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Search of human proteins with 75677325
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|75677325 kinase suppressor of ras [Homo sapiens]
(762 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|75677325 kinase suppressor of ras [Homo sapiens] 1570 0.0
gi|167621456 kinase suppressor of ras 2 [Homo sapiens] 653 0.0
gi|33188459 B-Raf [Homo sapiens] 194 3e-49
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom... 181 2e-45
gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Hom... 181 2e-45
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 116 7e-26
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 109 1e-23
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 109 1e-23
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 108 1e-23
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 105 1e-22
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 105 2e-22
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 103 6e-22
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 103 6e-22
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 101 2e-21
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 101 3e-21
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] 93 1e-18
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 92 1e-18
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 92 2e-18
gi|4826776 Janus kinase 2 [Homo sapiens] 91 3e-18
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 91 5e-18
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 91 5e-18
gi|66932999 testis-specific protein kinase 1 [Homo sapiens] 90 9e-18
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 88 3e-17
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 88 3e-17
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 88 3e-17
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 87 4e-17
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 87 4e-17
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 87 4e-17
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 87 8e-17
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 87 8e-17
>gi|75677325 kinase suppressor of ras [Homo sapiens]
Length = 762
Score = 1570 bits (4066), Expect = 0.0
Identities = 762/762 (100%), Positives = 762/762 (100%)
Query: 1 MNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGEHKEDSSWSSLDARRESGSGPS 60
MNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGEHKEDSSWSSLDARRESGSGPS
Sbjct: 1 MNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGEHKEDSSWSSLDARRESGSGPS 60
Query: 61 TDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPTPSFSEGLSDTCIPLHAS 120
TDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPTPSFSEGLSDTCIPLHAS
Sbjct: 61 TDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPTPSFSEGLSDTCIPLHAS 120
Query: 121 GRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLG 180
GRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLG
Sbjct: 121 GRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLG 180
Query: 181 NRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKHCR 240
NRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKHCR
Sbjct: 181 NRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKHCR 240
Query: 241 LKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKEHPP 300
LKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKEHPP
Sbjct: 241 LKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKEHPP 300
Query: 301 AMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHHR 360
AMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHHR
Sbjct: 301 AMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHHR 360
Query: 361 QQFIFPVPSAGHCWKCLLIAESLKENAFNISAFAHAAPLPEAADGTRLDDQPKADVLEAH 420
QQFIFPVPSAGHCWKCLLIAESLKENAFNISAFAHAAPLPEAADGTRLDDQPKADVLEAH
Sbjct: 361 QQFIFPVPSAGHCWKCLLIAESLKENAFNISAFAHAAPLPEAADGTRLDDQPKADVLEAH 420
Query: 421 EAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGE 480
EAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGE
Sbjct: 421 EAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGE 480
Query: 481 PIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACM 540
PIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACM
Sbjct: 481 PIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACM 540
Query: 541 NPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSK 600
NPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSK
Sbjct: 541 NPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSK 600
Query: 601 NVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLP 660
NVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLP
Sbjct: 601 NVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLP 660
Query: 661 FSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILS 720
FSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILS
Sbjct: 661 FSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILS 720
Query: 721 ACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSAEL 762
ACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSAEL
Sbjct: 721 ACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSAEL 762
>gi|167621456 kinase suppressor of ras 2 [Homo sapiens]
Length = 921
Score = 653 bits (1684), Expect = 0.0
Identities = 334/575 (58%), Positives = 422/575 (73%), Gaps = 32/575 (5%)
Query: 197 SPQMVRRDIGLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRI 256
SPQ+ RRD+G S+ HRFSTK W+SQ C VC K M+FG+KCK+C+LKCHNKCTKEAP C +
Sbjct: 370 SPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHL 429
Query: 257 SFLPL---TRLRRTESVPSDINNPV---DRAAEPHFG-TLPKA-LTKKEHPPAMNHLDSS 308
+ RL RTESVP DINNP+ R ++ H TLPK K+H P DSS
Sbjct: 430 LIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSS 489
Query: 309 SNPSSTTSSTPSSPAP-FPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFPV 367
SNPSSTTSSTPSSPAP P S+ P S P +P ++ FN PA+++ ++QQFIFP
Sbjct: 490 SNPSSTTSSTPSSPAPPLPPSATPPSPLHP-SPQCTRQQKNFNLPASHYYKYKQQFIFP- 547
Query: 368 PSAGHCWKCLLIAESLKENAFNISAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEP 427
+ + E+ I + P+ E +++ +P ++ E H+
Sbjct: 548 -------DVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHD------ 594
Query: 428 EAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRW 487
EAE+ ED+ +++ S R RKASQTS++LQEWDIPFEQ+E+GE IG+GR+
Sbjct: 595 -----EAEESEDDFEEMNLSLLSARS-FPRKASQTSIFLQEWDIPFEQLEIGELIGKGRF 648
Query: 488 GRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAI 547
G+V+ GRWHGEVAIRL++++ N+D LK FK+EVM YRQTRHENVVLFMGACM+PPHLAI
Sbjct: 649 GQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAI 708
Query: 548 ITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNG 607
ITS CKGRTL+S VRD K LD+NKTRQIAQEI+KGMGYLHAKGI+HKDLKSKNVFYDNG
Sbjct: 709 ITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNG 768
Query: 608 KVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADV 667
KVVITDFGLF ISGV++ GRRE++L++ + WLC+LAPEI+R+++P +ED+LPFSK +DV
Sbjct: 769 KVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDV 828
Query: 668 YAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDL 727
+A GT+WYEL AR+WP K Q AEA IWQ+G+ GMK L+ + +GKE+S+IL CWAF+
Sbjct: 829 FALGTIWYELHAREWPFKTQPAEAIIWQMGT--GMKPNLSQIGMGKEISDILLFCWAFEQ 886
Query: 728 QERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSAEL 762
+ERP+F+ LMDMLEKLPK NRRLSHPGHFWKSAEL
Sbjct: 887 EERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL 921
Score = 94.7 bits (234), Expect = 3e-19
Identities = 74/214 (34%), Positives = 101/214 (47%), Gaps = 40/214 (18%)
Query: 1 MNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGE-HKEDSSWSSLDARRESGSGP 59
M + +V ET+ + GA+ +EC RL +L+CLR V GG K+D W+ P
Sbjct: 93 MTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQD--WTI--------QWP 142
Query: 60 STDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALP-ASDSPTPSFS----------E 108
+T+T + PP + R + +Q PR S SPTP +
Sbjct: 143 TTETGKENNPVCPPEPTPWIRT-HLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVD 201
Query: 109 GLSDTCIPL-----HASGRLTPRALHSF------------ITPPTTPQLRRHTKLKPPRT 151
C P H S +PR H+ +TPP TP +R+ KLKPP T
Sbjct: 202 AYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGT 261
Query: 152 PPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDD 185
PPP SRK+ L+P F L RSKSHE QLG+R+D+
Sbjct: 262 PPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDE 295
>gi|33188459 B-Raf [Homo sapiens]
Length = 766
Score = 194 bits (493), Expect = 3e-49
Identities = 160/556 (28%), Positives = 257/556 (46%), Gaps = 70/556 (12%)
Query: 210 THRFSTKSWLSQV-CHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPLTRLRRTE 268
TH F K++ + C C+K + G +C+ C K H +C+ E P +++ L L ++
Sbjct: 234 THNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSK 293
Query: 269 SVPSDINNPVDRAAEPHFGTLPKALTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTS 328
++P+ + T ALT P A S P TS +PS P P
Sbjct: 294 FFE---HHPIPQEEASLAET---ALTSGSSPSAP--ASDSIGPQILTSPSPSKSIPIPQP 345
Query: 329 SNPSSATTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKENAF 388
P A GQRD + P + I PV I + +++ F
Sbjct: 346 FRP--ADEDHRNQFGQRDRSSSAPNVHI-----NTIEPVN----------IDDLIRDQGF 388
Query: 389 NI---SAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLP 445
S +A P + G+ +V ++ + E S + +D + + L
Sbjct: 389 RGDGGSTTGLSATPPASLPGSL------TNVKALQKSPGPQRERKSSSSSEDRNRMKTL- 441
Query: 446 SSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLE 505
R+ S +W+IP Q+ +G+ IG G +G V++G+WHG+VA+++L
Sbjct: 442 ----------GRRDSS-----DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLN 486
Query: 506 MDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPK 565
+ L+ FK EV R+TRH N++LFMG P LAI+T +C+G +L+ + +
Sbjct: 487 VTAPTPQQLQAFKNEVGVLRKTRHVNILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHIIE 545
Query: 566 TSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVF-YDNGKVVITDFGLFGISGVVR 624
T ++ K IA++ +GM YLHAK I+H+DLKS N+F +++ V I DFGL +
Sbjct: 546 TKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS 605
Query: 625 EGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPL 684
+ QL S W +APE++R +D+ P+S +DVYAFG V YEL P
Sbjct: 606 GSHQFEQLSGSILW---MAPEVIRM------QDKNPYSFQSDVYAFGIVLYELMTGQLPY 656
Query: 685 KN-QAAEASIWQIGSGEGMKRVLTSV--SLGKEVSEILSACWAFDLQERPSFSLLMDMLE 741
N + I+ +G G + L+ V + K + +++ C ERP F ++ +E
Sbjct: 657 SNINNRDQIIFMVGRGY-LSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 715
Query: 742 ----KLPKLNRRLSHP 753
LPK++R S P
Sbjct: 716 LLARSLPKIHRSASEP 731
>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
sapiens]
Length = 648
Score = 181 bits (460), Expect = 2e-45
Identities = 145/551 (26%), Positives = 248/551 (45%), Gaps = 72/551 (13%)
Query: 210 THRFSTKSWLSQV-CHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPLTRLRRTE 268
TH F+ K++L C +CQK ++ G +C+ C K H C+ + P + + + +R+
Sbjct: 138 THNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDW---SNIRQLL 194
Query: 269 SVPSDINNPVDRAAEPHFGTLPKALTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTS 328
P+ A P + P + H S+ + + +S+PSS
Sbjct: 195 LFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSL--- 251
Query: 329 SNPSSATTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKENAF 388
S +T+ PN H PV S +I ++++ ++
Sbjct: 252 SQRQRSTSTPNV------------------HMVSTTLPVDSR-------MIEDAIRSHSE 286
Query: 389 NISAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSR 448
+ S A ++ P T QPK V E P +G E
Sbjct: 287 SASPSALSSS-PNNLSPTGWS-QPKTPVPAQRE---RAPVSGTQE--------------- 326
Query: 449 RPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDG 508
+ I + + S Y W+I +V L IG G +G V++G+WHG+VA+++L++
Sbjct: 327 ---KNKIRPRGQRDSSYY--WEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVD 381
Query: 509 HNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSL 568
+ + F+ EV R+TRH N++LFMG M +LAI+T +C+G +L+ + +T
Sbjct: 382 PTPEQFQAFRNEVAVLRKTRHVNILLFMG-YMTKDNLAIVTQWCEGSSLYKHLHVQETKF 440
Query: 569 DINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRR 628
+ + IA++ +GM YLHAK I+H+D+KS N+F G V G FG++ V
Sbjct: 441 QMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTV--KIGDFGLATVKSRWSG 498
Query: 629 ENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKN-Q 687
Q++ + ++APE++R +D PFS +DVY++G V YEL + P +
Sbjct: 499 SQQVEQPTGSVLWMAPEVIRM------QDNNPFSFQSDVYSYGIVLYELMTGELPYSHIN 552
Query: 688 AAEASIWQIGSGEGMKRVLTSV-SLGKEVSEILSACWAFDLQERPSFSLLMDMLE----K 742
+ I+ +G G + + K + +++ C +ERP F ++ +E
Sbjct: 553 NRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHS 612
Query: 743 LPKLNRRLSHP 753
LPK+NR S P
Sbjct: 613 LPKINRSASEP 623
>gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Homo
sapiens]
Length = 606
Score = 181 bits (460), Expect = 2e-45
Identities = 151/563 (26%), Positives = 245/563 (43%), Gaps = 78/563 (13%)
Query: 201 VRRDIGLSVTHRFSTKSWLSQV-CHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFL 259
V D+ L++ H F K++ S C C K + G +C+ C K H C+ + P + +
Sbjct: 90 VLEDVPLTM-HNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVD-M 147
Query: 260 PLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKEHPPAMNHLDSSSNPSSTTSSTP 319
R + SV D++ + P L + LT + P H D
Sbjct: 148 STNRQQFYHSV-QDLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEH---------- 196
Query: 320 SSPAPFPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLI 379
PFP +N +P QR + P + +
Sbjct: 197 ---FPFPAPAN----------APLQRIRSTSTPNVHMVS--------------------T 223
Query: 380 AESLKENAFNISAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDED 439
+ N ++ + + + G+ D P+ A + + KS AE E
Sbjct: 224 TAPMDSNLIQLTGQSFSTDAAGSRGGS--DGTPRGSPSPASVSSGRKSPHSKSPAEQRER 281
Query: 440 E--VDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHG 497
+ DD + + + S Y W++P +V+L + IG G +G V RGRWHG
Sbjct: 282 KSLADD--------KKKVKNLGYRDSGYY--WEVPPSEVQLLKRIGTGSFGTVFRGRWHG 331
Query: 498 EVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTL 557
+VA+++L++ + + FK E+ R+TRH N++LFMG M P AIIT +C+G +L
Sbjct: 332 DVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMG-FMTRPGFAIITQWCEGSSL 390
Query: 558 HSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLF 617
+ + T D+ + +A++ +GM YLHAK I+H+DLKS N+F G V G F
Sbjct: 391 YHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTV--KIGDF 448
Query: 618 GISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYEL 677
G++ V L+ + ++A E++R P P+S +DVYA+G V YEL
Sbjct: 449 GLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPN------PYSFQSDVYAYGVVLYEL 502
Query: 678 QARDWPLKN-QAAEASIWQIGSGEGMKRVLTSVSLG--KEVSEILSACWAFDLQERPSFS 734
P + + I+ +G G + L+ +S K + +LS C F +ERP F
Sbjct: 503 MTGSLPYSHIGCRDQIIFMVGRGY-LSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFP 561
Query: 735 LLMDMLE----KLPKLNRRLSHP 753
++ +E LPK+ R S P
Sbjct: 562 QILATIELLQRSLPKIERSASEP 584
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 116 bits (291), Expect = 7e-26
Identities = 102/362 (28%), Positives = 162/362 (44%), Gaps = 55/362 (15%)
Query: 400 PEAADGTRLDDQPKADVLEAHEAEAEEP--EAGKSEAEDDEDEVDD-------------- 443
P+ +D T D VL+ HE +A P AG E+ D+
Sbjct: 31 PDTSDCTPEKDLTPTHVLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGFLEG 90
Query: 444 LPSSRRPWRGPISRKASQTSVYLQE--WDIPFEQVELGEPIGQGRWGRVHRGRWHGE-VA 500
L RP I + S QE W++PFE++ + +G G G V GR+HGE VA
Sbjct: 91 LFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVA 150
Query: 501 IRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSF 560
++ + L + ++ + R+ +H N++ F G C P I+ FC L+
Sbjct: 151 VKKVR---------DLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEV 201
Query: 561 VRDPKT---SLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVV-ITDFGL 616
+R + SL ++ + IA GM YLH I+H+DLKS N+ VV I+DFG
Sbjct: 202 LRAGRPVTPSLLVDWSMGIAG----GMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFG- 256
Query: 617 FGISGVVREGRRENQLKLSH-DWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWY 675
+ + K+S + ++APE++R P S+ D+++FG V +
Sbjct: 257 ------TSKELSDKSTKMSFAGTVAWMAPEVIRNE---------PVSEKVDIWSFGVVLW 301
Query: 676 ELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSL 735
EL + P K+ + A IW +GS V +S G ++ +L CW + RPSF
Sbjct: 302 ELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKI--LLRQCWNSKPRNRPSFRQ 359
Query: 736 LM 737
++
Sbjct: 360 IL 361
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 109 bits (272), Expect = 1e-23
Identities = 77/281 (27%), Positives = 135/281 (48%), Gaps = 36/281 (12%)
Query: 471 IPFEQVELGEPIGQGRWGRVHRGRWHG---EVAIRLLEMDGHNQDHLKLFKKEVMNYRQT 527
I F+ ++ E G G +G V+R +W EVA++ L LK+ +KE
Sbjct: 11 IKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL---------LKI-EKEAEILSVL 60
Query: 528 RHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTS-LDINKTRQIAQEIIKGMGY 586
H N++ F G + PP+ I+T + +L+ ++ ++ +D++ A ++ KGM Y
Sbjct: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120
Query: 587 LHAKG---IVHKDLKSKNVFYD-NGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYL 642
LH + ++H+DLKS+NV +G + I DFG + L + W+
Sbjct: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFG----ASRFHNHTTHMSLVGTFPWM--- 173
Query: 643 APEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGM 702
APE+++ LP S+ D Y++G V +E+ R+ P K W + E
Sbjct: 174 APEVIQS---------LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVV--EKN 222
Query: 703 KRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKL 743
+R+ S + +E+L CW D ++RPSF ++ +LE +
Sbjct: 223 ERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESM 263
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 109 bits (272), Expect = 1e-23
Identities = 77/281 (27%), Positives = 135/281 (48%), Gaps = 36/281 (12%)
Query: 471 IPFEQVELGEPIGQGRWGRVHRGRWHG---EVAIRLLEMDGHNQDHLKLFKKEVMNYRQT 527
I F+ ++ E G G +G V+R +W EVA++ L LK+ +KE
Sbjct: 11 IKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL---------LKI-EKEAEILSVL 60
Query: 528 RHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTS-LDINKTRQIAQEIIKGMGY 586
H N++ F G + PP+ I+T + +L+ ++ ++ +D++ A ++ KGM Y
Sbjct: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120
Query: 587 LHAKG---IVHKDLKSKNVFYD-NGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYL 642
LH + ++H+DLKS+NV +G + I DFG + L + W+
Sbjct: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFG----ASRFHNHTTHMSLVGTFPWM--- 173
Query: 643 APEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGM 702
APE+++ LP S+ D Y++G V +E+ R+ P K W + E
Sbjct: 174 APEVIQS---------LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVV--EKN 222
Query: 703 KRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKL 743
+R+ S + +E+L CW D ++RPSF ++ +LE +
Sbjct: 223 ERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESM 263
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 108 bits (271), Expect = 1e-23
Identities = 78/289 (26%), Positives = 138/289 (47%), Gaps = 39/289 (13%)
Query: 470 DIPFEQVELGEPIGQGRWGRVHRGRWHGE-VAIRLLEMDGHNQDHLKLFK--KEVMNYRQ 526
+IPF +++L E IG G +G+V+R W GE VA++ +D + + +E +
Sbjct: 92 EIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGA 151
Query: 527 TRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGY 586
+H N++ GAC+NPPHL ++ + +G L + + + A ++ +GM Y
Sbjct: 152 LQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHV--LVNWAVQVARGMNY 209
Query: 587 LHAKG---IVHKDLKSKNVF----YDNGKVV-----ITDFGLFGISGVVREGRRENQLKL 634
LH I+H+DLKS N+ +N + ITDFGL RE + ++
Sbjct: 210 LHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGL------AREWHKTTKMSA 263
Query: 635 SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIW 694
+ + ++APE++R FSK++DV++FG + +EL + P + E
Sbjct: 264 AGTY-AWMAPEVIRLSL---------FSKSSDVWSFGVLLWELLTGEVPYR----EIDAL 309
Query: 695 QIGSGEGMKRVLTSV--SLGKEVSEILSACWAFDLQERPSFSLLMDMLE 741
+ G M ++ + + + + +L CW D RP F ++ LE
Sbjct: 310 AVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLE 358
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 105 bits (263), Expect = 1e-22
Identities = 80/292 (27%), Positives = 141/292 (48%), Gaps = 39/292 (13%)
Query: 466 LQEWDIPFEQVELGEPIGQGRWGRVHRGRWHG-EVAIRLLEMDGHNQ--DHLKLFKKEVM 522
+Q +I F ++ L E IG G +G+V+R W G EVA++ D ++ ++E
Sbjct: 134 IQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAK 193
Query: 523 NYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIK 582
+ +H N++ G C+ P+L ++ F +G L+ + + DI A +I +
Sbjct: 194 LFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDI--LVNWAVQIAR 251
Query: 583 GMGYLHAKGIV---HKDLKSKNVF----YDNGK-----VVITDFGLFGISGVVREGRREN 630
GM YLH + IV H+DLKS N+ +NG + ITDFGL RE R
Sbjct: 252 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGL------AREWHRTT 305
Query: 631 QLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAE 690
++ + + ++APE++R FSK +DV+++G + +EL + P +
Sbjct: 306 KMSAAGTY-AWMAPEVIRASM---------FSKGSDVWSYGVLLWELLTGEVPFRGIDGL 355
Query: 691 ASIWQIGSGEGMKRVLTSV--SLGKEVSEILSACWAFDLQERPSFSLLMDML 740
A + G M ++ + + + ++++ CW D RPSF+ ++D L
Sbjct: 356 A----VAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL 403
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 105 bits (261), Expect = 2e-22
Identities = 79/300 (26%), Positives = 143/300 (47%), Gaps = 50/300 (16%)
Query: 471 IPFEQVELGEPIGQGRWGRVHRGRWHG-EVAIRLLEMDGHNQDHL--KLFKKEVMNYRQT 527
+ FE++EL E IG G +G+V+R W G EVA++ D + ++E +
Sbjct: 119 VAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAML 178
Query: 528 RHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLD-----INKTRQI------ 576
RH N++ G C+ PHL ++ F +G L+ + + D + R+I
Sbjct: 179 RHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLV 238
Query: 577 --AQEIIKGMGYLHAKG---IVHKDLKSKNVF------YD---NGKVVITDFGLFGISGV 622
A +I +GM YLH + I+H+DLKS N+ +D N + ITDFGL
Sbjct: 239 NWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGL------ 292
Query: 623 VREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDW 682
RE R ++ + + ++APE+++ FSK +D++++G + +EL +
Sbjct: 293 AREWHRTTKMSTAGTY-AWMAPEVIKSSL---------FSKGSDIWSYGVLLWELLTGEV 342
Query: 683 PLKNQAAEASIWQIGSGEGMKRVLTSV--SLGKEVSEILSACWAFDLQERPSFSLLMDML 740
P + A + G + ++ + + + ++++ CW D RPSF+L+++ L
Sbjct: 343 PYRGIDGLA----VAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQL 398
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 103 bits (257), Expect = 6e-22
Identities = 83/281 (29%), Positives = 141/281 (50%), Gaps = 26/281 (9%)
Query: 471 IPFEQVELGEPIGQGRWGRVHRGRWHGE-VAIRLLEMDGH-NQDHLKLFKKEVMNYRQTR 528
+ ++E E IG G +G+V++GR + VAI+ + + ++ + +F +EV Q
Sbjct: 458 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN 517
Query: 529 HENVVLFMGACMNPP-HLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYL 587
H V+ F+GAC+N P AI+T + G +L S + + K LD+ IA ++ KGM YL
Sbjct: 518 HPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYL 577
Query: 588 H--AKGIVHKDLKSKNV-FYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAP 644
H + I+H+DL S N+ Y++G V+ D FG S ++ +N K + L ++AP
Sbjct: 578 HNLTQPIIHRDLNSHNILLYEDGHAVVAD---FGESRFLQSLDEDNMTKQPGN-LRWMAP 633
Query: 645 EIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWP---LKNQAAEASIWQIGSGEG 701
E+ + T ++ ADV+++ +E+ + P LK AA A +
Sbjct: 634 EVFTQCT--------RYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADM-----AYH 680
Query: 702 MKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEK 742
R S+ K +S +L W + RP FS ++ LE+
Sbjct: 681 HIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEE 721
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 103 bits (257), Expect = 6e-22
Identities = 83/281 (29%), Positives = 141/281 (50%), Gaps = 26/281 (9%)
Query: 471 IPFEQVELGEPIGQGRWGRVHRGRWHGE-VAIRLLEMDGH-NQDHLKLFKKEVMNYRQTR 528
+ ++E E IG G +G+V++GR + VAI+ + + ++ + +F +EV Q
Sbjct: 559 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN 618
Query: 529 HENVVLFMGACMNPP-HLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYL 587
H V+ F+GAC+N P AI+T + G +L S + + K LD+ IA ++ KGM YL
Sbjct: 619 HPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYL 678
Query: 588 H--AKGIVHKDLKSKNV-FYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAP 644
H + I+H+DL S N+ Y++G V+ D FG S ++ +N K + L ++AP
Sbjct: 679 HNLTQPIIHRDLNSHNILLYEDGHAVVAD---FGESRFLQSLDEDNMTKQPGN-LRWMAP 734
Query: 645 EIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWP---LKNQAAEASIWQIGSGEG 701
E+ + T ++ ADV+++ +E+ + P LK AA A +
Sbjct: 735 EVFTQCT--------RYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADM-----AYH 781
Query: 702 MKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEK 742
R S+ K +S +L W + RP FS ++ LE+
Sbjct: 782 HIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEE 822
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 101 bits (252), Expect = 2e-21
Identities = 72/288 (25%), Positives = 136/288 (47%), Gaps = 39/288 (13%)
Query: 473 FEQVELGEPIGQGRWGRVHRGRWHGE-VAIRLLEMDGHNQDHL--KLFKKEVMNYRQTRH 529
F+++ L E IG G +G+V+RG W GE VA++ D + + ++E + H
Sbjct: 114 FQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAH 173
Query: 530 ENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHA 589
N++ C+ P+L ++ + G L + + + A +I +GM YLH
Sbjct: 174 PNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHV--LVNWAVQIARGMHYLHC 231
Query: 590 KG---IVHKDLKSKNVF---------YDNGKVVITDFGLFGISGVVREGRRENQLKLSHD 637
+ ++H+DLKS N+ ++ + ITDFGL RE + Q+ +
Sbjct: 232 EALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGL------AREWHKTTQMSAAGT 285
Query: 638 WLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIG 697
+ ++APE+++ T FSK +DV++FG + +EL + P + A +
Sbjct: 286 Y-AWMAPEVIKAST---------FSKGSDVWSFGVLLWELLTGEVPYRGIDCLA----VA 331
Query: 698 SGEGMKRVLTSV--SLGKEVSEILSACWAFDLQERPSFSLLMDMLEKL 743
G + ++ + + + +++++ CWA D RP F+ ++ LE L
Sbjct: 332 YGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEAL 379
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 101 bits (251), Expect = 3e-21
Identities = 79/287 (27%), Positives = 131/287 (45%), Gaps = 44/287 (15%)
Query: 458 KASQTSVYLQE---WDIPFEQVELGEPIGQGRWGRVHRGRWHGE-VAIRLLEMDGHNQDH 513
KA T LQ+ W++PFE++ + +G G G V G++ E VAI+ +
Sbjct: 147 KAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNET--- 203
Query: 514 LKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVR-----DPKTSL 568
++ + R+ +H N++ F G C P II +C L+ +R P+ +
Sbjct: 204 ------DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLV 257
Query: 569 DINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVV-ITDFGLFGISGVVREGR 627
D + I GM YLH I+H+DLKS NV + V I+DFG +
Sbjct: 258 DWSTG------IASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFG-------TSKEL 304
Query: 628 RENQLKLSH-DWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKN 686
+ K+S + ++APE++R P S+ D+++FG V +EL + P K+
Sbjct: 305 SDKSTKMSFAGTVAWMAPEVIRNE---------PVSEKVDIWSFGVVLWELLTGEIPYKD 355
Query: 687 QAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSF 733
+ A IW +GS V ++ G ++ ++ W + RPSF
Sbjct: 356 VDSSAIIWGVGSNSLHLPVPSTCPDGFKI--LMKQTWQSKPRNRPSF 400
>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
Length = 1061
Score = 92.8 bits (229), Expect = 1e-18
Identities = 72/250 (28%), Positives = 120/250 (48%), Gaps = 23/250 (9%)
Query: 510 NQDHLKLFKK---EVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKT 566
N+ ++L +K E+ + R ++E++ F+GAC +PP++ I+T +C +L + +
Sbjct: 570 NRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESI 629
Query: 567 SLDINKTRQIAQEIIKGMGYLHAKGIV-HKDLKSKNVFYDNGKVV-ITDFGLFGISGV-V 623
+LD + +I+KGM +LH I H +LKS N D V+ ITD+GL +
Sbjct: 630 TLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDP 689
Query: 624 REGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWP 683
+G KL + APE++R +P + S+A DVY+FG + E+ R
Sbjct: 690 EQGHTVYAKKL------WTAPELLRMASP-----PVRGSQAGDVYSFGIILQEIALRSGV 738
Query: 684 LKNQAAEASIWQI------GSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLM 737
+ + S +I G + L S +E+ ++ CWA D QERP F +
Sbjct: 739 FHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIR 798
Query: 738 DMLEKLPKLN 747
L K + N
Sbjct: 799 LTLRKFNREN 808
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 92.4 bits (228), Expect = 1e-18
Identities = 70/280 (25%), Positives = 126/280 (45%), Gaps = 24/280 (8%)
Query: 469 WDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTR 528
W+ P + LG +G+G +G V G W G + + + + N L KE+ + R
Sbjct: 223 WERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDL-AKEIQTLKGLR 281
Query: 529 HENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPK-TSLDINKTRQIAQEIIKGMGYL 587
HE ++ C + I+T + L +F+ P+ +L + A ++ +GM YL
Sbjct: 282 HERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYL 341
Query: 588 HAKGIVHKDLKSKNVFYDNGKVV-ITDFGLFGISGVVREG--RRENQLKLSHDWLCYLAP 644
+ +VH+DL ++NV D+G + DFGL + ++++ + K+ W AP
Sbjct: 342 EEQRVVHRDLAARNVLVDDGLACKVADFGL---ARLLKDDIYSPSSSSKIPVKW---TAP 395
Query: 645 EIVREMTPGKDEDQLPFSKAADVYAFGTVWYEL-QARDWPLKNQAAEASIWQIGSGEGMK 703
E FS+ +DV++FG + +E+ P + ++ QI G +
Sbjct: 396 EAANYRV---------FSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLP 446
Query: 704 RVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKL 743
R + EV ++ CW +ERPSF+ L + L +
Sbjct: 447 R---PAACPAEVYVLMLECWRSSPEERPSFATLREKLHAI 483
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 92.0 bits (227), Expect = 2e-18
Identities = 64/289 (22%), Positives = 133/289 (46%), Gaps = 18/289 (6%)
Query: 454 PISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDH 513
P + + + +W+ P E+ L +G G +G V G W V + + + N H
Sbjct: 169 PCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLH 228
Query: 514 LKLFKKEVMNYRQTRHENVV-LFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINK 572
++ + E+ ++ RH++++ L+ + P I KG L + L +++
Sbjct: 229 QQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSE 288
Query: 573 TRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQL 632
IA ++ +GM YL ++ +H+DL ++N+ G+ + G FG++ +++E +
Sbjct: 289 LLDIAWQVAEGMCYLESQNYIHRDLAARNILV--GENTLCKVGDFGLARLIKE-----DV 341
Query: 633 KLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQAR-DWPLKNQAAEA 691
LSHD I + T + + +S +DV++FG + +E+ +R P +
Sbjct: 342 YLSHD------HNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHE 395
Query: 692 SIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDML 740
+ ++ +G R+ + V +++ CW D ++RP F L + L
Sbjct: 396 AFLRVDAG---YRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERL 441
>gi|4826776 Janus kinase 2 [Homo sapiens]
Length = 1132
Score = 91.3 bits (225), Expect = 3e-18
Identities = 74/277 (26%), Positives = 132/277 (47%), Gaps = 36/277 (12%)
Query: 480 EPIGQGRWGRVHRGRWH------GEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVV 533
+ +G+G +G V R+ GEV + + ++ ++HL+ F++E+ + +H+N+V
Sbjct: 853 QQLGKGNFGSVEMCRYDPLQDNTGEV-VAVKKLQHSTEEHLRDFEREIEILKSLQHDNIV 911
Query: 534 LFMGACMNPP--HLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKG 591
+ G C + +L +I + +L +++ K +D K Q +I KGM YL K
Sbjct: 912 KYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKR 971
Query: 592 IVHKDLKSKNVFYDN-GKVVITDFGLFGISGVVREGRRENQLK-LSHDWLCYLAPEIVRE 649
+H+DL ++N+ +N +V I DFGL + V+ + + ++K + + APE + E
Sbjct: 972 YIHRDLATRNILVENENRVKIGDFGL---TKVLPQDKEYYKVKEPGESPIFWYAPESLTE 1028
Query: 650 MTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSV 709
FS A+DV++FG V YEL K+ AE +G V +
Sbjct: 1029 S---------KFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLI 1079
Query: 710 SLGK-------------EVSEILSACWAFDLQERPSF 733
L K E+ I++ CW ++ +RPSF
Sbjct: 1080 ELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSF 1116
Score = 47.4 bits (111), Expect = 5e-05
Identities = 56/290 (19%), Positives = 123/290 (42%), Gaps = 44/290 (15%)
Query: 474 EQVELGEPIGQGRWGRVHRG---------RWHGEVAIRLLEMDGHNQDHLKLFKKEVMNY 524
E + E +GQG + ++ +G + H E + L +D ++++ + F +
Sbjct: 543 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLH-ETEVLLKVLDKAHRNYSESFFEAASMM 601
Query: 525 RQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGM 584
+ H+++VL G C+ ++ F K +L ++++ K ++I ++A+++ M
Sbjct: 602 SKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAM 661
Query: 585 GYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQ----LKLSHDW-- 638
+L ++H ++ +KN+ ++RE R+ +KLS
Sbjct: 662 HFLEENTLIHGNVCAKNIL------------------LIREEDRKTGNPPFIKLSDPGIS 703
Query: 639 LCYLAPEIVREMTPGKD----EDQLPFSKAADVYAFGTVWYEL-QARDWPLKNQAAEASI 693
+ L +I++E P E+ + A D ++FGT +E+ D PL ++ +
Sbjct: 704 ITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKL 763
Query: 694 WQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKL 743
R E++ +++ C ++ RPSF ++ L L
Sbjct: 764 QFYED-----RHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSL 808
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 90.5 bits (223), Expect = 5e-18
Identities = 77/297 (25%), Positives = 138/297 (46%), Gaps = 26/297 (8%)
Query: 455 ISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRW----HGEVAIRLLEMDGHN 510
I + + T ++++I E++ELG IG+G++G VH+G + + +A+ +
Sbjct: 423 IDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCT 482
Query: 511 QDHLK-LFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLD 569
D ++ F +E + RQ H ++V +G P + II C L SF++ K SLD
Sbjct: 483 SDSVREKFLQEALTMRQFDHPHIVKLIGVITENP-VWIIMELCTLGELRSFLQVRKYSLD 541
Query: 570 INKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGR-- 627
+ A ++ + YL +K VH+D+ ++NV + V G FG+S + +
Sbjct: 542 LASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCV--KLGDFGLSRYMEDSTYY 599
Query: 628 RENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGT-VWYELQARDWPLKN 686
+ ++ KL W +APE + F+ A+DV+ FG +W L P +
Sbjct: 600 KASKGKLPIKW---MAPESINFRR---------FTSASDVWMFGVCMWEILMHGVKPFQG 647
Query: 687 QAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKL 743
I +I +GE R+ + + +++ CWA+D RP F+ L L +
Sbjct: 648 VKNNDVIGRIENGE---RLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTI 701
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 90.5 bits (223), Expect = 5e-18
Identities = 77/297 (25%), Positives = 138/297 (46%), Gaps = 26/297 (8%)
Query: 455 ISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRW----HGEVAIRLLEMDGHN 510
I + + T ++++I E++ELG IG+G++G VH+G + + +A+ +
Sbjct: 401 IDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCT 460
Query: 511 QDHLK-LFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLD 569
D ++ F +E + RQ H ++V +G P + II C L SF++ K SLD
Sbjct: 461 SDSVREKFLQEALTMRQFDHPHIVKLIGVITENP-VWIIMELCTLGELRSFLQVRKYSLD 519
Query: 570 INKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGR-- 627
+ A ++ + YL +K VH+D+ ++NV + V G FG+S + +
Sbjct: 520 LASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCV--KLGDFGLSRYMEDSTYY 577
Query: 628 RENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGT-VWYELQARDWPLKN 686
+ ++ KL W +APE + F+ A+DV+ FG +W L P +
Sbjct: 578 KASKGKLPIKW---MAPESINFRR---------FTSASDVWMFGVCMWEILMHGVKPFQG 625
Query: 687 QAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKL 743
I +I +GE R+ + + +++ CWA+D RP F+ L L +
Sbjct: 626 VKNNDVIGRIENGE---RLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTI 679
>gi|66932999 testis-specific protein kinase 1 [Homo sapiens]
Length = 626
Score = 89.7 bits (221), Expect = 9e-18
Identities = 75/242 (30%), Positives = 111/242 (45%), Gaps = 32/242 (13%)
Query: 445 PSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLL 504
PSS R R +S A + E IG G + V++ R + +L
Sbjct: 38 PSSYRALRSAVSSLAR------------VDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVL 85
Query: 505 EMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDP 564
+M+ + + EV + RH N++ FMG C++ L +T + G TL + P
Sbjct: 86 KMNKLPSNRGNTLR-EVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSP 144
Query: 565 KTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFY---DNG-KVVITDFGLFGIS 620
+ L +A +I +G+ YLH+KG+ H+DL SKN D G V+ DFGL
Sbjct: 145 EP-LSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKI 203
Query: 621 GVVREGRRENQLKL--SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQ 678
V REG R+ L + S W +APE++R + + ADV+AFG V EL
Sbjct: 204 PVYREGARKEPLAVVGSPYW---MAPEVLRGEL---------YDEKADVFAFGIVLCELI 251
Query: 679 AR 680
AR
Sbjct: 252 AR 253
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 87.8 bits (216), Expect = 3e-17
Identities = 75/293 (25%), Positives = 133/293 (45%), Gaps = 25/293 (8%)
Query: 454 PISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHG--EVAIRLLEMDGHNQ 511
P + Q + EW++P E ++L E +G G++G V G ++G +VA++ L+ +
Sbjct: 223 PCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSP 282
Query: 512 DHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPK-TSLDI 570
D F E +Q +H+ +V P + IIT + + +L F++ P L I
Sbjct: 283 D---AFLAEANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTI 338
Query: 571 NKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFY-DNGKVVITDFGLFGISGVVREGRRE 629
NK +A +I +GM ++ + +H+DL++ N+ D I DFGL + RE
Sbjct: 339 NKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTARE 398
Query: 630 NQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARD-WPLKNQA 688
K W APE + T F+ +DV++FG + E+ P
Sbjct: 399 G-AKFPIKW---TAPEAINYGT---------FTIKSDVWSFGILLTEIVTHGRIPYPGMT 445
Query: 689 AEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLE 741
I + G R++ + +E+ +++ CW ++RP+F L +LE
Sbjct: 446 NPEVIQNLERG---YRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLE 495
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 87.8 bits (216), Expect = 3e-17
Identities = 75/293 (25%), Positives = 133/293 (45%), Gaps = 25/293 (8%)
Query: 454 PISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHG--EVAIRLLEMDGHNQ 511
P + Q + EW++P E ++L E +G G++G V G ++G +VA++ L+ +
Sbjct: 223 PCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSP 282
Query: 512 DHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPK-TSLDI 570
D F E +Q +H+ +V P + IIT + + +L F++ P L I
Sbjct: 283 D---AFLAEANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTI 338
Query: 571 NKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFY-DNGKVVITDFGLFGISGVVREGRRE 629
NK +A +I +GM ++ + +H+DL++ N+ D I DFGL + RE
Sbjct: 339 NKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTARE 398
Query: 630 NQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARD-WPLKNQA 688
K W APE + T F+ +DV++FG + E+ P
Sbjct: 399 G-AKFPIKW---TAPEAINYGT---------FTIKSDVWSFGILLTEIVTHGRIPYPGMT 445
Query: 689 AEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLE 741
I + G R++ + +E+ +++ CW ++RP+F L +LE
Sbjct: 446 NPEVIQNLERG---YRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLE 495
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 87.8 bits (216), Expect = 3e-17
Identities = 72/291 (24%), Positives = 136/291 (46%), Gaps = 28/291 (9%)
Query: 467 QEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKL-FKKEVMNYR 525
++W + E V LGE +G+G +G V++G + ++ + LK+ F +E +
Sbjct: 554 KKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILK 613
Query: 526 QTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMG 585
Q H N+V +G C + II G +F+R K L + + + + + GM
Sbjct: 614 QYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGML 673
Query: 586 YLHAKGIVHKDLKSKNVFY-DNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAP 644
YL +K +H+DL ++N +N + I+DFG+ +G + L + + AP
Sbjct: 674 YLESKNCIHRDLAARNCLVGENNVLKISDFGM----SRQEDGGVYSSSGLKQIPIKWTAP 729
Query: 645 EIVREMTPGKDEDQLPFSKAADVYAFGTVWYE---LQARDWP-LKNQAAEASIWQIGSGE 700
E + G+ +S +DV++FG + +E L +P + NQ A + E
Sbjct: 730 E---ALNYGR------YSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQV------E 774
Query: 701 GMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLS 751
R+ +++S+I+ CW + + RP FS ++ ++L + R+L+
Sbjct: 775 RGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFS---ELQKELTIIKRKLT 822
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 87.4 bits (215), Expect = 4e-17
Identities = 63/273 (23%), Positives = 127/273 (46%), Gaps = 23/273 (8%)
Query: 469 WDIPFEQVELGEPIGQGRWGRVHRGRWHGE--VAIRLLEMDGHNQDHLKLFKKEVMNYRQ 526
W+I + + + +G G++G V G+W G+ VAI++++ ++D K +MN
Sbjct: 395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLS- 453
Query: 527 TRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGY 586
HE +V G C + IIT + L +++R+ + + ++ +++ + M Y
Sbjct: 454 --HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEY 511
Query: 587 LHAKGIVHKDLKSKN-VFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPE 645
L +K +H+DL ++N + D G V ++DFGL ++ L ++ + +
Sbjct: 512 LESKQFLHRDLAARNCLVNDQGVVKVSDFGL-------------SRYVLDDEYTSSVGSK 558
Query: 646 IVREMTPGKDEDQLPFSKAADVYAFGTVWYELQA-RDWPLKNQAAEASIWQIGSGEGMKR 704
+P + FS +D++AFG + +E+ + P + + I G R
Sbjct: 559 FPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQG---LR 615
Query: 705 VLTSVSLGKEVSEILSACWAFDLQERPSFSLLM 737
+ ++V I+ +CW ERP+F +L+
Sbjct: 616 LYRPHLASEKVYTIMYSCWHEKADERPTFKILL 648
>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 87.4 bits (215), Expect = 4e-17
Identities = 70/302 (23%), Positives = 140/302 (46%), Gaps = 31/302 (10%)
Query: 452 RGPISRKASQT--SVYLQE--WDIPFEQVELGEPIGQGRWGRVHRGRWHGE--VAIRLLE 505
R P+S KA++ SV L W++ E++ L + +G G++G V G+W G+ VA+++++
Sbjct: 389 RHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIK 448
Query: 506 MDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPK 565
++D F +E + H +V F G C + I+T + L +++R
Sbjct: 449 EGSMSEDE---FFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHG 505
Query: 566 TSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVV-ITDFGLFGISGVVR 624
L+ ++ ++ ++ +GM +L + +H+DL ++N D V ++DFG+ + V
Sbjct: 506 KGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGM---TRYVL 562
Query: 625 EGRRENQL--KLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFG-TVWYELQARD 681
+ + + + K W APE+ +S +DV+AFG +W
Sbjct: 563 DDQYVSSVGTKFPVKW---SAPEVFH---------YFKYSSKSDVWAFGILMWEVFSLGK 610
Query: 682 WPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLE 741
P + ++ G + R + + +I+ +CW ++RP+F L+ +E
Sbjct: 611 QPYDLYDNSQVVLKVSQGHRLYRPHLA---SDTIYQIMYSCWHELPEKRPTFQQLLSSIE 667
Query: 742 KL 743
L
Sbjct: 668 PL 669
>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 87.4 bits (215), Expect = 4e-17
Identities = 70/302 (23%), Positives = 140/302 (46%), Gaps = 31/302 (10%)
Query: 452 RGPISRKASQT--SVYLQE--WDIPFEQVELGEPIGQGRWGRVHRGRWHGE--VAIRLLE 505
R P+S KA++ SV L W++ E++ L + +G G++G V G+W G+ VA+++++
Sbjct: 389 RHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIK 448
Query: 506 MDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPK 565
++D F +E + H +V F G C + I+T + L +++R
Sbjct: 449 EGSMSEDE---FFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHG 505
Query: 566 TSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVV-ITDFGLFGISGVVR 624
L+ ++ ++ ++ +GM +L + +H+DL ++N D V ++DFG+ + V
Sbjct: 506 KGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGM---TRYVL 562
Query: 625 EGRRENQL--KLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFG-TVWYELQARD 681
+ + + + K W APE+ +S +DV+AFG +W
Sbjct: 563 DDQYVSSVGTKFPVKW---SAPEVFH---------YFKYSSKSDVWAFGILMWEVFSLGK 610
Query: 682 WPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLE 741
P + ++ G + R + + +I+ +CW ++RP+F L+ +E
Sbjct: 611 QPYDLYDNSQVVLKVSQGHRLYRPHLA---SDTIYQIMYSCWHELPEKRPTFQQLLSSIE 667
Query: 742 KL 743
L
Sbjct: 668 PL 669
>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
Length = 694
Score = 86.7 bits (213), Expect = 8e-17
Identities = 84/327 (25%), Positives = 147/327 (44%), Gaps = 50/327 (15%)
Query: 441 VDDLPSSRRPWRGPISRKAS---QTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHG 497
+D L S+++P +++K+ +V +W + E + LGE IG+G +G V GR
Sbjct: 399 IDHLLSTQQP----LTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRA 454
Query: 498 E---VAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKG 554
+ VA++ + D F +E +Q H N+V +G C + I+ +G
Sbjct: 455 DNTLVAVKSCR-ETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQG 513
Query: 555 RTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVV-ITD 613
+F+R L + Q+ + GM YL +K +H+DL ++N V+ I+D
Sbjct: 514 GDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISD 573
Query: 614 FGL--------FGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAA 665
FG+ + SG G R+ +K + APE + G+ +S +
Sbjct: 574 FGMSREEADGVYAASG----GLRQVPVK-------WTAPE---ALNYGR------YSSES 613
Query: 666 DVYAFGTVWYE---LQARDWP-LKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSA 721
DV++FG + +E L A +P L NQ + + G R+ V ++
Sbjct: 614 DVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG------RLPCPELCPDAVFRLMEQ 667
Query: 722 CWAFDLQERPSFSLLMDMLEKLPKLNR 748
CWA++ +RPSFS + L+ + K +R
Sbjct: 668 CWAYEPGQRPSFSTIYQELQSIRKRHR 694
>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
Length = 752
Score = 86.7 bits (213), Expect = 8e-17
Identities = 84/327 (25%), Positives = 147/327 (44%), Gaps = 50/327 (15%)
Query: 441 VDDLPSSRRPWRGPISRKAS---QTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHG 497
+D L S+++P +++K+ +V +W + E + LGE IG+G +G V GR
Sbjct: 457 IDHLLSTQQP----LTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRA 512
Query: 498 E---VAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKG 554
+ VA++ + D F +E +Q H N+V +G C + I+ +G
Sbjct: 513 DNTLVAVKSCR-ETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQG 571
Query: 555 RTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVV-ITD 613
+F+R L + Q+ + GM YL +K +H+DL ++N V+ I+D
Sbjct: 572 GDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISD 631
Query: 614 FGL--------FGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAA 665
FG+ + SG G R+ +K + APE + G+ +S +
Sbjct: 632 FGMSREEADGVYAASG----GLRQVPVK-------WTAPE---ALNYGR------YSSES 671
Query: 666 DVYAFGTVWYE---LQARDWP-LKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSA 721
DV++FG + +E L A +P L NQ + + G R+ V ++
Sbjct: 672 DVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG------RLPCPELCPDAVFRLMEQ 725
Query: 722 CWAFDLQERPSFSLLMDMLEKLPKLNR 748
CWA++ +RPSFS + L+ + K +R
Sbjct: 726 CWAYEPGQRPSFSTIYQELQSIRKRHR 752
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,616,047
Number of Sequences: 37866
Number of extensions: 1871428
Number of successful extensions: 20681
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 604
Number of HSP's successfully gapped in prelim test: 608
Number of HSP's that attempted gapping in prelim test: 15406
Number of HSP's gapped (non-prelim): 4689
length of query: 762
length of database: 18,247,518
effective HSP length: 110
effective length of query: 652
effective length of database: 14,082,258
effective search space: 9181632216
effective search space used: 9181632216
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.