct: 509 EQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHD 568
Query: 271 AREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREP 330
EK RE +E VW+ E + R ++ K+ K E + + +QE + E
Sbjct: 569 QEEK-IREQEE-----KVWRQEEKI--REQEEKIREQEEKIREQEEMTQ--EQEEKMGEQ 618
Query: 331 EEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHAR 390
EE E+E + +EE+M + + +E+ EE+ RE +E +++E +
Sbjct: 619 EEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 678
Query: 391 AEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEA-QQLREHQEA 433
E + + EE++ +Q + ++Q EE Q+ +EH EA
Sbjct: 679 CEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722
Score = 83.6 bits (205), Expect = 6e-16
Identities = 105/516 (20%), Positives = 217/516 (42%), Gaps = 63/516 (12%)
Query: 197 QDVKQQHKNLLSE------HEQLVVTLEDHKSALAAAQTQVAEYKQL----KDTLNRIPS 246
Q QH+ L H ++T + + +A +Q A KQL +D ++R+
Sbjct: 172 QKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHA-VKQLEGEARDLISRLHD 230
Query: 247 LRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYA 306
K +Q ++ VA T ++K R ++E+++ D A +LY
Sbjct: 231 SWKFAGELEQALSAVA-------TQKKKADRYIEELTKERD-----------ALSLELYR 272
Query: 307 PTHKEAEFQAPPEPIQQEVERREPEEHQVE---EEHRKALEEEEMEQVGQAEHLEEEH-D 362
T + E + +Q++++ E E+ +++ +E ++ LE ++ Q E +H
Sbjct: 273 NTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 332
Query: 363 PSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVE 422
+ + + Q E+ E N L +++ + + +++ +EQ E+ R +++
Sbjct: 333 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 392
Query: 423 EAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAH 482
E ++ QE + ++ + + + Q++ +E ++RQ E+ + + +L ++ H
Sbjct: 393 EQEEKMRRQEEMMWEKEE----KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH 448
Query: 483 YDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADR 542
+E E++ + Q+E + E R++ + + E R
Sbjct: 449 E------------------QEKIREQEEKRQEE---EKIREQEKRQEQEAKMWRQEEKIR 487
Query: 543 AAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNP 602
E I ++ + E++ E E++REE E EE + Q+++ E EE
Sbjct: 488 EQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWR--QEEKIREQEEIWRQKEKI 545
Query: 603 DQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNA---EETYGENDENTDDKNNDGEEQE 659
+QE+ + +Q ++ +E + EEK RE E EE E +E ++ EQE
Sbjct: 546 HEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQE 605
Query: 660 VRDDNRPKGREEHYEEEEEEEEDGAAVAEKSHRRAE 695
+ + E E+ E+EE EK R+ E
Sbjct: 606 EMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEE 641
Score = 82.4 bits (202), Expect = 1e-15
Identities = 83/477 (17%), Positives = 214/477 (44%), Gaps = 62/477 (12%)
Query: 39 QLRKAEAVALKYQQHQESLSAQLQV-VYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQ 97
+L++ A + Q ES +++Q+ V E + +LE++ + +A+ D L +L++
Sbjct: 279 ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 338
Query: 98 ETLNKGRQDSNSRYSALNVQHQ---------------MLKSQHEELKKQHSDLEEEHRK- 141
+ + + N ++ LN Q + ++ Q E++++Q + E+ K
Sbjct: 339 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKM 398
Query: 142 -QGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLR-KAHQDIHTQLQDV 199
+ E+ + ++ ++ EKE+++ + +E ++ E+ R+L K H+ + Q+
Sbjct: 399 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE 458
Query: 200 KQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVT 259
K+Q + + E E+ ++ ++ + + ++ E ++ K R+ + +Q
Sbjct: 459 KRQEEEKIREQEKR----QEQEAKMWRQEEKIREQEE-KIREQEEKMWRQEEKIHEQEKI 513
Query: 260 QVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPG-----RAEDTKLYAPTHK---- 310
+ Q +E+ R+ +++ ++W+ E + R ++ K++ K
Sbjct: 514 REEEKRQ----EQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQ 569
Query: 311 EAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDR 370
E + + E + ++ E+ +E ++ E+ K E+EEM Q + + E+E +E+
Sbjct: 570 EEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKM 629
Query: 371 EWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREH 430
+ +E+ +R+ + E E+++ +Q +++ EE ++E
Sbjct: 630 QEQEEKMRRQEEKIRE--------------------QEKKIREQEEKIREQEE--MMQEQ 667
Query: 431 QEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMD 487
+E + +Q + +QE++ Q+ +M Q + E+ Q++ + Q H + ++
Sbjct: 668 EEKMWEQE---EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 64.7 bits (156), Expect = 3e-10
Identities = 54/327 (16%), Positives = 148/327 (45%), Gaps = 23/327 (7%)
Query: 32 LYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLV 91
+ +E + ++R+ E + + ++ L ++ + R + EK ++E++ ++ ++
Sbjct: 418 MMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ---- 473
Query: 92 YKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFN 151
E + + + + + + Q + + Q E++ +Q EEE R++ E+ R
Sbjct: 474 ---EQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWR--- 527
Query: 152 DHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHE 211
+++ ++ Q+E ++ K+ E +R++ ++ + + +H Q + +++Q + + + E
Sbjct: 528 --QEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEE 585
Query: 212 QLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTA 271
+ + + + + + ++ E +++ ++ EQ+ Q
Sbjct: 586 K----IREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKM---RR 638
Query: 272 REKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPE 331
+E+ RE ++ R + + + ++ K++ K E + + +QE + R E
Sbjct: 639 QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ--EQEEKMRRQE 696
Query: 332 EHQVEEEHRKALEEEEMEQVGQAEHLE 358
E E+E R +EE+M++ EHLE
Sbjct: 697 EKMWEQEVRLRQQEEKMQE--HQEHLE 721
>gi|44890059 involucrin [Homo sapiens]
Length = 585
Score = 89.7 bits (221), Expect = 8e-18
Identities = 123/529 (23%), Positives = 226/529 (42%), Gaps = 74/529 (13%)
Query: 117 QHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVY 176
+ Q + Q +EL++QH + EE++K + QL+QEK Q +L
Sbjct: 76 EQQQKEPQEQELQQQHWEQHEEYQKA-----------ENPEQQLKQEKTQRDQQL----- 119
Query: 177 NLREENRQLRKAHQDIHTQL-QDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYK 235
N+QL + + + QL Q++ ++ + L + EQL+ E + L + Q
Sbjct: 120 -----NKQLEEEKKLLDQQLDQELVKRDEQLGMKKEQLLELPEQQEGHLKHLEQQEG--- 171
Query: 236 QLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAV 295
QLK + L P+ E Q P+ E P E QE Q +
Sbjct: 172 QLKHPEQQEGQLELPEQQEGQ-----LELPEQQEGQLELP--EQQEGQLELPEQQEGQLE 224
Query: 296 PGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEE-EHRKALEEEEMEQVGQA 354
++ +L P +E + + E + ++E E +E Q++ EH++ E EQ+GQ
Sbjct: 225 LPEQQEGQLELPQQQEGQLEL-SEQQEGQLELSEQQEGQLKHLEHQEGQLEVPEEQMGQL 283
Query: 355 EHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQ 414
++LE++ E Q + +Q +Q E G + ++ Q + LEQQ
Sbjct: 284 KYLEQQ-----EGQLKHLDQQEKQPELPEQQMGQLK---------HLEQQEGQPKHLEQQ 329
Query: 415 RLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQ 474
++Q+EE + +H L QQ Q L QE Q +++ +Q E ++G+P+H
Sbjct: 330 EGQLEQLEEQEGQLKH---LEQQEGQLEHLEHQEGQLGLPEQQVLQLKQLEKQQGQPKHL 386
Query: 475 EQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREA 534
E+ Q + + + Q + + + +EG E+ + + E G EQ +
Sbjct: 387 EEEEGQ-----LKHLVQQEGQLKHLVQQEGQLEQQERQVEHLEQQVGQLKHLEEQEGQLK 441
Query: 535 DPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEE 594
E + + V + P N ++E ++ LP++ E Q + +KQE ++E
Sbjct: 442 HLEQQQGQLEVPE-QQVGQPKNLEQEE-------KQLELPEQQEGQVKHLEKQE-AQLEL 492
Query: 595 HLVMAGNP---DQQEDNVDEQYQEEA------EEEVQEDLTEEKKRELE 634
G P +QQE +++ Q++ ++E Q E++K +LE
Sbjct: 493 PEQQVGQPKHLEQQEKHLEHPEQQDGQLKHLEQQEGQLKDLEQQKGQLE 541
Score = 82.0 bits (201), Expect = 2e-15
Identities = 108/487 (22%), Positives = 209/487 (42%), Gaps = 37/487 (7%)
Query: 37 QTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEA 96
Q + ++ E ++QH+E A+ E + + EK+ + ++L + +E L+ +
Sbjct: 79 QKEPQEQELQQQHWEQHEEYQKAENP---EQQLKQEKTQRDQQLNKQLEEEKKLLDQQLD 135
Query: 97 QETLNKGRQDSNSRYSALNVQHQM------LKSQHEELK---KQHSDLEEEHRKQGEDFS 147
QE + + Q + L + Q L+ Q +LK +Q LE +++G+
Sbjct: 136 QELVKRDEQLGMKKEQLLELPEQQEGHLKHLEQQEGQLKHPEQQEGQLELPEQQEGQ-LE 194
Query: 148 RTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNL- 206
Q L QQE + EL + +E L E+ + Q QL+ +QQ L
Sbjct: 195 LPEQQEGQLELPEQQEGQLELPEQQEGQLELPEQQEGQLELPQQQEGQLELSEQQEGQLE 254
Query: 207 LSEHEQ-LVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSL----RKPDPAEQQNVTQV 261
LSE ++ + LE + L + Q+ + K L+ ++ L ++P+ EQQ + Q+
Sbjct: 255 LSEQQEGQLKHLEHQEGQLEVPEEQMGQLKYLEQQEGQLKHLDQQEKQPELPEQQ-MGQL 313
Query: 262 AHSPQ--GYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPE 319
H Q G E+ +++++ ++ E G+ E + H+E + P
Sbjct: 314 KHLEQQEGQPKHLEQQEGQLEQLEEQEGQLKHLEQQEGQLEHLE-----HQEGQLGLPE- 367
Query: 320 PIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQR 379
QQ ++ ++ E+ Q + +H LEEEE GQ +HL ++ +E + + ++R
Sbjct: 368 --QQVLQLKQLEKQQGQPKH---LEEEE----GQLKHLVQQEGQLKHLVQQEGQLEQQER 418
Query: 380 EAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRL 439
+ +L + + + + +K + QLE V Q + +Q + E QQ
Sbjct: 419 QVEHLEQQVGQLKHLEEQEGQLKHLEQQQGQLEVPEQQVGQPKNLEQEEKQLELPEQQEG 478
Query: 440 QGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGI 499
Q L +QE Q + +++ + E +E +H EQ Q + ++ E Q
Sbjct: 479 QVKHLEKQEAQLELPEQQVGQPKHLEQQEKHLEHPEQQDGQLKHLEQQEGQLKDLEQQKG 538
Query: 500 QGEEGAY 506
Q E+ +
Sbjct: 539 QLEQPVF 545
Score = 73.6 bits (179), Expect = 6e-13
Identities = 94/400 (23%), Positives = 177/400 (44%), Gaps = 53/400 (13%)
Query: 296 PGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAE 355
P ++ PT Q P + EV ++ E+H K L E+E EQ
Sbjct: 26 PVNTHQEQMKQPTPLPPPCQKVPVELPVEVPSKQEEKHMTAV---KGLPEQECEQ----- 77
Query: 356 HLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQR 415
++ +P +E ++ EQHE+ + A E + E + + K Q E++L Q+
Sbjct: 78 ---QQKEPQEQELQQQHWEQHEEYQKAENPEQQLKQEKTQRDQQLNK-QLEEEKKLLDQQ 133
Query: 416 LAVQQVEEAQQLREHQEALHQ--QRLQGHL--LRQQEQQ-----QQQVAREMALQRQAEL 466
L + V+ +QL +E L + ++ +GHL L QQE Q QQ+ E+ Q++ +L
Sbjct: 134 LDQELVKRDEQLGMKKEQLLELPEQQEGHLKHLEQQEGQLKHPEQQEGQLELPEQQEGQL 193
Query: 467 E-----EGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPG 521
E EG+ + EQ Q ++ E Q EG E Q + + E
Sbjct: 194 ELPEQQEGQLELPEQQEGQLELPEQQEGQLELPEQQ-----EGQLELPQQQEGQLE---- 244
Query: 522 NRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQK 581
+++G E + E +E + +G+ E E + + + L + + K
Sbjct: 245 --LSEQQEGQLELSEQQEGQLKHLE--------HQEGQLEVPEEQMGQLKYLEQQEGQLK 294
Query: 582 QSNQKQENTEV-EEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEH-NAEE 639
+Q+++ E+ E+ + + +QQE Q + ++E Q + EE++ +L+H +E
Sbjct: 295 HLDQQEKQPELPEQQMGQLKHLEQQEG----QPKHLEQQEGQLEQLEEQEGQLKHLEQQE 350
Query: 640 TYGENDENTDDKNNDGEEQ--EVRDDNRPKGREEHYEEEE 677
E+ E+ + + E+Q +++ + +G+ +H EEEE
Sbjct: 351 GQLEHLEHQEGQLGLPEQQVLQLKQLEKQQGQPKHLEEEE 390
Score = 73.2 bits (178), Expect = 8e-13
Identities = 109/451 (24%), Positives = 191/451 (42%), Gaps = 78/451 (17%)
Query: 295 VPGRAEDTKLYAPT---HKEAEFQAPPEPIQQEVERR---EPEEHQVEEEHRKALEEEEM 348
VP + E+ + A +E E Q EP +QE++++ + EE+Q E + L++E+
Sbjct: 55 VPSKQEEKHMTAVKGLPEQECE-QQQKEPQEQELQQQHWEQHEEYQKAENPEQQLKQEKT 113
Query: 349 EQVGQA-EHLEEEHDPSPEEQDREWKEQHEQ--REAANLLEGHARAEVYPSAKPMIKFQS 405
++ Q + LEEE ++ D+E ++ EQ + LLE + E + + Q
Sbjct: 114 QRDQQLNKQLEEEKKLLDQQLDQELVKRDEQLGMKKEQLLELPEQQEGHLKHLEQQEGQL 173
Query: 406 PYEEQLEQQRLAVQQVEEAQQLREHQEAL----HQQRLQGHLLRQQEQQ-----QQQVAR 456
+ EQ E Q +Q E +L E QE QQ Q L QQE Q QQ+
Sbjct: 174 KHPEQQEGQLELPEQQEGQLELPEQQEGQLELPEQQEGQLELPEQQEGQLELPEQQEGQL 233
Query: 457 EMALQRQAELEEGRPQH------QEQLRQQAHYDAMDNDIVQGAEDQG----IQGEEGAY 506
E+ Q++ +LE Q ++Q Q H + + + E G ++ +EG
Sbjct: 234 ELPQQQEGQLELSEQQEGQLELSEQQEGQLKHLEHQEGQLEVPEEQMGQLKYLEQQEGQL 293
Query: 507 ERDNQ----------------HQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINP 550
+ +Q H ++ EG P +H +++G E E E +E
Sbjct: 294 KHLDQQEKQPELPEQQMGQLKHLEQQEGQP--KHLEQQEGQLEQLEEQEGQLKHLE---- 347
Query: 551 ADDPNNQGEDEFEEAE-QVREENLPDENEEQKQSNQKQEN--TEVEEHLVMAGNPDQQED 607
Q E + E E Q + LP++ Q + +KQ+ +EE + QQE
Sbjct: 348 ------QQEGQLEHLEHQEGQLGLPEQQVLQLKQLEKQQGQPKHLEEEEGQLKHLVQQEG 401
Query: 608 NVDEQYQEEAEEEVQEDLT-------------EEKKRELEHNAEETYGE----NDENTDD 650
+ Q+E + E QE EE++ +L+H E+ G+ +
Sbjct: 402 QLKHLVQQEGQLEQQERQVEHLEQQVGQLKHLEEQEGQLKH-LEQQQGQLEVPEQQVGQP 460
Query: 651 KNNDGEEQEVRDDNRPKGREEHYEEEEEEEE 681
KN + EE+++ + +G+ +H E++E + E
Sbjct: 461 KNLEQEEKQLELPEQQEGQVKHLEKQEAQLE 491
Score = 48.1 bits (113), Expect = 3e-05
Identities = 41/183 (22%), Positives = 84/183 (45%), Gaps = 19/183 (10%)
Query: 520 PGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEE 579
P N H+ + + P P + + VE P + P+ Q E + + E+ + +E
Sbjct: 26 PVNTHQEQMKQPTPLPPPCQ--KVPVE--LPVEVPSKQEEKHMTAVKGLPEQECEQQQKE 81
Query: 580 QKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEE 639
++ +Q++ E E A NP+QQ +Q + + ++++ + L EEKK L+ ++
Sbjct: 82 PQEQELQQQHWEQHEEYQKAENPEQQL----KQEKTQRDQQLNKQLEEEKKL-LDQQLDQ 136
Query: 640 TYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEE------EEEEDGAAVAEKSHRR 693
+ DE K +EQ + + +G +H E++E E++E + E+ +
Sbjct: 137 ELVKRDEQLGMK----KEQLLELPEQQEGHLKHLEQQEGQLKHPEQQEGQLELPEQQEGQ 192
Query: 694 AEM 696
E+
Sbjct: 193 LEL 195
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 88.6 bits (218), Expect = 2e-17
Identities = 88/384 (22%), Positives = 177/384 (46%), Gaps = 61/384 (15%)
Query: 259 TQVAHSPQGYNTAREKPT-------REVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKE 311
+Q PQ N++ ++P E+ E +R + + + E + P H++
Sbjct: 51 SQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPGQRELQLQQLEQQPEPQQ--QPQHEQ 108
Query: 312 AEFQAPPEPIQQEVERREPEE-HQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDR 370
+ P +QQ+ ++ ++ Q+++E +++ +E++ Q H +++ P ++ +
Sbjct: 109 LQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQ 168
Query: 371 EWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREH 430
++Q EQ + Q+ ++ L+QQ QQV+E Q L++
Sbjct: 169 RLQQQQEQLQTQ---------------------QAQEQQVLQQQEQLQQQVQEQQLLQQQ 207
Query: 431 QEALHQQ-------RLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQE-QLRQQAH 482
QE L QQ +LQ +QQ++Q QQ + + LQ+Q +L++ Q Q+ QL+QQ
Sbjct: 208 QEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQ-- 265
Query: 483 YDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADR 542
++ Q + +Q +E + Q Q + + + ++ P +PE E
Sbjct: 266 --LLEQQQAQLQQQLLLQQQE---QLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEE--- 317
Query: 543 AAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNP 602
E++ P + G + +E EQ R+E L + E ++Q Q+Q +++E L
Sbjct: 318 ---EEVELELMPVDLGSE--QELEQQRQE-LERQQELERQQEQRQLQLKLQEEL------ 365
Query: 603 DQQEDNVDEQYQEEAEEEVQEDLT 626
Q E +++Q Q+ ++EVQ +LT
Sbjct: 366 QQLEQQLEQQQQQLEQQEVQLELT 389
Score = 83.6 bits (205), Expect = 6e-16
Identities = 89/382 (23%), Positives = 172/382 (45%), Gaps = 50/382 (13%)
Query: 297 GRAEDTKLYAPTHKEAEFQAPP--EPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQA 354
G +E + P + + Q P P+ E Q E + ++ ++ E +Q Q
Sbjct: 47 GGSESQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPGQRELQLQQLEQQPEPQQQPQH 106
Query: 355 EHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQ 414
E L++ P P + ++ +Q Q++ + L + ++ + KP ++ +QQ
Sbjct: 107 EQLQQ---PQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMH------QQQ 157
Query: 415 RLAVQQVEEAQQLREHQEALHQQRLQGH-LLRQQEQQQQQVAREMALQRQAELEEGRP-- 471
+L QQV+E Q+L++ QE L Q+ Q +L+QQEQ QQQV + LQ+Q E + +
Sbjct: 158 QLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLL 217
Query: 472 QHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGP 531
Q QEQL+QQ + +Q + + ++G ++ Q +A+ + + Q
Sbjct: 218 QQQEQLQQQQFQQQQEQ--LQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQ 275
Query: 532 READPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQ---- 587
++ + + E+ +Q +++ L + +EQ Q Q Q
Sbjct: 276 QQLLLQQQ-----------------------EQLQQQQQQQLLQQQQEQLQQQQLQPPPL 312
Query: 588 ---ENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGEN 644
E EVE L+ +QE EQ ++E E + QE ++++R+L+ +E +
Sbjct: 313 EPEEEEEVELELMPVDLGSEQEL---EQQRQELERQ-QELERQQEQRQLQLKLQEELQQL 368
Query: 645 DENTDDKNNDGEEQEVRDDNRP 666
++ + + E+QEV+ + P
Sbjct: 369 EQQLEQQQQQLEQQEVQLELTP 390
Score = 68.2 bits (165), Expect = 3e-11
Identities = 90/384 (23%), Positives = 161/384 (41%), Gaps = 74/384 (19%)
Query: 124 QHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENR 183
QHE+L++ LE + + Q D +Q+ QLQQEK Q + +E
Sbjct: 105 QHEQLQQPQPHLELQQQPQ--------QDGQQQLSQLQQEKHQSVHH--------QELKP 148
Query: 184 QLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNR 243
+L+ HQ Q Q V++Q + L + EQL QTQ A+ +Q+
Sbjct: 149 ELQLMHQQQQLQPQQVQEQQR-LQQQQEQL--------------QTQQAQEQQV------ 187
Query: 244 IPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTK 303
L++ + +QQ ++ ++ QE + + Q E + +
Sbjct: 188 ---LQQQEQLQQQ-------------VQEQQLLQQQQEQLQQQQLLQQQEQL-----QQQ 226
Query: 304 LYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDP 363
+ ++ + Q +QQ+ + ++ Q + + ++ L E++ Q+ Q L+++
Sbjct: 227 QFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQL 286
Query: 364 SPEEQDREWKEQHEQREAANL----LEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQ 419
++Q + ++Q EQ + L LE EV P+ E++LEQQR Q
Sbjct: 287 QQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPV---DLGSEQELEQQR---Q 340
Query: 420 QVEEAQQLREHQEALH-----QQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQ 474
++E Q+L QE Q+ LQ L +Q EQQQQQ+ ++ +E G Q +
Sbjct: 341 ELERQQELERQQEQRQLQLKLQEELQ-QLEQQLEQQQQQLEQQEVQLELTPVELGAQQQE 399
Query: 475 EQLRQQAHYDAMDNDIVQGAEDQG 498
QL + ++V A G
Sbjct: 400 VQLELTPVQPELQLELVPAAGGGG 423
Score = 67.0 bits (162), Expect = 6e-11
Identities = 67/316 (21%), Positives = 143/316 (45%), Gaps = 57/316 (18%)
Query: 230 QVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSP-QGYNTAREKPTREVQEVSRNNDV 288
Q +++QL+ + ++P QQ ++Q+ Q + KP ++
Sbjct: 102 QQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMH------- 154
Query: 289 WQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEM 348
Q + P + ++ + ++ + Q E QQ ++++E + QV+E+ ++E++
Sbjct: 155 -QQQQLQPQQVQEQQRLQQQQEQLQTQQAQE--QQVLQQQEQLQQQVQEQQLLQQQQEQL 211
Query: 349 EQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLE--GHARAEVYPSAKPMIKFQSP 406
+Q + L ++ + ++Q ++ +EQ +Q++ LL+ G + ++ + ++ Q
Sbjct: 212 QQ----QQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLL 267
Query: 407 YEEQLE-QQRLAVQQVEEAQQ------LREHQEALHQQRLQGHLLRQQEQQQQQVA---- 455
++Q + QQ+L +QQ E+ QQ L++ QE L QQ+LQ L +E+++ ++
Sbjct: 268 EQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPV 327
Query: 456 ----------REMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQ------------- 492
+ L+RQ ELE + Q Q QL+ Q ++ + Q
Sbjct: 328 DLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLE 387
Query: 493 ------GAEDQGIQGE 502
GA+ Q +Q E
Sbjct: 388 LTPVELGAQQQEVQLE 403
Score = 60.8 bits (146), Expect = 4e-09
Identities = 66/285 (23%), Positives = 123/285 (43%), Gaps = 26/285 (9%)
Query: 404 QSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQ 463
+ P E QR AV A ++ E Q+ LQ L QQ + QQQ E Q Q
Sbjct: 55 EEPQERNSSPQRPAVSAPVGASEIAEETRP-GQRELQLQQLEQQPEPQQQPQHEQLQQPQ 113
Query: 464 AELE-EGRPQH--QEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDP 520
LE + +PQ Q+QL Q +Q + Q + +E E HQ +
Sbjct: 114 PHLELQQQPQQDGQQQLSQ-----------LQQEKHQSVHHQELKPELQLMHQQQQLQPQ 162
Query: 521 GNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEF---EEAEQVREENLPDEN 577
+ + R Q +E +A V + + Q +++ ++ EQ++++ L +
Sbjct: 163 QVQEQQRLQQQQEQLQTQQAQEQQV--LQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQ 220
Query: 578 EE--QKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEH 635
E+ Q+Q Q+QE + ++ L++ QQ+ + +Q ++ + ++Q+ L E+++ +L+
Sbjct: 221 EQLQQQQFQQQQEQLQQQQQLLLL----QQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQ 276
Query: 636 NAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEE 680
E + + ++QE + + EEEEE E
Sbjct: 277 QLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVE 321
Score = 54.7 bits (130), Expect = 3e-07
Identities = 73/346 (21%), Positives = 153/346 (44%), Gaps = 41/346 (11%)
Query: 72 EKSLQKERLEHKKAKEDFLVYKLEAQ-----ETLNKGRQDSNSRYSAL------NVQHQM 120
++ LQ ++LE + + ++ Q E + +QD + S L +V HQ
Sbjct: 86 QRELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQE 145
Query: 121 LKSQ----HEELKKQHSDLEEEHR-KQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETV 175
LK + H++ + Q ++E+ R +Q ++ +T +Q+ LQ Q++ +Q++ + ++ +
Sbjct: 146 LKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQE-QQLL 204
Query: 176 YNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYK 235
+E+ +Q + Q Q Q +QQ + L + +QL++ + + Q Q A+ +
Sbjct: 205 QQQQEQLQQQQLLQQQEQLQQQQFQQQQEQ-LQQQQQLLLLQQQGQLQQQLLQQQQAQLQ 263
Query: 236 QLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAV 295
Q L + A+ Q + Q +++ ++ QE + + Q
Sbjct: 264 Q---------QLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQL-QPPPLE 313
Query: 296 PGRAEDTKL-YAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQA 354
P E+ +L P +E + E +QE+ER++ E Q E+ + +EE++Q+ Q
Sbjct: 314 PEEEEEVELELMPVDLGSEQEL--EQQRQELERQQELERQQEQRQLQLKLQEELQQLEQ- 370
Query: 355 EHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPM 400
E+Q ++ ++Q Q E + G + EV P+
Sbjct: 371 ---------QLEQQQQQLEQQEVQLELTPVELGAQQQEVQLELTPV 407
Score = 39.3 bits (90), Expect = 0.012
Identities = 36/170 (21%), Positives = 79/170 (46%), Gaps = 10/170 (5%)
Query: 35 ELQTQLRKAEAVALKYQQ-HQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYK 93
+LQ QL + + L+ Q Q+ Q Q++ + + +L++ Q++ L+ ++ +
Sbjct: 249 QLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQ------- 301
Query: 94 LEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDH 153
L+ Q+ + L + L S+ +EL++Q +LE + + + R
Sbjct: 302 LQQQQLQPPPLEPEEEEEVELELMPVDLGSE-QELEQQRQELERQQELERQQEQRQLQLK 360
Query: 154 KQKYLQ-LQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQ 202
Q+ LQ L+Q+ EQ+ +L++ L +L Q++ +L V+ +
Sbjct: 361 LQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLELTPVQPE 410
Score = 32.3 bits (72), Expect = 1.5
Identities = 33/170 (19%), Positives = 66/170 (38%), Gaps = 23/170 (13%)
Query: 517 EGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDE 576
+G PG G E+ E E PA + EE + E +
Sbjct: 34 DGGPGPDTLSGGSGGSESQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPGQRELQLQQ 93
Query: 577 NEEQKQSNQKQENTEVEE---HLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKREL 633
E+Q + Q+ ++ ++++ HL + P Q Q Q+E + V +E K EL
Sbjct: 94 LEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHH---QELKPEL 150
Query: 634 E--HNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEE 681
+ H ++ + Q+V++ R + ++E + ++ +E+
Sbjct: 151 QLMHQQQQL---------------QPQQVQEQQRLQQQQEQLQTQQAQEQ 185
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 88.6 bits (218), Expect = 2e-17
Identities = 146/656 (22%), Positives = 268/656 (40%), Gaps = 90/656 (13%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKL 94
+L+ QL E +AL+ +++ + Q +++ E + E Q+ L H + +L
Sbjct: 1547 DLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRET--QRVALTHLTLDLEERSQEL 1604
Query: 95 EAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHK 154
+AQ + + S V + L+ + +E+K Q +EE R Q E ++
Sbjct: 1605 QAQSS------QIHDLESHSTVLARELQERDQEVKSQREQIEELQR-QKEHLTQDLERRD 1657
Query: 155 QKYLQLQQEKEQELSK------------LKETVYNLREENRQLRKAHQDIHTQLQDVKQQ 202
Q+ L LQ+E+ Q L L++ +LRE R+L Q + + ++ K
Sbjct: 1658 QE-LMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716
Query: 203 HKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTL-NRIPSL-RKPDPAE---QQN 257
K E + + L D + + Q + E ++LKD L ++ L RK Q
Sbjct: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQR 1776
Query: 258 VTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAP 317
++ Q ARE+ E++E S + + + A+ R ++
Sbjct: 1777 EQEIVVLQQQLQEAREQ--GELKEQSLQSQLDEAQRALAQRDQEL--------------- 1819
Query: 318 PEPIQQEVERREPEEHQVEEEH---RKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKE 374
E +QQE ++ + +E +V+E+ + ALE+ M + L ++H + E
Sbjct: 1820 -EALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGEL-QDHKEQARRLEEELAV 1877
Query: 375 QHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEA-----QQLRE 429
+ + +A + G RAE K ++ Q EQ ++ + + ++++ L+E
Sbjct: 1878 EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKE 1937
Query: 430 HQEALHQQRLQGHLLRQQEQ--QQQQVAREMALQRQAELEEGRPQH---QEQLRQ----- 479
+ L R + R QE+ + + A + AL + +G+ QH Q +L +
Sbjct: 1938 RDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAS 1997
Query: 480 ----QAHYDAMDNDIVQGAE-----DQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQG 530
QA DA Q E + IQ ++ Y+ D Q +A E R Q
Sbjct: 1998 TATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQ--RDEELRHQQ 2055
Query: 531 PREADPESEADRAAVEDINPADDPNNQGEDEFEEA-----EQVREENLPDENEEQK---- 581
RE E + E N + N G++ EE + VRE L +EQ+
Sbjct: 2056 EREQLLEKSLAQRVQE--NMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILEL 2113
Query: 582 QSNQKQENTEVEEHLVMAGNPDQQE---DNVDEQYQEEAEEEVQEDLTEEKKRELE 634
+ Q++ N E H ++Q D+++ + Q E E +Q L + + RE+E
Sbjct: 2114 RETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQREL-ERLQAALRQTEAREIE 2168
Score = 79.3 bits (194), Expect = 1e-14
Identities = 126/664 (18%), Positives = 279/664 (42%), Gaps = 80/664 (12%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYK- 93
+LQ QL + + K++ Q SL ++L ++E + L+ L++ L+ +A+ + + +
Sbjct: 1289 DLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQA 1348
Query: 94 ----LEAQ-ETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSR 148
L AQ E L ++ ++ SA + + L++ LK ++ ++E E
Sbjct: 1349 AKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESE---------- 1398
Query: 149 TFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHT---QLQDVKQQHKN 205
+++ LQ++ E ++++ K NL + L + +++ T Q+Q++++Q +
Sbjct: 1399 -----RERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREM 1453
Query: 206 LLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIP-SLRKPDPAEQQNVTQVAHS 264
+ E L + L+ + Q Q+ E ++ + L +P ++++ + Q+
Sbjct: 1454 QKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIREL 1513
Query: 265 PQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQE 324
+ T R ++ E+ + + Q E+ G+ +D K T E + E
Sbjct: 1514 EKDRETQRNVLEHQLLELEKKD---QMIESQRGQVQDLKKQLVTL---------ECLALE 1561
Query: 325 VERREPEEHQVEEEHRKALEEEEMEQVGQA---EHLEEEHDPSPEEQDREWKEQHEQREA 381
+E E H E +K ++E E ++ Q HL + + +E + + H+
Sbjct: 1562 LE----ENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHD---- 1613
Query: 382 ANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQG 441
LE H+ + + +++++ QR +Q+EE Q+ +EH ++R Q
Sbjct: 1614 ---LESHSTV--------LARELQERDQEVKSQR---EQIEELQRQKEHLTQDLERRDQE 1659
Query: 442 HLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQG 501
+L ++++ QV + ++ LEE Q + LR++ ++Q ++G +G
Sbjct: 1660 LML---QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEG-KG 1715
Query: 502 EEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNN----Q 557
A +H D E +++ E + ++ ++ + Q
Sbjct: 1716 PSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQ 1775
Query: 558 GEDEF----EEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQY 613
E E ++ ++ RE+ E Q Q ++ Q + + A +QQ+ E+
Sbjct: 1776 REQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEER 1835
Query: 614 QEEAEEEVQEDLTE------EKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPK 667
+E + +Q L + E+ EL+ + E+ +E + +EV D R +
Sbjct: 1836 VKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAE 1895
Query: 668 GREE 671
RE+
Sbjct: 1896 SREQ 1899
Score = 64.3 bits (155), Expect = 4e-10
Identities = 157/721 (21%), Positives = 284/721 (39%), Gaps = 120/721 (16%)
Query: 30 AMLYYELQTQLRKAEAVALKYQQ-HQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKED 88
A L L++ + EA+A + Q +Q AQL +Y + S+ + R E +
Sbjct: 1150 AQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDS 1209
Query: 89 F-LVYKLE-----AQETLNKG----RQDSNSRYSALNVQHQ----------MLKSQHEEL 128
V+ LE A+ +G + + SAL+ HQ +L+ Q ++L
Sbjct: 1210 APSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKL 1269
Query: 129 KKQHSDLEEEHRK---QGEDFSRTFN---DHKQKYLQLQQEKEQELSKLKETVYNLREEN 182
+++ +D E E + + +D R + + K K+ Q E EL +L ET+ +L+
Sbjct: 1270 EERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQS-- 1327
Query: 183 RQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLN 242
+LR+A Q + + + + L + E L +E ++A+ A+ Q + L++ L
Sbjct: 1328 -RLRRA----ELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLR 1382
Query: 243 RIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQE---------VSRNNDVWQNHE 293
S K E ++ + A + Q + + +QE R +V E
Sbjct: 1383 TARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEV----E 1438
Query: 294 AVPGRAEDTKLYAPTHKEA-------------EFQAPPEPIQQEVERREPEEH------- 333
+ G+ ++ + K A E E IQ+ + R EH
Sbjct: 1439 TLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQE 1498
Query: 334 -----QVEEEHRKALEEEEMEQVGQAEH--LE-EEHDPSPEEQDREWKEQHEQRE----- 380
V+ E + LE++ Q EH LE E+ D E Q + ++ +Q
Sbjct: 1499 REQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECL 1558
Query: 381 AANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQ 440
A L E H + E K E Q E QR+A+ + L E + L Q Q
Sbjct: 1559 ALELEENHHKMECQQ------KLIKELEGQRETQRVALTHL--TLDLEERSQELQAQSSQ 1610
Query: 441 GHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYD----------AMDNDI 490
H L E +ARE+ +R E++ R Q +E RQ+ H + +
Sbjct: 1611 IHDL---ESHSTVLARELQ-ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKER 1666
Query: 491 VQGAEDQGIQGE---EGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVED 547
+Q EDQ + E E+ E + + + ++ E S+A R ++E
Sbjct: 1667 IQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEH 1726
Query: 548 IN-PADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQE 606
+ D + E + E +++E L D+ E+Q Q + +V E ++ +Q+
Sbjct: 1727 MKLILRDKEKEVECQQEHIHELQE--LKDQLEQQLQGLHR----KVGETSLLLSQREQEI 1780
Query: 607 DNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDE-----NTDDKNNDGEEQEVR 661
+ +Q QE E Q +L E+ + A+ + D+ + + G+E+ V+
Sbjct: 1781 VVLQQQLQEARE---QGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVK 1837
Query: 662 D 662
+
Sbjct: 1838 E 1838
Score = 63.5 bits (153), Expect = 6e-10
Identities = 130/626 (20%), Positives = 264/626 (42%), Gaps = 89/626 (14%)
Query: 36 LQTQLRKAEAVALKY-QQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKL 94
LQTQL++A+ + +QH++ L+A + E S SL +++++ +K ED L
Sbjct: 969 LQTQLQEAQRELKEAARQHRDDLAA----LQEESS----SLLQDKMDLQKQVED-----L 1015
Query: 95 EAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHK 154
++Q QD + R VQ ++ ++Q +++ +++E ++ + + + +
Sbjct: 1016 KSQLVA----QDDSQRLVEQEVQEKLRETQ------EYNRIQKELEREKASLTLSLMEKE 1065
Query: 155 QKYLQLQQE---KEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHE 211
Q+ L LQ+ ++QELS L++ + + E ++L + + Q+VK++ + L++
Sbjct: 1066 QRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLR---QEVKEKEADFLAQEA 1122
Query: 212 QLVVTLE----DHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQG 267
QL+ LE + A+ Q A+ QL+ L S + AEQQ
Sbjct: 1123 QLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQ----------- 1171
Query: 268 YNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVER 327
P + Q ++ ++ + G +++ P AP V
Sbjct: 1172 -------PGNQAQAQAQLASLYSALQQALGSVCESR---PELSGGGDSAP------SVWG 1215
Query: 328 REPEEHQVEEEHRKA--LEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLL 385
EP+++ ++ L E V A H + D +Q R+ Q+ L
Sbjct: 1216 LEPDQNGARSLFKRGPLLTALSAEAVASALH-KLHQDLWKTQQTRDVLRDQVQKLEERLT 1274
Query: 386 EGHA-RAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVE-EAQQLREHQEALHQQRLQGHL 443
+ A +++V+ + + + S +E+ + +E E +L E +L + + L
Sbjct: 1275 DTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAEL 1334
Query: 444 LRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEE 503
R + Q ++++ + A++E + E Q + ++ D+ ++ EE
Sbjct: 1335 QRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEE 1394
Query: 504 GAYERDN----QHQDEAEGDPGNRHEPR----EQGPREADPESEADRAAVEDINPADDPN 555
ER+ Q Q E + G + Q E + E E R ++++
Sbjct: 1395 VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQEL------- 1447
Query: 556 NQGEDEFEEAE-QVREENLPDENEE----QKQSNQKQENTEVEEHLVMAGNPDQQEDNVD 610
+ + E ++A ++ +L N+E Q+Q + ++ V EHL MA +Q+ V
Sbjct: 1448 -EKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQ 1506
Query: 611 -EQYQE-EAEEEVQEDLTEEKKRELE 634
EQ +E E + E Q ++ E + ELE
Sbjct: 1507 REQIRELEKDRETQRNVLEHQLLELE 1532
Score = 58.9 bits (141), Expect = 2e-08
Identities = 132/723 (18%), Positives = 275/723 (38%), Gaps = 79/723 (10%)
Query: 32 LYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLV 91
L + Q Q E + ++ E L + EH + L ++ Q+E+L ++ +D
Sbjct: 291 LLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQ 350
Query: 92 YKLEAQETLNKGRQDSNSR----------------------YSALNVQHQMLKSQHEELK 129
+E + + +G NS S L + Q ++ ++L
Sbjct: 351 VMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLA 410
Query: 130 --KQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRK 187
++ +L ++ Q E+ + QK + + L+ V +L +E L+K
Sbjct: 411 GCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQK 470
Query: 188 AHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQ----VAEYKQLK----- 238
A +++ QL+ ++Q+ L + +L + + + Q + V E ++L+
Sbjct: 471 AREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMG 530
Query: 239 ------DTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNH 292
++L+ + +LR+ + + A + + + E+S + + +
Sbjct: 531 LEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKT- 589
Query: 293 EAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVG 352
E RA KL A A + Q++ + E E V A + QV
Sbjct: 590 EVADLRAAAVKLSALNEALA---LDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVD 646
Query: 353 QAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLE 412
AE E+ + E++ + Q ++ E A +A++ + + Q E
Sbjct: 647 LAE--AEKRREALWEKNTHLEAQLQKAEEAG---AELQADLRDIQEEKEEIQKKLSESRH 701
Query: 413 QQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQ-QQQQVAREMALQ-----RQ--A 464
QQ A Q+E+ HQEA Q+ + ++++E +++ A E+ LQ RQ A
Sbjct: 702 QQEAATTQLEQL-----HQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLA 756
Query: 465 ELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQ-------GIQGEEGAYERDNQHQDEAE 517
E +G +E L N +++ + Q Q +E + E +
Sbjct: 757 EQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELD 816
Query: 518 GDPGNRHEPREQGPREADPESEADRAAVEDINPADDPN-NQGEDEFEEAEQVREENLP-- 574
+ + R+ R+ + + A+E A + NQ +++E+ ++ L
Sbjct: 817 TERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKA 876
Query: 575 ----DENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEE---VQEDLTE 627
+ + + + K++ TE+E Q ++ Q Q E E+E + E L +
Sbjct: 877 LESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQ 936
Query: 628 EKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVA 687
+K EL +++ + K + E + + + E E + +D AA+
Sbjct: 937 TQK-ELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQ 995
Query: 688 EKS 690
E+S
Sbjct: 996 EES 998
Score = 57.4 bits (137), Expect = 4e-08
Identities = 98/473 (20%), Positives = 203/473 (42%), Gaps = 45/473 (9%)
Query: 29 GAMLYYELQTQLRKAEAVALKYQQ---HQESLSAQLQVVYEHRSRLEKSL-----QKERL 80
GA L +L+ + E + K + QE+ + QL+ +++ R E+ L +KE L
Sbjct: 675 GAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEAL 734
Query: 81 EHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHR 140
+KA L +L+A E + RQD + L+ ++L+S E ++Q+S +E +
Sbjct: 735 VREKAA---LEVRLQAVE---RDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVT-K 787
Query: 141 KQGEDFSRTFNDHKQ------KYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHT 194
Q E +T K+ + L+L+ + E+ ++ + RQL +A Q+ T
Sbjct: 788 GQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDA-----AARQLAQAEQEGKT 842
Query: 195 QLQDVKQQHKNLLSE-HEQLVVTLEDHKSALAAAQTQVAEYK-----QLKDTLNRIPSLR 248
L+ K H+ +++ E+ H+ LA A + K +LK+ + +++
Sbjct: 843 ALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902
Query: 249 KPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPT 308
E++ + A T +E+ + + ++ + + +D K+
Sbjct: 903 A-QREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL- 960
Query: 309 HKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQ 368
KE E + QE +R E + + AL+EE + L+++ D + +
Sbjct: 961 -KEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEES------SSLLQDKMDLQKQVE 1013
Query: 369 DREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLR 428
D + + Q ++ L+E + E + + Q E + L++ + E+ +
Sbjct: 1014 DLK-SQLVAQDDSQRLVEQEVQ-EKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVL 1071
Query: 429 EHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQA 481
+ +++ QQ L LRQ Q+ Q +E++ Q + +E + + + L Q+A
Sbjct: 1072 QEADSIRQQELSA--LRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEA 1122
Score = 50.4 bits (119), Expect = 5e-06
Identities = 110/555 (19%), Positives = 205/555 (36%), Gaps = 77/555 (13%)
Query: 90 LVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRT 149
L+ L + L K + + L Q + K++ ++ + S L + +KQ ED+
Sbjct: 246 LLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDY--- 302
Query: 150 FNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSE 209
E+ + L+ETV L + +L + + Q+ K + ++ +
Sbjct: 303 ---------------EKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKD 347
Query: 210 HEQLVVTLED-------HKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVA 262
Q++V D H+++L + +++ +D + +R +Q V +
Sbjct: 348 ITQVMVEEGDNIAQGSGHENSLELDSSIFSQF-DYQDADKALTLVRSVLTRRRQAVQDLR 406
Query: 263 HSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQ 322
G A V + + +D W+ G+A +L T + +Q
Sbjct: 407 QQLAGCQEA-------VNLLQQQHDQWEEE----GKALRQRLQKLTGERDTLAGQTVDLQ 455
Query: 323 QEVERREPEE---HQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQR 379
EV+ E + EE R+ LE E E A L + + D ++ EQ+
Sbjct: 456 GEVDSLSKERELLQKAREELRQQLEVLEQE----AWRLRRVNVELQLQGDSAQGQKEEQQ 511
Query: 380 EAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRL 439
E +L ++ + +E L L +Q E +L +EAL L
Sbjct: 512 EELHL---------------AVRERERLQEML--MGLEAKQSESLSELITLREALESSHL 554
Query: 440 QGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGI 499
+G LLR QEQ + A A Q AEL + ++ D+ A
Sbjct: 555 EGELLR-QEQTEVTAALARAEQSIAELSSSENTLKTEVA----------DLRAAAVKLSA 603
Query: 500 QGEEGAYERDNQHQDEAEGDPGNRHE-PREQGPREADPESEADRAAVEDINPA-DDPNNQ 557
E A ++ +Q + + N+ R + +A + D A E A + N
Sbjct: 604 LNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTH 663
Query: 558 GEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEA 617
E + ++AE+ E D + Q++ + Q+ H A ++ + + + QEE
Sbjct: 664 LEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEV 723
Query: 618 ---EEEVQEDLTEEK 629
+ +E L EK
Sbjct: 724 LARAVQEKEALVREK 738
Score = 38.9 bits (89), Expect = 0.016
Identities = 98/479 (20%), Positives = 178/479 (37%), Gaps = 79/479 (16%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLS---AQLQVVYEH---RSRLEKSLQKERLEHKKAKED 88
E Q+ + EA + + QE+L A LQ +H ++ L +SL+ + + +
Sbjct: 1948 ESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDA 2007
Query: 89 FLVYKLEAQETLN--KGR-QDSNSRYSALNVQH--QMLKSQHEELKKQHSDLEEEHRKQG 143
+ + +E L +G QD + RY +VQ Q L + EEL+ Q + +
Sbjct: 2008 CQAHSRQLEEALRIQEGEIQDQDLRYQE-DVQQLQQALAQRDEELRHQQEREQLLEKSLA 2066
Query: 144 EDFSRTFNDHKQKYLQLQQEKE-----QELSKLKETVYNLREENRQLRKAHQDIHTQLQD 198
+ KQ Q ++E+E Q + +L+ T+ +E +LR+ Q L+
Sbjct: 2067 QRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQ--RNNLEA 2124
Query: 199 VKQQHKNLLSEHEQLVVT---------LEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRK 249
+ HK E + L + LE ++AL + + E+++ L + K
Sbjct: 2125 LPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTK 2184
Query: 250 PDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTH 309
+ Q V + + ++ ++ E++R + + PG +L +
Sbjct: 2185 ASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRA-LEKERLHSPGATSTAELGSRGE 2243
Query: 310 KEAEF------QAPPEP--------------IQQ-----EVERREPEEH---------QV 335
+ + +A P P +QQ E++R + H QV
Sbjct: 2244 QGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQV 2303
Query: 336 EEEHRKALEEEEME--QVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANL--------- 384
E E RK L+ E M Q G E + + SP +QD ++ + + A L
Sbjct: 2304 ERERRK-LKREAMRAAQAGSLE-ISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQA 2361
Query: 385 ---LEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQ 440
LE + + + + + L LAV Q EA L L + Q
Sbjct: 2362 QLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQ 2420
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 87.4 bits (215), Expect = 4e-17
Identities = 150/729 (20%), Positives = 293/729 (40%), Gaps = 123/729 (16%)
Query: 41 RKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETL 100
R+ + + QQH + L A L+ R +L+ + KK +ED L+
Sbjct: 964 RQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLL-------- 1015
Query: 101 NKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGE---DFSRTFNDHKQKY 157
+D NS+ L+ + ++L+ + E Q ++ EE+ + + + T D + +
Sbjct: 1016 ----EDQNSK---LSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDR- 1067
Query: 158 LQLQQEKEQELSKLKETV----YNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHE-- 211
L+ +++ QEL KLK + L+E+ + ++ +++ QL +++ + L+ E
Sbjct: 1068 LRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDE 1127
Query: 212 -----QLVVTLEDHKSALAAAQ-----TQVAEYK-----------------QLKDTLNRI 244
QL+ +L + ++ALA AQ +VA K +L+DTL+
Sbjct: 1128 GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDST 1187
Query: 245 PSLRKPDPAEQQNVTQ---------------VAHSPQGYNTAREKPTREVQEVSRNNDVW 289
+ ++ +Q VT+ V Q + A + ++++ R W
Sbjct: 1188 NAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAW 1247
Query: 290 Q------NHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKAL 343
+ E RAE + L + + + E QEV+ R + + E + L
Sbjct: 1248 EKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKL 1307
Query: 344 EEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVY--PSAKPMI 401
+ + E + L E + + + +A LL+ RA++ + M
Sbjct: 1308 QRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAME 1367
Query: 402 KFQSPYEEQLEQQRLAVQQVEEAQQLREHQ--EALHQQRLQGHLLRQQEQQQQQVAR--E 457
+ EQLE++ A ++ Q + Q E +Q + L E+ +++ AR E
Sbjct: 1368 AEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAE 1427
Query: 458 MALQRQAE-------LEEGRPQHQEQLRQQAHYDAMDNDIVQGAE------DQGIQGEEG 504
QR AE LE GR + Q++L +V E DQ + E+
Sbjct: 1428 ALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKA 1487
Query: 505 AYERDNQHQDEAEGDPGNRH----------EPREQGPREADPESEADRAAVEDINPADDP 554
A R + ++ AE + R E ++ E + ++ A RA +E + + D
Sbjct: 1488 AVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDD 1547
Query: 555 NNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQ 614
+ E E A +V EQ ++ + + TE+E+ L A + + + + +
Sbjct: 1548 VGKSVHELERACRV---------AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALK 1598
Query: 615 EEAEEEVQ--EDLTEEKKRELEHNAEETYGENDENTDD--------KNNDGEEQEVRDD- 663
+ E ++Q ++ EE++R+L + E DE K +GE +E++
Sbjct: 1599 TQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQM 1658
Query: 664 -NRPKGREE 671
+ +G+EE
Sbjct: 1659 ASAGQGKEE 1667
Score = 73.6 bits (179), Expect = 6e-13
Identities = 149/696 (21%), Positives = 275/696 (39%), Gaps = 92/696 (13%)
Query: 35 ELQTQL----RKAEAVALKYQQHQESLSAQLQVVYEH---RSRLEKSLQKERLEHKKAKE 87
ELQ Q+ ++AE + + + +E L A L + R++L KSL++ + +A+E
Sbjct: 1091 ELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQE 1150
Query: 88 DFLVYKLEAQETLNKGRQDSNSRYSAL-----------NVQHQMLKSQHEELKKQHSDLE 136
D L + A+ K R+D AL N Q ++ + +E+ + LE
Sbjct: 1151 D-LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLE 1209
Query: 137 EEHRKQGEDFSRTFNDHKQKYLQLQQEKEQEL---SKLKETVYNLREENRQLRKAHQDIH 193
EE R H Q +L ++ EQ ++T L E +LR +
Sbjct: 1210 EETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQ 1269
Query: 194 TQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPA 253
T Q+ +Q+ + L + +++ D + A A A ++ + A
Sbjct: 1270 TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQ-----------------A 1312
Query: 254 EQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHK--- 310
E +NV+ N A K R +E+S Q H+A E+T+
Sbjct: 1313 ELENVSGAL------NEAESKTIRLSKELSSTEA--QLHDAQELLQEETRAKLALGSRVR 1364
Query: 311 --EAEFQAPPEPIQQEVERREPEEHQVEEEHRKALE--EEEMEQVGQAEHLEEEHDPSPE 366
EAE E +++E RE +++ + E + E+ G E EE +
Sbjct: 1365 AMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAR 1424
Query: 367 EQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEE---QLEQQRLAVQQVEE 423
E + + E+ E + LE R + Q ++ LEQQR V +E+
Sbjct: 1425 EAEALTQRLAEKTETVDRLERGRR-----------RLQQELDDATMDLEQQRQLVSTLEK 1473
Query: 424 AQQLREHQEALHQQRLQGHLLRQQEQQQ-------QQVAREMALQRQAELEEGRPQHQEQ 476
Q R+ + L +++ +LR E+++ ++ AR ++L R LEE + +E
Sbjct: 1474 KQ--RKFDQLLAEEKAA--VLRAVEERERAEAEGREREARALSLTRA--LEEEQEAREEL 1527
Query: 477 LRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADP 536
RQ A ++ +D G E ER + ++A D + E A+
Sbjct: 1528 ERQNRALRAELEALLSSKDDVGKSVHE--LERACRVAEQAANDLRAQVTELEDELTAAED 1585
Query: 537 ESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHL 596
V+ + + + QG DE E + + + E ++ +KQ V
Sbjct: 1586 AKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARK 1645
Query: 597 VMAGNPDQQEDNVDE--QYQEEAEEEVQEDLTEEKK--RELEH---NAEETYGENDENTD 649
+ G ++ + + Q +EEA +++++ + K+ RE+E + EE + +N E+
Sbjct: 1646 KLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRES-- 1703
Query: 650 DKNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAA 685
+K G E EV + + +++ D A
Sbjct: 1704 EKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMA 1739
Score = 46.2 bits (108), Expect = 1e-04
Identities = 107/518 (20%), Positives = 203/518 (39%), Gaps = 81/518 (15%)
Query: 34 YELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYK 93
+EL+ R AE A + L +L + + RLE ++Q + +H++ +
Sbjct: 1553 HELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAG 1612
Query: 94 LEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDH 153
E + L K +D+ Q + + ++L+ + +L+ + G
Sbjct: 1613 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAG---------- 1662
Query: 154 KQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQL 213
Q ++E ++L K++ + L E + R + ++I +Q ++ +++ K L +E
Sbjct: 1663 -----QGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE---- 1713
Query: 214 VVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYN-TAR 272
V+ L++ LAA+ + +Q +D + D N+++ A + R
Sbjct: 1714 VLRLQEE---LAASDRARRQAQQDRDEM--------ADEVANGNLSKAAILEEKRQLEGR 1762
Query: 273 EKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEE 332
E E ++N N + L E F A E +Q++ER
Sbjct: 1763 LGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLER----- 1817
Query: 333 HQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAE 392
Q++E + EE+ A + + E + + +EQ EQ +L G
Sbjct: 1818 -QIQELRGRLGEED-----AGARARHKMTIAALESKLAQAEEQLEQETRERILSG----- 1866
Query: 393 VYPSAKPMIKFQSPYEEQLEQQRLAVQQVEE----AQQLREHQEALHQQRLQGHLLRQQE 448
K E++L++ V QVEE A QLR+ E + + Q L RQ E
Sbjct: 1867 ---------KLVRRAEKRLKE---VVLQVEEERRVADQLRDQLEKGNLRVKQ--LKRQLE 1912
Query: 449 QQQQQVAREMALQR--QAELEEGRPQHQEQLRQQAHYDAMDNDIVQG-------AEDQGI 499
+ +++ +R A +R Q ELE+ + R+ + N + +G Q
Sbjct: 1913 EAEEEASRAQAGRRRLQRELEDVTESAESMNRE---VTTLRNRLRRGPLTFTTRTVRQVF 1969
Query: 500 QGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPE 537
+ EEG ++ E PG+ P +G A P+
Sbjct: 1970 RLEEGV----ASDEEAEEAQPGSGPSPEPEGSPPAHPQ 2003
Score = 39.7 bits (91), Expect = 0.010
Identities = 65/279 (23%), Positives = 117/279 (41%), Gaps = 25/279 (8%)
Query: 431 QEALHQQRLQGHLLRQQEQQQQQVAREMA-LQ-RQAELEEGRPQHQEQLRQQAHY--DAM 486
Q+ + Q R Q L++ ++ QQQ ARE+ LQ R A+LEE R + EQLR +A +A
Sbjct: 875 QDEVLQARAQE--LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAE 932
Query: 487 DNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVE 546
+ A Q ++ E ++E + +Q +E + EA+ A +
Sbjct: 933 ETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQ 992
Query: 547 DINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQE 606
+ +FEE + L D+N + + + E+ E + ++E
Sbjct: 993 KLQLEKVTTEAKMKKFEEDLLL----LEDQNSKLSKERKLLEDRLAE----FSSQAAEEE 1044
Query: 607 DNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRP 666
+ V + + E E++ R+ E +E + D ++++ +EQ V R
Sbjct: 1045 EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE-LEKLKRRLDGESSELQEQMVEQQQRA 1103
Query: 667 KGREEHYEEEEEE--------EEDGAAVAE--KSHRRAE 695
+ +EEE E++G A A+ KS R A+
Sbjct: 1104 EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQ 1142
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 87.4 bits (215), Expect = 4e-17
Identities = 150/729 (20%), Positives = 293/729 (40%), Gaps = 123/729 (16%)
Query: 41 RKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETL 100
R+ + + QQH + L A L+ R +L+ + KK +ED L+
Sbjct: 956 RQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLL-------- 1007
Query: 101 NKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGE---DFSRTFNDHKQKY 157
+D NS+ L+ + ++L+ + E Q ++ EE+ + + + T D + +
Sbjct: 1008 ----EDQNSK---LSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDR- 1059
Query: 158 LQLQQEKEQELSKLKETV----YNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHE-- 211
L+ +++ QEL KLK + L+E+ + ++ +++ QL +++ + L+ E
Sbjct: 1060 LRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDE 1119
Query: 212 -----QLVVTLEDHKSALAAAQ-----TQVAEYK-----------------QLKDTLNRI 244
QL+ +L + ++ALA AQ +VA K +L+DTL+
Sbjct: 1120 GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDST 1179
Query: 245 PSLRKPDPAEQQNVTQ---------------VAHSPQGYNTAREKPTREVQEVSRNNDVW 289
+ ++ +Q VT+ V Q + A + ++++ R W
Sbjct: 1180 NAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAW 1239
Query: 290 Q------NHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKAL 343
+ E RAE + L + + + E QEV+ R + + E + L
Sbjct: 1240 EKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKL 1299
Query: 344 EEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVY--PSAKPMI 401
+ + E + L E + + + +A LL+ RA++ + M
Sbjct: 1300 QRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAME 1359
Query: 402 KFQSPYEEQLEQQRLAVQQVEEAQQLREHQ--EALHQQRLQGHLLRQQEQQQQQVAR--E 457
+ EQLE++ A ++ Q + Q E +Q + L E+ +++ AR E
Sbjct: 1360 AEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAE 1419
Query: 458 MALQRQAE-------LEEGRPQHQEQLRQQAHYDAMDNDIVQGAE------DQGIQGEEG 504
QR AE LE GR + Q++L +V E DQ + E+
Sbjct: 1420 ALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKA 1479
Query: 505 AYERDNQHQDEAEGDPGNRH----------EPREQGPREADPESEADRAAVEDINPADDP 554
A R + ++ AE + R E ++ E + ++ A RA +E + + D
Sbjct: 1480 AVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDD 1539
Query: 555 NNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQ 614
+ E E A +V EQ ++ + + TE+E+ L A + + + + +
Sbjct: 1540 VGKSVHELERACRV---------AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALK 1590
Query: 615 EEAEEEVQ--EDLTEEKKRELEHNAEETYGENDENTDD--------KNNDGEEQEVRDD- 663
+ E ++Q ++ EE++R+L + E DE K +GE +E++
Sbjct: 1591 TQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQM 1650
Query: 664 -NRPKGREE 671
+ +G+EE
Sbjct: 1651 ASAGQGKEE 1659
Score = 73.6 bits (179), Expect = 6e-13
Identities = 149/696 (21%), Positives = 275/696 (39%), Gaps = 92/696 (13%)
Query: 35 ELQTQL----RKAEAVALKYQQHQESLSAQLQVVYEH---RSRLEKSLQKERLEHKKAKE 87
ELQ Q+ ++AE + + + +E L A L + R++L KSL++ + +A+E
Sbjct: 1083 ELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQE 1142
Query: 88 DFLVYKLEAQETLNKGRQDSNSRYSAL-----------NVQHQMLKSQHEELKKQHSDLE 136
D L + A+ K R+D AL N Q ++ + +E+ + LE
Sbjct: 1143 D-LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLE 1201
Query: 137 EEHRKQGEDFSRTFNDHKQKYLQLQQEKEQEL---SKLKETVYNLREENRQLRKAHQDIH 193
EE R H Q +L ++ EQ ++T L E +LR +
Sbjct: 1202 EETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQ 1261
Query: 194 TQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPA 253
T Q+ +Q+ + L + +++ D + A A A ++ + A
Sbjct: 1262 TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQ-----------------A 1304
Query: 254 EQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHK--- 310
E +NV+ N A K R +E+S Q H+A E+T+
Sbjct: 1305 ELENVSGAL------NEAESKTIRLSKELSSTEA--QLHDAQELLQEETRAKLALGSRVR 1356
Query: 311 --EAEFQAPPEPIQQEVERREPEEHQVEEEHRKALE--EEEMEQVGQAEHLEEEHDPSPE 366
EAE E +++E RE +++ + E + E+ G E EE +
Sbjct: 1357 AMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAR 1416
Query: 367 EQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEE---QLEQQRLAVQQVEE 423
E + + E+ E + LE R + Q ++ LEQQR V +E+
Sbjct: 1417 EAEALTQRLAEKTETVDRLERGRR-----------RLQQELDDATMDLEQQRQLVSTLEK 1465
Query: 424 AQQLREHQEALHQQRLQGHLLRQQEQQQ-------QQVAREMALQRQAELEEGRPQHQEQ 476
Q R+ + L +++ +LR E+++ ++ AR ++L R LEE + +E
Sbjct: 1466 KQ--RKFDQLLAEEKAA--VLRAVEERERAEAEGREREARALSLTRA--LEEEQEAREEL 1519
Query: 477 LRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADP 536
RQ A ++ +D G E ER + ++A D + E A+
Sbjct: 1520 ERQNRALRAELEALLSSKDDVGKSVHE--LERACRVAEQAANDLRAQVTELEDELTAAED 1577
Query: 537 ESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHL 596
V+ + + + QG DE E + + + E ++ +KQ V
Sbjct: 1578 AKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARK 1637
Query: 597 VMAGNPDQQEDNVDE--QYQEEAEEEVQEDLTEEKK--RELEH---NAEETYGENDENTD 649
+ G ++ + + Q +EEA +++++ + K+ RE+E + EE + +N E+
Sbjct: 1638 KLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRES-- 1695
Query: 650 DKNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAA 685
+K G E EV + + +++ D A
Sbjct: 1696 EKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMA 1731
Score = 46.2 bits (108), Expect = 1e-04
Identities = 107/518 (20%), Positives = 203/518 (39%), Gaps = 81/518 (15%)
Query: 34 YELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYK 93
+EL+ R AE A + L +L + + RLE ++Q + +H++ +
Sbjct: 1545 HELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAG 1604
Query: 94 LEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDH 153
E + L K +D+ Q + + ++L+ + +L+ + G
Sbjct: 1605 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAG---------- 1654
Query: 154 KQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQL 213
Q ++E ++L K++ + L E + R + ++I +Q ++ +++ K L +E
Sbjct: 1655 -----QGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE---- 1705
Query: 214 VVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYN-TAR 272
V+ L++ LAA+ + +Q +D + D N+++ A + R
Sbjct: 1706 VLRLQEE---LAASDRARRQAQQDRDEM--------ADEVANGNLSKAAILEEKRQLEGR 1754
Query: 273 EKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEE 332
E E ++N N + L E F A E +Q++ER
Sbjct: 1755 LGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLER----- 1809
Query: 333 HQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAE 392
Q++E + EE+ A + + E + + +EQ EQ +L G
Sbjct: 1810 -QIQELRGRLGEED-----AGARARHKMTIAALESKLAQAEEQLEQETRERILSG----- 1858
Query: 393 VYPSAKPMIKFQSPYEEQLEQQRLAVQQVEE----AQQLREHQEALHQQRLQGHLLRQQE 448
K E++L++ V QVEE A QLR+ E + + Q L RQ E
Sbjct: 1859 ---------KLVRRAEKRLKE---VVLQVEEERRVADQLRDQLEKGNLRVKQ--LKRQLE 1904
Query: 449 QQQQQVAREMALQR--QAELEEGRPQHQEQLRQQAHYDAMDNDIVQG-------AEDQGI 499
+ +++ +R A +R Q ELE+ + R+ + N + +G Q
Sbjct: 1905 EAEEEASRAQAGRRRLQRELEDVTESAESMNRE---VTTLRNRLRRGPLTFTTRTVRQVF 1961
Query: 500 QGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPE 537
+ EEG ++ E PG+ P +G A P+
Sbjct: 1962 RLEEGV----ASDEEAEEAQPGSGPSPEPEGSPPAHPQ 1995
Score = 39.7 bits (91), Expect = 0.010
Identities = 65/279 (23%), Positives = 117/279 (41%), Gaps = 25/279 (8%)
Query: 431 QEALHQQRLQGHLLRQQEQQQQQVAREMA-LQ-RQAELEEGRPQHQEQLRQQAHY--DAM 486
Q+ + Q R Q L++ ++ QQQ ARE+ LQ R A+LEE R + EQLR +A +A
Sbjct: 867 QDEVLQARAQE--LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAE 924
Query: 487 DNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVE 546
+ A Q ++ E ++E + +Q +E + EA+ A +
Sbjct: 925 ETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQ 984
Query: 547 DINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQE 606
+ +FEE + L D+N + + + E+ E + ++E
Sbjct: 985 KLQLEKVTTEAKMKKFEEDLLL----LEDQNSKLSKERKLLEDRLAE----FSSQAAEEE 1036
Query: 607 DNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRP 666
+ V + + E E++ R+ E +E + D ++++ +EQ V R
Sbjct: 1037 EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE-LEKLKRRLDGESSELQEQMVEQQQRA 1095
Query: 667 KGREEHYEEEEEE--------EEDGAAVAE--KSHRRAE 695
+ +EEE E++G A A+ KS R A+
Sbjct: 1096 EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQ 1134
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 87.4 bits (215), Expect = 4e-17
Identities = 150/729 (20%), Positives = 293/729 (40%), Gaps = 123/729 (16%)
Query: 41 RKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETL 100
R+ + + QQH + L A L+ R +L+ + KK +ED L+
Sbjct: 997 RQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLL-------- 1048
Query: 101 NKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGE---DFSRTFNDHKQKY 157
+D NS+ L+ + ++L+ + E Q ++ EE+ + + + T D + +
Sbjct: 1049 ----EDQNSK---LSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDR- 1100
Query: 158 LQLQQEKEQELSKLKETV----YNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHE-- 211
L+ +++ QEL KLK + L+E+ + ++ +++ QL +++ + L+ E
Sbjct: 1101 LRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDE 1160
Query: 212 -----QLVVTLEDHKSALAAAQ-----TQVAEYK-----------------QLKDTLNRI 244
QL+ +L + ++ALA AQ +VA K +L+DTL+
Sbjct: 1161 GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDST 1220
Query: 245 PSLRKPDPAEQQNVTQ---------------VAHSPQGYNTAREKPTREVQEVSRNNDVW 289
+ ++ +Q VT+ V Q + A + ++++ R W
Sbjct: 1221 NAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAW 1280
Query: 290 Q------NHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKAL 343
+ E RAE + L + + + E QEV+ R + + E + L
Sbjct: 1281 EKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKL 1340
Query: 344 EEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVY--PSAKPMI 401
+ + E + L E + + + +A LL+ RA++ + M
Sbjct: 1341 QRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAME 1400
Query: 402 KFQSPYEEQLEQQRLAVQQVEEAQQLREHQ--EALHQQRLQGHLLRQQEQQQQQVAR--E 457
+ EQLE++ A ++ Q + Q E +Q + L E+ +++ AR E
Sbjct: 1401 AEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAE 1460
Query: 458 MALQRQAE-------LEEGRPQHQEQLRQQAHYDAMDNDIVQGAE------DQGIQGEEG 504
QR AE LE GR + Q++L +V E DQ + E+
Sbjct: 1461 ALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKA 1520
Query: 505 AYERDNQHQDEAEGDPGNRH----------EPREQGPREADPESEADRAAVEDINPADDP 554
A R + ++ AE + R E ++ E + ++ A RA +E + + D
Sbjct: 1521 AVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDD 1580
Query: 555 NNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQ 614
+ E E A +V EQ ++ + + TE+E+ L A + + + + +
Sbjct: 1581 VGKSVHELERACRV---------AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALK 1631
Query: 615 EEAEEEVQ--EDLTEEKKRELEHNAEETYGENDENTDD--------KNNDGEEQEVRDD- 663
+ E ++Q ++ EE++R+L + E DE K +GE +E++
Sbjct: 1632 TQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQM 1691
Query: 664 -NRPKGREE 671
+ +G+EE
Sbjct: 1692 ASAGQGKEE 1700
Score = 73.6 bits (179), Expect = 6e-13
Identities = 149/696 (21%), Positives = 275/696 (39%), Gaps = 92/696 (13%)
Query: 35 ELQTQL----RKAEAVALKYQQHQESLSAQLQVVYEH---RSRLEKSLQKERLEHKKAKE 87
ELQ Q+ ++AE + + + +E L A L + R++L KSL++ + +A+E
Sbjct: 1124 ELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQE 1183
Query: 88 DFLVYKLEAQETLNKGRQDSNSRYSAL-----------NVQHQMLKSQHEELKKQHSDLE 136
D L + A+ K R+D AL N Q ++ + +E+ + LE
Sbjct: 1184 D-LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLE 1242
Query: 137 EEHRKQGEDFSRTFNDHKQKYLQLQQEKEQEL---SKLKETVYNLREENRQLRKAHQDIH 193
EE R H Q +L ++ EQ ++T L E +LR +
Sbjct: 1243 EETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQ 1302
Query: 194 TQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPA 253
T Q+ +Q+ + L + +++ D + A A A ++ + A
Sbjct: 1303 TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQ-----------------A 1345
Query: 254 EQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHK--- 310
E +NV+ N A K R +E+S Q H+A E+T+
Sbjct: 1346 ELENVSGAL------NEAESKTIRLSKELSSTEA--QLHDAQELLQEETRAKLALGSRVR 1397
Query: 311 --EAEFQAPPEPIQQEVERREPEEHQVEEEHRKALE--EEEMEQVGQAEHLEEEHDPSPE 366
EAE E +++E RE +++ + E + E+ G E EE +
Sbjct: 1398 AMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAR 1457
Query: 367 EQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEE---QLEQQRLAVQQVEE 423
E + + E+ E + LE R + Q ++ LEQQR V +E+
Sbjct: 1458 EAEALTQRLAEKTETVDRLERGRR-----------RLQQELDDATMDLEQQRQLVSTLEK 1506
Query: 424 AQQLREHQEALHQQRLQGHLLRQQEQQQ-------QQVAREMALQRQAELEEGRPQHQEQ 476
Q R+ + L +++ +LR E+++ ++ AR ++L R LEE + +E
Sbjct: 1507 KQ--RKFDQLLAEEKAA--VLRAVEERERAEAEGREREARALSLTRA--LEEEQEAREEL 1560
Query: 477 LRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADP 536
RQ A ++ +D G E ER + ++A D + E A+
Sbjct: 1561 ERQNRALRAELEALLSSKDDVGKSVHE--LERACRVAEQAANDLRAQVTELEDELTAAED 1618
Query: 537 ESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHL 596
V+ + + + QG DE E + + + E ++ +KQ V
Sbjct: 1619 AKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARK 1678
Query: 597 VMAGNPDQQEDNVDE--QYQEEAEEEVQEDLTEEKK--RELEH---NAEETYGENDENTD 649
+ G ++ + + Q +EEA +++++ + K+ RE+E + EE + +N E+
Sbjct: 1679 KLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRES-- 1736
Query: 650 DKNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAA 685
+K G E EV + + +++ D A
Sbjct: 1737 EKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMA 1772
Score = 46.2 bits (108), Expect = 1e-04
Identities = 107/518 (20%), Positives = 203/518 (39%), Gaps = 81/518 (15%)
Query: 34 YELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYK 93
+EL+ R AE A + L +L + + RLE ++Q + +H++ +
Sbjct: 1586 HELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAG 1645
Query: 94 LEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDH 153
E + L K +D+ Q + + ++L+ + +L+ + G
Sbjct: 1646 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAG---------- 1695
Query: 154 KQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQL 213
Q ++E ++L K++ + L E + R + ++I +Q ++ +++ K L +E
Sbjct: 1696 -----QGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE---- 1746
Query: 214 VVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYN-TAR 272
V+ L++ LAA+ + +Q +D + D N+++ A + R
Sbjct: 1747 VLRLQEE---LAASDRARRQAQQDRDEM--------ADEVANGNLSKAAILEEKRQLEGR 1795
Query: 273 EKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEE 332
E E ++N N + L E F A E +Q++ER
Sbjct: 1796 LGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLER----- 1850
Query: 333 HQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAE 392
Q++E + EE+ A + + E + + +EQ EQ +L G
Sbjct: 1851 -QIQELRGRLGEED-----AGARARHKMTIAALESKLAQAEEQLEQETRERILSG----- 1899
Query: 393 VYPSAKPMIKFQSPYEEQLEQQRLAVQQVEE----AQQLREHQEALHQQRLQGHLLRQQE 448
K E++L++ V QVEE A QLR+ E + + Q L RQ E
Sbjct: 1900 ---------KLVRRAEKRLKE---VVLQVEEERRVADQLRDQLEKGNLRVKQ--LKRQLE 1945
Query: 449 QQQQQVAREMALQR--QAELEEGRPQHQEQLRQQAHYDAMDNDIVQG-------AEDQGI 499
+ +++ +R A +R Q ELE+ + R+ + N + +G Q
Sbjct: 1946 EAEEEASRAQAGRRRLQRELEDVTESAESMNRE---VTTLRNRLRRGPLTFTTRTVRQVF 2002
Query: 500 QGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPE 537
+ EEG ++ E PG+ P +G A P+
Sbjct: 2003 RLEEGV----ASDEEAEEAQPGSGPSPEPEGSPPAHPQ 2036
Score = 39.7 bits (91), Expect = 0.010
Identities = 65/279 (23%), Positives = 117/279 (41%), Gaps = 25/279 (8%)
Query: 431 QEALHQQRLQGHLLRQQEQQQQQVAREMA-LQ-RQAELEEGRPQHQEQLRQQAHY--DAM 486
Q+ + Q R Q L++ ++ QQQ ARE+ LQ R A+LEE R + EQLR +A +A
Sbjct: 908 QDEVLQARAQE--LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAE 965
Query: 487 DNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVE 546
+ A Q ++ E ++E + +Q +E + EA+ A +
Sbjct: 966 ETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQ 1025
Query: 547 DINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQE 606
+ +FEE + L D+N + + + E+ E + ++E
Sbjct: 1026 KLQLEKVTTEAKMKKFEEDLLL----LEDQNSKLSKERKLLEDRLAE----FSSQAAEEE 1077
Query: 607 DNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRP 666
+ V + + E E++ R+ E +E + D ++++ +EQ V R
Sbjct: 1078 EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE-LEKLKRRLDGESSELQEQMVEQQQRA 1136
Query: 667 KGREEHYEEEEEE--------EEDGAAVAE--KSHRRAE 695
+ +EEE E++G A A+ KS R A+
Sbjct: 1137 EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQ 1175
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 87.0 bits (214), Expect = 5e-17
Identities = 151/705 (21%), Positives = 282/705 (40%), Gaps = 74/705 (10%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKL 94
+L+T+ + + + + LS +L+ H +L+ +L + EH KA +++L +
Sbjct: 301 DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQA 360
Query: 95 EAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEE-HRKQGEDFSRTFNDH 153
+ ++ L+ QD L ++++L+ + +L++ S L++ +++GE
Sbjct: 361 QLEKELSAALQDK----KCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLE 416
Query: 154 KQKY---------LQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHK 204
K QLQ E ++ + L E + Q + + + D++
Sbjct: 417 TLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSIS 476
Query: 205 NLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHS 264
NL E+L + H + L A QVA TLN QQ ++A
Sbjct: 477 NLSQAKEELEQASQAHGARLTA---QVASLTSELTTLN---------ATIQQQDQELAGL 524
Query: 265 PQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQE 324
Q A+EK + Q + Q +A G + + + K+ E Q +QE
Sbjct: 525 KQ---QAKEKQAQLAQTLQ------QQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQE 575
Query: 325 VERRE-PEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAAN 383
R++ ++ E R+A E + Q E LE+E E ++ + +E R++A
Sbjct: 576 ATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQ 635
Query: 384 LLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQ-QLR-EHQEALHQQRLQG 441
A+ E ++ + + Q+ E ++Q A QV E + QLR E Q+A ++R+
Sbjct: 636 TSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQ 695
Query: 442 HLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQ----AHYDAMDNDIVQ----- 492
+ Q Q+Q Q +E + LEE + + + L +Q + A +V+
Sbjct: 696 E--KDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRE 753
Query: 493 ----GAEDQGIQGEEGAYER-DNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVED 547
E G +G E ++ HQ E E R E E + ESE ++ E
Sbjct: 754 RKELEEERAGRKGLEARLQQLGEAHQAETE---VLRRELAEAMAAQHTAESECEQLVKEV 810
Query: 548 INPADDPNNQGEDEFEEAEQVREE--NLPDENEEQKQSNQ--KQENTEVEEHLVMAGNPD 603
+ + ++E + +E+ L +E E+ +Q Q K++ +E H + +
Sbjct: 811 AAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQ 870
Query: 604 QQE-----DNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQ 658
Q E N+ Q+ E+EV+ + L+ T E GE+Q
Sbjct: 871 QNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQ 930
Query: 659 E------VRDDNRPKGREEHYEEEEEEEE--DGAAVAEKSHRRAE 695
E V++ R R+ + EE++ + A + R AE
Sbjct: 931 ETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAE 975
Score = 79.3 bits (194), Expect = 1e-14
Identities = 151/733 (20%), Positives = 289/733 (39%), Gaps = 88/733 (12%)
Query: 29 GAMLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKER--LEHKKAK 86
G +L LQ + K EA L Q L A+++++ R + E L ER E +K +
Sbjct: 406 GEVLGDVLQLETLKQEAATLAANNTQ--LQARVEMLETERGQQEAKLLAERGHFEEEKQQ 463
Query: 87 EDFLVYKLE--------AQETLNKGRQDSNSRYSA----LNVQHQMLKSQHEELKKQHSD 134
L+ L+ A+E L + Q +R +A L + L + ++ ++ +
Sbjct: 464 LSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAG 523
Query: 135 LEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHT 194
L+++ +++ ++T +Q L+ + EQ S LK+ L+E + QD
Sbjct: 524 LKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQ 583
Query: 195 QLQDVKQQHKNLLSEHEQLVVTLEDHKSALAA------------------AQTQVAEYKQ 236
QL ++ + L E + + LE + AA AQT V + ++
Sbjct: 584 QLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQR 643
Query: 237 LKDTLNR-IPSLRK-PDPAEQQN---VTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQN 291
K L+R + L+ + A Q+ QVA + ++K T E + V++ D Q
Sbjct: 644 EKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKAT-EKERVAQEKD--QL 700
Query: 292 HEAVPGRAEDTKLYAPTHKEAEFQAPP--EPIQQEVERREPEEHQVEEEHRKALEEEEME 349
E + E K+ + +E + +A E Q+ + + E + E+H++ +E E E
Sbjct: 701 QEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEE 760
Query: 350 QVG------QAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKF 403
+ G + + L E H E RE E A + A +E K + +
Sbjct: 761 RAGRKGLEARLQQLGEAHQAETEVLRRELAE-------AMAAQHTAESECEQLVKEVAAW 813
Query: 404 QSPYEE-QLEQQRLAVQQVEEAQQLREHQEALHQQ---------RLQGHLLRQQEQQQQQ 453
+ YE+ Q E+ + E+ L+E E Q+ ++ H Q +QQ +
Sbjct: 814 RERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNE 873
Query: 454 VAREMALQRQAELEEGRPQHQE-QLRQQAHYDAMDN-DIVQGAEDQGIQGEEGAYERDNQ 511
+A + A L Q QE ++R Q D + A + + E + +
Sbjct: 874 LA-----ELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGE 928
Query: 512 HQDEAEGDPGNRHEPREQGPREAD-PESEADRAAVEDINPADDPNNQGEDEFEEAEQVRE 570
Q+ A + EP G R+ + E + R + E E E++R
Sbjct: 929 QQETASRELVK--EPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRA 986
Query: 571 ENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEK- 629
+ + ++Q++ Q++ L Q + +++ + E E +Q L E++
Sbjct: 987 ALMESQGQQQEERGQQEREV---ARLTQERGRAQADLALEKAARAELEMRLQNALNEQRV 1043
Query: 630 -----KRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRP--KGREEHYEEEEEEEED 682
+ L H E G++ E + + + + ++ R K +E ++E+E
Sbjct: 1044 EFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHAS 1103
Query: 683 GAAVAEKSHRRAE 695
G+ ++ R E
Sbjct: 1104 GSGAQSEAAGRTE 1116
Score = 73.6 bits (179), Expect = 6e-13
Identities = 140/699 (20%), Positives = 269/699 (38%), Gaps = 101/699 (14%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQL-QVVYEHRSRLEKSLQKERLEHKKAKEDFLVYK 93
EL ++ + +A +Q Q AQ+ ++ + RS +K+ +KER+ +K + +
Sbjct: 647 ELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQA 706
Query: 94 LEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDH 153
L+ + KG + R +A ++ Q + ELK + L E+H+++ ++
Sbjct: 707 LKESLKVTKGSLEEEKRRAADALEEQ--QRCISELKAETRSLVEQHKRERKELEEERAGR 764
Query: 154 KQKYLQLQQEKE----------QELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
K +LQQ E +EL++ + E QL K + +D +Q+
Sbjct: 765 KGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEE 824
Query: 204 KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAH 263
+ ++ ++TL++ + E ++ K+ + I S + + QQN H
Sbjct: 825 AQYGAMFQEQLMTLKEE------CEKARQELQEAKEKVAGIESHSELQISRQQNELAELH 878
Query: 264 S--PQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQ--APPE 319
+ + +EK R Q+++ + Q A + E +L K E Q A E
Sbjct: 879 ANLARALQQVQEKEVR-AQKLADDLSTLQEKMAATSK-EVARLETLVRKAGEQQETASRE 936
Query: 320 PIQQEVERREPEEHQVEEEHRK-------ALEEEEMEQVGQAEHLEEEHDPSPEEQDREW 372
+++ + + +EE+ + AL+ E E LE E Q ++
Sbjct: 937 LVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQ 996
Query: 373 KEQHEQ-REAANLLE--GHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLRE 429
+E+ +Q RE A L + G A+A++ + + + L +QR+ ++EA
Sbjct: 997 EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEA----- 1051
Query: 430 HQEALHQQRLQGHLLRQQEQQQQQVAREMALQ--RQAELEEGRPQHQEQLRQQAHYDAMD 487
H L ++E + Q++A+ L+ + ELEE R Q +QL++Q
Sbjct: 1052 ----------LAHALTEKEGKDQELAKLRGLEAAQIKELEELR-QTVKQLKEQL------ 1094
Query: 488 NDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVED 547
E+++ A+ + R EP P+ EA RA V
Sbjct: 1095 ----------------AKKEKEHASGSGAQSEAAGRTEP-------TGPKLEALRAEVSK 1131
Query: 548 INPADDPNNQGEDEFE---EAEQVRE-------ENLPDENEEQKQ--SNQKQENTEVEEH 595
+ + D E EAE+ E L + EE+ Q + + +
Sbjct: 1132 LEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRE 1191
Query: 596 LVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDG 655
L Q +++++ + QE E+K L + EE + +K +
Sbjct: 1192 LAAFRTKVQDHSKAEDEWKAQVARGRQE---AERKNSLISSLEEEVSILNRQVLEKEGES 1248
Query: 656 EEQE----VRDDNRPKGREEHYEEEEEEEEDGAAVAEKS 690
+E + + K E + E + A AE+S
Sbjct: 1249 KELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERS 1287
Score = 65.1 bits (157), Expect = 2e-10
Identities = 136/615 (22%), Positives = 241/615 (39%), Gaps = 93/615 (15%)
Query: 61 LQVVYEHRSRLEKSLQKER-----LEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALN 115
LQ RL+K L ER LE + A+ L+ + +AQ + + R D R + LN
Sbjct: 209 LQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRID---RLALLN 265
Query: 116 VQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETV 175
+ + +EL EE R + E + ++ ++ L+ EK Q K+ +
Sbjct: 266 EKQAASPLEPKEL--------EELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQ-- 315
Query: 176 YNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYK 235
L EEN L ++ + LQ ++ L EH K+ + Q K
Sbjct: 316 --LSEENGDLSFKLREFASHLQQLQDALNELTEEHS---------KATQEWLEKQAQLEK 364
Query: 236 QLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAV 295
+L L L + + Q ++Q+ + + ++ P +E EV DV Q
Sbjct: 365 ELSAALQDKKCLEEKNEILQGKLSQL---EEHLSQLQDNPPQEKGEVL--GDVLQ----- 414
Query: 296 PGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEE---HRKALEEEEMEQVG 352
L + A A +Q VE E E Q E + R EEE+ +
Sbjct: 415 --------LETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSS 466
Query: 353 QAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLE 412
L+ S Q +E EQ Q A L A+V + + ++Q +
Sbjct: 467 LITDLQS--SISNLSQAKEELEQASQAHGARL-----TAQVASLTSELTTLNATIQQQDQ 519
Query: 413 Q-----QRLAVQQVEEAQQLREHQEA----LHQQRLQGHLLRQQEQQQQQVAREMALQRQ 463
+ Q+ +Q + AQ L++ ++A HQ L+Q+EQQ ++VA + RQ
Sbjct: 520 ELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQ 579
Query: 464 AELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNR 523
++ +E+ DA + + ++ E+ A Q Q + +
Sbjct: 580 DHAQQLATAAEEREASLRERDAALKQL------EALEKEKAAKLEILQQQLQVANE---A 630
Query: 524 HEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQS 583
+ + +A E VE++ + Q ++ E QV E L +E+QK +
Sbjct: 631 RDSAQTSVTQAQREKAELSRKVEELQACVETARQ--EQHEAQAQVAELELQLRSEQQKAT 688
Query: 584 NQK---QENTEVEEHL--------VMAGNPDQQE----DNVDEQYQEEAEEEVQ-EDLTE 627
++ QE +++E L V G+ ++++ D ++EQ + +E + + L E
Sbjct: 689 EKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE 748
Query: 628 EKKRELEHNAEETYG 642
+ KRE + EE G
Sbjct: 749 QHKRERKELEEERAG 763
Score = 64.7 bits (156), Expect = 3e-10
Identities = 139/671 (20%), Positives = 253/671 (37%), Gaps = 69/671 (10%)
Query: 39 QLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDF---LVYKLE 95
Q R+ + + + Q L+ + E RL+ +L ++R+E +E L K
Sbjct: 1002 QEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEG 1061
Query: 96 AQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQ 155
+ L K R ++ L Q +K E+L K+ + Q E RT +
Sbjct: 1062 KDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPK 1121
Query: 156 KYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVV 215
+ E+SKL++ +E+ L ++ + + + L + E+
Sbjct: 1122 L-----EALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQ 1176
Query: 216 TLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKP 275
L +SALA+AQ ++A ++ ++ AE + QVA Q
Sbjct: 1177 ELGHSQSALASAQRELAAFRT---------KVQDHSKAEDEWKAQVARGRQEAERKNSLI 1227
Query: 276 TREVQEVSRNNDVWQNHEAVPGRAEDTK--LYAPTHKEAEFQAPPEPIQQEV---ERREP 330
+ +EVS N E G +++ K + A + K + + +Q E R
Sbjct: 1228 SSLEEEVSILNRQVLEKE---GESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAA 1284
Query: 331 EEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQD------REWKEQHEQREAA-- 382
E E ++L EE +Q +E+L +E E + + W+E+ Q+E A
Sbjct: 1285 ERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALS 1344
Query: 383 NLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQ-QVEEAQQLREHQEALHQQRLQG 441
L H + S E L + L Q Q E+A + H+E L Q +
Sbjct: 1345 TLQLEHTSTQALVS------------ELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAA 1392
Query: 442 HLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQG 501
LR + + Q+ E+ RQ E+ R +QLR + A +++ A +
Sbjct: 1393 GGLRAELLRAQRELGELIPLRQKVAEQERT--AQQLRAEKASYAEQLSMLKKAHGLLAEE 1450
Query: 502 EEGAYERDNQHQD--EAEGDPGNRHEPREQGPREADPE---SEADRAAVEDINPADDPNN 556
G ER N + E E D +E AD E +E R A +
Sbjct: 1451 NRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTA 1510
Query: 557 QGEDE----FEEAEQVREENLP-DENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDE 611
+ E EE ++ +EE EQ + Q+++ +VEE + D Q V +
Sbjct: 1511 KYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSD-QASKVQQ 1569
Query: 612 QYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREE 671
Q + + + E E ++ + + N E K E +++ + +
Sbjct: 1570 QKLKAVQAQGGESQQEAQRLQAQLN------ELQAQLSQKEQAAEHYKLQMEK----AKT 1619
Query: 672 HYEEEEEEEED 682
HY+ ++++ ++
Sbjct: 1620 HYDAKKQQNQE 1630
Score = 57.4 bits (137), Expect = 4e-08
Identities = 108/471 (22%), Positives = 191/471 (40%), Gaps = 50/471 (10%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKL 94
E + Q+ + A + SL ++ ++ +R LEK + + L+ E KL
Sbjct: 1208 EWKAQVARGRQEAERKNSLISSLEEEVSIL--NRQVLEKEGESKELKRLVMAESEKSQKL 1265
Query: 95 EAQETLNKGRQDSNS-----RYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGE---DF 146
E + L + SNS R SAL + Q L+ + E+ + +L +E Q E +
Sbjct: 1266 EERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEEL 1325
Query: 147 SRTFNDHKQKYLQLQQEKEQELSKLK---ETVYNLREENRQLRKAHQDIHTQLQDVKQQH 203
+ ++K+ Q KEQ LS L+ + L E + Q + + +++H
Sbjct: 1326 GQELKAWQEKFFQ----KEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRH 1381
Query: 204 KNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTL----NRIPSLR--KPDPAEQQN 257
+ L + +Q L ++ L AQ ++ E L+ + LR K AEQ +
Sbjct: 1382 REELEQSKQAAGGL---RAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLS 1438
Query: 258 VTQVAHS-------PQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHK 310
+ + AH G + EV+ Q AV AE T+L A +
Sbjct: 1439 MLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAE-TRL-AEVQR 1496
Query: 311 EAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDR 370
EA Q+ ++ + E + +V EE R+ +EE + Q E LE ++ +
Sbjct: 1497 EA--QSTARELEVMTAKYEGAKVKVLEE-RQRFQEERQKLTAQVEQLEVFQREQTKQVEE 1553
Query: 371 EWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREH 430
K+ + +A+ + + +A ++ Q E Q E QRL Q E QL +
Sbjct: 1554 LSKKLADSDQASKVQQQKLKA---------VQAQGG-ESQQEAQRLQAQLNELQAQLSQK 1603
Query: 431 QEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQA 481
++A +LQ + ++Q +E LQ Q E + ++LR +A
Sbjct: 1604 EQAAEHYKLQMEKAKTHYDAKKQQNQE--LQEQLRSLEQLQKENKELRAEA 1652
Score = 49.3 bits (116), Expect = 1e-05
Identities = 57/239 (23%), Positives = 106/239 (44%), Gaps = 28/239 (11%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRL------------EKSLQKERLEH 82
E Q+ R+ E + KY+ + + + Q E R +L E++ Q E L
Sbjct: 1497 EAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSK 1556
Query: 83 KKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEE--EHR 140
K A D K++ Q+ Q S+ A Q L++Q EL+ Q S E+ EH
Sbjct: 1557 KLADSD-QASKVQQQKLKAVQAQGGESQQEA-----QRLQAQLNELQAQLSQKEQAAEHY 1610
Query: 141 KQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVK 200
K + ++T D K+ Q QE +++L L++ L++EN++LR + + +LQ
Sbjct: 1611 KLQMEKAKTHYDAKK---QQNQELQEQLRSLEQ----LQKENKELRAEAERLGHELQQAG 1663
Query: 201 QQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVT 259
+ K L + ++ +A A Q+ + + + + + S R+P Q +++
Sbjct: 1664 LKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKS-REPQAKPQLDLS 1721
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 86.7 bits (213), Expect = 7e-17
Identities = 146/694 (21%), Positives = 287/694 (41%), Gaps = 100/694 (14%)
Query: 77 KERLEHKKAKEDFLVYKLEAQETLN-KGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDL 135
K+ LE +K+K V +L+ Q L K +Q+ + + L+SQH E +++S L
Sbjct: 610 KDLLE-QKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTL 668
Query: 136 EEE-HRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQD--- 191
++ +GE + ++ Q++ E+EQ +++++ L E + +L A +
Sbjct: 669 QQRLEESEGE-----LRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDR 723
Query: 192 ----IHTQLQDVKQQHKNLL---SEHEQLVVTLEDHKSALAAA-QTQVAEYKQLKDTLNR 243
+ +L KQ ++LL E E L+ E +AL A + +V+ + Q D L
Sbjct: 724 EKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKE 783
Query: 244 -----IPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGR 298
+ +LR+ +NV +A NT+ + V + + +E + GR
Sbjct: 784 QYDAELQALRESVEEATKNVEVLASRS---NTSEQDQAGTEMRVKL---LQEENEKLQGR 837
Query: 299 AEDT-KLYAPTHKEAE-FQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEH 356
+E+ + A ++ E + ++ +++ E E Q+EE A +EE+ E V
Sbjct: 838 SEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEK-EAVSARRA 896
Query: 357 LEEEHDPSP----------EEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSP 406
LE E + + ++ + KE+ EQ+E L+ E + K + K Q
Sbjct: 897 LENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKE 956
Query: 407 YEEQLEQQRLAVQQVEEA---------QQLREHQEALHQQRLQGHLLR------------ 445
+ +E R + +++ ++L E Q L ++ L+ R
Sbjct: 957 MADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRL 1016
Query: 446 -QQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEG 504
++E + Q A++ AL ++ LE+ + +L ++H + +V+ ED+ + E
Sbjct: 1017 MEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDK-VSQLEM 1075
Query: 505 AYERDNQHQDEAEGDPGNRHEPREQ------GPREADPESEADRAAVEDINP-------- 550
E + + D E EQ R A + E D+ ++E N
Sbjct: 1076 ELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIH 1135
Query: 551 ADDPNNQGEDEFEEAEQVREENLPD--ENEEQKQSNQKQENTEVE------------EHL 596
+ ++ + R L D E+EE+ ++N + N +E EHL
Sbjct: 1136 LEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHL 1195
Query: 597 VMAGNPDQQEDNVD--EQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNND 654
+ DQ + ++ EEAEEE+ D E K++L+ EE N+ N+
Sbjct: 1196 SLTDQKDQLSLRLKAMKRQVEEAEEEI--DRLESSKKKLQRELEEQMDMNEHLQGQLNS- 1252
Query: 655 GEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVAE 688
++++R P + +++++ DG ++ E
Sbjct: 1253 -MKKDLRLKKLPSKVLDDMDDDDDLSTDGGSLYE 1285
Score = 45.1 bits (105), Expect = 2e-04
Identities = 67/332 (20%), Positives = 140/332 (42%), Gaps = 62/332 (18%)
Query: 35 ELQTQL------RKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERL-EHKKAKE 87
ELQ QL + E ++ Q +++L A+ + + + E L +E L ++++A++
Sbjct: 970 ELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQD 1029
Query: 88 DFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFS 147
+ L + ++TL + ++ + + +++K +++ + +LEEE R + S
Sbjct: 1030 EALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE-RNNSDLLS 1088
Query: 148 RTFNDHKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLL 207
+ +S+ +E + LR E Q R A QD+ +++Q+K+L
Sbjct: 1089 ------------------ERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLK 1130
Query: 208 SEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQG 267
S L + K L A +L+D L + + ++ N+ Q
Sbjct: 1131 SRIIHLEGSYRSSKEGLVVQME--ARIAELEDRL-------ESEERDRANL-------QL 1174
Query: 268 YNTAREKPTRE-VQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVE 326
N E+ +E V +V D + + T ++ + + ++++VE
Sbjct: 1175 SNRRLERKVKELVMQV------------------DDEHLSLTDQKDQLSLRLKAMKRQVE 1216
Query: 327 RREPEEHQVEEEHRKALEEEEMEQVGQAEHLE 358
E E ++E +K L+ E EQ+ EHL+
Sbjct: 1217 EAEEEIDRLESS-KKKLQRELEEQMDMNEHLQ 1247
Score = 44.3 bits (103), Expect = 4e-04
Identities = 62/269 (23%), Positives = 112/269 (41%), Gaps = 39/269 (14%)
Query: 417 AVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQ 476
A E + L E + L + + Q E + QQ +E + +A LEE R QH E+
Sbjct: 602 ACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEK 661
Query: 477 LRQ----QAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDE---AEGDPGNRHEPREQ 529
+ + Q + + ++ + E+ + ER+ QHQ E + H+ +
Sbjct: 662 VEENSTLQQRLEESEGELRKNLEEL----FQVKMERE-QHQTEIRDLQDQLSEMHDELDS 716
Query: 530 GPREADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQEN 589
R D E A +E++ A Q + A++ +E+L + E + + +
Sbjct: 717 AKRSEDREK---GALIEELLQA----KQDLQDLLIAKE-EQEDLLRKRERELTALKGALK 768
Query: 590 TEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTD 649
EV H DQ+ D + EQY +AE + + EE + +E A + NT
Sbjct: 769 EEVSSH-------DQEMDKLKEQY--DAELQALRESVEEATKNVEVLASRS------NTS 813
Query: 650 DKNNDGEEQEVR----DDNRPKGREEHYE 674
+++ G E V+ ++ + +GR E E
Sbjct: 814 EQDQAGTEMRVKLLQEENEKLQGRSEELE 842
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 86.3 bits (212), Expect = 9e-17
Identities = 159/744 (21%), Positives = 301/744 (40%), Gaps = 122/744 (16%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKL 94
EL+ L + EA + + + L A+ + + + LE+ L++E + A++ + K+
Sbjct: 926 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE----EAARQKLQLEKV 981
Query: 95 EAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHK 154
A+ + K + ++ Q+ L + + L+++ SDL ++ E+ ++ K
Sbjct: 982 TAEAKIKKLEDE----ILVMDDQNNKLSKERKLLEERISDLTTNLAEE-EEKAKNLTKLK 1036
Query: 155 QKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLV 214
K+ + E E L K +++ L + R+L D H Q+ D++ Q L QL
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM---QLA 1093
Query: 215 VTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREK 274
E+ ++ALA ++A Q + L +I L + +++ + AR K
Sbjct: 1094 KKEEELQAALARLDDEIA---QKNNALKKIREL-------EGHISDLQEDLDSERAARNK 1143
Query: 275 PTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPE------PIQQEVERR 328
++ D+ + EA+ EDT T +E + E + +E
Sbjct: 1144 AEKQ------KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 329 EPEEHQVEEEHRKALEE--EEMEQ----------------------------VGQA---- 354
E + ++ ++H +A+EE E++EQ +GQA
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 355 EHLEEEHDPSPEE---------------QDREWKEQHEQREAANLLEGHARAEVYPSAKP 399
EH +++ + +E D+ K Q+E +L A + AK
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN-EAEGKAIKLAKD 1316
Query: 400 MIKFQSPYEEQLE------QQRLAV----QQVEEAQ-----QLREHQEALHQQRLQGHL- 443
+ S ++ E +Q+L V +Q+EE + QL E EA +Q L+ H+
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA--KQNLERHIS 1374
Query: 444 -LRQQEQQQQQVAREMALQRQAELEEGRPQHQ---EQLRQQAHYDAMDNDIVQGAEDQGI 499
L Q ++ ++ A +A LEEG+ + Q E L QQ A D ++ +++
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEA-LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433
Query: 500 QG-EEGAYERDNQHQDEAEGDPGNRH------EPREQGPREADPESEADRAAVEDINPAD 552
Q ++ + DNQ Q + + R E + + AD A+ A E A
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 553 DPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQ 612
E+ E E++ N + E + + K + + L + + + +
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553
Query: 613 YQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEH 672
EE E+E+Q TE+ K LE N + G+ + + ++ EE+ R R+ H
Sbjct: 1554 QLEELEDELQA--TEDAKLRLEVNMQALKGQFERDLQARDEQNEEK-----RRQLQRQLH 1606
Query: 673 -YEEEEEEEEDGAAVAEKSHRRAE 695
YE E E+E A+A + ++ E
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLE 1630
Score = 77.4 bits (189), Expect = 4e-14
Identities = 134/636 (21%), Positives = 254/636 (39%), Gaps = 73/636 (11%)
Query: 40 LRKAEAVALKYQQHQESLSAQLQ-----VVYEHRSRLEKSLQKERLEHKK-AKEDFLVYK 93
L +AE A+K + SLS+QLQ + E R +L S + +LE ++ + +D L +
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362
Query: 94 LEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEE---EHRKQGEDFSRTF 150
+EA++ L + S LN+Q K + ++ LEE +K+ E+ ++ +
Sbjct: 1363 MEAKQNLER-------HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1415
Query: 151 NDHKQKYLQLQQEK---EQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLL 207
+ Y +L++ K +QEL L + N R+ L K + L + K
Sbjct: 1416 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475
Query: 208 SEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQ--------QNVT 259
E ++ + ++ + + E + K+ L R + K + + +NV
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535
Query: 260 QVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPE 319
++ S + T E+ +++E+ D Q E R E E + QA E
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELE---DELQATEDAKLRLEVNMQALKGQFERDLQARDE 1592
Query: 320 PIQQEVERREPEEHQVEEEHRKALEEEEMEQV----------GQAEHLEEEHDPSPEEQD 369
+++ + + + H+ E E LE+E ++ G + LE + D + + ++
Sbjct: 1593 QNEEKRRQLQRQLHEYETE----LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648
Query: 370 REWKE----QHEQREAANLLEGH--ARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEE 423
K+ Q + ++ LE +R E++ +AK K E L Q + + E
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1708
Query: 424 AQQLREHQEALHQQRLQGHLLRQ---QEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQ 480
A++ + ++ + L L + Q+++++ AR L+ + E E+G + ++
Sbjct: 1709 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1768
Query: 481 AHYDAMDNDIVQGAEDQGIQGEEGA---YERDNQHQ----DEAEGDPGNRHEPR------ 527
A A E Q E A ER N+ E EG ++ +
Sbjct: 1769 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1828
Query: 528 --EQGPREADPESEADRAAVEDINPADDPNN----QGEDEFEEAEQVREENLPDENEEQK 581
Q + + E+ +AA + + D Q EDE + AEQ +E+ N K
Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ-AEKGNARVK 1887
Query: 582 QSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEA 617
Q ++ E E E + A Q + + EA
Sbjct: 1888 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1923
Score = 63.2 bits (152), Expect = 8e-10
Identities = 110/487 (22%), Positives = 206/487 (42%), Gaps = 46/487 (9%)
Query: 40 LRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQET 99
L + + ++ KY ++ A+ + L ++L+ E LE K+ E E
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALE-EALEAKEELERTNKMLKAEMED 1522
Query: 100 LNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQ 159
L + D L + L++Q EE+K Q +LE+E + ED + Q
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT-EDAKLRLEVNMQA--- 1578
Query: 160 LQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLED 219
L+ + E++L E E+ RQL++ + T+L+D ++Q + ++L L+D
Sbjct: 1579 LKGQFERDLQARDE---QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 220 -HKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTRE 278
A +A + + KQL+ ++ + K E ++ A + + TA+E E
Sbjct: 1636 LELQADSAIKGREEAIKQLR----KLQAQMKDFQRELEDAR--ASRDEIFATAKE---NE 1686
Query: 279 VQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKE------AEFQAPPEPIQQEVERREPEE 332
+ S D+ Q E + AE + A KE A + +Q E R E
Sbjct: 1687 KKAKSLEADLMQLQEDL-AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1745
Query: 333 HQVEEE------HRKALEEEEMEQVGQAEHLEEE--HDPSPEEQDREWKEQHEQ-----R 379
Q+EEE + +A+ + + QAE L E + S +++ ++Q E+ R
Sbjct: 1746 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1805
Query: 380 EAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEA--QQLREHQEALHQQ 437
+ +EG +++ + + + EEQ+EQ+ Q ++ Q+ ++ +E L Q
Sbjct: 1806 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV 1865
Query: 438 RLQGHLLRQ-QEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAED 496
+ + Q +EQ ++ AR L+RQ E E +E R A+ + ++ + E
Sbjct: 1866 EDERKMAEQYKEQAEKGNARVKQLKRQLEEAE-----EESQRINANRRKLQRELDEATES 1920
Query: 497 QGIQGEE 503
G E
Sbjct: 1921 NEAMGRE 1927
Score = 51.2 bits (121), Expect = 3e-06
Identities = 105/541 (19%), Positives = 216/541 (39%), Gaps = 52/541 (9%)
Query: 136 EEEHRKQGEDFSRTFNDHKQKY---LQLQQEKEQELSKLKETVYNLREENRQLRKAHQDI 192
+EE + ED + + +QK L+ ++K +L++ K + + +L +++
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 193 HTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDP 252
+L KQ+ + +L E E + ED L A + ++A+ L+ L + +
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ-----QMLDLEEQLEEEEA 971
Query: 253 AEQQNVTQVAHSPQGYNTAREKPTREVQEV----SRNNDVWQNHEAVPGRAEDTKLYAPT 308
A Q+ + TA K + E+ +NN + + + + R D
Sbjct: 972 ARQKLQLEKV-------TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 309 HKE-----AEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEE---E 360
+E + + E + E+E R + EE+ R+ LE+ + + G A E +
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKK----EEKSRQELEKLKRKLEGDASDFHEQIAD 1080
Query: 361 HDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQ---SPYEEQLEQQRLA 417
E + ++ E+ +AA A+ + K + + + S +E L+ +R A
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1140
Query: 418 VQQVE-EAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQ-RQAELEEGRPQHQE 475
+ E + + L E EAL + L+ L QQ+ + RE + + L+E H+
Sbjct: 1141 RNKAEKQKRDLGEELEAL-KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1199
Query: 476 QLRQ--QAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPRE 533
Q+++ Q H A++ ++ + E + + +++ Q ++ D Q +E
Sbjct: 1200 QVQEMRQKHAQAVE-ELTEQLEQ--FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256
Query: 534 ADPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVE 593
+ + + A V+++ + E + + L +E E + E ++
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELND----KVHKLQNEVESVTGMLNEAEGKAIK 1312
Query: 594 EHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDL-TEEKKRELEHNAEETYGENDENTDDKN 652
+A Q +D QE +EE ++ L K R+LE + DE + K
Sbjct: 1313 LAKDVASLSSQLQDT-----QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367
Query: 653 N 653
N
Sbjct: 1368 N 1368
Score = 50.8 bits (120), Expect = 4e-06
Identities = 78/379 (20%), Positives = 147/379 (38%), Gaps = 44/379 (11%)
Query: 35 ELQTQLRKAEAVALKYQQHQESLSAQ----LQVVYEHRSRLEKSLQKERLEHKKAKEDFL 90
EL+ +L+ E L+ + + ++L Q LQ E + LQ++ E++ ED
Sbjct: 1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616
Query: 91 VYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTF 150
+ A K D L +Q EE KQ L+ Q +DF R
Sbjct: 1617 KQRALAAAAKKKLEGDLKD----LELQADSAIKGREEAIKQLRKLQA----QMKDFQREL 1668
Query: 151 ND---HKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLL 207
D + + +E E++ L+ + L+E+ +A + + +++ ++ + L
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Query: 208 SEHE--------------QLVVTLEDHKSALAAAQTQVAEYKQLKDTL-NRIPSLR---- 248
S QL LE+ + + A +V + Q + L N + + R
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 249 KPDPAEQQ------NVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDT 302
K + A QQ + H +G ++ K T E + Q E V A +
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK----IAQLEEQVEQEAREK 1844
Query: 303 KLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHD 362
+ + K+ + + +Q E ER+ E+++ + E A ++ Q+ +AE + +
Sbjct: 1845 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904
Query: 363 PSPEEQDREWKEQHEQREA 381
+ + RE E E EA
Sbjct: 1905 ANRRKLQRELDEATESNEA 1923
Score = 49.7 bits (117), Expect = 9e-06
Identities = 83/398 (20%), Positives = 160/398 (40%), Gaps = 47/398 (11%)
Query: 34 YELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQ-------------KERL 80
+EL+ R E + + E L +LQ + + RLE ++Q E+
Sbjct: 1535 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1594
Query: 81 EHKKAKEDFLVYKLEAQ-ETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEH 139
E K+ + +++ E + E K R + + L + L+ Q + K + ++
Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1654
Query: 140 RK---QGEDFSRTFND---HKQKYLQLQQEKEQELSKLKETVYNLREENRQLRKAHQDIH 193
RK Q +DF R D + + +E E++ L+ + L+E+ +A +
Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Query: 194 TQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPA 253
+ +++ ++ + LS L+D K L A Q+ E +L++ + ++
Sbjct: 1715 LEKEELAEELASSLSGRN----ALQDEKRRLEARIAQLEE--ELEEEQGNMEAMSDRVRK 1768
Query: 254 EQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQN--HE---AVPGRAEDT------ 302
Q Q+++ + +K Q++ R N ++ HE AV + + T
Sbjct: 1769 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1828
Query: 303 ---KLYAPTHKEA-EFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQA---- 354
+L +EA E QA + ++Q+ ++ + QVE+E + A + +E + G A
Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1888
Query: 355 --EHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHAR 390
LEE + S K Q E EA E R
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGR 1926
Score = 47.4 bits (111), Expect = 5e-05
Identities = 85/395 (21%), Positives = 156/395 (39%), Gaps = 74/395 (18%)
Query: 328 REPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEG 387
R+ EE Q +E+ + +E + + + + LE++H EE+ NLL+
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK--------------NLLQE 901
Query: 388 --HARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLR 445
A E+Y A+ M + RLA ++ E + L E + L ++ +G L
Sbjct: 902 QLQAETELYAEAEEM------------RVRLAAKKQELEEILHEMEARLEEEEDRGQQL- 948
Query: 446 QQEQQQQQVAREMALQRQAELEEGRPQ--HQEQLRQQAHYDAMDNDI-VQGAEDQGIQGE 502
Q ++++ + + L+ Q E EE Q E++ +A ++++I V ++ + E
Sbjct: 949 -QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1007
Query: 503 EGAYER------DNQHQDEAEGDP----GNRHEPREQGPREADPESEADRAAVEDI---- 548
E N ++E + N+HE + E R +E +
Sbjct: 1008 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067
Query: 549 -NPADDPNNQGEDEFEEAEQVREENLPDENEEQ-----------KQSNQKQENTEVEEHL 596
A D + Q D + +++ + E E Q +++N ++ E+E H+
Sbjct: 1068 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 597 VMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEE---KKRELEHNAEETYGEND-------E 646
D QED E+ E+ + DL EE K ELE + T + + E
Sbjct: 1128 -----SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1182
Query: 647 NTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEE 681
T K EE + + R++H + EE E
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.123 0.332
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,280,473
Number of Sequences: 37866
Number of extensions: 1646324
Number of successful extensions: 51481
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 920
Number of HSP's successfully gapped in prelim test: 1525
Number of HSP's that attempted gapping in prelim test: 10590
Number of HSP's gapped (non-prelim): 16603
length of query: 696
length of database: 18,247,518
effective HSP length: 109
effective length of query: 587
effective length of database: 14,120,124
effective search space: 8288512788
effective search space used: 8288512788
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.