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Search of human proteins with 75750466
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|75750466 spectrin domain with coiled-coils 1 NSP5b3a [Homo
sapiens]
(790 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|75750466 spectrin domain with coiled-coils 1 NSP5b3a [Homo sa... 1523 0.0
gi|75750472 spectrin domain with coiled-coils 1 NSP5b3b [Homo sa... 1513 0.0
gi|75750468 spectrin domain with coiled-coils 1 NSP5a3a [Homo sa... 1345 0.0
gi|75750474 spectrin domain with coiled-coils 1 NSP5a3b [Homo sa... 1335 0.0
gi|224451082 cytospin A [Homo sapiens] 434 e-121
gi|224451080 cytospin A [Homo sapiens] 434 e-121
gi|38044112 restin isoform b [Homo sapiens] 102 2e-21
gi|4506751 restin isoform a [Homo sapiens] 102 2e-21
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 100 4e-21
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 99 2e-20
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 96 1e-19
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 96 1e-19
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 96 2e-19
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 94 5e-19
gi|71061468 centromere protein E [Homo sapiens] 94 5e-19
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 93 1e-18
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 93 1e-18
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 92 2e-18
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 91 3e-18
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 91 3e-18
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 91 4e-18
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 91 4e-18
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 91 4e-18
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 90 7e-18
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 90 7e-18
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 88 3e-17
gi|21735548 centrosomal protein 2 [Homo sapiens] 88 3e-17
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 88 4e-17
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 86 1e-16
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 86 1e-16
>gi|75750466 spectrin domain with coiled-coils 1 NSP5b3a [Homo
sapiens]
Length = 790
Score = 1523 bits (3942), Expect = 0.0
Identities = 790/790 (100%), Positives = 790/790 (100%)
Query: 1 MRSAAKPWNPAIRAGGHGPDRVRPLPAASSGMKSSKSSTSLAFESRLSRLKRASSEDTLN 60
MRSAAKPWNPAIRAGGHGPDRVRPLPAASSGMKSSKSSTSLAFESRLSRLKRASSEDTLN
Sbjct: 1 MRSAAKPWNPAIRAGGHGPDRVRPLPAASSGMKSSKSSTSLAFESRLSRLKRASSEDTLN 60
Query: 61 KPGSTAASGVVRLKKTATAGAISELTESRLRSGTGAFTTTKRTGIPAPREFSVTVSRERS 120
KPGSTAASGVVRLKKTATAGAISELTESRLRSGTGAFTTTKRTGIPAPREFSVTVSRERS
Sbjct: 61 KPGSTAASGVVRLKKTATAGAISELTESRLRSGTGAFTTTKRTGIPAPREFSVTVSRERS 120
Query: 121 VPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAK 180
VPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAK
Sbjct: 121 VPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAK 180
Query: 181 DSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKEL 240
DSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKEL
Sbjct: 181 DSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKEL 240
Query: 241 SDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEY 300
SDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEY
Sbjct: 241 SDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEY 300
Query: 301 KKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS 360
KKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS
Sbjct: 301 KKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS 360
Query: 361 SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKT 420
SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKT
Sbjct: 361 SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKT 420
Query: 421 ILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFE 480
ILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFE
Sbjct: 421 ILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFE 480
Query: 481 REKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEEC 540
REKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEEC
Sbjct: 481 REKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEEC 540
Query: 541 RVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE 600
RVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE
Sbjct: 541 RVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE 600
Query: 601 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKD 660
LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKD
Sbjct: 601 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKD 660
Query: 661 MKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEE 720
MKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEE
Sbjct: 661 MKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEE 720
Query: 721 WRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSR 780
WRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSR
Sbjct: 721 WRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSR 780
Query: 781 AAPPSLGSVS 790
AAPPSLGSVS
Sbjct: 781 AAPPSLGSVS 790
>gi|75750472 spectrin domain with coiled-coils 1 NSP5b3b [Homo
sapiens]
Length = 1068
Score = 1513 bits (3916), Expect = 0.0
Identities = 784/784 (100%), Positives = 784/784 (100%)
Query: 1 MRSAAKPWNPAIRAGGHGPDRVRPLPAASSGMKSSKSSTSLAFESRLSRLKRASSEDTLN 60
MRSAAKPWNPAIRAGGHGPDRVRPLPAASSGMKSSKSSTSLAFESRLSRLKRASSEDTLN
Sbjct: 1 MRSAAKPWNPAIRAGGHGPDRVRPLPAASSGMKSSKSSTSLAFESRLSRLKRASSEDTLN 60
Query: 61 KPGSTAASGVVRLKKTATAGAISELTESRLRSGTGAFTTTKRTGIPAPREFSVTVSRERS 120
KPGSTAASGVVRLKKTATAGAISELTESRLRSGTGAFTTTKRTGIPAPREFSVTVSRERS
Sbjct: 61 KPGSTAASGVVRLKKTATAGAISELTESRLRSGTGAFTTTKRTGIPAPREFSVTVSRERS 120
Query: 121 VPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAK 180
VPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAK
Sbjct: 121 VPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAK 180
Query: 181 DSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKEL 240
DSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKEL
Sbjct: 181 DSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKEL 240
Query: 241 SDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEY 300
SDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEY
Sbjct: 241 SDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEY 300
Query: 301 KKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS 360
KKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS
Sbjct: 301 KKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS 360
Query: 361 SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKT 420
SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKT
Sbjct: 361 SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKT 420
Query: 421 ILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFE 480
ILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFE
Sbjct: 421 ILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFE 480
Query: 481 REKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEEC 540
REKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEEC
Sbjct: 481 REKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEEC 540
Query: 541 RVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE 600
RVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE
Sbjct: 541 RVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE 600
Query: 601 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKD 660
LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKD
Sbjct: 601 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKD 660
Query: 661 MKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEE 720
MKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEE
Sbjct: 661 MKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEE 720
Query: 721 WRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSR 780
WRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSR
Sbjct: 721 WRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSR 780
Query: 781 AAPP 784
AAPP
Sbjct: 781 AAPP 784
>gi|75750468 spectrin domain with coiled-coils 1 NSP5a3a [Homo
sapiens]
Length = 709
Score = 1345 bits (3481), Expect = 0.0
Identities = 696/696 (100%), Positives = 696/696 (100%)
Query: 95 GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKP 154
GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKP
Sbjct: 14 GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKP 73
Query: 155 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 214
KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG
Sbjct: 74 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 133
Query: 215 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS 274
TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS
Sbjct: 134 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS 193
Query: 275 CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI 334
CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI
Sbjct: 194 CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI 253
Query: 335 TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT 394
TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT
Sbjct: 254 TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT 313
Query: 395 LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE 454
LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE
Sbjct: 314 LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE 373
Query: 455 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 514
EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE
Sbjct: 374 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 433
Query: 515 ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT 574
ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT
Sbjct: 434 ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT 493
Query: 575 AESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICD 634
AESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICD
Sbjct: 494 AESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICD 553
Query: 635 HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI 694
HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI
Sbjct: 554 HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI 613
Query: 695 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL 754
KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL
Sbjct: 614 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL 673
Query: 755 EEEEKNARLQKELGDVQGHGRVVTSRAAPPSLGSVS 790
EEEEKNARLQKELGDVQGHGRVVTSRAAPPSLGSVS
Sbjct: 674 EEEEKNARLQKELGDVQGHGRVVTSRAAPPSLGSVS 709
>gi|75750474 spectrin domain with coiled-coils 1 NSP5a3b [Homo
sapiens]
Length = 987
Score = 1335 bits (3455), Expect = 0.0
Identities = 690/690 (100%), Positives = 690/690 (100%)
Query: 95 GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKP 154
GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKP
Sbjct: 14 GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKP 73
Query: 155 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 214
KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG
Sbjct: 74 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 133
Query: 215 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS 274
TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS
Sbjct: 134 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS 193
Query: 275 CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI 334
CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI
Sbjct: 194 CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI 253
Query: 335 TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT 394
TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT
Sbjct: 254 TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT 313
Query: 395 LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE 454
LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE
Sbjct: 314 LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE 373
Query: 455 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 514
EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE
Sbjct: 374 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 433
Query: 515 ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT 574
ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT
Sbjct: 434 ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT 493
Query: 575 AESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICD 634
AESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICD
Sbjct: 494 AESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICD 553
Query: 635 HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI 694
HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI
Sbjct: 554 HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI 613
Query: 695 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL 754
KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL
Sbjct: 614 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL 673
Query: 755 EEEEKNARLQKELGDVQGHGRVVTSRAAPP 784
EEEEKNARLQKELGDVQGHGRVVTSRAAPP
Sbjct: 674 EEEEKNARLQKELGDVQGHGRVVTSRAAPP 703
>gi|224451082 cytospin A [Homo sapiens]
Length = 1117
Score = 434 bits (1115), Expect = e-121
Identities = 287/783 (36%), Positives = 441/783 (56%), Gaps = 57/783 (7%)
Query: 27 AASSGMKSSKSSTSLAFESRLSRLKRASSEDTLN--KPGSTAASGVVRLKKTATAGAISE 84
+AS+G K K T+ + K SS+D L G T +GV K T + A S
Sbjct: 33 SASTGGKLVKPGTAASLS------KTKSSDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSA 86
Query: 85 ------LTESRLRSGTGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSS 138
E++ + TG ++TKR+ +E S T R R R + +K S+ +
Sbjct: 87 SAPAMTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTR-LNQSKKLPSAGQGA 145
Query: 139 NTPTPTKHLRTPS--------TKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSE 190
N K R+ + +K K +N+ ++AALE++V++LL AK KD EI LR+E
Sbjct: 146 NDMALAKRSRSRTATECDVRMSKSKSDNQISDRAALEAKVKDLLTLAKTKDVEILHLRNE 205
Query: 191 LKKYKEKRTLNAEGTDALGPNVDGTSVS--PGDTEPMIRALEEKNKNFQKELSDLEEENR 248
L+ + + +N + ++ + T ++ P D E + L+E+N ++EL+ L+ ENR
Sbjct: 206 LRDMRAQLGINEDHSEGDEKSEKETIMAHQPTDVESTLLQLQEQNTAIREELNQLKNENR 265
Query: 249 VLKEKLIYLEHS-----PNSEGAASHTGDSSCPTSITQESSFGSPTGNQ----------- 292
+LK++L L S NSE + S T Q G+ T +
Sbjct: 266 MLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVEDL 325
Query: 293 MSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKS 352
+S D + + H N++ S S+V + S D + P SS S S
Sbjct: 326 LSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSD---------DALDAPSSSESEGIPS 376
Query: 353 SKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAEN 412
+ S GSS N+ SE+S+A LTE+I +MEEN HST+EELQATLQEL+D QQ+ QEL +EN
Sbjct: 377 IERSRKGSSGNA-SEVSVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSEN 435
Query: 413 EKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQER----VKNEEPTTQEGKIIELEQ 468
E+L +EK IL S Q ++ E S++ E +LL E V +E+ + G+ +ELEQ
Sbjct: 436 ERLGEEKVILMESLCQQSDKLEHFSRQIEYFRSLLDEHHISYVIDED--VKSGRYMELEQ 493
Query: 469 KCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERH 528
+ + E RFERE+LL +QQ L+ +L+ E++N+ A EMI LKE + + +E E+
Sbjct: 494 RYMDLAENARFEREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQK 553
Query: 529 NNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVAR 588
+A TLEE + T+ ++E LK+ L+ EKQK E ++ + + ++Q++L+ R
Sbjct: 554 GKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVR 613
Query: 589 AEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQ 648
+K+ E + L+++L + + +AKVE +Y +E Q E L+ T KL+
Sbjct: 614 LDKEKAETLASSLQEDLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLR 673
Query: 649 EKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLK 708
E + E DMKETIFELED+VEQHRAVKLH+N +IS+LE++V KL++QK D+ER++K
Sbjct: 674 SDLDEKETERSDMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIK 733
Query: 709 TLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELG 768
TL ++++EE+ EWR+FQADLQTAVV+ANDIK EAQ+E+ +KR+L E +EKN +L KEL
Sbjct: 734 TLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELE 793
Query: 769 DVQ 771
+++
Sbjct: 794 EIK 796
Score = 30.8 bits (68), Expect = 5.1
Identities = 46/198 (23%), Positives = 81/198 (40%), Gaps = 16/198 (8%)
Query: 166 LESQVRELLAEAKAKDSEINRLRSELKKYK-EKRTLNAEGTDALGPNVDGTSVSP---GD 221
LE+ V++L + + EI L L++ E R A+ A+ D S + GD
Sbjct: 714 LENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGD 773
Query: 222 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIY-LEHSPNSEGAASHTGDSSCPTSIT 280
+ + +EKN+ KEL +++ + + +Y ++ + AA G S T
Sbjct: 774 LKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSST 833
Query: 281 QESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPS 340
SS +PT + D +A + +++ + + LSP A +P
Sbjct: 834 --SSEPTPTVKTLIKSFD--------SASQVPNPAAAAIPRTPLSPSPMKTPPAAAVSPM 883
Query: 341 RPLSSTSNPFKSSKCSTA 358
+ S S P +SK TA
Sbjct: 884 Q-RHSISGPISTSKPLTA 900
>gi|224451080 cytospin A [Homo sapiens]
Length = 1117
Score = 434 bits (1115), Expect = e-121
Identities = 287/783 (36%), Positives = 441/783 (56%), Gaps = 57/783 (7%)
Query: 27 AASSGMKSSKSSTSLAFESRLSRLKRASSEDTLN--KPGSTAASGVVRLKKTATAGAISE 84
+AS+G K K T+ + K SS+D L G T +GV K T + A S
Sbjct: 33 SASTGGKLVKPGTAASLS------KTKSSDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSA 86
Query: 85 ------LTESRLRSGTGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSS 138
E++ + TG ++TKR+ +E S T R R R + +K S+ +
Sbjct: 87 SAPAMTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTR-LNQSKKLPSAGQGA 145
Query: 139 NTPTPTKHLRTPS--------TKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSE 190
N K R+ + +K K +N+ ++AALE++V++LL AK KD EI LR+E
Sbjct: 146 NDMALAKRSRSRTATECDVRMSKSKSDNQISDRAALEAKVKDLLTLAKTKDVEILHLRNE 205
Query: 191 LKKYKEKRTLNAEGTDALGPNVDGTSVS--PGDTEPMIRALEEKNKNFQKELSDLEEENR 248
L+ + + +N + ++ + T ++ P D E + L+E+N ++EL+ L+ ENR
Sbjct: 206 LRDMRAQLGINEDHSEGDEKSEKETIMAHQPTDVESTLLQLQEQNTAIREELNQLKNENR 265
Query: 249 VLKEKLIYLEHS-----PNSEGAASHTGDSSCPTSITQESSFGSPTGNQ----------- 292
+LK++L L S NSE + S T Q G+ T +
Sbjct: 266 MLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVEDL 325
Query: 293 MSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKS 352
+S D + + H N++ S S+V + S D + P SS S S
Sbjct: 326 LSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSD---------DALDAPSSSESEGIPS 376
Query: 353 SKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAEN 412
+ S GSS N+ SE+S+A LTE+I +MEEN HST+EELQATLQEL+D QQ+ QEL +EN
Sbjct: 377 IERSRKGSSGNA-SEVSVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSEN 435
Query: 413 EKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQER----VKNEEPTTQEGKIIELEQ 468
E+L +EK IL S Q ++ E S++ E +LL E V +E+ + G+ +ELEQ
Sbjct: 436 ERLGEEKVILMESLCQQSDKLEHFSRQIEYFRSLLDEHHISYVIDED--VKSGRYMELEQ 493
Query: 469 KCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERH 528
+ + E RFERE+LL +QQ L+ +L+ E++N+ A EMI LKE + + +E E+
Sbjct: 494 RYMDLAENARFEREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQK 553
Query: 529 NNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVAR 588
+A TLEE + T+ ++E LK+ L+ EKQK E ++ + + ++Q++L+ R
Sbjct: 554 GKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVR 613
Query: 589 AEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQ 648
+K+ E + L+++L + + +AKVE +Y +E Q E L+ T KL+
Sbjct: 614 LDKEKAETLASSLQEDLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLR 673
Query: 649 EKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLK 708
E + E DMKETIFELED+VEQHRAVKLH+N +IS+LE++V KL++QK D+ER++K
Sbjct: 674 SDLDEKETERSDMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIK 733
Query: 709 TLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELG 768
TL ++++EE+ EWR+FQADLQTAVV+ANDIK EAQ+E+ +KR+L E +EKN +L KEL
Sbjct: 734 TLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELE 793
Query: 769 DVQ 771
+++
Sbjct: 794 EIK 796
Score = 30.8 bits (68), Expect = 5.1
Identities = 46/198 (23%), Positives = 81/198 (40%), Gaps = 16/198 (8%)
Query: 166 LESQVRELLAEAKAKDSEINRLRSELKKYK-EKRTLNAEGTDALGPNVDGTSVSP---GD 221
LE+ V++L + + EI L L++ E R A+ A+ D S + GD
Sbjct: 714 LENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGD 773
Query: 222 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIY-LEHSPNSEGAASHTGDSSCPTSIT 280
+ + +EKN+ KEL +++ + + +Y ++ + AA G S T
Sbjct: 774 LKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSST 833
Query: 281 QESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPS 340
SS +PT + D +A + +++ + + LSP A +P
Sbjct: 834 --SSEPTPTVKTLIKSFD--------SASQVPNPAAAAIPRTPLSPSPMKTPPAAAVSPM 883
Query: 341 RPLSSTSNPFKSSKCSTA 358
+ S S P +SK TA
Sbjct: 884 Q-RHSISGPISTSKPLTA 900
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 102 bits (253), Expect = 2e-21
Identities = 135/639 (21%), Positives = 271/639 (42%), Gaps = 85/639 (13%)
Query: 156 QENEGGEKAA----LESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPN 211
Q + E+AA +E+ +L+ K K++ + +RS+L K +++ + E D L
Sbjct: 632 QNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME--DTLN-K 688
Query: 212 VDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTG 271
+ + + E L+ K K + + + + +EKL+ L+
Sbjct: 689 LQEAEIKVKELE----VLQAKCNEQTKVIDNFTSQLKATEEKLLDLD------------- 731
Query: 272 DSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDF 331
++ + SS G ++ ++ +K I + + SS KAS
Sbjct: 732 ------ALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESS----KAS-------- 773
Query: 332 EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEEL 391
IT E R L T+ S+ S E L L EK + E S +
Sbjct: 774 -SITRELQGRELKLTNLQENLSEVSQV----KETLEKELQILKEKFAEASEEAVSVQRSM 828
Query: 392 QATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERV 451
Q T+ +L +++ L+++ EKL + +E F + ER EQL + EKL N + E +
Sbjct: 829 QETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 888
Query: 452 K------------NEEPTTQEGKIIELEQKCTGILEQGRFEREKL----LNIQQQLTCSL 495
K N+E +E + EL+ K T E F ++ + + +Q +
Sbjct: 889 KMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAA 948
Query: 496 RKVEEENQGALEMIKRLKEENEKL----NEFLELERHNNNMMAKTLEECRVTLEGLKMEN 551
+K EEE + E+ ++L + +K+ N+ EL+ ++T + L+ L+
Sbjct: 949 KKHEEEKK---ELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1005
Query: 552 GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 611
+ L+G +++ + +++ E + + K A+ +D +++ ++ +E +
Sbjct: 1006 LDTEDKLKGAREE--NSGLLQELEELRKQADKAKAAQTAEDAMQI-MEQMTKEKTETLAS 1062
Query: 612 IKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKL---QEKASESDAEIKDMKETIFEL 668
++ AK++ + LKE E+L+++ L +K E EI+ +K+ +
Sbjct: 1063 LEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQK 1122
Query: 669 EDQVEQHRAVKLHNNQLISEL------ESSVIKLEEQKSDLERQLKTLTKQMKEETEEWR 722
Q+ A++ N +L EL +S KLEE++S L QL + K+ + ++
Sbjct: 1123 SQQLS---ALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDAD 1179
Query: 723 RFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNA 761
+A LQ ++ + + + E EL ++ ++ +NA
Sbjct: 1180 EEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENA 1218
Score = 84.0 bits (206), Expect = 5e-16
Identities = 146/715 (20%), Positives = 275/715 (38%), Gaps = 106/715 (14%)
Query: 98 TTTKRTGIPAPREFSVTVSRERSVPRGPS-NPRKSVSSPTSSNTPTPTKHLRTPSTKPKQ 156
TT + A R T S S+ R PS + S+SS SS + P++ T +
Sbjct: 286 TTPAKAKANAVRRVMATTSA--SLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRY 343
Query: 157 ENEGGEKAALESQVRE-------LLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALG 209
+ AL+ ++E LLAE + +E+ + S + + +++ L +G D
Sbjct: 344 ARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQ-- 401
Query: 210 PNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASH 269
+V M+ A + + L+ LEEE R +++ +E ++G
Sbjct: 402 -HVLELEAKMDQLRTMVEAADREKVEL---LNQLEEEKRKVEDLQFRVEEESITKGDLEV 457
Query: 270 TGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 329
S + E ++ E ++ + N + DV + S
Sbjct: 458 ATVSEKSRIMELEKDLALRV-----QEVAELRRRLESN------KPAGDVDMS-----LS 501
Query: 330 DFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAE 389
+ I++ ++ T + + + SL E EE H +
Sbjct: 502 LLQEISSLQEKLEVTRTDH------------------QREITSLKEHFGAREETHQKEIK 543
Query: 390 ELQATLQELSDQQQMVQ-ELTAENEKLVDE----KTILETSFHQHRERAEQLSQENEKLM 444
L ++LS + + ++ +L N++ D K+ LET+ H++ E+L K
Sbjct: 544 ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK-- 601
Query: 445 NLLQERVKNEEPTTQEGKI-IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQ 503
L E + E TQ K+ ++ + + + Q ER + L L KV +E +
Sbjct: 602 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE 661
Query: 504 GALEMIK---------RLKEENEKLNEFLELERH-------------------NNNMMAK 535
+LE I+ L E + LN+ E E N K
Sbjct: 662 NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLK 721
Query: 536 TLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLE 595
EE + L+ L+ + KS ++ +Q + A E+ + E+++ + ++A E
Sbjct: 722 ATEEKLLDLDALRKASSEGKSEMKKLRQ---QLEAAEKQIKHLEIEKNAESSKASSITRE 778
Query: 596 LSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESD 655
L EL+ L+ N + VS + +EK+ LKE K E + E+
Sbjct: 779 LQGRELKLTNLQEN--LSEVSQVKETLEKELQILKE--------------KFAEASEEAV 822
Query: 656 AEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK 715
+ + M+ET+ +L + EQ + +L L K E K + E QL ++++
Sbjct: 823 SVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE-KDEREEQLIKAKEKLE 881
Query: 716 EETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDV 770
+ E + D + + ND ++++ ++ KL + E + LQK + D+
Sbjct: 882 NDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 936
Score = 83.2 bits (204), Expect = 9e-16
Identities = 141/626 (22%), Positives = 273/626 (43%), Gaps = 102/626 (16%)
Query: 157 ENEGGEKAALESQVRELLAEAKAKD---SEINRLRSELKKYKEKRTLNAEGTDALGPNVD 213
+N + A E ++ +L A KA SE+ +LR +L+ EK+ + E + N +
Sbjct: 714 DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEA-AEKQIKHLE----IEKNAE 768
Query: 214 GTSVSPGDTEPMIRALEEKNKNFQKELSD-------LEEENRVLKEKLIYLEHSPNSEGA 266
+ S E ++ E K N Q+ LS+ LE+E ++LKEK + E
Sbjct: 769 SSKASSITRE--LQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFA----EASEEAV 822
Query: 267 ASHTGDSSCPTSITQ-ESSFGSPTGNQMSSDIDEYKKNIHGNA--LRTSGSSSSDVTKAS 323
+ + Q E F N +SSD+++ ++N+ R + KA
Sbjct: 823 SVQRSMQETVNKLHQKEEQF-----NMLSSDLEKLRENLADMEAKFREKDEREEQLIKAK 877
Query: 324 --LSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME 381
L D ++ ++ + S+ L+ ++ + + V EL L K+ K
Sbjct: 878 EKLENDIAEIMKMSGDNSSQ-LTKMNDELRLKE--------RDVEELQL-----KLTKAN 923
Query: 382 ENHHSTAEELQATLQELSDQQQMVQELTAENE---------KLVDEKTILETSFHQHRER 432
EN A LQ ++++++ + + Q+ A+ KL D + +ETS +Q +E
Sbjct: 924 EN----ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL 979
Query: 433 AEQLSQENEKLMNLLQERVKNEEPTT--QEGKIIELEQKCTGILEQ-----GRFEREKLL 485
+ + + +E ++N + T E K+ ++ +G+L++ + ++ K
Sbjct: 980 KARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAA 1039
Query: 486 NIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECR--VT 543
+ + ++ +E L ++ K+ N KL L+ + NN + L + + +T
Sbjct: 1040 QTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLT 1099
Query: 544 LEGLKMEN--GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNEL 601
+E KME +++ Q QK+ + SA+++ E+ ++ E L +R E S +L
Sbjct: 1100 VENQKMEEFRKEIETLKQAAAQKSQQLSALQE--ENVKLAEELGRSRDEVT----SHQKL 1153
Query: 602 RQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQA---EQLSRTSLKLQEKASESDAEI 658
+E N + LL +++ ++K+ + +A + +S TS L EK DAE+
Sbjct: 1154 EEERSVLNNQ------LLEMKKRESKFIKDADEEKASLQKSISITSALLTEK----DAEL 1203
Query: 659 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK--- 715
+ ++ + L E A LH+ ++ LES +KLE + +LE QLK +Q+
Sbjct: 1204 EKLRNEVTVLRG--ENASAKSLHS--VVQTLESDKVKLELKVKNLELQLKENKRQLSSSS 1259
Query: 716 -------EETEEWRRFQADLQTAVVV 734
+E E + Q D +V+V
Sbjct: 1260 GNTDTQADEDERAQESQIDFLNSVIV 1285
Score = 70.9 bits (172), Expect = 4e-12
Identities = 137/678 (20%), Positives = 267/678 (39%), Gaps = 105/678 (15%)
Query: 167 ESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGT--DALGPNVDGTSVSPGDTEP 224
+S++ EL + + E+ LR L+ K ++ + + + V+ D +
Sbjct: 463 KSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQR 522
Query: 225 MIRALEE----KNKNFQKELS-------DLEEENRVLKEKLIYLEHSPNSEGAASHTGDS 273
I +L+E + + QKE+ L +EN LK KL EH+ S
Sbjct: 523 EITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKL---EHANKENSDVIALWKS 579
Query: 274 SCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEH 333
T+I ++E K + L T + +++ K + D++H
Sbjct: 580 KLETAIASHQQA-----------MEELKVSF-SKGLGTETAEFAEL-KTQIEKMRLDYQH 626
Query: 334 ITAETPSRPLSSTSNPFKSSKCSTAG-SSPNSVSELSLASLTEKIQKMEENHHSTAEELQ 392
++ S + K + A E SL ++ K+ K E+ H E++
Sbjct: 627 EIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQH---LVEME 683
Query: 393 ATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQL---------SQENEKL 443
TL +L + + V+EL K ++ +++ Q + E+L S E +
Sbjct: 684 DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 743
Query: 444 MNLLQERVKNEEPTTQEGKIIELEQ-----KCTGILEQGRFEREKLLNIQQQLTCSLRKV 498
M L+++++ E ++ K +E+E+ K + I + + KL N+Q+ L+ + +V
Sbjct: 744 MKKLRQQLEAAE---KQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLS-EVSQV 799
Query: 499 EEENQGALEMIKRLKEE------------NEKLNEFLELERHNNNMMAKTLEECRVTLEG 546
+E + L+++K E E +N+ L + NM++ LE+ R L
Sbjct: 800 KETLEKELQILKEKFAEASEEAVSVQRSMQETVNK-LHQKEEQFNMLSSDLEKLRENLAD 858
Query: 547 LKM---ENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQ 603
++ E + L K+K E E S + L E L E EL+
Sbjct: 859 MEAKFREKDEREEQLIKAKEKL-ENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL 917
Query: 604 ELLKANGEI----KHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIK 659
+L KAN K + + K E+ + + + ++L R L++K S + +
Sbjct: 918 KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ 977
Query: 660 DMK----------------------ETIFELEDQVEQHRAVKLHNNQLISELESSVIKLE 697
++K +T+ + ED+++ R N+ L+ ELE + +
Sbjct: 978 ELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGARE---ENSGLLQELEELRKQAD 1034
Query: 698 EQKS--DLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTV------ 749
+ K+ E ++ + + KE+TE + QT + N++ + L+ V
Sbjct: 1035 KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKS 1094
Query: 750 KRKLLEEEEKNARLQKEL 767
K L E +K +KE+
Sbjct: 1095 KELLTVENQKMEEFRKEI 1112
Score = 60.1 bits (144), Expect = 8e-09
Identities = 121/591 (20%), Positives = 232/591 (39%), Gaps = 71/591 (12%)
Query: 123 RGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVREL-LAEAKAKD 181
R S+ KS K ++ + E+ E Q REL L +
Sbjct: 734 RKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENL 793
Query: 182 SEINRLRSELKK----YKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQ 237
SE+++++ L+K KEK +E ++ ++ T E L + +
Sbjct: 794 SEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLR 853
Query: 238 KELSDLE---EENRVLKEKLIYLEHSPNSEGAA--SHTGDSSCP-TSITQESSFGSPTGN 291
+ L+D+E E +E+LI + ++ A +GD+S T + E
Sbjct: 854 ENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVE 913
Query: 292 QMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFK 351
++ + K N + + L+ S + + S A E E R LS +
Sbjct: 914 ELQLKLT--KANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKEL-ERKLSDLEKKME 970
Query: 352 SS--KCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELT 409
+S +C + + + E +Q +++ T ++L+ +E S Q ++EL
Sbjct: 971 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1030
Query: 410 AENEKLVDEKTI---LETSFHQHRERAEQLS------QENEKLMN----LLQERVKNEEP 456
+ +K +T ++ +E+ E L+ Q N KL N L + +KN E
Sbjct: 1031 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE 1090
Query: 457 TTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEE- 515
+ +++ +E + +E+ R E E L Q + L ++EEN E + R ++E
Sbjct: 1091 LNKSKELLTVENQK---MEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1147
Query: 516 --NEKL--------NEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSH-------- 557
++KL N+ LE+++ + + EE + + + + L
Sbjct: 1148 TSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLR 1207
Query: 558 -----LQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEI 612
L+GE A +V QT ES +V+ LKV LEL E +++L ++G
Sbjct: 1208 NEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKN-----LELQLKENKRQLSSSSGNT 1262
Query: 613 KHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKE 663
+ ++D + + Q + L+ + LQ K + +++ M E
Sbjct: 1263 D------TQADED----ERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1303
Score = 30.0 bits (66), Expect = 8.7
Identities = 23/134 (17%), Positives = 60/134 (44%), Gaps = 4/134 (2%)
Query: 638 EQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLE 697
E L +++ +E D E ++ + + + ++ + ++Q + ELE+ + +L
Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLR 414
Query: 698 EQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEE 757
+R+ L Q++EE + Q ++ + D++ E K +++E E
Sbjct: 415 TMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSE----KSRIMELE 470
Query: 758 EKNARLQKELGDVQ 771
+ A +E+ +++
Sbjct: 471 KDLALRVQEVAELR 484
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 102 bits (253), Expect = 2e-21
Identities = 135/639 (21%), Positives = 271/639 (42%), Gaps = 85/639 (13%)
Query: 156 QENEGGEKAA----LESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPN 211
Q + E+AA +E+ +L+ K K++ + +RS+L K +++ + E D L
Sbjct: 667 QNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME--DTLN-K 723
Query: 212 VDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTG 271
+ + + E L+ K K + + + + +EKL+ L+
Sbjct: 724 LQEAEIKVKELE----VLQAKCNEQTKVIDNFTSQLKATEEKLLDLD------------- 766
Query: 272 DSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDF 331
++ + SS G ++ ++ +K I + + SS KAS
Sbjct: 767 ------ALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESS----KAS-------- 808
Query: 332 EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEEL 391
IT E R L T+ S+ S E L L EK + E S +
Sbjct: 809 -SITRELQGRELKLTNLQENLSEVSQV----KETLEKELQILKEKFAEASEEAVSVQRSM 863
Query: 392 QATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERV 451
Q T+ +L +++ L+++ EKL + +E F + ER EQL + EKL N + E +
Sbjct: 864 QETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 923
Query: 452 K------------NEEPTTQEGKIIELEQKCTGILEQGRFEREKL----LNIQQQLTCSL 495
K N+E +E + EL+ K T E F ++ + + +Q +
Sbjct: 924 KMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAA 983
Query: 496 RKVEEENQGALEMIKRLKEENEKL----NEFLELERHNNNMMAKTLEECRVTLEGLKMEN 551
+K EEE + E+ ++L + +K+ N+ EL+ ++T + L+ L+
Sbjct: 984 KKHEEEKK---ELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1040
Query: 552 GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 611
+ L+G +++ + +++ E + + K A+ +D +++ ++ +E +
Sbjct: 1041 LDTEDKLKGAREE--NSGLLQELEELRKQADKAKAAQTAEDAMQI-MEQMTKEKTETLAS 1097
Query: 612 IKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKL---QEKASESDAEIKDMKETIFEL 668
++ AK++ + LKE E+L+++ L +K E EI+ +K+ +
Sbjct: 1098 LEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQK 1157
Query: 669 EDQVEQHRAVKLHNNQLISEL------ESSVIKLEEQKSDLERQLKTLTKQMKEETEEWR 722
Q+ A++ N +L EL +S KLEE++S L QL + K+ + ++
Sbjct: 1158 SQQLS---ALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDAD 1214
Query: 723 RFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNA 761
+A LQ ++ + + + E EL ++ ++ +NA
Sbjct: 1215 EEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENA 1253
Score = 87.8 bits (216), Expect = 4e-17
Identities = 159/726 (21%), Positives = 288/726 (39%), Gaps = 93/726 (12%)
Query: 98 TTTKRTGIPAPREFSVTVSRERSVPRGPS-NPRKSVSSPTSSNTPTPTKHLRTPSTKPKQ 156
TT + A R T S S+ R PS + S+SS SS + P++ T +
Sbjct: 286 TTPAKAKANAVRRVMATTSA--SLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRY 343
Query: 157 ENEGGEKAALESQVRE-------LLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDA-- 207
+ AL+ ++E LLAE + +E+ + S + + +++ L +G D
Sbjct: 344 ARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHV 403
Query: 208 --LGPNVDG--TSVSPGDTEP--MIRALEEKNKNFQKELSDLEEENRVLK---EKLIYLE 258
L +D T V D E ++ LEE+ + + +L EE + K E LE
Sbjct: 404 LELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVE-DLQFRVEEESITKGDLETQTKLE 462
Query: 259 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSD 318
H+ E S + + + +E S I E +K++ ALR +
Sbjct: 463 HARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDL---ALRVQEVAELR 519
Query: 319 VTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQ 378
S P A D + + + + +SS + ++ + + SL E
Sbjct: 520 RRLESNKP-AGDVD--MSLSLLQEISSLQEKLEVTRTD---------HQREITSLKEHFG 567
Query: 379 KMEENHHSTAEELQATLQELSDQQQMVQ-ELTAENEKLVDE----KTILETSFHQHRERA 433
EE H + L ++LS + + ++ +L N++ D K+ LET+ H++
Sbjct: 568 AREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAM 627
Query: 434 EQLSQENEKLMNLLQERVKNEEPTTQEGKI-IELEQKCTGILEQGRFEREKLLNIQQQLT 492
E+L K L E + E TQ K+ ++ + + + Q ER + L
Sbjct: 628 EELKVSFSK--GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALR 685
Query: 493 CSLRKVEEENQGALEMIK---------RLKEENEKLNEFLELERH--------------- 528
L KV +E + +LE I+ L E + LN+ E E
Sbjct: 686 AKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQT 745
Query: 529 ----NNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEML 584
N K EE + L+ L+ + KS ++ +Q + A E+ + E+++
Sbjct: 746 KVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ---QLEAAEKQIKHLEIEKNA 802
Query: 585 KVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTS 644
+ ++A EL EL+ L+ N + VS + +EK+ LKE
Sbjct: 803 ESSKASSITRELQGRELKLTNLQEN--LSEVSQVKETLEKELQILKE------------- 847
Query: 645 LKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLE 704
K E + E+ + + M+ET+ +L + EQ + +L L K E K + E
Sbjct: 848 -KFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE-KDERE 905
Query: 705 RQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQ 764
QL ++++ + E + D + + ND ++++ ++ KL + E + LQ
Sbjct: 906 EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQ 965
Query: 765 KELGDV 770
K + D+
Sbjct: 966 KSIEDM 971
Score = 83.2 bits (204), Expect = 9e-16
Identities = 141/626 (22%), Positives = 273/626 (43%), Gaps = 102/626 (16%)
Query: 157 ENEGGEKAALESQVRELLAEAKAKD---SEINRLRSELKKYKEKRTLNAEGTDALGPNVD 213
+N + A E ++ +L A KA SE+ +LR +L+ EK+ + E + N +
Sbjct: 749 DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEA-AEKQIKHLE----IEKNAE 803
Query: 214 GTSVSPGDTEPMIRALEEKNKNFQKELSD-------LEEENRVLKEKLIYLEHSPNSEGA 266
+ S E ++ E K N Q+ LS+ LE+E ++LKEK + E
Sbjct: 804 SSKASSITRE--LQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFA----EASEEAV 857
Query: 267 ASHTGDSSCPTSITQ-ESSFGSPTGNQMSSDIDEYKKNIHGNA--LRTSGSSSSDVTKAS 323
+ + Q E F N +SSD+++ ++N+ R + KA
Sbjct: 858 SVQRSMQETVNKLHQKEEQF-----NMLSSDLEKLRENLADMEAKFREKDEREEQLIKAK 912
Query: 324 --LSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME 381
L D ++ ++ + S+ L+ ++ + + V EL L K+ K
Sbjct: 913 EKLENDIAEIMKMSGDNSSQ-LTKMNDELRLKE--------RDVEELQL-----KLTKAN 958
Query: 382 ENHHSTAEELQATLQELSDQQQMVQELTAENE---------KLVDEKTILETSFHQHRER 432
EN A LQ ++++++ + + Q+ A+ KL D + +ETS +Q +E
Sbjct: 959 EN----ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL 1014
Query: 433 AEQLSQENEKLMNLLQERVKNEEPTT--QEGKIIELEQKCTGILEQ-----GRFEREKLL 485
+ + + +E ++N + T E K+ ++ +G+L++ + ++ K
Sbjct: 1015 KARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAA 1074
Query: 486 NIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECR--VT 543
+ + ++ +E L ++ K+ N KL L+ + NN + L + + +T
Sbjct: 1075 QTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLT 1134
Query: 544 LEGLKMEN--GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNEL 601
+E KME +++ Q QK+ + SA+++ E+ ++ E L +R E S +L
Sbjct: 1135 VENQKMEEFRKEIETLKQAAAQKSQQLSALQE--ENVKLAEELGRSRDEVT----SHQKL 1188
Query: 602 RQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQA---EQLSRTSLKLQEKASESDAEI 658
+E N + LL +++ ++K+ + +A + +S TS L EK DAE+
Sbjct: 1189 EEERSVLNNQ------LLEMKKRESKFIKDADEEKASLQKSISITSALLTEK----DAEL 1238
Query: 659 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK--- 715
+ ++ + L E A LH+ ++ LES +KLE + +LE QLK +Q+
Sbjct: 1239 EKLRNEVTVLRG--ENASAKSLHS--VVQTLESDKVKLELKVKNLELQLKENKRQLSSSS 1294
Query: 716 -------EETEEWRRFQADLQTAVVV 734
+E E + Q D +V+V
Sbjct: 1295 GNTDTQADEDERAQESQIDFLNSVIV 1320
Score = 72.4 bits (176), Expect = 2e-12
Identities = 142/699 (20%), Positives = 277/699 (39%), Gaps = 107/699 (15%)
Query: 148 RTPSTKPKQENEGGEKAAL--ESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGT 205
+T + K ++E E A + +S++ EL + + E+ LR L+ K ++ +
Sbjct: 477 KTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLS 536
Query: 206 --DALGPNVDGTSVSPGDTEPMIRALEE----KNKNFQKELS-------DLEEENRVLKE 252
+ + V+ D + I +L+E + + QKE+ L +EN LK
Sbjct: 537 LLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKS 596
Query: 253 KLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTS 312
KL EH+ S T+I ++E K + L T
Sbjct: 597 KL---EHANKENSDVIALWKSKLETAIASHQQA-----------MEELKVSF-SKGLGTE 641
Query: 313 GSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAG-SSPNSVSELSLA 371
+ +++ K + D++H ++ S + K + A E SL
Sbjct: 642 TAEFAEL-KTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLE 700
Query: 372 SLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRE 431
++ K+ K E+ H E++ TL +L + + V+EL K ++ +++ Q +
Sbjct: 701 AIRSKLDKAEDQH---LVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA 757
Query: 432 RAEQL---------SQENEKLMNLLQERVKNEEPTTQEGKIIELEQ-----KCTGILEQG 477
E+L S E + M L+++++ E ++ K +E+E+ K + I +
Sbjct: 758 TEEKLLDLDALRKASSEGKSEMKKLRQQLEAAE---KQIKHLEIEKNAESSKASSITREL 814
Query: 478 RFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEE------------NEKLNEFLEL 525
+ KL N+Q+ L+ + +V+E + L+++K E E +N+ L
Sbjct: 815 QGRELKLTNLQENLS-EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNK-LHQ 872
Query: 526 ERHNNNMMAKTLEECRVTLEGLKM---ENGSLKSHLQGEKQKATEASAVEQTAESCEVQE 582
+ NM++ LE+ R L ++ E + L K+K E E S +
Sbjct: 873 KEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL-ENDIAEIMKMSGDNSS 931
Query: 583 MLKVARAEKDLLELSCNELRQELLKANGEI----KHVSSLLAKVEKDYSYLKEICDHQAE 638
L E L E EL+ +L KAN K + + K E+ + + + +
Sbjct: 932 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK 991
Query: 639 QLSRTSLKLQEKASESDAEIKDMK----------------------ETIFELEDQVEQHR 676
+L R L++K S + +++K +T+ + ED+++ R
Sbjct: 992 ELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAR 1051
Query: 677 AVKLHNNQLISELESSVIKLEEQKS--DLERQLKTLTKQMKEETEEWRRFQADLQTAVVV 734
N+ L+ ELE + ++ K+ E ++ + + KE+TE + QT +
Sbjct: 1052 E---ENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKL 1108
Query: 735 ANDIKCEAQQELRTV------KRKLLEEEEKNARLQKEL 767
N++ + L+ V K L E +K +KE+
Sbjct: 1109 QNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEI 1147
Score = 60.1 bits (144), Expect = 8e-09
Identities = 121/591 (20%), Positives = 232/591 (39%), Gaps = 71/591 (12%)
Query: 123 RGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVREL-LAEAKAKD 181
R S+ KS K ++ + E+ E Q REL L +
Sbjct: 769 RKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENL 828
Query: 182 SEINRLRSELKK----YKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQ 237
SE+++++ L+K KEK +E ++ ++ T E L + +
Sbjct: 829 SEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLR 888
Query: 238 KELSDLE---EENRVLKEKLIYLEHSPNSEGAA--SHTGDSSCP-TSITQESSFGSPTGN 291
+ L+D+E E +E+LI + ++ A +GD+S T + E
Sbjct: 889 ENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVE 948
Query: 292 QMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFK 351
++ + K N + + L+ S + + S A E E R LS +
Sbjct: 949 ELQLKLT--KANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKEL-ERKLSDLEKKME 1005
Query: 352 SS--KCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELT 409
+S +C + + + E +Q +++ T ++L+ +E S Q ++EL
Sbjct: 1006 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1065
Query: 410 AENEKLVDEKTI---LETSFHQHRERAEQLS------QENEKLMN----LLQERVKNEEP 456
+ +K +T ++ +E+ E L+ Q N KL N L + +KN E
Sbjct: 1066 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE 1125
Query: 457 TTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEE- 515
+ +++ +E + +E+ R E E L Q + L ++EEN E + R ++E
Sbjct: 1126 LNKSKELLTVENQK---MEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1182
Query: 516 --NEKL--------NEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSH-------- 557
++KL N+ LE+++ + + EE + + + + L
Sbjct: 1183 TSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLR 1242
Query: 558 -----LQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEI 612
L+GE A +V QT ES +V+ LKV LEL E +++L ++G
Sbjct: 1243 NEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKN-----LELQLKENKRQLSSSSGNT 1297
Query: 613 KHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKE 663
+ ++D + + Q + L+ + LQ K + +++ M E
Sbjct: 1298 D------TQADED----ERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
Score = 40.0 bits (92), Expect = 0.008
Identities = 27/137 (19%), Positives = 66/137 (48%), Gaps = 3/137 (2%)
Query: 638 EQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLE 697
E L +++ +E D E ++ + + + ++ + ++Q + ELE+ + +L
Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLR 414
Query: 698 EQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQE---LRTVKRKLL 754
+R+ L Q++EE + Q ++ + D++ + + E ++ +++ LL
Sbjct: 415 TMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLL 474
Query: 755 EEEEKNARLQKELGDVQ 771
E+ K +LQ+EL D +
Sbjct: 475 FEKTKADKLQRELEDTR 491
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 100 bits (250), Expect = 4e-21
Identities = 145/680 (21%), Positives = 290/680 (42%), Gaps = 94/680 (13%)
Query: 156 QENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGT 215
Q++ + ++ + ++L + KD +I L + L+K KE +L + + L +
Sbjct: 497 QQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA- 555
Query: 216 SVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSC 275
G+T ++ L+EKN Q++++ L E+ + E H E +
Sbjct: 556 --GEGETA-VLNQLQEKNHTLQEQVTQLTEKLKNQSES-----HKQAQENLHDQVQEQKA 607
Query: 276 PTSITQESSFGSPTG-NQMSSDIDEYKKNIHGNALRTSGSS----SSDVTKASLSPDASD 330
Q+ T N+++S ++E K+ + ++ + S++ K + D +
Sbjct: 608 HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQN 667
Query: 331 FEHI-TAETPSRPLSSTSNPF-------------KSSKCSTAGSSPNSVSE--LSLASLT 374
H+ TA+ + N K CS S E LSL T
Sbjct: 668 --HLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725
Query: 375 EK----IQKMEENHHSTAEELQATLQELSDQQQMVQEL----TAENEKLVDEKTILETSF 426
E+ I+K+E + + LQ+L Q+Q+ +L T +++L EK I+ ++
Sbjct: 726 EELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTR 785
Query: 427 HQHRERAEQLSQENEKLMNLLQERV---KNEEPTTQEGKIIELE-----QKCTGILEQGR 478
++++E L +KL +E+ ++ E +QE KI E Q L++ +
Sbjct: 786 LDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVK 845
Query: 479 FERE-----------KLLNIQQQLTCSLRKVEEENQ----GALEMIKRLKEENEKLNEFL 523
E+E KL + L S + E+ENQ L++ K KE +L +
Sbjct: 846 MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQM 905
Query: 524 ELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHL--------QGEKQKATEASAVEQTA 575
E + K+LE+ + LK+E S++ L Q EK++ + +
Sbjct: 906 ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK 965
Query: 576 ESCE--------VQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYS 627
+S E +Q LK+A +K LE N+L+Q+L +A E+ ++ ++ +Y
Sbjct: 966 QSSEQKKKQIEALQGELKIAVLQKTELE---NKLQQQLTQAAQELAAEKEKISVLQNNYE 1022
Query: 628 YLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLIS 687
+E +QL + + + ++K ++E + ++ + +R + N+LI
Sbjct: 1023 KSQETF----KQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1078
Query: 688 ELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADL---QTAVVVANDIKCEAQQ 744
EL+++ LE+ + E+QL+ K +++ +E + +L ++ + +IKC ++
Sbjct: 1079 ELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEK 1138
Query: 745 ELRTVKRKLLEEEEKNARLQ 764
E+ L EE K+ +L+
Sbjct: 1139 EITK-----LNEELKSHKLE 1153
Score = 93.2 bits (230), Expect = 8e-19
Identities = 135/618 (21%), Positives = 268/618 (43%), Gaps = 83/618 (13%)
Query: 168 SQVRELLAEAKAKDSEI-NRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMI 226
S++ E L E +E+ ++L ++++E++ L T L + D E ++
Sbjct: 463 SRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE-------AQNDLEQVL 515
Query: 227 RALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFG 286
R + +K++ Q +LE + KE + LE A G+ T++ +
Sbjct: 516 RQIGDKDQKIQ----NLEALLQKSKENISLLEKEREDLYAKIQAGEGE--TAVLNQLQEK 569
Query: 287 SPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSST 346
+ T + + + E KN + + + V + A+ ++ ET L+S
Sbjct: 570 NHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQ 629
Query: 347 SNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEE--NHHSTAEE-LQATLQELSDQQQ 403
N K K S + +EL L++ K + + NH TA+ LQ QEL+
Sbjct: 630 LNESKE-KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITT 688
Query: 404 MVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQ--ERVKNEEPTTQEG 461
+ ++TA+ + + + LE+ +++E+ L Q+ E+L ++ E E ++E
Sbjct: 689 QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ 748
Query: 462 KIIELEQK--CTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKR-------- 511
+ +L+Q+ LE E K L +++++ S R ++ ALE IK+
Sbjct: 749 ALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEE 808
Query: 512 ---LKEENEKLNEFLELERHN-NNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATE 567
LK++ E L++ +++ NN + T+ E L+ +KME +L + L K K ++
Sbjct: 809 KQILKQDFETLSQETKIQHEELNNRIQTTVTE----LQKVKMEKEALMTELSTVKDKLSK 864
Query: 568 ASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQEL-LKANGEIKHVSSLLAKVEKDY 626
S + ++S +E K A DL E +C EL+ +L ++ +K L +EK+
Sbjct: 865 VSDSLKNSKSEFEKENQKGKAAILDL-EKTCKELKHQLQVQMENTLKEQKELKKSLEKE- 922
Query: 627 SYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLI 686
+E + + E+ M+E + + ++ ++Q+
Sbjct: 923 ---------------------KEASHQLKLELNSMQEQLIQAQNTLKQNE---------- 951
Query: 687 SELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQEL 746
K E+Q +LK ++Q K++ E Q +L+ AV+ +++ + QQ+L
Sbjct: 952 --------KEEQQLQGNINELKQSSEQKKKQIEA---LQGELKIAVLQKTELENKLQQQL 1000
Query: 747 RTVKRKLLEEEEKNARLQ 764
++L E+EK + LQ
Sbjct: 1001 TQAAQELAAEKEKISVLQ 1018
Score = 85.1 bits (209), Expect = 2e-16
Identities = 147/683 (21%), Positives = 286/683 (41%), Gaps = 84/683 (12%)
Query: 145 KHLRTPSTKPKQENEGGEK---------AALESQVRELLAEAKAKDSEINRLRSELKKYK 195
KH GGE L +V++L A K + L+ EL+KY+
Sbjct: 58 KHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQ 117
Query: 196 EKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRV-LKEKL 254
+ A+ D L V +S E + + +N N K++ DL E+ L ++
Sbjct: 118 GLQQQEAK-PDGL---VTDSSAELQSLEQQLEEAQTENFNI-KQMKDLFEQKAAQLATEI 172
Query: 255 IYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGS 314
++ + E + + T +T+E N+ ++ I + K + L+ G
Sbjct: 173 ADIKSKYDEERSLREAAEQKV-TRLTEEL-------NKEATVIQDLKTEL----LQRPGI 220
Query: 315 SSSDVTKASLSPDASDFEHITAETP--SRPLSSTSNPFKSSKCSTAGSSPNSVSELS--- 369
V K L + +++T E S L +S S+ + SEL+
Sbjct: 221 EDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGP 280
Query: 370 --LASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAE-NEKLVDEKTILETSF 426
+A +++QK++ + + ++ Q + L ++Q +L + NE+ V +K I + +
Sbjct: 281 QEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNI-QATL 339
Query: 427 HQHRERAEQLSQE---NEKLMNLLQERVKNEEPTTQEGK--IIELEQKCTGI------LE 475
HQ +QL +E ++ + + + TQ+ K + E+E K + L+
Sbjct: 340 HQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQ 399
Query: 476 QGRFEREKL-LNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMA 534
Q R E+E+ L +Q ++ K+ E + E RLKE+ + +E L + +
Sbjct: 400 QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQ 459
Query: 535 KTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLL 594
L L+ + L+ L KQ+ E A++Q+ + K+ A+ DL
Sbjct: 460 LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTA-------KLREAQNDL- 511
Query: 595 ELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYL-KEICDHQAE------------QLS 641
++ +++ + +I+++ +LL K +++ S L KE D A+ QL
Sbjct: 512 ----EQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQ 567
Query: 642 RTSLKLQEKASESDAEIKDMKETIFE----LEDQVEQHRAVKLHNNQLISELESSVIKLE 697
+ LQE+ ++ ++K+ E+ + L DQV++ +A + LE+SV +L
Sbjct: 568 EKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELN 627
Query: 698 EQKSDLERQLKTLTKQMKEETEEWRRFQA-------DLQTAVVVANDIKCEAQQELRTVK 750
Q ++ + ++ L Q+K +TE +A DLQ + A + + QQEL +
Sbjct: 628 SQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKIT 687
Query: 751 RKLLEEEEKNARLQKELGDVQGH 773
+L + K Q+ ++ H
Sbjct: 688 TQLDQVTAKLQDKQEHCSQLESH 710
Score = 82.8 bits (203), Expect = 1e-15
Identities = 143/660 (21%), Positives = 270/660 (40%), Gaps = 84/660 (12%)
Query: 146 HLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGT 205
HL T + + + E + +Q+ ++ A+ + K ++L S LK+YKEK + T
Sbjct: 668 HLDTAQNALQDKQQ--ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725
Query: 206 DALGPNV-----DGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHS 260
+ L + D V + + +++ N EL E ++ EK I
Sbjct: 726 EELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV---- 781
Query: 261 PNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNI---HGNALRTSGSSSS 317
S S SI Q+ + + D + + H ++ +
Sbjct: 782 --SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVT 839
Query: 318 DVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKC-----STAGSSPNSVSELSLAS 372
++ K + +A E T + LS S+ K+SK + G + E +
Sbjct: 840 ELQKVKMEKEALMTELSTVKDK---LSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKE 896
Query: 373 LTEKIQKMEENHHSTAEELQATLQ-ELSDQQQMVQELTAENEKLVDEKTILETSFHQHRE 431
L ++Q EN +EL+ +L+ E Q+ EL + E+L+ + L+ + + ++
Sbjct: 897 LKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956
Query: 432 ------RAEQLSQENEKLMNLLQERVKNE--EPTTQEGKIIELEQKCTGILEQGRFEREK 483
+Q S++ +K + LQ +K + T E K L+Q+ T ++ E+EK
Sbjct: 957 LQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK---LQQQLTQAAQELAAEKEK 1013
Query: 484 LLNIQ----------QQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMM 533
+ +Q +QL E E + +K ++E+ E L R+
Sbjct: 1014 ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ 1073
Query: 534 AKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCE-VQEMLKVARAEKD 592
K ++E + L+ ++ + LQ E+ KA + E++ + E V E K+A E
Sbjct: 1074 NKLIQELKTAKATLEQDSAKKEQQLQ-ERCKALQDIQKEKSLKEKELVNEKSKLAEIE-- 1130
Query: 593 LLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKAS 652
E+ C + +E+ K N E+K S L + K+ + LK+ + L + L+LQ KA
Sbjct: 1131 --EIKCRQ-EKEITKLNEELK--SHKLESI-KEITNLKDA----KQLLIQQKLELQGKAD 1180
Query: 653 ESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTK 712
A ++ K L+DQV++ EL+ I E+++ L ++K
Sbjct: 1181 SLKAAVEQEKRNQQILKDQVKKEE----------EELKKEFI---EKEAKLHSEIKEKEV 1227
Query: 713 QMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQG 772
MK+ E +A L + N+ L TVK++ + + + L+K+ D++G
Sbjct: 1228 GMKKHEEN----EAKLTMQITALNE-------NLGTVKKEWQSSQRRVSELEKQTDDLRG 1276
Score = 75.1 bits (183), Expect = 2e-13
Identities = 121/635 (19%), Positives = 259/635 (40%), Gaps = 60/635 (9%)
Query: 159 EGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVS 218
E EK +++E L+E + K L++E K+ +++R + L ++
Sbjct: 366 ELSEKGEATQKLKEELSEVETK---YQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
Query: 219 PGDTEPMIRA----LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAAS----HT 270
+TE + L+E+ + ++L D E++ L+ KL LE + S H
Sbjct: 423 LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482
Query: 271 GDSSCPTSITQESSFGSPTGN--QMSSDIDEYKKNIHGNALRTSGSSSSDVT--KASLSP 326
D + Q++ S T + +D+++ LR G + +A L
Sbjct: 483 LDKTKQQHQEQQALQQSTTAKLREAQNDLEQ--------VLRQIGDKDQKIQNLEALLQK 534
Query: 327 DASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHS 386
+ + E + +++ + +++ E + LTEK++ E+H
Sbjct: 535 SKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQE-QVTQLTEKLKNQSESHKQ 593
Query: 387 TAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNL 446
E L +QE + Q+ E V+E L + ++ +E+ QL + + L
Sbjct: 594 AQENLHDQVQEQKAHLRAAQDRVLSLETSVNE---LNSQLNESKEKVSQLDIQIKAKTEL 650
Query: 447 LQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGAL 506
L T Q + L+ + E K+ Q+T K++++ +
Sbjct: 651 LLSA--EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA---KLQDKQEHCS 705
Query: 507 EMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKAT 566
++ LKE EK +L LE+ + + + +LE +K LQ ++Q T
Sbjct: 706 QLESHLKEYKEK---YLSLEQKTEELEGQIKKLEADSLE-VKASKEQALQDLQQQRQLNT 761
Query: 567 EASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDY 626
+ E+ K EK+++ + R +L K + ++ + L K E++
Sbjct: 762 DLEL--------RATELSKQLEMEKEIV----SSTRLDLQKKSEALESIKQKLTKQEEE- 808
Query: 627 SYLKEICDHQAEQLSR-TSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQL 685
K+I E LS+ T ++ +E + + ++++ E E + + VK +++
Sbjct: 809 ---KQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKV 865
Query: 686 ISELESSVIKLEEQKS-------DLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDI 738
L++S + E++ DLE+ K L Q++ + E + Q +L+ ++ +
Sbjct: 866 SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEA 925
Query: 739 KCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGH 773
+ + EL +++ +L++ + + +KE +QG+
Sbjct: 926 SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
Score = 53.1 bits (126), Expect = 1e-06
Identities = 99/523 (18%), Positives = 215/523 (41%), Gaps = 69/523 (13%)
Query: 147 LRTPSTKPKQENEGGEKAAL--ESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEG 204
L+ ++ ++EN+ G+ A L E +EL + + + + + ELKK EK E
Sbjct: 869 LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEK---EA 925
Query: 205 TDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSE 264
+ L ++ + ++ E++ + Q +++L++ + K+++ L+
Sbjct: 926 SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIA 985
Query: 265 GAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDV--TKA 322
++ +TQ + + ++S + Y+K+ T SD ++
Sbjct: 986 VLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKS-----QETFKQLQSDFYGRES 1040
Query: 323 SLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEE 382
L D + + + LS S++ + G+ + EL A T +E+
Sbjct: 1041 ELLATRQDLKSVEEK-----LSLAQEDLISNR-NQIGNQNKLIQELKTAKAT-----LEQ 1089
Query: 383 NHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEK 442
+ ++LQ + L D Q+ E + + ++LV+EK+ L E++ EK
Sbjct: 1090 DSAKKEQQLQERCKALQDIQK---EKSLKEKELVNEKSKL--------AEIEEIKCRQEK 1138
Query: 443 LMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEEN 502
+ L E +K+ + +E ++ T + + + ++ L +Q + VE+E
Sbjct: 1139 EITKLNEELKSHK--------LESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEK 1190
Query: 503 QGALEMIKRLKEENEKL-NEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGE 561
+ + ++K+E E+L EF+E E AK E +K + +K H + E
Sbjct: 1191 RNQQILKDQVKKEEEELKKEFIEKE-------AKLHSE-------IKEKEVGMKKHEENE 1236
Query: 562 KQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAK 621
+ + +A + E L + E + +EL ++ GEI + + +
Sbjct: 1237 AKLTMQITA---------LNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQN 1287
Query: 622 VEKDYSYLKEIC---DHQAEQLSRTSLKLQEKASESDAEIKDM 661
+ + L E C + + E+L L+LQ K + A ++++
Sbjct: 1288 NQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQEL 1330
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 98.6 bits (244), Expect = 2e-20
Identities = 144/644 (22%), Positives = 263/644 (40%), Gaps = 91/644 (14%)
Query: 160 GGEKAALESQVREL---------LAEAKAKDSEINR--LRSELKKYKEKRTLNAEGTDAL 208
GGE A V+E LAE++A+ + + L+++L++ + L + L
Sbjct: 325 GGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKD---L 381
Query: 209 GPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAAS 268
+ + D + L K +K+ + ++ N+ L EKL LE E AA
Sbjct: 382 AQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAAL 441
Query: 269 HTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSS-SSDVTKASLSPD 327
T D Q D+ + + + ++ SGS ++D + SL
Sbjct: 442 ETEDGEGL--------------QQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGL 487
Query: 328 ASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHST 387
+ TPS P S+ +S + G SP +LA + HS
Sbjct: 488 SGQ------RTPSPPRRSSPGRGRSPR---RGPSPACSDSSTLALI-----------HSA 527
Query: 388 AEELQATLQELSDQQQMVQELTAENEKLVD----EKTILETSFHQHRERAEQLSQENEKL 443
+ Q +Q++ + + Q+L K + E+ LE + R++ + Q +E
Sbjct: 528 LHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDA 587
Query: 444 MNLLQE-RVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEEN 502
+Q R NE + ++ + Q E+ R EREKL Q++L ++EEE
Sbjct: 588 QREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQ 647
Query: 503 QGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEK 562
+ A++ R++ E E+ + LE +++AK L E R L ++ L+
Sbjct: 648 EDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ------- 700
Query: 563 QKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKV 622
AE EV E L A A + LELS +LR E + +S+L +
Sbjct: 701 ------------AEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESL 748
Query: 623 EKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHN 682
+D L + E+ +++L+ +++ +E +A + + EQ R +L
Sbjct: 749 AQDKLDLNRLVAQLEEE--KSALQGRQRQAEQEATVA-----------REEQERLEELRL 795
Query: 683 NQLISE--LESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKC 740
Q ++ LE S+ E+ + LE+QL TL + + E+ + L +
Sbjct: 796 EQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARR 855
Query: 741 EAQQELRTVKRKLLEEE---EKNARLQKELGDVQGHGRVVTSRA 781
EAQ+++ ++R E+E +++A L +L + GR ++ A
Sbjct: 856 EAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEA 899
Score = 77.4 bits (189), Expect = 5e-14
Identities = 100/454 (22%), Positives = 195/454 (42%), Gaps = 63/454 (13%)
Query: 375 EKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 434
E +++ + A+E +L ++ + L+ E +L EK LE S + + +
Sbjct: 862 EALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLA 921
Query: 435 QLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFERE----KLLNIQQQ 490
QL E+L Q + +E T G++ L Q+ E+ ++E KL+ +++
Sbjct: 922 QLEARREQLEAEGQALLLAKETLT--GELAGLRQQIIATQEKASLDKELMAQKLVQAERE 979
Query: 491 LTCSLRKVEEENQGALEMIKRLKE------ENEKLNEFLELERHNNNMMAKT---LEECR 541
SLR+ ++ L+ ++R KE E E+ +L+R ++A+ EE
Sbjct: 980 AQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELS 1039
Query: 542 VTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAES--------------CEVQEMLKVA 587
+ L+ E + EKQ+A E+TA S E++ + A
Sbjct: 1040 EEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDA 1099
Query: 588 RAEKDLLELSCNELRQEL--LKANGE---IKHVSSL--LAKVEKDYSYLKEICDHQAEQL 640
++ ++ + N L EL L+A E H + L + +D ++ C +AE+L
Sbjct: 1100 QSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEEL 1159
Query: 641 SRTSLKLQEKASES-------------------DAEIKDMKETIFELEDQVEQHRAVKLH 681
RT L+L E A + + + ++ E L + ++ A++
Sbjct: 1160 -RTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRS 1218
Query: 682 NNQL---ISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDI 738
N +L + + ES I L+ D E++L L + +E +L+T +
Sbjct: 1219 NEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKE----AGELRTGLQEVERS 1274
Query: 739 KCEAQQELRTVKRKLLEEEEKNARLQKELGDVQG 772
+ EA++EL+ ++R++ + +N RL +EL ++QG
Sbjct: 1275 RLEARRELQELRRQMKMLDSENTRLGRELAELQG 1308
Score = 70.1 bits (170), Expect = 8e-12
Identities = 101/495 (20%), Positives = 195/495 (39%), Gaps = 68/495 (13%)
Query: 332 EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEE- 390
E +A + +R L + ++ S G +EL+L E +++ E +T ++
Sbjct: 1545 ERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQE--ESVRRSERERRATLDQV 1602
Query: 391 ------LQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLM 444
LQAT EL Q+ + ++ A KL +K L+ R +L + L
Sbjct: 1603 ATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLE 1662
Query: 445 NLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQ---QQLTCSLRKVEEE 501
LQ + +E + L+ + + Q K +Q ++L +L KVEE
Sbjct: 1663 GELQR--SRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEES 1720
Query: 502 NQGALEMIKRLKE--------------ENEKLNEFLELERHNNNMMAKTLEECRVTLEGL 547
+ ++ L E +N L + L H+ ++ + L+ R L
Sbjct: 1721 EGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEA 1780
Query: 548 KMENGSLKSHLQ-----------------GEKQKATEASAVEQTAESCEVQEMLKVARAE 590
+ ++ SL +Q G+ Q+ E Q E+ + + K+ + E
Sbjct: 1781 RKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKL-QDE 1839
Query: 591 KDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEK 650
+ LL+ L++ L + E + V ++EKD L+ D ++ R L+ E
Sbjct: 1840 RRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLD----KVEREKLRSHED 1895
Query: 651 ASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTL 710
AE + T+ E ++ + + + I +LE+ V+ LE+ S + ++
Sbjct: 1896 TVRLSAEKGRLDRTLTGAELELAEAQ-------RQIQQLEAQVVVLEQSHSPAQLEVDAQ 1948
Query: 711 TKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDV 770
+Q++ + E R A QT + EA++ + + LEE+ + G +
Sbjct: 1949 QQQLELQQEVERLRSAQAQT------ERTLEARERAHRQRVRGLEEQVSTLK-----GQL 1997
Query: 771 QGHGRVVTSRAAPPS 785
Q R ++ +PPS
Sbjct: 1998 QQELRRSSAPFSPPS 2012
Score = 69.3 bits (168), Expect = 1e-11
Identities = 143/729 (19%), Positives = 276/729 (37%), Gaps = 85/729 (11%)
Query: 117 RERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAE 176
R S R PS PR+S S P+ ST + ++ + QV+++
Sbjct: 485 RGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKR---QLQVQDMRGR 541
Query: 177 AKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNF 236
+A + LR +L + +R E L DG + D + ++ L N+
Sbjct: 542 YEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELL 601
Query: 237 QKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSD 296
+E S+L +V +++ L AA + +E G ++ +
Sbjct: 602 SREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQ-RDRLEEEQEDAVQDGARVRRE 660
Query: 297 ID---------EYKKNIHGNAL------RTSGSSSSDVTKASLSPDASDFEHITAETPSR 341
++ E K+++ L + + D+ +A + A A
Sbjct: 661 LERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVEL 720
Query: 342 PLSSTSNPFKSSKCSTAGSSPNSVSE------LSLASLTEKI----------QKMEENHH 385
LS T + + + S ++++E L L L ++ Q+ E
Sbjct: 721 ELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEA 780
Query: 386 STAEELQATLQELSDQQQMVQELTAENEKLVDE-KTILETSFHQHRERAEQLSQENEKLM 444
+ A E Q L+EL +Q++ ++ + ++ ++ + LE R QL ++ +L
Sbjct: 781 TVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLS 840
Query: 445 NLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQG 504
L R + E +E Q+ LE+ E+E L L L E E +
Sbjct: 841 RQLSGREQELEQARREA------QRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRT 894
Query: 505 ALEMIKRLKEENEKL-NEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQ 563
E RL+ E E L E++R + A+ E+ + L + +L L G +Q
Sbjct: 895 LSEEATRLRLEKEALEGSLFEVQRQLAQLEARR-EQLEAEGQALLLAKETLTGELAGLRQ 953
Query: 564 KA----------TEASAVEQTAESCEVQEMLKVARA--EKDL------LELSCNELRQEL 605
+ E A + E Q L+ RA E+DL E + EL E
Sbjct: 954 QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013
Query: 606 LKANGEI-KHVSSLLAKVEKDYSYLKE------------ICDHQAEQLSRTSLKLQEKAS 652
+ ++ + LLA++E + L E + ++E+ SLK EK +
Sbjct: 1014 AQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTA 1073
Query: 653 ESDAEI---KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLE----- 704
S+ + + E+E Q ++ + + ++ L S + L Q+ +
Sbjct: 1074 LSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQ 1133
Query: 705 --RQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNAR 762
R+L+ + + ++ + R +L+T + + D + ++EL +RKL E +E
Sbjct: 1134 EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREV 1193
Query: 763 LQKELGDVQ 771
++E G+++
Sbjct: 1194 QRQEAGELR 1202
Score = 65.5 bits (158), Expect = 2e-10
Identities = 128/650 (19%), Positives = 248/650 (38%), Gaps = 63/650 (9%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 221
E++ L+ Q+ +L + ++ E+ + R E ++ E A +AL G +V
Sbjct: 828 ERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVA 887
Query: 222 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLE---HSPNSEGAASHTGDSSCPTS 278
E R L E+ + E LE ++ +L LE +EG A
Sbjct: 888 AEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQA---------LL 938
Query: 279 ITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAET 338
+ +E+ G G + + K ++ + + +ASL + E +
Sbjct: 939 LAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEE-DLQR 997
Query: 339 PSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQEL 398
R + ++ + EL EK + EE E + L
Sbjct: 998 LQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE 1057
Query: 399 SDQQQMVQ----ELTAENEKLVDEKTILET-SFHQHRER--AEQLSQENEKLMNLLQERV 451
S++QQ + E TA +EKL+ + L T S R++ A+ +++ +N L +
Sbjct: 1058 SEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSEL 1117
Query: 452 KNEEPTTQEGKIIELEQKCTGILEQGRF---EREKLLNIQQQLTCSLRKVEEENQGALEM 508
++ +E Q+ + EQ R +R+ L ++L LR +E+ G
Sbjct: 1118 RDLRAQREEAAAAHA-QEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRE 1176
Query: 509 IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEA 568
+ + + + E E++R + ++L E E L+ N L+S ++
Sbjct: 1177 LLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVK--------- 1227
Query: 569 SAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSY 628
AES + LK+A +K+ E R + K GE++ +
Sbjct: 1228 -----KAESERIS--LKLANEDKEQKLALLEEARTAVGKEAGELR-------------TG 1267
Query: 629 LKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISE 688
L+E+ + + R +L+ + D+E + + EL+ ++ + + +
Sbjct: 1268 LQEV-ERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLG 1326
Query: 689 LESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRT 748
L ++K E + ++L+ ++++E+ E+R + L ++ A + + R
Sbjct: 1327 LRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARG 1386
Query: 749 VKRKL----LEEEEKNARLQKELGDVQG----HGRV-VTSRAAPPSLGSV 789
++ KL E E RL G QG RV V RAA LG +
Sbjct: 1387 LELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGL 1436
Score = 41.2 bits (95), Expect = 0.004
Identities = 40/200 (20%), Positives = 91/200 (45%), Gaps = 6/200 (3%)
Query: 579 EVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAE 638
E + L+ A+ E+D L + L ++L + E +S +++K + +E
Sbjct: 1513 EFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDG 1572
Query: 639 QLSRTSLKL---QEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIK 695
+LS +L +E S+ E + + + LE ++ + + + IS+++++ K
Sbjct: 1573 RLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETK 1632
Query: 696 LEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEA---QQELRTVKRK 752
LE K L+ L + + + R + +LQ + + +D + +A Q + +++R+
Sbjct: 1633 LEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQ 1692
Query: 753 LLEEEEKNARLQKELGDVQG 772
+ + E K LQ + + G
Sbjct: 1693 VADSEVKAGTLQLTVERLNG 1712
Score = 37.7 bits (86), Expect = 0.042
Identities = 51/282 (18%), Positives = 112/282 (39%), Gaps = 32/282 (11%)
Query: 446 LLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGA 505
L QE+ Q+ +I L I+ + + E + + SL ++EENQ
Sbjct: 27 LCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPESPVLLPATEMASLLSLQEENQ-- 84
Query: 506 LEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLE-GLKMENGSLKSHLQGEKQK 564
L++E ++ + L R + +A LE L++E G L++
Sbjct: 85 -----LLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQ------- 132
Query: 565 ATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEK 624
E + + +S E++ L+ +A R++L + + L+ +++
Sbjct: 133 --EPRGLVR--QSVELRRQLQEEQAS----------YRRKLQAYQEGQQRQAQLVQRLQG 178
Query: 625 DYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQ 684
K+ C +QL S +L+++ +D++ + LE++ ++ ++ N
Sbjct: 179 KILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAM 238
Query: 685 LISELESSVIKLEEQKSDLERQLKTLT---KQMKEETEEWRR 723
L +L+ + + D+ + T K+++ WRR
Sbjct: 239 LREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRR 280
Score = 35.8 bits (81), Expect = 0.16
Identities = 30/158 (18%), Positives = 74/158 (46%), Gaps = 26/158 (16%)
Query: 576 ESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDH 635
E V+++L +RAE+D L + N + + L +A ++E E+
Sbjct: 89 ELSRVEDLLAQSRAERDELAIKYNAVSERLEQA-----------LRLEPG-----ELETQ 132
Query: 636 QAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIK 695
+ L R S++L+ + E A + +++ ++ + QL+ L+ +++
Sbjct: 133 EPRGLVRQSVELRRQLQEEQASYRR----------KLQAYQEGQQRQAQLVQRLQGKILQ 182
Query: 696 LEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVV 733
+++ S+LE+QL + +++++ DL++A++
Sbjct: 183 YKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI 220
Score = 34.3 bits (77), Expect = 0.46
Identities = 25/90 (27%), Positives = 44/90 (48%), Gaps = 7/90 (7%)
Query: 165 ALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEP 224
+L+ QV + +A + RL L K +E +EG AL V G + + +
Sbjct: 1688 SLQRQVADSEVKAGTLQLTVERLNGALAKVEE-----SEG--ALRDKVRGLTEALAQSSA 1740
Query: 225 MIRALEEKNKNFQKELSDLEEENRVLKEKL 254
+ + +KN + QK L+ E + +VL+E+L
Sbjct: 1741 SLNSTRDKNLHLQKALTACEHDRQVLQERL 1770
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 96.3 bits (238), Expect = 1e-19
Identities = 135/613 (22%), Positives = 249/613 (40%), Gaps = 95/613 (15%)
Query: 221 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN-------SEGAASHTGDS 273
+TE + ++E+ + + EL+ E + + L+EK++ L N SE + +
Sbjct: 847 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEE 906
Query: 274 SCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEH 333
C I + + ++ + ++ NA T+ + + L D D E
Sbjct: 907 RCEQLIKNKIQLEA----KIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLEL 962
Query: 334 ITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQA 393
A+ + K +T N E +A L E I K+ + + E Q
Sbjct: 963 TLAKV------------EKEKHATENKVKNLTEE--MAGLDETIAKLSKEKKALQETHQQ 1008
Query: 394 TLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL---MNLLQER 450
TL +L ++ V LT KL + LE S Q ++ L + KL + L QE
Sbjct: 1009 TLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1068
Query: 451 VKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIK 510
+ E Q +L++K LE+ FE L++ K+E+E +++ K
Sbjct: 1069 TMDMENDKQ-----QLDEK----LEKKEFEISNLIS----------KIEDEQAVEIQLQK 1109
Query: 511 RLKE---ENEKLNEFLELER-------HNNNMMAKTLEECRVTLEGLKMENGSLKSHLQG 560
++KE E+L E +E ER + +++ LEE E L+ G+ + ++
Sbjct: 1110 KIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEIS---ERLEEAGGATSAQVEL 1166
Query: 561 EKQKATEASAVEQTAESCEVQEMLKVARAEK----DLLEL-----SCNELRQELLKANGE 611
K++ E + + E +Q VA K + EL + ++Q+L K E
Sbjct: 1167 NKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSE 1226
Query: 612 IK----HVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFE 667
+K +SS + K L+++C +Q+S +L+ K E I D+
Sbjct: 1227 LKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVS----ELKTKEEEQQRLINDLTAQRAR 1282
Query: 668 LEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ-------------- 713
L+ + ++ + L+S+L S +Q +L+ QL+ TK
Sbjct: 1283 LQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHD 1342
Query: 714 ---MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEE-EEKNARLQKELGD 769
++E+ EE + +A+LQ A+ AN + + + T + EE EE +L + L +
Sbjct: 1343 CDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE 1402
Query: 770 VQGHGRVVTSRAA 782
+ H V ++ A
Sbjct: 1403 AEEHVEAVNAKCA 1415
Score = 80.9 bits (198), Expect = 4e-15
Identities = 134/632 (21%), Positives = 248/632 (39%), Gaps = 51/632 (8%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 221
EK A E++V+ L E D I +L E K +E + A V+ + +
Sbjct: 970 EKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTK 1029
Query: 222 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQ 281
E + LE + +K DLE R L+ L + S D +
Sbjct: 1030 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFE 1089
Query: 282 ESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSR 341
S+ S ++ + +I KK A + +AS + + SR
Sbjct: 1090 ISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDL-----SR 1144
Query: 342 PLSSTSNPFKSSKCSTAGSSP-NSVSELSLASLTEKIQKMEENHHSTAEELQAT-LQELS 399
L S + + +T+ N E L +++ H + L+ ++
Sbjct: 1145 ELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMA 1204
Query: 400 DQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQEN---EKLMNLLQERVKNEEP 456
+ + + L +KL EK+ L+ AE +S+ EK+ L+++V +
Sbjct: 1205 ELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKT 1264
Query: 457 TTQEGKIIELE---QKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLK 513
+E + + + Q+ E G + R+ L+ + L L + ++ + +E +K
Sbjct: 1265 KEEEQQRLINDLTAQRARLQTEAGEYSRQ--LDEKDALVSQLSRSKQASTQQIEELKHQL 1322
Query: 514 EENEK----LNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEAS 569
EE K L L+ RH+ +++ + EE + EG K+ LQ KA
Sbjct: 1323 EEETKAKNALAHALQSSRHDCDLLREQYEEEQ---EG--------KAELQRALSKANSEV 1371
Query: 570 AVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYL 629
A +T + + R E+ LE + +L Q L +A ++ V++ A +EK L
Sbjct: 1372 AQWRTKYETDA-----IQRTEE--LEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRL 1424
Query: 630 KEICDH---QAEQLSRTSLKLQEKASESDAEIKDMK----ETIFELEDQVEQHRAVKLHN 682
+ + E+ + L +K D + + K ET ELE ++ R++
Sbjct: 1425 QNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTEL 1484
Query: 683 NQLISELESSVIKLE---EQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIK 739
++ + E S+ +LE + +L++++ LT+Q+ E ++ +L+ K
Sbjct: 1485 FKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIH----ELEKIKKQVEQEK 1540
Query: 740 CEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 771
CE Q L + L EE K R+Q EL V+
Sbjct: 1541 CEIQAALEEAEASLEHEEGKILRIQLELNQVK 1572
Score = 73.9 bits (180), Expect = 5e-13
Identities = 87/432 (20%), Positives = 177/432 (40%), Gaps = 62/432 (14%)
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 435
K + E+ + EE Q T EL+ + +EL + L+ EK L+ +
Sbjct: 844 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLAD 903
Query: 436 LSQENEKLM-NLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCS 494
+ E+L+ N +Q K +E T + + E+ + T + E +L L +
Sbjct: 904 AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELT 963
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 554
L KVE+E +K L EE L+E + + +T ++ TL+ L+ E +
Sbjct: 964 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQ---TLDDLQAEEDKV 1020
Query: 555 KSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKH 614
K K V+ S E ++ L++ +L + K G++K
Sbjct: 1021 NILT---KAKTKLEQQVDDLEGSLEQEKKLRM-------------DLERAKRKLEGDLKL 1064
Query: 615 VSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKAS---ESDAEIKDMKETIFELEDQ 671
+E D L E + + ++S K++++ + + +IK+++ I EL ++
Sbjct: 1065 AQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEE 1124
Query: 672 VEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQM--------------KEE 717
+E RA S K E+Q+SDL R+L+ +++++ K+
Sbjct: 1125 IEAERA--------------SRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKR 1170
Query: 718 TEEWRRFQADLQTAVVVAN-----------DIKCEAQQELRTVKRKLLEEEEKNARLQKE 766
E+++ + DL+ A + D E +++ ++R + E++ + L+ E
Sbjct: 1171 EAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKME 1230
Query: 767 LGDVQGHGRVVT 778
D+ + ++
Sbjct: 1231 TDDLSSNAEAIS 1242
Score = 73.9 bits (180), Expect = 5e-13
Identities = 152/674 (22%), Positives = 278/674 (41%), Gaps = 102/674 (15%)
Query: 165 ALESQVRELLAEAKAKDSEINRL---RSELKKYKEKRTLNAEGTDALGPNVDGTS-VSPG 220
+LE QV EL + + + IN L R+ L+ + + + DAL + + S
Sbjct: 1254 SLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQ 1313
Query: 221 DTEPMIRALEEKNKN-------FQKELSDLE------EENRVLKEKLIYLEHSPNSEGAA 267
E + LEE+ K Q D + EE + K +L NSE A
Sbjct: 1314 QIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQ 1373
Query: 268 SHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNAL---RTSGSSSSDVTKASL 324
T + T+E Q + +E+ + ++ +T ++V L
Sbjct: 1374 WRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1433
Query: 325 SPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENH 384
+ S+ + R + +K T S E SL+ ++ K++ +
Sbjct: 1434 DVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESR--SLSTELFKVKNVY 1491
Query: 385 HSTAEELQATLQELSDQQQMVQELT---AENEKLVDEKTILETSFHQHRERAEQLSQENE 441
+ ++L+ +E + QQ + +LT AE K + H+ + +Q+ QE
Sbjct: 1492 EESLDQLETLRRENKNLQQEISDLTEQIAEGGKQI----------HELEKIKKQVEQEKC 1541
Query: 442 KLMNLLQERVKNEEPTTQEGKIIELEQKCTGIL-EQGRFEREKLLNIQQQLTCSLRKVEE 500
++ L+E + E +EGKI+ ++ + + E R EK I Q R VE
Sbjct: 1542 EIQAALEEAEASLEH--EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVET 1599
Query: 501 -------ENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGS 553
E + + ++ K+ LNE H N + A++L R T LK
Sbjct: 1600 MQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLH 1659
Query: 554 LKSHLQGEKQKATEASAVEQTAE--SCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 611
L L+G++ + + VE+ A E++E+ A + E S QELL A+
Sbjct: 1660 LDDALRGQEDLKEQLAIVERRANLLQAEIEELW----ATLEQTERSRKIAEQELLDASER 1715
Query: 612 IKHV----SSLL---AKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASE--SDAEI---- 658
++ + +SL+ K+E D S L+ + E++ + S +EKA + +DA +
Sbjct: 1716 VQLLHTQNTSLINTKKKLENDVSQLQS----EVEEVIQESRNAEEKAKKAITDAAMMAEE 1771
Query: 659 ---------------KDMKETIFELEDQVEQHRAVKLH-NNQLISELESSVIKLE----- 697
K++++T+ +L+ ++++ + L + I +LE+ V +LE
Sbjct: 1772 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVEN 1831
Query: 698 EQKSDLE-----RQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRK 752
EQK + E R+ + K++ +TEE R+ LQ D+ + Q ++++ KR+
Sbjct: 1832 EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQ-------DLVDKLQAKVKSYKRQ 1884
Query: 753 LLE-EEEKNARLQK 765
E EE+ NA L K
Sbjct: 1885 AEEAEEQSNANLSK 1898
Score = 68.6 bits (166), Expect = 2e-11
Identities = 122/613 (19%), Positives = 243/613 (39%), Gaps = 101/613 (16%)
Query: 155 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 214
K E+E + L+ +++EL A + EI R+ K +++R+ + + + ++
Sbjct: 1096 KIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1155
Query: 215 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS 274
G T + +++ FQK DLEE L+H DS
Sbjct: 1156 AG---GATSAQVELNKKREAEFQKLRRDLEEAT---------LQHEAMVAALRKKHADSM 1203
Query: 275 CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI 334
++ ID ++ K L + S+ +
Sbjct: 1204 A----------------ELGEQIDNLQR-----------------VKQKLEKEKSELKME 1230
Query: 335 TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT 394
T + LSS + +K + E SL +++ +++ EE Q
Sbjct: 1231 TDD-----LSSNAEAISKAKGNL---------EKMCRSLEDQVSELKTKE----EEQQRL 1272
Query: 395 LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE 454
+ +L+ Q+ +Q E + +DEK L + + ++ + +Q+ E+L + L+E K +
Sbjct: 1273 INDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAS---TQQIEELKHQLEEETKAK 1329
Query: 455 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 514
+ C + EQ E+E +Q+ L+ + +V + R K
Sbjct: 1330 NALAHA--LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQW---------RTKY 1378
Query: 515 ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASA-VEQ 573
E + + ELE + A+ L+E +E + + SL+ Q + + + VE+
Sbjct: 1379 ETDAIQRTEELEEAKKKL-AQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER 1437
Query: 574 TAESCEVQEMLKVARAEKDLLELS--CNELRQELLKANGEIKHVSSLLAKVEKDYSYLKE 631
+ +C + K +K L E E + EL + E + +S+ L KV+ Y +E
Sbjct: 1438 SNAACAALDK-KQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVY---EE 1493
Query: 632 ICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELES 691
D Q E L R + LQ++ S+ +I + + I ELE +Q K + E E+
Sbjct: 1494 SLD-QLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEA 1552
Query: 692 SV-----------IKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKC 740
S+ ++L + KS+++R++ + EE ++ +R + + D +
Sbjct: 1553 SLEHEEGKILRIQLELNQVKSEVDRKI----AEKDEEIDQLKRNHTRVVETMQSTLDAEI 1608
Query: 741 EAQQELRTVKRKL 753
++ + VK+K+
Sbjct: 1609 RSRNDALRVKKKM 1621
Score = 51.6 bits (122), Expect = 3e-06
Identities = 115/599 (19%), Positives = 223/599 (37%), Gaps = 68/599 (11%)
Query: 124 GPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEA-KAKDS 182
G + ++++S S TK+ + ++ E +K A Q E EA AK +
Sbjct: 1356 GKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCA 1415
Query: 183 EINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSD 242
+ + + L+ E L+ E ++A AL++K +NF K LS+
Sbjct: 1416 SLEKTKQRLQNEVEDLMLDVERSNAA-----------------CAALDKKQRNFDKVLSE 1458
Query: 243 LEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGN--QMSSDIDEY 300
+++ + +L + S + S+ Q + N Q SD+ E
Sbjct: 1459 WKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQ 1518
Query: 301 KKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS 360
+ G ++ K + E I A S K + +
Sbjct: 1519 --------IAEGGKQIHELEKIKKQVEQEKCE-IQAALEEAEASLEHEEGKILRIQLELN 1569
Query: 361 SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQE--------LSDQQQMVQELTAEN 412
S + +A E+I +++ NH E +Q+TL L +++M +L
Sbjct: 1570 QVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEME 1629
Query: 413 EKLVDEKTILETSFHQHRERAEQLSQENEKLMNLL--QERVKNEEPTTQE-GKIIELE-Q 468
+L + S +R L + L + L QE +K + + +++ E +
Sbjct: 1630 IQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIE 1689
Query: 469 KCTGILEQGRFEREKLLNIQQQLTCSLRK--VEEENQGALEMIKRLKEENEKLN----EF 522
+ LEQ ER + + Q+ L S R + +N + K+L+ + +L E
Sbjct: 1690 ELWATLEQT--ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEV 1747
Query: 523 LELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQE 582
++ R+ K + + + E LK E + +HL E+ K V+ + E
Sbjct: 1748 IQESRNAEEKAKKAITDAAMMAEELKKEQDT-SAHL--ERMKKNLEQTVKDLQHRLDEAE 1804
Query: 583 MLKVARAEKDLLELSC----------NELRQELLKANGEIKH---VSSLLAKVEKDYSY- 628
L + +K + +L NE ++ G KH V L + E+D
Sbjct: 1805 QLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNV 1864
Query: 629 --LKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQL 685
L+++ D ++ + +E +S+A + ++ ELE+ E+ + N+L
Sbjct: 1865 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKL 1923
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 95.9 bits (237), Expect = 1e-19
Identities = 142/598 (23%), Positives = 246/598 (41%), Gaps = 65/598 (10%)
Query: 221 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN-------SEGAASHTGDS 273
+TE + ++E+ + ++EL+ E + + L+EK++ L N +E A +
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEE 907
Query: 274 SC----PTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 329
C T I E+ T + + D +E NA T+ + + L D
Sbjct: 908 RCDQLIKTKIQLEAKIKEVT--ERAEDEEEI------NAELTAKKRKLEDECSELKKDID 959
Query: 330 DFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAE 389
D E A+ + K +T N E +A L E I K+ + + E
Sbjct: 960 DLELTLAKV------------EKEKHATENKVKNLTEE--MAGLDETIAKLTKEKKALQE 1005
Query: 390 ELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL---MNL 446
Q TL +L ++ V LT KL + LE S Q ++ L + KL + L
Sbjct: 1006 AHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKL 1065
Query: 447 LQERVKNEEPTTQE--GKIIELEQKCTGILEQGRFEREKLLNIQ-----QQLTCSLRKVE 499
QE + E Q+ K+ + E + + + QG+ E E+ L IQ ++L + ++E
Sbjct: 1066 AQESTMDTENDKQQLNEKLKKKEFEMSNL--QGKIEDEQALAIQLQKKIKELQARIEELE 1123
Query: 500 EENQGALEMIKRLKEENEKLNEFLELERHNNNM-------MAKTLEECRVTLEGLKMENG 552
EE + E R K E ++ + ELE + + A+ + E KM
Sbjct: 1124 EEIEA--ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRD 1181
Query: 553 SLKSHLQGEKQKATEASAVEQTAES-CEVQEMLKVARAEKDLLELSCNELRQELLKANGE 611
+S LQ E AT A+ ++ A+S E+ E + + K LE +EL+ E+
Sbjct: 1182 LEESTLQHE---ATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASN 1238
Query: 612 IKHVSSLLAKVEKDYSYLKEICDH---QAEQLSRTSLKLQEKASESDAEIKDMKETIFEL 668
++ VS A EK L++ + E+ R +L + + E + + E
Sbjct: 1239 METVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEK 1298
Query: 669 EDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ---MKEETEEWRRFQ 725
+ V Q K Q I EL+ + + + KS L L++ ++E+ EE + +
Sbjct: 1299 DAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAK 1358
Query: 726 ADLQTAVVVANDIKCEAQQELRTVKRKLLEE-EEKNARLQKELGDVQGHGRVVTSRAA 782
A+LQ + AN + + + T + EE EE +L + L D + H V S+ A
Sbjct: 1359 AELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCA 1416
Score = 78.2 bits (191), Expect = 3e-14
Identities = 95/405 (23%), Positives = 177/405 (43%), Gaps = 58/405 (14%)
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 435
K + E+ + EE + T +EL+ + +EL + L+ EK L+ Q + A+
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL---QVQAEADA 901
Query: 436 LSQENEKLMNLLQERVKNE----EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQL 491
L+ E+ L++ +++ E E T + E+ + T + E +L L
Sbjct: 902 LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 961
Query: 492 TCSLRKVEEENQGALEMIKRLKEENEKLNEFL-ELERHNNNMMAKTLEEC-RVTLEGLKM 549
+L KVE+E +K L EE L+E + +L + K L+E + TL+ L+M
Sbjct: 962 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK-----KALQEAHQQTLDDLQM 1016
Query: 550 ENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKAN 609
E + + + + + + +E + E EK L C +L + K
Sbjct: 1017 EEDKVNTLTKAKTKLEQQVDDLEGSLEQ------------EKKL----CMDLERAKRKLE 1060
Query: 610 GEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEK---ASESDAEIKDMKETIF 666
G++K E D L E + ++S K++++ A + +IK+++ I
Sbjct: 1061 GDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIE 1120
Query: 667 ELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQA 726
ELE+++E RA S K E+Q+SDL R+L+ ++++++E A
Sbjct: 1121 ELEEEIEAERA--------------SRAKAEKQRSDLSRELEEISERLEE---------A 1157
Query: 727 DLQTAVVVANDIKCEA--QQELRTVKRKLLEEEEKNARLQKELGD 769
T+ + + K EA Q+ R ++ L+ E A L+K+ D
Sbjct: 1158 GGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHAD 1202
Score = 71.2 bits (173), Expect = 3e-12
Identities = 128/661 (19%), Positives = 252/661 (38%), Gaps = 74/661 (11%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 221
EK A E++V+ L E D I +L E K +E + V+ + +
Sbjct: 971 EKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTK 1030
Query: 222 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKL-IYLEHSPNSEGAASHTGDSSCPTSIT 280
E + LE + +K DLE R L+ L + E + ++E +
Sbjct: 1031 LEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFE 1090
Query: 281 QESSFGSPTGNQ-MSSDIDEYKKNIHGNALRTSGSSSSD-VTKASLSPDASDFEHITAET 338
+ G Q ++ + + K + ++ ++A SD
Sbjct: 1091 MSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDL------- 1143
Query: 339 PSRPLSSTSNPFKSSKCSTAGS-SPNSVSELSLASLTEKIQKMEENHHSTAEELQAT-LQ 396
SR L S + + +T+ N E + +++ H +TA L+
Sbjct: 1144 -SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHAD 1202
Query: 397 ELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQEN---EKLMNLLQERVKN 453
+++ + + L +KL EK+ L+ + E +S+ EK+ L++++
Sbjct: 1203 SVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSE 1262
Query: 454 EEPTTQEGK--IIELE-QKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIK 510
+ +E + I EL QK E G F R+ L+ + + L + ++ +E +K
Sbjct: 1263 IKTKEEEQQRLINELSAQKARLHTESGEFSRQ--LDEKDAMVSQLSRGKQAFTQQIEELK 1320
Query: 511 RLKEENEK----LNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKAT 566
R EE K L L+ RH+ +++ + EE + L+ S + + K
Sbjct: 1321 RQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKY- 1379
Query: 567 EASAVEQTAESCEVQ----EMLKVARAEKDLLELSCNELRQELLKANGEI---------- 612
E A+++T E E + + L+ A + + C L + + E+
Sbjct: 1380 ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERS 1439
Query: 613 -----------KHVSSLLAKVEKDYSYLK---EICDHQAEQLSRTSLKLQEKASESDAEI 658
++ +LA+ ++ Y + E ++ LS K++ ES +
Sbjct: 1440 NAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHL 1499
Query: 659 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 718
+ +K L+ ++ + I ELE +L+ +KS+L+ L+ ++ E
Sbjct: 1500 ETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEE 1559
Query: 719 EEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVT 778
+ R Q +L N +K E + RK+ E++E+ +L++ H RVV
Sbjct: 1560 GKILRIQLEL-------NQVKSE-------IDRKIAEKDEELDQLKR------NHLRVVE 1599
Query: 779 S 779
S
Sbjct: 1600 S 1600
Score = 68.6 bits (166), Expect = 2e-11
Identities = 128/666 (19%), Positives = 253/666 (37%), Gaps = 87/666 (13%)
Query: 139 NTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKR 198
N K + + K E+E L+ +++EL A + + EI R+ K +++R
Sbjct: 1081 NEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1140
Query: 199 TLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLE 258
+ + + + ++ G T I +++ FQK DLEE L+
Sbjct: 1141 SDLSRELEEISERLEEAG---GATSAQIEMNKKREAEFQKMRRDLEEST---------LQ 1188
Query: 259 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNA--LRTSGSSS 316
H + DS + ++ ++ + E K I+ A + T +
Sbjct: 1189 HEATAAALRKKHADS--VAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAK 1246
Query: 317 SDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEK 376
++ K + + E T E + L + + K+ + +G + E ++ +
Sbjct: 1247 ANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKD--AMVSQ 1304
Query: 377 IQKMEENHHSTAEELQATLQE---------------------LSDQQQMVQELTAE---- 411
+ + ++ EEL+ L+E L +Q + QE AE
Sbjct: 1305 LSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRG 1364
Query: 412 ----NEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELE 467
N ++ +T ET Q R E+L + +KL LQ+ ++ E + +E
Sbjct: 1365 MSKANSEVAQWRTKYETDAIQ---RTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKT 1421
Query: 468 QKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELER 527
+ ++ + E E L+ ++ + ++++ + +++ K++ E+ LE +
Sbjct: 1422 K------QRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQ 1475
Query: 528 HNNNMMAKTL-------EECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEV 580
+ ++ L EE LE LK EN +LQ E TE A E E+
Sbjct: 1476 KESRSLSTELFKVKNAYEESLDHLETLKREN----KNLQQEISDLTEQIA-EGGKHIHEL 1530
Query: 581 QEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQL 640
+++ K EK L+ S E L G+I + L +V+ + D + +QL
Sbjct: 1531 EKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQL 1590
Query: 641 SRTSLKLQEK-ASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQ 699
R L++ E S DAEI+ + + ++ ++E + ++E Q
Sbjct: 1591 KRNHLRVVESMQSTLDAEIRSRNDAL------------------RIKKKMEGDLNEMEIQ 1632
Query: 700 KSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEK 759
+ RQ + ++ + Q L A+ +D+K + R E EE
Sbjct: 1633 LNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEEL 1692
Query: 760 NARLQK 765
A L++
Sbjct: 1693 RASLER 1698
Score = 64.3 bits (155), Expect = 4e-10
Identities = 141/702 (20%), Positives = 265/702 (37%), Gaps = 115/702 (16%)
Query: 163 KAALESQVREL---LAEAKAKDSEINRLRSELKKYKEKRTLNA-------EGTDALGPNV 212
KA E R L L+E K K+ E RL +EL K + + + DA+ +
Sbjct: 1246 KANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQL 1305
Query: 213 D-GTSVSPGDTEPMIRALEEKNKN-------FQKELSDLE------EENRVLKEKLIYLE 258
G E + R LEE+ K Q D + EE + K +L
Sbjct: 1306 SRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGM 1365
Query: 259 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNAL---RTSGSS 315
NSE A T + T+E Q D +E+ + ++ +T
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRL 1425
Query: 316 SSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTE 375
++V + + S+ I + R +K T S E SL+
Sbjct: 1426 QNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESR--SLST 1483
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAE--------------NEKLVDEKTI 421
++ K++ + + + L+ +E + QQ + +LT + ++L EK+
Sbjct: 1484 ELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSE 1543
Query: 422 LETSFHQHRERAEQLSQENEKLMNLLQE--RVKNEEPTTQEGKIIELEQ----------K 469
L+TS E L E K++ + E +VK+E K EL+Q
Sbjct: 1544 LQTSLE---EAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVES 1600
Query: 470 CTGILEQGRFEREKLLNIQQQLTCSLRKVEEE----NQGALEMIKRLKEEN--------- 516
L+ R L I++++ L ++E + N+ A E ++ L+
Sbjct: 1601 MQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLH 1660
Query: 517 --------EKLNEFLELERHNNNMMAKTLEECRVTLE----GLKMENGSL---------- 554
+ L E L + N+M +EE R +LE G KM L
Sbjct: 1661 LDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLL 1720
Query: 555 ----KSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANG 610
S + +K+ T+ S ++ E + +A+K + + + + +EL K
Sbjct: 1721 HTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAM--MAEELKKEQD 1778
Query: 611 EIKHVSSLLAKVEKDYSYLKEICDHQAEQLS-----RTSLKLQEKASESDAEIKDMKETI 665
H+ + +E+ L+ D +AEQL+ + KL+ + E ++E++ ++
Sbjct: 1779 TSAHLERMKKNMEQTVKDLQLRLD-EAEQLALKGGKKQIQKLEARVRELESEVESEQKHN 1837
Query: 666 FELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEE----- 720
E + +H E ++++L++ L+ ++K +Q +E E+
Sbjct: 1838 VEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNL 1897
Query: 721 --WRRFQADLQTAVVVANDIKCEAQQ---ELRTVKRKLLEEE 757
+R+ Q +L+ A A+ + + + + R V K++ EE
Sbjct: 1898 AKFRKLQHELEEAKERADIAESQVNKLRVKSREVHTKVISEE 1939
Score = 50.8 bits (120), Expect = 5e-06
Identities = 114/615 (18%), Positives = 243/615 (39%), Gaps = 73/615 (11%)
Query: 129 RKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEA-KAKDSEINRL 187
++ +S S TK+ + ++ E +K A Q E EA +K + + +
Sbjct: 1362 QRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKT 1421
Query: 188 RSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEEN 247
+ L+ E ++ E ++A +D + + ++ ++K + Q EL ++E+
Sbjct: 1422 KQRLQNEVEDLMIDVERSNAACIALDKKQ---RNFDKVLAEWKQKYEETQAELEASQKES 1478
Query: 248 RVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGN 307
R L +L ++++ E + H ++ +E+ + ++ I E K+IH
Sbjct: 1479 RSLSTELFKVKNA--YEESLDHL------ETLKRENKNLQQEISDLTEQIAEGGKHIH-- 1528
Query: 308 ALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSE 367
+ K L + S+ + E + S K + + S +
Sbjct: 1529 --------ELEKVKKQLDHEKSELQTSLEEAEA---SLEHEEGKILRIQLELNQVKSEID 1577
Query: 368 LSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFH 427
+A E++ +++ NH E +Q+TL + + + E ++E I H
Sbjct: 1578 RKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLN--H 1635
Query: 428 QHRERAEQLSQENEKLMNL------LQERVKNEEPTTQEGKIIELE--------QKCTGI 473
+R+ AE L L L + ++ ++ ++ ++E ++
Sbjct: 1636 ANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRAS 1695
Query: 474 LEQGRFEREKLLNIQQQLTCSLRK--VEEENQGALEMIKRLKEE----NEKLNEFLELER 527
LE R ER + + Q+ L S R + +N + K+L+ + ++ + ++ R
Sbjct: 1696 LE--RTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEAR 1753
Query: 528 HNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEV------Q 581
+ K + + + E LK E + +HL+ K+ +EQT + ++ Q
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDT-SAHLERMKKN------MEQTVKDLQLRLDEAEQ 1806
Query: 582 EMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLS 641
LK + + LE EL E+ E KH + + K +KE+ +Q E+
Sbjct: 1807 LALKGGKKQIQKLEARVRELESEV---ESEQKHNVEAVKGLRKHERRVKELT-YQTEEDR 1862
Query: 642 RTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKS 701
+ L+LQ+ + ++K K E E+Q + A +L+ + + +E+
Sbjct: 1863 KNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLA-------KFRKLQHELEEAKERAD 1915
Query: 702 DLERQLKTLTKQMKE 716
E Q+ L + +E
Sbjct: 1916 IAESQVNKLRVKSRE 1930
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 95.5 bits (236), Expect = 2e-19
Identities = 137/616 (22%), Positives = 249/616 (40%), Gaps = 101/616 (16%)
Query: 221 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN-----------SEGAASH 269
+TE + ++E+ + ++EL+ E + + L+EK++ L N S A
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEE 907
Query: 270 TGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 329
D T I E+ T + + D +E NA T+ + + L D
Sbjct: 908 RCDQLIKTKIQLEAKIKEVT--ERAEDEEEI------NAELTAKKRKLEDECSELKKDID 959
Query: 330 DFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAE 389
D E +T + +T N K+ AG + ++A LT++ + ++E H T +
Sbjct: 960 DLE-LTLAKVEKEKHATENKVKNLTEEMAG------LDETIAKLTKEKKALQEAHQQTLD 1012
Query: 390 ELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL---MNL 446
+LQA ++ V LT KL + LE S Q ++ L + KL + L
Sbjct: 1013 DLQA-------EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKL 1065
Query: 447 LQERVKNEEPTTQ--EGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQG 504
QE + E Q + K+ + E + +G+ Q + E E+ L +Q Q
Sbjct: 1066 AQESTMDIENDKQQLDEKLKKKEFEMSGL--QSKIEDEQALGMQLQ-------------- 1109
Query: 505 ALEMIKRLKEENEKLNEFLELER-------HNNNMMAKTLEECRVTLEGLKMENGSLKSH 557
+ IK L+ E+L E +E ER + +++ LEE E L+ G+ +
Sbjct: 1110 --KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS---ERLEEAGGATSAQ 1164
Query: 558 LQGEKQKATEASAVEQTAESCEVQEMLKVARAEK-------------DLLELSCNELRQE 604
++ K++ E + + E +Q A K D L+ +L +E
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKE 1224
Query: 605 LLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKET 664
+ EI ++S + V K L+++C +QLS +++ K E I D+
Sbjct: 1225 KSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLS----EIKTKEEEQQRLINDLTAQ 1280
Query: 665 IFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ----------- 713
L+ + ++ + L+S+L +Q +L+RQL+ K
Sbjct: 1281 RARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSS 1340
Query: 714 ------MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEE-EEKNARLQKE 766
++E+ EE + +A+LQ A+ AN + + + T + EE EE +L +
Sbjct: 1341 RHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1400
Query: 767 LGDVQGHGRVVTSRAA 782
L D + H V ++ A
Sbjct: 1401 LQDAEEHVEAVNAKCA 1416
Score = 78.6 bits (192), Expect = 2e-14
Identities = 153/704 (21%), Positives = 288/704 (40%), Gaps = 115/704 (16%)
Query: 163 KAALESQVREL---LAEAKAKDSEINRLRSELKKYKEK-RTLNAEGTDALGPNVDGTSVS 218
K LE R L L+E K K+ E RL ++L + + +T + E + L S
Sbjct: 1246 KGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQL 1305
Query: 219 PGDTEPMIRALEEKNKNFQKE--------------------LSDLEEENRVLKEKLIYLE 258
+ + +EE + ++E L + EE + K +L
Sbjct: 1306 SRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAM 1365
Query: 259 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNAL---RTSGSS 315
NSE A T + T+E Q D +E+ + ++ +T
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRL 1425
Query: 316 SSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTE 375
++V + + ++ + R +K KC + + S+ SL+
Sbjct: 1426 QNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQ-KCEETHAELEA-SQKESRSLST 1483
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELT---AENEKLVDEKTILETSFHQHRER 432
++ K++ + + ++L+ +E + QQ + +LT AE K + H+ +
Sbjct: 1484 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRI----------HELEKI 1533
Query: 433 AEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGIL-EQGRFEREKLLNIQQQL 491
+Q+ QE +L L+E + E +EGKI+ ++ + + E R EK I Q
Sbjct: 1534 KKQVEQEKSELQAALEEAEASLEH--EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMK 1591
Query: 492 TCSLRKVEE-------ENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTL 544
+R VE E + + I+ K+ LNE H N M A+ L R T
Sbjct: 1592 RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQ 1651
Query: 545 EGLKMENGSLKSHLQGEKQKATEASAVEQTAE--SCEVQEMLKVARAEKDLLELSCNELR 602
LK L L+ ++ + + VE+ A E++E+ RA + E S
Sbjct: 1652 AILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEEL----RATLEQTERSRKIAE 1707
Query: 603 QELLKANGEIKHV----SSLL---AKVEKDYSYLK-EICD-----HQAEQLSRTSL---- 645
QELL A+ ++ + +SL+ K+E D S ++ E+ D AE+ ++ ++
Sbjct: 1708 QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAA 1767
Query: 646 -------KLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLH-NNQLISELESSVIKLE 697
K Q+ ++ + K++++T+ +L+ ++++ + L + I +LE+ V +LE
Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELE 1827
Query: 698 -----EQKSDL---------ERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQ 743
EQK ++ ER++K LT Q +E+ + R Q D+ + Q
Sbjct: 1828 GEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQ-----------DLVDKLQ 1876
Query: 744 QELRTVKRKLLEEEE-------KNARLQKELGDVQGHGRVVTSR 780
++++ KR+ E EE K R+Q EL + + + S+
Sbjct: 1877 AKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQ 1920
Score = 74.3 bits (181), Expect = 4e-13
Identities = 94/406 (23%), Positives = 176/406 (43%), Gaps = 60/406 (14%)
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 435
K + E+ + EE + T +EL+ + +EL + L+ EK L+ Q + A+
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL---QVQAEADS 901
Query: 436 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 495
L+ E+ L++ + I+LE K + E+ E E I +LT
Sbjct: 902 LADAEERCDQLIKTK-------------IQLEAKIKEVTERAEDEEE----INAELTAKK 944
Query: 496 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 555
RK+E+E +K+ ++ E +E E+H K L E L+ + K
Sbjct: 945 RKLEDE----CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK 1000
Query: 556 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDL---LELSCNELRQELLKAN--- 609
LQ Q+ + E+ + + +K+ + DL LE ++R +L +A
Sbjct: 1001 KALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE-KKIRMDLERAKRKL 1059
Query: 610 -GEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKAS---ESDAEIKDMKETI 665
G++K +E D L E + ++S K++++ + + +IK+++ I
Sbjct: 1060 EGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARI 1119
Query: 666 FELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQ 725
ELE+++E RA S K E+Q+SDL R+L+ ++++++E
Sbjct: 1120 EELEEEIEAERA--------------SRAKAEKQRSDLSRELEEISERLEE--------- 1156
Query: 726 ADLQTAVVVANDIKCEA--QQELRTVKRKLLEEEEKNARLQKELGD 769
A T+ + + K EA Q+ R ++ L+ E A L+K+ D
Sbjct: 1157 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1202
Score = 74.3 bits (181), Expect = 4e-13
Identities = 138/646 (21%), Positives = 261/646 (40%), Gaps = 102/646 (15%)
Query: 145 KHLRTPSTKPKQENEGGEKAALESQV------RELLAEAKAKDSEINRLRSELKKYKEKR 198
K +R + K++ EG K A ES + ++L + K K+ E++ L+S K ++++
Sbjct: 1046 KKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQS---KIEDEQ 1102
Query: 199 TLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLE 258
L + L + + E I A +K+ SDL E + E+L
Sbjct: 1103 ALGMQ----LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL---- 1154
Query: 259 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSD 318
+ GA S + + +E+ F +M D++E A +
Sbjct: 1155 --EEAGGATS----AQIEMNKKREAEF-----QKMRRDLEEATLQHEATAATLRKKHADS 1203
Query: 319 VTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSEL--SLASLTEK 376
V A L + + + + L + K + S+ +VS+ +L +
Sbjct: 1204 V--AELGEQIDNLQRV-----KQKLEKEKSEMKM-EIDDLASNMETVSKAKGNLEKMCRA 1255
Query: 377 IQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQL 436
++ + EE Q + +L+ Q+ +Q + E + +DEK L + + ++
Sbjct: 1256 LEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQA---F 1312
Query: 437 SQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLR 496
+Q+ E+L L+E +K + + C + EQ E+E +Q+ ++ +
Sbjct: 1313 TQQIEELKRQLEEEIKAKSALAHA--LQSSRHDCDLLREQYEEEQEAKAELQRAMSKANS 1370
Query: 497 KVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKS 556
+V + R K E + + ELE + A+ L++ +E + + SL+
Sbjct: 1371 EVAQW---------RTKYETDAIQRTEELEEAKKKL-AQRLQDAEEHVEAVNAKCASLEK 1420
Query: 557 HLQGEKQKATEASA-VEQTAESCEVQEMLKVARAEKDLLELS--CNELRQELLKANGEIK 613
Q + + + VE+T +C + K +K L E C E EL + E +
Sbjct: 1421 TKQRLQNEVEDLMIDVERTNAACAALDK-KQRNFDKILAEWKQKCEETHAELEASQKESR 1479
Query: 614 HVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVE 673
+S+ L K++ Y +E D Q E L R + LQ+ EI D+ E I E
Sbjct: 1480 SLSTELFKIKNAY---EESLD-QLETLKRENKNLQQ-------EISDLTEQIAE------ 1522
Query: 674 QHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVV 733
+ I ELE ++E++KS+L+ L+ ++ E + R Q +L
Sbjct: 1523 --------GGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLEL----- 1569
Query: 734 VANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTS 779
N +K E V RK+ E++E+ ++++ H R+V S
Sbjct: 1570 --NQVKSE-------VDRKIAEKDEEIDQMKR------NHIRIVES 1600
Score = 70.1 bits (170), Expect = 8e-12
Identities = 119/649 (18%), Positives = 259/649 (39%), Gaps = 64/649 (9%)
Query: 145 KHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEG 204
K + K E+E L+ +++EL A + + EI R+ K +++R+ +
Sbjct: 1087 KEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE 1146
Query: 205 TDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSE 264
+ + ++ G T I +++ FQK DLEE L+H +
Sbjct: 1147 LEEISERLEEAG---GATSAQIEMNKKREAEFQKMRRDLEEAT---------LQHEATAA 1194
Query: 265 GAASHTGDSSCP-----TSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDV 319
DS ++ + ++M +ID+ N + T + ++
Sbjct: 1195 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN-----METVSKAKGNL 1249
Query: 320 TKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQK 379
K + + E T E + L + ++ + +G + E +L ++ +
Sbjct: 1250 EKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKD--TLVSQLSR 1307
Query: 380 MEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQE 439
++ EEL+ L+E + + + D +L + + +E +L +
Sbjct: 1308 GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCD---LLREQYEEEQEAKAELQRA 1364
Query: 440 NEKL-MNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKV 498
K + Q R K E Q + +E +K Q E + +N + SL K
Sbjct: 1365 MSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAK---CASLEKT 1421
Query: 499 EEENQGALE-MIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSH 557
++ Q +E ++ ++ N + +R+ + ++A+ ++C T + L++
Sbjct: 1422 KQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEET-------HAELEAS 1474
Query: 558 LQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSS 617
+ + +TE ++ E E + L+ + E L+ ++L +++ + I +
Sbjct: 1475 QKESRSLSTELFKIKNAYE--ESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK 1532
Query: 618 LLAKVEKDYSYLKEI-------CDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELED 670
+ +VE++ S L+ +H+ ++ R L+L + SE D +I + E I D
Sbjct: 1533 IKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI----D 1588
Query: 671 QVEQH--RAVKLHNNQLISELESS------VIKLEEQKSDLERQLKTLTKQMKEETEEWR 722
Q++++ R V+ + L +E+ S K+E +++E QL + E +R
Sbjct: 1589 QMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYR 1648
Query: 723 RFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 771
QA L+ + +D A + +K +L E + LQ E+ +++
Sbjct: 1649 NTQAILKDTQLHLDD----ALRSQEDLKEQLAMVERRANLLQAEIEELR 1693
Score = 64.3 bits (155), Expect = 4e-10
Identities = 150/691 (21%), Positives = 271/691 (39%), Gaps = 115/691 (16%)
Query: 163 KAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDT 222
K LE++++E+ A+ ++ EIN +EL +KR L E ++ L ++D ++
Sbjct: 916 KIQLEAKIKEVTERAEDEE-EIN---AELTA--KKRKLEDECSE-LKKDIDDLELTLAKV 968
Query: 223 EPMIRALEEKNKNFQKELSDLEEE-NRVLKEKLIYLE-HSPNSEG--AASHTGDSSCPTS 278
E A E K KN +E++ L+E ++ KEK E H + A ++
Sbjct: 969 EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK 1028
Query: 279 ITQESSFGSPTGN-----QMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPD----AS 329
I E G+ ++ D++ K+ + G+ L+ + S+ D+ D
Sbjct: 1029 IKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGD-LKLAQESTMDIENDKQQLDEKLKKK 1087
Query: 330 DF----------------------------------EHITAETPSR-----PLSSTSNPF 350
+F E I AE SR S S
Sbjct: 1088 EFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1147
Query: 351 K--SSKCSTAGSSPNSVSELSLASLTEKIQKMEEN-------HHSTAEELQA----TLQE 397
+ S + AG + ++ E++ E QKM + H +TA L+ ++ E
Sbjct: 1148 EEISERLEEAGGATSAQIEMNKKREAE-FQKMRRDLEEATLQHEATAATLRKKHADSVAE 1206
Query: 398 LSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQER---VKNE 454
L +Q +Q + + EK E + + E + EK+ L+++ +K +
Sbjct: 1207 LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTK 1266
Query: 455 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 514
E Q Q+ E G + R+ L+ + L L + ++ +E +KR E
Sbjct: 1267 EEEQQRLINDLTAQRARLQTESGEYSRQ--LDEKDTLVSQLSRGKQAFTQQIEELKRQLE 1324
Query: 515 ENEK----LNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASA 570
E K L L+ RH+ +++ + E E K+ LQ KA A
Sbjct: 1325 EEIKAKSALAHALQSSRHDCDLLREQYE-----------EEQEAKAELQRAMSKANSEVA 1373
Query: 571 VEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLK 630
+T + + R E+ LE + +L Q L A ++ V++ A +EK L+
Sbjct: 1374 QWRTKYETDA-----IQRTEE--LEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQ 1426
Query: 631 EICDHQAEQLSRTS---LKLQEKASESDAEIKDMK----ETIFELEDQVEQHRAVKLHNN 683
+ + RT+ L +K D + + K ET ELE ++ R++
Sbjct: 1427 NEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELF 1486
Query: 684 QLISELESSVIKLE---EQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKC 740
++ + E S+ +LE + +L++++ LT+Q+ E + +L+ K
Sbjct: 1487 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH----ELEKIKKQVEQEKS 1542
Query: 741 EAQQELRTVKRKLLEEEEKNARLQKELGDVQ 771
E Q L + L EE K R+Q EL V+
Sbjct: 1543 ELQAALEEAEASLEHEEGKILRIQLELNQVK 1573
Score = 62.4 bits (150), Expect = 2e-09
Identities = 74/303 (24%), Positives = 127/303 (41%), Gaps = 56/303 (18%)
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 554
L+ E E + A +KEE EK E E K LEE VTL E L
Sbjct: 844 LKSAETEKEMA-----NMKEEFEKTKE----ELAKTEAKRKELEEKMVTL---MQEKNDL 891
Query: 555 KSHLQGEKQKATEA---------------SAVEQTAESCEVQEMLKVA-RAEKDLLELSC 598
+ +Q E +A + +++ E E +E + A+K LE C
Sbjct: 892 QLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 951
Query: 599 NELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEI 658
+EL+++ I + LAKVEK+ K +++ + L+ L E ++ E
Sbjct: 952 SELKKD-------IDDLELTLAKVEKE----KHATENKVKNLTEEMAGLDETIAKLTKEK 1000
Query: 659 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 718
K ++E + D ++ ++ L + IKLE+Q DLE L+ K +
Sbjct: 1001 KALQEAHQQTLDDLQAEE-------DKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLE 1053
Query: 719 EEWRRFQADLQTAVVVANDIKCEAQQ----------ELRTVKRKLLEEEEKNARLQKELG 768
R+ + DL+ A DI+ + QQ E+ ++ K+ +E+ +LQK++
Sbjct: 1054 RAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIK 1113
Query: 769 DVQ 771
++Q
Sbjct: 1114 ELQ 1116
Score = 54.7 bits (130), Expect = 3e-07
Identities = 112/511 (21%), Positives = 198/511 (38%), Gaps = 97/511 (18%)
Query: 155 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 214
KQ N A + + E AE +A E L +EL K K +A ++D
Sbjct: 1449 KQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIK----------NAYEESLD- 1497
Query: 215 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEE---------------NRVLKEKLIYLEH 259
+ L+ +NKN Q+E+SDL E+ +V +EK
Sbjct: 1498 ----------QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAA 1547
Query: 260 SPNSEGAASHTGDS--SCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGS--- 314
+E + H + Q S + +ID+ K+N H + + S
Sbjct: 1548 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRN-HIRIVESMQSTLD 1606
Query: 315 ----SSSDVT--KASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSEL 368
S +D K + D ++ E I +R + +++++ + + L
Sbjct: 1607 AEIRSRNDAIRLKKKMEGDLNEME-IQLNHANRMAAEALRNYRNTQAILKDTQLHLDDAL 1665
Query: 369 -SLASLTEKIQKMEENHH---STAEELQATL-----------QELSDQQQMVQELTAENE 413
S L E++ +E + + EEL+ATL QEL D + VQ L +N
Sbjct: 1666 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1725
Query: 414 KLVDEKTILETSFHQHRERAEQLSQE----NEKLMN------LLQERVKNEEPTTQEGKI 463
L++ K LET Q + E + QE EK ++ E +K E+ T+ +
Sbjct: 1726 SLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785
Query: 464 IELEQKCTGILEQGRFEREKLLNIQ------QQLTCSLR----KVEEENQGALEMIKRLK 513
++ + T Q R + + L ++ Q+L +R +VE E + +E +K L+
Sbjct: 1786 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLR 1845
Query: 514 EENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQ 573
+ K+ E + EE R + L+ L++ ++ K++A EA
Sbjct: 1846 KHERKVKE-----------LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSN 1894
Query: 574 T--AESCEVQEMLKVARAEKDLLELSCNELR 602
++ +Q L+ A D+ E N+LR
Sbjct: 1895 VNLSKFRRIQHELEEAEERADIAESQVNKLR 1925
Score = 47.8 bits (112), Expect = 4e-05
Identities = 114/607 (18%), Positives = 224/607 (36%), Gaps = 94/607 (15%)
Query: 129 RKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEA-KAKDSEINRL 187
++++S S TK+ + ++ E +K A Q E EA AK + + +
Sbjct: 1362 QRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKT 1421
Query: 188 RSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEEN 247
+ L+ E ++ E T+A +D + + ++ ++K + EL ++E+
Sbjct: 1422 KQRLQNEVEDLMIDVERTNAACAALDKKQ---RNFDKILAEWKQKCEETHAELEASQKES 1478
Query: 248 RVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHG- 306
R L +L ++++ T + +E+ + ++ I E K IH
Sbjct: 1479 RSLSTELFKIKNAYEESLDQLET--------LKRENKNLQQEISDLTEQIAEGGKRIHEL 1530
Query: 307 NALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVS 366
++ +A+L + EH E + N KS
Sbjct: 1531 EKIKKQVEQEKSELQAALEEAEASLEH--EEGKILRIQLELNQVKSEV------------ 1576
Query: 367 ELSLASLTEKIQKMEENHHSTAEELQATLQ---------------------ELSDQQQMV 405
+ +A E+I +M+ NH E +Q+TL E+ Q
Sbjct: 1577 DRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHA 1636
Query: 406 QELTAENEK--------LVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPT 457
+ AE + L D + L+ + + EQL+ E+ NLLQ ++ T
Sbjct: 1637 NRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMV-ERRANLLQAEIEELRAT 1695
Query: 458 TQEGKIIELEQKCTGILEQGRF---EREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 514
+E ++ I EQ ER +LL+ Q + +K E + I +++
Sbjct: 1696 ------LEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD------ISQIQG 1743
Query: 515 ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT 574
E E + ++ R+ K + + + E LK E + +HL E+ K V+
Sbjct: 1744 EME---DIIQEARNAEEKAKKAITDAAMMAEELKKEQDT-SAHL--ERMKKNLEQTVKDL 1797
Query: 575 AESCEVQEMLKVARAEKDL--LELSCNELRQE--------------LLKANGEIKHVSSL 618
+ E L + +K + LE EL E L K ++K ++
Sbjct: 1798 QHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQ 1857
Query: 619 LAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAV 678
+ K+ L+++ D ++ + +E +S+ + + ELE+ E+
Sbjct: 1858 TEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIA 1917
Query: 679 KLHNNQL 685
+ N+L
Sbjct: 1918 ESQVNKL 1924
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 94.0 bits (232), Expect = 5e-19
Identities = 125/575 (21%), Positives = 244/575 (42%), Gaps = 93/575 (16%)
Query: 232 KNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGN 291
K+ +KE++ ++E+ KE+L SE + S+ QE N
Sbjct: 845 KSAEAEKEMATMKEDFERTKEELA------RSEARRKELEEKM--VSLLQEK-------N 889
Query: 292 QMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFK 351
+ + +N+ R G S + + + ++ E S ++ N
Sbjct: 890 DLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRN--L 947
Query: 352 SSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAE 411
KCS S + +L L + K+E+ H+T +++ +E++ ++ + +LT E
Sbjct: 948 EDKCS---SLKRDIDDLELT-----LTKVEKEKHATENKVKNLSEEMTALEENISKLTKE 999
Query: 412 NEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCT 471
+ L + H++ + L E +K+ L++ K E+ T +E E+K
Sbjct: 1000 KKSLQEA----------HQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLR 1049
Query: 472 GILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNN 531
LE+ + + E L + Q+ S+ +E + Q E +K+ + E +L ++ E+ ++
Sbjct: 1050 ADLERAKRKLEGDLKMSQE---SIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSL 1106
Query: 532 MMAKTLEECRVTLEGLKME---NGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVAR 588
K ++E + +E L+ E +L++ + EKQ++ A +E+ +E E A+
Sbjct: 1107 QFQKKIKELQARIEELEEEIEAEHTLRAKI--EKQRSDLARELEEISERLEEASGATSAQ 1164
Query: 589 AEKDLL-ELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKL 647
E + E ++R++L +A + + ++ L K + D + E+ + Q + L R KL
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADS--VAELGE-QIDNLQRVKQKL 1221
Query: 648 QEKASESDAEIKDMKETIFEL--------------EDQVEQHRAVKLHNNQLISEL---- 689
+++ SE EI DM I L EDQ + +A QLI +L
Sbjct: 1222 EKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQK 1281
Query: 690 -----------------ESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAV 732
ES + +L + K L +QL+ L +QM+EET+ LQ+
Sbjct: 1282 ARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQS-- 1339
Query: 733 VVANDIKCEAQQELRTVKRKLLEEEEKNARLQKEL 767
++ + ++ + EE+E A LQ+ L
Sbjct: 1340 ---------SRHDCDLLREQYEEEQEAKAELQRAL 1365
Score = 82.8 bits (203), Expect = 1e-15
Identities = 141/698 (20%), Positives = 274/698 (39%), Gaps = 103/698 (14%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKE--KRTLN------------------ 201
EK A E++V+ L E A + I++L E K +E ++TL+
Sbjct: 971 EKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAK 1030
Query: 202 -AEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEK------- 253
+ TD L +++ D E R LE K Q+ + DLE + + ++EK
Sbjct: 1031 LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFE 1090
Query: 254 LIYLEHSPNSEGAAS----------HTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKN 303
L L+ + E S I E + + Q SD+ +
Sbjct: 1091 LSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQ-RSDLARELEE 1149
Query: 304 IHGNALRTSGSSSSDV-----TKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTA 358
I SG++S+ + +A D E T + ++T ++ +
Sbjct: 1150 ISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQ--HEATAATLRKKQADSVAEL 1207
Query: 359 GSSPNSV-----------SEL-----SLASLTEKIQKMEENHHSTAEELQATLQEL---- 398
G +++ SEL +AS E + K + N T ++ E+
Sbjct: 1208 GEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKD 1267
Query: 399 SDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQE-RVKNEEPT 457
Q Q++ +L + +L + L + QL++ + L L+E + + EE T
Sbjct: 1268 EQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEET 1327
Query: 458 TQEGKIIELEQK----CTGILEQGRFEREKLLNIQQQLTCSLRKVEE----ENQGALEMI 509
+ + Q C + EQ E+E +Q+ L+ + +V + A++
Sbjct: 1328 KAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRT 1387
Query: 510 KRLKEENEKLNEFLELERHNN---NMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKAT 566
+ L+E +KL + L+ N N +LE+ + L+ G ++ ++ ++ T
Sbjct: 1388 EELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQ------GEVEDLMRDLERSHT 1441
Query: 567 EASAVEQTAES-----CEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAK 621
+ +++ + E ++ L ++AE + + L EL K + V L
Sbjct: 1442 ACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLET 1501
Query: 622 VEKDYSYLKEICDHQAEQLSRTSLKLQEKASES---DAEIKDMKETIFELEDQVEQHRA- 677
+ ++ L+E EQ++ T LQE + E D++ + E+E +E +
Sbjct: 1502 LRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESK 1561
Query: 678 ---VKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVV 734
V+L +Q+ SEL+ VI+ +E+ L+R + + ++ + R + D
Sbjct: 1562 ILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRND------- 1614
Query: 735 ANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQG 772
A +K + + +L ++ +L + A QK L VQG
Sbjct: 1615 ALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQG 1652
Score = 70.5 bits (171), Expect = 6e-12
Identities = 147/676 (21%), Positives = 274/676 (40%), Gaps = 85/676 (12%)
Query: 163 KAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDT 222
K LE++V+EL E ++ E+N SEL +KR L + +L ++D ++
Sbjct: 916 KILLEAKVKEL-TERLEEEEEMN---SEL--VAKKRNLE-DKCSSLKRDIDDLELTLTKV 968
Query: 223 EPMIRALEEKNKNFQKELSDLEEE-NRVLKEKLIYLE-HSPNSEGAASHTGDSSCPTSI- 279
E A E K KN +E++ LEE +++ KEK E H + + I
Sbjct: 969 EKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKIN 1028
Query: 280 ------TQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDV------TKASLSPD 327
T + ++ +D++ K+ + G+ L+ S S D+ + L
Sbjct: 1029 AKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGD-LKMSQESIMDLENDKQQIEEKLKKK 1087
Query: 328 ASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHST 387
+ + A+ + S K + E +L KI+K +
Sbjct: 1088 EFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAE-HTLRAKIEKQRSDLARE 1146
Query: 388 AEELQATLQELSD----QQQMVQELTAENEKL---VDEKTILE--TSFHQHRERAEQLSQ 438
EE+ L+E S Q +M ++ AE +K+ ++E T+ T+ +++A+ +++
Sbjct: 1147 LEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAE 1206
Query: 439 ENEKLMNLLQERVKNEEPTTQEGKIIE---------------LEQKCTGILEQGRFEREK 483
E++ NL + + K E+ ++ I+ +E+ C + +Q F K
Sbjct: 1207 LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQ--FSEIK 1264
Query: 484 LLNIQQ-QLTCSL---------------RKVEEENQGALEMIK---RLKEENEKLNEFLE 524
+ QQ QL L +VEE+ ++ K L ++ E+L +E
Sbjct: 1265 AKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQME 1324
Query: 525 LERHNNNMMAKTLEECRVTLEGLK---MENGSLKSHLQGEKQKATEASAVEQTAESCEVQ 581
E N MA L+ R + L+ E K+ LQ KA A +T +
Sbjct: 1325 EETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDA- 1383
Query: 582 EMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLS 641
+ R E+ LE + +L Q L +A + +S A +EK L+ + L
Sbjct: 1384 ----IQRTEE--LEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLE 1437
Query: 642 RT---SLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEE 698
R+ L +K D + + K+ + E + ++E + + + ++ ++ ++ +
Sbjct: 1438 RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVD 1497
Query: 699 QKSDLERQLKTLTKQMKEETEEWRRFQADLQTA---VVVANDIKCEAQQELRTVKRKLLE 755
Q L R+ K L +++ + TE+ +LQ A + K + Q L V+ L
Sbjct: 1498 QLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEH 1557
Query: 756 EEEKNARLQKELGDVQ 771
EE K R+Q EL V+
Sbjct: 1558 EESKILRVQLELSQVK 1573
Score = 68.9 bits (167), Expect = 2e-11
Identities = 93/408 (22%), Positives = 165/408 (40%), Gaps = 83/408 (20%)
Query: 375 EKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 434
E++ + E E++ + LQE +D Q VQ +E E L+D + ER E
Sbjct: 865 EELARSEARRKELEEKMVSLLQEKNDLQLQVQ---SETENLMDAE-----------ERCE 910
Query: 435 QLSQEN---EKLMNLLQERVKNEEPTTQE--GKIIELEQKCTGILEQGRFEREKLLNIQQ 489
L + E + L ER++ EE E K LE KC+ +
Sbjct: 911 GLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRD-----------ID 959
Query: 490 QLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEEC-RVTLEGLK 548
L +L KVE+E +K L EE L E + K+L+E + TL+ L+
Sbjct: 960 DLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEK----KSLQEAHQQTLDDLQ 1015
Query: 549 ME----NGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQE 604
+E NG +K + + E+Q ++EQ K RA+ L +
Sbjct: 1016 VEEDKVNGLIKINAKLEQQTDDLEGSLEQE----------KKLRAD----------LERA 1055
Query: 605 LLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASES---DAEIKDM 661
K G++K + +E D ++E + +LS+ K+ ++ S +IK++
Sbjct: 1056 KRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKEL 1115
Query: 662 KETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEW 721
+ I ELE+++E ++ K+E+Q+S L ++++E +E
Sbjct: 1116 QARIEELEEEIEAEHTLRA--------------KIEKQRS-------DLARELEEISERL 1154
Query: 722 RRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGD 769
+ + + E Q+ R ++ L+ E A L+K+ D
Sbjct: 1155 EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQAD 1202
Score = 66.2 bits (160), Expect = 1e-10
Identities = 145/717 (20%), Positives = 274/717 (38%), Gaps = 141/717 (19%)
Query: 145 KHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEG 204
K + K ++E + +++EL A + + EI + K +++R+ A
Sbjct: 1087 KEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARE 1146
Query: 205 TDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSE 264
+ + ++ S G T I +++ FQK DLEE L+H +
Sbjct: 1147 LEEISERLEEAS---GATSAQIEMNKKREAEFQKMRRDLEEAT---------LQHEATAA 1194
Query: 265 GAASHTGDSSCPTS------------ITQESSFGSPTGNQMSSDIDEYKKNIHGNALRT- 311
DS + +E S + M+S+I+ K+ N RT
Sbjct: 1195 TLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKS-KSNIERTC 1253
Query: 312 -------SGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNS 364
S + D + L D + + +T + LS K S S S +
Sbjct: 1254 RTVEDQFSEIKAKDEQQTQLIHDLN-MQKARLQTQNGELSHRVEE-KESLISQLTKSKQA 1311
Query: 365 VSELSLASLTEKIQKMEENHHSTAEELQATLQE---LSDQQQMVQELTAE--------NE 413
+++ L L ++++ + ++ A LQ++ + L +Q + QE AE N
Sbjct: 1312 LTQ-QLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANS 1370
Query: 414 KLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGI 473
++ +T ET Q R E+L + +KL LQE +N E T K LE+ +
Sbjct: 1371 EVAQWRTKYETDAIQ---RTEELEEAKKKLAQRLQEAEENTE--TANSKCASLEKTKQRL 1425
Query: 474 LEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMM 533
QG E E L+ ++ + ++++ + +++ K++ ++ LE + + +
Sbjct: 1426 --QG--EVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSL 1481
Query: 534 AKTL-------EECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKV 586
+ L EE LE L+ EN +L+ + + T + E + L+
Sbjct: 1482 STELFKMRNAYEEVVDQLETLRRENKNLQEEIS------------DLTEQIAETGKNLQE 1529
Query: 587 ARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQA-------EQ 639
A K L+E ++L+ L + G ++H S + +V+ + S +K D + EQ
Sbjct: 1530 AEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQ 1589
Query: 640 LSRTSLKLQEKA-SESDAEIK--------------DMKETIFEL---------------- 668
L R S + E S DAEI+ D+ E +L
Sbjct: 1590 LKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRT 1649
Query: 669 -------------------EDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKT 709
ED EQ V+ N L+ ELE + LE+ ER +
Sbjct: 1650 VQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQ----TERTRRL 1705
Query: 710 LTKQMKEETEEWRRFQADLQTAV-----VVANDIKCEAQQELRTVKRKLLEEEEKNA 761
+++ + ++ + + + + + A+ +C+A+ E + + EE+ K A
Sbjct: 1706 SEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKA 1762
Score = 64.3 bits (155), Expect = 4e-10
Identities = 129/638 (20%), Positives = 249/638 (39%), Gaps = 76/638 (11%)
Query: 166 LESQVRELLAEAKAKDSEINRLRSEL-------KKYKEKRTLNAEGTDALGPNVDGTSV- 217
LE R++ E KAK++ + L+S ++Y+E++ AE AL +
Sbjct: 1316 LEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQW 1375
Query: 218 -SPGDTEPMIRA--LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNS----------E 264
+ +T+ + R LEE K + L + EE K LE + +
Sbjct: 1376 RTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRD 1435
Query: 265 GAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASL 324
SHT +C T ++ +F + +DE + + A + S S S+++ K
Sbjct: 1436 LERSHT---ACATLDKKQRNFDKVLA-EWKQKLDESQAELEA-AQKESRSLSTELFKMRN 1490
Query: 325 SPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENH 384
+ + + T ++ L + T L A T+K+ + E++
Sbjct: 1491 AYEEVVDQLETLRRENKNLQEEISDLTEQIAETG-------KNLQEAEKTKKLVEQEKSD 1543
Query: 385 HSTA-EELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL 443
A EE++ +L+ + VQ ++ + +D K I + E EQL + +++
Sbjct: 1544 LQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVI------EKDEEIEQLKRNSQRA 1597
Query: 444 MNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQ 503
LQ + E + + + L++K G L + + + LR V+ + +
Sbjct: 1598 AEALQSVLDAEIRSRNDA--LRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLK 1655
Query: 504 GALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQ 563
+ + NE L E L + N ++ + LEE +V LE + + L
Sbjct: 1656 DSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASD 1715
Query: 564 KA-----------TEASAVEQTAESC--EVQEMLKVARAEKDLLELSCNE---LRQELLK 607
+ +E C EV+ ++ +R ++ + + + + +EL K
Sbjct: 1716 RVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKK 1775
Query: 608 ANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLS---------RTSLKLQEKASESDAEI 658
H+ + +E+ L+ D +AEQL+ + +++E +E D E
Sbjct: 1776 EQDTSAHLERMKKNLEQTVKDLQHRLD-EAEQLALKGGKKQIQKLENRVRELENELDVEQ 1834
Query: 659 KDMKETI-----FELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ 713
K E + +E + + ++A + H N I L+ V KL+ + +RQ + +Q
Sbjct: 1835 KRGAEALKGAHKYERKVKEMTYQAEEDHKN--ILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1892
Query: 714 MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKR 751
+ RR Q +L+ A A DI +LR R
Sbjct: 1893 ANTQLSRCRRVQHELEEAAERA-DIAESQVNKLRAKSR 1929
Score = 53.1 bits (126), Expect = 1e-06
Identities = 109/573 (19%), Positives = 221/573 (38%), Gaps = 47/573 (8%)
Query: 176 EAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVS-PGDTEPMIRALE---- 230
+A + E+ + +L + ++ N E ++ +++ T G+ E ++R LE
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHT 1441
Query: 231 ------EKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESS 284
+K +NF K L++ +++ + +L + S ++ + Q +
Sbjct: 1442 ACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLET 1501
Query: 285 FGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLS 344
N + +I + + I A ++ TK + + SD + E S
Sbjct: 1502 LRRENKN-LQEEISDLTEQI---AETGKNLQEAEKTKKLVEQEKSDLQVALEEVEG---S 1554
Query: 345 STSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQM 404
K + S S + + E+I++++ N AE LQ+ L +
Sbjct: 1555 LEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRND 1614
Query: 405 VQELTAENEKLVDEKTILETSFHQHRERAE----------QLSQENEKLMNLLQERVKNE 454
L + E ++E I H +R+ AE QL L + L+ +
Sbjct: 1615 ALRLKKKMEGDLNEMEI--QLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLK 1672
Query: 455 EPTT----QEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCS--LRKVEEENQGALEM 508
E + G ++E ++ LEQ ER + L+ Q+ L S ++ + +N +
Sbjct: 1673 EQLAIVERRNGLLLEELEEMKVALEQT--ERTRRLSEQELLDASDRVQLLHSQNTSLINT 1730
Query: 509 IKRLKEE----NEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQK 564
K+L+ + ++ ++ R+ K + + + E LK E + +HL E+ K
Sbjct: 1731 KKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDT-SAHL--ERMK 1787
Query: 565 ATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEK 624
V+ + E L + +K + +L N +R+ + + E K + L K
Sbjct: 1788 KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE-NRVRELENELDVEQKRGAEALKGAHK 1846
Query: 625 DYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQ 684
+KE+ +QAE+ + L+LQ+ + A++K K E E+Q +
Sbjct: 1847 YERKVKEMT-YQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQH 1905
Query: 685 LISELESSVIKLEEQKSDLERQLKTLTKQMKEE 717
+ E E Q + L + + + Q EE
Sbjct: 1906 ELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 94.0 bits (232), Expect = 5e-19
Identities = 139/645 (21%), Positives = 271/645 (42%), Gaps = 68/645 (10%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRT-LNAEGTDALGPNVDGTSVSPG 220
E L+ +++EL K +++I +S+L+ K+ + L E A TS+ G
Sbjct: 647 ENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDG 706
Query: 221 DTEPMIRA---LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPT 277
+ LE K + QKEL+ EEN L+E++I L +
Sbjct: 707 KVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDK 766
Query: 278 SITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAE 337
S +E + +++ S++ + + G L G + D+ + ++D E +
Sbjct: 767 S--EELHIITSEKDKLFSEVVHKESRVQG-LLEEIGKTKDDLATTQSNYKSTDQEFQNFK 823
Query: 338 TPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQE 397
T N + +L+++ QK + + + EL QE
Sbjct: 824 TLHMDFEQKYKMVLEE---------NERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQE 874
Query: 398 LSDQQQMVQELTAENEKLVDE----KTILETSFHQHRERAEQLSQENEKLMNLLQERVKN 453
L ++ + VQE E E+L ++ + L+T + E+L Q E++ L QE K+
Sbjct: 875 LQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQE--KD 932
Query: 454 EEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLK 513
+ QE IE +Q + I + ++ Q+QL +L +++ E I LK
Sbjct: 933 DLKQLQESLQIERDQLKSDIHDTVNMN----IDTQEQLRNALESLKQHQ----ETINTLK 984
Query: 514 EENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQ 573
K++E + H +T +E + + G+ + + Q + +EQ
Sbjct: 985 ---SKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQ 1041
Query: 574 -------TAESCEVQEMLKVARAEKDLLELSCN-------ELRQELLKANGEIKHVSSLL 619
E E+Q+ML+ AEK+ L+ E ++EL E+K ++
Sbjct: 1042 QRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIV 1101
Query: 620 AKVEKDYSYLKE-----ICDHQA---EQLSRTSLKLQEKASE---SDAEIKDMKETIFEL 668
A+ EK+++ KE CD A E+L S +LQEK + E+ +M++ I E+
Sbjct: 1102 AQ-EKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI 1160
Query: 669 EDQVEQHRAVKLHNNQL-ISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQAD 727
E+ + L N +L + +E+ ++L ++ ++ ++K++TK+ K E + F+ +
Sbjct: 1161 ENLKNE-----LKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETE 1215
Query: 728 LQTAVVVANDIKC---EAQQELRTVKRKLLEEEEKNARLQKELGD 769
+I+ + ++EL+ L E +E L++ + +
Sbjct: 1216 RDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE 1260
Score = 80.1 bits (196), Expect = 7e-15
Identities = 89/413 (21%), Positives = 184/413 (44%), Gaps = 40/413 (9%)
Query: 375 EKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENE--KLVDEKTILETSFHQHRER 432
E +Q + +E+ A ++E +++ ++TA NE + + E L+ F +
Sbjct: 1600 EALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLN 1659
Query: 433 AEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLL-NIQQQL 491
E + EN +L +L E ++ T+E + E + ER++L N+++ +
Sbjct: 1660 LENIETENIRLTQILHENLEEMRSVTKE------RDDLRSVEETLKVERDQLKENLRETI 1713
Query: 492 TCSLRKVEE---------ENQGALEMIKRLKEE--NEKLNEFLELERHNNNMMAKTL--- 537
T L K EE E+Q ++ ++ + E NE N +LE N+ + A+ L
Sbjct: 1714 TRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ 1773
Query: 538 EECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELS 597
EE R+ LK + ++ +K + S +++ E+ A+ ++ + EL
Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSN-------AKLQEKIQELK 1826
Query: 598 CNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAE 657
NE + LK K V+ KV + K+I D Q+ LS+ ++ A +
Sbjct: 1827 ANEHQLITLK-----KDVNETQKKVSEMEQLKKQIKD-QSLTLSKLEIENLNLAQKLHEN 1880
Query: 658 IKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEE 717
+++MK + E ++ +KL +QL L+ + + + +++++LKT KE
Sbjct: 1881 LEEMKSVMKERDNLRRVEETLKLERDQLKESLQET----KARDLEIQQELKTARMLSKEH 1936
Query: 718 TEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDV 770
E + + + + +DI+ + + +++K+ E ++K +L + DV
Sbjct: 1937 KETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDV 1989
Score = 78.6 bits (192), Expect = 2e-14
Identities = 118/647 (18%), Positives = 264/647 (40%), Gaps = 48/647 (7%)
Query: 147 LRTPSTKPKQENEG--------GEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKR 198
L+ K +ENE E +L S+V L E + K E++ + SE K +
Sbjct: 725 LQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEV 784
Query: 199 TLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLE 258
L + T T+ ++ +++ +NF+ D E++ +++ E+ +
Sbjct: 785 VHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMN 844
Query: 259 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSD 318
+ + DSS ++ E S+ + + + ++ E + +
Sbjct: 845 QEIVNLSKEAQKFDSSL-GALKTELSYKTQELQEKTREVQERLNEM-------------E 890
Query: 319 VTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQ 378
K L S + + E + L + + T + + +L + E+ Q
Sbjct: 891 QLKEQLENRDSTLQTVERE---KTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQ 947
Query: 379 KMEENHHS------TAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRER 432
+ H + T E+L+ L+ L Q+ + L ++ + V +E + + ++
Sbjct: 948 LKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDE 1007
Query: 433 AEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNI---QQ 489
+Q +K +L + + ++ +IIE ++K ++++ ++ L ++ ++
Sbjct: 1008 FQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKE 1067
Query: 490 QLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHN----NNMMAKTLEECRVTLE 545
QL L++ E E ++ L +E +K E + E+++ +++T + E
Sbjct: 1068 QLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE 1127
Query: 546 GLKMENGSLKSHLQGEKQKATEASAVEQTAESCE-VQEMLKVARAEKDLLELSCNELRQE 604
LK ++ L+ Q E S +++ E ++ LK + +E EL Q+
Sbjct: 1128 KLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK 1187
Query: 605 LLKANGEIKHVS---SLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDM 661
L + E+K ++ +L +++K + ++ ++ T L+ +E+ + +K+
Sbjct: 1188 LNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEH 1247
Query: 662 KETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDL--ERQLKTLTKQMKEETE 719
+ETI EL V + + ++ N Q +LE S KL+E+ L E++L K++ E E
Sbjct: 1248 QETIDELRRSVSE-KTAQIINTQ---DLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQE 1303
Query: 720 EWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKE 766
+ + + + + E + K E +E+ L KE
Sbjct: 1304 TMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE 1350
Score = 76.3 bits (186), Expect = 1e-13
Identities = 92/428 (21%), Positives = 201/428 (46%), Gaps = 36/428 (8%)
Query: 370 LASLTEKIQKMEE-NHHSTAEE--LQATLQELSDQQQMVQELTAENEKLVDEKTILETSF 426
++ + EK+ ++++ H A++ LQ+ ++ + +QE E + ++ EK ++
Sbjct: 1540 ISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQ 1599
Query: 427 HQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILE-QGRFEREKLL 485
+ +QL + ++++ ++E + E + + E ++K I + +FE +K L
Sbjct: 1600 EALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQK-L 1658
Query: 486 NIQQQLTCSLR--KVEEENQGALEMIKRLKEENEKLNEFLELERHN-NNMMAKTLEECRV 542
N++ T ++R ++ EN + + + +++ + E L++ER + +T+
Sbjct: 1659 NLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLE 1718
Query: 543 TLEGLKMENGSLKSHLQ----------------GEKQKATEASAVEQTAESCEVQEMLKV 586
E LK+ + LK H + QK E S A+ ++QE L++
Sbjct: 1719 KQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRI 1778
Query: 587 ARAEKDLLELSCNELR----QELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSR 642
A + + ++LR ++ K + K + + AK+++ LK +HQ L +
Sbjct: 1779 AHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELK-ANEHQLITLKK 1837
Query: 643 TSLKLQEKASESD---AEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQ 699
+ Q+K SE + +IKD T+ +LE + + A KLH N + E++ SV+K +
Sbjct: 1838 DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIE-NLNLAQKLHEN--LEEMK-SVMKERDN 1893
Query: 700 KSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEK 759
+E LK Q+KE +E + ++Q + A + E ++ + ++ K+ E+ +
Sbjct: 1894 LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQ 1953
Query: 760 NARLQKEL 767
+ +QK+L
Sbjct: 1954 ISDIQKDL 1961
Score = 72.0 bits (175), Expect = 2e-12
Identities = 138/701 (19%), Positives = 283/701 (40%), Gaps = 119/701 (16%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 221
EK + ++++ L E K E + +LK+ +E + D L ++ T D
Sbjct: 909 EKTLITEKLQQTLEEVKTLTQE----KDDLKQLQESLQIER---DQLKSDIHDTVNMNID 961
Query: 222 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQ 281
T+ +R E K Q+ ++ L+ + + E++ H + G I +
Sbjct: 962 TQEQLRNALESLKQHQETINTLKSK---ISEEVSRNLHMEENTGETKDEFQQKM-VGIDK 1017
Query: 282 ESSFGSPTGNQMSSDID-----EYKKNIHG-----NALRTSGSSSSDVTKASLSPDASDF 331
+ + +++D+ E ++ I N L+ S K L D +
Sbjct: 1018 KQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQM-LESVIAEKEQLKTDLKEN 1076
Query: 332 EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVS---ELS-----LASLTEKIQKMEEN 383
+T E L + K + A +++ ELS LA + EK+++ +
Sbjct: 1077 IEMTIENQEE-LRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQ 1135
Query: 384 HHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL 443
++L +E+S+ Q+ + E+ +L +++ LE + E A++L++ E++
Sbjct: 1136 LQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEV 1195
Query: 444 MNLLQERVKNEE------------------------PTTQEGKI--IELEQKCTGILEQG 477
++ +ER +E T +E KI I L++ I E
Sbjct: 1196 KSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELR 1255
Query: 478 RFEREKLLNI--QQQLTCSLRKVEE------ENQGALEMIKRLKEENEKLNEF------- 522
R EK I Q L S K++E E Q L +K + E E +NE
Sbjct: 1256 RSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQS 1315
Query: 523 ----------LELERHNNN-----------MMAKTLEECRVTLEGLKMENGSLKSHLQGE 561
+E+ER N + K + + E L++++ LK H++
Sbjct: 1316 TTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRET 1375
Query: 562 KQKATEASAVEQTAESCE---------VQEMLKVARAEKDLL--ELSCNELRQELLKANG 610
K E+ + ++ + + + V EM + + LL E+ L + L +++
Sbjct: 1376 LAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHD 1435
Query: 611 EIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELED 670
E+K V AK + D L+E+ +++QL ++ K E++ E+K + E E+
Sbjct: 1436 EMKSV----AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEE 1491
Query: 671 QVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQ-ADLQ 729
+ + R +SE E+ + +++Q + +L+ +++ E+ E++ Q +++Q
Sbjct: 1492 TINELRV-------NLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQ 1544
Query: 730 TAVVVANDIKCEAQQE---LRTVKRKLLEEEEKNARLQKEL 767
V K + + L++++ K+LE + Q+E+
Sbjct: 1545 EKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI 1585
Score = 70.5 bits (171), Expect = 6e-12
Identities = 83/393 (21%), Positives = 176/393 (44%), Gaps = 53/393 (13%)
Query: 389 EELQATLQELSDQQQMVQ-ELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLL 447
+EL T +++ + Q+ Q +L A+ + VD + L+++F+ E KL +L+
Sbjct: 656 KELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFN-----------EITKLTSLI 704
Query: 448 QERVKNEEPTTQE--GKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGA 505
+V + E GKI +L+++ +E+ RE+++ L L+ + E
Sbjct: 705 DGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVI-----LLSELKSLPSE---- 755
Query: 506 LEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKA 565
++RL++E + +E L + + + + ++GL E G K L A
Sbjct: 756 ---VERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL------A 806
Query: 566 TEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE-LRQELLKANGEIKHVSSLLAKVEK 624
T S + T + + + L + +K + L NE + QE++ + E + S L ++
Sbjct: 807 TTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKT 866
Query: 625 DYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQ 684
+ SY + +LQEK E + +M++ +LE++ + V+
Sbjct: 867 ELSYKTQ--------------ELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTL 912
Query: 685 LISELESS---VIKLEEQKSDLERQLKTLT---KQMKEETEEWRRFQADLQTAVVVANDI 738
+ +L+ + V L ++K DL++ ++L Q+K + + D Q + A +
Sbjct: 913 ITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALES 972
Query: 739 KCEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 771
+ Q+ + T+K K+ EE +N +++ G+ +
Sbjct: 973 LKQHQETINTLKSKISEEVSRNLHMEENTGETK 1005
Score = 67.8 bits (164), Expect = 4e-11
Identities = 90/431 (20%), Positives = 190/431 (44%), Gaps = 65/431 (15%)
Query: 386 STAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRE-RAEQLSQENEKLM 444
S E++ +E+ D+ + + +T+E +KL E H+E R + L +E K
Sbjct: 751 SLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVV--------HKESRVQGLLEEIGKTK 802
Query: 445 NLLQERVKNEEPTTQEGKI-----IELEQKCTGILEQGRFEREKLLNIQ---QQLTCSLR 496
+ L N + T QE + ++ EQK +LE+ ++++N+ Q+ SL
Sbjct: 803 DDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLG 862
Query: 497 KVEEE-NQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 555
++ E + E+ ++ +E E+LNE +L+ LE TL+ ++ E +
Sbjct: 863 ALKTELSYKTQELQEKTREVQERLNEMEQLKEQ--------LENRDSTLQTVEREKTLIT 914
Query: 556 SHLQGEKQKATEASAVEQTAESC-EVQEMLKVARAE-----KDLLELSCN---ELRQELL 606
LQ Q E + Q + ++QE L++ R + D + ++ + +LR L
Sbjct: 915 EKLQ---QTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971
Query: 607 KANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIF 666
+ +++L +K+ ++ S + ++ E K+ + D E K+ +
Sbjct: 972 SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTA 1031
Query: 667 ELEDQ--VEQHRAVKL---HNNQLISELESSVIKLEEQKSDL----------ERQLKTLT 711
+++D +EQ R + N+L LES + + E+ K+DL + +L+ L
Sbjct: 1032 DVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLG 1091
Query: 712 KQMKEETE-----------EWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKN 760
++K++ E + V +K E Q+L+ +++LL +E+
Sbjct: 1092 DELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLK-EKSQQLQEKQQQLLNVQEEM 1150
Query: 761 ARLQKELGDVQ 771
+ +QK++ +++
Sbjct: 1151 SEMQKKINEIE 1161
Score = 60.1 bits (144), Expect = 8e-09
Identities = 87/420 (20%), Positives = 187/420 (44%), Gaps = 42/420 (10%)
Query: 367 ELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSF 426
E S A L EKIQ+++ N H +L +++++ Q+ V E+ +++ D+ L
Sbjct: 1812 ENSNAKLQEKIQELKANEH----QLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLE 1867
Query: 427 HQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLN 486
++ A++L + E++ ++++ER + +E +E +Q + E + + + L
Sbjct: 1868 IENLNLAQKLHENLEEMKSVMKER--DNLRRVEETLKLERDQ----LKESLQETKARDLE 1921
Query: 487 IQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEF-LELERHNNNMMAKTLEECRVTLE 545
IQQ+L + +E + ++ +++ E+ ++++ +L++ + + K E + L+
Sbjct: 1922 IQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQ 1981
Query: 546 GLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEM-LKVARAEKDLLELSCNELRQE 604
L+++ SH + + +EQ + E Q + ++ R + L +E +E
Sbjct: 1982 LLRVKEDVNMSH--------KKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEE 2033
Query: 605 L---LKANGEIKHVSSLLAKVEKD--YSYLKEIC--DHQAEQ-------LSRTSLKLQEK 650
+ K E++ + L K+E+D + L+E+ D Q Q LS L E
Sbjct: 2034 IRIVAKERDELRRIKESL-KMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTES 2092
Query: 651 ASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTL 710
E + IK++ + E++D E + L + I + ++++ S Q K +
Sbjct: 2093 LREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHI 2152
Query: 711 TKQMKEE---TEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKEL 767
K + E+ R L+ + IK E + + + ++E EK QKEL
Sbjct: 2153 EKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEK----QKEL 2208
Score = 54.3 bits (129), Expect = 4e-07
Identities = 95/452 (21%), Positives = 195/452 (43%), Gaps = 44/452 (9%)
Query: 353 SKCSTAGSSPNSVSELSLASLTEKIQKM-EENHHSTAEELQATLQEL--------SDQQQ 403
S CS + N++ LS + + +EN S L+A L +++++
Sbjct: 464 SVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEE 523
Query: 404 MVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQE-RVKNEEPTTQEGK 462
M +L +N+ +DE LE + +E QL E L NL++ V N++ +
Sbjct: 524 MELKLKEKND--LDEFEALERKTKKDQEM--QLIHEISNLKNLVKHAEVYNQDLENELSS 579
Query: 463 IIELEQKCTGILE--QGRFEREKLLNIQQQLTCSLRKVEEENQGALEMI---------KR 511
+EL ++ ++ Q + +KL NI+ L+ SL +E+ Q + KR
Sbjct: 580 KVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKR 639
Query: 512 ----LKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATE 567
L+ EN +L E ++ M ++ + LE K L+ LQ + T+
Sbjct: 640 ESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITK 699
Query: 568 ASAVEQTAES----CEVQEMLKVARAEKDL-LELSCNE-LRQELLKANGEIKHVSSLLAK 621
+++ C ++ K+ +K+L E+ NE LR+E++ + + SL ++
Sbjct: 700 LTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVIL----LSELKSLPSE 755
Query: 622 VEKDYSYLKEICDHQAEQLSRTSL--KLQEKASESDAEIKDMKETIFELEDQVEQHRAVK 679
VE+ KEI D E TS KL + ++ ++ + E I + +D + ++
Sbjct: 756 VER---LRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNY 812
Query: 680 LHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIK 739
+Q ++ + E++ + + + + +++ ++E ++F + L +
Sbjct: 813 KSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKT 872
Query: 740 CEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 771
E Q++ R V+ +L E E+ +L+ +Q
Sbjct: 873 QELQEKTREVQERLNEMEQLKEQLENRDSTLQ 904
Score = 46.2 bits (108), Expect = 1e-04
Identities = 74/364 (20%), Positives = 146/364 (40%), Gaps = 50/364 (13%)
Query: 377 IQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQL 436
+ K++E H + + + + E+ + E L+ + + + RE +
Sbjct: 2180 VTKIKEEQHESINKFE---------MDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLK 2230
Query: 437 SQENEKLM--NLLQERVKNEEPT--TQEGKIIELEQKCTGILEQG---RFEREKLLNIQQ 489
+N L +L++ ++E P+ T+ +++ ++ T LE+ RF+ EKL N Q
Sbjct: 2231 LNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQ 2290
Query: 490 QLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKM 549
+ + +V + I +NE E E + A +E L+ LK
Sbjct: 2291 KENDRICQVNNFFNNRIIAI---------MNESTEFEERS----ATISKEWEQDLKSLKE 2337
Query: 550 ENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKAN 609
+N L + Q K + V T + + V L EL L +A
Sbjct: 2338 KNEKLFKNYQTLKTSLASGAQVNPTTQD---NKNPHVTSRATQLTTEKIRELENSLHEAK 2394
Query: 610 GEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELE 669
H S + K++K+ +I KLQ K ES+ ++ KETI L+
Sbjct: 2395 ESAMHKESKIIKMQKELEVTNDII-----------AKLQAKVHESNKCLEKTKETIQVLQ 2443
Query: 670 DQVEQHRAVKLHNNQLISELESSVIKLEEQK----SDLERQLKTLTKQMKEETEEWRRFQ 725
D+V K + + I +L+ ++K++ +K + E+++ ++ + E R +
Sbjct: 2444 DKVA--LGAKPYKEE-IEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLR 2500
Query: 726 ADLQ 729
+L+
Sbjct: 2501 ENLR 2504
Score = 36.2 bits (82), Expect = 0.12
Identities = 86/423 (20%), Positives = 157/423 (37%), Gaps = 71/423 (16%)
Query: 404 MVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKI 463
+ +E+ +E + T E S H + Q S + + ++ E + EP+ EG +
Sbjct: 167 LTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSV 226
Query: 464 IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGAL---EMIKRLKE------ 514
+ R + ++ + C++ N+ ++IK+L +
Sbjct: 227 KVSHLNLVDLAGSERAAQTGAAGVRLKEGCNI------NRSLFILGQVIKKLSDGQVGGF 280
Query: 515 ---ENEKLNEFLELERHNNNMMAKTLEECRVT---------------------------- 543
+ KL L+ N AKT C +T
Sbjct: 281 INYRDSKLTRILQNSLGGN---AKTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNE 337
Query: 544 -------LEGLKMENGSLKSHLQGEKQKATEASAVE--QTAESCEVQEMLKVARAEK--- 591
L+ + E LK L+ E T A A+E Q A+ E +++L+ + EK
Sbjct: 338 VSTDEALLKRYRKEIMDLKKQLE-EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIEN 396
Query: 592 --DLLELSCNELRQELLKANGEIKHVSSLLAKVEK----DYSYLKEICDHQAEQLSRTSL 645
+L S + Q+ LKA + + V+ L K+ K +Y+ I + + + S+
Sbjct: 397 LTRMLVTSSSLTLQQELKAKRK-RRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSI 455
Query: 646 KLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLI-SELESSVIKLEEQKSDLE 704
L + ES D+ + ++E + A KL N + I SEL S + D E
Sbjct: 456 NLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYE 515
Query: 705 RQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQ 764
QL+T ++M+ + +E D + + E+ +K + E N L+
Sbjct: 516 -QLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLE 574
Query: 765 KEL 767
EL
Sbjct: 575 NEL 577
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 92.8 bits (229), Expect = 1e-18
Identities = 139/617 (22%), Positives = 252/617 (40%), Gaps = 103/617 (16%)
Query: 221 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN---------SEGA--ASH 269
+TE + ++E+ + + EL+ E + + L+EK++ L N +EG A
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 270 TGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 329
D T I E+ T + + D +E NA T+ + + L D
Sbjct: 910 RCDQLIKTKIQLEAKIKEVT--ERAEDEEEI------NAELTAKKRKLEDECSELKKDID 961
Query: 330 DFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAE 389
D E +T + +T N K+ AG + ++A LT++ + ++E H T +
Sbjct: 962 DLE-LTLAKVEKEKHATENKVKNLTEEMAG------LDETIAKLTKEKKALQEAHQQTLD 1014
Query: 390 ELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL---MNL 446
+LQA ++ V LT KL + LE S Q ++ L + KL + L
Sbjct: 1015 DLQA-------EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL 1067
Query: 447 LQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGAL 506
QE + + E Q +L++K L++ FE + N+Q K+E+E +
Sbjct: 1068 AQESIMDIENEKQ-----QLDEK----LKKKEFE---ISNLQS-------KIEDEQALGI 1108
Query: 507 EMIKRLKE---ENEKLNEFLELER-------HNNNMMAKTLEECRVTLEGLKMENGSLKS 556
++ K++KE E+L E +E ER + +++ LEE E L+ G+ +
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS---ERLEEAGGATSA 1165
Query: 557 HLQGEKQKATEASAVEQTAESCEVQEMLKVARAEK-------------DLLELSCNELRQ 603
++ K++ E + + E +Q A K D L+ +L +
Sbjct: 1166 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225
Query: 604 ELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKE 663
E + EI ++S + V K L+++C +QLS +L+ K E I D+
Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLS----ELKSKEEEQQRLINDLTA 1281
Query: 664 TIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ---------- 713
L+ + + L+S+L +Q +L+RQL+ K
Sbjct: 1282 QRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQS 1341
Query: 714 -------MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEE-EEKNARLQK 765
++E+ EE + +A+LQ A+ AN + + + T + EE EE +L +
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1401
Query: 766 ELGDVQGHGRVVTSRAA 782
L + H V ++ A
Sbjct: 1402 RLQAAEEHVEAVNAKCA 1418
Score = 81.3 bits (199), Expect = 3e-15
Identities = 137/633 (21%), Positives = 254/633 (40%), Gaps = 81/633 (12%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 221
EK AL+ ++ L + +A++ ++N L K +++ D L +++ D
Sbjct: 1001 EKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQ-------VDDLEGSLEQEKKLRMD 1053
Query: 222 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQ 281
E R LE K Q+ + D+E E + L EKL E S+ + I
Sbjct: 1054 LERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEI-----------SNLQSKIED 1102
Query: 282 ESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSR 341
E + G Q+ I E + I +S +A SD SR
Sbjct: 1103 EQALGI----QLQKKIKELQARIEELEEEIEAERAS---RAKAEKQRSDL--------SR 1147
Query: 342 PLSSTSNPFKSSKCSTAGS-SPNSVSELSLASLTEKIQKMEENHHSTAEELQAT-LQELS 399
L S + + +T+ N E + +++ H +TA L+ ++
Sbjct: 1148 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVA 1207
Query: 400 DQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQEN---EKLMNLLQERVKNEEP 456
+ + + L +KL EK+ ++ E +S+ EK+ L++++ +
Sbjct: 1208 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS 1267
Query: 457 TTQEGKIIELE---QKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLK 513
+E + + + Q+ E G F R+ L+ ++ L L + ++ +E +KR
Sbjct: 1268 KEEEQQRLINDLTAQRGRLQTESGEFSRQ--LDEKEALVSQLSRGKQAFTQQIEELKRQL 1325
Query: 514 EENEK----LNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKA-TEA 568
EE K L L+ RH+ +++ + EE + + K+ LQ KA TE
Sbjct: 1326 EEEIKAKNALAHALQSSRHDCDLLREQYEEEQES-----------KAELQRALSKANTEV 1374
Query: 569 SAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSY 628
+ E+ +Q ++ A+K +L Q L A ++ V++ A +EK
Sbjct: 1375 AQWRTKYETDAIQRTEELEEAKK--------KLAQRLQAAEEHVEAVNAKCASLEKTKQR 1426
Query: 629 LKEICDHQAEQLSRTSLK---LQEKASESDAEIKDMK----ETIFELEDQVEQHRAVKLH 681
L+ + + RT+ L +K D + + K ET ELE ++ R++
Sbjct: 1427 LQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTE 1486
Query: 682 NNQLISELESSVIKLEEQKSD---LERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDI 738
++ + E S+ +LE K + L++++ LT+Q+ E + +L+
Sbjct: 1487 LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH----ELEKIKKQVEQE 1542
Query: 739 KCEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 771
KCE Q L + L EE K R+Q EL V+
Sbjct: 1543 KCELQAALEEAEASLEHEEGKILRIQLELNQVK 1575
Score = 76.3 bits (186), Expect = 1e-13
Identities = 133/640 (20%), Positives = 251/640 (39%), Gaps = 94/640 (14%)
Query: 145 KHLRTPSTKPKQENEGGEKAA------LESQVRELLAEAKAKDSEINRLRSELKKYKEKR 198
K LR + K++ EG K A +E++ ++L + K K+ EI+ L+S K ++++
Sbjct: 1048 KKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS---KIEDEQ 1104
Query: 199 TLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLE 258
L + L + + E I A +K+ SDL E + E+L
Sbjct: 1105 ALGIQ----LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL---- 1156
Query: 259 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSD 318
+ GA S + + +E+ F +M D++E A +
Sbjct: 1157 --EEAGGATS----AQIEMNKKREAEF-----QKMRRDLEEATLQHEATAATLRKKHADS 1205
Query: 319 VTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQ 378
V A L + + + + S + LAS E +
Sbjct: 1206 V--AELGEQIDNLQRVKQKLEKE------------------KSEMKMEIDDLASNVETVS 1245
Query: 379 KMEENHHSTAEELQATLQELS----DQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 434
K + N L+ L EL +QQ+++ +LTA+ +L E +
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVS 1305
Query: 435 QLS-------QENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNI 487
QLS Q+ E+L L+E +K + + C + EQ E+E +
Sbjct: 1306 QLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA--LQSSRHDCDLLREQYEEEQESKAEL 1363
Query: 488 QQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGL 547
Q+ L+ + +V + R K E + + ELE + A+ L+ +E +
Sbjct: 1364 QRALSKANTEVAQW---------RTKYETDAIQRTEELEEAKKKL-AQRLQAAEEHVEAV 1413
Query: 548 KMENGSLKSHLQGEKQKATEASA-VEQTAESCEVQEMLKVARAEKDLLELS--CNELRQE 604
+ SL+ Q + + + VE+T +C + K +K L E C E E
Sbjct: 1414 NAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK-KQRNFDKILAEWKQKCEETHAE 1472
Query: 605 LLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKET 664
L + E + + + L K++ Y +E D Q E L R + LQ++ S+ +I + +
Sbjct: 1473 LEASQKEARSLGTELFKIKNAY---EESLD-QLETLKRENKNLQQEISDLTEQIAEGGKR 1528
Query: 665 IFELEDQVEQHRAVKLHNNQLISELESSV-----------IKLEEQKSDLERQLKTLTKQ 713
I ELE +Q K + E E+S+ ++L + KS+++R++ +
Sbjct: 1529 IHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI----AE 1584
Query: 714 MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKL 753
EE ++ +R + ++ D + ++ + +K+K+
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKM 1624
Score = 73.9 bits (180), Expect = 5e-13
Identities = 95/406 (23%), Positives = 175/406 (43%), Gaps = 60/406 (14%)
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 435
K + E+ + EE Q EL+ + +EL + L+ EK L+ Q + AE
Sbjct: 847 KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL---QVQAEAEG 903
Query: 436 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 495
L+ E+ L++ + I+LE K + E+ E E I +LT
Sbjct: 904 LADAEERCDQLIKTK-------------IQLEAKIKEVTERAEDEEE----INAELTAKK 946
Query: 496 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 555
RK+E+E +K+ ++ E +E E+H K L E L+ + K
Sbjct: 947 RKLEDE----CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK 1002
Query: 556 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDL---LELSCNELRQELLKAN--- 609
LQ Q+ + E+ + + +K+ + DL LE +LR +L +A
Sbjct: 1003 KALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE-KKLRMDLERAKRKL 1061
Query: 610 -GEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKAS---ESDAEIKDMKETI 665
G++K + +E + L E + ++S K++++ + + +IK+++ I
Sbjct: 1062 EGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI 1121
Query: 666 FELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQ 725
ELE+++E RA S K E+Q+SDL R+L+ ++++++E
Sbjct: 1122 EELEEEIEAERA--------------SRAKAEKQRSDLSRELEEISERLEE--------- 1158
Query: 726 ADLQTAVVVANDIKCEA--QQELRTVKRKLLEEEEKNARLQKELGD 769
A T+ + + K EA Q+ R ++ L+ E A L+K+ D
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Score = 62.8 bits (151), Expect = 1e-09
Identities = 75/303 (24%), Positives = 133/303 (43%), Gaps = 56/303 (18%)
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 554
L+ E E + A +KEE +K+ + E + K LEE VTL LK +N L
Sbjct: 846 LKSAETEKEMAT-----MKEEFQKIKD----ELAKSEAKRKELEEKMVTL--LKEKN-DL 893
Query: 555 KSHLQGEKQKATEA---------------SAVEQTAESCEVQEMLKVA-RAEKDLLELSC 598
+ +Q E + +A + +++ E E +E + A+K LE C
Sbjct: 894 QLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 953
Query: 599 NELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEI 658
+EL+++ I + LAKVEK+ K +++ + L+ L E ++ E
Sbjct: 954 SELKKD-------IDDLELTLAKVEKE----KHATENKVKNLTEEMAGLDETIAKLTKEK 1002
Query: 659 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 718
K ++E + D ++ ++ L + IKLE+Q DLE L+ K +
Sbjct: 1003 KALQEAHQQTLDDLQAEE-------DKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1055
Query: 719 EEWRRFQADLQTAVVVANDIKCEAQQ----------ELRTVKRKLLEEEEKNARLQKELG 768
R+ + DL+ A DI+ E QQ E+ ++ K+ +E+ +LQK++
Sbjct: 1056 RAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIK 1115
Query: 769 DVQ 771
++Q
Sbjct: 1116 ELQ 1118
Score = 58.9 bits (141), Expect = 2e-08
Identities = 125/634 (19%), Positives = 235/634 (37%), Gaps = 111/634 (17%)
Query: 129 RKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEA-KAKDSEINRL 187
++++S + TK+ + ++ E +K A Q E EA AK + + +
Sbjct: 1364 QRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT 1423
Query: 188 RSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEEN 247
+ L+ E L+ E T+A AL++K +NF K L++ +++
Sbjct: 1424 KQRLQNEVEDLMLDVERTNAA-----------------CAALDKKQRNFDKILAEWKQKC 1466
Query: 248 RVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGN------QMSSDIDEYK 301
+L + S G ++ S+ Q + N ++ I E
Sbjct: 1467 EETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGG 1526
Query: 302 KNIHG-NALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS 360
K IH ++ +A+L + EH E + N KS
Sbjct: 1527 KRIHELEKIKKQVEQEKCELQAALEEAEASLEH--EEGKILRIQLELNQVKSEV------ 1578
Query: 361 SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQ---------------------ELS 399
+ +A E+I +++ NH E +Q+TL E+
Sbjct: 1579 ------DRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1632
Query: 400 DQQQMVQELTAENEK--------LVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERV 451
Q + AE + L D + L+ + + EQL+ E+ NLLQ +
Sbjct: 1633 IQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV-ERRANLLQAEI 1691
Query: 452 KNEEPTTQEGKIIELEQKCTGILEQGRF---EREKLLNIQQQLTCSLRKVEEENQGALEM 508
+ T +E ++ I EQ ER +LL+ Q + +K E +
Sbjct: 1692 EELRAT------LEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD------ 1739
Query: 509 IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEA 568
+ + ++ + L+ R+ K + + + E LK E + +HL+ K+
Sbjct: 1740 ---ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDT-SAHLERMKKN---- 1791
Query: 569 SAVEQTAESCEV------QEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKV 622
+EQT + ++ Q LK + + LE EL E+ E K + + +
Sbjct: 1792 --MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEV---ESEQKRNAEAVKGL 1846
Query: 623 EKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHN 682
K +KE+ +Q E+ + L+LQ+ + A++K K E E+Q + A
Sbjct: 1847 RKHERRVKELT-YQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLA----- 1900
Query: 683 NQLISELESSVIKLEEQKSDLERQLKTLTKQMKE 716
+L+ + + EE+ E Q+ L + +E
Sbjct: 1901 --KFRKLQHELEEAEERADIAESQVNKLRVKSRE 1932
Score = 58.5 bits (140), Expect = 2e-08
Identities = 126/652 (19%), Positives = 259/652 (39%), Gaps = 88/652 (13%)
Query: 166 LESQVRELLAEAKAKDSEINRLRSEL-------KKYKEKRTLNAEGTDALGPNVDGTSVS 218
+E R+L E KAK++ + L+S ++Y+E++ AE AL T V+
Sbjct: 1318 IEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKA--NTEVA 1375
Query: 219 PGDTEPMIRA------LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGD 272
T+ A LEE K + L EE + K LE + + + D
Sbjct: 1376 QWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT--KQRLQNEVED 1433
Query: 273 SSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFE 332
T N + +D+ ++N + + + T A L +
Sbjct: 1434 LMLDVERT----------NAACAALDKKQRNF--DKILAEWKQKCEETHAELEASQKEAR 1481
Query: 333 HITAETPSRPLSSTSNPFKSSKCSTAG-SSPNSVSELSLASLTEKIQKMEENHHSTAEEL 391
+ E L N ++ S N + ++ LTE+I + + H +
Sbjct: 1482 SLGTE-----LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIK 1536
Query: 392 QATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE---QLSQENEKLMNLLQ 448
+ QE + Q ++E A E +E IL ++ ++E ++++++E++ L +
Sbjct: 1537 KQVEQEKCELQAALEEAEASLEH--EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR 1594
Query: 449 ERVKNEEP--TTQEGKI------IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEE 500
++ E +T + +I I L++K G L E E LN ++ +
Sbjct: 1595 NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN----EMEIQLNHANRMAAEALRNYR 1650
Query: 501 ENQGALE----MIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKS 556
QG L+ + E L E L + N++ +EE R TLE + +
Sbjct: 1651 NTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1710
Query: 557 HLQGEKQKA----TEASAVEQTAESCE---------VQEMLKVARAEKDLLELSCNE--- 600
L ++ T+ +++ T + E ++++L+ AR ++ + + +
Sbjct: 1711 ELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAM 1770
Query: 601 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLS-----RTSLKLQEKASESD 655
+ +EL K H+ + +E+ L+ D +AEQL+ + KL+ + E +
Sbjct: 1771 MAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLD-EAEQLALKGGKKQIQKLEARVRELE 1829
Query: 656 AEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK 715
E++ ++ E + +H E ++++L++ L+ ++K+ +Q +
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1889
Query: 716 EETEE-------WRRFQADLQTAVVVANDIKCEAQQ---ELRTVKRKLLEEE 757
E E+ +R+ Q +L+ A A+ + + + + R V K++ EE
Sbjct: 1890 EAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 92.8 bits (229), Expect = 1e-18
Identities = 139/617 (22%), Positives = 252/617 (40%), Gaps = 103/617 (16%)
Query: 221 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN---------SEGA--ASH 269
+TE + ++E+ + + EL+ E + + L+EK++ L N +EG A
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 270 TGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 329
D T I E+ T + + D +E NA T+ + + L D
Sbjct: 910 RCDQLIKTKIQLEAKIKEVT--ERAEDEEEI------NAELTAKKRKLEDECSELKKDID 961
Query: 330 DFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAE 389
D E +T + +T N K+ AG + ++A LT++ + ++E H T +
Sbjct: 962 DLE-LTLAKVEKEKHATENKVKNLTEEMAG------LDETIAKLTKEKKALQEAHQQTLD 1014
Query: 390 ELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL---MNL 446
+LQA ++ V LT KL + LE S Q ++ L + KL + L
Sbjct: 1015 DLQA-------EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL 1067
Query: 447 LQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGAL 506
QE + + E Q +L++K L++ FE + N+Q K+E+E +
Sbjct: 1068 AQESIMDIENEKQ-----QLDEK----LKKKEFE---ISNLQS-------KIEDEQALGI 1108
Query: 507 EMIKRLKE---ENEKLNEFLELER-------HNNNMMAKTLEECRVTLEGLKMENGSLKS 556
++ K++KE E+L E +E ER + +++ LEE E L+ G+ +
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS---ERLEEAGGATSA 1165
Query: 557 HLQGEKQKATEASAVEQTAESCEVQEMLKVARAEK-------------DLLELSCNELRQ 603
++ K++ E + + E +Q A K D L+ +L +
Sbjct: 1166 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225
Query: 604 ELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKE 663
E + EI ++S + V K L+++C +QLS +L+ K E I D+
Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLS----ELKSKEEEQQRLINDLTA 1281
Query: 664 TIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ---------- 713
L+ + + L+S+L +Q +L+RQL+ K
Sbjct: 1282 QRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQS 1341
Query: 714 -------MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEE-EEKNARLQK 765
++E+ EE + +A+LQ A+ AN + + + T + EE EE +L +
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1401
Query: 766 ELGDVQGHGRVVTSRAA 782
L + H V ++ A
Sbjct: 1402 RLQAAEEHVEAVNAKCA 1418
Score = 81.3 bits (199), Expect = 3e-15
Identities = 137/633 (21%), Positives = 254/633 (40%), Gaps = 81/633 (12%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 221
EK AL+ ++ L + +A++ ++N L K +++ D L +++ D
Sbjct: 1001 EKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQ-------VDDLEGSLEQEKKLRMD 1053
Query: 222 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQ 281
E R LE K Q+ + D+E E + L EKL E S+ + I
Sbjct: 1054 LERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEI-----------SNLQSKIED 1102
Query: 282 ESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSR 341
E + G Q+ I E + I +S +A SD SR
Sbjct: 1103 EQALGI----QLQKKIKELQARIEELEEEIEAERAS---RAKAEKQRSDL--------SR 1147
Query: 342 PLSSTSNPFKSSKCSTAGS-SPNSVSELSLASLTEKIQKMEENHHSTAEELQAT-LQELS 399
L S + + +T+ N E + +++ H +TA L+ ++
Sbjct: 1148 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVA 1207
Query: 400 DQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQEN---EKLMNLLQERVKNEEP 456
+ + + L +KL EK+ ++ E +S+ EK+ L++++ +
Sbjct: 1208 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS 1267
Query: 457 TTQEGKIIELE---QKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLK 513
+E + + + Q+ E G F R+ L+ ++ L L + ++ +E +KR
Sbjct: 1268 KEEEQQRLINDLTAQRGRLQTESGEFSRQ--LDEKEALVSQLSRGKQAFTQQIEELKRQL 1325
Query: 514 EENEK----LNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKA-TEA 568
EE K L L+ RH+ +++ + EE + + K+ LQ KA TE
Sbjct: 1326 EEEIKAKNALAHALQSSRHDCDLLREQYEEEQES-----------KAELQRALSKANTEV 1374
Query: 569 SAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSY 628
+ E+ +Q ++ A+K +L Q L A ++ V++ A +EK
Sbjct: 1375 AQWRTKYETDAIQRTEELEEAKK--------KLAQRLQAAEEHVEAVNAKCASLEKTKQR 1426
Query: 629 LKEICDHQAEQLSRTSLK---LQEKASESDAEIKDMK----ETIFELEDQVEQHRAVKLH 681
L+ + + RT+ L +K D + + K ET ELE ++ R++
Sbjct: 1427 LQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTE 1486
Query: 682 NNQLISELESSVIKLEEQKSD---LERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDI 738
++ + E S+ +LE K + L++++ LT+Q+ E + +L+
Sbjct: 1487 LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH----ELEKIKKQVEQE 1542
Query: 739 KCEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 771
KCE Q L + L EE K R+Q EL V+
Sbjct: 1543 KCELQAALEEAEASLEHEEGKILRIQLELNQVK 1575
Score = 76.3 bits (186), Expect = 1e-13
Identities = 133/640 (20%), Positives = 251/640 (39%), Gaps = 94/640 (14%)
Query: 145 KHLRTPSTKPKQENEGGEKAA------LESQVRELLAEAKAKDSEINRLRSELKKYKEKR 198
K LR + K++ EG K A +E++ ++L + K K+ EI+ L+S K ++++
Sbjct: 1048 KKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS---KIEDEQ 1104
Query: 199 TLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLE 258
L + L + + E I A +K+ SDL E + E+L
Sbjct: 1105 ALGIQ----LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL---- 1156
Query: 259 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSD 318
+ GA S + + +E+ F +M D++E A +
Sbjct: 1157 --EEAGGATS----AQIEMNKKREAEF-----QKMRRDLEEATLQHEATAATLRKKHADS 1205
Query: 319 VTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQ 378
V A L + + + + S + LAS E +
Sbjct: 1206 V--AELGEQIDNLQRVKQKLEKE------------------KSEMKMEIDDLASNVETVS 1245
Query: 379 KMEENHHSTAEELQATLQELS----DQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 434
K + N L+ L EL +QQ+++ +LTA+ +L E +
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVS 1305
Query: 435 QLS-------QENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNI 487
QLS Q+ E+L L+E +K + + C + EQ E+E +
Sbjct: 1306 QLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA--LQSSRHDCDLLREQYEEEQESKAEL 1363
Query: 488 QQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGL 547
Q+ L+ + +V + R K E + + ELE + A+ L+ +E +
Sbjct: 1364 QRALSKANTEVAQW---------RTKYETDAIQRTEELEEAKKKL-AQRLQAAEEHVEAV 1413
Query: 548 KMENGSLKSHLQGEKQKATEASA-VEQTAESCEVQEMLKVARAEKDLLELS--CNELRQE 604
+ SL+ Q + + + VE+T +C + K +K L E C E E
Sbjct: 1414 NAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK-KQRNFDKILAEWKQKCEETHAE 1472
Query: 605 LLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKET 664
L + E + + + L K++ Y +E D Q E L R + LQ++ S+ +I + +
Sbjct: 1473 LEASQKEARSLGTELFKIKNAY---EESLD-QLETLKRENKNLQQEISDLTEQIAEGGKR 1528
Query: 665 IFELEDQVEQHRAVKLHNNQLISELESSV-----------IKLEEQKSDLERQLKTLTKQ 713
I ELE +Q K + E E+S+ ++L + KS+++R++ +
Sbjct: 1529 IHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI----AE 1584
Query: 714 MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKL 753
EE ++ +R + ++ D + ++ + +K+K+
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKM 1624
Score = 73.9 bits (180), Expect = 5e-13
Identities = 95/406 (23%), Positives = 175/406 (43%), Gaps = 60/406 (14%)
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 435
K + E+ + EE Q EL+ + +EL + L+ EK L+ Q + AE
Sbjct: 847 KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL---QVQAEAEG 903
Query: 436 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 495
L+ E+ L++ + I+LE K + E+ E E I +LT
Sbjct: 904 LADAEERCDQLIKTK-------------IQLEAKIKEVTERAEDEEE----INAELTAKK 946
Query: 496 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 555
RK+E+E +K+ ++ E +E E+H K L E L+ + K
Sbjct: 947 RKLEDE----CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK 1002
Query: 556 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDL---LELSCNELRQELLKAN--- 609
LQ Q+ + E+ + + +K+ + DL LE +LR +L +A
Sbjct: 1003 KALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE-KKLRMDLERAKRKL 1061
Query: 610 -GEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKAS---ESDAEIKDMKETI 665
G++K + +E + L E + ++S K++++ + + +IK+++ I
Sbjct: 1062 EGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI 1121
Query: 666 FELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQ 725
ELE+++E RA S K E+Q+SDL R+L+ ++++++E
Sbjct: 1122 EELEEEIEAERA--------------SRAKAEKQRSDLSRELEEISERLEE--------- 1158
Query: 726 ADLQTAVVVANDIKCEA--QQELRTVKRKLLEEEEKNARLQKELGD 769
A T+ + + K EA Q+ R ++ L+ E A L+K+ D
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Score = 62.8 bits (151), Expect = 1e-09
Identities = 75/303 (24%), Positives = 133/303 (43%), Gaps = 56/303 (18%)
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 554
L+ E E + A +KEE +K+ + E + K LEE VTL LK +N L
Sbjct: 846 LKSAETEKEMAT-----MKEEFQKIKD----ELAKSEAKRKELEEKMVTL--LKEKN-DL 893
Query: 555 KSHLQGEKQKATEA---------------SAVEQTAESCEVQEMLKVA-RAEKDLLELSC 598
+ +Q E + +A + +++ E E +E + A+K LE C
Sbjct: 894 QLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 953
Query: 599 NELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEI 658
+EL+++ I + LAKVEK+ K +++ + L+ L E ++ E
Sbjct: 954 SELKKD-------IDDLELTLAKVEKE----KHATENKVKNLTEEMAGLDETIAKLTKEK 1002
Query: 659 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 718
K ++E + D ++ ++ L + IKLE+Q DLE L+ K +
Sbjct: 1003 KALQEAHQQTLDDLQAEE-------DKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1055
Query: 719 EEWRRFQADLQTAVVVANDIKCEAQQ----------ELRTVKRKLLEEEEKNARLQKELG 768
R+ + DL+ A DI+ E QQ E+ ++ K+ +E+ +LQK++
Sbjct: 1056 RAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIK 1115
Query: 769 DVQ 771
++Q
Sbjct: 1116 ELQ 1118
Score = 58.9 bits (141), Expect = 2e-08
Identities = 125/634 (19%), Positives = 235/634 (37%), Gaps = 111/634 (17%)
Query: 129 RKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEA-KAKDSEINRL 187
++++S + TK+ + ++ E +K A Q E EA AK + + +
Sbjct: 1364 QRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT 1423
Query: 188 RSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEEN 247
+ L+ E L+ E T+A AL++K +NF K L++ +++
Sbjct: 1424 KQRLQNEVEDLMLDVERTNAA-----------------CAALDKKQRNFDKILAEWKQKC 1466
Query: 248 RVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGN------QMSSDIDEYK 301
+L + S G ++ S+ Q + N ++ I E
Sbjct: 1467 EETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGG 1526
Query: 302 KNIHG-NALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS 360
K IH ++ +A+L + EH E + N KS
Sbjct: 1527 KRIHELEKIKKQVEQEKCELQAALEEAEASLEH--EEGKILRIQLELNQVKSEV------ 1578
Query: 361 SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQ---------------------ELS 399
+ +A E+I +++ NH E +Q+TL E+
Sbjct: 1579 ------DRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1632
Query: 400 DQQQMVQELTAENEK--------LVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERV 451
Q + AE + L D + L+ + + EQL+ E+ NLLQ +
Sbjct: 1633 IQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV-ERRANLLQAEI 1691
Query: 452 KNEEPTTQEGKIIELEQKCTGILEQGRF---EREKLLNIQQQLTCSLRKVEEENQGALEM 508
+ T +E ++ I EQ ER +LL+ Q + +K E +
Sbjct: 1692 EELRAT------LEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD------ 1739
Query: 509 IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEA 568
+ + ++ + L+ R+ K + + + E LK E + +HL+ K+
Sbjct: 1740 ---ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDT-SAHLERMKKN---- 1791
Query: 569 SAVEQTAESCEV------QEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKV 622
+EQT + ++ Q LK + + LE EL E+ E K + + +
Sbjct: 1792 --MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEV---ESEQKRNAEAVKGL 1846
Query: 623 EKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHN 682
K +KE+ +Q E+ + L+LQ+ + A++K K E E+Q + A
Sbjct: 1847 RKHERRVKELT-YQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLA----- 1900
Query: 683 NQLISELESSVIKLEEQKSDLERQLKTLTKQMKE 716
+L+ + + EE+ E Q+ L + +E
Sbjct: 1901 --KFRKLQHELEEAEERADIAESQVNKLRVKSRE 1932
Score = 58.5 bits (140), Expect = 2e-08
Identities = 126/652 (19%), Positives = 259/652 (39%), Gaps = 88/652 (13%)
Query: 166 LESQVRELLAEAKAKDSEINRLRSEL-------KKYKEKRTLNAEGTDALGPNVDGTSVS 218
+E R+L E KAK++ + L+S ++Y+E++ AE AL T V+
Sbjct: 1318 IEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKA--NTEVA 1375
Query: 219 PGDTEPMIRA------LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGD 272
T+ A LEE K + L EE + K LE + + + D
Sbjct: 1376 QWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT--KQRLQNEVED 1433
Query: 273 SSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFE 332
T N + +D+ ++N + + + T A L +
Sbjct: 1434 LMLDVERT----------NAACAALDKKQRNF--DKILAEWKQKCEETHAELEASQKEAR 1481
Query: 333 HITAETPSRPLSSTSNPFKSSKCSTAG-SSPNSVSELSLASLTEKIQKMEENHHSTAEEL 391
+ E L N ++ S N + ++ LTE+I + + H +
Sbjct: 1482 SLGTE-----LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIK 1536
Query: 392 QATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE---QLSQENEKLMNLLQ 448
+ QE + Q ++E A E +E IL ++ ++E ++++++E++ L +
Sbjct: 1537 KQVEQEKCELQAALEEAEASLEH--EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR 1594
Query: 449 ERVKNEEP--TTQEGKI------IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEE 500
++ E +T + +I I L++K G L E E LN ++ +
Sbjct: 1595 NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN----EMEIQLNHANRMAAEALRNYR 1650
Query: 501 ENQGALE----MIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKS 556
QG L+ + E L E L + N++ +EE R TLE + +
Sbjct: 1651 NTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1710
Query: 557 HLQGEKQKA----TEASAVEQTAESCE---------VQEMLKVARAEKDLLELSCNE--- 600
L ++ T+ +++ T + E ++++L+ AR ++ + + +
Sbjct: 1711 ELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAM 1770
Query: 601 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLS-----RTSLKLQEKASESD 655
+ +EL K H+ + +E+ L+ D +AEQL+ + KL+ + E +
Sbjct: 1771 MAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLD-EAEQLALKGGKKQIQKLEARVRELE 1829
Query: 656 AEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK 715
E++ ++ E + +H E ++++L++ L+ ++K+ +Q +
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1889
Query: 716 EETEE-------WRRFQADLQTAVVVANDIKCEAQQ---ELRTVKRKLLEEE 757
E E+ +R+ Q +L+ A A+ + + + + R V K++ EE
Sbjct: 1890 EAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 92.0 bits (227), Expect = 2e-18
Identities = 97/417 (23%), Positives = 188/417 (45%), Gaps = 42/417 (10%)
Query: 377 IQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQL 436
+ K+E+ H+T +++ +E++ +++ +LT E + L + H++ + L
Sbjct: 961 LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA----------HQQALDDL 1010
Query: 437 SQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLR 496
E +K+ L + +VK E+ +E E+K LE+ + + E L + Q+ S+
Sbjct: 1011 QAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE---SIM 1067
Query: 497 KVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGS--- 553
+E + Q E +K+ E LN +E E+ + + K L+E + +E L+ E +
Sbjct: 1068 DLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERT 1127
Query: 554 -------LKSHLQGEKQKATEASAVEQTAESCEVQ-EMLKVARAEKDLLELSCNE--LRQ 603
L+S L E ++ +E +E+ + VQ EM K AE + E L+
Sbjct: 1128 ARAKVEKLRSDLSRELEEISER--LEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH 1185
Query: 604 ELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIK---D 660
E A KH S+ A++ + L+ + ++ S L+L + S + IK +
Sbjct: 1186 EATAAALRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAN 1244
Query: 661 MKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQL-------KTLTKQ 713
+++ LEDQ+ +HR+ + +++L S KL+ + +L RQL LT+
Sbjct: 1245 LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRG 1304
Query: 714 MKEETEEWRRFQADLQTAVVVANDIK---CEAQQELRTVKRKLLEEEEKNARLQKEL 767
T++ + L+ V N + A+ + ++ + EE E A LQ+ L
Sbjct: 1305 KLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVL 1361
Score = 85.5 bits (210), Expect = 2e-16
Identities = 134/621 (21%), Positives = 244/621 (39%), Gaps = 65/621 (10%)
Query: 157 ENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTS 216
E E + LE R+L + K I L ++ ++ E+ +AL ++
Sbjct: 1039 EQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE--- 1095
Query: 217 VSPGDTEPMIRALEEKNKNFQKELSDLEEE---NRVLKEKLIYLEH--SPNSEGAASHTG 271
D + + L++K K Q + +LEEE R + K+ L S E +
Sbjct: 1096 ----DEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE 1151
Query: 272 DSSCPTSITQESSFGSPTGNQ-MSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASD 330
++ TS+ E + Q M D++E A + V A L +
Sbjct: 1152 EAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSV--AELGEQIDN 1209
Query: 331 FEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSV-SELSLASLTEKIQKMEENHHSTAE 389
+ + + L + FK + + ++ +L + ++ H S AE
Sbjct: 1210 LQRV-----KQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAE 1264
Query: 390 ELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQE 449
E Q ++ +L+ Q+ +Q E + +DEK E Q +Q+ E L L+E
Sbjct: 1265 ETQRSVNDLTSQRAKLQTENGELSRQLDEK---EALISQLTRGKLTYTQQLEDLKRQLEE 1321
Query: 450 RVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMI 509
VK + + C + EQ E E +Q+ L+ + +V +
Sbjct: 1322 EVKAKNALAH--ALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ--------- 1370
Query: 510 KRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL---KSHLQGEKQKA- 565
R K E + + ELE +A+ L+E +E + + SL K LQ E +
Sbjct: 1371 WRTKYETDAIQRTEELEEAKKK-LAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1429
Query: 566 --TEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVE 623
E S A + + K+ K E E + EL + E + +S+ L K++
Sbjct: 1430 VDVERSNAAAAALDKKQRNFDKILAEWKQKYE----ESQSELESSQKEARSLSTELFKLK 1485
Query: 624 KDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNN 683
Y +E +H E R + LQE+ S+ ++ +TI ELE +Q A K+
Sbjct: 1486 NAY---EESLEH-LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQ 1541
Query: 684 QLISELESSV-----------IKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAV 732
+ E E+S+ ++ + K+++ER+L ++M++ R LQT++
Sbjct: 1542 SALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSL 1601
Query: 733 VVANDIKCEAQQELRTVKRKL 753
D + ++ E VK+K+
Sbjct: 1602 ----DAETRSRNEALRVKKKM 1618
Score = 72.0 bits (175), Expect = 2e-12
Identities = 122/636 (19%), Positives = 260/636 (40%), Gaps = 87/636 (13%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 221
EK AL+ ++ L + +A++ ++N L K +++ D L +++ D
Sbjct: 995 EKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQ-------VDDLEGSLEQEKKVRMD 1047
Query: 222 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQ 281
E R LE K Q+ + DLE + + L E+L + N+ A I
Sbjct: 1048 LERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNAR-----------IED 1096
Query: 282 ESSFGSPTGN---QMSSDIDEYKKNIHGNALRTSGSS----SSDVTK------------- 321
E + GS ++ + I+E ++ + A RT+ + SD+++
Sbjct: 1097 EQALGSQLQKKLKELQARIEELEEELE--AERTARAKVEKLRSDLSRELEEISERLEEAG 1154
Query: 322 --ASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQK 379
S+ + + + R L + +++ + +SV+EL + +Q+
Sbjct: 1155 GATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELG--EQIDNLQR 1212
Query: 380 MEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQE 439
+++ E + L +++ + + + A EK+ LE ++HR +AE+ +
Sbjct: 1213 VKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMC---RTLEDQMNEHRSKAEETQRS 1269
Query: 440 NEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVE 499
+ +L +R K + + + ++ ++ L +G+ L QQL R++E
Sbjct: 1270 ---VNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGK------LTYTQQLEDLKRQLE 1320
Query: 500 EENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQ 559
EE +K +N L L+ RH+ +++ + EE L+ S +
Sbjct: 1321 EE----------VKAKNA-LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1369
Query: 560 GEKQKATEASAVEQTAESCEVQEML--KVARAEK--DLLELSCNELRQELLKANGEIKHV 615
+ K E A+++T E E ++ L ++ AE+ + + C+ L + + EI+
Sbjct: 1370 QWRTKY-ETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIE-- 1426
Query: 616 SSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQH 675
L+ VE+ + + D + + + ++K ES +E++ ++ L ++ +
Sbjct: 1427 -DLMVDVERSNAAAAAL-DKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1484
Query: 676 RAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVA 735
+ + + + + L+E+ SDL QL + K + E + ++ +A+
Sbjct: 1485 KNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAE-------- 1536
Query: 736 NDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 771
K E Q L + L EE K R Q E ++
Sbjct: 1537 ---KMELQSALEEAEASLEHEEGKILRAQLEFNQIK 1569
Score = 65.5 bits (158), Expect = 2e-10
Identities = 132/641 (20%), Positives = 266/641 (41%), Gaps = 98/641 (15%)
Query: 166 LESQVRELLAEAKAKDSEINRLRSEL-------KKYKEKRTLNAEGTDALGPNVDGTSV- 217
LE R+L E KAK++ + L+S ++Y+E+ AE L +
Sbjct: 1312 LEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQW 1371
Query: 218 -SPGDTEPMIRA--LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN------SEGAAS 268
+ +T+ + R LEE K + L + EE + K LE + + +
Sbjct: 1372 RTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVD 1431
Query: 269 HTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDA 328
++ ++ ++ + +E + + + + + S S+++ K + +
Sbjct: 1432 VERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ-KEARSLSTELFKLKNAYEE 1490
Query: 329 SDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTA 388
S EH+ ET R + S GSS ++ EL + +KME S
Sbjct: 1491 S-LEHL--ETFKRENKNLQEEI-SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQ--SAL 1544
Query: 389 EELQATLQ----ELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLM 444
EE +A+L+ ++ Q ++ AE E+ + EK E EQ + + +++
Sbjct: 1545 EEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD----------EEMEQAKRNHLRVV 1594
Query: 445 NLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFE---REKLLNIQQQLTCSLRKVEEE 501
+ LQ + E T + + +++K G L + + ++ Q+ SL+ + ++
Sbjct: 1595 DSLQTSLDAE--TRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKD 1652
Query: 502 NQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGE 561
Q L+ R N+ L E + + NN++ LEE R +E Q E
Sbjct: 1653 TQIQLDDAVRA---NDDLKENIAIVERRNNLLQAELEELRAVVE-------------QTE 1696
Query: 562 KQKATEASAVEQTAESCEVQEMLKVARA-EKDLLELSCNELRQELLKANGEIKHVSSLLA 620
+ + + +T+E ++ + +K ++ ++L+ E+ +A E ++
Sbjct: 1697 RSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAK 1756
Query: 621 KVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKL 680
K D + + AE+L K Q+ ++ + K+M++TI +L+ ++++ + L
Sbjct: 1757 KAITDAAMM-------AEELK----KEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAL 1805
Query: 681 H-NNQLISELESSVIKLE-----EQKSDL---------ERQLKTLTKQMKEETEEWRRFQ 725
+ + +LE+ V +LE EQK + ER++K LT Q +E+ + R Q
Sbjct: 1806 KGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQ 1865
Query: 726 ADLQTAVVVANDIKCEAQQELRTVKRKLLE-EEEKNARLQK 765
D+ + Q +++ KR+ E EE+ N L K
Sbjct: 1866 -----------DLVDKLQLKVKAYKRQAEEAEEQANTNLSK 1895
Score = 62.0 bits (149), Expect = 2e-09
Identities = 78/367 (21%), Positives = 162/367 (44%), Gaps = 44/367 (11%)
Query: 437 SQENEKLMNLLQERVKN--EEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCS 494
S E EK M ++E E E + ELE+K +L++ + ++ Q L +
Sbjct: 842 SAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADA 901
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 554
+ ++ + +++ ++KE NE+L + E+ K +EC LK + L
Sbjct: 902 EERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDEC----SELKRDIDDL 957
Query: 555 KSHL-QGEKQK-ATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEI 612
+ L + EK+K ATE T E + E++ EK L+ + + +L ++
Sbjct: 958 ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 1017
Query: 613 KHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELED-- 670
++ K+E+ L + EQ + + L+ + + ++K +E+I +LE+
Sbjct: 1018 NTLTKAKVKLEQQVDDL----EGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1073
Query: 671 -------------------QVEQHRAVKLHNNQLISELESSVIKLEEQ-------KSDLE 704
++E +A+ + + EL++ + +LEE+ ++ +E
Sbjct: 1074 QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVE 1133
Query: 705 RQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEA--QQELRTVKRKLLEEEEKNAR 762
+ L+++++E +E R +A T+V + + K EA Q+ R ++ L+ E A
Sbjct: 1134 KLRSDLSRELEEISE--RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAA 1191
Query: 763 LQKELGD 769
L+K+ D
Sbjct: 1192 LRKKHAD 1198
Score = 60.1 bits (144), Expect = 8e-09
Identities = 71/288 (24%), Positives = 122/288 (42%), Gaps = 46/288 (15%)
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 554
L+ E E + A +KEE +L E LE + K LEE V+L E L
Sbjct: 840 LKSAEREKEMA-----SMKEEFTRLKEALE----KSEARRKELEEKMVSL---LQEKNDL 887
Query: 555 KSHLQGEKQKATEA---------------SAVEQTAESCEVQEMLKVA-RAEKDLLELSC 598
+ +Q E+ +A + V++ E E +E + A+K LE C
Sbjct: 888 QLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDEC 947
Query: 599 NELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEI 658
+EL+++ I + LAKVEK+ K +++ + L+ L E ++ E
Sbjct: 948 SELKRD-------IDDLELTLAKVEKE----KHATENKVKNLTEEMAGLDEIIAKLTKEK 996
Query: 659 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 718
K ++E + D ++ ++ L + +KLE+Q DLE L+ K +
Sbjct: 997 KALQEAHQQALDDLQAEE-------DKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLE 1049
Query: 719 EEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKE 766
R+ + DL+ D++ + QQ +K+K E NAR++ E
Sbjct: 1050 RAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDE 1097
Score = 57.8 bits (138), Expect = 4e-08
Identities = 116/615 (18%), Positives = 234/615 (38%), Gaps = 63/615 (10%)
Query: 129 RKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEA-KAKDSEINRL 187
++ +S S TK+ + ++ E +K A Q E EA AK S + +
Sbjct: 1358 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKT 1417
Query: 188 RSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEEN 247
+ L+ E ++ E ++A +D + + ++ ++K + Q EL ++E
Sbjct: 1418 KHRLQNEIEDLMVDVERSNAAAAALDKKQ---RNFDKILAEWKQKYEESQSELESSQKEA 1474
Query: 248 RVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGN 307
R L +L L+++ E + H QE SD+ E
Sbjct: 1475 RSLSTELFKLKNA--YEESLEHLETFKRENKNLQEEI----------SDLTEQ------- 1515
Query: 308 ALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSE 367
L +SG + ++ K +A E + + S K + + + E
Sbjct: 1516 -LGSSGKTIHELEKVRKQLEAEKME-LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE 1573
Query: 368 LSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFH 427
LA E++++ + NH + LQ +L + + E +K+ + +E
Sbjct: 1574 RKLAEKDEEMEQAKRNHLRVVDSLQTSLDA---ETRSRNEALRVKKKMEGDLNEMEIQLS 1630
Query: 428 QHRERAEQLSQENEKLMNLLQE-RVKNEEPTTQEGKI---IELEQKCTGILEQGRFEREK 483
A + ++ + L +LL++ +++ ++ + I + ++ +L+ E E+
Sbjct: 1631 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA---ELEE 1687
Query: 484 LLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKL------------------NEFLEL 525
L + +Q S + E+E E ++ L +N L E ++
Sbjct: 1688 LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1747
Query: 526 ERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLK 585
R+ K + + + E LK E + +HL E+ K ++ + E +
Sbjct: 1748 CRNAEEKAKKAITDAAMMAEELKKEQDT-SAHL--ERMKKNMEQTIKDLQHRLDEAEQIA 1804
Query: 586 VARAEKDL--LELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRT 643
+ +K L LE EL EL E K + + + K +KE+ +Q E+ +
Sbjct: 1805 LKGGKKQLQKLEARVRELENEL---EAEQKRNAESVKGMRKSERRIKELT-YQTEEDRKN 1860
Query: 644 SLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDL 703
L+LQ+ + ++K K E E+Q + + + E E E Q + L
Sbjct: 1861 LLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1920
Query: 704 ERQLKTL-TKQMKEE 717
+ + + TK + EE
Sbjct: 1921 RAKSRDIGTKGLNEE 1935
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 91.3 bits (225), Expect = 3e-18
Identities = 187/829 (22%), Positives = 333/829 (40%), Gaps = 108/829 (13%)
Query: 33 KSSKSSTSLAFESRLSRLKRASSEDTLNKPGSTAASGVVRLKKTATAGAISELTESRLRS 92
K+ K L E L LK EDTL+ STA +R K+ + + + RS
Sbjct: 1143 KAEKQKRDLGEE--LEALK-TELEDTLD---STATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 93 GTGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPST 152
++ A E + + + + R +N K+ + N + LR
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFK---RAKANLDKNKQTLEKENADLAGE-LRVLG- 1251
Query: 153 KPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNV 212
+ KQE E +K LE+QV+EL ++K D E R R+EL K E +
Sbjct: 1252 QAKQEVEH-KKKKLEAQVQEL--QSKCSDGE--RARAELNDKVHKLQNEVESVTGMLNEA 1306
Query: 213 DGTSVSPG-----------DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIY-LEHS 260
+G ++ DT+ +++ + N +L LEEE L+++L +E
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Query: 261 PNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSS--- 317
N E S T + S + F S T + ++K I + +++
Sbjct: 1367 QNLERHIS-TLNIQLSDSKKKLQDFAS-TVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1424
Query: 318 -DVTKASLSPDASDFEHITAETPSRPLSST----SNPFKSSKCSTAGSSPNSVSELSLAS 372
+ TK L + D + R L S F S E A
Sbjct: 1425 LEKTKNRLQQELDDL--VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 373 LTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRER 432
+ ++ E S A L+ L+ + ++ + L AE E LV K + + H+ +
Sbjct: 1483 A--EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 433 AEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFER----------E 482
L + E++ L+E +++E T++ K+ LE + +G+FER E
Sbjct: 1541 KRALETQMEEMKTQLEE-LEDELQATEDAKL-RLEVNMQAL--KGQFERDLQARDEQNEE 1596
Query: 483 KLLNIQQQLTCSLRKVEEEN-QGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECR 541
K +Q+QL ++E+E Q AL + K E + + LEL+ + K EE
Sbjct: 1597 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD--LELQADS---AIKGREEAI 1651
Query: 542 VTLEGLKMENGSLKSHLQGEKQ---------KATEASAVEQTAESCEVQEMLKVARAEKD 592
L L+ + + L+ + K E A A+ ++QE L A +
Sbjct: 1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711
Query: 593 LLELSCNELRQEL---LKANGEIK--------HVSSLLAKVEKDYSYLKEICDH------ 635
+L EL +EL L ++ ++ L ++E++ ++ + D
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 636 QAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQV-EQHRAVKLHNNQLISELESSVI 694
QAEQLS + A ++++ + ++ EL ++ E AVK I+ LE+ +
Sbjct: 1772 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1831
Query: 695 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQ---ELRTVKR 751
+LEEQ R+ + TK +K++ ++ + ++ +A K +A++ ++ +KR
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1891
Query: 752 KLLEEEEKNAR-------LQKELGDV----QGHGRVVTS-----RAAPP 784
+L E EE++ R LQ+EL + + GR V + R PP
Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1940
Score = 85.1 bits (209), Expect = 2e-16
Identities = 102/466 (21%), Positives = 201/466 (43%), Gaps = 84/466 (18%)
Query: 366 SELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETS 425
+E L L +K ++ E + E+LQA + ++ ++M L A+ ++L + +E
Sbjct: 878 AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR 937
Query: 426 FHQHRERAEQLSQENEKL---MNLLQERVKNE---------EPTTQEGKIIELEQKCTGI 473
+ +R +QL E +K+ M L+E+++ E E T E KI +LE + +
Sbjct: 938 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 997
Query: 474 LEQ-GRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNM 532
+Q + +E+ L ++++++ + EE + A + K LK ++E + LE+
Sbjct: 998 DDQNNKLSKERKL-LEERISDLTTNLAEEEEKAKNLTK-LKNKHESMISELEVRLKKEEK 1055
Query: 533 MAKTLEECRVTLEG------------------LKMENGSLKSHLQGEKQKATEASAVEQT 574
+ LE+ + LEG LKM+ + LQ + + A +
Sbjct: 1056 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1115
Query: 575 A---------ESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV-------SSL 618
A ++QE L RA ++ E +L +EL E++ L
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1175
Query: 619 LAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMK----ETIFELEDQVEQ 674
AK E++ + LK+ D E+ +A++++M+ + + EL +Q+EQ
Sbjct: 1176 RAKREQEVTVLKKALD--------------EETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 675 HRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQ----- 729
+ K + L+ + LE++ +DL +L+ L + +E + ++ +A +Q
Sbjct: 1222 FKRAK-------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274
Query: 730 -----TAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDV 770
A ND + Q E+ +V L E E K +L K++ +
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Score = 82.0 bits (201), Expect = 2e-15
Identities = 91/393 (23%), Positives = 180/393 (45%), Gaps = 49/393 (12%)
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 435
++ + EE + +ELQ T + + ++EL ++ +L +EK +L+ EQ
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ----------EQ 902
Query: 436 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 495
L E E + RV ++ +Q+ IL + E+ + QQL
Sbjct: 903 LQAETELYAEAEEMRV----------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 952
Query: 496 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 555
+K+ ++ L++ ++L+EE E + L+LE+ K LE+ E L M++ +
Sbjct: 953 KKMAQQ---MLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLED-----EILVMDD---Q 1000
Query: 556 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV 615
++ +++K E + T E +E K K+ E +EL L K + +
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1060
Query: 616 SSLLAKVEKDYS-YLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQ 674
L K+E D S + ++I D QA Q++ ++L +K E A + + + I + + +++
Sbjct: 1061 EKLKRKLEGDASDFHEQIADLQA-QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 675 HRAVKLHNNQLISELESSVI---KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 731
R ++ H + L +L+S K E+QK DL +L+ L +++ D +
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-----------DTLDS 1168
Query: 732 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQ 764
+++ + +QE+ TV +K L+EE ++ Q
Sbjct: 1169 TATQQELRAKREQEV-TVLKKALDEETRSHEAQ 1200
Score = 78.6 bits (192), Expect = 2e-14
Identities = 141/664 (21%), Positives = 259/664 (39%), Gaps = 99/664 (14%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEK---RTLNAEGTDALGPNVDGTSVS 218
EK E+++++L E D + N+L E K +E+ T N + N+
Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK-- 1036
Query: 219 PGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAAS--HTGDSSCP 276
E MI LE + K +K +LE+ LK KL EG AS H +
Sbjct: 1037 -NKHESMISELEVRLKKEEKSRQELEK----LKRKL---------EGDASDFHEQIADLQ 1082
Query: 277 TSITQESSFGSPTGNQMSSDIDEYKKNI--HGNALRTSGSSSSDVTKASLSPDASDFEHI 334
I + + ++ + + I NAL+ ++ D+
Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1142
Query: 335 TAETPSRPLSSTSNPFKSSKCSTAGSSPNS----------VSELSLA------SLTEKIQ 378
AE R L K+ T S+ V+ L A S ++Q
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 379 KMEENHHSTAEELQATLQEL----SDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 434
+M + H EEL L++ ++ + Q L EN L E +L Q ++ E
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG----QAKQEVE 1258
Query: 435 QLSQENEKLMNLLQERVKNEEPTTQE--GKIIELE---QKCTGILEQGRFEREKLLNIQQ 489
++ E + LQ + + E E K+ +L+ + TG+L + + KL
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1318
Query: 490 QLTCSLRKVEEENQGALEMIKRLKEENEKLN---EFLELERHNNNMMAKTLEECRVTLEG 546
L+ L+ +E Q +E +KLN + +LE N++ + EE +
Sbjct: 1319 SLSSQLQDTQELLQ---------EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK-QN 1368
Query: 547 LKMENGSLKSHLQGEKQKATE-ASAVEQTAESCE--------VQEMLKVARAEKDLLELS 597
L+ +L L K+K + AS VE E + + + + A D LE +
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1428
Query: 598 CNELRQELLKANGEIKHVSSLLAKVEKDYSYL-------KEICDHQAEQLSRTSLKLQEK 650
N L+QEL ++ + L++ +EK K I A++ R + +EK
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 651 ASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLIS---ELESSVIKLEEQKSDLERQL 707
+++ + + ++E + E+ ++ +K L+S ++ +V +LE+ K LE Q+
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548
Query: 708 KTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVK----RKLLEEEEKNARL 763
+ + Q++E L+ + D K + ++ +K R L +E+N
Sbjct: 1549 EEMKTQLEE-----------LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 764 QKEL 767
+++L
Sbjct: 1598 RRQL 1601
Score = 65.1 bits (157), Expect = 2e-10
Identities = 62/282 (21%), Positives = 125/282 (44%), Gaps = 26/282 (9%)
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNE---FLELERHNNNMMAKTLEECRVTLEGLKMEN 551
L+K +E Q A +K L++++ +L E L+ + + EE RV L K E
Sbjct: 868 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 927
Query: 552 GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 611
+ ++ ++ + Q Q+ML + E+ L E + +L K E
Sbjct: 928 EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL---EEQLEEEEAARQKLQLEKVTAE 984
Query: 612 IKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQ 671
K + K+E + + D Q +LS+ L+E+ I D+ + E E++
Sbjct: 985 AK-----IKKLEDEIL----VMDDQNNKLSKERKLLEER-------ISDLTTNLAEEEEK 1028
Query: 672 VEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 731
+ +K + +ISELE + K E+ + +LE+ L ++++ + ++ ADLQ
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEK----LKRKLEGDASDFHEQIADLQAQ 1084
Query: 732 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGH 773
+ + ++EL+ +L +E + K++ +++GH
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1126
Score = 55.8 bits (133), Expect = 1e-07
Identities = 86/441 (19%), Positives = 189/441 (42%), Gaps = 41/441 (9%)
Query: 153 KPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNV 212
K + E+ K + V EL +A ++++ ++++L++ +++ + L N+
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1576
Query: 213 DGTSVSPGDTEPMIRALEEKNKNFQKEL--------SDLEEENRVLKEKLIYLEHSPNSE 264
G E ++A +E+N+ +++L ++LE+E K++ + E
Sbjct: 1577 QALK---GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER---KQRALAAAAKKKLE 1630
Query: 265 GAASHTGDSSCPTSITQESSFGSPTGNQMS-SDIDEYKKNIHGNALRTSGSSSSDVTKA- 322
G + +E + Q D ++ + ++ + KA
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690
Query: 323 SLSPDASDF-EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME 381
SL D E + A +R + + + +++ S N++ + L +I ++E
Sbjct: 1691 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD-EKRRLEARIAQLE 1749
Query: 382 ENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENE 441
E EE Q ++ +SD+ V++ T + E+L +E ++ ++ +QL ++N+
Sbjct: 1750 EE----LEEEQGNMEAMSDR---VRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1802
Query: 442 KLMNLLQER---VKNEEPTT---QEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 495
+L + L E VK++ +T E KI +LE++ + + + L ++L L
Sbjct: 1803 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862
Query: 496 RKVEEENQGALEM----------IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLE 545
+VE+E + A + +K+LK + E+ E + N + + L+E + E
Sbjct: 1863 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Query: 546 GLKMENGSLKSHLQGEKQKAT 566
+ E +LKS L+G + T
Sbjct: 1923 AMGREVNALKSKLRGPPPQET 1943
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 91.3 bits (225), Expect = 3e-18
Identities = 187/829 (22%), Positives = 333/829 (40%), Gaps = 108/829 (13%)
Query: 33 KSSKSSTSLAFESRLSRLKRASSEDTLNKPGSTAASGVVRLKKTATAGAISELTESRLRS 92
K+ K L E L LK EDTL+ STA +R K+ + + + RS
Sbjct: 1136 KAEKQKRDLGEE--LEALK-TELEDTLD---STATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 93 GTGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPST 152
++ A E + + + + R +N K+ + N + LR
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFK---RAKANLDKNKQTLEKENADLAGE-LRVLG- 1244
Query: 153 KPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNV 212
+ KQE E +K LE+QV+EL ++K D E R R+EL K E +
Sbjct: 1245 QAKQEVEH-KKKKLEAQVQEL--QSKCSDGE--RARAELNDKVHKLQNEVESVTGMLNEA 1299
Query: 213 DGTSVSPG-----------DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIY-LEHS 260
+G ++ DT+ +++ + N +L LEEE L+++L +E
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Query: 261 PNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSS--- 317
N E S T + S + F S T + ++K I + +++
Sbjct: 1360 QNLERHIS-TLNIQLSDSKKKLQDFAS-TVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1417
Query: 318 -DVTKASLSPDASDFEHITAETPSRPLSST----SNPFKSSKCSTAGSSPNSVSELSLAS 372
+ TK L + D + R L S F S E A
Sbjct: 1418 LEKTKNRLQQELDDL--VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 373 LTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRER 432
+ ++ E S A L+ L+ + ++ + L AE E LV K + + H+ +
Sbjct: 1476 A--EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 433 AEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFER----------E 482
L + E++ L+E +++E T++ K+ LE + +G+FER E
Sbjct: 1534 KRALETQMEEMKTQLEE-LEDELQATEDAKL-RLEVNMQAL--KGQFERDLQARDEQNEE 1589
Query: 483 KLLNIQQQLTCSLRKVEEEN-QGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECR 541
K +Q+QL ++E+E Q AL + K E + + LEL+ + K EE
Sbjct: 1590 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD--LELQADS---AIKGREEAI 1644
Query: 542 VTLEGLKMENGSLKSHLQGEKQ---------KATEASAVEQTAESCEVQEMLKVARAEKD 592
L L+ + + L+ + K E A A+ ++QE L A +
Sbjct: 1645 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704
Query: 593 LLELSCNELRQEL---LKANGEIK--------HVSSLLAKVEKDYSYLKEICDH------ 635
+L EL +EL L ++ ++ L ++E++ ++ + D
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1764
Query: 636 QAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQV-EQHRAVKLHNNQLISELESSVI 694
QAEQLS + A ++++ + ++ EL ++ E AVK I+ LE+ +
Sbjct: 1765 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1824
Query: 695 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQ---ELRTVKR 751
+LEEQ R+ + TK +K++ ++ + ++ +A K +A++ ++ +KR
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1884
Query: 752 KLLEEEEKNAR-------LQKELGDV----QGHGRVVTS-----RAAPP 784
+L E EE++ R LQ+EL + + GR V + R PP
Sbjct: 1885 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1933
Score = 85.1 bits (209), Expect = 2e-16
Identities = 102/466 (21%), Positives = 201/466 (43%), Gaps = 84/466 (18%)
Query: 366 SELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETS 425
+E L L +K ++ E + E+LQA + ++ ++M L A+ ++L + +E
Sbjct: 871 AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR 930
Query: 426 FHQHRERAEQLSQENEKL---MNLLQERVKNE---------EPTTQEGKIIELEQKCTGI 473
+ +R +QL E +K+ M L+E+++ E E T E KI +LE + +
Sbjct: 931 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 990
Query: 474 LEQ-GRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNM 532
+Q + +E+ L ++++++ + EE + A + K LK ++E + LE+
Sbjct: 991 DDQNNKLSKERKL-LEERISDLTTNLAEEEEKAKNLTK-LKNKHESMISELEVRLKKEEK 1048
Query: 533 MAKTLEECRVTLEG------------------LKMENGSLKSHLQGEKQKATEASAVEQT 574
+ LE+ + LEG LKM+ + LQ + + A +
Sbjct: 1049 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1108
Query: 575 A---------ESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV-------SSL 618
A ++QE L RA ++ E +L +EL E++ L
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168
Query: 619 LAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMK----ETIFELEDQVEQ 674
AK E++ + LK+ D E+ +A++++M+ + + EL +Q+EQ
Sbjct: 1169 RAKREQEVTVLKKALD--------------EETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 675 HRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQ----- 729
+ K + L+ + LE++ +DL +L+ L + +E + ++ +A +Q
Sbjct: 1215 FKRAK-------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267
Query: 730 -----TAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDV 770
A ND + Q E+ +V L E E K +L K++ +
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Score = 82.0 bits (201), Expect = 2e-15
Identities = 91/393 (23%), Positives = 180/393 (45%), Gaps = 49/393 (12%)
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 435
++ + EE + +ELQ T + + ++EL ++ +L +EK +L+ EQ
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ----------EQ 895
Query: 436 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 495
L E E + RV ++ +Q+ IL + E+ + QQL
Sbjct: 896 LQAETELYAEAEEMRV----------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 945
Query: 496 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 555
+K+ ++ L++ ++L+EE E + L+LE+ K LE+ E L M++ +
Sbjct: 946 KKMAQQ---MLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLED-----EILVMDD---Q 993
Query: 556 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV 615
++ +++K E + T E +E K K+ E +EL L K + +
Sbjct: 994 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1053
Query: 616 SSLLAKVEKDYS-YLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQ 674
L K+E D S + ++I D QA Q++ ++L +K E A + + + I + + +++
Sbjct: 1054 EKLKRKLEGDASDFHEQIADLQA-QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 675 HRAVKLHNNQLISELESSVI---KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 731
R ++ H + L +L+S K E+QK DL +L+ L +++ D +
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-----------DTLDS 1161
Query: 732 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQ 764
+++ + +QE+ TV +K L+EE ++ Q
Sbjct: 1162 TATQQELRAKREQEV-TVLKKALDEETRSHEAQ 1193
Score = 78.6 bits (192), Expect = 2e-14
Identities = 141/664 (21%), Positives = 259/664 (39%), Gaps = 99/664 (14%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEK---RTLNAEGTDALGPNVDGTSVS 218
EK E+++++L E D + N+L E K +E+ T N + N+
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK-- 1029
Query: 219 PGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAAS--HTGDSSCP 276
E MI LE + K +K +LE+ LK KL EG AS H +
Sbjct: 1030 -NKHESMISELEVRLKKEEKSRQELEK----LKRKL---------EGDASDFHEQIADLQ 1075
Query: 277 TSITQESSFGSPTGNQMSSDIDEYKKNI--HGNALRTSGSSSSDVTKASLSPDASDFEHI 334
I + + ++ + + I NAL+ ++ D+
Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1135
Query: 335 TAETPSRPLSSTSNPFKSSKCSTAGSSPNS----------VSELSLA------SLTEKIQ 378
AE R L K+ T S+ V+ L A S ++Q
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 379 KMEENHHSTAEELQATLQEL----SDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 434
+M + H EEL L++ ++ + Q L EN L E +L Q ++ E
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG----QAKQEVE 1251
Query: 435 QLSQENEKLMNLLQERVKNEEPTTQE--GKIIELE---QKCTGILEQGRFEREKLLNIQQ 489
++ E + LQ + + E E K+ +L+ + TG+L + + KL
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1311
Query: 490 QLTCSLRKVEEENQGALEMIKRLKEENEKLN---EFLELERHNNNMMAKTLEECRVTLEG 546
L+ L+ +E Q +E +KLN + +LE N++ + EE +
Sbjct: 1312 SLSSQLQDTQELLQ---------EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK-QN 1361
Query: 547 LKMENGSLKSHLQGEKQKATE-ASAVEQTAESCE--------VQEMLKVARAEKDLLELS 597
L+ +L L K+K + AS VE E + + + + A D LE +
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1421
Query: 598 CNELRQELLKANGEIKHVSSLLAKVEKDYSYL-------KEICDHQAEQLSRTSLKLQEK 650
N L+QEL ++ + L++ +EK K I A++ R + +EK
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 651 ASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLIS---ELESSVIKLEEQKSDLERQL 707
+++ + + ++E + E+ ++ +K L+S ++ +V +LE+ K LE Q+
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541
Query: 708 KTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVK----RKLLEEEEKNARL 763
+ + Q++E L+ + D K + ++ +K R L +E+N
Sbjct: 1542 EEMKTQLEE-----------LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 764 QKEL 767
+++L
Sbjct: 1591 RRQL 1594
Score = 65.1 bits (157), Expect = 2e-10
Identities = 62/282 (21%), Positives = 125/282 (44%), Gaps = 26/282 (9%)
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNE---FLELERHNNNMMAKTLEECRVTLEGLKMEN 551
L+K +E Q A +K L++++ +L E L+ + + EE RV L K E
Sbjct: 861 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 920
Query: 552 GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 611
+ ++ ++ + Q Q+ML + E+ L E + +L K E
Sbjct: 921 EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL---EEQLEEEEAARQKLQLEKVTAE 977
Query: 612 IKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQ 671
K + K+E + + D Q +LS+ L+E+ I D+ + E E++
Sbjct: 978 AK-----IKKLEDEIL----VMDDQNNKLSKERKLLEER-------ISDLTTNLAEEEEK 1021
Query: 672 VEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 731
+ +K + +ISELE + K E+ + +LE+ L ++++ + ++ ADLQ
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEK----LKRKLEGDASDFHEQIADLQAQ 1077
Query: 732 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGH 773
+ + ++EL+ +L +E + K++ +++GH
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1119
Score = 55.8 bits (133), Expect = 1e-07
Identities = 86/441 (19%), Positives = 189/441 (42%), Gaps = 41/441 (9%)
Query: 153 KPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNV 212
K + E+ K + V EL +A ++++ ++++L++ +++ + L N+
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1569
Query: 213 DGTSVSPGDTEPMIRALEEKNKNFQKEL--------SDLEEENRVLKEKLIYLEHSPNSE 264
G E ++A +E+N+ +++L ++LE+E K++ + E
Sbjct: 1570 QALK---GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER---KQRALAAAAKKKLE 1623
Query: 265 GAASHTGDSSCPTSITQESSFGSPTGNQMS-SDIDEYKKNIHGNALRTSGSSSSDVTKA- 322
G + +E + Q D ++ + ++ + KA
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683
Query: 323 SLSPDASDF-EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME 381
SL D E + A +R + + + +++ S N++ + L +I ++E
Sbjct: 1684 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD-EKRRLEARIAQLE 1742
Query: 382 ENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENE 441
E EE Q ++ +SD+ V++ T + E+L +E ++ ++ +QL ++N+
Sbjct: 1743 EE----LEEEQGNMEAMSDR---VRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1795
Query: 442 KLMNLLQER---VKNEEPTT---QEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 495
+L + L E VK++ +T E KI +LE++ + + + L ++L L
Sbjct: 1796 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855
Query: 496 RKVEEENQGALEM----------IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLE 545
+VE+E + A + +K+LK + E+ E + N + + L+E + E
Sbjct: 1856 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Query: 546 GLKMENGSLKSHLQGEKQKAT 566
+ E +LKS L+G + T
Sbjct: 1916 AMGREVNALKSKLRGPPPQET 1936
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 90.9 bits (224), Expect = 4e-18
Identities = 139/614 (22%), Positives = 238/614 (38%), Gaps = 97/614 (15%)
Query: 221 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN-------SEGAASHTGDS 273
+TE + ++E+ + + EL+ E + + L+EKL+ L N +E +
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE 904
Query: 274 SCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEH 333
C I + + DE + NA T+ + + L D D E
Sbjct: 905 RCDQLIKAKFQLEAKIKEVTERAEDEEEI----NAELTAKKRKLEDECSELKKDIDDLEL 960
Query: 334 ITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQA 393
A+ + K +T N ELS L E I K+ + E Q
Sbjct: 961 TLAKV------------EKEKHATENKVKNLTEELS--GLDETIAKLTREKKALQEAHQQ 1006
Query: 394 TLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKN 453
L +L ++ V L KL + LE+S Q ++ L + KL
Sbjct: 1007 ALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKL---------- 1056
Query: 454 EEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLR-KVEEENQGALEMIKRL 512
EG ++L Q+ LE + + ++ L + C L+ KVE+E L+ K++
Sbjct: 1057 ------EGD-LKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKI 1109
Query: 513 KE---ENEKLNEFLELER-------HNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEK 562
KE E+L E +E ER + A+ LEE E L+ G + ++ K
Sbjct: 1110 KELQARIEELEEEIEAERATRAKTEKQRSDYARELEELS---ERLEEAGGVTSTQIELNK 1166
Query: 563 QKATEASAVEQTAESCEVQEMLKVARAEK-------------DLLELSCNELRQELLKAN 609
++ E + + E +Q VA K D L+ +L +E +
Sbjct: 1167 KREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1226
Query: 610 GEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLK---LQEKASESDAEIKDMKETIF 666
EI +SS + V K + L++IC +QLS K +Q SE + ++
Sbjct: 1227 LEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAG 1286
Query: 667 ELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ------------- 713
EL Q+E+ ++ +S+L S +Q +L+RQL+ K
Sbjct: 1287 ELSRQLEEKESI-------VSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRH 1339
Query: 714 ----MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEE-EEKNARLQKELG 768
++E+ EE + +A+LQ A+ AN + + + T + EE EE +L + L
Sbjct: 1340 DCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1399
Query: 769 DVQGHGRVVTSRAA 782
D + V ++ A
Sbjct: 1400 DSEEQVEAVNAKCA 1413
Score = 76.3 bits (186), Expect = 1e-13
Identities = 130/649 (20%), Positives = 254/649 (39%), Gaps = 86/649 (13%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 221
EK A E++V+ L E D I +L E K +E + A V+ + +
Sbjct: 968 EKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSK 1027
Query: 222 TEPMIRALEEKNKNFQKELSDLEEENRVLK-------EKLIYLEHSPNSEGAASHTGD-- 272
E + LE + +K DLE R L+ E ++ LE+ D
Sbjct: 1028 LEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFE 1087
Query: 273 -SSCPTSITQESSFG---SPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDA 328
+ + E + G ++ + I+E ++ I T+A
Sbjct: 1088 YCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAER----------ATRAKTEKQR 1137
Query: 329 SDFEHITAETPSR-----PLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEEN 383
SD+ E R ++ST + + + E +L + + +
Sbjct: 1138 SDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQH-EAMVAALRKK 1196
Query: 384 HHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL 443
H + EL + L +Q +++ +E + +D+ + S + + E++ + E
Sbjct: 1197 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLED- 1255
Query: 444 MNLLQERVKNEEP-------TTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLR 496
L + R KNEE TTQ+ ++ Q G L + E+E +++ QL+ S +
Sbjct: 1256 -QLSEARGKNEEIQRSLSELTTQKSRL----QTEAGELSRQLEEKESIVS---QLSRSKQ 1307
Query: 497 KVEEENQGALEMIKRLKEENEKLNEF---LELERHNNNMMAKTLEECRVTLEGLKMENGS 553
++ + E+ ++L+EEN+ N L+ RH+ +++ + EE + L+
Sbjct: 1308 AFTQQTE---ELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1364
Query: 554 LKSHLQGEKQKATEASAVEQTAESCEVQ----EMLKVARAEKDLLELSCNELRQELLKAN 609
S + + K E A+++T E E + + L+ + + + + C L + +
Sbjct: 1365 ANSEVAQWRTKY-ETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQ 1423
Query: 610 GEIKHVSSLLAKVEKDYSYLKEICDHQA---EQLSRTSLKLQEKASESDAEIKDMKETIF 666
GE++ L+ VE+ S + Q + L+ K +E +E +A +K+ +
Sbjct: 1424 GEVE---DLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLST 1480
Query: 667 EL-------EDQVEQHRAVKLHNNQL-----------------ISELESSVIKLEEQKSD 702
EL E+ ++Q VK N L I ELE S ++E +K+D
Sbjct: 1481 ELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKAD 1540
Query: 703 LERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKR 751
++ L+ ++ E + R Q +L + E +E+ +KR
Sbjct: 1541 IQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKR 1589
Score = 66.6 bits (161), Expect = 8e-11
Identities = 161/731 (22%), Positives = 280/731 (38%), Gaps = 155/731 (21%)
Query: 157 ENEGGEKAALESQVREL---LAEAKAKDSEINRLRSELKKYKEKRTLNA--------EGT 205
E+ KA LE R L L+EA+ K+ EI R SEL K + A E
Sbjct: 1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKE 1296
Query: 206 DALGPNVDGTSVSPGDTEPMIRALEEKNKN-------FQKELSDLE------EENRVLKE 252
+ TE + R LEE+NK Q D + EE + K
Sbjct: 1297 SIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKA 1356
Query: 253 KLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTS 312
+L NSE A T + T+E Q D +E + ++
Sbjct: 1357 ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKC---- 1412
Query: 313 GSSSSDVTKASLSPDASDF--EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSL 370
+S + TK L + D + A + + L F S +EL
Sbjct: 1413 --ASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEA 1470
Query: 371 A-----SLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELT---AENEKLVDEKTIL 422
+ SL+ ++ K++ + ++L+ +E + +Q + +LT AEN K +
Sbjct: 1471 SLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTI------ 1524
Query: 423 ETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQ-GRFER 481
H+ + +Q+ E + L+E E +E KI+ ++ + T + + R
Sbjct: 1525 ----HELEKSRKQIELEKADIQLALEEAEAALEH--EEAKILRIQLELTQVKSEIDRKIA 1578
Query: 482 EKLLNIQQQLTCSLRKVEEENQGAL--------EMIKRLKEENEKLNEFLELERHNNNMM 533
EK I+Q L + ++ E Q AL E I+ K+ LNE H N
Sbjct: 1579 EKDEEIEQ-LKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQA 1637
Query: 534 AKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAE--SCEVQEMLKVARAEK 591
A+TL+ R LK L L+G++ + + VE+ A EV+E+ RA
Sbjct: 1638 AETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEEL----RATL 1693
Query: 592 DLLELSCNELRQELLKANGEIKHV----SSLL---AKVEKDYSYLKEICDHQAEQLSRTS 644
+ E + QELL +N ++ + +SL+ K+E D L+ + E SR +
Sbjct: 1694 EQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQS----EVEDASRDA 1749
Query: 645 LKLQEKASES--DAEI-------------------KDMKETIFELEDQVEQHRAVKLHNN 683
+EKA ++ DA + K++++T+ +L+ ++++ + L
Sbjct: 1750 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG 1809
Query: 684 QL-ISELESSVIKLE-----EQKSDLE---------RQLKTLTKQMKEETE--------- 719
+ I +LE+ + +LE EQK + E R++K LT Q +E+ +
Sbjct: 1810 KKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLV 1869
Query: 720 --------------------------EWRRFQADLQTA-----VVVANDIKCEAQQELRT 748
++R+ Q +L+ A + + K A+ T
Sbjct: 1870 DKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFT 1929
Query: 749 VKRKLLEEEEK 759
R ++ E E+
Sbjct: 1930 SSRMVVHESEE 1940
Score = 54.3 bits (129), Expect = 4e-07
Identities = 67/288 (23%), Positives = 121/288 (42%), Gaps = 46/288 (15%)
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 554
L+ E E + A +KEE +K + E + K LEE VTL E L
Sbjct: 841 LKSAETEKEMAT-----MKEEFQKTKD----ELAKSEAKRKELEEKLVTLV---QEKNDL 888
Query: 555 KSHLQGEKQKATEA---------------SAVEQTAESCEVQEMLKVA-RAEKDLLELSC 598
+ +Q E + +A + +++ E E +E + A+K LE C
Sbjct: 889 QLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 948
Query: 599 NELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEI 658
+EL+++ I + LAKVEK+ K +++ + L+ L E ++ E
Sbjct: 949 SELKKD-------IDDLELTLAKVEKE----KHATENKVKNLTEELSGLDETIAKLTREK 997
Query: 659 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 718
K ++E + D ++ ++ L + KLE+Q DLE L+ K +
Sbjct: 998 KALQEAHQQALDDLQAEE-------DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLE 1050
Query: 719 EEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKE 766
R+ + DL+ A D++ + QQ +K+K E + ++++ E
Sbjct: 1051 RNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDE 1098
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 90.9 bits (224), Expect = 4e-18
Identities = 181/805 (22%), Positives = 325/805 (40%), Gaps = 99/805 (12%)
Query: 33 KSSKSSTSLAFESRLSRLKRASSEDTLNKPGSTAASGVVRLKKTATAGAISELTESRLRS 92
K+ K L E L LK EDTL+ STA +R K+ + + + RS
Sbjct: 1136 KAEKQKRDLGEE--LEALK-TELEDTLD---STATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 93 GTGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPST 152
++ A E + + + + R +N K+ + N + LR
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFK---RAKANLDKNKQTLEKENADLAGE-LRVLG- 1244
Query: 153 KPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNV 212
+ KQE E +K LE+QV+EL ++K D E R R+EL K E +
Sbjct: 1245 QAKQEVEH-KKKKLEAQVQEL--QSKCSDGE--RARAELNDKVHKLQNEVESVTGMLNEA 1299
Query: 213 DGTSVSPG-----------DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIY-LEHS 260
+G ++ DT+ +++ + N +L LEEE L+++L +E
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Query: 261 PNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSS--- 317
N E S T + S + F S T + ++K I + +++
Sbjct: 1360 QNLERHIS-TLNIQLSDSKKKLQDFAS-TVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1417
Query: 318 -DVTKASLSPDASDFEHITAETPSRPLSST----SNPFKSSKCSTAGSSPNSVSELSLAS 372
+ TK L + D + R L S F S E A
Sbjct: 1418 LEKTKNRLQQELDDL--VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 373 LTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRER 432
+ ++ E S A L+ L+ + ++ + L AE E LV K + + H+ +
Sbjct: 1476 A--EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 433 AEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFER----------E 482
L + E++ L+E +++E T++ K+ LE + +G+FER E
Sbjct: 1534 KRALETQMEEMKTQLEE-LEDELQATEDAKL-RLEVNMQAL--KGQFERDLQARDEQNEE 1589
Query: 483 KLLNIQQQLTCSLRKVEEEN-QGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECR 541
K +Q+QL ++E+E Q AL + K E + + LEL+ + K EE
Sbjct: 1590 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD--LELQADS---AIKGREEAI 1644
Query: 542 VTLEGLKMENGSLKSHLQGEKQ---------KATEASAVEQTAESCEVQEMLKVARAEKD 592
L L+ + + L+ + K E A A+ ++QE L A +
Sbjct: 1645 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704
Query: 593 LLELSCNELRQEL---LKANGEIK--------HVSSLLAKVEKDYSYLKEICDH------ 635
+L EL +EL L ++ ++ L ++E++ ++ + D
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1764
Query: 636 QAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQV-EQHRAVKLHNNQLISELESSVI 694
QAEQLS + A ++++ + ++ EL ++ E AVK I+ LE+ +
Sbjct: 1765 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1824
Query: 695 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQ---ELRTVKR 751
+LEEQ R+ + TK +K++ ++ + ++ +A K +A++ ++ +KR
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1884
Query: 752 KLLEEEEKNAR-------LQKELGD 769
+L E EE++ R LQ+EL +
Sbjct: 1885 QLEEAEEESQRINANRRKLQRELDE 1909
Score = 85.1 bits (209), Expect = 2e-16
Identities = 102/466 (21%), Positives = 201/466 (43%), Gaps = 84/466 (18%)
Query: 366 SELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETS 425
+E L L +K ++ E + E+LQA + ++ ++M L A+ ++L + +E
Sbjct: 871 AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR 930
Query: 426 FHQHRERAEQLSQENEKL---MNLLQERVKNE---------EPTTQEGKIIELEQKCTGI 473
+ +R +QL E +K+ M L+E+++ E E T E KI +LE + +
Sbjct: 931 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 990
Query: 474 LEQ-GRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNM 532
+Q + +E+ L ++++++ + EE + A + K LK ++E + LE+
Sbjct: 991 DDQNNKLSKERKL-LEERISDLTTNLAEEEEKAKNLTK-LKNKHESMISELEVRLKKEEK 1048
Query: 533 MAKTLEECRVTLEG------------------LKMENGSLKSHLQGEKQKATEASAVEQT 574
+ LE+ + LEG LKM+ + LQ + + A +
Sbjct: 1049 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1108
Query: 575 A---------ESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV-------SSL 618
A ++QE L RA ++ E +L +EL E++ L
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168
Query: 619 LAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMK----ETIFELEDQVEQ 674
AK E++ + LK+ D E+ +A++++M+ + + EL +Q+EQ
Sbjct: 1169 RAKREQEVTVLKKALD--------------EETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 675 HRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQ----- 729
+ K + L+ + LE++ +DL +L+ L + +E + ++ +A +Q
Sbjct: 1215 FKRAK-------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267
Query: 730 -----TAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDV 770
A ND + Q E+ +V L E E K +L K++ +
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Score = 82.0 bits (201), Expect = 2e-15
Identities = 91/393 (23%), Positives = 180/393 (45%), Gaps = 49/393 (12%)
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 435
++ + EE + +ELQ T + + ++EL ++ +L +EK +L+ EQ
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ----------EQ 895
Query: 436 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 495
L E E + RV ++ +Q+ IL + E+ + QQL
Sbjct: 896 LQAETELYAEAEEMRV----------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 945
Query: 496 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 555
+K+ ++ L++ ++L+EE E + L+LE+ K LE+ E L M++ +
Sbjct: 946 KKMAQQ---MLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLED-----EILVMDD---Q 993
Query: 556 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV 615
++ +++K E + T E +E K K+ E +EL L K + +
Sbjct: 994 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1053
Query: 616 SSLLAKVEKDYS-YLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQ 674
L K+E D S + ++I D QA Q++ ++L +K E A + + + I + + +++
Sbjct: 1054 EKLKRKLEGDASDFHEQIADLQA-QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 675 HRAVKLHNNQLISELESSVI---KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 731
R ++ H + L +L+S K E+QK DL +L+ L +++ D +
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-----------DTLDS 1161
Query: 732 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQ 764
+++ + +QE+ TV +K L+EE ++ Q
Sbjct: 1162 TATQQELRAKREQEV-TVLKKALDEETRSHEAQ 1193
Score = 78.6 bits (192), Expect = 2e-14
Identities = 141/664 (21%), Positives = 259/664 (39%), Gaps = 99/664 (14%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEK---RTLNAEGTDALGPNVDGTSVS 218
EK E+++++L E D + N+L E K +E+ T N + N+
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK-- 1029
Query: 219 PGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAAS--HTGDSSCP 276
E MI LE + K +K +LE+ LK KL EG AS H +
Sbjct: 1030 -NKHESMISELEVRLKKEEKSRQELEK----LKRKL---------EGDASDFHEQIADLQ 1075
Query: 277 TSITQESSFGSPTGNQMSSDIDEYKKNI--HGNALRTSGSSSSDVTKASLSPDASDFEHI 334
I + + ++ + + I NAL+ ++ D+
Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1135
Query: 335 TAETPSRPLSSTSNPFKSSKCSTAGSSPNS----------VSELSLA------SLTEKIQ 378
AE R L K+ T S+ V+ L A S ++Q
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 379 KMEENHHSTAEELQATLQEL----SDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 434
+M + H EEL L++ ++ + Q L EN L E +L Q ++ E
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG----QAKQEVE 1251
Query: 435 QLSQENEKLMNLLQERVKNEEPTTQE--GKIIELE---QKCTGILEQGRFEREKLLNIQQ 489
++ E + LQ + + E E K+ +L+ + TG+L + + KL
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1311
Query: 490 QLTCSLRKVEEENQGALEMIKRLKEENEKLN---EFLELERHNNNMMAKTLEECRVTLEG 546
L+ L+ +E Q +E +KLN + +LE N++ + EE +
Sbjct: 1312 SLSSQLQDTQELLQ---------EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK-QN 1361
Query: 547 LKMENGSLKSHLQGEKQKATE-ASAVEQTAESCE--------VQEMLKVARAEKDLLELS 597
L+ +L L K+K + AS VE E + + + + A D LE +
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1421
Query: 598 CNELRQELLKANGEIKHVSSLLAKVEKDYSYL-------KEICDHQAEQLSRTSLKLQEK 650
N L+QEL ++ + L++ +EK K I A++ R + +EK
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 651 ASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLIS---ELESSVIKLEEQKSDLERQL 707
+++ + + ++E + E+ ++ +K L+S ++ +V +LE+ K LE Q+
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541
Query: 708 KTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVK----RKLLEEEEKNARL 763
+ + Q++E L+ + D K + ++ +K R L +E+N
Sbjct: 1542 EEMKTQLEE-----------LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 764 QKEL 767
+++L
Sbjct: 1591 RRQL 1594
Score = 71.6 bits (174), Expect = 3e-12
Identities = 127/617 (20%), Positives = 252/617 (40%), Gaps = 73/617 (11%)
Query: 152 TKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPN 211
T+ + E +K + +++R+L + E N L+ +L + E + L
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQL-------EEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 212 VDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTG 271
+ + D + ALEE K FQKE+ +L ++ +EK + ++
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ---YEEKAAAYDKLEKTKNRLQQEL 1429
Query: 272 DSSCPTSITQESSFGSPTGNQMSSD-IDEYKKNIHGNAL----RTSGSSSSDVTKASLSP 326
D Q + Q D + +KNI R + TKA LS
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA-LSL 1488
Query: 327 DASDFEHITA----ETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEE 382
+ E + A E ++ L + SSK G + + + E S +L ++++M+
Sbjct: 1489 ARALEEALEAKEELERTNKMLKAEMEDLVSSK-DDVGKNVHEL-EKSKRALETQMEEMKT 1546
Query: 383 NHHSTAEELQAT----------LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRER 432
+ELQAT +Q L Q + ++L A +E+ +++ L+ H++
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQARDEQNEEKRRQLQRQLHEYETE 1604
Query: 433 AEQLSQEN-------EKLMNLLQE-------RVKNEEPTTQEGKIIELEQK-CTGILEQG 477
E ++ +KL L++ +K E ++ + ++ + K LE
Sbjct: 1605 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1664
Query: 478 RFEREKLLNIQQQ-------LTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNN 530
R R+++ ++ L L +++E+ A K+ E E+L E L
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 531 NMMA--KTLEECRVTL--EGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKV 586
N + K E R+ E L+ E G++++ + +KAT+ A + + E + +
Sbjct: 1725 NALQDEKRRLEARIAQLEEELEEEQGNMEA-MSDRVRKATQ-QAEQLSNELATERSTAQK 1782
Query: 587 ARAEKDLLELSCNELRQELLKANGEIKH-VSSLLAKVEKDYSYLKEICDHQAEQLSRTSL 645
+ + LE ELR +L + G +K S +A +E + L+E + +A + +
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 646 KLQEKASESDAEIKDMKETIFELEDQ---VEQHRAVKLHNNQLISELESSVIKLEEQKSD 702
L++K K +KE + ++ED+ EQ++ N + +L+ + + EE+
Sbjct: 1843 SLKQKD-------KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Query: 703 LERQLKTLTKQMKEETE 719
+ + L +++ E TE
Sbjct: 1896 INANRRKLQRELDEATE 1912
Score = 65.1 bits (157), Expect = 2e-10
Identities = 62/282 (21%), Positives = 125/282 (44%), Gaps = 26/282 (9%)
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNE---FLELERHNNNMMAKTLEECRVTLEGLKMEN 551
L+K +E Q A +K L++++ +L E L+ + + EE RV L K E
Sbjct: 861 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 920
Query: 552 GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 611
+ ++ ++ + Q Q+ML + E+ L E + +L K E
Sbjct: 921 EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL---EEQLEEEEAARQKLQLEKVTAE 977
Query: 612 IKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQ 671
K + K+E + + D Q +LS+ L+E+ I D+ + E E++
Sbjct: 978 AK-----IKKLEDEIL----VMDDQNNKLSKERKLLEER-------ISDLTTNLAEEEEK 1021
Query: 672 VEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 731
+ +K + +ISELE + K E+ + +LE+ L ++++ + ++ ADLQ
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEK----LKRKLEGDASDFHEQIADLQAQ 1077
Query: 732 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGH 773
+ + ++EL+ +L +E + K++ +++GH
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1119
Score = 52.8 bits (125), Expect = 1e-06
Identities = 84/434 (19%), Positives = 186/434 (42%), Gaps = 41/434 (9%)
Query: 153 KPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNV 212
K + E+ K + V EL +A ++++ ++++L++ +++ + L N+
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1569
Query: 213 DGTSVSPGDTEPMIRALEEKNKNFQKEL--------SDLEEENRVLKEKLIYLEHSPNSE 264
G E ++A +E+N+ +++L ++LE+E K++ + E
Sbjct: 1570 QALK---GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER---KQRALAAAAKKKLE 1623
Query: 265 GAASHTGDSSCPTSITQESSFGSPTGNQMS-SDIDEYKKNIHGNALRTSGSSSSDVTKA- 322
G + +E + Q D ++ + ++ + KA
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683
Query: 323 SLSPDASDF-EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME 381
SL D E + A +R + + + +++ S N++ + L +I ++E
Sbjct: 1684 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD-EKRRLEARIAQLE 1742
Query: 382 ENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENE 441
E EE Q ++ +SD+ V++ T + E+L +E ++ ++ +QL ++N+
Sbjct: 1743 EE----LEEEQGNMEAMSDR---VRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1795
Query: 442 KLMNLLQER---VKNEEPTT---QEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 495
+L + L E VK++ +T E KI +LE++ + + + L ++L L
Sbjct: 1796 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855
Query: 496 RKVEEENQGALEM----------IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLE 545
+VE+E + A + +K+LK + E+ E + N + + L+E + E
Sbjct: 1856 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Query: 546 GLKMENGSLKSHLQ 559
+ E +LKS L+
Sbjct: 1916 AMGREVNALKSKLR 1929
Score = 52.4 bits (124), Expect = 2e-06
Identities = 111/597 (18%), Positives = 238/597 (39%), Gaps = 65/597 (10%)
Query: 109 REFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALES 168
++F+ TV ++ G +K + + T + + TK + + E +
Sbjct: 1381 QDFASTVE---ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437
Query: 169 QVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRA 228
R+L++ + K + ++L +E K K + +A + ++S + RA
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS------LARA 1491
Query: 229 LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSP 288
LEE + KE +LE N++LK ++ L S + G H + S TQ +
Sbjct: 1492 LEEALE--AKE--ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 289 TGNQMSSDI---DEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSS 345
++ ++ ++ K + N G D+ A D ++ E R L
Sbjct: 1548 L-EELEDELQATEDAKLRLEVNMQALKGQFERDL-------QARDEQN---EEKRRQLQR 1596
Query: 346 TSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMV 405
+ +++ +++ + L ++ +E S + + +++L Q +
Sbjct: 1597 QLHEYETELEDER--KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1654
Query: 406 QELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQ--ERVKNEEPTTQEGKI 463
++ E E + + + ++ ++A+ L + +L L ER + + +E
Sbjct: 1655 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1714
Query: 464 IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEE---NQGALEM----IKRLKEEN 516
EL +G R L + +++L + ++EEE QG +E +++ ++
Sbjct: 1715 EELASSLSG--------RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766
Query: 517 EKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAE 576
E+L+ L ER A+ E R LE E S ++G + +++ A+
Sbjct: 1767 EQLSNELATERST----AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822
Query: 577 SCEVQEMLKVARAEKDLLELSCNE----LRQELLKANGEIKHVSSLLAKVEKDYSYLKEI 632
+++E ++ EK S + L++ LL+ E K + EK + +K
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK-- 1880
Query: 633 CDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISEL 689
QL R + +E++ +A + ++ EL++ E + A+ N L S+L
Sbjct: 1881 ------QLKRQLEEAEEESQRINANRRKLQR---ELDEATESNEAMGREVNALKSKL 1928
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 90.9 bits (224), Expect = 4e-18
Identities = 181/805 (22%), Positives = 325/805 (40%), Gaps = 99/805 (12%)
Query: 33 KSSKSSTSLAFESRLSRLKRASSEDTLNKPGSTAASGVVRLKKTATAGAISELTESRLRS 92
K+ K L E L LK EDTL+ STA +R K+ + + + RS
Sbjct: 1143 KAEKQKRDLGEE--LEALK-TELEDTLD---STATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 93 GTGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPST 152
++ A E + + + + R +N K+ + N + LR
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFK---RAKANLDKNKQTLEKENADLAGE-LRVLG- 1251
Query: 153 KPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNV 212
+ KQE E +K LE+QV+EL ++K D E R R+EL K E +
Sbjct: 1252 QAKQEVEH-KKKKLEAQVQEL--QSKCSDGE--RARAELNDKVHKLQNEVESVTGMLNEA 1306
Query: 213 DGTSVSPG-----------DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIY-LEHS 260
+G ++ DT+ +++ + N +L LEEE L+++L +E
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Query: 261 PNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSS--- 317
N E S T + S + F S T + ++K I + +++
Sbjct: 1367 QNLERHIS-TLNIQLSDSKKKLQDFAS-TVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1424
Query: 318 -DVTKASLSPDASDFEHITAETPSRPLSST----SNPFKSSKCSTAGSSPNSVSELSLAS 372
+ TK L + D + R L S F S E A
Sbjct: 1425 LEKTKNRLQQELDDL--VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 373 LTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRER 432
+ ++ E S A L+ L+ + ++ + L AE E LV K + + H+ +
Sbjct: 1483 A--EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 433 AEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFER----------E 482
L + E++ L+E +++E T++ K+ LE + +G+FER E
Sbjct: 1541 KRALETQMEEMKTQLEE-LEDELQATEDAKL-RLEVNMQAL--KGQFERDLQARDEQNEE 1596
Query: 483 KLLNIQQQLTCSLRKVEEEN-QGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECR 541
K +Q+QL ++E+E Q AL + K E + + LEL+ + K EE
Sbjct: 1597 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD--LELQADS---AIKGREEAI 1651
Query: 542 VTLEGLKMENGSLKSHLQGEKQ---------KATEASAVEQTAESCEVQEMLKVARAEKD 592
L L+ + + L+ + K E A A+ ++QE L A +
Sbjct: 1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711
Query: 593 LLELSCNELRQEL---LKANGEIK--------HVSSLLAKVEKDYSYLKEICDH------ 635
+L EL +EL L ++ ++ L ++E++ ++ + D
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 636 QAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQV-EQHRAVKLHNNQLISELESSVI 694
QAEQLS + A ++++ + ++ EL ++ E AVK I+ LE+ +
Sbjct: 1772 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1831
Query: 695 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQ---ELRTVKR 751
+LEEQ R+ + TK +K++ ++ + ++ +A K +A++ ++ +KR
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1891
Query: 752 KLLEEEEKNAR-------LQKELGD 769
+L E EE++ R LQ+EL +
Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDE 1916
Score = 85.1 bits (209), Expect = 2e-16
Identities = 102/466 (21%), Positives = 201/466 (43%), Gaps = 84/466 (18%)
Query: 366 SELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETS 425
+E L L +K ++ E + E+LQA + ++ ++M L A+ ++L + +E
Sbjct: 878 AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR 937
Query: 426 FHQHRERAEQLSQENEKL---MNLLQERVKNE---------EPTTQEGKIIELEQKCTGI 473
+ +R +QL E +K+ M L+E+++ E E T E KI +LE + +
Sbjct: 938 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 997
Query: 474 LEQ-GRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNM 532
+Q + +E+ L ++++++ + EE + A + K LK ++E + LE+
Sbjct: 998 DDQNNKLSKERKL-LEERISDLTTNLAEEEEKAKNLTK-LKNKHESMISELEVRLKKEEK 1055
Query: 533 MAKTLEECRVTLEG------------------LKMENGSLKSHLQGEKQKATEASAVEQT 574
+ LE+ + LEG LKM+ + LQ + + A +
Sbjct: 1056 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1115
Query: 575 A---------ESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV-------SSL 618
A ++QE L RA ++ E +L +EL E++ L
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1175
Query: 619 LAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMK----ETIFELEDQVEQ 674
AK E++ + LK+ D E+ +A++++M+ + + EL +Q+EQ
Sbjct: 1176 RAKREQEVTVLKKALD--------------EETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 675 HRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQ----- 729
+ K + L+ + LE++ +DL +L+ L + +E + ++ +A +Q
Sbjct: 1222 FKRAK-------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274
Query: 730 -----TAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDV 770
A ND + Q E+ +V L E E K +L K++ +
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Score = 82.0 bits (201), Expect = 2e-15
Identities = 91/393 (23%), Positives = 180/393 (45%), Gaps = 49/393 (12%)
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 435
++ + EE + +ELQ T + + ++EL ++ +L +EK +L+ EQ
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ----------EQ 902
Query: 436 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 495
L E E + RV ++ +Q+ IL + E+ + QQL
Sbjct: 903 LQAETELYAEAEEMRV----------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 952
Query: 496 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 555
+K+ ++ L++ ++L+EE E + L+LE+ K LE+ E L M++ +
Sbjct: 953 KKMAQQ---MLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLED-----EILVMDD---Q 1000
Query: 556 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV 615
++ +++K E + T E +E K K+ E +EL L K + +
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1060
Query: 616 SSLLAKVEKDYS-YLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQ 674
L K+E D S + ++I D QA Q++ ++L +K E A + + + I + + +++
Sbjct: 1061 EKLKRKLEGDASDFHEQIADLQA-QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 675 HRAVKLHNNQLISELESSVI---KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 731
R ++ H + L +L+S K E+QK DL +L+ L +++ D +
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-----------DTLDS 1168
Query: 732 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQ 764
+++ + +QE+ TV +K L+EE ++ Q
Sbjct: 1169 TATQQELRAKREQEV-TVLKKALDEETRSHEAQ 1200
Score = 78.6 bits (192), Expect = 2e-14
Identities = 141/664 (21%), Positives = 259/664 (39%), Gaps = 99/664 (14%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEK---RTLNAEGTDALGPNVDGTSVS 218
EK E+++++L E D + N+L E K +E+ T N + N+
Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK-- 1036
Query: 219 PGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAAS--HTGDSSCP 276
E MI LE + K +K +LE+ LK KL EG AS H +
Sbjct: 1037 -NKHESMISELEVRLKKEEKSRQELEK----LKRKL---------EGDASDFHEQIADLQ 1082
Query: 277 TSITQESSFGSPTGNQMSSDIDEYKKNI--HGNALRTSGSSSSDVTKASLSPDASDFEHI 334
I + + ++ + + I NAL+ ++ D+
Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1142
Query: 335 TAETPSRPLSSTSNPFKSSKCSTAGSSPNS----------VSELSLA------SLTEKIQ 378
AE R L K+ T S+ V+ L A S ++Q
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 379 KMEENHHSTAEELQATLQEL----SDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 434
+M + H EEL L++ ++ + Q L EN L E +L Q ++ E
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG----QAKQEVE 1258
Query: 435 QLSQENEKLMNLLQERVKNEEPTTQE--GKIIELE---QKCTGILEQGRFEREKLLNIQQ 489
++ E + LQ + + E E K+ +L+ + TG+L + + KL
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1318
Query: 490 QLTCSLRKVEEENQGALEMIKRLKEENEKLN---EFLELERHNNNMMAKTLEECRVTLEG 546
L+ L+ +E Q +E +KLN + +LE N++ + EE +
Sbjct: 1319 SLSSQLQDTQELLQ---------EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK-QN 1368
Query: 547 LKMENGSLKSHLQGEKQKATE-ASAVEQTAESCE--------VQEMLKVARAEKDLLELS 597
L+ +L L K+K + AS VE E + + + + A D LE +
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1428
Query: 598 CNELRQELLKANGEIKHVSSLLAKVEKDYSYL-------KEICDHQAEQLSRTSLKLQEK 650
N L+QEL ++ + L++ +EK K I A++ R + +EK
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 651 ASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLIS---ELESSVIKLEEQKSDLERQL 707
+++ + + ++E + E+ ++ +K L+S ++ +V +LE+ K LE Q+
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548
Query: 708 KTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVK----RKLLEEEEKNARL 763
+ + Q++E L+ + D K + ++ +K R L +E+N
Sbjct: 1549 EEMKTQLEE-----------LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 764 QKEL 767
+++L
Sbjct: 1598 RRQL 1601
Score = 71.6 bits (174), Expect = 3e-12
Identities = 127/617 (20%), Positives = 252/617 (40%), Gaps = 73/617 (11%)
Query: 152 TKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPN 211
T+ + E +K + +++R+L + E N L+ +L + E + L
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQL-------EEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 212 VDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTG 271
+ + D + ALEE K FQKE+ +L ++ +EK + ++
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ---YEEKAAAYDKLEKTKNRLQQEL 1436
Query: 272 DSSCPTSITQESSFGSPTGNQMSSD-IDEYKKNIHGNAL----RTSGSSSSDVTKASLSP 326
D Q + Q D + +KNI R + TKA LS
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA-LSL 1495
Query: 327 DASDFEHITA----ETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEE 382
+ E + A E ++ L + SSK G + + + E S +L ++++M+
Sbjct: 1496 ARALEEALEAKEELERTNKMLKAEMEDLVSSK-DDVGKNVHEL-EKSKRALETQMEEMKT 1553
Query: 383 NHHSTAEELQAT----------LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRER 432
+ELQAT +Q L Q + ++L A +E+ +++ L+ H++
Sbjct: 1554 QLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQARDEQNEEKRRQLQRQLHEYETE 1611
Query: 433 AEQLSQEN-------EKLMNLLQE-------RVKNEEPTTQEGKIIELEQK-CTGILEQG 477
E ++ +KL L++ +K E ++ + ++ + K LE
Sbjct: 1612 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1671
Query: 478 RFEREKLLNIQQQ-------LTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNN 530
R R+++ ++ L L +++E+ A K+ E E+L E L
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731
Query: 531 NMMA--KTLEECRVTL--EGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKV 586
N + K E R+ E L+ E G++++ + +KAT+ A + + E + +
Sbjct: 1732 NALQDEKRRLEARIAQLEEELEEEQGNMEA-MSDRVRKATQ-QAEQLSNELATERSTAQK 1789
Query: 587 ARAEKDLLELSCNELRQELLKANGEIKH-VSSLLAKVEKDYSYLKEICDHQAEQLSRTSL 645
+ + LE ELR +L + G +K S +A +E + L+E + +A + +
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 646 KLQEKASESDAEIKDMKETIFELEDQ---VEQHRAVKLHNNQLISELESSVIKLEEQKSD 702
L++K K +KE + ++ED+ EQ++ N + +L+ + + EE+
Sbjct: 1850 SLKQKD-------KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Query: 703 LERQLKTLTKQMKEETE 719
+ + L +++ E TE
Sbjct: 1903 INANRRKLQRELDEATE 1919
Score = 65.1 bits (157), Expect = 2e-10
Identities = 62/282 (21%), Positives = 125/282 (44%), Gaps = 26/282 (9%)
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNE---FLELERHNNNMMAKTLEECRVTLEGLKMEN 551
L+K +E Q A +K L++++ +L E L+ + + EE RV L K E
Sbjct: 868 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 927
Query: 552 GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 611
+ ++ ++ + Q Q+ML + E+ L E + +L K E
Sbjct: 928 EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL---EEQLEEEEAARQKLQLEKVTAE 984
Query: 612 IKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQ 671
K + K+E + + D Q +LS+ L+E+ I D+ + E E++
Sbjct: 985 AK-----IKKLEDEIL----VMDDQNNKLSKERKLLEER-------ISDLTTNLAEEEEK 1028
Query: 672 VEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 731
+ +K + +ISELE + K E+ + +LE+ L ++++ + ++ ADLQ
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEK----LKRKLEGDASDFHEQIADLQAQ 1084
Query: 732 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGH 773
+ + ++EL+ +L +E + K++ +++GH
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1126
Score = 52.8 bits (125), Expect = 1e-06
Identities = 84/434 (19%), Positives = 186/434 (42%), Gaps = 41/434 (9%)
Query: 153 KPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNV 212
K + E+ K + V EL +A ++++ ++++L++ +++ + L N+
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1576
Query: 213 DGTSVSPGDTEPMIRALEEKNKNFQKEL--------SDLEEENRVLKEKLIYLEHSPNSE 264
G E ++A +E+N+ +++L ++LE+E K++ + E
Sbjct: 1577 QALK---GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER---KQRALAAAAKKKLE 1630
Query: 265 GAASHTGDSSCPTSITQESSFGSPTGNQMS-SDIDEYKKNIHGNALRTSGSSSSDVTKA- 322
G + +E + Q D ++ + ++ + KA
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690
Query: 323 SLSPDASDF-EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME 381
SL D E + A +R + + + +++ S N++ + L +I ++E
Sbjct: 1691 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD-EKRRLEARIAQLE 1749
Query: 382 ENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENE 441
E EE Q ++ +SD+ V++ T + E+L +E ++ ++ +QL ++N+
Sbjct: 1750 EE----LEEEQGNMEAMSDR---VRKATQQAEQLSNELATERSTAQKNESARQQLERQNK 1802
Query: 442 KLMNLLQER---VKNEEPTT---QEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 495
+L + L E VK++ +T E KI +LE++ + + + L ++L L
Sbjct: 1803 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862
Query: 496 RKVEEENQGALEM----------IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLE 545
+VE+E + A + +K+LK + E+ E + N + + L+E + E
Sbjct: 1863 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Query: 546 GLKMENGSLKSHLQ 559
+ E +LKS L+
Sbjct: 1923 AMGREVNALKSKLR 1936
Score = 52.4 bits (124), Expect = 2e-06
Identities = 111/597 (18%), Positives = 238/597 (39%), Gaps = 65/597 (10%)
Query: 109 REFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALES 168
++F+ TV ++ G +K + + T + + TK + + E +
Sbjct: 1388 QDFASTVE---ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444
Query: 169 QVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRA 228
R+L++ + K + ++L +E K K + +A + ++S + RA
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS------LARA 1498
Query: 229 LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSP 288
LEE + KE +LE N++LK ++ L S + G H + S TQ +
Sbjct: 1499 LEEALE--AKE--ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 289 TGNQMSSDI---DEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSS 345
++ ++ ++ K + N G D+ A D ++ E R L
Sbjct: 1555 L-EELEDELQATEDAKLRLEVNMQALKGQFERDL-------QARDEQN---EEKRRQLQR 1603
Query: 346 TSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMV 405
+ +++ +++ + L ++ +E S + + +++L Q +
Sbjct: 1604 QLHEYETELEDER--KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1661
Query: 406 QELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQ--ERVKNEEPTTQEGKI 463
++ E E + + + ++ ++A+ L + +L L ER + + +E
Sbjct: 1662 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 464 IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEE---NQGALEM----IKRLKEEN 516
EL +G R L + +++L + ++EEE QG +E +++ ++
Sbjct: 1722 EELASSLSG--------RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773
Query: 517 EKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAE 576
E+L+ L ER A+ E R LE E S ++G + +++ A+
Sbjct: 1774 EQLSNELATERST----AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829
Query: 577 SCEVQEMLKVARAEKDLLELSCNE----LRQELLKANGEIKHVSSLLAKVEKDYSYLKEI 632
+++E ++ EK S + L++ LL+ E K + EK + +K
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK-- 1887
Query: 633 CDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISEL 689
QL R + +E++ +A + ++ EL++ E + A+ N L S+L
Sbjct: 1888 ------QLKRQLEEAEEESQRINANRRKLQR---ELDEATESNEAMGREVNALKSKL 1935
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 90.1 bits (222), Expect = 7e-18
Identities = 97/418 (23%), Positives = 192/418 (45%), Gaps = 29/418 (6%)
Query: 367 ELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSF 426
E L + K Q++ E + AE+LQA + ++ ++M L A+ ++L + LE+
Sbjct: 872 EGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRV 931
Query: 427 HQHRERAEQLSQENEKL---MNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREK 483
+ ER + L E +K+ + L+E++ EE Q+ ++LE K T + + E E
Sbjct: 932 EEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQK---LQLE-KVTAEAKIKKMEEEI 987
Query: 484 LLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVT 543
LL ++ Q + +++ + E +L EE EK ++ R+ +M LEE
Sbjct: 988 LL-LEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKI-RNKQEVMISDLEERLKK 1045
Query: 544 LEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQ 603
E + E K L GE +Q AE + LK+ A+K+ EL+
Sbjct: 1046 EEKTRQELEKAKRKLDGE-----TTDLQDQIAELQAQIDELKLQLAKKE------EELQG 1094
Query: 604 ELLKANGEIKHVSSLLAKVEKDYSYLKEIC-DHQAEQLSRTSLKLQEKASESDAEIKDMK 662
L + + E H ++ L V + + + E+ D ++E+ SR K +++ + E++ +K
Sbjct: 1095 ALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRN--KAEKQKRDLSEELEALK 1152
Query: 663 ETIFELEDQVEQHRAVKLHNNQLISE----LESSVIKLEEQKSDLERQLKTLTKQMKEET 718
+ + D + ++ Q ++E LE E Q D+ ++ T +++ E+
Sbjct: 1153 TELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQL 1212
Query: 719 EEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRV 776
E+ +RF+A+L+ E E++ +++ E E K +L ++ ++ H +V
Sbjct: 1213 EQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL--HAKV 1268
Score = 88.2 bits (217), Expect = 3e-17
Identities = 149/677 (22%), Positives = 281/677 (41%), Gaps = 104/677 (15%)
Query: 162 EKAALESQVRELLAEAKAK--DSEINRLRSELKKY-KEKRTLN---AEGTDALGPNVD-- 213
E A + Q+ ++ AEAK K + EI L + K+ KEK+ + AE + L +
Sbjct: 963 EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA 1022
Query: 214 -GTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGD 272
+ E MI LEE+ K +K +LE+ R L + L+ + A
Sbjct: 1023 KNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ----DQIAELQAQI 1078
Query: 273 SSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFE 332
+ ++ G D + KN NAL+ + + + ++
Sbjct: 1079 DELKLQLAKKEE--ELQGALARGDDETLHKN---NALKVVRELQAQIAELQEDFESEKAS 1133
Query: 333 HITAETPSRPLSSTSNPFKSSKCSTAGSSP-----NSVSELSLASLTEKIQKMEENHHST 387
AE R LS K+ T ++ + E +A L + +++ +NH +
Sbjct: 1134 RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQ 1193
Query: 388 AEELQ----ATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERA------EQLS 437
++++ L+ELS+Q + + A EK K LET ++E A +Q+
Sbjct: 1194 IQDMRQRHATALEELSEQLEQAKRFKANLEK---NKQGLETD---NKELACEVKVLQQVK 1247
Query: 438 QENEKLMNLLQERVKNEEPTTQEGKIIELE------------QKCTGILEQGRFEREKLL 485
E+E L +V+ EG + +E + +LE+ + K
Sbjct: 1248 AESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFA 1307
Query: 486 ----NIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECR 541
+++ QL + ++EE + L + R+++ E+ N E + EE R
Sbjct: 1308 KDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE--------EEAR 1359
Query: 542 VTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARA------EK---- 591
LE + +L+S L K+K + ++ E + +++LK A A EK
Sbjct: 1360 KNLEKQVL---ALQSQLADTKKKVDDDLGTIESLEEAK-KKLLKDAEALSQRLEEKALAY 1415
Query: 592 DLLELSCNELRQELLKANGEIKH---VSSLLAKVEKDYSYL----KEICDHQAEQLSRTS 644
D LE + N L+QEL ++ H V+S L K +K + L K I AE+ R
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475
Query: 645 LKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLIS----------ELESSVI 694
+ +EK +++ + + ++E + E+ Q++ ++ L+S ELE S
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535
Query: 695 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL 754
LE+Q ++ QL+ L +++ + R + ++Q +K + +++L+T
Sbjct: 1536 ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQA-------MKAQFERDLQTRDE--- 1585
Query: 755 EEEEKNARLQKELGDVQ 771
+ EEK L K++ +++
Sbjct: 1586 QNEEKKRLLIKQVRELE 1602
Score = 82.8 bits (203), Expect = 1e-15
Identities = 167/842 (19%), Positives = 332/842 (39%), Gaps = 117/842 (13%)
Query: 29 SSGMKSSKSSTSLAFESRLSRLKRASSEDTLNKPGSTAASGVVRLKKTATAGAISELTES 88
+S K+ K L+ E L LK EDTL+ +TAA +R K+ + + E
Sbjct: 1132 ASRNKAEKQKRDLSEE--LEALK-TELEDTLD---TTAAQQELRTKREQEVAELKKALEE 1185
Query: 89 RLRSGTGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLR 148
++ ++ A E S + + + R +N K+ + N +
Sbjct: 1186 ETKNHEAQIQDMRQRHATALEELSEQLEQAK---RFKANLEKNKQGLETDNKELACEVKV 1242
Query: 149 TPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDAL 208
K + E++ + L++QV+EL AK SE +RLR EL + K + L
Sbjct: 1243 LQQVKAESEHK---RKKLDAQVQEL----HAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295
Query: 209 GPNVDGTSVSPG-----------DTEPM--------------IRALEEKNKNFQKELSDL 243
+ + DT+ + IR LEE+ + Q++ +
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355
Query: 244 EEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKN 303
EE + L+++++ L+ S ++ D S+ + +S ++E K
Sbjct: 1356 EEARKNLEKQVLALQ-SQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE-KAL 1413
Query: 304 IHGNALRTSGSSSSDV------------TKASLSPDASDFEHITAETPSRPLSSTSNPFK 351
+ +T ++ ++L F+ + AE S ++ +
Sbjct: 1414 AYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS----ISARYAE 1469
Query: 352 SSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAE 411
+ A + LSLA E+ + +E ++L+A +++L + V + E
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE 1529
Query: 412 NEKLVDEKTILETSFHQHRERAEQLSQE-------------NEKLMNLLQER---VKNEE 455
EK K LE + R + E+L E N + M ER ++E+
Sbjct: 1530 LEK---SKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQ 1586
Query: 456 PTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLR----KVEEENQGALEMIKR 511
++ +I+ ++ LE R +R + ++++ L+ ++E N+ E+IK+
Sbjct: 1587 NEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ 1646
Query: 512 LKEENEKLNEF---LELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEA 568
L++ ++ ++ LE R + + + +E L+ L+ E L+ L ++A
Sbjct: 1647 LRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEEL-ASSERARRH 1705
Query: 569 SAVEQTAESCEVQEMLKVARA---EKDLLELSCNELRQELLKANGEIK-----------H 614
+ E+ + E+ A EK LE +L +EL + ++
Sbjct: 1706 AEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ 1765
Query: 615 VSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKD--------MKETIF 666
V +L A++ + S ++ D+ +QL R + +L+ K E + +K ++ I
Sbjct: 1766 VDTLNAELAAERSAAQK-SDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIG 1824
Query: 667 ELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQA 726
+LE+Q+EQ + N+L+ E + ++ Q D R +QM++ ++ +
Sbjct: 1825 QLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKR 1884
Query: 727 DLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPSL 786
L+ A A A R ++R+L + E N L +E+ ++ R R P S
Sbjct: 1885 QLEEAEEEAT----RANASRRKLQRELDDATEANEGLSREVSTLKNRLR----RGGPISF 1936
Query: 787 GS 788
S
Sbjct: 1937 SS 1938
Score = 50.4 bits (119), Expect = 6e-06
Identities = 70/305 (22%), Positives = 130/305 (42%), Gaps = 43/305 (14%)
Query: 466 LEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLN-EFLE 524
L++ C L+ ++ ++ + L R+ EEE Q E + ++KE+ K+ E E
Sbjct: 819 LQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQ-EEELQAKDEELLKVKEKQTKVEGELEE 877
Query: 525 LERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEML 584
+ER + ++ E L LQ E + EA +EM
Sbjct: 878 MERKHQQLLE---------------EKNILAEQLQAETELFAEA------------EEMR 910
Query: 585 KVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTS 644
A+K LE ++L + + + + + K++ L+E D E+ +R
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE--EEGARQK 968
Query: 645 LKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDL- 703
L+L++ +E A+IK M+E I LEDQ + K I+E S + + EE+ +L
Sbjct: 969 LQLEKVTAE--AKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 1026
Query: 704 ------ERQLKTLTKQMKEE---TEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL 754
E + L +++K+E +E + + L D E Q ++ +K +L
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA 1086
Query: 755 EEEEK 759
++EE+
Sbjct: 1087 KKEEE 1091
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 90.1 bits (222), Expect = 7e-18
Identities = 170/739 (23%), Positives = 319/739 (43%), Gaps = 106/739 (14%)
Query: 110 EFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQ 169
E V +++ER + +P + S ++ +TP+PT L S++ KQ + E A +++
Sbjct: 208 ELIVDLTQERDYLQA-QHPPSPIKSSSADSTPSPTSSL---SSEDKQ-HLAVELADTKAR 262
Query: 170 VRELLAEAKAKDS-------EINRLRSELKKYKEKR---TLNAEGTDALGPNVDGTSVSP 219
+R + E + K E+++L EL+K K++ +A A +D
Sbjct: 263 LRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKA 322
Query: 220 GDTEPM---IRALEEKNKN---FQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDS 273
E + + +EK + ++ + +L E+N +L E LE AA GD
Sbjct: 323 NRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLT---AARARGDK 379
Query: 274 SCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS---D 330
+ +E+ + + D D KK I L K S++ A +
Sbjct: 380 --VHELEKENLQLKSKLHDLELDRDTDKKRI--EELLEENMVLEIAQKQSMNESAHLGWE 435
Query: 331 FEHITAETPSRPLSSTSNPFKSSKCSTA---------GSSPNSVSELSLASLT-----EK 376
E ++ S S F+ ++C+++ S +++ L ASL K
Sbjct: 436 LEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLK 495
Query: 377 IQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHR-ERAEQ 435
++E+ +H +++++ +L ++Q Q+L +E+L+ EK L++ + ++A Q
Sbjct: 496 CGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQ 555
Query: 436 ---LSQENEKLMNLLQE-RVKNEEPTTQEGKIIELEQK--------CTGILEQGRFEREK 483
L QE + L + R +++ + K +E E K G L Q FE+
Sbjct: 556 IKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEK-- 613
Query: 484 LLNIQQQLTCSLRKVEEENQGALEM---IKRLKEENEKL-NEFLELERHNNNMMAKTLEE 539
+QL L + +E+ + A ++ ++RL+EEN +L + LE + A E
Sbjct: 614 -----RQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHES 668
Query: 540 CRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQ-----TAESCEVQEMLKVARAEKDLL 594
+GL++EN +L+ L + + + +E+ AE+ E++ +++ R L
Sbjct: 669 -----QGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKL 723
Query: 595 ELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASES 654
E Q+L + E++ LL + K E + + +S +L+LQ+ S
Sbjct: 724 AQMERE-NQQLEREKEELRKNVDLLKALGKK----SERLELSYQSVSAENLRLQQSLESS 778
Query: 655 DAEIKDMKETIFELEDQVEQHR----AVKLHNNQL------ISELESSVIKLEEQKSDLE 704
+ + ++ + ELE + + R A++L N QL LE V +LE+ K LE
Sbjct: 779 SHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLE 838
Query: 705 RQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEA-QQEL---RTVKRKLLEEEEKN 760
++ K L +Q+ E + D TA + A + + A +EL R KL E E+ N
Sbjct: 839 KEAKRLWQQV-----ELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDN 893
Query: 761 ARLQKELGDVQGHGRVVTS 779
L K+ V H R +T+
Sbjct: 894 RDLTKQ---VTVHARTLTT 909
Score = 65.1 bits (157), Expect = 2e-10
Identities = 107/460 (23%), Positives = 182/460 (39%), Gaps = 82/460 (17%)
Query: 385 HSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFH-----QHRERAEQLSQE 439
H E+ + + ++ +Q L EN +L + T LET+ +H + QL
Sbjct: 617 HRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENR 676
Query: 440 N-EKLMNLLQERVKNEEPTTQEGKIIELEQ-KCTGILEQGRFEREKLLNIQQQLTCSLRK 497
K ++ LQ E ++ K ++ E + ++E RF KL ++++ L +
Sbjct: 677 TLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERE-NQQLER 735
Query: 498 VEEENQGALEMIKRLKE--------------ENEKLNEFLELERHNNNMMAKTLEEC--- 540
+EE + ++++K L + EN +L + LE H + L E
Sbjct: 736 EKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAE 795
Query: 541 ----RVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEV-------QEMLKVARA 589
R LE L++ N L+ + K E + +E+ + E Q LK A
Sbjct: 796 RQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVL 855
Query: 590 EKDLLELSCNELRQELL-KANGEIKHVSSLLAKVEKDYSYL-KEICDHQA------EQLS 641
+ +LS E L K + + L ++EKD L K++ H E L
Sbjct: 856 DDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLV 915
Query: 642 RTSLKLQEKASESDAEIKDMKET-----IFELEDQVEQHRAVKLHNNQLISEL------- 689
LK Q+ +SE D +++++ + ED K+ + S L
Sbjct: 916 LEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMK 975
Query: 690 ESSVIKLE---EQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIK------- 739
E ++ LE E+K+ L RQL++ + +K+E E R+ Q + Q + N K
Sbjct: 976 EEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQH---LQNSFKHPAGKTA 1032
Query: 740 -------------CEAQQELRTVKRKLLEEEEKNARLQKE 766
EA EL VK + +E E NA LQ E
Sbjct: 1033 ASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAE 1072
Score = 47.4 bits (111), Expect = 5e-05
Identities = 122/623 (19%), Positives = 238/623 (38%), Gaps = 108/623 (17%)
Query: 162 EKAALESQVREL-LAEAKAKDSEINR--LRSELKKYKEKRTLNAEGTDALGPNVDGTSVS 218
E+ AL + L LA A+ + +E +R L E+ + ++ + L + L V+
Sbjct: 795 ERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAV 854
Query: 219 PGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTS 278
D+ + A+E++++ KEL+ + LKE N + T + T+
Sbjct: 855 LDDSTAKLSAVEKESRALDKELARCRDAAGKLKEL-----EKDNRDLTKQVTVHARTLTT 909
Query: 279 ITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAET 338
+ ++ Q+SS++D+ S ++ K L+ +
Sbjct: 910 LREDLVLEKLKSQQLSSELDKL---------------SQELEKVGLNREL---------- 944
Query: 339 PSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME---ENHHSTAEELQATL 395
L + +K S + +LA EKI +E E S +L++ L
Sbjct: 945 ----LLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESEL 1000
Query: 396 QELSDQQQMVQELTAENEKLVDE-KTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE 454
Q L + + +++ E + L + K + H+ + E M LL RVK+
Sbjct: 1001 QMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELL--RVKD- 1057
Query: 455 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQ-QQLTCSLRKVEEENQGALEMIKRLK 513
+ IELE+ + + + +E+L +++ Q +T S + + + Q A
Sbjct: 1058 -------RAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAF------- 1103
Query: 514 EENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQ 573
L+ HN + +T + L++EN +L S +
Sbjct: 1104 -----------LQEHNTTLQTQTAK--------LQVENSTLSS------------QSAAL 1132
Query: 574 TAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEIC 633
TA+ +Q E + L+ +L + +H+ +L + +Y L I
Sbjct: 1133 TAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEAL--IR 1190
Query: 634 DHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSV 693
H + +L+L+ K E DM + ELE E+ + + L E ++
Sbjct: 1191 QHSCLKTLHRNLELEHK--ELGERHGDMLKRKAELE---EREKVLTTEREALQQEQRTNA 1245
Query: 694 IKLEEQ---KSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVK 750
+ + E + +L+R + L Q+K E EE +L+T++ AQ EL +
Sbjct: 1246 LAMGENQRLRGELDR-VNFLHHQLKGEYEELHAHTKELKTSL-------NNAQLELNRWQ 1297
Query: 751 RKLLEEEEKNARLQKELGDVQGH 773
+ E +E++ + L + H
Sbjct: 1298 ARFDELKEQHQTMDISLTKLDNH 1320
Score = 33.5 bits (75), Expect = 0.79
Identities = 23/76 (30%), Positives = 37/76 (48%), Gaps = 11/76 (14%)
Query: 381 EENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQEN 440
EENHH L + +Q LS Q QM+ E EN++ E+ Q+ ++ L +
Sbjct: 1333 EENHH-----LLSQIQLLSQQNQMLLEQNMENKEQYHEEQ------KQYIDKLNALRRHK 1381
Query: 441 EKLMNLLQERVKNEEP 456
EKL + ++ K +P
Sbjct: 1382 EKLEEKIMDQYKFYDP 1397
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 88.2 bits (217), Expect = 3e-17
Identities = 108/488 (22%), Positives = 217/488 (44%), Gaps = 93/488 (19%)
Query: 373 LTEKIQKMEEN---HHSTAEELQ-------ATLQELSDQQQMVQELTAENEKLVDEKTIL 422
+ + IQ++EE S ++LQ A L++L ++Q ++++ +N KL EK +L
Sbjct: 941 MQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILED---QNCKLAKEKKLL 997
Query: 423 E-------TSFHQHRERAEQLSQ---ENEKLMNLLQERVKNEEPTTQ---------EGKI 463
E T+ + E+++ L++ ++E ++ L+ER++ EE Q EG
Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057
Query: 464 IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEE---NQGALEMIKRLKEENEKLN 520
+L + + Q + +L +++L +L +VEEE AL+ I+ L+ + +L
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ 1117
Query: 521 EFLELERHNNNMMAKTLEECRVTLEGLKME-----------------------------N 551
E LE ER + N K + LE LK E
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLE 1177
Query: 552 GSLKSH-LQGEKQKATEASAVEQTAESCEVQEMLKV-ARAEKDLLELSCNELRQE---LL 606
K+H Q ++ + + AVE+ AE E + +K K LE EL E LL
Sbjct: 1178 EEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL 1237
Query: 607 KANGEIKH----VSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKA---SESDAEIK 659
+ G+ +H V + L +++ ++ + + A+++++ ++L S+SD++
Sbjct: 1238 QGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSS 1297
Query: 660 DMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLK-------TLTK 712
+ + LE Q++ + + N+ L + + ++E++K+ QL+ L K
Sbjct: 1298 KLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357
Query: 713 Q---MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEE-------EEKNAR 762
Q + + + ++ D + A ++K + Q++L + ++ E+ E+ R
Sbjct: 1358 QIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTR 1417
Query: 763 LQKELGDV 770
LQ+EL D+
Sbjct: 1418 LQQELDDL 1425
Score = 88.2 bits (217), Expect = 3e-17
Identities = 137/702 (19%), Positives = 294/702 (41%), Gaps = 83/702 (11%)
Query: 144 TKHLRTPSTKPKQ--ENEGGEKAALESQVRELL-----AEAKAK--DSEINRLRSELKKY 194
TK ++ K KQ ENE GE L ++V+ LL +E K K ++++ L+ + +
Sbjct: 1208 TKRVKANLEKAKQTLENERGE---LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEG 1264
Query: 195 KEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSD----LEEENRV- 249
+ RT A+ L +D + ++ L + + +L D L+EENR
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324
Query: 250 --LKEKLIYLEHSPNS-------EGAASHTGDSSCPTSITQESSFGSPTGNQMS--SDID 298
L KL +E NS E A H + T Q + + + +
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE 1384
Query: 299 EYK----KNIHGNALR----TSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPF 350
E K K++ G + R + + TK L + D + + + S+ +
Sbjct: 1385 EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD---LLVDLDHQRQSACNLEK 1441
Query: 351 KSSKCSTAGSSPNSVSELSLASLTE---KIQKMEENHHSTAEELQATLQELSDQQQMVQE 407
K K + ++S + ++ E S A L+ +++ ++ +++ ++
Sbjct: 1442 KQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQ 1501
Query: 408 LTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKI---- 463
E E L+ K + S H+ + L Q+ E++ L+E +++E T++ K+
Sbjct: 1502 FRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEE-LEDELQATEDAKLRLEV 1560
Query: 464 ------IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENE 517
+ E+ G EQ ++++L+ +++ L ++ A+ K+L+ + +
Sbjct: 1561 NLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLK 1620
Query: 518 KLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQG--EKQKATEASAVEQTA 575
L ++ N + K L + + ++ E ++ + + K E A
Sbjct: 1621 DLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEA 1680
Query: 576 ESCEVQEMLKVARAEKDLLELSCNELRQELLKANG-------EIKHVSSLLAKVEKDYSY 628
E ++QE L A K + +EL E+ ++G E + + + +A++E++
Sbjct: 1681 EMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEE 1740
Query: 629 LKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLI-- 686
+ + ++L + +L++ + ++ + E ++ + Q++ +K+ ++
Sbjct: 1741 EQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGT 1800
Query: 687 --SELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQ 744
S+ ++S+ LE + + LE QL TK+ + ++ RR + L+ ++ +D + A+Q
Sbjct: 1801 VKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQ 1860
Query: 745 ----------ELRTVKRKLLEEEEKNAR-------LQKELGD 769
L+ +KR+L E EE+ R LQ+EL D
Sbjct: 1861 YKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELED 1902
Score = 86.3 bits (212), Expect = 1e-16
Identities = 97/437 (22%), Positives = 190/437 (43%), Gaps = 70/437 (16%)
Query: 389 EELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQ 448
E+LQA + ++ +++ LTA+ ++L + LE + ER + L E +K+ +Q
Sbjct: 887 EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946
Query: 449 ---ERVKNE---------EPTTQEGKIIELEQKCTGILEQG-RFEREKLLNIQQQLTCSL 495
E+++ E E T E K+ +LE++ + +Q + +EK L + +
Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006
Query: 496 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEG--------- 546
EEE + + + +LK ++E + LE + LE+ R LEG
Sbjct: 1007 NLTEEEEKS--KSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQI 1064
Query: 547 ---------LKMENGSLKSHLQGEKQKATEASAVEQTA---------ESCEVQEMLKVAR 588
LKM+ + LQ + E +A + A + E+QE L+ R
Sbjct: 1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124
Query: 589 AEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQ 648
A ++ E +L +EL E++ A + E+ + ++++ L+
Sbjct: 1125 ASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQ-------ELRSKREQEVNILKKTLE 1177
Query: 649 EKASESDAEIKDMK----ETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLE 704
E+A +A+I++M+ + + EL +Q+EQ + VK + LE + LE ++ +L
Sbjct: 1178 EEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVK-------ANLEKAKQTLENERGELA 1230
Query: 705 RQLKTLTKQMKEETEEWRRFQADLQTAVVVAN----------DIKCEAQQELRTVKRKLL 754
++K L + + + ++ +A LQ V N D + Q EL V L
Sbjct: 1231 NEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLS 1290
Query: 755 EEEEKNARLQKELGDVQ 771
+ + K+++L K+ ++
Sbjct: 1291 QSDSKSSKLTKDFSALE 1307
Score = 80.5 bits (197), Expect = 6e-15
Identities = 146/702 (20%), Positives = 285/702 (40%), Gaps = 108/702 (15%)
Query: 155 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSE---LKKYKEKRTLN---AEGTDAL 208
+++ E E A + Q+ ++ EAK K E ++ E K KEK+ L AE T L
Sbjct: 949 EEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNL 1008
Query: 209 GPNVDGT---SVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKE------------- 252
+ + + E MI LEE+ + +K+ +LE+ R L+
Sbjct: 1009 TEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQ 1068
Query: 253 ------KLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHG 306
K+ + + A + + + ++ + ++ S I E ++++
Sbjct: 1069 AQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKI------RELESQISELQEDLES 1122
Query: 307 NALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVS 366
+ + ++ K L + E + E S+ + SK +
Sbjct: 1123 ER---ASRNKAEKQKRDLG---EELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTL 1176
Query: 367 ELSLASLTEKIQKMEENHHSTAEELQATLQEL----SDQQQMVQELTAENEKLVDEKTIL 422
E + +IQ+M + H EEL L++ ++ ++ Q L E +L +E +L
Sbjct: 1177 EEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVL 1236
Query: 423 ----ETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGR 478
S H+ ++ QL + K ERV+ E +EL+ TG+L Q
Sbjct: 1237 LQGKGDSEHKRKKVEAQLQELQVKFNE--GERVRTELADKVTKLQVELDN-VTGLLSQSD 1293
Query: 479 FEREKLLN----IQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLEL----ERHNN 530
+ KL ++ QL + ++EEN+ L + +LK+ ++ N F E E +
Sbjct: 1294 SKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKH 1353
Query: 531 NM-------------MAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAES 577
N+ M K +E+ LE + L+ L+G Q+ E A E
Sbjct: 1354 NLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413
Query: 578 CEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAK---VEKDYSYLKEICD 634
+ + + E D L + + RQ + K LLA+ + Y+ ++ +
Sbjct: 1414 TKTR-----LQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAE 1468
Query: 635 HQAEQLSRTSLKLQ---EKASESDAEIKDM-KETIFELEDQVEQHRAVKLHNNQLISELE 690
+A + +L L E+A E AE++ + K+ E+ED + V + + ELE
Sbjct: 1469 AEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDV----GKSVHELE 1524
Query: 691 SSVIKLEEQKSDLERQLKTLTKQMKEETEEWR------------RFQADLQTAVVVANDI 738
S LE+Q +++ QL+ L ++ + TE+ + +F+ DLQ + +
Sbjct: 1525 KSKRALEQQVEEMKTQLEELEDEL-QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEK 1583
Query: 739 KCEAQQELRTVKRKLLEEEEKNA-------RLQKELGDVQGH 773
K + +++R ++ +L +E ++ + +L+ +L D++ H
Sbjct: 1584 KKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAH 1625
Score = 58.2 bits (139), Expect = 3e-08
Identities = 79/326 (24%), Positives = 145/326 (44%), Gaps = 41/326 (12%)
Query: 466 LEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLEL 525
L++ C L+ ++ +L + L R+ EE E++K +++ N E+
Sbjct: 812 LQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEM 871
Query: 526 ERHNNNMMAKTL---EECRVTLEGLKMENGSLKSHLQGEKQKATE-----ASAVEQTAES 577
E + +MA+ L E+ + E L E L++ L +KQ+ E + VE+ E
Sbjct: 872 ETLQSQLMAEKLQLQEQLQAETE-LCAEAEELRARLTAKKQELEEICHDLEARVEEEEER 930
Query: 578 C---------------EVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKV 622
C E++E L+ + + L+L +L K E + K+
Sbjct: 931 CQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKL 990
Query: 623 EKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKET-IFELEDQVEQHRAVKLH 681
K+ L+ D AE T+L +E+ S+S A++K+ E I +LE+++ + +
Sbjct: 991 AKEKKLLE---DRIAE--FTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQR-- 1043
Query: 682 NNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCE 741
ELE + KLE +DL Q+ L Q+ E + + + +LQ A+ + E
Sbjct: 1044 -----QELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEE---E 1095
Query: 742 AQQELRTVKRKLLEEEEKNARLQKEL 767
A Q+ +K K+ E E + + LQ++L
Sbjct: 1096 AAQKNMALK-KIRELESQISELQEDL 1120
Score = 53.9 bits (128), Expect = 6e-07
Identities = 67/328 (20%), Positives = 136/328 (41%), Gaps = 27/328 (8%)
Query: 367 ELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSF 426
E+ L L I +N ++L+ ++ D + + + A E+++
Sbjct: 1616 EMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILA--------- 1666
Query: 427 HQHRERAEQLSQENEKLMNLLQERVKNEEPTTQ-EGKIIELEQKCTGILEQGRFEREKLL 485
Q +E ++L +++ L +E E Q + + EL + +G E+
Sbjct: 1667 -QAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKR 1725
Query: 486 NIQQQLTCSLRKVEEENQGALEMIK-RLKEEN---EKLNEFLELERHNNNMMAKTLEECR 541
++ ++ L + EE QG E+I RLK+ N +++N L LER + A+ E R
Sbjct: 1726 RLEARIA-QLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSH----AQKNENAR 1780
Query: 542 VTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNEL 601
LE E ++G + +AS A+ +++E L E+ + +C ++
Sbjct: 1781 QQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKER---QAACKQV 1837
Query: 602 RQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDM 661
R + ++K V + ++ K+ D + +L + +L+E E+
Sbjct: 1838 R----RTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASR 1893
Query: 662 KETIFELEDQVEQHRAVKLHNNQLISEL 689
++ ELED E A+ + L ++L
Sbjct: 1894 RKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 51.2 bits (121), Expect = 4e-06
Identities = 102/491 (20%), Positives = 190/491 (38%), Gaps = 101/491 (20%)
Query: 148 RTPSTKPKQENEGGEKAALESQVREL-----LAEAKAKDSEINRLRSELKKYKEKRTLNA 202
+T S K +E + E A E + + L L EA + +E+ RL + + E
Sbjct: 1454 KTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMED----- 1508
Query: 203 EGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN 262
L + D S + E RALE++ + + +L +LE+E + ++ + LE +
Sbjct: 1509 -----LMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQ 1563
Query: 263 SEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKA 322
+ A ++ +M +++++ +K S + +
Sbjct: 1564 AMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ----------RSMAVAARK 1613
Query: 323 SLSPDASDFE-HITAETPSRP-----LSSTSNPFKSSKCSTAGSSPNSVSELSLASLTE- 375
L D D E HI + +R L K C + E LA E
Sbjct: 1614 KLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD--CMRELDDTRASREEILAQAKEN 1671
Query: 376 --KIQKMEENHHSTAEELQATLQ----------ELSDQ---------------------- 401
K++ ME EEL A + EL+D+
Sbjct: 1672 EKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARI 1731
Query: 402 QQMVQELTAE--NEKLVDEKTI--------------LETSFHQHRERA-EQLSQENEKLM 444
Q+ +EL E N +L++++ LE S Q E A +QL ++N++L
Sbjct: 1732 AQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELK 1791
Query: 445 NLLQER---VKNEEP---TTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKV 498
LQE VK++ T E KI +LE++ ++ + +++ +++L L +V
Sbjct: 1792 VKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQV 1851
Query: 499 EEENQGALEM----------IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLK 548
++E + A + +K+LK + E+ E + + + + LE+ T + +
Sbjct: 1852 DDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMN 1911
Query: 549 MENGSLKSHLQ 559
E SLK+ L+
Sbjct: 1912 REVSSLKNKLR 1922
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 88.2 bits (217), Expect = 3e-17
Identities = 103/455 (22%), Positives = 199/455 (43%), Gaps = 37/455 (8%)
Query: 336 AETPSRPLSSTSNPFKSSKCSTAG-----SSPNSVSELSLASLTEKIQKMEENHHSTAEE 390
AE LSS+ N K+ S+ N L L +++ ++EE + S
Sbjct: 573 AEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSR 632
Query: 391 LQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLS-------QENEKL 443
++A Q + Q + E E L ++ T LE + E +L +E E++
Sbjct: 633 MEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI 692
Query: 444 MNLLQE-RVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEEN 502
L E R + E TTQ ++ + ++ +L + E+E L+ + L L+ VE +
Sbjct: 693 QKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDR 752
Query: 503 QGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEK 562
Q E ++ L E L L + N+++ T + V ++ + ++ ++ K
Sbjct: 753 QDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLK 812
Query: 563 -QKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAK 621
+ TE S EQ ++ Q +A+AE++ + E KA E K V+ L K
Sbjct: 813 LELDTERSQAEQERDAAARQ----LAQAEQE------GKTALEQQKAAHE-KEVNQLREK 861
Query: 622 VEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRA-VKL 680
EK+ S+ ++ E L R ++L+ + E E++ ++ E Q E ++L
Sbjct: 862 WEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQL 921
Query: 681 HNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKC 740
+ L ++++ +++ +D +QL+ L + MK + + + LQT +
Sbjct: 922 ETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQ------- 974
Query: 741 EAQQELRTVKRK----LLEEEEKNARLQKELGDVQ 771
EAQ+EL+ R+ L +E+++ L ++ D+Q
Sbjct: 975 EAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQ 1009
Score = 82.0 bits (201), Expect = 2e-15
Identities = 99/446 (22%), Positives = 191/446 (42%), Gaps = 55/446 (12%)
Query: 365 VSELSLASLTEKIQKMEENHHSTAEELQATL----QELSDQQQMVQELTAENEKLVDEKT 420
V + L E+ + E++ S +E Q L QEL QQ Q+ + E++ ++
Sbjct: 1782 VLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKAD 1841
Query: 421 ILETSFHQH----RERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQ 476
L+ + Q +ER +L E+ L EE EG+ ++ ++ G L
Sbjct: 1842 ALQGALEQAHMTLKERHGELQDHKEQARRL-------EEELAVEGRRVQALEEVLGDLRA 1894
Query: 477 GRFEREK-LLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAK 535
E+EK LL +QQQ ++ E E + + + + ++ ++ LE R +
Sbjct: 1895 ESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRH 1954
Query: 536 TLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT--AESCEVQEMLKVARAE--- 590
E R E L+ G + LQG++Q E + + ++ A + +Q L +A
Sbjct: 1955 QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQ 2014
Query: 591 -KDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSL---- 645
++ L + E++ + L+ +++ + LA+ +++ + +E EQL SL
Sbjct: 2015 LEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQE-----REQLLEKSLAQRV 2069
Query: 646 ---KLQEKAS----ESDAEIKDMKETIFEL-------EDQVEQHRAVKLHNN-------Q 684
+QEK + + EI+ + +++ EL E ++ + R + NN
Sbjct: 2070 QENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSH 2129
Query: 685 LISELESSVIKLEEQKSDLERQLKTL---TKQMKEETEEWRRFQADLQTAVVVANDIKCE 741
S +E +KL+ + L+R+L+ L +Q + EWR DL ++
Sbjct: 2130 KTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSS 2189
Query: 742 AQQELRTVKRKLLEEEEKNARLQKEL 767
Q+ ++ +LE + + RLQ EL
Sbjct: 2190 LQEVAMFLQASVLERDSEQQRLQDEL 2215
Score = 73.6 bits (179), Expect = 7e-13
Identities = 140/683 (20%), Positives = 265/683 (38%), Gaps = 104/683 (15%)
Query: 150 PSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALG 209
PS + ++ G ++ + A+A S +++L +L K ++ R D L
Sbjct: 1211 PSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTR-------DVLR 1263
Query: 210 PNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASH 269
V DTE + + ++ Q++LS +EE K K ++S SE H
Sbjct: 1264 DQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEE----KSKWEGKQNSLESELMELH 1319
Query: 270 TGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 329
+S + + + R ++ +A+ +
Sbjct: 1320 ETMASLQSRLRR------------------------AELQRMEAQGERELLQAAKENLTA 1355
Query: 330 DFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAE 389
EH+ A +++ TA S+ +E + S E+ Q ++E
Sbjct: 1356 QVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE-EVESERERAQALQEQGELKVA 1414
Query: 390 ELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQE 449
+ +A + L+ Q + E E E L + LE + E LS + +K
Sbjct: 1415 QGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKK------- 1467
Query: 450 RVKNEEPTTQEGKIIELEQKCTGILEQGRF---EREKLLNIQQQLTCSLRKVEEENQGAL 506
+N+E Q+ +I ELE KC +LE ERE+ L +Q++ +R++E++ +
Sbjct: 1468 --RNQEVDLQQEQIQELE-KCRSVLEHLPMAVQEREQKLTVQRE---QIRELEKDRETQR 1521
Query: 507 EMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLE--GLKMENGSLKSHLQG---- 560
+++ E EK ++ +E +R + K L VTLE L++E K Q
Sbjct: 1522 NVLEHQLLELEKKDQMIESQRGQVQDLKKQL----VTLECLALELEENHHKMECQQKLIK 1577
Query: 561 --EKQKATEASAVEQ-TAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSS 617
E Q+ T+ A+ T + E + L+ ++ LE L +EL + + E+K
Sbjct: 1578 ELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE 1637
Query: 618 LLAKVEKDYSYLKEICDHQ-------------------------AEQLSRTSLKLQEKAS 652
+ ++++ +L + + + E L + L L+E+
Sbjct: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGR 1697
Query: 653 ESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI-------KLEEQKSDLER 705
E + + M+E E + + R H ++ + E V +L+E K LE+
Sbjct: 1698 ELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQ 1757
Query: 706 QLKTLTKQMKEET-------EEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEE 758
QL+ L +++ E + +E Q LQ A + Q +L +R L + ++
Sbjct: 1758 QLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ 1817
Query: 759 KNARLQKELGDVQGHGRVVTSRA 781
+ LQ+E QG V +A
Sbjct: 1818 ELEALQQEQQQAQGQEERVKEKA 1840
Score = 73.2 bits (178), Expect = 9e-13
Identities = 97/406 (23%), Positives = 181/406 (44%), Gaps = 61/406 (15%)
Query: 370 LASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQH 429
L + + +I +E + A ELQ QE+ Q++ ++EL + E L
Sbjct: 1604 LQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHL-------------- 1649
Query: 430 RERAEQLSQENEKLMNLLQERVK-NEEPTTQEGKIIE--LEQKCTGILEQGRFEREKLLN 486
+ L + +++LM L +ER++ E+ T++ KI+E LEQ + E+GR E
Sbjct: 1650 ---TQDLERRDQELM-LQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGR-ELTTQRQ 1704
Query: 487 IQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEG 546
+ Q+ + + +G+LE +K + + EK E + H L+
Sbjct: 1705 LMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHE--------------LQE 1750
Query: 547 LKMENGSLKSHLQGEKQKATEASAV--EQTAESCEVQEMLKVARAEKDLLELS----CNE 600
LK L+ LQG +K E S + ++ E +Q+ L+ AR + +L E S +E
Sbjct: 1751 LK---DQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDE 1807
Query: 601 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKD 660
++ L + + E++ + + + +KE D L + + L+E+ E++D
Sbjct: 1808 AQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKER----HGELQD 1863
Query: 661 MKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEE 720
KE LE+++ AV+ + + LE + L + + E+ L L +Q E+ +E
Sbjct: 1864 HKEQARRLEEEL----AVE---GRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQE 1916
Query: 721 WRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKE 766
LQ + + A + E QEL + L E +++R Q+E
Sbjct: 1917 HEVETRALQDSWLQAQAVLKERDQEL-----EALRAESQSSRHQEE 1957
Score = 63.9 bits (154), Expect = 5e-10
Identities = 103/459 (22%), Positives = 198/459 (43%), Gaps = 60/459 (13%)
Query: 373 LTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRER 432
L E ++ ++ + EE + LQ+ D Q+ V++L ++ D + ++E +E
Sbjct: 980 LKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVE------QEV 1033
Query: 433 AEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLT 492
E+L + E N +Q+ ++ E+ + ++E EQ+ + E +++L ++Q +
Sbjct: 1034 QEKLRETQE--YNRIQKELEREKASLTLS-LMEKEQRLLVLQEADSIRQQELSALRQDMQ 1090
Query: 493 CSLRKVEEENQGALEMIKRLKEENE--------KLNEFLELERHNNNMMAKTLEECRVTL 544
+ ++E +E++++ +E E +L E LE + +L
Sbjct: 1091 -EAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKA 1149
Query: 545 EGLKMENGSLKSHLQG---EKQKATEASAVEQTAE--SCEVQEMLKVARAEKDL------ 593
L++ S +S L+ E+Q +A A Q A S Q + V + +L
Sbjct: 1150 AQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDS 1209
Query: 594 ------LELSCNELRQ-----ELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSR 642
LE N R LL A + V+S L K+ +D ++ D +Q+
Sbjct: 1210 APSVWGLEPDQNGARSLFKRGPLLTALSA-EAVASALHKLHQDLWKTQQTRDVLRDQVQ- 1267
Query: 643 TSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSD 702
KL+E+ ++++AE + + +L+ Q+ Q++ K + LES +++L E +
Sbjct: 1268 ---KLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMAS 1324
Query: 703 LERQLKTLTKQMKEETEEWRRFQA----------DLQTAVVVANDIKCEA---QQELRTV 749
L+ +L+ Q E E QA LQ AVV A A +++LRT
Sbjct: 1325 LQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTA 1384
Query: 750 KR--KLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPSL 786
+ KL EE ++ R + + QG +V +A +L
Sbjct: 1385 RSALKLKNEEVESERERAQALQEQGELKVAQGKALQENL 1423
Score = 63.2 bits (152), Expect = 9e-10
Identities = 88/393 (22%), Positives = 170/393 (43%), Gaps = 48/393 (12%)
Query: 367 ELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSF 426
EL L + + QK E+ EEL ++E Q+M+ L A+ + + E L +
Sbjct: 495 ELQLQGDSAQGQKEEQQ-----EELHLAVRERERLQEMLMGLEAKQSESLSELITLREAL 549
Query: 427 HQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLN 486
E L QE ++ L ++ + ++ E + R KL
Sbjct: 550 ESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTE------VADLRAAAVKLSA 603
Query: 487 IQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEG 546
+ + L +L KV G + + +L+EEN+ + +E N + L E E
Sbjct: 604 LNEAL--ALDKV-----GLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREA 656
Query: 547 LKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELL 606
L +N +HL+ + QKA EA A E+Q L+ + EK+ ++ +E R +
Sbjct: 657 LWEKN----THLEAQLQKAEEAGA--------ELQADLRDIQEEKEEIQKKLSESRHQQE 704
Query: 607 KANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIF 666
A +++ + + E+ + + + + +A + +L+++ +A E D + D+ E +
Sbjct: 705 AATTQLEQLHQEAKRQEEVLA--RAVQEKEALVREKAALEVRLQAVERDRQ--DLAEQLQ 760
Query: 667 ELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQA 726
L E L ++ ++ ++SVI E K LE Q++T+T+ + E R +
Sbjct: 761 GLSSAKE-----LLESSLFEAQQQNSVI--EVTKGQLEVQIQTVTQAKEVIQGEVRCLKL 813
Query: 727 DLQTAVVVANDIKCEAQQELRTVKRKLLEEEEK 759
+L T + +A+QE R+L + E++
Sbjct: 814 ELDTE-------RSQAEQERDAAARQLAQAEQE 839
Score = 48.9 bits (115), Expect = 2e-05
Identities = 102/456 (22%), Positives = 193/456 (42%), Gaps = 85/456 (18%)
Query: 389 EELQATLQE--LSDQQQMVQELTAENEKLVDEKTI----------LETSFHQHRERAEQL 436
+ LQ L+E L+ QQQM + A KL + + L+ Q+R ++L
Sbjct: 14 QSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQEL 73
Query: 437 SQENEKLMNLLQERVKN-EEPTTQE--GKIIELEQKCTGILE---QGRFEREKLLNIQQQ 490
+ E + +R +N EEP E ++ E +Q+C + E Q R EK + +
Sbjct: 74 EKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA 133
Query: 491 LTCSLRKVEEENQGALEMIKR---------------LKEENEKL----NEFLELERHNNN 531
L + K+ + A + + R LK E+ +L E + RH
Sbjct: 134 LREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLE 193
Query: 532 MMAKTLEEC-RVTLEGLKMENGSLKSHLQ---GEKQKATEASAVEQTAESCEVQEMLKVA 587
M + T + + E +++ L L+ G + + S E ++ +L +A
Sbjct: 194 MKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQL--LLLLA 251
Query: 588 RAEKDLLELSCNELRQEL--LKANGEIK---------HVSSLLAKVEK---DYSYL---- 629
+ ++ LE +E QEL LK+ G+++ +S+LL + +K DY +
Sbjct: 252 KTQE--LEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKAL 309
Query: 630 -----------KEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAV 678
E+ +H+A LSR + QE+ IKD+ + + E D + Q
Sbjct: 310 RETVEILETNHTELMEHEAS-LSRNA---QEEKLSLQQVIKDITQVMVEEGDNIAQGSG- 364
Query: 679 KLHNNQLISELESSVI-KLEEQKSDLERQL-KTLTKQMKEETEEWRRFQADLQTAVVVAN 736
H N L EL+SS+ + + Q +D L +++ + ++ ++ R+ A Q AV +
Sbjct: 365 --HENSL--ELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQ 420
Query: 737 DIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQG 772
+ ++E + ++++L + + L + D+QG
Sbjct: 421 QQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQG 456
Score = 48.9 bits (115), Expect = 2e-05
Identities = 133/610 (21%), Positives = 243/610 (39%), Gaps = 83/610 (13%)
Query: 155 KQENEGGE--KAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNV 212
++ E GE + +L+SQ+ E +D E+ L+ E ++ + + E DAL +
Sbjct: 1788 QEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGAL 1847
Query: 213 DGTSVSPGDTEPMIRALEEKNKNFQKELS--------------DLEEENRVLKEKLIYLE 258
+ ++ + ++ +E+ + ++EL+ DL E+R ++ L+ L+
Sbjct: 1848 EQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQ 1907
Query: 259 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSD 318
+ A + T Q+S Q + + E + + ALR SS
Sbjct: 1908 -----QQCAEQAQEHEVETRALQDSWL------QAQAVLKERDQEL--EALRAESQSSRH 1954
Query: 319 VTKASLS-----PDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASL 373
+A+ + +A H + + L + +S + STA + SL +
Sbjct: 1955 QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTA------TLQASLDAC 2008
Query: 374 TEKIQKMEENHHSTAEELQ-ATLQELSDQQQMVQELTAENEKL---VDEKTILETSFHQH 429
+++EE E+Q L+ D QQ+ Q L +E+L + + +LE S Q
Sbjct: 2009 QAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQR 2068
Query: 430 RERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELE----QKCTGILE----QGRFER 481
+ E + QE + NL QER + EE + EL+ QK ILE Q R
Sbjct: 2069 VQ--ENMIQEKQ---NLGQER-EEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNL 2122
Query: 482 EKLLNIQQ------------QLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHN 529
E L + + L L++ E Q AL + + E + + L L
Sbjct: 2123 EALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQ 2182
Query: 530 NNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARA 589
+L+E + L+ +E S + LQ E + A E+ +R
Sbjct: 2183 TKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRG 2242
Query: 590 EK--DLLELSCNELR-----QELLKANGEIKHVSSLLAKVEKDYSYLKE---ICDHQAEQ 639
E+ L E+S E E ++H+ +A++E D S L+ EQ
Sbjct: 2243 EQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQ 2302
Query: 640 LSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQH-RAVKLHNNQLISELESSVIKLEE 698
+ R KL+ +A + A+ ++ + +Q R K + + ++EL+ V+ L+
Sbjct: 2303 VERERRKLKREAMRA-AQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQA 2361
Query: 699 QKSDLERQLK 708
Q + LER+ K
Sbjct: 2362 QLT-LERKQK 2370
Score = 48.5 bits (114), Expect = 2e-05
Identities = 95/441 (21%), Positives = 167/441 (37%), Gaps = 58/441 (13%)
Query: 368 LSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFH 427
LSL +++ ++E +EL A Q++ + Q +EL+A+ E L E E F
Sbjct: 1059 LSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADF- 1117
Query: 428 QHRERAEQLSQENEKLMNLLQERVKNEEPT----TQEGKIIELE---------------Q 468
L+QE + L L + ++ QE K +L+ +
Sbjct: 1118 --------LAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAE 1169
Query: 469 KCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRL----KEENEKLNEFLE 524
+ G Q + + L + QQ S+ + E G + + ++N + F
Sbjct: 1170 QQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKR 1229
Query: 525 ---LERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQ--GEKQKATEASAVEQTAESCE 579
L + +A L + L + L+ +Q E+ TEA + E +
Sbjct: 1230 GPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQD 1289
Query: 580 VQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVE---KDYSYLKEICDHQ 636
+Q L + EK E N L EL++ + + + S L + E + +E+
Sbjct: 1290 LQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAA 1349
Query: 637 AEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKL 696
E L+ LQ E+ A+ I E ED A+KL N ++ SE E +
Sbjct: 1350 KENLTAQVEHLQAAVVEARAQAS--AAGILE-EDLRTARSALKLKNEEVESERERAQALQ 1406
Query: 697 EE------QKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVK 750
E+ Q L+ L LT+ + E EE + +Q + E Q+E++
Sbjct: 1407 EQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQ---------ELEKQREMQKAA 1457
Query: 751 RKLLEEEEKNARLQKELGDVQ 771
+LL + K + +L Q
Sbjct: 1458 LELLSLDLKKRNQEVDLQQEQ 1478
Score = 44.3 bits (103), Expect = 4e-04
Identities = 76/347 (21%), Positives = 139/347 (40%), Gaps = 71/347 (20%)
Query: 465 ELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKL-NEFL 523
E Q+ + QG E+ +L + +L+ L + +++N+ +MIK L+E E L
Sbjct: 262 ERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHT 321
Query: 524 ELERHNNNMMAKTLEECRVTL-------------EGLKMENGS-------LKSHL--QGE 561
EL H ++ EE +++L EG + GS L S + Q +
Sbjct: 322 ELMEHEASLSRNAQEE-KLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFD 380
Query: 562 KQKATEASAVEQTA-------------ESCEVQEMLKVARAEKDLLELSCNELRQELLKA 608
Q A +A + ++ + QE + + + + D E LRQ L K
Sbjct: 381 YQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKL 440
Query: 609 NGE-----------------IKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKA 651
GE + LL K ++ E+ + +A +L R +++LQ +
Sbjct: 441 TGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQG 500
Query: 652 SESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLT 711
+ + KE E Q E H AV+ L+ ++ LE ++S+ +L TL
Sbjct: 501 DSAQGQ----KE-----EQQEELHLAVRER-----ERLQEMLMGLEAKQSESLSELITLR 546
Query: 712 KQMKE---ETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLE 755
+ ++ E E R+ Q ++ A+ A E T+K ++ +
Sbjct: 547 EALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVAD 593
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 87.8 bits (216), Expect = 4e-17
Identities = 142/747 (19%), Positives = 301/747 (40%), Gaps = 138/747 (18%)
Query: 155 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKY---------------KEKRT 199
KQ+N+ + LE++ LL++ KD E+ L+ E+ K K K T
Sbjct: 1856 KQKNKEFSQT-LENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKET 1914
Query: 200 LNAEGTDA----------LGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEE-NR 248
E D L ++ D + LE + KN +K +S+LEEE +
Sbjct: 1915 AEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQ 1974
Query: 249 VLKEKL-----IYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKN 303
++KEK I E+ +GA G+ S + + Q+ D Y++
Sbjct: 1975 LVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEK 2034
Query: 304 IHG--------NALRTSGSSSSDVTKASLS----------PDASDFEHITAETPSRPLSS 345
I ++T ++TK +L+ + + F+ + +T S
Sbjct: 2035 ISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARV 2094
Query: 346 TSNPFKSSK-CSTAGSSPNSVSELSLASLTEKIQKMEENH-------------------- 384
++ K K + S S + L ++++ EE H
Sbjct: 2095 LADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVH 2154
Query: 385 -HSTAEELQATLQELSDQQQMVQE------------------LTAENEKLVDEKTILETS 425
T E+Q TL + + Q +QE L + ++++DE E
Sbjct: 2155 LEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERK 2214
Query: 426 FHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLL 485
F + E+ + E ++L+++++ +E KI + + + + + E +
Sbjct: 2215 FSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTE--V 2272
Query: 486 NIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNM------MAKTLEE 539
+QQ++ +L+ +E LE + L ++ NE +LE ++ ++ +LE+
Sbjct: 2273 QLQQKVCDTLQGENKELLSQLEETRHLYHSSQ--NELAKLESELKSLKDQLTDLSNSLEK 2330
Query: 540 CRV---TLEG-LKMENGSLKSHLQGEKQKATEASAVEQTAE------SCEVQEMLKVARA 589
C+ LEG ++ + +++ +Q T+ A + + + Q+++ +
Sbjct: 2331 CKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSG 2390
Query: 590 EKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKE---ICDHQAEQLSRTSLK 646
+++ ++++ ELRQ+ K EIK + +LL++ E++ L+E + QL T
Sbjct: 2391 KEEAIQVAIAELRQQHDK---EIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKT 2447
Query: 647 LQEKASESDAEIKDMKETIFELEDQ-----------VEQHRAVKLHNNQLISELESSVIK 695
++++ + A++ +++ L++ E+H ++ L +QLI E + K
Sbjct: 2448 IKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNK 2507
Query: 696 LEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVAN-------DIKCEAQQELRT 748
L+E+ L + L + + E +++ DL + + + +++ + +EL
Sbjct: 2508 LKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELEN 2567
Query: 749 ----VKRKLLEEEEKNARLQKELGDVQ 771
++ KL E EE N L++ +Q
Sbjct: 2568 KYAKLEEKLKESEEANEDLRRSFNALQ 2594
Score = 79.0 bits (193), Expect = 2e-14
Identities = 140/675 (20%), Positives = 267/675 (39%), Gaps = 122/675 (18%)
Query: 162 EKAALESQVRELLAEAKA----KDSEINRLRSELKK----YKEKRTLNAEGTDA------ 207
EK A E Q + L+ + K ++I+ L++E+ + ++ T N + +D
Sbjct: 1082 EKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALV 1141
Query: 208 -----LGPNVDGTSVS-PGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSP 261
+ P G+S + E I ALE++ + QK+L + + + +K E
Sbjct: 1142 KETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHL 1201
Query: 262 NSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTK 321
E + ++S G+Q+ + +++I G T S T
Sbjct: 1202 REELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTP 1261
Query: 322 ASLSP--DASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSEL----SLASLTE 375
P A++ H T +S+ C S S L S+A +
Sbjct: 1262 GLEEPLFKATEQHH------------TQPVLESNLCPDWPSHSEDASALQGGTSVAQIKA 1309
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 435
+++++E ++ +T EL+ + + V +L + K E L+T H+ AE
Sbjct: 1310 QLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAES 1369
Query: 436 LSQ--ENEKLMNLLQERVKNEEPTTQE-GKIIELEQKCTGILEQGRFEREKLLNIQQQLT 492
L Q E+ +L E ++ +P E K+I +++ L E+E
Sbjct: 1370 LQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKE---------- 1419
Query: 493 CSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKM-EN 551
+L K++ E ++IK L + E ++ + H+ + +E C + + ++ E
Sbjct: 1420 AALTKIQTEIIEQEDLIKALHTQLE-----MQAKEHDERIKQLQVELCEMKQKPEEIGEE 1474
Query: 552 GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 611
K +Q K +A S E E+ +QE L +AR + L S ++ ++ N E
Sbjct: 1475 SRAKQQIQ-RKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKE 1533
Query: 612 IKHVSSLLAKVEKDYSYL-----KEICDHQAEQLSRTSLKL------------------- 647
V LA ++++ L + + ++Q+ S SLKL
Sbjct: 1534 KDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL 1593
Query: 648 -----------QEKASESDAEIKDMKETIFELEDQVE--QH--RAVKLHNNQLISELESS 692
QEK E E + + ++ + ++ E QH AV+ +L +L S+
Sbjct: 1594 KSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRST 1653
Query: 693 VIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRK 752
E K + E+QL+ ++M+E E+ R+F ++ ++K
Sbjct: 1654 ----EANKKETEKQLQEAEQEMEEMKEKMRKF---------------------AKSKQQK 1688
Query: 753 LLEEEEKNARLQKEL 767
+LE EE+N RL+ E+
Sbjct: 1689 ILELEEENDRLRAEV 1703
Score = 78.6 bits (192), Expect = 2e-14
Identities = 102/434 (23%), Positives = 184/434 (42%), Gaps = 44/434 (10%)
Query: 367 ELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSF 426
+L+L LTE +K+ + S + + E ++ Q+ +EL E E L+ +
Sbjct: 1573 KLALEGLTEDKEKLVKEIESLKS---SKIAESTEWQEKHKELQKEYEILLQSYENVSNEA 1629
Query: 427 HQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGR----FERE 482
+ + E + QE ++L L+ N++ T E ++ E EQ+ + E+ R +++
Sbjct: 1630 ERIQHVVEAVRQEKQELYGKLRSTEANKKET--EKQLQEAEQEMEEMKEKMRKFAKSKQQ 1687
Query: 483 KLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRV 542
K+L ++++ +V A E ++ L N + E LE + ++K +
Sbjct: 1688 KILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMS 1747
Query: 543 TLEGLKMENGSLKSHLQGEKQKATEASAVE----QTAESCEVQEMLKVARAEKDLLELSC 598
+ L E LK ++G K A E QT + E + + E+D L +S
Sbjct: 1748 EKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMST 1807
Query: 599 NELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDH--QAEQLSRTSLKLQE---KASE 653
E + S V KD+S EI ++ Q +QL L+E K E
Sbjct: 1808 RPTCSE------SVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKE 1861
Query: 654 SDAEIKDMKETIF--------ELEDQVEQHRAVKLHNNQLISELESSVIKL----EEQKS 701
+++ K T+ EL+ E+ + L N Q+ EL S V KL EE+K
Sbjct: 1862 FSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEEL-SRVTKLKETAEEEKD 1920
Query: 702 DLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNA 761
DLE +L ++ + + D Q + N++ + E++ +K+ + E EE+
Sbjct: 1921 DLEERLMNQLAELNGSIGNYCQDVTDAQ----IKNEL---LESEMKNLKKCVSELEEEKQ 1973
Query: 762 RLQKELGDVQGHGR 775
+L KE V+ R
Sbjct: 1974 QLVKEKTKVESEIR 1987
Score = 67.8 bits (164), Expect = 4e-11
Identities = 103/463 (22%), Positives = 180/463 (38%), Gaps = 105/463 (22%)
Query: 376 KIQKMEENHHSTAEELQATLQELSD-----------QQQMVQELTAENEKLVDE------ 418
K++ E N T ++LQ QE+ + +QQ + EL EN++L E
Sbjct: 1649 KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD 1708
Query: 419 --KTILETSFHQH---RERAEQLSQENEKLMNLLQERVKNEEPTTQEGKII--------- 464
K +ET + +E E++ E E L Q + ++ ++E + +
Sbjct: 1709 TAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVS 1768
Query: 465 --------ELEQKCTGILEQG------RFEREKLLNIQQQLTCSLR-------------- 496
E T + E+G E + L++ + TCS
Sbjct: 1769 KQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKD 1828
Query: 497 -KVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLE-ECRVTLEGLKMENGSL 554
+E L+ I +LKE L E E+ N ++TLE E L + ++G L
Sbjct: 1829 FSSHDEINNYLQQIDQLKERIAGLEE----EKQKNKEFSQTLENEKNTLLSQISTKDGEL 1884
Query: 555 KSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKH 614
K LQ E K + Q E V ++ + A EKD LE L +L + NG I +
Sbjct: 1885 KM-LQEEVTKMNLLNQQIQE-ELSRVTKLKETAEEEKDDLE---ERLMNQLAELNGSIGN 1939
Query: 615 VSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQ 674
Y +++ D Q K ++E+K++K+ + ELE++ +Q
Sbjct: 1940 -------------YCQDVTDAQI------------KNELLESEMKNLKKCVSELEEEKQQ 1974
Query: 675 HRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQAD------- 727
K I + I+ +++ + K L + +KE+ +E ++ Q D
Sbjct: 1975 LVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEK 2034
Query: 728 ---LQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKEL 767
L+ V ++ E+Q++L K L + E + Q EL
Sbjct: 2035 ISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAEL 2077
Score = 64.3 bits (155), Expect = 4e-10
Identities = 134/654 (20%), Positives = 262/654 (40%), Gaps = 70/654 (10%)
Query: 162 EKAALESQ-VRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPG 220
E+A +Q +++L + + K EI++ + L + + D +GT
Sbjct: 411 EQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYN---EGTQAV-- 465
Query: 221 DTEPMIRALEEKNKNFQKE----------LSDLEEENRVLKEKLIYLEHSPNSEGAASHT 270
TE I +L+++ + E L +L+ EN L ++ LE + A
Sbjct: 466 -TEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREV 524
Query: 271 GDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLS----- 325
+ S + SS +G + + K L + ++ L
Sbjct: 525 SEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKR 584
Query: 326 PDASDFEHITAETPSRPLSSTSNPFKSSKC--STAGSSPNSVSELSLASLTEKIQKMEEN 383
+ +D E + + + P K T P +E S EK Q E+
Sbjct: 585 AEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEH 644
Query: 384 HHSTAEELQ---ATLQELSDQQQMVQELTA----------ENEKLVDEKTILETSFHQHR 430
T+EE+ A ++ S +Q + L+A E E+L + LE +FH+ +
Sbjct: 645 QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQ 704
Query: 431 E----RAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLN 486
E ++ ++E L L++E KN + L ++ +L Q K L+
Sbjct: 705 EIYEKNLDEKAKEISNLNQLIEEFKKNAD--NNSSAFTALSEERDQLLSQ-----VKELS 757
Query: 487 IQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELER-HNNNMMAKTLEECRVTLE 545
+ +L ++++ E N E +RL E++ ++ L E+ H+ ++ AK+ + V +E
Sbjct: 758 MVTELRAQVKQL-EMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKD---VKIE 813
Query: 546 GLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQEL 605
L+ E ++ + + Q ES EV E + R +E EL Q L
Sbjct: 814 VLQNELDDVQLQFSEQSTLIRSLQSQLQNKES-EVLEGAERVRHISSKVE----ELSQAL 868
Query: 606 LKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESD-------AEI 658
+ EI + LL + ++D L++ + + +Q++ S + EK + + EI
Sbjct: 869 SQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEI 928
Query: 659 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 718
K +KE + L E + +N++ S L+ + ++ + +L+ +K+E
Sbjct: 929 KTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKEN 988
Query: 719 EEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARL-QKELGDVQ 771
E+ +R LQ A++ ++ + L L +E +K L + E G+V+
Sbjct: 989 EQRKR---KLQAALINRKEL-LQRVSRLEEELANLKDESKKEIPLSETERGEVE 1038
Score = 63.2 bits (152), Expect = 9e-10
Identities = 88/436 (20%), Positives = 182/436 (41%), Gaps = 47/436 (10%)
Query: 373 LTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRER 432
LTE+I + S +++ EL D Q E + L + E+ + ER
Sbjct: 794 LTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAER 853
Query: 433 AEQLSQENEKLMNLLQER----VKNEEPTTQEGKIIE-----LEQKCTGILEQGRFEREK 483
+S + E+L L ++ K ++ ++ + +E +E+K + E EK
Sbjct: 854 VRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEK 913
Query: 484 LLNIQQQ---LTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAK----T 536
++ + ++ L ++ ++E+ + KE+ E+ NE + N + M+ +
Sbjct: 914 MVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQIS 973
Query: 537 LEECRVTLEGLKMENGSLKSHLQG----EKQKATEASAVEQTAESCEVQEMLKVARAEKD 592
EE + + LK EN K LQ K+ S +E+ E+ + ++ E
Sbjct: 974 KEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEE-----ELANLKDESKKEIP 1028
Query: 593 LLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKAS 652
L E E+ ++ K V+S ++E YLK+ + +L L+EK +
Sbjct: 1029 LSETERGEVEEDKENKEYSEKCVTSKCQEIE---IYLKQTISEKEVELQHIRKDLEEKLA 1085
Query: 653 ESD---AEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKS-DLERQLK 708
+ A +K M +T+ + +Q++ +A N +I +L +S + S L ++
Sbjct: 1086 AEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETV 1145
Query: 709 TLTKQMKEETEEWR---------------RFQADLQTAVVVANDIKCEAQQELRTVKRKL 753
++ +E W+ + Q LQ A+ I +AQ++ R ++ +L
Sbjct: 1146 VISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREEL 1205
Query: 754 LEEEEKNARLQKELGD 769
++++ RLQ++ +
Sbjct: 1206 KQQKDDYNRLQEQFDE 1221
Score = 59.7 bits (143), Expect = 1e-08
Identities = 113/598 (18%), Positives = 238/598 (39%), Gaps = 75/598 (12%)
Query: 182 SEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKN----KNFQ 237
SE R+ ++ K K++ N E + D D E + EEK+ KN Q
Sbjct: 2089 SEAARVLADNLKLKKELQSNKESVKSQMKQKDE------DLERRLEQAEEKHLKEKKNMQ 2142
Query: 238 KELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDI 297
++L L E L+E + ++ + N + + +++TQ ++F + S +
Sbjct: 2143 EKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAF-----TKSMSSL 2197
Query: 298 DEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCST 357
+ + + A + S + S E I K CS
Sbjct: 2198 QDDRDRVIDEAKKWERKFSDAIQ--------SKEEEIR--------------LKEDNCSV 2235
Query: 358 AGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVD 417
+S + + L I ++E + + Q +Q QQ++ L EN++L+
Sbjct: 2236 LKDQLRQMS-IHMEELKINISRLEHDKQIWESKAQTEVQL---QQKVCDTLQGENKELLS 2291
Query: 418 EKTILETSFHQHRERAEQLSQENEKLMNLLQERVKN-EEPTTQEGKIIELEQKCTGILEQ 476
+ +H + +L E + L + L + + E+ Q+G + + ++ ++
Sbjct: 2292 QLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQN 2351
Query: 477 GRFEREKL---LNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMM 533
+F E+L L ++LT L EE N ++I L + E + + R ++
Sbjct: 2352 SKFSYEQLETDLQASRELTSRLH--EEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKE 2409
Query: 534 AKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDL 593
K LE L + EN L+ + K + +T + +Q+ +A+ D
Sbjct: 2410 IKELENL---LSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQ-----KAQLDS 2461
Query: 594 LELSCNELRQELLKANG-----EIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQ 648
S + L+ + + G E +H+S +L K D ++ + + KL+
Sbjct: 2462 FVKSMSSLQNDRDRIVGDYQQLEERHLSIILEK------------DQLIQEAAAENNKLK 2509
Query: 649 EKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLK 708
E+ + + D+ +L+ ++ Q+R NQ+I+ +S +L E + ++L+
Sbjct: 2510 EEIRGLRSHMDDLNSENAKLDAELIQYRE---DLNQVITIKDSQQKQLLEVQLQQNKELE 2566
Query: 709 TLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKE 766
+++E+ +E DL+ + + K + +E+ ++K + + + LQ+E
Sbjct: 2567 NKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEE 2624
Score = 58.5 bits (140), Expect = 2e-08
Identities = 128/609 (21%), Positives = 242/609 (39%), Gaps = 97/609 (15%)
Query: 155 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 214
K E E+ A ++++++L AKAK + +N+ E+K G
Sbjct: 78 KDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMK-------------------AQG 118
Query: 215 TSVSPGDTEPMIRA-LEEKNKNFQKELSDLEEENRVLKEK--LIYLEHSPNSEGAASHTG 271
+V P TEP L + +K+ +E ++E+ L+EK LI + ++ A
Sbjct: 119 GTVLP--TEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPA 176
Query: 272 DSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDF 331
SS T+ F M + E ++ I + S + + + + + F
Sbjct: 177 QSS-----TEMEEFV-----MMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARF 226
Query: 332 EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEEL 391
E L + + + + L L K+++ EE+ A+ +
Sbjct: 227 ETQVRLHEDELLQLVTQ-----------ADVETEMQQKLRVLQRKLEEHEESLVGRAQVV 275
Query: 392 QATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENE--------KL 443
QEL+ +Q Q L+ + +++ E L + RE ++ L ++ E
Sbjct: 276 DLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSF 335
Query: 444 MNLLQERVKNEEPTTQEGKI-IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEEN 502
NL +E E Q G+ ELE + + + ++ + E E+ + SL+K +E
Sbjct: 336 HNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEE----KTSHILSLQKTGQEL 391
Query: 503 QGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEK 562
Q A + LK++N KL L+ + A+T+++ L+ E + L ++
Sbjct: 392 QSACDA---LKDQNSKL---LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQ 445
Query: 563 QK-ATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAK 621
+ A++ S + E + +A +K ++EL NE + LL ++ E++ L A+
Sbjct: 446 HETASQTSFPDVYNEGTQAVTEENIASLQKRVVELE-NE-KGALLLSSIELEE---LKAE 500
Query: 622 VEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLH 681
EK S + T L+ Q + E+D E+ ++ V +
Sbjct: 501 NEKLSSQI-------------TLLEAQNRTGEADREVSEIS--------------IVDIA 533
Query: 682 NNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCE 741
N + S ES LE S ++L L +MKE EE + LQ D +
Sbjct: 534 NKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVL 593
Query: 742 AQQELRTVK 750
Q+E++ ++
Sbjct: 594 DQKEMKQME 602
Score = 56.6 bits (135), Expect = 9e-08
Identities = 92/475 (19%), Positives = 200/475 (42%), Gaps = 57/475 (12%)
Query: 306 GNALRTSGSSSSDVTK--ASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPN 363
G L T S ++K S + + + E I + + ++ + ++ + +
Sbjct: 119 GTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQS 178
Query: 364 SVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILE 423
S + +++Q+ EE LQA L + +Q Q + ++ + + + E
Sbjct: 179 STEMEEFVMMKQQLQEKEE----FISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHE 234
Query: 424 TSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREK 483
Q +A+ ++ +KL L ++ ++EE ++++L
Sbjct: 235 DELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDL----------------- 277
Query: 484 LLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLE----E 539
+QQ+LT + E+ NQ + +++++ E+ L +E ER + ++ + +E E
Sbjct: 278 ---LQQELTAA----EQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAE 330
Query: 540 CRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCN 599
+++ L+ E HL + ++A +A A E + +++ K EK LS
Sbjct: 331 RKLSFHNLQEE----MHHLLEQFEQAGQAQA-ELESRYSALEQKHKAEMEEKTSHILSLQ 385
Query: 600 ELRQELLKANGEIKHVSSLLAKVEKDYS--------YLKEICDHQAEQLSR--TSLKLQE 649
+ QEL A +K +S L + + + + L++ +++++S+ L LQ+
Sbjct: 386 KTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQ 445
Query: 650 KASESDAEIKDM----KETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLER 705
+ S D+ + + E Q R V+L N + L S I+LEE K++ E+
Sbjct: 446 HETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEK--GALLLSSIELEELKAENEK 503
Query: 706 QLKTLT-KQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEK 759
+T + + T E R +++ + V +AN A++ + V ++ K
Sbjct: 504 LSSQITLLEAQNRTGEADREVSEI-SIVDIANKRSSSAEESGQDVLENTFSQKHK 557
Score = 54.3 bits (129), Expect = 4e-07
Identities = 129/670 (19%), Positives = 262/670 (39%), Gaps = 96/670 (14%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDA----LGPNVDGTSV 217
E+ L SQV+EL + + +++ +L L + + +R L+ E A L + S+
Sbjct: 745 ERDQLLSQVKELSMVTELR-AQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSI 803
Query: 218 SPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPT 277
+ I L+ + + Q + S+ R L+ +L E S EGA SS
Sbjct: 804 EAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKE-SEVLEGAERVRHISSKVE 862
Query: 278 SITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFE----- 332
++Q S +M + E K+++ +T VT+ S S +
Sbjct: 863 ELSQALSQKELEITKMDQLLLEKKRDVE-TLQQTIEEKDQQVTEISFSMTEKMVQLNEEK 921
Query: 333 ---HITAETPSRPLSSTSNPFKSSKCS-------TAGSSPN-----SVSELSLASLTEKI 377
+ +T L+ S ++ K ++G N ++S L +
Sbjct: 922 FSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEF 981
Query: 378 QKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLS 437
+++ + +LQA L + Q V L E L DE R E+
Sbjct: 982 DLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEE-D 1040
Query: 438 QENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRK 497
+EN++ +E+ T + + IE+ K T EK + +Q +RK
Sbjct: 1041 KENKEY---------SEKCVTSKCQEIEIYLKQT--------ISEKEVELQH-----IRK 1078
Query: 498 VEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSH 557
EE A E + L ++ +N+ L+ + + +++ + E + ++ L N
Sbjct: 1079 DLEEKLAAEEQFQALVKQ---MNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDG 1135
Query: 558 LQGEKQKATEASAVEQTAES----CEVQEMLKVARAEKDLLELSCNEL----RQELLKAN 609
K T + T S E++E + EK+ L+ E + L KA
Sbjct: 1136 DSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQ 1195
Query: 610 GEIKHVSSLLAKVEKDYSYLKEICDHQA-------EQLSRTSLKLQEK---------ASE 653
+ +H+ L + + DY+ L+E D Q+ +QL + ++++E E
Sbjct: 1196 EKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQE 1255
Query: 654 SDAEIKDMKETIFELEDQ----------------VEQHRAVKLHNNQLISELESSVIKLE 697
S + ++E +F+ +Q A L ++++++ + ++E
Sbjct: 1256 SCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIE 1315
Query: 698 EQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKC---EAQQELRTVKRKLL 754
+K +LE ++ + T ++ +++EE + Q + + +K EA+ ++++KL
Sbjct: 1316 AEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLE 1375
Query: 755 EEEEKNARLQ 764
+ + A L+
Sbjct: 1376 SSQLQIAGLE 1385
Score = 53.1 bits (126), Expect = 1e-06
Identities = 87/438 (19%), Positives = 179/438 (40%), Gaps = 77/438 (17%)
Query: 397 ELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEP 456
+L+ + ++E+ A+ ++ + E +H + + + E EK+ + LQE K E
Sbjct: 103 KLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQE--KEELI 160
Query: 457 TTQEGKI--IELEQKCTGILEQGRF--------EREKLLNI------QQQLTCSLRKVEE 500
+T + ++ + EQ E F E+E+ ++ Q Q + ++V
Sbjct: 161 STLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVR 220
Query: 501 ENQGALEMIKRLKEE---------------NEKLNEF-LELERHNNNMM--AKTLEECRV 542
E E RL E+ +KL +LE H +++ A+ ++ +
Sbjct: 221 EKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQ 280
Query: 543 TLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLE--LSCNE 600
L + N L LQ Q E + + T E+ + + + + E ++ E LS +
Sbjct: 281 ELTAAEQRNQILSQQLQ---QMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHN 337
Query: 601 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTS--LKLQEKASESDAEI 658
L++E+ + + A++E YS L++ H+AE +TS L LQ+ E +
Sbjct: 338 LQEEMHHLLEQFEQAGQAQAELESRYSALEQ--KHKAEMEEKTSHILSLQKTGQELQSAC 395
Query: 659 KDMK------------------ETIFELEDQVEQH--------RAVKLHNNQLISELESS 692
+K +TI +LEDQ++Q + L ++ S+
Sbjct: 396 DALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFP 455
Query: 693 VIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRK 752
+ E ++ E + +L K++ E E + L + + ++K A+ E + +
Sbjct: 456 DVYNEGTQAVTEENIASLQKRVVELENE----KGALLLSSIELEELK--AENEKLSSQIT 509
Query: 753 LLEEEEKNARLQKELGDV 770
LLE + + +E+ ++
Sbjct: 510 LLEAQNRTGEADREVSEI 527
Score = 50.1 bits (118), Expect = 8e-06
Identities = 125/643 (19%), Positives = 244/643 (37%), Gaps = 108/643 (16%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 221
+K LE +R+ A+ + +L ++L+ +E + E + + S+ G
Sbjct: 2334 QKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKI--ISLLSGK 2391
Query: 222 TEPMIRALEEKNKNFQKELSDLE-------EENRVLKEKLIYLEHSPNSEGAASHTGDSS 274
E + A+ E + KE+ +LE EEN VL+E+ + + + T +
Sbjct: 2392 EEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEEN---KKAVDKTNQLMETLKTI 2448
Query: 275 CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI 334
+I Q++ S + S D + I G+ + S + + + E+
Sbjct: 2449 KKENIQQKAQLDSFVKSMSSLQND--RDRIVGDYQQLEERHLSIILEKDQLIQEAAAENN 2506
Query: 335 TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEEL-QA 393
+ R L S + S N+ + L E + ++ S ++L +
Sbjct: 2507 KLKEEIRGLRSHMDDLNSE---------NAKLDAELIQYREDLNQVITIKDSQQKQLLEV 2557
Query: 394 TLQ---ELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQER 450
LQ EL ++ ++E E+E+ ++ L SF+ +E + LS+E E L
Sbjct: 2558 QLQQNKELENKYAKLEEKLKESEEANED---LRRSFNALQEEKQDLSKEIESL------- 2607
Query: 451 VKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIK 510
+ I +L ++ T + E+G T L +
Sbjct: 2608 ---------KVSISQLTRQVTALQEEG--------------TLGLYHAQ----------- 2633
Query: 511 RLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGE-KQKATEAS 569
LK + E+++ L + +A+ EE + + G ++ L+ E K +A
Sbjct: 2634 -LKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAG 2692
Query: 570 AVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYL 629
+ E+ E +VA +DL+ E+ Q+LL E K +++ + + S L
Sbjct: 2693 IMRNETETAEE----RVAELARDLV-----EMEQKLLMVTKENKGLTAQIQSFGRSMSSL 2743
Query: 630 KEICDHQAEQLSRTSLKLQEKASESDAEIKD-----------MKETIFELEDQVEQHRAV 678
+ DH E+L K E A++K+ + ET F + E +
Sbjct: 2744 QNSRDHANEELDELKRKYDASLKEL-AQLKEQGLLNRERDALLSETAFSMNSTEENSLSH 2802
Query: 679 KLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK----------EETEEWRRFQADL 728
NQ + + ++ L Q D Q+++ +K M E E++R+ +
Sbjct: 2803 LEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGK 2862
Query: 729 QTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 771
Q + + E Q ++K+ + + RL KEL ++Q
Sbjct: 2863 QRSAAQPSTSPAEVQ----SLKKAMSSLQNDRDRLLKELKNLQ 2901
Score = 44.3 bits (103), Expect = 4e-04
Identities = 57/230 (24%), Positives = 99/230 (43%), Gaps = 36/230 (15%)
Query: 561 EKQKATEASAVEQTAESCEVQEMLKVARAEKDL-LELSCNELRQELLKANGEIK----HV 615
E T+ E+ A + ++ LK +KD+ L+ L++E A+ +IK H
Sbjct: 41 EFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHA 100
Query: 616 SSLLAKVEKDYSYLKEICDH-----QAEQLSRTSLKLQEKAS-ESDAEIKDMKETIFELE 669
+ L + K Y++E+ E S L +K+S E + EI+ +K + E E
Sbjct: 101 KAKLTSLNK---YIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKE 157
Query: 670 D-----QVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWR-- 722
+ Q + +A Q +E+E V+ +++Q + E + TL Q+ + E
Sbjct: 158 ELISTLQAQLTQAQAEQPAQSSTEMEEFVM-MKQQLQEKEEFISTLQAQLSQTQAEQAAQ 216
Query: 723 --------------RFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEE 758
R D +V D++ E QQ+LR ++RKL E EE
Sbjct: 217 QVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEE 266
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 85.9 bits (211), Expect = 1e-16
Identities = 143/640 (22%), Positives = 273/640 (42%), Gaps = 108/640 (16%)
Query: 171 RELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALE 230
R+ L + K +++L SE+ +YKE R + E A + + +T+ M+
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKE-RLHDIEFYKARVEELKEDNQVLLETKTMLEDQL 367
Query: 231 EKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTG 290
E + +L +LE+EN LK KL +E
Sbjct: 368 EGTRARSDKLHELEKENLQLKAKLHDME-------------------------------- 395
Query: 291 NQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPF 350
M D+D K L + K S+ D S E SR + P
Sbjct: 396 --MERDMDRKKIE----ELMEENMTLEMAQKQSM--DESLHLGWELEQISRTSELSEAPQ 447
Query: 351 KSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTA 410
KS + V+EL+ + L K++ ++ T EEL+ T+ + + ++
Sbjct: 448 KSLG--------HEVNELTSSRLL-KLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498
Query: 411 ENEKLVDEKTILETSFHQHR---ERAEQLSQENEKLMNLLQERVKN-EEPTTQEGKIIE- 465
EN++L + ILE Q + + + LS++ K L++ ++ E + ++ KI+E
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558
Query: 466 ----LEQKCTGILEQGRFERE----------KLLNIQQQLTCS-LRKVEEENQGALEMIK 510
L Q + + ++ + E K+L+ + T S L K+E E + + ++
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 511 RLKEENEKLNEFLELERHN----NNMMAKTLEECRVTLE----------GLKMENGSLKS 556
KE+ E+ E LE E H+ N ++ K + ++T E L+ EN LK
Sbjct: 619 HYKEKGERAEE-LENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677
Query: 557 HLQGEKQKATEASAVEQ-----TAESCEVQ---EMLKVARAEKDLLELSCNELRQELLKA 608
L K + ++E+ E+ E++ E LK A + L+L EL E +
Sbjct: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737
Query: 609 NGEIKHVSSLLAKVEK-DYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFE 667
++ + + K E+ + SY + D + ++L +T +K + ++E++D+ E
Sbjct: 738 KKGLELLKASFKKTERLEVSY--QGLDIENQRLQKTLENSNKKIQQLESELQDL-----E 790
Query: 668 LEDQVEQHRAVKLH-NNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQA 726
+E+Q Q +L +++ + +LE LE++ S LE+ K L K+ K R QA
Sbjct: 791 MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR-----LRQQA 845
Query: 727 DLQTAVVVANDIKC-EAQQELRTVKRKLLEEEEKNARLQK 765
+++ + N++K ++E +T+ +++ +E RL++
Sbjct: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
Score = 83.6 bits (205), Expect = 7e-16
Identities = 131/573 (22%), Positives = 238/573 (41%), Gaps = 86/573 (15%)
Query: 221 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSIT 280
++E I+ LE++N++ + +S L + +++ E + N S SS + I
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607
Query: 281 QESSFGSPTGNQMSSDIDEYKKN----------IHG----NALRTSGSSSSDVTKASLSP 326
E Q+ +++ YK+ +H N L ++ +T +
Sbjct: 608 FEK-------RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKI-- 658
Query: 327 DASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENH-- 384
+A + E+ E +R L T + FK+ L SL ++ +++E +
Sbjct: 659 EALEQENSELERENRKLKKTLDSFKNLT-------------FQLESLEKENSQLDEENLE 705
Query: 385 -HSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQ----E 439
E L+ +++ Q +EL +E E+L +L+ SF + ER E Q E
Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKK-TERLEVSYQGLDIE 764
Query: 440 NEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVE 499
N++L L+ K + E + +E+E + Q E K+ + + L ++E
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQDLEMENQTL----QKNLEELKISSKR------LEQLE 814
Query: 500 EENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQ 559
+EN+ + +L+++ ++L + + R + TLEE V + L+ EN +L +
Sbjct: 815 KENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIG 874
Query: 560 GEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLL 619
K+ +E+ E +E++K A + L +L E LK + L
Sbjct: 875 IYKESCVRLKELEK-----ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLT 929
Query: 620 AKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASES----DAEIKDMKETIFELEDQVEQH 675
++EK KE H + + KL E ES EIK+ E I LE ++E+
Sbjct: 930 HELEK-IGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKE--EKIAALEARLEES 986
Query: 676 RAVKLHNNQLISELESSVIKLE--EQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVV 733
+N QL EL++ E +Q+ D ER +++ + + E +W R
Sbjct: 987 TN---YNQQLRQELKTVKKNYEALKQRQDEERMVQS-SPPISGEDNKWERESQ------- 1035
Query: 734 VANDIKCEAQQELRTVKRKLLEEEEKNARLQKE 766
E +EL VK +L+E E NA LQ E
Sbjct: 1036 -------ETTRELLKVKDRLIEVERNNATLQAE 1061
Score = 81.3 bits (199), Expect = 3e-15
Identities = 140/628 (22%), Positives = 254/628 (40%), Gaps = 91/628 (14%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 221
E L ++E ++ + E +++ EL+ YKEK E + L +
Sbjct: 588 ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK----GERAEELENELHHLEKENEL 643
Query: 222 TEPMIRALE---EKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTS 278
+ I L+ EK + ++E S+LE ENR LK+ L DS +
Sbjct: 644 LQKKITNLKITCEKIEALEQENSELERENRKLKKTL-----------------DSFKNLT 686
Query: 279 ITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAET 338
ES + +S +DE + N + AS+ E+ E+
Sbjct: 687 FQLESL------EKENSQLDEENLELRRNV--------ESLKCASMKMAQLQLENKELES 732
Query: 339 PSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQEL 398
L K+S T VS L +++QK EN + ++L++ LQ+L
Sbjct: 733 EKEQLKKGLELLKASFKKTERLE---VSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 399 SDQQQMVQELTAEN-------EKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERV 451
+ Q +Q+ E E+L E LE Q + +QL +EN++L Q +
Sbjct: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ--QAEI 847
Query: 452 KNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKR 511
K+ TT E +++ G LE+ K + I ++ L+++E+EN+ E++KR
Sbjct: 848 KD---TTLEENNVKI-----GNLEKENKTLSKEIGIYKESCVRLKELEKENK---ELVKR 896
Query: 512 LKEENEKL---NEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQG---EKQKA 565
+ + L E L E+ M LE+ LE + + L Q + K
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKL 956
Query: 566 TEASAVEQTAESCEVQEMLKVARAEKDLLELSC--NELRQELLKANGEIKHVSSLLAKVE 623
E+ +S E++E K+A E L E + +LRQEL V+
Sbjct: 957 LESKLESTLKKSLEIKEE-KIAALEARLEESTNYNQQLRQEL--------------KTVK 1001
Query: 624 KDYSYLKEICDHQ-----AEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAV 678
K+Y LK+ D + + +S K + ++ E+ E+ +K+ + E+E +A
Sbjct: 1002 KNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAE 1061
Query: 679 KLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDI 738
K + +LE+ L+ Q L+RQ +L +Q T + + + ++ + + +
Sbjct: 1062 KQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ--NTTLQTQNAKLQVENSTLNSQST 1119
Query: 739 KCEAQQELRTVKRKLLEEEEKNARLQKE 766
Q +++ LE E ++ ++E
Sbjct: 1120 SLMNQNAQLLIQQSSLENENESVIKERE 1147
Score = 72.0 bits (175), Expect = 2e-12
Identities = 90/436 (20%), Positives = 194/436 (44%), Gaps = 21/436 (4%)
Query: 349 PFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQEL 408
P SS + SP S L+ ++ + +EL+ ++L D +Q ++++
Sbjct: 225 PHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQM 284
Query: 409 TAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQ 468
E ++L E L + R ++L EK + + +++++E +E ++ ++E
Sbjct: 285 EIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV--DKLESEVSRYKE-RLHDIEF 341
Query: 469 KCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERH 528
+ E+ + + + LL + L L + E+ K + KL++ +E+ER
Sbjct: 342 YKARV-EELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHD-MEMERD 399
Query: 529 NNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQ---KATEASAVEQTAESCEVQEMLK 585
+ + L E +TLE + ++ HL E + + +E S Q + EV E+
Sbjct: 400 MDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTS 459
Query: 586 VARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLK---EICDHQAEQLSR 642
+ ++ S + +EL ++ +S + K+EK+ L EI +++ Q +
Sbjct: 460 SRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQ 519
Query: 643 TSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKL------HNNQLISEL-ESSVIK 695
+ Q + + E +++TI L + E R +K+ H NQ +S L + S I
Sbjct: 520 SLQNCQNLSKDLMKEKAQLEKTIETLRENSE--RQIKILEQENEHLNQTVSSLRQRSQIS 577
Query: 696 LEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLE 755
E + D+E++ K L + +KE + + + + + + K E + ++ +L
Sbjct: 578 AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK-EKGERAEELENELHH 636
Query: 756 EEEKNARLQKELGDVQ 771
E++N LQK++ +++
Sbjct: 637 LEKENELLQKKITNLK 652
Score = 35.8 bits (81), Expect = 0.16
Identities = 68/333 (20%), Positives = 126/333 (37%), Gaps = 40/333 (12%)
Query: 226 IRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSF 285
++ LE +N N Q ++ L+ + L+E+ L+ + T +S + + Q +
Sbjct: 1069 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1128
Query: 286 ---GSPTGNQMSSDIDEYK--KNIHGNALRTSGSSSSDVTKASLSPD--ASDFE------ 332
S N+ S I E + K+++ + ++ D K L + AS++E
Sbjct: 1129 LIQQSSLENENESVIKEREDLKSLYDSLIK-------DHEKLELLHERQASEYESLISKH 1181
Query: 333 ------HITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHS 386
H E R L N K E L EK+ +NH +
Sbjct: 1182 GTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL------EKMLKVEQEKMLLENKNHET 1235
Query: 387 TAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNL 446
A E + E +L E E L + L++ + + +L E KL
Sbjct: 1236 VAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQ 1295
Query: 447 LQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGAL 506
Q+ + +T+ EL + G LE+ E LL+ Q L R + E+N +
Sbjct: 1296 YQQL---DITSTKLNNQCELLSQLKGNLEE---ENRHLLDQIQTLMLQNRTLLEQNMESK 1349
Query: 507 EMIKRLKEENEKLNEFLELERHNNNMMAKTLEE 539
++ E+ + +++ EL R + K +++
Sbjct: 1350 DLFH--VEQRQYIDKLNELRRQKEKLEEKIMDQ 1380
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 85.9 bits (211), Expect = 1e-16
Identities = 143/640 (22%), Positives = 273/640 (42%), Gaps = 108/640 (16%)
Query: 171 RELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALE 230
R+ L + K +++L SE+ +YKE R + E A + + +T+ M+
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKE-RLHDIEFYKARVEELKEDNQVLLETKTMLEDQL 367
Query: 231 EKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTG 290
E + +L +LE+EN LK KL +E
Sbjct: 368 EGTRARSDKLHELEKENLQLKAKLHDME-------------------------------- 395
Query: 291 NQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPF 350
M D+D K L + K S+ D S E SR + P
Sbjct: 396 --MERDMDRKKIE----ELMEENMTLEMAQKQSM--DESLHLGWELEQISRTSELSEAPQ 447
Query: 351 KSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTA 410
KS + V+EL+ + L K++ ++ T EEL+ T+ + + ++
Sbjct: 448 KSLG--------HEVNELTSSRLL-KLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498
Query: 411 ENEKLVDEKTILETSFHQHR---ERAEQLSQENEKLMNLLQERVKN-EEPTTQEGKIIE- 465
EN++L + ILE Q + + + LS++ K L++ ++ E + ++ KI+E
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558
Query: 466 ----LEQKCTGILEQGRFERE----------KLLNIQQQLTCS-LRKVEEENQGALEMIK 510
L Q + + ++ + E K+L+ + T S L K+E E + + ++
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 511 RLKEENEKLNEFLELERHN----NNMMAKTLEECRVTLE----------GLKMENGSLKS 556
KE+ E+ E LE E H+ N ++ K + ++T E L+ EN LK
Sbjct: 619 HYKEKGERAEE-LENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677
Query: 557 HLQGEKQKATEASAVEQ-----TAESCEVQ---EMLKVARAEKDLLELSCNELRQELLKA 608
L K + ++E+ E+ E++ E LK A + L+L EL E +
Sbjct: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737
Query: 609 NGEIKHVSSLLAKVEK-DYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFE 667
++ + + K E+ + SY + D + ++L +T +K + ++E++D+ E
Sbjct: 738 KKGLELLKASFKKTERLEVSY--QGLDIENQRLQKTLENSNKKIQQLESELQDL-----E 790
Query: 668 LEDQVEQHRAVKLH-NNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQA 726
+E+Q Q +L +++ + +LE LE++ S LE+ K L K+ K R QA
Sbjct: 791 MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR-----LRQQA 845
Query: 727 DLQTAVVVANDIKC-EAQQELRTVKRKLLEEEEKNARLQK 765
+++ + N++K ++E +T+ +++ +E RL++
Sbjct: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
Score = 82.8 bits (203), Expect = 1e-15
Identities = 141/627 (22%), Positives = 254/627 (40%), Gaps = 90/627 (14%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 221
E L ++E ++ + E +++ EL+ YKEK E + L +
Sbjct: 588 ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK----GERAEELENELHHLEKENEL 643
Query: 222 TEPMIRALE---EKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTS 278
+ I L+ EK + ++E S+LE ENR LK+ L DS +
Sbjct: 644 LQKKITNLKITCEKIEALEQENSELERENRKLKKTL-----------------DSFKNLT 686
Query: 279 ITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAET 338
ES + +S +DE + N + AS+ E+ E+
Sbjct: 687 FQLESL------EKENSQLDEENLELRRNV--------ESLKCASMKMAQLQLENKELES 732
Query: 339 PSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQEL 398
L K+S T VS L +++QK EN + ++L++ LQ+L
Sbjct: 733 EKEQLKKGLELLKASFKKTERLE---VSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 399 SDQQQMVQELTAEN-------EKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERV 451
+ Q +Q+ E E+L E LE Q + +QL +EN++L Q +
Sbjct: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ--QAEI 847
Query: 452 KNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKR 511
K+ TT E +++ G LE+ K + I ++ L+++E+EN+ E++KR
Sbjct: 848 KD---TTLEENNVKI-----GNLEKENKTLSKEIGIYKESCVRLKELEKENK---ELVKR 896
Query: 512 LKEENEKL---NEFLELERHNNNMMAKTLEECRVTLE--GLKMENGSLKSHLQGEKQKAT 566
+ + L E L E+ M LE+ LE GL E ++ K
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLL 956
Query: 567 EASAVEQTAESCEVQEMLKVARAEKDLLELSC--NELRQELLKANGEIKHVSSLLAKVEK 624
E+ +S E++E K+A E L E + +LRQEL V+K
Sbjct: 957 ESKLESTLKKSLEIKEE-KIAALEARLEESTNYNQQLRQEL--------------KTVKK 1001
Query: 625 DYSYLKEICDHQ-----AEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVK 679
+Y LK+ D + + +S K + ++ E+ E+ +K+ + E+E +A K
Sbjct: 1002 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1061
Query: 680 LHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIK 739
+ +LE+ L+ Q L+RQ +L +Q T + + + ++ + + +
Sbjct: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ--NTTLQTQNAKLQVENSTLNSQSTS 1119
Query: 740 CEAQQELRTVKRKLLEEEEKNARLQKE 766
Q +++ LE E ++ ++E
Sbjct: 1120 LMNQNAQLLIQQSSLENENESVIKERE 1146
Score = 81.6 bits (200), Expect = 3e-15
Identities = 133/573 (23%), Positives = 239/573 (41%), Gaps = 87/573 (15%)
Query: 221 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSIT 280
++E I+ LE++N++ + +S L + +++ E + N S SS + I
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607
Query: 281 QESSFGSPTGNQMSSDIDEYKKN----------IHG----NALRTSGSSSSDVTKASLSP 326
E Q+ +++ YK+ +H N L ++ +T +
Sbjct: 608 FEK-------RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKI-- 658
Query: 327 DASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENH-- 384
+A + E+ E +R L T + FK+ L SL ++ +++E +
Sbjct: 659 EALEQENSELERENRKLKKTLDSFKNLT-------------FQLESLEKENSQLDEENLE 705
Query: 385 -HSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQ----E 439
E L+ +++ Q +EL +E E+L +L+ SF + ER E Q E
Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKK-TERLEVSYQGLDIE 764
Query: 440 NEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVE 499
N++L L+ K + E + +E+E + Q E K+ + + L ++E
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQDLEMENQTL----QKNLEELKISSKR------LEQLE 814
Query: 500 EENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQ 559
+EN+ + +L+++ ++L + + R + TLEE V + L+ EN +L +
Sbjct: 815 KENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIG 874
Query: 560 GEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLL 619
K+ +E+ E +E++K A + L +L E LK + L
Sbjct: 875 IYKESCVRLKELEK-----ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLT 929
Query: 620 AKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASES----DAEIKDMKETIFELEDQVEQH 675
++EK KE H EQ + KL E ES EIK+ E I LE ++E+
Sbjct: 930 HELEK-IGLNKERLLHD-EQSTDDRYKLLESKLESTLKKSLEIKE--EKIAALEARLEES 985
Query: 676 RAVKLHNNQLISELESSVIKLE--EQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVV 733
+N QL EL++ E +Q+ D ER +++ + + E +W R
Sbjct: 986 TN---YNQQLRQELKTVKKNYEALKQRQDEERMVQS-SPPISGEDNKWERESQ------- 1034
Query: 734 VANDIKCEAQQELRTVKRKLLEEEEKNARLQKE 766
E +EL VK +L+E E NA LQ E
Sbjct: 1035 -------ETTRELLKVKDRLIEVERNNATLQAE 1060
Score = 72.0 bits (175), Expect = 2e-12
Identities = 90/436 (20%), Positives = 194/436 (44%), Gaps = 21/436 (4%)
Query: 349 PFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQEL 408
P SS + SP S L+ ++ + +EL+ ++L D +Q ++++
Sbjct: 225 PHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQM 284
Query: 409 TAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQ 468
E ++L E L + R ++L EK + + +++++E +E ++ ++E
Sbjct: 285 EIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV--DKLESEVSRYKE-RLHDIEF 341
Query: 469 KCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERH 528
+ E+ + + + LL + L L + E+ K + KL++ +E+ER
Sbjct: 342 YKARV-EELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHD-MEMERD 399
Query: 529 NNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQ---KATEASAVEQTAESCEVQEMLK 585
+ + L E +TLE + ++ HL E + + +E S Q + EV E+
Sbjct: 400 MDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTS 459
Query: 586 VARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLK---EICDHQAEQLSR 642
+ ++ S + +EL ++ +S + K+EK+ L EI +++ Q +
Sbjct: 460 SRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQ 519
Query: 643 TSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKL------HNNQLISEL-ESSVIK 695
+ Q + + E +++TI L + E R +K+ H NQ +S L + S I
Sbjct: 520 SLQNCQNLSKDLMKEKAQLEKTIETLRENSE--RQIKILEQENEHLNQTVSSLRQRSQIS 577
Query: 696 LEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLE 755
E + D+E++ K L + +KE + + + + + + K E + ++ +L
Sbjct: 578 AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK-EKGERAEELENELHH 636
Query: 756 EEEKNARLQKELGDVQ 771
E++N LQK++ +++
Sbjct: 637 LEKENELLQKKITNLK 652
Score = 35.8 bits (81), Expect = 0.16
Identities = 68/333 (20%), Positives = 126/333 (37%), Gaps = 40/333 (12%)
Query: 226 IRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSF 285
++ LE +N N Q ++ L+ + L+E+ L+ + T +S + + Q +
Sbjct: 1068 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127
Query: 286 ---GSPTGNQMSSDIDEYK--KNIHGNALRTSGSSSSDVTKASLSPD--ASDFE------ 332
S N+ S I E + K+++ + ++ D K L + AS++E
Sbjct: 1128 LIQQSSLENENESVIKEREDLKSLYDSLIK-------DHEKLELLHERQASEYESLISKH 1180
Query: 333 ------HITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHS 386
H E R L N K E L EK+ +NH +
Sbjct: 1181 GTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL------EKMLKVEQEKMLLENKNHET 1234
Query: 387 TAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNL 446
A E + E +L E E L + L++ + + +L E KL
Sbjct: 1235 VAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQ 1294
Query: 447 LQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGAL 506
Q+ + +T+ EL + G LE+ E LL+ Q L R + E+N +
Sbjct: 1295 YQQL---DITSTKLNNQCELLSQLKGNLEE---ENRHLLDQIQTLMLQNRTLLEQNMESK 1348
Query: 507 EMIKRLKEENEKLNEFLELERHNNNMMAKTLEE 539
++ E+ + +++ EL R + K +++
Sbjct: 1349 DLFH--VEQRQYIDKLNELRRQKEKLEEKIMDQ 1379
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.304 0.121 0.316
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,972,140
Number of Sequences: 37866
Number of extensions: 1391307
Number of successful extensions: 18554
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 425
Number of HSP's successfully gapped in prelim test: 1292
Number of HSP's that attempted gapping in prelim test: 7888
Number of HSP's gapped (non-prelim): 6642
length of query: 790
length of database: 18,247,518
effective HSP length: 110
effective length of query: 680
effective length of database: 14,082,258
effective search space: 9575935440
effective search space used: 9575935440
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.