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Search of human proteins with 75750468
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|75750468 spectrin domain with coiled-coils 1 NSP5a3a [Homo
sapiens]
(709 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|75750468 spectrin domain with coiled-coils 1 NSP5a3a [Homo sa... 1375 0.0
gi|75750474 spectrin domain with coiled-coils 1 NSP5a3b [Homo sa... 1365 0.0
gi|75750466 spectrin domain with coiled-coils 1 NSP5b3a [Homo sa... 1345 0.0
gi|75750472 spectrin domain with coiled-coils 1 NSP5b3b [Homo sa... 1335 0.0
gi|224451082 cytospin A [Homo sapiens] 421 e-118
gi|224451080 cytospin A [Homo sapiens] 421 e-118
gi|38044112 restin isoform b [Homo sapiens] 102 2e-21
gi|4506751 restin isoform a [Homo sapiens] 102 2e-21
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 100 4e-21
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 99 2e-20
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 96 9e-20
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 96 1e-19
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 96 1e-19
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 94 4e-19
gi|71061468 centromere protein E [Homo sapiens] 94 4e-19
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 93 1e-18
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 93 1e-18
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 92 2e-18
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 91 4e-18
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 90 6e-18
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 90 6e-18
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 88 2e-17
gi|21735548 centrosomal protein 2 [Homo sapiens] 88 2e-17
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 88 2e-17
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 88 2e-17
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 88 3e-17
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 88 3e-17
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 88 3e-17
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 86 1e-16
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 86 1e-16
>gi|75750468 spectrin domain with coiled-coils 1 NSP5a3a [Homo
sapiens]
Length = 709
Score = 1375 bits (3558), Expect = 0.0
Identities = 709/709 (100%), Positives = 709/709 (100%)
Query: 1 MGNHSGRPEDPEPGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTP 60
MGNHSGRPEDPEPGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTP
Sbjct: 1 MGNHSGRPEDPEPGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTP 60
Query: 61 TPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLN 120
TPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLN
Sbjct: 61 TPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLN 120
Query: 121 AEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSP 180
AEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSP
Sbjct: 121 AEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSP 180
Query: 181 NSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTK 240
NSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTK
Sbjct: 181 NSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTK 240
Query: 241 ASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME 300
ASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME
Sbjct: 241 ASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME 300
Query: 301 ENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENE 360
ENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENE
Sbjct: 301 ENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENE 360
Query: 361 KLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEE 420
KLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEE
Sbjct: 361 KLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEE 420
Query: 421 NQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGE 480
NQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGE
Sbjct: 421 NQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGE 480
Query: 481 KQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAK 540
KQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAK
Sbjct: 481 KQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAK 540
Query: 541 VEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLH 600
VEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLH
Sbjct: 541 VEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLH 600
Query: 601 NNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCE 660
NNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCE
Sbjct: 601 NNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCE 660
Query: 661 AQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPSLGSVS 709
AQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPSLGSVS
Sbjct: 661 AQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPSLGSVS 709
>gi|75750474 spectrin domain with coiled-coils 1 NSP5a3b [Homo
sapiens]
Length = 987
Score = 1365 bits (3532), Expect = 0.0
Identities = 703/703 (100%), Positives = 703/703 (100%)
Query: 1 MGNHSGRPEDPEPGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTP 60
MGNHSGRPEDPEPGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTP
Sbjct: 1 MGNHSGRPEDPEPGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTP 60
Query: 61 TPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLN 120
TPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLN
Sbjct: 61 TPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLN 120
Query: 121 AEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSP 180
AEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSP
Sbjct: 121 AEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSP 180
Query: 181 NSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTK 240
NSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTK
Sbjct: 181 NSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTK 240
Query: 241 ASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME 300
ASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME
Sbjct: 241 ASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME 300
Query: 301 ENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENE 360
ENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENE
Sbjct: 301 ENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENE 360
Query: 361 KLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEE 420
KLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEE
Sbjct: 361 KLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEE 420
Query: 421 NQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGE 480
NQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGE
Sbjct: 421 NQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGE 480
Query: 481 KQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAK 540
KQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAK
Sbjct: 481 KQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAK 540
Query: 541 VEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLH 600
VEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLH
Sbjct: 541 VEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLH 600
Query: 601 NNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCE 660
NNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCE
Sbjct: 601 NNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCE 660
Query: 661 AQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAAPP 703
AQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAAPP
Sbjct: 661 AQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAAPP 703
>gi|75750466 spectrin domain with coiled-coils 1 NSP5b3a [Homo
sapiens]
Length = 790
Score = 1345 bits (3481), Expect = 0.0
Identities = 696/696 (100%), Positives = 696/696 (100%)
Query: 14 GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKP 73
GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKP
Sbjct: 95 GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKP 154
Query: 74 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 133
KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG
Sbjct: 155 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 214
Query: 134 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS 193
TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS
Sbjct: 215 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS 274
Query: 194 CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI 253
CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI
Sbjct: 275 CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI 334
Query: 254 TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT 313
TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT
Sbjct: 335 TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT 394
Query: 314 LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE 373
LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE
Sbjct: 395 LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE 454
Query: 374 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 433
EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE
Sbjct: 455 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 514
Query: 434 ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT 493
ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT
Sbjct: 515 ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT 574
Query: 494 AESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICD 553
AESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICD
Sbjct: 575 AESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICD 634
Query: 554 HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI 613
HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI
Sbjct: 635 HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI 694
Query: 614 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL 673
KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL
Sbjct: 695 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL 754
Query: 674 EEEEKNARLQKELGDVQGHGRVVTSRAAPPSLGSVS 709
EEEEKNARLQKELGDVQGHGRVVTSRAAPPSLGSVS
Sbjct: 755 EEEEKNARLQKELGDVQGHGRVVTSRAAPPSLGSVS 790
>gi|75750472 spectrin domain with coiled-coils 1 NSP5b3b [Homo
sapiens]
Length = 1068
Score = 1335 bits (3455), Expect = 0.0
Identities = 690/690 (100%), Positives = 690/690 (100%)
Query: 14 GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKP 73
GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKP
Sbjct: 95 GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKP 154
Query: 74 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 133
KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG
Sbjct: 155 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 214
Query: 134 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS 193
TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS
Sbjct: 215 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS 274
Query: 194 CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI 253
CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI
Sbjct: 275 CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI 334
Query: 254 TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT 313
TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT
Sbjct: 335 TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT 394
Query: 314 LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE 373
LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE
Sbjct: 395 LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE 454
Query: 374 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 433
EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE
Sbjct: 455 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 514
Query: 434 ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT 493
ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT
Sbjct: 515 ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT 574
Query: 494 AESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICD 553
AESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICD
Sbjct: 575 AESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICD 634
Query: 554 HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI 613
HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI
Sbjct: 635 HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI 694
Query: 614 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL 673
KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL
Sbjct: 695 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL 754
Query: 674 EEEEKNARLQKELGDVQGHGRVVTSRAAPP 703
EEEEKNARLQKELGDVQGHGRVVTSRAAPP
Sbjct: 755 EEEEKNARLQKELGDVQGHGRVVTSRAAPP 784
>gi|224451082 cytospin A [Homo sapiens]
Length = 1117
Score = 421 bits (1083), Expect = e-118
Identities = 266/707 (37%), Positives = 410/707 (57%), Gaps = 43/707 (6%)
Query: 14 GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPS--- 70
G ++TKR+ +E S T R R R + +K S+ +N K R+ +
Sbjct: 103 GTASSTKRSTSTGNKESSSTRERLRERTR-LNQSKKLPSAGQGANDMALAKRSRSRTATE 161
Query: 71 -----TKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTD 125
+K K +N+ ++AALE++V++LL AK KD EI LR+EL+ + + +N + ++
Sbjct: 162 CDVRMSKSKSDNQISDRAALEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSE 221
Query: 126 ALGPNVDGTSVS--PGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHS---- 179
+ T ++ P D E + L+E+N ++EL+ L+ ENR+LK++L L S
Sbjct: 222 GDEKSEKETIMAHQPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQR 281
Query: 180 -PNSEGAASHTGDSSCPTSITQESSFGSPTGNQ-----------MSSDIDEYKKNIHGNA 227
NSE + S T Q G+ T + +S D + + H N+
Sbjct: 282 LDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVEDLLSQDENTLMDHQHSNS 341
Query: 228 LRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSEL 287
+ S S+V + S D + P SS S S + S GSS N+ SE+
Sbjct: 342 MDNLDSECSEVYQPLTSSD---------DALDAPSSSESEGIPSIERSRKGSSGNA-SEV 391
Query: 288 SLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQ 347
S+A LTE+I +MEEN HST+EELQATLQEL+D QQ+ QEL +ENE+L +EK IL S Q
Sbjct: 392 SVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSENERLGEEKVILMESLCQ 451
Query: 348 HRERAEQLSQENEKLMNLLQER----VKNEEPTTQEGKIIELEQKCTGILEQGRFEREKL 403
++ E S++ E +LL E V +E+ + G+ +ELEQ+ + E RFERE+L
Sbjct: 452 QSDKLEHFSRQIEYFRSLLDEHHISYVIDED--VKSGRYMELEQRYMDLAENARFEREQL 509
Query: 404 LNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTL 463
L +QQ L+ +L+ E++N+ A EMI LKE + + +E E+ +A TLEE + T+
Sbjct: 510 LGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATV 569
Query: 464 EGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQE 523
++E LK+ L+ EKQK E ++ + + ++Q++L+ R +K+ E + L+++
Sbjct: 570 ASDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQED 629
Query: 524 LLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKET 583
L + + +AKVE +Y +E Q E L+ T KL+ E + E DMKET
Sbjct: 630 LAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERSDMKET 689
Query: 584 IFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRF 643
IFELED+VEQHRAVKLH+N +IS+LE++V KL++QK D+ER++KTL ++++EE+ EWR+F
Sbjct: 690 IFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQF 749
Query: 644 QADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 690
QADLQTAVV+ANDIK EAQ+E+ +KR+L E +EKN +L KEL +++
Sbjct: 750 QADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELEEIK 796
Score = 42.7 bits (99), Expect = 0.001
Identities = 100/513 (19%), Positives = 190/513 (37%), Gaps = 66/513 (12%)
Query: 205 GSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSS 264
G+ + D+ + G T+G T S +P AS T E S+ +
Sbjct: 44 GTAASLSKTKSSDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPAMTTVENKSKISTG 103
Query: 265 TSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKM-------------EENHHSTAEELQ 311
T++ K S + S ++ L + + +K+ + + TA E
Sbjct: 104 TASSTKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQGANDMALAKRSRSRTATECD 163
Query: 312 ATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVK 371
+ + S + + A K+ D T+ +T + E L NE L ++ +
Sbjct: 164 VRMSK-SKSDNQISDRAALEAKVKDLLTLAKT------KDVEILHLRNE-LRDMRAQLGI 215
Query: 372 NEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQ-QQLTCSLRKVEEENQGALEMIKR 430
NE+ + + K E+E ++ Q + +L +++E+N E + +
Sbjct: 216 NEDHSEGDEK----------------SEKETIMAHQPTDVESTLLQLQEQNTAIREELNQ 259
Query: 431 LKEENEKLNEFL-----ELERHNNN---MMAKTLEECRVTLEGLKMENGSLKSHLQGEKQ 482
LK EN L + L LE+ +N + +T + G+L S ++G
Sbjct: 260 LKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEG--- 316
Query: 483 KATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVE 542
+ +VE E M D L+ C+E+ Q L ++ + SS ++
Sbjct: 317 --SAPGSVEDLLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGI 374
Query: 543 KDYSYLKEICDHQAEQLSRTSL--KLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLH 600
++ A ++S L ++ + + ++++ T+ EL D + + +
Sbjct: 375 PSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSE 434
Query: 601 NNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCE 660
N +L E + L +Q LE + E +R + + V+ D+K
Sbjct: 435 NERLGEEKVILMESLCQQSDKLE--------HFSRQIEYFRSLLDEHHISYVIDEDVKSG 486
Query: 661 AQQELRTVKRKLLEEEEKNARLQKE-LGDVQGH 692
EL L E NAR ++E L VQ H
Sbjct: 487 RYMELEQRYMDLAE----NARFEREQLLGVQQH 515
Score = 30.8 bits (68), Expect = 4.5
Identities = 46/198 (23%), Positives = 81/198 (40%), Gaps = 16/198 (8%)
Query: 85 LESQVRELLAEAKAKDSEINRLRSELKKYK-EKRTLNAEGTDALGPNVDGTSVSP---GD 140
LE+ V++L + + EI L L++ E R A+ A+ D S + GD
Sbjct: 714 LENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGD 773
Query: 141 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIY-LEHSPNSEGAASHTGDSSCPTSIT 199
+ + +EKN+ KEL +++ + + +Y ++ + AA G S T
Sbjct: 774 LKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSST 833
Query: 200 QESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPS 259
SS +PT + D +A + +++ + + LSP A +P
Sbjct: 834 --SSEPTPTVKTLIKSFD--------SASQVPNPAAAAIPRTPLSPSPMKTPPAAAVSPM 883
Query: 260 RPLSSTSNPFKSSKCSTA 277
+ S S P +SK TA
Sbjct: 884 Q-RHSISGPISTSKPLTA 900
>gi|224451080 cytospin A [Homo sapiens]
Length = 1117
Score = 421 bits (1083), Expect = e-118
Identities = 266/707 (37%), Positives = 410/707 (57%), Gaps = 43/707 (6%)
Query: 14 GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPS--- 70
G ++TKR+ +E S T R R R + +K S+ +N K R+ +
Sbjct: 103 GTASSTKRSTSTGNKESSSTRERLRERTR-LNQSKKLPSAGQGANDMALAKRSRSRTATE 161
Query: 71 -----TKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTD 125
+K K +N+ ++AALE++V++LL AK KD EI LR+EL+ + + +N + ++
Sbjct: 162 CDVRMSKSKSDNQISDRAALEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINEDHSE 221
Query: 126 ALGPNVDGTSVS--PGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHS---- 179
+ T ++ P D E + L+E+N ++EL+ L+ ENR+LK++L L S
Sbjct: 222 GDEKSEKETIMAHQPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQR 281
Query: 180 -PNSEGAASHTGDSSCPTSITQESSFGSPTGNQ-----------MSSDIDEYKKNIHGNA 227
NSE + S T Q G+ T + +S D + + H N+
Sbjct: 282 LDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVEDLLSQDENTLMDHQHSNS 341
Query: 228 LRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSEL 287
+ S S+V + S D + P SS S S + S GSS N+ SE+
Sbjct: 342 MDNLDSECSEVYQPLTSSD---------DALDAPSSSESEGIPSIERSRKGSSGNA-SEV 391
Query: 288 SLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQ 347
S+A LTE+I +MEEN HST+EELQATLQEL+D QQ+ QEL +ENE+L +EK IL S Q
Sbjct: 392 SVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSENERLGEEKVILMESLCQ 451
Query: 348 HRERAEQLSQENEKLMNLLQER----VKNEEPTTQEGKIIELEQKCTGILEQGRFEREKL 403
++ E S++ E +LL E V +E+ + G+ +ELEQ+ + E RFERE+L
Sbjct: 452 QSDKLEHFSRQIEYFRSLLDEHHISYVIDED--VKSGRYMELEQRYMDLAENARFEREQL 509
Query: 404 LNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTL 463
L +QQ L+ +L+ E++N+ A EMI LKE + + +E E+ +A TLEE + T+
Sbjct: 510 LGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATV 569
Query: 464 EGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQE 523
++E LK+ L+ EKQK E ++ + + ++Q++L+ R +K+ E + L+++
Sbjct: 570 ASDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQED 629
Query: 524 LLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKET 583
L + + +AKVE +Y +E Q E L+ T KL+ E + E DMKET
Sbjct: 630 LAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERSDMKET 689
Query: 584 IFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRF 643
IFELED+VEQHRAVKLH+N +IS+LE++V KL++QK D+ER++KTL ++++EE+ EWR+F
Sbjct: 690 IFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQF 749
Query: 644 QADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 690
QADLQTAVV+ANDIK EAQ+E+ +KR+L E +EKN +L KEL +++
Sbjct: 750 QADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELEEIK 796
Score = 42.7 bits (99), Expect = 0.001
Identities = 100/513 (19%), Positives = 190/513 (37%), Gaps = 66/513 (12%)
Query: 205 GSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSS 264
G+ + D+ + G T+G T S +P AS T E S+ +
Sbjct: 44 GTAASLSKTKSSDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPAMTTVENKSKISTG 103
Query: 265 TSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKM-------------EENHHSTAEELQ 311
T++ K S + S ++ L + + +K+ + + TA E
Sbjct: 104 TASSTKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQGANDMALAKRSRSRTATECD 163
Query: 312 ATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVK 371
+ + S + + A K+ D T+ +T + E L NE L ++ +
Sbjct: 164 VRMSK-SKSDNQISDRAALEAKVKDLLTLAKT------KDVEILHLRNE-LRDMRAQLGI 215
Query: 372 NEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQ-QQLTCSLRKVEEENQGALEMIKR 430
NE+ + + K E+E ++ Q + +L +++E+N E + +
Sbjct: 216 NEDHSEGDEK----------------SEKETIMAHQPTDVESTLLQLQEQNTAIREELNQ 259
Query: 431 LKEENEKLNEFL-----ELERHNNN---MMAKTLEECRVTLEGLKMENGSLKSHLQGEKQ 482
LK EN L + L LE+ +N + +T + G+L S ++G
Sbjct: 260 LKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEG--- 316
Query: 483 KATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVE 542
+ +VE E M D L+ C+E+ Q L ++ + SS ++
Sbjct: 317 --SAPGSVEDLLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGI 374
Query: 543 KDYSYLKEICDHQAEQLSRTSL--KLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLH 600
++ A ++S L ++ + + ++++ T+ EL D + + +
Sbjct: 375 PSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSE 434
Query: 601 NNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCE 660
N +L E + L +Q LE + E +R + + V+ D+K
Sbjct: 435 NERLGEEKVILMESLCQQSDKLE--------HFSRQIEYFRSLLDEHHISYVIDEDVKSG 486
Query: 661 AQQELRTVKRKLLEEEEKNARLQKE-LGDVQGH 692
EL L E NAR ++E L VQ H
Sbjct: 487 RYMELEQRYMDLAE----NARFEREQLLGVQQH 515
Score = 30.8 bits (68), Expect = 4.5
Identities = 46/198 (23%), Positives = 81/198 (40%), Gaps = 16/198 (8%)
Query: 85 LESQVRELLAEAKAKDSEINRLRSELKKYK-EKRTLNAEGTDALGPNVDGTSVSP---GD 140
LE+ V++L + + EI L L++ E R A+ A+ D S + GD
Sbjct: 714 LENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGD 773
Query: 141 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIY-LEHSPNSEGAASHTGDSSCPTSIT 199
+ + +EKN+ KEL +++ + + +Y ++ + AA G S T
Sbjct: 774 LKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSST 833
Query: 200 QESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPS 259
SS +PT + D +A + +++ + + LSP A +P
Sbjct: 834 --SSEPTPTVKTLIKSFD--------SASQVPNPAAAAIPRTPLSPSPMKTPPAAAVSPM 883
Query: 260 RPLSSTSNPFKSSKCSTA 277
+ S S P +SK TA
Sbjct: 884 Q-RHSISGPISTSKPLTA 900
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 102 bits (253), Expect = 2e-21
Identities = 135/639 (21%), Positives = 271/639 (42%), Gaps = 85/639 (13%)
Query: 75 QENEGGEKAA----LESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPN 130
Q + E+AA +E+ +L+ K K++ + +RS+L K +++ + E D L
Sbjct: 632 QNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME--DTLN-K 688
Query: 131 VDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTG 190
+ + + E L+ K K + + + + +EKL+ L+
Sbjct: 689 LQEAEIKVKELE----VLQAKCNEQTKVIDNFTSQLKATEEKLLDLD------------- 731
Query: 191 DSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDF 250
++ + SS G ++ ++ +K I + + SS KAS
Sbjct: 732 ------ALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESS----KAS-------- 773
Query: 251 EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEEL 310
IT E R L T+ S+ S E L L EK + E S +
Sbjct: 774 -SITRELQGRELKLTNLQENLSEVSQV----KETLEKELQILKEKFAEASEEAVSVQRSM 828
Query: 311 QATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERV 370
Q T+ +L +++ L+++ EKL + +E F + ER EQL + EKL N + E +
Sbjct: 829 QETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 888
Query: 371 K------------NEEPTTQEGKIIELEQKCTGILEQGRFEREKL----LNIQQQLTCSL 414
K N+E +E + EL+ K T E F ++ + + +Q +
Sbjct: 889 KMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAA 948
Query: 415 RKVEEENQGALEMIKRLKEENEKL----NEFLELERHNNNMMAKTLEECRVTLEGLKMEN 470
+K EEE + E+ ++L + +K+ N+ EL+ ++T + L+ L+
Sbjct: 949 KKHEEEKK---ELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1005
Query: 471 GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 530
+ L+G +++ + +++ E + + K A+ +D +++ ++ +E +
Sbjct: 1006 LDTEDKLKGAREE--NSGLLQELEELRKQADKAKAAQTAEDAMQI-MEQMTKEKTETLAS 1062
Query: 531 IKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKL---QEKASESDAEIKDMKETIFEL 587
++ AK++ + LKE E+L+++ L +K E EI+ +K+ +
Sbjct: 1063 LEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQK 1122
Query: 588 EDQVEQHRAVKLHNNQLISEL------ESSVIKLEEQKSDLERQLKTLTKQMKEETEEWR 641
Q+ A++ N +L EL +S KLEE++S L QL + K+ + ++
Sbjct: 1123 SQQLS---ALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDAD 1179
Query: 642 RFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNA 680
+A LQ ++ + + + E EL ++ ++ +NA
Sbjct: 1180 EEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENA 1218
Score = 84.0 bits (206), Expect = 5e-16
Identities = 146/715 (20%), Positives = 275/715 (38%), Gaps = 106/715 (14%)
Query: 17 TTTKRTGIPAPREFSVTVSRERSVPRGPS-NPRKSVSSPTSSNTPTPTKHLRTPSTKPKQ 75
TT + A R T S S+ R PS + S+SS SS + P++ T +
Sbjct: 286 TTPAKAKANAVRRVMATTSA--SLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRY 343
Query: 76 ENEGGEKAALESQVRE-------LLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALG 128
+ AL+ ++E LLAE + +E+ + S + + +++ L +G D
Sbjct: 344 ARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQ-- 401
Query: 129 PNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASH 188
+V M+ A + + L+ LEEE R +++ +E ++G
Sbjct: 402 -HVLELEAKMDQLRTMVEAADREKVEL---LNQLEEEKRKVEDLQFRVEEESITKGDLEV 457
Query: 189 TGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 248
S + E ++ E ++ + N + DV + S
Sbjct: 458 ATVSEKSRIMELEKDLALRV-----QEVAELRRRLESN------KPAGDVDMS-----LS 501
Query: 249 DFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAE 308
+ I++ ++ T + + + SL E EE H +
Sbjct: 502 LLQEISSLQEKLEVTRTDH------------------QREITSLKEHFGAREETHQKEIK 543
Query: 309 ELQATLQELSDQQQMVQ-ELTAENEKLVDE----KTILETSFHQHRERAEQLSQENEKLM 363
L ++LS + + ++ +L N++ D K+ LET+ H++ E+L K
Sbjct: 544 ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK-- 601
Query: 364 NLLQERVKNEEPTTQEGKI-IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQ 422
L E + E TQ K+ ++ + + + Q ER + L L KV +E +
Sbjct: 602 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE 661
Query: 423 GALEMIK---------RLKEENEKLNEFLELERH-------------------NNNMMAK 454
+LE I+ L E + LN+ E E N K
Sbjct: 662 NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLK 721
Query: 455 TLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLE 514
EE + L+ L+ + KS ++ +Q + A E+ + E+++ + ++A E
Sbjct: 722 ATEEKLLDLDALRKASSEGKSEMKKLRQ---QLEAAEKQIKHLEIEKNAESSKASSITRE 778
Query: 515 LSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESD 574
L EL+ L+ N + VS + +EK+ LKE K E + E+
Sbjct: 779 LQGRELKLTNLQEN--LSEVSQVKETLEKELQILKE--------------KFAEASEEAV 822
Query: 575 AEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK 634
+ + M+ET+ +L + EQ + +L L K E K + E QL ++++
Sbjct: 823 SVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE-KDEREEQLIKAKEKLE 881
Query: 635 EETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDV 689
+ E + D + + ND ++++ ++ KL + E + LQK + D+
Sbjct: 882 NDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 936
Score = 83.2 bits (204), Expect = 8e-16
Identities = 141/626 (22%), Positives = 273/626 (43%), Gaps = 102/626 (16%)
Query: 76 ENEGGEKAALESQVRELLAEAKAKD---SEINRLRSELKKYKEKRTLNAEGTDALGPNVD 132
+N + A E ++ +L A KA SE+ +LR +L+ EK+ + E + N +
Sbjct: 714 DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEA-AEKQIKHLE----IEKNAE 768
Query: 133 GTSVSPGDTEPMIRALEEKNKNFQKELSD-------LEEENRVLKEKLIYLEHSPNSEGA 185
+ S E ++ E K N Q+ LS+ LE+E ++LKEK + E
Sbjct: 769 SSKASSITRE--LQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFA----EASEEAV 822
Query: 186 ASHTGDSSCPTSITQ-ESSFGSPTGNQMSSDIDEYKKNIHGNA--LRTSGSSSSDVTKAS 242
+ + Q E F N +SSD+++ ++N+ R + KA
Sbjct: 823 SVQRSMQETVNKLHQKEEQF-----NMLSSDLEKLRENLADMEAKFREKDEREEQLIKAK 877
Query: 243 --LSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME 300
L D ++ ++ + S+ L+ ++ + + V EL L K+ K
Sbjct: 878 EKLENDIAEIMKMSGDNSSQ-LTKMNDELRLKE--------RDVEELQL-----KLTKAN 923
Query: 301 ENHHSTAEELQATLQELSDQQQMVQELTAENE---------KLVDEKTILETSFHQHRER 351
EN A LQ ++++++ + + Q+ A+ KL D + +ETS +Q +E
Sbjct: 924 EN----ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL 979
Query: 352 AEQLSQENEKLMNLLQERVKNEEPTT--QEGKIIELEQKCTGILEQ-----GRFEREKLL 404
+ + + +E ++N + T E K+ ++ +G+L++ + ++ K
Sbjct: 980 KARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAA 1039
Query: 405 NIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECR--VT 462
+ + ++ +E L ++ K+ N KL L+ + NN + L + + +T
Sbjct: 1040 QTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLT 1099
Query: 463 LEGLKMEN--GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNEL 520
+E KME +++ Q QK+ + SA+++ E+ ++ E L +R E S +L
Sbjct: 1100 VENQKMEEFRKEIETLKQAAAQKSQQLSALQE--ENVKLAEELGRSRDEVT----SHQKL 1153
Query: 521 RQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQA---EQLSRTSLKLQEKASESDAEI 577
+E N + LL +++ ++K+ + +A + +S TS L EK DAE+
Sbjct: 1154 EEERSVLNNQ------LLEMKKRESKFIKDADEEKASLQKSISITSALLTEK----DAEL 1203
Query: 578 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK--- 634
+ ++ + L E A LH+ ++ LES +KLE + +LE QLK +Q+
Sbjct: 1204 EKLRNEVTVLRG--ENASAKSLHS--VVQTLESDKVKLELKVKNLELQLKENKRQLSSSS 1259
Query: 635 -------EETEEWRRFQADLQTAVVV 653
+E E + Q D +V+V
Sbjct: 1260 GNTDTQADEDERAQESQIDFLNSVIV 1285
Score = 70.9 bits (172), Expect = 4e-12
Identities = 137/678 (20%), Positives = 267/678 (39%), Gaps = 105/678 (15%)
Query: 86 ESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGT--DALGPNVDGTSVSPGDTEP 143
+S++ EL + + E+ LR L+ K ++ + + + V+ D +
Sbjct: 463 KSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQR 522
Query: 144 MIRALEE----KNKNFQKELS-------DLEEENRVLKEKLIYLEHSPNSEGAASHTGDS 192
I +L+E + + QKE+ L +EN LK KL EH+ S
Sbjct: 523 EITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKL---EHANKENSDVIALWKS 579
Query: 193 SCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEH 252
T+I ++E K + L T + +++ K + D++H
Sbjct: 580 KLETAIASHQQA-----------MEELKVSF-SKGLGTETAEFAEL-KTQIEKMRLDYQH 626
Query: 253 ITAETPSRPLSSTSNPFKSSKCSTAG-SSPNSVSELSLASLTEKIQKMEENHHSTAEELQ 311
++ S + K + A E SL ++ K+ K E+ H E++
Sbjct: 627 EIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQH---LVEME 683
Query: 312 ATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQL---------SQENEKL 362
TL +L + + V+EL K ++ +++ Q + E+L S E +
Sbjct: 684 DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 743
Query: 363 MNLLQERVKNEEPTTQEGKIIELEQ-----KCTGILEQGRFEREKLLNIQQQLTCSLRKV 417
M L+++++ E ++ K +E+E+ K + I + + KL N+Q+ L+ + +V
Sbjct: 744 MKKLRQQLEAAE---KQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLS-EVSQV 799
Query: 418 EEENQGALEMIKRLKEE------------NEKLNEFLELERHNNNMMAKTLEECRVTLEG 465
+E + L+++K E E +N+ L + NM++ LE+ R L
Sbjct: 800 KETLEKELQILKEKFAEASEEAVSVQRSMQETVNK-LHQKEEQFNMLSSDLEKLRENLAD 858
Query: 466 LKM---ENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQ 522
++ E + L K+K E E S + L E L E EL+
Sbjct: 859 MEAKFREKDEREEQLIKAKEKL-ENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL 917
Query: 523 ELLKANGEI----KHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIK 578
+L KAN K + + K E+ + + + ++L R L++K S + +
Sbjct: 918 KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ 977
Query: 579 DMK----------------------ETIFELEDQVEQHRAVKLHNNQLISELESSVIKLE 616
++K +T+ + ED+++ R N+ L+ ELE + +
Sbjct: 978 ELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGARE---ENSGLLQELEELRKQAD 1034
Query: 617 EQKS--DLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTV------ 668
+ K+ E ++ + + KE+TE + QT + N++ + L+ V
Sbjct: 1035 KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKS 1094
Query: 669 KRKLLEEEEKNARLQKEL 686
K L E +K +KE+
Sbjct: 1095 KELLTVENQKMEEFRKEI 1112
Score = 60.1 bits (144), Expect = 7e-09
Identities = 121/591 (20%), Positives = 232/591 (39%), Gaps = 71/591 (12%)
Query: 42 RGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVREL-LAEAKAKD 100
R S+ KS K ++ + E+ E Q REL L +
Sbjct: 734 RKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENL 793
Query: 101 SEINRLRSELKK----YKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQ 156
SE+++++ L+K KEK +E ++ ++ T E L + +
Sbjct: 794 SEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLR 853
Query: 157 KELSDLE---EENRVLKEKLIYLEHSPNSEGAA--SHTGDSSCP-TSITQESSFGSPTGN 210
+ L+D+E E +E+LI + ++ A +GD+S T + E
Sbjct: 854 ENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVE 913
Query: 211 QMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFK 270
++ + K N + + L+ S + + S A E E R LS +
Sbjct: 914 ELQLKLT--KANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKEL-ERKLSDLEKKME 970
Query: 271 SS--KCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELT 328
+S +C + + + E +Q +++ T ++L+ +E S Q ++EL
Sbjct: 971 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1030
Query: 329 AENEKLVDEKTI---LETSFHQHRERAEQLS------QENEKLMN----LLQERVKNEEP 375
+ +K +T ++ +E+ E L+ Q N KL N L + +KN E
Sbjct: 1031 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE 1090
Query: 376 TTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEE- 434
+ +++ +E + +E+ R E E L Q + L ++EEN E + R ++E
Sbjct: 1091 LNKSKELLTVENQK---MEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1147
Query: 435 --NEKL--------NEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSH-------- 476
++KL N+ LE+++ + + EE + + + + L
Sbjct: 1148 TSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLR 1207
Query: 477 -----LQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEI 531
L+GE A +V QT ES +V+ LKV LEL E +++L ++G
Sbjct: 1208 NEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKN-----LELQLKENKRQLSSSSGNT 1262
Query: 532 KHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKE 582
+ ++D + + Q + L+ + LQ K + +++ M E
Sbjct: 1263 D------TQADED----ERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1303
Score = 30.0 bits (66), Expect = 7.7
Identities = 23/134 (17%), Positives = 60/134 (44%), Gaps = 4/134 (2%)
Query: 557 EQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLE 616
E L +++ +E D E ++ + + + ++ + ++Q + ELE+ + +L
Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLR 414
Query: 617 EQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEE 676
+R+ L Q++EE + Q ++ + D++ E K +++E E
Sbjct: 415 TMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSE----KSRIMELE 470
Query: 677 EKNARLQKELGDVQ 690
+ A +E+ +++
Sbjct: 471 KDLALRVQEVAELR 484
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 102 bits (253), Expect = 2e-21
Identities = 135/639 (21%), Positives = 271/639 (42%), Gaps = 85/639 (13%)
Query: 75 QENEGGEKAA----LESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPN 130
Q + E+AA +E+ +L+ K K++ + +RS+L K +++ + E D L
Sbjct: 667 QNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME--DTLN-K 723
Query: 131 VDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTG 190
+ + + E L+ K K + + + + +EKL+ L+
Sbjct: 724 LQEAEIKVKELE----VLQAKCNEQTKVIDNFTSQLKATEEKLLDLD------------- 766
Query: 191 DSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDF 250
++ + SS G ++ ++ +K I + + SS KAS
Sbjct: 767 ------ALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESS----KAS-------- 808
Query: 251 EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEEL 310
IT E R L T+ S+ S E L L EK + E S +
Sbjct: 809 -SITRELQGRELKLTNLQENLSEVSQV----KETLEKELQILKEKFAEASEEAVSVQRSM 863
Query: 311 QATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERV 370
Q T+ +L +++ L+++ EKL + +E F + ER EQL + EKL N + E +
Sbjct: 864 QETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 923
Query: 371 K------------NEEPTTQEGKIIELEQKCTGILEQGRFEREKL----LNIQQQLTCSL 414
K N+E +E + EL+ K T E F ++ + + +Q +
Sbjct: 924 KMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAA 983
Query: 415 RKVEEENQGALEMIKRLKEENEKL----NEFLELERHNNNMMAKTLEECRVTLEGLKMEN 470
+K EEE + E+ ++L + +K+ N+ EL+ ++T + L+ L+
Sbjct: 984 KKHEEEKK---ELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1040
Query: 471 GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 530
+ L+G +++ + +++ E + + K A+ +D +++ ++ +E +
Sbjct: 1041 LDTEDKLKGAREE--NSGLLQELEELRKQADKAKAAQTAEDAMQI-MEQMTKEKTETLAS 1097
Query: 531 IKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKL---QEKASESDAEIKDMKETIFEL 587
++ AK++ + LKE E+L+++ L +K E EI+ +K+ +
Sbjct: 1098 LEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQK 1157
Query: 588 EDQVEQHRAVKLHNNQLISEL------ESSVIKLEEQKSDLERQLKTLTKQMKEETEEWR 641
Q+ A++ N +L EL +S KLEE++S L QL + K+ + ++
Sbjct: 1158 SQQLS---ALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDAD 1214
Query: 642 RFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNA 680
+A LQ ++ + + + E EL ++ ++ +NA
Sbjct: 1215 EEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENA 1253
Score = 87.8 bits (216), Expect = 3e-17
Identities = 159/726 (21%), Positives = 288/726 (39%), Gaps = 93/726 (12%)
Query: 17 TTTKRTGIPAPREFSVTVSRERSVPRGPS-NPRKSVSSPTSSNTPTPTKHLRTPSTKPKQ 75
TT + A R T S S+ R PS + S+SS SS + P++ T +
Sbjct: 286 TTPAKAKANAVRRVMATTSA--SLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRY 343
Query: 76 ENEGGEKAALESQVRE-------LLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDA-- 126
+ AL+ ++E LLAE + +E+ + S + + +++ L +G D
Sbjct: 344 ARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHV 403
Query: 127 --LGPNVDG--TSVSPGDTEP--MIRALEEKNKNFQKELSDLEEENRVLK---EKLIYLE 177
L +D T V D E ++ LEE+ + + +L EE + K E LE
Sbjct: 404 LELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVE-DLQFRVEEESITKGDLETQTKLE 462
Query: 178 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSD 237
H+ E S + + + +E S I E +K++ ALR +
Sbjct: 463 HARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDL---ALRVQEVAELR 519
Query: 238 VTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQ 297
S P A D + + + + +SS + ++ + + SL E
Sbjct: 520 RRLESNKP-AGDVD--MSLSLLQEISSLQEKLEVTRTD---------HQREITSLKEHFG 567
Query: 298 KMEENHHSTAEELQATLQELSDQQQMVQ-ELTAENEKLVDE----KTILETSFHQHRERA 352
EE H + L ++LS + + ++ +L N++ D K+ LET+ H++
Sbjct: 568 AREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAM 627
Query: 353 EQLSQENEKLMNLLQERVKNEEPTTQEGKI-IELEQKCTGILEQGRFEREKLLNIQQQLT 411
E+L K L E + E TQ K+ ++ + + + Q ER + L
Sbjct: 628 EELKVSFSK--GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALR 685
Query: 412 CSLRKVEEENQGALEMIK---------RLKEENEKLNEFLELERH--------------- 447
L KV +E + +LE I+ L E + LN+ E E
Sbjct: 686 AKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQT 745
Query: 448 ----NNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEML 503
N K EE + L+ L+ + KS ++ +Q + A E+ + E+++
Sbjct: 746 KVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ---QLEAAEKQIKHLEIEKNA 802
Query: 504 KVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTS 563
+ ++A EL EL+ L+ N + VS + +EK+ LKE
Sbjct: 803 ESSKASSITRELQGRELKLTNLQEN--LSEVSQVKETLEKELQILKE------------- 847
Query: 564 LKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLE 623
K E + E+ + + M+ET+ +L + EQ + +L L K E K + E
Sbjct: 848 -KFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE-KDERE 905
Query: 624 RQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQ 683
QL ++++ + E + D + + ND ++++ ++ KL + E + LQ
Sbjct: 906 EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQ 965
Query: 684 KELGDV 689
K + D+
Sbjct: 966 KSIEDM 971
Score = 83.2 bits (204), Expect = 8e-16
Identities = 141/626 (22%), Positives = 273/626 (43%), Gaps = 102/626 (16%)
Query: 76 ENEGGEKAALESQVRELLAEAKAKD---SEINRLRSELKKYKEKRTLNAEGTDALGPNVD 132
+N + A E ++ +L A KA SE+ +LR +L+ EK+ + E + N +
Sbjct: 749 DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEA-AEKQIKHLE----IEKNAE 803
Query: 133 GTSVSPGDTEPMIRALEEKNKNFQKELSD-------LEEENRVLKEKLIYLEHSPNSEGA 185
+ S E ++ E K N Q+ LS+ LE+E ++LKEK + E
Sbjct: 804 SSKASSITRE--LQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFA----EASEEAV 857
Query: 186 ASHTGDSSCPTSITQ-ESSFGSPTGNQMSSDIDEYKKNIHGNA--LRTSGSSSSDVTKAS 242
+ + Q E F N +SSD+++ ++N+ R + KA
Sbjct: 858 SVQRSMQETVNKLHQKEEQF-----NMLSSDLEKLRENLADMEAKFREKDEREEQLIKAK 912
Query: 243 --LSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME 300
L D ++ ++ + S+ L+ ++ + + V EL L K+ K
Sbjct: 913 EKLENDIAEIMKMSGDNSSQ-LTKMNDELRLKE--------RDVEELQL-----KLTKAN 958
Query: 301 ENHHSTAEELQATLQELSDQQQMVQELTAENE---------KLVDEKTILETSFHQHRER 351
EN A LQ ++++++ + + Q+ A+ KL D + +ETS +Q +E
Sbjct: 959 EN----ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL 1014
Query: 352 AEQLSQENEKLMNLLQERVKNEEPTT--QEGKIIELEQKCTGILEQ-----GRFEREKLL 404
+ + + +E ++N + T E K+ ++ +G+L++ + ++ K
Sbjct: 1015 KARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAA 1074
Query: 405 NIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECR--VT 462
+ + ++ +E L ++ K+ N KL L+ + NN + L + + +T
Sbjct: 1075 QTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLT 1134
Query: 463 LEGLKMEN--GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNEL 520
+E KME +++ Q QK+ + SA+++ E+ ++ E L +R E S +L
Sbjct: 1135 VENQKMEEFRKEIETLKQAAAQKSQQLSALQE--ENVKLAEELGRSRDEVT----SHQKL 1188
Query: 521 RQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQA---EQLSRTSLKLQEKASESDAEI 577
+E N + LL +++ ++K+ + +A + +S TS L EK DAE+
Sbjct: 1189 EEERSVLNNQ------LLEMKKRESKFIKDADEEKASLQKSISITSALLTEK----DAEL 1238
Query: 578 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK--- 634
+ ++ + L E A LH+ ++ LES +KLE + +LE QLK +Q+
Sbjct: 1239 EKLRNEVTVLRG--ENASAKSLHS--VVQTLESDKVKLELKVKNLELQLKENKRQLSSSS 1294
Query: 635 -------EETEEWRRFQADLQTAVVV 653
+E E + Q D +V+V
Sbjct: 1295 GNTDTQADEDERAQESQIDFLNSVIV 1320
Score = 72.4 bits (176), Expect = 1e-12
Identities = 142/699 (20%), Positives = 277/699 (39%), Gaps = 107/699 (15%)
Query: 67 RTPSTKPKQENEGGEKAAL--ESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGT 124
+T + K ++E E A + +S++ EL + + E+ LR L+ K ++ +
Sbjct: 477 KTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLS 536
Query: 125 --DALGPNVDGTSVSPGDTEPMIRALEE----KNKNFQKELS-------DLEEENRVLKE 171
+ + V+ D + I +L+E + + QKE+ L +EN LK
Sbjct: 537 LLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKS 596
Query: 172 KLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTS 231
KL EH+ S T+I ++E K + L T
Sbjct: 597 KL---EHANKENSDVIALWKSKLETAIASHQQA-----------MEELKVSF-SKGLGTE 641
Query: 232 GSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAG-SSPNSVSELSLA 290
+ +++ K + D++H ++ S + K + A E SL
Sbjct: 642 TAEFAEL-KTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLE 700
Query: 291 SLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRE 350
++ K+ K E+ H E++ TL +L + + V+EL K ++ +++ Q +
Sbjct: 701 AIRSKLDKAEDQH---LVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA 757
Query: 351 RAEQL---------SQENEKLMNLLQERVKNEEPTTQEGKIIELEQ-----KCTGILEQG 396
E+L S E + M L+++++ E ++ K +E+E+ K + I +
Sbjct: 758 TEEKLLDLDALRKASSEGKSEMKKLRQQLEAAE---KQIKHLEIEKNAESSKASSITREL 814
Query: 397 RFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEE------------NEKLNEFLEL 444
+ KL N+Q+ L+ + +V+E + L+++K E E +N+ L
Sbjct: 815 QGRELKLTNLQENLS-EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNK-LHQ 872
Query: 445 ERHNNNMMAKTLEECRVTLEGLKM---ENGSLKSHLQGEKQKATEASAVEQTAESCEVQE 501
+ NM++ LE+ R L ++ E + L K+K E E S +
Sbjct: 873 KEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL-ENDIAEIMKMSGDNSS 931
Query: 502 MLKVARAEKDLLELSCNELRQELLKANGEI----KHVSSLLAKVEKDYSYLKEICDHQAE 557
L E L E EL+ +L KAN K + + K E+ + + + +
Sbjct: 932 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK 991
Query: 558 QLSRTSLKLQEKASESDAEIKDMK----------------------ETIFELEDQVEQHR 595
+L R L++K S + +++K +T+ + ED+++ R
Sbjct: 992 ELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAR 1051
Query: 596 AVKLHNNQLISELESSVIKLEEQKS--DLERQLKTLTKQMKEETEEWRRFQADLQTAVVV 653
N+ L+ ELE + ++ K+ E ++ + + KE+TE + QT +
Sbjct: 1052 E---ENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKL 1108
Query: 654 ANDIKCEAQQELRTV------KRKLLEEEEKNARLQKEL 686
N++ + L+ V K L E +K +KE+
Sbjct: 1109 QNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEI 1147
Score = 60.1 bits (144), Expect = 7e-09
Identities = 121/591 (20%), Positives = 232/591 (39%), Gaps = 71/591 (12%)
Query: 42 RGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVREL-LAEAKAKD 100
R S+ KS K ++ + E+ E Q REL L +
Sbjct: 769 RKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENL 828
Query: 101 SEINRLRSELKK----YKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQ 156
SE+++++ L+K KEK +E ++ ++ T E L + +
Sbjct: 829 SEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLR 888
Query: 157 KELSDLE---EENRVLKEKLIYLEHSPNSEGAA--SHTGDSSCP-TSITQESSFGSPTGN 210
+ L+D+E E +E+LI + ++ A +GD+S T + E
Sbjct: 889 ENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVE 948
Query: 211 QMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFK 270
++ + K N + + L+ S + + S A E E R LS +
Sbjct: 949 ELQLKLT--KANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKEL-ERKLSDLEKKME 1005
Query: 271 SS--KCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELT 328
+S +C + + + E +Q +++ T ++L+ +E S Q ++EL
Sbjct: 1006 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1065
Query: 329 AENEKLVDEKTI---LETSFHQHRERAEQLS------QENEKLMN----LLQERVKNEEP 375
+ +K +T ++ +E+ E L+ Q N KL N L + +KN E
Sbjct: 1066 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE 1125
Query: 376 TTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEE- 434
+ +++ +E + +E+ R E E L Q + L ++EEN E + R ++E
Sbjct: 1126 LNKSKELLTVENQK---MEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1182
Query: 435 --NEKL--------NEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSH-------- 476
++KL N+ LE+++ + + EE + + + + L
Sbjct: 1183 TSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLR 1242
Query: 477 -----LQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEI 531
L+GE A +V QT ES +V+ LKV LEL E +++L ++G
Sbjct: 1243 NEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKN-----LELQLKENKRQLSSSSGNT 1297
Query: 532 KHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKE 582
+ ++D + + Q + L+ + LQ K + +++ M E
Sbjct: 1298 D------TQADED----ERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
Score = 40.0 bits (92), Expect = 0.007
Identities = 27/137 (19%), Positives = 66/137 (48%), Gaps = 3/137 (2%)
Query: 557 EQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLE 616
E L +++ +E D E ++ + + + ++ + ++Q + ELE+ + +L
Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLR 414
Query: 617 EQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQE---LRTVKRKLL 673
+R+ L Q++EE + Q ++ + D++ + + E ++ +++ LL
Sbjct: 415 TMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLL 474
Query: 674 EEEEKNARLQKELGDVQ 690
E+ K +LQ+EL D +
Sbjct: 475 FEKTKADKLQRELEDTR 491
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 100 bits (250), Expect = 4e-21
Identities = 145/680 (21%), Positives = 290/680 (42%), Gaps = 94/680 (13%)
Query: 75 QENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGT 134
Q++ + ++ + ++L + KD +I L + L+K KE +L + + L +
Sbjct: 497 QQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA- 555
Query: 135 SVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSC 194
G+T ++ L+EKN Q++++ L E+ + E H E +
Sbjct: 556 --GEGETA-VLNQLQEKNHTLQEQVTQLTEKLKNQSES-----HKQAQENLHDQVQEQKA 607
Query: 195 PTSITQESSFGSPTG-NQMSSDIDEYKKNIHGNALRTSGSS----SSDVTKASLSPDASD 249
Q+ T N+++S ++E K+ + ++ + S++ K + D +
Sbjct: 608 HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQN 667
Query: 250 FEHI-TAETPSRPLSSTSNPF-------------KSSKCSTAGSSPNSVSE--LSLASLT 293
H+ TA+ + N K CS S E LSL T
Sbjct: 668 --HLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725
Query: 294 EK----IQKMEENHHSTAEELQATLQELSDQQQMVQEL----TAENEKLVDEKTILETSF 345
E+ I+K+E + + LQ+L Q+Q+ +L T +++L EK I+ ++
Sbjct: 726 EELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTR 785
Query: 346 HQHRERAEQLSQENEKLMNLLQERV---KNEEPTTQEGKIIELE-----QKCTGILEQGR 397
++++E L +KL +E+ ++ E +QE KI E Q L++ +
Sbjct: 786 LDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVK 845
Query: 398 FERE-----------KLLNIQQQLTCSLRKVEEENQ----GALEMIKRLKEENEKLNEFL 442
E+E KL + L S + E+ENQ L++ K KE +L +
Sbjct: 846 MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQM 905
Query: 443 ELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHL--------QGEKQKATEASAVEQTA 494
E + K+LE+ + LK+E S++ L Q EK++ + +
Sbjct: 906 ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK 965
Query: 495 ESCE--------VQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYS 546
+S E +Q LK+A +K LE N+L+Q+L +A E+ ++ ++ +Y
Sbjct: 966 QSSEQKKKQIEALQGELKIAVLQKTELE---NKLQQQLTQAAQELAAEKEKISVLQNNYE 1022
Query: 547 YLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLIS 606
+E +QL + + + ++K ++E + ++ + +R + N+LI
Sbjct: 1023 KSQETF----KQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1078
Query: 607 ELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADL---QTAVVVANDIKCEAQQ 663
EL+++ LE+ + E+QL+ K +++ +E + +L ++ + +IKC ++
Sbjct: 1079 ELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEK 1138
Query: 664 ELRTVKRKLLEEEEKNARLQ 683
E+ L EE K+ +L+
Sbjct: 1139 EITK-----LNEELKSHKLE 1153
Score = 93.2 bits (230), Expect = 7e-19
Identities = 135/618 (21%), Positives = 268/618 (43%), Gaps = 83/618 (13%)
Query: 87 SQVRELLAEAKAKDSEI-NRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMI 145
S++ E L E +E+ ++L ++++E++ L T L + D E ++
Sbjct: 463 SRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE-------AQNDLEQVL 515
Query: 146 RALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFG 205
R + +K++ Q +LE + KE + LE A G+ T++ +
Sbjct: 516 RQIGDKDQKIQ----NLEALLQKSKENISLLEKEREDLYAKIQAGEGE--TAVLNQLQEK 569
Query: 206 SPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSST 265
+ T + + + E KN + + + V + A+ ++ ET L+S
Sbjct: 570 NHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQ 629
Query: 266 SNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEE--NHHSTAEE-LQATLQELSDQQQ 322
N K K S + +EL L++ K + + NH TA+ LQ QEL+
Sbjct: 630 LNESKE-KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITT 688
Query: 323 MVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQ--ERVKNEEPTTQEG 380
+ ++TA+ + + + LE+ +++E+ L Q+ E+L ++ E E ++E
Sbjct: 689 QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ 748
Query: 381 KIIELEQK--CTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKR-------- 430
+ +L+Q+ LE E K L +++++ S R ++ ALE IK+
Sbjct: 749 ALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEE 808
Query: 431 ---LKEENEKLNEFLELERHN-NNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATE 486
LK++ E L++ +++ NN + T+ E L+ +KME +L + L K K ++
Sbjct: 809 KQILKQDFETLSQETKIQHEELNNRIQTTVTE----LQKVKMEKEALMTELSTVKDKLSK 864
Query: 487 ASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQEL-LKANGEIKHVSSLLAKVEKDY 545
S + ++S +E K A DL E +C EL+ +L ++ +K L +EK+
Sbjct: 865 VSDSLKNSKSEFEKENQKGKAAILDL-EKTCKELKHQLQVQMENTLKEQKELKKSLEKE- 922
Query: 546 SYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLI 605
+E + + E+ M+E + + ++ ++Q+
Sbjct: 923 ---------------------KEASHQLKLELNSMQEQLIQAQNTLKQNE---------- 951
Query: 606 SELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQEL 665
K E+Q +LK ++Q K++ E Q +L+ AV+ +++ + QQ+L
Sbjct: 952 --------KEEQQLQGNINELKQSSEQKKKQIEA---LQGELKIAVLQKTELENKLQQQL 1000
Query: 666 RTVKRKLLEEEEKNARLQ 683
++L E+EK + LQ
Sbjct: 1001 TQAAQELAAEKEKISVLQ 1018
Score = 85.1 bits (209), Expect = 2e-16
Identities = 147/683 (21%), Positives = 286/683 (41%), Gaps = 84/683 (12%)
Query: 64 KHLRTPSTKPKQENEGGEK---------AALESQVRELLAEAKAKDSEINRLRSELKKYK 114
KH GGE L +V++L A K + L+ EL+KY+
Sbjct: 58 KHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQ 117
Query: 115 EKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRV-LKEKL 173
+ A+ D L V +S E + + +N N K++ DL E+ L ++
Sbjct: 118 GLQQQEAK-PDGL---VTDSSAELQSLEQQLEEAQTENFNI-KQMKDLFEQKAAQLATEI 172
Query: 174 IYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGS 233
++ + E + + T +T+E N+ ++ I + K + L+ G
Sbjct: 173 ADIKSKYDEERSLREAAEQKV-TRLTEEL-------NKEATVIQDLKTEL----LQRPGI 220
Query: 234 SSSDVTKASLSPDASDFEHITAETP--SRPLSSTSNPFKSSKCSTAGSSPNSVSELS--- 288
V K L + +++T E S L +S S+ + SEL+
Sbjct: 221 EDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGP 280
Query: 289 --LASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAE-NEKLVDEKTILETSF 345
+A +++QK++ + + ++ Q + L ++Q +L + NE+ V +K I + +
Sbjct: 281 QEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNI-QATL 339
Query: 346 HQHRERAEQLSQE---NEKLMNLLQERVKNEEPTTQEGK--IIELEQKCTGI------LE 394
HQ +QL +E ++ + + + TQ+ K + E+E K + L+
Sbjct: 340 HQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQ 399
Query: 395 QGRFEREKL-LNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMA 453
Q R E+E+ L +Q ++ K+ E + E RLKE+ + +E L + +
Sbjct: 400 QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQ 459
Query: 454 KTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLL 513
L L+ + L+ L KQ+ E A++Q+ + K+ A+ DL
Sbjct: 460 LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTA-------KLREAQNDL- 511
Query: 514 ELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYL-KEICDHQAE------------QLS 560
++ +++ + +I+++ +LL K +++ S L KE D A+ QL
Sbjct: 512 ----EQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQ 567
Query: 561 RTSLKLQEKASESDAEIKDMKETIFE----LEDQVEQHRAVKLHNNQLISELESSVIKLE 616
+ LQE+ ++ ++K+ E+ + L DQV++ +A + LE+SV +L
Sbjct: 568 EKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELN 627
Query: 617 EQKSDLERQLKTLTKQMKEETEEWRRFQA-------DLQTAVVVANDIKCEAQQELRTVK 669
Q ++ + ++ L Q+K +TE +A DLQ + A + + QQEL +
Sbjct: 628 SQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKIT 687
Query: 670 RKLLEEEEKNARLQKELGDVQGH 692
+L + K Q+ ++ H
Sbjct: 688 TQLDQVTAKLQDKQEHCSQLESH 710
Score = 82.8 bits (203), Expect = 1e-15
Identities = 143/660 (21%), Positives = 270/660 (40%), Gaps = 84/660 (12%)
Query: 65 HLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGT 124
HL T + + + E + +Q+ ++ A+ + K ++L S LK+YKEK + T
Sbjct: 668 HLDTAQNALQDKQQ--ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725
Query: 125 DALGPNV-----DGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHS 179
+ L + D V + + +++ N EL E ++ EK I
Sbjct: 726 EELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV---- 781
Query: 180 PNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNI---HGNALRTSGSSSS 236
S S SI Q+ + + D + + H ++ +
Sbjct: 782 --SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVT 839
Query: 237 DVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKC-----STAGSSPNSVSELSLAS 291
++ K + +A E T + LS S+ K+SK + G + E +
Sbjct: 840 ELQKVKMEKEALMTELSTVKDK---LSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKE 896
Query: 292 LTEKIQKMEENHHSTAEELQATLQ-ELSDQQQMVQELTAENEKLVDEKTILETSFHQHRE 350
L ++Q EN +EL+ +L+ E Q+ EL + E+L+ + L+ + + ++
Sbjct: 897 LKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956
Query: 351 ------RAEQLSQENEKLMNLLQERVKNE--EPTTQEGKIIELEQKCTGILEQGRFEREK 402
+Q S++ +K + LQ +K + T E K L+Q+ T ++ E+EK
Sbjct: 957 LQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK---LQQQLTQAAQELAAEKEK 1013
Query: 403 LLNIQ----------QQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMM 452
+ +Q +QL E E + +K ++E+ E L R+
Sbjct: 1014 ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ 1073
Query: 453 AKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCE-VQEMLKVARAEKD 511
K ++E + L+ ++ + LQ E+ KA + E++ + E V E K+A E
Sbjct: 1074 NKLIQELKTAKATLEQDSAKKEQQLQ-ERCKALQDIQKEKSLKEKELVNEKSKLAEIE-- 1130
Query: 512 LLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKAS 571
E+ C + +E+ K N E+K S L + K+ + LK+ + L + L+LQ KA
Sbjct: 1131 --EIKCRQ-EKEITKLNEELK--SHKLESI-KEITNLKDA----KQLLIQQKLELQGKAD 1180
Query: 572 ESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTK 631
A ++ K L+DQV++ EL+ I E+++ L ++K
Sbjct: 1181 SLKAAVEQEKRNQQILKDQVKKEE----------EELKKEFI---EKEAKLHSEIKEKEV 1227
Query: 632 QMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQG 691
MK+ E +A L + N+ L TVK++ + + + L+K+ D++G
Sbjct: 1228 GMKKHEEN----EAKLTMQITALNE-------NLGTVKKEWQSSQRRVSELEKQTDDLRG 1276
Score = 75.1 bits (183), Expect = 2e-13
Identities = 121/635 (19%), Positives = 259/635 (40%), Gaps = 60/635 (9%)
Query: 78 EGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVS 137
E EK +++E L+E + K L++E K+ +++R + L ++
Sbjct: 366 ELSEKGEATQKLKEELSEVETK---YQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
Query: 138 PGDTEPMIRA----LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAAS----HT 189
+TE + L+E+ + ++L D E++ L+ KL LE + S H
Sbjct: 423 LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482
Query: 190 GDSSCPTSITQESSFGSPTGN--QMSSDIDEYKKNIHGNALRTSGSSSSDVT--KASLSP 245
D + Q++ S T + +D+++ LR G + +A L
Sbjct: 483 LDKTKQQHQEQQALQQSTTAKLREAQNDLEQ--------VLRQIGDKDQKIQNLEALLQK 534
Query: 246 DASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHS 305
+ + E + +++ + +++ E + LTEK++ E+H
Sbjct: 535 SKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQE-QVTQLTEKLKNQSESHKQ 593
Query: 306 TAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNL 365
E L +QE + Q+ E V+E L + ++ +E+ QL + + L
Sbjct: 594 AQENLHDQVQEQKAHLRAAQDRVLSLETSVNE---LNSQLNESKEKVSQLDIQIKAKTEL 650
Query: 366 LQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGAL 425
L T Q + L+ + E K+ Q+T K++++ +
Sbjct: 651 LLSA--EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA---KLQDKQEHCS 705
Query: 426 EMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKAT 485
++ LKE EK +L LE+ + + + +LE +K LQ ++Q T
Sbjct: 706 QLESHLKEYKEK---YLSLEQKTEELEGQIKKLEADSLE-VKASKEQALQDLQQQRQLNT 761
Query: 486 EASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDY 545
+ E+ K EK+++ + R +L K + ++ + L K E++
Sbjct: 762 DLEL--------RATELSKQLEMEKEIV----SSTRLDLQKKSEALESIKQKLTKQEEE- 808
Query: 546 SYLKEICDHQAEQLSR-TSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQL 604
K+I E LS+ T ++ +E + + ++++ E E + + VK +++
Sbjct: 809 ---KQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKV 865
Query: 605 ISELESSVIKLEEQKS-------DLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDI 657
L++S + E++ DLE+ K L Q++ + E + Q +L+ ++ +
Sbjct: 866 SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEA 925
Query: 658 KCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGH 692
+ + EL +++ +L++ + + +KE +QG+
Sbjct: 926 SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
Score = 53.1 bits (126), Expect = 9e-07
Identities = 99/523 (18%), Positives = 215/523 (41%), Gaps = 69/523 (13%)
Query: 66 LRTPSTKPKQENEGGEKAAL--ESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEG 123
L+ ++ ++EN+ G+ A L E +EL + + + + + ELKK EK E
Sbjct: 869 LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEK---EA 925
Query: 124 TDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSE 183
+ L ++ + ++ E++ + Q +++L++ + K+++ L+
Sbjct: 926 SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIA 985
Query: 184 GAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDV--TKA 241
++ +TQ + + ++S + Y+K+ T SD ++
Sbjct: 986 VLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKS-----QETFKQLQSDFYGRES 1040
Query: 242 SLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEE 301
L D + + + LS S++ + G+ + EL A T +E+
Sbjct: 1041 ELLATRQDLKSVEEK-----LSLAQEDLISNR-NQIGNQNKLIQELKTAKAT-----LEQ 1089
Query: 302 NHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEK 361
+ ++LQ + L D Q+ E + + ++LV+EK+ L E++ EK
Sbjct: 1090 DSAKKEQQLQERCKALQDIQK---EKSLKEKELVNEKSKL--------AEIEEIKCRQEK 1138
Query: 362 LMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEEN 421
+ L E +K+ + +E ++ T + + + ++ L +Q + VE+E
Sbjct: 1139 EITKLNEELKSHK--------LESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEK 1190
Query: 422 QGALEMIKRLKEENEKL-NEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGE 480
+ + ++K+E E+L EF+E E AK E +K + +K H + E
Sbjct: 1191 RNQQILKDQVKKEEEELKKEFIEKE-------AKLHSE-------IKEKEVGMKKHEENE 1236
Query: 481 KQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAK 540
+ + +A + E L + E + +EL ++ GEI + + +
Sbjct: 1237 AKLTMQITA---------LNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQN 1287
Query: 541 VEKDYSYLKEIC---DHQAEQLSRTSLKLQEKASESDAEIKDM 580
+ + L E C + + E+L L+LQ K + A ++++
Sbjct: 1288 NQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQEL 1330
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 98.6 bits (244), Expect = 2e-20
Identities = 144/644 (22%), Positives = 263/644 (40%), Gaps = 91/644 (14%)
Query: 79 GGEKAALESQVREL---------LAEAKAKDSEINR--LRSELKKYKEKRTLNAEGTDAL 127
GGE A V+E LAE++A+ + + L+++L++ + L + L
Sbjct: 325 GGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKD---L 381
Query: 128 GPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAAS 187
+ + D + L K +K+ + ++ N+ L EKL LE E AA
Sbjct: 382 AQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAAL 441
Query: 188 HTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSS-SSDVTKASLSPD 246
T D Q D+ + + + ++ SGS ++D + SL
Sbjct: 442 ETEDGEGL--------------QQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGL 487
Query: 247 ASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHST 306
+ TPS P S+ +S + G SP +LA + HS
Sbjct: 488 SGQ------RTPSPPRRSSPGRGRSPR---RGPSPACSDSSTLALI-----------HSA 527
Query: 307 AEELQATLQELSDQQQMVQELTAENEKLVD----EKTILETSFHQHRERAEQLSQENEKL 362
+ Q +Q++ + + Q+L K + E+ LE + R++ + Q +E
Sbjct: 528 LHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDA 587
Query: 363 MNLLQE-RVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEEN 421
+Q R NE + ++ + Q E+ R EREKL Q++L ++EEE
Sbjct: 588 QREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQ 647
Query: 422 QGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEK 481
+ A++ R++ E E+ + LE +++AK L E R L ++ L+
Sbjct: 648 EDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ------- 700
Query: 482 QKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKV 541
AE EV E L A A + LELS +LR E + +S+L +
Sbjct: 701 ------------AEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESL 748
Query: 542 EKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHN 601
+D L + E+ +++L+ +++ +E +A + + EQ R +L
Sbjct: 749 AQDKLDLNRLVAQLEEE--KSALQGRQRQAEQEATVA-----------REEQERLEELRL 795
Query: 602 NQLISE--LESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKC 659
Q ++ LE S+ E+ + LE+QL TL + + E+ + L +
Sbjct: 796 EQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARR 855
Query: 660 EAQQELRTVKRKLLEEE---EKNARLQKELGDVQGHGRVVTSRA 700
EAQ+++ ++R E+E +++A L +L + GR ++ A
Sbjct: 856 EAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEA 899
Score = 77.4 bits (189), Expect = 4e-14
Identities = 100/454 (22%), Positives = 195/454 (42%), Gaps = 63/454 (13%)
Query: 294 EKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 353
E +++ + A+E +L ++ + L+ E +L EK LE S + + +
Sbjct: 862 EALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLA 921
Query: 354 QLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFERE----KLLNIQQQ 409
QL E+L Q + +E T G++ L Q+ E+ ++E KL+ +++
Sbjct: 922 QLEARREQLEAEGQALLLAKETLT--GELAGLRQQIIATQEKASLDKELMAQKLVQAERE 979
Query: 410 LTCSLRKVEEENQGALEMIKRLKE------ENEKLNEFLELERHNNNMMAKT---LEECR 460
SLR+ ++ L+ ++R KE E E+ +L+R ++A+ EE
Sbjct: 980 AQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELS 1039
Query: 461 VTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAES--------------CEVQEMLKVA 506
+ L+ E + EKQ+A E+TA S E++ + A
Sbjct: 1040 EEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDA 1099
Query: 507 RAEKDLLELSCNELRQEL--LKANGE---IKHVSSL--LAKVEKDYSYLKEICDHQAEQL 559
++ ++ + N L EL L+A E H + L + +D ++ C +AE+L
Sbjct: 1100 QSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEEL 1159
Query: 560 SRTSLKLQEKASES-------------------DAEIKDMKETIFELEDQVEQHRAVKLH 600
RT L+L E A + + + ++ E L + ++ A++
Sbjct: 1160 -RTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRS 1218
Query: 601 NNQL---ISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDI 657
N +L + + ES I L+ D E++L L + +E +L+T +
Sbjct: 1219 NEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKE----AGELRTGLQEVERS 1274
Query: 658 KCEAQQELRTVKRKLLEEEEKNARLQKELGDVQG 691
+ EA++EL+ ++R++ + +N RL +EL ++QG
Sbjct: 1275 RLEARRELQELRRQMKMLDSENTRLGRELAELQG 1308
Score = 70.1 bits (170), Expect = 7e-12
Identities = 101/495 (20%), Positives = 195/495 (39%), Gaps = 68/495 (13%)
Query: 251 EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEE- 309
E +A + +R L + ++ S G +EL+L E +++ E +T ++
Sbjct: 1545 ERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQE--ESVRRSERERRATLDQV 1602
Query: 310 ------LQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLM 363
LQAT EL Q+ + ++ A KL +K L+ R +L + L
Sbjct: 1603 ATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLE 1662
Query: 364 NLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQ---QQLTCSLRKVEEE 420
LQ + +E + L+ + + Q K +Q ++L +L KVEE
Sbjct: 1663 GELQR--SRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEES 1720
Query: 421 NQGALEMIKRLKE--------------ENEKLNEFLELERHNNNMMAKTLEECRVTLEGL 466
+ ++ L E +N L + L H+ ++ + L+ R L
Sbjct: 1721 EGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEA 1780
Query: 467 KMENGSLKSHLQ-----------------GEKQKATEASAVEQTAESCEVQEMLKVARAE 509
+ ++ SL +Q G+ Q+ E Q E+ + + K+ + E
Sbjct: 1781 RKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKL-QDE 1839
Query: 510 KDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEK 569
+ LL+ L++ L + E + V ++EKD L+ D ++ R L+ E
Sbjct: 1840 RRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLD----KVEREKLRSHED 1895
Query: 570 ASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTL 629
AE + T+ E ++ + + + I +LE+ V+ LE+ S + ++
Sbjct: 1896 TVRLSAEKGRLDRTLTGAELELAEAQ-------RQIQQLEAQVVVLEQSHSPAQLEVDAQ 1948
Query: 630 TKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDV 689
+Q++ + E R A QT + EA++ + + LEE+ + G +
Sbjct: 1949 QQQLELQQEVERLRSAQAQT------ERTLEARERAHRQRVRGLEEQVSTLK-----GQL 1997
Query: 690 QGHGRVVTSRAAPPS 704
Q R ++ +PPS
Sbjct: 1998 QQELRRSSAPFSPPS 2012
Score = 69.3 bits (168), Expect = 1e-11
Identities = 143/729 (19%), Positives = 276/729 (37%), Gaps = 85/729 (11%)
Query: 36 RERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAE 95
R S R PS PR+S S P+ ST + ++ + QV+++
Sbjct: 485 RGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKR---QLQVQDMRGR 541
Query: 96 AKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNF 155
+A + LR +L + +R E L DG + D + ++ L N+
Sbjct: 542 YEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELL 601
Query: 156 QKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSD 215
+E S+L +V +++ L AA + +E G ++ +
Sbjct: 602 SREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQ-RDRLEEEQEDAVQDGARVRRE 660
Query: 216 ID---------EYKKNIHGNAL------RTSGSSSSDVTKASLSPDASDFEHITAETPSR 260
++ E K+++ L + + D+ +A + A A
Sbjct: 661 LERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVEL 720
Query: 261 PLSSTSNPFKSSKCSTAGSSPNSVSE------LSLASLTEKI----------QKMEENHH 304
LS T + + + S ++++E L L L ++ Q+ E
Sbjct: 721 ELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEA 780
Query: 305 STAEELQATLQELSDQQQMVQELTAENEKLVDE-KTILETSFHQHRERAEQLSQENEKLM 363
+ A E Q L+EL +Q++ ++ + ++ ++ + LE R QL ++ +L
Sbjct: 781 TVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLS 840
Query: 364 NLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQG 423
L R + E +E Q+ LE+ E+E L L L E E +
Sbjct: 841 RQLSGREQELEQARREA------QRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRT 894
Query: 424 ALEMIKRLKEENEKL-NEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQ 482
E RL+ E E L E++R + A+ E+ + L + +L L G +Q
Sbjct: 895 LSEEATRLRLEKEALEGSLFEVQRQLAQLEARR-EQLEAEGQALLLAKETLTGELAGLRQ 953
Query: 483 KA----------TEASAVEQTAESCEVQEMLKVARA--EKDL------LELSCNELRQEL 524
+ E A + E Q L+ RA E+DL E + EL E
Sbjct: 954 QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013
Query: 525 LKANGEI-KHVSSLLAKVEKDYSYLKE------------ICDHQAEQLSRTSLKLQEKAS 571
+ ++ + LLA++E + L E + ++E+ SLK EK +
Sbjct: 1014 AQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTA 1073
Query: 572 ESDAEI---KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLE----- 623
S+ + + E+E Q ++ + + ++ L S + L Q+ +
Sbjct: 1074 LSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQ 1133
Query: 624 --RQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNAR 681
R+L+ + + ++ + R +L+T + + D + ++EL +RKL E +E
Sbjct: 1134 EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREV 1193
Query: 682 LQKELGDVQ 690
++E G+++
Sbjct: 1194 QRQEAGELR 1202
Score = 65.5 bits (158), Expect = 2e-10
Identities = 128/650 (19%), Positives = 248/650 (38%), Gaps = 63/650 (9%)
Query: 81 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 140
E++ L+ Q+ +L + ++ E+ + R E ++ E A +AL G +V
Sbjct: 828 ERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVA 887
Query: 141 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLE---HSPNSEGAASHTGDSSCPTS 197
E R L E+ + E LE ++ +L LE +EG A
Sbjct: 888 AEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQA---------LL 938
Query: 198 ITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAET 257
+ +E+ G G + + K ++ + + +ASL + E +
Sbjct: 939 LAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEE-DLQR 997
Query: 258 PSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQEL 317
R + ++ + EL EK + EE E + L
Sbjct: 998 LQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE 1057
Query: 318 SDQQQMVQ----ELTAENEKLVDEKTILET-SFHQHRER--AEQLSQENEKLMNLLQERV 370
S++QQ + E TA +EKL+ + L T S R++ A+ +++ +N L +
Sbjct: 1058 SEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSEL 1117
Query: 371 KNEEPTTQEGKIIELEQKCTGILEQGRF---EREKLLNIQQQLTCSLRKVEEENQGALEM 427
++ +E Q+ + EQ R +R+ L ++L LR +E+ G
Sbjct: 1118 RDLRAQREEAAAAHA-QEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRE 1176
Query: 428 IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEA 487
+ + + + E E++R + ++L E E L+ N L+S ++
Sbjct: 1177 LLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVK--------- 1227
Query: 488 SAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSY 547
AES + LK+A +K+ E R + K GE++ +
Sbjct: 1228 -----KAESERIS--LKLANEDKEQKLALLEEARTAVGKEAGELR-------------TG 1267
Query: 548 LKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISE 607
L+E+ + + R +L+ + D+E + + EL+ ++ + + +
Sbjct: 1268 LQEV-ERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLG 1326
Query: 608 LESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRT 667
L ++K E + ++L+ ++++E+ E+R + L ++ A + + R
Sbjct: 1327 LRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARG 1386
Query: 668 VKRKL----LEEEEKNARLQKELGDVQG----HGRV-VTSRAAPPSLGSV 708
++ KL E E RL G QG RV V RAA LG +
Sbjct: 1387 LELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGL 1436
Score = 41.2 bits (95), Expect = 0.003
Identities = 40/200 (20%), Positives = 91/200 (45%), Gaps = 6/200 (3%)
Query: 498 EVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAE 557
E + L+ A+ E+D L + L ++L + E +S +++K + +E
Sbjct: 1513 EFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDG 1572
Query: 558 QLSRTSLKL---QEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIK 614
+LS +L +E S+ E + + + LE ++ + + + IS+++++ K
Sbjct: 1573 RLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETK 1632
Query: 615 LEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEA---QQELRTVKRK 671
LE K L+ L + + + R + +LQ + + +D + +A Q + +++R+
Sbjct: 1633 LEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQ 1692
Query: 672 LLEEEEKNARLQKELGDVQG 691
+ + E K LQ + + G
Sbjct: 1693 VADSEVKAGTLQLTVERLNG 1712
Score = 37.7 bits (86), Expect = 0.037
Identities = 51/282 (18%), Positives = 112/282 (39%), Gaps = 32/282 (11%)
Query: 365 LLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGA 424
L QE+ Q+ +I L I+ + + E + + SL ++EENQ
Sbjct: 27 LCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPESPVLLPATEMASLLSLQEENQ-- 84
Query: 425 LEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLE-GLKMENGSLKSHLQGEKQK 483
L++E ++ + L R + +A LE L++E G L++
Sbjct: 85 -----LLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQ------- 132
Query: 484 ATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEK 543
E + + +S E++ L+ +A R++L + + L+ +++
Sbjct: 133 --EPRGLVR--QSVELRRQLQEEQAS----------YRRKLQAYQEGQQRQAQLVQRLQG 178
Query: 544 DYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQ 603
K+ C +QL S +L+++ +D++ + LE++ ++ ++ N
Sbjct: 179 KILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAM 238
Query: 604 LISELESSVIKLEEQKSDLERQLKTLT---KQMKEETEEWRR 642
L +L+ + + D+ + T K+++ WRR
Sbjct: 239 LREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRR 280
Score = 35.8 bits (81), Expect = 0.14
Identities = 30/158 (18%), Positives = 74/158 (46%), Gaps = 26/158 (16%)
Query: 495 ESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDH 554
E V+++L +RAE+D L + N + + L +A ++E E+
Sbjct: 89 ELSRVEDLLAQSRAERDELAIKYNAVSERLEQA-----------LRLEPG-----ELETQ 132
Query: 555 QAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIK 614
+ L R S++L+ + E A + +++ ++ + QL+ L+ +++
Sbjct: 133 EPRGLVRQSVELRRQLQEEQASYRR----------KLQAYQEGQQRQAQLVQRLQGKILQ 182
Query: 615 LEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVV 652
+++ S+LE+QL + +++++ DL++A++
Sbjct: 183 YKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI 220
Score = 34.3 bits (77), Expect = 0.41
Identities = 25/90 (27%), Positives = 44/90 (48%), Gaps = 7/90 (7%)
Query: 84 ALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEP 143
+L+ QV + +A + RL L K +E +EG AL V G + + +
Sbjct: 1688 SLQRQVADSEVKAGTLQLTVERLNGALAKVEE-----SEG--ALRDKVRGLTEALAQSSA 1740
Query: 144 MIRALEEKNKNFQKELSDLEEENRVLKEKL 173
+ + +KN + QK L+ E + +VL+E+L
Sbjct: 1741 SLNSTRDKNLHLQKALTACEHDRQVLQERL 1770
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 96.3 bits (238), Expect = 9e-20
Identities = 135/613 (22%), Positives = 249/613 (40%), Gaps = 95/613 (15%)
Query: 140 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN-------SEGAASHTGDS 192
+TE + ++E+ + + EL+ E + + L+EK++ L N SE + +
Sbjct: 847 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEE 906
Query: 193 SCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEH 252
C I + + ++ + ++ NA T+ + + L D D E
Sbjct: 907 RCEQLIKNKIQLEA----KIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLEL 962
Query: 253 ITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQA 312
A+ + K +T N E +A L E I K+ + + E Q
Sbjct: 963 TLAKV------------EKEKHATENKVKNLTEE--MAGLDETIAKLSKEKKALQETHQQ 1008
Query: 313 TLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL---MNLLQER 369
TL +L ++ V LT KL + LE S Q ++ L + KL + L QE
Sbjct: 1009 TLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1068
Query: 370 VKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIK 429
+ E Q +L++K LE+ FE L++ K+E+E +++ K
Sbjct: 1069 TMDMENDKQ-----QLDEK----LEKKEFEISNLIS----------KIEDEQAVEIQLQK 1109
Query: 430 RLKE---ENEKLNEFLELER-------HNNNMMAKTLEECRVTLEGLKMENGSLKSHLQG 479
++KE E+L E +E ER + +++ LEE E L+ G+ + ++
Sbjct: 1110 KIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEIS---ERLEEAGGATSAQVEL 1166
Query: 480 EKQKATEASAVEQTAESCEVQEMLKVARAEK----DLLEL-----SCNELRQELLKANGE 530
K++ E + + E +Q VA K + EL + ++Q+L K E
Sbjct: 1167 NKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSE 1226
Query: 531 IK----HVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFE 586
+K +SS + K L+++C +Q+S +L+ K E I D+
Sbjct: 1227 LKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVS----ELKTKEEEQQRLINDLTAQRAR 1282
Query: 587 LEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ-------------- 632
L+ + ++ + L+S+L S +Q +L+ QL+ TK
Sbjct: 1283 LQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHD 1342
Query: 633 ---MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEE-EEKNARLQKELGD 688
++E+ EE + +A+LQ A+ AN + + + T + EE EE +L + L +
Sbjct: 1343 CDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE 1402
Query: 689 VQGHGRVVTSRAA 701
+ H V ++ A
Sbjct: 1403 AEEHVEAVNAKCA 1415
Score = 80.9 bits (198), Expect = 4e-15
Identities = 134/632 (21%), Positives = 248/632 (39%), Gaps = 51/632 (8%)
Query: 81 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 140
EK A E++V+ L E D I +L E K +E + A V+ + +
Sbjct: 970 EKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTK 1029
Query: 141 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQ 200
E + LE + +K DLE R L+ L + S D +
Sbjct: 1030 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFE 1089
Query: 201 ESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSR 260
S+ S ++ + +I KK A + +AS + + SR
Sbjct: 1090 ISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDL-----SR 1144
Query: 261 PLSSTSNPFKSSKCSTAGSSP-NSVSELSLASLTEKIQKMEENHHSTAEELQAT-LQELS 318
L S + + +T+ N E L +++ H + L+ ++
Sbjct: 1145 ELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMA 1204
Query: 319 DQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQEN---EKLMNLLQERVKNEEP 375
+ + + L +KL EK+ L+ AE +S+ EK+ L+++V +
Sbjct: 1205 ELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKT 1264
Query: 376 TTQEGKIIELE---QKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLK 432
+E + + + Q+ E G + R+ L+ + L L + ++ + +E +K
Sbjct: 1265 KEEEQQRLINDLTAQRARLQTEAGEYSRQ--LDEKDALVSQLSRSKQASTQQIEELKHQL 1322
Query: 433 EENEK----LNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEAS 488
EE K L L+ RH+ +++ + EE + EG K+ LQ KA
Sbjct: 1323 EEETKAKNALAHALQSSRHDCDLLREQYEEEQ---EG--------KAELQRALSKANSEV 1371
Query: 489 AVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYL 548
A +T + + R E+ LE + +L Q L +A ++ V++ A +EK L
Sbjct: 1372 AQWRTKYETDA-----IQRTEE--LEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRL 1424
Query: 549 KEICDH---QAEQLSRTSLKLQEKASESDAEIKDMK----ETIFELEDQVEQHRAVKLHN 601
+ + E+ + L +K D + + K ET ELE ++ R++
Sbjct: 1425 QNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTEL 1484
Query: 602 NQLISELESSVIKLE---EQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIK 658
++ + E S+ +LE + +L++++ LT+Q+ E ++ +L+ K
Sbjct: 1485 FKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIH----ELEKIKKQVEQEK 1540
Query: 659 CEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 690
CE Q L + L EE K R+Q EL V+
Sbjct: 1541 CEIQAALEEAEASLEHEEGKILRIQLELNQVK 1572
Score = 73.9 bits (180), Expect = 5e-13
Identities = 87/432 (20%), Positives = 177/432 (40%), Gaps = 62/432 (14%)
Query: 295 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 354
K + E+ + EE Q T EL+ + +EL + L+ EK L+ +
Sbjct: 844 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLAD 903
Query: 355 LSQENEKLM-NLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCS 413
+ E+L+ N +Q K +E T + + E+ + T + E +L L +
Sbjct: 904 AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELT 963
Query: 414 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 473
L KVE+E +K L EE L+E + + +T ++ TL+ L+ E +
Sbjct: 964 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQ---TLDDLQAEEDKV 1020
Query: 474 KSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKH 533
K K V+ S E ++ L++ +L + K G++K
Sbjct: 1021 NILT---KAKTKLEQQVDDLEGSLEQEKKLRM-------------DLERAKRKLEGDLKL 1064
Query: 534 VSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKAS---ESDAEIKDMKETIFELEDQ 590
+E D L E + + ++S K++++ + + +IK+++ I EL ++
Sbjct: 1065 AQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEE 1124
Query: 591 VEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQM--------------KEE 636
+E RA S K E+Q+SDL R+L+ +++++ K+
Sbjct: 1125 IEAERA--------------SRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKR 1170
Query: 637 TEEWRRFQADLQTAVVVAN-----------DIKCEAQQELRTVKRKLLEEEEKNARLQKE 685
E+++ + DL+ A + D E +++ ++R + E++ + L+ E
Sbjct: 1171 EAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKME 1230
Query: 686 LGDVQGHGRVVT 697
D+ + ++
Sbjct: 1231 TDDLSSNAEAIS 1242
Score = 73.9 bits (180), Expect = 5e-13
Identities = 152/674 (22%), Positives = 278/674 (41%), Gaps = 102/674 (15%)
Query: 84 ALESQVRELLAEAKAKDSEINRL---RSELKKYKEKRTLNAEGTDALGPNVDGTS-VSPG 139
+LE QV EL + + + IN L R+ L+ + + + DAL + + S
Sbjct: 1254 SLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQ 1313
Query: 140 DTEPMIRALEEKNKN-------FQKELSDLE------EENRVLKEKLIYLEHSPNSEGAA 186
E + LEE+ K Q D + EE + K +L NSE A
Sbjct: 1314 QIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQ 1373
Query: 187 SHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNAL---RTSGSSSSDVTKASL 243
T + T+E Q + +E+ + ++ +T ++V L
Sbjct: 1374 WRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1433
Query: 244 SPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENH 303
+ S+ + R + +K T S E SL+ ++ K++ +
Sbjct: 1434 DVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESR--SLSTELFKVKNVY 1491
Query: 304 HSTAEELQATLQELSDQQQMVQELT---AENEKLVDEKTILETSFHQHRERAEQLSQENE 360
+ ++L+ +E + QQ + +LT AE K + H+ + +Q+ QE
Sbjct: 1492 EESLDQLETLRRENKNLQQEISDLTEQIAEGGKQI----------HELEKIKKQVEQEKC 1541
Query: 361 KLMNLLQERVKNEEPTTQEGKIIELEQKCTGIL-EQGRFEREKLLNIQQQLTCSLRKVEE 419
++ L+E + E +EGKI+ ++ + + E R EK I Q R VE
Sbjct: 1542 EIQAALEEAEASLEH--EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVET 1599
Query: 420 -------ENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGS 472
E + + ++ K+ LNE H N + A++L R T LK
Sbjct: 1600 MQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLH 1659
Query: 473 LKSHLQGEKQKATEASAVEQTAE--SCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 530
L L+G++ + + VE+ A E++E+ A + E S QELL A+
Sbjct: 1660 LDDALRGQEDLKEQLAIVERRANLLQAEIEELW----ATLEQTERSRKIAEQELLDASER 1715
Query: 531 IKHV----SSLL---AKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASE--SDAEI---- 577
++ + +SL+ K+E D S L+ + E++ + S +EKA + +DA +
Sbjct: 1716 VQLLHTQNTSLINTKKKLENDVSQLQS----EVEEVIQESRNAEEKAKKAITDAAMMAEE 1771
Query: 578 ---------------KDMKETIFELEDQVEQHRAVKLH-NNQLISELESSVIKLE----- 616
K++++T+ +L+ ++++ + L + I +LE+ V +LE
Sbjct: 1772 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVEN 1831
Query: 617 EQKSDLE-----RQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRK 671
EQK + E R+ + K++ +TEE R+ LQ D+ + Q ++++ KR+
Sbjct: 1832 EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQ-------DLVDKLQAKVKSYKRQ 1884
Query: 672 LLE-EEEKNARLQK 684
E EE+ NA L K
Sbjct: 1885 AEEAEEQSNANLSK 1898
Score = 68.6 bits (166), Expect = 2e-11
Identities = 122/613 (19%), Positives = 243/613 (39%), Gaps = 101/613 (16%)
Query: 74 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 133
K E+E + L+ +++EL A + EI R+ K +++R+ + + + ++
Sbjct: 1096 KIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1155
Query: 134 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS 193
G T + +++ FQK DLEE L+H DS
Sbjct: 1156 AG---GATSAQVELNKKREAEFQKLRRDLEEAT---------LQHEAMVAALRKKHADSM 1203
Query: 194 CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI 253
++ ID ++ K L + S+ +
Sbjct: 1204 A----------------ELGEQIDNLQR-----------------VKQKLEKEKSELKME 1230
Query: 254 TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT 313
T + LSS + +K + E SL +++ +++ EE Q
Sbjct: 1231 TDD-----LSSNAEAISKAKGNL---------EKMCRSLEDQVSELKTKE----EEQQRL 1272
Query: 314 LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE 373
+ +L+ Q+ +Q E + +DEK L + + ++ + +Q+ E+L + L+E K +
Sbjct: 1273 INDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAS---TQQIEELKHQLEEETKAK 1329
Query: 374 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 433
+ C + EQ E+E +Q+ L+ + +V + R K
Sbjct: 1330 NALAHA--LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQW---------RTKY 1378
Query: 434 ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASA-VEQ 492
E + + ELE + A+ L+E +E + + SL+ Q + + + VE+
Sbjct: 1379 ETDAIQRTEELEEAKKKL-AQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER 1437
Query: 493 TAESCEVQEMLKVARAEKDLLELS--CNELRQELLKANGEIKHVSSLLAKVEKDYSYLKE 550
+ +C + K +K L E E + EL + E + +S+ L KV+ Y +E
Sbjct: 1438 SNAACAALDK-KQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVY---EE 1493
Query: 551 ICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELES 610
D Q E L R + LQ++ S+ +I + + I ELE +Q K + E E+
Sbjct: 1494 SLD-QLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEA 1552
Query: 611 SV-----------IKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKC 659
S+ ++L + KS+++R++ + EE ++ +R + + D +
Sbjct: 1553 SLEHEEGKILRIQLELNQVKSEVDRKI----AEKDEEIDQLKRNHTRVVETMQSTLDAEI 1608
Query: 660 EAQQELRTVKRKL 672
++ + VK+K+
Sbjct: 1609 RSRNDALRVKKKM 1621
Score = 51.6 bits (122), Expect = 2e-06
Identities = 115/599 (19%), Positives = 223/599 (37%), Gaps = 68/599 (11%)
Query: 43 GPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEA-KAKDS 101
G + ++++S S TK+ + ++ E +K A Q E EA AK +
Sbjct: 1356 GKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCA 1415
Query: 102 EINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSD 161
+ + + L+ E L+ E ++A AL++K +NF K LS+
Sbjct: 1416 SLEKTKQRLQNEVEDLMLDVERSNAA-----------------CAALDKKQRNFDKVLSE 1458
Query: 162 LEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGN--QMSSDIDEY 219
+++ + +L + S + S+ Q + N Q SD+ E
Sbjct: 1459 WKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQ 1518
Query: 220 KKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS 279
+ G ++ K + E I A S K + +
Sbjct: 1519 --------IAEGGKQIHELEKIKKQVEQEKCE-IQAALEEAEASLEHEEGKILRIQLELN 1569
Query: 280 SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQE--------LSDQQQMVQELTAEN 331
S + +A E+I +++ NH E +Q+TL L +++M +L
Sbjct: 1570 QVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEME 1629
Query: 332 EKLVDEKTILETSFHQHRERAEQLSQENEKLMNLL--QERVKNEEPTTQE-GKIIELE-Q 387
+L + S +R L + L + L QE +K + + +++ E +
Sbjct: 1630 IQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIE 1689
Query: 388 KCTGILEQGRFEREKLLNIQQQLTCSLRK--VEEENQGALEMIKRLKEENEKLN----EF 441
+ LEQ ER + + Q+ L S R + +N + K+L+ + +L E
Sbjct: 1690 ELWATLEQT--ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEV 1747
Query: 442 LELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQE 501
++ R+ K + + + E LK E + +HL E+ K V+ + E
Sbjct: 1748 IQESRNAEEKAKKAITDAAMMAEELKKEQDT-SAHL--ERMKKNLEQTVKDLQHRLDEAE 1804
Query: 502 MLKVARAEKDLLELSC----------NELRQELLKANGEIKH---VSSLLAKVEKDYSY- 547
L + +K + +L NE ++ G KH V L + E+D
Sbjct: 1805 QLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNV 1864
Query: 548 --LKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQL 604
L+++ D ++ + +E +S+A + ++ ELE+ E+ + N+L
Sbjct: 1865 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKL 1923
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 95.9 bits (237), Expect = 1e-19
Identities = 142/598 (23%), Positives = 246/598 (41%), Gaps = 65/598 (10%)
Query: 140 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN-------SEGAASHTGDS 192
+TE + ++E+ + ++EL+ E + + L+EK++ L N +E A +
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEE 907
Query: 193 SC----PTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 248
C T I E+ T + + D +E NA T+ + + L D
Sbjct: 908 RCDQLIKTKIQLEAKIKEVT--ERAEDEEEI------NAELTAKKRKLEDECSELKKDID 959
Query: 249 DFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAE 308
D E A+ + K +T N E +A L E I K+ + + E
Sbjct: 960 DLELTLAKV------------EKEKHATENKVKNLTEE--MAGLDETIAKLTKEKKALQE 1005
Query: 309 ELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL---MNL 365
Q TL +L ++ V LT KL + LE S Q ++ L + KL + L
Sbjct: 1006 AHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKL 1065
Query: 366 LQERVKNEEPTTQE--GKIIELEQKCTGILEQGRFEREKLLNIQ-----QQLTCSLRKVE 418
QE + E Q+ K+ + E + + + QG+ E E+ L IQ ++L + ++E
Sbjct: 1066 AQESTMDTENDKQQLNEKLKKKEFEMSNL--QGKIEDEQALAIQLQKKIKELQARIEELE 1123
Query: 419 EENQGALEMIKRLKEENEKLNEFLELERHNNNM-------MAKTLEECRVTLEGLKMENG 471
EE + E R K E ++ + ELE + + A+ + E KM
Sbjct: 1124 EEIEA--ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRD 1181
Query: 472 SLKSHLQGEKQKATEASAVEQTAES-CEVQEMLKVARAEKDLLELSCNELRQELLKANGE 530
+S LQ E AT A+ ++ A+S E+ E + + K LE +EL+ E+
Sbjct: 1182 LEESTLQHE---ATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASN 1238
Query: 531 IKHVSSLLAKVEKDYSYLKEICDH---QAEQLSRTSLKLQEKASESDAEIKDMKETIFEL 587
++ VS A EK L++ + E+ R +L + + E + + E
Sbjct: 1239 METVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEK 1298
Query: 588 EDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ---MKEETEEWRRFQ 644
+ V Q K Q I EL+ + + + KS L L++ ++E+ EE + +
Sbjct: 1299 DAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAK 1358
Query: 645 ADLQTAVVVANDIKCEAQQELRTVKRKLLEE-EEKNARLQKELGDVQGHGRVVTSRAA 701
A+LQ + AN + + + T + EE EE +L + L D + H V S+ A
Sbjct: 1359 AELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCA 1416
Score = 78.2 bits (191), Expect = 2e-14
Identities = 95/405 (23%), Positives = 177/405 (43%), Gaps = 58/405 (14%)
Query: 295 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 354
K + E+ + EE + T +EL+ + +EL + L+ EK L+ Q + A+
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL---QVQAEADA 901
Query: 355 LSQENEKLMNLLQERVKNE----EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQL 410
L+ E+ L++ +++ E E T + E+ + T + E +L L
Sbjct: 902 LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 961
Query: 411 TCSLRKVEEENQGALEMIKRLKEENEKLNEFL-ELERHNNNMMAKTLEEC-RVTLEGLKM 468
+L KVE+E +K L EE L+E + +L + K L+E + TL+ L+M
Sbjct: 962 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK-----KALQEAHQQTLDDLQM 1016
Query: 469 ENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKAN 528
E + + + + + + +E + E EK L C +L + K
Sbjct: 1017 EEDKVNTLTKAKTKLEQQVDDLEGSLEQ------------EKKL----CMDLERAKRKLE 1060
Query: 529 GEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEK---ASESDAEIKDMKETIF 585
G++K E D L E + ++S K++++ A + +IK+++ I
Sbjct: 1061 GDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIE 1120
Query: 586 ELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQA 645
ELE+++E RA S K E+Q+SDL R+L+ ++++++E A
Sbjct: 1121 ELEEEIEAERA--------------SRAKAEKQRSDLSRELEEISERLEE---------A 1157
Query: 646 DLQTAVVVANDIKCEA--QQELRTVKRKLLEEEEKNARLQKELGD 688
T+ + + K EA Q+ R ++ L+ E A L+K+ D
Sbjct: 1158 GGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHAD 1202
Score = 71.2 bits (173), Expect = 3e-12
Identities = 128/661 (19%), Positives = 252/661 (38%), Gaps = 74/661 (11%)
Query: 81 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 140
EK A E++V+ L E D I +L E K +E + V+ + +
Sbjct: 971 EKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTK 1030
Query: 141 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKL-IYLEHSPNSEGAASHTGDSSCPTSIT 199
E + LE + +K DLE R L+ L + E + ++E +
Sbjct: 1031 LEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFE 1090
Query: 200 QESSFGSPTGNQ-MSSDIDEYKKNIHGNALRTSGSSSSD-VTKASLSPDASDFEHITAET 257
+ G Q ++ + + K + ++ ++A SD
Sbjct: 1091 MSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDL------- 1143
Query: 258 PSRPLSSTSNPFKSSKCSTAGS-SPNSVSELSLASLTEKIQKMEENHHSTAEELQAT-LQ 315
SR L S + + +T+ N E + +++ H +TA L+
Sbjct: 1144 -SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHAD 1202
Query: 316 ELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQEN---EKLMNLLQERVKN 372
+++ + + L +KL EK+ L+ + E +S+ EK+ L++++
Sbjct: 1203 SVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSE 1262
Query: 373 EEPTTQEGK--IIELE-QKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIK 429
+ +E + I EL QK E G F R+ L+ + + L + ++ +E +K
Sbjct: 1263 IKTKEEEQQRLINELSAQKARLHTESGEFSRQ--LDEKDAMVSQLSRGKQAFTQQIEELK 1320
Query: 430 RLKEENEK----LNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKAT 485
R EE K L L+ RH+ +++ + EE + L+ S + + K
Sbjct: 1321 RQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKY- 1379
Query: 486 EASAVEQTAESCEVQ----EMLKVARAEKDLLELSCNELRQELLKANGEI---------- 531
E A+++T E E + + L+ A + + C L + + E+
Sbjct: 1380 ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERS 1439
Query: 532 -----------KHVSSLLAKVEKDYSYLK---EICDHQAEQLSRTSLKLQEKASESDAEI 577
++ +LA+ ++ Y + E ++ LS K++ ES +
Sbjct: 1440 NAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHL 1499
Query: 578 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 637
+ +K L+ ++ + I ELE +L+ +KS+L+ L+ ++ E
Sbjct: 1500 ETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEE 1559
Query: 638 EEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVT 697
+ R Q +L N +K E + RK+ E++E+ +L++ H RVV
Sbjct: 1560 GKILRIQLEL-------NQVKSE-------IDRKIAEKDEELDQLKR------NHLRVVE 1599
Query: 698 S 698
S
Sbjct: 1600 S 1600
Score = 68.6 bits (166), Expect = 2e-11
Identities = 128/666 (19%), Positives = 253/666 (37%), Gaps = 87/666 (13%)
Query: 58 NTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKR 117
N K + + K E+E L+ +++EL A + + EI R+ K +++R
Sbjct: 1081 NEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1140
Query: 118 TLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLE 177
+ + + + ++ G T I +++ FQK DLEE L+
Sbjct: 1141 SDLSRELEEISERLEEAG---GATSAQIEMNKKREAEFQKMRRDLEEST---------LQ 1188
Query: 178 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNA--LRTSGSSS 235
H + DS + ++ ++ + E K I+ A + T +
Sbjct: 1189 HEATAAALRKKHADS--VAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAK 1246
Query: 236 SDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEK 295
++ K + + E T E + L + + K+ + +G + E ++ +
Sbjct: 1247 ANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKD--AMVSQ 1304
Query: 296 IQKMEENHHSTAEELQATLQE---------------------LSDQQQMVQELTAE---- 330
+ + ++ EEL+ L+E L +Q + QE AE
Sbjct: 1305 LSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRG 1364
Query: 331 ----NEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELE 386
N ++ +T ET Q R E+L + +KL LQ+ ++ E + +E
Sbjct: 1365 MSKANSEVAQWRTKYETDAIQ---RTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKT 1421
Query: 387 QKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELER 446
+ ++ + E E L+ ++ + ++++ + +++ K++ E+ LE +
Sbjct: 1422 K------QRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQ 1475
Query: 447 HNNNMMAKTL-------EECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEV 499
+ ++ L EE LE LK EN +LQ E TE A E E+
Sbjct: 1476 KESRSLSTELFKVKNAYEESLDHLETLKREN----KNLQQEISDLTEQIA-EGGKHIHEL 1530
Query: 500 QEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQL 559
+++ K EK L+ S E L G+I + L +V+ + D + +QL
Sbjct: 1531 EKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQL 1590
Query: 560 SRTSLKLQEK-ASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQ 618
R L++ E S DAEI+ + + ++ ++E + ++E Q
Sbjct: 1591 KRNHLRVVESMQSTLDAEIRSRNDAL------------------RIKKKMEGDLNEMEIQ 1632
Query: 619 KSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEK 678
+ RQ + ++ + Q L A+ +D+K + R E EE
Sbjct: 1633 LNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEEL 1692
Query: 679 NARLQK 684
A L++
Sbjct: 1693 RASLER 1698
Score = 64.3 bits (155), Expect = 4e-10
Identities = 141/702 (20%), Positives = 265/702 (37%), Gaps = 115/702 (16%)
Query: 82 KAALESQVREL---LAEAKAKDSEINRLRSELKKYKEKRTLNA-------EGTDALGPNV 131
KA E R L L+E K K+ E RL +EL K + + + DA+ +
Sbjct: 1246 KANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQL 1305
Query: 132 D-GTSVSPGDTEPMIRALEEKNKN-------FQKELSDLE------EENRVLKEKLIYLE 177
G E + R LEE+ K Q D + EE + K +L
Sbjct: 1306 SRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGM 1365
Query: 178 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNAL---RTSGSS 234
NSE A T + T+E Q D +E+ + ++ +T
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRL 1425
Query: 235 SSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTE 294
++V + + S+ I + R +K T S E SL+
Sbjct: 1426 QNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESR--SLST 1483
Query: 295 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAE--------------NEKLVDEKTI 340
++ K++ + + + L+ +E + QQ + +LT + ++L EK+
Sbjct: 1484 ELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSE 1543
Query: 341 LETSFHQHRERAEQLSQENEKLMNLLQE--RVKNEEPTTQEGKIIELEQ----------K 388
L+TS E L E K++ + E +VK+E K EL+Q
Sbjct: 1544 LQTSLE---EAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVES 1600
Query: 389 CTGILEQGRFEREKLLNIQQQLTCSLRKVEEE----NQGALEMIKRLKEEN--------- 435
L+ R L I++++ L ++E + N+ A E ++ L+
Sbjct: 1601 MQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLH 1660
Query: 436 --------EKLNEFLELERHNNNMMAKTLEECRVTLE----GLKMENGSL---------- 473
+ L E L + N+M +EE R +LE G KM L
Sbjct: 1661 LDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLL 1720
Query: 474 ----KSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANG 529
S + +K+ T+ S ++ E + +A+K + + + + +EL K
Sbjct: 1721 HTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAM--MAEELKKEQD 1778
Query: 530 EIKHVSSLLAKVEKDYSYLKEICDHQAEQLS-----RTSLKLQEKASESDAEIKDMKETI 584
H+ + +E+ L+ D +AEQL+ + KL+ + E ++E++ ++
Sbjct: 1779 TSAHLERMKKNMEQTVKDLQLRLD-EAEQLALKGGKKQIQKLEARVRELESEVESEQKHN 1837
Query: 585 FELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEE----- 639
E + +H E ++++L++ L+ ++K +Q +E E+
Sbjct: 1838 VEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNL 1897
Query: 640 --WRRFQADLQTAVVVANDIKCEAQQ---ELRTVKRKLLEEE 676
+R+ Q +L+ A A+ + + + + R V K++ EE
Sbjct: 1898 AKFRKLQHELEEAKERADIAESQVNKLRVKSREVHTKVISEE 1939
Score = 50.8 bits (120), Expect = 4e-06
Identities = 114/615 (18%), Positives = 243/615 (39%), Gaps = 73/615 (11%)
Query: 48 RKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEA-KAKDSEINRL 106
++ +S S TK+ + ++ E +K A Q E EA +K + + +
Sbjct: 1362 QRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKT 1421
Query: 107 RSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEEN 166
+ L+ E ++ E ++A +D + + ++ ++K + Q EL ++E+
Sbjct: 1422 KQRLQNEVEDLMIDVERSNAACIALDKKQ---RNFDKVLAEWKQKYEETQAELEASQKES 1478
Query: 167 RVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGN 226
R L +L ++++ E + H ++ +E+ + ++ I E K+IH
Sbjct: 1479 RSLSTELFKVKNA--YEESLDHL------ETLKRENKNLQQEISDLTEQIAEGGKHIH-- 1528
Query: 227 ALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSE 286
+ K L + S+ + E + S K + + S +
Sbjct: 1529 --------ELEKVKKQLDHEKSELQTSLEEAEA---SLEHEEGKILRIQLELNQVKSEID 1577
Query: 287 LSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFH 346
+A E++ +++ NH E +Q+TL + + + E ++E I H
Sbjct: 1578 RKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLN--H 1635
Query: 347 QHRERAEQLSQENEKLMNL------LQERVKNEEPTTQEGKIIELE--------QKCTGI 392
+R+ AE L L L + ++ ++ ++ ++E ++
Sbjct: 1636 ANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRAS 1695
Query: 393 LEQGRFEREKLLNIQQQLTCSLRK--VEEENQGALEMIKRLKEE----NEKLNEFLELER 446
LE R ER + + Q+ L S R + +N + K+L+ + ++ + ++ R
Sbjct: 1696 LE--RTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEAR 1753
Query: 447 HNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEV------Q 500
+ K + + + E LK E + +HL+ K+ +EQT + ++ Q
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDT-SAHLERMKKN------MEQTVKDLQLRLDEAEQ 1806
Query: 501 EMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLS 560
LK + + LE EL E+ E KH + + K +KE+ +Q E+
Sbjct: 1807 LALKGGKKQIQKLEARVRELESEV---ESEQKHNVEAVKGLRKHERRVKELT-YQTEEDR 1862
Query: 561 RTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKS 620
+ L+LQ+ + ++K K E E+Q + A +L+ + + +E+
Sbjct: 1863 KNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLA-------KFRKLQHELEEAKERAD 1915
Query: 621 DLERQLKTLTKQMKE 635
E Q+ L + +E
Sbjct: 1916 IAESQVNKLRVKSRE 1930
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 95.5 bits (236), Expect = 1e-19
Identities = 137/616 (22%), Positives = 249/616 (40%), Gaps = 101/616 (16%)
Query: 140 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN-----------SEGAASH 188
+TE + ++E+ + ++EL+ E + + L+EK++ L N S A
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEE 907
Query: 189 TGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 248
D T I E+ T + + D +E NA T+ + + L D
Sbjct: 908 RCDQLIKTKIQLEAKIKEVT--ERAEDEEEI------NAELTAKKRKLEDECSELKKDID 959
Query: 249 DFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAE 308
D E +T + +T N K+ AG + ++A LT++ + ++E H T +
Sbjct: 960 DLE-LTLAKVEKEKHATENKVKNLTEEMAG------LDETIAKLTKEKKALQEAHQQTLD 1012
Query: 309 ELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL---MNL 365
+LQA ++ V LT KL + LE S Q ++ L + KL + L
Sbjct: 1013 DLQA-------EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKL 1065
Query: 366 LQERVKNEEPTTQ--EGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQG 423
QE + E Q + K+ + E + +G+ Q + E E+ L +Q Q
Sbjct: 1066 AQESTMDIENDKQQLDEKLKKKEFEMSGL--QSKIEDEQALGMQLQ-------------- 1109
Query: 424 ALEMIKRLKEENEKLNEFLELER-------HNNNMMAKTLEECRVTLEGLKMENGSLKSH 476
+ IK L+ E+L E +E ER + +++ LEE E L+ G+ +
Sbjct: 1110 --KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS---ERLEEAGGATSAQ 1164
Query: 477 LQGEKQKATEASAVEQTAESCEVQEMLKVARAEK-------------DLLELSCNELRQE 523
++ K++ E + + E +Q A K D L+ +L +E
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKE 1224
Query: 524 LLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKET 583
+ EI ++S + V K L+++C +QLS +++ K E I D+
Sbjct: 1225 KSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLS----EIKTKEEEQQRLINDLTAQ 1280
Query: 584 IFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ----------- 632
L+ + ++ + L+S+L +Q +L+RQL+ K
Sbjct: 1281 RARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSS 1340
Query: 633 ------MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEE-EEKNARLQKE 685
++E+ EE + +A+LQ A+ AN + + + T + EE EE +L +
Sbjct: 1341 RHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1400
Query: 686 LGDVQGHGRVVTSRAA 701
L D + H V ++ A
Sbjct: 1401 LQDAEEHVEAVNAKCA 1416
Score = 78.6 bits (192), Expect = 2e-14
Identities = 153/704 (21%), Positives = 288/704 (40%), Gaps = 115/704 (16%)
Query: 82 KAALESQVREL---LAEAKAKDSEINRLRSELKKYKEK-RTLNAEGTDALGPNVDGTSVS 137
K LE R L L+E K K+ E RL ++L + + +T + E + L S
Sbjct: 1246 KGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQL 1305
Query: 138 PGDTEPMIRALEEKNKNFQKE--------------------LSDLEEENRVLKEKLIYLE 177
+ + +EE + ++E L + EE + K +L
Sbjct: 1306 SRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAM 1365
Query: 178 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNAL---RTSGSS 234
NSE A T + T+E Q D +E+ + ++ +T
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRL 1425
Query: 235 SSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTE 294
++V + + ++ + R +K KC + + S+ SL+
Sbjct: 1426 QNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQ-KCEETHAELEA-SQKESRSLST 1483
Query: 295 KIQKMEENHHSTAEELQATLQELSDQQQMVQELT---AENEKLVDEKTILETSFHQHRER 351
++ K++ + + ++L+ +E + QQ + +LT AE K + H+ +
Sbjct: 1484 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRI----------HELEKI 1533
Query: 352 AEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGIL-EQGRFEREKLLNIQQQL 410
+Q+ QE +L L+E + E +EGKI+ ++ + + E R EK I Q
Sbjct: 1534 KKQVEQEKSELQAALEEAEASLEH--EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMK 1591
Query: 411 TCSLRKVEE-------ENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTL 463
+R VE E + + I+ K+ LNE H N M A+ L R T
Sbjct: 1592 RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQ 1651
Query: 464 EGLKMENGSLKSHLQGEKQKATEASAVEQTAE--SCEVQEMLKVARAEKDLLELSCNELR 521
LK L L+ ++ + + VE+ A E++E+ RA + E S
Sbjct: 1652 AILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEEL----RATLEQTERSRKIAE 1707
Query: 522 QELLKANGEIKHV----SSLL---AKVEKDYSYLK-EICD-----HQAEQLSRTSL---- 564
QELL A+ ++ + +SL+ K+E D S ++ E+ D AE+ ++ ++
Sbjct: 1708 QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAA 1767
Query: 565 -------KLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLH-NNQLISELESSVIKLE 616
K Q+ ++ + K++++T+ +L+ ++++ + L + I +LE+ V +LE
Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELE 1827
Query: 617 -----EQKSDL---------ERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQ 662
EQK ++ ER++K LT Q +E+ + R Q D+ + Q
Sbjct: 1828 GEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQ-----------DLVDKLQ 1876
Query: 663 QELRTVKRKLLEEEE-------KNARLQKELGDVQGHGRVVTSR 699
++++ KR+ E EE K R+Q EL + + + S+
Sbjct: 1877 AKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQ 1920
Score = 74.3 bits (181), Expect = 4e-13
Identities = 94/406 (23%), Positives = 176/406 (43%), Gaps = 60/406 (14%)
Query: 295 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 354
K + E+ + EE + T +EL+ + +EL + L+ EK L+ Q + A+
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL---QVQAEADS 901
Query: 355 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 414
L+ E+ L++ + I+LE K + E+ E E I +LT
Sbjct: 902 LADAEERCDQLIKTK-------------IQLEAKIKEVTERAEDEEE----INAELTAKK 944
Query: 415 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 474
RK+E+E +K+ ++ E +E E+H K L E L+ + K
Sbjct: 945 RKLEDE----CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK 1000
Query: 475 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDL---LELSCNELRQELLKAN--- 528
LQ Q+ + E+ + + +K+ + DL LE ++R +L +A
Sbjct: 1001 KALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE-KKIRMDLERAKRKL 1059
Query: 529 -GEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKAS---ESDAEIKDMKETI 584
G++K +E D L E + ++S K++++ + + +IK+++ I
Sbjct: 1060 EGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARI 1119
Query: 585 FELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQ 644
ELE+++E RA S K E+Q+SDL R+L+ ++++++E
Sbjct: 1120 EELEEEIEAERA--------------SRAKAEKQRSDLSRELEEISERLEE--------- 1156
Query: 645 ADLQTAVVVANDIKCEA--QQELRTVKRKLLEEEEKNARLQKELGD 688
A T+ + + K EA Q+ R ++ L+ E A L+K+ D
Sbjct: 1157 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1202
Score = 74.3 bits (181), Expect = 4e-13
Identities = 138/646 (21%), Positives = 261/646 (40%), Gaps = 102/646 (15%)
Query: 64 KHLRTPSTKPKQENEGGEKAALESQV------RELLAEAKAKDSEINRLRSELKKYKEKR 117
K +R + K++ EG K A ES + ++L + K K+ E++ L+S K ++++
Sbjct: 1046 KKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQS---KIEDEQ 1102
Query: 118 TLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLE 177
L + L + + E I A +K+ SDL E + E+L
Sbjct: 1103 ALGMQ----LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL---- 1154
Query: 178 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSD 237
+ GA S + + +E+ F +M D++E A +
Sbjct: 1155 --EEAGGATS----AQIEMNKKREAEF-----QKMRRDLEEATLQHEATAATLRKKHADS 1203
Query: 238 VTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSEL--SLASLTEK 295
V A L + + + + L + K + S+ +VS+ +L +
Sbjct: 1204 V--AELGEQIDNLQRV-----KQKLEKEKSEMKM-EIDDLASNMETVSKAKGNLEKMCRA 1255
Query: 296 IQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQL 355
++ + EE Q + +L+ Q+ +Q + E + +DEK L + + ++
Sbjct: 1256 LEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQA---F 1312
Query: 356 SQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLR 415
+Q+ E+L L+E +K + + C + EQ E+E +Q+ ++ +
Sbjct: 1313 TQQIEELKRQLEEEIKAKSALAHA--LQSSRHDCDLLREQYEEEQEAKAELQRAMSKANS 1370
Query: 416 KVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKS 475
+V + R K E + + ELE + A+ L++ +E + + SL+
Sbjct: 1371 EVAQW---------RTKYETDAIQRTEELEEAKKKL-AQRLQDAEEHVEAVNAKCASLEK 1420
Query: 476 HLQGEKQKATEASA-VEQTAESCEVQEMLKVARAEKDLLELS--CNELRQELLKANGEIK 532
Q + + + VE+T +C + K +K L E C E EL + E +
Sbjct: 1421 TKQRLQNEVEDLMIDVERTNAACAALDK-KQRNFDKILAEWKQKCEETHAELEASQKESR 1479
Query: 533 HVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVE 592
+S+ L K++ Y +E D Q E L R + LQ+ EI D+ E I E
Sbjct: 1480 SLSTELFKIKNAY---EESLD-QLETLKRENKNLQQ-------EISDLTEQIAE------ 1522
Query: 593 QHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVV 652
+ I ELE ++E++KS+L+ L+ ++ E + R Q +L
Sbjct: 1523 --------GGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLEL----- 1569
Query: 653 VANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTS 698
N +K E V RK+ E++E+ ++++ H R+V S
Sbjct: 1570 --NQVKSE-------VDRKIAEKDEEIDQMKR------NHIRIVES 1600
Score = 70.1 bits (170), Expect = 7e-12
Identities = 119/649 (18%), Positives = 259/649 (39%), Gaps = 64/649 (9%)
Query: 64 KHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEG 123
K + K E+E L+ +++EL A + + EI R+ K +++R+ +
Sbjct: 1087 KEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE 1146
Query: 124 TDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSE 183
+ + ++ G T I +++ FQK DLEE L+H +
Sbjct: 1147 LEEISERLEEAG---GATSAQIEMNKKREAEFQKMRRDLEEAT---------LQHEATAA 1194
Query: 184 GAASHTGDSSCP-----TSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDV 238
DS ++ + ++M +ID+ N + T + ++
Sbjct: 1195 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN-----METVSKAKGNL 1249
Query: 239 TKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQK 298
K + + E T E + L + ++ + +G + E +L ++ +
Sbjct: 1250 EKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKD--TLVSQLSR 1307
Query: 299 MEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQE 358
++ EEL+ L+E + + + D +L + + +E +L +
Sbjct: 1308 GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCD---LLREQYEEEQEAKAELQRA 1364
Query: 359 NEKL-MNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKV 417
K + Q R K E Q + +E +K Q E + +N + SL K
Sbjct: 1365 MSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAK---CASLEKT 1421
Query: 418 EEENQGALE-MIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSH 476
++ Q +E ++ ++ N + +R+ + ++A+ ++C T + L++
Sbjct: 1422 KQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEET-------HAELEAS 1474
Query: 477 LQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSS 536
+ + +TE ++ E E + L+ + E L+ ++L +++ + I +
Sbjct: 1475 QKESRSLSTELFKIKNAYE--ESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK 1532
Query: 537 LLAKVEKDYSYLKEI-------CDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELED 589
+ +VE++ S L+ +H+ ++ R L+L + SE D +I + E I D
Sbjct: 1533 IKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI----D 1588
Query: 590 QVEQH--RAVKLHNNQLISELESS------VIKLEEQKSDLERQLKTLTKQMKEETEEWR 641
Q++++ R V+ + L +E+ S K+E +++E QL + E +R
Sbjct: 1589 QMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYR 1648
Query: 642 RFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 690
QA L+ + +D A + +K +L E + LQ E+ +++
Sbjct: 1649 NTQAILKDTQLHLDD----ALRSQEDLKEQLAMVERRANLLQAEIEELR 1693
Score = 64.3 bits (155), Expect = 4e-10
Identities = 150/691 (21%), Positives = 271/691 (39%), Gaps = 115/691 (16%)
Query: 82 KAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDT 141
K LE++++E+ A+ ++ EIN +EL +KR L E ++ L ++D ++
Sbjct: 916 KIQLEAKIKEVTERAEDEE-EIN---AELTA--KKRKLEDECSE-LKKDIDDLELTLAKV 968
Query: 142 EPMIRALEEKNKNFQKELSDLEEE-NRVLKEKLIYLE-HSPNSEG--AASHTGDSSCPTS 197
E A E K KN +E++ L+E ++ KEK E H + A ++
Sbjct: 969 EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK 1028
Query: 198 ITQESSFGSPTGN-----QMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPD----AS 248
I E G+ ++ D++ K+ + G+ L+ + S+ D+ D
Sbjct: 1029 IKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGD-LKLAQESTMDIENDKQQLDEKLKKK 1087
Query: 249 DF----------------------------------EHITAETPSR-----PLSSTSNPF 269
+F E I AE SR S S
Sbjct: 1088 EFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1147
Query: 270 K--SSKCSTAGSSPNSVSELSLASLTEKIQKMEEN-------HHSTAEELQA----TLQE 316
+ S + AG + ++ E++ E QKM + H +TA L+ ++ E
Sbjct: 1148 EEISERLEEAGGATSAQIEMNKKREAE-FQKMRRDLEEATLQHEATAATLRKKHADSVAE 1206
Query: 317 LSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQER---VKNE 373
L +Q +Q + + EK E + + E + EK+ L+++ +K +
Sbjct: 1207 LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTK 1266
Query: 374 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 433
E Q Q+ E G + R+ L+ + L L + ++ +E +KR E
Sbjct: 1267 EEEQQRLINDLTAQRARLQTESGEYSRQ--LDEKDTLVSQLSRGKQAFTQQIEELKRQLE 1324
Query: 434 ENEK----LNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASA 489
E K L L+ RH+ +++ + E E K+ LQ KA A
Sbjct: 1325 EEIKAKSALAHALQSSRHDCDLLREQYE-----------EEQEAKAELQRAMSKANSEVA 1373
Query: 490 VEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLK 549
+T + + R E+ LE + +L Q L A ++ V++ A +EK L+
Sbjct: 1374 QWRTKYETDA-----IQRTEE--LEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQ 1426
Query: 550 EICDHQAEQLSRTS---LKLQEKASESDAEIKDMK----ETIFELEDQVEQHRAVKLHNN 602
+ + RT+ L +K D + + K ET ELE ++ R++
Sbjct: 1427 NEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELF 1486
Query: 603 QLISELESSVIKLE---EQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKC 659
++ + E S+ +LE + +L++++ LT+Q+ E + +L+ K
Sbjct: 1487 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH----ELEKIKKQVEQEKS 1542
Query: 660 EAQQELRTVKRKLLEEEEKNARLQKELGDVQ 690
E Q L + L EE K R+Q EL V+
Sbjct: 1543 ELQAALEEAEASLEHEEGKILRIQLELNQVK 1573
Score = 62.4 bits (150), Expect = 1e-09
Identities = 74/303 (24%), Positives = 127/303 (41%), Gaps = 56/303 (18%)
Query: 414 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 473
L+ E E + A +KEE EK E E K LEE VTL E L
Sbjct: 844 LKSAETEKEMA-----NMKEEFEKTKE----ELAKTEAKRKELEEKMVTL---MQEKNDL 891
Query: 474 KSHLQGEKQKATEA---------------SAVEQTAESCEVQEMLKVA-RAEKDLLELSC 517
+ +Q E +A + +++ E E +E + A+K LE C
Sbjct: 892 QLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 951
Query: 518 NELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEI 577
+EL+++ I + LAKVEK+ K +++ + L+ L E ++ E
Sbjct: 952 SELKKD-------IDDLELTLAKVEKE----KHATENKVKNLTEEMAGLDETIAKLTKEK 1000
Query: 578 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 637
K ++E + D ++ ++ L + IKLE+Q DLE L+ K +
Sbjct: 1001 KALQEAHQQTLDDLQAEE-------DKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLE 1053
Query: 638 EEWRRFQADLQTAVVVANDIKCEAQQ----------ELRTVKRKLLEEEEKNARLQKELG 687
R+ + DL+ A DI+ + QQ E+ ++ K+ +E+ +LQK++
Sbjct: 1054 RAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIK 1113
Query: 688 DVQ 690
++Q
Sbjct: 1114 ELQ 1116
Score = 54.7 bits (130), Expect = 3e-07
Identities = 112/511 (21%), Positives = 198/511 (38%), Gaps = 97/511 (18%)
Query: 74 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 133
KQ N A + + E AE +A E L +EL K K +A ++D
Sbjct: 1449 KQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIK----------NAYEESLD- 1497
Query: 134 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEE---------------NRVLKEKLIYLEH 178
+ L+ +NKN Q+E+SDL E+ +V +EK
Sbjct: 1498 ----------QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAA 1547
Query: 179 SPNSEGAASHTGDS--SCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGS--- 233
+E + H + Q S + +ID+ K+N H + + S
Sbjct: 1548 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRN-HIRIVESMQSTLD 1606
Query: 234 ----SSSDVT--KASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSEL 287
S +D K + D ++ E I +R + +++++ + + L
Sbjct: 1607 AEIRSRNDAIRLKKKMEGDLNEME-IQLNHANRMAAEALRNYRNTQAILKDTQLHLDDAL 1665
Query: 288 -SLASLTEKIQKMEENHH---STAEELQATL-----------QELSDQQQMVQELTAENE 332
S L E++ +E + + EEL+ATL QEL D + VQ L +N
Sbjct: 1666 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1725
Query: 333 KLVDEKTILETSFHQHRERAEQLSQE----NEKLMN------LLQERVKNEEPTTQEGKI 382
L++ K LET Q + E + QE EK ++ E +K E+ T+ +
Sbjct: 1726 SLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785
Query: 383 IELEQKCTGILEQGRFEREKLLNIQ------QQLTCSLR----KVEEENQGALEMIKRLK 432
++ + T Q R + + L ++ Q+L +R +VE E + +E +K L+
Sbjct: 1786 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLR 1845
Query: 433 EENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQ 492
+ K+ E + EE R + L+ L++ ++ K++A EA
Sbjct: 1846 KHERKVKE-----------LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSN 1894
Query: 493 T--AESCEVQEMLKVARAEKDLLELSCNELR 521
++ +Q L+ A D+ E N+LR
Sbjct: 1895 VNLSKFRRIQHELEEAEERADIAESQVNKLR 1925
Score = 47.8 bits (112), Expect = 4e-05
Identities = 114/607 (18%), Positives = 224/607 (36%), Gaps = 94/607 (15%)
Query: 48 RKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEA-KAKDSEINRL 106
++++S S TK+ + ++ E +K A Q E EA AK + + +
Sbjct: 1362 QRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKT 1421
Query: 107 RSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEEN 166
+ L+ E ++ E T+A +D + + ++ ++K + EL ++E+
Sbjct: 1422 KQRLQNEVEDLMIDVERTNAACAALDKKQ---RNFDKILAEWKQKCEETHAELEASQKES 1478
Query: 167 RVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHG- 225
R L +L ++++ T + +E+ + ++ I E K IH
Sbjct: 1479 RSLSTELFKIKNAYEESLDQLET--------LKRENKNLQQEISDLTEQIAEGGKRIHEL 1530
Query: 226 NALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVS 285
++ +A+L + EH E + N KS
Sbjct: 1531 EKIKKQVEQEKSELQAALEEAEASLEH--EEGKILRIQLELNQVKSEV------------ 1576
Query: 286 ELSLASLTEKIQKMEENHHSTAEELQATLQ---------------------ELSDQQQMV 324
+ +A E+I +M+ NH E +Q+TL E+ Q
Sbjct: 1577 DRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHA 1636
Query: 325 QELTAENEK--------LVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPT 376
+ AE + L D + L+ + + EQL+ E+ NLLQ ++ T
Sbjct: 1637 NRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMV-ERRANLLQAEIEELRAT 1695
Query: 377 TQEGKIIELEQKCTGILEQGRF---EREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 433
+E ++ I EQ ER +LL+ Q + +K E + I +++
Sbjct: 1696 ------LEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD------ISQIQG 1743
Query: 434 ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT 493
E E + ++ R+ K + + + E LK E + +HL E+ K V+
Sbjct: 1744 EME---DIIQEARNAEEKAKKAITDAAMMAEELKKEQDT-SAHL--ERMKKNLEQTVKDL 1797
Query: 494 AESCEVQEMLKVARAEKDL--LELSCNELRQE--------------LLKANGEIKHVSSL 537
+ E L + +K + LE EL E L K ++K ++
Sbjct: 1798 QHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQ 1857
Query: 538 LAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAV 597
+ K+ L+++ D ++ + +E +S+ + + ELE+ E+
Sbjct: 1858 TEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIA 1917
Query: 598 KLHNNQL 604
+ N+L
Sbjct: 1918 ESQVNKL 1924
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 94.0 bits (232), Expect = 4e-19
Identities = 125/575 (21%), Positives = 244/575 (42%), Gaps = 93/575 (16%)
Query: 151 KNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGN 210
K+ +KE++ ++E+ KE+L SE + S+ QE N
Sbjct: 845 KSAEAEKEMATMKEDFERTKEELA------RSEARRKELEEKM--VSLLQEK-------N 889
Query: 211 QMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFK 270
+ + +N+ R G S + + + ++ E S ++ N
Sbjct: 890 DLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRN--L 947
Query: 271 SSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAE 330
KCS S + +L L + K+E+ H+T +++ +E++ ++ + +LT E
Sbjct: 948 EDKCS---SLKRDIDDLELT-----LTKVEKEKHATENKVKNLSEEMTALEENISKLTKE 999
Query: 331 NEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCT 390
+ L + H++ + L E +K+ L++ K E+ T +E E+K
Sbjct: 1000 KKSLQEA----------HQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLR 1049
Query: 391 GILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNN 450
LE+ + + E L + Q+ S+ +E + Q E +K+ + E +L ++ E+ ++
Sbjct: 1050 ADLERAKRKLEGDLKMSQE---SIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSL 1106
Query: 451 MMAKTLEECRVTLEGLKME---NGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVAR 507
K ++E + +E L+ E +L++ + EKQ++ A +E+ +E E A+
Sbjct: 1107 QFQKKIKELQARIEELEEEIEAEHTLRAKI--EKQRSDLARELEEISERLEEASGATSAQ 1164
Query: 508 AEKDLL-ELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKL 566
E + E ++R++L +A + + ++ L K + D + E+ + Q + L R KL
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADS--VAELGE-QIDNLQRVKQKL 1221
Query: 567 QEKASESDAEIKDMKETIFEL--------------EDQVEQHRAVKLHNNQLISEL---- 608
+++ SE EI DM I L EDQ + +A QLI +L
Sbjct: 1222 EKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQK 1281
Query: 609 -----------------ESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAV 651
ES + +L + K L +QL+ L +QM+EET+ LQ+
Sbjct: 1282 ARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQS-- 1339
Query: 652 VVANDIKCEAQQELRTVKRKLLEEEEKNARLQKEL 686
++ + ++ + EE+E A LQ+ L
Sbjct: 1340 ---------SRHDCDLLREQYEEEQEAKAELQRAL 1365
Score = 82.8 bits (203), Expect = 1e-15
Identities = 141/698 (20%), Positives = 274/698 (39%), Gaps = 103/698 (14%)
Query: 81 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKE--KRTLN------------------ 120
EK A E++V+ L E A + I++L E K +E ++TL+
Sbjct: 971 EKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAK 1030
Query: 121 -AEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEK------- 172
+ TD L +++ D E R LE K Q+ + DLE + + ++EK
Sbjct: 1031 LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFE 1090
Query: 173 LIYLEHSPNSEGAAS----------HTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKN 222
L L+ + E S I E + + Q SD+ +
Sbjct: 1091 LSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQ-RSDLARELEE 1149
Query: 223 IHGNALRTSGSSSSDV-----TKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTA 277
I SG++S+ + +A D E T + ++T ++ +
Sbjct: 1150 ISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQ--HEATAATLRKKQADSVAEL 1207
Query: 278 GSSPNSV-----------SEL-----SLASLTEKIQKMEENHHSTAEELQATLQEL---- 317
G +++ SEL +AS E + K + N T ++ E+
Sbjct: 1208 GEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKD 1267
Query: 318 SDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQE-RVKNEEPT 376
Q Q++ +L + +L + L + QL++ + L L+E + + EE T
Sbjct: 1268 EQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEET 1327
Query: 377 TQEGKIIELEQK----CTGILEQGRFEREKLLNIQQQLTCSLRKVEE----ENQGALEMI 428
+ + Q C + EQ E+E +Q+ L+ + +V + A++
Sbjct: 1328 KAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRT 1387
Query: 429 KRLKEENEKLNEFLELERHNN---NMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKAT 485
+ L+E +KL + L+ N N +LE+ + L+ G ++ ++ ++ T
Sbjct: 1388 EELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQ------GEVEDLMRDLERSHT 1441
Query: 486 EASAVEQTAES-----CEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAK 540
+ +++ + E ++ L ++AE + + L EL K + V L
Sbjct: 1442 ACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLET 1501
Query: 541 VEKDYSYLKEICDHQAEQLSRTSLKLQEKASES---DAEIKDMKETIFELEDQVEQHRA- 596
+ ++ L+E EQ++ T LQE + E D++ + E+E +E +
Sbjct: 1502 LRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESK 1561
Query: 597 ---VKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVV 653
V+L +Q+ SEL+ VI+ +E+ L+R + + ++ + R + D
Sbjct: 1562 ILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRND------- 1614
Query: 654 ANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQG 691
A +K + + +L ++ +L + A QK L VQG
Sbjct: 1615 ALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQG 1652
Score = 70.5 bits (171), Expect = 5e-12
Identities = 147/676 (21%), Positives = 274/676 (40%), Gaps = 85/676 (12%)
Query: 82 KAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDT 141
K LE++V+EL E ++ E+N SEL +KR L + +L ++D ++
Sbjct: 916 KILLEAKVKEL-TERLEEEEEMN---SEL--VAKKRNLE-DKCSSLKRDIDDLELTLTKV 968
Query: 142 EPMIRALEEKNKNFQKELSDLEEE-NRVLKEKLIYLE-HSPNSEGAASHTGDSSCPTSI- 198
E A E K KN +E++ LEE +++ KEK E H + + I
Sbjct: 969 EKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKIN 1028
Query: 199 ------TQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDV------TKASLSPD 246
T + ++ +D++ K+ + G+ L+ S S D+ + L
Sbjct: 1029 AKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGD-LKMSQESIMDLENDKQQIEEKLKKK 1087
Query: 247 ASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHST 306
+ + A+ + S K + E +L KI+K +
Sbjct: 1088 EFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAE-HTLRAKIEKQRSDLARE 1146
Query: 307 AEELQATLQELSD----QQQMVQELTAENEKL---VDEKTILE--TSFHQHRERAEQLSQ 357
EE+ L+E S Q +M ++ AE +K+ ++E T+ T+ +++A+ +++
Sbjct: 1147 LEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAE 1206
Query: 358 ENEKLMNLLQERVKNEEPTTQEGKIIE---------------LEQKCTGILEQGRFEREK 402
E++ NL + + K E+ ++ I+ +E+ C + +Q F K
Sbjct: 1207 LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQ--FSEIK 1264
Query: 403 LLNIQQ-QLTCSL---------------RKVEEENQGALEMIK---RLKEENEKLNEFLE 443
+ QQ QL L +VEE+ ++ K L ++ E+L +E
Sbjct: 1265 AKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQME 1324
Query: 444 LERHNNNMMAKTLEECRVTLEGLK---MENGSLKSHLQGEKQKATEASAVEQTAESCEVQ 500
E N MA L+ R + L+ E K+ LQ KA A +T +
Sbjct: 1325 EETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDA- 1383
Query: 501 EMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLS 560
+ R E+ LE + +L Q L +A + +S A +EK L+ + L
Sbjct: 1384 ----IQRTEE--LEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLE 1437
Query: 561 RT---SLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEE 617
R+ L +K D + + K+ + E + ++E + + + ++ ++ ++ +
Sbjct: 1438 RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVD 1497
Query: 618 QKSDLERQLKTLTKQMKEETEEWRRFQADLQTA---VVVANDIKCEAQQELRTVKRKLLE 674
Q L R+ K L +++ + TE+ +LQ A + K + Q L V+ L
Sbjct: 1498 QLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEH 1557
Query: 675 EEEKNARLQKELGDVQ 690
EE K R+Q EL V+
Sbjct: 1558 EESKILRVQLELSQVK 1573
Score = 68.9 bits (167), Expect = 1e-11
Identities = 93/408 (22%), Positives = 165/408 (40%), Gaps = 83/408 (20%)
Query: 294 EKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 353
E++ + E E++ + LQE +D Q VQ +E E L+D + ER E
Sbjct: 865 EELARSEARRKELEEKMVSLLQEKNDLQLQVQ---SETENLMDAE-----------ERCE 910
Query: 354 QLSQEN---EKLMNLLQERVKNEEPTTQE--GKIIELEQKCTGILEQGRFEREKLLNIQQ 408
L + E + L ER++ EE E K LE KC+ +
Sbjct: 911 GLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRD-----------ID 959
Query: 409 QLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEEC-RVTLEGLK 467
L +L KVE+E +K L EE L E + K+L+E + TL+ L+
Sbjct: 960 DLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEK----KSLQEAHQQTLDDLQ 1015
Query: 468 ME----NGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQE 523
+E NG +K + + E+Q ++EQ K RA+ L +
Sbjct: 1016 VEEDKVNGLIKINAKLEQQTDDLEGSLEQE----------KKLRAD----------LERA 1055
Query: 524 LLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASES---DAEIKDM 580
K G++K + +E D ++E + +LS+ K+ ++ S +IK++
Sbjct: 1056 KRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKEL 1115
Query: 581 KETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEW 640
+ I ELE+++E ++ K+E+Q+S L ++++E +E
Sbjct: 1116 QARIEELEEEIEAEHTLRA--------------KIEKQRS-------DLARELEEISERL 1154
Query: 641 RRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGD 688
+ + + E Q+ R ++ L+ E A L+K+ D
Sbjct: 1155 EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQAD 1202
Score = 66.2 bits (160), Expect = 1e-10
Identities = 145/717 (20%), Positives = 274/717 (38%), Gaps = 141/717 (19%)
Query: 64 KHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEG 123
K + K ++E + +++EL A + + EI + K +++R+ A
Sbjct: 1087 KEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARE 1146
Query: 124 TDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSE 183
+ + ++ S G T I +++ FQK DLEE L+H +
Sbjct: 1147 LEEISERLEEAS---GATSAQIEMNKKREAEFQKMRRDLEEAT---------LQHEATAA 1194
Query: 184 GAASHTGDSSCPTS------------ITQESSFGSPTGNQMSSDIDEYKKNIHGNALRT- 230
DS + +E S + M+S+I+ K+ N RT
Sbjct: 1195 TLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKS-KSNIERTC 1253
Query: 231 -------SGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNS 283
S + D + L D + + +T + LS K S S S +
Sbjct: 1254 RTVEDQFSEIKAKDEQQTQLIHDLN-MQKARLQTQNGELSHRVEE-KESLISQLTKSKQA 1311
Query: 284 VSELSLASLTEKIQKMEENHHSTAEELQATLQE---LSDQQQMVQELTAE--------NE 332
+++ L L ++++ + ++ A LQ++ + L +Q + QE AE N
Sbjct: 1312 LTQ-QLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANS 1370
Query: 333 KLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGI 392
++ +T ET Q R E+L + +KL LQE +N E T K LE+ +
Sbjct: 1371 EVAQWRTKYETDAIQ---RTEELEEAKKKLAQRLQEAEENTE--TANSKCASLEKTKQRL 1425
Query: 393 LEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMM 452
QG E E L+ ++ + ++++ + +++ K++ ++ LE + + +
Sbjct: 1426 --QG--EVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSL 1481
Query: 453 AKTL-------EECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKV 505
+ L EE LE L+ EN +L+ + + T + E + L+
Sbjct: 1482 STELFKMRNAYEEVVDQLETLRRENKNLQEEIS------------DLTEQIAETGKNLQE 1529
Query: 506 ARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQA-------EQ 558
A K L+E ++L+ L + G ++H S + +V+ + S +K D + EQ
Sbjct: 1530 AEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQ 1589
Query: 559 LSRTSLKLQEKA-SESDAEIK--------------DMKETIFEL---------------- 587
L R S + E S DAEI+ D+ E +L
Sbjct: 1590 LKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRT 1649
Query: 588 -------------------EDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKT 628
ED EQ V+ N L+ ELE + LE+ ER +
Sbjct: 1650 VQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQ----TERTRRL 1705
Query: 629 LTKQMKEETEEWRRFQADLQTAV-----VVANDIKCEAQQELRTVKRKLLEEEEKNA 680
+++ + ++ + + + + + A+ +C+A+ E + + EE+ K A
Sbjct: 1706 SEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKA 1762
Score = 64.3 bits (155), Expect = 4e-10
Identities = 129/638 (20%), Positives = 249/638 (39%), Gaps = 76/638 (11%)
Query: 85 LESQVRELLAEAKAKDSEINRLRSEL-------KKYKEKRTLNAEGTDALGPNVDGTSV- 136
LE R++ E KAK++ + L+S ++Y+E++ AE AL +
Sbjct: 1316 LEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQW 1375
Query: 137 -SPGDTEPMIRA--LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNS----------E 183
+ +T+ + R LEE K + L + EE K LE + +
Sbjct: 1376 RTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRD 1435
Query: 184 GAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASL 243
SHT +C T ++ +F + +DE + + A + S S S+++ K
Sbjct: 1436 LERSHT---ACATLDKKQRNFDKVLA-EWKQKLDESQAELEA-AQKESRSLSTELFKMRN 1490
Query: 244 SPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENH 303
+ + + T ++ L + T L A T+K+ + E++
Sbjct: 1491 AYEEVVDQLETLRRENKNLQEEISDLTEQIAETG-------KNLQEAEKTKKLVEQEKSD 1543
Query: 304 HSTA-EELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL 362
A EE++ +L+ + VQ ++ + +D K I + E EQL + +++
Sbjct: 1544 LQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVI------EKDEEIEQLKRNSQRA 1597
Query: 363 MNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQ 422
LQ + E + + + L++K G L + + + LR V+ + +
Sbjct: 1598 AEALQSVLDAEIRSRNDA--LRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLK 1655
Query: 423 GALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQ 482
+ + NE L E L + N ++ + LEE +V LE + + L
Sbjct: 1656 DSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASD 1715
Query: 483 KA-----------TEASAVEQTAESC--EVQEMLKVARAEKDLLELSCNE---LRQELLK 526
+ +E C EV+ ++ +R ++ + + + + +EL K
Sbjct: 1716 RVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKK 1775
Query: 527 ANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLS---------RTSLKLQEKASESDAEI 577
H+ + +E+ L+ D +AEQL+ + +++E +E D E
Sbjct: 1776 EQDTSAHLERMKKNLEQTVKDLQHRLD-EAEQLALKGGKKQIQKLENRVRELENELDVEQ 1834
Query: 578 KDMKETI-----FELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ 632
K E + +E + + ++A + H N I L+ V KL+ + +RQ + +Q
Sbjct: 1835 KRGAEALKGAHKYERKVKEMTYQAEEDHKN--ILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1892
Query: 633 MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKR 670
+ RR Q +L+ A A DI +LR R
Sbjct: 1893 ANTQLSRCRRVQHELEEAAERA-DIAESQVNKLRAKSR 1929
Score = 53.1 bits (126), Expect = 9e-07
Identities = 109/573 (19%), Positives = 221/573 (38%), Gaps = 47/573 (8%)
Query: 95 EAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVS-PGDTEPMIRALE---- 149
+A + E+ + +L + ++ N E ++ +++ T G+ E ++R LE
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHT 1441
Query: 150 ------EKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESS 203
+K +NF K L++ +++ + +L + S ++ + Q +
Sbjct: 1442 ACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLET 1501
Query: 204 FGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLS 263
N + +I + + I A ++ TK + + SD + E S
Sbjct: 1502 LRRENKN-LQEEISDLTEQI---AETGKNLQEAEKTKKLVEQEKSDLQVALEEVEG---S 1554
Query: 264 STSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQM 323
K + S S + + E+I++++ N AE LQ+ L +
Sbjct: 1555 LEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRND 1614
Query: 324 VQELTAENEKLVDEKTILETSFHQHRERAE----------QLSQENEKLMNLLQERVKNE 373
L + E ++E I H +R+ AE QL L + L+ +
Sbjct: 1615 ALRLKKKMEGDLNEMEI--QLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLK 1672
Query: 374 EPTT----QEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCS--LRKVEEENQGALEM 427
E + G ++E ++ LEQ ER + L+ Q+ L S ++ + +N +
Sbjct: 1673 EQLAIVERRNGLLLEELEEMKVALEQT--ERTRRLSEQELLDASDRVQLLHSQNTSLINT 1730
Query: 428 IKRLKEE----NEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQK 483
K+L+ + ++ ++ R+ K + + + E LK E + +HL E+ K
Sbjct: 1731 KKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDT-SAHL--ERMK 1787
Query: 484 ATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEK 543
V+ + E L + +K + +L N +R+ + + E K + L K
Sbjct: 1788 KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE-NRVRELENELDVEQKRGAEALKGAHK 1846
Query: 544 DYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQ 603
+KE+ +QAE+ + L+LQ+ + A++K K E E+Q +
Sbjct: 1847 YERKVKEMT-YQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQH 1905
Query: 604 LISELESSVIKLEEQKSDLERQLKTLTKQMKEE 636
+ E E Q + L + + + Q EE
Sbjct: 1906 ELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 94.0 bits (232), Expect = 4e-19
Identities = 139/645 (21%), Positives = 271/645 (42%), Gaps = 68/645 (10%)
Query: 81 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRT-LNAEGTDALGPNVDGTSVSPG 139
E L+ +++EL K +++I +S+L+ K+ + L E A TS+ G
Sbjct: 647 ENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDG 706
Query: 140 DTEPMIRA---LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPT 196
+ LE K + QKEL+ EEN L+E++I L +
Sbjct: 707 KVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDK 766
Query: 197 SITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAE 256
S +E + +++ S++ + + G L G + D+ + ++D E +
Sbjct: 767 S--EELHIITSEKDKLFSEVVHKESRVQG-LLEEIGKTKDDLATTQSNYKSTDQEFQNFK 823
Query: 257 TPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQE 316
T N + +L+++ QK + + + EL QE
Sbjct: 824 TLHMDFEQKYKMVLEE---------NERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQE 874
Query: 317 LSDQQQMVQELTAENEKLVDE----KTILETSFHQHRERAEQLSQENEKLMNLLQERVKN 372
L ++ + VQE E E+L ++ + L+T + E+L Q E++ L QE K+
Sbjct: 875 LQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQE--KD 932
Query: 373 EEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLK 432
+ QE IE +Q + I + ++ Q+QL +L +++ E I LK
Sbjct: 933 DLKQLQESLQIERDQLKSDIHDTVNMN----IDTQEQLRNALESLKQHQ----ETINTLK 984
Query: 433 EENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQ 492
K++E + H +T +E + + G+ + + Q + +EQ
Sbjct: 985 ---SKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQ 1041
Query: 493 -------TAESCEVQEMLKVARAEKDLLELSCN-------ELRQELLKANGEIKHVSSLL 538
E E+Q+ML+ AEK+ L+ E ++EL E+K ++
Sbjct: 1042 QRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIV 1101
Query: 539 AKVEKDYSYLKE-----ICDHQA---EQLSRTSLKLQEKASE---SDAEIKDMKETIFEL 587
A+ EK+++ KE CD A E+L S +LQEK + E+ +M++ I E+
Sbjct: 1102 AQ-EKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI 1160
Query: 588 EDQVEQHRAVKLHNNQL-ISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQAD 646
E+ + L N +L + +E+ ++L ++ ++ ++K++TK+ K E + F+ +
Sbjct: 1161 ENLKNE-----LKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETE 1215
Query: 647 LQTAVVVANDIKC---EAQQELRTVKRKLLEEEEKNARLQKELGD 688
+I+ + ++EL+ L E +E L++ + +
Sbjct: 1216 RDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE 1260
Score = 80.1 bits (196), Expect = 7e-15
Identities = 89/413 (21%), Positives = 184/413 (44%), Gaps = 40/413 (9%)
Query: 294 EKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENE--KLVDEKTILETSFHQHRER 351
E +Q + +E+ A ++E +++ ++TA NE + + E L+ F +
Sbjct: 1600 EALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLN 1659
Query: 352 AEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLL-NIQQQL 410
E + EN +L +L E ++ T+E + E + ER++L N+++ +
Sbjct: 1660 LENIETENIRLTQILHENLEEMRSVTKE------RDDLRSVEETLKVERDQLKENLRETI 1713
Query: 411 TCSLRKVEE---------ENQGALEMIKRLKEE--NEKLNEFLELERHNNNMMAKTL--- 456
T L K EE E+Q ++ ++ + E NE N +LE N+ + A+ L
Sbjct: 1714 TRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ 1773
Query: 457 EECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELS 516
EE R+ LK + ++ +K + S +++ E+ A+ ++ + EL
Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSN-------AKLQEKIQELK 1826
Query: 517 CNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAE 576
NE + LK K V+ KV + K+I D Q+ LS+ ++ A +
Sbjct: 1827 ANEHQLITLK-----KDVNETQKKVSEMEQLKKQIKD-QSLTLSKLEIENLNLAQKLHEN 1880
Query: 577 IKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEE 636
+++MK + E ++ +KL +QL L+ + + + +++++LKT KE
Sbjct: 1881 LEEMKSVMKERDNLRRVEETLKLERDQLKESLQET----KARDLEIQQELKTARMLSKEH 1936
Query: 637 TEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDV 689
E + + + + +DI+ + + +++K+ E ++K +L + DV
Sbjct: 1937 KETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDV 1989
Score = 78.6 bits (192), Expect = 2e-14
Identities = 118/647 (18%), Positives = 264/647 (40%), Gaps = 48/647 (7%)
Query: 66 LRTPSTKPKQENEG--------GEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKR 117
L+ K +ENE E +L S+V L E + K E++ + SE K +
Sbjct: 725 LQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEV 784
Query: 118 TLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLE 177
L + T T+ ++ +++ +NF+ D E++ +++ E+ +
Sbjct: 785 VHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMN 844
Query: 178 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSD 237
+ + DSS ++ E S+ + + + ++ E + +
Sbjct: 845 QEIVNLSKEAQKFDSSL-GALKTELSYKTQELQEKTREVQERLNEM-------------E 890
Query: 238 VTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQ 297
K L S + + E + L + + T + + +L + E+ Q
Sbjct: 891 QLKEQLENRDSTLQTVERE---KTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQ 947
Query: 298 KMEENHHS------TAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRER 351
+ H + T E+L+ L+ L Q+ + L ++ + V +E + + ++
Sbjct: 948 LKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDE 1007
Query: 352 AEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNI---QQ 408
+Q +K +L + + ++ +IIE ++K ++++ ++ L ++ ++
Sbjct: 1008 FQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKE 1067
Query: 409 QLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHN----NNMMAKTLEECRVTLE 464
QL L++ E E ++ L +E +K E + E+++ +++T + E
Sbjct: 1068 QLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE 1127
Query: 465 GLKMENGSLKSHLQGEKQKATEASAVEQTAESCE-VQEMLKVARAEKDLLELSCNELRQE 523
LK ++ L+ Q E S +++ E ++ LK + +E EL Q+
Sbjct: 1128 KLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK 1187
Query: 524 LLKANGEIKHVS---SLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDM 580
L + E+K ++ +L +++K + ++ ++ T L+ +E+ + +K+
Sbjct: 1188 LNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEH 1247
Query: 581 KETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDL--ERQLKTLTKQMKEETE 638
+ETI EL V + + ++ N Q +LE S KL+E+ L E++L K++ E E
Sbjct: 1248 QETIDELRRSVSE-KTAQIINTQ---DLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQE 1303
Query: 639 EWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKE 685
+ + + + + E + K E +E+ L KE
Sbjct: 1304 TMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE 1350
Score = 76.3 bits (186), Expect = 9e-14
Identities = 92/428 (21%), Positives = 201/428 (46%), Gaps = 36/428 (8%)
Query: 289 LASLTEKIQKMEE-NHHSTAEE--LQATLQELSDQQQMVQELTAENEKLVDEKTILETSF 345
++ + EK+ ++++ H A++ LQ+ ++ + +QE E + ++ EK ++
Sbjct: 1540 ISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQ 1599
Query: 346 HQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILE-QGRFEREKLL 404
+ +QL + ++++ ++E + E + + E ++K I + +FE +K L
Sbjct: 1600 EALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQK-L 1658
Query: 405 NIQQQLTCSLR--KVEEENQGALEMIKRLKEENEKLNEFLELERHN-NNMMAKTLEECRV 461
N++ T ++R ++ EN + + + +++ + E L++ER + +T+
Sbjct: 1659 NLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLE 1718
Query: 462 TLEGLKMENGSLKSHLQ----------------GEKQKATEASAVEQTAESCEVQEMLKV 505
E LK+ + LK H + QK E S A+ ++QE L++
Sbjct: 1719 KQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRI 1778
Query: 506 ARAEKDLLELSCNELR----QELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSR 561
A + + ++LR ++ K + K + + AK+++ LK +HQ L +
Sbjct: 1779 AHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELK-ANEHQLITLKK 1837
Query: 562 TSLKLQEKASESD---AEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQ 618
+ Q+K SE + +IKD T+ +LE + + A KLH N + E++ SV+K +
Sbjct: 1838 DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIE-NLNLAQKLHEN--LEEMK-SVMKERDN 1893
Query: 619 KSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEK 678
+E LK Q+KE +E + ++Q + A + E ++ + ++ K+ E+ +
Sbjct: 1894 LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQ 1953
Query: 679 NARLQKEL 686
+ +QK+L
Sbjct: 1954 ISDIQKDL 1961
Score = 72.0 bits (175), Expect = 2e-12
Identities = 138/701 (19%), Positives = 283/701 (40%), Gaps = 119/701 (16%)
Query: 81 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 140
EK + ++++ L E K E + +LK+ +E + D L ++ T D
Sbjct: 909 EKTLITEKLQQTLEEVKTLTQE----KDDLKQLQESLQIER---DQLKSDIHDTVNMNID 961
Query: 141 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQ 200
T+ +R E K Q+ ++ L+ + + E++ H + G I +
Sbjct: 962 TQEQLRNALESLKQHQETINTLKSK---ISEEVSRNLHMEENTGETKDEFQQKM-VGIDK 1017
Query: 201 ESSFGSPTGNQMSSDID-----EYKKNIHG-----NALRTSGSSSSDVTKASLSPDASDF 250
+ + +++D+ E ++ I N L+ S K L D +
Sbjct: 1018 KQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQM-LESVIAEKEQLKTDLKEN 1076
Query: 251 EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVS---ELS-----LASLTEKIQKMEEN 302
+T E L + K + A +++ ELS LA + EK+++ +
Sbjct: 1077 IEMTIENQEE-LRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQ 1135
Query: 303 HHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL 362
++L +E+S+ Q+ + E+ +L +++ LE + E A++L++ E++
Sbjct: 1136 LQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEV 1195
Query: 363 MNLLQERVKNEE------------------------PTTQEGKI--IELEQKCTGILEQG 396
++ +ER +E T +E KI I L++ I E
Sbjct: 1196 KSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELR 1255
Query: 397 RFEREKLLNI--QQQLTCSLRKVEE------ENQGALEMIKRLKEENEKLNEF------- 441
R EK I Q L S K++E E Q L +K + E E +NE
Sbjct: 1256 RSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQS 1315
Query: 442 ----------LELERHNNN-----------MMAKTLEECRVTLEGLKMENGSLKSHLQGE 480
+E+ER N + K + + E L++++ LK H++
Sbjct: 1316 TTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRET 1375
Query: 481 KQKATEASAVEQTAESCE---------VQEMLKVARAEKDLL--ELSCNELRQELLKANG 529
K E+ + ++ + + + V EM + + LL E+ L + L +++
Sbjct: 1376 LAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHD 1435
Query: 530 EIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELED 589
E+K V AK + D L+E+ +++QL ++ K E++ E+K + E E+
Sbjct: 1436 EMKSV----AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEE 1491
Query: 590 QVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQ-ADLQ 648
+ + R +SE E+ + +++Q + +L+ +++ E+ E++ Q +++Q
Sbjct: 1492 TINELRV-------NLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQ 1544
Query: 649 TAVVVANDIKCEAQQE---LRTVKRKLLEEEEKNARLQKEL 686
V K + + L++++ K+LE + Q+E+
Sbjct: 1545 EKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI 1585
Score = 70.5 bits (171), Expect = 5e-12
Identities = 83/393 (21%), Positives = 176/393 (44%), Gaps = 53/393 (13%)
Query: 308 EELQATLQELSDQQQMVQ-ELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLL 366
+EL T +++ + Q+ Q +L A+ + VD + L+++F+ E KL +L+
Sbjct: 656 KELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFN-----------EITKLTSLI 704
Query: 367 QERVKNEEPTTQE--GKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGA 424
+V + E GKI +L+++ +E+ RE+++ L L+ + E
Sbjct: 705 DGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVI-----LLSELKSLPSE---- 755
Query: 425 LEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKA 484
++RL++E + +E L + + + + ++GL E G K L A
Sbjct: 756 ---VERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL------A 806
Query: 485 TEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE-LRQELLKANGEIKHVSSLLAKVEK 543
T S + T + + + L + +K + L NE + QE++ + E + S L ++
Sbjct: 807 TTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKT 866
Query: 544 DYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQ 603
+ SY + +LQEK E + +M++ +LE++ + V+
Sbjct: 867 ELSYKTQ--------------ELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTL 912
Query: 604 LISELESS---VIKLEEQKSDLERQLKTLT---KQMKEETEEWRRFQADLQTAVVVANDI 657
+ +L+ + V L ++K DL++ ++L Q+K + + D Q + A +
Sbjct: 913 ITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALES 972
Query: 658 KCEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 690
+ Q+ + T+K K+ EE +N +++ G+ +
Sbjct: 973 LKQHQETINTLKSKISEEVSRNLHMEENTGETK 1005
Score = 67.8 bits (164), Expect = 3e-11
Identities = 90/431 (20%), Positives = 190/431 (44%), Gaps = 65/431 (15%)
Query: 305 STAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRE-RAEQLSQENEKLM 363
S E++ +E+ D+ + + +T+E +KL E H+E R + L +E K
Sbjct: 751 SLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVV--------HKESRVQGLLEEIGKTK 802
Query: 364 NLLQERVKNEEPTTQEGKI-----IELEQKCTGILEQGRFEREKLLNIQ---QQLTCSLR 415
+ L N + T QE + ++ EQK +LE+ ++++N+ Q+ SL
Sbjct: 803 DDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLG 862
Query: 416 KVEEE-NQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 474
++ E + E+ ++ +E E+LNE +L+ LE TL+ ++ E +
Sbjct: 863 ALKTELSYKTQELQEKTREVQERLNEMEQLKEQ--------LENRDSTLQTVEREKTLIT 914
Query: 475 SHLQGEKQKATEASAVEQTAESC-EVQEMLKVARAE-----KDLLELSCN---ELRQELL 525
LQ Q E + Q + ++QE L++ R + D + ++ + +LR L
Sbjct: 915 EKLQ---QTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971
Query: 526 KANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIF 585
+ +++L +K+ ++ S + ++ E K+ + D E K+ +
Sbjct: 972 SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTA 1031
Query: 586 ELEDQ--VEQHRAVKL---HNNQLISELESSVIKLEEQKSDL----------ERQLKTLT 630
+++D +EQ R + N+L LES + + E+ K+DL + +L+ L
Sbjct: 1032 DVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLG 1091
Query: 631 KQMKEETE-----------EWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKN 679
++K++ E + V +K E Q+L+ +++LL +E+
Sbjct: 1092 DELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLK-EKSQQLQEKQQQLLNVQEEM 1150
Query: 680 ARLQKELGDVQ 690
+ +QK++ +++
Sbjct: 1151 SEMQKKINEIE 1161
Score = 60.1 bits (144), Expect = 7e-09
Identities = 87/420 (20%), Positives = 187/420 (44%), Gaps = 42/420 (10%)
Query: 286 ELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSF 345
E S A L EKIQ+++ N H +L +++++ Q+ V E+ +++ D+ L
Sbjct: 1812 ENSNAKLQEKIQELKANEH----QLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLE 1867
Query: 346 HQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLN 405
++ A++L + E++ ++++ER + +E +E +Q + E + + + L
Sbjct: 1868 IENLNLAQKLHENLEEMKSVMKER--DNLRRVEETLKLERDQ----LKESLQETKARDLE 1921
Query: 406 IQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEF-LELERHNNNMMAKTLEECRVTLE 464
IQQ+L + +E + ++ +++ E+ ++++ +L++ + + K E + L+
Sbjct: 1922 IQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQ 1981
Query: 465 GLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEM-LKVARAEKDLLELSCNELRQE 523
L+++ SH + + +EQ + E Q + ++ R + L +E +E
Sbjct: 1982 LLRVKEDVNMSH--------KKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEE 2033
Query: 524 L---LKANGEIKHVSSLLAKVEKD--YSYLKEIC--DHQAEQ-------LSRTSLKLQEK 569
+ K E++ + L K+E+D + L+E+ D Q Q LS L E
Sbjct: 2034 IRIVAKERDELRRIKESL-KMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTES 2092
Query: 570 ASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTL 629
E + IK++ + E++D E + L + I + ++++ S Q K +
Sbjct: 2093 LREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHI 2152
Query: 630 TKQMKEE---TEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKEL 686
K + E+ R L+ + IK E + + + ++E EK QKEL
Sbjct: 2153 EKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEK----QKEL 2208
Score = 54.3 bits (129), Expect = 4e-07
Identities = 95/452 (21%), Positives = 195/452 (43%), Gaps = 44/452 (9%)
Query: 272 SKCSTAGSSPNSVSELSLASLTEKIQKM-EENHHSTAEELQATLQEL--------SDQQQ 322
S CS + N++ LS + + +EN S L+A L +++++
Sbjct: 464 SVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEE 523
Query: 323 MVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQE-RVKNEEPTTQEGK 381
M +L +N+ +DE LE + +E QL E L NL++ V N++ +
Sbjct: 524 MELKLKEKND--LDEFEALERKTKKDQEM--QLIHEISNLKNLVKHAEVYNQDLENELSS 579
Query: 382 IIELEQKCTGILE--QGRFEREKLLNIQQQLTCSLRKVEEENQGALEMI---------KR 430
+EL ++ ++ Q + +KL NI+ L+ SL +E+ Q + KR
Sbjct: 580 KVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKR 639
Query: 431 ----LKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATE 486
L+ EN +L E ++ M ++ + LE K L+ LQ + T+
Sbjct: 640 ESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITK 699
Query: 487 ASAVEQTAES----CEVQEMLKVARAEKDL-LELSCNE-LRQELLKANGEIKHVSSLLAK 540
+++ C ++ K+ +K+L E+ NE LR+E++ + + SL ++
Sbjct: 700 LTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVIL----LSELKSLPSE 755
Query: 541 VEKDYSYLKEICDHQAEQLSRTSL--KLQEKASESDAEIKDMKETIFELEDQVEQHRAVK 598
VE+ KEI D E TS KL + ++ ++ + E I + +D + ++
Sbjct: 756 VER---LRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNY 812
Query: 599 LHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIK 658
+Q ++ + E++ + + + + +++ ++E ++F + L +
Sbjct: 813 KSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKT 872
Query: 659 CEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 690
E Q++ R V+ +L E E+ +L+ +Q
Sbjct: 873 QELQEKTREVQERLNEMEQLKEQLENRDSTLQ 904
Score = 46.2 bits (108), Expect = 1e-04
Identities = 74/364 (20%), Positives = 146/364 (40%), Gaps = 50/364 (13%)
Query: 296 IQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQL 355
+ K++E H + + + + E+ + E L+ + + + RE +
Sbjct: 2180 VTKIKEEQHESINKFE---------MDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLK 2230
Query: 356 SQENEKLM--NLLQERVKNEEPT--TQEGKIIELEQKCTGILEQG---RFEREKLLNIQQ 408
+N L +L++ ++E P+ T+ +++ ++ T LE+ RF+ EKL N Q
Sbjct: 2231 LNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQ 2290
Query: 409 QLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKM 468
+ + +V + I +NE E E + A +E L+ LK
Sbjct: 2291 KENDRICQVNNFFNNRIIAI---------MNESTEFEERS----ATISKEWEQDLKSLKE 2337
Query: 469 ENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKAN 528
+N L + Q K + V T + + V L EL L +A
Sbjct: 2338 KNEKLFKNYQTLKTSLASGAQVNPTTQD---NKNPHVTSRATQLTTEKIRELENSLHEAK 2394
Query: 529 GEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELE 588
H S + K++K+ +I KLQ K ES+ ++ KETI L+
Sbjct: 2395 ESAMHKESKIIKMQKELEVTNDII-----------AKLQAKVHESNKCLEKTKETIQVLQ 2443
Query: 589 DQVEQHRAVKLHNNQLISELESSVIKLEEQK----SDLERQLKTLTKQMKEETEEWRRFQ 644
D+V K + + I +L+ ++K++ +K + E+++ ++ + E R +
Sbjct: 2444 DKVA--LGAKPYKEE-IEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLR 2500
Query: 645 ADLQ 648
+L+
Sbjct: 2501 ENLR 2504
Score = 36.2 bits (82), Expect = 0.11
Identities = 86/423 (20%), Positives = 157/423 (37%), Gaps = 71/423 (16%)
Query: 323 MVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKI 382
+ +E+ +E + T E S H + Q S + + ++ E + EP+ EG +
Sbjct: 167 LTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSV 226
Query: 383 IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGAL---EMIKRLKE------ 433
+ R + ++ + C++ N+ ++IK+L +
Sbjct: 227 KVSHLNLVDLAGSERAAQTGAAGVRLKEGCNI------NRSLFILGQVIKKLSDGQVGGF 280
Query: 434 ---ENEKLNEFLELERHNNNMMAKTLEECRVT---------------------------- 462
+ KL L+ N AKT C +T
Sbjct: 281 INYRDSKLTRILQNSLGGN---AKTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNE 337
Query: 463 -------LEGLKMENGSLKSHLQGEKQKATEASAVE--QTAESCEVQEMLKVARAEK--- 510
L+ + E LK L+ E T A A+E Q A+ E +++L+ + EK
Sbjct: 338 VSTDEALLKRYRKEIMDLKKQLE-EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIEN 396
Query: 511 --DLLELSCNELRQELLKANGEIKHVSSLLAKVEK----DYSYLKEICDHQAEQLSRTSL 564
+L S + Q+ LKA + + V+ L K+ K +Y+ I + + + S+
Sbjct: 397 LTRMLVTSSSLTLQQELKAKRK-RRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSI 455
Query: 565 KLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLI-SELESSVIKLEEQKSDLE 623
L + ES D+ + ++E + A KL N + I SEL S + D E
Sbjct: 456 NLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYE 515
Query: 624 RQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQ 683
QL+T ++M+ + +E D + + E+ +K + E N L+
Sbjct: 516 -QLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLE 574
Query: 684 KEL 686
EL
Sbjct: 575 NEL 577
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 92.8 bits (229), Expect = 1e-18
Identities = 139/617 (22%), Positives = 252/617 (40%), Gaps = 103/617 (16%)
Query: 140 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN---------SEGA--ASH 188
+TE + ++E+ + + EL+ E + + L+EK++ L N +EG A
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 189 TGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 248
D T I E+ T + + D +E NA T+ + + L D
Sbjct: 910 RCDQLIKTKIQLEAKIKEVT--ERAEDEEEI------NAELTAKKRKLEDECSELKKDID 961
Query: 249 DFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAE 308
D E +T + +T N K+ AG + ++A LT++ + ++E H T +
Sbjct: 962 DLE-LTLAKVEKEKHATENKVKNLTEEMAG------LDETIAKLTKEKKALQEAHQQTLD 1014
Query: 309 ELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL---MNL 365
+LQA ++ V LT KL + LE S Q ++ L + KL + L
Sbjct: 1015 DLQA-------EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL 1067
Query: 366 LQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGAL 425
QE + + E Q +L++K L++ FE + N+Q K+E+E +
Sbjct: 1068 AQESIMDIENEKQ-----QLDEK----LKKKEFE---ISNLQS-------KIEDEQALGI 1108
Query: 426 EMIKRLKE---ENEKLNEFLELER-------HNNNMMAKTLEECRVTLEGLKMENGSLKS 475
++ K++KE E+L E +E ER + +++ LEE E L+ G+ +
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS---ERLEEAGGATSA 1165
Query: 476 HLQGEKQKATEASAVEQTAESCEVQEMLKVARAEK-------------DLLELSCNELRQ 522
++ K++ E + + E +Q A K D L+ +L +
Sbjct: 1166 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225
Query: 523 ELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKE 582
E + EI ++S + V K L+++C +QLS +L+ K E I D+
Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLS----ELKSKEEEQQRLINDLTA 1281
Query: 583 TIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ---------- 632
L+ + + L+S+L +Q +L+RQL+ K
Sbjct: 1282 QRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQS 1341
Query: 633 -------MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEE-EEKNARLQK 684
++E+ EE + +A+LQ A+ AN + + + T + EE EE +L +
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1401
Query: 685 ELGDVQGHGRVVTSRAA 701
L + H V ++ A
Sbjct: 1402 RLQAAEEHVEAVNAKCA 1418
Score = 81.3 bits (199), Expect = 3e-15
Identities = 137/633 (21%), Positives = 254/633 (40%), Gaps = 81/633 (12%)
Query: 81 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 140
EK AL+ ++ L + +A++ ++N L K +++ D L +++ D
Sbjct: 1001 EKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQ-------VDDLEGSLEQEKKLRMD 1053
Query: 141 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQ 200
E R LE K Q+ + D+E E + L EKL E S+ + I
Sbjct: 1054 LERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEI-----------SNLQSKIED 1102
Query: 201 ESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSR 260
E + G Q+ I E + I +S +A SD SR
Sbjct: 1103 EQALGI----QLQKKIKELQARIEELEEEIEAERAS---RAKAEKQRSDL--------SR 1147
Query: 261 PLSSTSNPFKSSKCSTAGS-SPNSVSELSLASLTEKIQKMEENHHSTAEELQAT-LQELS 318
L S + + +T+ N E + +++ H +TA L+ ++
Sbjct: 1148 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVA 1207
Query: 319 DQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQEN---EKLMNLLQERVKNEEP 375
+ + + L +KL EK+ ++ E +S+ EK+ L++++ +
Sbjct: 1208 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS 1267
Query: 376 TTQEGKIIELE---QKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLK 432
+E + + + Q+ E G F R+ L+ ++ L L + ++ +E +KR
Sbjct: 1268 KEEEQQRLINDLTAQRGRLQTESGEFSRQ--LDEKEALVSQLSRGKQAFTQQIEELKRQL 1325
Query: 433 EENEK----LNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKA-TEA 487
EE K L L+ RH+ +++ + EE + + K+ LQ KA TE
Sbjct: 1326 EEEIKAKNALAHALQSSRHDCDLLREQYEEEQES-----------KAELQRALSKANTEV 1374
Query: 488 SAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSY 547
+ E+ +Q ++ A+K +L Q L A ++ V++ A +EK
Sbjct: 1375 AQWRTKYETDAIQRTEELEEAKK--------KLAQRLQAAEEHVEAVNAKCASLEKTKQR 1426
Query: 548 LKEICDHQAEQLSRTSLK---LQEKASESDAEIKDMK----ETIFELEDQVEQHRAVKLH 600
L+ + + RT+ L +K D + + K ET ELE ++ R++
Sbjct: 1427 LQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTE 1486
Query: 601 NNQLISELESSVIKLEEQKSD---LERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDI 657
++ + E S+ +LE K + L++++ LT+Q+ E + +L+
Sbjct: 1487 LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH----ELEKIKKQVEQE 1542
Query: 658 KCEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 690
KCE Q L + L EE K R+Q EL V+
Sbjct: 1543 KCELQAALEEAEASLEHEEGKILRIQLELNQVK 1575
Score = 76.3 bits (186), Expect = 9e-14
Identities = 133/640 (20%), Positives = 251/640 (39%), Gaps = 94/640 (14%)
Query: 64 KHLRTPSTKPKQENEGGEKAA------LESQVRELLAEAKAKDSEINRLRSELKKYKEKR 117
K LR + K++ EG K A +E++ ++L + K K+ EI+ L+S K ++++
Sbjct: 1048 KKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS---KIEDEQ 1104
Query: 118 TLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLE 177
L + L + + E I A +K+ SDL E + E+L
Sbjct: 1105 ALGIQ----LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL---- 1156
Query: 178 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSD 237
+ GA S + + +E+ F +M D++E A +
Sbjct: 1157 --EEAGGATS----AQIEMNKKREAEF-----QKMRRDLEEATLQHEATAATLRKKHADS 1205
Query: 238 VTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQ 297
V A L + + + + S + LAS E +
Sbjct: 1206 V--AELGEQIDNLQRVKQKLEKE------------------KSEMKMEIDDLASNVETVS 1245
Query: 298 KMEENHHSTAEELQATLQELS----DQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 353
K + N L+ L EL +QQ+++ +LTA+ +L E +
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVS 1305
Query: 354 QLS-------QENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNI 406
QLS Q+ E+L L+E +K + + C + EQ E+E +
Sbjct: 1306 QLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA--LQSSRHDCDLLREQYEEEQESKAEL 1363
Query: 407 QQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGL 466
Q+ L+ + +V + R K E + + ELE + A+ L+ +E +
Sbjct: 1364 QRALSKANTEVAQW---------RTKYETDAIQRTEELEEAKKKL-AQRLQAAEEHVEAV 1413
Query: 467 KMENGSLKSHLQGEKQKATEASA-VEQTAESCEVQEMLKVARAEKDLLELS--CNELRQE 523
+ SL+ Q + + + VE+T +C + K +K L E C E E
Sbjct: 1414 NAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK-KQRNFDKILAEWKQKCEETHAE 1472
Query: 524 LLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKET 583
L + E + + + L K++ Y +E D Q E L R + LQ++ S+ +I + +
Sbjct: 1473 LEASQKEARSLGTELFKIKNAY---EESLD-QLETLKRENKNLQQEISDLTEQIAEGGKR 1528
Query: 584 IFELEDQVEQHRAVKLHNNQLISELESSV-----------IKLEEQKSDLERQLKTLTKQ 632
I ELE +Q K + E E+S+ ++L + KS+++R++ +
Sbjct: 1529 IHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI----AE 1584
Query: 633 MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKL 672
EE ++ +R + ++ D + ++ + +K+K+
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKM 1624
Score = 73.9 bits (180), Expect = 5e-13
Identities = 95/406 (23%), Positives = 175/406 (43%), Gaps = 60/406 (14%)
Query: 295 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 354
K + E+ + EE Q EL+ + +EL + L+ EK L+ Q + AE
Sbjct: 847 KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL---QVQAEAEG 903
Query: 355 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 414
L+ E+ L++ + I+LE K + E+ E E I +LT
Sbjct: 904 LADAEERCDQLIKTK-------------IQLEAKIKEVTERAEDEEE----INAELTAKK 946
Query: 415 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 474
RK+E+E +K+ ++ E +E E+H K L E L+ + K
Sbjct: 947 RKLEDE----CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK 1002
Query: 475 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDL---LELSCNELRQELLKAN--- 528
LQ Q+ + E+ + + +K+ + DL LE +LR +L +A
Sbjct: 1003 KALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE-KKLRMDLERAKRKL 1061
Query: 529 -GEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKAS---ESDAEIKDMKETI 584
G++K + +E + L E + ++S K++++ + + +IK+++ I
Sbjct: 1062 EGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI 1121
Query: 585 FELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQ 644
ELE+++E RA S K E+Q+SDL R+L+ ++++++E
Sbjct: 1122 EELEEEIEAERA--------------SRAKAEKQRSDLSRELEEISERLEE--------- 1158
Query: 645 ADLQTAVVVANDIKCEA--QQELRTVKRKLLEEEEKNARLQKELGD 688
A T+ + + K EA Q+ R ++ L+ E A L+K+ D
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Score = 62.8 bits (151), Expect = 1e-09
Identities = 75/303 (24%), Positives = 133/303 (43%), Gaps = 56/303 (18%)
Query: 414 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 473
L+ E E + A +KEE +K+ + E + K LEE VTL LK +N L
Sbjct: 846 LKSAETEKEMAT-----MKEEFQKIKD----ELAKSEAKRKELEEKMVTL--LKEKN-DL 893
Query: 474 KSHLQGEKQKATEA---------------SAVEQTAESCEVQEMLKVA-RAEKDLLELSC 517
+ +Q E + +A + +++ E E +E + A+K LE C
Sbjct: 894 QLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 953
Query: 518 NELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEI 577
+EL+++ I + LAKVEK+ K +++ + L+ L E ++ E
Sbjct: 954 SELKKD-------IDDLELTLAKVEKE----KHATENKVKNLTEEMAGLDETIAKLTKEK 1002
Query: 578 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 637
K ++E + D ++ ++ L + IKLE+Q DLE L+ K +
Sbjct: 1003 KALQEAHQQTLDDLQAEE-------DKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1055
Query: 638 EEWRRFQADLQTAVVVANDIKCEAQQ----------ELRTVKRKLLEEEEKNARLQKELG 687
R+ + DL+ A DI+ E QQ E+ ++ K+ +E+ +LQK++
Sbjct: 1056 RAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIK 1115
Query: 688 DVQ 690
++Q
Sbjct: 1116 ELQ 1118
Score = 58.9 bits (141), Expect = 2e-08
Identities = 125/634 (19%), Positives = 235/634 (37%), Gaps = 111/634 (17%)
Query: 48 RKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEA-KAKDSEINRL 106
++++S + TK+ + ++ E +K A Q E EA AK + + +
Sbjct: 1364 QRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT 1423
Query: 107 RSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEEN 166
+ L+ E L+ E T+A AL++K +NF K L++ +++
Sbjct: 1424 KQRLQNEVEDLMLDVERTNAA-----------------CAALDKKQRNFDKILAEWKQKC 1466
Query: 167 RVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGN------QMSSDIDEYK 220
+L + S G ++ S+ Q + N ++ I E
Sbjct: 1467 EETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGG 1526
Query: 221 KNIHG-NALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS 279
K IH ++ +A+L + EH E + N KS
Sbjct: 1527 KRIHELEKIKKQVEQEKCELQAALEEAEASLEH--EEGKILRIQLELNQVKSEV------ 1578
Query: 280 SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQ---------------------ELS 318
+ +A E+I +++ NH E +Q+TL E+
Sbjct: 1579 ------DRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1632
Query: 319 DQQQMVQELTAENEK--------LVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERV 370
Q + AE + L D + L+ + + EQL+ E+ NLLQ +
Sbjct: 1633 IQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV-ERRANLLQAEI 1691
Query: 371 KNEEPTTQEGKIIELEQKCTGILEQGRF---EREKLLNIQQQLTCSLRKVEEENQGALEM 427
+ T +E ++ I EQ ER +LL+ Q + +K E +
Sbjct: 1692 EELRAT------LEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD------ 1739
Query: 428 IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEA 487
+ + ++ + L+ R+ K + + + E LK E + +HL+ K+
Sbjct: 1740 ---ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDT-SAHLERMKKN---- 1791
Query: 488 SAVEQTAESCEV------QEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKV 541
+EQT + ++ Q LK + + LE EL E+ E K + + +
Sbjct: 1792 --MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEV---ESEQKRNAEAVKGL 1846
Query: 542 EKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHN 601
K +KE+ +Q E+ + L+LQ+ + A++K K E E+Q + A
Sbjct: 1847 RKHERRVKELT-YQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLA----- 1900
Query: 602 NQLISELESSVIKLEEQKSDLERQLKTLTKQMKE 635
+L+ + + EE+ E Q+ L + +E
Sbjct: 1901 --KFRKLQHELEEAEERADIAESQVNKLRVKSRE 1932
Score = 58.5 bits (140), Expect = 2e-08
Identities = 126/652 (19%), Positives = 259/652 (39%), Gaps = 88/652 (13%)
Query: 85 LESQVRELLAEAKAKDSEINRLRSEL-------KKYKEKRTLNAEGTDALGPNVDGTSVS 137
+E R+L E KAK++ + L+S ++Y+E++ AE AL T V+
Sbjct: 1318 IEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKA--NTEVA 1375
Query: 138 PGDTEPMIRA------LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGD 191
T+ A LEE K + L EE + K LE + + + D
Sbjct: 1376 QWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT--KQRLQNEVED 1433
Query: 192 SSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFE 251
T N + +D+ ++N + + + T A L +
Sbjct: 1434 LMLDVERT----------NAACAALDKKQRNF--DKILAEWKQKCEETHAELEASQKEAR 1481
Query: 252 HITAETPSRPLSSTSNPFKSSKCSTAG-SSPNSVSELSLASLTEKIQKMEENHHSTAEEL 310
+ E L N ++ S N + ++ LTE+I + + H +
Sbjct: 1482 SLGTE-----LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIK 1536
Query: 311 QATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE---QLSQENEKLMNLLQ 367
+ QE + Q ++E A E +E IL ++ ++E ++++++E++ L +
Sbjct: 1537 KQVEQEKCELQAALEEAEASLEH--EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR 1594
Query: 368 ERVKNEEP--TTQEGKI------IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEE 419
++ E +T + +I I L++K G L E E LN ++ +
Sbjct: 1595 NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN----EMEIQLNHANRMAAEALRNYR 1650
Query: 420 ENQGALE----MIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKS 475
QG L+ + E L E L + N++ +EE R TLE + +
Sbjct: 1651 NTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1710
Query: 476 HLQGEKQKA----TEASAVEQTAESCE---------VQEMLKVARAEKDLLELSCNE--- 519
L ++ T+ +++ T + E ++++L+ AR ++ + + +
Sbjct: 1711 ELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAM 1770
Query: 520 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLS-----RTSLKLQEKASESD 574
+ +EL K H+ + +E+ L+ D +AEQL+ + KL+ + E +
Sbjct: 1771 MAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLD-EAEQLALKGGKKQIQKLEARVRELE 1829
Query: 575 AEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK 634
E++ ++ E + +H E ++++L++ L+ ++K+ +Q +
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1889
Query: 635 EETEE-------WRRFQADLQTAVVVANDIKCEAQQ---ELRTVKRKLLEEE 676
E E+ +R+ Q +L+ A A+ + + + + R V K++ EE
Sbjct: 1890 EAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 92.8 bits (229), Expect = 1e-18
Identities = 139/617 (22%), Positives = 252/617 (40%), Gaps = 103/617 (16%)
Query: 140 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN---------SEGA--ASH 188
+TE + ++E+ + + EL+ E + + L+EK++ L N +EG A
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 189 TGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 248
D T I E+ T + + D +E NA T+ + + L D
Sbjct: 910 RCDQLIKTKIQLEAKIKEVT--ERAEDEEEI------NAELTAKKRKLEDECSELKKDID 961
Query: 249 DFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAE 308
D E +T + +T N K+ AG + ++A LT++ + ++E H T +
Sbjct: 962 DLE-LTLAKVEKEKHATENKVKNLTEEMAG------LDETIAKLTKEKKALQEAHQQTLD 1014
Query: 309 ELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL---MNL 365
+LQA ++ V LT KL + LE S Q ++ L + KL + L
Sbjct: 1015 DLQA-------EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL 1067
Query: 366 LQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGAL 425
QE + + E Q +L++K L++ FE + N+Q K+E+E +
Sbjct: 1068 AQESIMDIENEKQ-----QLDEK----LKKKEFE---ISNLQS-------KIEDEQALGI 1108
Query: 426 EMIKRLKE---ENEKLNEFLELER-------HNNNMMAKTLEECRVTLEGLKMENGSLKS 475
++ K++KE E+L E +E ER + +++ LEE E L+ G+ +
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS---ERLEEAGGATSA 1165
Query: 476 HLQGEKQKATEASAVEQTAESCEVQEMLKVARAEK-------------DLLELSCNELRQ 522
++ K++ E + + E +Q A K D L+ +L +
Sbjct: 1166 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225
Query: 523 ELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKE 582
E + EI ++S + V K L+++C +QLS +L+ K E I D+
Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLS----ELKSKEEEQQRLINDLTA 1281
Query: 583 TIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ---------- 632
L+ + + L+S+L +Q +L+RQL+ K
Sbjct: 1282 QRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQS 1341
Query: 633 -------MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEE-EEKNARLQK 684
++E+ EE + +A+LQ A+ AN + + + T + EE EE +L +
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1401
Query: 685 ELGDVQGHGRVVTSRAA 701
L + H V ++ A
Sbjct: 1402 RLQAAEEHVEAVNAKCA 1418
Score = 81.3 bits (199), Expect = 3e-15
Identities = 137/633 (21%), Positives = 254/633 (40%), Gaps = 81/633 (12%)
Query: 81 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 140
EK AL+ ++ L + +A++ ++N L K +++ D L +++ D
Sbjct: 1001 EKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQ-------VDDLEGSLEQEKKLRMD 1053
Query: 141 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQ 200
E R LE K Q+ + D+E E + L EKL E S+ + I
Sbjct: 1054 LERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEI-----------SNLQSKIED 1102
Query: 201 ESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSR 260
E + G Q+ I E + I +S +A SD SR
Sbjct: 1103 EQALGI----QLQKKIKELQARIEELEEEIEAERAS---RAKAEKQRSDL--------SR 1147
Query: 261 PLSSTSNPFKSSKCSTAGS-SPNSVSELSLASLTEKIQKMEENHHSTAEELQAT-LQELS 318
L S + + +T+ N E + +++ H +TA L+ ++
Sbjct: 1148 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVA 1207
Query: 319 DQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQEN---EKLMNLLQERVKNEEP 375
+ + + L +KL EK+ ++ E +S+ EK+ L++++ +
Sbjct: 1208 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS 1267
Query: 376 TTQEGKIIELE---QKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLK 432
+E + + + Q+ E G F R+ L+ ++ L L + ++ +E +KR
Sbjct: 1268 KEEEQQRLINDLTAQRGRLQTESGEFSRQ--LDEKEALVSQLSRGKQAFTQQIEELKRQL 1325
Query: 433 EENEK----LNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKA-TEA 487
EE K L L+ RH+ +++ + EE + + K+ LQ KA TE
Sbjct: 1326 EEEIKAKNALAHALQSSRHDCDLLREQYEEEQES-----------KAELQRALSKANTEV 1374
Query: 488 SAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSY 547
+ E+ +Q ++ A+K +L Q L A ++ V++ A +EK
Sbjct: 1375 AQWRTKYETDAIQRTEELEEAKK--------KLAQRLQAAEEHVEAVNAKCASLEKTKQR 1426
Query: 548 LKEICDHQAEQLSRTSLK---LQEKASESDAEIKDMK----ETIFELEDQVEQHRAVKLH 600
L+ + + RT+ L +K D + + K ET ELE ++ R++
Sbjct: 1427 LQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTE 1486
Query: 601 NNQLISELESSVIKLEEQKSD---LERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDI 657
++ + E S+ +LE K + L++++ LT+Q+ E + +L+
Sbjct: 1487 LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH----ELEKIKKQVEQE 1542
Query: 658 KCEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 690
KCE Q L + L EE K R+Q EL V+
Sbjct: 1543 KCELQAALEEAEASLEHEEGKILRIQLELNQVK 1575
Score = 76.3 bits (186), Expect = 9e-14
Identities = 133/640 (20%), Positives = 251/640 (39%), Gaps = 94/640 (14%)
Query: 64 KHLRTPSTKPKQENEGGEKAA------LESQVRELLAEAKAKDSEINRLRSELKKYKEKR 117
K LR + K++ EG K A +E++ ++L + K K+ EI+ L+S K ++++
Sbjct: 1048 KKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS---KIEDEQ 1104
Query: 118 TLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLE 177
L + L + + E I A +K+ SDL E + E+L
Sbjct: 1105 ALGIQ----LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL---- 1156
Query: 178 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSD 237
+ GA S + + +E+ F +M D++E A +
Sbjct: 1157 --EEAGGATS----AQIEMNKKREAEF-----QKMRRDLEEATLQHEATAATLRKKHADS 1205
Query: 238 VTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQ 297
V A L + + + + S + LAS E +
Sbjct: 1206 V--AELGEQIDNLQRVKQKLEKE------------------KSEMKMEIDDLASNVETVS 1245
Query: 298 KMEENHHSTAEELQATLQELS----DQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 353
K + N L+ L EL +QQ+++ +LTA+ +L E +
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVS 1305
Query: 354 QLS-------QENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNI 406
QLS Q+ E+L L+E +K + + C + EQ E+E +
Sbjct: 1306 QLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA--LQSSRHDCDLLREQYEEEQESKAEL 1363
Query: 407 QQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGL 466
Q+ L+ + +V + R K E + + ELE + A+ L+ +E +
Sbjct: 1364 QRALSKANTEVAQW---------RTKYETDAIQRTEELEEAKKKL-AQRLQAAEEHVEAV 1413
Query: 467 KMENGSLKSHLQGEKQKATEASA-VEQTAESCEVQEMLKVARAEKDLLELS--CNELRQE 523
+ SL+ Q + + + VE+T +C + K +K L E C E E
Sbjct: 1414 NAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK-KQRNFDKILAEWKQKCEETHAE 1472
Query: 524 LLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKET 583
L + E + + + L K++ Y +E D Q E L R + LQ++ S+ +I + +
Sbjct: 1473 LEASQKEARSLGTELFKIKNAY---EESLD-QLETLKRENKNLQQEISDLTEQIAEGGKR 1528
Query: 584 IFELEDQVEQHRAVKLHNNQLISELESSV-----------IKLEEQKSDLERQLKTLTKQ 632
I ELE +Q K + E E+S+ ++L + KS+++R++ +
Sbjct: 1529 IHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI----AE 1584
Query: 633 MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKL 672
EE ++ +R + ++ D + ++ + +K+K+
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKM 1624
Score = 73.9 bits (180), Expect = 5e-13
Identities = 95/406 (23%), Positives = 175/406 (43%), Gaps = 60/406 (14%)
Query: 295 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 354
K + E+ + EE Q EL+ + +EL + L+ EK L+ Q + AE
Sbjct: 847 KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL---QVQAEAEG 903
Query: 355 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 414
L+ E+ L++ + I+LE K + E+ E E I +LT
Sbjct: 904 LADAEERCDQLIKTK-------------IQLEAKIKEVTERAEDEEE----INAELTAKK 946
Query: 415 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 474
RK+E+E +K+ ++ E +E E+H K L E L+ + K
Sbjct: 947 RKLEDE----CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK 1002
Query: 475 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDL---LELSCNELRQELLKAN--- 528
LQ Q+ + E+ + + +K+ + DL LE +LR +L +A
Sbjct: 1003 KALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE-KKLRMDLERAKRKL 1061
Query: 529 -GEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKAS---ESDAEIKDMKETI 584
G++K + +E + L E + ++S K++++ + + +IK+++ I
Sbjct: 1062 EGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI 1121
Query: 585 FELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQ 644
ELE+++E RA S K E+Q+SDL R+L+ ++++++E
Sbjct: 1122 EELEEEIEAERA--------------SRAKAEKQRSDLSRELEEISERLEE--------- 1158
Query: 645 ADLQTAVVVANDIKCEA--QQELRTVKRKLLEEEEKNARLQKELGD 688
A T+ + + K EA Q+ R ++ L+ E A L+K+ D
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Score = 62.8 bits (151), Expect = 1e-09
Identities = 75/303 (24%), Positives = 133/303 (43%), Gaps = 56/303 (18%)
Query: 414 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 473
L+ E E + A +KEE +K+ + E + K LEE VTL LK +N L
Sbjct: 846 LKSAETEKEMAT-----MKEEFQKIKD----ELAKSEAKRKELEEKMVTL--LKEKN-DL 893
Query: 474 KSHLQGEKQKATEA---------------SAVEQTAESCEVQEMLKVA-RAEKDLLELSC 517
+ +Q E + +A + +++ E E +E + A+K LE C
Sbjct: 894 QLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 953
Query: 518 NELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEI 577
+EL+++ I + LAKVEK+ K +++ + L+ L E ++ E
Sbjct: 954 SELKKD-------IDDLELTLAKVEKE----KHATENKVKNLTEEMAGLDETIAKLTKEK 1002
Query: 578 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 637
K ++E + D ++ ++ L + IKLE+Q DLE L+ K +
Sbjct: 1003 KALQEAHQQTLDDLQAEE-------DKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1055
Query: 638 EEWRRFQADLQTAVVVANDIKCEAQQ----------ELRTVKRKLLEEEEKNARLQKELG 687
R+ + DL+ A DI+ E QQ E+ ++ K+ +E+ +LQK++
Sbjct: 1056 RAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIK 1115
Query: 688 DVQ 690
++Q
Sbjct: 1116 ELQ 1118
Score = 58.9 bits (141), Expect = 2e-08
Identities = 125/634 (19%), Positives = 235/634 (37%), Gaps = 111/634 (17%)
Query: 48 RKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEA-KAKDSEINRL 106
++++S + TK+ + ++ E +K A Q E EA AK + + +
Sbjct: 1364 QRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT 1423
Query: 107 RSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEEN 166
+ L+ E L+ E T+A AL++K +NF K L++ +++
Sbjct: 1424 KQRLQNEVEDLMLDVERTNAA-----------------CAALDKKQRNFDKILAEWKQKC 1466
Query: 167 RVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGN------QMSSDIDEYK 220
+L + S G ++ S+ Q + N ++ I E
Sbjct: 1467 EETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGG 1526
Query: 221 KNIHG-NALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS 279
K IH ++ +A+L + EH E + N KS
Sbjct: 1527 KRIHELEKIKKQVEQEKCELQAALEEAEASLEH--EEGKILRIQLELNQVKSEV------ 1578
Query: 280 SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQ---------------------ELS 318
+ +A E+I +++ NH E +Q+TL E+
Sbjct: 1579 ------DRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1632
Query: 319 DQQQMVQELTAENEK--------LVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERV 370
Q + AE + L D + L+ + + EQL+ E+ NLLQ +
Sbjct: 1633 IQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV-ERRANLLQAEI 1691
Query: 371 KNEEPTTQEGKIIELEQKCTGILEQGRF---EREKLLNIQQQLTCSLRKVEEENQGALEM 427
+ T +E ++ I EQ ER +LL+ Q + +K E +
Sbjct: 1692 EELRAT------LEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD------ 1739
Query: 428 IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEA 487
+ + ++ + L+ R+ K + + + E LK E + +HL+ K+
Sbjct: 1740 ---ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDT-SAHLERMKKN---- 1791
Query: 488 SAVEQTAESCEV------QEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKV 541
+EQT + ++ Q LK + + LE EL E+ E K + + +
Sbjct: 1792 --MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEV---ESEQKRNAEAVKGL 1846
Query: 542 EKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHN 601
K +KE+ +Q E+ + L+LQ+ + A++K K E E+Q + A
Sbjct: 1847 RKHERRVKELT-YQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLA----- 1900
Query: 602 NQLISELESSVIKLEEQKSDLERQLKTLTKQMKE 635
+L+ + + EE+ E Q+ L + +E
Sbjct: 1901 --KFRKLQHELEEAEERADIAESQVNKLRVKSRE 1932
Score = 58.5 bits (140), Expect = 2e-08
Identities = 126/652 (19%), Positives = 259/652 (39%), Gaps = 88/652 (13%)
Query: 85 LESQVRELLAEAKAKDSEINRLRSEL-------KKYKEKRTLNAEGTDALGPNVDGTSVS 137
+E R+L E KAK++ + L+S ++Y+E++ AE AL T V+
Sbjct: 1318 IEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKA--NTEVA 1375
Query: 138 PGDTEPMIRA------LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGD 191
T+ A LEE K + L EE + K LE + + + D
Sbjct: 1376 QWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT--KQRLQNEVED 1433
Query: 192 SSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFE 251
T N + +D+ ++N + + + T A L +
Sbjct: 1434 LMLDVERT----------NAACAALDKKQRNF--DKILAEWKQKCEETHAELEASQKEAR 1481
Query: 252 HITAETPSRPLSSTSNPFKSSKCSTAG-SSPNSVSELSLASLTEKIQKMEENHHSTAEEL 310
+ E L N ++ S N + ++ LTE+I + + H +
Sbjct: 1482 SLGTE-----LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIK 1536
Query: 311 QATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE---QLSQENEKLMNLLQ 367
+ QE + Q ++E A E +E IL ++ ++E ++++++E++ L +
Sbjct: 1537 KQVEQEKCELQAALEEAEASLEH--EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR 1594
Query: 368 ERVKNEEP--TTQEGKI------IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEE 419
++ E +T + +I I L++K G L E E LN ++ +
Sbjct: 1595 NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN----EMEIQLNHANRMAAEALRNYR 1650
Query: 420 ENQGALE----MIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKS 475
QG L+ + E L E L + N++ +EE R TLE + +
Sbjct: 1651 NTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1710
Query: 476 HLQGEKQKA----TEASAVEQTAESCE---------VQEMLKVARAEKDLLELSCNE--- 519
L ++ T+ +++ T + E ++++L+ AR ++ + + +
Sbjct: 1711 ELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAM 1770
Query: 520 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLS-----RTSLKLQEKASESD 574
+ +EL K H+ + +E+ L+ D +AEQL+ + KL+ + E +
Sbjct: 1771 MAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLD-EAEQLALKGGKKQIQKLEARVRELE 1829
Query: 575 AEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK 634
E++ ++ E + +H E ++++L++ L+ ++K+ +Q +
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1889
Query: 635 EETEE-------WRRFQADLQTAVVVANDIKCEAQQ---ELRTVKRKLLEEE 676
E E+ +R+ Q +L+ A A+ + + + + R V K++ EE
Sbjct: 1890 EAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 92.0 bits (227), Expect = 2e-18
Identities = 97/417 (23%), Positives = 188/417 (45%), Gaps = 42/417 (10%)
Query: 296 IQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQL 355
+ K+E+ H+T +++ +E++ +++ +LT E + L + H++ + L
Sbjct: 961 LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA----------HQQALDDL 1010
Query: 356 SQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLR 415
E +K+ L + +VK E+ +E E+K LE+ + + E L + Q+ S+
Sbjct: 1011 QAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE---SIM 1067
Query: 416 KVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGS--- 472
+E + Q E +K+ E LN +E E+ + + K L+E + +E L+ E +
Sbjct: 1068 DLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERT 1127
Query: 473 -------LKSHLQGEKQKATEASAVEQTAESCEVQ-EMLKVARAEKDLLELSCNE--LRQ 522
L+S L E ++ +E +E+ + VQ EM K AE + E L+
Sbjct: 1128 ARAKVEKLRSDLSRELEEISER--LEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH 1185
Query: 523 ELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIK---D 579
E A KH S+ A++ + L+ + ++ S L+L + S + IK +
Sbjct: 1186 EATAAALRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAN 1244
Query: 580 MKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQL-------KTLTKQ 632
+++ LEDQ+ +HR+ + +++L S KL+ + +L RQL LT+
Sbjct: 1245 LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRG 1304
Query: 633 MKEETEEWRRFQADLQTAVVVANDIK---CEAQQELRTVKRKLLEEEEKNARLQKEL 686
T++ + L+ V N + A+ + ++ + EE E A LQ+ L
Sbjct: 1305 KLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVL 1361
Score = 85.5 bits (210), Expect = 2e-16
Identities = 134/621 (21%), Positives = 244/621 (39%), Gaps = 65/621 (10%)
Query: 76 ENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTS 135
E E + LE R+L + K I L ++ ++ E+ +AL ++
Sbjct: 1039 EQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE--- 1095
Query: 136 VSPGDTEPMIRALEEKNKNFQKELSDLEEE---NRVLKEKLIYLEH--SPNSEGAASHTG 190
D + + L++K K Q + +LEEE R + K+ L S E +
Sbjct: 1096 ----DEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE 1151
Query: 191 DSSCPTSITQESSFGSPTGNQ-MSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASD 249
++ TS+ E + Q M D++E A + V A L +
Sbjct: 1152 EAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSV--AELGEQIDN 1209
Query: 250 FEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSV-SELSLASLTEKIQKMEENHHSTAE 308
+ + + L + FK + + ++ +L + ++ H S AE
Sbjct: 1210 LQRV-----KQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAE 1264
Query: 309 ELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQE 368
E Q ++ +L+ Q+ +Q E + +DEK E Q +Q+ E L L+E
Sbjct: 1265 ETQRSVNDLTSQRAKLQTENGELSRQLDEK---EALISQLTRGKLTYTQQLEDLKRQLEE 1321
Query: 369 RVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMI 428
VK + + C + EQ E E +Q+ L+ + +V +
Sbjct: 1322 EVKAKNALAH--ALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ--------- 1370
Query: 429 KRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL---KSHLQGEKQKA- 484
R K E + + ELE +A+ L+E +E + + SL K LQ E +
Sbjct: 1371 WRTKYETDAIQRTEELEEAKKK-LAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1429
Query: 485 --TEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVE 542
E S A + + K+ K E E + EL + E + +S+ L K++
Sbjct: 1430 VDVERSNAAAAALDKKQRNFDKILAEWKQKYE----ESQSELESSQKEARSLSTELFKLK 1485
Query: 543 KDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNN 602
Y +E +H E R + LQE+ S+ ++ +TI ELE +Q A K+
Sbjct: 1486 NAY---EESLEH-LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQ 1541
Query: 603 QLISELESSV-----------IKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAV 651
+ E E+S+ ++ + K+++ER+L ++M++ R LQT++
Sbjct: 1542 SALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSL 1601
Query: 652 VVANDIKCEAQQELRTVKRKL 672
D + ++ E VK+K+
Sbjct: 1602 ----DAETRSRNEALRVKKKM 1618
Score = 72.0 bits (175), Expect = 2e-12
Identities = 122/636 (19%), Positives = 260/636 (40%), Gaps = 87/636 (13%)
Query: 81 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 140
EK AL+ ++ L + +A++ ++N L K +++ D L +++ D
Sbjct: 995 EKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQ-------VDDLEGSLEQEKKVRMD 1047
Query: 141 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQ 200
E R LE K Q+ + DLE + + L E+L + N+ A I
Sbjct: 1048 LERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNAR-----------IED 1096
Query: 201 ESSFGSPTGN---QMSSDIDEYKKNIHGNALRTSGSS----SSDVTK------------- 240
E + GS ++ + I+E ++ + A RT+ + SD+++
Sbjct: 1097 EQALGSQLQKKLKELQARIEELEEELE--AERTARAKVEKLRSDLSRELEEISERLEEAG 1154
Query: 241 --ASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQK 298
S+ + + + R L + +++ + +SV+EL + +Q+
Sbjct: 1155 GATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELG--EQIDNLQR 1212
Query: 299 MEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQE 358
+++ E + L +++ + + + A EK+ LE ++HR +AE+ +
Sbjct: 1213 VKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMC---RTLEDQMNEHRSKAEETQRS 1269
Query: 359 NEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVE 418
+ +L +R K + + + ++ ++ L +G+ L QQL R++E
Sbjct: 1270 ---VNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGK------LTYTQQLEDLKRQLE 1320
Query: 419 EENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQ 478
EE +K +N L L+ RH+ +++ + EE L+ S +
Sbjct: 1321 EE----------VKAKNA-LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1369
Query: 479 GEKQKATEASAVEQTAESCEVQEML--KVARAEK--DLLELSCNELRQELLKANGEIKHV 534
+ K E A+++T E E ++ L ++ AE+ + + C+ L + + EI+
Sbjct: 1370 QWRTKY-ETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIE-- 1426
Query: 535 SSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQH 594
L+ VE+ + + D + + + ++K ES +E++ ++ L ++ +
Sbjct: 1427 -DLMVDVERSNAAAAAL-DKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1484
Query: 595 RAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVA 654
+ + + + + L+E+ SDL QL + K + E + ++ +A+
Sbjct: 1485 KNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAE-------- 1536
Query: 655 NDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 690
K E Q L + L EE K R Q E ++
Sbjct: 1537 ---KMELQSALEEAEASLEHEEGKILRAQLEFNQIK 1569
Score = 65.5 bits (158), Expect = 2e-10
Identities = 132/641 (20%), Positives = 266/641 (41%), Gaps = 98/641 (15%)
Query: 85 LESQVRELLAEAKAKDSEINRLRSEL-------KKYKEKRTLNAEGTDALGPNVDGTSV- 136
LE R+L E KAK++ + L+S ++Y+E+ AE L +
Sbjct: 1312 LEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQW 1371
Query: 137 -SPGDTEPMIRA--LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN------SEGAAS 187
+ +T+ + R LEE K + L + EE + K LE + + +
Sbjct: 1372 RTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVD 1431
Query: 188 HTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDA 247
++ ++ ++ + +E + + + + + S S+++ K + +
Sbjct: 1432 VERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ-KEARSLSTELFKLKNAYEE 1490
Query: 248 SDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTA 307
S EH+ ET R + S GSS ++ EL + +KME S
Sbjct: 1491 S-LEHL--ETFKRENKNLQEEI-SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQ--SAL 1544
Query: 308 EELQATLQ----ELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLM 363
EE +A+L+ ++ Q ++ AE E+ + EK E EQ + + +++
Sbjct: 1545 EEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD----------EEMEQAKRNHLRVV 1594
Query: 364 NLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFE---REKLLNIQQQLTCSLRKVEEE 420
+ LQ + E T + + +++K G L + + ++ Q+ SL+ + ++
Sbjct: 1595 DSLQTSLDAE--TRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKD 1652
Query: 421 NQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGE 480
Q L+ R N+ L E + + NN++ LEE R +E Q E
Sbjct: 1653 TQIQLDDAVRA---NDDLKENIAIVERRNNLLQAELEELRAVVE-------------QTE 1696
Query: 481 KQKATEASAVEQTAESCEVQEMLKVARA-EKDLLELSCNELRQELLKANGEIKHVSSLLA 539
+ + + +T+E ++ + +K ++ ++L+ E+ +A E ++
Sbjct: 1697 RSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAK 1756
Query: 540 KVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKL 599
K D + + AE+L K Q+ ++ + K+M++TI +L+ ++++ + L
Sbjct: 1757 KAITDAAMM-------AEELK----KEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAL 1805
Query: 600 H-NNQLISELESSVIKLE-----EQKSDL---------ERQLKTLTKQMKEETEEWRRFQ 644
+ + +LE+ V +LE EQK + ER++K LT Q +E+ + R Q
Sbjct: 1806 KGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQ 1865
Query: 645 ADLQTAVVVANDIKCEAQQELRTVKRKLLE-EEEKNARLQK 684
D+ + Q +++ KR+ E EE+ N L K
Sbjct: 1866 -----------DLVDKLQLKVKAYKRQAEEAEEQANTNLSK 1895
Score = 62.0 bits (149), Expect = 2e-09
Identities = 78/367 (21%), Positives = 162/367 (44%), Gaps = 44/367 (11%)
Query: 356 SQENEKLMNLLQERVKN--EEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCS 413
S E EK M ++E E E + ELE+K +L++ + ++ Q L +
Sbjct: 842 SAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADA 901
Query: 414 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 473
+ ++ + +++ ++KE NE+L + E+ K +EC LK + L
Sbjct: 902 EERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDEC----SELKRDIDDL 957
Query: 474 KSHL-QGEKQK-ATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEI 531
+ L + EK+K ATE T E + E++ EK L+ + + +L ++
Sbjct: 958 ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 1017
Query: 532 KHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELED-- 589
++ K+E+ L + EQ + + L+ + + ++K +E+I +LE+
Sbjct: 1018 NTLTKAKVKLEQQVDDL----EGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1073
Query: 590 -------------------QVEQHRAVKLHNNQLISELESSVIKLEEQ-------KSDLE 623
++E +A+ + + EL++ + +LEE+ ++ +E
Sbjct: 1074 QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVE 1133
Query: 624 RQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEA--QQELRTVKRKLLEEEEKNAR 681
+ L+++++E +E R +A T+V + + K EA Q+ R ++ L+ E A
Sbjct: 1134 KLRSDLSRELEEISE--RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAA 1191
Query: 682 LQKELGD 688
L+K+ D
Sbjct: 1192 LRKKHAD 1198
Score = 60.1 bits (144), Expect = 7e-09
Identities = 71/288 (24%), Positives = 122/288 (42%), Gaps = 46/288 (15%)
Query: 414 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 473
L+ E E + A +KEE +L E LE + K LEE V+L E L
Sbjct: 840 LKSAEREKEMA-----SMKEEFTRLKEALE----KSEARRKELEEKMVSL---LQEKNDL 887
Query: 474 KSHLQGEKQKATEA---------------SAVEQTAESCEVQEMLKVA-RAEKDLLELSC 517
+ +Q E+ +A + V++ E E +E + A+K LE C
Sbjct: 888 QLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDEC 947
Query: 518 NELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEI 577
+EL+++ I + LAKVEK+ K +++ + L+ L E ++ E
Sbjct: 948 SELKRD-------IDDLELTLAKVEKE----KHATENKVKNLTEEMAGLDEIIAKLTKEK 996
Query: 578 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 637
K ++E + D ++ ++ L + +KLE+Q DLE L+ K +
Sbjct: 997 KALQEAHQQALDDLQAEE-------DKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLE 1049
Query: 638 EEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKE 685
R+ + DL+ D++ + QQ +K+K E NAR++ E
Sbjct: 1050 RAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDE 1097
Score = 57.8 bits (138), Expect = 3e-08
Identities = 116/615 (18%), Positives = 234/615 (38%), Gaps = 63/615 (10%)
Query: 48 RKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEA-KAKDSEINRL 106
++ +S S TK+ + ++ E +K A Q E EA AK S + +
Sbjct: 1358 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKT 1417
Query: 107 RSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEEN 166
+ L+ E ++ E ++A +D + + ++ ++K + Q EL ++E
Sbjct: 1418 KHRLQNEIEDLMVDVERSNAAAAALDKKQ---RNFDKILAEWKQKYEESQSELESSQKEA 1474
Query: 167 RVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGN 226
R L +L L+++ E + H QE SD+ E
Sbjct: 1475 RSLSTELFKLKNA--YEESLEHLETFKRENKNLQEEI----------SDLTEQ------- 1515
Query: 227 ALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSE 286
L +SG + ++ K +A E + + S K + + + E
Sbjct: 1516 -LGSSGKTIHELEKVRKQLEAEKME-LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE 1573
Query: 287 LSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFH 346
LA E++++ + NH + LQ +L + + E +K+ + +E
Sbjct: 1574 RKLAEKDEEMEQAKRNHLRVVDSLQTSLDA---ETRSRNEALRVKKKMEGDLNEMEIQLS 1630
Query: 347 QHRERAEQLSQENEKLMNLLQE-RVKNEEPTTQEGKI---IELEQKCTGILEQGRFEREK 402
A + ++ + L +LL++ +++ ++ + I + ++ +L+ E E+
Sbjct: 1631 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA---ELEE 1687
Query: 403 LLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKL------------------NEFLEL 444
L + +Q S + E+E E ++ L +N L E ++
Sbjct: 1688 LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1747
Query: 445 ERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLK 504
R+ K + + + E LK E + +HL E+ K ++ + E +
Sbjct: 1748 CRNAEEKAKKAITDAAMMAEELKKEQDT-SAHL--ERMKKNMEQTIKDLQHRLDEAEQIA 1804
Query: 505 VARAEKDL--LELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRT 562
+ +K L LE EL EL E K + + + K +KE+ +Q E+ +
Sbjct: 1805 LKGGKKQLQKLEARVRELENEL---EAEQKRNAESVKGMRKSERRIKELT-YQTEEDRKN 1860
Query: 563 SLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDL 622
L+LQ+ + ++K K E E+Q + + + E E E Q + L
Sbjct: 1861 LLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1920
Query: 623 ERQLKTL-TKQMKEE 636
+ + + TK + EE
Sbjct: 1921 RAKSRDIGTKGLNEE 1935
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 90.9 bits (224), Expect = 4e-18
Identities = 139/614 (22%), Positives = 238/614 (38%), Gaps = 97/614 (15%)
Query: 140 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN-------SEGAASHTGDS 192
+TE + ++E+ + + EL+ E + + L+EKL+ L N +E +
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE 904
Query: 193 SCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEH 252
C I + + DE + NA T+ + + L D D E
Sbjct: 905 RCDQLIKAKFQLEAKIKEVTERAEDEEEI----NAELTAKKRKLEDECSELKKDIDDLEL 960
Query: 253 ITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQA 312
A+ + K +T N ELS L E I K+ + E Q
Sbjct: 961 TLAKV------------EKEKHATENKVKNLTEELS--GLDETIAKLTREKKALQEAHQQ 1006
Query: 313 TLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKN 372
L +L ++ V L KL + LE+S Q ++ L + KL
Sbjct: 1007 ALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKL---------- 1056
Query: 373 EEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLR-KVEEENQGALEMIKRL 431
EG ++L Q+ LE + + ++ L + C L+ KVE+E L+ K++
Sbjct: 1057 ------EGD-LKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKI 1109
Query: 432 KE---ENEKLNEFLELER-------HNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEK 481
KE E+L E +E ER + A+ LEE E L+ G + ++ K
Sbjct: 1110 KELQARIEELEEEIEAERATRAKTEKQRSDYARELEELS---ERLEEAGGVTSTQIELNK 1166
Query: 482 QKATEASAVEQTAESCEVQEMLKVARAEK-------------DLLELSCNELRQELLKAN 528
++ E + + E +Q VA K D L+ +L +E +
Sbjct: 1167 KREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1226
Query: 529 GEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLK---LQEKASESDAEIKDMKETIF 585
EI +SS + V K + L++IC +QLS K +Q SE + ++
Sbjct: 1227 LEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAG 1286
Query: 586 ELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ------------- 632
EL Q+E+ ++ +S+L S +Q +L+RQL+ K
Sbjct: 1287 ELSRQLEEKESI-------VSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRH 1339
Query: 633 ----MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEE-EEKNARLQKELG 687
++E+ EE + +A+LQ A+ AN + + + T + EE EE +L + L
Sbjct: 1340 DCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1399
Query: 688 DVQGHGRVVTSRAA 701
D + V ++ A
Sbjct: 1400 DSEEQVEAVNAKCA 1413
Score = 76.3 bits (186), Expect = 9e-14
Identities = 130/649 (20%), Positives = 254/649 (39%), Gaps = 86/649 (13%)
Query: 81 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 140
EK A E++V+ L E D I +L E K +E + A V+ + +
Sbjct: 968 EKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSK 1027
Query: 141 TEPMIRALEEKNKNFQKELSDLEEENRVLK-------EKLIYLEHSPNSEGAASHTGD-- 191
E + LE + +K DLE R L+ E ++ LE+ D
Sbjct: 1028 LEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFE 1087
Query: 192 -SSCPTSITQESSFG---SPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDA 247
+ + E + G ++ + I+E ++ I T+A
Sbjct: 1088 YCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAER----------ATRAKTEKQR 1137
Query: 248 SDFEHITAETPSR-----PLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEEN 302
SD+ E R ++ST + + + E +L + + +
Sbjct: 1138 SDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQH-EAMVAALRKK 1196
Query: 303 HHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL 362
H + EL + L +Q +++ +E + +D+ + S + + E++ + E
Sbjct: 1197 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLED- 1255
Query: 363 MNLLQERVKNEEP-------TTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLR 415
L + R KNEE TTQ+ ++ Q G L + E+E +++ QL+ S +
Sbjct: 1256 -QLSEARGKNEEIQRSLSELTTQKSRL----QTEAGELSRQLEEKESIVS---QLSRSKQ 1307
Query: 416 KVEEENQGALEMIKRLKEENEKLNEF---LELERHNNNMMAKTLEECRVTLEGLKMENGS 472
++ + E+ ++L+EEN+ N L+ RH+ +++ + EE + L+
Sbjct: 1308 AFTQQTE---ELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1364
Query: 473 LKSHLQGEKQKATEASAVEQTAESCEVQ----EMLKVARAEKDLLELSCNELRQELLKAN 528
S + + K E A+++T E E + + L+ + + + + C L + +
Sbjct: 1365 ANSEVAQWRTKY-ETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQ 1423
Query: 529 GEIKHVSSLLAKVEKDYSYLKEICDHQA---EQLSRTSLKLQEKASESDAEIKDMKETIF 585
GE++ L+ VE+ S + Q + L+ K +E +E +A +K+ +
Sbjct: 1424 GEVE---DLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLST 1480
Query: 586 EL-------EDQVEQHRAVKLHNNQL-----------------ISELESSVIKLEEQKSD 621
EL E+ ++Q VK N L I ELE S ++E +K+D
Sbjct: 1481 ELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKAD 1540
Query: 622 LERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKR 670
++ L+ ++ E + R Q +L + E +E+ +KR
Sbjct: 1541 IQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKR 1589
Score = 66.6 bits (161), Expect = 7e-11
Identities = 161/731 (22%), Positives = 280/731 (38%), Gaps = 155/731 (21%)
Query: 76 ENEGGEKAALESQVREL---LAEAKAKDSEINRLRSELKKYKEKRTLNA--------EGT 124
E+ KA LE R L L+EA+ K+ EI R SEL K + A E
Sbjct: 1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKE 1296
Query: 125 DALGPNVDGTSVSPGDTEPMIRALEEKNKN-------FQKELSDLE------EENRVLKE 171
+ TE + R LEE+NK Q D + EE + K
Sbjct: 1297 SIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKA 1356
Query: 172 KLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTS 231
+L NSE A T + T+E Q D +E + ++
Sbjct: 1357 ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKC---- 1412
Query: 232 GSSSSDVTKASLSPDASDF--EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSL 289
+S + TK L + D + A + + L F S +EL
Sbjct: 1413 --ASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEA 1470
Query: 290 A-----SLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELT---AENEKLVDEKTIL 341
+ SL+ ++ K++ + ++L+ +E + +Q + +LT AEN K +
Sbjct: 1471 SLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTI------ 1524
Query: 342 ETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQ-GRFER 400
H+ + +Q+ E + L+E E +E KI+ ++ + T + + R
Sbjct: 1525 ----HELEKSRKQIELEKADIQLALEEAEAALEH--EEAKILRIQLELTQVKSEIDRKIA 1578
Query: 401 EKLLNIQQQLTCSLRKVEEENQGAL--------EMIKRLKEENEKLNEFLELERHNNNMM 452
EK I+Q L + ++ E Q AL E I+ K+ LNE H N
Sbjct: 1579 EKDEEIEQ-LKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQA 1637
Query: 453 AKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAE--SCEVQEMLKVARAEK 510
A+TL+ R LK L L+G++ + + VE+ A EV+E+ RA
Sbjct: 1638 AETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEEL----RATL 1693
Query: 511 DLLELSCNELRQELLKANGEIKHV----SSLL---AKVEKDYSYLKEICDHQAEQLSRTS 563
+ E + QELL +N ++ + +SL+ K+E D L+ + E SR +
Sbjct: 1694 EQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQS----EVEDASRDA 1749
Query: 564 LKLQEKASES--DAEI-------------------KDMKETIFELEDQVEQHRAVKLHNN 602
+EKA ++ DA + K++++T+ +L+ ++++ + L
Sbjct: 1750 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG 1809
Query: 603 QL-ISELESSVIKLE-----EQKSDLE---------RQLKTLTKQMKEETE--------- 638
+ I +LE+ + +LE EQK + E R++K LT Q +E+ +
Sbjct: 1810 KKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLV 1869
Query: 639 --------------------------EWRRFQADLQTA-----VVVANDIKCEAQQELRT 667
++R+ Q +L+ A + + K A+ T
Sbjct: 1870 DKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFT 1929
Query: 668 VKRKLLEEEEK 678
R ++ E E+
Sbjct: 1930 SSRMVVHESEE 1940
Score = 54.3 bits (129), Expect = 4e-07
Identities = 67/288 (23%), Positives = 121/288 (42%), Gaps = 46/288 (15%)
Query: 414 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 473
L+ E E + A +KEE +K + E + K LEE VTL E L
Sbjct: 841 LKSAETEKEMAT-----MKEEFQKTKD----ELAKSEAKRKELEEKLVTLV---QEKNDL 888
Query: 474 KSHLQGEKQKATEA---------------SAVEQTAESCEVQEMLKVA-RAEKDLLELSC 517
+ +Q E + +A + +++ E E +E + A+K LE C
Sbjct: 889 QLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 948
Query: 518 NELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEI 577
+EL+++ I + LAKVEK+ K +++ + L+ L E ++ E
Sbjct: 949 SELKKD-------IDDLELTLAKVEKE----KHATENKVKNLTEELSGLDETIAKLTREK 997
Query: 578 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 637
K ++E + D ++ ++ L + KLE+Q DLE L+ K +
Sbjct: 998 KALQEAHQQALDDLQAEE-------DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLE 1050
Query: 638 EEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKE 685
R+ + DL+ A D++ + QQ +K+K E + ++++ E
Sbjct: 1051 RNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDE 1098
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 90.1 bits (222), Expect = 6e-18
Identities = 97/418 (23%), Positives = 192/418 (45%), Gaps = 29/418 (6%)
Query: 286 ELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSF 345
E L + K Q++ E + AE+LQA + ++ ++M L A+ ++L + LE+
Sbjct: 872 EGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRV 931
Query: 346 HQHRERAEQLSQENEKL---MNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREK 402
+ ER + L E +K+ + L+E++ EE Q+ ++LE K T + + E E
Sbjct: 932 EEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQK---LQLE-KVTAEAKIKKMEEEI 987
Query: 403 LLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVT 462
LL ++ Q + +++ + E +L EE EK ++ R+ +M LEE
Sbjct: 988 LL-LEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKI-RNKQEVMISDLEERLKK 1045
Query: 463 LEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQ 522
E + E K L GE +Q AE + LK+ A+K+ EL+
Sbjct: 1046 EEKTRQELEKAKRKLDGE-----TTDLQDQIAELQAQIDELKLQLAKKE------EELQG 1094
Query: 523 ELLKANGEIKHVSSLLAKVEKDYSYLKEIC-DHQAEQLSRTSLKLQEKASESDAEIKDMK 581
L + + E H ++ L V + + + E+ D ++E+ SR K +++ + E++ +K
Sbjct: 1095 ALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRN--KAEKQKRDLSEELEALK 1152
Query: 582 ETIFELEDQVEQHRAVKLHNNQLISE----LESSVIKLEEQKSDLERQLKTLTKQMKEET 637
+ + D + ++ Q ++E LE E Q D+ ++ T +++ E+
Sbjct: 1153 TELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQL 1212
Query: 638 EEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRV 695
E+ +RF+A+L+ E E++ +++ E E K +L ++ ++ H +V
Sbjct: 1213 EQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL--HAKV 1268
Score = 88.2 bits (217), Expect = 2e-17
Identities = 149/677 (22%), Positives = 281/677 (41%), Gaps = 104/677 (15%)
Query: 81 EKAALESQVRELLAEAKAK--DSEINRLRSELKKY-KEKRTLN---AEGTDALGPNVD-- 132
E A + Q+ ++ AEAK K + EI L + K+ KEK+ + AE + L +
Sbjct: 963 EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA 1022
Query: 133 -GTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGD 191
+ E MI LEE+ K +K +LE+ R L + L+ + A
Sbjct: 1023 KNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ----DQIAELQAQI 1078
Query: 192 SSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFE 251
+ ++ G D + KN NAL+ + + + ++
Sbjct: 1079 DELKLQLAKKEE--ELQGALARGDDETLHKN---NALKVVRELQAQIAELQEDFESEKAS 1133
Query: 252 HITAETPSRPLSSTSNPFKSSKCSTAGSSP-----NSVSELSLASLTEKIQKMEENHHST 306
AE R LS K+ T ++ + E +A L + +++ +NH +
Sbjct: 1134 RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQ 1193
Query: 307 AEELQ----ATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERA------EQLS 356
++++ L+ELS+Q + + A EK K LET ++E A +Q+
Sbjct: 1194 IQDMRQRHATALEELSEQLEQAKRFKANLEK---NKQGLETD---NKELACEVKVLQQVK 1247
Query: 357 QENEKLMNLLQERVKNEEPTTQEGKIIELE------------QKCTGILEQGRFEREKLL 404
E+E L +V+ EG + +E + +LE+ + K
Sbjct: 1248 AESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFA 1307
Query: 405 ----NIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECR 460
+++ QL + ++EE + L + R+++ E+ N E + EE R
Sbjct: 1308 KDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE--------EEAR 1359
Query: 461 VTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARA------EK---- 510
LE + +L+S L K+K + ++ E + +++LK A A EK
Sbjct: 1360 KNLEKQVL---ALQSQLADTKKKVDDDLGTIESLEEAK-KKLLKDAEALSQRLEEKALAY 1415
Query: 511 DLLELSCNELRQELLKANGEIKH---VSSLLAKVEKDYSYL----KEICDHQAEQLSRTS 563
D LE + N L+QEL ++ H V+S L K +K + L K I AE+ R
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475
Query: 564 LKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLIS----------ELESSVI 613
+ +EK +++ + + ++E + E+ Q++ ++ L+S ELE S
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535
Query: 614 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL 673
LE+Q ++ QL+ L +++ + R + ++Q +K + +++L+T
Sbjct: 1536 ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQA-------MKAQFERDLQTRDE--- 1585
Query: 674 EEEEKNARLQKELGDVQ 690
+ EEK L K++ +++
Sbjct: 1586 QNEEKKRLLIKQVRELE 1602
Score = 80.9 bits (198), Expect = 4e-15
Identities = 137/666 (20%), Positives = 269/666 (40%), Gaps = 76/666 (11%)
Query: 71 TKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPN 130
T+ + E +K L S++R+L E K E E +K EK+ L AL
Sbjct: 1320 TQELLQEETRQKLNLSSRIRQL-EEEKNSLQEQQEEEEEARKNLEKQVL------ALQSQ 1372
Query: 131 VDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTG 190
+ T D I +LEE K K L D E ++ L+EK + + ++
Sbjct: 1373 LADTKKKVDDDLGTIESLEEAKK---KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQEL 1429
Query: 191 DSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDF 250
D Q Q++S++++ +K + L S S A + +
Sbjct: 1430 DDLTVDLDHQR---------QVASNLEKKQKKF--DQLLAEEKSIS----ARYAEERDRA 1474
Query: 251 EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEEL 310
E E ++ LS ++ + N + L + +N H +
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSK 1534
Query: 311 QATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ----LSQENEKLMNLL 366
+A Q++ + + ++EL E + D K LE + + + E+ ++NE+ LL
Sbjct: 1535 RALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL 1594
Query: 367 QERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALE 426
++V+ E ++ E +Q+ + + + E + L +++ Q +E N+ E
Sbjct: 1595 IKQVRELEAELED----ERKQRALAVASKKKMEID-LKDLEAQ-------IEAANKARDE 1642
Query: 427 MIKRLKEENEKLNEF---LELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQK 483
+IK+L++ ++ ++ LE R + + + +E L+ L+ E L+ L ++
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEEL-ASSER 1701
Query: 484 ATEASAVEQTAESCEVQEMLKVARA---EKDLLELSCNELRQELLKANGEIK-------- 532
A + E+ + E+ A EK LE +L +EL + ++
Sbjct: 1702 ARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRK 1761
Query: 533 ---HVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKD--------MK 581
V +L A++ + S ++ D+ +QL R + +L+ K E + +K ++
Sbjct: 1762 TTLQVDTLNAELAAERSAAQK-SDNARQQLERQNKELKAKLQELEGAVKSKFKATISALE 1820
Query: 582 ETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWR 641
I +LE+Q+EQ + N+L+ E + ++ Q D R +QM++ +
Sbjct: 1821 AKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMK 1880
Query: 642 RFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAA 701
+ + L+ A A A R ++R+L + E N L +E+ ++ R R
Sbjct: 1881 QLKRQLEEAEEEAT----RANASRRKLQRELDDATEANEGLSREVSTLKNRLR----RGG 1932
Query: 702 PPSLGS 707
P S S
Sbjct: 1933 PISFSS 1938
Score = 50.4 bits (119), Expect = 6e-06
Identities = 70/305 (22%), Positives = 130/305 (42%), Gaps = 43/305 (14%)
Query: 385 LEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLN-EFLE 443
L++ C L+ ++ ++ + L R+ EEE Q E + ++KE+ K+ E E
Sbjct: 819 LQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQ-EEELQAKDEELLKVKEKQTKVEGELEE 877
Query: 444 LERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEML 503
+ER + ++ E L LQ E + EA +EM
Sbjct: 878 MERKHQQLLE---------------EKNILAEQLQAETELFAEA------------EEMR 910
Query: 504 KVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTS 563
A+K LE ++L + + + + + K++ L+E D E+ +R
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE--EEGARQK 968
Query: 564 LKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDL- 622
L+L++ +E A+IK M+E I LEDQ + K I+E S + + EE+ +L
Sbjct: 969 LQLEKVTAE--AKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 1026
Query: 623 ------ERQLKTLTKQMKEE---TEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL 673
E + L +++K+E +E + + L D E Q ++ +K +L
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA 1086
Query: 674 EEEEK 678
++EE+
Sbjct: 1087 KKEEE 1091
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 90.1 bits (222), Expect = 6e-18
Identities = 170/739 (23%), Positives = 319/739 (43%), Gaps = 106/739 (14%)
Query: 29 EFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQ 88
E V +++ER + +P + S ++ +TP+PT L S++ KQ + E A +++
Sbjct: 208 ELIVDLTQERDYLQA-QHPPSPIKSSSADSTPSPTSSL---SSEDKQ-HLAVELADTKAR 262
Query: 89 VRELLAEAKAKDS-------EINRLRSELKKYKEKR---TLNAEGTDALGPNVDGTSVSP 138
+R + E + K E+++L EL+K K++ +A A +D
Sbjct: 263 LRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKA 322
Query: 139 GDTEPM---IRALEEKNKN---FQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDS 192
E + + +EK + ++ + +L E+N +L E LE AA GD
Sbjct: 323 NRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLT---AARARGDK 379
Query: 193 SCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS---D 249
+ +E+ + + D D KK I L K S++ A +
Sbjct: 380 --VHELEKENLQLKSKLHDLELDRDTDKKRI--EELLEENMVLEIAQKQSMNESAHLGWE 435
Query: 250 FEHITAETPSRPLSSTSNPFKSSKCSTA---------GSSPNSVSELSLASLT-----EK 295
E ++ S S F+ ++C+++ S +++ L ASL K
Sbjct: 436 LEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLK 495
Query: 296 IQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHR-ERAEQ 354
++E+ +H +++++ +L ++Q Q+L +E+L+ EK L++ + ++A Q
Sbjct: 496 CGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQ 555
Query: 355 ---LSQENEKLMNLLQE-RVKNEEPTTQEGKIIELEQK--------CTGILEQGRFEREK 402
L QE + L + R +++ + K +E E K G L Q FE+
Sbjct: 556 IKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEK-- 613
Query: 403 LLNIQQQLTCSLRKVEEENQGALEM---IKRLKEENEKL-NEFLELERHNNNMMAKTLEE 458
+QL L + +E+ + A ++ ++RL+EEN +L + LE + A E
Sbjct: 614 -----RQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHES 668
Query: 459 CRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQ-----TAESCEVQEMLKVARAEKDLL 513
+GL++EN +L+ L + + + +E+ AE+ E++ +++ R L
Sbjct: 669 -----QGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKL 723
Query: 514 ELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASES 573
E Q+L + E++ LL + K E + + +S +L+LQ+ S
Sbjct: 724 AQMERE-NQQLEREKEELRKNVDLLKALGKK----SERLELSYQSVSAENLRLQQSLESS 778
Query: 574 DAEIKDMKETIFELEDQVEQHR----AVKLHNNQL------ISELESSVIKLEEQKSDLE 623
+ + ++ + ELE + + R A++L N QL LE V +LE+ K LE
Sbjct: 779 SHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLE 838
Query: 624 RQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEA-QQEL---RTVKRKLLEEEEKN 679
++ K L +Q+ E + D TA + A + + A +EL R KL E E+ N
Sbjct: 839 KEAKRLWQQV-----ELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDN 893
Query: 680 ARLQKELGDVQGHGRVVTS 698
L K+ V H R +T+
Sbjct: 894 RDLTKQ---VTVHARTLTT 909
Score = 65.1 bits (157), Expect = 2e-10
Identities = 107/460 (23%), Positives = 182/460 (39%), Gaps = 82/460 (17%)
Query: 304 HSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFH-----QHRERAEQLSQE 358
H E+ + + ++ +Q L EN +L + T LET+ +H + QL
Sbjct: 617 HRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENR 676
Query: 359 N-EKLMNLLQERVKNEEPTTQEGKIIELEQ-KCTGILEQGRFEREKLLNIQQQLTCSLRK 416
K ++ LQ E ++ K ++ E + ++E RF KL ++++ L +
Sbjct: 677 TLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERE-NQQLER 735
Query: 417 VEEENQGALEMIKRLKE--------------ENEKLNEFLELERHNNNMMAKTLEEC--- 459
+EE + ++++K L + EN +L + LE H + L E
Sbjct: 736 EKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAE 795
Query: 460 ----RVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEV-------QEMLKVARA 508
R LE L++ N L+ + K E + +E+ + E Q LK A
Sbjct: 796 RQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVL 855
Query: 509 EKDLLELSCNELRQELL-KANGEIKHVSSLLAKVEKDYSYL-KEICDHQA------EQLS 560
+ +LS E L K + + L ++EKD L K++ H E L
Sbjct: 856 DDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLV 915
Query: 561 RTSLKLQEKASESDAEIKDMKET-----IFELEDQVEQHRAVKLHNNQLISEL------- 608
LK Q+ +SE D +++++ + ED K+ + S L
Sbjct: 916 LEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMK 975
Query: 609 ESSVIKLE---EQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIK------- 658
E ++ LE E+K+ L RQL++ + +K+E E R+ Q + Q + N K
Sbjct: 976 EEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQH---LQNSFKHPAGKTA 1032
Query: 659 -------------CEAQQELRTVKRKLLEEEEKNARLQKE 685
EA EL VK + +E E NA LQ E
Sbjct: 1033 ASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAE 1072
Score = 47.4 bits (111), Expect = 5e-05
Identities = 122/623 (19%), Positives = 238/623 (38%), Gaps = 108/623 (17%)
Query: 81 EKAALESQVREL-LAEAKAKDSEINR--LRSELKKYKEKRTLNAEGTDALGPNVDGTSVS 137
E+ AL + L LA A+ + +E +R L E+ + ++ + L + L V+
Sbjct: 795 ERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAV 854
Query: 138 PGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTS 197
D+ + A+E++++ KEL+ + LKE N + T + T+
Sbjct: 855 LDDSTAKLSAVEKESRALDKELARCRDAAGKLKEL-----EKDNRDLTKQVTVHARTLTT 909
Query: 198 ITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAET 257
+ ++ Q+SS++D+ S ++ K L+ +
Sbjct: 910 LREDLVLEKLKSQQLSSELDKL---------------SQELEKVGLNREL---------- 944
Query: 258 PSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME---ENHHSTAEELQATL 314
L + +K S + +LA EKI +E E S +L++ L
Sbjct: 945 ----LLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESEL 1000
Query: 315 QELSDQQQMVQELTAENEKLVDE-KTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE 373
Q L + + +++ E + L + K + H+ + E M LL RVK+
Sbjct: 1001 QMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELL--RVKD- 1057
Query: 374 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQ-QQLTCSLRKVEEENQGALEMIKRLK 432
+ IELE+ + + + +E+L +++ Q +T S + + + Q A
Sbjct: 1058 -------RAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAF------- 1103
Query: 433 EENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQ 492
L+ HN + +T + L++EN +L S +
Sbjct: 1104 -----------LQEHNTTLQTQTAK--------LQVENSTLSS------------QSAAL 1132
Query: 493 TAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEIC 552
TA+ +Q E + L+ +L + +H+ +L + +Y L I
Sbjct: 1133 TAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEAL--IR 1190
Query: 553 DHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSV 612
H + +L+L+ K E DM + ELE E+ + + L E ++
Sbjct: 1191 QHSCLKTLHRNLELEHK--ELGERHGDMLKRKAELE---EREKVLTTEREALQQEQRTNA 1245
Query: 613 IKLEEQ---KSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVK 669
+ + E + +L+R + L Q+K E EE +L+T++ AQ EL +
Sbjct: 1246 LAMGENQRLRGELDR-VNFLHHQLKGEYEELHAHTKELKTSL-------NNAQLELNRWQ 1297
Query: 670 RKLLEEEEKNARLQKELGDVQGH 692
+ E +E++ + L + H
Sbjct: 1298 ARFDELKEQHQTMDISLTKLDNH 1320
Score = 33.5 bits (75), Expect = 0.70
Identities = 23/76 (30%), Positives = 37/76 (48%), Gaps = 11/76 (14%)
Query: 300 EENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQEN 359
EENHH L + +Q LS Q QM+ E EN++ E+ Q+ ++ L +
Sbjct: 1333 EENHH-----LLSQIQLLSQQNQMLLEQNMENKEQYHEEQ------KQYIDKLNALRRHK 1381
Query: 360 EKLMNLLQERVKNEEP 375
EKL + ++ K +P
Sbjct: 1382 EKLEEKIMDQYKFYDP 1397
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 88.2 bits (217), Expect = 2e-17
Identities = 108/488 (22%), Positives = 217/488 (44%), Gaps = 93/488 (19%)
Query: 292 LTEKIQKMEEN---HHSTAEELQ-------ATLQELSDQQQMVQELTAENEKLVDEKTIL 341
+ + IQ++EE S ++LQ A L++L ++Q ++++ +N KL EK +L
Sbjct: 941 MQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILED---QNCKLAKEKKLL 997
Query: 342 E-------TSFHQHRERAEQLSQ---ENEKLMNLLQERVKNEEPTTQ---------EGKI 382
E T+ + E+++ L++ ++E ++ L+ER++ EE Q EG
Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057
Query: 383 IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEE---NQGALEMIKRLKEENEKLN 439
+L + + Q + +L +++L +L +VEEE AL+ I+ L+ + +L
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ 1117
Query: 440 EFLELERHNNNMMAKTLEECRVTLEGLKME-----------------------------N 470
E LE ER + N K + LE LK E
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLE 1177
Query: 471 GSLKSH-LQGEKQKATEASAVEQTAESCEVQEMLKV-ARAEKDLLELSCNELRQE---LL 525
K+H Q ++ + + AVE+ AE E + +K K LE EL E LL
Sbjct: 1178 EEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL 1237
Query: 526 KANGEIKH----VSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKA---SESDAEIK 578
+ G+ +H V + L +++ ++ + + A+++++ ++L S+SD++
Sbjct: 1238 QGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSS 1297
Query: 579 DMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLK-------TLTK 631
+ + LE Q++ + + N+ L + + ++E++K+ QL+ L K
Sbjct: 1298 KLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357
Query: 632 Q---MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEE-------EEKNAR 681
Q + + + ++ D + A ++K + Q++L + ++ E+ E+ R
Sbjct: 1358 QIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTR 1417
Query: 682 LQKELGDV 689
LQ+EL D+
Sbjct: 1418 LQQELDDL 1425
Score = 88.2 bits (217), Expect = 2e-17
Identities = 137/702 (19%), Positives = 294/702 (41%), Gaps = 83/702 (11%)
Query: 63 TKHLRTPSTKPKQ--ENEGGEKAALESQVRELL-----AEAKAK--DSEINRLRSELKKY 113
TK ++ K KQ ENE GE L ++V+ LL +E K K ++++ L+ + +
Sbjct: 1208 TKRVKANLEKAKQTLENERGE---LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEG 1264
Query: 114 KEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSD----LEEENRV- 168
+ RT A+ L +D + ++ L + + +L D L+EENR
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324
Query: 169 --LKEKLIYLEHSPNS-------EGAASHTGDSSCPTSITQESSFGSPTGNQMS--SDID 217
L KL +E NS E A H + T Q + + + +
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE 1384
Query: 218 EYK----KNIHGNALR----TSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPF 269
E K K++ G + R + + TK L + D + + + S+ +
Sbjct: 1385 EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD---LLVDLDHQRQSACNLEK 1441
Query: 270 KSSKCSTAGSSPNSVSELSLASLTE---KIQKMEENHHSTAEELQATLQELSDQQQMVQE 326
K K + ++S + ++ E S A L+ +++ ++ +++ ++
Sbjct: 1442 KQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQ 1501
Query: 327 LTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKI---- 382
E E L+ K + S H+ + L Q+ E++ L+E +++E T++ K+
Sbjct: 1502 FRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEE-LEDELQATEDAKLRLEV 1560
Query: 383 ------IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENE 436
+ E+ G EQ ++++L+ +++ L ++ A+ K+L+ + +
Sbjct: 1561 NLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLK 1620
Query: 437 KLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQG--EKQKATEASAVEQTA 494
L ++ N + K L + + ++ E ++ + + K E A
Sbjct: 1621 DLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEA 1680
Query: 495 ESCEVQEMLKVARAEKDLLELSCNELRQELLKANG-------EIKHVSSLLAKVEKDYSY 547
E ++QE L A K + +EL E+ ++G E + + + +A++E++
Sbjct: 1681 EMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEE 1740
Query: 548 LKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLI-- 605
+ + ++L + +L++ + ++ + E ++ + Q++ +K+ ++
Sbjct: 1741 EQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGT 1800
Query: 606 --SELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQ 663
S+ ++S+ LE + + LE QL TK+ + ++ RR + L+ ++ +D + A+Q
Sbjct: 1801 VKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQ 1860
Query: 664 ----------ELRTVKRKLLEEEEKNAR-------LQKELGD 688
L+ +KR+L E EE+ R LQ+EL D
Sbjct: 1861 YKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELED 1902
Score = 86.3 bits (212), Expect = 9e-17
Identities = 97/437 (22%), Positives = 190/437 (43%), Gaps = 70/437 (16%)
Query: 308 EELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQ 367
E+LQA + ++ +++ LTA+ ++L + LE + ER + L E +K+ +Q
Sbjct: 887 EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946
Query: 368 ---ERVKNE---------EPTTQEGKIIELEQKCTGILEQG-RFEREKLLNIQQQLTCSL 414
E+++ E E T E K+ +LE++ + +Q + +EK L + +
Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006
Query: 415 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEG--------- 465
EEE + + + +LK ++E + LE + LE+ R LEG
Sbjct: 1007 NLTEEEEKS--KSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQI 1064
Query: 466 ---------LKMENGSLKSHLQGEKQKATEASAVEQTA---------ESCEVQEMLKVAR 507
LKM+ + LQ + E +A + A + E+QE L+ R
Sbjct: 1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124
Query: 508 AEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQ 567
A ++ E +L +EL E++ A + E+ + ++++ L+
Sbjct: 1125 ASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQ-------ELRSKREQEVNILKKTLE 1177
Query: 568 EKASESDAEIKDMK----ETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLE 623
E+A +A+I++M+ + + EL +Q+EQ + VK + LE + LE ++ +L
Sbjct: 1178 EEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVK-------ANLEKAKQTLENERGELA 1230
Query: 624 RQLKTLTKQMKEETEEWRRFQADLQTAVVVAN----------DIKCEAQQELRTVKRKLL 673
++K L + + + ++ +A LQ V N D + Q EL V L
Sbjct: 1231 NEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLS 1290
Query: 674 EEEEKNARLQKELGDVQ 690
+ + K+++L K+ ++
Sbjct: 1291 QSDSKSSKLTKDFSALE 1307
Score = 80.5 bits (197), Expect = 5e-15
Identities = 146/702 (20%), Positives = 285/702 (40%), Gaps = 108/702 (15%)
Query: 74 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSE---LKKYKEKRTLN---AEGTDAL 127
+++ E E A + Q+ ++ EAK K E ++ E K KEK+ L AE T L
Sbjct: 949 EEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNL 1008
Query: 128 GPNVDGT---SVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKE------------- 171
+ + + E MI LEE+ + +K+ +LE+ R L+
Sbjct: 1009 TEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQ 1068
Query: 172 ------KLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHG 225
K+ + + A + + + ++ + ++ S I E ++++
Sbjct: 1069 AQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKI------RELESQISELQEDLES 1122
Query: 226 NALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVS 285
+ + ++ K L + E + E S+ + SK +
Sbjct: 1123 ER---ASRNKAEKQKRDLG---EELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTL 1176
Query: 286 ELSLASLTEKIQKMEENHHSTAEELQATLQEL----SDQQQMVQELTAENEKLVDEKTIL 341
E + +IQ+M + H EEL L++ ++ ++ Q L E +L +E +L
Sbjct: 1177 EEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVL 1236
Query: 342 ----ETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGR 397
S H+ ++ QL + K ERV+ E +EL+ TG+L Q
Sbjct: 1237 LQGKGDSEHKRKKVEAQLQELQVKFNE--GERVRTELADKVTKLQVELDN-VTGLLSQSD 1293
Query: 398 FEREKLLN----IQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLEL----ERHNN 449
+ KL ++ QL + ++EEN+ L + +LK+ ++ N F E E +
Sbjct: 1294 SKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKH 1353
Query: 450 NM-------------MAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAES 496
N+ M K +E+ LE + L+ L+G Q+ E A E
Sbjct: 1354 NLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413
Query: 497 CEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAK---VEKDYSYLKEICD 553
+ + + E D L + + RQ + K LLA+ + Y+ ++ +
Sbjct: 1414 TKTR-----LQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAE 1468
Query: 554 HQAEQLSRTSLKLQ---EKASESDAEIKDM-KETIFELEDQVEQHRAVKLHNNQLISELE 609
+A + +L L E+A E AE++ + K+ E+ED + V + + ELE
Sbjct: 1469 AEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDV----GKSVHELE 1524
Query: 610 SSVIKLEEQKSDLERQLKTLTKQMKEETEEWR------------RFQADLQTAVVVANDI 657
S LE+Q +++ QL+ L ++ + TE+ + +F+ DLQ + +
Sbjct: 1525 KSKRALEQQVEEMKTQLEELEDEL-QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEK 1583
Query: 658 KCEAQQELRTVKRKLLEEEEKNA-------RLQKELGDVQGH 692
K + +++R ++ +L +E ++ + +L+ +L D++ H
Sbjct: 1584 KKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAH 1625
Score = 58.2 bits (139), Expect = 3e-08
Identities = 79/326 (24%), Positives = 145/326 (44%), Gaps = 41/326 (12%)
Query: 385 LEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLEL 444
L++ C L+ ++ +L + L R+ EE E++K +++ N E+
Sbjct: 812 LQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEM 871
Query: 445 ERHNNNMMAKTL---EECRVTLEGLKMENGSLKSHLQGEKQKATE-----ASAVEQTAES 496
E + +MA+ L E+ + E L E L++ L +KQ+ E + VE+ E
Sbjct: 872 ETLQSQLMAEKLQLQEQLQAETE-LCAEAEELRARLTAKKQELEEICHDLEARVEEEEER 930
Query: 497 C---------------EVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKV 541
C E++E L+ + + L+L +L K E + K+
Sbjct: 931 CQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKL 990
Query: 542 EKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKET-IFELEDQVEQHRAVKLH 600
K+ L+ D AE T+L +E+ S+S A++K+ E I +LE+++ + +
Sbjct: 991 AKEKKLLE---DRIAE--FTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQR-- 1043
Query: 601 NNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCE 660
ELE + KLE +DL Q+ L Q+ E + + + +LQ A+ + E
Sbjct: 1044 -----QELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEE---E 1095
Query: 661 AQQELRTVKRKLLEEEEKNARLQKEL 686
A Q+ +K K+ E E + + LQ++L
Sbjct: 1096 AAQKNMALK-KIRELESQISELQEDL 1120
Score = 53.9 bits (128), Expect = 5e-07
Identities = 67/328 (20%), Positives = 136/328 (41%), Gaps = 27/328 (8%)
Query: 286 ELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSF 345
E+ L L I +N ++L+ ++ D + + + A E+++
Sbjct: 1616 EMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILA--------- 1666
Query: 346 HQHRERAEQLSQENEKLMNLLQERVKNEEPTTQ-EGKIIELEQKCTGILEQGRFEREKLL 404
Q +E ++L +++ L +E E Q + + EL + +G E+
Sbjct: 1667 -QAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKR 1725
Query: 405 NIQQQLTCSLRKVEEENQGALEMIK-RLKEEN---EKLNEFLELERHNNNMMAKTLEECR 460
++ ++ L + EE QG E+I RLK+ N +++N L LER + A+ E R
Sbjct: 1726 RLEARIA-QLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSH----AQKNENAR 1780
Query: 461 VTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNEL 520
LE E ++G + +AS A+ +++E L E+ + +C ++
Sbjct: 1781 QQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKER---QAACKQV 1837
Query: 521 RQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDM 580
R + ++K V + ++ K+ D + +L + +L+E E+
Sbjct: 1838 R----RTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASR 1893
Query: 581 KETIFELEDQVEQHRAVKLHNNQLISEL 608
++ ELED E A+ + L ++L
Sbjct: 1894 RKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 51.2 bits (121), Expect = 3e-06
Identities = 102/491 (20%), Positives = 190/491 (38%), Gaps = 101/491 (20%)
Query: 67 RTPSTKPKQENEGGEKAALESQVREL-----LAEAKAKDSEINRLRSELKKYKEKRTLNA 121
+T S K +E + E A E + + L L EA + +E+ RL + + E
Sbjct: 1454 KTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMED----- 1508
Query: 122 EGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN 181
L + D S + E RALE++ + + +L +LE+E + ++ + LE +
Sbjct: 1509 -----LMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQ 1563
Query: 182 SEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKA 241
+ A ++ +M +++++ +K S + +
Sbjct: 1564 AMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ----------RSMAVAARK 1613
Query: 242 SLSPDASDFE-HITAETPSRP-----LSSTSNPFKSSKCSTAGSSPNSVSELSLASLTE- 294
L D D E HI + +R L K C + E LA E
Sbjct: 1614 KLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD--CMRELDDTRASREEILAQAKEN 1671
Query: 295 --KIQKMEENHHSTAEELQATLQ----------ELSDQ---------------------- 320
K++ ME EEL A + EL+D+
Sbjct: 1672 EKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARI 1731
Query: 321 QQMVQELTAE--NEKLVDEKTI--------------LETSFHQHRERA-EQLSQENEKLM 363
Q+ +EL E N +L++++ LE S Q E A +QL ++N++L
Sbjct: 1732 AQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELK 1791
Query: 364 NLLQER---VKNEEP---TTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKV 417
LQE VK++ T E KI +LE++ ++ + +++ +++L L +V
Sbjct: 1792 VKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQV 1851
Query: 418 EEENQGALEM----------IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLK 467
++E + A + +K+LK + E+ E + + + + LE+ T + +
Sbjct: 1852 DDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMN 1911
Query: 468 MENGSLKSHLQ 478
E SLK+ L+
Sbjct: 1912 REVSSLKNKLR 1922
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 88.2 bits (217), Expect = 2e-17
Identities = 103/455 (22%), Positives = 199/455 (43%), Gaps = 37/455 (8%)
Query: 255 AETPSRPLSSTSNPFKSSKCSTAG-----SSPNSVSELSLASLTEKIQKMEENHHSTAEE 309
AE LSS+ N K+ S+ N L L +++ ++EE + S
Sbjct: 573 AEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSR 632
Query: 310 LQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLS-------QENEKL 362
++A Q + Q + E E L ++ T LE + E +L +E E++
Sbjct: 633 MEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI 692
Query: 363 MNLLQE-RVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEEN 421
L E R + E TTQ ++ + ++ +L + E+E L+ + L L+ VE +
Sbjct: 693 QKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDR 752
Query: 422 QGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEK 481
Q E ++ L E L L + N+++ T + V ++ + ++ ++ K
Sbjct: 753 QDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLK 812
Query: 482 -QKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAK 540
+ TE S EQ ++ Q +A+AE++ + E KA E K V+ L K
Sbjct: 813 LELDTERSQAEQERDAAARQ----LAQAEQE------GKTALEQQKAAHE-KEVNQLREK 861
Query: 541 VEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRA-VKL 599
EK+ S+ ++ E L R ++L+ + E E++ ++ E Q E ++L
Sbjct: 862 WEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQL 921
Query: 600 HNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKC 659
+ L ++++ +++ +D +QL+ L + MK + + + LQT +
Sbjct: 922 ETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQ------- 974
Query: 660 EAQQELRTVKRK----LLEEEEKNARLQKELGDVQ 690
EAQ+EL+ R+ L +E+++ L ++ D+Q
Sbjct: 975 EAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQ 1009
Score = 82.0 bits (201), Expect = 2e-15
Identities = 99/446 (22%), Positives = 191/446 (42%), Gaps = 55/446 (12%)
Query: 284 VSELSLASLTEKIQKMEENHHSTAEELQATL----QELSDQQQMVQELTAENEKLVDEKT 339
V + L E+ + E++ S +E Q L QEL QQ Q+ + E++ ++
Sbjct: 1782 VLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKAD 1841
Query: 340 ILETSFHQH----RERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQ 395
L+ + Q +ER +L E+ L EE EG+ ++ ++ G L
Sbjct: 1842 ALQGALEQAHMTLKERHGELQDHKEQARRL-------EEELAVEGRRVQALEEVLGDLRA 1894
Query: 396 GRFEREK-LLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAK 454
E+EK LL +QQQ ++ E E + + + + ++ ++ LE R +
Sbjct: 1895 ESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRH 1954
Query: 455 TLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT--AESCEVQEMLKVARAE--- 509
E R E L+ G + LQG++Q E + + ++ A + +Q L +A
Sbjct: 1955 QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQ 2014
Query: 510 -KDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSL---- 564
++ L + E++ + L+ +++ + LA+ +++ + +E EQL SL
Sbjct: 2015 LEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQE-----REQLLEKSLAQRV 2069
Query: 565 ---KLQEKAS----ESDAEIKDMKETIFEL-------EDQVEQHRAVKLHNN-------Q 603
+QEK + + EI+ + +++ EL E ++ + R + NN
Sbjct: 2070 QENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSH 2129
Query: 604 LISELESSVIKLEEQKSDLERQLKTL---TKQMKEETEEWRRFQADLQTAVVVANDIKCE 660
S +E +KL+ + L+R+L+ L +Q + EWR DL ++
Sbjct: 2130 KTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSS 2189
Query: 661 AQQELRTVKRKLLEEEEKNARLQKEL 686
Q+ ++ +LE + + RLQ EL
Sbjct: 2190 LQEVAMFLQASVLERDSEQQRLQDEL 2215
Score = 73.6 bits (179), Expect = 6e-13
Identities = 140/683 (20%), Positives = 265/683 (38%), Gaps = 104/683 (15%)
Query: 69 PSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALG 128
PS + ++ G ++ + A+A S +++L +L K ++ R D L
Sbjct: 1211 PSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTR-------DVLR 1263
Query: 129 PNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASH 188
V DTE + + ++ Q++LS +EE K K ++S SE H
Sbjct: 1264 DQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEE----KSKWEGKQNSLESELMELH 1319
Query: 189 TGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 248
+S + + + R ++ +A+ +
Sbjct: 1320 ETMASLQSRLRR------------------------AELQRMEAQGERELLQAAKENLTA 1355
Query: 249 DFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAE 308
EH+ A +++ TA S+ +E + S E+ Q ++E
Sbjct: 1356 QVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE-EVESERERAQALQEQGELKVA 1414
Query: 309 ELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQE 368
+ +A + L+ Q + E E E L + LE + E LS + +K
Sbjct: 1415 QGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKK------- 1467
Query: 369 RVKNEEPTTQEGKIIELEQKCTGILEQGRF---EREKLLNIQQQLTCSLRKVEEENQGAL 425
+N+E Q+ +I ELE KC +LE ERE+ L +Q++ +R++E++ +
Sbjct: 1468 --RNQEVDLQQEQIQELE-KCRSVLEHLPMAVQEREQKLTVQRE---QIRELEKDRETQR 1521
Query: 426 EMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLE--GLKMENGSLKSHLQG---- 479
+++ E EK ++ +E +R + K L VTLE L++E K Q
Sbjct: 1522 NVLEHQLLELEKKDQMIESQRGQVQDLKKQL----VTLECLALELEENHHKMECQQKLIK 1577
Query: 480 --EKQKATEASAVEQ-TAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSS 536
E Q+ T+ A+ T + E + L+ ++ LE L +EL + + E+K
Sbjct: 1578 ELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE 1637
Query: 537 LLAKVEKDYSYLKEICDHQ-------------------------AEQLSRTSLKLQEKAS 571
+ ++++ +L + + + E L + L L+E+
Sbjct: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGR 1697
Query: 572 ESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI-------KLEEQKSDLER 624
E + + M+E E + + R H ++ + E V +L+E K LE+
Sbjct: 1698 ELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQ 1757
Query: 625 QLKTLTKQMKEET-------EEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEE 677
QL+ L +++ E + +E Q LQ A + Q +L +R L + ++
Sbjct: 1758 QLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ 1817
Query: 678 KNARLQKELGDVQGHGRVVTSRA 700
+ LQ+E QG V +A
Sbjct: 1818 ELEALQQEQQQAQGQEERVKEKA 1840
Score = 73.2 bits (178), Expect = 8e-13
Identities = 97/406 (23%), Positives = 181/406 (44%), Gaps = 61/406 (15%)
Query: 289 LASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQH 348
L + + +I +E + A ELQ QE+ Q++ ++EL + E L
Sbjct: 1604 LQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHL-------------- 1649
Query: 349 RERAEQLSQENEKLMNLLQERVK-NEEPTTQEGKIIE--LEQKCTGILEQGRFEREKLLN 405
+ L + +++LM L +ER++ E+ T++ KI+E LEQ + E+GR E
Sbjct: 1650 ---TQDLERRDQELM-LQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGR-ELTTQRQ 1704
Query: 406 IQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEG 465
+ Q+ + + +G+LE +K + + EK E + H L+
Sbjct: 1705 LMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHE--------------LQE 1750
Query: 466 LKMENGSLKSHLQGEKQKATEASAV--EQTAESCEVQEMLKVARAEKDLLELS----CNE 519
LK L+ LQG +K E S + ++ E +Q+ L+ AR + +L E S +E
Sbjct: 1751 LK---DQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDE 1807
Query: 520 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKD 579
++ L + + E++ + + + +KE D L + + L+E+ E++D
Sbjct: 1808 AQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKER----HGELQD 1863
Query: 580 MKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEE 639
KE LE+++ AV+ + + LE + L + + E+ L L +Q E+ +E
Sbjct: 1864 HKEQARRLEEEL----AVE---GRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQE 1916
Query: 640 WRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKE 685
LQ + + A + E QEL + L E +++R Q+E
Sbjct: 1917 HEVETRALQDSWLQAQAVLKERDQEL-----EALRAESQSSRHQEE 1957
Score = 63.9 bits (154), Expect = 5e-10
Identities = 103/459 (22%), Positives = 198/459 (43%), Gaps = 60/459 (13%)
Query: 292 LTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRER 351
L E ++ ++ + EE + LQ+ D Q+ V++L ++ D + ++E +E
Sbjct: 980 LKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVE------QEV 1033
Query: 352 AEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLT 411
E+L + E N +Q+ ++ E+ + ++E EQ+ + E +++L ++Q +
Sbjct: 1034 QEKLRETQE--YNRIQKELEREKASLTLS-LMEKEQRLLVLQEADSIRQQELSALRQDMQ 1090
Query: 412 CSLRKVEEENQGALEMIKRLKEENE--------KLNEFLELERHNNNMMAKTLEECRVTL 463
+ ++E +E++++ +E E +L E LE + +L
Sbjct: 1091 -EAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKA 1149
Query: 464 EGLKMENGSLKSHLQG---EKQKATEASAVEQTAE--SCEVQEMLKVARAEKDL------ 512
L++ S +S L+ E+Q +A A Q A S Q + V + +L
Sbjct: 1150 AQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDS 1209
Query: 513 ------LELSCNELRQ-----ELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSR 561
LE N R LL A + V+S L K+ +D ++ D +Q+
Sbjct: 1210 APSVWGLEPDQNGARSLFKRGPLLTALSA-EAVASALHKLHQDLWKTQQTRDVLRDQVQ- 1267
Query: 562 TSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSD 621
KL+E+ ++++AE + + +L+ Q+ Q++ K + LES +++L E +
Sbjct: 1268 ---KLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMAS 1324
Query: 622 LERQLKTLTKQMKEETEEWRRFQA----------DLQTAVVVANDIKCEA---QQELRTV 668
L+ +L+ Q E E QA LQ AVV A A +++LRT
Sbjct: 1325 LQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTA 1384
Query: 669 KR--KLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPSL 705
+ KL EE ++ R + + QG +V +A +L
Sbjct: 1385 RSALKLKNEEVESERERAQALQEQGELKVAQGKALQENL 1423
Score = 63.2 bits (152), Expect = 8e-10
Identities = 88/393 (22%), Positives = 170/393 (43%), Gaps = 48/393 (12%)
Query: 286 ELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSF 345
EL L + + QK E+ EEL ++E Q+M+ L A+ + + E L +
Sbjct: 495 ELQLQGDSAQGQKEEQQ-----EELHLAVRERERLQEMLMGLEAKQSESLSELITLREAL 549
Query: 346 HQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLN 405
E L QE ++ L ++ + ++ E + R KL
Sbjct: 550 ESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTE------VADLRAAAVKLSA 603
Query: 406 IQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEG 465
+ + L +L KV G + + +L+EEN+ + +E N + L E E
Sbjct: 604 LNEAL--ALDKV-----GLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREA 656
Query: 466 LKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELL 525
L +N +HL+ + QKA EA A E+Q L+ + EK+ ++ +E R +
Sbjct: 657 LWEKN----THLEAQLQKAEEAGA--------ELQADLRDIQEEKEEIQKKLSESRHQQE 704
Query: 526 KANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIF 585
A +++ + + E+ + + + + +A + +L+++ +A E D + D+ E +
Sbjct: 705 AATTQLEQLHQEAKRQEEVLA--RAVQEKEALVREKAALEVRLQAVERDRQ--DLAEQLQ 760
Query: 586 ELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQA 645
L E L ++ ++ ++SVI E K LE Q++T+T+ + E R +
Sbjct: 761 GLSSAKE-----LLESSLFEAQQQNSVI--EVTKGQLEVQIQTVTQAKEVIQGEVRCLKL 813
Query: 646 DLQTAVVVANDIKCEAQQELRTVKRKLLEEEEK 678
+L T + +A+QE R+L + E++
Sbjct: 814 ELDTE-------RSQAEQERDAAARQLAQAEQE 839
Score = 48.9 bits (115), Expect = 2e-05
Identities = 102/456 (22%), Positives = 193/456 (42%), Gaps = 85/456 (18%)
Query: 308 EELQATLQE--LSDQQQMVQELTAENEKLVDEKTI----------LETSFHQHRERAEQL 355
+ LQ L+E L+ QQQM + A KL + + L+ Q+R ++L
Sbjct: 14 QSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQEL 73
Query: 356 SQENEKLMNLLQERVKN-EEPTTQE--GKIIELEQKCTGILE---QGRFEREKLLNIQQQ 409
+ E + +R +N EEP E ++ E +Q+C + E Q R EK + +
Sbjct: 74 EKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA 133
Query: 410 LTCSLRKVEEENQGALEMIKR---------------LKEENEKL----NEFLELERHNNN 450
L + K+ + A + + R LK E+ +L E + RH
Sbjct: 134 LREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLE 193
Query: 451 MMAKTLEEC-RVTLEGLKMENGSLKSHLQ---GEKQKATEASAVEQTAESCEVQEMLKVA 506
M + T + + E +++ L L+ G + + S E ++ +L +A
Sbjct: 194 MKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQL--LLLLA 251
Query: 507 RAEKDLLELSCNELRQEL--LKANGEIK---------HVSSLLAKVEK---DYSYL---- 548
+ ++ LE +E QEL LK+ G+++ +S+LL + +K DY +
Sbjct: 252 KTQE--LEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKAL 309
Query: 549 -----------KEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAV 597
E+ +H+A LSR + QE+ IKD+ + + E D + Q
Sbjct: 310 RETVEILETNHTELMEHEAS-LSRNA---QEEKLSLQQVIKDITQVMVEEGDNIAQGSG- 364
Query: 598 KLHNNQLISELESSVI-KLEEQKSDLERQL-KTLTKQMKEETEEWRRFQADLQTAVVVAN 655
H N L EL+SS+ + + Q +D L +++ + ++ ++ R+ A Q AV +
Sbjct: 365 --HENSL--ELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQ 420
Query: 656 DIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQG 691
+ ++E + ++++L + + L + D+QG
Sbjct: 421 QQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQG 456
Score = 48.9 bits (115), Expect = 2e-05
Identities = 133/610 (21%), Positives = 243/610 (39%), Gaps = 83/610 (13%)
Query: 74 KQENEGGE--KAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNV 131
++ E GE + +L+SQ+ E +D E+ L+ E ++ + + E DAL +
Sbjct: 1788 QEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGAL 1847
Query: 132 DGTSVSPGDTEPMIRALEEKNKNFQKELS--------------DLEEENRVLKEKLIYLE 177
+ ++ + ++ +E+ + ++EL+ DL E+R ++ L+ L+
Sbjct: 1848 EQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQ 1907
Query: 178 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSD 237
+ A + T Q+S Q + + E + + ALR SS
Sbjct: 1908 -----QQCAEQAQEHEVETRALQDSWL------QAQAVLKERDQEL--EALRAESQSSRH 1954
Query: 238 VTKASLS-----PDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASL 292
+A+ + +A H + + L + +S + STA + SL +
Sbjct: 1955 QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTA------TLQASLDAC 2008
Query: 293 TEKIQKMEENHHSTAEELQ-ATLQELSDQQQMVQELTAENEKL---VDEKTILETSFHQH 348
+++EE E+Q L+ D QQ+ Q L +E+L + + +LE S Q
Sbjct: 2009 QAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQR 2068
Query: 349 RERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELE----QKCTGILE----QGRFER 400
+ E + QE + NL QER + EE + EL+ QK ILE Q R
Sbjct: 2069 VQ--ENMIQEKQ---NLGQER-EEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNL 2122
Query: 401 EKLLNIQQ------------QLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHN 448
E L + + L L++ E Q AL + + E + + L L
Sbjct: 2123 EALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQ 2182
Query: 449 NNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARA 508
+L+E + L+ +E S + LQ E + A E+ +R
Sbjct: 2183 TKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRG 2242
Query: 509 EK--DLLELSCNELR-----QELLKANGEIKHVSSLLAKVEKDYSYLKE---ICDHQAEQ 558
E+ L E+S E E ++H+ +A++E D S L+ EQ
Sbjct: 2243 EQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQ 2302
Query: 559 LSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQH-RAVKLHNNQLISELESSVIKLEE 617
+ R KL+ +A + A+ ++ + +Q R K + + ++EL+ V+ L+
Sbjct: 2303 VERERRKLKREAMRA-AQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQA 2361
Query: 618 QKSDLERQLK 627
Q + LER+ K
Sbjct: 2362 QLT-LERKQK 2370
Score = 48.5 bits (114), Expect = 2e-05
Identities = 95/441 (21%), Positives = 167/441 (37%), Gaps = 58/441 (13%)
Query: 287 LSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFH 346
LSL +++ ++E +EL A Q++ + Q +EL+A+ E L E E F
Sbjct: 1059 LSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADF- 1117
Query: 347 QHRERAEQLSQENEKLMNLLQERVKNEEPT----TQEGKIIELE---------------Q 387
L+QE + L L + ++ QE K +L+ +
Sbjct: 1118 --------LAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAE 1169
Query: 388 KCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRL----KEENEKLNEFLE 443
+ G Q + + L + QQ S+ + E G + + ++N + F
Sbjct: 1170 QQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKR 1229
Query: 444 ---LERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQ--GEKQKATEASAVEQTAESCE 498
L + +A L + L + L+ +Q E+ TEA + E +
Sbjct: 1230 GPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQD 1289
Query: 499 VQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVE---KDYSYLKEICDHQ 555
+Q L + EK E N L EL++ + + + S L + E + +E+
Sbjct: 1290 LQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAA 1349
Query: 556 AEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKL 615
E L+ LQ E+ A+ I E ED A+KL N ++ SE E +
Sbjct: 1350 KENLTAQVEHLQAAVVEARAQAS--AAGILE-EDLRTARSALKLKNEEVESERERAQALQ 1406
Query: 616 EE------QKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVK 669
E+ Q L+ L LT+ + E EE + +Q + E Q+E++
Sbjct: 1407 EQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQ---------ELEKQREMQKAA 1457
Query: 670 RKLLEEEEKNARLQKELGDVQ 690
+LL + K + +L Q
Sbjct: 1458 LELLSLDLKKRNQEVDLQQEQ 1478
Score = 44.3 bits (103), Expect = 4e-04
Identities = 76/347 (21%), Positives = 139/347 (40%), Gaps = 71/347 (20%)
Query: 384 ELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKL-NEFL 442
E Q+ + QG E+ +L + +L+ L + +++N+ +MIK L+E E L
Sbjct: 262 ERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHT 321
Query: 443 ELERHNNNMMAKTLEECRVTL-------------EGLKMENGS-------LKSHL--QGE 480
EL H ++ EE +++L EG + GS L S + Q +
Sbjct: 322 ELMEHEASLSRNAQEE-KLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFD 380
Query: 481 KQKATEASAVEQTA-------------ESCEVQEMLKVARAEKDLLELSCNELRQELLKA 527
Q A +A + ++ + QE + + + + D E LRQ L K
Sbjct: 381 YQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKL 440
Query: 528 NGE-----------------IKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKA 570
GE + LL K ++ E+ + +A +L R +++LQ +
Sbjct: 441 TGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQG 500
Query: 571 SESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLT 630
+ + KE E Q E H AV+ L+ ++ LE ++S+ +L TL
Sbjct: 501 DSAQGQ----KE-----EQQEELHLAVRER-----ERLQEMLMGLEAKQSESLSELITLR 546
Query: 631 KQMKE---ETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLE 674
+ ++ E E R+ Q ++ A+ A E T+K ++ +
Sbjct: 547 EALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVAD 593
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 88.2 bits (217), Expect = 2e-17
Identities = 161/707 (22%), Positives = 289/707 (40%), Gaps = 97/707 (13%)
Query: 74 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 133
KQE E +K LE+QV+EL ++K D E R R+EL K E + +G
Sbjct: 1254 KQEVEH-KKKKLEAQVQEL--QSKCSDGE--RARAELNDKVHKLQNEVESVTGMLNEAEG 1308
Query: 134 TSVSPG-----------DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIY-LEHSPN 181
++ DT+ +++ + N +L LEEE L+++L +E N
Sbjct: 1309 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1368
Query: 182 SEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSS----D 237
E S T + S + F S T + ++K I + +++ +
Sbjct: 1369 LERHIS-TLNIQLSDSKKKLQDFAS-TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426
Query: 238 VTKASLSPDASDFEHITAETPSRPLSST----SNPFKSSKCSTAGSSPNSVSELSLASLT 293
TK L + D + R L S F S E A
Sbjct: 1427 KTKNRLQQELDDL--VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA- 1483
Query: 294 EKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 353
+ ++ E S A L+ L+ + ++ + L AE E LV K + + H+ +
Sbjct: 1484 -EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 354 QLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFER----------EKL 403
L + E++ L+E +++E T++ K+ LE + +G+FER EK
Sbjct: 1543 ALETQMEEMKTQLEE-LEDELQATEDAKL-RLEVNMQAL--KGQFERDLQARDEQNEEKR 1598
Query: 404 LNIQQQLTCSLRKVEEEN-QGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVT 462
+Q+QL ++E+E Q AL + K E + + LEL+ + K EE
Sbjct: 1599 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD--LELQADS---AIKGREEAIKQ 1653
Query: 463 LEGLKMENGSLKSHLQGEKQ---------KATEASAVEQTAESCEVQEMLKVARAEKDLL 513
L L+ + + L+ + K E A A+ ++QE L A +
Sbjct: 1654 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 1713
Query: 514 ELSCNELRQEL---LKANGEIK--------HVSSLLAKVEKDYSYLKEICDH------QA 556
+L EL +EL L ++ ++ L ++E++ ++ + D QA
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773
Query: 557 EQLSRTSLKLQEKASESDAEIKDMKETIFELEDQV-EQHRAVKLHNNQLISELESSVIKL 615
EQLS + A ++++ + ++ EL ++ E AVK I+ LE+ + +L
Sbjct: 1774 EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1833
Query: 616 EEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQ---ELRTVKRKL 672
EEQ R+ + TK +K++ ++ + ++ +A K +A++ ++ +KR+L
Sbjct: 1834 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1893
Query: 673 LEEEEKNAR-------LQKELGDV----QGHGRVVTS-----RAAPP 703
E EE++ R LQ+EL + + GR V + R PP
Sbjct: 1894 EEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1940
Score = 85.1 bits (209), Expect = 2e-16
Identities = 102/466 (21%), Positives = 201/466 (43%), Gaps = 84/466 (18%)
Query: 285 SELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETS 344
+E L L +K ++ E + E+LQA + ++ ++M L A+ ++L + +E
Sbjct: 878 AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR 937
Query: 345 FHQHRERAEQLSQENEKL---MNLLQERVKNE---------EPTTQEGKIIELEQKCTGI 392
+ +R +QL E +K+ M L+E+++ E E T E KI +LE + +
Sbjct: 938 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 997
Query: 393 LEQ-GRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNM 451
+Q + +E+ L ++++++ + EE + A + K LK ++E + LE+
Sbjct: 998 DDQNNKLSKERKL-LEERISDLTTNLAEEEEKAKNLTK-LKNKHESMISELEVRLKKEEK 1055
Query: 452 MAKTLEECRVTLEG------------------LKMENGSLKSHLQGEKQKATEASAVEQT 493
+ LE+ + LEG LKM+ + LQ + + A +
Sbjct: 1056 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1115
Query: 494 A---------ESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV-------SSL 537
A ++QE L RA ++ E +L +EL E++ L
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1175
Query: 538 LAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMK----ETIFELEDQVEQ 593
AK E++ + LK+ D E+ +A++++M+ + + EL +Q+EQ
Sbjct: 1176 RAKREQEVTVLKKALD--------------EETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 594 HRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQ----- 648
+ K + L+ + LE++ +DL +L+ L + +E + ++ +A +Q
Sbjct: 1222 FKRAK-------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274
Query: 649 -----TAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDV 689
A ND + Q E+ +V L E E K +L K++ +
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Score = 82.0 bits (201), Expect = 2e-15
Identities = 91/393 (23%), Positives = 180/393 (45%), Gaps = 49/393 (12%)
Query: 295 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 354
++ + EE + +ELQ T + + ++EL ++ +L +EK +L+ EQ
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ----------EQ 902
Query: 355 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 414
L E E + RV ++ +Q+ IL + E+ + QQL
Sbjct: 903 LQAETELYAEAEEMRV----------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 952
Query: 415 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 474
+K+ ++ L++ ++L+EE E + L+LE+ K LE+ E L M++ +
Sbjct: 953 KKMAQQ---MLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLED-----EILVMDD---Q 1000
Query: 475 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV 534
++ +++K E + T E +E K K+ E +EL L K + +
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1060
Query: 535 SSLLAKVEKDYS-YLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQ 593
L K+E D S + ++I D QA Q++ ++L +K E A + + + I + + +++
Sbjct: 1061 EKLKRKLEGDASDFHEQIADLQA-QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 594 HRAVKLHNNQLISELESSVI---KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 650
R ++ H + L +L+S K E+QK DL +L+ L +++ D +
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-----------DTLDS 1168
Query: 651 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQ 683
+++ + +QE+ TV +K L+EE ++ Q
Sbjct: 1169 TATQQELRAKREQEV-TVLKKALDEETRSHEAQ 1200
Score = 78.6 bits (192), Expect = 2e-14
Identities = 141/664 (21%), Positives = 259/664 (39%), Gaps = 99/664 (14%)
Query: 81 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEK---RTLNAEGTDALGPNVDGTSVS 137
EK E+++++L E D + N+L E K +E+ T N + N+
Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK-- 1036
Query: 138 PGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAAS--HTGDSSCP 195
E MI LE + K +K +LE+ LK KL EG AS H +
Sbjct: 1037 -NKHESMISELEVRLKKEEKSRQELEK----LKRKL---------EGDASDFHEQIADLQ 1082
Query: 196 TSITQESSFGSPTGNQMSSDIDEYKKNI--HGNALRTSGSSSSDVTKASLSPDASDFEHI 253
I + + ++ + + I NAL+ ++ D+
Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1142
Query: 254 TAETPSRPLSSTSNPFKSSKCSTAGSSPNS----------VSELSLA------SLTEKIQ 297
AE R L K+ T S+ V+ L A S ++Q
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 298 KMEENHHSTAEELQATLQEL----SDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 353
+M + H EEL L++ ++ + Q L EN L E +L Q ++ E
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG----QAKQEVE 1258
Query: 354 QLSQENEKLMNLLQERVKNEEPTTQE--GKIIELE---QKCTGILEQGRFEREKLLNIQQ 408
++ E + LQ + + E E K+ +L+ + TG+L + + KL
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1318
Query: 409 QLTCSLRKVEEENQGALEMIKRLKEENEKLN---EFLELERHNNNMMAKTLEECRVTLEG 465
L+ L+ +E Q +E +KLN + +LE N++ + EE +
Sbjct: 1319 SLSSQLQDTQELLQ---------EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK-QN 1368
Query: 466 LKMENGSLKSHLQGEKQKATE-ASAVEQTAESCE--------VQEMLKVARAEKDLLELS 516
L+ +L L K+K + AS VE E + + + + A D LE +
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1428
Query: 517 CNELRQELLKANGEIKHVSSLLAKVEKDYSYL-------KEICDHQAEQLSRTSLKLQEK 569
N L+QEL ++ + L++ +EK K I A++ R + +EK
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 570 ASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLIS---ELESSVIKLEEQKSDLERQL 626
+++ + + ++E + E+ ++ +K L+S ++ +V +LE+ K LE Q+
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548
Query: 627 KTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVK----RKLLEEEEKNARL 682
+ + Q++E L+ + D K + ++ +K R L +E+N
Sbjct: 1549 EEMKTQLEE-----------LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 683 QKEL 686
+++L
Sbjct: 1598 RRQL 1601
Score = 65.1 bits (157), Expect = 2e-10
Identities = 62/282 (21%), Positives = 125/282 (44%), Gaps = 26/282 (9%)
Query: 414 LRKVEEENQGALEMIKRLKEENEKLNE---FLELERHNNNMMAKTLEECRVTLEGLKMEN 470
L+K +E Q A +K L++++ +L E L+ + + EE RV L K E
Sbjct: 868 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 927
Query: 471 GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 530
+ ++ ++ + Q Q+ML + E+ L E + +L K E
Sbjct: 928 EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL---EEQLEEEEAARQKLQLEKVTAE 984
Query: 531 IKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQ 590
K + K+E + + D Q +LS+ L+E+ I D+ + E E++
Sbjct: 985 AK-----IKKLEDEIL----VMDDQNNKLSKERKLLEER-------ISDLTTNLAEEEEK 1028
Query: 591 VEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 650
+ +K + +ISELE + K E+ + +LE+ L ++++ + ++ ADLQ
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEK----LKRKLEGDASDFHEQIADLQAQ 1084
Query: 651 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGH 692
+ + ++EL+ +L +E + K++ +++GH
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1126
Score = 55.8 bits (133), Expect = 1e-07
Identities = 86/441 (19%), Positives = 189/441 (42%), Gaps = 41/441 (9%)
Query: 72 KPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNV 131
K + E+ K + V EL +A ++++ ++++L++ +++ + L N+
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1576
Query: 132 DGTSVSPGDTEPMIRALEEKNKNFQKEL--------SDLEEENRVLKEKLIYLEHSPNSE 183
G E ++A +E+N+ +++L ++LE+E K++ + E
Sbjct: 1577 QALK---GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER---KQRALAAAAKKKLE 1630
Query: 184 GAASHTGDSSCPTSITQESSFGSPTGNQMS-SDIDEYKKNIHGNALRTSGSSSSDVTKA- 241
G + +E + Q D ++ + ++ + KA
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690
Query: 242 SLSPDASDF-EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME 300
SL D E + A +R + + + +++ S N++ + L +I ++E
Sbjct: 1691 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD-EKRRLEARIAQLE 1749
Query: 301 ENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENE 360
E EE Q ++ +SD+ V++ T + E+L +E ++ ++ +QL ++N+
Sbjct: 1750 EE----LEEEQGNMEAMSDR---VRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1802
Query: 361 KLMNLLQER---VKNEEPTT---QEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 414
+L + L E VK++ +T E KI +LE++ + + + L ++L L
Sbjct: 1803 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862
Query: 415 RKVEEENQGALEM----------IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLE 464
+VE+E + A + +K+LK + E+ E + N + + L+E + E
Sbjct: 1863 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Query: 465 GLKMENGSLKSHLQGEKQKAT 485
+ E +LKS L+G + T
Sbjct: 1923 AMGREVNALKSKLRGPPPQET 1943
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 88.2 bits (217), Expect = 2e-17
Identities = 161/707 (22%), Positives = 289/707 (40%), Gaps = 97/707 (13%)
Query: 74 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 133
KQE E +K LE+QV+EL ++K D E R R+EL K E + +G
Sbjct: 1247 KQEVEH-KKKKLEAQVQEL--QSKCSDGE--RARAELNDKVHKLQNEVESVTGMLNEAEG 1301
Query: 134 TSVSPG-----------DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIY-LEHSPN 181
++ DT+ +++ + N +L LEEE L+++L +E N
Sbjct: 1302 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1361
Query: 182 SEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSS----D 237
E S T + S + F S T + ++K I + +++ +
Sbjct: 1362 LERHIS-TLNIQLSDSKKKLQDFAS-TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419
Query: 238 VTKASLSPDASDFEHITAETPSRPLSST----SNPFKSSKCSTAGSSPNSVSELSLASLT 293
TK L + D + R L S F S E A
Sbjct: 1420 KTKNRLQQELDDL--VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA- 1476
Query: 294 EKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 353
+ ++ E S A L+ L+ + ++ + L AE E LV K + + H+ +
Sbjct: 1477 -EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 354 QLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFER----------EKL 403
L + E++ L+E +++E T++ K+ LE + +G+FER EK
Sbjct: 1536 ALETQMEEMKTQLEE-LEDELQATEDAKL-RLEVNMQAL--KGQFERDLQARDEQNEEKR 1591
Query: 404 LNIQQQLTCSLRKVEEEN-QGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVT 462
+Q+QL ++E+E Q AL + K E + + LEL+ + K EE
Sbjct: 1592 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD--LELQADS---AIKGREEAIKQ 1646
Query: 463 LEGLKMENGSLKSHLQGEKQ---------KATEASAVEQTAESCEVQEMLKVARAEKDLL 513
L L+ + + L+ + K E A A+ ++QE L A +
Sbjct: 1647 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 1706
Query: 514 ELSCNELRQEL---LKANGEIK--------HVSSLLAKVEKDYSYLKEICDH------QA 556
+L EL +EL L ++ ++ L ++E++ ++ + D QA
Sbjct: 1707 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766
Query: 557 EQLSRTSLKLQEKASESDAEIKDMKETIFELEDQV-EQHRAVKLHNNQLISELESSVIKL 615
EQLS + A ++++ + ++ EL ++ E AVK I+ LE+ + +L
Sbjct: 1767 EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1826
Query: 616 EEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQ---ELRTVKRKL 672
EEQ R+ + TK +K++ ++ + ++ +A K +A++ ++ +KR+L
Sbjct: 1827 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1886
Query: 673 LEEEEKNAR-------LQKELGDV----QGHGRVVTS-----RAAPP 703
E EE++ R LQ+EL + + GR V + R PP
Sbjct: 1887 EEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1933
Score = 85.1 bits (209), Expect = 2e-16
Identities = 102/466 (21%), Positives = 201/466 (43%), Gaps = 84/466 (18%)
Query: 285 SELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETS 344
+E L L +K ++ E + E+LQA + ++ ++M L A+ ++L + +E
Sbjct: 871 AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR 930
Query: 345 FHQHRERAEQLSQENEKL---MNLLQERVKNE---------EPTTQEGKIIELEQKCTGI 392
+ +R +QL E +K+ M L+E+++ E E T E KI +LE + +
Sbjct: 931 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 990
Query: 393 LEQ-GRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNM 451
+Q + +E+ L ++++++ + EE + A + K LK ++E + LE+
Sbjct: 991 DDQNNKLSKERKL-LEERISDLTTNLAEEEEKAKNLTK-LKNKHESMISELEVRLKKEEK 1048
Query: 452 MAKTLEECRVTLEG------------------LKMENGSLKSHLQGEKQKATEASAVEQT 493
+ LE+ + LEG LKM+ + LQ + + A +
Sbjct: 1049 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1108
Query: 494 A---------ESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV-------SSL 537
A ++QE L RA ++ E +L +EL E++ L
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168
Query: 538 LAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMK----ETIFELEDQVEQ 593
AK E++ + LK+ D E+ +A++++M+ + + EL +Q+EQ
Sbjct: 1169 RAKREQEVTVLKKALD--------------EETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 594 HRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQ----- 648
+ K + L+ + LE++ +DL +L+ L + +E + ++ +A +Q
Sbjct: 1215 FKRAK-------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267
Query: 649 -----TAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDV 689
A ND + Q E+ +V L E E K +L K++ +
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Score = 82.0 bits (201), Expect = 2e-15
Identities = 91/393 (23%), Positives = 180/393 (45%), Gaps = 49/393 (12%)
Query: 295 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 354
++ + EE + +ELQ T + + ++EL ++ +L +EK +L+ EQ
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ----------EQ 895
Query: 355 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 414
L E E + RV ++ +Q+ IL + E+ + QQL
Sbjct: 896 LQAETELYAEAEEMRV----------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 945
Query: 415 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 474
+K+ ++ L++ ++L+EE E + L+LE+ K LE+ E L M++ +
Sbjct: 946 KKMAQQ---MLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLED-----EILVMDD---Q 993
Query: 475 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV 534
++ +++K E + T E +E K K+ E +EL L K + +
Sbjct: 994 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1053
Query: 535 SSLLAKVEKDYS-YLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQ 593
L K+E D S + ++I D QA Q++ ++L +K E A + + + I + + +++
Sbjct: 1054 EKLKRKLEGDASDFHEQIADLQA-QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 594 HRAVKLHNNQLISELESSVI---KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 650
R ++ H + L +L+S K E+QK DL +L+ L +++ D +
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-----------DTLDS 1161
Query: 651 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQ 683
+++ + +QE+ TV +K L+EE ++ Q
Sbjct: 1162 TATQQELRAKREQEV-TVLKKALDEETRSHEAQ 1193
Score = 78.6 bits (192), Expect = 2e-14
Identities = 141/664 (21%), Positives = 259/664 (39%), Gaps = 99/664 (14%)
Query: 81 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEK---RTLNAEGTDALGPNVDGTSVS 137
EK E+++++L E D + N+L E K +E+ T N + N+
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK-- 1029
Query: 138 PGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAAS--HTGDSSCP 195
E MI LE + K +K +LE+ LK KL EG AS H +
Sbjct: 1030 -NKHESMISELEVRLKKEEKSRQELEK----LKRKL---------EGDASDFHEQIADLQ 1075
Query: 196 TSITQESSFGSPTGNQMSSDIDEYKKNI--HGNALRTSGSSSSDVTKASLSPDASDFEHI 253
I + + ++ + + I NAL+ ++ D+
Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1135
Query: 254 TAETPSRPLSSTSNPFKSSKCSTAGSSPNS----------VSELSLA------SLTEKIQ 297
AE R L K+ T S+ V+ L A S ++Q
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 298 KMEENHHSTAEELQATLQEL----SDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 353
+M + H EEL L++ ++ + Q L EN L E +L Q ++ E
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG----QAKQEVE 1251
Query: 354 QLSQENEKLMNLLQERVKNEEPTTQE--GKIIELE---QKCTGILEQGRFEREKLLNIQQ 408
++ E + LQ + + E E K+ +L+ + TG+L + + KL
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1311
Query: 409 QLTCSLRKVEEENQGALEMIKRLKEENEKLN---EFLELERHNNNMMAKTLEECRVTLEG 465
L+ L+ +E Q +E +KLN + +LE N++ + EE +
Sbjct: 1312 SLSSQLQDTQELLQ---------EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK-QN 1361
Query: 466 LKMENGSLKSHLQGEKQKATE-ASAVEQTAESCE--------VQEMLKVARAEKDLLELS 516
L+ +L L K+K + AS VE E + + + + A D LE +
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1421
Query: 517 CNELRQELLKANGEIKHVSSLLAKVEKDYSYL-------KEICDHQAEQLSRTSLKLQEK 569
N L+QEL ++ + L++ +EK K I A++ R + +EK
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 570 ASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLIS---ELESSVIKLEEQKSDLERQL 626
+++ + + ++E + E+ ++ +K L+S ++ +V +LE+ K LE Q+
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541
Query: 627 KTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVK----RKLLEEEEKNARL 682
+ + Q++E L+ + D K + ++ +K R L +E+N
Sbjct: 1542 EEMKTQLEE-----------LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 683 QKEL 686
+++L
Sbjct: 1591 RRQL 1594
Score = 65.1 bits (157), Expect = 2e-10
Identities = 62/282 (21%), Positives = 125/282 (44%), Gaps = 26/282 (9%)
Query: 414 LRKVEEENQGALEMIKRLKEENEKLNE---FLELERHNNNMMAKTLEECRVTLEGLKMEN 470
L+K +E Q A +K L++++ +L E L+ + + EE RV L K E
Sbjct: 861 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 920
Query: 471 GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 530
+ ++ ++ + Q Q+ML + E+ L E + +L K E
Sbjct: 921 EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL---EEQLEEEEAARQKLQLEKVTAE 977
Query: 531 IKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQ 590
K + K+E + + D Q +LS+ L+E+ I D+ + E E++
Sbjct: 978 AK-----IKKLEDEIL----VMDDQNNKLSKERKLLEER-------ISDLTTNLAEEEEK 1021
Query: 591 VEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 650
+ +K + +ISELE + K E+ + +LE+ L ++++ + ++ ADLQ
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEK----LKRKLEGDASDFHEQIADLQAQ 1077
Query: 651 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGH 692
+ + ++EL+ +L +E + K++ +++GH
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1119
Score = 55.8 bits (133), Expect = 1e-07
Identities = 86/441 (19%), Positives = 189/441 (42%), Gaps = 41/441 (9%)
Query: 72 KPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNV 131
K + E+ K + V EL +A ++++ ++++L++ +++ + L N+
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1569
Query: 132 DGTSVSPGDTEPMIRALEEKNKNFQKEL--------SDLEEENRVLKEKLIYLEHSPNSE 183
G E ++A +E+N+ +++L ++LE+E K++ + E
Sbjct: 1570 QALK---GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER---KQRALAAAAKKKLE 1623
Query: 184 GAASHTGDSSCPTSITQESSFGSPTGNQMS-SDIDEYKKNIHGNALRTSGSSSSDVTKA- 241
G + +E + Q D ++ + ++ + KA
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683
Query: 242 SLSPDASDF-EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME 300
SL D E + A +R + + + +++ S N++ + L +I ++E
Sbjct: 1684 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD-EKRRLEARIAQLE 1742
Query: 301 ENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENE 360
E EE Q ++ +SD+ V++ T + E+L +E ++ ++ +QL ++N+
Sbjct: 1743 EE----LEEEQGNMEAMSDR---VRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1795
Query: 361 KLMNLLQER---VKNEEPTT---QEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 414
+L + L E VK++ +T E KI +LE++ + + + L ++L L
Sbjct: 1796 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855
Query: 415 RKVEEENQGALEM----------IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLE 464
+VE+E + A + +K+LK + E+ E + N + + L+E + E
Sbjct: 1856 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Query: 465 GLKMENGSLKSHLQGEKQKAT 485
+ E +LKS L+G + T
Sbjct: 1916 AMGREVNALKSKLRGPPPQET 1936
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 87.8 bits (216), Expect = 3e-17
Identities = 155/683 (22%), Positives = 281/683 (41%), Gaps = 88/683 (12%)
Query: 74 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 133
KQE E +K LE+QV+EL ++K D E R R+EL K E + +G
Sbjct: 1247 KQEVEH-KKKKLEAQVQEL--QSKCSDGE--RARAELNDKVHKLQNEVESVTGMLNEAEG 1301
Query: 134 TSVSPG-----------DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIY-LEHSPN 181
++ DT+ +++ + N +L LEEE L+++L +E N
Sbjct: 1302 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1361
Query: 182 SEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSS----D 237
E S T + S + F S T + ++K I + +++ +
Sbjct: 1362 LERHIS-TLNIQLSDSKKKLQDFAS-TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419
Query: 238 VTKASLSPDASDFEHITAETPSRPLSST----SNPFKSSKCSTAGSSPNSVSELSLASLT 293
TK L + D + R L S F S E A
Sbjct: 1420 KTKNRLQQELDDL--VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA- 1476
Query: 294 EKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 353
+ ++ E S A L+ L+ + ++ + L AE E LV K + + H+ +
Sbjct: 1477 -EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 354 QLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFER----------EKL 403
L + E++ L+E +++E T++ K+ LE + +G+FER EK
Sbjct: 1536 ALETQMEEMKTQLEE-LEDELQATEDAKL-RLEVNMQAL--KGQFERDLQARDEQNEEKR 1591
Query: 404 LNIQQQLTCSLRKVEEEN-QGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVT 462
+Q+QL ++E+E Q AL + K E + + LEL+ + K EE
Sbjct: 1592 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD--LELQADS---AIKGREEAIKQ 1646
Query: 463 LEGLKMENGSLKSHLQGEKQ---------KATEASAVEQTAESCEVQEMLKVARAEKDLL 513
L L+ + + L+ + K E A A+ ++QE L A +
Sbjct: 1647 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 1706
Query: 514 ELSCNELRQEL---LKANGEIK--------HVSSLLAKVEKDYSYLKEICDH------QA 556
+L EL +EL L ++ ++ L ++E++ ++ + D QA
Sbjct: 1707 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766
Query: 557 EQLSRTSLKLQEKASESDAEIKDMKETIFELEDQV-EQHRAVKLHNNQLISELESSVIKL 615
EQLS + A ++++ + ++ EL ++ E AVK I+ LE+ + +L
Sbjct: 1767 EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1826
Query: 616 EEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQ---ELRTVKRKL 672
EEQ R+ + TK +K++ ++ + ++ +A K +A++ ++ +KR+L
Sbjct: 1827 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1886
Query: 673 LEEEEKNAR-------LQKELGD 688
E EE++ R LQ+EL +
Sbjct: 1887 EEAEEESQRINANRRKLQRELDE 1909
Score = 85.1 bits (209), Expect = 2e-16
Identities = 102/466 (21%), Positives = 201/466 (43%), Gaps = 84/466 (18%)
Query: 285 SELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETS 344
+E L L +K ++ E + E+LQA + ++ ++M L A+ ++L + +E
Sbjct: 871 AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR 930
Query: 345 FHQHRERAEQLSQENEKL---MNLLQERVKNE---------EPTTQEGKIIELEQKCTGI 392
+ +R +QL E +K+ M L+E+++ E E T E KI +LE + +
Sbjct: 931 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 990
Query: 393 LEQ-GRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNM 451
+Q + +E+ L ++++++ + EE + A + K LK ++E + LE+
Sbjct: 991 DDQNNKLSKERKL-LEERISDLTTNLAEEEEKAKNLTK-LKNKHESMISELEVRLKKEEK 1048
Query: 452 MAKTLEECRVTLEG------------------LKMENGSLKSHLQGEKQKATEASAVEQT 493
+ LE+ + LEG LKM+ + LQ + + A +
Sbjct: 1049 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1108
Query: 494 A---------ESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV-------SSL 537
A ++QE L RA ++ E +L +EL E++ L
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168
Query: 538 LAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMK----ETIFELEDQVEQ 593
AK E++ + LK+ D E+ +A++++M+ + + EL +Q+EQ
Sbjct: 1169 RAKREQEVTVLKKALD--------------EETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 594 HRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQ----- 648
+ K + L+ + LE++ +DL +L+ L + +E + ++ +A +Q
Sbjct: 1215 FKRAK-------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267
Query: 649 -----TAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDV 689
A ND + Q E+ +V L E E K +L K++ +
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Score = 82.0 bits (201), Expect = 2e-15
Identities = 91/393 (23%), Positives = 180/393 (45%), Gaps = 49/393 (12%)
Query: 295 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 354
++ + EE + +ELQ T + + ++EL ++ +L +EK +L+ EQ
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ----------EQ 895
Query: 355 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 414
L E E + RV ++ +Q+ IL + E+ + QQL
Sbjct: 896 LQAETELYAEAEEMRV----------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 945
Query: 415 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 474
+K+ ++ L++ ++L+EE E + L+LE+ K LE+ E L M++ +
Sbjct: 946 KKMAQQ---MLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLED-----EILVMDD---Q 993
Query: 475 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV 534
++ +++K E + T E +E K K+ E +EL L K + +
Sbjct: 994 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1053
Query: 535 SSLLAKVEKDYS-YLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQ 593
L K+E D S + ++I D QA Q++ ++L +K E A + + + I + + +++
Sbjct: 1054 EKLKRKLEGDASDFHEQIADLQA-QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 594 HRAVKLHNNQLISELESSVI---KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 650
R ++ H + L +L+S K E+QK DL +L+ L +++ D +
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-----------DTLDS 1161
Query: 651 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQ 683
+++ + +QE+ TV +K L+EE ++ Q
Sbjct: 1162 TATQQELRAKREQEV-TVLKKALDEETRSHEAQ 1193
Score = 78.6 bits (192), Expect = 2e-14
Identities = 141/664 (21%), Positives = 259/664 (39%), Gaps = 99/664 (14%)
Query: 81 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEK---RTLNAEGTDALGPNVDGTSVS 137
EK E+++++L E D + N+L E K +E+ T N + N+
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK-- 1029
Query: 138 PGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAAS--HTGDSSCP 195
E MI LE + K +K +LE+ LK KL EG AS H +
Sbjct: 1030 -NKHESMISELEVRLKKEEKSRQELEK----LKRKL---------EGDASDFHEQIADLQ 1075
Query: 196 TSITQESSFGSPTGNQMSSDIDEYKKNI--HGNALRTSGSSSSDVTKASLSPDASDFEHI 253
I + + ++ + + I NAL+ ++ D+
Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1135
Query: 254 TAETPSRPLSSTSNPFKSSKCSTAGSSPNS----------VSELSLA------SLTEKIQ 297
AE R L K+ T S+ V+ L A S ++Q
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 298 KMEENHHSTAEELQATLQEL----SDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 353
+M + H EEL L++ ++ + Q L EN L E +L Q ++ E
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG----QAKQEVE 1251
Query: 354 QLSQENEKLMNLLQERVKNEEPTTQE--GKIIELE---QKCTGILEQGRFEREKLLNIQQ 408
++ E + LQ + + E E K+ +L+ + TG+L + + KL
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1311
Query: 409 QLTCSLRKVEEENQGALEMIKRLKEENEKLN---EFLELERHNNNMMAKTLEECRVTLEG 465
L+ L+ +E Q +E +KLN + +LE N++ + EE +
Sbjct: 1312 SLSSQLQDTQELLQ---------EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK-QN 1361
Query: 466 LKMENGSLKSHLQGEKQKATE-ASAVEQTAESCE--------VQEMLKVARAEKDLLELS 516
L+ +L L K+K + AS VE E + + + + A D LE +
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1421
Query: 517 CNELRQELLKANGEIKHVSSLLAKVEKDYSYL-------KEICDHQAEQLSRTSLKLQEK 569
N L+QEL ++ + L++ +EK K I A++ R + +EK
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 570 ASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLIS---ELESSVIKLEEQKSDLERQL 626
+++ + + ++E + E+ ++ +K L+S ++ +V +LE+ K LE Q+
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541
Query: 627 KTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVK----RKLLEEEEKNARL 682
+ + Q++E L+ + D K + ++ +K R L +E+N
Sbjct: 1542 EEMKTQLEE-----------LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 683 QKEL 686
+++L
Sbjct: 1591 RRQL 1594
Score = 71.6 bits (174), Expect = 2e-12
Identities = 127/617 (20%), Positives = 252/617 (40%), Gaps = 73/617 (11%)
Query: 71 TKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPN 130
T+ + E +K + +++R+L + E N L+ +L + E + L
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQL-------EEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 131 VDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTG 190
+ + D + ALEE K FQKE+ +L ++ +EK + ++
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ---YEEKAAAYDKLEKTKNRLQQEL 1429
Query: 191 DSSCPTSITQESSFGSPTGNQMSSD-IDEYKKNIHGNAL----RTSGSSSSDVTKASLSP 245
D Q + Q D + +KNI R + TKA LS
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA-LSL 1488
Query: 246 DASDFEHITA----ETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEE 301
+ E + A E ++ L + SSK G + + + E S +L ++++M+
Sbjct: 1489 ARALEEALEAKEELERTNKMLKAEMEDLVSSK-DDVGKNVHEL-EKSKRALETQMEEMKT 1546
Query: 302 NHHSTAEELQAT----------LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRER 351
+ELQAT +Q L Q + ++L A +E+ +++ L+ H++
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQARDEQNEEKRRQLQRQLHEYETE 1604
Query: 352 AEQLSQEN-------EKLMNLLQE-------RVKNEEPTTQEGKIIELEQK-CTGILEQG 396
E ++ +KL L++ +K E ++ + ++ + K LE
Sbjct: 1605 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1664
Query: 397 RFEREKLLNIQQQ-------LTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNN 449
R R+++ ++ L L +++E+ A K+ E E+L E L
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 450 NMMA--KTLEECRVTL--EGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKV 505
N + K E R+ E L+ E G++++ + +KAT+ A + + E + +
Sbjct: 1725 NALQDEKRRLEARIAQLEEELEEEQGNMEA-MSDRVRKATQ-QAEQLSNELATERSTAQK 1782
Query: 506 ARAEKDLLELSCNELRQELLKANGEIKH-VSSLLAKVEKDYSYLKEICDHQAEQLSRTSL 564
+ + LE ELR +L + G +K S +A +E + L+E + +A + +
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 565 KLQEKASESDAEIKDMKETIFELEDQ---VEQHRAVKLHNNQLISELESSVIKLEEQKSD 621
L++K K +KE + ++ED+ EQ++ N + +L+ + + EE+
Sbjct: 1843 SLKQKD-------KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Query: 622 LERQLKTLTKQMKEETE 638
+ + L +++ E TE
Sbjct: 1896 INANRRKLQRELDEATE 1912
Score = 65.1 bits (157), Expect = 2e-10
Identities = 62/282 (21%), Positives = 125/282 (44%), Gaps = 26/282 (9%)
Query: 414 LRKVEEENQGALEMIKRLKEENEKLNE---FLELERHNNNMMAKTLEECRVTLEGLKMEN 470
L+K +E Q A +K L++++ +L E L+ + + EE RV L K E
Sbjct: 861 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 920
Query: 471 GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 530
+ ++ ++ + Q Q+ML + E+ L E + +L K E
Sbjct: 921 EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL---EEQLEEEEAARQKLQLEKVTAE 977
Query: 531 IKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQ 590
K + K+E + + D Q +LS+ L+E+ I D+ + E E++
Sbjct: 978 AK-----IKKLEDEIL----VMDDQNNKLSKERKLLEER-------ISDLTTNLAEEEEK 1021
Query: 591 VEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 650
+ +K + +ISELE + K E+ + +LE+ L ++++ + ++ ADLQ
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEK----LKRKLEGDASDFHEQIADLQAQ 1077
Query: 651 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGH 692
+ + ++EL+ +L +E + K++ +++GH
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1119
Score = 52.8 bits (125), Expect = 1e-06
Identities = 84/434 (19%), Positives = 186/434 (42%), Gaps = 41/434 (9%)
Query: 72 KPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNV 131
K + E+ K + V EL +A ++++ ++++L++ +++ + L N+
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1569
Query: 132 DGTSVSPGDTEPMIRALEEKNKNFQKEL--------SDLEEENRVLKEKLIYLEHSPNSE 183
G E ++A +E+N+ +++L ++LE+E K++ + E
Sbjct: 1570 QALK---GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER---KQRALAAAAKKKLE 1623
Query: 184 GAASHTGDSSCPTSITQESSFGSPTGNQMS-SDIDEYKKNIHGNALRTSGSSSSDVTKA- 241
G + +E + Q D ++ + ++ + KA
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683
Query: 242 SLSPDASDF-EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME 300
SL D E + A +R + + + +++ S N++ + L +I ++E
Sbjct: 1684 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD-EKRRLEARIAQLE 1742
Query: 301 ENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENE 360
E EE Q ++ +SD+ V++ T + E+L +E ++ ++ +QL ++N+
Sbjct: 1743 EE----LEEEQGNMEAMSDR---VRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1795
Query: 361 KLMNLLQER---VKNEEPTT---QEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 414
+L + L E VK++ +T E KI +LE++ + + + L ++L L
Sbjct: 1796 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855
Query: 415 RKVEEENQGALEM----------IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLE 464
+VE+E + A + +K+LK + E+ E + N + + L+E + E
Sbjct: 1856 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Query: 465 GLKMENGSLKSHLQ 478
+ E +LKS L+
Sbjct: 1916 AMGREVNALKSKLR 1929
Score = 52.4 bits (124), Expect = 1e-06
Identities = 111/597 (18%), Positives = 238/597 (39%), Gaps = 65/597 (10%)
Query: 28 REFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALES 87
++F+ TV ++ G +K + + T + + TK + + E +
Sbjct: 1381 QDFASTVE---ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437
Query: 88 QVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRA 147
R+L++ + K + ++L +E K K + +A + ++S + RA
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS------LARA 1491
Query: 148 LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSP 207
LEE + KE +LE N++LK ++ L S + G H + S TQ +
Sbjct: 1492 LEEALE--AKE--ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 208 TGNQMSSDI---DEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSS 264
++ ++ ++ K + N G D+ A D ++ E R L
Sbjct: 1548 L-EELEDELQATEDAKLRLEVNMQALKGQFERDL-------QARDEQN---EEKRRQLQR 1596
Query: 265 TSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMV 324
+ +++ +++ + L ++ +E S + + +++L Q +
Sbjct: 1597 QLHEYETELEDER--KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1654
Query: 325 QELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQ--ERVKNEEPTTQEGKI 382
++ E E + + + ++ ++A+ L + +L L ER + + +E
Sbjct: 1655 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1714
Query: 383 IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEE---NQGALEM----IKRLKEEN 435
EL +G R L + +++L + ++EEE QG +E +++ ++
Sbjct: 1715 EELASSLSG--------RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766
Query: 436 EKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAE 495
E+L+ L ER A+ E R LE E S ++G + +++ A+
Sbjct: 1767 EQLSNELATERST----AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822
Query: 496 SCEVQEMLKVARAEKDLLELSCNE----LRQELLKANGEIKHVSSLLAKVEKDYSYLKEI 551
+++E ++ EK S + L++ LL+ E K + EK + +K
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK-- 1880
Query: 552 CDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISEL 608
QL R + +E++ +A + ++ EL++ E + A+ N L S+L
Sbjct: 1881 ------QLKRQLEEAEEESQRINANRRKLQR---ELDEATESNEAMGREVNALKSKL 1928
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 87.8 bits (216), Expect = 3e-17
Identities = 155/683 (22%), Positives = 281/683 (41%), Gaps = 88/683 (12%)
Query: 74 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 133
KQE E +K LE+QV+EL ++K D E R R+EL K E + +G
Sbjct: 1254 KQEVEH-KKKKLEAQVQEL--QSKCSDGE--RARAELNDKVHKLQNEVESVTGMLNEAEG 1308
Query: 134 TSVSPG-----------DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIY-LEHSPN 181
++ DT+ +++ + N +L LEEE L+++L +E N
Sbjct: 1309 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1368
Query: 182 SEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSS----D 237
E S T + S + F S T + ++K I + +++ +
Sbjct: 1369 LERHIS-TLNIQLSDSKKKLQDFAS-TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426
Query: 238 VTKASLSPDASDFEHITAETPSRPLSST----SNPFKSSKCSTAGSSPNSVSELSLASLT 293
TK L + D + R L S F S E A
Sbjct: 1427 KTKNRLQQELDDL--VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA- 1483
Query: 294 EKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 353
+ ++ E S A L+ L+ + ++ + L AE E LV K + + H+ +
Sbjct: 1484 -EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 354 QLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFER----------EKL 403
L + E++ L+E +++E T++ K+ LE + +G+FER EK
Sbjct: 1543 ALETQMEEMKTQLEE-LEDELQATEDAKL-RLEVNMQAL--KGQFERDLQARDEQNEEKR 1598
Query: 404 LNIQQQLTCSLRKVEEEN-QGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVT 462
+Q+QL ++E+E Q AL + K E + + LEL+ + K EE
Sbjct: 1599 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD--LELQADS---AIKGREEAIKQ 1653
Query: 463 LEGLKMENGSLKSHLQGEKQ---------KATEASAVEQTAESCEVQEMLKVARAEKDLL 513
L L+ + + L+ + K E A A+ ++QE L A +
Sbjct: 1654 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 1713
Query: 514 ELSCNELRQEL---LKANGEIK--------HVSSLLAKVEKDYSYLKEICDH------QA 556
+L EL +EL L ++ ++ L ++E++ ++ + D QA
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773
Query: 557 EQLSRTSLKLQEKASESDAEIKDMKETIFELEDQV-EQHRAVKLHNNQLISELESSVIKL 615
EQLS + A ++++ + ++ EL ++ E AVK I+ LE+ + +L
Sbjct: 1774 EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1833
Query: 616 EEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQ---ELRTVKRKL 672
EEQ R+ + TK +K++ ++ + ++ +A K +A++ ++ +KR+L
Sbjct: 1834 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1893
Query: 673 LEEEEKNAR-------LQKELGD 688
E EE++ R LQ+EL +
Sbjct: 1894 EEAEEESQRINANRRKLQRELDE 1916
Score = 85.1 bits (209), Expect = 2e-16
Identities = 102/466 (21%), Positives = 201/466 (43%), Gaps = 84/466 (18%)
Query: 285 SELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETS 344
+E L L +K ++ E + E+LQA + ++ ++M L A+ ++L + +E
Sbjct: 878 AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR 937
Query: 345 FHQHRERAEQLSQENEKL---MNLLQERVKNE---------EPTTQEGKIIELEQKCTGI 392
+ +R +QL E +K+ M L+E+++ E E T E KI +LE + +
Sbjct: 938 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 997
Query: 393 LEQ-GRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNM 451
+Q + +E+ L ++++++ + EE + A + K LK ++E + LE+
Sbjct: 998 DDQNNKLSKERKL-LEERISDLTTNLAEEEEKAKNLTK-LKNKHESMISELEVRLKKEEK 1055
Query: 452 MAKTLEECRVTLEG------------------LKMENGSLKSHLQGEKQKATEASAVEQT 493
+ LE+ + LEG LKM+ + LQ + + A +
Sbjct: 1056 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1115
Query: 494 A---------ESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV-------SSL 537
A ++QE L RA ++ E +L +EL E++ L
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1175
Query: 538 LAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMK----ETIFELEDQVEQ 593
AK E++ + LK+ D E+ +A++++M+ + + EL +Q+EQ
Sbjct: 1176 RAKREQEVTVLKKALD--------------EETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 594 HRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQ----- 648
+ K + L+ + LE++ +DL +L+ L + +E + ++ +A +Q
Sbjct: 1222 FKRAK-------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274
Query: 649 -----TAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDV 689
A ND + Q E+ +V L E E K +L K++ +
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Score = 82.0 bits (201), Expect = 2e-15
Identities = 91/393 (23%), Positives = 180/393 (45%), Gaps = 49/393 (12%)
Query: 295 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 354
++ + EE + +ELQ T + + ++EL ++ +L +EK +L+ EQ
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ----------EQ 902
Query: 355 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 414
L E E + RV ++ +Q+ IL + E+ + QQL
Sbjct: 903 LQAETELYAEAEEMRV----------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 952
Query: 415 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 474
+K+ ++ L++ ++L+EE E + L+LE+ K LE+ E L M++ +
Sbjct: 953 KKMAQQ---MLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLED-----EILVMDD---Q 1000
Query: 475 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV 534
++ +++K E + T E +E K K+ E +EL L K + +
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1060
Query: 535 SSLLAKVEKDYS-YLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQ 593
L K+E D S + ++I D QA Q++ ++L +K E A + + + I + + +++
Sbjct: 1061 EKLKRKLEGDASDFHEQIADLQA-QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 594 HRAVKLHNNQLISELESSVI---KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 650
R ++ H + L +L+S K E+QK DL +L+ L +++ D +
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-----------DTLDS 1168
Query: 651 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQ 683
+++ + +QE+ TV +K L+EE ++ Q
Sbjct: 1169 TATQQELRAKREQEV-TVLKKALDEETRSHEAQ 1200
Score = 78.6 bits (192), Expect = 2e-14
Identities = 141/664 (21%), Positives = 259/664 (39%), Gaps = 99/664 (14%)
Query: 81 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEK---RTLNAEGTDALGPNVDGTSVS 137
EK E+++++L E D + N+L E K +E+ T N + N+
Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK-- 1036
Query: 138 PGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAAS--HTGDSSCP 195
E MI LE + K +K +LE+ LK KL EG AS H +
Sbjct: 1037 -NKHESMISELEVRLKKEEKSRQELEK----LKRKL---------EGDASDFHEQIADLQ 1082
Query: 196 TSITQESSFGSPTGNQMSSDIDEYKKNI--HGNALRTSGSSSSDVTKASLSPDASDFEHI 253
I + + ++ + + I NAL+ ++ D+
Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1142
Query: 254 TAETPSRPLSSTSNPFKSSKCSTAGSSPNS----------VSELSLA------SLTEKIQ 297
AE R L K+ T S+ V+ L A S ++Q
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 298 KMEENHHSTAEELQATLQEL----SDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 353
+M + H EEL L++ ++ + Q L EN L E +L Q ++ E
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG----QAKQEVE 1258
Query: 354 QLSQENEKLMNLLQERVKNEEPTTQE--GKIIELE---QKCTGILEQGRFEREKLLNIQQ 408
++ E + LQ + + E E K+ +L+ + TG+L + + KL
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1318
Query: 409 QLTCSLRKVEEENQGALEMIKRLKEENEKLN---EFLELERHNNNMMAKTLEECRVTLEG 465
L+ L+ +E Q +E +KLN + +LE N++ + EE +
Sbjct: 1319 SLSSQLQDTQELLQ---------EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK-QN 1368
Query: 466 LKMENGSLKSHLQGEKQKATE-ASAVEQTAESCE--------VQEMLKVARAEKDLLELS 516
L+ +L L K+K + AS VE E + + + + A D LE +
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1428
Query: 517 CNELRQELLKANGEIKHVSSLLAKVEKDYSYL-------KEICDHQAEQLSRTSLKLQEK 569
N L+QEL ++ + L++ +EK K I A++ R + +EK
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 570 ASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLIS---ELESSVIKLEEQKSDLERQL 626
+++ + + ++E + E+ ++ +K L+S ++ +V +LE+ K LE Q+
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548
Query: 627 KTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVK----RKLLEEEEKNARL 682
+ + Q++E L+ + D K + ++ +K R L +E+N
Sbjct: 1549 EEMKTQLEE-----------LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 683 QKEL 686
+++L
Sbjct: 1598 RRQL 1601
Score = 71.6 bits (174), Expect = 2e-12
Identities = 127/617 (20%), Positives = 252/617 (40%), Gaps = 73/617 (11%)
Query: 71 TKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPN 130
T+ + E +K + +++R+L + E N L+ +L + E + L
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQL-------EEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 131 VDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTG 190
+ + D + ALEE K FQKE+ +L ++ +EK + ++
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ---YEEKAAAYDKLEKTKNRLQQEL 1436
Query: 191 DSSCPTSITQESSFGSPTGNQMSSD-IDEYKKNIHGNAL----RTSGSSSSDVTKASLSP 245
D Q + Q D + +KNI R + TKA LS
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA-LSL 1495
Query: 246 DASDFEHITA----ETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEE 301
+ E + A E ++ L + SSK G + + + E S +L ++++M+
Sbjct: 1496 ARALEEALEAKEELERTNKMLKAEMEDLVSSK-DDVGKNVHEL-EKSKRALETQMEEMKT 1553
Query: 302 NHHSTAEELQAT----------LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRER 351
+ELQAT +Q L Q + ++L A +E+ +++ L+ H++
Sbjct: 1554 QLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQARDEQNEEKRRQLQRQLHEYETE 1611
Query: 352 AEQLSQEN-------EKLMNLLQE-------RVKNEEPTTQEGKIIELEQK-CTGILEQG 396
E ++ +KL L++ +K E ++ + ++ + K LE
Sbjct: 1612 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1671
Query: 397 RFEREKLLNIQQQ-------LTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNN 449
R R+++ ++ L L +++E+ A K+ E E+L E L
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731
Query: 450 NMMA--KTLEECRVTL--EGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKV 505
N + K E R+ E L+ E G++++ + +KAT+ A + + E + +
Sbjct: 1732 NALQDEKRRLEARIAQLEEELEEEQGNMEA-MSDRVRKATQ-QAEQLSNELATERSTAQK 1789
Query: 506 ARAEKDLLELSCNELRQELLKANGEIKH-VSSLLAKVEKDYSYLKEICDHQAEQLSRTSL 564
+ + LE ELR +L + G +K S +A +E + L+E + +A + +
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 565 KLQEKASESDAEIKDMKETIFELEDQ---VEQHRAVKLHNNQLISELESSVIKLEEQKSD 621
L++K K +KE + ++ED+ EQ++ N + +L+ + + EE+
Sbjct: 1850 SLKQKD-------KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Query: 622 LERQLKTLTKQMKEETE 638
+ + L +++ E TE
Sbjct: 1903 INANRRKLQRELDEATE 1919
Score = 65.1 bits (157), Expect = 2e-10
Identities = 62/282 (21%), Positives = 125/282 (44%), Gaps = 26/282 (9%)
Query: 414 LRKVEEENQGALEMIKRLKEENEKLNE---FLELERHNNNMMAKTLEECRVTLEGLKMEN 470
L+K +E Q A +K L++++ +L E L+ + + EE RV L K E
Sbjct: 868 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 927
Query: 471 GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 530
+ ++ ++ + Q Q+ML + E+ L E + +L K E
Sbjct: 928 EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL---EEQLEEEEAARQKLQLEKVTAE 984
Query: 531 IKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQ 590
K + K+E + + D Q +LS+ L+E+ I D+ + E E++
Sbjct: 985 AK-----IKKLEDEIL----VMDDQNNKLSKERKLLEER-------ISDLTTNLAEEEEK 1028
Query: 591 VEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 650
+ +K + +ISELE + K E+ + +LE+ L ++++ + ++ ADLQ
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEK----LKRKLEGDASDFHEQIADLQAQ 1084
Query: 651 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGH 692
+ + ++EL+ +L +E + K++ +++GH
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1126
Score = 52.8 bits (125), Expect = 1e-06
Identities = 84/434 (19%), Positives = 186/434 (42%), Gaps = 41/434 (9%)
Query: 72 KPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNV 131
K + E+ K + V EL +A ++++ ++++L++ +++ + L N+
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1576
Query: 132 DGTSVSPGDTEPMIRALEEKNKNFQKEL--------SDLEEENRVLKEKLIYLEHSPNSE 183
G E ++A +E+N+ +++L ++LE+E K++ + E
Sbjct: 1577 QALK---GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER---KQRALAAAAKKKLE 1630
Query: 184 GAASHTGDSSCPTSITQESSFGSPTGNQMS-SDIDEYKKNIHGNALRTSGSSSSDVTKA- 241
G + +E + Q D ++ + ++ + KA
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690
Query: 242 SLSPDASDF-EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME 300
SL D E + A +R + + + +++ S N++ + L +I ++E
Sbjct: 1691 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD-EKRRLEARIAQLE 1749
Query: 301 ENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENE 360
E EE Q ++ +SD+ V++ T + E+L +E ++ ++ +QL ++N+
Sbjct: 1750 EE----LEEEQGNMEAMSDR---VRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1802
Query: 361 KLMNLLQER---VKNEEPTT---QEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 414
+L + L E VK++ +T E KI +LE++ + + + L ++L L
Sbjct: 1803 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862
Query: 415 RKVEEENQGALEM----------IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLE 464
+VE+E + A + +K+LK + E+ E + N + + L+E + E
Sbjct: 1863 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Query: 465 GLKMENGSLKSHLQ 478
+ E +LKS L+
Sbjct: 1923 AMGREVNALKSKLR 1936
Score = 52.4 bits (124), Expect = 1e-06
Identities = 111/597 (18%), Positives = 238/597 (39%), Gaps = 65/597 (10%)
Query: 28 REFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALES 87
++F+ TV ++ G +K + + T + + TK + + E +
Sbjct: 1388 QDFASTVE---ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444
Query: 88 QVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRA 147
R+L++ + K + ++L +E K K + +A + ++S + RA
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS------LARA 1498
Query: 148 LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSP 207
LEE + KE +LE N++LK ++ L S + G H + S TQ +
Sbjct: 1499 LEEALE--AKE--ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 208 TGNQMSSDI---DEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSS 264
++ ++ ++ K + N G D+ A D ++ E R L
Sbjct: 1555 L-EELEDELQATEDAKLRLEVNMQALKGQFERDL-------QARDEQN---EEKRRQLQR 1603
Query: 265 TSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMV 324
+ +++ +++ + L ++ +E S + + +++L Q +
Sbjct: 1604 QLHEYETELEDER--KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1661
Query: 325 QELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQ--ERVKNEEPTTQEGKI 382
++ E E + + + ++ ++A+ L + +L L ER + + +E
Sbjct: 1662 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 383 IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEE---NQGALEM----IKRLKEEN 435
EL +G R L + +++L + ++EEE QG +E +++ ++
Sbjct: 1722 EELASSLSG--------RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773
Query: 436 EKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAE 495
E+L+ L ER A+ E R LE E S ++G + +++ A+
Sbjct: 1774 EQLSNELATERST----AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829
Query: 496 SCEVQEMLKVARAEKDLLELSCNE----LRQELLKANGEIKHVSSLLAKVEKDYSYLKEI 551
+++E ++ EK S + L++ LL+ E K + EK + +K
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK-- 1887
Query: 552 CDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISEL 608
QL R + +E++ +A + ++ EL++ E + A+ N L S+L
Sbjct: 1888 ------QLKRQLEEAEEESQRINANRRKLQR---ELDEATESNEAMGREVNALKSKL 1935
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 87.8 bits (216), Expect = 3e-17
Identities = 142/747 (19%), Positives = 301/747 (40%), Gaps = 138/747 (18%)
Query: 74 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKY---------------KEKRT 118
KQ+N+ + LE++ LL++ KD E+ L+ E+ K K K T
Sbjct: 1856 KQKNKEFSQT-LENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKET 1914
Query: 119 LNAEGTDA----------LGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEE-NR 167
E D L ++ D + LE + KN +K +S+LEEE +
Sbjct: 1915 AEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQ 1974
Query: 168 VLKEKL-----IYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKN 222
++KEK I E+ +GA G+ S + + Q+ D Y++
Sbjct: 1975 LVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEK 2034
Query: 223 IHG--------NALRTSGSSSSDVTKASLS----------PDASDFEHITAETPSRPLSS 264
I ++T ++TK +L+ + + F+ + +T S
Sbjct: 2035 ISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARV 2094
Query: 265 TSNPFKSSK-CSTAGSSPNSVSELSLASLTEKIQKMEENH-------------------- 303
++ K K + S S + L ++++ EE H
Sbjct: 2095 LADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVH 2154
Query: 304 -HSTAEELQATLQELSDQQQMVQE------------------LTAENEKLVDEKTILETS 344
T E+Q TL + + Q +QE L + ++++DE E
Sbjct: 2155 LEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERK 2214
Query: 345 FHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLL 404
F + E+ + E ++L+++++ +E KI + + + + + E +
Sbjct: 2215 FSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTE--V 2272
Query: 405 NIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNM------MAKTLEE 458
+QQ++ +L+ +E LE + L ++ NE +LE ++ ++ +LE+
Sbjct: 2273 QLQQKVCDTLQGENKELLSQLEETRHLYHSSQ--NELAKLESELKSLKDQLTDLSNSLEK 2330
Query: 459 CRV---TLEG-LKMENGSLKSHLQGEKQKATEASAVEQTAE------SCEVQEMLKVARA 508
C+ LEG ++ + +++ +Q T+ A + + + Q+++ +
Sbjct: 2331 CKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSG 2390
Query: 509 EKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKE---ICDHQAEQLSRTSLK 565
+++ ++++ ELRQ+ K EIK + +LL++ E++ L+E + QL T
Sbjct: 2391 KEEAIQVAIAELRQQHDK---EIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKT 2447
Query: 566 LQEKASESDAEIKDMKETIFELEDQ-----------VEQHRAVKLHNNQLISELESSVIK 614
++++ + A++ +++ L++ E+H ++ L +QLI E + K
Sbjct: 2448 IKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNK 2507
Query: 615 LEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVAN-------DIKCEAQQELRT 667
L+E+ L + L + + E +++ DL + + + +++ + +EL
Sbjct: 2508 LKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELEN 2567
Query: 668 ----VKRKLLEEEEKNARLQKELGDVQ 690
++ KL E EE N L++ +Q
Sbjct: 2568 KYAKLEEKLKESEEANEDLRRSFNALQ 2594
Score = 79.0 bits (193), Expect = 1e-14
Identities = 140/675 (20%), Positives = 267/675 (39%), Gaps = 122/675 (18%)
Query: 81 EKAALESQVRELLAEAKA----KDSEINRLRSELKK----YKEKRTLNAEGTDA------ 126
EK A E Q + L+ + K ++I+ L++E+ + ++ T N + +D
Sbjct: 1082 EKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALV 1141
Query: 127 -----LGPNVDGTSVS-PGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSP 180
+ P G+S + E I ALE++ + QK+L + + + +K E
Sbjct: 1142 KETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHL 1201
Query: 181 NSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTK 240
E + ++S G+Q+ + +++I G T S T
Sbjct: 1202 REELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTP 1261
Query: 241 ASLSP--DASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSEL----SLASLTE 294
P A++ H T +S+ C S S L S+A +
Sbjct: 1262 GLEEPLFKATEQHH------------TQPVLESNLCPDWPSHSEDASALQGGTSVAQIKA 1309
Query: 295 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 354
+++++E ++ +T EL+ + + V +L + K E L+T H+ AE
Sbjct: 1310 QLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAES 1369
Query: 355 LSQ--ENEKLMNLLQERVKNEEPTTQE-GKIIELEQKCTGILEQGRFEREKLLNIQQQLT 411
L Q E+ +L E ++ +P E K+I +++ L E+E
Sbjct: 1370 LQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKE---------- 1419
Query: 412 CSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKM-EN 470
+L K++ E ++IK L + E ++ + H+ + +E C + + ++ E
Sbjct: 1420 AALTKIQTEIIEQEDLIKALHTQLE-----MQAKEHDERIKQLQVELCEMKQKPEEIGEE 1474
Query: 471 GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 530
K +Q K +A S E E+ +QE L +AR + L S ++ ++ N E
Sbjct: 1475 SRAKQQIQ-RKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKE 1533
Query: 531 IKHVSSLLAKVEKDYSYL-----KEICDHQAEQLSRTSLKL------------------- 566
V LA ++++ L + + ++Q+ S SLKL
Sbjct: 1534 KDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL 1593
Query: 567 -----------QEKASESDAEIKDMKETIFELEDQVE--QH--RAVKLHNNQLISELESS 611
QEK E E + + ++ + ++ E QH AV+ +L +L S+
Sbjct: 1594 KSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRST 1653
Query: 612 VIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRK 671
E K + E+QL+ ++M+E E+ R+F ++ ++K
Sbjct: 1654 ----EANKKETEKQLQEAEQEMEEMKEKMRKF---------------------AKSKQQK 1688
Query: 672 LLEEEEKNARLQKEL 686
+LE EE+N RL+ E+
Sbjct: 1689 ILELEEENDRLRAEV 1703
Score = 78.6 bits (192), Expect = 2e-14
Identities = 102/434 (23%), Positives = 184/434 (42%), Gaps = 44/434 (10%)
Query: 286 ELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSF 345
+L+L LTE +K+ + S + + E ++ Q+ +EL E E L+ +
Sbjct: 1573 KLALEGLTEDKEKLVKEIESLKS---SKIAESTEWQEKHKELQKEYEILLQSYENVSNEA 1629
Query: 346 HQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGR----FERE 401
+ + E + QE ++L L+ N++ T E ++ E EQ+ + E+ R +++
Sbjct: 1630 ERIQHVVEAVRQEKQELYGKLRSTEANKKET--EKQLQEAEQEMEEMKEKMRKFAKSKQQ 1687
Query: 402 KLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRV 461
K+L ++++ +V A E ++ L N + E LE + ++K +
Sbjct: 1688 KILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMS 1747
Query: 462 TLEGLKMENGSLKSHLQGEKQKATEASAVE----QTAESCEVQEMLKVARAEKDLLELSC 517
+ L E LK ++G K A E QT + E + + E+D L +S
Sbjct: 1748 EKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMST 1807
Query: 518 NELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDH--QAEQLSRTSLKLQE---KASE 572
E + S V KD+S EI ++ Q +QL L+E K E
Sbjct: 1808 RPTCSE------SVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKE 1861
Query: 573 SDAEIKDMKETIF--------ELEDQVEQHRAVKLHNNQLISELESSVIKL----EEQKS 620
+++ K T+ EL+ E+ + L N Q+ EL S V KL EE+K
Sbjct: 1862 FSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEEL-SRVTKLKETAEEEKD 1920
Query: 621 DLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNA 680
DLE +L ++ + + D Q + N++ + E++ +K+ + E EE+
Sbjct: 1921 DLEERLMNQLAELNGSIGNYCQDVTDAQ----IKNEL---LESEMKNLKKCVSELEEEKQ 1973
Query: 681 RLQKELGDVQGHGR 694
+L KE V+ R
Sbjct: 1974 QLVKEKTKVESEIR 1987
Score = 67.8 bits (164), Expect = 3e-11
Identities = 103/463 (22%), Positives = 180/463 (38%), Gaps = 105/463 (22%)
Query: 295 KIQKMEENHHSTAEELQATLQELSD-----------QQQMVQELTAENEKLVDE------ 337
K++ E N T ++LQ QE+ + +QQ + EL EN++L E
Sbjct: 1649 KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD 1708
Query: 338 --KTILETSFHQH---RERAEQLSQENEKLMNLLQERVKNEEPTTQEGKII--------- 383
K +ET + +E E++ E E L Q + ++ ++E + +
Sbjct: 1709 TAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVS 1768
Query: 384 --------ELEQKCTGILEQG------RFEREKLLNIQQQLTCSLR-------------- 415
E T + E+G E + L++ + TCS
Sbjct: 1769 KQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKD 1828
Query: 416 -KVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLE-ECRVTLEGLKMENGSL 473
+E L+ I +LKE L E E+ N ++TLE E L + ++G L
Sbjct: 1829 FSSHDEINNYLQQIDQLKERIAGLEE----EKQKNKEFSQTLENEKNTLLSQISTKDGEL 1884
Query: 474 KSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKH 533
K LQ E K + Q E V ++ + A EKD LE L +L + NG I +
Sbjct: 1885 KM-LQEEVTKMNLLNQQIQE-ELSRVTKLKETAEEEKDDLE---ERLMNQLAELNGSIGN 1939
Query: 534 VSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQ 593
Y +++ D Q K ++E+K++K+ + ELE++ +Q
Sbjct: 1940 -------------YCQDVTDAQI------------KNELLESEMKNLKKCVSELEEEKQQ 1974
Query: 594 HRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQAD------- 646
K I + I+ +++ + K L + +KE+ +E ++ Q D
Sbjct: 1975 LVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEK 2034
Query: 647 ---LQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKEL 686
L+ V ++ E+Q++L K L + E + Q EL
Sbjct: 2035 ISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAEL 2077
Score = 64.3 bits (155), Expect = 4e-10
Identities = 134/654 (20%), Positives = 262/654 (40%), Gaps = 70/654 (10%)
Query: 81 EKAALESQ-VRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPG 139
E+A +Q +++L + + K EI++ + L + + D +GT
Sbjct: 411 EQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYN---EGTQAV-- 465
Query: 140 DTEPMIRALEEKNKNFQKE----------LSDLEEENRVLKEKLIYLEHSPNSEGAASHT 189
TE I +L+++ + E L +L+ EN L ++ LE + A
Sbjct: 466 -TEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREV 524
Query: 190 GDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLS----- 244
+ S + SS +G + + K L + ++ L
Sbjct: 525 SEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKR 584
Query: 245 PDASDFEHITAETPSRPLSSTSNPFKSSKC--STAGSSPNSVSELSLASLTEKIQKMEEN 302
+ +D E + + + P K T P +E S EK Q E+
Sbjct: 585 AEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEH 644
Query: 303 HHSTAEELQ---ATLQELSDQQQMVQELTA----------ENEKLVDEKTILETSFHQHR 349
T+EE+ A ++ S +Q + L+A E E+L + LE +FH+ +
Sbjct: 645 QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQ 704
Query: 350 E----RAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLN 405
E ++ ++E L L++E KN + L ++ +L Q K L+
Sbjct: 705 EIYEKNLDEKAKEISNLNQLIEEFKKNAD--NNSSAFTALSEERDQLLSQ-----VKELS 757
Query: 406 IQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELER-HNNNMMAKTLEECRVTLE 464
+ +L ++++ E N E +RL E++ ++ L E+ H+ ++ AK+ + V +E
Sbjct: 758 MVTELRAQVKQL-EMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKD---VKIE 813
Query: 465 GLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQEL 524
L+ E ++ + + Q ES EV E + R +E EL Q L
Sbjct: 814 VLQNELDDVQLQFSEQSTLIRSLQSQLQNKES-EVLEGAERVRHISSKVE----ELSQAL 868
Query: 525 LKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESD-------AEI 577
+ EI + LL + ++D L++ + + +Q++ S + EK + + EI
Sbjct: 869 SQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEI 928
Query: 578 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 637
K +KE + L E + +N++ S L+ + ++ + +L+ +K+E
Sbjct: 929 KTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKEN 988
Query: 638 EEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARL-QKELGDVQ 690
E+ +R LQ A++ ++ + L L +E +K L + E G+V+
Sbjct: 989 EQRKR---KLQAALINRKEL-LQRVSRLEEELANLKDESKKEIPLSETERGEVE 1038
Score = 63.2 bits (152), Expect = 8e-10
Identities = 88/436 (20%), Positives = 182/436 (41%), Gaps = 47/436 (10%)
Query: 292 LTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRER 351
LTE+I + S +++ EL D Q E + L + E+ + ER
Sbjct: 794 LTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAER 853
Query: 352 AEQLSQENEKLMNLLQER----VKNEEPTTQEGKIIE-----LEQKCTGILEQGRFEREK 402
+S + E+L L ++ K ++ ++ + +E +E+K + E EK
Sbjct: 854 VRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEK 913
Query: 403 LLNIQQQ---LTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAK----T 455
++ + ++ L ++ ++E+ + KE+ E+ NE + N + M+ +
Sbjct: 914 MVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQIS 973
Query: 456 LEECRVTLEGLKMENGSLKSHLQG----EKQKATEASAVEQTAESCEVQEMLKVARAEKD 511
EE + + LK EN K LQ K+ S +E+ E+ + ++ E
Sbjct: 974 KEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEE-----ELANLKDESKKEIP 1028
Query: 512 LLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKAS 571
L E E+ ++ K V+S ++E YLK+ + +L L+EK +
Sbjct: 1029 LSETERGEVEEDKENKEYSEKCVTSKCQEIE---IYLKQTISEKEVELQHIRKDLEEKLA 1085
Query: 572 ESD---AEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKS-DLERQLK 627
+ A +K M +T+ + +Q++ +A N +I +L +S + S L ++
Sbjct: 1086 AEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETV 1145
Query: 628 TLTKQMKEETEEWR---------------RFQADLQTAVVVANDIKCEAQQELRTVKRKL 672
++ +E W+ + Q LQ A+ I +AQ++ R ++ +L
Sbjct: 1146 VISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREEL 1205
Query: 673 LEEEEKNARLQKELGD 688
++++ RLQ++ +
Sbjct: 1206 KQQKDDYNRLQEQFDE 1221
Score = 59.7 bits (143), Expect = 9e-09
Identities = 113/598 (18%), Positives = 238/598 (39%), Gaps = 75/598 (12%)
Query: 101 SEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKN----KNFQ 156
SE R+ ++ K K++ N E + D D E + EEK+ KN Q
Sbjct: 2089 SEAARVLADNLKLKKELQSNKESVKSQMKQKDE------DLERRLEQAEEKHLKEKKNMQ 2142
Query: 157 KELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDI 216
++L L E L+E + ++ + N + + +++TQ ++F + S +
Sbjct: 2143 EKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAF-----TKSMSSL 2197
Query: 217 DEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCST 276
+ + + A + S + S E I K CS
Sbjct: 2198 QDDRDRVIDEAKKWERKFSDAIQ--------SKEEEIR--------------LKEDNCSV 2235
Query: 277 AGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVD 336
+S + + L I ++E + + Q +Q QQ++ L EN++L+
Sbjct: 2236 LKDQLRQMS-IHMEELKINISRLEHDKQIWESKAQTEVQL---QQKVCDTLQGENKELLS 2291
Query: 337 EKTILETSFHQHRERAEQLSQENEKLMNLLQERVKN-EEPTTQEGKIIELEQKCTGILEQ 395
+ +H + +L E + L + L + + E+ Q+G + + ++ ++
Sbjct: 2292 QLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQN 2351
Query: 396 GRFEREKL---LNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMM 452
+F E+L L ++LT L EE N ++I L + E + + R ++
Sbjct: 2352 SKFSYEQLETDLQASRELTSRLH--EEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKE 2409
Query: 453 AKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDL 512
K LE L + EN L+ + K + +T + +Q+ +A+ D
Sbjct: 2410 IKELENL---LSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQ-----KAQLDS 2461
Query: 513 LELSCNELRQELLKANG-----EIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQ 567
S + L+ + + G E +H+S +L K D ++ + + KL+
Sbjct: 2462 FVKSMSSLQNDRDRIVGDYQQLEERHLSIILEK------------DQLIQEAAAENNKLK 2509
Query: 568 EKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLK 627
E+ + + D+ +L+ ++ Q+R NQ+I+ +S +L E + ++L+
Sbjct: 2510 EEIRGLRSHMDDLNSENAKLDAELIQYRE---DLNQVITIKDSQQKQLLEVQLQQNKELE 2566
Query: 628 TLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKE 685
+++E+ +E DL+ + + K + +E+ ++K + + + LQ+E
Sbjct: 2567 NKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEE 2624
Score = 58.5 bits (140), Expect = 2e-08
Identities = 128/609 (21%), Positives = 242/609 (39%), Gaps = 97/609 (15%)
Query: 74 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 133
K E E+ A ++++++L AKAK + +N+ E+K G
Sbjct: 78 KDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMK-------------------AQG 118
Query: 134 TSVSPGDTEPMIRA-LEEKNKNFQKELSDLEEENRVLKEK--LIYLEHSPNSEGAASHTG 190
+V P TEP L + +K+ +E ++E+ L+EK LI + ++ A
Sbjct: 119 GTVLP--TEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPA 176
Query: 191 DSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDF 250
SS T+ F M + E ++ I + S + + + + + F
Sbjct: 177 QSS-----TEMEEFV-----MMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARF 226
Query: 251 EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEEL 310
E L + + + + L L K+++ EE+ A+ +
Sbjct: 227 ETQVRLHEDELLQLVTQ-----------ADVETEMQQKLRVLQRKLEEHEESLVGRAQVV 275
Query: 311 QATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENE--------KL 362
QEL+ +Q Q L+ + +++ E L + RE ++ L ++ E
Sbjct: 276 DLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSF 335
Query: 363 MNLLQERVKNEEPTTQEGKI-IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEEN 421
NL +E E Q G+ ELE + + + ++ + E E+ + SL+K +E
Sbjct: 336 HNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEE----KTSHILSLQKTGQEL 391
Query: 422 QGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEK 481
Q A + LK++N KL L+ + A+T+++ L+ E + L ++
Sbjct: 392 QSACDA---LKDQNSKL---LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQ 445
Query: 482 QK-ATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAK 540
+ A++ S + E + +A +K ++EL NE + LL ++ E++ L A+
Sbjct: 446 HETASQTSFPDVYNEGTQAVTEENIASLQKRVVELE-NE-KGALLLSSIELEE---LKAE 500
Query: 541 VEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLH 600
EK S + T L+ Q + E+D E+ ++ V +
Sbjct: 501 NEKLSSQI-------------TLLEAQNRTGEADREVSEIS--------------IVDIA 533
Query: 601 NNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCE 660
N + S ES LE S ++L L +MKE EE + LQ D +
Sbjct: 534 NKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVL 593
Query: 661 AQQELRTVK 669
Q+E++ ++
Sbjct: 594 DQKEMKQME 602
Score = 56.6 bits (135), Expect = 8e-08
Identities = 92/475 (19%), Positives = 200/475 (42%), Gaps = 57/475 (12%)
Query: 225 GNALRTSGSSSSDVTK--ASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPN 282
G L T S ++K S + + + E I + + ++ + ++ + +
Sbjct: 119 GTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQS 178
Query: 283 SVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILE 342
S + +++Q+ EE LQA L + +Q Q + ++ + + + E
Sbjct: 179 STEMEEFVMMKQQLQEKEE----FISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHE 234
Query: 343 TSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREK 402
Q +A+ ++ +KL L ++ ++EE ++++L
Sbjct: 235 DELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDL----------------- 277
Query: 403 LLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLE----E 458
+QQ+LT + E+ NQ + +++++ E+ L +E ER + ++ + +E E
Sbjct: 278 ---LQQELTAA----EQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAE 330
Query: 459 CRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCN 518
+++ L+ E HL + ++A +A A E + +++ K EK LS
Sbjct: 331 RKLSFHNLQEE----MHHLLEQFEQAGQAQA-ELESRYSALEQKHKAEMEEKTSHILSLQ 385
Query: 519 ELRQELLKANGEIKHVSSLLAKVEKDYS--------YLKEICDHQAEQLSR--TSLKLQE 568
+ QEL A +K +S L + + + + L++ +++++S+ L LQ+
Sbjct: 386 KTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQ 445
Query: 569 KASESDAEIKDM----KETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLER 624
+ S D+ + + E Q R V+L N + L S I+LEE K++ E+
Sbjct: 446 HETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEK--GALLLSSIELEELKAENEK 503
Query: 625 QLKTLT-KQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEK 678
+T + + T E R +++ + V +AN A++ + V ++ K
Sbjct: 504 LSSQITLLEAQNRTGEADREVSEI-SIVDIANKRSSSAEESGQDVLENTFSQKHK 557
Score = 54.3 bits (129), Expect = 4e-07
Identities = 129/670 (19%), Positives = 262/670 (39%), Gaps = 96/670 (14%)
Query: 81 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDA----LGPNVDGTSV 136
E+ L SQV+EL + + +++ +L L + + +R L+ E A L + S+
Sbjct: 745 ERDQLLSQVKELSMVTELR-AQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSI 803
Query: 137 SPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPT 196
+ I L+ + + Q + S+ R L+ +L E S EGA SS
Sbjct: 804 EAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKE-SEVLEGAERVRHISSKVE 862
Query: 197 SITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFE----- 251
++Q S +M + E K+++ +T VT+ S S +
Sbjct: 863 ELSQALSQKELEITKMDQLLLEKKRDVE-TLQQTIEEKDQQVTEISFSMTEKMVQLNEEK 921
Query: 252 ---HITAETPSRPLSSTSNPFKSSKCS-------TAGSSPN-----SVSELSLASLTEKI 296
+ +T L+ S ++ K ++G N ++S L +
Sbjct: 922 FSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEF 981
Query: 297 QKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLS 356
+++ + +LQA L + Q V L E L DE R E+
Sbjct: 982 DLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEE-D 1040
Query: 357 QENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRK 416
+EN++ +E+ T + + IE+ K T EK + +Q +RK
Sbjct: 1041 KENKEY---------SEKCVTSKCQEIEIYLKQT--------ISEKEVELQH-----IRK 1078
Query: 417 VEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSH 476
EE A E + L ++ +N+ L+ + + +++ + E + ++ L N
Sbjct: 1079 DLEEKLAAEEQFQALVKQ---MNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDG 1135
Query: 477 LQGEKQKATEASAVEQTAES----CEVQEMLKVARAEKDLLELSCNEL----RQELLKAN 528
K T + T S E++E + EK+ L+ E + L KA
Sbjct: 1136 DSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQ 1195
Query: 529 GEIKHVSSLLAKVEKDYSYLKEICDHQA-------EQLSRTSLKLQEK---------ASE 572
+ +H+ L + + DY+ L+E D Q+ +QL + ++++E E
Sbjct: 1196 EKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQE 1255
Query: 573 SDAEIKDMKETIFELEDQ----------------VEQHRAVKLHNNQLISELESSVIKLE 616
S + ++E +F+ +Q A L ++++++ + ++E
Sbjct: 1256 SCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIE 1315
Query: 617 EQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKC---EAQQELRTVKRKLL 673
+K +LE ++ + T ++ +++EE + Q + + +K EA+ ++++KL
Sbjct: 1316 AEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLE 1375
Query: 674 EEEEKNARLQ 683
+ + A L+
Sbjct: 1376 SSQLQIAGLE 1385
Score = 53.1 bits (126), Expect = 9e-07
Identities = 87/438 (19%), Positives = 179/438 (40%), Gaps = 77/438 (17%)
Query: 316 ELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEP 375
+L+ + ++E+ A+ ++ + E +H + + + E EK+ + LQE K E
Sbjct: 103 KLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQE--KEELI 160
Query: 376 TTQEGKI--IELEQKCTGILEQGRF--------EREKLLNI------QQQLTCSLRKVEE 419
+T + ++ + EQ E F E+E+ ++ Q Q + ++V
Sbjct: 161 STLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVR 220
Query: 420 ENQGALEMIKRLKEE---------------NEKLNEF-LELERHNNNMM--AKTLEECRV 461
E E RL E+ +KL +LE H +++ A+ ++ +
Sbjct: 221 EKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQ 280
Query: 462 TLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLE--LSCNE 519
L + N L LQ Q E + + T E+ + + + + E ++ E LS +
Sbjct: 281 ELTAAEQRNQILSQQLQ---QMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHN 337
Query: 520 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTS--LKLQEKASESDAEI 577
L++E+ + + A++E YS L++ H+AE +TS L LQ+ E +
Sbjct: 338 LQEEMHHLLEQFEQAGQAQAELESRYSALEQ--KHKAEMEEKTSHILSLQKTGQELQSAC 395
Query: 578 KDMK------------------ETIFELEDQVEQH--------RAVKLHNNQLISELESS 611
+K +TI +LEDQ++Q + L ++ S+
Sbjct: 396 DALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFP 455
Query: 612 VIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRK 671
+ E ++ E + +L K++ E E + L + + ++K A+ E + +
Sbjct: 456 DVYNEGTQAVTEENIASLQKRVVELENE----KGALLLSSIELEELK--AENEKLSSQIT 509
Query: 672 LLEEEEKNARLQKELGDV 689
LLE + + +E+ ++
Sbjct: 510 LLEAQNRTGEADREVSEI 527
Score = 50.1 bits (118), Expect = 7e-06
Identities = 125/643 (19%), Positives = 244/643 (37%), Gaps = 108/643 (16%)
Query: 81 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 140
+K LE +R+ A+ + +L ++L+ +E + E + + S+ G
Sbjct: 2334 QKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKI--ISLLSGK 2391
Query: 141 TEPMIRALEEKNKNFQKELSDLE-------EENRVLKEKLIYLEHSPNSEGAASHTGDSS 193
E + A+ E + KE+ +LE EEN VL+E+ + + + T +
Sbjct: 2392 EEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEEN---KKAVDKTNQLMETLKTI 2448
Query: 194 CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI 253
+I Q++ S + S D + I G+ + S + + + E+
Sbjct: 2449 KKENIQQKAQLDSFVKSMSSLQND--RDRIVGDYQQLEERHLSIILEKDQLIQEAAAENN 2506
Query: 254 TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEEL-QA 312
+ R L S + S N+ + L E + ++ S ++L +
Sbjct: 2507 KLKEEIRGLRSHMDDLNSE---------NAKLDAELIQYREDLNQVITIKDSQQKQLLEV 2557
Query: 313 TLQ---ELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQER 369
LQ EL ++ ++E E+E+ ++ L SF+ +E + LS+E E L
Sbjct: 2558 QLQQNKELENKYAKLEEKLKESEEANED---LRRSFNALQEEKQDLSKEIESL------- 2607
Query: 370 VKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIK 429
+ I +L ++ T + E+G T L +
Sbjct: 2608 ---------KVSISQLTRQVTALQEEG--------------TLGLYHAQ----------- 2633
Query: 430 RLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGE-KQKATEAS 488
LK + E+++ L + +A+ EE + + G ++ L+ E K +A
Sbjct: 2634 -LKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAG 2692
Query: 489 AVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYL 548
+ E+ E +VA +DL+ E+ Q+LL E K +++ + + S L
Sbjct: 2693 IMRNETETAEE----RVAELARDLV-----EMEQKLLMVTKENKGLTAQIQSFGRSMSSL 2743
Query: 549 KEICDHQAEQLSRTSLKLQEKASESDAEIKD-----------MKETIFELEDQVEQHRAV 597
+ DH E+L K E A++K+ + ET F + E +
Sbjct: 2744 QNSRDHANEELDELKRKYDASLKEL-AQLKEQGLLNRERDALLSETAFSMNSTEENSLSH 2802
Query: 598 KLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK----------EETEEWRRFQADL 647
NQ + + ++ L Q D Q+++ +K M E E++R+ +
Sbjct: 2803 LEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGK 2862
Query: 648 QTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 690
Q + + E Q ++K+ + + RL KEL ++Q
Sbjct: 2863 QRSAAQPSTSPAEVQ----SLKKAMSSLQNDRDRLLKELKNLQ 2901
Score = 44.3 bits (103), Expect = 4e-04
Identities = 57/230 (24%), Positives = 99/230 (43%), Gaps = 36/230 (15%)
Query: 480 EKQKATEASAVEQTAESCEVQEMLKVARAEKDL-LELSCNELRQELLKANGEIK----HV 534
E T+ E+ A + ++ LK +KD+ L+ L++E A+ +IK H
Sbjct: 41 EFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHA 100
Query: 535 SSLLAKVEKDYSYLKEICDH-----QAEQLSRTSLKLQEKAS-ESDAEIKDMKETIFELE 588
+ L + K Y++E+ E S L +K+S E + EI+ +K + E E
Sbjct: 101 KAKLTSLNK---YIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKE 157
Query: 589 D-----QVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWR-- 641
+ Q + +A Q +E+E V+ +++Q + E + TL Q+ + E
Sbjct: 158 ELISTLQAQLTQAQAEQPAQSSTEMEEFVM-MKQQLQEKEEFISTLQAQLSQTQAEQAAQ 216
Query: 642 --------------RFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEE 677
R D +V D++ E QQ+LR ++RKL E EE
Sbjct: 217 QVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEE 266
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 85.9 bits (211), Expect = 1e-16
Identities = 143/640 (22%), Positives = 273/640 (42%), Gaps = 108/640 (16%)
Query: 90 RELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALE 149
R+ L + K +++L SE+ +YKE R + E A + + +T+ M+
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKE-RLHDIEFYKARVEELKEDNQVLLETKTMLEDQL 367
Query: 150 EKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTG 209
E + +L +LE+EN LK KL +E
Sbjct: 368 EGTRARSDKLHELEKENLQLKAKLHDME-------------------------------- 395
Query: 210 NQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPF 269
M D+D K L + K S+ D S E SR + P
Sbjct: 396 --MERDMDRKKIE----ELMEENMTLEMAQKQSM--DESLHLGWELEQISRTSELSEAPQ 447
Query: 270 KSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTA 329
KS + V+EL+ + L K++ ++ T EEL+ T+ + + ++
Sbjct: 448 KSLG--------HEVNELTSSRLL-KLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498
Query: 330 ENEKLVDEKTILETSFHQHR---ERAEQLSQENEKLMNLLQERVKN-EEPTTQEGKIIE- 384
EN++L + ILE Q + + + LS++ K L++ ++ E + ++ KI+E
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558
Query: 385 ----LEQKCTGILEQGRFERE----------KLLNIQQQLTCS-LRKVEEENQGALEMIK 429
L Q + + ++ + E K+L+ + T S L K+E E + + ++
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 430 RLKEENEKLNEFLELERHN----NNMMAKTLEECRVTLE----------GLKMENGSLKS 475
KE+ E+ E LE E H+ N ++ K + ++T E L+ EN LK
Sbjct: 619 HYKEKGERAEE-LENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677
Query: 476 HLQGEKQKATEASAVEQ-----TAESCEVQ---EMLKVARAEKDLLELSCNELRQELLKA 527
L K + ++E+ E+ E++ E LK A + L+L EL E +
Sbjct: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737
Query: 528 NGEIKHVSSLLAKVEK-DYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFE 586
++ + + K E+ + SY + D + ++L +T +K + ++E++D+ E
Sbjct: 738 KKGLELLKASFKKTERLEVSY--QGLDIENQRLQKTLENSNKKIQQLESELQDL-----E 790
Query: 587 LEDQVEQHRAVKLH-NNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQA 645
+E+Q Q +L +++ + +LE LE++ S LE+ K L K+ K R QA
Sbjct: 791 MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR-----LRQQA 845
Query: 646 DLQTAVVVANDIKC-EAQQELRTVKRKLLEEEEKNARLQK 684
+++ + N++K ++E +T+ +++ +E RL++
Sbjct: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
Score = 83.6 bits (205), Expect = 6e-16
Identities = 131/573 (22%), Positives = 238/573 (41%), Gaps = 86/573 (15%)
Query: 140 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSIT 199
++E I+ LE++N++ + +S L + +++ E + N S SS + I
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607
Query: 200 QESSFGSPTGNQMSSDIDEYKKN----------IHG----NALRTSGSSSSDVTKASLSP 245
E Q+ +++ YK+ +H N L ++ +T +
Sbjct: 608 FEK-------RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKI-- 658
Query: 246 DASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENH-- 303
+A + E+ E +R L T + FK+ L SL ++ +++E +
Sbjct: 659 EALEQENSELERENRKLKKTLDSFKNLT-------------FQLESLEKENSQLDEENLE 705
Query: 304 -HSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQ----E 358
E L+ +++ Q +EL +E E+L +L+ SF + ER E Q E
Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKK-TERLEVSYQGLDIE 764
Query: 359 NEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVE 418
N++L L+ K + E + +E+E + Q E K+ + + L ++E
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQDLEMENQTL----QKNLEELKISSKR------LEQLE 814
Query: 419 EENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQ 478
+EN+ + +L+++ ++L + + R + TLEE V + L+ EN +L +
Sbjct: 815 KENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIG 874
Query: 479 GEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLL 538
K+ +E+ E +E++K A + L +L E LK + L
Sbjct: 875 IYKESCVRLKELEK-----ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLT 929
Query: 539 AKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASES----DAEIKDMKETIFELEDQVEQH 594
++EK KE H + + KL E ES EIK+ E I LE ++E+
Sbjct: 930 HELEK-IGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKE--EKIAALEARLEES 986
Query: 595 RAVKLHNNQLISELESSVIKLE--EQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVV 652
+N QL EL++ E +Q+ D ER +++ + + E +W R
Sbjct: 987 TN---YNQQLRQELKTVKKNYEALKQRQDEERMVQS-SPPISGEDNKWERESQ------- 1035
Query: 653 VANDIKCEAQQELRTVKRKLLEEEEKNARLQKE 685
E +EL VK +L+E E NA LQ E
Sbjct: 1036 -------ETTRELLKVKDRLIEVERNNATLQAE 1061
Score = 81.3 bits (199), Expect = 3e-15
Identities = 140/628 (22%), Positives = 254/628 (40%), Gaps = 91/628 (14%)
Query: 81 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 140
E L ++E ++ + E +++ EL+ YKEK E + L +
Sbjct: 588 ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK----GERAEELENELHHLEKENEL 643
Query: 141 TEPMIRALE---EKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTS 197
+ I L+ EK + ++E S+LE ENR LK+ L DS +
Sbjct: 644 LQKKITNLKITCEKIEALEQENSELERENRKLKKTL-----------------DSFKNLT 686
Query: 198 ITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAET 257
ES + +S +DE + N + AS+ E+ E+
Sbjct: 687 FQLESL------EKENSQLDEENLELRRNV--------ESLKCASMKMAQLQLENKELES 732
Query: 258 PSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQEL 317
L K+S T VS L +++QK EN + ++L++ LQ+L
Sbjct: 733 EKEQLKKGLELLKASFKKTERLE---VSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 318 SDQQQMVQELTAEN-------EKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERV 370
+ Q +Q+ E E+L E LE Q + +QL +EN++L Q +
Sbjct: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ--QAEI 847
Query: 371 KNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKR 430
K+ TT E +++ G LE+ K + I ++ L+++E+EN+ E++KR
Sbjct: 848 KD---TTLEENNVKI-----GNLEKENKTLSKEIGIYKESCVRLKELEKENK---ELVKR 896
Query: 431 LKEENEKL---NEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQG---EKQKA 484
+ + L E L E+ M LE+ LE + + L Q + K
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKL 956
Query: 485 TEASAVEQTAESCEVQEMLKVARAEKDLLELSC--NELRQELLKANGEIKHVSSLLAKVE 542
E+ +S E++E K+A E L E + +LRQEL V+
Sbjct: 957 LESKLESTLKKSLEIKEE-KIAALEARLEESTNYNQQLRQEL--------------KTVK 1001
Query: 543 KDYSYLKEICDHQ-----AEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAV 597
K+Y LK+ D + + +S K + ++ E+ E+ +K+ + E+E +A
Sbjct: 1002 KNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAE 1061
Query: 598 KLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDI 657
K + +LE+ L+ Q L+RQ +L +Q T + + + ++ + + +
Sbjct: 1062 KQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ--NTTLQTQNAKLQVENSTLNSQST 1119
Query: 658 KCEAQQELRTVKRKLLEEEEKNARLQKE 685
Q +++ LE E ++ ++E
Sbjct: 1120 SLMNQNAQLLIQQSSLENENESVIKERE 1147
Score = 72.0 bits (175), Expect = 2e-12
Identities = 90/436 (20%), Positives = 194/436 (44%), Gaps = 21/436 (4%)
Query: 268 PFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQEL 327
P SS + SP S L+ ++ + +EL+ ++L D +Q ++++
Sbjct: 225 PHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQM 284
Query: 328 TAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQ 387
E ++L E L + R ++L EK + + +++++E +E ++ ++E
Sbjct: 285 EIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV--DKLESEVSRYKE-RLHDIEF 341
Query: 388 KCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERH 447
+ E+ + + + LL + L L + E+ K + KL++ +E+ER
Sbjct: 342 YKARV-EELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHD-MEMERD 399
Query: 448 NNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQ---KATEASAVEQTAESCEVQEMLK 504
+ + L E +TLE + ++ HL E + + +E S Q + EV E+
Sbjct: 400 MDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTS 459
Query: 505 VARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLK---EICDHQAEQLSR 561
+ ++ S + +EL ++ +S + K+EK+ L EI +++ Q +
Sbjct: 460 SRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQ 519
Query: 562 TSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKL------HNNQLISEL-ESSVIK 614
+ Q + + E +++TI L + E R +K+ H NQ +S L + S I
Sbjct: 520 SLQNCQNLSKDLMKEKAQLEKTIETLRENSE--RQIKILEQENEHLNQTVSSLRQRSQIS 577
Query: 615 LEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLE 674
E + D+E++ K L + +KE + + + + + + K E + ++ +L
Sbjct: 578 AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK-EKGERAEELENELHH 636
Query: 675 EEEKNARLQKELGDVQ 690
E++N LQK++ +++
Sbjct: 637 LEKENELLQKKITNLK 652
Score = 35.8 bits (81), Expect = 0.14
Identities = 68/333 (20%), Positives = 126/333 (37%), Gaps = 40/333 (12%)
Query: 145 IRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSF 204
++ LE +N N Q ++ L+ + L+E+ L+ + T +S + + Q +
Sbjct: 1069 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1128
Query: 205 ---GSPTGNQMSSDIDEYK--KNIHGNALRTSGSSSSDVTKASLSPD--ASDFE------ 251
S N+ S I E + K+++ + ++ D K L + AS++E
Sbjct: 1129 LIQQSSLENENESVIKEREDLKSLYDSLIK-------DHEKLELLHERQASEYESLISKH 1181
Query: 252 ------HITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHS 305
H E R L N K E L EK+ +NH +
Sbjct: 1182 GTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL------EKMLKVEQEKMLLENKNHET 1235
Query: 306 TAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNL 365
A E + E +L E E L + L++ + + +L E KL
Sbjct: 1236 VAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQ 1295
Query: 366 LQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGAL 425
Q+ + +T+ EL + G LE+ E LL+ Q L R + E+N +
Sbjct: 1296 YQQL---DITSTKLNNQCELLSQLKGNLEE---ENRHLLDQIQTLMLQNRTLLEQNMESK 1349
Query: 426 EMIKRLKEENEKLNEFLELERHNNNMMAKTLEE 458
++ E+ + +++ EL R + K +++
Sbjct: 1350 DLFH--VEQRQYIDKLNELRRQKEKLEEKIMDQ 1380
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 85.9 bits (211), Expect = 1e-16
Identities = 143/640 (22%), Positives = 273/640 (42%), Gaps = 108/640 (16%)
Query: 90 RELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALE 149
R+ L + K +++L SE+ +YKE R + E A + + +T+ M+
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKE-RLHDIEFYKARVEELKEDNQVLLETKTMLEDQL 367
Query: 150 EKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTG 209
E + +L +LE+EN LK KL +E
Sbjct: 368 EGTRARSDKLHELEKENLQLKAKLHDME-------------------------------- 395
Query: 210 NQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPF 269
M D+D K L + K S+ D S E SR + P
Sbjct: 396 --MERDMDRKKIE----ELMEENMTLEMAQKQSM--DESLHLGWELEQISRTSELSEAPQ 447
Query: 270 KSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTA 329
KS + V+EL+ + L K++ ++ T EEL+ T+ + + ++
Sbjct: 448 KSLG--------HEVNELTSSRLL-KLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498
Query: 330 ENEKLVDEKTILETSFHQHR---ERAEQLSQENEKLMNLLQERVKN-EEPTTQEGKIIE- 384
EN++L + ILE Q + + + LS++ K L++ ++ E + ++ KI+E
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558
Query: 385 ----LEQKCTGILEQGRFERE----------KLLNIQQQLTCS-LRKVEEENQGALEMIK 429
L Q + + ++ + E K+L+ + T S L K+E E + + ++
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 430 RLKEENEKLNEFLELERHN----NNMMAKTLEECRVTLE----------GLKMENGSLKS 475
KE+ E+ E LE E H+ N ++ K + ++T E L+ EN LK
Sbjct: 619 HYKEKGERAEE-LENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677
Query: 476 HLQGEKQKATEASAVEQ-----TAESCEVQ---EMLKVARAEKDLLELSCNELRQELLKA 527
L K + ++E+ E+ E++ E LK A + L+L EL E +
Sbjct: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737
Query: 528 NGEIKHVSSLLAKVEK-DYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFE 586
++ + + K E+ + SY + D + ++L +T +K + ++E++D+ E
Sbjct: 738 KKGLELLKASFKKTERLEVSY--QGLDIENQRLQKTLENSNKKIQQLESELQDL-----E 790
Query: 587 LEDQVEQHRAVKLH-NNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQA 645
+E+Q Q +L +++ + +LE LE++ S LE+ K L K+ K R QA
Sbjct: 791 MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR-----LRQQA 845
Query: 646 DLQTAVVVANDIKC-EAQQELRTVKRKLLEEEEKNARLQK 684
+++ + N++K ++E +T+ +++ +E RL++
Sbjct: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
Score = 82.8 bits (203), Expect = 1e-15
Identities = 141/627 (22%), Positives = 254/627 (40%), Gaps = 90/627 (14%)
Query: 81 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 140
E L ++E ++ + E +++ EL+ YKEK E + L +
Sbjct: 588 ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK----GERAEELENELHHLEKENEL 643
Query: 141 TEPMIRALE---EKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTS 197
+ I L+ EK + ++E S+LE ENR LK+ L DS +
Sbjct: 644 LQKKITNLKITCEKIEALEQENSELERENRKLKKTL-----------------DSFKNLT 686
Query: 198 ITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAET 257
ES + +S +DE + N + AS+ E+ E+
Sbjct: 687 FQLESL------EKENSQLDEENLELRRNV--------ESLKCASMKMAQLQLENKELES 732
Query: 258 PSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQEL 317
L K+S T VS L +++QK EN + ++L++ LQ+L
Sbjct: 733 EKEQLKKGLELLKASFKKTERLE---VSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 318 SDQQQMVQELTAEN-------EKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERV 370
+ Q +Q+ E E+L E LE Q + +QL +EN++L Q +
Sbjct: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ--QAEI 847
Query: 371 KNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKR 430
K+ TT E +++ G LE+ K + I ++ L+++E+EN+ E++KR
Sbjct: 848 KD---TTLEENNVKI-----GNLEKENKTLSKEIGIYKESCVRLKELEKENK---ELVKR 896
Query: 431 LKEENEKL---NEFLELERHNNNMMAKTLEECRVTLE--GLKMENGSLKSHLQGEKQKAT 485
+ + L E L E+ M LE+ LE GL E ++ K
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLL 956
Query: 486 EASAVEQTAESCEVQEMLKVARAEKDLLELSC--NELRQELLKANGEIKHVSSLLAKVEK 543
E+ +S E++E K+A E L E + +LRQEL V+K
Sbjct: 957 ESKLESTLKKSLEIKEE-KIAALEARLEESTNYNQQLRQEL--------------KTVKK 1001
Query: 544 DYSYLKEICDHQ-----AEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVK 598
+Y LK+ D + + +S K + ++ E+ E+ +K+ + E+E +A K
Sbjct: 1002 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1061
Query: 599 LHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIK 658
+ +LE+ L+ Q L+RQ +L +Q T + + + ++ + + +
Sbjct: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ--NTTLQTQNAKLQVENSTLNSQSTS 1119
Query: 659 CEAQQELRTVKRKLLEEEEKNARLQKE 685
Q +++ LE E ++ ++E
Sbjct: 1120 LMNQNAQLLIQQSSLENENESVIKERE 1146
Score = 81.6 bits (200), Expect = 2e-15
Identities = 133/573 (23%), Positives = 239/573 (41%), Gaps = 87/573 (15%)
Query: 140 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSIT 199
++E I+ LE++N++ + +S L + +++ E + N S SS + I
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607
Query: 200 QESSFGSPTGNQMSSDIDEYKKN----------IHG----NALRTSGSSSSDVTKASLSP 245
E Q+ +++ YK+ +H N L ++ +T +
Sbjct: 608 FEK-------RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKI-- 658
Query: 246 DASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENH-- 303
+A + E+ E +R L T + FK+ L SL ++ +++E +
Sbjct: 659 EALEQENSELERENRKLKKTLDSFKNLT-------------FQLESLEKENSQLDEENLE 705
Query: 304 -HSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQ----E 358
E L+ +++ Q +EL +E E+L +L+ SF + ER E Q E
Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKK-TERLEVSYQGLDIE 764
Query: 359 NEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVE 418
N++L L+ K + E + +E+E + Q E K+ + + L ++E
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQDLEMENQTL----QKNLEELKISSKR------LEQLE 814
Query: 419 EENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQ 478
+EN+ + +L+++ ++L + + R + TLEE V + L+ EN +L +
Sbjct: 815 KENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIG 874
Query: 479 GEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLL 538
K+ +E+ E +E++K A + L +L E LK + L
Sbjct: 875 IYKESCVRLKELEK-----ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLT 929
Query: 539 AKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASES----DAEIKDMKETIFELEDQVEQH 594
++EK KE H EQ + KL E ES EIK+ E I LE ++E+
Sbjct: 930 HELEK-IGLNKERLLHD-EQSTDDRYKLLESKLESTLKKSLEIKE--EKIAALEARLEES 985
Query: 595 RAVKLHNNQLISELESSVIKLE--EQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVV 652
+N QL EL++ E +Q+ D ER +++ + + E +W R
Sbjct: 986 TN---YNQQLRQELKTVKKNYEALKQRQDEERMVQS-SPPISGEDNKWERESQ------- 1034
Query: 653 VANDIKCEAQQELRTVKRKLLEEEEKNARLQKE 685
E +EL VK +L+E E NA LQ E
Sbjct: 1035 -------ETTRELLKVKDRLIEVERNNATLQAE 1060
Score = 72.0 bits (175), Expect = 2e-12
Identities = 90/436 (20%), Positives = 194/436 (44%), Gaps = 21/436 (4%)
Query: 268 PFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQEL 327
P SS + SP S L+ ++ + +EL+ ++L D +Q ++++
Sbjct: 225 PHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQM 284
Query: 328 TAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQ 387
E ++L E L + R ++L EK + + +++++E +E ++ ++E
Sbjct: 285 EIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV--DKLESEVSRYKE-RLHDIEF 341
Query: 388 KCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERH 447
+ E+ + + + LL + L L + E+ K + KL++ +E+ER
Sbjct: 342 YKARV-EELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHD-MEMERD 399
Query: 448 NNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQ---KATEASAVEQTAESCEVQEMLK 504
+ + L E +TLE + ++ HL E + + +E S Q + EV E+
Sbjct: 400 MDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTS 459
Query: 505 VARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLK---EICDHQAEQLSR 561
+ ++ S + +EL ++ +S + K+EK+ L EI +++ Q +
Sbjct: 460 SRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQ 519
Query: 562 TSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKL------HNNQLISEL-ESSVIK 614
+ Q + + E +++TI L + E R +K+ H NQ +S L + S I
Sbjct: 520 SLQNCQNLSKDLMKEKAQLEKTIETLRENSE--RQIKILEQENEHLNQTVSSLRQRSQIS 577
Query: 615 LEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLE 674
E + D+E++ K L + +KE + + + + + + K E + ++ +L
Sbjct: 578 AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK-EKGERAEELENELHH 636
Query: 675 EEEKNARLQKELGDVQ 690
E++N LQK++ +++
Sbjct: 637 LEKENELLQKKITNLK 652
Score = 35.8 bits (81), Expect = 0.14
Identities = 68/333 (20%), Positives = 126/333 (37%), Gaps = 40/333 (12%)
Query: 145 IRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSF 204
++ LE +N N Q ++ L+ + L+E+ L+ + T +S + + Q +
Sbjct: 1068 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127
Query: 205 ---GSPTGNQMSSDIDEYK--KNIHGNALRTSGSSSSDVTKASLSPD--ASDFE------ 251
S N+ S I E + K+++ + ++ D K L + AS++E
Sbjct: 1128 LIQQSSLENENESVIKEREDLKSLYDSLIK-------DHEKLELLHERQASEYESLISKH 1180
Query: 252 ------HITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHS 305
H E R L N K E L EK+ +NH +
Sbjct: 1181 GTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL------EKMLKVEQEKMLLENKNHET 1234
Query: 306 TAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNL 365
A E + E +L E E L + L++ + + +L E KL
Sbjct: 1235 VAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQ 1294
Query: 366 LQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGAL 425
Q+ + +T+ EL + G LE+ E LL+ Q L R + E+N +
Sbjct: 1295 YQQL---DITSTKLNNQCELLSQLKGNLEE---ENRHLLDQIQTLMLQNRTLLEQNMESK 1348
Query: 426 EMIKRLKEENEKLNEFLELERHNNNMMAKTLEE 458
++ E+ + +++ EL R + K +++
Sbjct: 1349 DLFH--VEQRQYIDKLNELRRQKEKLEEKIMDQ 1379
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.304 0.121 0.318
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,895,463
Number of Sequences: 37866
Number of extensions: 1328418
Number of successful extensions: 18097
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 419
Number of HSP's successfully gapped in prelim test: 1238
Number of HSP's that attempted gapping in prelim test: 7738
Number of HSP's gapped (non-prelim): 6249
length of query: 709
length of database: 18,247,518
effective HSP length: 109
effective length of query: 600
effective length of database: 14,120,124
effective search space: 8472074400
effective search space used: 8472074400
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.